title: Improved methodologies for the preparation of highly substituted pyridines.
abstract: [reaction: see text] Two separate strategies have been developed for the preparation of highly substituted pyridines from 1,2,4-triazines via the inverse-electron-demand Diels-Alder reaction: a microwave-promoted, solvent-free procedure and a tethered imine-enamine (TIE) approach. Both routes avoid the need for a discrete aromatization step and offer significant advantages over the classical methods, giving a wide variety of tri-, tetra-, and penta-substituted pyridines in high, optimized yields.
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Fernández Sainz
authors.forename: Steven A
authors.initials: SA
authors.lastname: Raw
authors.forename: Richard J K
authors.initials: RJ
authors.lastname: Taylor
mesh_terms: D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011725:Pyridines