Fine-needle aspiration cytology of epithelioid angiosarcoma: a diagnostic dilemma.
A 28-year-old woman with a 2-yr history of unilateral chronic leg swelling, initially thought to be secondary to deep vein thrombosis, later thought to be due to congenital venous malformation, eventually developed a pelvic mass, which was biopsied by fine-needle aspiration. On the basis of cytologic features on smears, high-grade sarcoma was reported. The patient underwent surgery to resect the pelvic mass, which showed anastomosing vascular channels arising from external iliac vein in histology. However, the tumor cells unexpectedly showed strong and diffuse immunohistochemical expression of cytokeratin and epithelial membrane antigen. The case was sent for expert consultation, and the expert's opinion was epithelioid angiosarcoma. The expert's diagnosis was confirmed 2 yr later by local recurrence. The clinical presentation, cytology, histology, and immunohistochemistry of the current case and 15 other cases of epithelioid angiosarcoma found in the cytology literature are summarized. This case illustrates that morphology with clinicopathologic correlation tends to be a better guide than available special techniques.
Gagner
Jean-Pierre
JP
Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.
Yim
Joon H
JH
Yang
Grace C H
GC
D000328:Adult; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007084:Iliac Vein / Q000000981:diagnostic imaging / Q000473:pathology*; D007150:Immunohistochemistry; D011859:Radiography; D019043:Vascular Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D020246:Venous Thrombosis / Q000000981:diagnostic imaging