Prognostic effect of renal dysfunction after ST-segment elevation myocardial infarction with and without heart failure.
OBJECTIVE
The present study was designed to assess, 1) the independent prognostic effect of renal dysfunction on all-cause mortality in the setting of acute myocardial infarction with ST-segment elevation (STEMI), and 2) to determine if such effect varies based upon the presence of heart failure (HF) on admission.


METHODS
549 consecutive patients admitted with the diagnosis of STEMI were prospectively recruited in a teaching hospital in Spain. Serum creatinine (sCr) and glomerular filtration rate (GFR) were obtained on admission, together with other relevant information used for risk stratification. The independent effect of sCr and GFR on long-term mortality was determined by Cox regression analysis. Main outcome was all-cause mortality, with a median follow-up of 1 year.


RESULTS
In a multivariate analysis the degree of renal impairment was a strong predictor of mortality in patients without clinical evidence of HF at admission (HR=1.15; 95% CI 1.10 to 1.19 and HR=1.58; 95% CI 1.30 to 1.81) for sCr (per 0.1 mg/dl) and GFR (per decreasing 10 ml/min/1.73 m2), respectively. In the group with HF, the effect was less pronounced (HR=1.03; 95% CI 1.01 to 1.04 and HR=1.17; 95% CI 1.02 to 1.37) for sCr and GFR, respectively.


CONCLUSIONS
In the setting of STEMI, renal dysfunction estimates showed a differential prognostic effect depending on HF status, with a greater impact seen in patients without clinical evidence of HF.
Bertomeu-Gonzalez
Vicente
V
Cardiology Department, Valencia Clinic University Hospital, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain. vbertog@secardiologia.es
Núñez
Julio
J
Núñez
Eduardo
E
Fácila
Lorenzo
L
Sanchis
Juan
J
Bodí
Vicent
V
Pellicer
Mauricio
M
Bosch
María J
MJ
Martínez
Angel
A
Chorro
Francisco J
FJ
Llàcer
Angel
A
D000368:Aged; D015897:Comorbidity; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D013318:Stroke Volume; D016019:Survival Analysis
D003404:Creatinine