title: Control of neuromuscular blockade in the presence of sensor faults.
abstract: The problem of embedding sensor fault tolerance in feedback control of neuromuscular blockade is considered. For tackling interruptions of feedback measurements, a structure based upon Bayesian inference as well as a predictive filter is proposed. This algorithm is general and can be applied to different situations. Here, it is incorporated in an adaptive automatic system for feedback control of neuromuscular blockade using continuous infusion of muscle relaxants. A significant contribution consists in the experimental clinical testing of the algorithm in patients undergoing surgery.
authors.affiliation: INESC-ID/IST, Lisboa, Portugal.
authors.forename: João M
authors.initials: JM
authors.lastname: Lemos
authors.forename: Hugo
authors.initials: H
authors.lastname: Magalhães
authors.forename: Teresa
authors.initials: T
authors.lastname: Mendonça
authors.forename: Rui
authors.initials: R
authors.lastname: Dionísio
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D004576:Electromyography / Q000379:methods*; D005246:Feedback / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D019148:Neuromuscular Blockade / Q000379:methods*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D009466:Neuromuscular Blocking Agents