title: Discovery of a potent phenolic N1-benzylidene-pyridinecarboxamidrazone selective against Gram-positive bacteria.
abstract: As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria.
authors.affiliation: School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK. D.L.Rathbone@aston.ac.uk
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Rathbone
authors.forename: Katy J
authors.initials: KJ
authors.lastname: Parker
authors.forename: Michael D
authors.initials: MD
authors.lastname: Coleman
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lambert
authors.forename: David C
authors.initials: DC
authors.lastname: Billington
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011725:Pyridines