Effects of colestimide and/or Bofu-tsusho-san on plasma and liver lipids in mice fed a high-fat diet.
Hypercholesterolemia is known to enhance the risk of coronary heart disease and fatty liver. Colestimide is an anion-exchange resin, which is not absorbed in the small intestine, decreases the intestinal reabsorption of bile acids synthesized from cholesterol in the liver and consequently increases bile acid excretion into the feces. Bofu-tsusho-san, a traditional Japanese herbal remedy, contains 18 components and has long been used as an anti-obesity agent. In the present study, we investigated the effects of colestimide and/or Bohu-tsusho-san in young male mice fed a high-fat diet. The high-fat diet supplemented with both colestimide and Bofu-tsusho-san markedly reduced the plasma levels of lipids, the liver weight and number of fatty droplets in the liver cytoplasm, and the body growth, compared with animals fed a high-fat diet alone. Neither medicine affected the blood biochemistry. Thus, the hypocholesterolemic action of colestimide, sometimes bringing light flatulence, which is improved by simultaneous administration of Bofu-tsusho-san, which activates the thermogenesis of brown adipose tissue, is suggested to reduce body mass and liver lipids, lowering the plasma levels of lipids.
Sakamoto
Shinobu
S
Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. motoend@tmd.ac.jp
Takeshita
Shingo
S
Sassa
Shuji
S
Suzuki
Satoe
S
Ishikawa
Yuko
Y
Kudo
Hideki
H
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000837:Anion Exchange Resins / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000008:administration & dosage*; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004811:Epichlorohydrin / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000517:prevention & control; D007093:Imidazoles / Q000494:pharmacology*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010743:Phospholipids / Q000097:blood; D012117:Resins, Synthetic / Q000494:pharmacology*; D022722:Thermogenesis / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D000837:Anion Exchange Resins; D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D007093:Imidazoles; D008055:Lipids; D010726:Phosphodiesterase Inhibitors; D010743:Phospholipids; D012117:Resins, Synthetic; D014280:Triglycerides; C098310:bofu-tsusho-san; C417427:colestimide; D004811:Epichlorohydrin; D002784:Cholesterol