[The degradation of p27 and cancer].
The cell cycle of eukaryotic cells is regulated by a series of protein complexes composed of cyclins and cyclin-dependent kinases (CDKs), the activity of which is suppressed by a group of CDK inhibitors (CKIs). Among the CKIs, p27 plays a pivotal role in the control of cell proliferation. Degradation of p27 is a critical event for reentry of cells into the cell cycle from G0 phase and occurs through ubiquitination by two ubiquitin ligase complexes (KPC and SCFSkP2) and subsequent degradation by the 26S-proteasome. A tumor suppressing function of p27 has been demonstrated in mouse models and studies of human tumors. This review will focus on the regulation of p27 proteolysis and its consequences for tumorigenesis.
Kotoshiba
Shuhei
S
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University.
Nakayama
Keiichi
K
D000818:Animals; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D009369:Neoplasms / Q000473:pathology*; D047428:Protein Kinase Inhibitors / Q000378:metabolism*
D047428:Protein Kinase Inhibitors; D050760:Cyclin-Dependent Kinase Inhibitor p27