title: Hypotonic-hyporesponsive episode in a 7-month-old infant after receipt of multiple vaccinations.
abstract: A 7-month-old boy became difficult to arouse, was limp and had blue extremities 8 hours after immunization with intravenous poliovirus, diphtheria-tetanus toxoids-acellular pertussis, Haemophilus influenzae type b-hepatitis B virus and pneumococcal vaccines. The hypotonic-hyporesponsive episode had resolved by the time the infant was seen in an emergency department 1 hour later. The report describes hypotonic-hyporesponsive episode, encourages reporting of vaccine-associated adverse events and discusses prognosis and implications for subsequent immunization.
authors.affiliation: Department of Pediatrics, Akron Children's Hospital, Akron, OH, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: McPherson
authors.forename: Keith R
authors.initials: KR
authors.lastname: Powell
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D003490:Cyanosis / Q000139:chemically induced*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects; D018073:Haemophilus Vaccines / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects; D009123:Muscle Hypotonia / Q000139:chemically induced*; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects; D012449:Safety; D017778:Vaccines, Combined / Q000009:adverse effects*
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; D022542:Measles-Mumps-Rubella Vaccine; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined