title: IGF-I, IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies.
abstract: Prospective cohort studies on breast cancer risk among premenopausal women and insulin-like growth factor I (IGF-I) concentrations have so far included only few cases, and have shown inconsistent relative risk estimates. We pooled 220 cases of breast cancer diagnosed before age 50, and 434 control subjects, from three prospective studies in New York (USA), Umeå (Northern Sweden) and Milan (Italy), and we measured IGF-I and insulin-like growth factor binding protein 3 (IGFBP-3) with common enzyme-linked immunosorbent assays. Overall, IGF-I and IGFBP-3 measurements obtained by the common method showed a positive but not significant relationship with breast cancer risk (odds ratios (ORs) 0.90 [95% confidence intervals (95% CI) 0.50-1.62], 1.63 [0.89-2.97], 1.46 [0.78-2.73] and 1.41 [0.75-2.63] for quintiles of IGF-I, and ORs 0.98 [0.54-1.75], 1.06 [0.59-1.91], 1.04 [0.58-1.87] and 1.77 [0.97-3.24] for quintiles of IGFBP-3). Our results give only moderate support for an association of blood IGF-I with breast cancer risk in young women.
authors.affiliation: International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, Cedex 08, France.
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Paolo
authors.initials: P
authors.lastname: Toniolo
authors.forename: Paola
authors.initials: P
authors.lastname: Muti
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Alan
authors.initials: A
authors.lastname: Arslan
authors.forename: Andrea
authors.initials: A
authors.lastname: Micheli
authors.forename: Per
authors.initials: P
authors.lastname: Lenner
authors.forename: Laure
authors.initials: L
authors.lastname: Dossus
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Roy E
authors.initials: RE
authors.lastname: Shore
authors.forename: Karen L
authors.initials: KL
authors.lastname: Koenig
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Franco
authors.initials: F
authors.lastname: Berrino
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
mesh_terms: D000328:Adult; D017668:Age of Onset; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007558:Italy; D008875:Middle Aged; D009518:New York; D017697:Premenopause; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden
chemical_list: D014408:Biomarkers, Tumor; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I