title: Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese.
abstract: OBJECTIVE
  To investigate the association of CYP2C9*3 and *6 with hyperlipidaemia in Chinese.
  
  
  METHODS
  Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9*3 and *6.
  
  
  RESULTS
  CYP2C9*6 was not detected in this study. The allelic frequency of CYP2C9*3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9*3 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls (P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9*3 frequency in patients with hyperlipidaemia was significantly lower than that in controls (P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476).
  
  
  CONCLUSIONS
  The association of CYP2C9*3 with hyperlipidaemia was specific for females in this Chinese population.
authors.affiliation: Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, China.
authors.forename: Chen-Hui
authors.initials: CH
authors.lastname: Luo
authors.forename: An
authors.initials: A
authors.lastname: Wang
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Zhu
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Mo
authors.forename: Bang-Ning
authors.initials: BN
authors.lastname: Yu
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Chen
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Ou-Yang
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Duan
authors.forename: A M
authors.initials: AM
authors.lastname: Abd El-Aty
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D012727:Sex Characteristics
chemical_list: C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases