Asymmetric conjugate addition of copper reagents to alpha,beta-unsaturated tert-butanesulfinyl imines.
[reaction: see text] Addition of organocuprates to N-sulfinyl alpha,beta-unsaturated imines proceeds in good yields and with good diastereoselectivities. alpha,beta-Unsaturated sulfinyl ketimines and aldimines have both been shown to be suitable substrates for this reaction.
McMahon
Jeffrey P
JP
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720, USA.
Ellman
Jonathan A
JA