Estimating the incidence of dementia: the impact of adjusting for subject attrition using health care utilization data.
OBJECTIVE
To estimate incidence rates for dementia and the impact of subject attrition on these rates.


METHODS
Crude, age- and gender-specific incidence rates of dementia and Alzheimer's disease were calculated using person-years analysis and Cox proportional hazard models in a population-based cohort study of 1952 adults aged 65+ years in Manitoba, Canada. Rates were standardized to the nondemented population using the direct method. Ratios of incidence rates comparing completers to subjects who had died, refused, or were unavailable for follow up were based on health care utilization data (available for all subject groups) and used to adjust rates for attrition.


RESULTS
Decedents had a significantly higher incidence of dementia than did subjects who completed the follow-up assessment. The incidence in subjects who refused or were unavailable at follow up was intermediate between decedents and completers. Adjusted for attrition, the standardized dementia incidence rate for community and institutional subjects was 25.3/1000 person-years, significantly higher than that based on follow-up assessments only (17.8/1000 person-years; 95% confidence interval: 14.3-21.4).


CONCLUSIONS
The impact of loss to follow up on incidence rates varies depending on the reason for subject attrition. Incidence studies of dementia should develop strategies to characterize and address subject attrition to avoid underestimating disease incidence.
Tyas
Suzanne L
SL
Graduate Center for Gerontology and Department of Epidemiology, University of Kentucky, Lexington, KY, USA. styas@uky.edu
Tate
Robert B
RB
Wooldrage
Kate
K
Manfreda
Jure
J
Strain
Laurel A
LA
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D006296:Health Services / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D012737:Sex Factors