Endocannabinoid identification in the brain: studies of breakdown lead to breakthrough, and there may be NO hope.
Endocannabinoids are a class of fatty acid derivatives defined by their ability to interact with the specific cannabinoid receptors that were originally identified as the targets of Delta9-tetrahydocannabinol (Delta9-THC), the psychoactive component of cannabis. Endocannabinoids have been implicated in a growing number of important physiological and behavioral events. A full understanding of the functions of endocannabinoids will involve knowing which ones are active, and how they are produced, during any given physical event. However, studying these small lipids in the brain presents many technical challenges. New selective pharmacological tools promise to be very useful in unraveling the complexities of endocannabinoid signaling, but parallel developments from the investigation of the cellular neurophysiology of the endocannabinoid systems highlight the difficulties remaining.
Alger
Bradley E
BE
Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA. balger@umaryland.edu
D000581:Amidohydrolases / Q000502:physiology; D000818:Animals; D001095:Arachidonic Acids / Q000502:physiology; D001923:Brain Chemistry; D063385:Cannabinoid Receptor Modulators / Q000032:analysis* / Q000502:physiology; D063388:Endocannabinoids; D005544:Forecasting; D005989:Glycerides / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000502:physiology; D043882:Receptors, Cannabinoid / Q000187:drug effects / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D050916:TRPV Cation Channels / Q000187:drug effects / Q000502:physiology; D010738:Type C Phospholipases / Q000502:physiology; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D005989:Glycerides; D008055:Lipids; D009569:Nitric Oxide; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled; D050916:TRPV Cation Channels; D010738:Type C Phospholipases; D000099252:Fatty Acid Amide Hydrolases; C094503:glyceryl 2-arachidonate