AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.
An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.
Gao
Xiaojiang
X
Laboratory of Genomic Diversity, NCI-Frederick, Basic Research Program, SAIC Frederick, P.O. Box B, Frederick, Maryland 21702, USA.
Bashirova
Arman
A
Iversen
Astrid K N
AK
Phair
John
J
Goedert
James J
JJ
Buchbinder
Susan
S
Hoots
Keith
K
Vlahov
David
D
Altfeld
Marcus
M
O'Brien
Stephen J
SJ
Carrington
Mary
M
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000276:immunology*; D000483:Alleles; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018450:Disease Progression; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D016019:Survival Analysis; D013997:Time Factors
D015235:HLA-B Antigens