title: Synthesis, reaction, and recycle of fluorous palladium catalysts for an asymmetric allylic alkylation without using fluorous solvents.
abstract: [Chemical reaction: See text] Chiral fluorous aminophosphine 4c bearing two fluorous ponytails was prepared from (S)-prolinol and applied to palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (7) with a dialkyl malonate-BSA-LiOAc system with high enantioselectivities (up to 97% ee). Results indicated that the chiral fluorous palladium catalyst from ligand 4c was easily separated from the reaction mixture by simple solid/liquid separation and could be reused up to five times.
authors.affiliation: Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. tmino@faculty.chiba-u.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Mino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sato
authors.forename: Akio
authors.initials: A
authors.lastname: Saito
authors.forename: Youichi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Saotome
authors.forename: Masami
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujita