title: Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis.
abstract: Immunosuppressed mice were infected intravenously with conidia of Scedosporium prolificans. Treatment was begun 1 day later with liposomal amphotericin B, caspofungin, or both drugs initiated concurrently. Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone.
authors.affiliation: The University of Texas Health Science Center at San Antonio, Department of Medicine/Division of Infectious Diseases (MC 7881), 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA. Bocanegra@uthscsa.edu
authors.forename: Rosie
authors.initials: R
authors.lastname: Bocanegra
authors.forename: Laura K
authors.initials: LK
authors.lastname: Najvar
authors.forename: Steve
authors.initials: S
authors.lastname: Hernandez
authors.forename: Dora I
authors.initials: DI
authors.lastname: McCarthy
authors.forename: John R
authors.initials: JR
authors.lastname: Graybill
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077336:Caspofungin; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D054714:Echinocandins; D055666:Lipopeptides; D051379:Mice; D008271:Mycetoma / Q000188:drug therapy*; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D021681:Scedosporium
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077336:Caspofungin