title: [Two cases of Bartholin's gland abscesses caused by Streptococcus pneumoniae and Haemophilus influenzae].
abstract: Most of Bartholin's gland abscesses have been thought to be caused by microorganisms found in opportunistic infections. However, we have encountered two very interesting cases of Bartholin's gland abscesses caused by Streptococcus pneumoniae and Haemophilus influenzae, two major pathogens of respiratory tract infections. In the first case, since abscess formation was not observed due to disintegration, cefdinir (CFDN), 300 mg/day, t.i.d. for 5 days was administered. The treatment improved clinical symptoms, but relapse occurred 3 days after the administration was discontinued. Microbiological examination of pus revealed the presence of Streptococcus pneumoniae and Finegoldia magna, and it also showed that the isolated S. pneumoniae was penicillin-resistant S. pneumoniae (PRSP). After an incision and drainage of abscess, cefteram pivoxil (CFTM-PI), 300 mg/day t.i.d. for 7 days, was administered, and the cure was confirmed. In the second case, after an incision and drainage of Bartholin's gland abscess, amoxicillin (AMPC), 750 mg/day, t.i.d. for 5 days, was administered. The treatment improved clinical symptoms temporarily. However, the symptoms deteriorated 7 days after the operation, and the patient was diagnosed with relapse. Microbiological examination of pus revealed the presence of Haemophilus influenzae and Peptostreptococcus anaerobius, and it also showed that the isolated H. influenzae was beta-lactamase-nonproducing ampicillin-resistant H. influenzae (BLNAR). After performing additional incision and drainage of abscess again, CFTM-PI, 300 mg/day, t.i.d. for 7 days, was administered, and the cure was confirmed. In addition, the analysis of these two cases using PK/PD theory revealed that the time above MIC reached 100% with administration of CFTM-PI 300mg, t.i.d. suggesting that the dosage is sufficient for treating these infections. There are other cases of external genitalia infections caused by microorganisms usually associated with respiratory tract infections like cases that we are reporting here. Therefore, it is necessary to consider a possible infection by drug-resistant bacteria even for a case of external genitalia infection. In addition, it was thought that adjusting dosage and method for administration of antibacterial agents based on PK/PD theory would help to rovide efficient treatment.
authors.affiliation: Division of Anaerobe Research, Life Science Research Center, Gifu University.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Tamaya
authors.forename: Kaori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kunitomo
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000038:Abscess / Q000382:microbiology*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001472:Bartholin's Glands; D024881:Drug Resistance, Bacterial; D005260:Female; D006192:Haemophilus Infections / Q000188:drug therapy / Q000382:microbiology*; D006193:Haemophilus influenzae; D006801:Humans; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D014845:Vulvar Diseases / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents