title: Near normalisation of lumbar spine bone density in young women with osteopenia recovered from adolescent onset anorexia nervosa: a longitudinal study.
abstract: To investigate the effect of the progression of adolescent onset anorexia nervosa (AN) on bone parameters we followed two cohorts (Disease cohort and recovered cohort) of adolescents for a total of 5.2 years. In the 'Disease' cohort (n = 18), lumbar spine bone density (BMD) was reduced by 0.6 SD after 0.8 years of disease and was reduced a further 1.0 SD after a total 2.5 years of disease (p < 0.001). At the third lumbar vertebra there was bone loss (-3.7%, p < 0.05) resulting in reduced volumetric BMD (-5.1%, p < 0.08). In the 'recovered' cohort, lumbar spine BMD was reduced by 1.9 SD after 1.7 years of disease, and increased by 1.5 SD after 2.7 years of recovery (p < 0.001). At the third lumbar vertebra there was an increase in bone mass (20.5%, p < 0.001) and bone volume (14.1%, p < 0.001), resulting in increased volumetric BMD (6.3%, p < 0.08). Normalisation of lumbar spine BMD may be achieved in patients with adolescent onset AN when the successful recovery of body weight is combined with the return of regular menses.
authors.affiliation: Centre for Physical Activity and Nutrition Research Deakin University 221 Burwood Hwy, Burwood Australia 3125. shona.bass@deakin.edu.au
authors.forename: Shona L
authors.initials: SL
authors.lastname: Bass
authors.forename: Leanne
authors.initials: L
authors.lastname: Saxon
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Corral
authors.forename: Christine P
authors.initials: CP
authors.lastname: Rodda
authors.forename: Boyd J G
authors.initials: BJ
authors.lastname: Strauss
authors.forename: Daniel
authors.initials: D
authors.lastname: Reidpath
authors.forename: Caroline
authors.initials: C
authors.lastname: Clarke
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000856:Anorexia Nervosa / Q000150:complications / Q000503:physiopathology*; D001835:Body Weight; D015519:Bone Density; D001846:Bone Development; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000503:physiopathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008598:Menstruation; D013131:Spine / Q000503:physiopathology*; D013997:Time Factors