title: Experimental reproduction of proliferative enteropathy and the role of IFN-gamma in protective immunity against Lawsonia intracellularis in mice.
abstract: Proliferative enteropathy was reproduced in IFN-gamma receptor knockout (IFN-gamma R-) mice by experimental infection with Lawsonia intracellularis (L. intracellularis). The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However, high levels of IFN-gamma were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-gamma produced in the infected mice should have been utilized by it's receptor to elicit protective immune responses against L. intracellularis infections.
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Yun-Young
authors.initials: YY
authors.lastname: Go
authors.forename: Jeong-Keun
authors.initials: JK
authors.lastname: Lee
authors.forename: Jeong-Yong
authors.initials: JY
authors.lastname: Ye
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Park
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
authors.forename: Soo-Ki
authors.initials: SK
authors.lastname: Kim
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
mesh_terms: D000818:Animals; D004279:DNA, Viral; D045824:Desulfovibrionaceae Infections / Q000276:immunology* / Q000382:microbiology; D007371:Interferon-gamma / Q000276:immunology*; D007410:Intestinal Diseases / Q000276:immunology* / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology; D020639:Lawsonia Bacteria / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D018345:Mice, Knockout; D016133:Polymerase Chain Reaction; D017471:Receptors, Interferon / Q000502:physiology; D000096743:Interferon gamma Receptor
chemical_list: D004279:DNA, Viral; D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor