title: Low-grade fibromyxoid sarcoma arising in the big toe.
abstract: Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor. Reported herein is a case of LGFMS arising in the big toe. The patient was a 58-year-old man who underwent excision of the tumor. The tumor was well-demarcated. Histologically, there were proliferating spindle-shaped tumor cells arranged in a whorled growth pattern, and the stroma showed hyalinized collagen bundles and a myxoid matrix. Nuclear mitotic figures were conspicuous in part. A large rosette-like structure with hyalinized stroma was found, which is characteristic of LGFMS. The differential diagnosis included tumor occurrence in adults; tending to arise in distal extremities; and having bland fibromyxoid histological features, such as fibroma of tendon sheath, low-grade myxofibrosarcoma and acral myxoinflammatory fibroblastic sarcoma. It was not possible to detect the FUS/CREB3L2 and FUS/CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. LGFMS may become more common with time, and unique cases may accumulate.
authors.affiliation: Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan. kusumito@cc.hirosaki-u.ac.jp
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kusumi
authors.forename: Shinji
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Tanaka
authors.forename: Taro
authors.initials: T
authors.lastname: Ogawa
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Jin
authors.forename: Fuyuki
authors.initials: F
authors.lastname: Sato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Toh
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
mesh_terms: D003937:Diagnosis, Differential; D005350:Fibroma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014034:Toes / Q000473:pathology