title: Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.
abstract: Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.
authors.affiliation: The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA. lzhang@adarc.org
authors.forename: Linqi
authors.initials: L
authors.lastname: Zhang
authors.forename: Fengwen
authors.initials: F
authors.lastname: Zhang
authors.forename: Wenjie
authors.initials: W
authors.lastname: Yu
authors.forename: Tian
authors.initials: T
authors.lastname: He
authors.forename: Jian
authors.initials: J
authors.lastname: Yu
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Yi
authors.forename: Lei
authors.initials: L
authors.lastname: Ba
authors.forename: Wenhui
authors.initials: W
authors.lastname: Li
authors.forename: Michael
authors.initials: M
authors.lastname: Farzan
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Chen
authors.forename: Kwok-Yung
authors.initials: KY
authors.lastname: Yuen
authors.forename: David
authors.initials: D
authors.lastname: Ho
mesh_terms: D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000086462:Coronavirus Nucleocapsid Proteins; D018450:Disease Progression; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology; D009500:Neutralization Tests; D019590:Nucleocapsid Proteins / Q000276:immunology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000503:physiopathology; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000086462:Coronavirus Nucleocapsid Proteins; D008562:Membrane Glycoproteins; D019590:Nucleocapsid Proteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; C578557:spike glycoprotein, SARS-CoV