Synthesis and anti-HCMV activity of novel 5'-norcarboacyclic nucleosides.
A very simple route for synthesizing a novel carboacyclic version of 5 cent-noraristeromycin is described. Condensation of the mesylates 9 and 23 with the natural nucleosidic bases (A, U, T, C) under standard nucleophilic substitution (K(2)CO(3), 18-Crown-6, DMF) and deblocking conditions, afforded the target nucleosides 14, 15, 16, 17, 28, 29, 30, and 31. In addition, these compounds were evaluated for their antiviral properties against various viruses.
Kim
Aihong
A
College of Pharmacy, Chosun University, Kwangju, Republic of Korea.
Hong
Joon Hee
JH
D000998:Antiviral Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects*; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D009705:Nucleosides