title: Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
abstract: OBJECTIVE
  It is possible that altered control of aldosterone synthase gene (CYP11B2) expression or translation may be responsible for hypertension. Hypertension is one of the major components of preeclampsia. We present here a study investigating the association between the CYP11B2 gene polymorphism in the promoter region at the position of -344 and preeclampsia.
  
  
  METHODS
  We analyzed a group of Turkish women for preeclampsia (n=143), eclampsia (n=36), and the HELLP syndrome (n=55) and compared them with controls (n=147). Genotypes for CYP11B2 were determined by polymerase chain reaction followed by digestion with BsuRI restriction enzyme.
  
  
  RESULTS
  The -344T/T, -344C/T, and -344C/C genotypes were found at comparable frequencies among the study groups, between the study and control groups, and between the study groups combined and the control group (p>0.05). We combined the genotypes of TC and CC (polymorphic) and compared them with the TT (wild-type) genotype. There was no significant difference in the frequency of the TC plus CC genotypes among the study groups, between the study and control groups, and between the study groups combined and the control group (p>0.05). There was no association of the CYP11B2 polymorphism among the preeclampsia, eclampsia, and HELLP groups and controls.
  
  
  CONCLUSIONS
  The CYP11B2 gene polymorphism is not directly associated with preeclampsia, eclampsia, and the HELLP syndrome in women with these conditions. Therefore, this polymorphism may not be a risk factor for these disorders, at least not in the Turkish population.
authors.affiliation: Department of Medical Genetics, Gazi University School of Medicine, Ankara 06500, Turkey. ferdaep@yahoo.com
authors.forename: Ferda E
authors.initials: FE
authors.lastname: Percin
authors.forename: Meral
authors.initials: M
authors.lastname: Cetin
authors.forename: Ergun
authors.initials: E
authors.lastname: Pinarbasi
authors.forename: Egemen
authors.initials: E
authors.lastname: Akgun
authors.forename: Fatma
authors.initials: F
authors.lastname: Gurlek
authors.forename: Ali
authors.initials: A
authors.lastname: Cetin
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004461:Eclampsia / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005865:Gestational Age; D017359:HELLP Syndrome / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D010298:Parity; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D014421:Turkey
chemical_list: D019405:Cytochrome P-450 CYP11B2