title: Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor.
abstract: We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.
authors.affiliation: Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy. andrea.ferrari@istitutotumori.mi.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrari
authors.forename: Federica
authors.initials: F
authors.lastname: Grosso
authors.forename: Silvia
authors.initials: S
authors.lastname: Stacchiotti
authors.forename: Cristina
authors.initials: C
authors.lastname: Meazza
authors.forename: Elena
authors.initials: E
authors.lastname: Zaffignani
authors.forename: Alfonso
authors.initials: A
authors.lastname: Marchianò
authors.forename: Michela
authors.initials: M
authors.lastname: Casanova
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D044963:Biopsy, Fine-Needle; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D018365:Neoplasm, Residual; D011859:Radiography; D012074:Remission Induction; D012208:Rhabdomyosarcoma / Q000188:drug therapy; D018228:Sarcoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D003520:Cyclophosphamide; D000077235:Vinorelbine