title: Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina.
abstract: BACKGROUND
  This study was performed to assess the relationship between oxidized low-density lipoprotein (OxLDL) and restenosis. OxLDL induces up-regulation of inflammatory genes and cytokines and recruits monocytes to the vessel wall. Elevated levels of monocytes post-percutaneous coronary intervention (PCI) are associated with in-stent restenosis.
  
  
  RESULTS
  One hundred forty-one patients with stable angina pectoris had serial blood samples drawn before PCI (68% balloon only, 32% stent), immediately post-PCI and at 6 and 24 hours, 3 days, 1 week, and 1, 3, and 6 months. Plasma levels of OxLDL-E06, a measure of oxidized phospholipid (OxPL) content on apoB-100 detected by antibody E06 (OxPL/apoB), autoantibodies to malondialdehyde-LDL and copper-oxidized LDL, and apoB-immune complexes were measured in all samples. Quantitative and qualitative coronary angiography was performed with 94% angiographic follow-up. Restenosis was defined as >50% diameter stenosis (%DS). The overall angiographic restenosis rate was 32% (39% in balloon group, 16% in stent group). OxPL/apoB levels rose significantly and OxLDL autoantibody titers decreased immediately post-PCI in patients both with and without restenosis, but there were no significant differences among groups. There was also no relationship of any OxLDL marker to lesion length, %DS, or minimal lumen diameter. No differences were noted in stent versus balloon-treated patients.
  
  
  CONCLUSIONS
  Serial measurement of a comprehensive panel of circulating OxLDL markers after uncomplicated PCI for stable angina does not predict restenosis.
authors.affiliation: Ann and Roy Foss Interventional Research Program, Terrence Donnelly Heart Centre, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Amit
authors.initials: A
authors.lastname: Segev
authors.forename: Bradley H
authors.initials: BH
authors.lastname: Strauss
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Witztum
authors.forename: Herbert K
authors.initials: HK
authors.lastname: Lau
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tsimikas
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood* / Q000000981:diagnostic imaging* / Q000628:therapy; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D008077:Lipoproteins, LDL