[Different histological changes of hard palates in rats with different areas of denudated bone].
OBJECTIVE
To explore the relationship between the histological changes of the denudated bone in the hard palate of rats and its sizes.


METHODS
Sixteen three-week-old SD male rats were randomly divided into 4 groups (a control group and 3 experimental groups). In the three experimental groups, one and two and three quarters of the bilateral palatal mucoperiosteum were excised respectively. One animal in each group was sacrificed every two weeks and the histological differences were observed.


RESULTS
Different histological changes were found among the groups. When the denuded part was over half of the palate, tight connections between scar tissues and both the palatal bone and the periodontal fibers were observed. Many necrotic bone tissues appeared in the mid-palate if more than three quarters of areas were exposed.


CONCLUSIONS
Different sizes of denuded bone may lead to different histological appearances. Structures and tissues change more when denuded part of the bone is larger.
Huang
Xu
X
Surgical Department of Cleft Lip and Palate, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China.
Shi
Bing
B
Song
Qing-gao
QG
Li
Sheng
S
Lu
Yong
Y
D000818:Animals; D008297:Male; D009061:Mouth Mucosa / Q000033:anatomy & histology*; D021362:Palate, Hard / Q000033:anatomy & histology*; D010521:Periosteum / Q000033:anatomy & histology*; D051381:Rats; D014945:Wound Healing / Q000502:physiology*