Influence of experimentally induced anxiety on gastric sensorimotor function in humans.
OBJECTIVE
Unexplained dyspeptic symptoms are associated with changes in gastric sensorimotor function and several psychopathologic dimensions, including anxiety. It is unclear whether this reflects common predisposition or a causal relationship. The aim of this study was to investigate whether experimentally induced anxiety would alter gastric sensorimotor function in health.


METHODS
Fourteen subjects underwent a gastric barostat study to assess gastric sensitivity and accommodation. Eighteen subjects underwent a 10-minute satiety drinking test (30 mL/min) with registration of epigastric symptoms on a visual analogue scale (VAS) at 2-minute intervals. Emotional context was modulated for 10 minutes at the start of each experiment by combined projection of validated facial expressions and an audiotape recalling a neutral or an anxious autobiographical experience. Anxiety levels were assessed using a VAS and the Spielberger State-Trait Anxiety Inventory (STAI).


RESULTS
VAS and STAI scores confirmed efficacy of anxiety induction. During the anxiety condition, gastric compliance was significantly decreased (57 +/- 5 vs 40 +/- 5 mL/mm Hg; P < .01). Intraballoon pressures inducing discomfort during gastric distention were not altered, but the corresponding volume (630 +/- 47 vs 489 +/- 39 mL; P < .005) was significantly lower. Meal-induced relaxation was inhibited during the anxiety condition and this persisted for the 60-minute measurement (157 +/- 29 vs 100 +/- 24 mL; P < .05). During the satiety drinking test, the anxiety condition was associated with significantly higher scores for satiety, fullness, and bloating.


CONCLUSIONS
Experimentally induced anxiety alters gastric sensorimotor function, suggesting that psychological factors may play a causal role in the pathogenesis of some dyspeptic symptoms and mechanisms.
Geeraerts
Brecht
B
Center for Gastroenterological Research, Leuven, Belgium.
Vandenberghe
Joris
J
Van Oudenhove
Lukas
L
Gregory
Lloyd J
LJ
Aziz
Quasim
Q
Dupont
Patrick
P
Demyttenaere
Koen
K
Janssens
Jozef
J
Tack
Jan
J
D000328:Adult; D001007:Anxiety / Q000503:physiopathology*; D004415:Dyspepsia / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology*; D004435:Eating; D005215:Fasting / Q000502:physiology / Q000523:psychology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D011312:Pressure; D013270:Stomach / Q000294:innervation* / Q000502:physiology*