[Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma].
OBJECTIVE
To detective the relationship between cyclooxygenase-2 (COX-2) and angiogenesis in oral squamous cell carcinoma (OSCC) and its clinical significance through observing the expression of COX-2 and determining microvessel density (MVD) in OSCC.


METHODS
PV-9000 immunohistochemistry was used to determine the expression of COX-2 and CD34, which was used to determine MVD, in 76 OSCC tissues and 12 normal oral mucosa tissues.


RESULTS
Overexpression of COX-2 was detected in OSCC, and was more intense compared with normal epithelium (P < 0.001). The high expression of COX-2 in OSCC was related to neck lymphnode metastasis, tumor size, TNM stage and histological grade (P <0.05). The MVD value in COX-2-positive group was much higher than that in COX-2-negative group (P < 0.01) and that in normal oral mucosa tissues (P < 0.01).


CONCLUSIONS
The high expression of COX-2 in OSCC was significantly associated with MVD, neck lymphnode metastasis, tumor size, TNM stage and histological grade. COX-2 might be one of the important factors in the angiogenesis of OSCC.
Cao
Xuan-ping
XP
Dept. of Oral and Maxillofacial Surgery, College of Stomatology, Zhengzhou University, Zhengzhou 450052, China.
Zhang
Song-tao
ST
Wu
Hao-yang
HY
Liu
Xue-jun
XJ
Zhang
Yuan-yuan
YY
D000328:Adult; D002294:Carcinoma, Squamous Cell; D051546:Cyclooxygenase 2; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms; D009389:Neovascularization, Pathologic
D051546:Cyclooxygenase 2