title: VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.
abstract: A transferable plasmid from Klebsiella pneumoniae carried a class 1 integron containing bla(VIM-12), a novel bla(VIM)-type gene, flanked by two copies of aacA7. bla(VIM-12) was clustered between bla(VIM-1) and bla(VIM-2) and differed from bla(VIM-1) by 18 nucleotides that were all located at the 3' end and matched the corresponding nucleotides in bla(VIM-2). The bla(VIM-12)-associated 59-base element was identical to that described in bla(VIM-2) alleles.
authors.affiliation: Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece. pournaras@med.uth.gr
authors.forename: Spyros
authors.initials: S
authors.lastname: Pournaras
authors.forename: Alexandros
authors.initials: A
authors.lastname: Ikonomidis
authors.forename: Leonidas S
authors.initials: LS
authors.lastname: Tzouvelekis
authors.forename: Despoina
authors.initials: D
authors.lastname: Tokatlidou
authors.forename: Nicholas
authors.initials: N
authors.lastname: Spanakis
authors.forename: Antonios N
authors.initials: AN
authors.lastname: Maniatis
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Legakis
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tsakris
mesh_terms: D000483:Alleles; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: C417264:VIM-1 metallo-beta-lactamase; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases; C525149:beta-lactamase VIM-12, Klebsiella pneumoniae