VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.
A transferable plasmid from Klebsiella pneumoniae carried a class 1 integron containing bla(VIM-12), a novel bla(VIM)-type gene, flanked by two copies of aacA7. bla(VIM-12) was clustered between bla(VIM-1) and bla(VIM-2) and differed from bla(VIM-1) by 18 nucleotides that were all located at the 3' end and matched the corresponding nucleotides in bla(VIM-2). The bla(VIM-12)-associated 59-base element was identical to that described in bla(VIM-2) alleles.
Pournaras
Spyros
S
Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece. pournaras@med.uth.gr
Ikonomidis
Alexandros
A
Tzouvelekis
Leonidas S
LS
Tokatlidou
Despoina
D
Spanakis
Nicholas
N
Maniatis
Antonios N
AN
Legakis
Nicholas J
NJ
Tsakris
Athanassios
A
D000483:Alleles; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
C417264:VIM-1 metallo-beta-lactamase; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases; C525149:beta-lactamase VIM-12, Klebsiella pneumoniae