title: Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics.
abstract: 1,5-Dideoxy-1,5-imino-D-glucitol, the corresponding D-manno and L-ido epimers as well as the powerful beta-glucosidase inhibitor isofagomine were N-alkylated with di-, tri-, as well as tetraethylene glycol derived straight chain spacer arms by a set of simple standard procedures. The terminal functional groups of the spacer arms, primary amines, were employed to introduce fluorescent dansyl moieties. Resulting derivatives showed glycosidase inhibitory activities comparable to those of the parent compounds'.
authors.affiliation: Glycogroup, Institut für Organische Chemie, Technische Universität Graz, Stremayrgasse 16, A-8010 Graz, Austria.
authors.forename: Inge
authors.initials: I
authors.lastname: Lundt
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Steiner
authors.forename: Arnold E
authors.initials: AE
authors.lastname: Stütz
authors.forename: Chris A
authors.initials: CA
authors.lastname: Tarling
authors.forename: Stefan
authors.initials: S
authors.lastname: Ully
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Withers
authors.forename: Tanja M
authors.initials: TM
authors.lastname: Wrodnigg
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D050112:Imino Pyranoses / Q000494:pharmacology; D050111:Imino Sugars / Q000737:chemistry* / Q000494:pharmacology; D007700:Kinetics; D010880:Piperidines / Q000494:pharmacology; D012231:Rhizobium / Q000201:enzymology; D013402:Sugar Alcohols / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D005456:Fluorescent Dyes; D050112:Imino Pyranoses; D050111:Imino Sugars; D010880:Piperidines; D013402:Sugar Alcohols; C098432:isofagomine; D006026:Glycoside Hydrolases