Photoswitched cell adhesion on surfaces with RGD peptides.
Coating of surfaces by RGD peptides is well-known. Herein we describe the possibility to switch cell adhesion properties by changing the distance and orientation of the RGD peptides to the surface. A set of RGD peptides of the type cyclo(-RGDfK-) was synthesized containing the photoswitchable 4-[(4-aminophenyl)azo]benzocarbonyl central unit as spacer between the acrylamide anchor and the RGD peptide. PMMA (poly methyl methacrylate) surfaces were coated with these peptides. Control of adhesion stimulation by irradiation with 366 or 450 nm light could be achieved.
Auernheimer
Jörg
J
Department Chemie, Lehrstuhl II für Organische Chemie, Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany.
Dahmen
Claudia
C
Hersel
Ulrich
U
Bausch
Andreas
A
Kessler
Horst
H
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D051379:Mice; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D010777:Photochemistry; D013057:Spectrum Analysis
D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid