Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Hecht
Stephen S
SS
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001564:Benzo(a)pyrene; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D008822:Mice, Transgenic; D009602:Nitrosamines; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020545:Respiratory Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D012402:Rotenone / Q000031:analogs & derivatives* / Q000494:pharmacology; D012907:Smoking / Q000009:adverse effects; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D002273:Carcinogens; D009602:Nitrosamines; D014028:Tobacco Smoke Pollution; D012402:Rotenone; D001564:Benzo(a)pyrene; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D051057:Proto-Oncogene Proteins c-akt; C107676:deguelin