Surprisingly efficient catalytic Cr-mediated coupling reactions.
[reaction: see text] With use of 1 mol % of Cr catalyst 5, surprisingly efficient Cr-mediated couplings of aldehydes with various types of nucleophiles have been realized. The catalyst set of Cr catalyst 5 and Ni catalyst 4 is used for alkenylation, alkynylation, and arylation, whereas the catalyst set of Cr catalyst 5 and CoPc (cobalt phthalocyanine) is used for 2-haloallylation, alkylation, and propargylation. Only the Cr catalyst 5 is required for allylation. The reaction rates in DME and THF have been found significantly faster than that in MeCN.
Namba
Kosuke
K
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Wang
Jiashi
J
Cui
Sheng
S
Kishi
Yoshito
Y
D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D002857:Chromium / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry
D000447:Aldehydes; D002857:Chromium; D009532:Nickel