title: GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information.
abstract: Four related experiments studied operant performance of mice on differential reinforcement of low rates of responding (DRL) paradigms. Experiment 1 showed that excitotoxic hippocampal lesions impaired performance of a 10-s DRL schedule (DRL-10). Experiments 2 and 3 showed that GluR-A AMPA receptor subunit knockout mice, which are deficient in CA3-CA1 long-term potentiation (LTP), were markedly impaired at 15 s (DRL-15), but less impaired at DRL-10. Experiment 4 compared DRL-15 performance in mice from the 2 strains from which the GluR-A colony was derived and showed that they did not differ. The results show that GluR-A-containing AMPA receptors are required for normal performance on hippocampus-dependent, nonspatial working memory tasks, consistent with a role for GluR-A in the temporal encoding (what happened when) of nonspatial information.
authors.affiliation: Department of Experimental Psychology, University of Oxford, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Reisel
authors.forename: D M
authors.initials: DM
authors.lastname: Bannerman
authors.forename: R M J
authors.initials: RM
authors.lastname: Deacon
authors.forename: R
authors.initials: R
authors.lastname: Sprengel
authors.forename: P H
authors.initials: PH
authors.lastname: Seeburg
authors.forename: J N P
authors.initials: JN
authors.lastname: Rawlins
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000502:physiology*; D018091:Receptors, AMPA / Q000172:deficiency / Q000502:physiology*; D012055:Reinforcement Schedule; D012201:Reward; D013569:Synapses / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA