title: Posttransplant lymphoproliferative disorder in a lung transplant recipient.
abstract: The authors describe a case of posttransplant lymphoproliferative disorder (PTLD) in a 38-year-old Japanese male patient who had undergone bilateral lung transplantation. Chest CT performed on day 109 revealed multiple lung nodules measuring approximately 1cm in the left lower lobe. Despite administration of anti-fungal agents, follow-up CT performed on day 138 showed bilateral lung nodules increased in size and number. Transcutaneous lung biopsy was performed, yielding a diagnosis of polymorphic PTLD positive for Epstein-Barr virus (EBV)-encoded RNA (EBER) and CD20. Treatment with rituximab was successful, resulting in decreased size and number of lung nodules. FDG-PET showed no increased metabolic activity in the residual nodules. In this case, CT and FDG-PET were useful for initial diagnosis and evaluation of treatment response. To the best of our knowledge, this is the first report of PTLD in a lung transplant recipient in Japan documented in the English literature.
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. tamai@kuhp.kyoto-u.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Tamai
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyama
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Saga
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Umeoka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Aoyama
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Hanaoka
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Fukuse
authors.forename: Hiromi
authors.initials: H
authors.lastname: Wada
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tachibana
authors.forename: Kaori
authors.initials: K
authors.lastname: Togashi
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20 / Q000032:analysis; D001706:Biopsy; D020031:Epstein-Barr Virus Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016040:Lung Transplantation; D008232:Lymphoproliferative Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D019275:Radiopharmaceuticals; D000069283:Rituximab; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D000069283:Rituximab