title: Histamine release during adult cardiopulmonary bypass.
abstract: Histamine, an inflammatory mediator in its own right, may also be a marker for a more widespread systemic inflammatory process. In this study we have examined variations in plasma histamine concentrations produced during the course of cardiac surgery involving cardiopulmonary bypass, the relationship between these variations and intra-operative events. By assays of serum tryptase and CD-63 expression we have also attempted to identify the source of histamine. Histamine concentrations that were significantly raised from baseline level were demonstrated. These were elevated from the time of aortic cross-clamping and continued to be raised for 24 h postoperatively (p < 0.00625). This was associated with an increase in CD-63 expression (p < 0.025) (but not an increase in tryptase concentration) following aortic cross-clamping and protamine administration, suggesting that basophils are the source of histamine. 41% of patients had arrhythmias in the post bypass period. The rise in histamine levels was not related to the incidence of cardiac arrhythmias.
authors.affiliation: Wales College of Medicine, Cardiff University, and University Hospital of Wales, Cardiff, Wales, UK.
authors.forename: K M
authors.initials: KM
authors.lastname: Fayaz
authors.forename: S
authors.initials: S
authors.lastname: Pugh
authors.forename: S
authors.initials: S
authors.lastname: Balachandran
authors.forename: P S
authors.initials: PS
authors.lastname: Sudheer
authors.forename: J E
authors.initials: JE
authors.lastname: Hall
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D001145:Arrhythmias, Cardiac / Q000097:blood; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D005260:Female; D006632:Histamine / Q000097:blood; D006636:Histamine Release; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010980:Platelet Membrane Glycoproteins; D011183:Postoperative Complications / Q000097:blood; D012697:Serine Endopeptidases / Q000097:blood; D060149:Tetraspanin 30; D053802:Tryptases
chemical_list: D015703:Antigens, CD; C554586:CD63 protein, human; D018836:Inflammation Mediators; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30; D006632:Histamine; D012697:Serine Endopeptidases; D053802:Tryptases