title: Fibromyalgia and Gaucher's disease.
abstract: BACKGROUND
  Patients with symptomatic Gaucher's disease sometimes have non-specific symptoms (such as general malaise with widespread musculoskeletal pains) that respond poorly to enzyme replacement treatment. These may indicate fibromyalgia syndrome; if so, other therapeutic options might be more appropriate.
  
  
  OBJECTIVE
  To identify patients with Gaucher's disease for whom fibromyalgia-specific therapy may be therapeutic.
  
  
  METHODS
  Questionnaire-based survey.
  
  
  METHODS
  Adult patients (n = 109) with non-neuronopathic Gaucher's disease and adult healthy controls (n = 108) completed health-related questionnaires including the Fibromyalgia Impact Questionnaire, and underwent testing with a dolorimeter to ascertain sensitivity at 22 tender points.
  
  
  RESULTS
  Six patients, but no controls, met the criteria for fibromyalgia. Patients with fibromyalgia had a significantly greater incidence of co-morbidities (p = 0.014) relative to other patients with Gaucher's disease; four suffered from bone involvement and were receiving enzyme therapy, but two were untreated.
  
  
  CONCLUSIONS
  The presence of fibromyalgia-specific trigger points may result from multiple aetiologies, or may be an independently-sorting predisposition. Our findings cannot distinguish between these possibilities, but if fibromyalgia were the cause, enzyme replacement therapy would be expensive and inappropriate.
authors.affiliation: Gaucher Clinic, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel. gaucher@szmc.org.il.
authors.forename: A
authors.initials: A
authors.lastname: Brautbar
authors.forename: D
authors.initials: D
authors.lastname: Elstein
authors.forename: B
authors.initials: B
authors.lastname: Pines
authors.forename: N
authors.initials: N
authors.lastname: Krienen
authors.forename: J
authors.initials: J
authors.lastname: Hemmer
authors.forename: D
authors.initials: D
authors.lastname: Buskila
authors.forename: A
authors.initials: A
authors.lastname: Zimran
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000175:diagnosis; D005776:Gaucher Disease / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged