Identification by 15N refocused INADEQUATE MAS NMR of intermolecular hydrogen bonding that directs the self-assembly of modified DNA bases.
15N solid-state NMR refocused INADEQUATE spectra of two lipophilic deoxyguanosine derivatives unambiguously identify different intermolecular hydrogen-bonding arrangements that are indicative of either guanine ribbon or quartet self-assembly. The observation of guanine quartet formation in the absence of metal ions is a further example that challenges the accepted dogma that quartet formation requires metal ions.
Pham
Tran N
TN
Department of Physics, University of Warwick, Coventry CV4 7AL, UK.
Masiero
Stefano
S
Gottarelli
Giovanni
G
Brown
Steven P
SP
D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009584:Nitrogen / Q000378:metabolism*; D009587:Nitrogen Isotopes
D009587:Nitrogen Isotopes; D004247:DNA; D009584:Nitrogen