Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery.
In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery.
Hidai
Chiaki
C
Research Center for Advanced Medicine, Nihon University School of Medicine, and Aoyama Hospital, Tokyo, Japan. hidai@med.nihon-u.ac.jp
Kawana
Masatoshi
M
Habu
Kiyoshi
K
Kazama
Hiromi
H
Kawase
Yosuke
Y
Iwata
Takamitsu
T
Suzuki
Hiroshi
H
Quertermous
Thomas
T
Kokubun
Shinichiro
S
D000818:Animals; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D015815:Cell Adhesion Molecules; D018929:Cell Culture Techniques; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D008643:Mesentery / Q000098:blood supply* / Q000196:embryology; D051379:Mice; D008822:Mice, Transgenic; D008854:Microscopy, Electron; D009024:Morphogenesis; D018919:Neovascularization, Physiologic; D010641:Phenotype
D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; C491706:Edil3 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins