title: Mast cells, TGF-beta1 and myofibroblasts expression in lupus nephritis outcome.
abstract: Renal biopsies of 69 patients with lupus nephritis were studied according to the WHO classification. The aim of the present study was to correlate the interstitial tryptase-positive mast cells with the interstitial TGF-beta1 and alpha-SM actin expression and clinical outcome of lupus nephritis, and identify the pathological role of the interstitial tryptase-positive mast cells in lupus nephritis. The mean follow-up time was 70.7 +/- 54.4 months. Eight patients were grouped as WHO class II lupus nephritis, 15 patients as class III, 28 patients as class IV and 18 patients as class V. Interstitial tryptase-positive mast cells were not correlated with clinical outcome and interstitial TGF-beta1 expression in lupus nephritis. Interstitial tryptase-positive mast cells were correlated with tubulo-interstitial alpha-SM actin expression for WHO class V lupus nephritis, but not to the other classes. In conclusion, in spite of interstitial tryptase-positive mast cells being related to renal interstitial fibrosis process, their expression according to the clinical outcome of lupus nephritis was not significant.
authors.affiliation: Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
authors.forename: R Cuan
authors.initials: RC
authors.lastname: Ravinal
authors.forename: R S
authors.initials: RS
authors.lastname: Costa
authors.forename: T M
authors.initials: TM
authors.lastname: Coimbra
authors.forename: M
authors.initials: M
authors.lastname: Dantas
authors.forename: M A
authors.initials: MA
authors.lastname: dos Reis
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D015415:Biomarkers; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D007668:Kidney; D008181:Lupus Nephritis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1; D053802:Tryptases
chemical_list: D000199:Actins; D015415:Biomarkers; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D012697:Serine Endopeptidases; D053802:Tryptases