Structural stability and prebiotic properties of resistant starch type 3 increase bile acid turnover and lower secondary bile acid formation.
Microbial metabolism is essential in maintaining a healthy mucosa in the large bowel, preferentially through butyrate specific mechanisms. This system depends on starch supply. Two structurally different resistant starches type 3 (RS3) have been investigated with respect to their resistance to digestion, fermentability, and their effects on the composition and turnover of bile acids in rats. RSA (a mixture of retrograded maltodextrins and branched high molecular weight polymers), which is more resistant than RSB (a retrograded potato starch), increased the rate of fermentation accompanied by a decrease of pH in cecum, colon, and feces. Because they were bound to RS3, less bile acids were reabsorbed, resulting in a higher turnover through the large bowel. Because of the rise of volume, the bile acid level was unchanged and the formation of secondary bile acids was partly suppressed. The results proved a strong relation between RS3, short chain fatty acid production, and microflora. However, butyrate specific benefits are only achieved by an intake of RS3 that result in good fermentation properties, which depend on the kind of the resistant starch structures.
Dongowski
Gerhard
G
German Institute of Human Nutrition Potsdam-Rehbruecke, Research Group Food Chemistry and Preventive Nutrition, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.
Jacobasch
Gisela
G
Schmiedl
Detlef
D
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D004063:Digestion; D004355:Drug Stability; D004435:Eating; D004734:Energy Metabolism; D005243:Feces / Q000737:chemistry; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D007422:Intestines / Q000737:chemistry / Q000382:microbiology; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D019936:Probiotics; D051381:Rats; D013213:Starch / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D015430:Weight Gain
D001647:Bile Acids and Salts; D013213:Starch; D009584:Nitrogen