Sodium selenite protects against diabetes-induced alterations in the antioxidant defense system of the liver.
BACKGROUND
Free radical genesis of disorder is one of the major subjects of discussion in the explanation of pathological conditions. In this study, the effects of micro molar quantities of sodium selenite treatment on diabetes-induced alterations in the antioxidant defense system were investigated.


METHODS
Diabetes was induced by administration of streptozotocin (STZ, 50 mg/kg body weight) and both diabetic and control animals were treated with sodium selenite (5 micromol/kg/day) for 4 weeks.


RESULTS
Our results have shown that induction of diabetes in the liver tissue of animals for 5 weeks resulted in decreased superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GSHPx) activities and concomitantly increased lipid peroxidation (LPO).


CONCLUSIONS
Sodium selenite treatment of the diabetic rats resulted in almost full restoration of all the parameters mentioned above. Metallothionein, which is known to be one of the major antioxidants and a central protein in heavy metal regulation, is altered by diabetes, and sodium selenite treatment restored this alteration as well.
Ayaz
Murat
M
Department of Biophysics, Meram Medical Faculty, Selçuk University, 42080 Konya, Turkey. mayaz@selcuk.edu.tr
Celik
Handan Ak
HA
Aydin
Hikmet Hakan
HH
Turan
Belma
B
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000517:prevention & control; D005260:Female; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000494:pharmacology*
D000975:Antioxidants; D018038:Sodium Selenite