Effect of bupropion on sexual dysfunction.
OBJECTIVE
To determine the role of bupropion in treatment of sexual dysfunction.


METHODS
Studies and case reports were identified through MEDLINE (1970-July 2005) using search terms bupropion, antidepressants, sexual function, and sexual dysfunction.


RESULTS
Bupropion has been shown to have a favorable effect on sexual dysfunction. Several reports and small, short-term trials have examined bupropion as an adjunct or substitute for other antidepressants in sexually dysfunctional patients. Use of bupropion has also been studied in nondepressed patients. Bupropion may be a promising medication for treating sexual dysfunction. However, specific dosing is unclear.


CONCLUSIONS
While the studies reviewed here demonstrated some benefit in using bupropion to treat sexual dysfunction, limitations exist. Future studies should be conducted using larger sample sizes.
Ginzburg
Regina
R
College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY 11439, USA. ginzburr@stjohns.edu
Wong
Yvonne
Y
Fader
Jonathan S
JS
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D016642:Bupropion / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*
D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion