Facile regiocontrolled synthesis of trialkyl-substituted pyrazines.
[reaction: see text] Alpha-nitro ketones can be transformed selectively into trialkyl-substituted pyrazines via reaction with alpha-amino ketones using octyl viologen as an electron-transfer reagent. The new synthetic method, and the optimal reaction conditions that allow for the regiochemical control, are described.
Elmaaty
Tarek Abou
TA
Department of Chemistry, Idaho State University, Campus Box 8023, Pocatello, Idaho 83209, USA.
Castle
Lyle W
LW