Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromsø study.
There are receptors for parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D in the brain, and there are clinical and experimental data indicating that PTH and vitamin D may affect cerebral function. In the present study 21 subjects who both in the 5th Tromsø study and at a follow-up examination fulfilled criteria for secondary hyperparathyroidism (SHPT) without renal failure (serum calcium < 2.40 mmol/L, serum PTH > 6.4 pmol/L, and normal serum creatinine) and 63 control subjects were compared with tests for cognitive and emotional function. Those in the SHPT group had significantly impaired performance in 3 of 14 cognitive tests (Digit span forward, Stroop test part 1 and 2, and Word association test (FAS)) as compared with the controls, and also had a significantly higher depression score at the Beck Depression Inventory (BDI) (items 1-13). In a multiple linear regression model, a high serum PTH level was significantly associated with low performance at the Digit span forward, Stroop test part 1 and 2, and Digit Symbol tests. A low level of serum 25-hydroxyvitamin D was significantly associated with a high depression score. In conclusion, a deranged calcium metabolism appears to be associated with impaired function in several tests of neuropsychological function.
Jorde
Rolf
R
Department of Internal Medicine, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway. rolf.jorde@unn.no
Waterloo
Knut
K
Saleh
Farahnaz
F
Haug
Egil
E
Svartberg
Johan
J
D000328:Adult; D000339:Affect / Q000502:physiology; D000368:Aged; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000097:blood; D003071:Cognition / Q000502:physiology; D003863:Depression / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood* / Q000523:psychology*; D008297:Male; D008568:Memory / Q000502:physiology; D008570:Memory, Short-Term / Q000502:physiology; D008603:Mental Health; D008875:Middle Aged; D009483:Neuropsychological Tests; D009664:Norway / Q000453:epidemiology; D010281:Parathyroid Hormone / Q000097:blood*; D014705:Verbal Behavior; D014888:Wechsler Scales; D014936:Word Association Tests
D010281:Parathyroid Hormone; D002117:Calcitriol; D002118:Calcium