title: Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.
abstract: We show the separation of metal radioisotope impurities using capillary electrophoresis (CE). The methodology used is an improvement of existent protocols for separation of stable metal ions. Production of fluorine-18 using [(18)O]H(2)O-enriched water encased in a titanium target body results in the production of several metal radioisotope impurities. Optimisation of the conditions for CE separation of the metal radioisotope impurities incorporated the use of 6 mM 18-Crown-6 in combination with 12 mM glycolic acid as complexing agents within the running buffer (10 mM pyridine, pH 4.0). Using this optimised procedure, we were able to separate and detect a number of metal radioisotopes, including chromium, cobalt, manganese, vanadium and berillium, within the fM concentration range.
authors.affiliation: Cancer Research-UK/UMIST Radiochemical Targeting and Imaging Group, Christie Hospital NHS Trust, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK. jgillies@picr.man.ac.uk
authors.forename: J M
authors.initials: JM
authors.lastname: Gillies
authors.forename: N
authors.initials: N
authors.lastname: Najim
authors.forename: J
authors.initials: J
authors.lastname: Zweit
mesh_terms: D017357:Cyclotrons; D019075:Electrophoresis, Capillary; D005462:Fluorine Radioisotopes; D008670:Metals / Q000032:analysis*; D010103:Oxygen Isotopes; D014867:Water / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D008670:Metals; D010103:Oxygen Isotopes; D014867:Water