title: 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications.
abstract: H(2)O(2) is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H(2)O(2) generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H(2)O(2) reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H(2)O(2) signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.
authors.affiliation: Center for Cell Signaling Research and Division of Molecular Life Science, Ewha Womans University, Seoul 120-750, Korea. kangsw@ewha.ac.kr
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Kang
authors.forename: Sue Goo
authors.initials: SG
authors.lastname: Rhee
authors.forename: Tong-Shin
authors.initials: TS
authors.lastname: Chang
authors.forename: Woojin
authors.initials: W
authors.lastname: Jeong
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Choi
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D018384:Oxidative Stress / Q000502:physiology*; D010544:Peroxidases / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D054464:Peroxiredoxins; D017382:Reactive Oxygen Species / Q000378:metabolism*; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species; D010544:Peroxidases; C504194:2-cys peroxiredoxin, human; D054464:Peroxiredoxins; D017479:Receptors, Platelet-Derived Growth Factor