title: The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population.
abstract: The HLA-Cw*0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw*0602 nor the allele CDSN*TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1_4_4 (OR = 2.6, 95% CI = 1.4-4.7, p(c) = 0.018) the octamer transcription factor (OTF)-3 gene (OR = 2.6, 95% CI = 1.6-4.3, p(c) = 0.0001) and the alpha-helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3-4.5, p(c) = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene.
authors.affiliation: Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Martínez-Borra
authors.forename: Chaim
authors.initials: C
authors.lastname: Brautbar
authors.forename: Segundo
authors.initials: S
authors.lastname: González
authors.forename: Claes D
authors.initials: CD
authors.lastname: Enk
authors.forename: Antonio
authors.initials: A
authors.lastname: López-Vázquez
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Larrea
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002503:Centromere / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007557:Israel; D007585:Jews / Q000235:genetics*; D008297:Male; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D011565:Psoriasis / Q000208:ethnology* / Q000235:genetics*; D016615:Telomere / Q000235:genetics*
chemical_list: C109656:CDSN protein, human; D006023:Glycoproteins; D015236:HLA-C Antigens; D036341:Intercellular Signaling Peptides and Proteins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human