title: Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis.
abstract: A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one of three strains of H. hepaticus: type strain Hh3B1, which contains the complete PAI, and strains HhNET and HhG, which lack all or large parts of HHGI1, respectively. Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1.
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-825C, Cambridge, MA 02139, USA.
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Boutin
authors.forename: Zeli
authors.initials: Z
authors.lastname: Shen
authors.forename: Arlin B
authors.initials: AB
authors.lastname: Rogers
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Ge
authors.forename: Sandy
authors.initials: S
authors.lastname: Xu
authors.forename: Torsten
authors.initials: T
authors.lastname: Sterzenbach
authors.forename: Christine
authors.initials: C
authors.lastname: Josenhans
authors.forename: David B
authors.initials: DB
authors.lastname: Schauer
authors.forename: Sebastian
authors.initials: S
authors.lastname: Suerbaum
authors.forename: James G
authors.initials: JG
authors.lastname: Fox
mesh_terms: D000818:Animals; D005260:Female; D016680:Genome, Bacterial; D044404:Genomic Islands / Q000235:genetics*; D044923:Helicobacter hepaticus / Q000235:genetics* / Q000472:pathogenicity*; D006505:Hepatitis / Q000382:microbiology* / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains