title: Prevalence of high-grade CIN following mild dyskaryotic smears in different age groups.
abstract: OBJECTIVE
  The new guidelines of the British Society of Colposcopy and Cervical Pathology suggest that women should be offered colposcopy after only one mildly dyskaryotic smear. This is expected to generate increased workload for the colposcopy clinics, at least in the short term. The main objective of this study was to estimate the incidence of high-grade cervical intraepithelial neoplasia (CIN) in women with mildly dyskaryotic smears and investigate whether there is any variation in different age groups. The rationale was to determine whether we could reduce the burden on colposcopy services by prioritizing the mild dyskaryotic referrals by age, as we hypothesized that high-grade CIN is less frequent in younger women.
  
  
  METHODS
  The study sample included all women who were referred for colposcopy with a cervical smear suggesting mild dyskaryosis (with or without koilocytosis) from April 2000 to March 2003.
  
  
  RESULTS
  We studied 510 women. They were divided into three age groups (<20, 20-25 and >25 years). The overall prevalence of high-grade CIN (CIN II and III) was 28.7%. The positive predictive value of a mildly dyskaryotic smear for high-grade CIN was similar in all groups.
  
  
  CONCLUSIONS
  Our results show that we are not in a position to prioritize our referrals by age group and reduce the initial pressure for colposcopies. We are also concerned that with the implementation of the new guidelines, a significant number of women <25 years will be carrying high-grade CIN for more than 5 years before they are first screened.
authors.affiliation: Department of Gynaecological Oncology, Royal Surrey County Hospital, Guildford, Surrey, UK. tgiuk@yahoo.co.uk
authors.forename: T
authors.initials: T
authors.lastname: Giannopoulos
authors.forename: S
authors.initials: S
authors.lastname: Butler-Manuel
authors.forename: A
authors.initials: A
authors.lastname: Tailor
authors.forename: E
authors.initials: E
authors.lastname: Demetriou
authors.forename: L
authors.initials: L
authors.lastname: Daborn
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003127:Colposcopy / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D015995:Prevalence; D012017:Referral and Consultation; D006113:United Kingdom / Q000453:epidemiology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D014626:Vaginal Smears