title: Dialytic performance evaluation of Rexeed: a new polysulfone-based dialyzer with improved flow distributions.
abstract: New dialyzers are designed to optimize the convective and diffusive components of solute transport. Asahi Kasei Medical Co.,Ltd.has developed a new high flux dialyzer series called Rexeed with improved flow distributions. We evaluated the in vivo dialytic performance of two dialyzers of the Rexeed series: Rexeed-18A and Rexeed-25A (1.8 m2 and 2.5 m2 ). We calculated the clearance for urea,creatinine,phosphate and b2-microglobulin both in high flux dialysis (HFD)and in 15 liter postidiluitional on-line hemodiafiltration (HDF)mode. With n = 3 patients in high flux HD at blood flow 450, 400, 350 and 250 ml/min we found remarkably high clearance for urea (347 +/- 4%, 305 +/- 0%, 288 +/- 5%, 230 +/- 3%, for Rexeed-18A and 361 +/- 3%, 329 +/- 0%, 313 +/- 1%, 234 +/- 3%for Rexeed-25A),creatinine (282 +/- 10%, 234 +/- 0%, 221 +/- 8%, 174 +/- 8%, for Rexeed-18A and 276 +/- 6%, 245 +/- 0%, 226 +/- 9%, 172 +/- 13% for Rexeed-25A),phosphate (347 +/- 0%, 316 +/- 0%, 275 +/- 4%, 202 +/- 16%, for Rexeed-18A and 364 +/- 3%, 365 +/- 0%,286 +/- 3%, 224 +/- 2% for Rexeed-25A)and b2-microglobulin (133 +/- 21%, 124 +/- 0%,118 +/- 12%, 98 +/- 11%, for Rexeed-18A and 159 +/- 8%, 169 +/- 0%,157 +/- 8%, 129 +/- 7% for Rexeed-25A) With n = 2 patients in HDF at blood flow 300 ml/min we found remarkably high clearance for urea (268 +/- 2%, for Rexeed-18A and 283 +/- 2% for Rexeed-25A),creatinine (183 +/- 6%for Rexeed-18A and 205 +/- 9% for Rexeed-25A),phosphate (245 +/- 3%, for Rexeed-18A and 270 +/- 2% for Rexeed-25A)and b2-microglobulin (166 +/- 12%, for Rexeed-18A and 192 +/- 4% for Rexeed-25A). Our preliminary evaluation describes the characteristics and the performances of a new polysulfone-based hemodialyzer series called Rexeed. Several innovative features have been implemented by the manufacturer. These constructive approaches seem to have produced a positive effect on the dialyzer performance at the bedside.
authors.affiliation: Department of Nephrology, St. Bortolo Hospital, Vicenza--Italy. Alessandra.brendolan@ulssvicenza.it
authors.forename: A
authors.initials: A
authors.lastname: Brendolan
authors.forename: F
authors.initials: F
authors.lastname: Nalesso
authors.forename: A
authors.initials: A
authors.lastname: Fortunato
authors.forename: C
authors.initials: C
authors.lastname: Crepaldi
authors.forename: M
authors.initials: M
authors.lastname: De Cal
authors.forename: S
authors.initials: S
authors.lastname: Cazzavillan
authors.forename: D
authors.initials: D
authors.lastname: Cruz
authors.forename: N
authors.initials: N
authors.lastname: Techawathanawanna
authors.forename: C
authors.initials: C
authors.lastname: Ronco
mesh_terms: D001783:Blood Flow Velocity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000628:therapy*; D008567:Membranes, Artificial; D010865:Pilot Projects; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods; D012212:Rheology / Q000295:instrumentation* / Q000379:methods; D013450:Sulfones; D016896:Treatment Outcome
chemical_list: D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700