Critical role of ITIM-bearing FcgammaR on DCs in the capture and presentation of native antigen to B cells.
The contribution of dendritic cells (DCs) to antibody responses through antigen-unspecific B cell costimulation is well documented. now demonstrate that the ITIM-bearing FcgammaRIIB allows DCs to recycle internalized native antigen (Ag) for presentation to B cells, a process that might be critical for the initiation of humoral responses.
Dubois
Bertrand
B
INSERM U404 "Immunité et Vaccination", IFR-128 Biosciences Lyon Gerland, 21 avenue Tony Garnier, 69365 Lyon Cedex 07, France.
Caux
Christophe
C
D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology* / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D017452:Receptors, IgG / Q000276:immunology*
D000941:Antigens; D017452:Receptors, IgG