Pitfalls in estimating piperaquine elimination.
By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.
Tarning
Joel
J
Department of Pharmacology, Göteborg University, Sweden.
Lindegårdh
Niklas
N
Annerberg
Anna
A
Singtoroj
Thida
T
Day
Nicholas P J
NP
Ashton
Michael
M
White
Nicholas J
NJ
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D011804:Quinolines / Q000737:chemistry / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D010879:Piperazines
D000962:Antimalarials; D011804:Quinolines; C034759:piperaquine; D010879:Piperazines