Long term morbidity of neoadjuvant chemoradiation for pancreatic head adenocarcinoma.
OBJECTIVE
To report the long term risks of neoadjuvant chemoradiation (NCRT) after duodenopancreatectomy (DP) for adenocarcinoma of the head of pancreas.


METHODS
Between January 1996 and December 2002, 26 patients with biopsy-proven adenocarcinoma of the head of pancreas were treated by this combination of therapies.


RESULTS
Two patients had delayed NCRT-related small bowel infarction: one died from superior mesenteric artery stenosis 36 months after DP without recurrence at laparotomy; there was one limited infarction 16 months after DP.


CONCLUSIONS
Long term vascular morbidity after NCRT is significant.
Turrini
O
O
Department of Surgical Oncology, Institut Paoli-Calmettes Marseille, 232 Boulevard Ste Marguerite, 13009 Marseille, France. oturrini@yahoo.fr
Moutardier
V
V
Guiramand
J
J
Viret
F
F
Giovaninni
M
M
Delpero
J R
JR
D000230:Adenocarcinoma / Q000188:drug therapy / Q000453:epidemiology* / Q000532:radiotherapy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D005500:Follow-Up Studies; D006801:Humans; D009017:Morbidity; D020360:Neoadjuvant Therapy; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000532:radiotherapy; D016577:Pancreaticoduodenectomy; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography
D000970:Antineoplastic Agents