title: [Effects of aggressive therapy with simvastatin in patients with acute coronary syndrome and initially normal level of LDLP cholesterol on cardiovascular outcomes (LAOKOON). Pilot randomized trial].
abstract: OBJECTIVE
  To examine anti-inflammatory effect of statins on outcomes of acute coronary syndrome (ACS).
  
  
  METHODS
  The trial included 211 ACS patients without ST elevation at ECG. The patients were followed up for 180 days. The anti-inflammatory action was studied for 30 days. The patients were divided into two groups by the treatment: simvastatin 10 mg + aspirin 325 mg (104 patients, group 1) and simvastatin 40 mg + aspirin 325 mg (107 patients, group 2) for 30 days.
  
  
  RESULTS
  Simvastatin in maximal dose lowed LDLP cholesterol from 101 +/- 9.8 to 72 +/- 3.3 mg/dl, in a minimal dose--from 104 +/- 11.3 to 81 +/- 2.1 mg/dl (p < 0.05). Only maximal dose simvastatin produced a significant reduction of C-reactive protein (CRP) to the disease day 14. The integral index including all cases of cardiovascular death +acute myocardial infarction+progressive angina+rehospitalization was 70 scores for group 1 and 137 for group 2 (p = 0.047).
  
  
  CONCLUSIONS
  Use of simvastatin in ACS patients, initially normal level of LDLP cholesterol and elevated level of CRP produced a dose-dependent effect, alleviated inflammation and improved the disease course.
authors.forename: G P
authors.initials: GP
authors.lastname: Arutiunov
authors.forename: T P
authors.initials: TP
authors.lastname: Kartseva
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Voevodina
authors.forename: I I
authors.initials: II
authors.lastname: Daĭter
authors.forename: R V
authors.initials: RV
authors.lastname: Malanichev
authors.forename: A A
authors.initials: AA
authors.lastname: Marfunina
authors.forename: V I
authors.initials: VI
authors.lastname: Nakhaev
authors.forename: A V
authors.initials: AV
authors.lastname: Rozanov
authors.forename: A K
authors.initials: AK
authors.lastname: Rylova
authors.forename: L V
authors.initials: LV
authors.lastname: Stepanova
mesh_terms: D000208:Acute Disease; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D019821:Simvastatin / Q000627:therapeutic use*; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein; D019821:Simvastatin; D001241:Aspirin