The anti-thrombotic activity of surfactins.
Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents.
Lim
Jong-hwan
JH
College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
Park
Byung-kwon
BK
Kim
Myoung-seok
MS
Hwang
Mi-Hyun
MH
Rhee
Man-Hee
MH
Park
Seung-Chun
SC
Yun
Hyo-in
HI
D001412:Bacillus subtilis / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology
D005343:Fibrinolytic Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors; C009365:surfactin peptide