Na+ dependence of phenacetin absorption.
Phenacetin in solution at different concentrations of Na+ was orally administered to dogs. Phenacetin absorption is increased by the Na+: a positive correlation was noted between the Na+ concentration in the medium and the plasma levels of phenacetin. Ouabain antagonizes the effect of Na+ on phenacetin absorption.
Moro
E
E
Department of Nutritional Physiology, Medical School of the University of Milan.
Guiso
R
R
Cantone
A
A
D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D007408:Intestinal Absorption / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology; D010615:Phenacetin / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D012964:Sodium / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D010042:Ouabain; D012964:Sodium; D010615:Phenacetin