title: [Incidence of cerebral ischemia in patients with suspected cervical artery dissection: first results of a prospective study].
abstract: OBJECTIVE
  Aim of this prospective study was to investigate the incidence of spontaneous cervical artery dissection (sCAD) and cerebral ischemia in patients with suspected sCAD by using a combined head-neck MR-imaging protocol.
  
  
  METHODS
  51 consecutive patients (24 m, 27 f, mean age 39.5 years, range 18 - 55 yrs) admitted to our stroke unit with suspected sCAD according to clinical criteria and age < 55 years underwent a combined head and neck MR examination within 24 hours of admission (Gyroscan Intera 1.5 T, Philips). Head MRI included ax FLAIR, ax T (1), ax DWI and TOF angiography (imaging time 12 min). Neck MRI consisted of ax T1w-TSE, T2w-TSE, contrast enhanced T1w-TSE and CE-MRA (imaging time 17 min). Three radiologists assessed both studies in consensus with regard to the presence of sCAD and acute ischemia.
  
  
  RESULTS
  One patient had to be excluded because of motion artefacts. In 17 of 50 patients sCAD was diagnosed, and in 20 of 50 patients cerebral ischemia. In 5 patients cerebral ischemia was caused by sCAD.
  
  
  CONCLUSIONS
  The proposed combined MR protocol allows imaging work-up of patients with suspected sCAD within approximately 30 min, resulting in conclusive information about the status of the extracranial vasculature and the presence of ischemia. The high incidence of patients with definite sCAD and the low incidence of cerebral ischemia indicates the necessity of an early definite diagnosis in order to start timely anticoagulation to prevent development of stroke.
authors.affiliation: Leibniz-Institut für Arteriosklerose-Forschung, Westfälische Wilhelms-Universität Münster. nasseni@uni-muenster.de
authors.forename: I
authors.initials: I
authors.lastname: Nassenstein
authors.forename: S C
authors.initials: SC
authors.lastname: Krämer
authors.forename: T
authors.initials: T
authors.lastname: Niederstadt
authors.forename: C
authors.initials: C
authors.lastname: Stehling
authors.forename: R
authors.initials: R
authors.lastname: Dittrich
authors.forename: G
authors.initials: G
authors.lastname: Kuhlenbäumer
authors.forename: E B
authors.initials: EB
authors.lastname: Ringelstein
authors.forename: W
authors.initials: W
authors.lastname: Heindel
authors.forename: R
authors.initials: R
authors.lastname: Bachmann
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D020215:Carotid Artery, Internal, Dissection / Q000175:diagnosis*; D005260:Female; D006801:Humans; D015994:Incidence; D002546:Ischemic Attack, Transient / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020521:Stroke / Q000517:prevention & control; D020217:Vertebral Artery Dissection / Q000175:diagnosis*
chemical_list: D000925:Anticoagulants