Serotonin-1B receptor activity and expression modulate the aggression-stimulating effects of adolescent anabolic steroid exposure in hamsters.
Repeated high dose (5.0 mg/kg) anabolic-androgenic steroid (AAS) exposure during adolescence stimulates offensive aggression in male Syrian hamsters. These studies examined whether AAS-induced aggression was regulated by the activity of serotonin (5HT) type-1B receptors and correlated with altered 5HT1B expression. AAS-treated hamsters were tested for offensive aggression following the administration of the 5HT1B agonist anpirtoline (0.125-0.5 mg/kg). Anpirtoline dose-dependently reduced select components of the AAS-induced aggressive response, with significant reductions observed at 0.25 mg/kg. Aggressive, AAS-treated hamsters showed significant decreases in the area covered by 5HT1B-containing neuronal puncta and increases in the number of 5HT1B-containing neuronal somata in select brain regions implicated in aggression control. Together, these data support a role for site-specific alterations in 5HT1B signaling and expression in adolescent AAS-induced aggression.
Grimes
Jill M
JM
Behavioral Neuroscience Program, Department of Psychology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.
Melloni
Richard H
RH
D000374:Aggression / Q000187:drug effects*; D000728:Androgens / Q000008:administration & dosage*; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005786:Gene Expression Regulation / Q000187:drug effects*; D008297:Male; D008647:Mesocricetus; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010880:Piperidines / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D011897:Random Allocation; D011930:Reaction Time / Q000187:drug effects; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism / Q000502:physiology*; D012702:Serotonin Antagonists / Q000008:administration & dosage; D018709:Statistics, Nonparametric
D000728:Androgens; D010880:Piperidines; D011725:Pyridines; D044302:Receptor, Serotonin, 5-HT1B; D012702:Serotonin Antagonists; C058376:anpirtolin