title: Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes.
abstract: Brain deposits of amyloid beta peptide (Abeta) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Abeta is also present in peripheral blood. Here, we present evidence that circulating Abeta42 is subject to complement C3b-dependent adherence to complement receptor 1 (CR1) on erythrocytes, a classical set of mechanisms by which pathogens and proteins recognized as foreign are cleared from the bloodstream. Levels of Abeta42 targeted by this pathway differ significantly in AD compared to mild cognitive impairment and nondemented elderly controls.
authors.affiliation: L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA. joseph.rogers@sunhealth.org <joseph.rogers@sunhealth.org>
authors.forename: Joseph
authors.initials: J
authors.lastname: Rogers
authors.forename: Rena
authors.initials: R
authors.lastname: Li
authors.forename: Diego
authors.initials: D
authors.lastname: Mastroeni
authors.forename: Andrew
authors.initials: A
authors.lastname: Grover
authors.forename: Brian
authors.initials: B
authors.lastname: Leonard
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Ahern
authors.forename: Phillip
authors.initials: P
authors.lastname: Cao
authors.forename: Heather
authors.initials: H
authors.lastname: Kolody
authors.forename: Linda
authors.initials: L
authors.lastname: Vedders
authors.forename: William P
authors.initials: WP
authors.lastname: Kolb
authors.forename: Marwan
authors.initials: M
authors.lastname: Sabbagh
mesh_terms: D000544:Alzheimer Disease / Q000097:blood; D016229:Amyloid beta-Peptides / Q000097:blood*; D002448:Cell Adhesion / Q000276:immunology; D003176:Complement C3 / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D021381:Protein Transport / Q000276:immunology
chemical_list: D016229:Amyloid beta-Peptides; D003176:Complement C3; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)