title: Preorganization in highly enantioselective diaza-Cope rearrangement reaction.
abstract: Crystal structure and activation entropy data indicate that H-bond directed diaza-Cope rearrangement of chiral diimines takes place with a high degree of preorganization. CD spectroscopy and HPLC data show that there is inversion of stereochemistry for the reaction with excellent enantioselectivity.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto M5S 3H6, Canada.
authors.forename: Hae-Jo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyunwoo
authors.initials: H
authors.lastname: Kim
authors.forename: Gamil
authors.initials: G
authors.lastname: Alhakimi
authors.forename: Eui June
authors.initials: EJ
authors.lastname: Jeong
authors.forename: Nirusha
authors.initials: N
authors.lastname: Thavarajah
authors.forename: Lisa
authors.initials: L
authors.lastname: Studnicki
authors.forename: Alicja
authors.initials: A
authors.lastname: Koprianiuk
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Lough
authors.forename: Junghun
authors.initials: J
authors.lastname: Suh
authors.forename: Jik
authors.initials: J
authors.lastname: Chin