Cardiomyocytes derived from stem cells.
One way to restore failing heart function following myocardial infarction would be to replace lost or damaged cardiac cells by local or systemic injection. The sources of replacement cells presently discussed include embryonic stem cells, hematopoietic and non-hematopoietic stem cells from bone marrow or cord blood and small stem cell populations thought to reside in the heart itself or in skeletal muscle. Here we review this area of stem cell research with focus particularly on recent laboratory advances towards producing cardiomyocytes from embryonic stem cells. We conclude that embryonic stem cells and cardiac progenitors in the heart itself are the only proven sources of cardiomyocytes and that reported clinical effects of bone marrow stem currently undergoing validation are likely mediated by other mechanisms.
Van Laake
Linda W
LW
Hubrecht Laboratory (Netherlands Institute for Developmental Biology), Utrecht, Netherlands.
Van Hoof
Dennis
D
Mummery
Christine L
CL
D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D017690:Cell Transplantation / Q000379:methods; D006333:Heart Failure / Q000628:therapy; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000637:transplantation*; D013234:Stem Cells / Q000166:cytology*