The effect of dexamethasone on gastric mucosal changes following sialoadenectomy in rat.
In this study, dexamethasone-induced gastric lesions were studied in rats that had undergone sialoadenectomy. The ultrastructural changes developed during the study were detected by electron microscopically, while blood serum and stomach epidermal growth factor (EGF) concentrations were measured by RIA. The result of the study showed that gastric lesions were correlated with gastric mucus secretion and both serum and mucosa EGF levels. After the administration of dexamethasone, it was found that sialoadenectomy significantly (p<0.01) raised the incidence of stomach lesions (p<0.01), and a significant increase in mucus secretion was also found. Additionally, the serum and gastric mucosal EGF levels fell after sialoadenectomy when compared to normal rats. The most important gastric mucosal changes were observed in rats treated with dexamethasone and those both sialoadenectomised and treated with dexamethasone.
Elitok
B
B
Department of Internal Medicine, Afyon Kocatepe University Faculty of Veterinary Medicine, Afyon, Turkey. elitok1969@hotmail.com
Elitok
O M
OM
Ketani
M A
MA
Kurt
D
D
Kanay
Z
Z
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004815:Epidermal Growth Factor / Q000097:blood / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D009093:Mucus / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012469:Salivary Glands / Q000502:physiology* / Q000601:surgery; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D000893:Anti-Inflammatory Agents; D004815:Epidermal Growth Factor; D003907:Dexamethasone