title: Iron-responsive regulation of biofilm formation in staphylococcus aureus involves fur-dependent and fur-independent mechanisms.
abstract: We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.
authors.affiliation: Department of Genetics, University of Leicester, UK. jam26@le.ac.uk.
authors.forename: Miranda
authors.initials: M
authors.lastname: Johnson
authors.forename: Alan
authors.initials: A
authors.lastname: Cockayne
authors.forename: Peter H
authors.initials: PH
authors.lastname: Williams
authors.forename: Julie A
authors.initials: JA
authors.lastname: Morrissey
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development*; D003470:Culture Media; D015964:Gene Expression Regulation, Bacterial; D007501:Iron; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D013211:Staphylococcus aureus / Q000235:genetics / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron