Diffuse optical measurement of blood flow in breast tumors.
Blood flow contrast between tumor and normal tissues in patients with malignant and benign breast cancer was measured by diffuse optical correlation methods. The measurements were carried out with a hand-held optical probe that was manually scanned over the tumor-bearing breast. Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography.
Durduran
Turgut
T
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. durduran@stwing.upenn.edu
Choe
Regine
R
Yu
Guoqiang
G
Zhou
Chao
C
Tchou
Julia C
JC
Czerniecki
Brian J
BJ
Yodh
Arjun G
AG
D001783:Blood Flow Velocity; D001943:Breast Neoplasms / Q000098:blood supply* / Q000473:pathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods