title: Clinical observations of the effect of antidiuretic hormone on nocturia in elderly men.
abstract: OBJECTIVE
  To evaluate the effect of desmopressin on nocturia, based on patients' subjective scoring of nocturia, as desmopressin is widely used to treat nocturnal enuresis and nocturnal polyuria.
  
  
  METHODS
  We investigated a specific subgroup of 28 men with benign prostate obstruction and nocturia who were treated with desmopressin. Patients with nocturnal polyuria were excluded. All the patients were refractory to treatment with antimuscarinics or anticholinergics, e.g. oxybutynin, tolterodine, and propantheline bromide. We assessed the effect of desmopressin using a quantitative nocturia score and analysed its synergistic effect with alpha-blockers.
  
  
  RESULTS
  The mean frequency of nocturia was 6.1 before desmopressin and most (86%) patients had an improvement in nocturia within 1-12 weeks of treatment with desmopressin. There was a 43% reduction in nocturia after using desmopressin (P < 0.001). The correlation coefficient between the number of nocturnal voids and the reduction in nocturia after treatment with desmopressin was 0.756, indicating that the more severe the nocturia, the more effective was desmopressin.
  
  
  CONCLUSIONS
  Desmopressin is effective for refractory nocturia in elderly men with no nocturnal polyuria, and has limited side-effects.
authors.affiliation: Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi, Taiwan, ROC.
authors.forename: Dong-Ru
authors.initials: DR
authors.lastname: Ho
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Lin
authors.forename: Ching-Fang
authors.initials: CF
authors.lastname: Wu
authors.forename: Jia-Jen
authors.initials: JJ
authors.lastname: Shee
authors.forename: Yun-Ching
authors.initials: YC
authors.lastname: Huang
authors.forename: Chih-Shou
authors.initials: CS
authors.lastname: Chen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D050034:Antidiuretic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications; D012044:Regression Analysis; D016896:Treatment Outcome; D014555:Urination Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin