title: Herpes simplex virus type 2 recurrent meningitis (Mollaret's meningitis): a consideration for the recurrent pathogenesis.
abstract: We report a 44-year-old Japanese woman with herpes simplex virus (HSV) type 2 recurrent meningitis (Mollaret's meningitis). The diagnosis was confirmed by nested polymerase chain reaction in her cerebrospinal fluid, but the patient's conventional HSV antibodies by complement fixation, neutralizing test or enzyme immunoassay showed low titres with low lymphoproliferative response. Several similar cases are discussed. Although the reason for the recurrent pathogenesis is uncertain, our report suggests that the low immune response including immune evasion may be involved in the pathogenesis of HSV type 2 recurrent meningitis. For this patient, long-term suppressive and patient-initiated therapies were conducted to prevent the recurrence of meningitis.
authors.affiliation: First Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, Japan.
authors.forename: Rumi
authors.initials: R
authors.lastname: Sato
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Ayabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shoji
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichiyama
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Saito
authors.forename: Ryo
authors.initials: R
authors.lastname: Hondo
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Eizuru
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage*; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000008:administration & dosage*; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D006558:Herpes Genitalis / Q000150:complications; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D008582:Meningitis, Aseptic / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D016133:Polymerase Chain Reaction; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir