Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.
The CH(2)Cl(2)-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 microg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 microg/ml.
Awale
Suresh
S
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Nakashima
Eduardo M N
EM
Kalauni
Surya K
SK
Tezuka
Yasuhiro
Y
Kurashima
Yukiko
Y
Lu
Jie
J
Esumi
Hiroyasu
H
Kadota
Shigetoshi
S
D029969:Angelica / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D013997:Time Factors; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003374:Coumarins; D010936:Plant Extracts; C508941:angelmarin