title: Do recipients of kidneys from donors treated with streptokinase develop anti-streptokinase antibodies?
abstract: Streptokinase is used for preflush for non-heart-beating donors (NHBDs) in our center. The aim of this study was to evaluate whether the use of thrombolytic streptokinase results in the production of anti-streptokinase antibodies in the recipients after renal transplantation. Recipient sera taken prior to and at 1 and 6 months posttransplant were tested for the presence of antibodies to streptokinase using an enzyme-linked immunosorbent assay assay. No differences were detected between a group of 18 recipients who had kidneys from thrombolytic-treated NHBDs and a further group of 18 who received NHBD kidneys without such treatment.
authors.affiliation: Department of Renal and Liver Transplant, The Freeman Hospital, High Heaton, Newcastle Upon Tyne NE7 7DN, United Kingdom. D.Talbot@ncl.ac.uk
authors.forename: H
authors.initials: H
authors.lastname: Mi
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: M A
authors.initials: MA
authors.lastname: Gok
authors.forename: J
authors.initials: J
authors.lastname: Asher
authors.forename: B K
authors.initials: BK
authors.lastname: Shenton
authors.forename: S
authors.initials: S
authors.lastname: Stamp
authors.forename: V
authors.initials: V
authors.lastname: Carter
authors.forename: J
authors.initials: J
authors.lastname: Del Rio Martin
authors.forename: N A
authors.initials: NA
authors.lastname: Soomro
authors.forename: B C
authors.initials: BC
authors.lastname: Jaques
authors.forename: D M
authors.initials: DM
authors.lastname: Manas
authors.forename: D
authors.initials: D
authors.lastname: Talbot
mesh_terms: D000906:Antibodies / Q000097:blood*; D000917:Antibody Formation; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006323:Heart Arrest; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012189:Retrospective Studies; D013300:Streptokinase / Q000276:immunology* / Q000627:therapeutic use*; D014019:Tissue Donors
chemical_list: D000906:Antibodies; D005343:Fibrinolytic Agents; D013300:Streptokinase