title: Preparation of nanosized drug particles by the coating of inorganic cores: naproxen and ketoprofen on alumina.
abstract: Nanosized alumina particles with modal diameters of 8 and 13 nm, respectively, were successfully coated by the adsorption of naproxen [(+)-6-methoxy-alpha-methyl-2-naphthalene acetic acid] and ketoprofen [alpha-methyl-3-(4-methylbenzoil) benzene acetic acid] in aqueous and ethanol solutions. The presence of the drugs at the alumina surface was confirmed by attenuated total reflection infrared spectroscopy and electrokinetic measurements, while their bound amounts were assessed by thermogravimetric analysis.
authors.affiliation: Center for Advanced Materials Processing, Clarkson University, Potsdam, New York, 13699-5814.
authors.forename: Laurent
authors.initials: L
authors.lastname: Joguet
authors.forename: Ivan
authors.initials: I
authors.lastname: Sondi
authors.forename: Egon
authors.initials: E
authors.lastname: Matijević
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry*; D007660:Ketoprofen / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009288:Naproxen / Q000737:chemistry*
chemical_list: D009288:Naproxen; D007660:Ketoprofen; D000537:Aluminum Oxide