Failure of HIV-2 viral load assay in a severely immunodeficient patient: clinical and therapeutic management issues.
We report the case of an HIV-2-infected patient with severe immunosupression despite undetectable plasma HIV-2 RNA. This immunovirological discordance was due to failure of the viral load assay and infection by an unknown HIV-2 subtype. Treatment was probably suboptimal, leading to the selection of several resistance mutations and treatment failure.
Fonquernie
Laurent
L
Service des Maladies Infectieuses et Tropicales, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184 rue du faubourg Saint-Antoine, 75012 Paris, France. laurent.fonquernie@sat.ap-hop-paris.fr
Eholié
Serge P
SP
Damond
Florence
F
Lacombe
Karine
K
Girard
Pierre-Marie
PM
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015498:HIV-2 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood*; D017211:Treatment Failure; D019562:Viral Load / Q000379:methods / Q000592:standards
D019380:Anti-HIV Agents; D012367:RNA, Viral