title: Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation.
abstract: Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0.01) and disease-free survival (P = 0.02), resulting from increased relapse rate (P = 0.02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT.
authors.affiliation: Department of Haematology and BMT, Silesian Medical University, Katowice, Poland. sgiebel@poczta.onet.pl
authors.forename: Sebastian
authors.initials: S
authors.lastname: Giebel
authors.forename: Franco
authors.initials: F
authors.lastname: Locatelli
authors.forename: Jerzy
authors.initials: J
authors.lastname: Wojnar
authors.forename: Andrea
authors.initials: A
authors.lastname: Velardi
authors.forename: Tommaso
authors.initials: T
authors.lastname: Mina
authors.forename: Giovanna
authors.initials: G
authors.lastname: Giorgiani
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Krawczyk-Kulis
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Markiewicz
authors.forename: Iwona
authors.initials: I
authors.lastname: Wylezol
authors.forename: Jerzy
authors.initials: J
authors.lastname: Holowiecki
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D019337:Hematologic Neoplasms / Q000235:genetics / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006720:Homozygote; D006801:Humans; D007223:Infant; D008024:Ligands; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011971:Receptors, Immunologic / Q000235:genetics*; D054342:Receptors, KIR2DL1; D012008:Recurrence; D016019:Survival Analysis
chemical_list: D015236:HLA-C Antigens; C093100:KIR2DL1 protein, human; D008024:Ligands; D011971:Receptors, Immunologic; D054342:Receptors, KIR2DL1