The genetics of hearing and balance in zebrafish.
The zebrafish is an excellent model system for studying the molecular basis of inner ear development and function. The eggs develop ex utero and the ear is transparent for the first few weeks of life. Forward genetic screens and antisense technology have helped to elucidate the signaling pathways and molecules required for inner ear development and function. This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish.
Nicolson
Teresa
T
Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA. nicolson@ohsu.edu
D000818:Animals; D007758:Ear, Inner / Q000033:anatomy & histology / Q000196:embryology / Q000378:metabolism; D006198:Hair Cells, Auditory / Q000502:physiology; D006309:Hearing / Q000235:genetics* / Q000502:physiology*; D040542:Mechanotransduction, Cellular; D004856:Postural Balance; D015027:Zebrafish / Q000033:anatomy & histology / Q000235:genetics* / Q000502:physiology*