Synthesis of the C(43)-C(67) fragment of amphidinol 3.
[reaction: see text] A synthesis of the C(43)-C(67) fragment of amphidinol 3 (AM3) has been accomplished by a route that features the use of a double allylboration reaction for synthesis of 1,5-diol 4b, which serves as a precursor to dihydropyran 11.
Hicks
Jacqueline D
JD
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Flamme
Eric M
EM
Roush
William R
WR
D000438:Alcohols / Q000138:chemical synthesis*; D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D004141:Dinoflagellida / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D000095722:Amphidinols
D000438:Alcohols; D000475:Alkenes; D001896:Boron Compounds; D011714:Pyrans; C438973:amphidinol 3; D000095722:Amphidinols