title: Conjugated linoleic acid enhanced the immune function in broiler chicks.
abstract: This study was undertaken to investigate the growth performance and immune responses of broiler chicks fed diets supplemented with conjugated linoleic acid (CLA). Two hundred and forty day-old Arbor Acre male broiler chicks were randomly allotted into four dietary treatments with different inclusion levels of CLA (0, 2.5, 5.0 or 10.0 g pure CLA/kg) for 6 weeks. Growth performance, lysozyme activity, peripheral blood mononuclear cell (PBMC) proliferation, prostaglandin E2 (PGE2) synthesis and antibody production were investigated. There were no significant differences in growth performance among treatments (P>0.05). Chicks fed 10.0 g CLA/kg diet produced 40 % and 49 % more lysozyme activity in serum and spleen than the control group at 21 d of age (P<0.05). Dietary CLA enhanced the PBMC proliferation in response to concanavalin A at the age of 21 and 42 d (P<0.05). Systemic and peripheral blood lymphocytic synthesis of PGE2 in chicks fed 10.0 g CLA/kg diet was significantly decreased by 57 % and 42 % compared to chicks fed control diet (P<0.05). Antibody production to sheep red blood cell and bovine serum albumin were elevated in either 2.5 or 10.0 g CLA/kg dietary treatments (P<0.05). The results indicated dietary CLA could enhance the immune response in broiler chicks, but did not alter the growth performance.
authors.affiliation: Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100094, P. R. China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Zhang
authors.forename: Yuming
authors.initials: Y
authors.lastname: Guo
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism; D000917:Antibody Formation / Q000276:immunology; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D002645:Chickens / Q000254:growth & development / Q000276:immunology*; D019587:Dietary Supplements; D015232:Dinoprostone / Q000032:analysis / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008297:Male; D009113:Muramidase / Q000378:metabolism; D011897:Random Allocation
chemical_list: D000890:Anti-Infective Agents; D044243:Linoleic Acids, Conjugated; D009113:Muramidase; D015232:Dinoprostone