[Melanoma-stroma interactions and melanoma progression].
Cutaneous melanoma is an aggressive tumor which can metastasize early in its course. Not only the melanoma cells but also the tumor microenvironment play an important role in tumor development and progression. We review the structural and functional aspects of interactions between melanoma cells and the stroma and discuss some clinical implications.
Ruiter
Dirk J
DJ
Department of Pathology, University Medical Center, Nijmegen, The Netherlands. d.ruiter@pathol.azn.nl
Herlyn
Meenhard
M
D014408:Biomarkers, Tumor; D002450:Cell Communication; D018450:Disease Progression; D042783:Endothelial Cells / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D005819:Genetic Markers; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D011379:Prognosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D017154:Stromal Cells / Q000473:pathology*
D014408:Biomarkers, Tumor; D005819:Genetic Markers