title: Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challenge.
abstract: We determined the protective effect of moxifloxacin, azithromycin, and amoxicillin against Streptococcus pneumoniae infection of respiratory cells. Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective.
authors.affiliation: Institute of Medical Microbiology and Hygiene, Universitätsklinikum Tübingen, Wilhelmstrasse 31, D-72074 Tübingen, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Ulrich
authors.forename: Cordula
authors.initials: C
authors.lastname: Albers
authors.forename: Jan-Georg
authors.initials: JG
authors.lastname: Möller
authors.forename: Axel
authors.initials: A
authors.lastname: Dalhoff
authors.forename: Gisela
authors.initials: G
authors.lastname: Korfmann
authors.forename: Frank
authors.initials: F
authors.lastname: Künkele
authors.forename: Gerd
authors.initials: G
authors.lastname: Döring
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects* / Q000382:microbiology; D024841:Fluoroquinolones; D006801:Humans; D000077266:Moxifloxacin; D011804:Quinolines / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000658:Amoxicillin; D017963:Azithromycin; D000077266:Moxifloxacin