[Application of double-filtration plasmapheresis in major ABO-incompatible unrelated bone marrow transplantation].
OBJECTIVE
To evaluate the effect of double-filtration plasmapheresis (DFPP) in major ABO-incompatible unrelated allogenic bone marrow transplantation.


METHODS
The red cell antibodies were removed by DFPP in 5 recipients to prevent hemolysis and pure red cell aplasia following major ABO-incompatible unrelated bone marrow transplantation.


RESULTS
The isohemagglutinin titers of the 5 recipients were below 1:16 after DFPP with only one recipient developed transient mild acute hemolysis. Delayed hemolysis and pure red cell aplasia occurred in none of the cases and all recipients were completely engrafted.


CONCLUSIONS
DFPP can effectively prevent hemolysis and pure red cell aplasia in recipients of unrelated bone marrow transplantation with major ABO-incompatibility.
Huang
Tao
T
Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. aoyunhui@fimmu.com
Sun
Jing
J
Liu
Jun
J
Liu
Qi-fa
QF
Men
Fang-yi
FY
D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D001787:Blood Group Incompatibility; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology; D005260:Female; D005374:Filtration; D006461:Hemolysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D012010:Red-Cell Aplasia, Pure / Q000517:prevention & control; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000276:immunology / Q000379:methods
D000017:ABO Blood-Group System