The role of stress in ageing: research on the nematode, Caenorhabditis elegans.
The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging and the roles of stress. In this review we focus on the genetics of select long-lived and short-lived mutants of C. elegans that have proven useful in revealing the relationships that exist between oxidative stress and life span. The former are known to be controlled by an insulin/insulin-like signaling pathway, while the latter are affected by mitochondrial functions.
Ishii
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Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan. nishii@is.icc.u-tokai.ac.jp
D000375:Aging / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000235:genetics; D017238:Genes, Helminth; D007328:Insulin / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D023421:Models, Animal; D009154:Mutation; D018384:Oxidative Stress / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D007328:Insulin