title: APOE epsilon4 is not associated with Alzheimer's disease in elderly Nigerians.
abstract: Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE epsilon4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions.
authors.affiliation: Department of Psychiatry, University of Ibadan, College of Medicine, Ibadan, Nigeria.
authors.forename: Oye
authors.initials: O
authors.lastname: Gureje
authors.forename: Adesola
authors.initials: A
authors.lastname: Ogunniyi
authors.forename: Olusegun
authors.initials: O
authors.lastname: Baiyewu
authors.forename: Brandon
authors.initials: B
authors.lastname: Price
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Unverzagt
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Evans
authors.forename: Valerie
authors.initials: V
authors.lastname: Smith-Gamble
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Lane
authors.forename: Sujuan
authors.initials: S
authors.lastname: Gao
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Hall
authors.forename: Hugh C
authors.initials: HC
authors.lastname: Hendrie
authors.forename: Jill R
authors.initials: JR
authors.lastname: Murrell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism*; D005006:Ethnicity; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008403:Mass Screening; D009549:Nigeria / Q000453:epidemiology; D020033:Protein Isoforms / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D020033:Protein Isoforms