Prostatic extramedullary leukemia as a first site of relapse of acute nonlymphocytic leukemia.
Extramedullary leukemia (EML) is an uncommon clinical diagnosis in patients with acute nonlymphocytic leukemia (ANLL). Prostatic EML as a first site of ANLL relapse is even more rare. To our knowledge, only three cases have been reported. We describe an additional case of prostatic EML as a site of ANLL relapse. An asymptomatic male in ANLL remission was found to have a normal prostate-specific antigen (PSA) and a myeloid leukemic infiltrate in a newly diagnosed prostate nodule. Staging was negative for ANLL relapse. Local prostate radiation resolved the nodule, and the post-treatment needle biopsies were negative. He subsequently developed clinical relapse in bone marrow, blood, and small bowel and received salvage chemotherapy with mitoxantrone and etoposide.
Anderson
Gregory A
GA
Department of Urology, Marshfield Clinic, Marshfield, WI, USA. anderson.gregory@marshfieldclinic.org
Braaten
Kristina
K
D000368:Aged; D001706:Biopsy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000556:secondary*