Antidepressants use in children and adolescents and the risk of suicide.
OBJECTIVE
Antidepressants use in paediatric patients has been linked with risk of suicidal behaviours. The aim of this paper, therefore, is to examine whether all antidepressants are associated with such risk.


METHODS
All 22 paediatric short-term placebo-controlled trials of SSRIs and NSRIs that were submitted to European registration authorities by pharmaceutical companies were identified and examined for events related to suicidality, which were defined as suicide, suicide attempts or suicidal thoughts. Random effect meta-analysis was used to combine the information from all trials.


RESULTS
No completed suicides were reported. However, for each compound there was at least one study with an increased risk for events related to suicidality in the active compound group. The overall OR for these events in the depression studies was 1.67 (95% CI: 1.05-2.65) and for anxiety 1.33 (95% CI: 0.33-5.35).


CONCLUSIONS
Caution is called for in the use of all SSRIs and NSRIs in the paediatric population. Furthermore, in the absence of contradictory information, caution in the use of other antidepressants in this population should be exercised as well (e.g. tricyclic antidepressants).
Wohlfarth
Tamar D
TD
Medicenes Evaluation Board of the Netherlands, The Hague. t.wohlfarth@cbg-meb.nl
van Zwieten
Barbara J
BJ
Lekkerkerker
Frits J
FJ
Gispen-de Wied
Christine C
CC
Ruis
Jerry R
JR
Elferink
Andre J A
AJ
Storosum
Jitschak G
JG
D000293:Adolescent; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D012306:Risk; D013405:Suicide / Q000706:statistics & numerical data*
D000928:Antidepressive Agents