Translational control by viral proteinases.
Most RNA viruses have evolved strategies to regulate cellular translation in order to promote preferential expression of the viral genome. Positive strand RNA viruses express large portions, or all of their proteome via translation of large polyproteins that are processed by embedded viral proteinases or host proteinases. Several of these viral proteinases are known to interact with host proteins, particularly with the host translation machinery, and thus, encompass the dual functions of processing of viral polyproteins and exerting translation control. Picornaviruses are perhaps the best characterized in regards to interaction of their proteinases with the host translation machinery and will be emphasized here. However, new findings have shown that similar paradigms exist in other viral systems which will be discussed.
Lloyd
Richard E
RE
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. rlloyd@bcm.tmc.edu
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D039603:Eukaryotic Initiation Factor-4G / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism*; D010849:Picornaviridae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D014176:Protein Biosynthesis; D012328:RNA Viruses / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity
D002352:Carrier Proteins; D039603:Eukaryotic Initiation Factor-4G; D010447:Peptide Hydrolases