[Immunoregulatory cytokines and chronization of type C hepatitis: matching of clinical and immunological manifestations].
The study demonstrates significant changes of cytokine-producing ability of mononuclear blood leucocytes in type 'hepatitis, correlating with the degree of hepatic lesion. The results showed that various morphologic types of chronic virus type C hepatitis were associated with disbalance in production of pro- and antiinflammatory cytokines, i.e. decrease of tumor necrosis factor (TNF)-alpha concentration and a significant rise of interleukin (IL)-4 and IL-10 concentations, which were the most prominent in cases of severe hepatic fibrosis and high histologic activity of hepatitis. The study established a direct correlation between increase of the ability of mononuclear blood leucocytes to synthesize IL-4, and the progress of the pathologic process.
Naslednikova
I O
IO
Beloborodova
E V
EV
Riazantseva
N V
NV
Beloborodova
E I
EI
Novitskiĭ
V V
VV
Chernogoriuk
G E
GE
Purlik
I L
IL
Belokon'
V V
VV
Antoshina
M A
MA
Sima
A P
AP
D000293:Adolescent; D000328:Adult; D016145:Endoscopy, Digestive System / Q000379:methods; D005260:Female; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4