[I/D-polymorphism of ACE gene, morphofunctional heart condition and blood pressure 24-h profile in young men with arterial hypertension].
OBJECTIVE
To study the effects of ACE gene polymorphism on morphofunctional condition of the heart and 24-h blood pressure profile (BPP) in young men with hypertension.


METHODS
A total of 174 young and middle-aged hypertensive men (mean age 32 +/- 4.6 years and 48 +/- 3.1 years, respectively) were examined (echocardiography, 24-h BP monitoring, tests for I/D-polymorphism of ACE gene).


RESULTS
Genotype ID appeared most prevalent both in the young and middle-aged examinees (56 and 49%, respectively). Interventricular septal thickness and left ventricular myocardial mass were the largest in young hypertensive patients carrying genotype DD. Mean 24-h and nocturnal diastolic BP was significantly higher in young hypertensive patients with genotype II vs middle-aged patients with the same genotype. Carriers of genotype II had maximal variability of systolic and pulse blood pressure.


CONCLUSIONS
Genotype DD appeared most unfavourable in relation to left ventricular myocardial hypertrophy. Its carriers had the thickest right ventricular myocardium, the largest mass of the left ventricle. Homozygotes by allele-I had most pronounced changes in a 24-h BP profile.
Bagmet
A D
AD
Shestopal
N S
NS
D000328:Adult; D001794:Blood Pressure / Q000235:genetics*; D002940:Circadian Rhythm; D005838:Genotype; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000473:pathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D014463:Ultrasonography
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A