Eye development: stable cell fate decisions in insect colour vision.
The retina provides an example of a fundamental property of developing cells: cell fate decisions are stable. A recent paper reports a double negative feedback loop that leads to bistable fate decisions in the colour-detecting photoreceptors of Drosophila.
Freeman
Matthew
M
MRC Laboratory of Molecular Biology, Cambridge, UK. MF1@mrc-lmb.cam.ac.uk
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D003118:Color Perception / Q000502:physiology*; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism; D025461:Feedback, Physiological / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology*; D011494:Protein Kinases / Q000378:metabolism; D012243:Rhodopsin / Q000378:metabolism
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; C505057:melt protein, Drosophila; D012243:Rhodopsin; D011494:Protein Kinases; C093503:wts protein, Drosophila