title: Clinicopathologic significance of gastric and intestinal phenotypic marker expression in gastric carcinomas.
abstract: BACKGROUND
  It is well known that both gastric and intestinal phenotypic cell markers are expressed in gastric cancers. This study was aimed at investigating the correlation between gastric and intestinal phenotypic marker expression patterns of tumors and the clinicopathologic characteristics of gastric carcinomas.
  
  
  METHODS
  We evaluated phenotypic marker expression by immunohistochemical staining with monoclonal antibodies. All tumors were classified as gastric (G), gastric and intestinal mixed (GI), intestinal (I), or null (N) phenotype.
  
  
  RESULTS
  The tumors were phenotypically divided into G-phenotype tumors (33.2%), GI-phenotype tumors (25.7%), I-phenotype tumors (26.8%), and N-phenotype tumors (14.3%). N-phenotype tumors were associated with more corporeal location than GI- and I-phenotype tumors (o=0.009 and p=0.007, respectively), a larger size than I-phenotype tumors (0=0.007), a higher proportion of advanced gastric cancers than G-, GI-, and I-phenotype tumors (0=0.003, p<0.001, and p<0.001, respectively), more perineural invasion than G-, GI-, and I-phenotype tumors (p=0.076, p=0.003, and p=0.003, respectively), and more lymph node metastasis than GI-phenotype tumors (p=0.017). I-phenotype tumors were associated with a higher proportion of intestinal-type tumors than G-, GI-, and N-phenotype tumors (p<0.001, p=0.011, and p<0.001, respectively).
  
  
  CONCLUSIONS
  Our results indicate that the gastric and intestinal phenotypic marker expression pattern of tumors is prognostically useful for patients with gastric carcinoma.
authors.affiliation: Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.
authors.forename: Gwang Ha
authors.initials: GH
authors.lastname: Kim
authors.forename: Geun Am
authors.initials: GA
authors.lastname: Song
authors.forename: Do Youn
authors.initials: DY
authors.lastname: Park
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Lee
authors.forename: Tae Oh
authors.initials: TO
authors.lastname: Kim
authors.forename: Seong Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Jeong
authors.initials: J
authors.lastname: Heo
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kang
authors.forename: Mong
authors.initials: M
authors.lastname: Cho
mesh_terms: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor / Q000235:genetics; D002277:Carcinoma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor