Control of homeostatic proliferation by regulatory T cells.
Homeostatic proliferation of T cells leads to the generation of effector/memory cells, which have the potential to cause harm to the host. The role of Tregs in the control of homeostatic proliferation is unclear. In this study we utilized mice that either harbor or lack Tregs as recipients of monoclonal or polyclonal T cells. We observed that while Tregs completely prevented cell division of T cells displaying low affinity for self ligands, they had a less marked, albeit significant, effect on cell cycle entry of T cells displaying higher affinity. The presence of Tregs resulted in a lower accumulation of T cells, enhanced apoptosis, and impaired differentiation to a cytokine-producing state. We conclude that Tregs play a major role in the control of homeostatic proliferation.
Shen
Shiqian
S
Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
Ding
Yi
Y
Tadokoro
Carlos E
CE
Olivares-Villagómez
Danyvid
D
Camps-Ramírez
Marlin
M
Curotto de Lafaille
Maria A
MA
Lafaille
Juan J
JJ
D000818:Animals; D000906:Antibodies / Q000737:chemistry; D000911:Antibodies, Monoclonal / Q000737:chemistry; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018956:CD5 Antigens / Q000096:biosynthesis; D049109:Cell Proliferation; D002469:Cell Separation; D005434:Flow Cytometry; D016654:Genes, RAG-1; D006579:Heterozygote; D018960:Hyaluronan Receptors / Q000378:metabolism; D007156:Immunologic Memory; D020287:In Situ Nick-End Labeling; D008024:Ligands; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D004676:Myelin Basic Protein / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000166:cytology*; D013997:Time Factors; D019076:Transgenes
D000906:Antibodies; D000911:Antibodies, Monoclonal; D018956:CD5 Antigens; D018960:Hyaluronan Receptors; D008024:Ligands; D004676:Myelin Basic Protein; D011948:Receptors, Antigen, T-Cell