title: [The impact of glucose absorbed from dialysis solution on body weight gain in peritoneal dialysis treated patients].
abstract: A proportion of peritoneal dialysis (PD) patients experience substantial body weight (BW) gain with time. It is caused by fat tissue accumulation or fluid retention. It is believed that fat tissue accumulates due to caloric contribution of glucose absorbed from dialysis solution or to the mitochondrial fat regulatory uncoupling protein (UCP) gene polymorphism. This study examined BW fluctuations in 40 patients (24 females, 16 males), treated by PD at least 36 months (initial mean age 54.50+/-9.00 years, mean BW 68.00+/-8.50 kg and mean height 164.00+/-8.50 cm), relation of the BW fluctuation and caloric contribution of glucose absorbed from dialysis solution and characteristics of the patients with BW gain. Initial BW increased after 6, 12, 24 and 36 months by 5.90+/-3.50 kg, 7.90+/-4.90 kg, 9.50+/-5.00 and 11.00+/-5.00 kg, or for 8.68, 11.62, 13.97 and 16.18% of the initial value, respectively. After the first 6 and 12 months 38 patients gained weight, 39 after 24 and all 40 patients after 36 months. There was not significant correlation between BW gain and caloric contribution of glucose absorbed from dialysis solution. Female patients had initially lower BW, but for the first 12 months period significantly increased BW more than males, and not for the other observed periods. High transporters (patients with higher transport, higher transmission of glucose from peritoneal solution into the blood, and urea and creatinine in the opposite direction, with rapid decrement of osmolality gradient between dialysate and blood that is necessary for excessive fluid elimination), had lower initial BW and, although without statistical significance, only within the first period increased BW more than low transporters. In conclusion, with time BW gain was found in all the PD dialysis patients, it was not related to caloric contribution of glucose absorbed from dialysis solution, and women and high transporters increased BW weight more than men and low transporters in the first year of treatment. The BW gain is at least in part caused by fluid retention.
authors.affiliation: Klinicka bolnica Osijek, Klinika za unutarnje bolesti, Odjel za dijalizu.
authors.forename: Marko
authors.initials: M
authors.lastname: Jakić
authors.forename: Sanja
authors.initials: S
authors.lastname: Stipanić
authors.forename: Dubravka
authors.initials: D
authors.lastname: Mihaljević
authors.forename: Lada
authors.initials: L
authors.lastname: Zibar
authors.forename: Vesna
authors.initials: V
authors.lastname: Lovcić
authors.forename: Dragan
authors.initials: D
authors.lastname: Klarić
authors.forename: Marijana
authors.initials: M
authors.lastname: Jakić
mesh_terms: D002149:Energy Intake; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism*; D015312:Hemodialysis Solutions / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D015430:Weight Gain
chemical_list: D015312:Hemodialysis Solutions; D005947:Glucose