CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.
There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF beta-amyloid(1-42) (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF Abeta42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.
Brew
B J
BJ
Department of Neurology, St. Vincent's Hospital, University of New South Wales, Sydney, Australia. b.brew@unsw.edu.au
Pemberton
L
L
Blennow
K
K
Wallin
A
A
Hagberg
L
L
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000821:virology; D000328:Adult; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism / Q000503:physiopathology / Q000821:virology; D005260:Female; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000134:cerebrospinal fluid; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D012016:Reference Values; D019562:Viral Load; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; D012367:RNA, Viral; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D019798:Neopterin