Ecto-ADP-ribose transferases: cell-surface response to local tissue injury.
Ecto-ADP-ribose transferases (ecto-ARTs) catalyze the transfer of ADP-ribose from NAD(+) to arginine residues in cell-surface proteins. Since the concentration of extracellular NAD(+) is very low under normal physiological conditions but rises significantly upon tissue injury or membrane stress, it is postulated that the main role of ecto-ARTs is to ADP-ribosylate and regulate the function of certain membrane receptors in response to elevated levels of NAD(+).
Zolkiewska
Anna
A
Department of Biochemistry, Kansas State University, Manhattan, USA. zolkiea@ksu.edu
D036002:ADP Ribose Transferases / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D004194:Disease; D006801:Humans; D014947:Wounds and Injuries / Q000201:enzymology
D036002:ADP Ribose Transferases