title: Using impedance cardiography to assess left ventricular systolic function via postural change in patients with heart failure.
abstract: For the diagnosis and management of heart failure, it would be useful to have a simple point-of-care test for assessing ventricular function that could be performed by a nurse. An impedance cardiography (ICG) parameter called systolic amplitude (SA) can serve as an indicator of left ventricular systolic function (LVSF). This study tested the hypothesis that patients with normal LVSF should have a significant increase in SA in response to an increase in end-diastolic volume caused by postural change from sitting upright to supine, while patients with depressed LVSF associated with heart failure should have a minimal increase or a decrease in SA from upright to supine. ICG data were obtained in 12 patients without heart disease and with normal LVSF and 18 patients with clinically diagnosed heart failure. Consistent with the hypothesis, patients with normal LVSF had a significant increase in SA from upright to supine, whereas heart failure patients had a minimal increase or a decrease in SA from upright to supine. This ICG procedure may be useful for monitoring the trend of patient response to titration of beta blockers and other medications. ICG potentially could be used to detect worsening LVSF and provide a means of measurement for adjusting treatment.
authors.affiliation: Dermed Diagnostics Inc., 2-S 558 White Birch Lane, Wheaton, IL 60187, USA. ademarzo.dermed@att.net
authors.forename: Arthur P
authors.initials: AP
authors.lastname: DeMarzo
authors.forename: James E
authors.initials: JE
authors.lastname: Calvin
authors.forename: Russell F
authors.initials: RF
authors.lastname: Kelly
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Stamos
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002307:Cardiography, Impedance / Q000379:methods* / Q000451:nursing / Q000592:standards; D016022:Case-Control Studies; D015400:Clinical Nursing Research; D018450:Disease Progression; D016903:Drug Monitoring; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009730:Nursing Assessment; D019095:Point-of-Care Systems; D011187:Posture; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted; D013318:Stroke Volume; D013599:Systole; D016277:Ventricular Function, Left
chemical_list: D000319:Adrenergic beta-Antagonists