title: Solid-phase synthesis of 2-aminoquinazolinone derivatives with two- and three-point diversity.
abstract: A versatile solid-phase method for the synthesis of various substituted 2-amino-4(3H)-quinazolinones with two- and three-point diversity is described. The synthesis commenced with the generation of polymer-bound S-methylisothiourea followed by N-acylation with different substituted o-nitrobenzoic acid. Finally, reduction of the nitro group triggered intramolecular cyclization via formation of guanidine to afford 2-amino-4(3H)-quinazolinone and its derivatives in high yields and purities.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India. bijoy_kundu@yahoo.com
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu
authors.forename: Pankaj
authors.initials: P
authors.lastname: Partani
authors.forename: Srinivas
authors.initials: S
authors.lastname: Duggineni
authors.forename: Devesh
authors.initials: D
authors.lastname: Sawant