Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.
Danshen, the dried root of Salvia miltiorrhiza, has been widely used in China and, to a lesser extent, in Japan, the United States, and other European countries for the treatment of cardiovascular and cerebrovascular diseases. In China, the specific clinical use is angina pectoris, hyperlipidemia, and acute ischemic stroke. The current review covers its traditional uses, chemical constituents, pharmacological activities, pharmacokinetics, clinical applications, and potential herb-drug interactions based on information obtained in both the English and Chinese literature. Although numerous clinical trials have demonstrated that certain Danshen products in China are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its mechanism of actions will be necessary to ensure the safety, effectiveness, and better understanding of its action.
Zhou
Limin
L
Faculty of Medicine, School of Pharmacy and Drug Development Centre, Chinese University of Hong Kong, Shatin, N.T. Hong Kong, PR China.
Zuo
Zhong
Z
Chow
Moses Sing Sum
MS
D045784:Abietanes; D000787:Angina Pectoris / Q000188:drug therapy; D000818:Animals; D001572:Benzofurans / Q000493:pharmacokinetics / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D041743:Herb-Drug Interactions; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy; D007773:Lactates / Q000493:pharmacokinetics / Q000494:pharmacology; D010616:Phenanthrenes / Q000493:pharmacokinetics / Q000494:pharmacology; D010618:Phenanthrolines / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts; D016032:Randomized Controlled Trials as Topic; D027561:Salvia miltiorrhiza; D020521:Stroke / Q000188:drug therapy; D053630:Depsides
D045784:Abietanes; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D007773:Lactates; D010616:Phenanthrenes; D010618:Phenanthrolines; D010936:Plant Extracts; C021751:tanshinone; C028972:dan-shen root extract; C035055:3,4-dihydroxyphenyllactic acid; C076944:salvianolic acid B; D053630:Depsides