[Catalytic autoantibodies in autoimmune myocarditis: clinical and pathogenetic implications].
OBJECTIVE
To evaluate pathogenetic and clinical significance of autoantibodies (AAB) with catalytic activity in the serum of patients with autoimmune myocarditis (AM).


METHODS
The study was made on the sera from 99 patients with AM of different course: malignant, benign, myocardiosclerosis (MCS). In addition to standard immunological parameters, the study was made of serum levels of anticardiomyosine-antiCM (protabzymes) and anti-DNA (DNA-abzymes) of AAB. After obtaining anti-CM and anti-DNA IgG-AT, we determined non-specific and specific proteolytic activity of anti-CM.


RESULTS
Maximal specific activity of protabzymes was seen in 73% patients with malignant AM, it correlated with blood levels of anti-CM AAB, DNA-abzymes activity was very high in 45% patients. In MCS proteolytic activity of autoAT was absent in 61% patients. In benign AM occurrence of protabzymes was confirmed in 35% cases. Elevated DNA-hydrolyzing activity of DNA-abzymes occurred in 13% cases. The activity had no significant correlation with serum titers of AB. In MCS proteolytic activity of AAB was absent in 61% cases, but high activity of anti-CM AAB was in 28%. The activity of DNA-abzymes in 44% ranged considerably which, in seropositive cases, detected significant correlation with serum titers of DNA-binding autoAT.


CONCLUSIONS
Evaluation of catalytic activity of AAB may be considered as a criterial test assessing the stage, clinical variants and severity of AM. It also permits formulation of the disease prognosis and its possible outcomes.
Kalinina
E V
EV
Ponomarenko
N A
NA
Durova
O M
OM
Paleev
F N
FN
Vorob'ev
I I
II
Kekenadze
N N
NN
Shogenov
Z S
ZS
Zemtsova
M E
ME
Gnuchev
N V
NV
Gabibov
A G
AG
D017151:Antibodies, Catalytic / Q000097:blood* / Q000378:metabolism; D001323:Autoantibodies / Q000097:blood* / Q000235:genetics; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D024722:Cardiac Myosins / Q000276:immunology; D002384:Catalysis; D004247:DNA / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics; D009205:Myocarditis / Q000175:diagnosis* / Q000276:immunology; D011379:Prognosis
D017151:Antibodies, Catalytic; D001323:Autoantibodies; D007074:Immunoglobulin G; D004247:DNA; D024722:Cardiac Myosins