title: Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III).
abstract: Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and (1)H and (13)C NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.
authors.affiliation: Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.
authors.forename: David E
authors.initials: DE
authors.lastname: Green
authors.forename: Cara L
authors.initials: CL
authors.lastname: Ferreira
authors.forename: Robert V
authors.initials: RV
authors.lastname: Stick
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Adam
authors.forename: Chris
authors.initials: C
authors.lastname: Orvig
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D005708:Gallium / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013057:Spectrum Analysis
chemical_list: D002241:Carbohydrates; D008024:Ligands; D009942:Organometallic Compounds; D011728:Pyridones; D019275:Radiopharmaceuticals; D007204:Indium; D005708:Gallium