Comparative analysis of the work of morphofunctional zones in normal epithelium, fibroadenoma, and cancer of the breast.
Twenty-four rosettes (proliferative epidermal units) in epithelial tissue are united into morphofunctional zones, where cambial cells proliferate with the formation of maternal and daughter cells and these latter ones differentiate under the influence of electrical field generated by 12 maternal cells. The number of cambial cells in morphofunctional zone of a malignant tumor is reduced at least 2-fold. Hence, the number of maternal cells is reduced to 6, which is insufficient for electric field generation and stimulation of daughter cells differentiation. The percentage of cambial cells in a benign tumor decreases 1.5 times. Daughter cells are differentiated in an electric field whose strength is below optimal, but above the threshold value at which cells do not differentiate; hence, differentiation is incomplete.
Yavisheva
T M
TM
N. N. Blokhin National Oncological Research Center, Moscow.
Shcherbakov
S D
SD
Golubeva
I S
IS
Savluchinskaya
L A
LA
D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D002478:Cells, Cultured; D046508:Culture Techniques; D004574:Electromagnetic Fields; D004848:Epithelium / Q000378:metabolism*; D005260:Female; D018226:Fibroadenoma / Q000378:metabolism*; D006801:Humans; D018715:Microscopy, Video; D008875:Middle Aged