A stereochemically well-defined rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones.
[reaction: see text] A rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones has been designed. The incorporation of a tethering group between the diamino group and the cyclopentadienyl unit provides extra stereochemical rigidity. The catalyst is capable of enantioselective reduction of a range of ketones in excellent ee using formic acid/triethylamine as both the solvent and the reducing agent.
Matharu
Daljit S
DS
Asymmetric Catalysis Group, Department of Chemistry, University of Warwick, Coventry, UK.
Morris
David J
DJ
Kawamoto
Aparecida M
AM
Clarkson
Guy J
GJ
Wills
Martin
M