Neonatal hypoglycaemic encephalopathy: diffusion-weighted imaging and proton MR spectroscopy.
We report two infants with neonatal hypoglycaemic encephalopathy who were evaluated with diffusion-weighted imaging (DWI) and proton MR spectroscopy (MRS) as well as conventional MR. As in conventional MR, DWI and proton MRS revealed a predominance of abnormalities in the parieto-occipital lobes and underlying white matter including the splenium of the corpus callosum. In the acute phase of the disease, lesions on DWI showed restricted water diffusion and on DWI the characteristic lesions seemed to be more readily discernible than on conventional MRI. In the chronic phase, DWI demonstrated increased water diffusion in the affected areas showing atrophy on conventional MRI. Proton MRS revealed an increased lactate-lipid peak and a decreased NAA peak in the involved areas. DWI and proton MRS findings appear helpful in evaluating the extent and the presence of neuronal damage early in the course of neonatal hypoglycaemic encephalopathy.
Kim
So Yeon
SY
Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-2 dong, Songpa-gu, Seoul, Republic of Korea.
Goo
Hyun Woo
HW
Lim
Keun Ho
KH
Kim
Sang Tae
ST
Kim
Ki Soo
KS
D001928:Brain Diseases, Metabolic / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000150:complications* / Q000503:physiopathology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D047929:Term Birth
D011522:Protons