The immunopharmacological properties of transforming growth factor beta.
Transforming growth factor-beta (TGF-beta) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-betas in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-betas is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.
Le
Yingying
Y
Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P.R. China. yyle@sibs.ac.cn
Yu
Xiaojing
X
Ruan
Lingfei
L
Wang
Oumei
O
Qi
Dongfei
D
Zhu
Jingjing
J
Lu
Xiaofeng
X
Kong
Yan
Y
Cai
Kun
K
Pang
Shanshan
S
Shi
Xianglin
X
Wang
Ji Ming
JM
D000544:Alzheimer Disease / Q000276:immunology / Q000503:physiopathology; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D016212:Transforming Growth Factor beta