title: Correlation between hyperglycemia and mortality in a medical and surgical intensive care unit.
abstract: OBJECTIVE
  The aim of this study was to assess the correlation between hyperglycemia and mortality in a group of patients admitted to a medical and surgical ICU and to evaluate if the association between hyperglycemia and reason of ICU admission significantly worsens patients' outcomes.
  
  
  METHODS
  A retrospective clinical study was conducted in the ICU of a University Hospital. Four-hundred and twelve adult patients admitted to our ICU were enrolled. The blood glucose level was measured at the time of admission and daily at 2-4 h intervals. When the glucose level exceeded 180 mg/dL, an insulin bolus or a continuous infusion were performed to maintain the glucose level at or below 180-200 mg/dL.
  
  
  RESULTS
  Analysing the mean blood glucose levels of patients with the receiver operating characteristic (ROC) curve, it resulted that the blood glucose level of 141.7 mg/dL had higher sensitivity (76%) and specificity (56.5%) to discriminate the probability of death. In other words, in patients in whom the mean blood glucose levels were greater than 141.7 mg/dL, the probability of death was higher (26.62%) than in the group of patients in whom a strict blood glucose control was maintained (13.55%) (P = 0.0017).
  
  
  CONCLUSIONS
  A strict blood glucose control seems to be crucial, even in a medical and surgical ICU. The need for intensive insulin therapy, even by means of continuous infusion of insulin, to obtain the normalization of blood glucose levels, appears essential.
authors.affiliation: Department of Medical and Surgical Emergencies, Polytechnic University of Marche, Ancona, Italy. Vincenzo_Gabbanelli@tin.it
authors.forename: V
authors.initials: V
authors.lastname: Gabbanelli
authors.forename: S
authors.initials: S
authors.lastname: Pantanetti
authors.forename: A
authors.initials: A
authors.lastname: Donati
authors.forename: T
authors.initials: T
authors.lastname: Principi
authors.forename: P
authors.initials: P
authors.lastname: Pelaia
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000401:mortality*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose