title: Comparative studies on the camptothecin content from Nothapodytes foetida and Ophiorrhiza species.
abstract: Camptothecin is an anticancer quinoline alkaloid effective against colon cancer. It acts by inhibition of the enzyme DNA topoisomerase I. A comparative study of camptothecin from the indigenous plants namely Nothapodytes foetida, Ophiorrhiza mungos and Ophiorrhiza rugosa indicated highest yields of camptothecin and 9-methoxy camptothecin in N. foetida. The other two plants O. mungos and O. rugosa contained low levels of alkaloids.
authors.affiliation: Plant Biotechnology and Secondary Products Section, Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. groja@magnum.barc.ernet.in
authors.forename: G
authors.initials: G
authors.lastname: Roja
mesh_terms: D002166:Camptothecin / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D019684:Magnoliopsida / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002166:Camptothecin