Screening of plants used in Danish folk medicine to treat epilepsy and convulsions.
Aqueous and ethanolic extracts of 42 plants used in Danish folk medicine for the treatment of epilepsy and convulsions, or for inducing sedation, were tested for affinity to the GABA(A)-benzodiazepine receptor in the flumazenil-binding assay. Ethanolic extracts of leaves of Primula elatior and Primula veris and aerial parts of Tanacetum parthenium exhibited good, dose-dependent affinity.
Jäger
Anna K
AK
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, 2100 Copenhagen O, Denmark. ankj@dfuni.dk
Gauguin
Bente
B
Adsersen
Anne
A
Gudiksen
Lene
L
D003718:Denmark; D004827:Epilepsy / Q000628:therapy*; D008519:Medicine, Traditional; D010946:Plants, Medicinal / Q000145:classification*; D012640:Seizures / Q000628:therapy*