title: A case of avascular necrosis of the femoral head as initial presentation of chronic myelogenous leukemia.
abstract: Chronic myelogenous leukemia (CML) is a malignant clonal disorder of hemopoietic stem cells characterized by abnormal proliferation and accumulation of immature granulocyte. Leukostasis is one of the complications of CML and is characterized by partial or total occlusion of microcirculation by aggregation of leukemic cells and thrombi leading to respiratory, ophthalmic or neurologic symptoms. We experienced a rare case of avascular necrosis of the femoral head as the initial presentation of chronic myelogenous leukemia. A 24-year-old male patient was admitted to our hospital with pain in the right hip joint. The patient was diagnosed to be suffering from chronic myelogenous leukemia by packed marrow with granulocytic and megakaryocytic hyperplasia and the presence of Philadelphia chromosome. The right hip joint pain was attributed to avascular necrosis of the femoral head. And the avascular necrosis could be considered as the complication of chronic myelogenous leukemia due to microcirculatory obstruction of the femoral head. The avascular necrosis of the right femoral head was treated with bipolar hemiarthoplasty.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Moon
authors.forename: Byung Su
authors.initials: BS
authors.lastname: Kim
authors.forename: Hye Ryeon
authors.initials: HR
authors.lastname: Yun
authors.forename: Jung Hye
authors.initials: JH
authors.lastname: Choi
authors.forename: Young Yul
authors.initials: YY
authors.lastname: Lee
authors.forename: In Soon
authors.initials: IS
authors.lastname: Kim
authors.forename: Myung Ju
authors.initials: MJ
authors.lastname: Ahn
mesh_terms: D000328:Adult; D005271:Femur Head Necrosis / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male