title: TARGIT technology: coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract.
abstract: TARGIT technology (West Pharmaceutical Services) is designed for site-specific delivery of drugs in the gastrointestinal (GI) tract and, in particular, targeted release into the colonic region. A key area of application is the delivery of therapeutic agents for local treatment of lower GI diseases. The technology is based on the application of pH-sensitive coatings onto injection-moulded starch capsules. An extensive body of clinical data has been generated showing reliable in vivo performance of the capsules. In gamma-scintigraphy studies around 90% of TARGIT capsules (n = 84) delivered their contents to the target site of the terminal ileum and colon. TARGIT-based products are in active clinical development for the treatment of conditions including inflammatory bowel diseases.
authors.affiliation: West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited, Albert Einstein Centre, Nottingham Science & Technology Park, Nottingham, NG7 2TN, UK. peter.watts@westpharma.com
authors.forename: Peter
authors.initials: P
authors.lastname: Watts
authors.forename: Alan
authors.initials: A
authors.lastname: Smith
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D019819:Budesonide / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003106:Colon / Q000378:metabolism*; D016503:Drug Delivery Systems; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000503:physiopathology; D011109:Polymethacrylic Acids / Q000737:chemistry; D012995:Solubility; D013213:Starch / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D002214:Capsules; D005765:Gastrointestinal Agents; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D019819:Budesonide; D013213:Starch