[Linezolid, the first oxazolidinone antibiotic].
The spread of multiresistant Staphylococcus and Enterococcus strains required the development of new drugs. Linezolid is the first molecule of a new antibiotic family, oxazolidinones, with an original mechanism of action. In this general review, the authors first present its antibacterial activity, its pharmacokinetic properties, its therapeutic uses in serious Gram-positive infections, pneumonia, skin and soft tissue infections, and also in other indications. They then explain the rules for administration and tolerability.
Dutronc
H
H
Fédération de maladies infectieuses, groupe hospitalier Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. herve.dutronc@chu-bordeaux.fr
Bocquentin
F
F
Galpérine
T
T
Lafarie-Castet
S
S
Dupon
M
M
D000081:Acetamides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016983:Enterococcus / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011500:Protein Synthesis Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013210:Staphylococcus / Q000187:drug effects*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D011500:Protein Synthesis Inhibitors; D000069349:Linezolid