[Levels of some cytokines and antibodies to hepatitis C virus in patients with chronic hepatitis C].
The comparison of the levels of some cytokines (tumor necrosis factor alpha (TNF-alpha), IL-1beta, IL-2, IL-4) in the blood serum of patients with chronic hepatitis C (CHC) having different antibody spectrum was carried out. In CHC patients increased levels of the serum cytokines IL-1beta, TNF-alpha under study in comparison with cytokine levels in donor sera was noted. In patients with detected antiNS5 and antiHCV IgM and antiNS5 HCV the level of IL-1beta was significantly higher than that in CHC patients without antibodies in sera. A change in the levels of proinflammatory and anti-inflammatory cytokines in the blood sera of CHC patients may be of significant diagnostic and prognostic importance.
Krasavtsev
E L
EL
Mitsura
V M
VM
Zhavoronok
S V
SV
D016207:Cytokines / Q000097:blood*; D016174:Hepacivirus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000097:blood*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D017361:Viral Nonstructural Proteins / Q000276:immunology; D012324:RNA-Dependent RNA Polymerase
D016207:Cytokines; D018937:Hepatitis C Antibodies; D007075:Immunoglobulin M; D007375:Interleukin-1; D007376:Interleukin-2; D015847:Interleukin-4; D014409:Tumor Necrosis Factor-alpha; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase