title: An attempt to integrate Western and Chinese medicine: rationale for applying Chinese medicine as chronotherapy against cancer.
abstract: Current Western medical treatment lays its main emphasis on evidence-based medicine (EBM) and cure is assessed by quantifying the effects of treatment statistically. In contrast, in Chinese medicine, cure is generally assessed by evaluating the patient's "pattern" (Zheng) [cf. Glossary] and medicines are prescribed according to this. We believe that traditional Chinese medicine (TCM) cannot be evaluated precisely according to Western principles, in which a constant amount of the same medicine is given to a group of patients to be evaluated. When assessing cure using TCM, Zheng is more important than the determination of medical effects. This means that quantitative evaluation of TCM treatment can be very difficult. In this paper, we focused on the Yin-Yang [cf. Glossary]balance to determine Zheng, and at the same time attempted to determine the treatment effects by applying the concept of regulation of Yin-Yang according to chronotherapeutic principles. According to Zheng, advanced cancer patients generally lack both Yin and Yang. Chinese medical treatment therefore seeks to supplement both Yin and Yang. However, we divided patients into two groups and compared them with respect to survival. One group was administered a predominantly Yang (Qi) [cf. Glossary] tonic herbal treatment during the daytime, while the other group was administered Yin (Blood) [cf. Glossary] tonics during night time. A comparison of the results of treatment showed that the patients in the group receiving Yang (Qi) replenishment during the daytime lived longer than patients receiving Yin (Blood) nourishment during the night. Moreover, the patients in the daytime Yang (Qi) replenishment group also fared significantly better than patients treated solely by Western methods.
authors.affiliation: Shinyamanote Hospital, 3-6-1 Suwacho Higashimurayama-city, Tokyo 189-0021, Japan. kiyo-1712@jcom.home.ne.jp
authors.forename: K
authors.initials: K
authors.lastname: Seki
authors.forename: M
authors.initials: M
authors.lastname: Chisaka
authors.forename: M
authors.initials: M
authors.lastname: Eriguchi
authors.forename: H
authors.initials: H
authors.lastname: Yanagie
authors.forename: T
authors.initials: T
authors.lastname: Hisa
authors.forename: I
authors.initials: I
authors.lastname: Osada
authors.forename: T
authors.initials: T
authors.lastname: Sairenji
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000328:Adult; D000368:Aged; D019454:Chronotherapy; D003469:Culture; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D009711:Nucleotides / Q000097:blood; D016019:Survival Analysis; D016709:Yin-Yang
chemical_list: D004365:Drugs, Chinese Herbal; D009711:Nucleotides