[Effect of allopurinol on rat testicles morphology, submitted to ischaemia for spermatic cord torsion followed by reperfusion].
OBJECTIVE
In this investigation has been studied the effect of the allopurinol on the reperfusion injury phenomenon in testicles of rats.


METHODS
Eighty adults Wistar rats were divided in 4 groups: sham without allopurinol, sham with allopurinol, right testicular torsion for one hour without allopurinol and right testicular torsion for one hour with allopurinol. Bilateral orchiectomy was performed 60 days of the experiment and the testis were processed for optical microscopy, and examined to asses the seminiferous ducts and the spermatogenic cells.


RESULTS
There was significant atrophy and histological damage of the right testis.


CONCLUSIONS
Allopurinol did not protected the testis against the effects of the reperfusion injury.
Silva
Andréia C M Brochado Antoniolli
AC
Universidade Federal de São Paulo, Escola Paulista de Medicina. abrochado@hotmail.com
Ortiz
Valdemar
V
Silva
Roberto Antoniolli da
RA
Tognini
João Ricardo
JR
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*; D013086:Spermatic Cord Torsion / Q000473:pathology* / Q000628:therapy; D013733:Testicular Diseases / Q000517:prevention & control; D013737:Testis / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology
D016166:Free Radical Scavengers; D000493:Allopurinol