Comparison of conscious sedation for oocyte retrieval between low-anxiety and high-anxiety patients.
OBJECTIVE
To investigate the correlation among the level of anxiety, the intravenous propofol requirement for conscious sedation, and recovery profile in in vitro fertilization patients.


METHODS
Prospective, randomized, double-blinded study.


METHODS
Operating room of tertiary-care university hospital.


METHODS
One hundred fifty consecutive women scheduled for oocyte retrieval under conscious sedation.


METHODS
Anxiety scores were separately measured by an anesthesiologist who was not involved in sedation. The patients were divided into 2 groups, high-anxiety and low-anxiety, as determined by using the median of anxiety VAS scoring for assessment of preoperative anxiety (4.0 cm). The subjects were collected, 76 in high-anxiety group and 74 in low-anxiety group.


METHODS
An infusion of propofol with a preset target concentration of 2.5 microg/mL(-1) was started until the patient had reached and maintained a sedation level of 3 on a 5-point sedation scale. Hemodynamic variables were recorded by using standard monitors. The scorings of sedation, operability, and satisfaction were assessed by one of the investigator-anesthesiologists. Data of induction quality and concentration of propofol were obtained from Target-Controlled Infusion system that runs on a microcomputer connected to an infusion pump (Becton-Dickinson infusion system, Le Grande chemin, France). Recovery data were measured in the recovery room.


RESULTS
The high-anxiety group required more for the induction of sedation and a larger amount of total dosage of propofol for sedation, as compared with the low-anxiety group. The concentrations of propofol on the Target-Controlled Infusion at sedation level 3 of the high-anxiety group were significantly higher than those of the low-anxiety group. Context-sensitive half time of high-anxiety group was also longer than that of the low-anxiety group. The postoperative pain score of the high-anxiety group was higher than that of the low-anxiety group. Increased preoperative anxiety was significantly correlated with postoperative wound pain (r = 0.240, P = 0.009) and previously experienced pain on same procedure (r = 0.252, P = 0.031), but not with pain on propofol injection (r = -0.05, P = 0.58).


CONCLUSIONS
The high-anxiety group needs more sedative requirement of propofol for conscious sedation than the low-anxiety group. Thus, we suggest that propofol dose for such sedation must take into account the individual patient's anxiety level when propofol is administered by an anesthesiologist for oocyte retrieval.
Hong
Jeong-Yeon
JY
Department of Anesthesiology, Samsung Cheil Hospital and Sungkyunkwan University School of Medicine, Seoul 100-380, South Korea. jisaac@hanmail.net
Jee
Young Suck
YS
Luthardt
Frederick W
FW
D000328:Adult; D001007:Anxiety / Q000523:psychology*; D015331:Cohort Studies; D016292:Procedural Sedation / Q000523:psychology*; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D018587:Oocyte Donation / Q000523:psychology*; D010146:Pain / Q000453:epidemiology; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D015742:Propofol; D011446:Prospective Studies; D011594:Psychometrics
D006993:Hypnotics and Sedatives; D015742:Propofol