title: [Splanchnic remodeling secondary to experimental prehepatic portal hypertension].
abstract: OBJECTIVE
  Portal hypertension as an inducer of intestinal inflammatory response would cause epithelial and splanchnic vascular remodeling in the long-term. This experimental study was carried out to verify this hypothesis.
  
  
  METHODS
  Structural alterations characteristic of intestinal epithelial and mesenteric vascular remodeling, the density of goblet cells and the diameter of mesenteric vein branches were studied, respectively, in rats with partial portal vein ligation in the short (1 month) and long-term (1 year).
  
  
  RESULTS
  Hyperplasia of goblet cells in the small intestine (duodenum, jejunum, ileum) is maximum after 1 year of evolution of the portal hypertension and is associated with dilatation of the distal branches (3rd and 4th order) of the superior mesenteric vein.
  
  
  CONCLUSIONS
  Long-term splanchnic remodeling in experimental portal hypertension suggests the existence of a chronic inflammatory process in this clinical condition.
authors.affiliation: Servicio de Anatomía Patológica, Hospital Carlos III, Madrid. corcuera.hciii@salud.madrid.org
authors.forename: M T
authors.initials: MT
authors.lastname: Corcuera Pindado
authors.forename: M P
authors.initials: MP
authors.lastname: Nava Hidalgo
authors.forename: A
authors.initials: A
authors.lastname: Angulo Burgos
authors.forename: M A
authors.initials: MA
authors.lastname: Aller Reyero
authors.forename: F
authors.initials: F
authors.lastname: Gómez Aguado
authors.forename: I
authors.initials: I
authors.lastname: Casado Fariñas
authors.forename: M J
authors.initials: MJ
authors.lastname: Alonso Martín
authors.forename: A Jaime
authors.initials: AJ
authors.lastname: Pérez
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006965:Hyperplasia; D006975:Hypertension, Portal / Q000503:physiopathology*; D007249:Inflammation; D007421:Intestine, Small / Q000098:blood supply / Q000473:pathology; D008297:Male; D008642:Mesenteric Veins / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013152:Splanchnic Circulation / Q000502:physiology*