Substituted indanylacetic acids as PPAR-alpha-gamma activators.
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
Lowe
Derek B
DB
Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. derek.lowe@bayer.com
Bifulco
Neil
N
Bullock
William H
WH
Claus
Thomas
T
Coish
Philip
P
Dai
Miao
M
Dela Cruz
Fernando E
FE
Dickson
David
D
Fan
Dongping
D
Hoover-Litty
Helana
H
Li
Tindy
T
Ma
Xin
X
Mannelly
Gretchen
G
Monahan
Mary-Katherine
MK
Muegge
Ingo
I
O'Connor
Stephen
S
Rodriguez
Mareli
M
Shelekhin
Tatiana
T
Stolle
Andreas
A
Sweet
Laurel
L
Wang
Ming
M
Wang
Yamin
Y
Zhang
Chengzhi
C
Zhang
Hai-Jun
HJ
Zhang
Mingbao
M
Zhao
Kake
K
Zhao
Qian
Q
Zhu
Jian
J
Zhu
Lei
L
Tsutsumi
Manami
M
D000085:Acetates / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D008024:Ligands; D051379:Mice; D008817:Mice, Mutant Strains; D008820:Mice, Obese; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D000085:Acetates; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008024:Ligands; D010080:Oxazoles; D047493:PPAR alpha; D047495:PPAR gamma; D014280:Triglycerides