Zwitterionic latex particles as an effective carrier for DNA.
The ability of small particles to associate with DNA and to transport it to desired targets without being subjected to interferences can make them efficient vehicles for gene delivery. Keeping these requirements in mind, zwitterionic latex particles with two different functional tethers were chosen for studying their interaction with DNA as vehicle complexes. From adsorption and electrokinetic studies, it is evident that zwitterionic latex particles can have marked association with DNA. Moreover, DNA-latex complexation does not provoke undesired aggregation of latex particles. These characteristics are important for it to carry the DNA efficiently under changing media conditions.
Somasundaran
T
T
NSF IUCR Center for Advanced Studies in Novel Surfactants, Langmuir Center for Colloid and Interfaces, Columbia University, New York, NY 10027, USA.
Deo
Namita
N
Somasundaran
P
P
D000327:Adsorption; D004247:DNA / Q000493:pharmacokinetics*; D018014:Gene Transfer Techniques / Q000295:instrumentation; D005822:Genetic Vectors; D007840:Latex; D008863:Microspheres
D007840:Latex; D004247:DNA