title: Sodium selenite protects against diabetes-induced alterations in the antioxidant defense system of the liver.
abstract: BACKGROUND
  Free radical genesis of disorder is one of the major subjects of discussion in the explanation of pathological conditions. In this study, the effects of micro molar quantities of sodium selenite treatment on diabetes-induced alterations in the antioxidant defense system were investigated.
  
  
  METHODS
  Diabetes was induced by administration of streptozotocin (STZ, 50 mg/kg body weight) and both diabetic and control animals were treated with sodium selenite (5 micromol/kg/day) for 4 weeks.
  
  
  RESULTS
  Our results have shown that induction of diabetes in the liver tissue of animals for 5 weeks resulted in decreased superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GSHPx) activities and concomitantly increased lipid peroxidation (LPO).
  
  
  CONCLUSIONS
  Sodium selenite treatment of the diabetic rats resulted in almost full restoration of all the parameters mentioned above. Metallothionein, which is known to be one of the major antioxidants and a central protein in heavy metal regulation, is altered by diabetes, and sodium selenite treatment restored this alteration as well.
authors.affiliation: Department of Biophysics, Meram Medical Faculty, Selçuk University, 42080 Konya, Turkey. mayaz@selcuk.edu.tr
authors.forename: Murat
authors.initials: M
authors.lastname: Ayaz
authors.forename: Handan Ak
authors.initials: HA
authors.lastname: Celik
authors.forename: Hikmet Hakan
authors.initials: HH
authors.lastname: Aydin
authors.forename: Belma
authors.initials: B
authors.lastname: Turan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000517:prevention & control; D005260:Female; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018038:Sodium Selenite