Horizontal transfer of erythromycin resistance from Clostridium difficile to Butyrivibrio fibrisolvens.
This study demonstrates for the first time the in vitro transfer of the erythromycin resistance gene erm(B) between two obligate anaerobes, the human spore-forming pathogen Clostridium difficile and the rumen commensal Butyrivibrio fibrisolvens, suggesting that this event might occur also in the natural environment.
Spigaglia
Patrizia
P
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Barbanti
Fabrizio
F
Mastrantonio
Paola
P
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D045856:Butyrivibrio / Q000187:drug effects / Q000235:genetics*; D002417:Cattle; D016360:Clostridioides difficile / Q000187:drug effects / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D008780:Methyltransferases / Q000235:genetics*; D008969:Molecular Sequence Data; D012417:Rumen / Q000382:microbiology
D001426:Bacterial Proteins; C111078:ErmTR protein, bacteria; D008780:Methyltransferases