Impact of dose and volume on subcutaneous fibrosis.
The multifactorial genesis of radiation-induced fibrosis makes a general outline of the occurence of this late toxicity fairly unpredictable. Scientific knowledge about dose fractionation, irradiated volume, total time, conformation procedures including IMRT can help provide better treatments. Chemical and physical therapies aimed at the removal of fibrosis are still limited or under study. The system of monitoring late toxicity used by the authors is presented.
De Santis
Mario
M
Cattedra di Radioterapia, Università Cattolica delS. Cuore, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Roma, Italy. dhrtp@rm.unicatt.it
Luzi
Stefano
S
Errico
Angelo
A
Frascino
Vincenzo
V
Mangiacotti
Maria Grazia
MG
Picardi
Vincenzo
V
Morganti
Alessio G
AG
D015897:Comorbidity; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005355:Fibrosis; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D026741:Physical Therapy Modalities; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D012307:Risk Factors; D017695:Soft Tissue Injuries / Q000209:etiology* / Q000517:prevention & control