Ras-related signaling pathways in valve development: ebb and flow.
Congenital heart defects affect approximately 1 in every 100 live births, and deficits in the formation of the mitral, tricuspid, and outflow tract valves account for 20-25% of all cardiac malformations. Mutations in genes that affect Ras signaling have been identified in individuals with congenital valve disease associated with Noonan syndrome and neurofibromatosis type 1. Dissection of Ras-related signaling pathways during valvulogenesis provides seminal insight into cellular and molecular mechanisms that contribute to congenital heart disease.
Yutzey
Katherine E
KE
Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Research Foundation, Ohio, USA.
Colbert
Melissa
M
Robbins
Jeffrey
J
D000818:Animals; D047109:Fetal Development / Q000502:physiology; D006330:Heart Defects, Congenital / Q000235:genetics; D006351:Heart Valves / Q000196:embryology*; D006801:Humans; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D018631:ras Proteins / Q000378:metabolism*
D018631:ras Proteins