[Effect of sodium-rich diet and captopril on the functional state of kidney in rats with experimental hyperthyreosis].
The administration of thyroxin (10 microg/100 g body weight, 7 days) in rats leads to an increase in the renal excretion of proteins and nitrates. Under the conditions of hypo- and normosodium diet, thyroxin decreased the rate of glomerular filtration. Hypersodium diet and captopril increased the rate of glomerular filtration in rats with experimental hyperthyreosis. The maximum level of renal excretion in hyperthyreoidal rats was observed on the background of sodium-rich diet.
Dolomatov
S I
SI
Gozhenko
A I
AI
Larina
I M
IM
Buravkova
L B
LB
Dolomatova
E A
EA
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D004039:Diet, Sodium-Restricted; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D013974:Thyroxine / Q000633:toxicity; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000959:Antihypertensive Agents; D002216:Captopril; D012964:Sodium; D013974:Thyroxine