title: Association of leukocyte activation, but not the common cold, with restenosis after percutaneous coronary intervention in patients with angina pectoris.
abstract: We investigated the relationship between the common cold and restenosis after percutaneous coronary intervention (PCI) in Japanese patients with angina pectoris, because suffering from a common cold during the follow-up period after PCI may be involved in the development of restenosis. In addition, we measured the soluble (s) L-selectin level early after PCI in patients with and without restenosis. The study group included 104 effort angina pectoris patients. We examined whether or not they had had a common cold in the 6 months following angioplasty. Finally, 88 patients, whose common cold status was known, were selected as the study subjects. Twelve patients caught a common cold after PCI. All of these patients were given antibiotics and/or anti-inflammatory agents and recovered within 2 weeks. None had clinically detectable influenza infection. Thirty-three patients suffered from restenosis and 55 did not. There was no significant difference in the restenosis frequency between effort angina pectoris patients with and without a common cold. The sL-selectin level was significantly increased in patients with restenosis early after PCI, whereas in patients without restenosis, sL-selectin remained unchanged. These findings suggest that restenosis development after PCI in patients with effort angina pectoris may involve leukocyte activation early after PCI, while suffering from a common cold during the follow-up period after PCI has no effect.
authors.affiliation: Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Inami
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Sutani
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Nakamori
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Tsuda
authors.forename: S
authors.initials: S
authors.lastname: Fukuhara
authors.forename: T
authors.initials: T
authors.lastname: Iwasaka
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000150:complications / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D003139:Common Cold / Q000097:blood* / Q000188:drug therapy; D023903:Coronary Restenosis / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D019041:L-Selectin