Chemical synthesis approaches to the engineering of ion channels.
Chemoselective ligation strategies have previously provided synthetic access to water-soluble proteins with novel properties, and more recently these strategies have been used to prepare ion channels. Examples of ion channels prepared by total chemical synthesis include bacterial mechanosensitive channels, and viral ion channels. Chemical protein synthesis allows for the generation of ion channel proteins with both native, and engineered structural or conductance properties.
Kochendoerfer
Gerd G
GG
Gryphon Therapeutics, 600 Gateway Boulevard, South San Francisco, CA 94080, USA. gerd@gryphonrx.com
Clayton
Daniel
D
Becker
Christian
C
D000818:Animals; D029968:Escherichia coli Proteins / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D007473:Ion Channels / Q000138:chemical synthesis* / Q000737:chemistry; D008565:Membrane Proteins / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D015202:Protein Engineering / Q000379:methods*
D029968:Escherichia coli Proteins; D007473:Ion Channels; D008565:Membrane Proteins; C086596:MscL protein, E coli; D010455:Peptides