title: Frosta: a new technology for making fast-melting tablets.
abstract: The fast-melting tablet (FMT) technology, which is known to be one of the most innovated methods in oral drug delivery systems, is a rapidly growing area of drug delivery. The initial success of the FMT formulation led to the development of various technologies. These technologies, however, still have some limitations. Recently, a new technology called Frosta (Akina) was developed for making FMTs. The Frosta technology utilises the conventional wet granulation process and tablet press for cost-effective production of tablets. The Frosta tablets are mechanically strong with friability of < 1% and are stable in accelerated stability conditions when packaged into a bottle container. They are robust enough to be packaged in multi-tablet vials. Conventional rotary tablet presses can be used for the production of the tablets and no other special instruments are required. Thus, the cost of making FMTs is lower than that of other existing technologies. Depending on the size, Frosta tablets can melt in < 10 s after placing them in the oral cavity for easy swallowing. The Frosta technology is ideal for wide application of FMTs technology to various drug and nutritional formulations.
authors.affiliation: Purdue University, Departments of Pharmaceutics and Biomedical Engineering, West Lafayette, IN 47907, USA.
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Yourong
authors.initials: Y
authors.lastname: Fu
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D005612:Freeze Drying; D006244:Hardness; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010969:Plastics / Q000737:chemistry; D016062:Porosity; D012995:Solubility; D013499:Surface Properties; D013607:Tablets; D013649:Taste; D013678:Technology, Pharmaceutical; D013718:Tensile Strength; D013997:Time Factors; D017155:Wettability; D014906:Wetting Agents / Q000737:chemistry
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations; D010969:Plastics; D013607:Tablets; D014906:Wetting Agents