Clinical trials in amyotrophic lateral sclerosis: the tenuous past and the promising future.
The past decade of research in amyotrophic lateral sclerosis has contributed to a greater understanding of the disease process, the development of relevant animal models, and the identification of several therapeutic approaches that may delay disease progression. Completed and ongoing clinical trials and the process of selecting drugs for clinical trials are presented.
Choudry
Rabia B
RB
Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, GRB 1256, Boston, MA 02114, USA. rchoudry@partners.org
Cudkowicz
Merit E
ME
D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis; D002986:Clinical Trials as Topic; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D005544:Forecasting; D006801:Humans; D009414:Nerve Growth Factors / Q000627:therapeutic use
D000975:Antioxidants; D018691:Excitatory Amino Acid Antagonists; D009414:Nerve Growth Factors