Discovery of a potent phenolic N1-benzylidene-pyridinecarboxamidrazone selective against Gram-positive bacteria.
As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria.
Rathbone
Daniel L
DL
School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK. D.L.Rathbone@aston.ac.uk
Parker
Katy J
KJ
Coleman
Michael D
MD
Lambert
Peter A
PA
Billington
David C
DC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011725:Pyridines