Bioactive constituents from roots of Bursera tonkinensis.
Bioassay directed-fractionation led to isolation of 12 compounds from the roots of Bursera tonkinensis Guillaum (Burseraceae), including burselignan, bursephenylpropane, and burseneolignan. Of the 12 compounds, only 4'-demethyldesoxypodophyllotoxin exhibited significant cytotoxic activities against KB, Col2 and LNCaP cell lines.
Jutiviboonsuk
Aranya
A
Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, 447 Si Ayutthaya Road, Ratchathewi District, Bangkok 10400, Thailand.
Zhang
Hongjie
H
Tan
Ghee Teng
GT
Ma
Cuiying
C
Van Hung
Nguyen
N
Manh Cuong
Nguyen
N
Bunyapraphatsara
Nuntavan
N
Soejarto
D Doel
DD
Fong
Harry H S
HH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D031233:Bursera / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C508085:4'-demethyldesoxypodophyllotoxin; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D011034:Podophyllotoxin