title: Protein variety and functional diversity: Swiss-Prot annotation in its biological context.
abstract: We all know that the dogma 'one gene, one protein' is obsolete. A functional protein and, likewise, a protein's ultimate function depend not only on the underlying genetic information but also on the ongoing conditions of the cellular system. Frequently the transcript, like the polypeptide, is processed in multiple ways, but only one or a few out of a multitude of possible variants are produced at a time. An overview on processes that can lead to sequence variety and structural diversity in eukaryotes is given. The UniProtKB/Swiss-Prot protein knowledgebase provides a wealth of information regarding protein variety, function and associated disorders. Examples for such annotation are shown and further ones are available at http://www.expasy.org/sprot/tutorial/examples_CRB.
authors.affiliation: Swiss Institute of Bioinformatics, Centre Médical Universitaire, 1, rue Michel-Servet, 1211 Genève 4, Switzerland. brigitte.boeckmann@isb-sib.ch
authors.forename: Brigitte
authors.initials: B
authors.lastname: Boeckmann
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Blatter
authors.forename: Livia
authors.initials: L
authors.lastname: Famiglietti
authors.forename: Ursula
authors.initials: U
authors.lastname: Hinz
authors.forename: Lydie
authors.initials: L
authors.lastname: Lane
authors.forename: Bernd
authors.initials: B
authors.lastname: Roechert
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
mesh_terms: D000595:Amino Acid Sequence; D051188:Knowledge Bases; D008969:Molecular Sequence Data; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins