Copy number of DAZ genes in infertile men.
The aim of the study was to define the relevance of deletions and duplications within the DAZ gene cluster to male factor infertility in a population of 90 infertile men and a control of 50 fertile men using real-time polymerase chain reaction (PCR). We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure.
Writzl
Karin
K
Division of Medical Genetics, University Medical Center, Ljubljana, Slovenia.
Zorn
Branko
B
Peterlin
Borut
B
D041322:Chromosomes, Human, Y / Q000235:genetics; D000075364:Deleted in Azoospermia 1 Protein; D017353:Gene Deletion; D018628:Gene Dosage / Q000235:genetics*; D020440:Gene Duplication; D005858:Germany; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D005810:Multigene Family / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics*
C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D016601:RNA-Binding Proteins