title: Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs.
abstract: The condensation of the C-10 methoxybipyrrole precursor (3) of prodigiosin with indoles and a related pyrrole derivative yields novel analogs of prodigiosin. Biological evaluation of these products revealed compounds that inhibit cancer cell proliferation from 50 nM to 50 microM.
authors.affiliation: ArQule Inc. 19 Presidential Way, Woburn, MA 01801-5140, USA. carmen.baldino@bioduro.com
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Baldino
authors.forename: Jonathan
authors.initials: J
authors.lastname: Parr
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Wilson
authors.forename: Shi-Chung
authors.initials: SC
authors.lastname: Ng
authors.forename: Daniel
authors.initials: D
authors.lastname: Yohannes
authors.forename: Harry H
authors.initials: HH
authors.lastname: Wasserman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry; D015394:Molecular Structure; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D011353:Prodigiosin