title: [Physiopathological mechanisms in tinnitus generation and persistence].
abstract: Progress in neuroscience research has given birth to new theories for tinnitus generation. From a point of view where cochlear dysfunctions would be considered as the origin and maintenance mechanisms, it has been introduced the important role of compensation systems from the central auditory pathways. They could act as the most relevant factor for chronic persistent tinnitus after a peripheral aggression. Unmasking of silent synapses or sprouting of new ones activate cortical reorganization for frecuencial areas nearby the non-stimulated ones through brain plasticity. Connections to associative cortex and limbic-amigdala area using the non-classical auditory system explain the presence of hyperacusis, anxiety or depression, factors that increase the severity of tinnitus. Implementation of these physiopathological theories reinforces the tinnitus neurophysiological model. The development of an aversive response through the survival reflex and the participation of negative emotional response are the responsible for signal persistence and vegetative reactions from the autonomous nervous system. Implications of this knowledge for tinnitus treatment involve the central auditory system approach through the combination of medical counselling for reduction of the aversive reaction and sound therapy to diminish its perception.
authors.affiliation: Unidad de Acufenos, Instituto ORL Antoli-Candela, Madrid. cherraizp@seorl.net
authors.forename: C
authors.initials: C
authors.lastname: Herraiz
mesh_terms: D003051:Cochlea / Q000503:physiopathology; D006801:Humans; D012720:Severity of Illness Index; D014012:Tinnitus / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy