Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival.
We have analyzed mantle cell lymphomas (MCLs), using high-density DNA microarrays, and confirmed the expression of differentially regulated antigens, using flow cytometry and immunohistochemistry. The results show that MCLs acquire expression of molecules that normally are involved in interaction with other immune cells and, thus, might affect the ability of the tumor to survive. The MCL signature is represented by the overexpression of the chemokine CCL4 (MIP-1beta), implicated in the recruitment of regulatory T cells, as well as CCL5 and 4-1BB-L. The latter molecules are normally involved in chemotaxis of T cells and B cell activation, respectively. Signaling through 4-1BB-L allows B cells to proliferate and the expression of its ligand, by the intra-tumoral mesh of follicular dendritic cells (FDC), could thus serve as a paracrine loop facilitating growth and survival of MCL cells.
Ek
Sara
S
Department of Immunotechnology, Lund University, Lund, Sweden.
Björck
Erik
E
Högerkorp
Carl-Magnus
CM
Nordenskjöld
Magnus
M
Porwit-MacDonald
Anna
A
Borrebaeck
Carl A K
CA
D053330:4-1BB Ligand; D002470:Cell Survival; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019742:Chemokines, CC / Q000096:biosynthesis* / Q000235:genetics; D002633:Chemotaxis; D003713:Dendritic Cells; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D020522:Lymphoma, Mantle-Cell / Q000235:genetics* / Q000473:pathology; D019402:Macrophage Inflammatory Proteins / Q000096:biosynthesis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D048069:Tumor Necrosis Factors / Q000096:biosynthesis* / Q000235:genetics
D053330:4-1BB Ligand; C066507:CCL4 protein, human; C483024:CCL5 protein, human; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins; C505974:TNFSF9 protein, human; D048069:Tumor Necrosis Factors