Ubiquitylation of ion channels.
Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ubiquitylation) plays an important role in the biogenesis of normal and defective channels.
Abriel
Hugues
H
Department of Pharmacology and Toxicology, University of Lausanne, Switzerland. Hugues.Abriel@unil.ch
Staub
Olivier
O
D020816:Amino Acid Motifs; D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D017510:Protein Folding; D025801:Ubiquitin / Q000378:metabolism*
D007473:Ion Channels; D025801:Ubiquitin