title: Hepatic outflow obstruction created by balloon occlusion of the hepatic vein: induced hepatic hemodynamic changes and the therapeutic applications of hepatic venous occlusion with a balloon catheter in interventional radiology.
abstract: Hepatic outflow obstruction created by balloon occlusion of the hepatic vein induces characteristic angiographic findings in the occluded area: prolonged enhancement on hepatogram followed by reversed portal opacification on the hepatic arteriogram and perfusion defect on the arterial portogram. The following induced hepatic hemodynamic changes are suggested: hepatic arterial flow increases, and the portal vein acts as a draining vein with slow reversed flow. These unique hemodynamic changes enhance the effect of hepatic interventional therapies. In transcatheter arterial infusion, increasing hepatic arterial flow and absence of portal inflow can bring about a high concentration of drugs, the presence of which is greatly protracted due to outflow blockage. In transcatheter arterial chemoembolization, reversed portal flow can allow portal embolization in addition to arterial embolization. In microwave coagulation therapy and radiofrequency ablation therapy, decreasing portal flow can cause larger areas of coagulation. Further, the technique of hepatic venous occlusion has potential therapeutic applications.
authors.affiliation: Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. takaoh@tc4.so-net.ne.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Hiraki
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanazawa
mesh_terms: D017115:Catheter Ablation / Q000379:methods; D002404:Catheterization / Q000379:methods*; D004621:Embolization, Therapeutic / Q000379:methods; D006503:Hepatic Veins / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000473:pathology / Q000601:surgery; D008107:Liver Diseases / Q000628:therapy*; D015642:Radiology, Interventional / Q000379:methods*