title: [Imiquimod for the topical treatment of focal epithelial hyperplasia (Heck disease) in a child].
abstract: Focal epithelial hyperplasia (FEH) or Heck disease is a rare skin disease caused by human papilloma viruses (HPV). The case of a 9-year old boy is presented to demonstrate the successful treatment of massive FEH with 5% imiquimod cream. Initially, the patient had noticed several separate papules, which spread and developed into multiple peri- and intraoral papillomatous nodules. The lesions were treated with carbon dioxide laser destruction. However, multiple, skin-coloured papillomatous nodules were found on the tongue, buccal mucosa and lips 1.5 years later. Treatment with imiquimod was initiated, because the patient suffered tremendously from the disease. 5% imiquimod cream was applied 3 times per week. Regression of lesions was obvious after 1 month of treatment. Complete clearance was achieved after 2 additional months of treatment and no recurrence was detected over a follow-up period of 5 months. Our case points out the clinical value of imiquimod for the non-traumatic and almost painless therapy of HPV-induced skin diseases in children.
authors.affiliation: Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen. janmaschke@web.de
authors.forename: Jan
authors.initials: J
authors.lastname: Maschke
authors.forename: Tilmann C
authors.initials: TC
authors.lastname: Brauns
authors.forename: Manfred
authors.initials: M
authors.lastname: Goos
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage*; D002648:Child; D003879:Dermatologic Agents / Q000008:administration & dosage*; D017573:Focal Epithelial Hyperplasia / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D000077271:Imiquimod; D008297:Male; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D003879:Dermatologic Agents; D000077271:Imiquimod