Self-activating nuclease activity of copper (II) complexes of hydroxyl-rich ligands.
Copper (II) complexes of Schiff bases derived from [1+1] condensation of salicylaldehyde, 2,3-dihydroxybenzaldehyde and 2,3,4-trihydroxybenzaldehyde with anthranilic acid (L1-L3) have been synthesized and characterized by elemental analyses, IR, UV-Vis spectra, room temperature magnetic susceptibility, electron paramagnetic resonance spectroscopy and cyclic voltammetry. The X-ray structure of [CuL1]n has been solved and refined to R = 0.0314. The crystals are monoclinic with space group P2(1) with cell constants a = 9.6820(13), b = 7.1446(11), c = 9.9315(13) A, beta = 98.385(8) degrees, Z = 2. The copper (II) ions are in a distorted tetrahedral environment sequentially bridged by carboxylate groups in the syn-anti conformation giving rise to a helix-like chain. The copper complexes with the inherent redox active hydroquinone functionality cleave plasmid pBR322 DNA without exogenous agents by a self-activating mechanism.
Tonde
Sunil S
SS
Department of Chemistry, University of Pune, Ganeshkhind Road, Pune 411 007, India.
Kumbhar
Avinash S
AS
Padhye
Subhash B
SB
Butcher
Ray J
RJ
D000975:Antioxidants / Q000737:chemistry; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D006873:Hydroquinones / Q000737:chemistry / Q000378:metabolism; D017665:Hydroxyl Radical / Q000737:chemistry*; D008024:Ligands; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
D000975:Antioxidants; D006873:Hydroquinones; D008024:Ligands; D017665:Hydroxyl Radical; D003300:Copper; D004247:DNA; C031927:hydroquinone