title: Analysis of contact lens intolerance by exploring neuroanatomic integration of ocular surface defense.
abstract: This paper reviews the anatomic, neuronal and mechanical factors that affect contact lens wear, and outlines several areas where compromised ocular surface defense arising from dysfunctional neuroanatomic integration might be the source of or a contributor to contact lens intolerance. Suggestions for clinical work-up by analyzing neuroanatomic integration are presented as a logical way to dissect this complex problem.
authors.affiliation: Ocular Surface Center and Ocular Surface Research & Education Foundation, 8780 SW 92 Street, Suite 203, Miami, FL 33176, USA.
authors.forename: Edgar M
authors.initials: EM
authors.lastname: Espana
authors.forename: Scheffer C G
authors.initials: SC
authors.lastname: Tseng