Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease.
The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and pharmacological relevance in the cardiovascular system. The complex mechanisms of regulation of GRK expression, degradation and function are being unveiled gradually. The levels of these kinases are known to change in pathological situations such as heart failure, hypertrophy and hypertension, and in animal models of these diseases. A better understanding of the mechanisms underlying these changes and of how these alterations participate in the triggering or progression of cardiovascular disease may contribute to the design of novel diagnostic and therapeutic strategies.
Penela
Petronila
P
Departamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Murga
Cristina
C
Ribas
Catalina
C
Tutor
Antonio S
AS
Peregrín
Sandra
S
Mayor
Federico
F
D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology* / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D051552:beta-Adrenergic Receptor Kinases / Q000378:metabolism*
D007527:Isoenzymes; D043562:Receptors, G-Protein-Coupled; D051552:beta-Adrenergic Receptor Kinases