Synthesis and characterization of a series of carbamate-linked cationic lipids for gene delivery.
A series of pH-sensitive lipids, la-h [(2,3-bis-alkylcarbamoyloxy-propyl)-trialkylammonium halide] and 2a-d (1-di-methylamino-2,3-bis-alkylcarbamoyloxy-propane), with carbamate linkages between the hydrocarbon chains and an ammonium or tertiary amine head, were synthesized for liposome-mediated gene delivery. The variable length of the carbon chains and the quaternary ammonium or neutral tertiary amine heads allowed us to identify the structure-function relationship showing how these factors would affect cationic lipids in gene delivery performance.
Liu
Dongliang
D
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China. dut-liu@163.com
Hu
Jianjun
J
Qiao
Weihong
W
Li
Zongshi
Z
Zhan
Shubiao
S
Cheng
Lvbo
L
D002219:Carbamates / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D014162:Transfection / Q000379:methods*
D002219:Carbamates; D008055:Lipids