title: Endoscopic injection of botulinum toxin in the gastric antrum for the treatment of obesity. Results of a pilot study.
abstract: OBJECTIVE
  The aim of this study was to observe the effects of endoscopic injections of botulinum toxin (BT) in the gastric antrum on body weight and gastric emptying in obese patients.
  
  
  METHODS
  Obese patients were selected for the study. By endoscopy, 100 U of BT type A was injected into the prepyloric antral gastric wall. Before and after treatment body weight and solid gastric emptying were evaluated.
  
  
  RESULTS
  Twelve patients were included into this study. Four and twelve weeks after the treatment median values of body weight and gastric emptying did not show significant changes compared to baseline values: body weight: (- 0.5 kg and - 1.0 kg respectively, P > 0.05) and gastric retention for solids at 90 min (+ 4.5% and +10.5% respectively, P > 0.05). Abnormal gastric emptying (solid gastric retention at 90 min > 50%) was observed in 22% of patients after 4 weeks and in 25% after 12 weeks.
  
  
  CONCLUSIONS
  BT injected into the gastric antrum does not seem to significantly reduce body weight or delay gastric emptying in obese patients.
authors.affiliation: Regional Center for the Study of Digestive Diseases, University Hospital. Faculty of Medicine, University Autonomous of Nuevo Leon, Mexico. digarcia@ccr.dsi.uanl.mx
authors.forename: Diego
authors.initials: D
authors.lastname: García-Compean
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mendoza-Fuerte
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Martínez
authors.forename: Irma
authors.initials: I
authors.lastname: Villarreal
authors.forename: Héctor
authors.initials: H
authors.lastname: Maldonado
mesh_terms: D000328:Adult; D001835:Body Weight; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D008297:Male; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D009765:Obesity / Q000188:drug therapy*; D010865:Pilot Projects; D011446:Prospective Studies; D011706:Pyloric Antrum
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A