[Immunopathogenesis of psoriasis].
Psoriasis is a chronic inflammatory disease of the skin and the joints. Multiple factors contribute to the initiation of psoriasis. They include specific genetic characteristics such as major histocompatibility antigens and psoriasis susceptibility genes, as well as trigger factors, namely streptococcal infections. Today, psoriasis is considered as a T-lymphocyte mediated autoimmune disease, even though the putative autoantigen remains unknown. Bacterial proteins with similarity to structural proteins of keratinocytes are potential target antigens. As in other autoimmune diseases, inflammatory cytokines of the innate immune system initiate a cascade that activates inflammation locally in the skin, in the circulation and most likely also in lymph nodes. IFN-gamma-producing CD4+ Th1-lymphocytes seem to be of central importance in the pathogenesis of psoriasis as they critically influence differentiation and functioning of antigen presenting cells, mast cells, neutrophils and endothelial cells. This inflammatory cascade simultaneously provokes neoangiogenesis in the dermis and proliferation of keratinocytes. Based on this hypothesis, cytokines or anticytokine antibodies that either inhibit T-cell mediated inflammation or transform disease-inducing, pro-inflammatory Th1-lymphocytes into a phenotype with anti-inflammatory properties were tested in psoriasis. As both approaches improved psoriasis, they strongly support the current concept that views psoriasis as a Th1-lymphocyte mediated disease.
Ghoreschi
Kamran
K
Universitäts-Hautklinik, Eberhard Karls Universität Tübingen. Kamran.Ghoreschi@med.uni-tuebingen.de
Röcken
Martin
M
D015535:Arthritis, Psoriatic / Q000235:genetics / Q000276:immunology*; D001323:Autoantibodies / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology; D007125:Immunogenetics; D007596:Joints / Q000276:immunology; D011565:Psoriasis / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors; D012867:Skin / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology
D001323:Autoantibodies; D016207:Cytokines; D000939:Epitopes