[Evaluation on cytotoxicity of a new nano-hydroxyapatite as root canal filling sealer].
OBJECTIVE
To evaluated the cytotoxicity of a new nano-hydroxyapatite (n-HA) root canal sealer.


METHODS
In this study, the cytotoxicity was evaluated by the method of MTT assay in vitro, and culture medium F12 as control, three concentrations of the soaking material cultured with mouse osteoblast separately, to test the cell relative growth rate (RGR) of every group.


RESULTS
The toxicity graduation of the n-HA root canal sealer tends to 0 with the culture time increasing. The cell survival rate of n-HA root canal sealer showed high relatively. The OD value of cell was similar for the negative control and the extracts (P > 0.05).


CONCLUSIONS
The result indicated that n-HA root canal sealer was compatible with the testcells.
Li
Ping
P
Dept. of Endodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Xiao
Li-ying
LY
Li
Wei
W
Tan
Hong
H
Liao
Yun-mao
YM
Yuan
Ming-long
ML
D000818:Animals; D002470:Cell Survival; D003786:Dental Pulp Cavity; D017886:Durapatite; D051379:Mice; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement
D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C112894:canals sealer; D017886:Durapatite