The application of plasma 1,5-anhydro-D-glucitol for monitoring type 2 diabetic patients.
OBJECTIVE
Recent data have suggested that effective control of postprandial blood glucose can reduce the risk of macroangiopathic complications of diabetes, especially cardiovascular risk. 1,5-Anhydro-D-glucitol (1,5-AG) has been proposed as a marker of short-term hyperglycaemic excursions. We aimed to evaluate its usefulness in patients with type 2 diabetes and have attempted to indicate when 1,5-AG monitoring should be used in ordinary diabetes care settings.


METHODS
The study group consisted of 130 type 2 diabetic patients aged 36-69 years. 1,5-AG plasma level, HbA_1c concentrations and daily glucose profile were measured. Mean blood glucose (MBG), M-value were calculated and maximal daily glycaemia (MxG) was established as indicators of short-term hyperglycaemic episodes.


RESULTS
1,5-AG plasma level was negatively and HbA_1c was positively correlated with fasting glycaemia (FG), MBG, M-value and MxG. Multivariate regression analysis revealed that 1,5-AG plasma level is determined by MxG only, while FG determined HbA_1c concentration in blood. The analysis of 1,5-AG level and HbA_1c distributions in well and poorly controlled patients revealed that persons with low HbA_1c values may have decreased 1,5-AG plasma level.


CONCLUSIONS
1,5-AG plasma level monitoring is the useful method to identify well controlled, exclusively based on HbA_1c levels type 2 diabetic patients with transient hyperglycaemia, accordingly patients at high risk of macroangiopathic complications.
Dworacka
Marzena
M
Department of Pharmacology Poznan University of Medical Sciences, Poznan, Poland. mdworac@am.poznan.pl
Winiarska
Hanna
H
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015190:Blood Glucose Self-Monitoring; D002319:Cardiovascular System / Q000473:pathology; D003847:Deoxyglucose / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis
D001786:Blood Glucose; D003847:Deoxyglucose; D005947:Glucose; D006442:Glycated Hemoglobin; C006584:1,5-anhydroglucitol