title: Adaptive Aerosol Delivery (AAD) technology.
abstract: Jet nebulisers have, since the 1920s, been used for delivery of inhaled drugs for the treatment of asthma, chronic-obstructive pulmonary disease and pulmonary infections. During the last two decades, recognition of the shortcomings of conventional nebulisers has led to the development of new "intelligent" nebulisers such as the Adaptive Aerosol Delivery (AAD), Profile Therapeutics, a Respironics company) systems. Diseases of the airways have traditionally been logical candidates for treatment with inhaled drugs. The introduction of the "intelligent" nebulisers has, however, broadened the possibilities for inhaled treatment to include drugs targeted for systemic diseases. These nebulisers offer the possibility to deliver more precise doses of drug, maximise lung deposition, enhance adherence to treatment and compliance with the device through feedback to the patient, and last but not least, offer the possibility to reduce nebulisation times.
authors.affiliation: Profile Therapeutics, Bognor Regis, West Sussex, PO22 9SL, UK.
authors.forename: J
authors.initials: J
authors.lastname: Denyer
authors.forename: K
authors.initials: K
authors.lastname: Nikander
authors.forename: N J
authors.initials: NJ
authors.lastname: Smith
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy* / Q000503:physiopathology; D009330:Nebulizers and Vaporizers; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013678:Technology, Pharmaceutical
chemical_list: D000336:Aerosols; D004364:Pharmaceutical Preparations