title: Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on methicillin-resistant Staphylococcus aureus (MRSA) infection in mice.
abstract: Anti-bacterial activity of two synthesized oligopeptides, RLYLRIGRR-NH2 (peptide A) and RLRLRIGRR-NH2 (peptide B), both which based on a putative active site of defensin, an anti-bacterial peptide from the beetle Allomyrina dichotoma, was examined by macroscopic and histopathologic assessment during the course of infection in mice inoculated with methicillin-resistant Staphylococcus aureus (MRSA) in vivo. Both peptides A and B decreased the mortality of mice inoculated with MRSA. Peptides A and B decreased the macroscopical and histopathological lesions by MRSA infection in mice even seven days after the challenge. The anti-bacterial activity of peptides A and B has a therapeutic effect on MRSA infection in mice even seven days after being challenged.
authors.affiliation: National Institute of Animal Health, Tsukuba, Ibaraki, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamada
authors.forename: Kikuyasu
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hisako
authors.initials: H
authors.lastname: Saido-Sakanaka
authors.forename: Ai
authors.initials: A
authors.lastname: Asaoka
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakawa
authors.forename: Yu
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yukari
authors.initials: Y
authors.lastname: Koyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Hikosaka
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hirota
mesh_terms: D000818:Animals; D001517:Coleoptera / Q000737:chemistry*; D004285:Dogs / Q000382:microbiology; D007668:Kidney / Q000473:pathology; D008297:Male; D016106:Methicillin Resistance / Q000502:physiology; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use*; D010413:Penis / Q000473:pathology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology
chemical_list: D009842:Oligopeptides