title: Low-fluoride dentifrice and gastrointestinal fluoride absorption after meals.
abstract: A low-fluoride (F) dentifrice has been recommended to reduce the risk of dental fluorosis, but its anti-caries efficacy is questionable compared with that of conventional dentrifices (1000-1100 microg F/g). The tested hypothesis was that conventional dentifrices might be safe if used soon after meals, since food interferes with F absorption. In a crossover, double-blind study, 11 volunteers ingested a dentifrice slurry containing 0 (placebo), 550 (low F), or 1100 microg F/g in 3 gastric content situations: on fasting, or 15 min after breakfast or lunch. F was analyzed in saliva and 24-hour urine samples. The conventional dentifrice ingested after lunch resulted in only 10% higher F absorption than the low-F ingested on fasting. Analysis of the data suggests that the risk of fluorosis could be reduced by the use of either a low-F dentifrice or a conventional dentifrice, if toothbrushing occurred soon after meals.
authors.affiliation: Faculty of Dentistry of Piracicaba, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil. jcury@fop.unicamp.br
authors.forename: J A
authors.initials: JA
authors.lastname: Cury
authors.forename: F S
authors.initials: FS
authors.lastname: Del Fiol
authors.forename: L M A
authors.initials: LM
authors.lastname: Tenuta
authors.forename: P L
authors.initials: PL
authors.lastname: Rosalen
mesh_terms: D000042:Absorption; D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D002327:Cariostatic Agents / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D003802:Dentifrices / Q000008:administration & dosage*; D004311:Double-Blind Method; D004435:Eating; D005215:Fasting; D005260:Female; D005459:Fluorides / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000652:urine; D005766:Gastrointestinal Contents; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D008297:Male; D010919:Placebos; D012463:Saliva / Q000737:chemistry
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D010919:Placebos; D005459:Fluorides