title: Rats treated with oleoyl-oestrone maintain glucidic homeostasis: comparisons with a pair-fed model.
abstract: To determine whether or not the weight (and fat) loss induced by oleoyl-oestrone treatment results only as a consequence of decreased food intake, we compared treated animals with a pair-fed model. To this end, Wistar female rats received daily oral gavages of 10 mumol/kg per d oleoyl-oestrone in sunflower oil, or vehicle alone for 10 or 20 d. A second group of rats received the gavage of sunflower oil and the same amount of food ingested as the oleoyl-oestrone-treated animals (pair-fed group). Rats treated with oleoyl-oestrone maintained glucidic metabolism homeostasis despite a marked decrease in adipose tissue weight (P<0.001). Pair-fed rats exhibited a different pattern, comparable to short-term starvation, with greatly decreased glycogen stores (P<0.0001). The most significant effects were detected in the 10 d period groups. Oleoyl-oestrone affected the activity of the ponderostat system not only by decreasing appetite but also by modifying energy partition: treated animals maintained their glucose and energy homeostasis despite decreased food intake and the massive depletion of lipid stores.
authors.affiliation: Department de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal, 645, 08028 Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Salas
authors.forename: Montserrat
authors.initials: M
authors.lastname: Esteve
authors.forename: M
authors.initials: M
authors.lastname: Mar Grasa
authors.forename: Xavier
authors.initials: X
authors.lastname: Remesar
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D052242:Adiponectin / Q000097:blood; D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D004435:Eating / Q000502:physiology; D004970:Estrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D009929:Organ Size; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000502:physiology
chemical_list: D052242:Adiponectin; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D007328:Insulin; D020738:Leptin; D009829:Oleic Acids; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D004970:Estrone; C108709:oleoyl-estrone; D002784:Cholesterol; D020155:3-Hydroxybutyric Acid