[Research advances on genetics of nevoid basal cell carcinoma syndrome].
Nevoid basal cell carcinoma syndrome is an autosomal dominant genetic disease characterized by developmental abnormalities and tumorigenesis. Currently the mutation of PTCH gene is considered to be the molecular defect of this syndrome. This paper reviews the present status and progress on genetics about this syndrome.
Lv
Yan
Y
Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, Shanghai Jiaotong University, China.
Chen
Wan-tao
WT
He
Rong-gen
RG
D001478:Basal Cell Nevus Syndrome; D006801:Humans; D009154:Mutation; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011956:Receptors, Cell Surface / Q000235:genetics*
C000606236:PTCH1 protein, human; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011956:Receptors, Cell Surface