title: Association of lipid profile with echocardiographic Wilkins score in patients with moderate to severe mitral stenosis: possible impact on prognosis.
abstract: BACKGROUND
  Association of valvular heart disease and lipid profile might be important as in the case of aortic stenosis. However, it has not been so far considered in detail the probable association of other valvular diseases, particularly of mitral stenosis (MS) with lipid profile. In our study, we aimed to search possible association of echocardiographic mitral valve score, evaluated according to Wilkins score, with lipid parameters in a group of patients with mitral stenosis, who were referred for possible percutaneous balloon valvuloplasty.
  
  
  METHODS
  We retrospectively reviewed 401 patients (316 female, 85 male), who were referred as possible candidates for PMBV, with moderate to severe MS of predominantly rheumatic origin. Mitral valve was evaluated according to Wilkins score by an experienced author as indicated.
  
  
  RESULTS
  Mean age of all patients was 36.6+/-11.3 years, and was not different in both genders. Mean mitral valve area was 1+/-0.1 mm2. Considering all patients, total Wilkins score was significantly, but mildly correlated with ratio of total/HDL cholesterol ratio (r=0.174, p=0.02). Presence of more than one recurrent attack of rheumatic fever, narrow mitral valve area, high total/HDL cholesterol and being male were independent predictors of poor echocardiographic Wilkins score (>8).
  
  
  CONCLUSIONS
  We think that Wilkins echocardiographic score of mitral stenosis, particularly of leaflet thickening, might well be associated with serum lipids, probably as the same extent does aortic stenosis.
authors.affiliation: Yuksek Ihtisas Education and Research Hospital, Cardiology Clinic, Sihhiye, Ankara, Turkey. cardioceptor@ttnet.net.tr
authors.forename: Mehmet Birhan
authors.initials: MB
authors.lastname: Yilmaz
authors.forename: Burcu
authors.initials: B
authors.lastname: Demirkan
authors.forename: Vedat
authors.initials: V
authors.lastname: Caldir
authors.forename: Yesim
authors.initials: Y
authors.lastname: Guray
authors.forename: Umit
authors.initials: U
authors.lastname: Guray
authors.forename: Hatice
authors.initials: H
authors.lastname: Sasmaz
authors.forename: Sule
authors.initials: S
authors.lastname: Korkmaz
mesh_terms: D000328:Adult; D002404:Catheterization; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging; D008946:Mitral Valve Stenosis / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000628:therapy; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D014463:Ultrasonography
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides