Class reunion: PTEN joins the nuclear crew.
Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.
Lian
Zenglin
Z
Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Di Cristofano
Antonio
A
D064413:3-Phosphoinositide-Dependent Protein Kinases; D002471:Cell Transformation, Neoplastic; D003593:Cytoplasm / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology; D051059:PTEN Phosphohydrolase / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology
D064413:3-Phosphoinositide-Dependent Protein Kinases; D009687:Nuclear Proteins; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; C578562:PDPK1 protein, human; C494929:PTEN protein, human