title: Creutzfeldt-Jakob disease acquired via a dural graft: failure of therapy with quinacrine and chlorpromazine.
abstract: BACKGROUND
  Accidental transmission of Creutzfeldt-Jakob disease (CJD) has been reported after neurosurgical interventions, use of intracerebral electrodes, corneal transplants, and after the administration of human-derived hormones. Acquired CJD has also been documented after dural grafting with tissues of human cadaver origin. At present, quinacrine and chlorpromazine are being investigated for the treatment of sporadic CJD, with the hope of offering an effective treatment of an otherwise fatal disease. Our objective was to report a case of iatrogenic CJD occurring 18 years after the implant of a dural graft of human origin and to inform on the results of the treatment with quinacrine and chlorpromazine.
  
  
  METHODS
  In 1984, a 46-year-old woman was given a Lyodura graft for decompression of Chiari I malformation and syringomyelia. The patient was diagnosed with CJD in 2002. In view of the scarce options for treatment of CJD and after reviewing the current literature, the patient was treated with quinacrine and chlorpromazine. She showed no clinical improvement and died 6 months after hospital admission. The iatrogenic origin of the disease in this patient is supported by the clinical features, laboratory data, and findings from the brain necropsy.
  
  
  CONCLUSIONS
  Patients who have received a dural graft of cadaveric origin may be at risk for developing CJD after very prolonged incubation periods. Treatment with quinacrine and chlorpromazine for acquired CJD was ineffective in our patient. A clinical trial on the use of antiprion agents is warranted.
authors.affiliation: Service of Neurosurgery, Virgen de la Arrixaca University Hospital, Murcia, Spain. juanf.martinezlage@cablemurcia.com
authors.forename: Juan F
authors.initials: JF
authors.lastname: Martínez-Lage
authors.forename: Alberto
authors.initials: A
authors.lastname: Rábano
authors.forename: Juan
authors.initials: J
authors.lastname: Bermejo
authors.forename: Miguel
authors.initials: M
authors.lastname: Martínez Pérez
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Guerrero
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Contreras
authors.forename: Alberto
authors.initials: A
authors.lastname: Lunar
mesh_terms: D000328:Adult; D001139:Arnold-Chiari Malformation / Q000601:surgery; D002102:Cadaver; D002746:Chlorpromazine / Q000627:therapeutic use*; D007562:Creutzfeldt-Jakob Syndrome / Q000188:drug therapy* / Q000209:etiology*; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D004351:Drug Resistance; D004388:Dura Mater / Q000601:surgery*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008875:Middle Aged; D011796:Quinacrine / Q000627:therapeutic use*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D018492:Dopamine Antagonists; D004791:Enzyme Inhibitors; D011796:Quinacrine; D002746:Chlorpromazine