title: Intracranial nasal natural killer/T-cell lymphoma: immunopathologically-confirmed case and review of literature.
abstract: Advances in immunophenotypic profiling now permit characterization of natural killer/T-cell (NK/T-cell) lymphoma as distinct from other extranodal T- and B-cell Non-Hodgkin's lymphomas. NK/T-cell lymphoma presents most commonly in the nasal cavity. Disease progression to the central nervous system (CNS) is a rare phenomenon. We present here, to our knowledge, the first immunophenotypically-confirmed case of direct extension of nasal NK/T-cell lymphoma to the brain. In addition, we review the literature with respect to NK/T-cell lymphoma metastasis to the CNS. The overall prevalence of NK/T-cell lymphoma CNS metastasis is less than 3%. Although rare, CNS invasion portends a poor prognosis, emphasizing the importance of early and accurate immunophenotype profiling and the need for novel, aggressive therapy.
authors.affiliation: Department of Neurological Surgery, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Neal
authors.initials: N
authors.lastname: Luther
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Greenfield
authors.forename: Amy
authors.initials: A
authors.lastname: Chadburn
authors.forename: Theodore H
authors.initials: TH
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017252:CD3 Complex / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D019002:CD56 Antigen / Q000276:immunology; D003399:Craniotomy; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000276:immunology* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009669:Nose Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D017252:CD3 Complex; D015704:CD4 Antigens; D019002:CD56 Antigen