title: Commentary on the pleasures of solving impossible problems of experimental physiology.
abstract: This commentary presents a series of examples of "impossible experimental problems" that we have encountered over the years in addressing various challenging questions in physiology. We aim to show how stimulating the challenges of physiology can be and demonstrate how our naive invocation of methods from disparate fields of science and engineering has led to delightful resolutions of physiological challenges that were utterly new to this intrepid interdisciplinary researcher.
authors.affiliation: School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA. www2@cornell.edu
authors.forename: Watt W
authors.initials: WW
authors.lastname: Webb
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D004594:Electrophysiology; D006309:Hearing / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D021962:Membrane Microdomains; D008565:Membrane Proteins / Q000378:metabolism; D008853:Microscopy; D010827:Physiology / Q000266:history*; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins