Expression of capsaicin receptor TRPV-1 in synovial tissues of patients with symptomatic internal derangement of the temporomandibular joint and joint pain.
OBJECTIVE
To elucidate expression of capsaicin receptor TRPV-1 in synovial tissues of the human temporomandibular joint (TMJ) with internal derangement and discuss its relationship with joint pain.


METHODS
Fifty-four TMJs in 54 patients were examined using an immunohistochemical technique. As controls, 10 TMJs with habitual dislocation without pain were also examined.


RESULTS
TRPV-1 was expressed mainly in the blood vessels beneath the lining cells in synovial tissues from 31 of the 54 joints with internal derangement and from 8 of the 10 control joints. The extent score of TRPV-1-stained cells with internal derangement was not significantly higher than that of controls. The extent score of TRPV-1 showed no correlation with joint pain.


CONCLUSIONS
TRPV-1 was detected in the region of the posterior disk attachment of synovial tissues from the TMJ in patients with internal derangement and controls. TRPV-1 may play a role in maintenance of the physiologic condition of the TMJ.
Sato
Jun
J
Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa, Japan. jun-s@kanazawa-med.ac.jp
Segami
Natsuki
N
Yoshitake
Yoshino
Y
Kaneyama
Keiseki
K
Abe
Atsuko
A
Yoshimura
Hiroshi
H
Fujimura
Kazuma
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000378:metabolism; D016022:Case-Control Studies; D005157:Facial Pain / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D004204:Joint Dislocations / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000098:blood supply / Q000737:chemistry / Q000378:metabolism*; D013585:Synovitis / Q000378:metabolism; D050916:TRPV Cation Channels / Q000032:analysis / Q000096:biosynthesis*; D013704:Temporomandibular Joint / Q000378:metabolism*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*
D050916:TRPV Cation Channels; C494482:TRPV1 protein, human