Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs).
The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.
Fairlamb
Ian J S
IJ
Department of Chemistry, University of York, Heslington, York YO10 5DD, UK. ijsf1@york.ac.uk
Duhme-Klair
Anne-Kathrin
AK
Lynam
Jason M
JM
Moulton
Benjamin E
BE
O'Brien
Ciara T
CT
Sawle
Philip
P
Hammad
Jehad
J
Motterlini
Roberto
R
D000818:Animals; D002248:Carbon Monoxide / Q000737:chemistry / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D005290:Ferric Compounds / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*; D013997:Time Factors
D005290:Ferric Compounds; D008024:Ligands; D011753:Pyrones; D002248:Carbon Monoxide; D007501:Iron