title: [Effects of short-term chemotherapy on the compliance of rabbit abdominal aorta].
abstract: OBJECTIVE
  To investigate the effect of short-term chemotherapy on the compliance of rabbit abdominal aorta, and understand the changes in the biomechanical properties of the blood vessels after chemotherapy.
  
  
  METHODS
  Fifteen rabbits were divided into 5 groups, 4 of which were subjected to injection with chemotherapeutic agents for 5 days to evaluate the compliance of the abdominal aorta at 2, 7, 14, and 21 days after the therapy with the other group without chemotherapy serving as the control.
  
  
  RESULTS
  The compliance of the abdominal aorta was obviously decreased after chemotherapy and reached the lowest level 14 days after short-term chemotherapy, suggesting that the drugs resulted in vascular injury enough to alter the biomechanical properties of the blood vessels.
  
  
  CONCLUSIONS
  Short-term chemotherapy can decrease the compliance of the blood vessels, which may deteriorate with time but such changes can be reversible.
authors.affiliation: Sixth Hospital of Shanghai Jiaotong University, Shanghai 200233, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Shen
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zuo
authors.forename: Jun-yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Jin-xing
authors.initials: JX
authors.lastname: Yang
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000494:pharmacology; D001012:Aorta, Abdominal / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology; D003187:Compliance / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D011817:Rabbits
chemical_list: D003520:Cyclophosphamide; D002945:Cisplatin