In vitro synergy of daptomycin plus rifampin against Enterococcus faecium resistant to both linezolid and vancomycin.
In vitro synergy testing of daptomycin plus rifampin was performed against 24 unique isolates of Enterococcus faecium resistant to both linezolid and vancomycin. Synergy testing showed that 21/24 (88%) were synergistic and 3/24 (12%) were indifferent by the Etest method. Time-kill assays revealed synergy for 18/24 (75%) and indifference for 6/24 (25%).
Pankey
George
G
Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, Louisiana 70121, USA. gpankey@ochsner.org
Ashcraft
Deborah
D
Patel
Nalini
N
D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D016984:Enterococcus faecium / Q000187:drug effects*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology*; D020713:Vancomycin Resistance / Q000235:genetics
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid; D017576:Daptomycin; D012293:Rifampin