The role of lipid rafts in the pathogenesis of bacterial infections.
Numerous pathogens have evolved mechanisms of co-opting normal host endocytic machinery as a means of invading host cells. While numerous pathogens have been known to enter cells via traditional clathrin-coated pit endocytosis, a growing number of viral and bacterial pathogens have been recognized to invade host cells via clustered lipid rafts. This review focuses on several bacterial pathogens that have evolved several different mechanisms of co-opting clustered lipid rafts to invade host cells. Although these bacteria have diverse clinical presentations and many differences in their pathogenesis, they each depend on the integrity of clustered lipid rafts for their intracellular survival. Bacterial invasion via clustered lipid rafts has been recognized as an important virulence factor for a growing number of bacterial pathogens in their battle against host defenses.
Zaas
David W
DW
Duke University Medical Center, Box 3221, Jones Building Room 255, Research Drive, Durham, NC 27710, USA. david.zaas@duke.edu
Duncan
Matthew
M
Rae Wright
Jo
J
Abraham
Soman N
SN
D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism* / Q000382:microbiology; D021941:Caveolae / Q000378:metabolism / Q000382:microbiology; D051242:Caveolin 1 / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism* / Q000382:microbiology; D009161:Mycobacterium / Q000502:physiology*
D051242:Caveolin 1