Bemithyl potentiates the antioxidant effect of intermittent hypoxic training.
The rats were adapted to hypoxic hypoxia by intermittent training in a flow pressure chamber for 3 days. The course of bemithyl treatment (25 mg/kg intraperitoneally, 3 days) started immediately after the 1st day of training. Bemithyl potentiated the adaptive metabolic changes in rat brain induced by repeated hypoxic hypoxia, increased the individual resistance to hypoxia, and produced a long-lasting effect.
Zarubina
I V
IV
Department of Pharmacology, Russian Military Medical Academy, St. Petersburg.
Nurmanbetova
F N
FN
Shabanov
P D
PD
D000531:Altitude; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D000860:Hypoxia; D015227:Lipid Peroxidation; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D015656:Respiratory Mechanics; D013997:Time Factors
D000975:Antioxidants; D001562:Benzimidazoles; D005609:Free Radicals; C049825:bemethyl; D005978:Glutathione