title: Mast cell and immune inhibitory receptors.
abstract: Modulation by balancing activating and inhibitory receptors constitutes an important mechanism for regulating immune responses. Cells that are activated following ligation of receptors bearing immunoreceptor tyrosine-based activation motifs (ITAMs) can be negatively regulated by other receptors bearing immuno-receptor tyrosine-based inhibition motifs (ITIMs). Human mast cells (MCs) are the major effector cells of type I hypersensitivity and important participants in a number of disease processes. Antigen-mediated aggregation of IgE bound to its high-affinity receptor on MCs initiates a complex series of biochemical events leading to MC activation. With great detailed description and analysis of several inhibitory receptors on human MCs, a central paradigm of negative regulation of human MC activation by these receptors has emerged.
authors.affiliation: Tanox, Inc. 10555 Stella link, Houston, Texas 77025, USA.
authors.forename: Lixin
authors.initials: L
authors.lastname: Li
authors.forename: Zhengbin
authors.initials: Z
authors.lastname: Yao
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D006801:Humans; D037102:Lectins / Q000276:immunology; D008407:Mast Cells / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology*; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D015534:Trans-Activators / Q000276:immunology
chemical_list: D000943:Antigens, Differentiation; D037102:Lectins; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D015534:Trans-Activators