Locations of mouse DNA damage response and repair loci, and cancer risk modifiers.
An outline is presented of an electronically accessible database that compares the locations of mouse genes involved in DNA repair, apoptosis, cell cycle and signal transduction with those of known cancer risk modifier genes. The database has a primary but not exclusive focus on modifiers of ionizing radiation (IR) cancer risk and genes involved in IR-induced DNA damage responses. The database () provides a useful tool for assessing the role of DNA damage response genes in cancer predisposition.
Bulman
Robert A
RA
Radiation Effects Department, Health Protection Agency-Radiation Protection Division, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot OX11 0RQ, UK. Robert.Bulman@hpa-rp.org.uk
Dragani
Tommaso A
TA
Bouffler
Simon D
SD
Cox
Roger
R
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D019295:Computational Biology / Q000379:methods; D004249:DNA Damage; D004260:DNA Repair; D030541:Databases, Genetic; D015894:Genome, Human; D006801:Humans; D020407:Internet; D051379:Mice; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D011839:Radiation, Ionizing; D012306:Risk; D015398:Signal Transduction