title: Clinical and serological features of 35 patients with anti-Ki autoantibodies.
abstract: The objective of this study was to analyse clinical and serological associations of anti-Ki antibodies. Thirty-five patients with anti-Ki antibodies, detected by CIE, selected from laboratory routine, were studied. All patients were affected by autoimmune diseases: SLE and pSS were the most frequent diagnoses. The cohort was constituted by 27 female and eight males. Main clinical features were skin involvement (60%), xerophtalmia (48.6%), Raynaud's phenomenon (43%), photosensitivity (34%), xerostomia (31.4%). CNS involvement was present in four (11.4%) and renal disease in seven cases (20%). ANA, anti-dsDNA and RF were detected in 100%, 60% and 34.5%. In SLE, anti-Ki was detected in 6% of cases, more frequently in males compared to other SLE patients without anti-Ki (P < 0.004). Nineteen anti-Ki positive patients affected by SLE showed more frequently malar rash and multiple autoantibody specificities compared to 16 anti-Ki positive patients with other diseases (P = 0.044 and P = 0.0003, respectively). Our study confirms a preferential occurrence of anti-Ki antibodies in patients with sicca and skin involvement. Malar rash and multiple ANA specificities were significantly associated with SLE compared to other diseases in our study. Anti-Ki were detected in 6% of patients with SLE with a significant prevalence in males.
authors.affiliation: Rheumatology Unit and Chair, Spedali Civili, Brescia, Italy. cavazzana@bresciareumatologia.it
authors.forename: I
authors.initials: I
authors.lastname: Cavazzana
authors.forename: F
authors.initials: F
authors.lastname: Franceschini
authors.forename: C
authors.initials: C
authors.lastname: Vassalini
authors.forename: E
authors.initials: E
authors.lastname: Danieli
authors.forename: M
authors.initials: M
authors.lastname: Quinzanini
authors.forename: P
authors.initials: P
authors.lastname: Airò
authors.forename: R
authors.initials: R
authors.lastname: Cattaneo
mesh_terms: D000328:Adult; D000954:Antigens, Surface / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015331:Cohort Studies; D003378:Counterimmunoelectrophoresis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D046988:Proteasome Endopeptidase Complex / Q000276:immunology*; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000276:immunology*
chemical_list: D000954:Antigens, Surface; D001323:Autoantibodies; D001324:Autoantigens; C099558:Ki antigen; D046988:Proteasome Endopeptidase Complex