Mifepristone may inhibit the midcycle gonadotropin surge at both ovarian and pituitary sites of action.
The ability of mifepristone to delay ovulation is thought to be based on the antigonadotropic effects of the drug. In the current work, late-follicular phase administration of mifepristone resulted in decrease in both circulating FSH and inhibin B, suggesting both central and ovarian sites of action.
Heikinheimo
Oskari
O
Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland. oskari.heikinheimo@helsinki.fi
Leminen
Riikka
R
Raivio
Taneli
T
D005260:Female; D005498:Follicular Phase / Q000097:blood / Q000187:drug effects*; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism
D006062:Gonadotropins; D015735:Mifepristone