Starch microparticles as vaccine adjuvant.
The demand for new vaccine adjuvants is well documented. New purified antigens from parasites, bacterial or viral pathogens, as well as recombinant subunit antigens and synthetic peptides, are often inherently weak immunogens; therefore, they need some kind of adjuvant to help initiate an immune response. In addition, there are very few adjuvants using the potential of the mucosal immune system, which may play an important role in the defence against air- and food-borne infections. Starch is a natural biocompatible and biodegradable polymer that is suitable for the production of various particulate adjuvant formulations, which can induce mucosal as well as systemic immune responses. This review gives an account of the different starch adjuvants used in immunisation studies. In particular, the properties of polyacryl starch microparticles as an oral vaccine adjuvant that induce protective immune responses in mice challenge experiments are summarised. In addition, a diphtheria booster vaccine has been proposed to be used to proving the concept in man and the possibilities to design an efficient vaccine formulation for human use are discussed.
Rydell
Niclas
N
Uppsala University, Department of Pharmacy, Biomedical Centre, Sweden.
Stertman
Linda
L
Sjöholm
Ingvar
I
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005079:Excipients; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects; D049329:Nanostructures; D013213:Starch; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000276:Adjuvants, Immunologic; D005079:Excipients; D014612:Vaccines; D013213:Starch