title: Inverse correlation between coronary blood flow velocity and sICAM-1 level observed in ischemic heart disease patients.
abstract: Systemic factors and blood flow velocity related to atherosclerosis have been examined mainly separately or by in vitro studies. The aim of our study was to investigate the association between local coronary blood flow (corrected TIMI frame count, CTFC) and systemic atherosclerosis-related inflammatory parameters such as soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (Il-6), high sensitivity C-reactive protein (hsCRP) and von Willebrand factor (vWF) in humans. We enrolled the following groups of ischemic heart disease (IHD) patients: patients with coronary stenosis and stable (CAD, n = 96) or unstable angina (ACS, n = 27), patients with documented myocardial ischemia and normal coronary angiogram (NEG, n = 68). Patient groups showed only marginal differences in CTFC or sICAM-1 levels. In contrast, when IHD patients were studied individually, general positive correlation was found between CTFC and sICAM-1 level (r = 0.33; in NEG r = 0.25; in CAD r = 0.37; in ACS r = 0.61), being the strongest in ACS. The relation was independent from age, gender, BMI, smoking, hypertension, diabetes, previous myocardial infarction, family history of IHD, medication, hsCRP, IL-6 and vWF levels. (odds ratio, OR = 6.4; CI 95%: 2.43-16.84; p < 0.05). Nevertheless, correlation between CTFC and IL-6, hsCRP, vWF levels was not found. These results indicate inverse correlation between coronary blood flow and adhesion molecule production independently from conventional cardiovascular risk factors and inflammatory markers.
authors.affiliation: Cardiovascular Research Group, Hungarian Academy of Sciences and Semmelweis University and National Health Center, Budapest, Hungary.
authors.forename: Jusztina
authors.initials: J
authors.lastname: Bencze
authors.forename: Robert Gabor
authors.initials: RG
authors.lastname: Kiss
authors.forename: Emese
authors.initials: E
authors.lastname: Toth-Zsamboki
authors.forename: Katarina
authors.initials: K
authors.lastname: Vargova
authors.forename: Gabor
authors.initials: G
authors.lastname: Kerecsen
authors.forename: Andras
authors.initials: A
authors.lastname: Korda
authors.forename: Ferenc
authors.initials: F
authors.lastname: Molnar
authors.forename: Istvan
authors.initials: I
authors.lastname: Preda
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D003326:Coronary Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D015850:Interleukin-6; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein