Evaluation of oxazaborolidine activity on Streptococcus mutans biofilm formation.
Dental diseases are among the most prevalent afflictions of humankind. These diseases are associated with the formation of biofilms harbouring pathogenic bacteria. Eight different derivatives of oxazaborolidines were synthesised and evaluated for their affect on Streptococcus mutans adhesion and biofilm formation. Structure-activity relationship was observed. The B-butyl moiety of the oxazaborolidines contributed an anti-adhesion effect for all derivatives, whilst its effect diminished when the boron atom was incorporated in a fused heterocyclic ring. The B-phenyl group induced bacterial adhesion in all tested compounds Oxazaborolidines may serve as novel agents for affecting oral biofilm formation. Moreover, the ability to alter the oxazaborolidine molecule and thus affect biofilms offers an excellent opportunity to study biofilm formation.
Jabbour
Adel
A
Institute of Dental Sciences, Faculty of Dentistry, Hebrew University-Hadassah, P.O.B 12272, Jerusalem, 91120 Israel.
Srebnik
Morris
M
Zaks
Batia
B
Dembitsky
Valerie
V
Steinberg
Doron
D
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013295:Streptococcus mutans / Q000187:drug effects* / Q000502:physiology
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D001896:Boron Compounds