P53 alteration in oral tongue cancer is not significantly associated with age at diagnosis or tobacco exposure.
OBJECTIVE
The tumor suppressor gene P53 is mutated in almost half of head and neck cancers. The current work assessed the prognostic significance of P53 alteration in patients with squamous cell carcinoma of the oral tongue treated with a curative intent, its association with age at diagnosis (using 45 years as a cut point), and risk exposure as defined by tobacco and/or alcohol consumption.


METHODS
P53 alteration was determined immunohistochemically in 45 patients with tongue cancer treated with a curative intent.


RESULTS
P53 alteration occurred in 20 of 45 tumors (44%) and was more common among younger patients (58% versus 36% for younger versus older patients, respectively) and those lacking tobacco/alcohol exposure (53% versus 40% for "no-risk" and "risk" groups, respectively), but the differences were not statistically significant. With a median follow-up of 56 months, 5-year progression-free survival rates were 48% and 66% in patients with and without P53 detection, respectively (P = 0.22).


CONCLUSIONS
Despite a trend of a younger age at diagnosis in P53-altered tumors, results did not reach statistically significant differences. A trend of a worse clinical outcome with P53 alteration was noted.
Siegelmann-Danieli
Nava
N
Geisinger Medical Center, Danville, Pennsylvania, USA. nsd@seagal.us
Ben-Izhack
Ofer
O
Hanlon
Alexandra
A
Ridge
John A
JA
Stein
Moshe E
ME
Khandelwal
Vivek
V
Langer
Corey J
CJ
D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000175:diagnosis / Q000209:etiology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000209:etiology; D009154:Mutation; D011237:Predictive Value of Tests; D011379:Prognosis; D012907:Smoking / Q000009:adverse effects; D014029:Tobacco Use Disorder / Q000150:complications; D014062:Tongue Neoplasms / Q000175:diagnosis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53