A new method for translating the asymmetric Ni/Cr-mediated coupling reactions from stoichiometric to catalytic.
[reaction: see text] A new method has been developed for effectively translating the degree of asymmetric induction and the chemical yield achieved in the stoichiometric asymmetric Ni/Cr-mediated coupling to a catalytic asymmetric process via a chiral sulfonamide ligand. It has also been shown that the Ni catalyst plays a central role. Among a number of the Ni catalysts, the 2,9-dimethylphenanthroline/NiCl(2) complex (7) has been found to be the most effective.
Namba
Kosuke
K
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Cui
Sheng
S
Wang
Jiashi
J
Kishi
Yoshito
Y
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D002857:Chromium / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry
D001555:Benzene Derivatives; D013449:Sulfonamides; D002857:Chromium; D009532:Nickel