Near normalisation of lumbar spine bone density in young women with osteopenia recovered from adolescent onset anorexia nervosa: a longitudinal study.
To investigate the effect of the progression of adolescent onset anorexia nervosa (AN) on bone parameters we followed two cohorts (Disease cohort and recovered cohort) of adolescents for a total of 5.2 years. In the 'Disease' cohort (n = 18), lumbar spine bone density (BMD) was reduced by 0.6 SD after 0.8 years of disease and was reduced a further 1.0 SD after a total 2.5 years of disease (p < 0.001). At the third lumbar vertebra there was bone loss (-3.7%, p < 0.05) resulting in reduced volumetric BMD (-5.1%, p < 0.08). In the 'recovered' cohort, lumbar spine BMD was reduced by 1.9 SD after 1.7 years of disease, and increased by 1.5 SD after 2.7 years of recovery (p < 0.001). At the third lumbar vertebra there was an increase in bone mass (20.5%, p < 0.001) and bone volume (14.1%, p < 0.001), resulting in increased volumetric BMD (6.3%, p < 0.08). Normalisation of lumbar spine BMD may be achieved in patients with adolescent onset AN when the successful recovery of body weight is combined with the return of regular menses.
Bass
Shona L
SL
Centre for Physical Activity and Nutrition Research Deakin University 221 Burwood Hwy, Burwood Australia 3125. shona.bass@deakin.edu.au
Saxon
Leanne
L
Corral
Anne-Marie
AM
Rodda
Christine P
CP
Strauss
Boyd J G
BJ
Reidpath
Daniel
D
Clarke
Caroline
C
D000293:Adolescent; D017668:Age of Onset; D000856:Anorexia Nervosa / Q000150:complications / Q000503:physiopathology*; D001835:Body Weight; D015519:Bone Density; D001846:Bone Development; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000503:physiopathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008598:Menstruation; D013131:Spine / Q000503:physiopathology*; D013997:Time Factors