Regulation of the p53 transcriptional activity.
In response to various stresses, p53 is rapidly activated and transcriptionally regulates a number of target genes by which p53 modulates a variety of cellular activities. The transcriptional activity of p53 is delicately regulated by a plethora of cellular factors, independently or synergistically, in multiple ways in order to achieve a specific response. This article reviewed the role of the basal transcriptional machinery, co-activators, and co-repressors involved in p53-dependent transcription, and the underlying mechanism by which the p53 transcriptional activity is regulated. We also discussed some potentially interesting questions and future directions in the field.
Liu
Gang
G
Department of Cell Biology, The University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA.
Chen
Xinbin
X
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000502:physiology; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000502:physiology; D015534:Trans-Activators; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
D009687:Nuclear Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D016159:Tumor Suppressor Protein p53