Virus-host interactions: new insights from the small RNA world.
RNA silencing has a known role in the antiviral responses of plants and insects. Recent evidence, including the finding that the Tat protein of human immunodeficiency virus (HIV) can suppress the host's RNA-silencing pathway and may thus counteract host antiviral RNAs, suggests that RNA-silencing pathways could also have key roles in mammalian virus-host interactions.
Browne
Edward P
EP
Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA. browne@saturn.med.nyu.edu
Li
Junjie
J
Chong
Mark
M
Littman
Dan R
DR
D000818:Animals; D015696:Gene Products, tat / Q000378:metabolism*; D006678:HIV / Q000378:metabolism / Q000472:pathogenicity; D015658:HIV Infections / Q000235:genetics / Q000821:virology; D035683:MicroRNAs / Q000378:metabolism; D008957:Models, Genetic; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism*; D014777:Virus Diseases / Q000235:genetics / Q000821:virology*; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D035683:MicroRNAs; D034741:RNA, Small Interfering; D012367:RNA, Viral; D054322:tat Gene Products, Human Immunodeficiency Virus