Factors that regulate naturally occurring T regulatory cell-mediated suppression.
T regulatory (Treg) cells play a key role in the modulation of allergic and autoimmune responses. This review will discuss the factors that regulate naturally occurring Treg (nTreg) cell-mediated suppression. The involvement of cytokines, costimulatory molecules, and ligands on antigen-presenting cells in the inhibition of nTreg cell-mediated suppression in vitro is summarized. Understanding the events that control suppressive function of nTreg cells will allow manipulation of these cells to inhibit or enhance their functions in the development of novel therapies for autoimmune and allergic diseases.
Goleva
Elena
E
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
Cardona
Ivan D
ID
Ou
Liang-Shiou
LS
Leung
Donald Y M
DY
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000818:Animals; D000941:Antigens / Q000502:physiology; D018407:Bacterial Physiological Phenomena; D018106:CD28 Antigens / Q000502:physiology; D051858:Forkhead Transcription Factors; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology*; D007376:Interleukin-2; D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000502:physiology*; D018406:Virus Physiological Phenomena
D000305:Adrenal Cortex Hormones; D000941:Antigens; D018106:CD28 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007376:Interleukin-2; D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor