title: Skeleton-selective fluorescent chemosensor based on cyclodextrin bearing a 4-amino-7-nitrobenz-2-oxa-1,3-diazole moiety.
abstract: A new type of fluorescent chemosensor, based on modified cyclodextrins bearing the fluorophore unit NBD-amine, was prepared. One of these new chemosensors, NC0betaCD, is sensitive to adamantane and borneol derivatives, which have a comparatively spherical shape that fits the beta-CD cavity, but is not sensitive to bile acids, which are strongly bound by the native beta-CD. Even in the presence of a bile acid, NC0betaCD can detect 1-adamantanol. Another of this new type of chemosensors, NC0gammaCD, is sensitive to bile acids but not to adamantane derivatives. The response of the new type of chemosensors to a guest was an increase in the fluorescence intensity.
authors.affiliation: Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B44 Nagatsuta-cho, Midori-ku, Yokohama, 226-8501. Japan. hikeda@bio.titech.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Takuya
authors.initials: T
authors.lastname: Murayama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ueno
mesh_terms: D000218:Adamantane / Q000032:analysis; D001393:Azoles / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000032:analysis*; D003505:Cyclodextrins / Q000138:chemical synthesis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D009578:Nitrobenzenes / Q000737:chemistry*
chemical_list: C507677:4-amino-7-nitrobenz-2-oxa-1,3-diazole; D001393:Azoles; D001647:Bile Acids and Salts; D003505:Cyclodextrins; D005456:Fluorescent Dyes; D009578:Nitrobenzenes; D000218:Adamantane