title: Pathophysiologic aspects of major depression following traumatic brain injury.
abstract: Mood disorders, particularly major depression, are the most frequent complication of traumatic brain injury. Major depression is present in about 40% of patients hospitalization for a traumatic brain injury. Anxiety disorders, substance abuse, dysregulation of emotional expression, and aggressive outbursts are frequently associated with major depression, and their coexistence constitutes a marker of a more disabling clinical course. The complex interactions of genetic, developmental, and psychosocial factors determine patients' vulnerability to developing affective disturbances following a traumatic brain injury. Symptoms of depression cluster into the domains of low mood and distorted self-attitude, lack of motivation and anhedonia, subjective cognitive complaints, and hyperactive and disinhibited behavior. It is reasonable to assume that these symptomatic clusters have specific underlying mechanisms that need to be integrated in a comprehensive pathophysiologic model.
authors.affiliation: Department of Psychiatry, University of Iowa, Iowa City, USA. ricardo-jorge@uiowa.edu
authors.forename: Ricardo E
authors.initials: RE
authors.lastname: Jorge
authors.forename: Sergio E
authors.initials: SE
authors.lastname: Starkstein
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000453:epidemiology / Q000209:etiology / Q000534:rehabilitation; D001521:Behavior Therapy / Q000379:methods; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis* / Q000534:rehabilitation; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000209:etiology* / Q000534:rehabilitation; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D015994:Incidence; D015601:Injury Severity Score; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000209:etiology / Q000534:rehabilitation; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents