Black foam films from aqueous solutions of a mixture of phospholipids and a permeation enhancer.
The influence of a permeation enhancer on the properties of phospholipid black foam films has been studied through the combination of three complementary techniques: surface tension measurements, X-ray reflectivity, and the "diminishing bubble" method. This permeation enhancer is said to optimize the delivery of active ingredients into or through the stratum corneum: the 4-decyl oxazolidin-2-one. We made films of a complex phospholipid mixture that mimic the behavior of the enhancer in a membrane cell. Mixed phospholipids/4-decyl oxazolidin-2-one/NaCl solutions were studied with various 4-decyl oxazolidin-2-one concentrations. Stable black films were obtained and their thicknesses examined. The evolution of the coefficient of gas permeability with 4-decyl oxazolidin-2-one concentration is also addressed.
Tranchant
Jean-François
JF
LVMH R&D, Avenue de Verdun, Saint Jean de Braye Cedex F-45804, France.
Bonté
Frédéric
F
Leroy
Sébastien
S
Nedyalkov
Mickael
M
Platikanov
Dimo
D
Javierre
Isabelle
I
Benattar
Jean-Jacques
JJ