Reactivity of the cerebral resistance and capacitance vessels and blood-brain water exchange in the experimental brain injury.
In conclusion, an estimate of the intracranial volumetric effects produced in anesthetized dogs by histamine, acetylcholine and CO2 shows that, on a basis of equiactivity on CBF, the effects of histamine on the intracranial content are twice greater than those produced by acetylcholine and CO2. This difference may be explained by a greater activity of histamine on the intracranial capacitance vessels and/or by an increase in the fluid escape from blood to the brain produced by histamine. Data obtained after the production of an acute, cold induced brain lesion support the second possibility.
Carpi
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A
Department of Therapeutical Chemistry, Istituto Superiore di Sanità, Roma.
Giardini
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V
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology*; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D003080:Cold Temperature; D004285:Dogs; D006632:Histamine / Q000494:pharmacology; D006935:Hypercapnia / Q000503:physiopathology; D018924:Vascular Capacitance / Q000502:physiology
D006632:Histamine; D000109:Acetylcholine