[Recent progress of catecholamines--mainly focusing on metabolic syndrome].
Although catecholamine is a well-known classical hormone, its precise pathophysiological role remains obscure. Recently, growing evidence suggests that this hormone plays a causative role in several common diseases such as hypertension, diabetes, and dyslipidemia (metabolic syndrome). Thus, the discussion that follows will mainly focus on our data, including: 1) leptin as well Ang II subtype-2 receptor (AT2), assumed to be a key molecule for metabolic syndrome, much involved in regulating catecholamine synthesis and secretion. 2) Recent progress of pheochromocytoma (SDHX and Peptidergic Regulation). 3) Chromogranin A, as a possible marker for chronic sympatho-adrenal activities.
Takekoshi
Kazuhiro
K
Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8575.
D000310:Adrenal Gland Neoplasms / Q000235:genetics; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis; D015415:Biomarkers; D002395:Catecholamines / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology; D053379:Chromogranin A; D002864:Chromogranins; D002908:Chronic Disease; D006801:Humans; D007506:Iron-Sulfur Proteins / Q000235:genetics; D020738:Leptin / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics; D024821:Metabolic Syndrome / Q000209:etiology*; D009154:Mutation; D010673:Pheochromocytoma / Q000235:genetics; D021122:Protein Subunits / Q000235:genetics; D044139:Receptor, Angiotensin, Type 2 / Q000502:physiology; D013385:Succinate Dehydrogenase / Q000235:genetics
D015415:Biomarkers; D002395:Catecholamines; D053379:Chromogranin A; D002864:Chromogranins; D007506:Iron-Sulfur Proteins; D020738:Leptin; D008565:Membrane Proteins; D021122:Protein Subunits; D044139:Receptor, Angiotensin, Type 2; C491545:SDHD protein, human; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase