An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor.
Activation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper type 2 (T(H)2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates much of the existing data that ST2 promotes T(H)2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases.
Dinarello
Charles A
CA
University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
D000818:Animals; D020170:Caspase 1 / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000145:classification* / Q000276:immunology / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
D007375:Interleukin-1; D011956:Receptors, Cell Surface; D020170:Caspase 1