title: Synthesis and anti-HCMV activity of novel 5'-norcarboacyclic nucleosides.
abstract: A very simple route for synthesizing a novel carboacyclic version of 5 cent-noraristeromycin is described. Condensation of the mesylates 9 and 23 with the natural nucleosidic bases (A, U, T, C) under standard nucleophilic substitution (K(2)CO(3), 18-Crown-6, DMF) and deblocking conditions, afforded the target nucleosides 14, 15, 16, 17, 28, 29, 30, and 31. In addition, these compounds were evaluated for their antiviral properties against various viruses.
authors.affiliation: College of Pharmacy, Chosun University, Kwangju, Republic of Korea.
authors.forename: Aihong
authors.initials: A
authors.lastname: Kim
authors.forename: Joon Hee
authors.initials: JH
authors.lastname: Hong
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects*; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides