[Effects of short-term chemotherapy on the compliance of rabbit abdominal aorta].
OBJECTIVE
To investigate the effect of short-term chemotherapy on the compliance of rabbit abdominal aorta, and understand the changes in the biomechanical properties of the blood vessels after chemotherapy.


METHODS
Fifteen rabbits were divided into 5 groups, 4 of which were subjected to injection with chemotherapeutic agents for 5 days to evaluate the compliance of the abdominal aorta at 2, 7, 14, and 21 days after the therapy with the other group without chemotherapy serving as the control.


RESULTS
The compliance of the abdominal aorta was obviously decreased after chemotherapy and reached the lowest level 14 days after short-term chemotherapy, suggesting that the drugs resulted in vascular injury enough to alter the biomechanical properties of the blood vessels.


CONCLUSIONS
Short-term chemotherapy can decrease the compliance of the blood vessels, which may deteriorate with time but such changes can be reversible.
Shen
Ce
C
Sixth Hospital of Shanghai Jiaotong University, Shanghai 200233, China.
Liu
Hao
H
Zuo
Qiang
Q
Zhang
Jun-yi
JY
Yang
Jin-xing
JX
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000494:pharmacology; D001012:Aorta, Abdominal / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology; D003187:Compliance / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D011817:Rabbits
D003520:Cyclophosphamide; D002945:Cisplatin