title: [Prospective study of first unprovoked seizure].
abstract: We prospectively examined the natural history of children who suffered a first unprovoked seizure (FUS). Forty-five children who suffered a seizure without any detectable precipitating factors were enrolled in this study. Absence seizure, myoclonic seizure, and epileptic spasms were excluded from this study. They were followed for at least 2 years without anti-epileptic medications in 43 cases (2 were given drugs). Thirty patients (66.7%) had another seizure during follow up. Of the 30 patients with recurrence, 11 suffered the second seizure within 1 month, 19 within 3 months, 24 within 6 months, 26 within 1 year, and 30 within 2 years. Occurrence of generalized convulsions, a past history and family history of febrile seizures, epileptic discharges on the EEG (especially a diffuse pattern), and developmental delay prior to the FUS were risk factors for seizure recurrence. Up to one third of the patients had no more recurrent seizures during the next 2 years, so it seems reasonable to follow FUS patients without medication.
authors.affiliation: Division of Pediatrics, Hirakata Municipal Hospital, Hirakata, Osaka. tanabemapa@pop01.odn.ne.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Tanabe
authors.forename: Keita
authors.initials: K
authors.lastname: Hara
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kashiwagi
authors.forename: Mototada
authors.initials: M
authors.lastname: Shichiri
authors.forename: Shuhei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Eiji
authors.initials: E
authors.lastname: Wakamiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamai
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D012640:Seizures / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000927:Anticonvulsants