A simple model for quantification of the radiobiological effectiveness of the 10B(n,alpha)7Li capture reaction in BNCT.
A simple model has been developed for predicting radiobiological effectiveness of the neutron capture reaction in boron neutron capture therapy. This model was derived from the relationship between the cell survival from the boron capture reaction, the intracellular boron concentration, and the thermal neutron fluence. We found that the cell-killing effect of the boron capture reaction was well described using a power function of the intracellular boron concentration. Hence the relationship between cell survival from the boron capture reaction, intracellular boron concentration, and the thermal neutron fluence could be determined using a simple mathematical equation. We consider that our current approach is more appropriate and realistic than the conventional theoretical mathematical model used to estimate the radiobiological effectiveness of the neutron capture reaction in boron neutron capture therapy.
Hsieh
C H
CH
Department of Medical Radiation Technology and Institute of Radiological Sciences, National Yang-Ming University, 155 Li-Nong St., Sec.2, Peitou, Taipei, Taiwan.
Liu
H M
HM
Hwang
J J
JJ
Wang
H E
HE
Kai
J J
JJ
Chen
F D
FD
D000818:Animals; D001895:Boron / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology*; D007554:Isotopes / Q000627:therapeutic use; D008094:Lithium / Q000627:therapeutic use*; D008954:Models, Biological; D011859:Radiography; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D012062:Relative Biological Effectiveness
D007554:Isotopes; D008094:Lithium; D001895:Boron