IGF-I, IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies.
Prospective cohort studies on breast cancer risk among premenopausal women and insulin-like growth factor I (IGF-I) concentrations have so far included only few cases, and have shown inconsistent relative risk estimates. We pooled 220 cases of breast cancer diagnosed before age 50, and 434 control subjects, from three prospective studies in New York (USA), Umeå (Northern Sweden) and Milan (Italy), and we measured IGF-I and insulin-like growth factor binding protein 3 (IGFBP-3) with common enzyme-linked immunosorbent assays. Overall, IGF-I and IGFBP-3 measurements obtained by the common method showed a positive but not significant relationship with breast cancer risk (odds ratios (ORs) 0.90 [95% confidence intervals (95% CI) 0.50-1.62], 1.63 [0.89-2.97], 1.46 [0.78-2.73] and 1.41 [0.75-2.63] for quintiles of IGF-I, and ORs 0.98 [0.54-1.75], 1.06 [0.59-1.91], 1.04 [0.58-1.87] and 1.77 [0.97-3.24] for quintiles of IGFBP-3). Our results give only moderate support for an association of blood IGF-I with breast cancer risk in young women.
Rinaldi
Sabina
S
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, Cedex 08, France.
Toniolo
Paolo
P
Muti
Paola
P
Lundin
Eva
E
Zeleniuch-Jacquotte
Anne
A
Arslan
Alan
A
Micheli
Andrea
A
Lenner
Per
P
Dossus
Laure
L
Krogh
Vittorio
V
Shore
Roy E
RE
Koenig
Karen L
KL
Riboli
Elio
E
Stattin
Pär
P
Berrino
Franco
F
Hallmans
Göran
G
Lukanova
Annekatrin
A
Kaaks
Rudolf
R
D000328:Adult; D017668:Age of Onset; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007558:Italy; D008875:Middle Aged; D009518:New York; D017697:Premenopause; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden
D014408:Biomarkers, Tumor; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I