Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea.
BACKGROUND
Autosomal dominant chronic mucocutaneous candidiasis (CMC) without endocrinopathy (OMIM 114580) is a well-described entity. The associations recorded with this disorder to date are intercellular adhesion molecule-1 (ICAM-1) deficiency and hyper-immunoglobulin E syndrome.


METHODS
We report a new association in a family (mother and nonidentical twin sons) where acne rosacea is a prominent feature together with CMC. In addition, antibodies to thyroid microsomal and antiparietal cell were also isolated. The autoantibodies might be associated with a current "latent" endocrinopathy in particular autoimmune thyroiditis.


METHODS
The patient was treated with intermittent pulses of itraconazole for the candidiasis and doxycycline initially before being substituted with isotretinoin 6 months later for the rosacea.


RESULTS
The patient's candidiasis responded well and has been in remission for 3 months while his rosacea continues to improve.
Ee
H L
HL
National Skin Centre, Singapore. melvinee@nsc.gov.sg
Tan
H H
HH
Ng
S K
SK
D000328:Adult; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D012393:Rosacea / Q000150:complications*