title: Mesenchymal stem cells for bone repair: preclinical studies and potential orthopedic applications.
abstract: Mesenchymal stem cells (MSCs), derived from adult bone marrow, are multi-potent stem cells capable of differentiating along several lineage pathways. From a small bone marrow aspirate, MSCs can be readily isolated and easily expanded. Therefore, MSCs are thought to be a readily available source of cells for many tissue engineering and regenerative medicine applications. This review covers preclinical models that evaluate the efficacy of MSC-loaded scaffolds in large bone defects as a potential substitute for autologous and allogeneic bone grafts. This review also covers new approaches to clinical use of MSC technology.
authors.affiliation: New Jersey Institute of Technology Biomedical Engineering, 614 East Building, University Heights, Newark, NJ 07102, USA. arinzeh@njit.edu
authors.forename: Treena Livingston
authors.initials: TL
authors.lastname: Arinzeh
mesh_terms: D000328:Adult; D000818:Animals; D001847:Bone Diseases / Q000503:physiopathology / Q000601:surgery*; D001861:Bone Regeneration / Q000502:physiology; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D019637:Orthopedic Procedures / Q000379:methods; D010012:Osteogenesis / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*