CspA regulates pigment production in Staphylococcus aureus through a SigB-dependent mechanism.
We report that the cold shock protein CspA of Staphylococcus aureus is required for maximal production of pigment. Results from transcriptional studies revealed that loss of CspA resulted in decreased expression of genes needed for the biosynthesis of 4,4'-diaponeurosporene and the alternative sigma factor SigB.
Katzif
Samuel
S
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Lee
Eun-Hee
EH
Law
Anthony B
AB
Tzeng
Yih-Ling
YL
Shafer
William M
WM
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002338:Carotenoids / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D010860:Pigments, Biological / Q000096:biosynthesis*; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism; D013211:Staphylococcus aureus / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014315:Triterpenes / Q000378:metabolism
D001426:Bacterial Proteins; D010860:Pigments, Biological; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D014157:Transcription Factors; D014315:Triterpenes; C062260:cold shock protein CS7.4, Bacteria; D002338:Carotenoids; C091058:4,4'-diaponeurosporene