title: Human immunodeficiency virus type 1 latency model for high-throughput screening.
abstract: Human immunodeficiency virus type 1 (HIV-1) is not eliminated from patients even after years of antiretroviral therapy, apparently due to the presence of latently infected cells. Here we describe the development of a cell-based system of latency that can be used for high-throughput screening aimed at novel drug discovery to eradicate HIV-1 infection.
authors.affiliation: Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA.
authors.forename: Sofiya
authors.initials: S
authors.lastname: Micheva-Viteva
authors.forename: Annmarie L
authors.initials: AL
authors.lastname: Pacchia
authors.forename: Yacov
authors.initials: Y
authors.lastname: Ron
authors.forename: Stuart W
authors.initials: SW
authors.lastname: Peltz
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Dougherty
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000503:physiopathology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D017735:Virus Latency / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents