title: Near-infrared fiber optic spectroscopy as a novel diagnostic tool for the detection of pancreatic cancer.
abstract: We have investigated the application of near-infrared (NIR) fiber-optic spectroscopy for the diagnosis of pancreatic cancer. Cluster analysis of the Fourier transformed near-infrared (FTNIR) fiber-optic spectra of surgically resected pancreatic tumor tissues allowed discrimination of tumor from normal tissue with high sensitivity and specificity. The sensitivity of the method using spectral information of the CH stretching first overtone region (5951-5608 cm(-1)) was 83.3% with a specificity of 83.3%. Based on the CH stretching second overtone region (8605-7938 cm(-1)) we could achieve a sensitivity of 88.9% and specificity of 72.2%. These findings suggest that NIR spectroscopy offers the potential for minimally invasive in-vivo diagnosis of pancreatic cancer.
authors.affiliation: Mannheim University of Applied Sciences, Institute for Instrumental Analysis and Bioanalysis, Mannheim, Germany.
authors.forename: Venkata R
authors.initials: VR
authors.lastname: Kondepati
authors.forename: Johann
authors.initials: J
authors.lastname: Zimmermann
authors.forename: Michael
authors.initials: M
authors.lastname: Keese
authors.forename: Joerg
authors.initials: J
authors.lastname: Sturm
authors.forename: Bernd C
authors.initials: BC
authors.lastname: Manegold
authors.forename: Juergen
authors.initials: J
authors.lastname: Backhaus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001185:Artificial Intelligence; D014408:Biomarkers, Tumor / Q000032:analysis*; D016000:Cluster Analysis; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D008297:Male; D008875:Middle Aged; D055100:Optical Fibers; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor