title: The participation of cognitively impaired elderly in research.
abstract: It is critical that cognitively impaired adults be permitted to participate in research in order to develop a greater understanding of the underlying causes of the impairments and strategies to prevent or ameliorate their impact. Significant ethical and legal issues may arise in the recruitment and enrollment of these persons as study participants, due to difficulties in understanding information, uncertainty regarding the existence of sufficient mental capacity to provide informed consent to participate, and the potential for coercion to participate as a function of limited capacity and dependence on others for care. This article explores these issues and suggests mechanisms to maximize the understanding of information and facilitate the cognitively impaired elders' expression of choice during incapacity.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4945, USA. Sana.Loue@cwru.edu
authors.forename: Sana
authors.initials: S
authors.lastname: Loue
mesh_terms: D016223:Advance Directives; D000368:Aged; D000369:Aged, 80 and over; D035843:Biomedical Research; D005260:Female; D006801:Humans; D008297:Male; D016743:Mental Competency; D010358:Patient Participation / Q000331:legislation & jurisprudence / Q000523:psychology*; D018579:Patient Selection / Q000941:ethics; D014481:United States