Effects of total coronary artery occlusion on vascular endothieial growth factor and transforming growth factor beta.
Vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-beta1) play an important role in angiogenesis. We wanted to determine if concentrations of growth factors in the coronary sinus (CS) and right atrium (RA) are higher in coronary artery disease patients with total occlusions than in those with partial occlusions. Fifty-one patients scheduled for coronary artery angiography were evaluated for possible recruitment. A 6F Goodale-Lubin catheter was used to collect blood from the CS and RA. Data for all but four patients were gathered successfully, leaving 47 study patients. The reviewer was blinded to growth factor data when interpreting coronary angiographic findings. Of the 47 enrolled patients, 32 had at least one diseased vessel, seven of whom had at least one major total epicardial coronary occlusion. In all 32 patients, the concentrations of VEGF in the CS were higher than those in the RA (31.5 +/- 2.7 vs 27.1 +/- 1.8 pg/mL; p = 0.005). Patients with total occlusions had higher VEGF concentrations in the CS than those with non-total occlusions (38.9 +/- 8.0 vs 29.5 +/- 2.6 pg/mL; p = 0.037). The differences in TGF-beta1 in the two groups were not statistically significant. The higher CS VEGF concentrations in patients with total occlusion indicate that VEGF may play a part in the development of angiogenesis.
Lin
Tsung-Hsien
TH
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Chun-Ho Memorial Hospital, Taiwan.
Yen
Hsueh-Wei
HW
Su
Ho-Ming
HM
Chien
Wan-Ting
WT
Lu
Ye-Hsu
YH
Voon
Wen-Chol
WC
Lai
Wen-Ter
WT
Sheu
Sheng-Hsiung
SH
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000150:complications; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D023921:Coronary Stenosis / Q000097:blood; D003331:Coronary Vessels / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006325:Heart Atria / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A