title: Protective effect of red wine on oxidative stress and antioxidant enzyme activities in the brain and kidney induced by feeding high cholesterol in rats.
abstract: The effect of red wine (400 ml/70 kg) on brain and kidney oxidative stress and antioxidative enzymes activities induced by cholesterol-enriched diet (supplemented with 1.65% of cholesterol (w/w) for 4 weeks) was studied in rats. When red wine (Montilla-Moriles, Cordoba, Spain) was simultaneously supplemented to high-cholesterol diet for 4 weeks, total cholesterol and lipid peroxidation products in the brain, kidney and erythrocytes significantly decreased compared with the high-cholesterol, while GSH content and antioxidative enzymes activities enhanced. On the other hand, the urinary excretion of urea, creatinine and albumin decreased significantly. These results suggest that red wine may have a neuro-nephroprotective effect against oxidative stress and hypercholesterolemia.
authors.affiliation: Facultad de Medicina, Departamento de Bioquimica y Biologia Molecular, Universidad de Cordoba, Avda. Menendez Pidal s/n, 14004 Cordoba, Spain. bb1molop@uco.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Montilla
authors.forename: Isabel
authors.initials: I
authors.lastname: Espejo
authors.forename: Maria C
authors.initials: MC
authors.lastname: Muñoz
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Bujalance
authors.forename: Juan R
authors.initials: JR
authors.lastname: Muñoz-Castañeda
authors.forename: Isaac
authors.initials: I
authors.lastname: Tunez
mesh_terms: D000818:Animals; D000975:Antioxidants; D001921:Brain / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006937:Hypercholesterolemia / Q000378:metabolism; D007668:Kidney / Q000201:enzymology*; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014920:Wine
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase