[The relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitro].
OBJECTIVE
To study the relaxants effects of six extractions from Chinese Herbs (neferine, tetrandrine, kakonein, scutellarin, ginsenoside Rgl and ginsenoside Rb1) on the corpus cavernosum tissue of rabbit in vitro.


METHODS
Isolated stripes of rabbit corpus cavernosum tissue were precontracted with 10(-5) mol/L phenylephrine (PE). Relaxation in response to cumulative doses of six extracts at (10(-8) - 10(-3)) mol/L was determined.


RESULTS
On rabbit cavernosal muscle stripes precontracted with PE, neferine, tetrandrine, kakonein and scutellarin showed dose dependent relaxation. IC50 values were 4.60 x 10(-6), 3.73 x 10(-5), 8.03 x 10(-4) and 3.33 x 10(-3) mol/L, respectively. However, in the meantime, it was found that the relaxant effects of ginsenoside Rgl and ginsenoside Rbl less significant to stripes precontracted with PE. When the final concentration was 10(-3) mol/L, the relaxations were only (16.32 +/- 5.45)% and (11.21 +/- 3.10)%.


CONCLUSIONS
Among the six extracts which showed relaxant effects to rabbit cavernosal muscle stripes precontracted with PE, neferine had greater functions than the other five extracts.
Chen
Jun
J
Department of Urology, Tongji Hospital, China.
Liu
Ji-hong
JH
Wang
Tao
T
Wang
Shao-gang
SG
Yin
Chun-ping
CP
Xiao
Heng-jun
HJ
Liu
Bo
B
Yang
Jun
J
Chen
Xiao-wen
XW
Ye
Zhang-qun
ZQ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010413:Penis / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits
D004365:Drugs, Chinese Herbal