To 'B' regulated: B cells as members of the regulatory workforce.
Until recently, immune regulation was thought to be predominantly mediated by specialized subsets of T lymphocytes. However, although B lymphocytes have previously been shown to have regulatory properties in autoimmunity, a recent report by Knoechel et al. establishes a role for B lymphocytes in the control of pathogenic autoreactive T cell responses arising when the number of lymphocytes is abnormally low (lymphopenia).
Serra
Pau
P
Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Santamaria
Pere
P
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D008231:Lymphopenia / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000949:Histocompatibility Antigens Class II