title: Postinfectious myeloradiculoneuropathy with cranial nerve involvements associated with human herpesvirus 7 infection.
abstract: BACKGROUND
  Infection with human herpesvirus 7 (HHV-7) generally results in a febrile illness with accompanying exanthema subitum.
  
  
  OBJECTIVE
  To ascertain and describe the role of HHV-7 in a case of acute myeloradiculoneuropathy.
  
  
  METHODS
  A previously healthy young man with complaints of motor weakness, dysphasia, and nasal voice.
  
  
  METHODS
  Serological examinations were performed with the patient's serum. We also examined virus genome DNA in cerebrospinal fluid by regular and real-time polymerase chain reaction. Moreover, we checked the antiganglioside antibody level in the patient's serum samples by the immunoblot analysis.
  
  
  RESULTS
  Serological studies revealed significant change in titers of antibodies against cytomegalovirus, Epstein-Barr virus, and HHV-7, but only HHV-7 genome was detected in the cerebrospinal fluid, with its disappearance after therapy. No antiganglioside antibody was detected in the patient's serum.
  
  
  CONCLUSIONS
  The unique clinical picture of the present patient might be closely related to the reactivation of HHV-7 in the nervous system.
authors.affiliation: Department of Neurology, Fujita Health University School of Medicine, Aichi, Japan.
authors.forename: Takateru
authors.initials: T
authors.lastname: Mihara
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Mutoh
authors.forename: Tetsusi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yano
authors.forename: Yoshizo
authors.initials: Y
authors.lastname: Asano
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D003391:Cranial Nerves / Q000473:pathology / Q000503:physiopathology* / Q000821:virology*; D004279:DNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid / Q000150:complications*; D016199:Herpesvirus 7, Human; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D003294:Seizures, Febrile / Q000150:complications* / Q000821:virology
chemical_list: D004279:DNA, Viral; D012333:RNA, Messenger