title: Circulating immune parameters predicting the progression from hospital-acquired pneumonia to septic shock in surgical patients.
abstract: BACKGROUND
  Hospital-acquired pneumonia after surgery is one of the major causes of septic shock. The excessive inflammatory response appears to be responsible for the increased susceptibility to infections and subsequent sepsis. The primary aim of this study was to investigate immune parameters at the onset of pneumonia, before the development of subsequent septic shock. The secondary aim was to investigate the usefulness of these immune parameters in predicting progression from hospital-acquired pneumonia to septic shock.
  
  
  METHODS
  This prospective clinical study included 76 patients with the diagnosis of hospital-acquired pneumonia. Approval was obtained from the local institutional ethics committee and relatives of the patients gave informed consent. Of the 76 patients, 29 subsequently developed septic shock. All patients were included within 4 h of establishing the diagnosis of hospital-acquired pneumonia (first collection of blood samples and the analysis of immune mediators). In addition, we defined early (within 12 h of onset of septic shock) and late (within 72 to 96 h of onset) stages of septic shock for the collection of blood samples and the analysis of immune mediators. The immune parameters tumor necrosis factor-alpha, IL-1beta, IL-6, IL-8 and IL-10 as well as the endothelial leucocyte adhesion molecule were analyzed.
  
  
  RESULTS
  In the pneumonia group with subsequent septic shock, levels of IL-1beta, IL-6, IL-8 and IL-10 were significantly increased before the onset of septic shock compared to patients without subsequent septic shock. This progression was best predicted by IL-1beta, IL-6, IL-8 and IL-10 (area under the curve > or = 0.8).
  
  
  CONCLUSIONS
  At the onset of hospital-acquired pneumonia, a significant relevant systemic cytokine mediated response had already been initiated. It might, therefore, be possible to identify patients at risk for septic shock with these predictive markers during early pneumonia. In addition, immune modulating therapy might be considered as adjuvant therapy.
authors.affiliation: Department of Anesthesiology and Intensive Care, Charité-Universitaetsmedizin Berlin, Campus Mitte, Germany. vera.vdossow@charite.de
authors.forename: Vera
authors.initials: V
authors.lastname: von Dossow
authors.forename: Koschka
authors.initials: K
authors.lastname: Rotard
authors.forename: Uwe
authors.initials: U
authors.lastname: Redlich
authors.forename: Ortrud Vargas
authors.initials: OV
authors.lastname: Hein
authors.forename: Claudia D
authors.initials: CD
authors.lastname: Spies
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003428:Cross Infection / Q000097:blood / Q000150:complications* / Q000276:immunology*; D018450:Disease Progression; D006339:Heart Rate; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008875:Middle Aged; D010101:Oxygen Consumption; D011014:Pneumonia / Q000097:blood / Q000150:complications* / Q000276:immunology*; D011183:Postoperative Complications / Q000097:blood / Q000276:immunology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012772:Shock, Septic / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D016019:Survival Analysis
chemical_list: D015415:Biomarkers