title: Incidence of endometrial carcinoma in patients with endometrial hyperplasia.
abstract: OBJECTIVE
  The purpose of this retrospective study was to establish the risk of developing endometrial adenocarcinoma in patients diagnosed with endometrial hyperplasia.
  
  
  METHODS
  The incidence of endometrial hyperplasia and its relation with endometrial adenocarcinoma was evaluated in 1,139 patients who presented with abnormal bleeding between January 2000 and December 2004; D&C was performed in all cases. There were 591 (51.88%) cases of simple endometrial hyperplasia, out of which 110 (18.61% from 51.88%) cases had atypia, 60 (5.26%) cases of complex hyperplasia, out of which 19 (31.66% from 5.26%) had atypia, and the remaining 488 (42.84%) had different forms of mixed hyperplasia.
  
  
  RESULTS
  The incidence of endometrial adenocarcinoma was 3.87% in atypical hyperplasia and 0.81% in other forms, and was related only to cases with atypia in which the incidence was 0.61%.
  
  
  CONCLUSIONS
  The most indicated measure to prevent endometrial carcinoma in cases with complex endometria hyperplasia with atypia is hysterectomy, while for other forms of hyperplasia, hormonal treatment is used but only under strict control.
authors.affiliation: Department of Obstetrics and Gynaecology, Municipal Hospital of Craiova, Romania.
authors.forename: L
authors.initials: L
authors.lastname: Novac
authors.forename: T
authors.initials: T
authors.lastname: Grigore
authors.forename: N
authors.initials: N
authors.lastname: Cernea
authors.forename: M
authors.initials: M
authors.lastname: Niculescu
authors.forename: S
authors.initials: S
authors.lastname: Cotarcea
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D017677:Age Distribution; D004714:Endometrial Hyperplasia / Q000453:epidemiology / Q000209:etiology; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D008499:Medical Records; D008875:Middle Aged; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology