Loss of 22q chromosome is related to glioma progression and loss of 10q.
Loss of heterozygosity (LOH) of chromosome 22q has been investigated in 160 gliomas. LOH at one or more microsatellite increased with increasing grade of the tumor (P < 0.01). LOH22q was more frequent in astrocytic tumors (37%) compared to mixed or oligodendroglial tumors (21%) (P = 0.02). LOH22q was correlated to 10q loss but not to 1p or 9p loss. Taken together, these data suggest that LOH22q is an alteration associated with malignant progression of gliomas.
Laigle-Donadey
Florence
F
Fédération de neurologie Mazarin, Groupe hospitalier Pitié-Salpétrière, 47-83 bd de l'Hôpital, 75013, Paris, France.
Crinière
Emmanuelle
E
Benouaich
Alexandra
A
Lesueur
Emmanuelle
E
Mokhtari
Karima
K
Hoang-Xuan
Khe
K
Sanson
Marc
M
D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002879:Chromosomes, Human, Pair 10; D002892:Chromosomes, Human, Pair 22; D018450:Disease Progression; D005819:Genetic Markers; D005910:Glioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016019:Survival Analysis
D005819:Genetic Markers