title: Determinants of red blood cell transfusions in a pediatric critical care unit: a prospective, descriptive epidemiological study.
abstract: OBJECTIVE
  To determine the incidence and to characterize the determinants of red blood cell transfusions in critically ill children.
  
  
  METHODS
  Prospective, descriptive epidemiologic study.
  
  
  METHODS
  A single-center, multidisciplinary, tertiary care level, university-affiliated, pediatric intensive care unit (PICU).
  
  
  METHODS
  Critically ill children.
  
  
  METHODS
  None.
  
  
  RESULTS
  Of 1,047 consecutive admissions over a 1-yr period, 985 were retained for study. At least one transfusion was given in 139 cases (14%). Incidence rate of transfusion was 304 transfusions/1,000 cases. Possible determinants of red blood cell transfusions were identified and prospectively monitored during PICU stay until a first transfusion event (transfused cases) or up until the time of death or discharge from PICU (nontransfused cases). Four significant determinants of a first red blood cell transfusion event were retained in the multivariate analysis (odds ratio, 95% confidence interval, p): a hemoglobin level <9.5 g/dL during PICU stay (13.26, 8.04-21.88, p < .001), an admission diagnosis of cardiac disease (8.07, 5.14-14.65, p < .001), an admission Pediatric Risk of Mortality score >10 (4.83, 2.33-10.04, p < .001), and the presence of multiple organ dysfunction syndrome during the stay (2.06, 1.18-3.57, p = .01).
  
  
  CONCLUSIONS
  A significant proportion of critically ill children receive at least one red blood cell transfusion during their PICU stay. Presence of anemia, cardiac disease, severe critical illness, and multiple organ dysfunction syndrome are the most significant determinants of red blood cell transfusions in PICU.
authors.affiliation: Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Montréal, Canada.
authors.forename: Ruth
authors.initials: R
authors.lastname: Armano
authors.forename: France
authors.initials: F
authors.lastname: Gauvin
authors.forename: Thierry
authors.initials: T
authors.lastname: Ducruet
authors.forename: Jacques
authors.initials: J
authors.lastname: Lacroix
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods*; D017707:Erythrocyte Transfusion / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D011446:Prospective Studies