title: Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: the Alaska Siberia project.
abstract: OBJECTIVE
  To test the hypothesis that the unusually low prevalences of insulin resistance (IR), metabolic syndrome (MS) and diabetes (DM) in Alaskan Eskimos, compared to American Indians, is related to the traditional Eskimo diet, high in C20-C22 omega-3 fatty acids (FAs). To determine if the relatively low blood pressures, low serum triglycerides and high HDL cholesterol levels in Eskimos result from high omega-3 FA consumption.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  We measured plasma FA concentrations in 447 Norton Sound Eskimos (35-74 years of age) and screened for DM, CHD and associated risk factors. A dietary assessment (24-hr recall) was obtained for comparison the day before the blood sampling.
  
  
  RESULTS
  Plasma omega-3 FA concentrations were highly correlated with dietary omega-3 FAs and HDL levels and inversely correlated with plasma levels of insulin, 2-h insulin (OGTT), HOMI-IR, 2-h glucose (OGTT), triglyceride levels and diastolic blood pressure.
  
  
  CONCLUSIONS
  High consumption of omega-3 FAs positively affects components of the MS, insulin sensitivity and glucose tolerance. This finding suggests that high consumption of C20-C22 omega-3 FAs protects against the development of the MS and glucose intolerance.
authors.affiliation: Department of Neurological Surgery, University of Virginia, Charlottesville 22908-0212, USA. se6b@virginia.edu
authors.forename: Sven O E
authors.initials: SO
authors.lastname: Ebbesson
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Risica
authors.forename: Lars O E
authors.initials: LO
authors.lastname: Ebbesson
authors.forename: John M
authors.initials: JM
authors.lastname: Kennish
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Tejero
mesh_terms: D000328:Adult; D000368:Aged; D000413:Alaska / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000208:ethnology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000208:ethnology; D004032:Diet / Q000706:statistics & numerical data*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test / Q000706:statistics & numerical data; D006801:Humans; D007328:Insulin / Q000097:blood; D004930:Inuit / Q000706:statistics & numerical data*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000208:ethnology*; D008875:Middle Aged; D009749:Nutrition Surveys; D012044:Regression Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio / Q000706:statistics & numerical data
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D015525:Fatty Acids, Omega-3; D007328:Insulin; D014280:Triglycerides