C-erbB2 oncoprotein: prognostic marker in breast cancer.
OBJECTIVE
The invasive mammary cancer is the most frequent malign tumor of a woman. Among the potential prognostic factors are included the biomarkers which measure or are associated with biological processes involved in the tumoral progression. We study the prognostic importance of the c-erbB2 oncoprotein in the invasive mammary cancer.


METHODS
We included in the study 56 female patients suffering of invasive mammary cancer. The tissue fragments were fitted in formol, included to paraffin, commonly colored haematoxylin-eosine (HE); for the determination of the c-erbB2 we used the immunohistochemical method of avidin-biotin (ABC) complex.


RESULTS
From the total of 56 tumors, 38 (67.9%) presented different degrees of positivity; 18 (32.1%) did not express the oncoprotein c-erbB2.


CONCLUSIONS
The positivity of c-erbB2 oncoprotein was correlated with the size of the tumor; the carcinomas which are not infiltrative ductal, knows as having a better prognostic, were c-erbB2 negative.
Roşian
Anca
A
Department of Pathology, University of Medicine and Pharmacy "Victor Babeş", Timişoara.
Lazăr
Elena
E
Dema
Alice
A
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology; D044584:Carcinoma, Ductal / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases