Particle uptake by Peyer's patches: a pathway for drug and vaccine delivery.
Particle uptake by Peyer's patches offers the possibility of tailoring vaccines that can be delivered orally. However, particle uptake by the follicle-associated epithelium in the gastrointestinal tract depends on several different factors that are the physicochemical properties of the particles, the physiopathological state of the animal, the analytical method used to evaluate the uptake and finally the experimental model. These parameters do not allow a clear idea about the optimal conditions to target the Peyer's patches. The goal of this review is to clarify the role of each factor in this uptake.
Shakweh
Monjed
M
University of Paris-South, Faculty of Pharmacy, UMR CNRS 8612, 5 rue Jean-Batiste Clement, 92290 Chatenay-Malabry Cedex, France.
Ponchel
Gilles
G
Fattal
Elias
E
D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D010316:Particle Size; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014612:Vaccines / Q000008:administration & dosage*
D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D014612:Vaccines