title: Zinc-mediated ring-expansion and chain-extension reactions of beta-keto esters.
abstract: [Chemical reaction: see text] The reaction of cyclic beta-keto esters with CF3CO2ZnCH2I provided the corresponding ring-expanded products in moderate to good yields. Although alpha-substituted acyclic beta-keto esters reacted with much less efficient, chain-extension reaction of simple beta-keto esters also proceeded effectively to generate gamma-keto esters in high yields.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xuesong@ustc.edu.cn
authors.forename: Song
authors.initials: S
authors.lastname: Xue
authors.forename: Yong-Kang
authors.initials: YK
authors.lastname: Liu
authors.forename: Le-Zhen
authors.initials: LZ
authors.lastname: Li
authors.forename: Qing-Xiang
authors.initials: QX
authors.lastname: Guo
mesh_terms: D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D015032:Zinc
chemical_list: D004952:Esters; D007202:Indicators and Reagents; D007659:Ketones; D015032:Zinc