title: Screening of plants used in Danish folk medicine to treat epilepsy and convulsions.
abstract: Aqueous and ethanolic extracts of 42 plants used in Danish folk medicine for the treatment of epilepsy and convulsions, or for inducing sedation, were tested for affinity to the GABA(A)-benzodiazepine receptor in the flumazenil-binding assay. Ethanolic extracts of leaves of Primula elatior and Primula veris and aerial parts of Tanacetum parthenium exhibited good, dose-dependent affinity.
authors.affiliation: Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, 2100 Copenhagen O, Denmark. ankj@dfuni.dk
authors.forename: Anna K
authors.initials: AK
authors.lastname: Jäger
authors.forename: Bente
authors.initials: B
authors.lastname: Gauguin
authors.forename: Anne
authors.initials: A
authors.lastname: Adsersen
authors.forename: Lene
authors.initials: L
authors.lastname: Gudiksen
mesh_terms: D003718:Denmark; D004827:Epilepsy / Q000628:therapy*; D008519:Medicine, Traditional; D010946:Plants, Medicinal / Q000145:classification*; D012640:Seizures / Q000628:therapy*