Effects of diacylglycerol on postprandial energy expenditure and respiratory quotient in healthy subjects.
OBJECTIVE
This study examined the effects of a diacylglycerol (DAG)-containing diet on postprandial energy expenditure and respiratory quotient.


METHODS
A randomized, double-blind, crossover, placebo-controlled study with a washout period was performed in 13 healthy male subjects. A 4240-kJ diet containing 30 g of triacylglycerol (TAG) or DAG (TAG meal or DAG meal, containing 34.5% lipids, 52.1% carbohydrates, and 14.1% proteins) was administered after a fasting period of 15 to 16 h. Breath and serum were analyzed for up to 5 h after ingestion of the meal.


RESULTS
The amount of change in energy expenditure 3 h after loading with the DAG meal tended to be higher than that after loading with the TAG meal (P < 0.1). Changes in respiratory quotient 2 and 5 h after loading with the DAG meal were significantly lower than those after loading with the TAG meal, suggesting high lipid oxidation activity after the meal. The serum insulin level 0.5 h after loading with the DAG meal was significantly lower than that after loading with the TAG meal. This result suggests that there is a smaller stimulus in the direction of fat storage after loading with the DAG meal.


CONCLUSIONS
Compared with the TAG-containing meal, the DAG-containing meal tended to produce a higher postprandial energy expenditure and a significantly lower postprandial respiratory quotient. These results suggest that the DAG-containing meal has high postprandial lipid oxidation activity and a potential effect on high diet-induced thermogenesis.
Saito
Shinichiro
S
Health Care Products Research Laboratories No. 1, Kao Corporation, Tokyo, Japan.
Tomonobu
Kazuichi
K
Hase
Tadashi
T
Tokimitsu
Ichiro
I
D000328:Adult; D019540:Area Under Curve; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism; D004075:Diglycerides / Q000008:administration & dosage* / Q000378:metabolism; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects*; D019518:Postprandial Period / Q000502:physiology; D022722:Thermogenesis / Q000187:drug effects / Q000502:physiology; D014280:Triglycerides / Q000008:administration & dosage / Q000378:metabolism
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D004075:Diglycerides; D007328:Insulin; D014280:Triglycerides