Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: retrospective cohort study.
OBJECTIVE
To study the long term risk of cervical and other cancers after treatment for cervical intraepithelial neoplasia.


METHODS
Retrospective cohort study.


METHODS
University Hospital, Helsinki, Finland.


METHODS
7564 women treated for cervical intraepithelial neoplasia during 1974 and 2001 and followed up through the Finnish cancer registry until 2003.


METHODS
Standardised incidence ratio for cervical cancer and other cancers.


RESULTS
During follow-up 22 cases of invasive cervical cancer occurred in women treated for cervical intraepithelial neoplasia (standardised incidence ratio 2.8, 95% confidence interval 1.7 to 4.2). The highest risk was during the second decade (10 cases observed: 3.1, 1.5 to 5.7). The standardised incidence ratio for cervical intraepithelial cancer type 1 was 3.1 (1.4 to 6.2) and for type 2 was 3.7 (0.9 to 10.7).


CONCLUSIONS
The risk of cervical cancer in the first 20 years after treatment for cervical intraepithelial neoplasia is higher than in the average population. The risk of smoking related cancers is also increased.
Kalliala
Ilkka
I
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Box 140, FIN-00029, Helsinki, Finland. ilkka.kalliala@helsinki.fi
Anttila
Ahti
A
Pukkala
Eero
E
Nieminen
Pekka
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004812:Epidemiologic Methods; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000209:etiology*; D011230:Precancerous Conditions / Q000453:epidemiology / Q000601:surgery*; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000601:surgery*