The many roads to cross-presentation.
Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation.
Groothuis
Tom A M
TA
Div. of Tumor Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
Neefjes
Jacques
J
D000818:Animals; D045142:Cross-Priming / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology; D006801:Humans; D010588:Phagosomes / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology