title: Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation.
abstract: Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC(50) values of 2.9 and 1.7 microM, respectively, and they also inhibited cell-mediated LDL oxidation more than 5 times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 microM. Compound (1) had no effect on the anti-atherogenesis in low-density lipoprotein receptor-deficient mice.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kang
authors.forename: Ju
authors.initials: J
authors.lastname: Ryong Kim
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeomg
authors.forename: Sung-Gyu
authors.initials: SG
authors.lastname: Choi
authors.forename: Young-Han
authors.initials: YH
authors.lastname: Ryu
authors.forename: Goo
authors.initials: G
authors.lastname: Taeg Oh
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D029661:Alnus / Q000737:chemistry; D000818:Animals; D006536:Heptanes / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D010084:Oxidation-Reduction; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D006536:Heptanes; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances