Transient paralysis after administration of a single dose of cyclizine.
Two patients with underlying neuromuscular disorders developed varying degrees of paralysis after a single dose of cyclizine, one necessitating full mechanical ventilation. These cases appear to be unique in the literature and represent an increasing spectrum of adverse reactions seen with the greater use of cyclizine.
Sandhu
S
S
Department of Anaesthetics and Critical Care, Newcastle upon Tyne NE7 7DN, UK.
Clarke
T N S
TN
Greaves
D
D
Ryan
D W
DW
D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D002091:Butyrylcholinesterase / Q000172:deficiency; D003501:Cyclizine / Q000009:adverse effects*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D009468:Neuromuscular Diseases / Q000150:complications; D010243:Paralysis / Q000139:chemically induced* / Q000209:etiology
D000932:Antiemetics; D002091:Butyrylcholinesterase; D003501:Cyclizine