title: Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy.
abstract: OBJECTIVE
  To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans.
  
  
  METHODS
  This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects.
  
  
  RESULTS
  Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects.
  
  
  CONCLUSIONS
  These rates provide a benchmark that can be used to monitor future treatment response in PSP.
authors.affiliation: Department of Neurology, Mayo Clinic, 200 First Street NW, Rochester, MN 55905, USA. josephs.keith@mayo.edu
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Whitwell
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.forename: Maria M
authors.initials: MM
authors.lastname: Shiung
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Gunter
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Parisi
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000473:pathology*; D001344:Autopsy; D002540:Cerebral Cortex / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*