Effect of ubiquinone Q(10) and antioxidant vitamins on free radical oxidation of phospholipids in biological membranes of rat liver.
We studied the effects of 30-day peroral treatment with beta-carotene, a complex of antioxidant vitamins (vitamins C and E and provitamin A) and selenium, and solubilized ubiquinone Q(10) on the antioxidant potential in rat liver (ascorbate-dependent free radical oxidation of unsaturated membrane phospholipids). beta-Carotene irrespective of the administration route increased antioxidant potential of the liver by 2-3.5 times. The complex of antioxidant vitamins and selenium increased this parameter by more than 15 times. Antiradical activity in rat liver was extremely high after administration of solubilized ubiquinone Q(10) (increase by more than by 36 times). It can be expected that reduced ubiquinone Q(10) in vivo should produce a more pronounced protective effect due to activity of the system for bioregeneration of this natural antioxidant.
Tikhaze
A K
AK
A. L. Myasnikov Institute of Cardiology; Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health, Moscow.
Konovalova
G G
GG
Lankin
V Z
VZ
Kaminnyi
A I
AI
Kaminnaja
V I
VI
Ruuge
E K
EK
Kukharchuk
V V
VV
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D003067:Coenzymes; D005609:Free Radicals; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008110:Liver Extracts / Q000378:metabolism; D008297:Male; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010743:Phospholipids / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014815:Vitamins; D019207:beta Carotene / Q000378:metabolism
D000975:Antioxidants; D003067:Coenzymes; D005609:Free Radicals; D008110:Liver Extracts; D010743:Phospholipids; D014815:Vitamins; D019207:beta Carotene; D014451:Ubiquinone; C024989:coenzyme Q10; D001205:Ascorbic Acid; D010100:Oxygen