title: [Effects of He-Ne laser on gastric mucosa in rat with chronic atrophic gastritis].
abstract: This study sought to explore the effects of He-Ne laser irradiation on the gastric mucosa of experimental chronic atrophic gastritis (CAG) in rat. Fifty-two male adult Wistar rats were randomly divided into five groups including normal control group, model group and three different doses He-Ne laser groups. The CAG model in rats was made by administering (per gastrogavage) a compositus liquor, including 2% sodium salicylate and 30% alcohol, for 8 weeks to stimulate the rat's gastric mucosa, combined with irregular fasting and compulsive sporting as pathogenic factors. He-Ne laser therapy was used at different doses of He-Ne laser, once a day for twenty days, then the morphological changes and the expression of cyclinD1 were observed. Compared with untreated group, the gastric mucosa of 3.36J x cm(-2) He-Ne laser group was significantly thicker (P < 0.01), the inflammatory cells of gastric mucosa were decreased (P < 0.05), the morphology, structure and volume of the cells were restored or nearly normal and the expressions of cyclinD1 were higher (P < 0.05). In a word, small dose He-Ne laser (3.36 J x cm(-2)) has a good adjuvant therapeutic effect on rat's CAG.
authors.affiliation: Department of Medical Physics, Hebei North University, Zhangjiakou 075000, China.
authors.forename: Yueping
authors.initials: Y
authors.lastname: Yang
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wang
authors.forename: Xuehui
authors.initials: X
authors.lastname: Shao
authors.forename: Jie
authors.initials: J
authors.lastname: Dai
mesh_terms: D000818:Animals; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000473:pathology / Q000528:radiation effects*; D005757:Gastritis, Atrophic / Q000532:radiotherapy*; D028022:Low-Level Light Therapy; D008297:Male; D011230:Precancerous Conditions / Q000532:radiotherapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar