Close encounters between active genes in the nucleus.
A recent paper demonstrates that coregulated genes on different chromosomes show surprisingly high frequencies of colocalization within the nucleus; this complements similar results found previously for genes localized tens of megabases apart on a single chromosome. Colocalization could be related to the earlier observation of active genes associating with foci where RNA polymerase II is concentrated.
Chuang
Chien-Hui
CH
Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Belmont
Andrew S
AS
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D045584:Chromosome Positioning; D002875:Chromosomes / Q000235:genetics*; D005786:Gene Expression Regulation; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D051379:Mice; D008957:Models, Genetic; D014158:Transcription, Genetic / Q000502:physiology