Maximum likelihood estimation in survival studies under progressive interval censoring with random removals.
Censoring occurs commonly in clinical trials. This article investigates a new censoring scheme, namely, Type II progressive interval censoring with random removals to cope with the setting that patients are examined at fixed regular intervals and dropouts may occur during the study period. We discuss the maximum likelihood estimation of the model parameters and derive the corresponding asymptotic variances when survival times are assumed to be Weibull distributed. An example is discussed to illustrate the application of the results under this censoring scheme.
Xiang
Liming
L
Department of Management Sciences, City University of Hong Kong, Kowloon, Hong Kong.
Tse
Siu Keung
SK
D003627:Data Interpretation, Statistical; D016013:Likelihood Functions; D015233:Models, Statistical; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D016008:Statistical Distributions; D016019:Survival Analysis