Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation.
An iridoid glycoside, oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb. along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-omicron-benzoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed 63.3+/-2.0, 62.2+/-1.6, and 63.8+/-1.5% inhibition, respectively, at a concentration of 20 microg/mL.
Kim
Dong-Hyun
DH
Graduate School of Biotechnology, Kyung Hee University, Suwon, Korea.
Lee
Hyo-Jung
HJ
Oh
Young-Jun
YJ
Kim
Min-Jung
MJ
Kim
Sung-Hoon
SH
Jeong
Tae-Sook
TS
Baek
Nam-In
NI
D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D057888:Iridoid Glucosides; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D015394:Molecular Structure; D032067:Oldenlandia / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
D005960:Glucosides; D006027:Glycosides; D057888:Iridoid Glucosides; D039823:Iridoids; D008077:Lipoproteins, LDL; D010936:Plant Extracts; C432744:asperulosidic acid; C058966:geniposidic acid