title: Pesticide exposure and lung cancer mortality in Leningrad province in Russia.
abstract: This study was carried out to examine the association between pesticide exposure and lung cancer mortality. We conducted an autopsy based case-control study in Leningrad Province in Russia. A total of 540 lung cancer cases and 582 controls were identified among subjects who had died in the hospitals of the Leningrad province between 1993 and 1998. Using work history records, we assessed exposure to pesticide at the level of industry and job title. Unconditional logistic regression was used to calculate adjusted odds ratio for pesticide exposure and lung cancer mortality. There was no association between ever exposure to pesticide and lung cancer mortality overall (odds ratio=1.06, 95% confidence interval=0.82-1.36) and in both men (odds ratio=1.11, 95% confidence interval=0.84-1.46) and women (odds ratio=0.74, 95% confidence interval=0.37-1.46). We observed no statistically significant odds ratio by duration of pesticide exposure, intensity of pesticide exposure, and cumulative pesticide exposures with lung cancer mortality in both smokers and nonsmokers. Odds ratio also did not differ when the analysis was restricted to individuals who had exposure data with high confidence scores. Our findings suggest no associations between pesticide exposures and mortality of lung cancer in the population of the Leningrad province in Russia that deserves further evaluation.
authors.affiliation: Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea. leewj@korea.ac.kr
authors.forename: Won Jin
authors.initials: WJ
authors.lastname: Lee
authors.forename: Andrea
authors.initials: A
authors.lastname: Baccarelli
authors.forename: Maria
authors.initials: M
authors.lastname: Tretiakova
authors.forename: Sergey
authors.initials: S
authors.lastname: Gorbanev
authors.forename: Alexei
authors.initials: A
authors.lastname: Lomtev
authors.forename: Irina
authors.initials: I
authors.lastname: Klimkina
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tchibissov
authors.forename: Olga
authors.initials: O
authors.lastname: Averkina
authors.forename: Mustafa
authors.initials: M
authors.lastname: Dosemeci
mesh_terms: D000368:Aged; D000395:Air Pollutants, Occupational / Q000633:toxicity; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity*; D012426:Russia / Q000453:epidemiology
chemical_list: D000395:Air Pollutants, Occupational; D010575:Pesticides