Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin.
We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produced a hemostatic effect and normalized some parameters of blood coagulation.
Golubeva
M G
MG
Department of Human and Animals Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. mgolubeva46@mail.ru
Grigoreva
M E
ME
Smirnova
M P
MP
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D000077144:Clopidogrel; D006487:Hemostasis / Q000187:drug effects; D006490:Hemostatics / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010979:Platelet Function Tests; D051381:Rats; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000494:pharmacology; D014667:Vasopressins / Q000737:chemistry*
D006490:Hemostatics; D010975:Platelet Aggregation Inhibitors; D014667:Vasopressins; D001127:Arginine Vasopressin; C015119:argipressin, des-GlyNH2(9)-; D000244:Adenosine Diphosphate; D000077144:Clopidogrel; D013988:Ticlopidine