title: Dydrogesterone in threatened abortion: pregnancy outcome.
abstract: OBJECTIVE
  To determine whether therapy with dydrogesterone in threatened abortion during the first trimester of pregnancy will improve pregnancy outcome.
  
  
  METHODS
  Prospective open study.
  
  
  METHODS
  Pregnant women presenting to the obstetric and gynaecology clinic admitting center with vaginal bleeding before 13 weeks gestation were evaluated for entry into the study. Women were excluded if they had a history of recurrent miscarriage.
  
  
  METHODS
  Eligible subjects were randomized to receive either dydrogesterone 40 mg stat dose followed by 10 mg twice a day for one week or conservative therapy.
  
  
  RESULTS
  One hundred and 54 women were recruited. There was no statistically significant differences between the two groups with regard to pre-treatment status. The continuing pregnancy success rate was significantly (p=0.037) higher in women treated with dydrogesterone (95.9%) compared with women who received conservative treatment (86.3%). The odds ratio of the success rate between dydrogesterone treatment and non-treatment was 3.773 (95% confidence interval: 1.009-14.108).
  
  
  CONCLUSIONS
  Corpus luteal support with dydrogesterone has been shown to reduce the incidence of pregnancy loss in threatened abortion during the first trimester in women without a history of recurrent abortion.
authors.affiliation: Department of Obstetrics and Gynaecology, University Kebangsaan, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. mhashim@mail.hukm.ukm.my
authors.forename: M H
authors.initials: MH
authors.lastname: Omar
authors.forename: M K
authors.initials: MK
authors.lastname: Mashita
authors.forename: P S
authors.initials: PS
authors.lastname: Lim
authors.forename: M A
authors.initials: MA
authors.lastname: Jamil
mesh_terms: D000033:Abortion, Threatened / Q000188:drug therapy / Q000517:prevention & control*; D000328:Adult; D004394:Dydrogesterone / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D016032:Randomized Controlled Trials as Topic
chemical_list: D004394:Dydrogesterone