[Perforin and granzyme--the perfect material of biologic missile].
Perforin and granzyme are important effector molecules in cytolytic cells. They can induce apoptosis of tumor cells and infection cells. The research of biologic missile is noticed with the progress in therapy targeting to the disease. It is supposed that perforin and granzyme play an important role in biological missiles because of their biologic function and structure. A review on several aspects of these effector molecules is presented.
Dong
Hongmei
H
Department of Forensic Medicine, Medical College of Shantou University, Shantou 515041, China. hmdong@stu.edu.cn
Xu
Xiaohu
X
Yu
Xiaojun
X
D000818:Animals; D053804:Granzymes; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000627:therapeutic use*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D012697:Serine Endopeptidases / Q000276:immunology / Q000627:therapeutic use*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human