G-protein signaling in iNOS gene expression.
Heterotrimeric G proteins are the molecular switches in the receptor-mediated transmembrane signaling system. Inducible nitric oxide synthase (iNOS) is inducible by a variety of inflammatory stimuli, which leads to vascular hyporeactivity. In this chapter, the system to study the cell signaling pathways downstream of the GPCR coupling to G proteins is described for the study of iNOS gene expression. The cellular signaling pathways by which ligand induces iNOS may serve as the pharmacological targets for preventing or treating vascular hyporeactivity.
Kim
Sang Geon
SG
College of Pharmacy, Seoul National University, Kwanak-gu, Seoul, South Korea.
Lee
Chang Ho
CH
D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western; D002460:Cell Line; D015342:DNA Probes; D015870:Gene Expression; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D015398:Signal Transduction
D015342:DNA Probes; D052247:Nitric Oxide Synthase Type II; D020962:Heterotrimeric GTP-Binding Proteins