title: Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy.
abstract: GABA(B) receptor1 (GABA(B)R1) gene is one of the susceptibility genes for temporal lobe epilepsy (TLE). Recently, it is reported that the GABA(B)R1 polymorphism (G1465A) conferred a highly increased susceptibility to TLE. We performed a case-control study to confirm the findings. The study included a total of 112 nonlesional TLE patients and 124 controls of Chinese ancestry. Our study did not show any polymorphism in this locus, and suggested this polymorphism may not be a strong susceptibility factor for TLE among Chinese population.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Beijing, PR China.
authors.forename: Liankun
authors.initials: L
authors.lastname: Ren
authors.forename: Liri
authors.initials: L
authors.lastname: Jin
authors.forename: Boyu
authors.initials: B
authors.lastname: Zhang
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Jia
authors.forename: Liwen
authors.initials: L
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D044382:Population Groups; D018080:Receptors, GABA-B / Q000235:genetics*
chemical_list: D018080:Receptors, GABA-B