Clostridium perfringens enterotoxin damages the human intestine in vitro.
In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport changes that are not statistically significant.
Fernández Miyakawa
M E
ME
California Animal Health and Food Safety Laboratory-San Bernardino Branch, University of California-Davis, 105 W. Central Avenue, San Bernardino, CA 92408. mmiyakaw@cahfs.ucdavis.edu.
Pistone Creydt
V
V
Uzal
F A
FA
McClane
B A
BA
Ibarra
C
C
D003106:Colon / Q000187:drug effects* / Q000473:pathology; D004768:Enterotoxins / Q000633:toxicity*; D006801:Humans; D007082:Ileum / Q000187:drug effects* / Q000473:pathology; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*
D004768:Enterotoxins; C035598:enterotoxin, Clostridium