Current advances in sustained-release systems for parenteral drug delivery.
Major progresses in the development of parenteral sustained-release systems have been made in recent years as evidenced by the regulatory approval and market launch of several new products. Both the availability of novel carrier materials and the advances in method of fabrication have contributed to these commercial successes. With the formulation challenges associated with biologics, new delivery systems have also been evolved specifically to address the unmet needs in the parenteral sustained release of proteins. In this review paper, different new carriers systems and preparation methods are discussed with special focus on their applications to biologicals.
Shi
Yi
Y
Abbott Laboratories, Global Pharmaceutical Research & Development, Abbott Park, IL 60064, USA.
Li
Luk Chiu
LC
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004343:Drug Implants / Q000737:chemistry; D005782:Gels; D006016:Glycolates / Q000737:chemistry; D006801:Humans; D007267:Injections; D019344:Lactic Acid; D008081:Liposomes; D008863:Microspheres; D049329:Nanostructures; D049388:Polyanhydrides / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry
D003692:Delayed-Action Preparations; D004343:Drug Implants; D005782:Gels; D006016:Glycolates; D008081:Liposomes; D049388:Polyanhydrides; D011091:Polyesters; D011108:Polymers; D011506:Proteins; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; D011100:Polyglycolic Acid; D019344:Lactic Acid