title: Eosinophilic pleurisy induced by dantrolene.
abstract: A 70-year-old male developed eosinophilic pleurisy fifteen years after dantrolene sodium had been started for his spastic paraplegia due to spinocerebellar degeneration. Drug lymphocyte stimulation test (DLST) for dantrolene was positive. After discontinuance of dantrolene, pleural effusion gradually decreased and inflammatory reaction improved. During two-year observation, we have found no relapse of pleurisy without special medication. We present this case and compare this case with other 10 reported cases.
authors.affiliation: Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara City, Kanagawa 259-1193, Japan. urantets@is.icc.u-tokai.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Urano
authors.forename: Mai
authors.initials: M
authors.lastname: Nishiumi
authors.forename: Sakurako
authors.initials: S
authors.lastname: Tajiri
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Toshimori
authors.initials: T
authors.lastname: Tanigaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kita
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tokuoka
authors.forename: Masao
authors.initials: M
authors.lastname: Nagayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000368:Aged; D003620:Dantrolene / Q000009:adverse effects* / Q000627:therapeutic use; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects* / Q000627:therapeutic use; D010264:Paraplegia / Q000188:drug therapy / Q000209:etiology; D010998:Pleurisy / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D013902:Radiography, Thoracic; D013132:Spinocerebellar Degenerations / Q000150:complications / Q000188:drug therapy
chemical_list: D009125:Muscle Relaxants, Central; D003620:Dantrolene