[Frequency of mutant lymphocytes in T-cell receptor locus as a possible predictor of thyroid cancer development in irradiated and unirradiated persons].
Was compared frequency of lymphocytes mutant at loci of T-cell receptor (TCR) from samples of peripheral blood taken from 186 healthy donors and 46 untreated thyroid cancer patients, including the persons exposed to ionizing radiation as a result of inhabitation in radioactive polluted region of Russian Federation. Was shown that the cell mutation rate within thyroid cancer group was significantly higher than the same parameter for the healthy person with similar age distribution (p < 0.01). It could be a result of such factors as genotoxic influence, different sensitivity or possible genome instability (including radiation-induced). It was found that 37% of patients have the increased frequency of somatic mutation cells, i.e. it exceeded 95% confidence interval for the screening group. The presented results cause to anticipate that TCR-test could be used as one of criteria for formation groups of high cancer risk development.
Vereshchagina
A O
AO
Zamulaeva
I A
IA
Orlova
N V
NV
Smirnova
S G
SG
Medvedev
V S
VS
Saenko
A S
AS
D000328:Adult; D016022:Case-Control Studies; D042822:Genomic Instability; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*
D011948:Receptors, Antigen, T-Cell