title: Plasma cell leukemia: case report of a rare and aggressive variant of multiple myeloma.
abstract: Plasma cell leukemia (PCL) is a rare disease and is the least common variant of multiple myeloma accounting for 2-3% of all plasma cell dyscrasias. We report a patient who presented with history of high grade fever, weakness, palpitations, loss of appetite, bone pains and mental confusion for twenty days. Initial evaluation revealed plasmacytosis with blood plasma cell count of 5184/cumm. His hemoglobin (Hb) was 11.3 gm/dl, platelets were 75000/cumm and total leucocyte count (TLC) was 21600/cumm (24% plasma cells). Bone marrow examination revealed >60% plasmablasts. Serum LDH was high at 3117 U/L and serum calcium was also elevated at 13.9 mg/dl. A diagnosis of PCL was made and the patient was started on treatment for hypercalcaemia with Melphalan/Prednisolone regime along with supportive care. Patient deteriorated very rapidly despite treatment and died on the eighth day. A detailed report of this case and a review of PCL is presented here.
authors.affiliation: Department of Medical Oncology, Khyber Teaching Hospital and Post-Graduate Medical Institute, Hayatabad Medical Complex, Peshawar.
authors.forename: Abid
authors.initials: A
authors.lastname: Jameel
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D007958:Leukocyte Count; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D010950:Plasma Cells / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D018906:Antineoplastic Agents, Alkylating; D005938:Glucocorticoids; D011239:Prednisolone; D008558:Melphalan