Neurosis-associated changes in the granulocytic hemopoietic stem in mice with different learning capacity.
We studied the local mechanisms of neurosis-associated changes in the granulocytic hemopoietic stem in CBA/CaLac mice with different learning capacity. It was found that in good learners hyperplasia of the bone marrow granulocytopoiesis during neurosis was related to enhanced proliferative activity and accelerated maturation of granulocyte-macrophage precursors resulting from increased formation of granulocytic and erythrogranulocytic hemopoietic islets. In poor learners primary suppression of the bone marrow granulocytopoiesis was associated with impaired formation of hemopoietic islets (conflict situation) and inhibition of differentiation of granulocyte-macrophage precursors (paradoxical sleep deprivation followed by T-maze learning). Then, recovered ability of bone marrow cells to form granulocyte complexes even against the background of inhibition of precursor differentiation (conflict situation) and accelerated maturation of granulocytic cells (paradoxical sleep deprivation and maze learning) lead to hyperplasia of the granulocytic hemopoietic stem.
Skurikhin
E G
EG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.
Pershina
O V
OV
Stavrova
L A
LA
Suslov
N I
NI
Minakova
M Yu
MY
Dygai
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000378:metabolism; D006098:Granulocytes / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System; D006965:Hyperplasia / Q000473:pathology; D007858:Learning; D008264:Macrophages / Q000378:metabolism; D018782:Maze Learning; D051379:Mice; D008808:Mice, Inbred CBA; D015233:Models, Statistical; D019964:Mood Disorders / Q000097:blood; D013234:Stem Cells; D013997:Time Factors