title: Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).
abstract: An efficient method for the synthesis of 7-deazaneplanocin A (2) has been accomplished by the condensation of cyclopentenol 3 with 6-chloro-7-deazapurine followed by subsequent functional group manipulations. The synthesized 7-deazaneplanocin A (2) exhibited potent antiviral activity against cowpox and vaccinia viruses without cytotoxicity in HFF cells.
authors.affiliation: University of Georgia College of Pharmacy, Athens, GA 30602, USA.
authors.forename: Balakumar
authors.initials: B
authors.lastname: Arumugham
authors.forename: Hyo-Joong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Mark N
authors.initials: MN
authors.lastname: Prichard
authors.forename: Earl R
authors.initials: ER
authors.lastname: Kern
authors.forename: Chung K
authors.initials: CK
authors.lastname: Chu
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D018155:Orthopoxvirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: C508195:7-deazaneplanocin A; D000998:Antiviral Agents; D000241:Adenosine