title: In vitro synergy of daptomycin plus rifampin against Enterococcus faecium resistant to both linezolid and vancomycin.
abstract: In vitro synergy testing of daptomycin plus rifampin was performed against 24 unique isolates of Enterococcus faecium resistant to both linezolid and vancomycin. Synergy testing showed that 21/24 (88%) were synergistic and 3/24 (12%) were indifferent by the Etest method. Time-kill assays revealed synergy for 18/24 (75%) and indifference for 6/24 (25%).
authors.affiliation: Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, Louisiana 70121, USA. gpankey@ochsner.org
authors.forename: George
authors.initials: G
authors.lastname: Pankey
authors.forename: Deborah
authors.initials: D
authors.lastname: Ashcraft
authors.forename: Nalini
authors.initials: N
authors.lastname: Patel
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D016984:Enterococcus faecium / Q000187:drug effects*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology*; D020713:Vancomycin Resistance / Q000235:genetics
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid; D017576:Daptomycin; D012293:Rifampin