Molecular mechanisms regulating expression and function of transcription regulator inhibitor of differentiation 3.
The transcription factor antagonist inhibitor of differentiation 3 (Id3) has been implicated in many diverse developmental, physiological and pathophysiological processes. Its expression and function is subjected to many levels of complex regulation. This review summarizes the current understanding of these mechanisms and describes how they might be related to the diverse functions that have been attributed to the Id3 protein. Detailed understanding of these mechanisms should provide insights towards the development of therapeutic approaches to various diseases, including cancer and atherogenesis.
Lim
Robert Wai-Sui
RW
Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri 65212, USA. limr@health.missouri.edu
Wu
Jin-Mei
JM
D017398:Alternative Splicing; D000818:Animals; D002478:Cells, Cultured; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051796:Inhibitor of Differentiation Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D020033:Protein Isoforms / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives* / Q000494:pharmacology; D014157:Transcription Factors / Q000494:pharmacology*
D051796:Inhibitor of Differentiation Proteins; D009363:Neoplasm Proteins; D020033:Protein Isoforms; D012333:RNA, Messenger; D014157:Transcription Factors; C075640:ID3 protein, human; C016658:phorbolol myristate acetate; D013755:Tetradecanoylphorbol Acetate