title: CspA regulates pigment production in Staphylococcus aureus through a SigB-dependent mechanism.
abstract: We report that the cold shock protein CspA of Staphylococcus aureus is required for maximal production of pigment. Results from transcriptional studies revealed that loss of CspA resulted in decreased expression of genes needed for the biosynthesis of 4,4'-diaponeurosporene and the alternative sigma factor SigB.
authors.affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Katzif
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Lee
authors.forename: Anthony B
authors.initials: AB
authors.lastname: Law
authors.forename: Yih-Ling
authors.initials: YL
authors.lastname: Tzeng
authors.forename: William M
authors.initials: WM
authors.lastname: Shafer
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002338:Carotenoids / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D010860:Pigments, Biological / Q000096:biosynthesis*; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism; D013211:Staphylococcus aureus / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014315:Triterpenes / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D010860:Pigments, Biological; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D014157:Transcription Factors; D014315:Triterpenes; C062260:cold shock protein CS7.4, Bacteria; D002338:Carotenoids; C091058:4,4'-diaponeurosporene