title: Intestinal transplantation for the treatment of neoplastic disease.
abstract: BACKGROUND
  Authors reviewed single center experience of intestinal transplantation for treatment of intra-abdominal neoplastic disease.
  
  
  METHODS
  There were 25 auto- or allograft transplantations in 21 patients; desmoid tumor (14), neuroendocrine tumor (2), adenocarcinoma (2), hemangioma (1), lymphoma (1), and solid pseudopapillary tumor (1). Medical records were reviewed for cause of graft loss and mortality, recurrent neoplasm, and quality of life. Survival was analyzed using Kaplan-Meier method.
  
  
  RESULTS
  There were 11 graft losses; mortality with functioning graft (6), ischemic necrosis (2), acute or chronic rejection (2), and arterial thrombosis (1) during 38 months of mean follow-up. Seven patients died because of recurrent neoplasm and transplant related complications. Six patients experienced recurrent disease; three desmoid tumor (3/14), two adenocarcinoma (2/2), and one neuroendocrine tumor (1/2). Recurrent desmoid tumors were successfully treated with simple excision. Patient and graft survival in the desmoid tumor are 69.2% and 50.0% at 5 years after transplant. Among 14 survivors, 2 need parenteral nutrition or intravenous hydration. Twelve patients are working full time.
  
  
  CONCLUSIONS
  Intestinal transplantation is a reasonable life-saving treatment for catastrophic intra-abdominal neoplastic diseases.
authors.affiliation: Department of Surgery, Liver/GI Transplant, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. jmoon@med.miami.edu
authors.forename: Jang I
authors.initials: JI
authors.lastname: Moon
authors.forename: Gennaro
authors.initials: G
authors.lastname: Selvaggi
authors.forename: Seigo
authors.initials: S
authors.lastname: Nishida
authors.forename: David M
authors.initials: DM
authors.lastname: Levi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Kato
authors.forename: Philip
authors.initials: P
authors.lastname: Ruiz
authors.forename: Pablo
authors.initials: P
authors.lastname: Bejarano
authors.forename: Juan R
authors.initials: JR
authors.lastname: Madariaga
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Tzakis
mesh_terms: D000008:Abdominal Neoplasms / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D004386:Duodenum / Q000637:transplantation; D005260:Female; D018221:Fibromatosis, Abdominal / Q000473:pathology / Q000601:surgery*; D018222:Desmoid Tumors / Q000473:pathology / Q000601:surgery; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007422:Intestines / Q000637:transplantation*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D011788:Quality of Life; D012008:Recurrence; D013270:Stomach / Q000637:transplantation; D016019:Survival Analysis; D014184:Transplantation, Homologous