A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children.
An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.
Jenkins
Neil E
NE
Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya. njenkins@liverpool.ac.uk
Mwangi
Tabitha W
TW
Kortok
Moses
M
Marsh
Kevin
K
Craig
Alister G
AG
Williams
Thomas N
TN
D005334:Fever / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007223:Infant; D007239:Infections / Q000453:epidemiology / Q000235:genetics*; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D007630:Kenya / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology / Q000235:genetics; D011110:Polymorphism, Genetic
D018799:Intercellular Adhesion Molecule-1