Allogeneic peripheral blood stem cell transplant (PBSCT) using anti-IL2 receptor antibody Daclizumab for the prevention of acute graft versus host disease in steroid refractory Diamond Blackfan anaemia: a case report.
The case report of a 2 year old boy with steroid refractory DBA, treated with allogeneic PBSCT from an HLA matched sibling is presented. Anti-IL2 receptor antibody Daclizumab was used as a prophylaxis for graft versus host disease (GvHD). Complete recovery without any evidence of GvHD ensued.
Shamsi
Tahir Sultan
TS
Bismillah Taqee Institute of Health Sciences and Blood Diseases Centre, Karachi, Pakistan.
Irfan
Mohammad
M
Farzana
Tasneem
T
Ansari
Saqib Hussain
SH
Ahmad
Ghazala
G
Shakoor
Nazmeen
N
Baig
Mirza Irfan
MI
D000208:Acute Disease; D029503:Anemia, Diamond-Blackfan / Q000188:drug therapy / Q000601:surgery*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000077561:Daclizumab; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D015375:Receptors, Interleukin-2 / Q000037:antagonists & inhibitors* / Q000097:blood
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005938:Glucocorticoids; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D015375:Receptors, Interleukin-2; D000077561:Daclizumab