[Electrophoretic mobility and energy charge of the adenyl system of blood lymphocytes in guinea pigs immunized against plague with strain Yersinia pestis ev subcultures with different immunogenicity].
The injection of highly immunogenic vaccine strain Yersinia pestis EV, line NIIEG, into guinea pigs was accompanied, as early as 24 hours after this injection, by a drop in the electrophoretic mobility of the main amount of lymphocytes, significant shifts in the content and quantitative relation of adenine nucleotides in the mixed lymphocyte population, as well as T and B lymphocytes after their preparative electrophoretic sorting. The immunizatiom of guinea pigs with strain EV of the Japanese line, possessing faint immunogenic properties, produced few changes in the electrophoretic mobility of lymphocytes; no significant changes in the energy charge of the adenylate system of lymphocytes and their subpopulations in comparison with intact animals were established. The study of the metabolic processes in lymphocytes and their populations makes it possible to give more precise characterization to evaluate the prospects of various vaccine preparations.
Anisimova
T I
TI
Saiapina
L V
LV
Korsukov
V N
VN
D000227:Adenine Nucleotides / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D004586:Electrophoresis; D004735:Energy Transfer; D006168:Guinea Pigs; D007114:Immunization; D008214:Lymphocytes / Q000378:metabolism*; D010930:Plague / Q000276:immunology* / Q000517:prevention & control; D010931:Plague Vaccine / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism; D015010:Yersinia pestis / Q000737:chemistry / Q000276:immunology*
D000227:Adenine Nucleotides; D010931:Plague Vaccine