Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis.
Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.
Carpenter
Kristin J
KJ
Department of Pathology, University of Michigan Medical School, Rm. 5216B, Med. Sci. I, 1301 Catherine Road, Ann Arbor, MI 48109-0602, USA.
Buckland
Karen F
KF
Xing
Zhou
Z
Hogaboam
Cory M
CM
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D001228:Aspergillosis / Q000235:genetics / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D009503:Neutropenia / Q000235:genetics; D015533:Transcriptional Activation
D048868:Adaptor Proteins, Signal Transducing; C484963:Tyrobp protein, mouse