title: Low-barrier hydrogen bond between phosphate and the amide group in phosphopeptide.
abstract: As the conversion between the monoionic (1) and diionic (2) form of the phosphate occurs, the phosphorylated peptides or proteins can not only cause the formation of a hydrogen bond between the phosphate group and the amide group but also change the strength of the hydrogen bond to form low-barrier hydrogen bonds (LBHBs). This reversible protonation of the phosphate group, which changes both the electrostatic properties of the phosphate group and the strength of the hydrogen bond, provides a possible mechanism in regulating protein function.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Jin-Tang
authors.initials: JT
authors.lastname: Du
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Guo-Shi
authors.initials: GS
authors.lastname: Wu
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Zhao
authors.forename: Kenji
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nemoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakanishi
mesh_terms: D000577:Amides / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry*; D010748:Phosphopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D016875:tau Proteins / Q000737:chemistry
chemical_list: D000577:Amides; D010710:Phosphates; D010748:Phosphopeptides; D016875:tau Proteins