title: Tungtungmadic acid, a novel antioxidant, from Salicornia herbacea.
abstract: Tungtungmadic acid (3-caffeoyl-4-dihydrocaffeoyl quinic acid) is a new chlorogenic acid derivative that was isolated from the Salicornia herbacea. The structure of tungtungmadic acid was determined using chemical and spectral analysis. The antioxidant activity of tungtungmadic acid was evaluated using various antioxidant assays, including free radical scavenging, lipid peroxidation and hydroxyl radical-induced DNA strand breaks assays. Tungtungmadic acid (IC50 = 5.1 microM and 9.3 microM) was found to have higher antioxidant activity in the DPPH scavenging assay as well as in the iron-induced liver microsomal lipid peroxidation system. In addition, the tungtungmadic acid was also effective in protecting the plasmid DNA against strand breakage induced by hydroxyl radicals.
authors.affiliation: Division of Food Science, Chinju International University, Chinju, Korea. fnjung@hanmail.net
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Chung
authors.forename: Hyo Kon
authors.initials: HK
authors.lastname: Chun
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Yang
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Han
authors.forename: Yung Hee
authors.initials: YH
authors.lastname: Kho
authors.forename: Hye Gwang
authors.initials: HG
authors.lastname: Jeong
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002726:Chlorogenic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D002726:Chlorogenic Acid