title: Intracranial pressure response to induced hypertension: role of dynamic pressure autoregulation.
abstract: OBJECTIVE
  Induced hypertension is commonly used to improve cerebral perfusion, but this treatment may have the deleterious side effect of raising intracranial pressure (ICP). We tested the hypothesis that dynamic pressure autoregulation testing could identify patients who might develop increased ICP during induced hypertension.
  
  
  METHODS
  Twenty-two studies were performed in 21 patients. Baseline dynamic testing of autoregulation by cuff deflation and carotid compression techniques was performed. After phenylephrine was infused to increase mean arterial pressure by 20 to 30 mm Hg, cuff deflation tests were repeated.
  
  
  RESULTS
  The average increase in mean arterial pressure was 32.2 +/- 16.1 mm Hg. This increase was accompanied by increased flow velocity (P < 0.001), brain tissue PO2 (P = 0.011), and regional cerebral blood flow (P = 0.008). Also, dynamic pressure autoregulation consistently improved (P = 0.015). Induced hypertension caused increased ICP (iICP) in 12 patients and a decrease in ICP (dICP) in 9. Baseline jugular venous oxygen saturation in the iICP group was 82 +/- 10% compared with 70 +/- 10% in dICP patients (P = 0.02). Baseline dynamic autoregulatory index for the cuff deflation tests (1.8 +/- 1.4) and baseline transient hyperemic response ratio for the carotid compression tests (1.11 +/- 0.07) were significantly lower in iICP patients (dICP group: autoregulatory index 3.2 +/- 1.7, P = 0.06; transient hyperemic response ratio 1.26 +/- 0.11, P = 0.009). Flow velocity increased more with the increase in blood pressure in the iICP group than in the dICP group: 19.0 +/- 6.8 cm/s versus 10.2 +/- 6.3 cm/s (P = 0.007).
  
  
  CONCLUSIONS
  The patients who had an increase in ICP with induced hypertension had a greater degree of impairment of autoregulation and induced hypertension resulted in a greater increase in flow velocity.
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA. hlatky@uthscsa.edu
authors.forename: Roman
authors.initials: R
authors.lastname: Hlatky
authors.forename: Alex B
authors.initials: AB
authors.lastname: Valadka
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Robertson
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology*; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D017711:Nonlinear Dynamics; D010100:Oxygen; D015203:Reproducibility of Results
chemical_list: D010100:Oxygen