title: [Genetic alterations and chemoresistance].
abstract: Molecular targeting agents will likely play an increasing role in the management of cancer.However, resistance to anti-neoplastic drugs remains a serious obstacle to successful cancer treatment. Analysis of SNPs and microarray technologies should enable us to predict toxic responses and sensitivities to anticancer agents of each patient, and the prediction may permit patient-specific anticancer agents and dosages that reduce the risk of acute toxicity and emergence of drug-resistant tumors. The relationships are reviewed between the chemoresistance(chemosensitivity) and polymorphisms, tumor gene expression profiles or mutations of targeted molecules that confer resistance to molecular target therapy.
authors.affiliation: Dept. of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Akiyama
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001549:Benzamides; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D000077156:Gefitinib; D020869:Gene Expression Profiling; D006801:Humans; D000068877:Imatinib Mesylate; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010597:Pharmacogenetics; D010879:Piperazines / Q000494:pharmacology; D011110:Polymorphism, Genetic; D011743:Pyrimidines / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology; D013940:Thymidylate Synthase / Q000235:genetics; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics
chemical_list: D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D011799:Quinazolines; D000068877:Imatinib Mesylate; D042943:Dihydrouracil Dehydrogenase (NADP); D013940:Thymidylate Synthase; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human; D000077156:Gefitinib