title: Antibiotic prescription for community-acquired pneumonia in the intensive care unit: impact of adherence to Infectious Diseases Society of America guidelines on survival.
abstract: BACKGROUND
  The purpose of our study was to analyze prognostic factors associated with mortality for patients with severe community-acquired pneumonia (CAP).
  
  
  METHODS
  We conducted a prospective multicenter study including all patients with CAP admitted to the intensive care unit during a 15-month period in 33 Spanish hospitals. Admission data and data on the evolution of the disease were recorded. Multivariate analysis was performed using the SPSS statistical package (SPSS).
  
  
  RESULTS
  A total of 529 patients with severe CAP were enrolled; the mean age (+/-SD) was 59.9+/-16.1 years, and the mean Acute Physiology and Chronic Health Evaluation (APACHE) II score (+/-SD) was 18.9+/-7.4. Overall mortality among patients in the intensive case unit was 27.9% (148 patients). The rate of adherence to Infectious Diseases Society of America (IDSA) guidelines was 57.8%. Significantly higher mortality was documented among patients with nonadherence to treatment (33.2% vs. 24.2%). Multivariate analysis identified age (odds ratio [OR], 1.7), APACHE II score (OR, 4.1), nonadherence to IDSA guidelines (OR, 1.6), and immunocompromise (OR, 1.9) as the variables present at admission to the intensive care unit that were independently associated with death in the intensive care unit. In 15 (75%) of 20 cases of Pseudomonas aeruginosa infection, the antimicrobial treatment at admission was inadequate (including 8 of 15 cases involving patients with adherence to IDSA guidelines). Chronic obstructive pulmonary disease (OR, 17.9), malignancy (OR, 11.0), previous antibiotic exposure (OR, 6.2), and radiographic findings demonstrating rapid spread of disease (OR, 3.9) were associated with P. aeruginosa pneumonia.
  
  
  CONCLUSIONS
  Better adherence to IDSA guidelines would help to improve survival among patients with severe CAP. Pseudomonas coverage should be considered for patients with chronic obstructive pulmonary disease, malignancy, or recent antibiotic exposure.
authors.affiliation: Intensive Care Dept., Joan XXIII University Hospital, Tarragona, Spain. mbodi@hjxxiii.scs.es
authors.forename: M
authors.initials: M
authors.lastname: Bodí
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Solé-Violán
authors.forename: M C
authors.initials: MC
authors.lastname: Gilavert
authors.forename: J
authors.initials: J
authors.lastname: Garnacho
authors.forename: J
authors.initials: J
authors.lastname: Blanquer
authors.forename: J
authors.initials: J
authors.lastname: Jimenez
authors.forename: M V
authors.initials: MV
authors.lastname: de la Torre
authors.forename: J M
authors.initials: JM
authors.lastname: Sirvent
authors.forename: J
authors.initials: J
authors.lastname: Almirall
authors.forename: A
authors.initials: A
authors.lastname: Doblas
authors.forename: J R
authors.initials: JR
authors.lastname: Badía
authors.forename: F
authors.initials: F
authors.lastname: García
authors.forename: A
authors.initials: A
authors.lastname: Mendia
authors.forename: R
authors.initials: R
authors.lastname: Jordá
authors.forename: F
authors.initials: F
authors.lastname: Bobillo
authors.forename: J
authors.initials: J
authors.lastname: Vallés
authors.forename: M J
authors.initials: MJ
authors.lastname: Broch
authors.forename: N
authors.initials: N
authors.lastname: Carrasco
authors.forename: M A
authors.initials: MA
authors.lastname: Herranz
authors.forename: J
authors.initials: J
authors.lastname: Rello
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000401:mortality; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D005260:Female; D019983:Guideline Adherence / Q000706:statistics & numerical data*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000401:mortality*; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents