title: Prothrombin G20210A gene variant is not associated with idiopathic portal vein thrombosis in an area endemic for portal vein thrombosis.
abstract: Prothrombin G20210A gene variant has been found in 0-23% of patients with portal vein thrombosis (PVT). This wide variation makes it difficult to assess the importance of prothrombin G20210A gene variant as a predisposing factor for PVT. In this study from South India, none of the patients with idiopathic PVT (0/38) or any of the controls (0/46) had prothrombin G20210A gene variant. Prothrombin G20210A gene variant does not contribute to the development of PVT in India.
authors.affiliation: Department of Gastroenterology, Institute of Population Health and Clinical Research, St John's Medical College Hospital, Bangalore, India. koshyabe@yahoo.com
authors.forename: Abraham
authors.initials: A
authors.lastname: Koshy
authors.forename: Mary
authors.initials: M
authors.lastname: Jeyakumari
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011169:Portal Vein / Q000473:pathology*; D011516:Prothrombin / Q000235:genetics*; D020246:Venous Thrombosis / Q000209:etiology / Q000235:genetics*
chemical_list: D011516:Prothrombin