title: Optimal strategies for newborn ventilation--a synthesis of the evidence.
abstract: A variety of ventilation modes are available for the newborn. Although, there have been randomised trials assessing certain modes, these have generally only included prematurely born infants with RDS or infants with severe respiratory failure. Meta-analysis of the results of those trials has demonstrated that neither patient triggered nor high frequency oscillatory ventilation is advantageous for the prematurely born infant with RDS, but extracorporeal membrane oxygenation increases survival in infants with severe respiratory failure. Appropriately designed studies are required to determine the role of newer ventilation modes and whether forms of respiratory support avoiding intubation are less injurious to the lungs. Research should also focus on infants with other respiratory disorders, particularly BPD. Prior to further randomised trials being undertaken, it is essential that the optimum method of applying each ventilator mode is identified and it is clearly understood whether differences in ventilator/oscillator performance influence outcome.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, King's College London, Children Nationwide Regional Neonatal Intensive Care Centre, 4th floor, Golden Jubilee Wing, King's College Hospital, London, SE5 9PJ, UK. anne.greenough@kcl.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
authors.forename: Atul
authors.initials: A
authors.lastname: Sharma
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000628:therapy*; D006548:Hernia, Diaphragmatic / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D007234:Infant, Premature; D008471:Meconium Aspiration Syndrome / Q000628:therapy*; D011656:Pulmonary Emphysema / Q000628:therapy; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*