The M235T polymorphism of the angiotensinogen gene in women with polycystic ovary syndrome.
To explore the relationship between variation in AGT M235T gene and the development of the polycystic ovary syndrome (PCOS) and its sequelae, in the present study we evaluated AGT polymorphism M235T in women with PCOS and in a control group. Moreover, to detect any relationship between AGT M235T variation and intermediate and quantitative traits relevant to the pathogenesis of cardiovascular disease and PCOS, we looked for genotype-dependent differences within the subjects with PCOS.
Zulian
Elisa
E
Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy.
Sartorato
Paola
P
Schiavi
Francesca
F
Moghetti
Paolo
P
Castello
Roberto
R
Mantero
Franco
F
Opocher
Giuseppe
G
Scaroni
Carla
C
D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution / Q000235:genetics; D000808:Angiotensinogen / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D013912:Threonine / Q000235:genetics
D000808:Angiotensinogen; D013912:Threonine; D008715:Methionine