[Specific features of diagnosis of hormonal insufficiency in patients with tumors of the adrenal cortex].
An examination of 145 patients with incidentalomas and 195 women with virale syndrome has shown that 20% of patients with incidentalomas and 23.1% of patients with steroidogenesis have disorders of the adrenal steroidogenesis characteristic of the obliterated form of congenital hyperplasia of the adrenal cortex (CHAC) with a defect of 11beta-hydroxylase on the basis of the following biochemical criteria: the elevation in blood of the basal levels of 11-desoxycortisole and 11beta-desoxycorticosterone, decreased excretion of free cortisole with urine, lower indices of hydrocortisole/cortisone in blood and free cortisole/free cortisone in urine, in the test with corticotropin - elevation in blood of the level of 11-desoxycortisole and 11-desoxycorticosterone, decreased relationships cortisole/11-desoxycortisole and cortisole/cortisone and lower growth of the levels of corticosterone and cortisole. The data obtained suggest that long-standing obliterated form of CHAC with a defect of 11beta-hydroxylase might be the cause of the formation of certain incidentalomas.
Velikanova
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D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D003350:Cortodoxone / Q000097:blood*; D003900:Desoxycorticosterone / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D015415:Biomarkers; D003900:Desoxycorticosterone; D003350:Cortodoxone; D006854:Hydrocortisone