title: The clinical course of ulcerative colitis after orthotopic liver transplantation for primary sclerosing cholangitis: further appraisal of immunosuppression post transplantation.
abstract: OBJECTIVE
  The course of ulcerative colitis (UC) following orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC) is unclear. We documented the nationwide experience of the course of UC, before and after OLT for PSC.
  
  
  RESULTS
  A total of 470 liver transplants were performed for 413 patients between 1992 and 2003, in the Scottish Liver Transplantation Unit, UK. Twenty-six patients had co-existing UC/PSC. Of these, data from 20 patients were studied over a median period of 11.9 years before OLT and 4.4 years after OLT; of the others, four patients required colectomy prior to OLT, one died within 7 days of transplant, and one developed UC after transplant. A significantly higher relapse rate (number of relapses/year of follow-up) was seen after OLT (median 1.0 versus 0.3; interquartile range, 0.10-1.42 and 0.01-0.40, respectively; P = 0.007). The corticosteroids requirement (number of courses/year of follow-up) after OLT was also significantly higher (0.40 versus 0.10; interquartile range, 0.51-1.13 and 0.05-0.12, respectively; P = 0.003). Twenty per cent of patients (4/20) became corticosteroid dependent after OLT. Thirty-five per cent of patients (7/20) underwent colectomy after OLT: three for severe disease and four for neoplasia/dysplasia. Five patients (19%) developed neoplasia following OLT.
  
  
  CONCLUSIONS
  Despite immunosuppression, UC follows a more aggressive clinical course after OLT and is associated with a high rate of neoplasia.
authors.affiliation: Scottish Liver Transplantation Unit, New Royal Infirmary, Little France, Edinburgh, UK.
authors.forename: Gwo-Tzer
authors.initials: GT
authors.lastname: Ho
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: Seddon
authors.forename: George
authors.initials: G
authors.lastname: Therapondos
authors.forename: Jack
authors.initials: J
authors.lastname: Satsangi
authors.forename: Peter C
authors.initials: PC
authors.lastname: Hayes
mesh_terms: D000328:Adult; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000601:surgery*; D003082:Colectomy / Q000706:statistics & numerical data; D003093:Colitis, Ulcerative / Q000150:complications / Q000628:therapy; D004334:Drug Administration Schedule; D004812:Epidemiologic Methods; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology; D011182:Postoperative Care / Q000379:methods; D012008:Recurrence
chemical_list: D005938:Glucocorticoids