Identification of serovar-specific single-nucleotide polymorphisms of C. Trachomatis omp1 gene.
Complete sequences of omp1 gene encoding chlamydial main outer membrane protein were analyzed in 76 clinical strains of C. trachomatis. Thirty-four serovar-specific single-nucleotide polymorphisms were identified, 20 of them meet two criteria: unique position of the nucleotide and unique nucleotide substitution. Evaluation of serovar-specific single-nucleotide polymorphisms of omp1 gene can appreciably simplify and accelerate genetic diagnosis of C. trachomatis serovars.
Sharkeev
V I
VI
Institute of Physicochemical Medicine, Ministry of Health of Russian Federation, Moscow.
Torshin
I Y
IY
Shkarupeta
M M
MM
Akopian
T A
TA
Lazarev
V N
VN
Govorun
V M
VM
D002692:Chlamydia trachomatis / Q000235:genetics*; D014644:Genetic Variation; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D018272:Porins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013045:Species Specificity
D018272:Porins; C071677:omp1 protein, Chlamydia trachomatis