Anaemia after renal transplantation.
Anaemia is a frequent complication among long-term renal transplant recipients. A prevalence of approximately 40% has been reported in several studies. If renal function declines to stage 5 kidney disease, the prevalence of anaemia in kidney transplants is even higher. A positive correlation between haemoglobin concentration and creatinine clearance has been reported, which is a function of endogenous erythropoietin production by the functioning graft. Inflammation related to a retained kidney graft may cause hypo-responsiveness to erythropoietic agents once kidney transplant recipients return to dialysis. Furthermore, the use of azathioprine, mycophenolate mofetil and sirolimus may be associated with post-transplant anaemia. Along with erythropoietin deficiency, depletion of iron stores is one of the major reasons for anaemia in the kidney transplant population. The proportion of hypochromic red blood cells appears to be a useful parameter to measure iron supply and utilization as well as to estimate mortality risks in kidney transplant recipients. While anaemia is an important cardiovascular risk-factor after transplantation, our data suggest that anaemia is not associated with mortality and graft loss. Nevertheless, inadequate attention is paid so far to the management of anaemia after renal transplantation. A promising future aspect for risk reduction of cardiovascular disease includes the effect of erythropoietic agents on endothelial progenitor cells.
Lorenz
M
M
Department of Medicine III, Medical University of Vienna, Vienna, Austria, and Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, USA. matthias.lorenz@meduniwien.ac.at
Winkelmayer
W C
WC
Hörl
W H
WH
Sunder-Plassmann
G
G
D000740:Anemia / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000209:etiology; D042783:Endothelial Cells / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology; D004920:Erythropoiesis / Q000502:physiology; D006084:Graft Rejection / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D000090463:Iron Deficiencies; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors; D013234:Stem Cells / Q000502:physiology; D014168:Transferrin / Q000378:metabolism
D007166:Immunosuppressive Agents; D014168:Transferrin