Recognition of tumor glycans by antigen-presenting cells.
C-type lectin receptors on antigen-presenting cells are potent antigen-uptake receptors with specificity for glycan structures. Glycosylation changes during malignant transformation create tumor-specific carbohydrate structures that interact with C-type lectins on dendritic cells. Recent findings revealed that tumor glycoproteins, such as carcinoembryonic antigen and MUC-1, indeed interact with the C-type lectins DC-SIGN and macrophage galactose-type lectin on antigen-presenting cells. The consequences for anti-cancer immunity or tolerance induction can be extrapolated from the function of C-type lectins in pathogen recognition and antigen presentation. In addition, in vivo studies in mice recently demonstrated the potency of targeting antigens to C-type lectins on antigen-presenting cells for anti-tumor vaccination strategies.
Aarnoudse
Corlien A
CA
Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, PO Box 7057, 1081 BT Amsterdam, The Netherlands.
Garcia Vallejo
Juan J
JJ
Saeland
Eiríkur
E
van Kooyk
Yvette
Y
D000818:Animals; D000938:Antigen-Presenting Cells / Q000737:chemistry / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000276:immunology; D006031:Glycosylation; D006801:Humans; D007167:Immunotherapy; D037181:Lectins, C-Type / Q000737:chemistry; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy; D011134:Polysaccharides / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*
D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D037181:Lectins, C-Type; D011134:Polysaccharides; D011956:Receptors, Cell Surface