title: Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea.
abstract: BACKGROUND
  Autosomal dominant chronic mucocutaneous candidiasis (CMC) without endocrinopathy (OMIM 114580) is a well-described entity. The associations recorded with this disorder to date are intercellular adhesion molecule-1 (ICAM-1) deficiency and hyper-immunoglobulin E syndrome.
  
  
  METHODS
  We report a new association in a family (mother and nonidentical twin sons) where acne rosacea is a prominent feature together with CMC. In addition, antibodies to thyroid microsomal and antiparietal cell were also isolated. The autoantibodies might be associated with a current "latent" endocrinopathy in particular autoimmune thyroiditis.
  
  
  METHODS
  The patient was treated with intermittent pulses of itraconazole for the candidiasis and doxycycline initially before being substituted with isotretinoin 6 months later for the rosacea.
  
  
  RESULTS
  The patient's candidiasis responded well and has been in remission for 3 months while his rosacea continues to improve.
authors.affiliation: National Skin Centre, Singapore. melvinee@nsc.gov.sg
authors.forename: H L
authors.initials: HL
authors.lastname: Ee
authors.forename: H H
authors.initials: HH
authors.lastname: Tan
authors.forename: S K
authors.initials: SK
authors.lastname: Ng
mesh_terms: D000328:Adult; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D012393:Rosacea / Q000150:complications*