title: Redox-dependent transcriptional regulation.
abstract: Reactive oxygen species contribute to the pathogenesis of a number of disparate disorders including tissue inflammation, heart failure, hypertension, and atherosclerosis. In response to oxidative stress, cells activate expression of a number of genes, including those required for the detoxification of reactive molecules as well as for the repair and maintenance of cellular homeostasis. In many cases, these induced genes are regulated by transcription factors whose structure, subcellular localization, or affinity for DNA is directly or indirectly regulated by the level of oxidative stress. This review summarizes the recent progress on how cellular redox status can regulate transcription-factor activity and the implications of this regulation for cardiovascular disease.
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liu
authors.forename: Renata
authors.initials: R
authors.lastname: Colavitti
authors.forename: Ilsa I
authors.initials: II
authors.lastname: Rovira
authors.forename: Toren
authors.initials: T
authors.lastname: Finkel
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology; D001426:Bacterial Proteins / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D029968:Escherichia coli Proteins / Q000502:physiology; D006655:Histone Deacetylases / Q000502:physiology; D006801:Humans; D000072019:Kelch-Like ECH-Associated Protein 1; D009243:NAD / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000502:physiology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D012097:Repressor Proteins / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D056564:Sirtuin 1; D037761:Sirtuins / Q000502:physiology; D018808:Transcription Factor AP-1 / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C117301:Keap1 protein, mouse; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; D017382:Reactive Oxygen Species; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D018808:Transcription Factor AP-1; D014157:Transcription Factors; C086677:YAP1 protein, S cerevisiae; C499299:oxyR protein, E coli; D009243:NAD; C070724:SoxR protein, Bacteria; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins; D006655:Histone Deacetylases; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase