Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis.
A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one of three strains of H. hepaticus: type strain Hh3B1, which contains the complete PAI, and strains HhNET and HhG, which lack all or large parts of HHGI1, respectively. Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1.
Boutin
Samuel R
SR
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-825C, Cambridge, MA 02139, USA.
Shen
Zeli
Z
Rogers
Arlin B
AB
Feng
Yan
Y
Ge
Zhongming
Z
Xu
Sandy
S
Sterzenbach
Torsten
T
Josenhans
Christine
C
Schauer
David B
DB
Suerbaum
Sebastian
S
Fox
James G
JG
D000818:Animals; D005260:Female; D016680:Genome, Bacterial; D044404:Genomic Islands / Q000235:genetics*; D044923:Helicobacter hepaticus / Q000235:genetics* / Q000472:pathogenicity*; D006505:Hepatitis / Q000382:microbiology* / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains