[Pharmacological modulation of phagocytosis of granulocytes and monocytes in patients with familial Mediterranean fever].
Disturbances in the regulation of phagocytic activity of neutrophils and monocytes (PANM) in whole peripheral blood of patients with Familial Mediterranean Fever (FMF), which had not receive treatment with colchicines, and the effect of drugs from various pharmacological groups on the PANM in the blood of these patients were studied in vitro by quantitative flow cytofluorimetry. A comparative study of the drug action showed that the most effective PANM inhibitors during FMF are colchicine and iodine-lithium-alpha-dextrin (armenicum), while synthetic glucocorticoids and sodium thiosulfate showed low activity and produced no significant effect. It was established that armenicum is capable of modulating the PANM-inhibition effect of colchicine, neutralizing the effect of TNF, and increasing the effect of glucocorticoids. was observed. Sodium thiosulfate produces inhibition of the activity of armenicum.
Avetisian
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SA
D000293:Adolescent; D000328:Adult; D010505:Familial Mediterranean Fever / Q000276:immunology*; D005260:Female; D006098:Granulocytes / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008297:Male; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*