Bipolar radiofrequency induced thermotherapeutic volumetric reduction of VX2 metastases in an animal model.
BACKGROUND
Radiofrequency-induced thermotherapy has shown promising results in the palliative treatment of various tumor entities. The purpose of this study was to investigate the effectiveness of bipolar radiofrequency volumetric tissue reduction (VTR) on lymph node (LN) metastases in the VX2 SCC model.


METHODS
Six male New Zealand white rabbits, with palpable metastatic disease within the parotid lymph nodes, were treated using the Celon-ProSurge probe, needle length 10 mm, diameter of 2.3 mm. The animals were sacrificed on the 4th, 8th, 11th, 14th, 18th and 22nd postoperative days respectively.


CONCLUSIONS
Bipolar radiofrequency VTR could prevent progression of local metastatic disease in one-third of the animals compared to the control group of untreated VX2 carcinoma rabbits. These results encourage further studies, directed at whether this treatment modality could play a role in the palliative therapy of metastatic LN. Future studies should concentrate on the refinement of the treatment parameters and optimization of the treatment duration.
Eivazi
B
B
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Germany.
Sapundhziev
N
N
Folz
B J
BJ
Sesterhenn
A M
AM
Dalchow
C V
CV
Dünne
A A
AA
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D004195:Disease Models, Animal; D004428:Ear Neoplasms / Q000139:chemically induced / Q000473:pathology*; D017097:Electric Impedance; D005069:Evaluation Studies as Topic; D005355:Fibrosis / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects; D008207:Lymphatic Metastasis / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D009336:Necrosis / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology / Q000532:radiotherapy*; D009368:Neoplasm Transplantation; D010307:Parotid Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery; D011817:Rabbits; D021701:Sentinel Lymph Node Biopsy; D013997:Time Factors; D047368:Tumor Burden / Q000528:radiation effects