IL4 receptor polymorphism is associated with increased risk of sudden deafness in Korean population.
The interleukin 4 receptor (IL4R) polymorphism Q576R (rs 180275) has been well known to be associated with atopy and other inflammatory diseases. A single nucleotide polymorphism (SNP) A > G transition potentiates the binding specificity of the adjacent tyrosine residue. In this study we investigated the possible relationship between sudden deafness (SD) and IL4R polymorphism Q576R in 97 Korean SD patients and 613 controls using pyrosequencing method. The odds ratio (OR) for SD associated with the G vs. A allele was 2.58 [P < 0.0001, 95% confidence interval (CI) = 1.84-3.60]. We then sub-grouped SD into Tinnitus positive (+) and Tinnitus negative (-). G allele in Tinnitus (+) is significantly associated with the development of Tinnitus (+) [X(2) = 32.02, P < 0.0001, OR (95% CI) = 2.74 (1.91-3.93)] but not with Tinnitus (-). Taken together these results suggest that G allele could be a risk factor for SD.
Nam
Sung Il
SI
Department of Otolaryngology, School of Medicine, Keimyung University, Daegu, Republic of Korea.
Ha
Eunyoung
E
Jung
Kyung Hee
KH
Baik
Hyung Hwan
HH
Yoon
Seo Hyun
SH
Park
Hae Jeong
HJ
Choe
Bong-Keun
BK
Chung
Joo-Ho
JH
Seo
Jung-Chul
JC
Lee
Mi Young
MY
Bae
Jae-Hoon
JH
Nam
Min
M
Choi
In-Jang
IJ
Kim
Joong-Gahng
JG
Shin
Dong-Hoon
DH
D005260:Female; D003639:Hearing Loss, Sudden / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012307:Risk Factors
D019948:Receptors, Interleukin-4