title: Comparison of the effects of intrathecal morphine and pethidine on shivering after Caesarean delivery under combined-spinal epidural anaesthesia.
abstract: We performed a prospective, randomised, double blind study to compare the antishivering effect of morphine and pethidine when added to intrathecal hyperbaric bupivacaine during elective Caesarean delivery under combined-spinal epidural anaesthesia. Spinal anaesthesia consisted of either 8-10 mg of 0.5% bupivacaine alone (group B; n = 30) with 0.1 mg morphine (group BM0.1; n = 29), with 0.2 mg morphine (group BM0.2; n = 30), or with 10 mg pethidine (group BPeth10; n = 30). The incidences of shivering were 23.3% (7/30) in group B, 17% (5/29) in group BM0.1, 13.3% (4/30) in group BM0.2 and 3.3% (1/30) in group BPeth10 (p < 0.05). The shivering intensity for each patient was significantly higher in group B than the other groups. In conclusion, intrathecal pethidine added to hyperbaric bupivacaine reduces the incidence and intensity of shivering more than does morphine (0.1 or 0.2 mg).
authors.affiliation: Department of Anaesthesiology, Samsung Cheil Hospital, Sungkyunkwan University, Mukjeong-Dong 1-19, Jung-Gu, Seoul (100-380), South Korea. jenyhongg@hanmail.net
authors.forename: J-Y
authors.initials: JY
authors.lastname: Hong
authors.forename: I H
authors.initials: IH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical / Q000379:methods*; D000775:Anesthesia, Spinal; D000886:Anthropometry; D001831:Body Temperature / Q000187:drug effects; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008614:Meperidine / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D011247:Pregnancy; D011446:Prospective Studies; D012768:Shivering / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; D008614:Meperidine