Increased risk of cancer among relatives of patients with lung cancer in China.
BACKGROUND
Genetic factors were considered as one of the risk factors for lung cancer or other cancers. The aim of this work was to determine whether a genetic predisposition accounts for such familial aggregation of cancer among relatives of lung cancer probands.


METHODS
A case-control study was conducted in 800 case families identified by lung cancer patients (probands), and in 800 control families identified by the probands'spouses. The data were analysed with logistic regression analysis model.


RESULTS
The data revealed a significantly greater overall risk of cancer (OR = 1.82, P < 0.01) in the proband group. The relatives of lung cancer probands maintained an increased risk of non-lung cancer (P < 0.05) after adjusting for confounder factors. The crude odds ratio of a proband family having one family member with cancer was 1.67 compared with control families. Proband families were 2.56 times more likely to have two other family members with cancer. For three cancers and four or more cancers, the risk increased to 3.50 and 5.91, respectively. The most striking differences in cancer prevalence between proband and control families were noted for cancer risk among female relatives. The strongest effects were for not only lung cancer in any female relatives (OR 2.17, 95%CI 1.60-3.64) and mothers (OR 2.78, 95%CI 1.23-5.12) and sisters (OR 2.03, 95%CI 1.26-3.97), but also non-lung cancer in females and mothers (OR 2.00, 95%CI 1.26-3.01, and OR 2.34, 95%CI 1.28-4.40, respectively).


CONCLUSIONS
These data support the hypothesis of a genetic susceptibility to cancer in families with lung cancer, and the female genetic susceptibility to cancer might be greater than male.
Jin
Yongtang
Y
School of Public Health, Anhui Medical University, Hefei 230032, PR China. jinedu@163.com
Xu
Yingchun
Y
Xu
Ming
M
Xue
Saoli
S
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D015995:Prevalence; D012044:Regression Analysis; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors