title: Leukemoid reaction in association with bone marrow necrosis due to metastatic prostate cancer.
abstract: An 80-year-old man presented to the internist with fever, fatigue and leukocytosis up to 66.8 x 10(3)/microl. Although a chronic myelogenous leukemia was initially suspected, he was diagnosed as metastatic bone marrow tumor with bone marrow necrosis from primary prostate cancer on the basis of the clinical and pathological findings. The serum concentrations of IL-6 and TNF-alpha were mildly elevated to 65.0 pg/ml and, 54.0 pg/ml respectively. It is probable that these humoral factors were partially responsible for the leukemoid reaction although other factors induced by the bone marrow necrosis with bone marrow metastasis of prostate cancer are also likely involved.
authors.affiliation: First Department of Internal Medicine, Ehime University School of Medicine.
authors.forename: Taichi
authors.initials: T
authors.lastname: Azuma
authors.forename: Ikuya
authors.initials: I
authors.lastname: Sakai
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Nozomu
authors.initials: N
authors.lastname: Tanji
authors.forename: Akito
authors.initials: A
authors.lastname: Watanabe
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Uchida
authors.forename: Hirosi
authors.initials: H
authors.lastname: Narumi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yakushijin
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hato
authors.forename: Masaki
authors.initials: M
authors.lastname: Yasukawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology*; D019046:Bone Marrow Neoplasms / Q000150:complications* / Q000556:secondary*; D006801:Humans; D007955:Leukemoid Reaction / Q000209:etiology*; D008297:Male; D009336:Necrosis / Q000209:etiology; D011471:Prostatic Neoplasms / Q000473:pathology*