From ultrathin capsules to biaqueous vesicles.
The layer-by-layer (LbL) adsorption of anionic polyelectrolytes (PE) and tobramycin sulfate (TbS) multilayers on zinc oxide core particles followed by the controlled core-removal process leads to the formation of ultrathin capsules, which gradually convert to biaqueous vesicles and emulsionlike systems depending on the hydrophilicity/hydrophobicity of the PE backbone, PE/TbS ratio, and Zn2+ concentration. The unique characteristics of the PE/TbS multilayer capsules result because of the formation of PE/TbS/H2O biphasic liquid systems unlike the other LbL capsular systems that form stiff PE coacervates when mixed together in water. This paper investigates the PE/TbS ultrathin capsule to biaqueous vesicle transition and its physicochemical properties.
Khopade
Ajay J
AJ
Sun Pharma Advanced Research Centre,Tandalja, Baroda 390 020, Gujarat, India. ajkhopade@sunpharma.com
Arulsudar
N
N
Khopade
Surekha A
SA
Knocke
Roy
R
Hartmann
Jürgen
J
Möhwald
Helmuth
H
D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D004573:Electrolytes / Q000737:chemistry; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D008970:Molecular Weight; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012542:Scattering, Radiation; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D013997:Time Factors; D014031:Tobramycin / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014965:X-Rays; D015032:Zinc / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry*
D001672:Biocompatible Materials; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004573:Electrolytes; D011108:Polymers; D011137:Polystyrenes; D014867:Water; D015032:Zinc; D015034:Zinc Oxide; D014031:Tobramycin