The 2.3 genotype of ESRRA23 of the ERR alpha gene is associated with a higher BMI than the 2.2 genotype.
ERR alpha (NR3B1) is an orphan nuclear receptor believed to be involved in energy metabolism and obesity. A 23-base pair sequence in the 5'-flanking region of the ERR alpha gene, referred to as ESRRA23, is polymorphic in human chromosomes. Here, we investigated the influence of the ESRRA23 polymorphism on obesity in 703 Japanese individuals by analyzing indices of obesity and related lifestyle factors. The frequency of genotypes was similar to that reported in whites. The 2.3-genotype was associated with a significantly higher BMI than was the 2.2-genotype. An increased number of ESRRA23 repeats may be a genetic factor in human obesity.
Kamei
Yasutomi
Y
National Institute of Health and Nutrition, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8636, Japan.
Lwin
Htay
H
Saito
Kyoko
K
Yokoyama
Tetsuji
T
Yoshiike
Nobuo
N
Ezaki
Osamu
O
Tanaka
Heizo
H
D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D008019:Life Style; D008297:Male; D011110:Polymorphism, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*; D000097983:ERRalpha Estrogen-Related Receptor
D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor