Gray matter decrease in patients with chronic tension type headache.
Using MRI and voxel-based morphometry, the authors investigated 20 patients with chronic tension type headache (CTTH) and 20 patients with medication-overuse headache and compared them to 40 controls with no headache history. Only patients with CTTH demonstrated a significant gray matter decrease in regions known to be involved in pain processing. The finding implies that the alterations are specific to CTTH rather than a response to chronic head pain or chronification per se.
Schmidt-Wilcke
T
T
Department of Neurology, University of Regensburg, Regensburg, Germany.
Leinisch
E
E
Straube
A
A
Kämpfe
N
N
Draganski
B
B
Diener
H C
HC
Bogdahn
U
U
May
A
A
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001284:Atrophy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D051271:Headache Disorders, Secondary / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D018781:Tension-Type Headache / Q000175:diagnosis* / Q000503:physiopathology; D014363:Tryptamines / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines