Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives.
The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin.
Nam
Ghilsoo
G
Biochemicals Research Center, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul, Republic of Korea.
Kang
Tae Won
TW
Shin
Jung Hyu
JH
Choi
Kyung Il
KI
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D017291:Clarithromycin / Q000494:pharmacology; D015195:Drug Design; D004917:Erythromycin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry*; D005765:Gastrointestinal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010091:Oximes / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D004987:Ethers; D005765:Gastrointestinal Agents; D010091:Oximes; D004917:Erythromycin; D017291:Clarithromycin