title: Organo hydrogel hybrids. Formation of reservoirs for protein delivery.
abstract: A biodegradable organo hydrogel hybrid material is presented, which is formed through the water uptake of a phosphoryl choline zwitterionomer (PC ionomer). The water uptake and subsequent swelling is induced by the phosphoryl choline (PC) end group functionality. The nonfunctional poly(trimethylene carbonate) is hydrophobic and as such does not absorb any water. Disks of the PC ionomer showed significant water uptake, typically above 90 wt % when fully swollen. This high water uptake triggered us to utilize the material for drug and protein loading and subsequent release. Fluorescein and fluorescein-labeled proteins were used as simple models for the loading and release characteristics of the material which was studied by fluorescence spectroscopy. The rate of release of the loaded molecules was compared, and it was shown that the release rate was similar for FITC and insulin but slightly slower for albumin. These results suggest that the PC ionomer may be used as a biodegradable and low elastic modulus material with an additional drug and/or protein release capacity. Such materials are of particular interest for use in a variety of applications in vivo, for example as drug eluting stents.
authors.affiliation: Department of Materials Chemistry, Polymer Chemistry, Box 538, Uppsala University, SE-751 21 Uppsala, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Nederberg
authors.forename: Junji
authors.initials: J
authors.lastname: Watanabe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
authors.forename: Tim
authors.initials: T
authors.lastname: Bowden
mesh_terms: D000418:Albumins / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002138:Calibration; D002417:Cattle; D004146:Dioxanes / Q000737:chemistry; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000494:pharmacology; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010767:Phosphorylcholine / Q000737:chemistry; D011092:Polyethylene Glycols; D011108:Polymers / Q000737:chemistry; D011312:Pressure; D011506:Proteins / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012995:Solubility; D013050:Spectrometry, Fluorescence; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D000418:Albumins; D001672:Biocompatible Materials; D004146:Dioxanes; D005456:Fluorescent Dyes; D020100:Hydrogels; D046911:Macromolecular Substances; D011108:Polymers; D011506:Proteins; D014867:Water; D010767:Phosphorylcholine; D012710:Serum Albumin, Bovine; C059299:polytrimethylene carbonate; D011092:Polyethylene Glycols