title: [Possibility of the use of serological method for the determination of immunoglobuline A antibody against early antigene of Epstein-Barr virus as a marker in the diagnosis of nasopharyngeal tumors].
abstract: OBJECTIVE
  According to the data from immunological, biological and molecular researches, there is a close association between the undifferentiated carcinoma of nasopharyngeal type (UCNT) and Epstein-Barr virus (EBV). To use IgA EA antibody as a serological marker in our patients with nasopharyngeal carcinoma from a clinical viewpoint.
  
  
  METHODS
  91 patients were followed in the period from 1989-1998. In 11 of the patients the antibody titre serum for the early antigen of EBV virus were determinated before the treatement, and in 24 of the patients 3 years after the treatement. There were three control groups of patients: 20 voluntary blood donors, 26 patients with squamocellular laryngeal carcinoma, and 10 patients with squamocellular nasopharyngeal carcinoma.
  
  
  RESULTS
  In the group of 11 patients with UCNT before the treatment, the value of anti-EA IgA titre was 31.09, and in the patients after the treatement anti-EA IgA antiody titre was 14.56. In the control groups of patients the results were: in the blood donors 5.00; in the group with the diagnosis of squamocellular laryngeal carcinoma, the titre was 5.00; in the patients with squamocellular nosopharyngeal carcinoma, the titre anti-EA IgA was 5.36.
  
  
  CONCLUSIONS
  These results were statisticly highly significant (p < 0.01). Our research clearly showed that anti-EA IgA EBV marker could be useful in diagnosing, differential diagnosing and prognosing as well.
authors.affiliation: Klinika centar Srbiji, Institut za otorinolaringologiju i masksilofacijalnu hirurgiju, Beograd, Srbija i Crna Gora. lanaaki@eunet.yu
authors.forename: Svetlana
authors.initials: S
authors.lastname: Stosić-Divjak
authors.forename: Vojko
authors.initials: V
authors.lastname: Dukić
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Petrović
authors.forename: Vladimir
authors.initials: V
authors.lastname: Nesić
authors.forename: Alek
authors.initials: A
authors.lastname: Racić
authors.forename: Zoran
authors.initials: Z
authors.lastname: Tatić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kanjuh
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D003937:Diagnosis, Differential; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000628:therapy / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D014408:Biomarkers, Tumor; D007070:Immunoglobulin A