New insights into biliverdin reductase functions: linking heme metabolism to cell signaling.
Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways (25, 29, 51); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation (1, 25); and a reductase that catalyzes the conversion of biliverdin to bilirubin (27). These, together with the protein's primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades.
Maines
Mahin D
MD
Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York, USA. mahin_maines@urmc.rochester.edu
D000595:Amino Acid Sequence; D000818:Animals; D002468:Cell Physiological Phenomena; D006418:Heme / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D006418:Heme; D044925:Oxidoreductases Acting on CH-CH Group Donors; C019789:biliverdin reductase