Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count.
The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.
Schacker
Timothy W
TW
Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Reilly
Cavan
C
Beilman
Gregory J
GJ
Taylor
Jodie
J
Skarda
David
D
Krason
David
D
Larson
Matthew
M
Haase
Ashley T
AT
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005355:Fibrosis; D015658:HIV Infections / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*