A rat model of preeclampsia.
Preeclampsia/eclampsia is a disorder of human pregnancy that continues to exact significant maternal morbidity and mortality and fetal wastage. Therapy of these disorders has not changed in over 50 years and there are no proven preventive measures. We describe a model of the development of a syndrome in the pregnant rat that resembles preeclampsia, which results from the imposition of excessive volume expansion early in gestation. We administered desoxycorticosterone acetate (DOCA) to pregnant animals whose drinking water had been replaced with saline. We compared the results obtained in these animals with those resulting from the study of control, virgin animals, virgin animals receiving DOCA and saline, and normal pregnant (NP) animals. The virgin animals given DOCA and saline did not become hypertensive. The experimental paradigm in the DOCA plus saline pregnant (PDS) animals provides many of the phenotypic characteristics of the human disorder including the development of hypertension, proteinuria, and intrauterine growth restriction. In addition, the mean blood nitrite/nitrate concentration was reduced in the PDS rats compared with their NP counterparts. We propose that this model may prove to be useful in the study of the human condition.
Ianosi-Irimie
Monica
M
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Vu
Hop V
HV
Whitbred
Joy M
JM
Pridjian
Candice A
CA
Nadig
J D
JD
Williams
Marian Y
MY
Wrenn
Dené C
DC
Pridjian
Gabriella
G
Puschett
Jules B
JB
D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D003900:Desoxycorticosterone / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced / Q000503:physiopathology; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology; D007668:Kidney / Q000473:pathology; D011225:Pre-Eclampsia / Q000139:chemically induced / Q000503:physiopathology*; D011247:Pregnancy; D011507:Proteinuria / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects
D003900:Desoxycorticosterone; D012965:Sodium Chloride