[Modifying properties of 2,5-diphenyloxazole during low-dose X-ray exposure of mice].
The ability of 2,5-diphenyloxazole (DPO) to modify biological consequences of the X-rays irradiation of mice was studied with a dose of 16 cGy at the administration of the agent in a wide range of concentrations before or after irradiation was studied. It was shown that the administration of the agent in doses 9.9 x 10(-3)-9.8 mg/kg 35-60 min before irradiation causes a reliable decrease in the spleen mass within 1 month after the action; for the dose 1 mg/kg, it causes the tendency to decrease of the content of lipid peroxidation (LPO) products; the dose 9.8 mg/kg causes a decrease in the cell-free DNA amount in blood plasma of mice. The administration of DPO before irradiation causes changes in the scale and direction of the correlation between the DNA and LPO products contents in blood plasma of irradiated mice compared with the control. The administration of DPO 15-60 min after irradiation do not cause any reliable changes in the investigated parameters. The aviability of the study of the radioprotective properties of the DPO derivatives as agents with a nontraditional character of action is supposed.
Shishkina
L N
LN
Smotriaeva
M A
MA
Kozlov
M V
MV
Kushnireva
E V
EV
Dukhovich
F S
FS
Noskov
V G
VG
D000818:Animals; D004247:DNA / Q000097:blood; D004307:Dose-Response Relationship, Radiation; D005260:Female; D015227:Lipid Peroxidation; D051379:Mice; D010080:Oxazoles / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D014965:X-Rays
D010080:Oxazoles; D004247:DNA; C009012:2,5-diphenyloxazole