Synthesis and biological activity of novel acyclic versions of Neplanocin A.
Novel acyclic Neplanocin A analogues were designed and synthesized. The coupling of the alkyl bromide with nucleosidic bases (T, U, 5-FU, 5-IU, C, A) and desilylation afforded a series of novel acyclic nucleosides. The synthesized compounds were evaluated for their antiviral and antitumor activity.
Wu
Ying
Y
College of Pharmacy, Chosun University, Kwangju, Republic of Korea.
Hong
Joon Hee
JH
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; C031096:neplanocin A; D000241:Adenosine