Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.
Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two independent groups. These studies demonstrated that alleles at markers in the mitogen-activating protein kinase 7 interacting protein 2 (MAP3K7IP2)/SUMO4 region were associated with susceptibility to type 1 diabetes. Subsequent studies, however, showed inconsistency in the association of the SUMO4 gene with type 1 diabetes. To clarify the contribution of the M55V polymorphism of the SUMO4 gene to type 1 diabetes susceptibility, 541 type 1 diabetic patients and 768 control subjects were studied in Asian populations. The M55V polymorphism was significantly associated with type 1 diabetes in Asian populations (summary odds ratio [OR] 1.46, P = 0.00083, Mantel-Haenszel test). Meta-analysis of published studies and the present data confirmed a highly significant association in Asian populations (summary OR 1.29, P = 7.0 x 10(-6)) but indicated heterogeneity in the genetic effect of the SUMO4/MAP3K7IP2 locus on type 1 diabetes among diverse ethnic groups. These data indicate that the MAP3K7IP2/SUMO4 locus in the IDDM5 interval is associated with type 1 diabetes in Asian populations.
Noso
Shinsuke
S
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, Japan.
Ikegami
Hiroshi
H
Fujisawa
Tomomi
T
Kawabata
Yumiko
Y
Asano
Katsuaki
K
Hiromine
Yoshihisa
Y
Tsurumaru
Masako
M
Sugihara
Shigetaka
S
Lee
Inkyu
I
Kawasaki
Eiji
E
Awata
Takuya
T
Ogihara
Toshio
T
D044466:Asian People / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007564:Japan; D007723:Korea; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics
C489647:SUMO4 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins