Reactivity of Grubbs' catalysts with urea- and amide-substituted olefins. Metathesis and isomerization.
[Chemical reaction: see text] The reactions of a series of urea- and amide-substituted olefins with Grubbs' catalysts are presented. Depending on the substrate's nature, the formation of either cross-metathesis or isomerization products is observed. To favor the cross-metathesis products, the reactions have been carried out using a wide range of experimental conditions. Upon addition of monophenyl phosphoester to these reactions, the isomerization of the olefins is completely suppressed and the cross-metathesis products are obtained in up to 60% yield.
Formentín
Pilar
P
Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom.
Gimeno
Nélida
N
Steinke
Joachim H G
JH
Vilar
Ramón
R