Inflammatory markers and hepatocyte growth factor in sustained hemodialysis hypotension.
Hypotension is an important complication of hemodialysis. The pathogenesis of this complication remains unclear. The role of chronic inflammation in chronic dialysis-associated hypotension has not been investigated. A total of 38 dialysis patients with chronic hypotension were identified. Their demographic and biochemical data, inflammatory markers (high sensitivity C-reactive protein [hs-CRP] and interleukin-6 [IL-6]), hepatocyte growth factor (HGF), leptin, and adiponectin levels were measured and compared with those of another 87 nonhypotensive dialysis patients. No between-group differences in their clinical features, underlying renal disease were found. Levels of serum albumin, leptin, adiponectin, and HGF were similar between the two groups. The serum albumin levels were inversely correlated with hs-CRP and IL-6. Adiponectin was negatively correlated with hs-CRP and leptin. HGF showed a positive relation with hs-CRP. No association was found between adiponectin and HGF. Therefore, chronic inflammation is prevalent in the dialysis population, and serum HGF level is associated with inflammation but not with chronic dialysis hypotension.
Lee
Chien-Te
CT
Division of Nephrology, Department of Medicine, Chang-Gung Memorial Hospital, Kaohsiung, Taiwan. ctlee33@adm.cgmh.org.tw
Hsu
Chung-Yao
CY
Lam
Kim-Kwan
KK
Lin
Chung-Ren
CR
Chen
Jin-Bor
JB
D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007022:Hypotension / Q000097:blood* / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012709:Serum Albumin / Q000032:analysis
D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D012709:Serum Albumin; D017228:Hepatocyte Growth Factor; D002097:C-Reactive Protein