Unusually sulfated and oxygenated steroids from Withania somnifera.
Four (1, 8-10) and six known (2-7) withanolides were isolated from the leaves of Withania somnifera. Among the new compounds, 10 possessed the rare 3-O-sulfate group with the saturation in A ring and 9 contained unusual 1,4-dien-3-one group. Compound 8 did not have usual 2,3 unsaturation in A ring while 1 had the rare C-16 double bond. The structures of all the compounds were elucidated by spectroscopic methods and chemical transformation.
Misra
Laxminarain
L
Central Institute of Medicinal and Aromatic Plants, P.O.-CIMAP, Lucknow, UP 226 015, India. laxmisra@hotmail.com
Lal
Payare
P
Sangwan
Rajender S
RS
Sangwan
Neelam S
NS
Uniyal
Girish C
GC
Tuli
Rakesh
R
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification; D013431:Sulfates / Q000737:chemistry*; D032341:Withania / Q000737:chemistry*
D013256:Steroids; D013431:Sulfates; D010100:Oxygen