title: [Low ability of blood lymphocytes to produce interferon-gamma in patients with idiopathic prolapse of mitral valve].
abstract: OBJECTIVE
  To examine lymphocyte ability to synthetize interferon-gamma in patients with mitral prolapse (MP).
  
  
  METHODS
  The diagnosis of MP was made in 75 patients at echocardiography. ECG monitoring was made and the study of the ability of blood lymphocytes to produce IFN-gamma (If-g).
  
  
  RESULTS
  The ability to produce If-g was diminished. This phenomenon is associated with chronic inflammation, autonomic disregulation of cardiac activity, depends on gender.
  
  
  CONCLUSIONS
  Cytokine modulates metabolism of connective tissue in MP so If-g may participate in MP pathogenesis. Therefore, If-g and/or its inductors may prevent some MP-related complications due to its deficiency.
authors.forename: I D
authors.initials: ID
authors.lastname: Surkina
authors.forename: K G
authors.initials: KG
authors.lastname: Gurevich
authors.forename: O O
authors.initials: OO
authors.lastname: Mel'nik
authors.forename: E V
authors.initials: EV
authors.lastname: Akatova
authors.forename: O B
authors.initials: OB
authors.lastname: Stepura
authors.forename: L S
authors.initials: LS
authors.lastname: Pak
authors.forename: A I
authors.initials: AI
authors.lastname: Martynov
mesh_terms: D000328:Adult; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008945:Mitral Valve Prolapse / Q000276:immunology* / Q000378:metabolism
chemical_list: D007371:Interferon-gamma