title: Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide.
abstract: The kinetics decomposition of 2-chloroethylnitrososulfamides (CENS) was studied in aqueous buffered solutions with pH ranging from 0 to 14. The study was monitored by RP-LC-MS and conventional UV spectrophotometry. The reaction proceeded via a pseudo-first-order kinetic with significant correlation coefficient. The major decomposition products from CENS after incubation in phosphate buffer were isolated and identified by NMR and mass spectrometry. The results indicate that the mechanism pathway involves a denitrosation of the CENS and competitive hydrolysis with nucleophilic attack on the sulfur atom and formation of sulfamate compounds.
authors.affiliation: Laboratoire de Chimie Appliquée, Université de Guelma, BP 401, 24000 Guelma, Algeria.
authors.forename: Achour
authors.initials: A
authors.lastname: Seridi
authors.forename: Mekki
authors.initials: M
authors.lastname: Kadri
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdaoui
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Winum
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montero
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D018906:Antineoplastic Agents, Alkylating; D009603:Nitroso Compounds; D013449:Sulfonamides; D014867:Water