title: Receptor-mediated clearance of Cryptococcus neoformans capsular polysaccharide in vivo.
abstract: Cryptococcus neoformans capsular glucuronoxylomannan (GXM) is shed during cryptococcosis and taken up by macrophages. The roles of the putative GXM receptors CD14, CD18, Toll-like receptor 2 (TLR2), and TLR4 in GXM clearance from serum and deposition in the liver and spleen in receptor-deficient mice were studied. While alterations in the kinetics of GXM redistribution were seen in the mutant mice, none of the receptors was absolutely required for serum clearance or hepatosplenic accumulation.
authors.affiliation: Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Yauch
authors.forename: Michael K
authors.initials: MK
authors.lastname: Mansour
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Levitz
mesh_terms: D000818:Animals; D016667:Bacterial Capsules / Q000737:chemistry / Q000378:metabolism*; D003453:Cryptococcosis / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D003455:Cryptococcus neoformans / Q000472:pathogenicity*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D011134:Polysaccharides / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology*; D013154:Spleen / Q000378:metabolism
chemical_list: D011134:Polysaccharides; D011971:Receptors, Immunologic; C027478:glucuronoxylomannan