title: Structure-activity relationships of dengue antiviral polycyclic quinones.
abstract: The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.
authors.affiliation: Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR152 IRD - Université Paul Sabatier, Centre IRD, Nouméa, Nouvelle-Calédonie, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurent
authors.forename: Francine
authors.initials: F
authors.lastname: Baumann
authors.forename: Anne Gaelle
authors.initials: AG
authors.lastname: Benoit
authors.forename: Alain
authors.initials: A
authors.lastname: Mortelecqe
authors.forename: Narong
authors.initials: N
authors.lastname: Nitatpattana
authors.forename: Isabelle
authors.initials: I
authors.lastname: Desvignes
authors.forename: Cécile
authors.initials: C
authors.lastname: Debitus
authors.forename: Manola
authors.initials: M
authors.lastname: Laille
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Gonzalez
authors.forename: Eliane
authors.initials: E
authors.lastname: Chungue
mesh_terms: D000818:Animals; D003716:Dengue Virus; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons; D011809:Quinones; D013329:Structure-Activity Relationship
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D011809:Quinones; C437338:gymnochrome A