title: The use of central neuraxial techniques in parturients with factor V leiden mutation.
abstract: The factor V Leiden (FVL) mutation is a leading cause of thrombosis, particularly during pregnancy. During pregnancy, women with thrombotic disorders including FVL are often considered candidates for antepartum anticoagulation with low molecular weight heparin. Pregnancy complications related to thrombosis and the unpredictable timing of labor cause unique challenges with regard to the provision of regional anesthesia. A patient with heterozygotic FVL presenting with thrombotic disease and a complicated anticoagulation status lead us to review 16 additional parturients with FVL. This report focuses on the anesthetic implications that arise in parturients with FVL. We recommend that anesthesiologists be made aware of FVL patients before their due date, anticoagulation with low molecular weight heparin should be transitioned to unfractionated heparin before the 38th gestational week, and multidisciplinary collaborative investigation and care should continue for this disorder.
authors.affiliation: Departments of Anesthesia, Perioperative and Pain Medicine, and Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Miriam J
authors.initials: MJ
authors.lastname: Harnett
authors.forename: Mary E
authors.initials: ME
authors.lastname: Walsh
authors.forename: Thomas F
authors.initials: TF
authors.lastname: McElrath
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Tsen
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000379:methods*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D009407:Nerve Block / Q000379:methods*; D017354:Point Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: C095381:factor V Leiden; D005165:Factor V; D006493:Heparin