Postinfectious myeloradiculoneuropathy with cranial nerve involvements associated with human herpesvirus 7 infection.
BACKGROUND
Infection with human herpesvirus 7 (HHV-7) generally results in a febrile illness with accompanying exanthema subitum.


OBJECTIVE
To ascertain and describe the role of HHV-7 in a case of acute myeloradiculoneuropathy.


METHODS
A previously healthy young man with complaints of motor weakness, dysphasia, and nasal voice.


METHODS
Serological examinations were performed with the patient's serum. We also examined virus genome DNA in cerebrospinal fluid by regular and real-time polymerase chain reaction. Moreover, we checked the antiganglioside antibody level in the patient's serum samples by the immunoblot analysis.


RESULTS
Serological studies revealed significant change in titers of antibodies against cytomegalovirus, Epstein-Barr virus, and HHV-7, but only HHV-7 genome was detected in the cerebrospinal fluid, with its disappearance after therapy. No antiganglioside antibody was detected in the patient's serum.


CONCLUSIONS
The unique clinical picture of the present patient might be closely related to the reactivation of HHV-7 in the nervous system.
Mihara
Takateru
T
Department of Neurology, Fujita Health University School of Medicine, Aichi, Japan.
Mutoh
Tatsuro
T
Yoshikawa
Tetsusi
T
Yano
Shigeaki
S
Asano
Yoshizo
Y
Yamamoto
Hiroko
H
D000328:Adult; D003391:Cranial Nerves / Q000473:pathology / Q000503:physiopathology* / Q000821:virology*; D004279:DNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid / Q000150:complications*; D016199:Herpesvirus 7, Human; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D003294:Seizures, Febrile / Q000150:complications* / Q000821:virology
D004279:DNA, Viral; D012333:RNA, Messenger