title: Solid phase synthesis of pyridine-based derivatives from a 2-chloro-5-bromopyridine scaffold.
abstract: 2-Chloro-5-bromopyridine was immobilized on polystyrene via selective introduction of a traceless silicon linker at the C-4 position. A useful scaffold was thus obtained, as demonstrated by efficient and selective reactions with polar and transition organometallic reagents, opening a new access to pyridine-based libraries of synthons and chromophores.
authors.affiliation: Synthèse Organométallique et Réactivité, UMR 7565, Faculté des Sciences, Université Henri Poincaré, Boulevard des Aiguillettes, BP 239, 54506 Vandoeuvre-lès-Nancy, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pierrat
authors.forename: Philippe C
authors.initials: PC
authors.lastname: Gros
authors.forename: Yves
authors.initials: Y
authors.lastname: Fort