title: [Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats].
abstract: OBJECTIVE
  To observe the effect of ginseng fruit saponins (GFS) on insulin sensitivity index in high fat-fed rats.
  
  
  METHODS
  An animal model of insulin resistance was established by injecting low dose of streptozotocin (STZ) in high fat-fed rats. Effect of GFS on insulin sensitivity was detected with glucose infusion rate (GIR) by euglycemic hyperinsulinemic clamp technique.
  
  
  RESULTS
  The level of fasting blood glucose and insulin in untreated group increased more significantly than that in normal control group (P<0.05, P<0.01), while the index of GIR decreased significantly (P<0.01). As compared with the untreated groupìthe parameters of GFS-treated groups were improved significantly in a dosage-dependent manner (P<0.05, P<0.01).
  
  
  CONCLUSIONS
  GFS can improve experimental insulin resistance in rats.
authors.affiliation: Department of Cardiovascular Diseases, Medical College, Jiamusi University, Jiamusi, Heilongjiang Province 154007, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Luo
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Yin
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yue-Rong
authors.initials: YR
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Da-Zhuo
authors.initials: DZ
authors.lastname: Shi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004041:Dietary Fats; D005638:Fruit / Q000737:chemistry; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D005894:Panax / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D012503:Saponins