Outcome of heart transplantation in patients with amyloid cardiomyopathy.
BACKGROUND
We retrospectively reviewed the United Network for Organ Sharing (UNOS) database to assess the survival of patients with amyloidosis who were treated by heart transplantation.


METHODS
Over a 15-year period, 69 patients had received orthotopic heart transplants and were entered into the database with the diagnosis of amyloidosis. The cohort consisted of 38 men and 31 women. Mean age was 51 years.


RESULTS
There were 5 operative deaths and 29 late deaths at a mean follow-up of 40 months. Nine patients died of amyloid-related complications, and one developed graft vasculopathy and was retransplanted.


CONCLUSIONS
Survival was influenced by recipient's sex (1-year survival 84% for men vs 64% for women, p = 0.003) but not by transplant era, ischemia time, or UNOS status.
Kpodonu
Jacques
J
Division of Cardiothoracic Surgery, Department of Surgery, University of Illinois, Chicago, Illinois 60612, USA.
Massad
Malek G
MG
Caines
Amitra
A
Geha
Alexander S
AS
D000682:Amyloid / Q000378:metabolism; D009202:Cardiomyopathies / Q000378:metabolism / Q000601:surgery*; D002423:Cause of Death; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
D000682:Amyloid