Effects of conversion from cyclosporine to tacrolimus on left ventricular structure in cardiac allograft recipients.
Twelve heart transplant recipients selected for conversion from cyclosporine to tacrolimus because of adverse effects of cyclosporine therapy underwent echocardiography at baseline and 6 months after conversion. Left ventricular mass decreased by 24% and left ventricular geometry returned toward normal at 6 months after conversion, without significant changes in blood pressure.
Peura
Jennifer L
JL
Division of Cardiology, Department of Internal Medicine, Medical University of South Carolina, Gazes Cardiac Research Institute, Charleston 29425, USA.
Zile
Michael R
MR
Feldman
David S
DS
VanBakel
Adrian B
AB
McClure
Catherine
C
Uber
Walter
W
Haynes
Hwajoo
H
Pereira
Naveen L
NL
D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016559:Tacrolimus / Q000494:pharmacology*; D014184:Transplantation, Homologous; D020257:Ventricular Remodeling / Q000187:drug effects*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus