Primary synovial sarcoma of the mitral valve.
Primary cardiac synovial sarcoma is a rare malignancy, comprising approximately 5% of cardiac sarcomas and less than 0.1% of all primary cardiac tumors. Herein, we describe a synovial sarcoma arising on the anterior mitral leaflet in a 66-year-old man. The histopathologic diagnosis was supported by the immunohistochemical profile and the presence of the SYT-SSX1 fusion transcript identified by molecular genetic studies.
Miller
Dylan V
DV
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Deb
Arjun
A
Edwards
William D
WD
Zehr
Kenton J
KJ
Oliveira
Andre M
AM
D000368:Aged; D001026:Coronary Artery Bypass; D004452:Echocardiography; D006338:Heart Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008943:Mitral Valve / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein