Medication use as a risk factor for falls among hospitalized elderly patients.
OBJECTIVE
The relationship between medication use and falls among hospitalized elderly patients was studied.


METHODS
Sixty-two patients 65 years of age or older who fell during hospitalization were randomly selected from incident reports of falls and matched for age, sex, and discharge date with 62 patients who did not fall. Data on demographic characteristics, vital signs, laboratory test variables, drug therapy, and the presence of other known risk factors for falls were collected retrospectively and compared between the groups.


RESULTS
Nonsteroidal antiinflammatory drug (NSAID) use was more frequent in patients who fell than in control patients. NSAID use was a significant predictor of falls and was associated with a 10-fold increase in the likelihood of falling. Opioid analgesics were given more frequently to control patients and were not associated with falls. Dementia, the only non-medication-related independent predicator of falls, was associated with a 21-fold greater risk of falling.


CONCLUSIONS
In hospitalized elderly patients, there was a significant association between NSAID use and falls, an effect largely accounted for by low-dose aspirin.
Walker
Paul C
PC
Department of Pharmacy Services, College of Pharmacy, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0008, USA. pcwalker@umich.edu
Alrawi
Ahmad
A
Mitchell
John F
JF
Regal
Randolph E
RE
Khanderia
Ujjaini
U
D000058:Accidental Falls / Q000706:statistics & numerical data*; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D016022:Case-Control Studies; D003704:Dementia / Q000150:complications; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006746:Hospital Bed Capacity, 500 and over; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012306:Risk; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal