APOE epsilon4 is not associated with Alzheimer's disease in elderly Nigerians.
Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE epsilon4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions.
Gureje
Oye
O
Department of Psychiatry, University of Ibadan, College of Medicine, Ibadan, Nigeria.
Ogunniyi
Adesola
A
Baiyewu
Olusegun
O
Price
Brandon
B
Unverzagt
Frederick W
FW
Evans
Rebecca M
RM
Smith-Gamble
Valerie
V
Lane
Kathleen A
KA
Gao
Sujuan
S
Hall
Kathleen S
KS
Hendrie
Hugh C
HC
Murrell
Jill R
JR
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism*; D005006:Ethnicity; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008403:Mass Screening; D009549:Nigeria / Q000453:epidemiology; D020033:Protein Isoforms / Q000378:metabolism*; D012307:Risk Factors
D001057:Apolipoproteins E; D020033:Protein Isoforms