title: The anti-thrombotic activity of surfactins.
abstract: Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents.
authors.affiliation: College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Jong-hwan
authors.initials: JH
authors.lastname: Lim
authors.forename: Byung-kwon
authors.initials: BK
authors.lastname: Park
authors.forename: Myoung-seok
authors.initials: MS
authors.lastname: Kim
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Hwang
authors.forename: Man-Hee
authors.initials: MH
authors.lastname: Rhee
authors.forename: Seung-Chun
authors.initials: SC
authors.lastname: Park
authors.forename: Hyo-in
authors.initials: HI
authors.lastname: Yun
mesh_terms: D001412:Bacillus subtilis / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology
chemical_list: D005343:Fibrinolytic Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors; C009365:surfactin peptide