Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America.
Chronic lymphocytic leukemia (CLL) is frequent in the West, but rare in Korea. In this study, the frequency of chromosome aberration in Korean CLL patients was examined by applying interphase fluorescence in situ hybridization (FISH). Conventional cytogenetic test and FISH were performed on bone marrow aspirates obtained from 16 CLL patients. By applying DNA probes (Vysis, Downers Grove, IL, USA), the deletion in 11q22-23, 13q14, 13q34, and 17p13, and trisomy 12 were examined. With FISH, molecular cytogenetic aberration was detected in 10 of 16 patients [63%, 95% confidence interval (CI) 39-86], whereas with conventional cytogenetic test, chromosomal aberration was detected only in 2 out of 13 cases (15%, 95% CI 0-35). In total, the cases with one or more chromosomal aberrations were 11 out of 16 cases (69%, 95% CI 46-92). The most frequently detected aberration was the 13q14 deletion (69%, 95% CI 44-94), followed by trisomy 12 (19%, 95% CI 0-38) and 11q22 deletion (14%, 95% CI 0-33). No deletion in 17p13 was observed. In conclusion, CLL in Korean is a heterogeneous genetic disorder, showing similar genetic changes in Europe and North America.
Chang
Yoon Hwan
YH
Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, and Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Park
Junwan
J
Kim
Hee Chan
HC
Chun
Hong Ku
HK
Kim
Young Ree
YR
Kim
Myungshin
M
Han
Kyungja
K
Lee
Je-Hwan
JH
Lee
Kyoo-Hyung
KH
Cho
Han Ik
HI
Lee
Yun Song
YS
Lee
Dong Soon
DS
D000368:Aged; D002872:Chromosome Deletion; D002877:Chromosomes, Human / Q000235:genetics*; D005060:Europe; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007723:Korea; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009656:North America; D014314:Trisomy / Q000235:genetics*