[Rhinovirus diseases: pathogenesis, diagnostics and treatment].
Contemporary data on human rhinovirus diseases and their pathogenesis are presented. Special attention is paid to complications which may be caused by rhinovirus infections in allergy-susceptible patients. Furthermore, approaches to the diagnostics and treatment of rhinovirus diseases are described. In particular, the advantages of molecular methods for the diagnostics of rhinovirus infection (based on the PCR) in comparison with cultural and immunochemical methods are pointed out. New investigations aimed at the development of specific antirhinovirus preparations--capsid-binding (Pleconaril), blocking the binding of the virus with cell receptors (ICAM, soluble) and inhibiting rhinovirus protease 3C--have been considered.
Faĭzuloev
E B
EB
Nikonova
A A
AA
Zverev
V V
VV
D000086042:3C Viral Proteases; D000998:Antiviral Agents / Q000627:therapeutic use; D003139:Common Cold / Q000188:drug therapy; D003546:Cysteine Endopeptidases; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000627:therapeutic use; D010069:Oxadiazoles / Q000627:therapeutic use; D010080:Oxazoles; D010850:Picornaviridae Infections / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016133:Polymerase Chain Reaction; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D012367:RNA, Viral / Q000032:analysis; D012130:Respiratory Hypersensitivity / Q000209:etiology; D012229:Rhinovirus / Q000235:genetics / Q000302:isolation & purification; D012995:Solubility; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; D010069:Oxadiazoles; D010080:Oxazoles; D011480:Protease Inhibitors; D012367:RNA, Viral; D014764:Viral Proteins; D018799:Intercellular Adhesion Molecule-1; C115201:pleconaril; D003546:Cysteine Endopeptidases; D000086042:3C Viral Proteases