title: Vaccine safety controversies and the future of vaccination programs.
abstract: In the years following the hepatitis B vaccination/multiple sclerosis controversy, a number of new issues regarding vaccine safety have been raised, in some cases leading to more debate and confusion. Against this background, an international group of experts was convened to review the current points of view concerning the use of thimerosal as a preservative and its potential risks; the suggested link between thimerosal-containing vaccines and acute lymphoblastic leukemia; the alleged association between aluminum-containing vaccines/macrophagic myofasciitis and general systemic complaints; a possible link between vaccination and autoimmune pathology; and a hypothetical link between measles-mumps-rubella vaccination and autism. At present, there are no data to conclude that childhood vaccines, and in particular hepatitis B vaccine, pose a serious health risk or justify a change in current immunization practice. However, vaccine "scares" continue to have an international impact on immunization coverage. Creating a positive environment for immunization can be achieved by repositioning the value of vaccines and vaccination, supported by evidence-based information. The role of international organizations, the media, and the industry in the implementation of communication strategies was discussed and the impact of litigation issues on vaccination was evaluated. The Viral Hepatitis Prevention Board confirms its commitment to current recommendations for universal and risk group hepatitis B vaccination and further encourages the conduct of vaccine safety studies and the dissemination of their results.
authors.affiliation: Viral Hepatitis Prevention Board, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, Department of Epidemiology and Social Medicine, University of Antwerpen, Antwerp, Belgium. guido.francois@ua.ac.be
authors.forename: Guido
authors.initials: G
authors.lastname: François
authors.forename: Philippe
authors.initials: P
authors.lastname: Duclos
authors.forename: Harold
authors.initials: H
authors.lastname: Margolis
authors.forename: Daniel
authors.initials: D
authors.lastname: Lavanchy
authors.forename: Claire-Anne
authors.initials: CA
authors.lastname: Siegrist
authors.forename: André
authors.initials: A
authors.lastname: Meheus
authors.forename: Paul-Henri
authors.initials: PH
authors.lastname: Lambert
authors.forename: Nedret
authors.initials: N
authors.lastname: Emiroğlu
authors.forename: Selim
authors.initials: S
authors.lastname: Badur
authors.forename: Pierre
authors.initials: P
authors.lastname: Van Damme
mesh_terms: D002648:Child; D014943:Global Health; D007722:Health Knowledge, Attitudes, Practice; D017325:Hepatitis B Vaccines / Q000009:adverse effects; D006801:Humans; D007114:Immunization / Q000592:standards; D007115:Immunization Schedule; D012306:Risk; D012449:Safety; D016312:Treatment Refusal; D014611:Vaccination / Q000009:adverse effects* / Q000592:standards*
chemical_list: D017325:Hepatitis B Vaccines