Visceral adiposity and apolipoprotein C-III in apolipoprotein B-containing lipoproteins are independent predictors in determining atherogenic lipid profiles.
OBJECTIVE
Little is known about how visceral adiposity and apolipoprotein CIII in apoB-containing lipoproteins influence atherogenic lipids profiles. The purpose of this study was to determine the relationships of visceral adiposity and apoC-III in apoB-containing lipoproteins (LpB:C-III) with lipoprotein lipids in circulating plasma.


METHODS
A subgroup of 46 men (n = 20, aged 29.1-33.4 years) and women (n = 26, aged 29.1-33.8 years) were recruited from an ongoing population study at our institution. Anthropometric variables including weight, height, and waist circumference were measured using standard procedures, and body mass index was calculated (kg/m(2)). Visceral adipose tissue (VAT) was measured with magnetic resonance imaging. Plasma apolipoproteins, lipids, glucose, and insulin were measured after an overnight fasting.


RESULTS
The men had a significantly higher waist circumference, glucose, and TC/HDL-C ratio, while the women had a significantly higher HDL-C and apoA-I. In particular, this is the first study to report that VAT and LpB:C-III were independent predictors in determining plasma triglyceride concentrations.


CONCLUSIONS
The relations of plasma triglyceride concentration with VAT and LpB:C-III suggest that information on VAT and apoC-III in apoB-containing lipoproteins may provide additional information on the atherogenic lipid profiles.
Han
Taekyong
T
School of Sports Science, Sungkyunkwan University, Kyonggi-do, South Korea.
Woo
Sang-Koo
SK
Shin
Seonae
S
Kang
Hyun-Sik
HS
D000328:Adult; D053305:Apolipoprotein C-III; D001055:Apolipoproteins B / Q000378:metabolism*; D001056:Apolipoproteins C / Q000378:metabolism*; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D001786:Blood Glucose; D001823:Body Composition / Q000502:physiology; D001827:Body Height / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D049629:Waist-Hip Ratio
D053305:Apolipoprotein C-III; D001055:Apolipoproteins B; D001056:Apolipoproteins C; D001786:Blood Glucose; D014280:Triglycerides