Lymphoplasmacytic lymphoma with IgA paraproteinemia mimicking Waldenstrom's Macroglobulinemia.
Central to the diagnosis of Waldenstrom's Macroglobulinemia is the demonstration of bone marrow infiltration by lymphoplasmacytic lymphoma with Ig M monoclonal gammopathy. We describe a patient who presented with a clinical and haematological picture, highly suggestive of Waldenstrom's Macroglobulinemia, but whose serum monoclonal immunoglobulin belonged to Ig A class. Ig A secreting lymphoplasmacytic lymphoma undoubtedly exist but are exceedingly uncommon and their relationship to Waldenstrom's Macroglobulinemia needs to be clarified.
Basu
Debdatta
D
Departments of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry. ddbasu@satyam.net.in
Pathak
Darshana
D
Shyambabu
C
C
Koner
Bidhan C
BC
Swaminathan
R P
RP
D003937:Diagnosis, Differential; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000175:diagnosis* / Q000276:immunology
D007070:Immunoglobulin A