title: A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides.
abstract: [reaction: see text] CuI-catalyzed N-arylation of imidazoles with aryl bromides has been achieved in a near-homogeneous system that utilizes tetraethylammonium carbonate as base, 8-hydroxyquinoline as ligand, and H2O as cosolvent. Preliminary results with aryl chlorides are also reported.
authors.affiliation: Chemical Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. lliu@amgen.com
authors.forename: Longbin
authors.initials: L
authors.lastname: Liu
authors.forename: Mike
authors.initials: M
authors.lastname: Frohn
authors.forename: Ning
authors.initials: N
authors.lastname: Xi
authors.forename: Celia
authors.initials: C
authors.lastname: Dominguez
authors.forename: Randy
authors.initials: R
authors.lastname: Hungate
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Reider
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012995:Solubility; D013237:Stereoisomerism
chemical_list: D006846:Hydrocarbons, Halogenated; D007093:Imidazoles; D003300:Copper