Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo.
Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian cells. Recent reports have shown that PTDs can mediate the delivery of cargo to tissues throughout a living organism. Such technology could eliminate the size restrictions on usable drugs, so enabling previously unavailable large molecules to modulate in vivo biology and alleviate disease. This article will review the evidence that PTDs can be used both to deliver active molecules to pathological tissue in vivo and to treat models of disease such as cancer, ischaemia and inflammation.
Snyder
Eric L
EL
UCSD School of Medicine, Howard Hughes Medical Institute and Department of Cellular & Molecular Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0686, USA.
Dowdy
Steven F
SF
D000818:Animals; D016503:Drug Delivery Systems; D015316:Genetic Therapy / Q000379:methods; D018398:Homeodomain Proteins / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D007511:Ischemia / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D009696:Nucleic Acids / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use; D010455:Peptides / Q000008:administration & dosage* / Q000627:therapeutic use; D017434:Protein Structure, Tertiary; D021381:Protein Transport / Q000502:physiology; D011506:Proteins / Q000008:administration & dosage* / Q000627:therapeutic use
D018398:Homeodomain Proteins; D009696:Nucleic Acids; D010455:Peptides; D011506:Proteins