Fractal and noisy CBV dynamics in humans: influence of age and gender.
The complexity of spontaneous cerebral blood volume (CBV) fluctuations can emerge from random, fractal, or chaotic processes. Our aims were to define the contribution of these patterns to the observed complexity and to evaluate the effect of age and gender on it. The total hemoglobin content as the measure of CBV was monitored by near-infrared spectroscopy on volunteers (men n = 19, age = 20 to 78 years; women n = 23, age = 21 to 79 years). Random and fractal patterns were distinguished by the spectral index (beta). Chaos was identified by surrogate analysis of the correlation dimension (a static chaotic parameter, the dimension of the correlation integral) and the largest Lyapunov exponent (a dynamic chaotic parameter, the rate of exponential divergence of the system states from a perturbed initial condition over the chaotic attractor). In spontaneous CBV fluctuations, both fast random and slow fractal dynamics are present separately in their spectra by a cutoff frequency, f'. Below f' the pattern is fractal, in that power rises inversely with frequency as 1/f(beta). f' decreases with age in men and women alike (F1: up to 0.12+/-0.06 Hz versus F2: up to 0.05+/-0.04 Hz at P = 0.015, and M1: up to 0.16+/-0.05 Hz versus M2: up to 0.11+/-0.04 Hz at P = 0.044). Neither pre- nor postmenopausal age groups (1 and 2, respectively) showed a (low)beta gender difference. Surrogate analysis showed that CBV dynamics cannot be characterized on the grounds of deterministic chaos. Cerebral blood volume fluctuates in a complex, bimodal manner in humans, in that the fast dynamics has no structure, while the slow dynamics exhibits a self-similar, that is, fractal temporal structure. The range of fluctuation amplitudes produced by fractal dynamics is always larger than that of random fluctuations, and it shrinks with an altered structuring in aging women only.
Eke
Andras
A
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary. eke@elet2.sote.hu
Hermán
Péter
P
Hajnal
Márton
M
D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D017709:Fractals; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D012016:Reference Values; D012680:Sensitivity and Specificity; D012737:Sex Factors; D019265:Spectroscopy, Near-Infrared / Q000379:methods
D006454:Hemoglobins