title: AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.
abstract: An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.
authors.affiliation: Laboratory of Genomic Diversity, NCI-Frederick, Basic Research Program, SAIC Frederick, P.O. Box B, Frederick, Maryland 21702, USA.
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Gao
authors.forename: Arman
authors.initials: A
authors.lastname: Bashirova
authors.forename: Astrid K N
authors.initials: AK
authors.lastname: Iversen
authors.forename: John
authors.initials: J
authors.lastname: Phair
authors.forename: James J
authors.initials: JJ
authors.lastname: Goedert
authors.forename: Susan
authors.initials: S
authors.lastname: Buchbinder
authors.forename: Keith
authors.initials: K
authors.lastname: Hoots
authors.forename: David
authors.initials: D
authors.lastname: Vlahov
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'Brien
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000276:immunology*; D000483:Alleles; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018450:Disease Progression; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D015235:HLA-B Antigens