Effect of biotin on DNA and histone phosphorylation in the rat liver.
The results offer further evidence for biotin activity in the phosphorylation mechanism. The decreased 32p incorporation into DNA and histones found in the biotin deficient rat liver is indicative of the importance of the vitamin in the DNA and histones synthesis and in the interactions between histone proteins and DNA, and consequently on the RNA and proteins synthesis.
Petrelli
F
F
Institute of General Physiology, University of Camerino, Italy.
Coderoni
S
S
Moretti
P
P
Paparelli
M
M
D000818:Animals; D001710:Biotin / Q000172:deficiency*; D004247:DNA / Q000378:metabolism*; D005260:Female; D006657:Histones / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D006657:Histones; D001710:Biotin; D004247:DNA