Copper-catalyzed arylation of amines using diphenyl pyrrolidine-2-phosphonate as the new ligand.
[Chemical reaction: See text] We have developed a general, efficient, and inexpensive catalyst system for arylation of amines by using 10 mol % of CuI as the copper source, 20 mol % of diphenyl pyrrolidine-2-phosphonate (DPP) as the ligand, K3PO4 as the base, and DMF containing 2% water (v/v) as the solvent.
Rao
Honghua
H
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P R China.
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000215:Acylation; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry; D001713:Biphenyl Compounds; D002384:Catalysis; D003300:Copper; D004159:Diphenylamine / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D008968:Molecular Conformation; D063065:Organophosphonates / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D000588:Amines; D001555:Benzene Derivatives; D001713:Biphenyl Compounds; D003300:Copper; D004159:Diphenylamine; D008024:Ligands; D063065:Organophosphonates; D011759:Pyrrolidines; C041588:dodecylbenzene; C010574:biphenyl