title: Preparation of finely dispersed drugs. III. Cyclosporine.
abstract: Two different precipitation processes are described, which produced dispersions of spherical particles of cyclosporine ranging in diameter from approximately 10 nm to several micrometers. This drug is of interest for its immunosuppressive activity in the antirejection of transplanted organs. The effects of several experimental parameters on the average particles size and uniformity have been investigated. Aging of spherical particles resulted in large crystalline-type aggregates.
authors.affiliation: Center for Advanced Material Processing (CAMP), Clarkson University, Potsdam, New York, 13699-5814, USA.
authors.forename: Laurent
authors.initials: L
authors.lastname: Joguet
authors.forename: Egon
authors.initials: E
authors.lastname: Matijevi
mesh_terms: D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical; D003102:Colloids; D016572:Cyclosporine / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres
chemical_list: D003102:Colloids; D007166:Immunosuppressive Agents; D016572:Cyclosporine