title: [Kinetics model of spherical immobilized cellulase].
abstract: A kinetics model was developed for predicting and simulating immobilized cellulase performance, which follows Michaelis-Menten kinetics with competitive product inhibition. Taking into account the effects of competitive product inhibition, inner diffusional limitation, substrate concentration and carrier size, the substrate distribution and the product distribution in carriers were investigated, and the effectiveness factors were also calculated over a wide range of parameters. The effects of competitive product inhibition are shown to increase the substrate concentration in the carrier, and, additionally, to increase the effectiveness factors slightly. With the increase of inner diffusion coefficient, both the effectiveness factors and the substrate concentration in the carrier increase. As the carrier size increases, on the other hand, these values decrease. The effectiveness factors and the substrate concentration in the carrier are found to increase when substrate concentration in the reaction system increases.
authors.affiliation: School of Pharmacy, Soochow University, Suzhou 215007, China.
authors.forename: Jian-Qin
authors.initials: JQ
authors.lastname: Zhou
authors.forename: Shi-Gong
authors.initials: SG
authors.lastname: Chen
authors.forename: Zhong-Kui
authors.initials: ZK
authors.lastname: Zhu
mesh_terms: D002480:Cellulase / Q000378:metabolism*; D004058:Diffusion; D004800:Enzymes, Immobilized / Q000378:metabolism*; D007700:Kinetics; D008863:Microspheres; D008956:Models, Chemical; D010316:Particle Size; D013379:Substrate Specificity
chemical_list: D004800:Enzymes, Immobilized; D002480:Cellulase