Fungal arthritis and osteomyelitis.
Fungal arthritis and osteomyelitis are uncommon diseases and generally present in an indolent fashion. The incidence of fungal bone and joint dis-ease is increasing with an increase in the prevalence of factors predisposing to invasive fungal disease, such as the use of central venous catheters, broad spectrum antibiotics, immunosuppression, and abdominal surgery. Definitive diagnosis relies on bone or synovial culture or biopsy. Successful management has traditionally consisted of amphotericin B in combination with surgical debridement. Given the rarity of this disease, treatment is not well defined, but reports of success with the use of azole antifungal agents, including itraconazole, fluconazole, voriconazole, and posaconazole, are promising.
Kohli
Rakhi
R
Tufts University School of Medicine, Division of Geographic Medicine and Infectious Disease, Tufts-New England Medical Center, Boston, MA 02111, USA.
Hadley
Susan
S
D017088:AIDS-Related Opportunistic Infections; D001170:Arthritis, Infectious / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009181:Mycoses / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D010019:Osteomyelitis / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D016459:Prosthesis-Related Infections / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D015819:Substance Abuse, Intravenous