title: Substituted indanylacetic acids as PPAR-alpha-gamma activators.
abstract: A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
authors.affiliation: Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. derek.lowe@bayer.com
authors.forename: Derek B
authors.initials: DB
authors.lastname: Lowe
authors.forename: Neil
authors.initials: N
authors.lastname: Bifulco
authors.forename: William H
authors.initials: WH
authors.lastname: Bullock
authors.forename: Thomas
authors.initials: T
authors.lastname: Claus
authors.forename: Philip
authors.initials: P
authors.lastname: Coish
authors.forename: Miao
authors.initials: M
authors.lastname: Dai
authors.forename: Fernando E
authors.initials: FE
authors.lastname: Dela Cruz
authors.forename: David
authors.initials: D
authors.lastname: Dickson
authors.forename: Dongping
authors.initials: D
authors.lastname: Fan
authors.forename: Helana
authors.initials: H
authors.lastname: Hoover-Litty
authors.forename: Tindy
authors.initials: T
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Gretchen
authors.initials: G
authors.lastname: Mannelly
authors.forename: Mary-Katherine
authors.initials: MK
authors.lastname: Monahan
authors.forename: Ingo
authors.initials: I
authors.lastname: Muegge
authors.forename: Stephen
authors.initials: S
authors.lastname: O'Connor
authors.forename: Mareli
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Tatiana
authors.initials: T
authors.lastname: Shelekhin
authors.forename: Andreas
authors.initials: A
authors.lastname: Stolle
authors.forename: Laurel
authors.initials: L
authors.lastname: Sweet
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Yamin
authors.initials: Y
authors.lastname: Wang
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Zhang
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Mingbao
authors.initials: M
authors.lastname: Zhang
authors.forename: Kake
authors.initials: K
authors.lastname: Zhao
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Manami
authors.initials: M
authors.lastname: Tsutsumi
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D008024:Ligands; D051379:Mice; D008817:Mice, Mutant Strains; D008820:Mice, Obese; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D000085:Acetates; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008024:Ligands; D010080:Oxazoles; D047493:PPAR alpha; D047495:PPAR gamma; D014280:Triglycerides