title: Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations.
abstract: A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. paul@tropmedres.ac
authors.forename: Paul N
authors.initials: PN
authors.lastname: Newton
authors.forename: Steven
authors.initials: S
authors.lastname: Ward
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Angus
authors.forename: Wirongrong
authors.initials: W
authors.lastname: Chierakul
authors.forename: Arjen
authors.initials: A
authors.lastname: Dondorp
authors.forename: Ronnatrai
authors.initials: R
authors.lastname: Ruangveerayuth
authors.forename: Kamolrat
authors.initials: K
authors.lastname: Silamut
authors.forename: Pramote
authors.initials: P
authors.lastname: Teerapong
authors.forename: Yupin
authors.initials: Y
authors.lastname: Suputtamongkol
authors.forename: Sornchai
authors.initials: S
authors.lastname: Looareesuwan
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011803:Quinine / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013785:Thailand; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D011803:Quinine