Serological markers (anti-Saccharomyces cerevisiae mannan antibodies and antineutrophil cytoplasmic antibodies) in inflammatory bowel disease: diagnostic utility and phenotypic correlation.
We have evaluated the utility of antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies for distinguishing Crohn's disease from ulcerative colitis and other diarrheal illnesses by evaluating sera from 396 patients. Sensitivity, specificity, and phenotypic correlations were investigated. The implications of our findings for implementing these tests in routine clinical testing are discussed.
Buckland
M S
MS
Department of Clinical Immunology, 1st Floor, 51-53 Barts Close, W. Smithfield, St. Bartholomew's, London EC1A 7BE, United Kingdom. matthew.buckland@bartsandthelondon.nhs.uk
Mylonaki
M
M
Rampton
D
D
Longhurst
H J
HJ
D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000276:immunology; D003424:Crohn Disease / Q000175:diagnosis / Q000276:immunology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000145:classification / Q000209:etiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000145:classification / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D008351:Mannans / Q000276:immunology*; D011237:Predictive Value of Tests; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D012680:Sensitivity and Specificity
D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D008351:Mannans