A carbohydrate-based approach for the total synthesis of 1,3-polyol/alpha-pyrone antifungal natural products.
[Chemical reaction: see text] An elimination and stereoselective hydrogenation of alpha-D-glucoheptonic-gamma-lactone derivative has been applied to prepare a differentially protected anti,anti-1,3,5-triol system, the utility of which has been extended for the total synthesis of anti-fungal 1,3-polyol/alpha-pyrone natural products.
Ramana
C V
CV
National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411 008, India. vr.chepuri@ncl.res.in
Srinivas
Burgula
B
Puranik
Vedavati G
VG
Gurjar
Mukund K
MK
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates; D003460:Crystallization; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011108:Polymers; D011753:Pyrones
D000935:Antifungal Agents; D002241:Carbohydrates; D007202:Indicators and Reagents; D011108:Polymers; D011753:Pyrones; C024617:polyol