title: Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents.
abstract: The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
authors.affiliation: Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis (U.N.S.L.), Chacabuco 917, 5700 San Luis, Argentina.
authors.forename: Fernando D
authors.initials: FD
authors.lastname: Suvire
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Sortino
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Kouznetsov
authors.forename: Leonor Y
authors.initials: LY
authors.lastname: Vargas M
authors.forename: Susana A
authors.initials: SA
authors.lastname: Zacchino
authors.forename: Uriel Mora
authors.initials: UM
authors.lastname: Cruz
authors.forename: Ricardo D
authors.initials: RD
authors.lastname: Enriz
mesh_terms: D000499:Allylamine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects; D002478:Cells, Cultured; D003198:Computer Simulation; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D000499:Allylamine