[Study on hydroxyapatite porous scaffold bonded by phosphates and its biocompatibility].
The porous scaffolds for bone tissue engineering were prepared by foam impregnation. The magnesium and aluminum acid phosphates were used as bonder and the hydroxyapatite ((Ca10 (PO4)6(OH)2, HA) powder as raw materials. Scanning electron microscopy (SEM) examination indicated that the 3D interconnected porous structure of the organic foam was replicated well by the scaffolds calcined at high temperature and the structural requirement of tissue engineering was satisfied. XRD analysis showed that the scaffold was composed of HA and Ca7Mg2P6O24 while calcined at 1150 degrees C for shorter time and of (Ca, Mg)3(PO4)2 when the time prolonged to 2 h. There was no peak of CaO found in the scaffolds by XRD. According to the culture in vitro, the scaffold possesses good biocompatibility and certain degree of degradability.
Dong
Yinsheng
Y
Department of Mechanical Engineering, Southeast University, Nanjing 210096, China. dongys@seu.edu.cn
Zhang
Qingguo
Q
Liu
Bin
B
Guo
Zongke
Z
Lin
Pinghua
P
Pu
Yuepu
Y
D017607:Aluminum Compounds / Q000737:chemistry; D001672:Biocompatible Materials; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D016062:Porosity; D023822:Tissue Engineering
D017607:Aluminum Compounds; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D010710:Phosphates; D017886:Durapatite; C012714:aluminum phosphate