title: Changes in bone metabolism in a rat model of traumatic brain injury.
abstract: OBJECTIVE
  To evaluate the process of bone metabolism after traumatic brain injury.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Rats were randomly assigned to either the brain injury group or to the sham-operation group using a fluid percussion device. The BMDs of lumbar vertebrae and proximal femur and bone turnover markers, osteocalcin and carboxy-terminal telopeptide, were measured at three points: the day before surgery and 1 and 3 weeks post-operatively. The biomechanics (maximum load of tibia and femoral neck) were measured 3 weeks post-operatively.
  
  
  RESULTS
  There was significant change in the BMDs of lumbar vertebrae 1 week post-operatively and of both distal femurs 3 weeks post-operatively (p < 0.05). A significant change in the maximum load of femoral neck was also observed 3 weeks post-operatively between the brain injury and the sham-operation groups (p = 0.044).
  
  
  CONCLUSIONS
  This finding suggests that brain injury could induce osteoporosis by immobilization.
authors.affiliation: Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Korea.
authors.forename: Jong In
authors.initials: JI
authors.lastname: Lee
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Eun Suk
authors.initials: ES
authors.lastname: Choi
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Lim
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Ko
authors.forename: Young Min
authors.initials: YM
authors.lastname: Han
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D001930:Brain Injuries / Q000378:metabolism*; D005260:Female; D005269:Femur / Q000502:physiology; D008159:Lumbar Vertebrae / Q000502:physiology; D023421:Models, Animal; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; D010455:Peptides; D015675:Osteocalcin