Notch signaling in hematopoietic stem cells.
The molecular basis of the hematopoietic stem cell (HSC) "niche" has gradually been elucidated. This new knowledge may help us understand how the self-renewal of HSCs is physiologically regulated and may give us clues for developing methods for ex vivo HSC expansion. The Notch pathway is an environmental signaling system that may play an important role in the HSC niche. In this review, we focus on the role of Notch signaling in the regulation of hematopoietic stem and progenitor cells in both embryo and adult hematopoiesis and clarify what is known regarding the self-renewal of HSCs.
Suzuki
Takahiro
T
Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, Japan.
Chiba
Shigeru
S
D000818:Animals; D047108:Embryonic Development; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008322:Mammals; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D051880:Receptors, Notch