Quinone bioreductive prodrugs as delivery agents.
Quinone bioreductive prodrugs were developed to target the hypoxic or the reductase- rich population of solid tumours. The mechanism of their selective activation is based on their ability to convert the quinone sub-structure to their activated semiquinone or hydroquinone species affording the active species. Recent studies on their biochemical activation process have resulted in their development as delivery agents that can effectively release a potent (but not necessarily a cytotoxic) agent under hypoxic/reductive conditions. This technology platform is currently being used to design/identify, and synthesise novel quinone bioreductive delivery agents to target cancer and other diseases where hypoxia and/or reductive enzymes play a major pathophysiological role.
Jaffar
Mohammed
M
School of Pharmacy and Pharmaceutical Sciences, University of Manchester Oxford Road, Manchester M13 9PL, UK. jaff@man.ac.uk
Abou-Zeid
Nathalie
N
Bai
Li
L
Mrema
Ibrahim
I
Robinson
Ian
I
Tanner
Richard
R
Stratford
Ian J
IJ
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D010084:Oxidation-Reduction; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D011809:Quinones / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*
D000970:Antineoplastic Agents; D011355:Prodrugs; D011809:Quinones