New cytotoxic benzopyrans from the leaves of Mallotus apelta.
Two new benzopyrans 6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1'-oxo-3'(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1 D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC50: 0.49 microg/mL) and rhabdosarcoma (RD, IC50: 0.54 microg/mL), while compound 2 showed moderate activity against Hep-2 cell line (IC50, 4.22 microg/mL) by in vitro assay.
Kiem
Phan Van
PV
Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, Hanoi, Vietnam.
Dang
Nguyen Hai
NH
Bao
Ha Viet
HV
Huong
Hoang Thanh
HT
Minh
Chau Van
CV
Huong
Le Mai
le M
Lee
Jung Joon
JJ
Kim
Young Ho
YH
D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*
C506377:6-(1'-oxo-3'(R)-hydroxy-butyl)-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran; C506375:6-(1'-oxo-3'(R)-methoxy-butyl)-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran; D001578:Benzopyrans; D010936:Plant Extracts