Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction.
Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.
Hayashi
Yujiro
Y
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hyashi@ci.kagu.tus.ac.jp
Gotoh
Hiroaki
H
Tamura
Tomohiro
T
Yamaguchi
Hirofumi
H
Masui
Ryouhei
R
Shoji
Mitsuru
M
D002384:Catalysis; D003545:Cysteine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D003545:Cysteine