Ziprasidone overdose: cardiac safety.
Ziprasidone is a neuroleptic drug recently sold in Spain. According to its profile of receptors it is considered an atypical or second generation antipsychotic agent. Its use has been associated to increase of the QT interval, which might trigger potentially lethal ventricular arrhythmia. We present a case of overdose with moderate doses of the drug, in which there were no important changes in the QT interval. A review of the cases of overdose published up to now was also done.
Insa Gómez
F J
FJ
Complejo Hospitalario Universitario, Badajoz, Spain. fjinsa@cavabianca.org
Gutiérrez Casares
J R
JR
D000328:Adult; D062787:Drug Overdose; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000188:drug therapy / Q000523:psychology; D010879:Piperazines / Q000009:adverse effects*; D012702:Serotonin Antagonists / Q000009:adverse effects*; D013844:Thiazoles / Q000009:adverse effects*
D010879:Piperazines; D012702:Serotonin Antagonists; D013844:Thiazoles; C092292:ziprasidone