New agents with antimycobacterial activity.
In this paper, we report that a series of structurally simple a-halogenoacetamides show potent and excellent antimycobacterial activities against drug-sensitive Mycobacterium tuberculosis H(37)Rv and drug-resistant M. avium.
Marco-Contelles
José
J
Laboratorio de Radicales Libres, Madrid, Spain. iqoc21@iqog.csic.es
Gómez-Sánchez
Elena
E
D000081:Acetamides / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D006846:Hydrocarbons, Halogenated / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009162:Mycobacterium avium / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000081:Acetamides; D000900:Anti-Bacterial Agents; D006846:Hydrocarbons, Halogenated