title: Severe systemic hypersensitivity reaction to ibuprofen: a presentation of systemic lupus erythematosus.
abstract: We describe the first severe systemic hypersensitivity reaction to ibuprofen in a pediatric patient with previously undiagnosed systemic lupus erythematosus (SLE). An 11-year-old Thai male presented with fever, rash, altered mental status, and hypotension after oral administration of ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted in recurrence of presenting symptoms. Severe hypersensitivity with hypotension can be a rare consequence of the use of ibuprofen in children with collagen vascular disease. When encountered in an otherwise healthy child, a high index of suspicion must be maintained for the diagnosis of SLE.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical School, USA.
authors.forename: Steven S
authors.initials: SS
authors.lastname: Mou
authors.forename: Lynn
authors.initials: L
authors.lastname: Punaro
authors.forename: Jordi
authors.initials: J
authors.lastname: Antón
authors.forename: Peter M
authors.initials: PM
authors.lastname: Luckett
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002648:Child; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000209:etiology; D007052:Ibuprofen / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen