title: Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review.
abstract: Radiation induced meningiomas (RIM) are rare late complications in patients who have received high dose irradiation for brain tumors. The mean latency period for induction of RIM in most of the series is 18.7+/-10.2 years. There are only 9 reported cases of RIM following high dose cranial irradiation with unusually short latency periods of less than 5 years. Herein, we report a child diagnosed with RIM with an unusually short latency period of 14 months. An 11-year old male child underwent gross total resection of medulloblastoma. Following surgery he received high dose craniospinal irradiation. Postoperative computed tomography scan (CT scan) after 1 month did not show features of any residual tumor, recurrence or tumor at a new site. The child was asymptomatic for 14 months and then presented with complaints of headache and vomiting. CT scan head showed multiple solid homogenously enhancing lesions in bilateral basifrontal and right basitemporal region. Histopathology of the lesions turned out to be atypical meningioma.
authors.affiliation: Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, Uttar Pradesh, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Choudhary
authors.forename: Satyajit
authors.initials: S
authors.lastname: Pradhan
authors.forename: Mohammad Fakhrul
authors.initials: MF
authors.lastname: Huda
authors.forename: Sureswar
authors.initials: S
authors.lastname: Mohanty
authors.forename: Mohan
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000367:Age Factors; D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy*; D008579:Meningioma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D011879:Radiotherapy Dosage; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome