title: Ras-related signaling pathways in valve development: ebb and flow.
abstract: Congenital heart defects affect approximately 1 in every 100 live births, and deficits in the formation of the mitral, tricuspid, and outflow tract valves account for 20-25% of all cardiac malformations. Mutations in genes that affect Ras signaling have been identified in individuals with congenital valve disease associated with Noonan syndrome and neurofibromatosis type 1. Dissection of Ras-related signaling pathways during valvulogenesis provides seminal insight into cellular and molecular mechanisms that contribute to congenital heart disease.
authors.affiliation: Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Research Foundation, Ohio, USA.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Yutzey
authors.forename: Melissa
authors.initials: M
authors.lastname: Colbert
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Robbins
mesh_terms: D000818:Animals; D047109:Fetal Development / Q000502:physiology; D006330:Heart Defects, Congenital / Q000235:genetics; D006351:Heart Valves / Q000196:embryology*; D006801:Humans; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D018631:ras Proteins