Patterns of nestin expression in human skin.
Nestin, a member of the sixth class of intermediate filament proteins, has long been known not only as a specific marker for central nervous system stem cells, but also as an indicator of the degree of neural stem cell differentiation. Immunohistochemical analysis showed nestin expression in the epidermis and the upper two-third of the hair follicle in non-balding human scalp skin, but not in the lower third of the follicle. Expression was very weak in the sebaceous gland. The level of nestin mRNA transcription was much higher in the bulge region of the follicle than in the sebaceous gland. These results show that the pattern of nestin expression is related to the differentiation of epidermal stem cells.
Wang
Yun
Y
Department of Cell Biology, The Third Military Medical University, Chong Qing 400038, PR China.
Zhang
Yi
Y
Zeng
Yijun
Y
Zheng
Yehua
Y
Fu
Gang
G
Cui
Zhihong
Z
Yang
Tian
T
D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism; D005786:Gene Expression Regulation; D018859:Hair Follicle / Q000166:cytology / Q000378:metabolism; D006416:Hematoxylin; D006801:Humans; D007074:Immunoglobulin G; D007381:Intermediate Filament Proteins / Q000235:genetics* / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D064231:Nestin; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012627:Sebaceous Glands / Q000166:cytology / Q000378:metabolism; D012867:Skin / Q000378:metabolism*
D007074:Immunoglobulin G; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; D012333:RNA, Messenger; D006416:Hematoxylin