title: Spying on IgE receptor signaling: simply complex, or not?
abstract: Plasma membrane organization and the potential role, or not, of lipid raft microdomains in signal transduction is a controversial topic. Cross-correlation fluorescent correlation spectroscopy (CC-FCS) shows promise as a new approach to rapidly probe protein-protein interactions in living cells during signal transduction. CC-FCS data from studies of IgE receptor signaling challenge models of large stable lipid raft signaling domains and reveal a new complexity in the dynamic (re)organization of signaling complexes.
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA. derek.toomre@yale.edu
authors.forename: Derek
authors.initials: D
authors.lastname: Toomre
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D004058:Diffusion; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D010766:Phosphorylation; D017455:Receptors, IgE / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013050:Spectrometry, Fluorescence; D019061:src-Family Kinases / Q000502:physiology*
chemical_list: D017455:Receptors, IgE; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases