title: [Linezolid, the first oxazolidinone antibiotic].
abstract: The spread of multiresistant Staphylococcus and Enterococcus strains required the development of new drugs. Linezolid is the first molecule of a new antibiotic family, oxazolidinones, with an original mechanism of action. In this general review, the authors first present its antibacterial activity, its pharmacokinetic properties, its therapeutic uses in serious Gram-positive infections, pneumonia, skin and soft tissue infections, and also in other indications. They then explain the rules for administration and tolerability.
authors.affiliation: Fédération de maladies infectieuses, groupe hospitalier Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. herve.dutronc@chu-bordeaux.fr
authors.forename: H
authors.initials: H
authors.lastname: Dutronc
authors.forename: F
authors.initials: F
authors.lastname: Bocquentin
authors.forename: T
authors.initials: T
authors.lastname: Galpérine
authors.forename: S
authors.initials: S
authors.lastname: Lafarie-Castet
authors.forename: M
authors.initials: M
authors.lastname: Dupon
mesh_terms: D000081:Acetamides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016983:Enterococcus / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011500:Protein Synthesis Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013210:Staphylococcus / Q000187:drug effects*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D011500:Protein Synthesis Inhibitors; D000069349:Linezolid