Evaluation of acrylate-based block copolymers prepared by atom transfer radical polymerization as matrices for paclitaxel delivery from coronary stents.
Acrylate-based block copolymers, synthesized by atom transfer radical polymerization (ATRP) processes, were evaluated as drug delivery matrices for the controlled release of paclitaxel from coronary stents. The polymers were multiblock copolymers consisting of poly(butyl acrylate) or poly(lauryl acrylate) soft blocks and hard blocks composed of poly(methyl methacrylate), poly(isobornyl acrylate), or poly(styrene) homo- or copolymers. Depending on the ratio of hard to soft blocks in the copolymers, coating formulations were produced that possessed variable elastomeric properties, resulting in stent coatings that maintained their integrity when assessed by scanning electron microscopy (SEM) imaging of overexpanded stents. In vitro paclitaxel release kinetics from coronary stents coated with these copolymers typically showed an early burst followed by sustained release behavior, which permitted the elution of the majority of the paclitaxel over a 10-day time period. It was determined that neither the nature of the polyacrylate (n-butyl or lauryl) nor that of the hard block appeared to affect the release kinetics of paclitaxel at a loading of 25% drug by weight, whereas some effects were observed at lower drug loading levels. Differential scanning calorimetry (DSC) analysis indicated that the paclitaxel was at least partially miscible with the poly(n-butyl acrylate) phase of those block copolymers. The copolymers were also evaluated for sterilization stability by exposing both the copolymer alone and copolymer/paclitaxel coated stents to e-beam radiation at doses of 1-3 times the nominal dose used for medical device sterilization (25 kGy). It was found that the copolymers containing blocks bearing quaternary carbons within the polymer backbone were less stable to the radiation and showed a decrease in molecular weight as determined by gel-permeation chromatography. Conversely, those without quaternary carbons showed no significant change in molecular weight when exposed to 3 times the standard radiation dose. There was no significant change in drug release profile from any of the acrylate-based copolymers after exposure to 75 kGy of e-beam radiation, and this was attributed to the inherent radiation stability of the poly(n-butyl acrylate) center block.
Richard
Robert E
RE
Corporate Research & Advanced Technology Development, Boston Scientific Corporation, Natick, Massachusetts 01760, USA.
Schwarz
Marlene
M
Ranade
Shrirang
S
Chan
A Ken
AK
Matyjaszewski
Krzysztof
K
Sumerlin
Brent
B
D000179:Acrylates / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002244:Carbon / Q000737:chemistry; D003327:Coronary Disease / Q000473:pathology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D008823:Micelles; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D009206:Myocardium / Q000473:pathology*; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry; D015607:Stents; D013997:Time Factors
D000179:Acrylates; D000972:Antineoplastic Agents, Phytogenic; D001672:Biocompatible Materials; D004337:Drug Carriers; D046911:Macromolecular Substances; D008823:Micelles; D011108:Polymers; D011092:Polyethylene Glycols; D002244:Carbon; D019904:Polymethyl Methacrylate; D017239:Paclitaxel; D000432:Methanol