The enigmatic role of Sir2 in aging.
In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.
Kennedy
Brian K
BK
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
Smith
Erica D
ED
Kaeberlein
Matt
M
D000426:Alcohol Dehydrogenase / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics / Q000502:physiology; D000431:Ethanol / Q000378:metabolism; D006655:Histone Deacetylases / Q000235:genetics / Q000502:physiology*; D006358:Hot Temperature; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D018384:Oxidative Stress; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology; D017346:Protein Serine-Threonine Kinases; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins / Q000235:genetics / Q000502:physiology*; D013997:Time Factors
D029701:Saccharomyces cerevisiae Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D011494:Protein Kinases; C071569:SCH9 protein kinase; D017346:Protein Serine-Threonine Kinases; C500749:target of rapamycin protein, S cerevisiae; D017868:Cyclic AMP-Dependent Protein Kinases; C087778:SIR2 protein, S cerevisiae; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases