title: Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders.
abstract: Natural killer (NK) lymphoma in Asia is frequently associated with latent Epstein-Barr (EBV) infection. Unlike the adult cases, EBV-associated NK/T cell lymphomas in children are often preceded by various EBV-related disorders, including chronic active EBV infection (CAEBV), hypersensitivity to mosquito bites (HMB), virus-associated haemophagocytic syndrome (VAHS), and hydroa vacciniforme (HV)-like eruptions. Here, we report a 14-year-old Japanese girl who sequentially developed all the symptoms related to EBV-associated NK/T cell lymphoproliferative disorders in a 12-year clinical course. Our observations confirm the spectrum of EBV-associated cutaneous disorders and indicate the importance of long-term follow-up.
authors.affiliation: Department of Dermatology, National Hospital Organization Nagoya Medical Center, Nagoya 460-0001, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nitta
authors.forename: Keiji
authors.initials: K
authors.lastname: Iwatsuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Seiji
authors.initials: S
authors.lastname: Kojima
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Morishima
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Tsuji
authors.forename: Takashi
authors.initials: T
authors.lastname: Oono
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007694:Killer Cells, Natural; D008223:Lymphoma / Q000209:etiology*