title: Pyrrolopyridazine MEK inhibitors.
abstract: The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.
authors.affiliation: Bristol-Myers Squibb, Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA. zhong.chen@bms.com
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Soong-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Barbosa
authors.forename: Tram
authors.initials: T
authors.lastname: Huynh
authors.forename: David R
authors.initials: DR
authors.lastname: Tortolani
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Leavitt
authors.forename: Donna D
authors.initials: DD
authors.lastname: Wei
authors.forename: Veeraswamy
authors.initials: V
authors.lastname: Manne
authors.forename: Carolyn S
authors.initials: CS
authors.lastname: Ricca
authors.forename: Johnni
authors.initials: J
authors.lastname: Gullo-Brown
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poss
authors.forename: Wayne
authors.initials: W
authors.lastname: Vaccaro
authors.forename: Mark E
authors.initials: ME
authors.lastname: Salvati
mesh_terms: D000215:Acylation; D000588:Amines / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D000814:Aniline Compounds; D004791:Enzyme Inhibitors; D011724:Pyridazines; D011758:Pyrroles; C508945:Pyrrolopyridazine; C062482:pyridazine; D020929:Mitogen-Activated Protein Kinase Kinases; C023650:aniline