A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides.
[reaction: see text] CuI-catalyzed N-arylation of imidazoles with aryl bromides has been achieved in a near-homogeneous system that utilizes tetraethylammonium carbonate as base, 8-hydroxyquinoline as ligand, and H2O as cosolvent. Preliminary results with aryl chlorides are also reported.
Liu
Longbin
L
Chemical Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. lliu@amgen.com
Frohn
Mike
M
Xi
Ning
N
Dominguez
Celia
C
Hungate
Randy
R
Reider
Paul J
PJ
D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012995:Solubility; D013237:Stereoisomerism
D006846:Hydrocarbons, Halogenated; D007093:Imidazoles; D003300:Copper