title: Modelling vaccination schedules for a cancer immunoprevention vaccine.
abstract: We present a systematic approach to search for an effective vaccination schedule using mathematical computerized models. Our study is based on our previous model that simulates the cancer vs immune system competition activated by tumor vaccine. This model accurately reproduces in-vivo experiments results on HER-2/neu mice treated with the immuno-prevention cancer vaccine (Triplex) for mammary carcinoma. In vivo experiments have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma. The full protection was conferred using chronic (prophylactic) vaccination protocol while therapeutic vaccination was less efficient. In the present paper we use the computer simulations to systematically search for a vaccination schedule which prevents solid tumor formation. The strategy we used for defining a successful vaccination schedule is to control the number of cancer cells with vaccination cycles. We found that, applying the vaccination scheme used in in-vivo experiments, the number of vaccine injections can be reduced roughly by 30%.
authors.affiliation: Department of Mathematics and Computer Science, University of Catania, Catania, Italy. motta@dmi.unict.it
authors.forename: Santo
authors.initials: S
authors.lastname: Motta
authors.forename: Filippo
authors.initials: F
authors.lastname: Castiglione
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Lollini
authors.forename: Francesco
authors.initials: F
authors.lastname: Pappalardo