Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study.
Risk of incident dementia from any cause and Alzheimer's disease (AD) in relation to the IL-1beta-511 (C-->T) and IL-6-174 (G-->C) polymorphisms was investigated in an Italian elderly cohort (n=791) with 4 years of follow-up. Analyses were adjusted for socio-demographic confounders (age, gender, education), presence of the Apolipoprotein E-epsilon4 allele, and plasma total homocysteine (tHcy), a newly proposed AD risk factor. No significant association was found for the IL-1beta-511 and IL-6-174 polymorphisms with either dementia or AD. However, in the baseline dementia-free cohort considered as a whole, independently of other confounders, IL-1beta-511 T/T homozygotes had lower plasma tHcy than both heterozygotes (P=0.036) and wild-types (P=0.004). These data do not support the hypothesis that the IL-1-beta-511 and IL-6-174 polymorphisms affect dementia or AD risk. The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD.
Ravaglia
Giovanni
G
Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti, 9-40138 Bologna, Italy. ravaglia@med.unibo.it
Paola
Forti
F
Maioli
Fabiola
F
Martelli
Mabel
M
Montesi
Fausta
F
Bastagli
Luciana
L
Bianchin
Marisa
M
Chiappelli
Martina
M
Tumini
Emanuela
E
Bolondi
Luigi
L
Licastro
Federico
F
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D003704:Dementia / Q000097:blood / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D007375:Interleukin-1; D015850:Interleukin-6; D006710:Homocysteine