Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent.
3',4',5'-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The product 8 showed significant anticancer activity against human cancer cell lines COLO320DM (colon), CaCO2 (colon) and WRL68 (liver) at 0.7, 0.65 and 0.50 microg/ml concentrations, respectively, in the in vitro MTT assay.
Srivastava
Vandana
V
Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, Kukrail Road, Lucknow 226 015, India.
Negi
Arvind S
AS
Kumar
J K
JK
Faridi
Uzma
U
Sisodia
Brijesh S
BS
Darokar
M P
MP
Luqman
Suaib
S
Khanuja
S P S
SP
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C509743:1-(3',4',5'-trimethoxy)phenylnaphtho(2,1b)furan; D000970:Antineoplastic Agents; D005663:Furans