Screening of plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity.
Aqueous and methanolic extracts of 11 plants, used in Danish folk medicine for improvement of memory and cognition, and 3 Corydalis species were tested for acetylcholinesterase inhibitory activity using the Ellman colorimetric method. Significant inhibitory activity in dose-dependent manner was observed for extracts of Corydalis cava, Corydalis intermedia, Corydalis solida ssp. laxa and Corydalis solida ssp. slivenensis. Extracts of Ruta graveolens, Lavandula angustifolia, Rosmarinus officinalis, Petroselinum crispum and Mentha spicata exhibited moderate inhibition of the enzyme, defined as more than 15% at 0.1 mg/ml.
Adsersen
Anne
A
Department of Medicinal Chemistry, The Danish University of Pharmaceutical sciences, 2 Universitetsparken, 2100 Copenhagen O, Denmark. aad@dfuni.dk
Gauguin
Bente
B
Gudiksen
Lene
L
Jäger
Anna K
AK
D000110:Acetylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D003718:Denmark; D004305:Dose-Response Relationship, Drug; D008519:Medicine, Traditional; D008569:Memory Disorders / Q000188:drug therapy*; D018697:Nootropic Agents / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal
D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents; D010936:Plant Extracts; D000110:Acetylcholinesterase