title: Increased granulocyte chemotactic protein-2 concentrations in peritoneal fluid of women with endometriosis.
abstract: BACKGROUND
  To evaluate the release of granulocyte chemotactic protein-2 (GCP-2) into peritoneal fluid in women with endometriosis, we measured its concentration with reference to the disease stage and the phase of the menstrual cycle.
  
  
  METHODS
  Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 64 women with endometriosis (n = 38) or cystadenomas (n = 26). GCP-2 concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Our findings indicated elevated concentrations of GCP-2 in peritoneal fluid from women with endometriosis during the proliferative phase, which were positively correlated with the stage of endometriosis.
  
  
  CONCLUSIONS
  Inflammation associated with endometriosis may be involved in the pathogenesis of the disease through increasing levels of peritoneal fluid GCP-2.
authors.affiliation: Department of Obstetrics & Gynecology, Nagoya City University Graduate School of Medicine, 1-Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan. og.n.suz@med.nagoya-cu.ac.jp
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzumori
authors.forename: Xaio Xi
authors.initials: XX
authors.lastname: Zhao
authors.forename: Kaoru
authors.initials: K
authors.lastname: Suzumori
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism; D016022:Case-Control Studies; D054427:Chemokine CXCL6; D019743:Chemokines, CXC / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006098:Granulocytes; D006801:Humans; D008597:Menstrual Cycle; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: C515503:CXCL6 protein, human; D054427:Chemokine CXCL6; D019743:Chemokines, CXC