Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives.
A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652), and antifungal activity against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds 4d and 6a showed very less toxicity against human erythrocytes.
Chaudhary
Preeti
P
Synthetic Organic Chemistry Research Laboratory, Dr.B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.
Kumar
Rupesh
R
Verma
Akhilesh K
AK
Singh
Devender
D
Yadav
Vibha
V
Chhillar
Anil K
AK
Sharma
G L
GL
Chandra
Ramesh
R
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D010879:Piperazines