title: Molecular imprinted ormosils for nafcillin recognition by room temperature phosphorescence optosensing.
abstract: Nafcillin imprinted sol-gels were used as specific binding materials for the room temperature phosphorescence (RTP) recognition of nafcillin using a flow injection system. Selective and reversible binding of the template to imprinted sol-gels could be observed by tailoring the hydrophobic/hydrophilic balance of the materials. Also, the possibility of minimizing non-specific interactions was evaluated by end-capping with trimethyl silyl groups. Control experiments were performed with non imprinted reference sol-gels. The recognition mechanism and the analytical potential of these materials for developing stable, selective and sensitive approaches for nafcillin recognition in real samples are outlined.
authors.affiliation: Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Av. Julián Clavería 8, 33006-Oviedo, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Guardia
authors.forename: R
authors.initials: R
authors.lastname: Badía
authors.forename: M E
authors.initials: ME
authors.lastname: Díaz-García
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation* / Q000379:methods; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D009254:Nafcillin / Q000032:analysis*; D055095:Optics and Photonics / Q000295:instrumentation; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
chemical_list: D009254:Nafcillin; D058428:Silica Gel; D012822:Silicon Dioxide