title: Costs and quality of life associated with osteoporosis-related fractures in Sweden.
abstract: This prospective observational data collection study assessed the cost and quality of life related to hip, vertebral and wrist fracture 1 year after the fracture, based on a patient sample consisting of 635 male and female patients surviving a year after fracture. Data regarding resource use and quality of life related to fractures was collected by questionnaires at baseline, 4 months and 12 months. Information was collected by the use of patients' records, register sources and by asking the patient. Quality of life was estimated with the EQ-5D questionnaire. Costs were estimated from a societal perspective, including direct and indirect costs. The mean fracture-related cost the year after a hip, vertebral and wrist fracture were estimated, in euros (<euro>), at <euro>14,221, <euro>12,544 and <euro>2,147, respectively [converted from Swedish krona (SEK) at an exchange rate of 9.1268 SEK/<euro>]. The mean reduction in quality of life was estimated at 0.17, 0.26 and 0.06 for hip, vertebral and wrist fracture, respectively. Based on the results, the yearly burden of osteoporosis in Sweden could be estimated at <euro>0.5 billion (SEK 4.6 billion). The patient sample for vertebral fracture was fairly small and included a high proportion of fractures leading to hospitalization, but they indicate a higher cost and loss of quality of life related to vertebral fracture than previously perceived.
authors.affiliation: Medical Management Centre, Karolinska Institutet, Stockholm, Sweden. frederik.b@healtheconomics.se
authors.forename: Fredrik
authors.initials: F
authors.lastname: Borgström
authors.forename: Niklas
authors.initials: N
authors.lastname: Zethraeus
authors.forename: Olof
authors.initials: O
authors.lastname: Johnell
authors.forename: Lars
authors.initials: L
authors.lastname: Lidgren
authors.forename: Sari
authors.initials: S
authors.lastname: Ponzer
authors.forename: Olle
authors.initials: O
authors.lastname: Svensson
authors.forename: Peter
authors.initials: P
authors.lastname: Abdon
authors.forename: Ewald
authors.initials: E
authors.lastname: Ornstein
authors.forename: Karl
authors.initials: K
authors.lastname: Lunsjö
authors.forename: Karl Göran
authors.initials: KG
authors.lastname: Thorngren
authors.forename: Ingemar
authors.initials: I
authors.lastname: Sernbo
authors.forename: Clas
authors.initials: C
authors.lastname: Rehnberg
authors.forename: Bengt
authors.initials: B
authors.lastname: Jönsson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003365:Costs and Cost Analysis; D005260:Female; D050723:Fractures, Bone / Q000191:economics* / Q000209:etiology; D006620:Hip Fractures / Q000191:economics / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000191:economics*; D011446:Prospective Studies; D011788:Quality of Life; D016103:Spinal Fractures / Q000191:economics / Q000209:etiology; D013548:Sweden; D014954:Wrist Injuries / Q000191:economics / Q000209:etiology