A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line.
Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.
Furutani
Takashi
T
Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Japan.
Takeyama
Ken-ichi
K
Koutoku
Hiroshi
H
Ito
Saya
S
Taniguchi
Nobuaki
N
Suzuki
Eriko
E
Kudoh
Masafumi
M
Shibasaki
Masayuki
M
Shikama
Hisataka
H
Kato
Shigeaki
S
D000728:Androgens / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008024:Ligands; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D034741:RNA, Small Interfering / Q000494:pharmacology; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology*
D000728:Androgens; D008024:Ligands; D034741:RNA, Small Interfering; D011944:Receptors, Androgen