Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida.
Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five cycloartane triterpenoids isolated from the EtOAc fraction. Compounds (1,2,3) showed moderate cytotoxic activity on R-HepG2 cells and drug resistant sub line R-HepG2 but exhibited less toxicity against primary cultured normal mouse hepatocytes. Compounds (4) and (5) were inactive on all tested cell lines.
Tian
Ze
Z
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100094, PR China.
Pan
Rui Le
RL
Si
Jianyong
J
Xiao
Pei Gen
PG
D000818:Animals; D002460:Cell Line; D031885:Cimicifuga / Q000737:chemistry*; D006027:Glycosides; D022781:Hepatocytes / Q000187:drug effects*; D007810:Lanosterol / Q000031:analogs & derivatives; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C485277:cimifoetiside IV; D007810:Lanosterol; C085352:cycloartane