title: Synthesis of 5-aminolevulinic acid (ALA) and its t-butyl ester for the fluorescence detection of early cancer.
abstract: 5-Aminolevulinic acid and its derivatives, which are known to affect the early diagnosis and treatment of cancer, have been synthesized. Simple methods for the synthesis of 5-aminolevulinic acid (ALA), a precursor of porphyrins, have been developed in our laboratory for use in studies on the biosynthesis of porphyrins.
authors.affiliation: College of Pharmacy, Kyung Hee University, Seoul, Korea.
authors.forename: Min-Seok
authors.initials: MS
authors.lastname: Kang
authors.forename: Dong-Myung
authors.initials: DM
authors.lastname: Kim
authors.forename: Jeong Sook
authors.initials: JS
authors.lastname: Kim
authors.forename: Jin-Hyun
authors.initials: JH
authors.lastname: Jeong
mesh_terms: D000622:Aminolevulinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D042241:Early Diagnosis; D005453:Fluorescence; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: C505153:5-aminolevulinic acid n-butyl ester; D000622:Aminolevulinic Acid