title: Cancer recurrence after total laryngectomy: treatment options, survival, and complications.
abstract: BACKGROUND
  A follow-up schedule to detect asymptomatic cancer recurrence is offered to all patients with laryngeal cancer. In this study, the therapeutic options, prognosis, and morbidity of patients with total laryngectomy, who were found to have cancer recurrence during this follow-up schedule were determined.
  
  
  METHODS
  Patients who had undergone a total laryngectomy between January 1, 1990, and January 1, 2000, and had cancer recurrence were included. Data from this group were analyzed retrospectively.
  
  
  RESULTS
  The prognosis was poor after the development of cancer recurrence. Curative therapy could only be offered to 27.5% of these patients. Only 5% of the patients were disease free at the end of the study period. Many patients with cancer recurrence needed interventions. A large proportion of them had complications.
  
  
  CONCLUSIONS
  The follow-up schedule offered to patients after total laryngectomy should put greater emphasis on care than on early detection of cancer recurrence.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Savitri C
authors.initials: SC
authors.lastname: Ritoe
authors.forename: Heidi
authors.initials: H
authors.lastname: Bergman
authors.forename: Paul F M
authors.initials: PF
authors.lastname: Krabbe
authors.forename: Johannes H A M
authors.initials: JH
authors.lastname: Kaanders
authors.forename: Frank J A
authors.initials: FJ
authors.lastname: van den Hoogen
authors.forename: André L M
authors.initials: AL
authors.lastname: Verbeek
authors.forename: Henri A M
authors.initials: HA
authors.lastname: Marres
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D016879:Salvage Therapy; D015996:Survival Rate; D013997:Time Factors