title: Endocarditis caused by Propionibacterium acnes: an easily ignored pathogen.
abstract: Propionibacterium acnes, which usually considered as a contaminant, has been found to be an emerging pathogen in human diseases. We describe a case of prosthetic valve related endocarditis caused by P. acnes. Sequencing of the genetic coding of 16S ribosomal RNA was used to identify the pathogen and random amplified polymorphic DNA patterns further confirmed the persistent bacteraemia, which help to determine the diagnosis.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei 100, Taiwan, ROC.
authors.forename: Sung-Ching
authors.initials: SC
authors.lastname: Pan
authors.forename: Jann-Tay
authors.initials: JT
authors.lastname: Wang
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
authors.forename: Shan-Chwen
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002440:Cefoxitin / Q000008:administration & dosage; D002981:Clindamycin / Q000008:administration & dosage; D021821:Communicable Diseases, Emerging / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010400:Penicillin G / Q000008:administration & dosage; D016133:Polymerase Chain Reaction / Q000379:methods; D011425:Propionibacterium acnes / Q000235:genetics / Q000302:isolation & purification*; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry; D019105:Random Amplified Polymorphic DNA Technique / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S; D002981:Clindamycin; D002440:Cefoxitin; D010400:Penicillin G