Patterns of linkage disequilibrium in the type 2 diabetes gene calpain-10.
We investigated the patterns and extent of linkage disequilibrium (LD) in the vicinity of the type 2 diabetes gene calapin-10 (CAPN10) in Mexican Americans, European Americans, African Americans, and Chinese Americans. We found that CAPN10 occurs within a single block of high LD and that LD decays rapidly outside of the gene. This reduces the likelihood that associations between CAPN10 polymorphisms and type 2 diabetes could be attributed to variation at some distance from CAPN10. We also consistently observed that cases have more extensive LD than control subjects and that cases from families with evidence for linkage have more extensive LD than cases from families without evidence for linkage. These observations further suggest that there are one or more relatively common alleles increasing risk of type 2 diabetes in this local region.
Hayes
M Geoffrey
MG
Department of Human Genetics, University of Chicago, 920 E. 58th St., CLSC 507, Chicago, Illinois 60637, USA.
del Bosque-Plata
Laura
L
Tsuchiya
Takafumi
T
Hanis
Craig L
CL
Bell
Graeme I
GI
Cox
Nancy J
NJ
D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D044469:Racial Groups / Q000235:genetics; D012307:Risk Factors
D002154:Calpain; C415197:calpain 10