Tungtungmadic acid, a novel antioxidant, from Salicornia herbacea.
Tungtungmadic acid (3-caffeoyl-4-dihydrocaffeoyl quinic acid) is a new chlorogenic acid derivative that was isolated from the Salicornia herbacea. The structure of tungtungmadic acid was determined using chemical and spectral analysis. The antioxidant activity of tungtungmadic acid was evaluated using various antioxidant assays, including free radical scavenging, lipid peroxidation and hydroxyl radical-induced DNA strand breaks assays. Tungtungmadic acid (IC50 = 5.1 microM and 9.3 microM) was found to have higher antioxidant activity in the DPPH scavenging assay as well as in the iron-induced liver microsomal lipid peroxidation system. In addition, the tungtungmadic acid was also effective in protecting the plasmid DNA against strand breakage induced by hydroxyl radicals.
Chung
Young Chul
YC
Division of Food Science, Chinju International University, Chinju, Korea. fnjung@hanmail.net
Chun
Hyo Kon
HK
Yang
Jae Young
JY
Kim
Ji Young
JY
Han
Eun Hee
EH
Kho
Yung Hee
YH
Jeong
Hye Gwang
HG
D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002726:Chlorogenic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000975:Antioxidants; D010936:Plant Extracts; D002726:Chlorogenic Acid