title: Common ancestry of herpesviruses and tailed DNA bacteriophages.
abstract: Comparative analysis of capsid protein structures in the eukaryote-infecting herpesviruses (Herpesviridae) and the prokaryote-infecting tailed DNA bacteriophages (Caudovirales) revealed a characteristic fold that is restricted to these two virus lineages and is indicative of common ancestry. This fold not only serves as a major architectural element in capsid stability but also enables the conformational flexibility observed during viral assembly and maturation. On the basis of this and other emerging relationships, it seems increasingly likely that the very diverse collection of extant viruses may have arisen from a relatively small number of primordial progenitors.
authors.affiliation: National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Baker
authors.forename: Wen
authors.initials: W
authors.lastname: Jiang
authors.forename: Frazer J
authors.initials: FJ
authors.lastname: Rixon
authors.forename: Wah
authors.initials: W
authors.lastname: Chiu
mesh_terms: D002213:Capsid / Q000737:chemistry* / Q000648:ultrastructure; D017899:Caudovirales / Q000145:classification / Q000235:genetics* / Q000502:physiology / Q000648:ultrastructure; D016679:Genome, Viral; D006564:Herpesviridae / Q000145:classification / Q000235:genetics* / Q000502:physiology / Q000648:ultrastructure; D017510:Protein Folding