title: Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis.
abstract: Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage-gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage-gated potassium channel antibody-associated limbic encephalitis onset. In three patients, immunosuppression resulted in resolution of RBD in parallel with remission of the limbic syndrome. RBD persisted in two patients with partial resolution of the limbic syndrome. Our findings suggest that RBD is frequent in the setting of voltage-gated potassium channel antibody-associated limbic encephalitis and can be related to autoimmune-mediated mechanisms. In addition, these observations suggest that impairment of the limbic system may play a role in the pathogenesis of RBD.
authors.affiliation: Neurology Service, Hospital Clínic and Institut d'Investigació Biomèdiques August Pi i Sunyer, C/Villaroel 170, 08036 Barcelona, Spain. airanzo@clinic.ub.es
authors.forename: Alex
authors.initials: A
authors.lastname: Iranzo
authors.forename: Francesc
authors.initials: F
authors.lastname: Graus
authors.forename: Linda
authors.initials: L
authors.lastname: Clover
authors.forename: Jaume
authors.initials: J
authors.lastname: Morera
authors.forename: Jordi
authors.initials: J
authors.lastname: Bruna
authors.forename: Carlos
authors.initials: C
authors.lastname: Vilar
authors.forename: José Enrique
authors.initials: JE
authors.lastname: Martínez-Rodriguez
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
authors.forename: Joan
authors.initials: J
authors.lastname: Santamaría
mesh_terms: D000368:Aged; D000906:Antibodies / Q000276:immunology*; D004569:Electroencephalography; D004576:Electromyography; D006801:Humans; D020363:Limbic Encephalitis / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D020187:REM Sleep Behavior Disorder / Q000209:etiology / Q000276:immunology / Q000503:physiopathology
chemical_list: D000906:Antibodies; D024642:Potassium Channels, Voltage-Gated