title: Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables.
abstract: Propolis is a resinous substance produced by honeybees that possesses many biological activities, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory, among others. The purpose of the present study was to investigate the biochemical profile of propolis-treated rats to observe whether propolis might lead to side effects after administration. Three different treatments were analyzed: (1) rats were treated with different concentrations of propolis (1, 3 and 6 mg/kg/day) during 30 days; (2) rats were treated with 1 mg/kg/day of ethanolic or water extracts of propolis (EEP, WEP) during 30 days; (3) rats were treated with 1 mg/kg/day of ethanolic extract of propolis during 90 and 150 days. Our results demonstrated no alterations in the seric levels of cholesterol, HDL-cholesterol, total lipids, triglycerides and in the specific activity of aminotransferases (AST) and lactic dehydrogenase (LDH) of propolis-treated groups when compared to controls. On the basis of our findings, since propolis does not induce any significant change in seric parameters, it is claimed that long-term administration of propolis might not have any cardiac injury.
authors.affiliation: Department of Chemistry and Biochemistry, Biosciences Institute, UNESP, 18600-000 Botucatu, SP, Brazil. femani@ibb.unesp.br
authors.forename: F
authors.initials: F
authors.lastname: Mani
authors.forename: H C R
authors.initials: HC
authors.lastname: Damasceno
authors.forename: E L B
authors.initials: EL
authors.lastname: Novelli
authors.forename: E A M
authors.initials: EA
authors.lastname: Martins
authors.forename: J M
authors.initials: JM
authors.lastname: Sforcin
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D008297:Male; D011429:Propolis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D011429:Propolis