title: Anti-hyperglycemic effects of plum in a rat model of obesity and type 2 diabetes, Wistar fatty rat.
abstract: Dried plums, considered a healthy food in the West and used as medicine in India, contain phenolic compounds with protective actions against age-related diseases. Effects of oral plum ekisu (concentrated juice) on lipid and glucose tolerance were assessed in insulin-resistant obese Wistar fatty rats. Plum ingestion decreased blood glucose (P < 0.05) and plasma triglyceride concentrations (P < 0.01) compared with controls. Plum treatment for 2 weeks reduced areas under the curve (AUCs) for glucose and insulin during a glucose tolerance test. In db/db mice, plum decreased these AUCs, and also blood glucose during an insulin tolerance test. Plum treatment significantly increased plasma adiponectin concentrations and PPARgamma mRNA expression in adipose tissue from Wistar fatty rats. Plum thus may increase insulin sensitivity in these rats via adiponectin-related mechanisms.
authors.affiliation: Department of Pathology, Wakayama Medical University, Wakayama, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Utsunomiya
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamakawa
authors.forename: Junzo
authors.initials: J
authors.lastname: Kamei
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kadonosono
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004435:Eating; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008055:Lipids / Q000097:blood; D051379:Mice; D009765:Obesity / Q000378:metabolism*; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D027861:Prunus / Q000737:chemistry*; D051381:Rats; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D011924:Rats, Zucker; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D047493:PPAR alpha; D047495:PPAR gamma; D010936:Plant Extracts; D051780:Sterol Regulatory Element Binding Protein 1