title: The KCNQ1 potassium channel: from gene to physiological function.
abstract: The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.
authors.affiliation: Department of Medical Physiology, University of Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Jespersen
authors.forename: Morten
authors.initials: M
authors.lastname: Grunnet
authors.forename: Søren-Peter
authors.initials: SP
authors.lastname: Olesen
mesh_terms: D000818:Animals; D004594:Electrophysiology; D004848:Epithelium / Q000502:physiology; D006321:Heart / Q000502:physiology; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics / Q000502:physiology*
chemical_list: D051657:KCNQ1 Potassium Channel