title: Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4).
abstract: Chemokines are crucial immune mediators in many physiological and pathophysiological conditions. Chemokines have been hypothesized to be involved in macrophage infiltration into adipose tissue in obesity and might therefore play an important role in the development of obesity-related disorders like type 2 diabetes. Out of 1,653 individuals aged 55-74 years participating in a population-based survey in southern Germany (the Kooperative Gesundheitsforschung in der Region Augsburg [KORA] [Cooperative Health Research in the Region of Augsburg] Survey S4, 1999-2001), 236 individuals with type 2 diabetes, 242 subjects with impaired glucose tolerance (IGT), and 244 normoglycemic control subjects were studied for circulating concentrations of interleukin (IL)-8; RANTES (regulated on activation, normal T-cell expressed, and secreted); interferon-gamma-inducible protein-10 (IP-10), and eotaxin. Systemic concentrations of RANTES were higher in individuals with IGT or type 2 diabetes than in control subjects, whereas IL-8 levels were elevated in type 2 diabetic patients only (P < 0.001 for all comparisons). IP-10 and eotaxin were not significantly associated with IGT or type 2 diabetes. Adjustment for age, sex, BMI, hypertension, LDL cholesterol, HDL cholesterol, uric acid, C-reactive protein, and IL-6 did not alter these findings. Our findings indicate that RANTES and IL-8 may be involved in the development of type 2 diabetes independent of metabolic syndrome-related risk factors and of each other. There is no general upregulation of chemokine production in type 2 diabetes, but rather an association of the disease with specific members of the chemokine family.
authors.affiliation: German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich-Heine University, Auf'm Hennekamp 65, 40225 Düsseldorf, Germany. christian.herder@ddz.uni-duesseldorf.de
authors.forename: Christian
authors.initials: C
authors.lastname: Herder
authors.forename: Burkhard
authors.initials: B
authors.lastname: Haastert
authors.forename: Sylvia
authors.initials: S
authors.lastname: Müller-Scholze
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Koenig
authors.forename: Barbara
authors.initials: B
authors.lastname: Thorand
authors.forename: Rolf
authors.initials: R
authors.lastname: Holle
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Werner A
authors.initials: WA
authors.lastname: Scherbaum
authors.forename: Stephan
authors.initials: S
authors.lastname: Martin
authors.forename: Hubert
authors.initials: H
authors.lastname: Kolb
mesh_terms: D000368:Aged; D001794:Blood Pressure; D054413:Chemokine CCL11; D018946:Chemokine CCL5 / Q000097:blood; D054357:Chemokine CXCL10; D019742:Chemokines, CC / Q000097:blood; D019743:Chemokines, CXC / Q000097:blood; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000276:immunology; D005260:Female; D005858:Germany; D018149:Glucose Intolerance / Q000097:blood* / Q000276:immunology; D006306:Health Surveys; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: C515456:CCL11 protein, human; C114753:CXCL10 protein, human; D054413:Chemokine CCL11; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D019742:Chemokines, CC; D019743:Chemokines, CXC; D016207:Cytokines; D007375:Interleukin-1; D016209:Interleukin-8