title: Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivatives.
abstract: The synthesis by microwave irradiation and the biological results of novel benzotriazinone and saccharine derivatives with potential antidiarrhoeal activity is described. Conventional and microwave heatings were compared for the reactions. Good yields and short reaction times are the main advantages of our synthetic route. Among the tested compounds, compound 12 inhibited motility both in in-vitro and in-vivo tests.
authors.affiliation: Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli, "Federico II", Napoli, Italy.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Fiorino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Caliendo
authors.forename: Elisa
authors.initials: E
authors.lastname: Perissutti
authors.forename: Beatrice
authors.initials: B
authors.lastname: Severino
authors.forename: Francesco
authors.initials: F
authors.lastname: Frecentese
authors.forename: Barbara
authors.initials: B
authors.lastname: Preziosi
authors.forename: Angelo A
authors.initials: AA
authors.lastname: Izzo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Capasso
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Santagada
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D004558:Electric Stimulation; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D008813:Mice, Inbred ICR; D008872:Microwaves; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D012439:Saccharin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000930:Antidiarrheals; D014227:Triazines; D012439:Saccharin