title: [Protective effects of yanggan lidan granules on carbon tetrachloride-induced liver damage in mice].
abstract: OBJECTIVE
  To observe the protective effects of Yanggan Lidan Granules (YGLDG) on carbon tetrachloride (CCl(4))-induced liver damage in mice and to find out its mechanism.
  
  
  METHODS
  A model of chronic liver damage was established in mice by intraperitoneal injection of CCl(4). After three weeks, those model mice were treated with low-, medium-, high-dose YGLDG, Danning Tablets and bifendate respectively for four weeks. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected.
  
  
  RESULTS
  YGLDG could significantly reduce the levels of serum ALT and AST in model mice, and the content of MDA was obviously decreased while the content of SOD was increased in liver tissue.
  
  
  CONCLUSIONS
  The therapeutic effect of YGLDG on mice with CCl(4)-induced liver damage is to relieve the seriousness of liver damage, and its mechanism may relate to reducing peroxidation activity in liver tissue.
authors.affiliation: Center of Scientific Research, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
authors.forename: Sheng-Fu
authors.initials: SF
authors.lastname: You
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Zheng
authors.forename: Guang
authors.initials: G
authors.lastname: Ji
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Wei
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Pei-Ting
authors.initials: PT
authors.lastname: Zhu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D008517:Phytotherapy; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase