Lack of association of glutathione S-transferase P1 Ile105Val polymorphism with aspirin-intolerant asthma.
BACKGROUND
Glutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be associated with asthma related phenotypes such as atopy and bronchial hyperresponsiveness. Therefore we investigated whether this polymorphism may be associated with the development of aspirin-intolerant asthma (AIA).


METHODS
GSTP1 Ile105Val polymorphism was determined using a single based extension method in 88 AIA subjects and compared to 154 aspirin-tolerant asthma (ATA) subjects and 119 normal healthy controls (NC) recruited from the Korean population.


RESULTS
No significant differences in allele and genotype frequencies of the GSTP1 Ilel105Val polymorphism were observed in the three groups (p>0.05). However, minor G allele frequency of the GSTP1 Ilel105Val polymorphism in AIA group (16.5%) tended to be lower than in the NC group (20.6%).


CONCLUSIONS
These results suggest a lack of association of the GSTPI Ilel105Val gene polymorphism with AIA phenotype in the Korean population [word count: 159].
Oh
Jung-Mi
JM
Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea.
Kim
Seung-Hyun
SH
Suh
Chang-Hee
CH
Nahm
Dong-Ho
DH
Park
Hae-Sim
HS
Lee
Young-Mok
YM
Lee
June-Hyuk
JH
Park
Choon-Sik
CS
Shin
Hyung-Doo
HD
D000328:Adult; D000483:Alleles; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D005978:Glutathione / Q000378:metabolism*; D051549:Glutathione S-Transferase pi / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D007723:Korea; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005978:Glutathione; D001241:Aspirin