title: Chemoprevention: a primary cancer prevention strategy.
abstract: OBJECTIVE
  To review cancer chemoprevention clinical trials, and to discuss associated roles, responsibilities, and challenges for nursing.
  
  
  METHODS
  Journal articles, textbooks, and government reports.
  
  
  CONCLUSIONS
  Chemoprevention offers a promising approach to primary cancer prevention for a variety of organ systems. Candidate agents are rigorously evaluated for safety and efficacy through the chemoprevention clinical trials process.
  
  
  CONCLUSIONS
  Chemoprevention is an emerging discipline in which complex clinical trials are being conducted. Nurses play key roles in planning, coordinating, and implementing these studies.
authors.affiliation: Department of Helth and Human Services, National Institutes of Health, National Cancer Institute, Division of Cancer Prevention, Bethesda, MD, USA. judiths@mail.nih.gov
authors.forename: Judith J
authors.initials: JJ
authors.lastname: Smith
authors.forename: Patricia
authors.initials: P
authors.lastname: Tully
authors.forename: Rose Mary
authors.initials: RM
authors.lastname: Padberg
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018890:Chemoprevention / Q000592:standards* / Q000639:trends; D015400:Clinical Nursing Research; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000451:nursing* / Q000517:prevention & control*; D009859:Oncology Nursing; D011322:Primary Prevention / Q000458:organization & administration*; D011379:Prognosis; D018570:Risk Assessment; D016019:Survival Analysis; D014481:United States