title: Trafficking mechanism of water channel aquaporin-2.
abstract: Targeted positioning of the water channel AQP2 (aquaporin-2) strictly regulates body water homoeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. In addition to the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signalling cascades can also induce this sorting. Recently, AQP2-binding proteins which could regulate this trafficking have been discovered; SPA-1 (signal-induced proliferation-associated gene-1), a GAP (GTPase-activating protein) for Rap1, and the cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanisms of AQP2.
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Noda
authors.forename: Sei
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D051399:Aquaporin 2 / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003599:Cytoskeleton / Q000737:chemistry / Q000378:metabolism; D004705:Endocytosis; D020690:GTPase-Activating Proteins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000502:physiology; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D021381:Protein Transport; D015398:Signal Transduction; D014667:Vasopressins / Q000502:physiology
chemical_list: D000199:Actins; D051399:Aquaporin 2; D002966:Clathrin; D020690:GTPase-Activating Proteins; D009687:Nuclear Proteins; C490403:SIPA1 protein, human; D014667:Vasopressins; D017868:Cyclic AMP-Dependent Protein Kinases