[A comparative study of the development of drug differentiation between mexidol and phenazepam].
Interceptive stimulus properties of mexidol (50 and 100 mg/kg, i.p.) and phenazepam (2 mg/kg, i.p.) were compared using the standard operant model of liquid-reinforced drug discrimination (DD) procedure in male albino rats. Successful DD development has been shown in 100% of phenazepam-pretreated rats, while only 10% of mexidol-treated animals demonstrated DD. In the case of a high stimulus control, both mexidol and phenazepam DD manifestations showed high reproducibility (not less than 80% adequate reactions) and stability. The results suggest that mexidol, while possessing interceptive stimulus properties, belongs to the group of moderately discriminated psychotropic drugs.
Kalinina
T S
TS
Voronina
T A
TA
Petrianina
E V
EV
D000818:Animals; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D010847:Picolines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D010847:Picolines; D001569:Benzodiazepines; C070020:emoxypine succinate; C017928:phenazepam