title: Impact of dose and volume on radiation-induced mucositis.
abstract: There is a relationship between a given radiation dose and the resulting biological effect in the management of head and neck cancer. Radiation mucositis represents a frequent complication in cancer chemoradiation. Its prevention and treatment are major goals in radiation therapy schedules. Critical tissues can be spared using high conformal radiation therapy (3DCRT) based on consensus guidelines for target volume. Current approaches to radiation mucositis with respect to the dose and volume impact are illustrated. The monitoring system of late toxicity used by the authors is presented.
authors.affiliation: Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico "A. Gemelli", Roma, Italy. gmantini@rm.unicatt.it
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mantini
authors.forename: Stefania
authors.initials: S
authors.lastname: Manfrida
authors.forename: Francesco
authors.initials: F
authors.lastname: Cellini
authors.forename: Daniela
authors.initials: D
authors.lastname: Giammarino
authors.forename: Adelina
authors.initials: A
authors.lastname: Petrone
authors.forename: Pasquale
authors.initials: P
authors.lastname: Vitucci
authors.forename: Numa
authors.initials: N
authors.lastname: Cellini
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D009061:Mouth Mucosa / Q000528:radiation effects*; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D013280:Stomatitis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control