title: A case of uterine cervical cancer presenting with granulocytosis.
abstract: Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granulocytosis. Leukocytosis developed up to 69,000/microL, and then normalized after chemo-radiotherapy. There was no evidence of infection, tumor necrosis, glucocorticoid administration, or myeloproliferative disease by examination of a bone marrow aspirate when granulocytosis appeared. This phenomenon was probably associated with the secretion of hematopoietic growth factors such as G-CSF, GM-CSF and IL-6 by the tumor. We suggest that, like some other solid tumors, cervical cancer can present with granulocytosis as a paraneoplastic syndrome.
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea.
authors.forename: Heui June
authors.initials: HJ
authors.lastname: Ahn
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Park
authors.forename: Yoon Hwan
authors.initials: YH
authors.lastname: Chang
authors.forename: Sun Hoo
authors.initials: SH
authors.lastname: Park
authors.forename: Min-Suk
authors.initials: MS
authors.lastname: Kim
authors.forename: Baek Yeol
authors.initials: BY
authors.lastname: Ryoo
authors.forename: Sung Hyun
authors.initials: SH
authors.lastname: Yang
mesh_terms: D005260:Female; D006098:Granulocytes / Q000473:pathology*; D006801:Humans; D007964:Leukocytosis / Q000209:etiology*; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D014594:Uterine Neoplasms / Q000150:complications / Q000175:diagnosis*