Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease.
To study the potential diagnostic value of abnormally phosphorylated tau protein in Creutzfeldt-Jakob disease (CJD) compared to Alzheimer's disease (AD), we determined levels of tau phosphorylated at threonine 231 (p-tau231) and of total tau (t-tau) in cerebrospinal fluid (CSF) of CJD patients, AD patients, and healthy controls (HC). CJD patients showed excessively high t-tau levels but relatively low p-tau(231) concentrations compared to the AD group. t-tau alone yielded the best diagnostic accuracy to differentiate between CJD and AD patients, when compared to p-tau231 and the p-tau231/t-tau ratio (97, 78, and 95% correctly allocated cases, respectively). Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD.
Buerger
Katharina
K
Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany. katharina.buerger@med.uni-muenchen.de
Otto
Markus
M
Teipel
Stefan J
SJ
Zinkowski
Raymond
R
Blennow
Kaj
K
DeBernardis
John
J
Kerkman
Daniel
D
Schröder
Johannes
J
Schönknecht
Peter
P
Cepek
Lukas
L
McCulloch
Cheryl
C
Möller
Hans-Jürgen
HJ
Wiltfang
Jens
J
Kretzschmar
Hans
H
Hampel
Harald
H
D017677:Age Distribution; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D015995:Prevalence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D013223:Statistics as Topic; D013912:Threonine / Q000378:metabolism*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D016875:tau Proteins; D013912:Threonine