title: The use of gas-sensor arrays to diagnose urinary tract infections.
abstract: Sensorial analysis based on the utilisation of human senses, is one of the most important and straightforward investigation methods in food and chemical analysis. An electronic nose has been used to detect in vivo Urinary Tract Infections from 45 suspected cases that were sent for analysis in a UK Health Laboratory environment. These samples were analysed by incubation in a volatile generation test tube system for 4-5 h. The volatile production patterns were then analysed using an electronic nose system with 14 conducting polymer sensors. An intelligent model consisting of an odour generation mechanism, rapid volatile delivery and recovery system, and a classifier system based on learning techniques has been considered. The implementation of an Extended Normalised Radial Basis Function network with advanced features for determining its size and parameters and the concept of fusion of multiple classifiers dedicated to specific feature parameters has been also adopted in this study. The proposed scheme achieved a very high classification rate of the testing dataset, demonstrating in this way the efficiency of the proposed scheme compared with other approaches. This study has shown the potential for early detection of microbial contaminants in urine samples using electronic nose technology.
authors.affiliation: Mechatronics Group, School of Computer Science, University of Westminster, London, UK. kodogiv@wmin.ac.uk
authors.forename: Vassilis
authors.initials: V
authors.lastname: Kodogiannis
authors.forename: Edmund
authors.initials: E
authors.lastname: Wadge
mesh_terms: D000465:Algorithms; D001424:Bacterial Infections / Q000175:diagnosis / Q000652:urine; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D003950:Diagnostic Techniques, Urological / Q000295:instrumentation*; D004581:Electronics / Q000295:instrumentation; D005740:Gases / Q000302:isolation & purification* / Q000652:urine; D006801:Humans; D016014:Linear Models; D016571:Neural Networks, Computer; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000652:urine
chemical_list: D005740:Gases