title: Pre- and postinvasion defenses both contribute to nonhost resistance in Arabidopsis.
abstract: Nonhost resistance describes the immunity of an entire plant species against nonadapted pathogen species. We report that Arabidopsis PEN2 restricts pathogen entry of two ascomycete powdery mildew fungi that in nature colonize grass and pea species. The PEN2 glycosyl hydrolase localizes to peroxisomes and acts as a component of an inducible preinvasion resistance mechanism. Postinvasion fungal growth is blocked by a separate resistance layer requiring the EDS1-PAD4-SAG101 signaling complex, which is known to function in basal and resistance (R) gene-triggered immunity. Concurrent impairment of pre- and postinvasion resistance renders Arabidopsis a host for both nonadapted fungi.
authors.affiliation: Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl von Linné Weg 10, D-50829 Köln, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Lipka
authors.forename: Jan
authors.initials: J
authors.lastname: Dittgen
authors.forename: Pawel
authors.initials: P
authors.lastname: Bednarek
authors.forename: Riyaz
authors.initials: R
authors.lastname: Bhat
authors.forename: Marcel
authors.initials: M
authors.lastname: Wiermer
authors.forename: Monica
authors.initials: M
authors.lastname: Stein
authors.forename: Jörn
authors.initials: J
authors.lastname: Landtag
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Brandt
authors.forename: Sabine
authors.initials: S
authors.lastname: Rosahl
authors.forename: Dierk
authors.initials: D
authors.lastname: Scheel
authors.forename: Francisco
authors.initials: F
authors.lastname: Llorente
authors.forename: Antonio
authors.initials: A
authors.lastname: Molina
authors.forename: Jane
authors.initials: J
authors.lastname: Parker
authors.forename: Shauna
authors.initials: S
authors.lastname: Somerville
authors.forename: Paul
authors.initials: P
authors.lastname: Schulze-Lefert
mesh_terms: D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000502:physiology*; D001203:Ascomycota / Q000502:physiology; D002265:Carboxylic Ester Hydrolases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D009154:Mutation; D009699:N-Glycosyl Hydrolases / Q000502:physiology*; D020675:Peroxisomes / Q000502:physiology; D010838:Phytophthora / Q000502:physiology; D010935:Plant Diseases / Q000382:microbiology*; D050765:Qa-SNARE Proteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; C118837:EDS1 protein, Arabidopsis; C479425:PEN1 protein, Arabidopsis; D050765:Qa-SNARE Proteins; D002265:Carboxylic Ester Hydrolases; C400766:PAD4 protein, Arabidopsis; C460108:SAG101 protein, Arabidopsis; D009699:N-Glycosyl Hydrolases; C505663:PEN2 protein, Arabidopsis