Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on methicillin-resistant Staphylococcus aureus (MRSA) infection in mice.
Anti-bacterial activity of two synthesized oligopeptides, RLYLRIGRR-NH2 (peptide A) and RLRLRIGRR-NH2 (peptide B), both which based on a putative active site of defensin, an anti-bacterial peptide from the beetle Allomyrina dichotoma, was examined by macroscopic and histopathologic assessment during the course of infection in mice inoculated with methicillin-resistant Staphylococcus aureus (MRSA) in vivo. Both peptides A and B decreased the mortality of mice inoculated with MRSA. Peptides A and B decreased the macroscopical and histopathological lesions by MRSA infection in mice even seven days after the challenge. The anti-bacterial activity of peptides A and B has a therapeutic effect on MRSA infection in mice even seven days after being challenged.
Yamada
Manabu
M
National Institute of Animal Health, Tsukuba, Ibaraki, Japan.
Nakamura
Kikuyasu
K
Saido-Sakanaka
Hisako
H
Asaoka
Ai
A
Yamakawa
Minoru
M
Yamamoto
Yu
Y
Koyama
Yukari
Y
Hikosaka
Kenji
K
Shimizu
Akira
A
Hirota
Yoshikazu
Y
D000818:Animals; D001517:Coleoptera / Q000737:chemistry*; D004285:Dogs / Q000382:microbiology; D007668:Kidney / Q000473:pathology; D008297:Male; D016106:Methicillin Resistance / Q000502:physiology; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use*; D010413:Penis / Q000473:pathology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology
D009842:Oligopeptides