Requirements for research investigations to clarify the relationships and management of menstrual abnormalities in women with hemostatic disorders.
This article highlights a comprehensive range of research investigations which are required to clarify the relationships between the symptom of excessively heavy menstrual bleeding and different disorders of systemic hemostasis and their management. The need for these investigations was stimulated by an international workshop involving hematologists and gynecologists with expertise and interests in these fields. The field was reviewed by a group of experts who systematically considered nomenclature, definitions, investigations, and management and identified areas of uncertainty, controversy, or absence of information. This article is an extension of those preliminary research discussions. Recommendations are made for a range of important research studies to define the nomenclature, definitions, mechanisms, clinical investigations and management of heavy menstrual bleeding in women with disorders of systemic hemostasis.
Fraser
Ian S
IS
Department of Obstetrics and Gynaecology, University of Sydney, Sydney, New South Wales, Australia. helena@med.usyd.edu.au
Bonnar
John
J
Peyvandi
Flora
F
D001778:Blood Coagulation Disorders / Q000628:therapy*; D002986:Clinical Trials as Topic / Q000379:methods*; D019468:Disease Management; D005260:Female; D006487:Hemostasis; D006801:Humans; D008595:Menorrhagia / Q000628:therapy*; D008598:Menstruation; D012107:Research Design