Synthesis of two 3,5-disubstituted sulfonamide catechol ligands and evaluation of their iron(III) complexes for use as MRI contrast agents.
Two 3,5-disubstituted sulfonamide catechol ligands were synthesized. Tris(ligand) iron(III) complexes were prepared and investigated as MRI contrast agents. Longitudinal relaxivity (r1) values were determined for the complexes. The r1 values in water were substantially higher than those of typical six-coordinate iron(III) complexes. The r1 values in plasma under the same conditions increased. The iron(III) complexes were administered to rats, and the kidney and liver signal intensities were measured by T1-weighted MR imaging experiments.
Schwert
Daniel D
DD
Department of Chemistry, University of Toledo, 2801 W. Bancroft Street, Toledo, Ohio 43606, USA. dschwert@ius.edu
Richardson
Nicholas
N
Ji
Gongjun
G
Radüchel
Bernd
B
Ebert
Wolfgang
W
Heffner
Peter E
PE
Keck
Rick
R
Davies
Julian A
JA
D000818:Animals; D002396:Catechols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019786:Gadolinium DTPA / Q000494:pharmacology; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007668:Kidney / Q000033:anatomy & histology; D008024:Ligands; D008099:Liver / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D002396:Catechols; D003287:Contrast Media; D005290:Ferric Compounds; D007502:Iron Chelating Agents; D008024:Ligands; D013449:Sulfonamides; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA