title: Vacuum-assisted core biopsy (Mammotome) for the diagnosis of non-palpable breast lesions: four-year experience in an Italian center.
abstract: OBJECTIVE
  Microinvasive biopsy techniques are increasingly employed in the diagnostic assessment of non-palpable breast lesions (NPBLs). This study reports the four-year experience of an Italian surgical center in the evaluation of the diagnostic effectiveness versus adverse effects of vacuum-assisted core biopsy (Mammotome).
  
  
  METHODS
  314 NPBLs with a dubious ultrasound and/or radiographic appearance were subjected to mammography-guided (86) or ultrasound-guided (228) Mammotome biopsy.
  
  
  RESULTS
  The procedure could be completed and was diagnostic in 305 cases (P < 0.0001). Adverse events were transient light-headedness. In two cases and moderate bleeding in three cases. Histological processing of the biopsies showed 227 cases of benign disease (74.42%), 68 cases of carcinoma (20 carcinomas in situ and 48 infiltrating carcinomas) (22.29%), nine cases of atypical ductal hyperplasia (2.95%) and one atypical lobular hyperplasia (0.33%). Only 12 patients reported mild discomfort relative to the procedure. The difference between the number of patients reporting discomfort and that of patients reporting no discomfort at all was highly significant (P < 0.0001).
  
  
  CONCLUSIONS
  The results confirm that Mammotome biopsy is a highly effective procedure for the diagnosis of NPBLs, with minimal negative effects.
authors.affiliation: Department of General Surgery, "G D'Annunzio" University of Chieti, Italy. r.costantini@unich.it
authors.forename: Raffaele
authors.initials: R
authors.lastname: Costantini
authors.forename: Augusto
authors.initials: A
authors.lastname: Sardellone
authors.forename: Cristiana
authors.initials: C
authors.lastname: Marino
authors.forename: Maria Adele
authors.initials: MA
authors.lastname: Giamberardino
authors.forename: Paolo
authors.initials: P
authors.lastname: Innocenti
authors.forename: Antonio Maria
authors.initials: AM
authors.lastname: Napolitano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000009:adverse effects* / Q000379:methods*; D001941:Breast Diseases / Q000175:diagnosis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002173:Cancer Care Facilities; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007558:Italy; D008327:Mammography; D008875:Middle Aged; D010173:Palpation; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016217:Ultrasonography, Mammary; D014618:Vacuum