Autofluorescence imaging of choroidal neovascularization due to age-related macular degeneration.
OBJECTIVE
To describe the autofluorescence (AF) characteristics of choroidal neovascularization (CNV) in patients with age-related macular degeneration.


METHODS
Autofluorescence images of 65 consecutive eyes with CNV at various stages of evolution were analyzed. Twenty images were of recent-onset CNV (group 1), 8 were of eyes 1 to 6 months after CNV diagnosis (group 2), and 37 were late-stage CNV (group 3). Autofluorescence images from groups 1 and 2 were compared with fundus fluorescein angiographic images.


RESULTS
Group 1 showed areas of hyperfluorescence on fundus fluorescein angiography corresponding to areas of normal AF in 16 of 20 cases, with adjacent areas of increased AF in 13 cases. The main areas of abnormal AF were larger than the main areas of abnormal fluorescence on fundus fluorescein angiography in 18 of the 20 cases. Groups 2 and 3 showed areas of decreased AF corresponding to areas of previous leakage on fundus fluorescein angiography (in group 2) or atrophy.


CONCLUSIONS
Preserved AF in group 1 indicates viable retinal pigment epithelium initially, which has implications for visual prognosis. Decreased AF in groups 2 and 3 indicates loss of retinal pigment epithelium and photoreceptors. Autofluorescence imaging may increase our understanding of CNV in age-related macular degeneration.
Dandekar
Samantha S
SS
Moorfields Eye Hospital and Institute of Ophthalmology, London, England. sam@hitbits.co.uk
Jenkins
Sharon A
SA
Peto
Tunde
T
Scholl
Hendrik P N
HP
Sehmi
Kulwant S
KS
Fitzke
Fred W
FW
Bird
Alan C
AC
Webster
Andrew R
AR
D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000209:etiology; D003952:Diagnostic Imaging; D005260:Female; D005451:Fluorescein Angiography; D005453:Fluorescence; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology