title: E3 ubiquitin ligases and their control of T cell autoreactivity.
abstract: A loss of T cell tolerance underlies the development of most autoimmune diseases. The design of therapeutic strategies to reinstitute immune tolerance, however, is hampered by uncertainty regarding the molecular mechanisms involved in the inactivation of potentially autoreactive T cells. Recently, E3 ubiquitin ligases have been shown to mediate the development of a durable state of unresponsiveness in T cells called clonal anergy. In this review, we will discuss the mechanisms used by E3 ligases to control the activation of T cells and prevent the development of autoimmunity.
authors.affiliation: Rheumatic and Autoimmune Diseases Division, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
authors.forename: Jody L
authors.initials: JL
authors.lastname: Bonnevier
authors.forename: Ruan
authors.initials: R
authors.lastname: Zhang
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Mueller
mesh_terms: D001327:Autoimmune Diseases / Q000201:enzymology* / Q000276:immunology*; D017635:Clonal Anergy / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases / Q000276:immunology*
chemical_list: D044767:Ubiquitin-Protein Ligases