title: HPV and p53 expression in dysplastic lesions and squamous carcinomas of the oral mucosa.
abstract: We studied 18 premalignant and malignant lesions of the oral mucosa, 3 dysplasias, and 15 oral squamous carcinomas with varied localizations: lips, palate, and tongue. Immunoassays for HPV were positive in 42.8% of the squamous carcinomas, without correlation with the pattern or the degree of differentiation of the lesions. P53 immuno-expression was positive in 2 of the 3 studied cases of dysplasia (66.6%) and in 13 from the 15 cases of squamous carcinomas (86.6%). The p53 immuno-positivity in both lesional categories, with a higher rate in carcinomas, indicates the fact that the p53 gene mutations can appear precocious in the oral carcinogenesis, but can not be used as malign potential prediction factor.
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Craiova. csimionescu2004@lyahoo.com
authors.forename: Cristiana
authors.initials: C
authors.lastname: Simionescu
authors.forename: Cl
authors.initials: C
authors.lastname: Mărgăritescu
authors.forename: Claudia Valentina
authors.initials: CV
authors.lastname: Georgescu
authors.forename: M
authors.initials: M
authors.lastname: Surpăţeanu
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D009061:Mouth Mucosa / Q000473:pathology* / Q000821:virology; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D016159:Tumor Suppressor Protein p53