title: Resorption of apatite-wollastonite containing glass-ceramic and beta-tricalcium phosphate in vivo.
abstract: Apatite-wollastonite containing glass ceramic is considered to be difficult to resorb, but we experienced the disappearance of the porous type of Apatite-wollastonite glass ceramic particles . In this study, the resorption of porous apatite-wollastonite glass-ceramic implanted in the femurs of rabbits was investigated, and the process was compared with beta-tricalcium phosphate, a resorbable ceramics. Porous apatite-wollastonite glass-ceramic (70, 80, and 90% porosity) and beta-tricalcium phosphate (75% porosity) were implanted in the femurs of Japanese white rabbits. Samples were harvested and examined 0, 4, 8, 12, 24 and 36 weeks after implantation. Quantitative analysis of the radiographic and histologic findings was performed with NIH Image software. Radiographic examination demonstrated that the radiopacity and size of the porous apatite-wollastonite glassceramic cylinders decreased gradually after implantation. Histologic examination revealed that the surface area of the apatite-wollastonite glass-ceramic cylinders decreased continuously, and approached 20% of the original area 36 weeks after implantation. However, the resorption rate of porous apatite-wollastonite glass-ceramic was slower than that of beta-tricalcium phosphate. Toluidine blue staining showed abundant new bone formation on the surface of the apatite-wollastonite glassceramic matrix. Considering its mechanical strength, gradual resorption characteristics, and good osteochonductive activity, porous apatite-wollastonite glass-ceramic appears to be a suitable artificial bone substitutes.
authors.affiliation: Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. tera@yd5.so-net.ne.jp
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Teramoto
authors.forename: Akira
authors.initials: A
authors.lastname: Kawai
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Sugihara
authors.forename: Aki
authors.initials: A
authors.lastname: Yoshida
authors.forename: Hajime
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000042:Absorption; D000818:Animals; D001031:Apatites / Q000378:metabolism*; D001187:Artificial Organs; D001672:Biocompatible Materials / Q000378:metabolism*; D001843:Bone Cements / Q000378:metabolism; D001842:Bone and Bones / Q000473:pathology; D002130:Calcium Phosphates / Q000378:metabolism*; D002516:Ceramics / Q000378:metabolism*; D005269:Femur; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D016062:Porosity; D011817:Rabbits; D012824:Silicic Acid / Q000378:metabolism*
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; C077777:apatite-wollastonite-containing glass ceramic; C485817:beta-tricalcium phosphate; D012824:Silicic Acid