title: [Clinical aspects and pathogenesis of UV-induced pigmentary disorders].
abstract: Solar and ultraviolet (UV) radiation, respectively, are the strongest stimuli for the induction of pigmentation in human skin. UV radiation induces pigmentation by exerting direct and indirect effects on melanocytes. Melanogenesis is a very complex process whose molecular mechanisms are not yet completely understood. Acute UV exposure induces the non-protective immediate pigment darkening as well as delayed tanning which exerts photoprotective effects. Chronic UV exposure causes permanent pigmentary changes by inducing solar lentigines and pigmented actinic keratoses as well hypopigmentated areas. Artificial UV irradiation (UVA, PUVA) can also induce pigmentary disorders, including lentigines. Since the therapeutic options for UV-induced pigmentary changes are limited consequent protection as a prophylactic measure is recommended.
authors.affiliation: Hautklinik, Hôpital L'Archet 2, Nizza, Frankreich.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Ortonne
authors.forename: Thomas
authors.initials: T
authors.lastname: Schwarz
mesh_terms: D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D010859:Pigmentation Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D013473:Sunscreening Agents / Q000627:therapeutic use; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D013473:Sunscreening Agents