Distribution of (3)H-dopamine and (3)H-DAGO binding sites in the central part of rat sinoatrial node.
Distribution of (3)H-dopamine and (3)H-DAGO binding sites was studied by autoradiography on semithin sections of total preparations of rat sinoatrial node. The relative density of (3)H-dopamine and (3)H-DAGO binding sites in the functional nucleus of the sinoatrial node was minimum and increased in the cranial and caudal directions. The level of (3)H-dopamine binding in the perinodal atrial myocardium was appreciably lower (22+/-6%), while binding of (3)H-DAGO was similar (76+/-16%) to that in the periarterial zone of the sinoatrial node.
Sutyagin
P V
PV
Department of Morphology, Russian State Medical University, Moscow.
Kalinina
E E
EE
Pylaev
A S
AS
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001345:Autoradiography; D001665:Binding Sites; D004298:Dopamine / Q000096:biosynthesis*; D004566:Electrodes; D004594:Electrophysiology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000737:chemistry*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012849:Sinoatrial Node / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004298:Dopamine