title: Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida.
abstract: Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five cycloartane triterpenoids isolated from the EtOAc fraction. Compounds (1,2,3) showed moderate cytotoxic activity on R-HepG2 cells and drug resistant sub line R-HepG2 but exhibited less toxicity against primary cultured normal mouse hepatocytes. Compounds (4) and (5) were inactive on all tested cell lines.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100094, PR China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Tian
authors.forename: Rui Le
authors.initials: RL
authors.lastname: Pan
authors.forename: Jianyong
authors.initials: J
authors.lastname: Si
authors.forename: Pei Gen
authors.initials: PG
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002460:Cell Line; D031885:Cimicifuga / Q000737:chemistry*; D006027:Glycosides; D022781:Hepatocytes / Q000187:drug effects*; D007810:Lanosterol / Q000031:analogs & derivatives; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C485277:cimifoetiside IV; D007810:Lanosterol; C085352:cycloartane