Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth.
Alpha2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the alpha2 integrin gene is associated with high/low alpha2 integrin expression. The aim of this study was to test the hypothesis that expression of alpha2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the controls (odds ratio, 3.61; 95% confidence interval, 2.14 - 6.10; P < 0.05). The present findings suggest that the alpha2 +807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.
Ogino
M
M
Divison of Gene Expression, Institute for Genome Research, The University of Tokushima, Kuramoto 3-18-15, Tokushima 770-8503, Japan.
Kido
J
J
Bando
M
M
Hayashi
N
N
Wada
C
C
Nagata
T
T
Nishimura
F
F
Soga
Y
Y
Takashiba
S
S
Kubota
T
T
Itagaki
M
M
Shimada
Y
Y
Tai
H
H
Yoshie
H
H
Yamazaki
N
N
Shinohara
Y
Y
Kataoka
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002121:Calcium Channel Blockers / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D003596:Cytosine; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D005787:Gene Frequency; D019214:Gingival Overgrowth / Q000139:chemically induced* / Q000235:genetics; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013941:Thymine
D002121:Calcium Channel Blockers; D039421:Integrin alpha2; D003596:Cytosine; D013941:Thymine