Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study.
OBJECTIVE
Zinc Finger Protein 202 (ZNF202) is a transcriptional repressor of genes affecting the vascular endothelium as well as lipid metabolism. A phenotype associated with genetic variation in ZNF202 is presently unknown. We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD).


RESULTS
We conducted a prospective study of more than 9000 individuals from the general population with 24 years follow-up. In women, age-adjusted hazard ratios in heterozygotes and homozygotes versus non-carriers were 1.2 (95% CI: 1.0-1.5, P = 0.04) and 1.5 (1.1-2.1, P = 0.007) for IHD, 1.5 (1.1-2.1; P = 0.01) and 1.7 (1.1-2.8, P = 0.02) for MI, and 1.3 (1.0-1.8, P = 0.07) and 1.3 (0.8-2.1; P = 0.33) for ICVD. Adjustments for lipids and lipoproteins did not alter these hazard ratios substantially. Genotype did not predict risk in men. Finally, results for IHD were borderline significant (P = 0.06) in an independent case-control study including 933 patients and 8068 controls.


CONCLUSIONS
This is the first study to suggest that ZNF202 could be a new candidate gene for IHD and MI in the general population.
Stene
Maria C A
MC
Department of Clinical Biochemistry, KB 3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Dk-2100 Copenhagen Ø, Denmark.
Frikke-Schmidt
Ruth
R
Nordestgaard
Børge G
BG
Steffensen
Rolf
R
Schnohr
Peter
P
Tybjaerg-Hansen
Anne
A
D002352:Carrier Proteins / Q000235:genetics*; D003718:Denmark; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D017202:Myocardial Ischemia / Q000235:genetics*; D012097:Repressor Proteins; D012306:Risk
D002352:Carrier Proteins; D008055:Lipids; D012097:Repressor Proteins; C115745:ZNF202 protein, human