Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples.
Desorption electrospray ionisation (DESI) has been successfully combined with a hybrid quadrupole time-of-flight mass spectrometer to provide mass spectra and product ion mass spectra of active ingredients formulated in pharmaceutical tablets, gels and ointments. Accurate mass data has been obtained from the DESI mass spectra and of the product ion fragments of selected ions, greatly enhancing the selectivity and information content of the experiment. This accurate mass information only takes seconds to acquire since the DESI technique does not require any sample preparation or extraction prior to mass analysis.
Williams
Jonathan P
JP
Department of Biological Sciences, University of Warwick, Gibbet Hill Rd, Coventry CV4 7AL, UK. j.p.williams@warwick.ac.uk
Scrivens
James H
JH
D000700:Analgesics / Q000737:chemistry; D003992:Dibucaine / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D006854:Hydrocortisone / Q000737:chemistry; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010627:Phenethylamines / Q000737:chemistry; D011398:Promethazine / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013607:Tablets / Q000737:chemistry; D013997:Time Factors
D000700:Analgesics; D005782:Gels; D004364:Pharmaceutical Preparations; D010627:Phenethylamines; D013607:Tablets; C005096:mebeverine; D011398:Promethazine; D003992:Dibucaine; D006854:Hydrocortisone