Expression of TAp73 and DeltaNp73 isoform transcripts in thyroid tumours.
OBJECTIVE
This study was aimed to determine p73 status in thyroid tumours.


METHODS
Differential expression of the TAp73, DeltaTAp73 transcripts was measured in a panel of 60 thyroid malignancies by quantitative RT-PCR.


RESULTS
By comparison to normal thyroid tissue surrounding the tumours, we observed significant downregulation of TP73 transcripts in adenomas and in differentiated carcinomas. Correlations were found in normal tissue specimens between the expression of TAp73 and DeltaNp73 transcripts and that of p53, p14ARF p16INK4a, but these correlations were lost in carcinomas (PTC or FTC).


CONCLUSIONS
We have found significant variations of TAp73, DeltaNp73, p53, p14ARF p16INK4a, expressions and correlations between the expressions of those different genes in thyroid cancer.
Ferru
A
A
Laboratoire d'Oncologie Moléculaire EA3805, PBS, Cité Hospitalière de la Milétrie, Avenue du Recteur Pineau, 86021 Poitiers Cedex, France.
Denis
S
S
Guilhot
J
J
Gibelin
H
H
Tourani
J M
JM
Kraimps
J L
JL
Larsen
C J
CJ
Karayan-Tapon
L
L
D018263:Adenocarcinoma, Follicular / Q000737:chemistry*; D018249:Adenoma, Oxyphilic / Q000737:chemistry*; D002291:Carcinoma, Papillary / Q000737:chemistry*; D016022:Case-Control Studies; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000235:genetics; D005602:France; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009687:Nuclear Proteins / Q000032:analysis* / Q000235:genetics; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000235:genetics; D013964:Thyroid Neoplasms / Q000737:chemistry*; D014158:Transcription, Genetic; D025803:Tumor Suppressor Protein p14ARF / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D025521:Tumor Suppressor Proteins / Q000032:analysis* / Q000235:genetics
D019941:Cyclin-Dependent Kinase Inhibitor p16; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D020033:Protein Isoforms; D012333:RNA, Messenger; D025803:Tumor Suppressor Protein p14ARF; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins