[Antenatal closure of ductus arteriosus following maternal intoxication by niflumic acid].
Antenatal closure of the ductus arteriosus is an uncommon event that has been considered as a risk factor for development of congestive heart failure and persistent pulmonary hypertension of the newborn. We report here on a case of antenatal ductus arteriosus closure due to niflumic acid maternal intoxication at 32 weeks of gestation. Fetal extraction was performed few days later because of echographic signs of congestive heart failure. The child survived after 3 days of severe persistent pulmonary hypertension. This case emphasizes the potential risk of niflumic acid during pregnancy and the need of antenatal echographic monitoring for optimal management.
Bouissou
A
A
Unité de néonatologie, hôpital des enfants, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 09, France.
Glorieux
I
I
Dulac
Y
Y
Marcoux
M O
MO
Casper
C
C
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D004374:Ductus Arteriosus, Patent / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D009544:Niflumic Acid / Q000506:poisoning*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D011263:Pregnancy Trimester, Third; D012307:Risk Factors; D014463:Ultrasonography
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009544:Niflumic Acid