Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide.
The kinetics decomposition of 2-chloroethylnitrososulfamides (CENS) was studied in aqueous buffered solutions with pH ranging from 0 to 14. The study was monitored by RP-LC-MS and conventional UV spectrophotometry. The reaction proceeded via a pseudo-first-order kinetic with significant correlation coefficient. The major decomposition products from CENS after incubation in phosphate buffer were isolated and identified by NMR and mass spectrometry. The results indicate that the mechanism pathway involves a denitrosation of the CENS and competitive hydrolysis with nucleophilic attack on the sulfur atom and formation of sulfamate compounds.
Seridi
Achour
A
Laboratoire de Chimie Appliquée, Université de Guelma, BP 401, 24000 Guelma, Algeria.
Kadri
Mekki
M
Abdaoui
Mohamed
M
Winum
Jean-Yves
JY
Montero
Jean-Louis
JL
D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry
D018906:Antineoplastic Agents, Alkylating; D009603:Nitroso Compounds; D013449:Sulfonamides; D014867:Water