Acute graft pyelonephritis: a potential cause of acute rejection in renal transplant.
Acute graft pyelonephritis is a common complication in renal transplant recipients. The consequences of this complication on kidney allograft survival remain controversial. Bacterial infection is likely to activate the immune system, potentially leading to acute or chronic rejection. Here, we report for the first time two documented cases of acute rejection occurring shortly after acute graft pyelonephritis, suggesting that pyelonephritis can initiate acute rejection. The immunologic process leading to the alloimmune response is discussed. These reports suggest that acute rejection should be questioned in case of atypical graft outcome in the context of acute graft pyelonephritis.
Audard
Vincent
V
Department of Nephrology and Transplantation, Hôpital Henri Mondor, Créteil, France.
Amor
Mounia
M
Desvaux
Dominique
D
Pastural
Myriam
M
Baron
Christophe
C
Philippe
Remy
R
Pardon
Agathe
A
Dahmane
Djamel
D
Lang
Philippe
P
Grimbert
Philippe
P
D000208:Acute Disease; D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000209:etiology* / Q000382:microbiology; D011704:Pyelonephritis / Q000150:complications* / Q000382:microbiology