title: A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line.
abstract: Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.
authors.affiliation: Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Furutani
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takeyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koutoku
authors.forename: Saya
authors.initials: S
authors.lastname: Ito
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Taniguchi
authors.forename: Eriko
authors.initials: E
authors.lastname: Suzuki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kudoh
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shibasaki
authors.forename: Hisataka
authors.initials: H
authors.lastname: Shikama
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kato
mesh_terms: D000728:Androgens / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008024:Ligands; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D034741:RNA, Small Interfering / Q000494:pharmacology; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology*
chemical_list: D000728:Androgens; D008024:Ligands; D034741:RNA, Small Interfering; D011944:Receptors, Androgen