Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis.
Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage-gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage-gated potassium channel antibody-associated limbic encephalitis onset. In three patients, immunosuppression resulted in resolution of RBD in parallel with remission of the limbic syndrome. RBD persisted in two patients with partial resolution of the limbic syndrome. Our findings suggest that RBD is frequent in the setting of voltage-gated potassium channel antibody-associated limbic encephalitis and can be related to autoimmune-mediated mechanisms. In addition, these observations suggest that impairment of the limbic system may play a role in the pathogenesis of RBD.
Iranzo
Alex
A
Neurology Service, Hospital Clínic and Institut d'Investigació Biomèdiques August Pi i Sunyer, C/Villaroel 170, 08036 Barcelona, Spain. airanzo@clinic.ub.es
Graus
Francesc
F
Clover
Linda
L
Morera
Jaume
J
Bruna
Jordi
J
Vilar
Carlos
C
Martínez-Rodriguez
José Enrique
JE
Vincent
Angela
A
Santamaría
Joan
J
D000368:Aged; D000906:Antibodies / Q000276:immunology*; D004569:Electroencephalography; D004576:Electromyography; D006801:Humans; D020363:Limbic Encephalitis / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D020187:REM Sleep Behavior Disorder / Q000209:etiology / Q000276:immunology / Q000503:physiopathology
D000906:Antibodies; D024642:Potassium Channels, Voltage-Gated