Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese.
OBJECTIVE
To investigate the association of CYP2C9*3 and *6 with hyperlipidaemia in Chinese.


METHODS
Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9*3 and *6.


RESULTS
CYP2C9*6 was not detected in this study. The allelic frequency of CYP2C9*3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9*3 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls (P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9*3 frequency in patients with hyperlipidaemia was significantly lower than that in controls (P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476).


CONCLUSIONS
The association of CYP2C9*3 with hyperlipidaemia was specific for females in this Chinese population.
Luo
Chen-Hui
CH
Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, China.
Wang
An
A
Zhu
Rong-Hua
RH
Zhang
Wei-Xia
WX
Mo
Wei
W
Yu
Bang-Ning
BN
Chen
Guo-Lin
GL
Ou-Yang
Dong-Sheng
DS
Duan
Xiao-Hong
XH
Abd El-Aty
A M
AM
Zhou
Hong-Hao
HH
D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D012727:Sex Characteristics
C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases