A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog.
Hyperadrenocorticism, a disorder characterized by excessive production of cortisol by the adrenal cortex, is well-recognized in dogs. A 10-year-old, intact male, Yorkshire terrier dog was evaluated because of corneal ulceration and generalized alopecia. Diagnosis was made based on history taking, clinical signs, physical examination, and results of routine laboratory testing (complete blood count, serum biochemical analysis, and urinalysis). In addition, adrenocorticotropic hormone (ACTH) stimulation test and abdominal ultrasonography were also used to diagnose this case. The patient was diagnosed as adrenal gland neoplasia and medical therapy using the adrenocorticolytic agent, mitotane, was initiated. An ACTH stimulation test was performed after initial therapy. After successful induction was obtained, maintenance therapy with mitotane still continued.
Lee
Young-Mi
YM
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
Kang
Byeong-Teck
BT
Jung
Dong-in
DI
Park
Chul
C
Kim
Ha-Jung
HJ
Kim
Ju-Won
JW
Lim
Chae-Young
CY
Park
Eun-Hee
EH
Park
Hee-Myung
HM
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D008297:Male; D008939:Mitotane / Q000627:therapeutic use*; D011860:Radiography, Abdominal / Q000662:veterinary; D014056:Tomography, X-Ray / Q000662:veterinary
D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane; D000324:Adrenocorticotropic Hormone