title: Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy.
abstract: OBJECTIVE
  To detect early diabetic damage in type 2 diabetes mellitus patients with no diabetic retinopathy (NDR) using optical coherence tomography (OCT) and to evaluate OCT as a clinical test.
  
  
  METHODS
  Thirty-two patients with NDR (n = 32) were enrolled. We examined retinal and retinal nerve fiber layer (RNFL) thickness using OCT. Two healthy normal populations were also enrolled for the retinal thickness (n = 48) and RNFL thickness (n = 34). Both OCT measurements were obtained in four areas (temporal, superior, nasal and inferior). The receiver operator characteristic (ROC) curve was generated to evaluate the predictor variables.
  
  
  RESULTS
  Comparing the normal and NDR eyes, retinal thickness significantly increased (p = 0.03) and RNFL thickness significantly decreased (p = 0.02) in the superior areas. The area under the ROC curve was 0.65 for the superior retinal thickness and 0.63 for the superior RNFL thickness.
  
  
  CONCLUSIONS
  Both OCT measurements can detect early retinal damage in NDR patients.
authors.affiliation: Department of Ophthalmology, Mie University, School of Medicine, Tsu, Japan. sugmochi@aqua.ocn.ne.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Mikio
authors.initials: M
authors.lastname: Sasoh
authors.forename: Masashi
authors.initials: M
authors.lastname: Ido
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Wakitani
authors.forename: Chisato
authors.initials: C
authors.lastname: Takahashi
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Uji
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis*; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D003941:Diagnostic Techniques, Ophthalmological; D006801:Humans; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D012372:ROC Curve; D012160:Retina / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*