title: Gray matter decrease in patients with chronic tension type headache.
abstract: Using MRI and voxel-based morphometry, the authors investigated 20 patients with chronic tension type headache (CTTH) and 20 patients with medication-overuse headache and compared them to 40 controls with no headache history. Only patients with CTTH demonstrated a significant gray matter decrease in regions known to be involved in pain processing. The finding implies that the alterations are specific to CTTH rather than a response to chronic head pain or chronification per se.
authors.affiliation: Department of Neurology, University of Regensburg, Regensburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Schmidt-Wilcke
authors.forename: E
authors.initials: E
authors.lastname: Leinisch
authors.forename: A
authors.initials: A
authors.lastname: Straube
authors.forename: N
authors.initials: N
authors.lastname: Kämpfe
authors.forename: B
authors.initials: B
authors.lastname: Draganski
authors.forename: H C
authors.initials: HC
authors.lastname: Diener
authors.forename: U
authors.initials: U
authors.lastname: Bogdahn
authors.forename: A
authors.initials: A
authors.lastname: May
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001284:Atrophy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D051271:Headache Disorders, Secondary / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D018781:Tension-Type Headache / Q000175:diagnosis* / Q000503:physiopathology; D014363:Tryptamines / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines