Mechanisms of therapy-related carcinogenesis.
Therapy-related cancers, defined as second primary cancers that arise as a consequence of chemotherapy and/or radiotherapy, are unusual in that they have a well-defined aetiology. Knowledge of the specific nature of the initiating exposure and exactly when it occurred has made it easier to identify crucial genetic events and to model these in vitro and in vivo. As such, the study of therapy-related cancers has led to the elucidation of discrete mechanisms of carcinogenesis, including DNA double-strand-break-induced gene translocation and genomic instability conferred by loss of DNA repair. Unsurprisingly, some of these mechanisms seem to operate in the development of sporadic cancers.
Allan
James M
JM
Epidemiology and Genetics Unit, Department of Biology, University of York, Heslington, York, YO10 5YW, UK. Jim.Allan@egu.york.ac.uk
Travis
Lois B
LB
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016923:Cell Death; D004249:DNA Damage; D004260:DNA Repair; D042822:Genomic Instability; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D012306:Risk; D059003:Topoisomerase Inhibitors
D000970:Antineoplastic Agents; D059003:Topoisomerase Inhibitors