APOE epsilon2/epsilon4 polymorphism and cerebral microbleeds on gradient-echo MRI.
The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.69 to 2.11) for nonlobar CMBs. This suggests that the pathogenesis of CMBs may differ depending on their location.
Kim
M
M
Seoul National University Hospital, Seoul, Korea.
Bae
H J
HJ
Lee
J
J
Kang
L
L
Lee
S
S
Kim
S
S
Lee
J E
JE
Lee
K M
KM
Yoon
B W
BW
Kwon
O
O
Koo
J S
JS
Kim
B K
BK
D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D015984:Causality; D016657:Cerebral Amyloid Angiopathy / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012737:Sex Factors; D012907:Smoking
D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E