title: A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog.
abstract: Hyperadrenocorticism, a disorder characterized by excessive production of cortisol by the adrenal cortex, is well-recognized in dogs. A 10-year-old, intact male, Yorkshire terrier dog was evaluated because of corneal ulceration and generalized alopecia. Diagnosis was made based on history taking, clinical signs, physical examination, and results of routine laboratory testing (complete blood count, serum biochemical analysis, and urinalysis). In addition, adrenocorticotropic hormone (ACTH) stimulation test and abdominal ultrasonography were also used to diagnose this case. The patient was diagnosed as adrenal gland neoplasia and medical therapy using the adrenocorticolytic agent, mitotane, was initiated. An ACTH stimulation test was performed after initial therapy. After successful induction was obtained, maintenance therapy with mitotane still continued.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Byeong-Teck
authors.initials: BT
authors.lastname: Kang
authors.forename: Dong-in
authors.initials: DI
authors.lastname: Jung
authors.forename: Chul
authors.initials: C
authors.lastname: Park
authors.forename: Ha-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Ju-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Chae-Young
authors.initials: CY
authors.lastname: Lim
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Park
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D008297:Male; D008939:Mitotane / Q000627:therapeutic use*; D011860:Radiography, Abdominal / Q000662:veterinary; D014056:Tomography, X-Ray / Q000662:veterinary
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane; D000324:Adrenocorticotropic Hormone