Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations.
A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.
Newton
Paul N
PN
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. paul@tropmedres.ac
Ward
Steven
S
Angus
Brian J
BJ
Chierakul
Wirongrong
W
Dondorp
Arjen
A
Ruangveerayuth
Ronnatrai
R
Silamut
Kamolrat
K
Teerapong
Pramote
P
Suputtamongkol
Yupin
Y
Looareesuwan
Sornchai
S
White
Nicholas J
NJ
D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011803:Quinine / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013785:Thailand; D017211:Treatment Failure
D000962:Antimalarials; D011803:Quinine