title: Strain improvement studies on production of cephalosporin C from Acremonium chrysogenum ATCC 48272.
abstract: Strain development for antibiotic production has been an essential prerequistie for efficient production process. Studies were carried out to produce high antibiotic yield strain by using UV and N-methyl-N1-nitro-nitrosoguanidine (NTG) as mutagens. A superior mutant (PNTG-22) with a productivity of 2.4 time (810-1995 microg/ml higher than, the parent strain was produced.
authors.affiliation: Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh 530 003, India.
authors.forename: P
authors.initials: P
authors.lastname: Ellaiah
authors.forename: J Prem
authors.initials: JP
authors.lastname: Kumar
authors.forename: V
authors.initials: V
authors.lastname: Saisha
authors.forename: J J
authors.initials: JJ
authors.lastname: Sumitra
authors.forename: P
authors.initials: P
authors.lastname: Vaishali
mesh_terms: D000164:Acremonium / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D002511:Cephalosporins / Q000096:biosynthesis*; D009154:Mutation; D013056:Spectrophotometry, Ultraviolet; D013172:Spores, Fungal / Q000737:chemistry
chemical_list: D002511:Cephalosporins; C025163:cephalosporin C