title: Stereoselective synthesis of the C1-C13 fragment of 2,3-dihydrodorrigocin A.
abstract: [Chemical reaction: see text] The first synthesis of the C1-C13 fragment of 2,3-dihydrodorrigocin A has been achieved from 6-bromohexanoic acid in 14 linear steps and an overall yield of 2%. The configurations of the stereogenic centers C8, C9, and C10 have been determined to be the same as for migrastatin.
authors.affiliation: Department of Chemistry and Biology, Conforma Therapeutics Corporation, 9393 Towne Centre Drive, Suite 240, San Diego, California 92121, USA. jlebrazidec@conformacorp.com
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Le Brazidec
authors.forename: Charles A
authors.initials: CA
authors.lastname: Gilson
authors.forename: Marcus F
authors.initials: MF
authors.lastname: Boehm
mesh_terms: D006900:Hydroxylation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010881:Piperidones / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: D007202:Indicators and Reagents; D010881:Piperidones; C089606:dorrigocin A