title: Rapid-onset primary biliary cirrhosis resembling drug-induced liver injury.
abstract: A 54-year-old woman was admitted to our hospital because of acute liver injury. Since she had a history of having used a diet product, drug-induced liver injury (DILI) was initially considered. However, the patient was subsequently diagnosed as suffering from primary biliary cirrhosis (PBC) based on the findings of liver histology and serum anti-mitochondrial antibody positivity. Overlap syndrome between PBC and autoimmune hepatitis (AIH) was also suspected, however, serum levels of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase became normal three months later, after treatment with combination therapy comprising ursodeoxycholic acid plus bezafibrate. We therefore concluded that the liver disease in this patient was actually PBC, but that it resembled overlap syndrome or DILI. In cases of PBC, a rapid onset, as frequently seen in the case of DILI, viral hepatitis or AIH, is not common. We herein report a rare case of PBC which resembled DILI.
authors.affiliation: Third Department of Medicine, Fukuoka University School of Medicine.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sohda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiga
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Nakane
authors.forename: Shinya
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshikane
authors.forename: Akira
authors.initials: A
authors.lastname: Anan
authors.forename: Norihisa
authors.initials: N
authors.lastname: Suzuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Irie
authors.forename: Kaoru
authors.initials: K
authors.lastname: Iwata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Shotaro
authors.initials: S
authors.lastname: Sakisaka
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D003937:Diagnosis, Differential; D019587:Dietary Supplements / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis*; D008875:Middle Aged; D028321:Plant Preparations; D013997:Time Factors
chemical_list: D028321:Plant Preparations