In vitro and in vivo observations on the erythrocyte uptake of 17-monochloroacetylajmaline.
The in vitro and in vivo observations on the uptake rate of 17-monochloroacetylajmaline by human erythrocytes showed that about 30-35% of the drug is bound to red blood cells. These findings suggest a peculiar affinity of the drug for the erythrocytes, may be for the membrane or stromal phospholipids.
Lampertico
M
M
General Hospital, Medical Division, Saronno.
Curri
S B
SB
Bombardelli
E
E
Forni
G
G
Martinelli
E M
EM
Cucurullo
V
V
D000293:Adolescent; D000328:Adult; D000404:Ajmaline / Q000031:analogs & derivatives* / Q000097:blood; D002855:Chromatography, Thin Layer; D004912:Erythrocytes / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008875:Middle Aged
D000404:Ajmaline; C008541:17-monochloroacetylajmaline