Conference overview: molecular mechanisms of metal toxicity and carcinogenesis.
Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest research concerning these mechanisms. Major areas of focus included exposure assessment and biomarker identification, roles of ROS and antioxidants in carcinogenesis, mechanisms of metal-induced DNA damage, metal signalling, and the development of animal models for use in metal toxicology studies. Here we highlight some of the research presented, and summarize the conference proceedings.
Bower
Jacquelyn J
JJ
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA.
Leonard
Stephen S
SS
Shi
Xianglin
X
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001151:Arsenic / Q000633:toxicity; D001661:Biliary Tract Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D002857:Chromium / Q000633:toxicity; D003300:Copper / Q000633:toxicity; D004249:DNA Damage; D004781:Environmental Exposure; D006801:Humans; D008670:Metals / Q000633:toxicity*; D008938:Mitosis / Q000187:drug effects; D023421:Models, Animal; D009062:Mouth Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D000975:Antioxidants; D014408:Biomarkers, Tumor; D002273:Carcinogens; D008670:Metals; D017382:Reactive Oxygen Species; D002857:Chromium; C074702:chromium hexavalent ion; D003300:Copper; D001151:Arsenic