title: Preliminary report on measurement of immunoglobulin IgG in Nigerian patients with dermatomyphytosis.
abstract: Thirty non-atopic adult Nigerian patients, with dermatophytosis, who showed no other demonstrable abnormality, and who denied any family history of atopy were studied for serum levels of immunoglobulin IgG. The results of serum gamma G. Immunoglobulin concentrations, as measured by the formation of precipitant rings using the Hyland technique in these patients, when compared with those in two control subjects and three other patients with trichophytide reactions, clearly showed much higher concentrations of IgG class of immunoglobulin in dermatophytosis. This finding thus supports an immunological role, as has been postulated by other investigators, in the pathogenosis of this disease. The high levels of this immunoglobulin in some of these patients calls for further study. Possible hypotheses are given. The serum levels of IgE levels of patients with "Ide Reaction" needs to be measured. The Hyland Immunoplate technique method of quantitation of immunoglobulins is described. The practising allergist can now measure most immunoglobulins.
authors.affiliation: Dermatology Unit, Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria.
authors.forename: A O
authors.initials: AO
authors.lastname: Somorin
authors.forename: I I
authors.initials: II
authors.lastname: Nwabudike
authors.forename: A I
authors.initials: AI
authors.lastname: Adetosoye
mesh_terms: D000328:Adult; D003881:Dermatomycoses / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male
chemical_list: D007074:Immunoglobulin G