The topical protective effect of soybean-germ oil against UVB-induced cutaneous erythema: an in vivo evaluation.
The preparation and detailed composition of an oil newly extracted from pure soy germ (not less than 96 % hypocotyle) are presented. Experiments in vivo showed that soybean-germ oil (SGO) possesses a remarkable protective activity against UVB-induced skin inflammation, exceeding that of tocopherol acetate by a factor of 2. These results suggest that SGO might have interesting therapeutic and cosmetic applications in the management of skin diseases initiated, sustained, or exacerbated by an over production of free radicals.
Bonina
Francesco
F
Dipartimento di Scienze Farmaceutiche, Università di Catania, Catania, Italy.
Puglia
Carmelo
C
Avogadro
Milvio
M
Baranelli
Enzo
E
Cravotto
Giancarlo
G
D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D019540:Area Under Curve; D004890:Erythema / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D018546:Hypocotyl / Q000737:chemistry; D008297:Male; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D013024:Soybean Oil / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors; D024505:Tocopherols; D014466:Ultraviolet Rays; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D013473:Sunscreening Agents; D013024:Soybean Oil; D024502:alpha-Tocopherol; D024505:Tocopherols