[Low ability of blood lymphocytes to produce interferon-gamma in patients with idiopathic prolapse of mitral valve].
OBJECTIVE
To examine lymphocyte ability to synthetize interferon-gamma in patients with mitral prolapse (MP).


METHODS
The diagnosis of MP was made in 75 patients at echocardiography. ECG monitoring was made and the study of the ability of blood lymphocytes to produce IFN-gamma (If-g).


RESULTS
The ability to produce If-g was diminished. This phenomenon is associated with chronic inflammation, autonomic disregulation of cardiac activity, depends on gender.


CONCLUSIONS
Cytokine modulates metabolism of connective tissue in MP so If-g may participate in MP pathogenesis. Therefore, If-g and/or its inductors may prevent some MP-related complications due to its deficiency.
Surkina
I D
ID
Gurevich
K G
KG
Mel'nik
O O
OO
Akatova
E V
EV
Stepura
O B
OB
Pak
L S
LS
Martynov
A I
AI
D000328:Adult; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008945:Mitral Valve Prolapse / Q000276:immunology* / Q000378:metabolism
D007371:Interferon-gamma