A novel cause of invasive pulmonary infection in an immunocompetent patient: Aspergillus candidus.
Aspergillus candidus, a common contaminant of grain dust, may represent an important respiratory hazard to grain workers, considering its immunomodulating capability by producing p-terphenyl metabolites and terprenins, potent cytotoxic substances. However, there are only three cases of A. candidus infection in the English literature, one fatal solitary brain mass and two onychomycosis. We describe the first case of invasive pulmonary infection and skin abscesses due to A. candidus, determination of minimal inhibitory concentration for anti-fungals, and the successful treatment with liposomal amphotericin B and itraconazole. Possible mechanisms involved in the dissemination of infection in an immunocompetent host are discussed.
Ribeiro
S C C
SC
Pulmonary Division, University of São Paulo Medical School, São Paulo, SP, Brazil.
Santana
A N C
AN
Arriagada
G H
GH
Martins
J E C
JE
Takagaki
T Y
TY
D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D001230:Aspergillus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D044963:Biopsy, Fine-Needle; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007121:Immunocompetence; D017964:Itraconazole / Q000008:administration & dosage; D008081:Liposomes; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008875:Middle Aged; D013902:Radiography, Thoracic; D016896:Treatment Outcome
D000935:Antifungal Agents; D008081:Liposomes; D017964:Itraconazole; D000666:Amphotericin B