title: Colorectal polyps: detection with dark-lumen MR colonography versus conventional colonoscopy.
abstract: OBJECTIVE
  To prospectively compare dark-lumen magnetic resonance (MR) colonography with conventional colonoscopy in the detection of colorectal polyps.
  
  
  METHODS
  Local ethical committee approval and informed consent were obtained. One hundred consecutive patients (56 men, 44 women; mean age +/- standard deviation, 67.7 years +/- 14.7; range, 25-82 years) who were referred for conventional colonoscopy from January 2003 to January 2004 underwent MR colonography and conventional colonoscopy after standard precolonoscopic bowel cleansing. Colonoscopy was performed immediately after MR colonography. For MR colonography, the colon was filled with approximately 2000 mL of tap water. Imaging was performed with a 1.5-T MR unit with patients in the prone position. A T1-weighted three-dimensional volumetric interpolated breath-hold sequence was performed before and 75 seconds after intravenous administration of 0.2 mmol gadobenate dimeglumine per kilogram of body weight. Results of MR colonography were analyzed on a per-polyp and per-patient basis. Findings at colonoscopy were used as the reference for determining accuracy, sensitivity, specificity, and positive and negative predictive values of MR colonography.
  
  
  RESULTS
  Of 100 patients recruited for study, 92 (52 men, 40 women; mean age, 61.5 years +/- 14.5; range, 25-82 years) underwent complete MR and conventional colonoscopy examinations. Forty-three of the 92 patients (47%) had normal findings at conventional colonoscopy. In the other 49 patients (53%), conventional colonoscopy depicted 107 polyps (82 adenomas, 25 hyperplastic polyps) and seven carcinomas. At per-polyp analysis, sensitivity of MR colonography in the detection of adenomatous polyps was 100% for polyps at least 10 mm in diameter and 84.2% for polyps 6-9 mm in diameter. At per-patient analysis, the accuracy of MR colonography was 93.1% (sensitivity, 89%; specificity, 96%) if detection of adenomatous polyps of all sizes was considered.
  
  
  CONCLUSIONS
  Dark-lumen MR colonography is a promising modality with high accuracy for detecting colorectal polyps larger than 5 mm in diameter.
authors.affiliation: Department of Medicine C (Gastroenterology), Hospital Ludwigshafen, Academic Teaching Hospital of Johannes-Gutenberg-University of Mainz, Bremserstrasse 79, 67063 Ludwigshafen am Rhein, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Hartmann
authors.forename: Boris
authors.initials: B
authors.lastname: Bassler
authors.forename: Dieter
authors.initials: D
authors.lastname: Schilling
authors.forename: Henning E
authors.initials: HE
authors.lastname: Adamek
authors.forename: Ralf
authors.initials: R
authors.lastname: Jakobs
authors.forename: Barbara
authors.initials: B
authors.lastname: Pfeifer
authors.forename: Axel
authors.initials: A
authors.lastname: Eickhoff
authors.forename: Christoph
authors.initials: C
authors.lastname: Zindel
authors.forename: Jürgen F
authors.initials: JF
authors.lastname: Riemann
authors.forename: Günter
authors.initials: G
authors.lastname: Layer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003111:Colonic Polyps / Q000175:diagnosis*; D003113:Colonoscopy; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine