Anemia and erythropoietin in space flights.
Since the very early manned missions in space, a state of anemia associated with reduced erythropoietin levels and reduced plasma volume was disclosed. The reduction in red blood cell mass is driven by a process of selective hemolysis, which has been named neocytolysis. This phenomenon also occurs in people living at a high altitude who descend rapidly to sea level. The origin of the signal leading to destruction of newly produced red blood cells probably is located in central circulation, but the operating mechanism is unknown. The importance of plasma cell volume reduction in the genesis of a lower red cell mass also is supported by the inverse correlation seen at moderate altitude. People arriving at moderate altitude have increased erythropoietin concentration that decreases after a few days and is in inverse correlation with central venous pressure. Studies under simulated microgravity conditions in human beings (bed rest, head-down tilt at -6 degrees , water immersion) and in rats provide further insight in unraveling the mechanism of astronauts' anemia, a problem difficult to study in space because of the limited availability of spaceflights.
De Santo
Natale G
NG
Second University of Naples, Naples, Italy. nataleg.desanto@unina2.it
Cirillo
Massimo
M
Kirsch
Karl A
KA
Correale
Giacomo
G
Drummer
Christian
C
Frassl
Waltraud
W
Perna
Alessandra F
AF
Di Stazio
Enzo
E
Bellini
Luigi
L
Gunga
Hanns-Christian
HC
D000740:Anemia / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D016022:Case-Control Studies; D002468:Cell Physiological Phenomena; D004905:Erythrocyte Aging; D004920:Erythropoiesis / Q000502:physiology*; D004921:Erythropoietin / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D018475:Head-Down Tilt; D006801:Humans; D015994:Incidence; D008297:Male; D023421:Models, Animal; D051381:Rats; D012106:Research; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*
D004921:Erythropoietin