title: Synthesis of chitosan microspheres containing pendant cyclodextrin moieties and their interaction with biological active molecules.
abstract: A new route to obtain chitosan derivatives containing cyclodextrin moieties as pendant groups was developed. The chitosan microspheres, obtained through crosslinking with glutaraldehyde of an acetic acid solution of chitosan, in an organic suspension medium, were reacted with chloroacyl cyclodextrins in organic basic solvents. The acyl cyclodextrin moieties are linked to the chitosan microspheres through C-N bonds, with the elimination of HCl; higher amounts of acyl cyclodextrin are linked to the microspheres with a smaller crosslinking degree. The chitosan-cyclodextrin conjugates retain higher amounts of bioactive substances (nalidixic acid, piroxicam) or of p-nitrophenol (model substance) than their parent chitosan supports, both by ionic forces and by the formation of inclusion complexes in the cyclodextrin inner cavities. After these preliminary studies, one can appreciate that the cyclodextrin-chitosan conjugates could be used as supports for chromatographic separations or controlled release drug systems.
authors.affiliation: Petru Poni Institute of Macromolecular Chemistry, 6600 Iasi, Romania. gmocanu@icmpp.tuiasi.ro
authors.forename: Mocanu
authors.initials: M
authors.lastname: Georgeta
authors.forename: About-Jaudet
authors.initials: AJ
authors.lastname: Elie
authors.forename: LeCerf
authors.initials: L
authors.lastname: Didier
authors.forename: Picton
authors.initials: P
authors.lastname: Luc
authors.forename: Carpov
authors.initials: C
authors.lastname: Adrian
authors.forename: Muller
authors.initials: M
authors.lastname: Guy
mesh_terms: D048271:Chitosan / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry*; D004347:Drug Interactions; D008863:Microspheres; D008970:Molecular Weight; D009268:Nalidixic Acid / Q000737:chemistry / Q000493:pharmacokinetics; D009596:Nitrophenols / Q000737:chemistry / Q000493:pharmacokinetics; D010894:Piroxicam / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D003505:Cyclodextrins; D009596:Nitrophenols; D010894:Piroxicam; D009268:Nalidixic Acid; D048271:Chitosan; C024836:4-nitrophenol