Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells.
Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.
Wu
Hsing-Ju
HJ
The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia.
Seib
Kate L
KL
Edwards
Jennifer L
JL
Apicella
Michael A
MA
McEwan
Alastair G
AG
Jennings
Michael P
MP
D001400:Azurin / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D002584:Cervix Uteri / Q000382:microbiology*; D003300:Copper / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004847:Epithelial Cells / Q000382:microbiology; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D018384:Oxidative Stress
D001400:Azurin; D003300:Copper; D006861:Hydrogen Peroxide