A role for Kaiso-p120ctn complexes in cancer?
Kaiso belongs to the zinc finger and broad-complex, tramtrack and bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein family that has been implicated in tumorigenesis. Kaiso was first discovered in a complex with the armadillo-domain protein p120ctn and later shown to function as a transcriptional repressor. As p120ctn seems to relieve Kaiso-mediated repression, its altered intracellular localization in some cancer cells might result in aberrant Kaiso nuclear activity. Intriguingly, Kaiso's target genes include both methylated and sequence-specific recognition sites. The latter include genes that are modulated by the canonical Wnt (beta-catenin-T-cell factor) signalling pathway. Further interest in Kaiso stems from findings that its cytoplasmic versus nuclear localization is modulated by complex cues from the microenvironment.
van Roy
Frans M
FM
Molecular Cell Biology Unit, Department for Molecular Biomedical Research, VIB-Ghent University, Technologiepark 927, B-9052 Ghent, Belgium. F.Vanroy@dmbr.ugent.be
McCrea
Pierre D
PD
D000818:Animals; D051186:Armadillo Domain Proteins / Q000235:genetics; D051177:Catenins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D010750:Phosphoproteins; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014981:Xenopus; D029867:Xenopus Proteins / Q000235:genetics; D051176:beta Catenin / Q000235:genetics; D000095002:Delta Catenin
D051186:Armadillo Domain Proteins; D051177:Catenins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D010750:Phosphoproteins; D012097:Repressor Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C451401:ZBTB33 protein, Xenopus; C492254:ZBTB33 protein, human; D051176:beta Catenin; D000095002:Delta Catenin