In vivo biodistribution of dendrimers and dendrimer nanocomposites -- implications for cancer imaging and therapy.
Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics different from PAMAM dendrimers in a B16 mouse tumor model system. We review important chemical and biologic uses of these nanodevices and discuss the potential of nanocomposite devices to greatly improve cancer imaging and therapy, in particular radiation therapy. We also discuss major issues confronting the use of nanoparticles in the near future, with consideration of toxicity analysis and whether biodegradable devices are needed or even desirable.
Khan
Mohamed K
MK
NanoBiotechnology Center at RPCI, Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Mohamed.khan@roswellpark.org
Nigavekar
Shraddha S
SS
Minc
Leah D
LD
Kariapper
Muhammed S T
MS
Nair
Bindu M
BM
Lesniak
Wojciech G
WG
Balogh
Lajos P
LP
D000818:Animals; D050091:Dendrimers / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D008297:Male; D008546:Melanoma, Experimental / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D049329:Nanostructures; D011073:Polyamines / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D050091:Dendrimers; D011073:Polyamines