Eosinophilic pleurisy induced by dantrolene.
A 70-year-old male developed eosinophilic pleurisy fifteen years after dantrolene sodium had been started for his spastic paraplegia due to spinocerebellar degeneration. Drug lymphocyte stimulation test (DLST) for dantrolene was positive. After discontinuance of dantrolene, pleural effusion gradually decreased and inflammatory reaction improved. During two-year observation, we have found no relapse of pleurisy without special medication. We present this case and compare this case with other 10 reported cases.
Urano
Tetsuya
T
Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara City, Kanagawa 259-1193, Japan. urantets@is.icc.u-tokai.ac.jp
Nishiumi
Mai
M
Tajiri
Sakurako
S
Ishii
Hiroshi
H
Tanigaki
Toshimori
T
Kobayashi
Kenji
K
Kita
Fumiko
F
Tokuoka
Kentaro
K
Nagayama
Masao
M
Eguchi
Kenji
K
D000368:Aged; D003620:Dantrolene / Q000009:adverse effects* / Q000627:therapeutic use; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects* / Q000627:therapeutic use; D010264:Paraplegia / Q000188:drug therapy / Q000209:etiology; D010998:Pleurisy / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D013902:Radiography, Thoracic; D013132:Spinocerebellar Degenerations / Q000150:complications / Q000188:drug therapy
D009125:Muscle Relaxants, Central; D003620:Dantrolene