title: Contrasting clinical and cardiovascular risk status between early and later onset type 2 diabetes.
abstract: The prevalence of type 2 diabetes (T2DM) is increasing rapidly and the age of presentation is falling. These changes are likely to be linked to the current obesity epidemic. Our objective was to compare the characteristics of younger patients with T2DM (diagnosed at age < 40 years) with those of older patients (diagnosed at age 50-70 years). We identified 149 younger patients with T2DM, from our diabetes clinic database, and compared them with 217 older T2DM patients randomly identified from the same database. Younger patients with T2DM were more obese, more hypertriglyceridaemic, with lower high-density lipoprotein (HDL) cholesterol, higher total cholesterol/HDL ratio and worse initial and ongoing glycaemic control than older patients from the same clinic. Additional cardiovascular risk factors are associated with T2DM in the young. Treatment should be aimed at early modification of lifestyle and other forms of therapy to avoid long-term complications.
authors.affiliation: Metabolic Research Unit, Hospital 5, St James's Hospital, Dublin 8, Ireland.
authors.forename: Mensud
authors.initials: M
authors.lastname: Hatunic
authors.forename: Nicole
authors.initials: N
authors.lastname: Burns
authors.forename: Francis
authors.initials: F
authors.lastname: Finucane
authors.forename: Cynthia
authors.initials: C
authors.lastname: Mannion
authors.forename: John J
authors.initials: JJ
authors.lastname: Nolan
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides
chemical_list: D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D014280:Triglycerides