title: Growth-reductive therapy in children with marfan syndrome.
abstract: OBJECTIVE
  To determine the accuracy and precision of 2 height-prediction methods in Marfan syndrome and to assess the growth-reductive effect and side effects of sex hormone treatment.
  
  
  METHODS
  In a retrospective study in 31 untreated (17 boys) and 43 treated patients (21 boys) with Marfan syndrome, we assessed bone age and predicted adult height by 2 methods. The accuracy of the methods was assessed in the untreated group. The effect of therapy was corrected for outcome in the untreated group and other confounding variables with multivariate analysis.
  
  
  RESULTS
  Accuracy strongly varied with sex, chronological age, and prediction method. Overall precision was low. Treatment was started at a mean age of 12.8 +/- 1.4 years (boys) and 11.4 +/- 1.2 years (girls). With multiple regression analysis, a statistically significant effect was observed only in boys using a pharmacologic dosage (5.5 cm, 95% CI 0.96-10.1 cm; P = .02). Side effects were worsening of acne and weight and muscle gain.
  
  
  CONCLUSIONS
  In adolescents with Marfan syndrome, the accuracy and precision of 2 height-prediction methods were limited. The apparent growth-reductive effect of sex hormone treatment appears similar to earlier reports on adolescents with constitutional tall stature. There were no clinically important short-term side effects.
authors.affiliation: Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands. l.rozendaal@lumc.nl
authors.forename: L
authors.initials: L
authors.lastname: Rozendaal
authors.forename: S
authors.initials: S
authors.lastname: le Cessie
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
authors.forename: R C M
authors.initials: RC
authors.lastname: Hennekam
authors.lastname: The Dutch Marfan Working Group
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006130:Growth Disorders / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000188:drug therapy*; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D015999:Multivariate Analysis; D012044:Regression Analysis; D012189:Retrospective Studies; D013739:Testosterone / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013739:Testosterone; D004997:Ethinyl Estradiol; D008525:Medroxyprogesterone