title: Spectral derivative based image reconstruction provides inherent insensitivity to coupling and geometric errors.
abstract: A reconstruction algorithm for multiwavelength diffuse optical tomography is presented, where instead of using data at each wavelength separately or even simultaneously, the difference in data for multiple wavelength pairs is used to reconstruct absolute concentration maps of chromophores. The results indicate a dramatic improvement in image reconstruction and the elimination of image artifacts, which are often associated with unknown measurement errors such as coupling coefficients and external boundary variations, because these errors are often less dependent on wavelength, and are effectively removed from the data set of the first derivative of intensity with respect to wavelength.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA. Heng.Xu.th05@alum.dartmouth.edu
authors.forename: Heng
authors.initials: H
authors.lastname: Xu
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.forename: Roger
authors.initials: R
authors.lastname: Springett
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
mesh_terms: D000465:Algorithms; D016477:Artifacts; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*