title: Timing of aortic valve replacement in elderly patients with symptomatic aortic valve disease using outpatient clinical parameters.
abstract: OBJECTIVE
  To determine by how far worsening outpatient clinical parameters can affect outcome after aortic valve replacement, in patients with preserved left ventricular function and symptomatic aortic valve disease.
  
  
  METHODS
  Five hundred patients with aortic valve disease underwent aortic valve replacement using a bioprosthesis. In 348 patients, another procedure was added. The preoperative outpatient parameters were investigated for their effect on hospital and long-term mortality. A Fisher exact, Kaplan-Meier univariate and Cox proportional hazard analysis were used.
  
  
  RESULTS
  A retrospective follow-up of 2022 patient years was obtained. Five preoperative parameters were found to be more present in patients with a decreased left ventricular function: 1) severity of symptoms, 2) previous myocardial infarction, 3) conduction defects, 4) aortic valve regurgitation and 5) increasing need for medication. In patients with an ejection fraction of 50% or more, logistic regression analysis showed that hospital mortality increased with need for medication (p=0.004), previously performed CABG (0.015), increase in symptoms (p=0.018) and myocardial infarction (p=0.034). A Kaplan-Meier analysis revealed aortic valve regurgitation (p=0.017) and increased need for medication (p=0.012) as significant on long-term survival. Presence of a previous myocardial infarction showed a trend (p=0.062). A Cox' proportional hazard analysis showed for global mortality increased need for medication (p=0.010) and previous myocardial infarction (p=0.018) as independent factors and for long-term mortality, this was aortic valve regurgitation (p=0.001).
  
  
  CONCLUSIONS
  Results after aortic valve replacement deteriorate with the presence of valve regurgitation, a preoperative myocardial infarction, increasing need for medication or severity of symptoms, even for an ejection fraction of 50% or more. Anamnesis with special care to the degree of symptoms and increasing need for medication early in the valve disease could lead to early referral, thereby reducing number of patients with severe symptoms and improving postoperative results.
authors.affiliation: Human Anatomy and Embryology, University of Antwerp, Belgium. wilhelm.mistiaen@ua.ac.be
authors.forename: W
authors.initials: W
authors.lastname: Mistiaen
authors.forename: P
authors.initials: P
authors.lastname: Van Cauwelaert
authors.forename: S U
authors.initials: SU
authors.lastname: Sys
authors.forename: P
authors.initials: P
authors.lastname: Muylaert
authors.forename: F
authors.initials: F
authors.lastname: Harrisson
authors.forename: H
authors.initials: H
authors.lastname: Bortier
mesh_terms: D000367:Age Factors; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D010045:Outpatients; D011300:Preoperative Care; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013318:Stroke Volume; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome