A new chemical tool for exploring the physiological function of the PDE2 isozyme.
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
Chambers
Robert J
RJ
Research Technology Center, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA. Robert.J.Chambers@pfizer.com
Abrams
Kristin
K
Garceau
Norman Y
NY
Kamath
Ajith V
AV
Manley
Christopher M
CM
Lilley
Susan C
SC
Otte
Douglas A
DA
Scott
Dennis O
DO
Sheils
Alissa L
AL
Tess
David A
DA
Vellekoop
A Samuel
AS
Zhang
Yan
Y
Lam
Kelvin T
KT
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D054678:Cyclic Nucleotide Phosphodiesterases, Type 2; D004353:Drug Evaluation, Preclinical; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D007527:Isoenzymes / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D000078183:Oxindoles; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D010727:Phosphoric Diester Hydrolases / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012995:Solubility; D013329:Structure-Activity Relationship
D007211:Indoles; D007527:Isoenzymes; D000078183:Oxindoles; D010726:Phosphodiesterase Inhibitors; C022960:2-oxindole; C010192:9-(2-hydroxy-3-nonyl)adenine; D010727:Phosphoric Diester Hydrolases; D054678:Cyclic Nucleotide Phosphodiesterases, Type 2; C517278:Pde2a protein, rat; D000225:Adenine