title: Right basal ganglion hypoperfusion in obsessive compulsive disorder patients demonstrated by Tc-99m-HMPAO brain perfusion spect: a controlled study.
abstract: The aim of this study is to demonstrate the regional cerebral blood flows (rCBF) of obsessive-compulsive disorder (OCD) patients compared to controls by using Tc-99m-HMPAO SPECT. Sixteen OCD and seven control subjects were admitted into the study. Yale-Brown Obsessive Compulsive Rating Scale (Y-BOCS), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Rating Scale (HARS) were applied to the patients. The rCBF was found to be decreased in right basal ganglion in OCD patients. The right basal ganglion rCBF was negatively correlated with Y-BOCS total and compulsion scores. The left thalamus rCBF was negatively correlated with Y-BOCS obsession score. Right and left cingulate rCBF were negatively correlated with HDRS score. The results indicating hypoperfusion in right basal ganglion in OCD patients support previous findings about dysfunction of frontal-subcortical circuits in this disorder.
authors.affiliation: Department of Psychiatry, Marmara University Medical School, Istanbul, Turkey. voltop67@hotmail.com
authors.forename: Volkan
authors.initials: V
authors.lastname: Topçuoglu
authors.forename: Bahar
authors.initials: B
authors.lastname: Cömert
authors.forename: Aytül
authors.initials: A
authors.lastname: Karabekiroglu
authors.forename: Fuat
authors.initials: F
authors.lastname: Dede
authors.forename: Tanju Yusuf
authors.initials: TY
authors.lastname: Erdil
authors.forename: Halil Turgut
authors.initials: HT
authors.lastname: Turoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D001479:Basal Ganglia / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime