Effects of in utero and lactational exposure to bisphenol A on thyroid status in F1 rat offspring.
Bisphenol A (BPA), a xenoestrogen, has been reported to mimic the actions of estrogen or to affect the endocrine glands in vivo and in vitro. In this study, we examined whether in utero and lactational exposure to BPA alters thyroid status in rat F1 offspring. Dams were orally administered various doses of BPA (0, 4 or 40 mg/kg body weight per day) from gestation day (GD) 6 through postnatal day (PND) 20. The BPA and control groups did not differ significantly with respect to plasma thyroxine (T4) concentration. The thyroid glands from the BPA groups had normal T4 responses to exogenous thyroid-stimulating hormone in vivo. These results suggest that in utero and lactational exposure (indirect exposure) to BPA (4-40 mg/kg/day, GD 6 - PND 20) does not affect thyroid functions in the F1 generation of male and female rats.
Kobayashi
Kenichi
K
Department of Health Effects Research, National Institute of Industrial Health, 6-21-1, Nagao, Tama-Ku, Kawasaki 214-8585, Japan.
Miyagawa
Muneyuki
M
Wang
Rui-Sheng
RS
Suda
Megumi
M
Sekiguchi
Soichiro
S
Honma
Takeshi
T
D000818:Animals; D001559:Benzhydryl Compounds; D016022:Case-Control Studies; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008297:Male; D023421:Models, Animal; D010636:Phenols / Q000494:pharmacology / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin; D013974:Thyroxine / Q000097:blood*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D013972:Thyrotropin; D013974:Thyroxine; C006780:bisphenol A; D000098826:Bisphenol A Compounds