title: Perioperative risk factors for anastomotic leakage after esophagectomy: influence of thoracic epidural analgesia.
abstract: OBJECTIVE
  Anastomotic leakage after esophagectomy is associated with high postoperative morbidity and mortality. The most important predisposing factors for anastomotic leaks are ischemia of the gastric conduit and low blood oxygen content. The aim of this study was to evaluate the influence of thoracic epidural analgesia (TEA) on the incidence of anastomotic leakage after esophagectomy.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A thoracic surgery and anesthesia department in a teaching hospital.
  
  
  METHODS
  Two hundred seven patients who underwent one-stage esophagectomy between 1998 and 2003.
  
  
  METHODS
  The effects of perioperative factors and postoperative complications on the incidence of anastomotic leakage were analyzed. Leakage was defined as an anastomotic disruption detected by an ionic x-ray contrast study and confirmed by upper endoscopy in the postoperative period. Analyzed factors included effective TEA placed before the surgical procedure.
  
  
  RESULTS
  Anastomotic leakage occurred in 23 patients (11%). This complication was associated with a significant increase in length of stay in the ICU and in the hospital (mean, 19 +/- 16 days vs 9 +/- 7 days [+/- SD], p = 0.008; and 43 +/- 27 days vs 23 +/- 11 days, respectively; p < 0.001). Mortality in patients presenting anastomotic leakage was 26%, compared with 5.4% in the remainder (p = 0.002). Factors independently associated with the incidence of leakage included estimated blood loss per milliliter during the surgical procedure (odds ratio [OR], 1.004; 95% confidence interval [CI], 1.001 to 1.007), the cervical location for anastomosis (OR, 5.4; 95% CI, 1.3 to 22.9), and the development of an ARDS in the postoperative period (OR, 4.1; 95% CI, 2.6 to 176.5). Ninety-three patients benefited from an effective TEA for 4.4 +/- 0.8 days. The use of TEA was independently associated with a decrease in the incidence of anastomotic leakage (OR, 0.13; 95% CI, 0.02 to 0.71).
  
  
  CONCLUSIONS
  The results of this retrospective study suggest that TEA is associated with a decrease in occurrence of anastomotic leakage.
authors.affiliation: Département d'Anesthésie Réanimation, Marseille, France. pierre.michelet@mail.ap-hm.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Michelet
authors.forename: Xavier-Benoit
authors.initials: XB
authors.lastname: D'Journo
authors.forename: Antoine
authors.initials: A
authors.lastname: Roch
authors.forename: Laurent
authors.initials: L
authors.lastname: Papazian
authors.forename: Jacques
authors.initials: J
authors.lastname: Ragni
authors.forename: Pascal
authors.initials: P
authors.lastname: Thomas
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Auffray
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000368:Aged; D015360:Analgesia, Epidural; D000714:Anastomosis, Surgical; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D016015:Logistic Models; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D010100:Oxygen