Gabapentin-induced neurologic toxicities.
Gabapentin is an antiepileptic drug approved for the treatment of postherpetic neuralgia and as adjunctive therapy for partial seizures. The drug has been shown to be safe and nontoxic. The current literature has limited reports of neurologic toxicity associated with gabapentin therapy in patients with or without renal dysfunction. We describe the case of a 75-year-old man with renal dysfunction who developed neurologic toxicity due to gabapentin accumulation. Future studies are warranted to confirm the neurologic adverse effects of gabapentin, including any additional risks in patients with renal dysfunction.
Bookwalter
Thomas
T
Department of Pharmaceutical Services, University of California-San Francisco, San Francisco, California 94143-0622, USA. Thomas.Bookwalter@ucsfmedctr.org
Gitlin
Matthew
M
D058186:Acute Kidney Injury / Q000150:complications; D000368:Aged; D000588:Amines / Q000009:adverse effects* / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D051474:Neuralgia, Postherpetic / Q000150:complications / Q000188:drug therapy; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin