title: Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery.
abstract: In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery.
authors.affiliation: Research Center for Advanced Medicine, Nihon University School of Medicine, and Aoyama Hospital, Tokyo, Japan. hidai@med.nihon-u.ac.jp
authors.forename: Chiaki
authors.initials: C
authors.lastname: Hidai
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kawana
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Habu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kazama
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kawase
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Iwata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Thomas
authors.initials: T
authors.lastname: Quertermous
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kokubun
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D015815:Cell Adhesion Molecules; D018929:Cell Culture Techniques; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D008643:Mesentery / Q000098:blood supply* / Q000196:embryology; D051379:Mice; D008822:Mice, Transgenic; D008854:Microscopy, Electron; D009024:Morphogenesis; D018919:Neovascularization, Physiologic; D010641:Phenotype
chemical_list: D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; C491706:Edil3 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins