title: IL4 receptor polymorphism is associated with increased risk of sudden deafness in Korean population.
abstract: The interleukin 4 receptor (IL4R) polymorphism Q576R (rs 180275) has been well known to be associated with atopy and other inflammatory diseases. A single nucleotide polymorphism (SNP) A > G transition potentiates the binding specificity of the adjacent tyrosine residue. In this study we investigated the possible relationship between sudden deafness (SD) and IL4R polymorphism Q576R in 97 Korean SD patients and 613 controls using pyrosequencing method. The odds ratio (OR) for SD associated with the G vs. A allele was 2.58 [P < 0.0001, 95% confidence interval (CI) = 1.84-3.60]. We then sub-grouped SD into Tinnitus positive (+) and Tinnitus negative (-). G allele in Tinnitus (+) is significantly associated with the development of Tinnitus (+) [X(2) = 32.02, P < 0.0001, OR (95% CI) = 2.74 (1.91-3.93)] but not with Tinnitus (-). Taken together these results suggest that G allele could be a risk factor for SD.
authors.affiliation: Department of Otolaryngology, School of Medicine, Keimyung University, Daegu, Republic of Korea.
authors.forename: Sung Il
authors.initials: SI
authors.lastname: Nam
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Ha
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Jung
authors.forename: Hyung Hwan
authors.initials: HH
authors.lastname: Baik
authors.forename: Seo Hyun
authors.initials: SH
authors.lastname: Yoon
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Bong-Keun
authors.initials: BK
authors.lastname: Choe
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Jung-Chul
authors.initials: JC
authors.lastname: Seo
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Bae
authors.forename: Min
authors.initials: M
authors.lastname: Nam
authors.forename: In-Jang
authors.initials: IJ
authors.lastname: Choi
authors.forename: Joong-Gahng
authors.initials: JG
authors.lastname: Kim
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
mesh_terms: D005260:Female; D003639:Hearing Loss, Sudden / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012307:Risk Factors
chemical_list: D019948:Receptors, Interleukin-4