Changes in bone metabolism in a rat model of traumatic brain injury.
OBJECTIVE
To evaluate the process of bone metabolism after traumatic brain injury.


METHODS
Randomized controlled trial.


METHODS
Rats were randomly assigned to either the brain injury group or to the sham-operation group using a fluid percussion device. The BMDs of lumbar vertebrae and proximal femur and bone turnover markers, osteocalcin and carboxy-terminal telopeptide, were measured at three points: the day before surgery and 1 and 3 weeks post-operatively. The biomechanics (maximum load of tibia and femoral neck) were measured 3 weeks post-operatively.


RESULTS
There was significant change in the BMDs of lumbar vertebrae 1 week post-operatively and of both distal femurs 3 weeks post-operatively (p < 0.05). A significant change in the maximum load of femoral neck was also observed 3 weeks post-operatively between the brain injury and the sham-operation groups (p = 0.044).


CONCLUSIONS
This finding suggests that brain injury could induce osteoporosis by immobilization.
Lee
Jong In
JI
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Korea.
Kim
Jong Hyun
JH
Kim
Hye Won
HW
Choi
Eun Suk
ES
Lim
Seong Hoon
SH
Ko
Young Jin
YJ
Han
Young Min
YM
D000818:Animals; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D001930:Brain Injuries / Q000378:metabolism*; D005260:Female; D005269:Femur / Q000502:physiology; D008159:Lumbar Vertebrae / Q000502:physiology; D023421:Models, Animal; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D015415:Biomarkers; D010455:Peptides; D015675:Osteocalcin