[Use of infusoria Paramecium caudatum for the evaluation of the toxicity of antigens of different causative quarantine agents].
The results of the evaluation of the toxicity of bacterial antigens obtained from the causative agents of plaque, glanders, melioidosis, cholera on infusoria of the species P. caudatum, as well as on cell lines L-929, CHO K-1 and peritoneal macrophages of BALB/c mice, are presented. As revealed in this study, the method of toxicity determination on infusoria is similar in its sensitivity to the methods of testing on. CHO K-1 and L-929 cells, but the former is simpler, more available and permits the determination of toxic doses producing disturbances in the vital activity of the infusoria, but not leading to their death.
Zhukova
S I
SI
Adel'shin
F K
FK
Khrapova
N P
NP
Piven'
N N
NN
Proshina
O B
OB
Zasiadkina
A V
AV
Plekhanova
N G
NG
Avrorova
I V
IV
D000818:Animals; D000942:Antigens, Bacterial / Q000633:toxicity*; D001431:Bacteriological Techniques / Q000379:methods*; D019117:Burkholderia / Q000276:immunology*; D016466:CHO Cells; D002460:Cell Line; D002772:Cholera Toxin / Q000633:toxicity*; D006224:Cricetinae; D017737:Macrophages, Peritoneal; D051379:Mice; D008807:Mice, Inbred BALB C; D048488:Paramecium caudatum / Q000166:cytology; D014617:Vacuoles / Q000378:metabolism; D015010:Yersinia pestis / Q000276:immunology*
D000942:Antigens, Bacterial; D002772:Cholera Toxin