title: Subcentimeter large cell neuroendocrine carcinoma of the lung.
abstract: To our knowledge, no report exists of a subcentimeter size large cell neuroendocrine carcinoma (LCNEC) of the lung. A 75-year-old man participating in a low-dose CT screening program for lung cancer was found incidentally to have a partly-solid nodule in the right upper lung. After treatment with antibiotics, a repeat CT showed resolution of the nodule, but a new solid nodule measuring 9 x 9 mm was detected in the left lower lobe. The lesion showed marked enhancement on dynamic contrast-enhanced MRI. Video-assisted thoracic surgery and frozen section biopsy was suggestive of malignant lesion, resulting in extension of surgery to lobectomy with nodal dissection. The final diagnosis was stage IA-LCNEC. The estimated volume doubling time of the tumor was 30.1 days. These aggressive tumors may rarely have doubling times that overlap with benign processes.
authors.affiliation: Department of Surgery, JA. Azumi General Hospital, Nagano, Japan. hanaoka-takaomi@umin.ac.jp
authors.forename: Takaomi
authors.initials: T
authors.lastname: Hanaoka
authors.forename: Shusuke
authors.initials: S
authors.lastname: Sone
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ino
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Takayama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanaya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ogata
mesh_terms: D000368:Aged; D018287:Carcinoma, Large Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed / Q000379:methods*