Potassium channels, memory T cells, and multiple sclerosis.
Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal damage that result in disabling neurological deficits. Here the authors explain the rationale for the use of inhibitors of the Kv1.3 K+ channel in immune cells as a therapy for multiple sclerosis and other autoimmune disorders.
Beeton
Christine
C
Department of Physiology and Biophysics, Medical School, University of California, Irvine, 92697, USA.
Chandy
K George
KG
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy; D015551:Autoimmunity; D006801:Humans; D007156:Immunologic Memory; D051664:Kv1.3 Potassium Channel / Q000037:antagonists & inhibitors*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
D051664:Kv1.3 Potassium Channel