title: Myxomatous stromal changes and necrosis of bone marrow--a retrospective study of 3 years.
abstract: Myxomatous stromal changes and bone marrow necrosis (BMN) are uncommon histologic findings. These changes have been found in various conditions like disseminated carcinomatosis, postchemotherapy cases, chronic infections, infiltrative disorders of the marrow etc. The present study is a retrospective study of 3 years (Jan, 1999 to Dec. 2001) from Deptt. Of Hematology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh (India). During this period, 3740 bone marrow samples were examined. Myxomatous stromal changes and bone marrow necrosis were noted in 0.43% (16/3740) and 0.45% (17/3740) samples respectively. In addition to common causes of myxomatous stromal changes and bone marrow necrosis as described in the literature, this study highlights the association of these conditions with some of the rarer entities like hyperoxalosis, leishmaniasis, parvovirus induced marrow aplasia and cryptococcal infection. There is paucity of such associations in the literature.
authors.affiliation: Department of Hematology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh.
authors.forename: Nalini
authors.initials: N
authors.lastname: Gupta
authors.forename: Vijay
authors.initials: V
authors.lastname: Kumar
authors.forename: Neelam
authors.initials: N
authors.lastname: Varma
authors.forename: Gurjeevan
authors.initials: G
authors.lastname: Garewal
authors.forename: Reena
authors.initials: R
authors.lastname: Das
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.forename: Sumitra
authors.initials: S
authors.lastname: Dash
mesh_terms: D001854:Bone Marrow Cells / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000473:pathology; D009234:Myxomatosis, Infectious / Q000473:pathology*; D009336:Necrosis; D012189:Retrospective Studies; D017154:Stromal Cells / Q000473:pathology*