title: [A study of some genes related to serotoninergic and dopaminergic systems and auditory evoked-potentials (P300) in patients with schizophrenia and spectrum disorders and their first-degree relatives].
abstract: The changes of P300 parameters (lower amplitude and increased latency) are thought to be the most prominent phenomena of schizophrenia. A role of gene polymorphism in P300 generation was supported by several associative studies in psychiatrically well subjects and patients with mental disorders. We studied P300 parameters and the following polymorphisms: T102C for the serotonin receptor type 2A (5-HTR2A) gene, the 5-HTTLPR for the serotonin transporter gene, -809G/A, -616G/C N -52C/T SNPs in the promoter region of the dopamine D4 receptor (DRD4) gene and the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) in 74 patients with schizophrenia and spectrum disorders and 71 their first-degree relatives. No association was found between serotonergic system genes and P300. The -809G/A DRD4 gene polymorphism was related to amplitude in all frontal leads (p=0,01) in patients. In relatives, an association was observed between -521C/T DRD4 variants and latency (p=0,005) as well as between the COMT gene polymorphism and P300 amplitude (p=0,004) at the central lead. Thus, the genes involved in dopaminergic system play a role in P300 generation both in patients with schizophrenia and spectrum disorders and their relatives.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.forename: I S
authors.initials: IS
authors.lastname: Lebedeva
authors.forename: I K
authors.initials: IK
authors.lastname: Gritsenko
authors.forename: G I
authors.initials: GI
authors.lastname: Korovaĭtseva
authors.forename: M V
authors.initials: MV
authors.lastname: Alfimova
authors.forename: T V
authors.initials: TV
authors.lastname: Lezheĭko
authors.forename: L I
authors.initials: LI
authors.lastname: Abramova
authors.forename: V G
authors.initials: VG
authors.lastname: Kaleda
authors.forename: R P
authors.initials: RP
authors.lastname: Ebshteĭn
authors.forename: E I
authors.initials: EI
authors.lastname: Rogaev
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D017931:DNA Primers; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D017931:DNA Primers; D005819:Genetic Markers; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D050638:Receptors, Dopamine D4; D002394:Catechol O-Methyltransferase