title: Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata.
abstract: The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema was significantly reduced by all the doses of the extract administered, with the 200 mg/kg dose producing the highest oedema inhibition (80.5%). In the cotton pellet method, granuloma weight was significantly reduced from 14 +/- 0.1 to 9.0 +/- 0.1 mg, while in the formaldehyde induced arthritis the extract inhibited the oedema during the 10-day period. In conclusion, this study has established the anti-inflammatory activity of C. odorata and, thus, justifies the traditional uses of the plant in the treatment of wounds and inflammation.
authors.affiliation: Department of Physiology and Biochemistry, University of Ilorin, 1515 Ilorin, Nigeria. deleyele@yahoo.com
authors.forename: Victor B
authors.initials: VB
authors.lastname: Owoyele
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Adediji
authors.forename: Ayodele O
authors.initials: AO
authors.lastname: Soladoye
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D036604:Chromolaena; D004305:Dose-Response Relationship, Drug; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts