title: Efficacy of tigecycline in complicated skin and skin structure infections and complicated intra-abdominal infections.
abstract: Treatment of complicated skin and skin structure infection (cSSSI) and complicated intra-abdominal infection (cIAI) currently present a therapeutic challenge because many of the pathogens involved are becoming resistant to standard antimicrobial therapy. Tigecycline is a novel glycylcycline that exhibits expanded broad-spectrum antibacterial activity against certain resistant pathogens. Results from randomised Phase III studies comparing the clinical and microbiological efficacy of tigecycline with combination antimicrobial therapy for the treatment of cSSSI and cIAI are encouraging. Tigecycline has the potential to be used as monotherapy for the treatment of cSSSI and cIAI.
authors.affiliation: Department of Microbiology, Leeds Teaching Hospitals & University of Leeds, UK. Mark.Wilcox@leedsth.nhs.uk
authors.forename: M H
authors.initials: MH
authors.lastname: Wilcox
mesh_terms: D018784:Abdominal Abscess / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy*; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline