Chemo-enzymatic synthesis of a trisaccharide-linked peptide aimed at improved drug-delivery.
The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.
Johnstone
Ken D
KD
School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia.
Dieckelmann
Manuela
M
Jennings
Michael P
MP
Toth
Istvan
I
Blanchfield
Joanne T
JT
D001426:Bacterial Proteins / Q000737:chemistry*; D001483:Base Sequence; D002240:Carbohydrate Sequence; D017931:DNA Primers; D004274:DNA, Recombinant; D016503:Drug Delivery Systems; D004591:Electrophoresis, Polyacrylamide Gel; D006031:Glycosylation; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases / Q000737:chemistry*; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014312:Trisaccharides / Q000008:administration & dosage / Q000737:chemistry*
D001426:Bacterial Proteins; D017931:DNA Primers; D004274:DNA, Recombinant; D010455:Peptides; D014312:Trisaccharides; C401409:LgtA protein, bacteria; D017351:N-Acetylglucosaminyltransferases