Bacterial enzymes that can deglycate glucose- and fructose-modified lysine.
Deglycating enzymes, i.e. enzymes that reverse the initial stage of the Maillard reaction between glucose and primary amines, are known to occur in mammalian, fungal and other eukaryotic and prokaryotic cells. In this issue of Biochemical Journal, Wiame et al. now report the existence of bacterial enzymes and an operon that control the metabolism and deglycation of glucoselysine 6-phosphate, i.e. the phosphorylated condensation product of fructose and epsilon-aminolysine. The discovery has broad implications for bacterial metabolism and possibly for the repair of protein damage by fructose.
Monnier
Vincent M
VM
Institute of Pathology and Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA. vmm3@cwru.edu
D001419:Bacteria / Q000201:enzymology* / Q000235:genetics; D005632:Fructose / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006031:Glycosylation; D008239:Lysine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*
D005632:Fructose; D005947:Glucose; D008239:Lysine