title: High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women.
abstract: The Connective Tissue Disease Screening Questionnaire (CSQ), developed to screen populations for SLE and other CTDs, has been validated in a predominantly Caucasian population with hospital-based controls. We aimed to test the performance characteristics of the CSQ in an urban, predominantly African-American population. The CSQ was administered by interview to women recruited for a study of environmental risk factors and SLE, including 99 cases with SLE validated by medical record review and 202 healthy controls recruited from the community. Overall, 88% of subjects had African heritage, 6% were Hispanic and 4% were non-Hispanic Caucasian. Controls were more likely to report African heritage than cases (91% versus 82%, P = 0.001). Sensitivity for detecting SLE was 88% and specificity was 91%. In this study, where the prevalence of SLE was 33%, predictive value of a positive CSQ was 82% and predictive value of a negative CSQ was 94%. The CSQ has slightly lower sensitivity but greater specificity for SLE in an urban, predominantly African-American population with community-based controls compared with a Caucasian population with hospital-based controls. These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ekarlson@partners.org
authors.forename: E W
authors.initials: EW
authors.lastname: Karlson
authors.forename: K H
authors.initials: KH
authors.lastname: Costenbader
authors.forename: T E
authors.initials: TE
authors.lastname: McAlindon
authors.forename: E M
authors.initials: EM
authors.lastname: Massarotti
authors.forename: L M
authors.initials: LM
authors.lastname: Fitzgerald
authors.forename: R
authors.initials: R
authors.lastname: Jajoo
authors.forename: E
authors.initials: E
authors.lastname: Husni
authors.forename: E A
authors.initials: EA
authors.lastname: Wright
authors.forename: H
authors.initials: H
authors.lastname: Pankey
authors.forename: P A
authors.initials: PA
authors.lastname: Fraser
mesh_terms: D000328:Adult; D001741:Black or African American; D005188:False Negative Reactions; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000208:ethnology; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D014505:Urban Population; D044465:White People