title: Assays for thyroid-stimulating antibodies and thyrotropin-binding inhibitory immunoglobulins in children with Graves' disease.
abstract: Studies on thyrotropin receptor autoantibodies (TRAb) by measurement of both thyroid-stimulating antibodies (TSAb) and thyrotropin-binding inhibitory immunoglobulins (TBII) in serum from children with Graves' disease are limited in number of studies. The aim of this study was to investigate the levels of serum TSAb and TBII in children with Graves' disease, and to evaluate the clinical significance of these antibodies. We measured the serum TSAb and TBII at diagnosis and during management in 65 children with Graves' disease. Patients were divided into four groups according to their metabolic state: those with untreated active Graves' disease, those receiving treatment with antithyroid drugs, those in remission, and those in relapse. At diagnosis, both TSAb and TBII assays had high sensitivities and high specificities. In follow-up, the levels of both TSAb and TBII paralleled the course of the disease. There was a strong positive correlation between TSAb and TBII. TBII levels were significantly higher in the patients with ophthalmopathy than those without ophthalmopathy in untreated Graves' children. It was concluded that TSAb and TBII measurements are valuable in the diagnosis and management of children with Graves' disease.
authors.affiliation: Department of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Shibayama
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Ohyama
authors.forename: Yukifumi
authors.initials: Y
authors.lastname: Yokota
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Ohtsu
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Takubo
authors.forename: Nobuo
authors.initials: N
authors.lastname: Matsuura
mesh_terms: D000293:Adolescent; D013956:Antithyroid Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis* / Q000097:blood; D002648:Child; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology*; D049970:Graves Ophthalmopathy / Q000097:blood / Q000276:immunology; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood*; D008297:Male; D011989:Receptors, Thyrotropin / Q000097:blood / Q000276:immunology*; D012008:Recurrence; D012074:Remission Induction; D012680:Sensitivity and Specificity
chemical_list: D013956:Antithyroid Agents; D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin; C094372:thyrotropin-binding inhibitory immunoglobulin