title: Assessment of adherence to highly active antiretroviral therapy in a cohort of African HIV-infected children in Abidjan, Côte d'Ivoire.
abstract: African HIV-infected children benefit from access to antiretroviral treatments but little is known about their adherence. A cross-sectional assessment of adherence to highly active antiretroviral therapy was conducted among a group of children recruited in an observational cohort in Abidjan, Côte d'Ivoire. Adherence was determined by a 1-month recall by child or caregiver, with full adherence signifying no interruptions in the prior month. One-third reported less than full adherence. Undetectable viral load was associated with full adherence in a subset of children with a P value <10% (P = 0.098). As compared with children with full adherence, those with less than full adherence were significantly older and more likely to be taking efavirenz. These findings underscore the necessity of assessing and supporting children's adherence routinely in AIDS care institutions.
authors.affiliation: Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux, France. arrive_elise@yahoo.fr
authors.forename: Arrivé
authors.initials: A
authors.lastname: Elise
authors.forename: Anaky Marie
authors.initials: AM
authors.lastname: France
authors.forename: Wemin Marie
authors.initials: WM
authors.lastname: Louise
authors.forename: Diabate
authors.initials: D
authors.lastname: Bata
authors.forename: Rouet
authors.initials: R
authors.lastname: François
authors.forename: Salamon
authors.initials: S
authors.lastname: Roger
authors.forename: Msellati
authors.initials: M
authors.lastname: Philippe
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000480:Alkynes; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D048588:Benzoxazines; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D007560:Cote d'Ivoire; D003430:Cross-Sectional Studies; D003521:Cyclopropanes; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010078:Oxazines / Q000627:therapeutic use; D010349:Patient Compliance; D016312:Treatment Refusal; D019562:Viral Load
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; C098320:efavirenz