title: A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.
abstract: Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.
authors.affiliation: Department of Clinical Sciences, Cornell University School of Veterinary Medicine, Ithaca, New York 14850, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Barr
authors.forename: K L
authors.initials: KL
authors.lastname: Warner
authors.forename: B G
authors.initials: BG
authors.lastname: Kornreic
authors.forename: J
authors.initials: J
authors.lastname: Piscitelli
authors.forename: A
authors.initials: A
authors.lastname: Wolfe
authors.forename: L
authors.initials: L
authors.lastname: Benet
authors.forename: J H
authors.initials: JH
authors.lastname: McKerrow
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000150:complications* / Q000188:drug therapy; D003546:Cysteine Endopeptidases / Q000187:drug effects*; D015853:Cysteine Proteinase Inhibitors / Q000627:therapeutic use*; D004285:Dogs; D006323:Heart Arrest / Q000209:etiology / Q000517:prevention & control*; D015800:Protozoan Proteins / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D015853:Cysteine Proteinase Inhibitors; D015800:Protozoan Proteins; D003546:Cysteine Endopeptidases; C074032:cruzain, Trypanosoma cruzi