Pseudocyst treatment in chronic pancreatitis--surgical treatment of the underlying disease increases the long-term success.
BACKGROUND
For reasons of persisting controversies concerning indications for surgery, we evaluated chronic pancreatitis patients following pancreatic head resection or drainage procedure for pseudocysts located in the pancreatic head.


METHODS
206 patients (166 male, 40 female) with chronic pancreatitis and pseudocysts in the pancreatic head were operated between April 1982 and July 2001. 169 patients (82%) were treated with the duodenum-preserving pancreatic head resection, a pseudocyst-jejunostomy was performed in 37 patients (18%).


RESULTS
The hospital mortality was 0.4%. The late mortality was 19% in a median follow-up of 7.3 years. The rate of patients with complete relief of pain was significantly higher after resection compared to drainage procedure in the long-term follow-up (94 vs. 75%; p = 0.003). With regard to recurrence of pseudocysts, patients had an elevated rate of reoperations following drainage procedure (13 vs. 1%; p = 0.008). The endocrine function was significantly better preserved in patients of the drainage group compared to the resection group (no diabetes 67 vs. 35%, p < 0.01).


CONCLUSIONS
The resection has, compared to drainage procedures alone, the advantage of low recurrence rate of pseudocysts and a high rate of pain-free patients in the long-term follow-up. However, the risk of diabetes is increased in the resection group.
Schlosser
Wolfgang
W
Department of General Surgery, University of Ulm, Ulm, Germany. wolfgang.schlosser@medizin.uni-ulm.de
Siech
Marco
M
Beger
Hans G
HG
D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D004322:Drainage; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010192:Pancreatic Pseudocyst / Q000401:mortality / Q000601:surgery*; D010195:Pancreatitis / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome