Therapeutic response of rosacea to dobesilate.
Despite an incomplete understanding of the pathogenesis of rosacea, therapeutic modalities continue to expand. The principal subtype of rosacea includes erythematotelangiestatic rosacea, which is characterized by uncontrolled angiogenesis. Angiogenic growth factors such as fibroblast growth factors (FGF) and vascular endothelial growth factor (VEGF) are currently targets of intense effort to inhibit deregulated blood vessel formation in diseases such as cancer. Here we report a 33-years-old woman with erythematotelangestatic rosacea who responds to a daily treatment of topically applied dobesilate, an inhibitor of FGF, with an improvement in erythema and telangectasia after two weeks. Thus, dobesilate might be useful in the treatment of rosacea and other diseases that depend on pathologic angiogenesis.
Cuevas
Pedro
P
Department of Research, Hospital Ramón y Cajal, Madrid, Spain. pedro.cuevas@hrc.es
Arrazola
J M
JM
D000287:Administration, Topical; D000328:Adult; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D002123:Calcium Dobesilate / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005346:Fibroblast Growth Factors / Q000037:antagonists & inhibitors; D006801:Humans; D009824:Ointments; D012393:Rosacea / Q000188:drug therapy* / Q000473:pathology
D020533:Angiogenesis Inhibitors; D009824:Ointments; D002123:Calcium Dobesilate; D005346:Fibroblast Growth Factors