title: [Healing activity of methanolic extract of the barks of Spathodea campanulata Beauv (Bignoniaceae) in rat experimental burn model].
abstract: Spathodea campanulata Beauv. (Bignoniaceae) is widely distributed through Africa and found in particular in Cameroon and Senegal. It is used in traditional herbal medicine for the treatment of ulcers, filaria, gonorrhea, diarrhea and fever. S. campanulata was also known in Cameroon traditional medicine to have a healing activity in burn wounds. The aim of the present study was to assess the burn healing effectiveness of the methanolic extract of the barks of S. campanulata ointment (MEBSCO) in comparison to those of Centella asiatica and Peru's balm in experimental burn model in rats. Experimental burn was made in rat under chloral anaesthesia with electric iron (200 degrees C) on the right and left side of the medianus line. Topical applications of MEBSCO (2%, 10% and 49%) dose-dependently decreased the score damage of the burn site. Treatment with 10% and 49% of MEBSCO varied the score damage from 5 to 1 +/- 0.4 and 5 to 0.2 +/- 0.5 (p < 0.05, n = 5) respectively, at day 15 after experimental burn. As well as C. asiatica (1%) and Peru's balm (1%) ointments, MEBSCO (10% and 49%) induced a complete burn healing on the 19-20th post burn day. This study shows for the first time, the burn healing effectiveness of MEBSCO in experimental burn model. It also provides a rational use of the S. campanulata barks in traditional medicine to promote burn healing.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine et Pharmacie, Université Cheikh Anta Diop, BP 5005, Dakar, Sénégal. guatayoro_sy@yahoo.fr
authors.forename: G Y
authors.initials: GY
authors.lastname: Sy
authors.forename: R B
authors.initials: RB
authors.lastname: Nongonierma
authors.forename: P W C
authors.initials: PW
authors.lastname: Ngewou
authors.forename: D E
authors.initials: DE
authors.lastname: Mengata
authors.forename: A M
authors.initials: AM
authors.lastname: Dieye
authors.forename: A
authors.initials: A
authors.lastname: Cisse
authors.forename: B
authors.initials: B
authors.lastname: Faye
mesh_terms: D000818:Animals; D029402:Bignoniaceae; D002056:Burns / Q000628:therapy*; D002921:Cicatrix / Q000517:prevention & control; D004195:Disease Models, Animal; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts