title: Pitfalls in estimating piperaquine elimination.
abstract: By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.
authors.affiliation: Department of Pharmacology, Göteborg University, Sweden.
authors.forename: Joel
authors.initials: J
authors.lastname: Tarning
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegårdh
authors.forename: Anna
authors.initials: A
authors.lastname: Annerberg
authors.forename: Thida
authors.initials: T
authors.lastname: Singtoroj
authors.forename: Nicholas P J
authors.initials: NP
authors.lastname: Day
authors.forename: Michael
authors.initials: M
authors.lastname: Ashton
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D011804:Quinolines / Q000737:chemistry / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D010879:Piperazines
chemical_list: D000962:Antimalarials; D011804:Quinolines; C034759:piperaquine; D010879:Piperazines