title: Consensus development in acute renal failure: The Acute Dialysis Quality Initiative.
abstract: OBJECTIVE
  Although acute renal failure is both common and highly lethal in the intensive care unit, our understanding of the epidemiology and pathophysiology of acute renal failure is limited, and treatment for acute renal failure is extremely variable around the world. The general lack of consensus with regard to definitions, prevention, and treatment of acute renal failure has limited progress in this field.
  
  
  RESULTS
  Consensus in acute renal failure requires establishing a framework in which intensivists, nephrologists, pharmacologists, and others who care for critically ill patients with or at risk for acute renal failure can reach consensus and develop evidence-based practice guidelines. The Acute Dialysis Quality Initiative seeks to provide an objective, dispassionate distillation of the literature and description of the current state of practice of dialysis and related therapies as they are applied to acutely ill patients. The purposes of Acute Dialysis Quality Initiative are first, to develop a consensus of opinion, with evidence where possible, on best practice; and second, to articulate a research agenda to focus on important unanswered questions.
  
  
  CONCLUSIONS
  Broad consensus in the diagnosis and management of acute renal failure and in the use of blood purification in nonrenal critical illness is achievable. Standardization of definitions, practice, and research methodology is urgently needed, and specific proposals have been made by an international, interdisciplinary group.
authors.affiliation: Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. kellumja@ccm.upmc.edu
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
authors.forename: Ravindra
authors.initials: R
authors.lastname: Mehta
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D010348:Patient Care Team; D006435:Renal Dialysis / Q000592:standards*; D017582:Renal Replacement Therapy