Sensitive and isotope selective (14NO/15NO) online detection of nitric oxide by faraday-laser magnetic resonance spectroscopy.
The monitoring of trace amounts of nitric oxide (NO) is of great interest for biomedical applications. High-resolution infrared spectroscopy, like laser magnetic resonance spectroscopy (LMRS), is a versatile technique for the quantitative and isotope-selective analysis of low concentrations of NO. The ability to distinguish between different NO isotopomeres is of special interest for pharmaceutical and biomedical applications when tracer investigations are performed. With LMRS using Faraday modulation, a sensitivity of 1-2 ppbV for 15NO can be achieved. With further improvements and development of the sensor, we expect a sub-ppbV sensitivity.
Gäbler
Ralph
R
Institute for Trace Gas Technology, Augustin, Germany.
Lehmann
Jochen
J
D002248:Carbon Monoxide / Q000737:chemistry; D007834:Lasers; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009569:Nitric Oxide / Q000737:chemistry*; D009587:Nitrogen Isotopes; D012680:Sensitivity and Specificity
D009587:Nitrogen Isotopes; D009569:Nitric Oxide; D002248:Carbon Monoxide