[An unusual case of pyoderma gangrenosum with necrotizing granulomatous dermatitis].
Four distinctive clinical and histological variants of pyoderma gangrenosum have been proposed: (1) ulcerative, (2) pustular, (3) bullous, and (4) vegetative. The rate of progression and associated systemic diseases, as well as the histopathologic changes, can vary considerably between these clinical variants. A 64-year-old man presented with ulcerative pyoderma gangrenosum associated with renal cell carcinoma and IgA paraproteinemia; he responded to oral thalidomide. Histopathology revealed unusual findings with signs of leukocytoclastic vasculitis, basophilic degeneration of collagen and zones of suppuration with a palisaded histiocytic and epithelioid granulomatous infiltration throughout the dermis.
Meier
Friedegund
F
Abteilung für Dermatologie, Universität Tübingen, Tübingen, Deutschland. friedegund.meier@med.uni-tuebingen.de
Berner
Diana
D
Scherwitz
Christian
C
Rassner
Gernot
G
Metzler
Gisela
G
D003872:Dermatitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D006099:Granuloma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D035583:Rare Diseases / Q000175:diagnosis / Q000188:drug therapy; D013792:Thalidomide / Q000627:therapeutic use*; D016896:Treatment Outcome
D013792:Thalidomide