title: The effect of Gencydo injections on hayfever symptoms: a therapeutic causality report.
abstract: OBJECTIVE
  The aim of this study was to study the effect of Gencydo (Weleda AG, Arlesheim, Switzerland) injections on hayfever symptoms.
  
  
  METHODS
  This is a therapeutic causality report based on the practices of 13 Dutch general practitioners.
  
  
  METHODS
  Thirteen (13) patients with a mean history of hayfever with grass pollen allergy of 9 years duration, who in previous years used conventional hayfever medication because of the severity of symptoms during the pollen season.
  
  
  METHODS
  Gencydo injections were given in 12 patients before the onset of and during the grass pollen season, and in one patient during the grass pollen season only.
  
  
  METHODS
  Nasal and non-nasal hayfever symptom severity, use of rescue medication (antihistamines or corticosteroids), and subjective experiences of patients were used as outcome measures.
  
  
  RESULTS
  Nine (9) of 13 patients showed no increase of symptom severity during the so-called pollen season. Both the mean maximal total nasal symptom score per patient and the mean total nasal symptom score for the entire study group during the days with a grass pollen count >100 were mild. Percentages of individual "strong" or "severe" nasal symptom scores were low. There was no statistically significant difference in mean total nasal symptom score between the period when the pollen count was <100 and the period when it was >100. Conventional rescue medication for hayfever was used only eight times, all by one person. Nine (9) patients (69%) reported an improvement of symptoms (eight patients cited strong improvement and one patient noted slight improvement).
  
  
  CONCLUSIONS
  There are clear indications that Gencydo treatment was effective in a large subgroup of the research population.
authors.affiliation: Louis Bolk Instituut, Driebergen, The Netherlands. e.baars@louisbolk.nl
authors.forename: Erik W
authors.initials: EW
authors.lastname: Baars
authors.forename: Anja
authors.initials: A
authors.lastname: De Bruin
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000368:Aged; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects; D009297:Nasal Mucosa / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; C509896:Gencydo; D010936:Plant Extracts