Intestinal absorption characteristics of ketoprofen in rats.
The present study aims to investigate the intestinal absorption characteristics of ketoprofen in rats. The pharmacokinetic profile of ketoprofen was evaluated following a single p.o. administration of ketoprofen (1 mg/kg) to rats in the absence and presence of benzoic acid or lactic acid (2 and 10 mg/kg), the substrates of monocarboxylic acid transporters. The pharmacokinetic profiles of ketoprofen (1 mg/kg) were significantly altered by the concurrent use of benzoic acid or lactic acid (10 mg/kg), compared with the control (given ketoprofen alone). The Cmax and AUC of ketoprofen in the presence of benzoic acid or lactic acid (10 mg/kg) were significantly (p<0.05) lower than those from the control group, while there was no significant change in Tmax and the terminal plasma half-life (T1/2) of ketoprofen. These results suggest that ketoprofen shares a common transport pathway with benzoic acid and lactic acid during the intestinal absorption in rats.
Choi
Jun-Shik
JS
College of Pharmacy, Cho-Sun University, Seosuk-dong, Gwangju, Korea.
Jin
Ming Ji
MJ
Han
Hyo-Kyung
HK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D019817:Benzoic Acid / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007408:Intestinal Absorption / Q000187:drug effects*; D007660:Ketoprofen / Q000493:pharmacokinetics*; D019344:Lactic Acid / Q000494:pharmacology; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D027501:Monocarboxylic Acid Transporters; D019344:Lactic Acid; D019817:Benzoic Acid; D007660:Ketoprofen