title: Loss of 22q chromosome is related to glioma progression and loss of 10q.
abstract: Loss of heterozygosity (LOH) of chromosome 22q has been investigated in 160 gliomas. LOH at one or more microsatellite increased with increasing grade of the tumor (P < 0.01). LOH22q was more frequent in astrocytic tumors (37%) compared to mixed or oligodendroglial tumors (21%) (P = 0.02). LOH22q was correlated to 10q loss but not to 1p or 9p loss. Taken together, these data suggest that LOH22q is an alteration associated with malignant progression of gliomas.
authors.affiliation: Fédération de neurologie Mazarin, Groupe hospitalier Pitié-Salpétrière, 47-83 bd de l'Hôpital, 75013, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Laigle-Donadey
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Crinière
authors.forename: Alexandra
authors.initials: A
authors.lastname: Benouaich
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Lesueur
authors.forename: Karima
authors.initials: K
authors.lastname: Mokhtari
authors.forename: Khe
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002879:Chromosomes, Human, Pair 10; D002892:Chromosomes, Human, Pair 22; D018450:Disease Progression; D005819:Genetic Markers; D005910:Glioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016019:Survival Analysis
chemical_list: D005819:Genetic Markers