title: A review of clinical and histological features of Spanish paediatric medulloblastomas during the last 21 years.
abstract: OBJECTIVE
  To find any feature of prognostic significance among the clinical and histological characteristics of paediatric patients diagnosed with medulloblastoma (MB).
  
  
  METHODS
  Clinical charts and paraffin blocks of 79 paediatric patients from nine Spanish institutions diagnosed with MB between 1980 and 2001 were reviewed retrospectively. Included clinical and histological characteristics were age, sex, duration of symptoms, physical signs on admission, tumour location, T and M stages of Chang classification, hydrocephalus, cerebrospinal fluid shunt, surgical resection, complications after surgery, MB subtype, desmoplasia, nodularity, fibrilar pattern, nuclear pleomorphism, necrosis grade, proliferation index and intra-tumoural vascularity. Overall and event-free survival (EFS) univariate and multivariate analyses were assessed.
  
  
  RESULTS
  Type of surgery and necrosis grade appeared to be independent prognostic variables in overall and EFSs. Although nuclear pleomorphism and intra-tumoural vascularity showed a marginally statistical effect on overall survival (OS), both had a significant influence on EFS.
  
  
  CONCLUSIONS
  We have confirmed surgical resection and added necrosis grade as independent prognostic factors in terms of OS for children diagnosed with MB.
authors.affiliation: Paediatric Oncology Unit, Hospital de Cruces, 48903, Barakaldo, Bizkaia, Spain. aurberuaga@yahoo.es
authors.forename: Alejandro
authors.initials: A
authors.lastname: Urberuaga
authors.forename: Aurora
authors.initials: A
authors.lastname: Navajas
authors.forename: Juan
authors.initials: J
authors.lastname: Burgos
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Pijoán
mesh_terms: D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008527:Medulloblastoma / Q000145:classification / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology