title: Efficacy of caspofungin against Aspergillus terreus.
abstract: We investigated the in vitro and in vivo activities of caspofungin against Aspergillus terreus. The drug increased survival and reduced tissue fungal burden in neutropenic mice. Therefore, our data support the role of caspofungin in treating systemic infections due to this emerging pathogen.
authors.affiliation: Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I-Lancisi-Salesi, Via Conca, Torrette, Ancona 60020, Italy. l.infettive@ao-umbertoprimo.marche.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Barchiesi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Spreghini
authors.forename: Alfredo
authors.initials: A
authors.lastname: Santinelli
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Stefania
authors.initials: S
authors.lastname: Fallani
authors.forename: Esther
authors.initials: E
authors.lastname: Manso
authors.forename: Eleonora
authors.initials: E
authors.lastname: Pisa
authors.forename: Daniele
authors.initials: D
authors.lastname: Giannini
authors.forename: Andrea
authors.initials: A
authors.lastname: Novelli
authors.forename: Maria I
authors.initials: MI
authors.lastname: Cassetta
authors.forename: Teresita
authors.initials: T
authors.lastname: Mazzei
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001230:Aspergillus / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D000077336:Caspofungin; D004195:Disease Models, Animal; D054714:Echinocandins; D055666:Lipopeptides; D051379:Mice; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin