Past and future: porphyria and porphyrins.
Porphyria is a compelling disease--disrupted enzyme pathways, heightened sensitivities, and a fascinating history tied in with tales of Dracula. This review discusses the history, pathophysiology, classification, and treatment of porphyria. It further discusses the way in which research on the etiologies of the various porphyrias has led to the development of porphyrin-based photodynamic therapy, which shows great promise in targeted therapy for a variety of serious pathologies.
Norman
Robert A
RA
Department of Dermatology, Nova Southeastern University College of Osteopathic Medicine, Ft. Lauderdale, FL, USA. skindrrob@aol.com
D003937:Diagnosis, Differential; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D017119:Porphyria Cutanea Tarda / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000266:history*