Tandem oxidation processes using manganese dioxide: discovery, applications, and current studies.
"One-pot" processes in which alcohol oxidations are combined with further elaboration of the carbonyl intermediate are reviewed. Sequential processes are briefly discussed, but most attention is centered on tandem processes; that is, oxidations carried out in the presence of a nucleophilic trapping agent, rather than those in which the trapping agent is added after the oxidation is complete. As part of this Account, a comprehensive review of the discovery of tandem oxidation processes (TOP) will be given together with applications in alkene-forming reactions, cyclopropanations, and imine, oxime, amine, and heterocycle formation.
Taylor
Richard J K
RJ
Department of Chemistry, University of York, Heslington, York YO10 5DD , United Kingdom. rjkt1@york.ac.uk
Reid
Mark
M
Foot
Jonathan
J
Raw
Steven A
SA