title: Residue depletion of eprinomectin in bovine tissues after subcutaneous administration.
abstract: A study of the tissue depletion of eprinomectin (EPR) subcutaneously administered to cattle at a dose of 500 mg per kg of body weight was carried out. EPR concentrations were determined in muscle, liver, kidney, and fat. Twenty-four parasite-free cross cattle were treated with the EPR injectable oil formulation. Three treated animals (two males and one female) were selected randomly to be sacrificed at 1, 3, 7, 14, 21, 28, 42, and 56 days withdrawal after injection. EPR residue concentrations were determined using HPLC with fluorescence detection. Muscle samples showed the lowest EPR concentrations throughout the study period. The highest EPR concentrations at all sampling times were measured in liver tissue, indicating that liver is a target tissue for EPR. EPR concentrations in all of the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 8 days posttreatment.
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University, Beijing 100094, People's Republic of China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Jiang
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Hou
authors.forename: Shuangyang
authors.initials: S
authors.lastname: Ding
authors.forename: Sijun
authors.initials: S
authors.lastname: Zhao
authors.forename: Jihong
authors.initials: J
authors.lastname: He
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Shen
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002417:Cattle / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D009132:Muscles / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C101434:eprinomectin