title: The immunopharmacological properties of transforming growth factor beta.
abstract: Transforming growth factor-beta (TGF-beta) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-betas in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-betas is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.
authors.affiliation: Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P.R. China. yyle@sibs.ac.cn
authors.forename: Yingying
authors.initials: Y
authors.lastname: Le
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yu
authors.forename: Lingfei
authors.initials: L
authors.lastname: Ruan
authors.forename: Oumei
authors.initials: O
authors.lastname: Wang
authors.forename: Dongfei
authors.initials: D
authors.lastname: Qi
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Lu
authors.forename: Yan
authors.initials: Y
authors.lastname: Kong
authors.forename: Kun
authors.initials: K
authors.lastname: Cai
authors.forename: Shanshan
authors.initials: S
authors.lastname: Pang
authors.forename: Xianglin
authors.initials: X
authors.lastname: Shi
authors.forename: Ji Ming
authors.initials: JM
authors.lastname: Wang
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology / Q000503:physiopathology; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
chemical_list: D007166:Immunosuppressive Agents; D016212:Transforming Growth Factor beta