Synthesis, antibacterial and antifungal activity of some new pyridazinone metal complexes.
The new various metal complexes of 5-benzoyl-4-hydroxy-2-methyl-6-phenyl-2H-pyridazin-3-one were synthesized. All the complexes were evaluated for their antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi using microdilution procedure. The Cd(II) and Ni(II) complexes exhibited selective and effective activities against one Gram-positive bacterium (Staphylococcus aureus ATCC 6538), one Gram-negative bacterium (Pseudomonas putida ATCC 12633) and against two yeast (Candida albicans ATCC 27541 and Candida tropicalis 1828) in contrast to poor activity observed other microorganisms. The new synthesized complexes were characterized using IR, 1H-NMR and UV spectral data together with elemental analysis.
Sönmez
Mehmet
M
Department of Chemistry, Faculty of Science and Arts, Yüzüncü Yil University, 65080 Van, Turkey. vansonmez@hotmail.com
Berber
Ismet
I
Akbaş
Esvet
E
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D019187:Cadmium Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry / Q000378:metabolism; D016958:Pseudomonas putida / Q000187:drug effects*; D011724:Pyridazines / Q000138:chemical synthesis / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D019187:Cadmium Compounds; D011724:Pyridazines; D009532:Nickel