title: Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats.
abstract: Momordica charantia and Andrographis paniculata are the commonly used herbs by the diabetic patients in Pampanga, Philippines. While the anti-diabetic potential of Momordica charantia is well established in streptozocin- or alloxan-induced diabetic animals, the anti-diabetic potential of Andrographis paniculata in alloxan-induced diabetic rat is not known. Neither the effects of these herbs on estrous cyclicity of alloxan-induced diabetic rats are elucidated. Thus, in these experiments, Momordica charantia fruit juice or Andrographis paniculata decoction was orally administered to alloxan-induced diabetic rats. Rats that were treated with Momordica charantia and Andrographis paniculata had higher body weight (BW) compared with diabetic positive control (P < 0.01) from day 22 to day 27 (D27) but exhibited lower BW than the non-diabetic control (P < 0.05). These rats had lower feed (P < 0.05) and liquid intakes (P < 0.01) compared with diabetic positive control from day 17 to D27, but similar with the non-diabetic control. The blood glucose levels in these groups were significantly reduced from day 12 to D27 compared with diabetic positive control (P < 0.01), however, comparable with non-diabetic control. The diabetic positive control had extended mean estrous cycles (8 days) compared to Momordica charantia and Andrographis paniculata-treated diabetic rats (5 days; P < 0.05). Our results suggest that the anti-diabetic potentials of Momordica charantia and Andrographis paniculata could restore impaired estrous cycle in alloxan-induced diabetic rats.
authors.affiliation: Thomas Jefferson University, Department of Neurosurgery, Farber Institute for Neurosciences, Philadelphia, Pennsylvania 19107, USA. bsr103@jefferson.edu
authors.forename: B A S
authors.initials: BA
authors.lastname: Reyes
authors.forename: N D
authors.initials: ND
authors.lastname: Bautista
authors.forename: N C
authors.initials: NC
authors.lastname: Tanquilut
authors.forename: R V
authors.initials: RV
authors.lastname: Anunciado
authors.forename: A B
authors.initials: AB
authors.lastname: Leung
authors.forename: G C
authors.initials: GC
authors.lastname: Sanchez
authors.forename: R L
authors.initials: RL
authors.lastname: Magtoto
authors.forename: P
authors.initials: P
authors.lastname: Castronuevo
authors.forename: H
authors.initials: H
authors.lastname: Tsukamura
authors.forename: K-I
authors.initials: KI
authors.lastname: Maeda
mesh_terms: D000496:Alloxan; D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006029:Glycosuria / Q000652:urine; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D029775:Momordica / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan