How to manage osteoporosis in children.
Osteoporosis is increasingly being seen in young people. The primitive forms are relatively rare, but the secondary forms--particularly in long-term corticosteroid therapy--are a relevant problem given the much longer survival in chronic diseases such as cystic fibrosis, chronic renal insufficiency, leukaemia, and Duchenne muscular dystrophy. Controlled, prospective studies to evaluate the results of prevention and therapy in children are still lacking. The basis of therapy is the correct daily intake of calcium and the use of vitamin D (or active metabolites). This helps the growing skeleton to restore its equilibrium in many cases. Restraining the long-term use of corticosteroids to the minimum effective dose and shorter duration is essential. In severe cases, particularly in the presence of fractures, bisphosphonates can be remarkably effective. In some cases, such as idiopathic juvenile osteoporosis, the rule is spontaneous resolution, and the advisability of an aggressive drug therapy is discussed.
Bianchi
Maria Luisa
ML
Bone Metabolism Unit, Istituto Auxologico Italiano, IRCCS, Via L. Ariosto, 13, Milano, Italy. ml.bianchi@auxologico.it
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D001846:Bone Development / Q000187:drug effects*; D002136:Calcium, Dietary / Q000627:therapeutic use*; D002648:Child; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D002136:Calcium, Dietary; D004164:Diphosphonates; D010281:Parathyroid Hormone; D014807:Vitamin D