title: Antidiarrhoeal activity of the ethanol extract of Paederia foetida Linn. (Rubiaceae).
abstract: Paederia foetida L. is used as a remedy for diarrhoea and dysentery in Asia, but has not been investigated for its antidiarrhoeal properties. Antidiarrhoeal activity of 90% ethanol extract of Paederia foetida was investigated in this study using castor oil and magnesium sulphate-induced diarrhoea models in mice. The extract significantly increased the latent period of diarrhoea in both the models. In the castor oil study, the purging index (PI) value lowered in 1 h of the study at (100, 250 and 500 mg/kg) doses. The effect continued up to 6-h period only at 500 mg/kg dose. The plant notably reduced the purging index value in a dose-dependent manner in magnesium sulphate-induced diarrhoea. Paederia foetida, in general, reduced the gastrointestinal motility with barium sulphate milk both in 15- and 30-min time intervals. The extract significantly decreased the cisplatin-induced gastrointestinal motility at all doses at both time intervals. The extract also enhanced the morphine-induced reduction of motility at 500 mg/kg dose level at both time intervals. The results suggest that Paederia foetida showed antidiarrhoeal activity by inhibiting intestinal motility and justify its use in traditional medicine.
authors.affiliation: Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: S
authors.initials: S
authors.lastname: Afroz
authors.forename: M
authors.initials: M
authors.lastname: Alamgir
authors.forename: M T H
authors.initials: MT
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Jabbar
authors.forename: N
authors.initials: N
authors.lastname: Nahar
authors.forename: M S K
authors.initials: MS
authors.lastname: Choudhuri
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D000431:Ethanol