Functional connectivity with the hippocampus during successful memory formation.
Although it is well established that the hippocampus is critical for episodic memory, little is known about how the hippocampus interacts with cortical regions during successful memory formation. Here, we used event-related functional magnetic resonance imaging (fMRI) to identify areas that exhibited differential functional connectivity with the hippocampus during processing of novel objects that were subsequently remembered or forgotten on a postscan test. Functional connectivity with the hippocampus was enhanced during successful, as compared with unsuccessful, memory formation, in a distributed network of limbic cortical areas-including perirhinal, orbitofrontal, and retrosplenial/posterior cingulate cortex-that are anatomically connected with the hippocampal formation. Increased connectivity was also observed in lateral temporal, medial parietal, and medial occipital cortex. These findings demonstrate that successful memory formation is associated with transient increases in cortico-hippocampal interaction.
Ranganath
Charan
C
Department of Psychology and Center for Neuroscience, University of California at Davis, Davis, CA 95616, USA. cranganath@ucdavis.edu
Heller
Aaron
A
Cohen
Michael X
MX
Brozinsky
Craig J
CJ
Rissman
Jesse
J
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology*; D003463:Cues; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology* / Q000473:pathology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D013223:Statistics as Topic; D013647:Task Performance and Analysis; D013997:Time Factors