Assignment of 101 genes localized in HSA10 to a swine RH (IMpRH) map to generate a dense human-swine comparative map.
Economically important traits such as growth and backfat in pigs have been shown to be influenced by genes in swine chromosome (SSC) 10q12-->qter corresponding to human chromosome (HSA) 10p. However, since gene information in the swine chromosomal region was limited, we attempted to generate a dense comparative map between SSC10 and HSA10 by mapping the 115 genes of HSA10 to a swine RH map (IMpRH map). In the mapping ten genes were assigned to SSC10, 88 to SSC14, and one to SSC3. One gene was suggested to link to SSC3, and another to SSC9. The correspondences between HSA10 and SSC10 and between HSA10 and SSC14 were essentially consistent with the observations obtained from bi/uni-directional chromosome painting or other results. This study further indicated that a large number of intrachromosomal rearrangements occurred in the synteny-conserved regions following species separation.
Yasue
H
H
Genome Research Department, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan. hyasue@affrc.go.jp
Kiuchi
S
S
Hiraiwa
H
H
Ozawa
A
A
Hayashi
T
T
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D017931:DNA Primers; D005819:Genetic Markers; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D013552:Swine / Q000235:genetics* / Q000254:growth & development
D017931:DNA Primers; D005819:Genetic Markers