Chronotherapeutic approach to design a thermoresponsive membrane for transdermal drug delivery.
In this review, the concepts of chronobiology, circadian rhythm, chronopharmacology, homeostasis and chronotherapy are taken into account to approach the optimal drug therapy, in which the timing of drug administration plays an important role. Based on these considerations, our laboratory has developed a thermo-responsive membrane by entrapping a single or binary liquid crystal to achieve an on-off switching drug delivery for transdermal application via the externally repeated cycle of temperature change, which may simulate the dosing time of therapeutic needs for human body.
Lin
Shan-Yang
SY
Biopharmaceutical Laboratory, Department of Medical Research & Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China. sylin@vghtpe.gov.tw
D000279:Administration, Cutaneous; D001831:Body Temperature / Q000502:physiology*; D019454:Chronotherapy / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
D004364:Pharmaceutical Preparations