title: Unusually sulfated and oxygenated steroids from Withania somnifera.
abstract: Four (1, 8-10) and six known (2-7) withanolides were isolated from the leaves of Withania somnifera. Among the new compounds, 10 possessed the rare 3-O-sulfate group with the saturation in A ring and 9 contained unusual 1,4-dien-3-one group. Compound 8 did not have usual 2,3 unsaturation in A ring while 1 had the rare C-16 double bond. The structures of all the compounds were elucidated by spectroscopic methods and chemical transformation.
authors.affiliation: Central Institute of Medicinal and Aromatic Plants, P.O.-CIMAP, Lucknow, UP 226 015, India. laxmisra@hotmail.com
authors.forename: Laxminarain
authors.initials: L
authors.lastname: Misra
authors.forename: Payare
authors.initials: P
authors.lastname: Lal
authors.forename: Rajender S
authors.initials: RS
authors.lastname: Sangwan
authors.forename: Neelam S
authors.initials: NS
authors.lastname: Sangwan
authors.forename: Girish C
authors.initials: GC
authors.lastname: Uniyal
authors.forename: Rakesh
authors.initials: R
authors.lastname: Tuli
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification; D013431:Sulfates / Q000737:chemistry*; D032341:Withania / Q000737:chemistry*
chemical_list: D013256:Steroids; D013431:Sulfates; D010100:Oxygen