title: Long-lived plasma cells in immunity and immunopathology.
abstract: Following tetanus vaccination, a wave of antibody-secreting cells appear in the peripheral blood composed of vaccine-specific, migratory plasmablasts and plasma cells secreting antibodies specific for other antigens. The latter probably were tissue resident plasma cells formed in earlier immune responses that are mobilized due to competition with the newly formed tetanus-specific plasmablasts. Newly formed plasma cells secreting antibodies specific for a particular antigen/vaccine are accommodated in the bone marrow likely at the global expense of the pre-existing long-lived plasma cell population providing humoral memory for other antigens. Plasmablasts but not mature plasma cells are attracted by the ligands for the chemokine receptors CXCR4 and CXCR3. While CXCR4 and its cognate ligand is important for plasma cell homing to the bone marrow, CXCR3 and its ligand IP10 are likely to be involved in attracting them to inflamed tissue. In NZB/W mice, a model for systemic lupus, long-lived autoreactive plasma cells are present not only in bone marrow, but also in inflamed tissues and spleen. Autoreactive plasma cells in the spleen are present long before the onset of the disease, suggesting that these cells contribute to induction of immunopathology.
authors.affiliation: German Arthritis Research Center Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Moser
authors.forename: Gwendolin
authors.initials: G
authors.lastname: Muehlinghaus
authors.forename: Rudi
authors.initials: R
authors.lastname: Manz
authors.forename: Henrik
authors.initials: H
authors.lastname: Mei
authors.forename: Caroline
authors.initials: C
authors.lastname: Voigt
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Thomas
authors.initials: T
authors.lastname: Dörner
authors.forename: Falk
authors.initials: F
authors.lastname: Hiepe
authors.forename: Andreas
authors.initials: A
authors.lastname: Radbruch
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000502:physiology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D010950:Plasma Cells / Q000276:immunology* / Q000378:metabolism; D019707:Receptors, Chemokine / Q000378:metabolism*
chemical_list: D019707:Receptors, Chemokine