title: Behavioral and social issues among volunteers in a preventive HIV vaccine trial in Thailand.
abstract: Behavioral and social issues were investigated in 363 phase I/II preventive HIV-1 vaccine trial volunteers in Thailand. These issues included risk behavior, HIV knowledge, distress, and social consequences of vaccine trial participation. Data were collected at baseline and at 4-, 8-, and 12-month follow-up visits. Volunteers reported relatively low levels of risk behaviors at baseline and at follow-up. Overtly negative reactions from family or friends were reported by 5.9%. No experiences of discrimination in employment, health care, or insurance were reported. Mean levels of distress were low throughout the trial, and HIV-related knowledge was high, although it was common to consider the possibility of HIV transmission through casual contact. Findings add to the evidence that preventive HIV vaccine trials are feasible in Thailand.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. rgj2@cdc.gov
authors.forename: Richard A
authors.initials: RA
authors.lastname: Jenkins
authors.forename: Darawan
authors.initials: D
authors.lastname: Thapinta
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Morgan
authors.forename: Siriluck
authors.initials: S
authors.lastname: Wongkamhaeng
authors.forename: Pornchai
authors.initials: P
authors.lastname: Sornsathapornkul
authors.forename: Valai
authors.initials: V
authors.lastname: Bussaratid
authors.forename: Auchara
authors.initials: A
authors.lastname: Sontirat
authors.forename: Punnee
authors.initials: P
authors.lastname: Pitisuttithum
authors.forename: Prasert
authors.initials: P
authors.lastname: Thongchareoen
authors.forename: Chirasak
authors.initials: C
authors.lastname: Khamboonruang
authors.forename: Vinai
authors.initials: V
authors.lastname: Suriyanon
authors.forename: Sorachai
authors.initials: S
authors.lastname: Nitayaphan
authors.forename: Arthur E
authors.initials: AE
authors.lastname: Brown
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D015497:HIV-1 / Q000276:immunology; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D012309:Risk-Taking; D012725:Sexual Behavior; D013785:Thailand; D014838:Volunteers / Q000523:psychology*
chemical_list: D016915:AIDS Vaccines