title: Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA.
abstract: The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3' untranslated region (3' UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3' UTR. In Hzf-deficient mice, the dendritic localization of IP(3)RI mRNA and brain-derived neurotrophic factor-induced IP(3)RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP(3)RI, and may be involved in some aspects of synaptic plasticity.
authors.affiliation: Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Iijima
authors.forename: Takao
authors.initials: T
authors.lastname: Imai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kimura
authors.forename: Alan
authors.initials: A
authors.lastname: Bernstein
authors.forename: Hirotaka James
authors.initials: HJ
authors.lastname: Okano
authors.forename: Michisuke
authors.initials: M
authors.lastname: Yuzaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Okano
mesh_terms: D020413:3' Untranslated Regions / Q000378:metabolism / Q000502:physiology; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology*; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology; D002478:Cells, Cultured; D002531:Cerebellum / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism* / Q000502:physiology; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051379:Mice; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D011689:Purkinje Cells / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D012333:RNA, Messenger / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology; D013569:Synapses / Q000502:physiology; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D019208:Brain-Derived Neurotrophic Factor; D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011506:Proteins; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; C404217:Zfp385 protein, mouse