title: Intracavitary chemotherapy (Gliadel) for recurrent esthesioneuroblastoma: case report and review of the literature.
abstract: Esthesioneuroblastoma is an uncommon malignancy of the nasal vault with a treatment regimen consisting of surgical resection followed by radiotherapy for primary lesions and addition of chemotherapy for patients with advanced, recurrent or metastatic lesions. We report a case of a 39-year-old female with a history of esthesioneuroblastoma, previously treated with resection, radiation and chemotherapy, presenting with a recurrent disease that was successfully treated with re-resection and placement of Gliadel) wafers in the surgical resection cavity. The novel option of controlled-release and local delivery of a chemotherapeutic agent for treatment of recurrent esthesioneuroblastoma should be recognized and considered.
authors.affiliation: Department of Clinical Neurosciences, Program in Neurosurgery, Brown Medical School, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Park
authors.forename: Charles E
authors.initials: CE
authors.lastname: Weaver
authors.forename: John E
authors.initials: JE
authors.lastname: Donahue
authors.forename: Prakash
authors.initials: P
authors.lastname: Sampath
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000008:administration & dosage; D002330:Carmustine / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003652:Decanoic Acids / Q000008:administration & dosage; D004337:Drug Carriers / Q000008:administration & dosage; D004343:Drug Implants; D018304:Esthesioneuroblastoma, Olfactory / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011091:Polyesters / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D001672:Biocompatible Materials; D003652:Decanoic Acids; D004337:Drug Carriers; D004343:Drug Implants; D011091:Polyesters; C453779:carmustine with prolifeprosan 20; C055401:decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer; D002330:Carmustine