title: [Range of combined treatment of locally advanced skin cancer].
abstract: Due to combined use of surgery, chemo- and radiotherapy, 58.8% of patients with locally advanced squamous cell carcinoma survived for 5 years. More organ-saving operations could be performed as a result of administering cisplatin, bleomycin and 5-fluorouracil chemotherapy in conjunction with radiation and subsequent surgery. Greater extent of tumor excision and microsurgery involved lower incidence of relapse. Yet, the preliminary results of our combined treatment pointed to relatively high frequency of objective response matched by lower incidence of relapse which calls for further investigation.
authors.forename: T K
authors.initials: TK
authors.lastname: Kharatishvili
authors.forename: S A
authors.initials: SA
authors.lastname: Tiuliandin
authors.forename: S A
authors.initials: SA
authors.lastname: Khatyrëv
authors.forename: V A
authors.initials: VA
authors.lastname: Sobolevskiĭ
authors.forename: S I
authors.initials: SI
authors.lastname: Tkachev
authors.forename: S I
authors.initials: SI
authors.lastname: Ivanov
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Vishnevskaia
authors.forename: R M
authors.initials: RM
authors.lastname: Karapetian
authors.forename: E E
authors.initials: EE
authors.lastname: Kovalevskiĭ
mesh_terms: D017677:Age Distribution; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D020360:Neoadjuvant Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D001761:Bleomycin; D002945:Cisplatin; D005472:Fluorouracil