title: Eye movement abnormalities in stiff person syndrome.
abstract: The authors describe a 38-year-old woman with stiff person syndrome (SPS) and gaze-holding nystagmus, limited abduction, vertical and horizontal ocular misalignment, deficient smooth pursuit, and impaired saccade initiation. There was no evidence of ocular myasthenia, indicating that abnormalities of ocular motor function can occur as a primary manifestation of SPS, perhaps from depletion of GABA.
authors.affiliation: Beckman Vision Center, University of California, San Francisco, CA 94143-0730, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Economides
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Horton
mesh_terms: D000328:Adult; D001284:Atrophy / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D001933:Brain Stem / Q000378:metabolism / Q000503:physiopathology; D002526:Cerebellar Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005968:Glutamate Decarboxylase / Q000172:deficiency / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009128:Muscle Spasticity / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D009433:Neural Inhibition / Q000276:immunology; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology; D009460:Neurologic Examination; D009759:Nystagmus, Pathologic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D009801:Oculomotor Muscles / Q000294:innervation / Q000503:physiopathology*; D016750:Stiff-Person Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase