Peripheral blood phagocyte CD14 and CD11b expression on admission to hospital in relation to mortality among patients with community-acquired infection.
OBJECTIVE
Prognostic value of markers of systemic inflammation were evaluated in patients admitted to hospital.


METHODS
The study comprises 327 patients with community- acquired infection verified on admission (n=290) or within 3-day follow-up (n=37).


METHODS
On-admission levels of phagocyte CD11b/CD18 and CD14 expression were measured using whole blood flow cytometry. Clinical data were collected retrospectively from medical records.


RESULTS
In univariate analysis, non-survivors as compared to survivors had higher age, lower arterial pressure, higher heart rate, and lower monocyte CD14 density. In multivariate analysis high age [relative mortality RR 1.05 (95% CI 1.01 to 1.08), p=0.016] and low CD 14 expression on monocytes [RR 7.49 (CI 1.63 to 34.33), p=0.01] remained predictive for the 28-day mortality.


CONCLUSIONS
In patients with community-acquired infection, low on-admission level of monocyte CD14 is related to fatal outcome.
Aalto
H
H
The Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014 Helsinki, Finland. hannele.aalto@helsinki.fi
Takala
A
A
Kautiainen
H
H
Repo
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D039481:CD11b Antigen / Q000378:metabolism*; D017714:Community-Acquired Infections / Q000276:immunology* / Q000401:mortality*; D005260:Female; D006760:Hospitalization; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism*; D015996:Survival Rate; D013997:Time Factors
D039481:CD11b Antigen; D018950:Lipopolysaccharide Receptors