title: Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients.
abstract: Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, University of Washington, Seattle, USA. wmuller@u.washington.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Muller
authors.forename: Myron J
authors.initials: MJ
authors.lastname: Levin
authors.forename: Young Kyoo
authors.initials: YK
authors.lastname: Shin
authors.forename: Christine
authors.initials: C
authors.lastname: Robinson
authors.forename: Ralph
authors.initials: R
authors.lastname: Quinones
authors.forename: Janet
authors.initials: J
authors.lastname: Malcolm
authors.forename: Elaine
authors.initials: E
authors.lastname: Hild
authors.forename: Dexiang
authors.initials: D
authors.lastname: Gao
authors.forename: Roger
authors.initials: R
authors.lastname: Giller
mesh_terms: D000256:Adenoviridae / Q000187:drug effects; D000258:Adenovirus Infections, Human / Q000188:drug therapy* / Q000209:etiology*; D000293:Adolescent; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D063065:Organophosphonates / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir