title: Type 1 diabetes mellitus: etiology, presentation, and management.
abstract: This article reviews our current understanding of the etiology, presentation, and management of type 1 diabetes. The discussion includes a review of the natural history of diabetes, the complex relationship between genetic and environmental risk for type 1 diabetes, and current methods for prediction of type 1 diabetes. The article also reviews the current management of children who have new-onset type 1 diabetes, age-appropriate management goals, and diabetes complications. Finally, the article discusses the future of diabetes screening programs and the progress toward the ultimate goal of curing type 1 diabetes.
authors.affiliation: Division of Pediatric Endocrinology, University of Florida College of Medicine, PO Box 100296, Gainesville, FL 32610, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Haller
authors.forename: Mark A
authors.initials: MA
authors.lastname: Atkinson
authors.forename: Desmond
authors.initials: D
authors.lastname: Schatz
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002648:Child; D048909:Diabetes Complications / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D016883:Diabetic Ketoacidosis / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology / Q000628:therapy; D007328:Insulin / Q000031:analogs & derivatives / Q000627:therapeutic use; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D044623:Nutrition Therapy
chemical_list: D001323:Autoantibodies; D001786:Blood Glucose; D007328:Insulin; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine