Multiple roles of cyclooxygenase-2 in endometrial cancer.
Cyclooxygenase-2 (COX-2) plays a critical role not only in maintenance of the endometrium during the menstrual cycle, but also in the progression of endometrial cancer. The role of COX-2 in tumor growth and development is complex and multifaceted. This review presents evidence for the expression of COX-2 being linked to angiogenesis, tumor cell apoptosis, tumor cell growth, metastasis and local immunosuppression in cancer progression. It also outlines the clinicopathological and prognostic significance of COX-2 in endometrial cancer.
Ohno
Satoshi
S
Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan. satoshio@cit.med.osaka-u.ac.jp
Ohno
Yumiko
Y
Suzuki
Nobutaka
N
Inagawa
Hiroyuki
H
Kohchi
Chie
C
Soma
Gen-Ichiro
G
Inoue
Masaki
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans
D051546:Cyclooxygenase 2