title: [Differential expression of human macrophage genes encoding cytokines and their regulatory elements after Mycobacterium tuberculosis infection].
abstract: To investigate whether the genes encoding cytokines and their regulatory elements participated in the immune response to Mycobacterium tuberculosis infection. Expression microarray was employed to compare the avirulent strain and clinically isolated strains infection induced macrophage cytokine differential expression. Results were cytokines IFN, TNF, TGF, IL and their regulatory elements are involved in the immune reaction. IL-19 was first reported to be involved in the anti-Mtb immunity. Relative expression level of theses factors before and after infection were assayed too. The data provides clues for further scrutinize the role of cytokines and related elements in the interaction between Mycobacterium tuberculosis and host macrophage.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China. jianpingxie@vip.sina.com
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Yue
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Xu
authors.forename: Honghai
authors.initials: H
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.forename: Shanqian
authors.initials: S
authors.lastname: Yu
authors.forename: Changhua
authors.initials: C
authors.lastname: Hu
mesh_terms: D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D015870:Gene Expression; D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity / Q000502:physiology*; D050436:Regulatory Elements, Transcriptional; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D020298:U937 Cells; D014774:Virulence
chemical_list: D016207:Cytokines