Impact of dose and volume on radiation-induced mucositis.
There is a relationship between a given radiation dose and the resulting biological effect in the management of head and neck cancer. Radiation mucositis represents a frequent complication in cancer chemoradiation. Its prevention and treatment are major goals in radiation therapy schedules. Critical tissues can be spared using high conformal radiation therapy (3DCRT) based on consensus guidelines for target volume. Current approaches to radiation mucositis with respect to the dose and volume impact are illustrated. The monitoring system of late toxicity used by the authors is presented.
Mantini
Giovanna
G
Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico "A. Gemelli", Roma, Italy. gmantini@rm.unicatt.it
Manfrida
Stefania
S
Cellini
Francesco
F
Giammarino
Daniela
D
Petrone
Adelina
A
Vitucci
Pasquale
P
Cellini
Numa
N
D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D009061:Mouth Mucosa / Q000528:radiation effects*; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D013280:Stomatitis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control