Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic dissemination.
We report here invasin-dependent and invasin-independent mechanisms in which the enteropathogen Yersinia enterocolitica is able to disseminate from the lumen of the small intestine to the spleen. The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes.
Handley
Scott A
SA
Washington University School of Medicine, Department of Molecular Microbiology, 660 S. Euclid Ave., Campus Box 8230, St. Louis, MO, 63110, USA.
Newberry
Rodney D
RD
Miller
Virginia L
VL
D018829:Adhesins, Bacterial / Q000378:metabolism*; D000818:Animals; D007109:Immunity / Q000235:genetics; D007421:Intestine, Small / Q000382:microbiology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008817:Mice, Mutant Strains; D010581:Peyer's Patches / Q000276:immunology / Q000382:microbiology; D013154:Spleen / Q000382:microbiology; D015009:Yersinia Infections / Q000276:immunology / Q000382:microbiology*; D015008:Yersinia enterocolitica / Q000378:metabolism / Q000472:pathogenicity*
D018829:Adhesins, Bacterial; C053476:invasin, Yersinia