Microdialysis of the bowel: the possibility of monitoring intestinal ischemia.
Assessment of the intestinal circulation in a clinical setting still presents a significant diagnostic challenge. In patients suspected of having intestinal ischemia pre- or postoperatively, there is no clinically relevant marker which can determine whether the bowel is suffering from lack of oxygen or not. Microdialysis is a microinvasive technique that makes it possible to continuously detect tissue-specific metabolic changes. Recently, it has been demonstrated that intestinal ischemia can be detected and monitored continuously by the use of a microdialysis catheter placed in the proximity of the ischemic bowel. This review summarizes the clinical dilemma of intestinal ischemia and the latest experimental results using the microdialysis technique to detect critical perfusion in the small intestine. The possibility of using microdialysis in a clinical setting is outlined with the perspective of using it as a pre- or postoperative monitoring tool in relevant patients.
Sommer
Thorbjørn
T
Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg DK-9000, Denmark. sommers@privat.dk
D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000175:diagnosis*; D017551:Microdialysis / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D013673:Technology Assessment, Biomedical; D016896:Treatment Outcome