title: [Problems of prophylaxis and treatment of infectious complications in reconstructive surgery].
abstract: Infectious complications due to polyresistant staphylococci as well as strepto- and enterococci are of serious problem in reconstructive surgery, since the number of such strains isolated within 1999-2004 has amounted to 58.4-59.7% of all the isolates. Susceptibility testing of 195 isolates showed that 100% of them was susceptible to linezolid that was used in the postoperative treatment of 28 patients after reconstructive surgical operations including those with artificial circulation under conditions of a multiprofile surgical hospital. Linezolid proved to be a highly effective agent in the prophylaxis and treatment of infectious complications due to polyresistant grampositive pathogens. Step-by-step therapy with linezolid was shown possible. In the treatment of pediatric cases no side effects of linezolid were recorded.
authors.forename: N S
authors.initials: NS
authors.lastname: Bogomolova
authors.forename: T D
authors.initials: TD
authors.lastname: Oreshkina
authors.forename: L V
authors.initials: LV
authors.lastname: Bolshakov
mesh_terms: D000081:Acetamides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D019651:Plastic Surgery Procedures; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid