title: Diffuse optical measurement of blood flow in breast tumors.
abstract: Blood flow contrast between tumor and normal tissues in patients with malignant and benign breast cancer was measured by diffuse optical correlation methods. The measurements were carried out with a hand-held optical probe that was manually scanned over the tumor-bearing breast. Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography.
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. durduran@stwing.upenn.edu
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Julia C
authors.initials: JC
authors.lastname: Tchou
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Czerniecki
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D001783:Blood Flow Velocity; D001943:Breast Neoplasms / Q000098:blood supply* / Q000473:pathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods