[Protective effects of yanggan lidan granules on carbon tetrachloride-induced liver damage in mice].
OBJECTIVE
To observe the protective effects of Yanggan Lidan Granules (YGLDG) on carbon tetrachloride (CCl(4))-induced liver damage in mice and to find out its mechanism.


METHODS
A model of chronic liver damage was established in mice by intraperitoneal injection of CCl(4). After three weeks, those model mice were treated with low-, medium-, high-dose YGLDG, Danning Tablets and bifendate respectively for four weeks. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected.


RESULTS
YGLDG could significantly reduce the levels of serum ALT and AST in model mice, and the content of MDA was obviously decreased while the content of SOD was increased in liver tissue.


CONCLUSIONS
The therapeutic effect of YGLDG on mice with CCl(4)-induced liver damage is to relieve the seriousness of liver damage, and its mechanism may relate to reducing peroxidation activity in liver tissue.
You
Sheng-Fu
SF
Center of Scientific Research, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zheng
Pei-Yong
PY
Ji
Guang
G
Wei
Hua-Feng
HF
Zhao
Jie
J
Zhu
Pei-Ting
PT
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D008517:Phytotherapy; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000097:blood
D004365:Drugs, Chinese Herbal; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase