The design and synthesis of a herbicide targeted library of N-[1-(1,3-benzoxazol-2-yl)alkyl]-6-alkyl-1,3,5-triazine-2,4-diamines.
Amino acids were immobilised by attaching them via a carbamate linker to Wang resin. These intermediates were converted to 1-(1,3-benzoxazol-2-yl)alkanamines over three steps, followed by coupling with 4-alkyl-6-chloro-1,3,5-triazine-2-amines to furnish the desired N-[1-(1,3-benzoxazol-2-yl)alkyl]-6-alkyl-1,3,5-triazine-2,4-diamines. Physico-chemical property profiles were used to support design and development of a combinatorial library. The synthetic methodology described herein was validated with the production of a herbicide targeted library of 300 members.
Dietrich
Hansjörg
H
Bayer CropScience GmbH, Department of Chemistry, Industriepark Höchst, G836, D-65926 Frankfurt am Main, Germany.
Giencke
Wolfgang
W
Klein
Robert
R
D016573:Agrochemicals / Q000138:chemical synthesis; D002622:Chemistry, Agricultural / Q000379:methods; D020650:Combinatorial Chemistry Techniques; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006540:Herbicides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D016573:Agrochemicals; D003959:Diamines; D006540:Herbicides