title: Early onset of ganciclovir-resistant cytomegalovirus infection in a lung-transplant recipient.
abstract: Ganciclovir resistance in cytomegalovirus (CMV) is an increasing problem in lung-transplant recipients with adverse clinical outcomes. We experienced the successful treatment of ganciclovir-resistant CMV infection in a lung-transplant recipient still receiving CMV prophylaxis. A 24-year-old woman with lymphangioleiomyomatosis underwent a living-donor lobar lung transplantation. She was a primary CMV mismatch (D+/R-) patient. She recovered from her postoperative complications, and was about to be discharged. However, she suffered ganciclovir-resistant CMV infection during prophylactic therapy. She was successfully treated with foscarnet, and is now alive without recurrence 18 months after surgery.
authors.affiliation: Department of Thoracic Surgery, Kyoto University, Japan.
authors.forename: Fengshi
authors.initials: F
authors.lastname: Chen
authors.forename: Toru
authors.initials: T
authors.lastname: Bando
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Hanaoka
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Fukuse
authors.forename: Seiki
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Wada
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology*; D024882:Drug Resistance, Viral; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000494:pharmacology*; D006801:Humans; D016040:Lung Transplantation; D011183:Postoperative Complications
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D015774:Ganciclovir