title: The influence of amphetamine on language activation: an fMRI study.
abstract: BACKGROUND
  Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language.
  
  
  METHODS
  To test this hypothesis, language activation was measured twice with functional magnetic resonance imaging in ten healthy right-handed men in a double-blind crossover design 2 h after amphetamine or placebo administration.
  
  
  RESULTS
  Language-related activation increased significantly in task-related areas, but the individual lateralization index was not affected in the amphetamine condition as compared to placebo.
  
  
  CONCLUSIONS
  This finding suggests that short-termed alterations in the dopaminergic neurotransmission do not affect language dominance.
authors.affiliation: Rudolf Magnus Institute of Neuroscience Psychiatry Department, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands. I.Sommer@azu.nl
authors.forename: Iris E C
authors.initials: IE
authors.lastname: Sommer
authors.forename: Bob
authors.initials: B
authors.lastname: Oranje
authors.forename: Nick F
authors.initials: NF
authors.lastname: Ramsey
authors.forename: Floris A
authors.initials: FA
authors.lastname: Klerk
authors.forename: René C W
authors.initials: RC
authors.lastname: Mandl
authors.forename: Herman G M
authors.initials: HG
authors.lastname: Westenberg
authors.forename: René S
authors.initials: RS
authors.lastname: Kahn
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000097:blood / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001931:Brain Mapping; D000697:Central Nervous System Stimulants / Q000097:blood / Q000494:pharmacology*; D018592:Cross-Over Studies; D003657:Decision Making / Q000187:drug effects; D004311:Double-Blind Method; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects; D013060:Speech / Q000187:drug effects
chemical_list: D000697:Central Nervous System Stimulants; D000661:Amphetamine