HPV and p53 expression in dysplastic lesions and squamous carcinomas of the oral mucosa.
We studied 18 premalignant and malignant lesions of the oral mucosa, 3 dysplasias, and 15 oral squamous carcinomas with varied localizations: lips, palate, and tongue. Immunoassays for HPV were positive in 42.8% of the squamous carcinomas, without correlation with the pattern or the degree of differentiation of the lesions. P53 immuno-expression was positive in 2 of the 3 studied cases of dysplasia (66.6%) and in 13 from the 15 cases of squamous carcinomas (86.6%). The p53 immuno-positivity in both lesional categories, with a higher rate in carcinomas, indicates the fact that the p53 gene mutations can appear precocious in the oral carcinogenesis, but can not be used as malign potential prediction factor.
Simionescu
Cristiana
C
Department of Pathology, University of Medicine and Pharmacy of Craiova. csimionescu2004@lyahoo.com
Mărgăritescu
Cl
C
Georgescu
Claudia Valentina
CV
Surpăţeanu
M
M
D002454:Cell Differentiation; D006801:Humans; D009061:Mouth Mucosa / Q000473:pathology* / Q000821:virology; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D016159:Tumor Suppressor Protein p53