Nitric oxide, proteasomal function, and iron homeostasis--implications in aging and neurodegenerative diseases.
In this chapter, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to oxidants. The role of nitric oxide in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications.
Kotamraju
Srigiridhar
S
Department of Biophysics, Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226-0509, USA.
Kalivendi
Shasi
S
Shang
Tiesong
T
Kalyanaraman
B
B
D000375:Aging / Q000502:physiology*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D006706:Homeostasis; D007501:Iron / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D015854:Up-Regulation
D009569:Nitric Oxide; D007501:Iron; D046988:Proteasome Endopeptidase Complex