High throughput screening in agrochemical research.
The demand for new herbicides, insecticides and fungicides led to a steady increase in the number of compounds being tested to find novel market products. To keep pace with the rising workload, high throughput screening (HTS) technologies have been introduced. In agrochemical research miniaturised in vivo tests on whole real target organisms are now possible and are an integral part of the screening cascade. A complementary target based in vitro HTS has also been established in agrochemical research. Target based HTS allows a directed approach towards untouched market shares by novel modes of action. Selection of the best suited targets is the most crucial issue in this approach. Genomic methods thereby deliver many essential genes as candidate targets. Consideration of further criteria such as druggability notably narrows down the number of promising targets. Though target to hit to lead progression still is as in pharmaceutical research a complex and therefore risky process, the implementation of novel bioscience technologies has entailed the transition to an integrated innovative agrochemical research perspective.
Tietjen
Klaus
K
Bayer CropScience AG, Research, Biology Fungicides, Building 6240, 40789 Monheim, Germany. Klaus.Tietjen@bayercropscience.com
Drewes
Mark
M
Stenzel
Klaus
K
D016573:Agrochemicals / Q000737:chemistry* / Q000493:pharmacokinetics; D002622:Chemistry, Agricultural / Q000379:methods; D020650:Combinatorial Chemistry Techniques; D018745:Genome, Plant / Q000187:drug effects; D013329:Structure-Activity Relationship
D016573:Agrochemicals