title: Dipeptidyl peptidase IV activity and/or structure homologs: contributing factors in the pathogenesis of rheumatoid arthritis?
abstract: Several of the proinflammatory peptides involved in rheumatoid arthritis pathogenesis, including peptides induced downstream of tumor necrosis factor-alpha as well as the monocyte/T cell-attracting chemokines RANTES and stromal cell-derived factor (SDF)-1alpha and the neuropeptides vasoactive intestinal peptide (VIP) and substance P, have their biological half-lives controlled by dipeptidyl peptidase IV (DPPIV). Proteolysis by DPPIV regulates not only the half-life but also receptor preference and downstream signaling. In this article, we examine the role of DPPIV homologs, including CD26, the canonical DPPIV, and their substrates in the pathogenesis of rheumatoid arthritis. The differing specific activities of the DPPIV family members and their differential inhibitor response provide new insights into therapeutic design.
authors.affiliation: Laboratory of Cancer Cell Biology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. Aleksi@mbox.cesnet.cz
authors.forename: Aleksi
authors.initials: A
authors.lastname: Sedo
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Duke-Cohan
authors.forename: Eva
authors.initials: E
authors.lastname: Balaziova
authors.forename: Liliana R
authors.initials: LR
authors.lastname: Sedova
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000201:enzymology* / Q000209:etiology* / Q000473:pathology; D020134:Catalytic Domain; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes; D051379:Mice; D010455:Peptides / Q000378:metabolism*; D011480:Protease Inhibitors
chemical_list: D007527:Isoenzymes; D010455:Peptides; D011480:Protease Inhibitors; D018819:Dipeptidyl Peptidase 4