title: [A case of drug-induced pneumonia possibly associated with simvastatin].
abstract: A 59-year-old woman was admitted because of general fatigue, cough and progressive dyspnea about 5 months after treatment with simvastatin for hyperlipidemia. A chest radiograph and computed tomography scans revealed ground glass and reticular opacities in the right middle and lower lung fields. The percentage of peripheral blood eosinophils was elevated. After simvastatin was discontinued and administration of prednisolone was started, eosinophilia and reticular shadows improved. Drug lymphocyte stimulation test (DLST) for simvastatin was positive, so we diagnosed drug induced eosinophilic pneumonia. Now hyperlipidemia is treated frequently with HMG-CoA reductase inhibitor, but there are few reports demonstrating lung injury by this drug. We should be aware of lung side effects of HMG-CoA reductase inhibitor.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: Sumako
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Seiko
authors.initials: S
authors.lastname: Nakayama
authors.forename: Keiko
authors.initials: K
authors.lastname: Hisatomi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kakugawa
authors.forename: Kanako
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Mioko
authors.initials: M
authors.lastname: Ide
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D006949:Hyperlipidemias / Q000188:drug therapy; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008875:Middle Aged; D013902:Radiography, Thoracic; D019821:Simvastatin / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin