title: Acute hyperkalemic paralysis in a uremic patient.
abstract: Hyperkalemia is a less-recognized life-threatening cause of paralysis. We describe a 38-year-old uremic man on regular hemodialysis (HD) without interruption who suffered from muscle weakness progressing to ascending symmetric paralysis, and inability to masticate. Physical examination revealed flaccid paralysis with areflexia of the four limbs. Computed tomography of the brain and cervical spine did not demonstrate any organic lesions. Laboratory investigations revealed serum K+ 8.1 mmol/L, urea nitrogen 32 mmol/L, creatinine 919 micromol/L. Of note, electrocardiography (ECG) did not show typical features of hyperkalemia. Emergent HD with low K+ dialysate (1.0 mmol/L) rapidly normalized serum K+ (4.7 mmol/L) and reversed all neuromuscular symptoms within one hour. Upon reviewing his food and medication history, he admitted drinking 750 ml of raw coconut juice per day (K+ concentration 44.3 mmol/L) to quench his thirst for three consecutive days. Hyperkalemia should be born in mind in the differential diagnosis of acute paralysis despite no ECG changes. Hidden sources of K+ intake, such as coconut juice, should not be overlooked, especially in patients with impaired renal function.
authors.affiliation: Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei--Taiwan.
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Cheng
authors.forename: Jainn-Shiun
authors.initials: JS
authors.lastname: Chiu
authors.forename: Wei-Hsin
authors.initials: WH
authors.lastname: Huang
authors.forename: Shih-Hua
authors.initials: SH
authors.lastname: Lin
mesh_terms: D000328:Adult; D001628:Beverages / Q000009:adverse effects; D003059:Cocos / Q000009:adverse effects; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced / Q000150:complications*; D008297:Male; D010243:Paralysis / Q000209:etiology*; D006435:Renal Dialysis; D014511:Uremia / Q000150:complications* / Q000628:therapy