title: Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms.
abstract: In Göttingen, Germany, circadian variations in melatonin had been determined time-macroscopically in pineal glands, blood plasma and duodenum of chicken and rats. When these data were meta-analyzed, they agreed with the results from an independent survey on tissues from rats collected in a laboratory in Pécs, Hungary. In the latter study, tissues were analyzed chemically in Bratislava, Slovakia, and numerically in Minneapolis, MN, USA, all by single- and multiple-component cosinor and parameter tests. In rats and chickens, these inferential statistical procedures clearly demonstrated a lead in phase of the 24-h cosine curves best fitting all of the duodenal vs. those best fitting all of the pineal melatonin values in each species in 2 geographic (geomagnetic) locations. The 24-h cosine curve of circulating melatonin was found to be in an intermediate phase position. Mechanisms of the phase differences and the contribution of gastrointestinal melatonin to circulating hormone concentrations are discussed.
authors.affiliation: Institute of Zoology, Anthropology and Developmental Biology, University of Göttingen, Göttingen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Poeggeler
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: G
authors.initials: G
authors.lastname: Huether
authors.forename: R
authors.initials: R
authors.lastname: Hardeland
authors.forename: R
authors.initials: R
authors.lastname: Józsa
authors.forename: M
authors.initials: M
authors.lastname: Zeman
authors.forename: K
authors.initials: K
authors.lastname: Stebelova
authors.forename: A
authors.initials: A
authors.lastname: Oláh
authors.forename: G
authors.initials: G
authors.lastname: Bubenik
authors.forename: W
authors.initials: W
authors.lastname: Pan
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
authors.forename: O
authors.initials: O
authors.lastname: Schwartzkopff
authors.forename: E E
authors.initials: EE
authors.lastname: Bakken
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000818:Animals; D002645:Chickens; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm / Q000502:physiology*; D003627:Data Interpretation, Statistical; D004386:Duodenum / Q000378:metabolism*; D004574:Electromagnetic Fields; D005843:Geography; D008297:Male; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008550:Melatonin