Tissue regeneration. The past, the present and the future.
Tissue engineering has been a topic of extensive research over the last years. The ability of human body to regenerate tissue loss such as bone, cartilage, nerves, skin and muscle is limited leading often to amputations of limbs or functional disability. The isolation of mesenchymal stem cells (MSCs) and later the embryonic stem cells in conjunction with the advances made in cellular biology, tissue engineering, genetics and recombinant technology has initiated the development of new techniques and new therapeutic strategies allowing treatment of many pathological conditions providing restoration of tissue continuity and function.
Giannoudis
Peter V
PV
Department of Trauma and Orthopaedics, St James's University Hospital, School of Medicine, University of Leeds, Beckett Street, Leeds LS9 7TF, UK. pgiannoudi@aol.com
Pountos
Ippokratis
I
D016025:Bone Transplantation; D005544:Forecasting; D006801:Humans; D007511:Ischemia / Q000628:therapy; D009132:Muscles / Q000637:transplantation; D012038:Regeneration; D016038:Skin Transplantation; D017695:Soft Tissue Injuries / Q000628:therapy; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends