Nanoparticles of biodegradable polymers for new-concept chemotherapy.
The current regimen of chemotherapy is far from satisfactory--its efficiency is limited and patients suffer from serious side effects. Various drug delivery devices have been under intensive investigation in the past few decades in attempts to develop controlled and targeted methods of chemotherapy administration. This article reviews the latest developments in nanoparticles of biodegradable polymers for chemotherapy of cancer and other diseases such as cardiovascular restenosis. The preliminary results obtained in the author's laboratory are used to demonstrate the concept. This review is written with the belief that engineering, in particular, chemical engineering principles, can be applied and further developed to solve the problems in the current practice of chemotherapy and promote a new concept of chemotherapy - chemotherapy at home.
Feng
Si-Shen
SS
Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260. chefss@nus.edu.sg
D020341:Absorbable Implants; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D004343:Drug Implants / Q000627:therapeutic use*; D004358:Drug Therapy / Q000379:methods / Q000639:trends; D005544:Forecasting; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D043942:Nanotubes; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004343:Drug Implants; D011108:Polymers