Refractory severe ocular hypertension after intravitreal triamcinolone acetonide injection.
OBJECTIVE
To report a serious complication following intravitreal triamcinolone acetonide injection.


METHODS
Observational case report.


RESULTS
In 2 patients, secondary intractable severe ocular hypertension occurred 2 months after a single 4-mg intravitreal injection of triamcinolone acetonide for macular edema. Both patients required trabeculectomy intervention to control intraocular pressure (IOP).


CONCLUSIONS
We highlight the occurrence of intractable high IOP elevation as a serious complication 2 months after intravitreal triamcinolone acetonide. Cautious monitoring of IOP for several months after this therapy is recommended. The risks of this potentially devastating complication need to be weighed against the benefits of intravitreal triamcinolone in the individual patient.
Yang
Chang-Sue
CS
Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan, ROC. csyang@vghtpe.gov.tw
Chen
Mei-Ju
MJ
Chou
Ching-Kuang
CK
Hsu
Wen-Ming
WM
D000959:Antihypertensive Agents / Q000627:therapeutic use; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000188:drug therapy / Q000601:surgery; D014130:Trabeculectomy; D014222:Triamcinolone Acetonide / Q000009:adverse effects*; D014822:Vitreous Body
D000959:Antihypertensive Agents; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide