title: Inflammatory markers and hepatocyte growth factor in sustained hemodialysis hypotension.
abstract: Hypotension is an important complication of hemodialysis. The pathogenesis of this complication remains unclear. The role of chronic inflammation in chronic dialysis-associated hypotension has not been investigated. A total of 38 dialysis patients with chronic hypotension were identified. Their demographic and biochemical data, inflammatory markers (high sensitivity C-reactive protein [hs-CRP] and interleukin-6 [IL-6]), hepatocyte growth factor (HGF), leptin, and adiponectin levels were measured and compared with those of another 87 nonhypotensive dialysis patients. No between-group differences in their clinical features, underlying renal disease were found. Levels of serum albumin, leptin, adiponectin, and HGF were similar between the two groups. The serum albumin levels were inversely correlated with hs-CRP and IL-6. Adiponectin was negatively correlated with hs-CRP and leptin. HGF showed a positive relation with hs-CRP. No association was found between adiponectin and HGF. Therefore, chronic inflammation is prevalent in the dialysis population, and serum HGF level is associated with inflammation but not with chronic dialysis hypotension.
authors.affiliation: Division of Nephrology, Department of Medicine, Chang-Gung Memorial Hospital, Kaohsiung, Taiwan. ctlee33@adm.cgmh.org.tw
authors.forename: Chien-Te
authors.initials: CT
authors.lastname: Lee
authors.forename: Chung-Yao
authors.initials: CY
authors.lastname: Hsu
authors.forename: Kim-Kwan
authors.initials: KK
authors.lastname: Lam
authors.forename: Chung-Ren
authors.initials: CR
authors.lastname: Lin
authors.forename: Jin-Bor
authors.initials: JB
authors.lastname: Chen
mesh_terms: D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007022:Hypotension / Q000097:blood* / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012709:Serum Albumin / Q000032:analysis
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D012709:Serum Albumin; D017228:Hepatocyte Growth Factor; D002097:C-Reactive Protein