Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project.
While efficient methods of communication are known to be essential in conducting large multicenter clinical trials, very little information is provided on actual methods that can be implemented to improve communication. An integrated technology-based communication system was developed for the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project, which prospectively defines treatments that are most effective for participants with a diagnosis of a nonpsychotic major depressive disorder (MDD) who report an unsatisfactory clinical outcome to an initial and, if necessary, subsequent treatment(s). This web-based communication system is comprised of a multi-faceted study Web site, including a help desk, document sharing, a project directory and reports. In addition, automated reporting via e-mail and an online data correction mechanism are also available. The STAR*D communication system improves communication between study personnel and improves the quality of the study's data through the integration of system elements, the integration of those elements with traditional forms of communication,, by filling the gaps not addressed by those traditional methods and by reducing the staff workload burden.
Wisniewski
Stephen R
SR
Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA. wisniew@edc.pitt.edu
Eng
Heather
H
Meloro
Leslie
L
Gatt
Robert
R
Ritz
Louise
L
Stegman
Diane
D
Trivedi
Madhukar
M
Biggs
Melanie M
MM
Friedman
Edward
E
Shores-Wilson
Kathy
K
Warden
Diane
D
Bartolowits
Douglas
D
Martin
Jeffrey P
JP
Rush
A John
AJ
D002986:Clinical Trials as Topic; D003142:Communication; D003865:Major Depressive Disorder / Q000628:therapy*; D034742:Electronic Mail; D006801:Humans; D020407:Internet; D015337:Multicenter Studies as Topic