title: Chemical synthesis approaches to the engineering of ion channels.
abstract: Chemoselective ligation strategies have previously provided synthetic access to water-soluble proteins with novel properties, and more recently these strategies have been used to prepare ion channels. Examples of ion channels prepared by total chemical synthesis include bacterial mechanosensitive channels, and viral ion channels. Chemical protein synthesis allows for the generation of ion channel proteins with both native, and engineered structural or conductance properties.
authors.affiliation: Gryphon Therapeutics, 600 Gateway Boulevard, South San Francisco, CA 94080, USA. gerd@gryphonrx.com
authors.forename: Gerd G
authors.initials: GG
authors.lastname: Kochendoerfer
authors.forename: Daniel
authors.initials: D
authors.lastname: Clayton
authors.forename: Christian
authors.initials: C
authors.lastname: Becker
mesh_terms: D000818:Animals; D029968:Escherichia coli Proteins / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D007473:Ion Channels / Q000138:chemical synthesis* / Q000737:chemistry; D008565:Membrane Proteins / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D015202:Protein Engineering / Q000379:methods*
chemical_list: D029968:Escherichia coli Proteins; D007473:Ion Channels; D008565:Membrane Proteins; C086596:MscL protein, E coli; D010455:Peptides