No evidence for association between dyslexia and DYX1C1 functional variants in a group of children and adolescents from Southern Italy.
Recently, DYX1C1, a candidate gene for developmental dyslexia, encoding a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain, has been characterized through a translocation breakpoint in a Finnish family. Two putatively functional variants, -3G/A and 1249G/T, have been reported to be significantly associated with dyslexia in this population. Further studies, conducted on different ethnic groups (English and Canadian), have not confirmed a role for DYX1C1 variants in increasing the risk for dyslexia. We investigated the role of these variants in dyslexic children and adolescents from Southern Italy. No significant evidence for association between dyslexia and these DYX1C1 putative functional variants has been shown. We argue that the different DYX1C1 allele frequencies shown among Italian and Finnish subjects with dyslexia could be attributable to the different linkage disequilibrium structure of these populations.
Bellini
Giulia
G
Chair of Child Neuropsychiatry, Department of Pediatrics, Second University of Naples, Naples, Italy.
Bravaccio
Carmela
C
Calamoneri
Filippo
F
Donatella Cocuzza
Maria
M
Fiorillo
Pasquale
P
Gagliano
Antonella
A
Mazzone
Domenico
D
del Giudice
Emanuele Miraglia
EM
Scuccimarra
Geoffredo
G
Militerni
Roberto
R
Pascotto
Antonio
A
D000293:Adolescent; D002648:Child; D003598:Cytoskeletal Proteins; D004410:Dyslexia / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005387:Finland; D005787:Gene Frequency; D006801:Humans; D007558:Italy; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
D003598:Cytoskeletal Proteins; C478878:DNAAF4 protein, human; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins