Neuroprotective properties of afobazol in vitro.
The effects of a novel selective anxiolytic afobazol on survival of HT-22 neurons were studied in the model of oxidative stress and glutamate toxicity. In both models, the neuroprotective effect of afobazol was established.
Zenina
T A
TA
Department of Pharmacological Genetics, V. V. Zakusov State Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Gavrish
I V
IV
Melkumyan
D S
DS
Seredenina
T S
TS
Seredenin
S B
SB
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival; D018698:Glutamic Acid / Q000737:chemistry / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D009025:Morpholines / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D018696:Neuroprotective Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D018698:Glutamic Acid; D006861:Hydrogen Peroxide; C022616:thiazolyl blue