title: Enhancement of diffusion-controlled reaction rates by surface-induced orientational restriction.
abstract: We explore the means by which immobilization of a substrate on a surface can increase the rate of a diffusion-controlled enzymatic reaction. A quasichemical approach is developed and compared with Brownian dynamics simulations. We use these methods to show that restricting only the orientation of the enzyme by long-range interactions with the surface is sufficient for enhancing catalysis.
authors.affiliation: Department of Chemistry, James Franck Institute, Institute for Biophysical Dynamics, and Committee on Immunology, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Ambarish
authors.initials: A
authors.lastname: Nag
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Dinner
mesh_terms: D001703:Biophysics / Q000379:methods*; D002384:Catalysis; D003198:Computer Simulation; D004058:Diffusion; D004583:Electrons; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D015233:Models, Statistical; D008962:Models, Theoretical; D011485:Protein Binding; D055672:Static Electricity; D013379:Substrate Specificity