title: [The relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitro].
abstract: OBJECTIVE
  To study the relaxants effects of six extractions from Chinese Herbs (neferine, tetrandrine, kakonein, scutellarin, ginsenoside Rgl and ginsenoside Rb1) on the corpus cavernosum tissue of rabbit in vitro.
  
  
  METHODS
  Isolated stripes of rabbit corpus cavernosum tissue were precontracted with 10(-5) mol/L phenylephrine (PE). Relaxation in response to cumulative doses of six extracts at (10(-8) - 10(-3)) mol/L was determined.
  
  
  RESULTS
  On rabbit cavernosal muscle stripes precontracted with PE, neferine, tetrandrine, kakonein and scutellarin showed dose dependent relaxation. IC50 values were 4.60 x 10(-6), 3.73 x 10(-5), 8.03 x 10(-4) and 3.33 x 10(-3) mol/L, respectively. However, in the meantime, it was found that the relaxant effects of ginsenoside Rgl and ginsenoside Rbl less significant to stripes precontracted with PE. When the final concentration was 10(-3) mol/L, the relaxations were only (16.32 +/- 5.45)% and (11.21 +/- 3.10)%.
  
  
  CONCLUSIONS
  Among the six extracts which showed relaxant effects to rabbit cavernosal muscle stripes precontracted with PE, neferine had greater functions than the other five extracts.
authors.affiliation: Department of Urology, Tongji Hospital, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Ji-hong
authors.initials: JH
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Shao-gang
authors.initials: SG
authors.lastname: Wang
authors.forename: Chun-ping
authors.initials: CP
authors.lastname: Yin
authors.forename: Heng-jun
authors.initials: HJ
authors.lastname: Xiao
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Chen
authors.forename: Zhang-qun
authors.initials: ZQ
authors.lastname: Ye
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010413:Penis / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits
chemical_list: D004365:Drugs, Chinese Herbal