title: [Neurogenic inflammation and chronic rhinosinusitis].
abstract: The nasal mucosa is one of the anatomical region which have the highest density of sensory innervation. The function of this sensory innervation is probably linked to the protection of the lower airways against inhalation of airborne particles and potentially harmful substances. Chronic rhinosinusitis (CRS) is associated with nasal obstruction, rhinorrhea, loss of sense of smell and facial pain or headaches. When allergy or specific hyperreactivity, infection, systemic or genetic deseases have been excluded, the diagnosis of non specific hyperreactivity or neurogenic inflammation is proposed. Sensory neuropeptides released by sensory nerves endings have powerful proinflammatory effects. The best treatment yet available include nasal lavages and the local application of topical corticosteroid spray.
authors.affiliation: Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, Unité de rhinologie-olfactologie, HUG, Genève. silvain.lacroix@hcuge.ch
authors.forename: J S
authors.initials: JS
authors.lastname: Lacroix
authors.forename: A
authors.initials: A
authors.lastname: Ricchetti Coignard
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009297:Nasal Mucosa / Q000294:innervation*; D009475:Neurons, Afferent / Q000276:immunology / Q000473:pathology; D012220:Rhinitis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology*; D012852:Sinusitis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology*
chemical_list: D000305:Adrenal Cortex Hormones