Intramolecular alkyne hydroalkoxylation and hydroamination catalyzed by iridium hydrides.
[reaction: see text] Iridium(III) hydrides prove to be air-stable active catalysts for intramolecular hydroalkoxylation and hydroamination of internal alkynes with proximate nucleophiles. The cyclization follows highly selective 6-endo-dig regiochemistry when regioselectivity is an issue.
Li
Xingwei
X
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA.
Chianese
Anthony R
AR
Vogel
Tiffany
T
Crabtree
Robert H
RH