Patients with MEN-1 are more insulin-resistant than their non-affected relatives.
BACKGROUND
Given the clinical impression that patients with type 1 multiple endocrine neoplasia (MEN-1) frequently display abnormal glucose and lipoprotein concentrations, we compared affected subjects followed in our outpatient clinic with their non-affected relatives.


METHODS
The clinical histories of 35 members (19 affected) from six families with MEN-1 were reviewed. Total cholesterol, triglycerides, insulin, glucose, and insulin resistance (homeostasis model) were compared in affected and non-affected subjects.


RESULTS
The affected subjects displayed higher total cholesterol and triglycerides and more insulin resistance.


CONCLUSIONS
Patients with MEN-1 seem to be more insulin-resistant and to have a higher cardiovascular risk than their non-affected relatives. Three non-exclusive, biologically plausible hypotheses are proposed.
Wägner
Ana M
AM
Department of Endocrinology and Metabolism, Hospital Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, S. Antoni M Claret 167, 08025 Barcelona, Spain. awgn@steno.dk
Martín-Campos
Jesus M
JM
Mayoral
Carmen
C
de Leiva
Alberto
A
Blanco-Vaca
Francisco
F