[Serum S-100B protein and neuron-specific enolase after traumatic brain injury].
OBJECTIVE
The aim of this study was to investigate S-100B protein and NSE as a serum marker of brain cell damage after traumatic brain injury.


METHODS
Forty-one patients with traumatic brain injury were included in this prospective study. Venous blood samples for S-100B protein and NSE were taken after admission and on the next day. Serum levels of S-100 protein and NSE were compared with Glasgow Coma Scale score, computed tomographic findings and outcome after 3 months.


RESULTS
Serum S-100B protein and NSE were significantly correlated with Glasgow Coma Scale score and outcome after 3 months. The significant correlation was found between the initial S-100B and NSE (P < 0.001). In patients without parenchymal injuries on computed tomographic scan such as epidural hematoma and concussion, the elevation of S-100B protein and NSE was observed. The initial values of S-100B and NSE in acute subdural hematomas with unfavorable outcome were significantly higher than in those with favorable outcome. Secondary increase of serum markers was associated with the presence of secondary insult such as hypoxia or hypotension, and was found to have an unfavorable outcome.


CONCLUSIONS
Serum concentration and kinetics of S-100B protein and NSE provide the clinical assessment of the primary brain damage and have a predictive value for outcome after traumatic brain injury.
Sawauchi
Satoshi
S
Department of Neurosurgery, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan. sawauchi@jb4.so-net.ne.jp
Taya
Keisuke
K
Murakami
Shigeyuki
S
Ishi
Takuya
T
Ohtsuka
Toshihiro
T
Kato
Naoki
N
Kaku
Shougo
S
Tanaka
Toshihide
T
Morooka
Satoru
S
Yuhki
Kenji
K
Urashima
Mitsuyoshi
M
Abe
Toshiaki
T
D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D009418:S100 Proteins / Q000097:blood*; D015599:Trauma Severity Indices
D015415:Biomarkers; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase