title: Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes.
abstract: Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2-/-) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2-/- PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.
authors.affiliation: Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland.
authors.forename: Maryse
authors.initials: M
authors.lastname: Letiembre
authors.forename: Hakim
authors.initials: H
authors.lastname: Echchannaoui
authors.forename: Philipp
authors.initials: P
authors.lastname: Bachmann
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Ferracin
authors.forename: Concepción
authors.initials: C
authors.lastname: Nieto
authors.forename: Manuel
authors.initials: M
authors.lastname: Espinosa
authors.forename: Regine
authors.initials: R
authors.lastname: Landmann
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006098:Granulocytes / Q000737:chemistry / Q000276:immunology / Q000382:microbiology*; D049452:Green Fluorescent Proteins / Q000032:analysis; D051379:Mice; D018345:Mice, Knockout; D010084:Oxidation-Reduction; D010587:Phagocytosis / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000276:immunology*; D051195:Toll-Like Receptor 2 / Q000172:deficiency* / Q000235:genetics
chemical_list: D051195:Toll-Like Receptor 2; D049452:Green Fluorescent Proteins