title: Evaluation of bowel distention and bowel wall appearance by using neutral oral contrast agent for multi-detector row CT.
abstract: OBJECTIVE
  To prospectively evaluate the performance of an orally administered 0.1% barium suspension, Volumen, as a bowel-marking agent for multi-detector row computed tomography (CT).
  
  
  METHODS
  This HIPAA-compliant study was approved by the Institutional Review Board and conformed to the institutional standards for research funded by a commercial sponsor. A total of 60 patients (33 women, 27 men; average age, 58.2 years) who were referred for multi-detector row CT of the pancreas were randomized into two groups. Prior to examination, group 1 consumed 1200 mL of Volumen over a 30-minute period and group 2 consumed 1200 mL of a solution containing three parts water and one part methylcellulose over a 30-minute period. Results were independently reviewed by two radiologists who were unaware of the contrast agent used. The degree of distention and the visualization of mural detail were qualitatively scored on a five-point scale. Differences were evaluated by using the Mann-Whitney test at a confidence level of 95%.
  
  
  RESULTS
  There was significantly better distention in the stomach (P = .013), duodenum (P = .006), jejunum (P = .029), and ileum (P = .014) [corrected] in group 1 compared with group 2. Significant distention was also evident by comparing the products of the widest cross-sectional diameters in duodenum (P = .143), jejunum (P < .001), and ileum (P < .001). Group 1 also demonstrated significantly better visualization of mural features in the duodenum (P = .003), jejunum (P = .024), and ileum (P = .01) and a trend toward better visualization of mural features in the stomach (P = .092).
  
  
  CONCLUSIONS
  Oral administration of Volumen provided excellent distention and excellent visualization of mural features in the gastrointestinal tract.
authors.affiliation: Department of Radiology, New York University School of Medicine, 550 First Ave, Rm IRM 232, New York, NY 10016, USA. alec.megibow@nyumc.org
authors.forename: Alec J
authors.initials: AJ
authors.lastname: Megibow
authors.forename: James S
authors.initials: JS
authors.lastname: Babb
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Hecht
authors.forename: Jennie J
authors.initials: JJ
authors.lastname: Cho
authors.forename: Carmela
authors.initials: C
authors.lastname: Houston
authors.forename: Michael M
authors.initials: MM
authors.lastname: Boruch
authors.forename: Archie B
authors.initials: AB
authors.lastname: Williams
mesh_terms: D000284:Administration, Oral; D001466:Barium Sulfate / Q000008:administration & dosage; D003287:Contrast Media / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate