2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications.
H(2)O(2) is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H(2)O(2) generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H(2)O(2) reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H(2)O(2) signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.
Kang
Sang Won
SW
Center for Cell Signaling Research and Division of Molecular Life Science, Ewha Womans University, Seoul 120-750, Korea. kangsw@ewha.ac.kr
Rhee
Sue Goo
SG
Chang
Tong-Shin
TS
Jeong
Woojin
W
Choi
Min Hee
MH
D000595:Amino Acid Sequence; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D018384:Oxidative Stress / Q000502:physiology*; D010544:Peroxidases / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D054464:Peroxiredoxins; D017382:Reactive Oxygen Species / Q000378:metabolism*; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*
D017382:Reactive Oxygen Species; D010544:Peroxidases; C504194:2-cys peroxiredoxin, human; D054464:Peroxiredoxins; D017479:Receptors, Platelet-Derived Growth Factor