title: Nine cases of accidental exposure to dimethyl sulphate--a potential chemical weapon.
abstract: Dimethyl sulphate (DMS) is an innocuous appearing, widely used, and highly toxic chemical. It is used both as a methylating agent in industrial chemical synthesis and in medical laboratories for chemical cleavage of DNA. It is readily absorbed through the skin, mucous membranes, and gastrointestinal tract. Delayed toxicity allows potentially fatal exposures to occur prior to development of any warning symptoms. Toxicity is manifested initially by mucosal inflammation of eyes, nose, oropharynx, and airways. This can progress to severe airway oedema and necrosis, and non-cardiogenic pulmonary oedema. Other systemic effects include convulsions, delirium, coma, and renal, hepatic, and cardiac failure. All these features make DMS a potential chemical weapon. We report nine cases of varying degrees of inhalational exposure to DMS, occurring as a result of a single chemical spillage incident in the United Kingdom. Industrial poisoning is surprisingly rare and there are few previous reports in the literature outside China.
authors.affiliation: Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, United Kingdom. James.Rippey@rlbuht.nhs.uk
authors.forename: J C R
authors.initials: JC
authors.lastname: Rippey
authors.forename: M I
authors.initials: MI
authors.lastname: Stallwood
mesh_terms: D000062:Accidents, Occupational; D000328:Adult; D000477:Alkylating Agents / Q000506:poisoning*; D005128:Eye Diseases / Q000139:chemically induced; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*; D012140:Respiratory Tract Diseases / Q000139:chemically induced; D013463:Sulfuric Acid Esters / Q000506:poisoning*
chemical_list: D000477:Alkylating Agents; D013463:Sulfuric Acid Esters; C007482:dimethyl sulfate