External inferior colliculus integrates trigeminal and acoustic information: unit responses to trigeminal nucleus and acoustic stimulation in the guinea pig.
The external nucleus of the inferior colliculus (ICx) receives ascending projections from both auditory and somatosensory nuclei. In the guinea pig, both the spinal trigeminal nucleus (TN) and the cochlear nucleus converge in the ventrolateral region of ICx. We investigated the function of trigeminal-collicular pathways by electrically stimulating the TN while recording unit responses from ICx. Pairing electrical stimulation with acoustic stimuli allowed us to investigate the function of converging auditory and somatosensory inputs, i.e. multisensory integration. Unit responses were recorded from ICx using a multi channel, single shank electrode. Electrical stimulation of the TN produced small changes above or below spontaneous rate, but resulted in significant suppression or enhancement of sound-evoked responses. Multisensory integration has been demonstrated in the dorsal cochlear nucleus (DCN), superior colliculus and sensory cortices and may play a role in plasticity that occurs after sensory deprivation.
Jain
Roshini
R
Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA.
Shore
Susan
S
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D007245:Inferior Colliculi / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D014278:Trigeminal Nuclei / Q000502:physiology*