[A case of drug-induced pneumonia possibly associated with simvastatin].
A 59-year-old woman was admitted because of general fatigue, cough and progressive dyspnea about 5 months after treatment with simvastatin for hyperlipidemia. A chest radiograph and computed tomography scans revealed ground glass and reticular opacities in the right middle and lower lung fields. The percentage of peripheral blood eosinophils was elevated. After simvastatin was discontinued and administration of prednisolone was started, eosinophilia and reticular shadows improved. Drug lymphocyte stimulation test (DLST) for simvastatin was positive, so we diagnosed drug induced eosinophilic pneumonia. Now hyperlipidemia is treated frequently with HMG-CoA reductase inhibitor, but there are few reports demonstrating lung injury by this drug. We should be aware of lung side effects of HMG-CoA reductase inhibitor.
Yoshioka
Sumako
S
Second Department of Internal Medicine, Nagasaki University School of Medicine.
Mukae
Hiroshi
H
Ishii
Hiroshi
H
Nakayama
Seiko
S
Hisatomi
Keiko
K
Ishimoto
Hiroshi
H
Kakugawa
Tomoyuki
T
Sugiyama
Kanako
K
Ide
Mioko
M
Kohno
Shigeru
S
D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D006949:Hyperlipidemias / Q000188:drug therapy; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008875:Middle Aged; D013902:Radiography, Thoracic; D019821:Simvastatin / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin