title: Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin.
abstract: OBJECTIVE
  Newborn cells may participate in repair following ischemic brain injury, but their survival and function may be influenced by inflammation.
  
  
  METHODS
  We investigated the effects of indomethacin, a nonsteroidal antiinflammatory drug, on the fate of newborn cells following transient focal ischemia.
  
  
  RESULTS
  Bromodeoxyuridine (BrdU)-labeled cells, including migrating neuroblasts, were observed in the neighboring striatum and overlying cortex 1 day poststroke. The density of BrdU+ cells labeled with doublecortin, nestin, glial fibrillary acidic protein, or NG2 was increased at 14 and 28 days. Indomethacin increased BrdU+ cells of all lineages and reduced microglial/monocyte activation.
  
  
  CONCLUSIONS
  Indomethacin enhanced the accumulation of newborn cells following stroke.
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, CA, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Hoehn
authors.forename: Theo D
authors.initials: TD
authors.lastname: Palmer
authors.forename: Gary K
authors.initials: GK
authors.lastname: Steinberg
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D019070:Cell Lineage / Q000187:drug effects; D002540:Cerebral Cortex / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology; D000089662:Doublecortin Protein; D007155:Immunologic Factors / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology; D002546:Ischemic Attack, Transient / Q000473:pathology* / Q000503:physiopathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D017628:Microglia / Q000187:drug effects / Q000473:pathology; D009000:Monocytes; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; C000714848:Dcx protein, rat; D000089662:Doublecortin Protein; D007155:Immunologic Factors; D007213:Indomethacin