The case for strategic international alliances to harness nutritional genomics for public and personal health.
Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.
Kaput
Jim
J
Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA. jkaput@uic.edu
Ordovas
Jose M
JM
Ferguson
Lynnette
L
van Ommen
Ben
B
Rodriguez
Raymond L
RL
Allen
Lindsay
L
Ames
Bruce N
BN
Dawson
Kevin
K
German
Bruce
B
Krauss
Ronald
R
Malyj
Wasyl
W
Archer
Michael C
MC
Barnes
Stephen
S
Bartholomew
Amelia
A
Birk
Ruth
R
van Bladeren
Peter
P
Bradford
Kent J
KJ
Brown
Kenneth H
KH
Caetano
Rosane
R
Castle
David
D
Chadwick
Ruth
R
Clarke
Stephen
S
Clément
Karine
K
Cooney
Craig A
CA
Corella
Dolores
D
Manica da Cruz
Ivana Beatrice
IB
Daniel
Hannelore
H
Duster
Troy
T
Ebbesson
Sven O E
SO
Elliott
Ruan
R
Fairweather-Tait
Susan
S
Felton
Jim
J
Fenech
Michael
M
Finley
John W
JW
Fogg-Johnson
Nancy
N
Gill-Garrison
Rosalynn
R
Gibney
Michael J
MJ
Gillies
Peter J
PJ
Gustafsson
Jan-Ake
JA
Hartman
John L
JL
He
Lin
L
Hwang
Jae-Kwan
JK
Jais
Jean-Philippe
JP
Jang
Yangsoo
Y
Joost
Hans
H
Junien
Claudine
C
Kanter
Mitchell
M
Kibbe
Warren A
WA
Koletzko
Berthold
B
Korf
Bruce R
BR
Kornman
Kenneth
K
Krempin
David W
DW
Langin
Dominique
D
Lauren
Denis R
DR
Ho Lee
Jong
J
Leveille
Gilbert A
GA
Lin
Su-Ju
SJ
Mathers
John
J
Mayne
Michael
M
McNabb
Warren
W
Milner
John A
JA
Morgan
Peter
P
Muller
Michael
M
Nikolsky
Yuri
Y
van der Ouderaa
Frans
F
Park
Taesun
T
Pensel
Norma
N
Perez-Jimenez
Francisco
F
Poutanen
Kaisa
K
Roberts
Matthew
M
Saris
Wim H M
WH
Schuster
Gertrud
G
Shelling
Andrew N
AN
Simopoulos
Artemis P
AP
Southon
Sue
S
Tai
E Shyong
ES
Towne
Bradford
B
Trayhurn
Paul
P
Uauy
Ricardo
R
Visek
Willard J
WJ
Warden
Craig
C
Weiss
Rick
R
Wiencke
John
J
Winkler
Jack
J
Wolff
George L
GL
Zhao-Wilson
Xi
X
Zucker
Jean-Daniel
JD
D000818:Animals; D004195:Disease Models, Animal; D004435:Eating; D004777:Environment; D014644:Genetic Variation / Q000235:genetics; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D007391:International Cooperation; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D010641:Phenotype; D012106:Research