title: Morpheaform extra-ocular sebaceous carcinoma.
abstract: BACKGROUND
  Sebaceous carcinoma is an unusual, aggressive, malignant tumor derived from the epithelium of sebaceous glands. It may arise in ocular or extra-ocular sites and is often evident as an ulcerated or non-ulcerated cystic nodule measuring up to 8 cm in diameter. A significant number of extra-ocular sebaceous carcinomas have been associated with metastases and high mortality rate.
  
  
  RESULTS
  We reviewed the literature in the context of our report of a 68-year-old woman who had a morpheaform plaque of the upper lip of 15 years duration, extending into the left naso-genal groove, which histologically also showed marked stromal fibrosis. Three years after excision, there were no signs of recurrence or metastases.
  
  
  CONCLUSIONS
  This patient is unusual in clinical and histologic pattern, as a morpheaform appearance has only been described previously in only one sebaceous carcinoma. In addition, no metastatic disease 15 years after tumor onset is a fortunate and remarkable feature.
authors.affiliation: Dermatology and Plastic Surgery, University La Sapienza, Rome, Italy. daniele.innocenzi@uniroma1.it
authors.forename: D
authors.initials: D
authors.lastname: Innocenzi
authors.forename: A
authors.initials: A
authors.lastname: Balzani
authors.forename: F
authors.initials: F
authors.lastname: Lupi
authors.forename: C
authors.initials: C
authors.lastname: Panetta
authors.forename: N
authors.initials: N
authors.lastname: Skroza
authors.forename: F
authors.initials: F
authors.lastname: Cantoresi
authors.forename: R A
authors.initials: RA
authors.lastname: Schwartz
authors.forename: S
authors.initials: S
authors.lastname: Calvieri
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000150:complications / Q000473:pathology* / Q000601:surgery; D000368:Aged; D005260:Female; D005355:Fibrosis; D006801:Humans; D008046:Lip / Q000473:pathology*; D012594:Scleroderma, Localized / Q000150:complications / Q000473:pathology*; D012626:Sebaceous Gland Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery