title: [Radiation-induced sarcomas after breast cancer: experience of Institute Curie and review of literature].
abstract: Adjuvant radiotherapy to the breast plays a significant role in preventing local failure in women treated for early stage breast cancer. This fact is supported by multiple clinical trials demonstrating that adjuvant radiotherapy decreases the risk of local recurrence and increases the rate of breast preservation, and actually the rules of adjuvant breast irradiation are clearly established. Sarcomas are a rare but recognized complication of radiation therapy for breast carcinoma, and are associated with poor prognosis. The first case of a bone sarcoma after radiation therapy of breast cancer was described by Beck in 1922. In 1948, Cahan et al. defined the criteria for diagnosis of radiation-induced sarcoma. Since then, some studies have reported the incidence of radiation-induced sarcoma after radiotherapy for different cancers. This article reports and discusses the incidence, management and treatment outcome of radiation-induced sarcomas occurring after radiotherapy for breast cancer in our institute. The incidence, histology, latency of appearance, genesis, their treatment and the prognostic factors of these rare tumors are discussed and the literature is reviewed.
authors.affiliation: Département de Radiothérapie, Institut Curie, 26, rue d'Ulm, 75005 Paris, France. youlia.kirova@curie.net
authors.forename: Y
authors.initials: Y
authors.lastname: Kirova
authors.forename: J R
authors.initials: JR
authors.lastname: Vilcoq
authors.forename: B
authors.initials: B
authors.lastname: Asselain
authors.forename: X
authors.initials: X
authors.lastname: Sastre-Garau
authors.forename: F
authors.initials: F
authors.lastname: Campana
authors.forename: R
authors.initials: R
authors.lastname: Dendale
authors.forename: M
authors.initials: M
authors.lastname: Bollet
authors.forename: A
authors.initials: A
authors.lastname: Fourquet
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D012189:Retrospective Studies; D012509:Sarcoma / Q000453:epidemiology* / Q000209:etiology*