title: Hepatic cirrhosis caused by low-dose oral amiodarone therapy.
abstract: A 63-year-old man presented with ascites after therapy with amiodarone, 200 mg orally once per day for 22.5 months. A liver biopsy showed grade 3 chronic hepatitis and micronodular cirrhosis. The presence of striking microvesicular steatosis on light microscopy and lysosomal inclusion bodies on electron microscopy suggested amiodarone hepatotoxicity. This is the first reported case of amiodarone-induced hepatic cirrhosis associated with chronic treatment with 200 mg orally once per day for less than 2 years.
authors.affiliation: Department of Medicine, St. John's Mercy Medical Center, St. Louis, Missouri 63141, USA.
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Puli
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Fraley
authors.forename: Vanaja
authors.initials: V
authors.lastname: Puli
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Kuperman
authors.forename: Martin A
authors.initials: MA
authors.lastname: Alpert
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone