title: New cytotoxic benzopyrans from the leaves of Mallotus apelta.
abstract: Two new benzopyrans 6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1'-oxo-3'(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1 D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC50: 0.49 microg/mL) and rhabdosarcoma (RD, IC50: 0.54 microg/mL), while compound 2 showed moderate activity against Hep-2 cell line (IC50, 4.22 microg/mL) by in vitro assay.
authors.affiliation: Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, Hanoi, Vietnam.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Dang
authors.forename: Ha Viet
authors.initials: HV
authors.lastname: Bao
authors.forename: Hoang Thanh
authors.initials: HT
authors.lastname: Huong
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Le Mai
authors.initials: le M
authors.lastname: Huong
authors.forename: Jung Joon
authors.initials: JJ
authors.lastname: Lee
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: C506377:6-(1'-oxo-3'(R)-hydroxy-butyl)-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran; C506375:6-(1'-oxo-3'(R)-methoxy-butyl)-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran; D001578:Benzopyrans; D010936:Plant Extracts