title: Acid acclimation by Helicobacter pylori.
abstract: Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
authors.affiliation: Laboratory of Membrane Biology, David Geffen School of Medicine at the University of California-Los Angeles, USA. gsachs@ucla.edu
authors.forename: George
authors.initials: G
authors.lastname: Sachs
authors.forename: David L
authors.initials: DL
authors.lastname: Weeks
authors.forename: Yi
authors.initials: Y
authors.lastname: Wen
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Marcus
authors.forename: David R
authors.initials: DR
authors.lastname: Scott
authors.forename: Klaus
authors.initials: K
authors.lastname: Melchers
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D014510:Urease / Q000378:metabolism
chemical_list: D014510:Urease