Reversible weight gain and prolactin levels--long-term follow-up in childhood.
In adult patients weight gain is a frequent complaint of hyperprolactinaemia and it has been associated with a high prevalence of obesity. Normalization of prolactin (PRL) levels result in weight loss. The nature of this link is poorly defined. In this report we describe a 14 year-old female with primary amenorrhea and persistent progressive weight gain. The patient's height, weight and BMI were 152 cm, 70 kg, and 30.3 kg/m2, respectively. Basal hormonal investigation showed normal free thyroxin, TSH, IGF-I, cortisol and ACTH values. Serum PRL level was very high (16,278 mIU/l; normal range 63-426 mIU/l). Magnetic resonance imaging scan showed the presence of a pituitary microadenoma. Treatment with the non-selective dopamine agonist pergolide caused a significant reduction of serum PRL concentration with a remarkable decrease of body weight. During follow-up, repeat MRI scan revealed disappearance of the microadenoma. The reduction of the daily dose of pergolide was associated with an increase of serum PRL with significant weight gain. A further reduction of body weight was subsequently observed with an increase of pergolide dosage. Serum PRL measurement may be useful as part of the endocrine work-up of obese children with a history of unexplained recent weight gain, especially if associated with pituitary-gonadal axis dysfunction. The relationship between PRL secretion and weight change needs to be examined in prospective larger studies.
Galluzzi
F
F
Paediatric Endocrinology Unit, Department of Paediatrics, University of Florence, Florence, Italy. galluzzi@unifi.it
Salti
R
R
Stagi
S
S
La Cauza
F
F
Chiarelli
F
F
D000293:Adolescent; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D010479:Pergolide / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D015430:Weight Gain / Q000187:drug effects
D018491:Dopamine Agonists; D010479:Pergolide; D011388:Prolactin