SERS studies of the adsorption of guanine derivatives on gold colloidal nanoparticles.
Surface enhanced Raman scattering spectra of guanine, guanosine and 2'-deoxyguanosine adsorbed on gold colloidal nanoparticles were obtained. From the striking similarity of the SERS spectra of these compounds, it can be evidenced that guanosine and 2'-deoxyguanosine adsorb on gold nanoparticles through the guanine moiety. The molecular sites involved in the interaction with the gold surface are the same for the 3 compounds: the oxygen of the carbonilic group and the N(7) atom. Guanine, guanosine and 2'-deoxyguanosine adsorb on the gold substrates with a tilted orientation with respect to the metal surface. SERS data were interpreted taking into account density functional theoretical (DFT) calculations of guanine.
Pergolese
Barbara
B
Department of Chemical Sciences, University of Trieste, Via L. Giorgieri 1, I-34127 Trieste, Italy. pergoles@dsch.univ.trieste.it
Bonifacio
Alois
A
Bigotto
Adriano
A
D000327:Adsorption; D003102:Colloids / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
D003102:Colloids; D006147:Guanine; D006046:Gold