Understanding treatments for gout.
Gout is one of the most readily manageable of the rheumatic diseases. This article reviews basic pathways in purine metabolism, uric acid handling, and the pathogenic mechanism of clinical gout, as well as the areas in those pathways amenable to intervention. Attention is also given to associated comorbidities, such as hyperuricemia and obesity, hypertension, hyperinsulinemia, and coronary artery disease. The significance of lifestyle modifications, such as weight loss and alcohol reduction, is discussed as an important adjunct to pharmacotherapy in gout. Current and investigational agents used in gout management are also reviewed. Finally, treatment recommendations for acute and chronic gout are suggested.
Cannella
Amy C
AC
Mikuls
Ted R
TR
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001521:Behavior Therapy; D002908:Chronic Disease; D003078:Colchicine / Q000627:therapeutic use; D005260:Female; D006073:Gout / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D006074:Gout Suppressants / Q000627:therapeutic use; D015438:Health Behavior; D006801:Humans; D033461:Hyperuricemia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D017410:Practice Guidelines as Topic; D011687:Purines / Q000378:metabolism; D012307:Risk Factors; D014527:Uric Acid / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D006074:Gout Suppressants; D011687:Purines; D014527:Uric Acid; D003078:Colchicine