title: Distribution of (3)H-dopamine and (3)H-DAGO binding sites in the central part of rat sinoatrial node.
abstract: Distribution of (3)H-dopamine and (3)H-DAGO binding sites was studied by autoradiography on semithin sections of total preparations of rat sinoatrial node. The relative density of (3)H-dopamine and (3)H-DAGO binding sites in the functional nucleus of the sinoatrial node was minimum and increased in the cranial and caudal directions. The level of (3)H-dopamine binding in the perinodal atrial myocardium was appreciably lower (22+/-6%), while binding of (3)H-DAGO was similar (76+/-16%) to that in the periarterial zone of the sinoatrial node.
authors.affiliation: Department of Morphology, Russian State Medical University, Moscow.
authors.forename: P V
authors.initials: PV
authors.lastname: Sutyagin
authors.forename: E E
authors.initials: EE
authors.lastname: Kalinina
authors.forename: A S
authors.initials: AS
authors.lastname: Pylaev
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001345:Autoradiography; D001665:Binding Sites; D004298:Dopamine / Q000096:biosynthesis*; D004566:Electrodes; D004594:Electrophysiology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000737:chemistry*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012849:Sinoatrial Node / Q000378:metabolism*
chemical_list: D000889:Anti-Arrhythmia Agents; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004298:Dopamine