title: 99mTc-TRODAT-1 SPECT study in early Parkinson's disease and essential tremor.
abstract: OBJECTIVE
  The clinical differentiation between early Parkinson's disease (PD) and essential tremor (ET) could be difficult, therefore, the aim of this study was to investigate 99mTc-TRODAT-1 SPECT as an applicable tool in this field.
  
  
  METHODS
  99mTc-TRODAT-1 single photon emission computed tomography (SPECT) was performed in 10 healthy volunteers, 27 patients with idiopathic PD (Hoehn and Yahr 1-1.5) and 12 patients with ET. The ratio of striatal (99m)Tc-TRODAT-1 binding was calculated as the index of (striatum - occipital cortex)/occipital cortex.
  
  
  RESULTS
  Compared with the striatal 99mTc-TRODAT-1 uptake in the ET group (0.49 +/- 0.07) or healthy controls (0.54 +/- 0.18), there was a significant decrease in the bilateral striatums of early PD, with a greater reduction in the contralateral striatum (0.27 +/- 0.08) than ipsilateral one (0.36 +/- 0.10, P < 0.01). Its sensitivity and specificity of differentiating early PD from ET was 96.4% and 91.7% respectively.
  
  
  CONCLUSIONS
  99mTc-TRODAT-1 SPECT can detect the dysfunction of nigrostriatal system in patients with early PD and provided a feasible tool to help differentiate early PD from ET.
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. wangjian336@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: Y-P
authors.initials: YP
authors.lastname: Jiang
authors.forename: X-D
authors.initials: XD
authors.lastname: Liu
authors.forename: Z-P
authors.initials: ZP
authors.lastname: Chen
authors.forename: L-Q
authors.initials: LQ
authors.lastname: Yang
authors.forename: C-J
authors.initials: CJ
authors.lastname: Liu
authors.forename: J-D
authors.initials: JD
authors.lastname: Xiang
authors.forename: H-L
authors.initials: HL
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D042241:Early Diagnosis; D020329:Essential Tremor / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D012016:Reference Values; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014326:Tropanes
chemical_list: D015609:Organotechnetium Compounds; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1