title: Controlled self-assembly of carbohydrate conjugate rod-coil amphiphiles for supramolecular multivalent ligands.
abstract: Carbohydrate conjugate rod-coil amphiphiles were synthesized and their self-assembling behavior in aqueous solution was investigated. These amphiphiles were observed to self-assemble into supramolecular structures that differ significantly depending on the molecular architecture. The rod-coil amphiphiles based on a short coil (1) self-assemble into a vesicular structure, while the amphiphiles with a long coil (2) show a spherical micellar structure. In contrast, 3, based on a twin-rod segment, was observed to aggregate into cylindrical micelles with twice the diameter of molecular length scale. As a means to determine the binding activity to protein receptors of these supramolecular objects, hemagglutination inhibition assay was performed. The experiments showed that the supramolecular architecture has a significant effect on the binding activity. In addition, incubation experiments with Escherichia coli showed that mannose-coated objects specifically bind to the bacterial pili of the ORN 178 strain. These results demonstrate that precise control of the nano-objects in shape and size by molecular design can provide control of the biological activities of the supramolecular materials.
authors.affiliation: Center for Supramolecular Nano-Assembly and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Kim
authors.forename: Dong-Je
authors.initials: DJ
authors.lastname: Hong
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Bae
authors.forename: Myongsoo
authors.initials: M
authors.lastname: Lee
mesh_terms: D000818:Animals; D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology; D002449:Cell Aggregation; D003208:Concanavalin A / Q000494:pharmacology; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D008024:Ligands; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D011817:Rabbits
chemical_list: D002241:Carbohydrates; D008024:Ligands; D008823:Micelles; D003208:Concanavalin A