title: [Lavasept as an alternative to PVP-iodine as a preoperative antiseptic in ophthalmic surgery. Randomized, controlled, prospective double-blind trial].
abstract: BACKGROUND
  To reduce the risk of endophthalmitis PVP-iodine is typically used preoperatively. Since iodine is contraindicated in patients with a specific allergic history or severe thyroid disorder we studied the effect of Lavasept, which contains Polyhexanid as an antiseptic alternative.
  
  
  METHODS
  In a randomized controlled double-blind trial 3 drops of 0.2% Lavasept, 1.25% PVP-iodine or Ringer's solution were applied preoperatively to 67 patients, which have had a minimum of 5 colony forming units (cfu's) in the conjunctival swap. The effectiveness and tolerability were measured.
  
  
  RESULTS
  After application of Lavasept or PVP-iodine, the number of cfu was statistically significantly reduced. Lavasept reduced the number of bacterial colonies significantly better than PVP-iodine (p=0.05). All test solutions were equally well tolerated.
  
  
  CONCLUSIONS
  The use af Lavasept is safe, well tolerated and reduces the microbiological contamination of the conjunctival fornix effectively. lt provides a more effective reduction of the cfu's than PVP-iodine 1.25% and this effect tends to be prolonged. Lavasept is a good alternative option in ophthalmology for preoperative antisepsis.
authors.affiliation: Klinik für Augenheilkunde, Campus Lübeck des Universitätsklinikums Schleswig-Holstein, Lübeck. hansmann@t-online.de
authors.forename: F
authors.initials: F
authors.lastname: Hansmann
authors.forename: A
authors.initials: A
authors.lastname: Kramer
authors.forename: H
authors.initials: H
authors.lastname: Ohgke
authors.forename: H
authors.initials: H
authors.lastname: Strobel
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Geerling
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D001645:Biguanides / Q000008:administration & dosage; D004311:Double-Blind Method; D015818:Eye Infections, Bacterial / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects*; D011206:Povidone-Iodine / Q000008:administration & dosage*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D001645:Biguanides; D011206:Povidone-Iodine