Anaphylaxis to aprotinin in fibrin sealant.
A 50-year-old man with chronic otitis media was admitted to our hospital for investigation of lung cancer. He had received repeated instillations of fibrin sealant (Bolheal) in myringoplasty 7 times over 12 months. During the lower lobectomy, soon after fibrin sealant was applied to seal bronchopleural fistulas, systolic blood pressure decreased to 60 mmHg. Treatment with epinephrine and dopamine was required until his condition improved 2 days later. The specific IgE antibody was detected for the solution for fibrinogen and factor XIII containing bovine aprotinin. Cross-reactivity between purified aprotinin and the solution was noted by competitive ELISA inhibition tests.
Shirai
Toshihiro
T
Department of Internal Medicine, Fujinomiya City General Hospital.
Shimota
Hiroshi
H
Chida
Kingo
K
Sano
Shinichi
S
Takeuchi
Yasuo
Y
Yasueda
Hiroshi
H
D000707:Anaphylaxis / Q000139:chemically induced*; D007611:Aprotinin / Q000009:adverse effects*; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008297:Male; D008875:Middle Aged
D015718:Fibrin Tissue Adhesive; D007611:Aprotinin