Four unusual two-component signal transduction homologs, RedC to RedF, are necessary for timely development in Myxococcus xanthus.
We identified a cluster of four two-component signal transduction genes that are necessary for proper progression of Myxococcus xanthus through development. redC to redF mutants developed and sporulated early, resulting in small, numerous, and disorganized fruiting bodies. Yeast two-hybrid analyses suggest that RedCDEF act in a single signaling pathway. The previously identified espA gene displays a phenotype similar to that of redCDEF. However, combined mutants defective in espA redCDEF exhibited a striking additive developmental phenotype, suggesting that EspA and RedC to RedF play independent roles in controlling developmental progression.
Higgs
Penelope I
PI
Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3204, USA.
Cho
Kyungyun
K
Whitworth
David E
DE
Evans
Lisa S
LS
Zusman
David R
DR
D000595:Amino Acid Sequence; D005798:Genes, Bacterial; D000071677:Histidine Kinase; D008969:Molecular Sequence Data; D005810:Multigene Family; D009154:Mutation; D016941:Myxococcus xanthus / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D011494:Protein Kinases / Q000235:genetics; D016415:Sequence Alignment; D015398:Signal Transduction / Q000235:genetics*; D013170:Spores / Q000254:growth & development
D011494:Protein Kinases; D000071677:Histidine Kinase