The UMD TP53 database and website: update and revisions.
Mutation of the p53 gene is the most frequent genetic alteration found in human cancer, but it is also the most frequently reported with more than 22,000 mutations published in 2,000 papers. In 1991, we developed a database and software to handle and analyze all this information. The database has been widely used for clinical analysis and molecular epidemiology. We have expanded the scope of the database by integrating structural, phylogenetic and biological information on wild-type (wt) and mutant TP53. Integration of the TP53 mutant activity database provides unique information that will be useful to both clinicians and scientists. All of this information is available from a new website (www.umd.be:2072/) that will generate a detailed informative page for every TP53 mutant in the database. New tools to check TP53 mutations and minimize errors found in the literature are also available.
Hamroun
Dalil
D
Laboratoire de Génétique Moléculaire et Chromosomique, Institut Universitaire de Recherche Clinique et CHU, CNRS UPR 1142, Montpellier, France.
Kato
Shunsuke
S
Ishioka
Chikashi
C
Claustres
Mireille
M
Béroud
Christophe
C
Soussi
Thierry
T
D004252:DNA Mutational Analysis; D030541:Databases, Genetic; D006801:Humans; D020407:Internet; D009154:Mutation / Q000235:genetics*; D010802:Phylogeny; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics*
D016159:Tumor Suppressor Protein p53