Recent advances in the synthesis of C-oligosaccharides.
This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, C-oligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.
Yuan
Xuejun
X
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Linhardt
Robert J
RJ
D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D007454:Iodides / Q000737:chemistry; D009844:Oligosaccharides / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D012493:Samarium / Q000737:chemistry
D000838:Anions; D002412:Cations; D005609:Free Radicals; D007454:Iodides; D009844:Oligosaccharides; D012493:Samarium; C409809:samarium diiodide