Experimental reproduction of proliferative enteropathy and the role of IFN-gamma in protective immunity against Lawsonia intracellularis in mice.
Proliferative enteropathy was reproduced in IFN-gamma receptor knockout (IFN-gamma R-) mice by experimental infection with Lawsonia intracellularis (L. intracellularis). The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However, high levels of IFN-gamma were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-gamma produced in the infected mice should have been utilized by it's receptor to elicit protective immune responses against L. intracellularis infections.
Go
Yun-Young
YY
Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
Lee
Jeong-Keun
JK
Ye
Jeong-Yong
JY
Lee
Joong-Bok
JB
Park
Seung-Yong
SY
Song
Chang-Seon
CS
Kim
Soo-Ki
SK
Choi
In-Soo
IS
D000818:Animals; D004279:DNA, Viral; D045824:Desulfovibrionaceae Infections / Q000276:immunology* / Q000382:microbiology; D007371:Interferon-gamma / Q000276:immunology*; D007410:Intestinal Diseases / Q000276:immunology* / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology; D020639:Lawsonia Bacteria / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D018345:Mice, Knockout; D016133:Polymerase Chain Reaction; D017471:Receptors, Interferon / Q000502:physiology; D000096743:Interferon gamma Receptor
D004279:DNA, Viral; D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor