title: Miniaturized ultrasound arrays for interstitial ablation and imaging.
abstract: A potential alternative to extracorporeal, noninvasive HIFU therapy is minimally invasive intense ultrasound ablation that can be performed laparoscopically or percutaneously. An approach to minimally invasive ablation of soft tissue using miniaturized linear ultrasound arrays is presented here. Recently developed 32-element arrays with aperture 2.3 x 49 mm, therapy frequency 3.1 MHz, pulse-echo bandwidths >42% and surface acoustic energy density >80 W/cm2, are described. These arrays are integrated into a probe assembly, including a coupling balloon and piercing tip, suitable for interstitial ablation. An integrated electronic control system allows therapy planning and automated treatment guided by real-time interstitial B-scan imaging. Image quality, challenging because of limited probe dimensions and channel count, is aided by signal processing techniques that improve image definition and contrast, resulting in image quality comparable to typical transabdominal ultrasound imaging. Ablation results from ex vivo and in vivo experiments on mammalian liver tissue show that this approach is capable of ablation rates and volumes relevant to clinical applications of soft tissue ablation such as treatment of liver cancer.
authors.affiliation: Ethicon Endo-Surgery, Cincinnati, OH, USA. i.makin@guidedtherapy.com
authors.forename: Inder Raj S
authors.initials: IR
authors.lastname: Makin
authors.forename: T Douglas
authors.initials: TD
authors.lastname: Mast
authors.forename: Waseem
authors.initials: W
authors.lastname: Faidi
authors.forename: Megan M
authors.initials: MM
authors.lastname: Runk
authors.forename: Peter G
authors.initials: PG
authors.lastname: Barthe
authors.forename: Michael H
authors.initials: MH
authors.lastname: Slayton
mesh_terms: D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008904:Miniaturization; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods