title: [Effect of allopurinol on rat testicles morphology, submitted to ischaemia for spermatic cord torsion followed by reperfusion].
abstract: OBJECTIVE
  In this investigation has been studied the effect of the allopurinol on the reperfusion injury phenomenon in testicles of rats.
  
  
  METHODS
  Eighty adults Wistar rats were divided in 4 groups: sham without allopurinol, sham with allopurinol, right testicular torsion for one hour without allopurinol and right testicular torsion for one hour with allopurinol. Bilateral orchiectomy was performed 60 days of the experiment and the testis were processed for optical microscopy, and examined to asses the seminiferous ducts and the spermatogenic cells.
  
  
  RESULTS
  There was significant atrophy and histological damage of the right testis.
  
  
  CONCLUSIONS
  Allopurinol did not protected the testis against the effects of the reperfusion injury.
authors.affiliation: Universidade Federal de São Paulo, Escola Paulista de Medicina. abrochado@hotmail.com
authors.forename: Andréia C M Brochado Antoniolli
authors.initials: AC
authors.lastname: Silva
authors.forename: Valdemar
authors.initials: V
authors.lastname: Ortiz
authors.forename: Roberto Antoniolli da
authors.initials: RA
authors.lastname: Silva
authors.forename: João Ricardo
authors.initials: JR
authors.lastname: Tognini
mesh_terms: D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*; D013086:Spermatic Cord Torsion / Q000473:pathology* / Q000628:therapy; D013733:Testicular Diseases / Q000517:prevention & control; D013737:Testis / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology
chemical_list: D016166:Free Radical Scavengers; D000493:Allopurinol