title: Non-fatal heroin overdose, treatment exposure and client characteristics: findings from the Australian treatment outcome study (ATOS).
abstract: The relationship between treatment exposure, drug use, psychosocial variables and non-fatal heroin overdose was examined among a cohort of 495 heroin users, re-interviewed at 12 months. The 12-month overdose rate declined from 24% to 12%, and the proportion administered naloxone declined from 15% to 7%. There were significant reductions in overdose among those who entered maintenance therapies (22% to 4%) and residential rehabilitation (33% vs. 19%) at baseline, but not among those who entered detoxification or were not entering treatment. The total number of treatment days received over the follow-up period was associated independently with a reduced risk of overdose. Each extra treatment day was associated with a 1% reduction in risk of overdose over the follow-up period. By contrast, more treatment episodes were associated with an increased risk of overdose (OR 1.62). Other independent predictors of overdose over follow-up were more extensive polydrug use (OR 1.40), and having overdosed in the year preceding the study (OR 7.87).
authors.affiliation: National Drug and Alcohol Research Centre, University of New South Wales, Australia. s.darke@unsw.edu.au
authors.forename: Shane
authors.initials: S
authors.lastname: Darke
authors.forename: Anna
authors.initials: A
authors.lastname: Williamson
authors.forename: Joanne
authors.initials: J
authors.lastname: Ross
authors.forename: Maree
authors.initials: M
authors.lastname: Teesson
mesh_terms: D000328:Adult; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D003710:Demography; D039721:Diagnostic and Statistical Manual of Mental Disorders; D062787:Drug Overdose; D005260:Female; D005500:Follow-Up Studies; D003932:Heroin / Q000009:adverse effects*; D006556:Heroin Dependence / Q000175:diagnosis / Q000534:rehabilitation*; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D012114:Residential Treatment; D016896:Treatment Outcome
chemical_list: D003932:Heroin