title: Bench-to-bedside review: antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit.
abstract: Antimicrobial resistance has emerged as one of the most important issues complicating the management of critically ill patients with infection. This is largely due to the increasing presence of pathogenic microorganisms with resistance to existing antimicrobial agents resulting in the administration of inappropriate treatment. Effective strategies for the prevention of antimicrobial resistance within intensive care units are available and should be aggressively implemented. The importance of preventing antimicrobial resistance is magnified by the limited availability of new antimicrobial drug classes for the foreseeable future.
authors.affiliation: Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, Missouri, USA. mkollef@im.wustl.edu
authors.forename: Marin H
authors.initials: MH
authors.lastname: Kollef
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003422:Critical Care; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004334:Drug Administration Schedule; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005569:Formularies as Topic; D006801:Humans; D007362:Intensive Care Units; D017410:Practice Guidelines as Topic; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents