title: Measurement of whole blood viscosity profiles via an automated viscometer: technical details and clinical relevance.
abstract: Recent basic science and large-scale clinical studies involving blood rheological factors have led to a similar conclusion: the mechanics of blood flow play an important role in the development and progression of various cardiovascular diseases (e.g., coronary artery disease, stroke). Several viscometer systems to measure whole blood viscosity have been developed, yet blood viscosity measurements are not routinely employed in clinical practice, primarily due to the complexity of currently available methods. Herein we provide a description of a new, computer-controlled capillary viscometer that offers a convenient approach to the measurement of blood viscosity over a wide range of shear rates. The new viscometer uses a disposable test section, requires small volumes of blood, provides viscosity data that compare well with those from other viscometers, and completes all testing and data analysis within five minutes.
authors.affiliation: Department of Physiology and Biophysics, Keck School of Medicine, Los Angeles, CA 90033, USA. alexy@usc.edu
authors.forename: Tamas
authors.initials: T
authors.lastname: Alexy
authors.forename: Eszter
authors.initials: E
authors.lastname: Pais
authors.forename: Rosalinda B
authors.initials: RB
authors.lastname: Wenby
authors.forename: William
authors.initials: W
authors.lastname: Hogenauer
authors.forename: Kalman
authors.initials: K
authors.lastname: Toth
authors.forename: Herbert J
authors.initials: HJ
authors.lastname: Meiselman
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Kensey
mesh_terms: D001809:Blood Viscosity; D002318:Cardiovascular Diseases / Q000175:diagnosis; D006403:Hematologic Tests / Q000295:instrumentation; D018056:Hemorheology / Q000295:instrumentation*; D006801:Humans