title: Recent advances in aryl C-glycoside synthesis.
abstract: Aryl C-glycosides are stable analogs of the corresponding O-glycosides. Because of their favorable pharmacological profiles attributed primarily to the C-glycosyl moiety, aryl C-glycosides have gained increasing popularity as drug candidates. In this review we focus on the synthesis of aryl C-glycosides including puerarin and kendomycin. This review is organized based on the type of chemistry used in the assembly of the C-glycosides with the following sub-sections: electrophilic reaction, cross-coupling reaction, free radical reaction, cyclization, intramolecular O-C rearrangement, umpolung, and miscellaneous reactions.
authors.affiliation: Bioorganic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. dlee@mclean.harvard.edu
authors.forename: David Y W
authors.initials: DY
authors.lastname: Lee
authors.forename: Minsheng
authors.initials: M
authors.lastname: He
mesh_terms: D002244:Carbon / Q000737:chemistry; D003500:Cyclization; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D008670:Metals / Q000737:chemistry
chemical_list: D006027:Glycosides; D008670:Metals; D002244:Carbon