Biomedical aspects of targeted delivery of drugs to pulmonary endothelium.
Drug targeting to selected subcellular compartments of the pulmonary endothelium may optimise treatment of many diseases. This paper describes endothelial determinants that are potentially useful for such targeting, including endothelial ectopeptidases, cell adhesion molecules and novel candidates identified by high-throughput methods, as well as the means to achieve optimal subcellular targeting of drugs in the endothelium that have been explored in cell culture and animal studies. Criteria for determining the applicability for targeting include accessibility, specificity, safety and subcellular precision. The effects of endothelial delivery of therapeutic agents, including the effects mediated by the intervention in the function of the target determinants, must be characterised in the context of given pathological conditions.
Muzykantov
Vladimir R
VR
University of Pennsylvania, Institute for Environmental Medicine and Department of Pharmacology, Philadelphia, 19104-6068, USA. muzykant@mail.med.upenn.edu
D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D001808:Blood Vessels / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems; D004727:Endothelium / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D006801:Humans; D008168:Lung / Q000166:cytology / Q000276:immunology / Q000502:physiology*
D000941:Antigens