Lipid peroxidation levels in patients with acute brucellosis.
The purpose of this study was to investigate levels of lipid peroxidation, indicated by plasma malondialdehyde (MDA), with consideration of clinical status and treatment outcomes in patients with acute brucellosis. Plasma MDA levels were measured in patients with acute brucellosis and healthy subjects. Significantly higher MDA levels were detected in plasma of patients with acute brucellosis compared to controls (P<0.01). Plasma levels of MDA were significantly decreased after the brucellosis treatment (P<0.01). The results of the present study indicate for the first time that a considerable level of lipid peroxidation is involved in acute brucellosis cases and this may be of importance with respect to the understanding of disease pathogenesis and may serve as a target for treatment regime.
Kilic
N
N
Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey.
Ozden
M
M
Kalkan
A
A
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001799:Blood Sedimentation; D002006:Brucellosis / Q000188:drug therapy / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D011446:Prospective Studies; D012293:Rifampin / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use
D008315:Malondialdehyde; D002097:C-Reactive Protein; D004318:Doxycycline; D012293:Rifampin; D013307:Streptomycin