Low-density lipoprotein receptor-related protein 5 variant A1330V is a determinant of blood pressure in Japanese males.
We examined the influence of the A1330V variant in the low-density lipoprotein receptor-related protein 5 gene on blood pressure in a large cohort of Japanese workers. This study used analysis of covariance in a multivariate general linear model to adjust for other potential factors such as age, body mass index, blood chemistry and lifestyle. The target subjects were 1440 males and 1169 females selected from 3834 male and 2591 female workers in a single company. Hypertension was defined as systolic blood pressure >or=140 mm Hg and/or diastolic blood pressure >or=90 mm Hg or the use of antihypertensive medications. Genotype distributions for A1330V in hypertensive males (AA=139(54.5%), AV=101(39.6%), VV=15(5.9%)) and females (AA=48(63.2%), AV=24(31.6%), VV=4(5.3%)) were not significantly different from normotensive males (AA=594(50.1%), AV=488(41.2%), VV=103(8.7%)) and females (AA=568(52.0%), AV=441(40.3%), VV=84(7.7%)). Allele distributions were not significantly different in either sex. In males, analysis of covariance showed that the VV genotype was associated with a 2.5 mm Hg lower diastolic blood pressure and a 2.3 mm Hg lower mean blood pressure than the AA genotype. This study indicates that the 1330V allele is an independent factor for lower diastolic and mean blood pressure in Japanese males.
Suwazono
Yasushi
Y
Department of Occupational and Environmental Medicine (A2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba 260-8670, Japan. suwa@faculty.chiba-u.jp
Kobayashi
Etsuko
E
Uetani
Mirei
M
Miura
Katsuyuki
K
Morikawa
Yuko
Y
Ishizaki
Masao
M
Kido
Teruhiko
T
Nakagawa
Hideaki
H
Nogawa
Koji
K
D000328:Adult; D000375:Aging / Q000502:physiology; D000483:Alleles; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000235:genetics*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D008019:Life Style; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D008297:Male; D015999:Multivariate Analysis
D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5