title: Cardiac developmental biology: from flies to humans.
abstract: The heart is the first organ to form during embryogenesis, and heart formation is essential for subsequent embryonic development. Since the identification of a cardiac-restricted transcription factor Csx/Nkx-2.5 in the early 1990s, extensive studies on cardiac development have been done in various species ranging from flies to humans. Molecular dissection of regulatory pathways that control multiple steps of cardiogenesis will not only advance our understanding of cardiac development and congenital heart diseases, but will also provide an important clue to novel therapeutic strategies for heart diseases.
authors.affiliation: Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. komuro-tky@umin.ac.jp.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Shiojima
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000818:Animals; D015509:Developmental Biology; D004175:Diptera / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D014157:Transcription Factors / Q000235:genetics
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors