Highly enantioselective Biginelli reaction using a new chiral ytterbium catalyst: asymmetric synthesis of dihydropyrimidines.
The highly enantioselective three-component Biginelli condensation catalyzed by a recyclable chiral ytterbium triflate with a novel hexadentate amine phenol ligand containing a pyridyl group has been developed. A wide range of optically active dihydropyrimidines with remarkable pharmacological interest was obtained in high yields with good to excellent enantioselectivities under mild conditions.
Huang
Yijun
Y
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
Yang
Fengyue
F
Zhu
Chengjian
C
D002384:Catalysis; D008956:Models, Chemical; D008958:Models, Molecular; D011743:Pyrimidines / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013871:Thiones / Q000037:antagonists & inhibitors; D015018:Ytterbium / Q000737:chemistry*
D011743:Pyrimidines; D013871:Thiones; C400223:monastrol; D015018:Ytterbium