title: Effect of cetrorelix acetate on apoptosis and apoptosis regulatory factors in cultured uterine leiomyoma cells.
abstract: This report suggests the possibility that a gonadotropin-releasing hormone (GnRH) antagonist initiates apoptosis not only by causing a sex hormone deficit by inhibiting GnRH secretion in the pituitary gland, but also by acting directly on leiomyoma cells promoting apoptosis.
authors.affiliation: Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. jaykwon@yumc.yonsei.ac.kr
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Kwon
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Park
authors.forename: Young-Nyun
authors.initials: YN
authors.lastname: Park
authors.forename: Nam-Hoon
authors.initials: NH
authors.lastname: Cho
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology*; D014407:Tumor Cells, Cultured; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*
chemical_list: D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix