title: The 2.3 genotype of ESRRA23 of the ERR alpha gene is associated with a higher BMI than the 2.2 genotype.
abstract: ERR alpha (NR3B1) is an orphan nuclear receptor believed to be involved in energy metabolism and obesity. A 23-base pair sequence in the 5'-flanking region of the ERR alpha gene, referred to as ESRRA23, is polymorphic in human chromosomes. Here, we investigated the influence of the ESRRA23 polymorphism on obesity in 703 Japanese individuals by analyzing indices of obesity and related lifestyle factors. The frequency of genotypes was similar to that reported in whites. The 2.3-genotype was associated with a significantly higher BMI than was the 2.2-genotype. An increased number of ESRRA23 repeats may be a genetic factor in human obesity.
authors.affiliation: National Institute of Health and Nutrition, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8636, Japan.
authors.forename: Yasutomi
authors.initials: Y
authors.lastname: Kamei
authors.forename: Htay
authors.initials: H
authors.lastname: Lwin
authors.forename: Kyoko
authors.initials: K
authors.lastname: Saito
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yoshiike
authors.forename: Osamu
authors.initials: O
authors.lastname: Ezaki
authors.forename: Heizo
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D008019:Life Style; D008297:Male; D011110:Polymorphism, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor