Deaggregation behavior of the phenol gemini derivatives.
The phenol gemini compounds were synthesized by rebuilding the substituents and lateral chain on the phenyl ring. Two parts of the molecules were connected by a spacer of hydrocarbon chain via ester groups. The deaggregation behaviors of target molecules were investigated by studying coaggregation behaviors, evaluating the deaggregating abilities in terms of fluorescence measurements, the measurements of their aggregation number and the effects on restraining the cell adhesion. In present cases, all of these experiments give the same results; that is, in these molecules, the longer branched methyl hydrocarbon chain and the combination of methoxy with hydroxyl groups on the phenyl ring possess the higher deaggregating abilities in the studied situation. The molecules with two hydrocarbon chains, i.e., the phenol gemini compounds, are more effective to deaggregate the aggregated probes than the molecules with one hydrocarbon chain. To find an effective deaggregator might be helpful to design the medicine for the cure of arteriosclerosis.
Chen
Jian
J
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Yang
Fan
F
Ji
Guo-Zhen
GZ
Yang
Hui
H
Shen
Zheng-Wu
ZW
Zhou
Xiu-Jia
XJ