Radical scavengers: a remedy for presbyacusis. A pilot study.
CONCLUSIONS
The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for presbyacusis.


OBJECTIVE
To assess the efficacy of treatment with the radical scavengers rebamipide and vitamin C for presbyacusis.


METHODS
Rebamipide (300 mg/day) and vitamin C (600 mg/day) were taken orally for at least 8 weeks by 23 patients with presbyacusis.


RESULTS
Hearing levels after treatment were significantly improved at 125, 250, 500 and 8000 Hz but unchanged at 1000, 2000 and 4000 Hz.
Takumida
Masaya
M
Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan. masati@ipc.hiroshima-u.ac.jp
Anniko
Matti
M
D000368:Aged; D000369:Aged, 80 and over; D000409:Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001299:Audiometry; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011304:Presbycusis / Q000175:diagnosis* / Q000188:drug therapy*; D011336:Probability; D015363:Quinolones / Q000627:therapeutic use*; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D016166:Free Radical Scavengers; D015363:Quinolones; C052785:rebamipide; D000409:Alanine; D001205:Ascorbic Acid