Receptor-mediated clearance of Cryptococcus neoformans capsular polysaccharide in vivo.
Cryptococcus neoformans capsular glucuronoxylomannan (GXM) is shed during cryptococcosis and taken up by macrophages. The roles of the putative GXM receptors CD14, CD18, Toll-like receptor 2 (TLR2), and TLR4 in GXM clearance from serum and deposition in the liver and spleen in receptor-deficient mice were studied. While alterations in the kinetics of GXM redistribution were seen in the mutant mice, none of the receptors was absolutely required for serum clearance or hepatosplenic accumulation.
Yauch
Lauren E
LE
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Mansour
Michael K
MK
Levitz
Stuart M
SM
D000818:Animals; D016667:Bacterial Capsules / Q000737:chemistry / Q000378:metabolism*; D003453:Cryptococcosis / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D003455:Cryptococcus neoformans / Q000472:pathogenicity*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D011134:Polysaccharides / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology*; D013154:Spleen / Q000378:metabolism
D011134:Polysaccharides; D011971:Receptors, Immunologic; C027478:glucuronoxylomannan