Effect of caffeine on the body fat and lipid metabolism of rats fed on a high-fat diet.
The intake of caffeine (CF) at 0.025, 0.05 or 0.1% for 21 days progressively reduced the body fat mass and body fat percentage in Sprague-Dawley (SD) rats fed on a high-fat diet with increasing administration level. Moreover, CF increased the serum concentrations of catecholamines and free fatty acids in SD rats orally administered with CF (5 mg/kg). These results suggest that the intake of CF reduced body fat by lipolysis via catecholamines. CF has potential as a functional food ingredient with an anti-obesity action.
Kobayashi-Hattori
Kazuo
K
Department of Nutritional Sciences, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Japan. k2kobaya@nodai.ac.jp
Mogi
Akie
A
Matsumoto
Yoshinobu
Y
Takita
Toshichika
T
D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D001823:Body Composition; D001835:Body Weight / Q000187:drug effects; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D002395:Catecholamines / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D008066:Lipolysis; D008297:Male; D009765:Obesity / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley
D002395:Catecholamines; D004041:Dietary Fats; D005227:Fatty Acids; D002110:Caffeine