title: A congenital brain tumor associated with assisted in vitro fertilization. Case report.
abstract: In this report the authors describe the clinical features of a rare neonatal anaplastic astrocytoma in the setting of in vitro fertilization (IVF). The infant had been conceived using IVF and was born full term to a 29-year-old prima gravida mother. At birth, the baby boy was irritable and demonstrated poor feeding. Cranial ultrasonography and magnetic resonance imaging revealed an echogenic mass in the left hemisphere with midline shift and hydrocephalus. Grosstotal resection of an anaplastic astrocytoma was followed by chemotherapy with temozolomide and vincristine. Previous cases of neonatal brain tumors occurring in the setting of assisted reproduction are reviewed. A possible association between IVF and congenital neuroepithelial tumors is highlighted.
authors.affiliation: Maxine Dunitz Neurosurgical Institute, USA. Asha_Das@eisai.com
authors.forename: Asha
authors.initials: A
authors.lastname: Das
authors.forename: Charles
authors.initials: C
authors.lastname: Simmons
authors.forename: Moise
authors.initials: M
authors.lastname: Danielpour
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001254:Astrocytoma / Q000151:congenital* / Q000188:drug therapy / Q000601:surgery; D001932:Brain Neoplasms / Q000151:congenital* / Q000188:drug therapy / Q000601:surgery; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D000077204:Temozolomide; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003606:Dacarbazine; D000077204:Temozolomide