Synthesis, structure and anti-acetylcholinesterase activity of 4beta-methoxymethyl-4beta-demethyl territrem B.
4beta-Methoxymethyl-4beta-demethyl territrem B [5] was synthesized from 4beta-hydroxymethyl-beta-demethyl territrem B [4] by treatment with dimethyl sulfate in methanolic NaOH. The structure of 5 was elucidated by uv, nmr and mass spectra. The IC50 of 5 on acetylcholinesterase (AChE) was 6.30 x 10(-5) M, which indicated 0.4% of the anti-AChE activity of territrem B [2].
Peng
F C
FC
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Cheng
J S
JS