title: Black foam films from aqueous solutions of a mixture of phospholipids and a permeation enhancer.
abstract: The influence of a permeation enhancer on the properties of phospholipid black foam films has been studied through the combination of three complementary techniques: surface tension measurements, X-ray reflectivity, and the "diminishing bubble" method. This permeation enhancer is said to optimize the delivery of active ingredients into or through the stratum corneum: the 4-decyl oxazolidin-2-one. We made films of a complex phospholipid mixture that mimic the behavior of the enhancer in a membrane cell. Mixed phospholipids/4-decyl oxazolidin-2-one/NaCl solutions were studied with various 4-decyl oxazolidin-2-one concentrations. Stable black films were obtained and their thicknesses examined. The evolution of the coefficient of gas permeability with 4-decyl oxazolidin-2-one concentration is also addressed.
authors.affiliation: LVMH R&D, Avenue de Verdun, Saint Jean de Braye Cedex F-45804, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Tranchant
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bonté
authors.forename: Sébastien
authors.initials: S
authors.lastname: Leroy
authors.forename: Mickael
authors.initials: M
authors.lastname: Nedyalkov
authors.forename: Dimo
authors.initials: D
authors.lastname: Platikanov
authors.forename: Isabelle
authors.initials: I
authors.lastname: Javierre
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Benattar