title: Patients with MEN-1 are more insulin-resistant than their non-affected relatives.
abstract: BACKGROUND
  Given the clinical impression that patients with type 1 multiple endocrine neoplasia (MEN-1) frequently display abnormal glucose and lipoprotein concentrations, we compared affected subjects followed in our outpatient clinic with their non-affected relatives.
  
  
  METHODS
  The clinical histories of 35 members (19 affected) from six families with MEN-1 were reviewed. Total cholesterol, triglycerides, insulin, glucose, and insulin resistance (homeostasis model) were compared in affected and non-affected subjects.
  
  
  RESULTS
  The affected subjects displayed higher total cholesterol and triglycerides and more insulin resistance.
  
  
  CONCLUSIONS
  Patients with MEN-1 seem to be more insulin-resistant and to have a higher cardiovascular risk than their non-affected relatives. Three non-exclusive, biologically plausible hypotheses are proposed.
authors.affiliation: Department of Endocrinology and Metabolism, Hospital Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, S. Antoni M Claret 167, 08025 Barcelona, Spain. awgn@steno.dk
authors.forename: Ana M
authors.initials: AM
authors.lastname: Wägner
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Martín-Campos
authors.forename: Carmen
authors.initials: C
authors.lastname: Mayoral
authors.forename: Alberto
authors.initials: A
authors.lastname: de Leiva
authors.forename: Francisco
authors.initials: F
authors.lastname: Blanco-Vaca