Acid acclimation by Helicobacter pylori.
Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
Sachs
George
G
Laboratory of Membrane Biology, David Geffen School of Medicine at the University of California-Los Angeles, USA. gsachs@ucla.edu
Weeks
David L
DL
Wen
Yi
Y
Marcus
Elizabeth A
EA
Scott
David R
DR
Melchers
Klaus
K
D000222:Adaptation, Physiological; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D014510:Urease / Q000378:metabolism
D014510:Urease