title: Alleviative effects of gamma-aminobutyric acid (GABA) on behavioral abnormalities in aged dogs.
abstract: gamma-aminobutyric acid (GABA, 30 mg/kg) was administered to aged dogs with recent history of veterinary clinic visits (mean age: 15.3 years old) once daily for 2 weeks by mixing with food. Their owners subjectively evaluated the effects of GABA on behavioral signs often associated with aging in the dogs. Improvement in some of behavioral signs was notable without any observable adverse effects. Dogs administered with GABA tended to exhibit improvement in emotional states and signs may be caused by neurovegetable dysfunction, though effects on cognitive dysfunction syndrome were not always observed. Thus, GABA administration may be one of the effective means of improving the quality of life of aged dogs.
authors.affiliation: Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Inagawa
authors.forename: Shinobu
authors.initials: S
authors.lastname: Seki
authors.forename: Makoto
authors.initials: M
authors.lastname: Bannai
authors.forename: Yukari
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mori
authors.forename: Michio
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000375:Aging; D000818:Animals; D001526:Behavioral Symptoms / Q000188:drug therapy*; D004285:Dogs; D011788:Quality of Life; D011795:Surveys and Questionnaires; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D005680:gamma-Aminobutyric Acid