Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors.
The aim of the present work was to study the in vivo anti-inflammatory activity of six NSAIDs, ibuprofen, diclofenac, nimesulide, meloxicam, celecoxib and rofecoxib, using the rat air-pouch model of inflammation to characterize the ability of these drugs to induce gastric damage and PGE(2) inhibition. Selective compounds were observed to have no ulcerogenic properties at anti-inflammatory doses; however, these drugs were weaker inhibitors of several inflammatory aspects such as cell influx and exudate formation. In contrast, the non-selective and preferential compounds present anti-inflammatory properties at lower doses than presented by selective drugs. At anti-inflammatory doses, only meloxicam and ibuprofen produced gastric damage and inhibition of PGE(2) synthesis, suggesting that ulcerogenic properties of NSAIDs cannot be predicted by their selectivity index, since meloxicam demonstrates ulcerogenic properties despite its preferential profile.
Gambero
Alessandra
A
Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, 12916-900 Bragança Paulista, SP, Brazil. alessandragambero@saofrancisco.edu.br
Becker
Tagliane Liza
TL
Zago
Andréa Silva
AS
de Oliveira
Andréa Fermino
AF
Pedrazzoli
José
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D015232:Dinoprostone / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced*; D013929:Thromboxane B2 / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013929:Thromboxane B2; D015232:Dinoprostone