title: [Interstitial granulomatous dermatitis without arthritis: successful therapy with hydroxychloroquine].
abstract: Interstitial granulomatous dermatitis is a rare entity characterized by cutaneous linear strands (the "rope sign") and rheumatoid arthritis. In the past years, 12 other cases have been described with variable cutaneous symptoms. All showed similar histological features, resembling those of granuloma annulare or 'palisaded neutrophilic and granulomatous dermatitis', suggesting a wide spectrum for a single entity. A 60-year-old patient presented with erythematous patches with an indurated, violaceous border resembling the "rope sign" on both flanks. The histological investigation revealed dense diffuse interstitial inflammatory infiltrates composed of eosinophils, neutrophils, lymphocytes, macrophages and multinucleated giant cells in the superficial and deep dermis. In the deep dermis, prominent eosinophilic degenerated collagen fibres with surrounding macrophages ('floating sign') occurred. In contrast to most previously described patients, our patient did not have arthralgias. The skin findings cleared following therapy with hydroxychloroquine.
authors.affiliation: Universitäts-Hautklinik Münster.
authors.forename: Eva Kristina
authors.initials: EK
authors.lastname: Gerbing
authors.forename: Dieter
authors.initials: D
authors.lastname: Metze
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Luger
authors.forename: Sonja
authors.initials: S
authors.lastname: Ständer
mesh_terms: D001168:Arthritis / Q000150:complications; D003872:Dermatitis / Q000150:complications* / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D006886:Hydroxychloroquine