title: Synthesis and properties of aminopropyl nucleic acids.
abstract: Oligonucleotides that contain up to three aminopropyl nucleoside analogues have been synthesized. Dimers of aminopropyl adenine and thymidine were prepared and used as building blocks by applying phosphoramidite chemistry. Both R and S isomers of the aminopropyl nucleosides were used. This incorporation led to a reduction of thermal stability of double-stranded DNA. Furthermore, the (R)-adenine analogue, which yielded (S)-APNA, can be considered as a candidate for universal base pairing.
authors.affiliation: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
authors.forename: Ding
authors.initials: D
authors.lastname: Zhou
authors.forename: Irene M
authors.initials: IM
authors.lastname: Lagoja
authors.forename: Jef
authors.initials: J
authors.lastname: Rozenski
authors.forename: Roger
authors.initials: R
authors.lastname: Busson
authors.forename: Arthur
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000225:Adenine; D000577:Amides; D000588:Amines / Q000737:chemistry*; D020029:Base Pairing; D009691:Nucleic Acid Denaturation; D009705:Nucleosides / Q000138:chemical synthesis; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010756:Phosphoric Acids; D013696:Temperature; D013941:Thymine
chemical_list: D000577:Amides; D000588:Amines; D009705:Nucleosides; D009841:Oligonucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid; D000225:Adenine; D013941:Thymine