Creatinine clearance and hemoglobin concentration before and after heart transplantation.
Clinical studies indicate that indices of glomerular filtration rate (GFR) as serum creatinine or creatinine clearance can predict the risk of death in congestive heart failure (CHF) and in heart transplantation. The study reports data on creatinine clearance before and after heart transplantation in 160 patients followed-up for 5 years at our Unit. Pre-transplant creatinine clearance averaged 83.5+/-32 mL/min x 1.73 m(2) and was not significantly associated with 5-year mortality. Creatinine clearance significantly decreased after heart transplantation with a linear trend up to 3 years for patients with complete follow-up. Data suggest that the relation between kidney function and mortality after heart transplantation is affected by several confounders with inclusion of cause of heart disease, co-morbidity, anemia, and post-transplant decrease in kidney function.
Cirillo
Massimo
M
Departments of Nephrology and Heart Surgery, Second University of Naples, Naples, Italy. massimo.cirillo@unina2.it
De Santo
Luca S
LS
Pollastro
Rosa Maria
RM
Romano
Giampaolo
G
Mastroianni
Ciro
C
Mastroiacono
Ciro
C
Maiello
Ciro
C
Amarelli
Cristiano
C
Di Stazio
Enzo
E
Perna
Alessandra
A
Anastasio
Pietro
P
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine*; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006333:Heart Failure / Q000175:diagnosis* / Q000401:mortality* / Q000652:urine; D016027:Heart Transplantation / Q000379:methods / Q000401:mortality*; D006403:Hematologic Tests; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016019:Survival Analysis
D015415:Biomarkers; D006454:Hemoglobins; D003404:Creatinine