Krebs cycle anions in metabolic acidosis.
For many years it has been apparent from estimates of the anion gap and the strong ion gap that anions of unknown identity can be generated in sepsis and shock states. Evidence is emerging that at least some of these are intermediates of the citric acid cycle. The exact source of this disturbance remains unclear, because a great many metabolic blocks and bottlenecks can disturb the anaplerotic and cataplerotic pathways that enter and leave the cycle. These mechanisms require clarification with the use of tools such as gas chromatography-mass spectrometry.
Bowling
Francis G
FG
Mater Children's Hospital, Australia. frank.bowling@mater.org.au
Morgan
Thomas J
TJ
D000136:Acid-Base Equilibrium / Q000502:physiology*; D000138:Acidosis / Q000209:etiology / Q000378:metabolism*; D000429:Alcohol Oxidoreductases / Q000097:blood; D000838:Anions / Q000378:metabolism*; D002952:Citric Acid Cycle / Q000502:physiology*; D008401:Gas Chromatography-Mass Spectrometry; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D006801:Humans; D018805:Sepsis; D012769:Shock
D000838:Anions; D000429:Alcohol Oxidoreductases; C031416:D-lactaldehyde dehydrogenase; D005969:Glutamate Dehydrogenase; D005974:Glutamate-Ammonia Ligase