Activation markers in Behçet's disease.
BACKGROUND
One of the main problems in Behçet's disease is the lack of an original laboratory marker that can reflect clinical activity. In this study, laboratory parameters that could be used as indicators of active disease are investigated.


METHODS
The study included a total of 40 patients with Behçet's disease, 25 of whom were active and 15 inactive, who applied to Firat University, Firat Medical Center Dermatology, Rheumatology, Physiotherapy, and Ophthalmology outpatient clinics and a control group composed of 30 healthy volunteers. Serum neopterin, C-reactive protein (CRP), and sedimentation rate (ESR) levels were determined in all patients and healthy controls.


RESULTS
Serum neopterin, CRP, and ESR levels in active Behçet's disease patients were significantly higher than those in both the inactive group and healthy controls (p<0.001).


CONCLUSIONS
It was contemplated that together with serum CRP and ESR, neopterin could be a useful laboratory parameter in patients in whom disease activation could not be determined.
Coskun
Basak
B
Department of Dermatology, Firat University, Faculty of Medicine, TR 23119 Elazig, Turkey. basakkc@hotmail.com
Saral
Yunus
Y
Gödekmerdan
Ahmet
A
Erden
Ilker
I
Coskun
Naci
N
D000328:Adult; D001528:Behcet Syndrome / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D019798:Neopterin / Q000097:blood*; D011237:Predictive Value of Tests
D015415:Biomarkers; D019798:Neopterin; D002097:C-Reactive Protein