The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations.
Coexistence of prion disease and idiopathic Parkinson's disease (IPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n = 400). No association between genotypes in codon 129 and IPD was detected in three distinct populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD.
Scholz
Sonja W
SW
Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Building 35, Room 1A-1012, Bethesda, MD 20892, USA. scholzs@mail.nih.gov
Xiromerisiou
Georgia
G
Fung
Hon C
HC
Eerola
Johanna
J
Hellström
Olli
O
Papadimitriou
Alexandros
A
Hadjigeorgiou
Georgios M
GM
Tienari
Pentti J
PJ
Fernandez
Hubert H
HH
Mandel
Ronald
R
Okun
Michael S
MS
Gwinn-Hardy
Katharina
K
Singleton
Andrew B
AB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003062:Codon; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000502:physiology; D017096:Prion Diseases / Q000453:epidemiology* / Q000235:genetics*; D011328:Prions / Q000235:genetics*; D014481:United States / Q000453:epidemiology
D003062:Codon; D011328:Prions