Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.
Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.
Zhang
Linqi
L
The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA. lzhang@adarc.org
Zhang
Fengwen
F
Yu
Wenjie
W
He
Tian
T
Yu
Jian
J
Yi
Christopher E
CE
Ba
Lei
L
Li
Wenhui
W
Farzan
Michael
M
Chen
Zhiwei
Z
Yuen
Kwok-Yung
KY
Ho
David
D
D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000086462:Coronavirus Nucleocapsid Proteins; D018450:Disease Progression; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology; D009500:Neutralization Tests; D019590:Nucleocapsid Proteins / Q000276:immunology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000503:physiopathology; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000276:immunology
D000914:Antibodies, Viral; D000086462:Coronavirus Nucleocapsid Proteins; D008562:Membrane Glycoproteins; D019590:Nucleocapsid Proteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; C578557:spike glycoprotein, SARS-CoV