title: Assessing the in vitro effectiveness of antimicrobials against Mycoplasma mycoides subsp. mycoides small-colony type to reduce contagious bovine pleuropneumonia infection.
abstract: In vitro minimum inhibitory concentrations were determined for 21 antimicrobials against 41 isolates of Mycoplasma mycoides subsp. mycoides small-colony type, the cause of contagious bovine pleuropneumonia. Of the antimicrobials used most widely in Africa, oxytetracycline and tilmicosin were effective, while the isolates were resistant to tylosin. These results provide a baseline for monitoring antimicrobial resistance.
authors.affiliation: Veterinary Laboratories Agency (Weybridge), Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom. r.d.ayling@vla.defra.gsi.gov.uk
authors.forename: R D
authors.initials: RD
authors.lastname: Ayling
authors.forename: S
authors.initials: S
authors.lastname: Bisgaard-Frantzen
authors.forename: J B
authors.initials: JB
authors.lastname: March
authors.forename: K
authors.initials: K
authors.lastname: Godinho
authors.forename: R A J
authors.initials: RA
authors.lastname: Nicholas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D018942:Macrolides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009176:Mycoplasma mycoides / Q000187:drug effects*; D010118:Oxytetracycline / Q000494:pharmacology; D011002:Pleuropneumonia, Contagious / Q000188:drug therapy*; D015645:Tylosin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D010118:Oxytetracycline; C052319:tilmicosin; D015645:Tylosin