Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities.
Although cytogenetic analysis advanced the understanding of the pathogenesis of primary non-Hodgkin lymphoma and led to improved clinical management, there have been no large cytogenetic studies of post-transplant lymphoproliferative disorder (PTLD). We examined the karyotypes of 36 PTLD cases and correlated them with clinical, laboratory, and pathologic findings. The cases included 2 early lesions, 13 polymorphic PTLDs, and 21 monomorphic PTLDs (18 B-cell and 3 T-cell proliferations). Cytogenetic abnormalities were identified in 72% of monomorphic B-cell PTLDs and in all T-cell PTLDs, but in only 15% of polymorphic PTLDs and in no early lesions. The most frequent clonal abnormalities in monomorphic PTLD were trisomies 9 and/or 11 (5 cases), followed by rearrangements of 8q24.1 (4 cases), 3q27 (2 cases), and 14q32 (2 cases). MYC rearrangement (8q24.1) and T-cell-associated chromosomal abnormalities correlated with poor outcome and short survival. PTLD with trisomy 9 and/or 11 developed early after transplant, presenting as Epstein-Barr virus-positive large B-cell lymphoma with prolonged survival.
Djokic
Miroslav
M
Department of Pathology, University of Chicago Medical Center, 5841 S. Maryland , MC 0008, Illinois 60637, USA.
Le Beau
Michelle M
MM
Swinnen
Lode J
LJ
Smith
Sonali M
SM
Rubin
Charles M
CM
Anastasi
John
J
Carlson
Katrin M
KM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D020031:Epstein-Barr Virus Infections; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000821:virology; D016399:Lymphoma, T-Cell / Q000235:genetics; D008232:Lymphoproliferative Disorders / Q000235:genetics* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000821:virology; D014314:Trisomy