title: Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses.
abstract: BACKGROUND
  Lidocaine constant rate infusions (CRIs) are common as an intraoperative adjunct to general anaesthesia, but their influence on quality of recovery has not been thoroughly determined.
  
  
  OBJECTIVE
  To determine the effects of an intraoperative i.v. CRI of lidocaine on the quality of recovery from isoflurane or sevoflurane anaesthesia in horses undergoing various surgical procedures, using a modified recovery score system.
  
  
  OBJECTIVE
  The administration of intraoperative lidocaine CRI decreases the quality of recovery in horses.
  
  
  METHODS
  Lidocaine (2 mg/kg bwt bolus followed by 50 microg/kg bwt/min) or saline was administered for the duration of surgery or until 30 mins before the end of surgery under isoflurane (n = 27) and sevoflurane (n = 27).
  
  
  RESULTS
  Horses receiving lidocaine until the end of surgery had a significantly higher degree of ataxia and a tendency towards significance for a lower quality of recovery. There was no correlation between lidocaine plasma concentrations at recovery and the quality of recovery.
  
  
  CONCLUSIONS
  Intraoperative CRI of lidocaine affects the degree of ataxia and may decrease the quality of recovery.
  
  
  CONCLUSIONS
  Discontinuing lidocaine CRI 30 mins before the end of surgery is recommended to reduce ataxia during the recovery period.
authors.affiliation: Department of Large Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA.
authors.forename: A
authors.initials: A
authors.lastname: Valverde
authors.forename: C
authors.initials: C
authors.lastname: Gunkelt
authors.forename: T J
authors.initials: TJ
authors.lastname: Doherty
authors.forename: S
authors.initials: S
authors.lastname: Giguère
authors.forename: A S
authors.initials: AS
authors.lastname: Pollak
mesh_terms: D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000502:physiology*; D007262:Infusions, Intravenous / Q000662:veterinary; D007430:Intraoperative Care / Q000662:veterinary; D007530:Isoflurane / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology*; D008738:Methyl Ethers / Q000494:pharmacology; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D008738:Methyl Ethers; D000077149:Sevoflurane; D008012:Lidocaine; D007530:Isoflurane