Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy.
OBJECTIVE
To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans.


METHODS
This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects.


RESULTS
Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects.


CONCLUSIONS
These rates provide a benchmark that can be used to monitor future treatment response in PSP.
Josephs
Keith A
KA
Department of Neurology, Mayo Clinic, 200 First Street NW, Rochester, MN 55905, USA. josephs.keith@mayo.edu
Whitwell
Jennifer L
JL
Boeve
Bradley F
BF
Shiung
Maria M
MM
Gunter
Jeffrey L
JL
Parisi
Joseph E
JE
Dickson
Dennis W
DW
Jack
Clifford R
CR
D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000473:pathology*; D001344:Autopsy; D002540:Cerebral Cortex / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*