Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs.
The condensation of the C-10 methoxybipyrrole precursor (3) of prodigiosin with indoles and a related pyrrole derivative yields novel analogs of prodigiosin. Biological evaluation of these products revealed compounds that inhibit cancer cell proliferation from 50 nM to 50 microM.
Baldino
Carmen M
CM
ArQule Inc. 19 Presidential Way, Woburn, MA 01801-5140, USA. carmen.baldino@bioduro.com
Parr
Jonathan
J
Wilson
Christopher J
CJ
Ng
Shi-Chung
SC
Yohannes
Daniel
D
Wasserman
Harry H
HH
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry; D015394:Molecular Structure; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D011353:Prodigiosin