Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III).
Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and (1)H and (13)C NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.
Green
David E
DE
Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.
Ferreira
Cara L
CL
Stick
Robert V
RV
Patrick
Brian O
BO
Adam
Michael J
MJ
Orvig
Chris
C
D002241:Carbohydrates / Q000737:chemistry*; D005708:Gallium / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013057:Spectrum Analysis
D002241:Carbohydrates; D008024:Ligands; D009942:Organometallic Compounds; D011728:Pyridones; D019275:Radiopharmaceuticals; D007204:Indium; D005708:Gallium