High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women.
The Connective Tissue Disease Screening Questionnaire (CSQ), developed to screen populations for SLE and other CTDs, has been validated in a predominantly Caucasian population with hospital-based controls. We aimed to test the performance characteristics of the CSQ in an urban, predominantly African-American population. The CSQ was administered by interview to women recruited for a study of environmental risk factors and SLE, including 99 cases with SLE validated by medical record review and 202 healthy controls recruited from the community. Overall, 88% of subjects had African heritage, 6% were Hispanic and 4% were non-Hispanic Caucasian. Controls were more likely to report African heritage than cases (91% versus 82%, P = 0.001). Sensitivity for detecting SLE was 88% and specificity was 91%. In this study, where the prevalence of SLE was 33%, predictive value of a positive CSQ was 82% and predictive value of a negative CSQ was 94%. The CSQ has slightly lower sensitivity but greater specificity for SLE in an urban, predominantly African-American population with community-based controls compared with a Caucasian population with hospital-based controls. These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE.
Karlson
E W
EW
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ekarlson@partners.org
Costenbader
K H
KH
McAlindon
T E
TE
Massarotti
E M
EM
Fitzgerald
L M
LM
Jajoo
R
R
Husni
E
E
Wright
E A
EA
Pankey
H
H
Fraser
P A
PA
D000328:Adult; D001741:Black or African American; D005188:False Negative Reactions; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000208:ethnology; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D014505:Urban Population; D044465:White People