Applications of biomimetic systems in drug delivery.
This review article highlights recent activities in the field of biomimetic systems and their application in controlled drug delivery. A definition and overview of biomimetic processes is given, with a focus on synthesis and assembly for the creation of novel biomaterials. In particular, systems are classified on the basis of three subsets, which include biological, biohybrid and synthetic structures. Examples focus on the current and proposed clinical significance for systems that mimic processes where the underlying molecular principles are well understood. Biomimetic materials and systems are presented as exceptional candidates for various controlled drug delivery applications and have enormous potential in medicine for the treatment of disease.
Venkatesh
Siddarth
S
Biomedical Devices and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn University, Auburn, AL 36849-5127, USA.
Byrne
Mark E
ME
Peppas
Nicholas A
NA
Hilt
J Zach
JZ
D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004247:DNA / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D020100:Hydrogels; D049329:Nanostructures; D009690:Nucleic Acid Conformation; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D012313:RNA / Q000737:chemistry
D003692:Delayed-Action Preparations; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D011108:Polymers; D011506:Proteins; D012313:RNA; D004247:DNA