Severe systemic hypersensitivity reaction to ibuprofen: a presentation of systemic lupus erythematosus.
We describe the first severe systemic hypersensitivity reaction to ibuprofen in a pediatric patient with previously undiagnosed systemic lupus erythematosus (SLE). An 11-year-old Thai male presented with fever, rash, altered mental status, and hypotension after oral administration of ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted in recurrence of presenting symptoms. Severe hypersensitivity with hypotension can be a rare consequence of the use of ibuprofen in children with collagen vascular disease. When encountered in an otherwise healthy child, a high index of suspicion must be maintained for the diagnosis of SLE.
Mou
Steven S
SS
Department of Pediatrics, University of Texas Southwestern Medical School, USA.
Punaro
Lynn
L
Antón
Jordi
J
Luckett
Peter M
PM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002648:Child; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000209:etiology; D007052:Ibuprofen / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen