title: Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock.
abstract: Evidence is increasing that oxygen debt and its metabolic correlates are important quantifiers of the severity of hemorrhagic and post-traumatic shock and and may serve as useful guides in the treatment of these conditions. The aim of this review is to demonstrate the similarity between experimental oxygen debt in animals and human hemorrhage/post-traumatic conditions, and to examine metabolic oxygen debt correlates, namely base deficit and lactate, as indices of shock severity and adequacy of volume resuscitation. Relevant studies in the medical literature were identified using Medline and Cochrane Library searches. Findings in both experimental animals (dog/pig) and humans suggest that oxygen debt or its metabolic correlates may be more useful quantifiers of hemorrhagic shock than estimates of blood loss, volume replacement, blood pressure, or heart rate. This is evidenced by the oxygen debt/probability of death curves for the animals, and by the consistency of lethal dose (LD)25,50 points for base deficit across all three species. Quantifying human post-traumatic shock based on base deficit and adjusting for Glasgow Coma Scale score, prothrombin time, Injury Severity Score and age is demonstrated to be superior to anatomic injury severity alone or in combination with Trauma and Injury Severity Score. The data examined in this review indicate that estimates of oxygen debt and its metabolic correlates should be included in studies of experimental shock and in the management of patients suffering from hemorrhagic shock.
authors.affiliation: Department of Trauma/Orthopedic Surgery, University of Witten/Herdecke at the Hospital Merheim, Cologne, Germany. dieter.rixen@uni-wh.de
authors.forename: Dieter
authors.initials: D
authors.lastname: Rixen
authors.forename: John H
authors.initials: JH
authors.lastname: Siegel
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000097:blood*; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D020896:Hypovolemia / Q000378:metabolism / Q000628:therapy; D000860:Hypoxia / Q000097:blood* / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood*; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000378:metabolism; D012774:Shock, Traumatic / Q000097:blood* / Q000378:metabolism; D013552:Swine; D015599:Trauma Severity Indices
chemical_list: D019344:Lactic Acid