title: Search for critical loading condition of the spine--a meta analysis of a nonlinear viscoelastic finite element model.
abstract: The relative vulnerability of spinal motion segments to different loading combinations remains unknown. The meta-analysis described here using the results of a validated L2-L3 nonlinear viscoelastic finite element model was designed to investigate the critical loading and its effect on the internal mechanics of the human lumbar spine. A Box-Behnken experimental design was used to design the magnitude of seven independent variables associated with loads, rotations and velocity of motion. Subsequently, an optimization method was used to find the primary and secondary variables that influence spine mechanical output related to facet forces, disc pressure, ligament forces, annulus matrix compressive/shear stresses and anulus fibers strain. The mechanical responses with respect to the two most-relevant variables were then regressed linearly using the response surface quadratic model. Axial force and sagittal rotation were identified as the most-relevant variables for mechanical responses. The procedure developed can be used to find the critical loading for finite element models with multi input variables. The derived meta-models can be used to predict the risk associated with various loading parameters and in setting safer load limits.
authors.affiliation: #1, Section 1, Jen-Ai Road, Collage of Engineering and Collage of Medicine, Institute of Biomedical Engineering, National Taiwan University, Taipei, 100, Taiwan, ROC. jlwang@ntu.edu.tw
authors.forename: Jaw-Lin
authors.initials: JL
authors.lastname: Wang
authors.forename: Aboulfazl
authors.initials: A
authors.lastname: Shirazi-Adl
authors.forename: Mohamad
authors.initials: M
authors.lastname: Parnianpour
mesh_terms: D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology*; D008954:Models, Biological; D015233:Models, Statistical; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013119:Spinal Cord Injuries / Q000453:epidemiology* / Q000503:physiopathology*; D013314:Stress, Mechanical; D014783:Viscosity; D016474:Weight-Bearing