Cerebrospinal fluid catecholamine levels in Japanese encephalitis patients with movement disorders.
Norepinephrine and dopamine have important role in movement disorders but their role in movement disorders associated with Japanese encephalitis (JE) has not been evaluated. Therefore, in the present study, cerebrospinal fluid (CSF) catecholamine levels and its metabolites in JE patients with movement disorders were compared with those without JE. CSF was collected by lumbar puncture and analyzed by HPLC-ED. Norepinephrine, dopamine and homovanillic acid concentrations were significantly (P<0.005) lower in JE patients compared to control groups. Low levels of catecholamines in JE associated movement disorders compared to idiopathic Parkinson's disease and other extrapyramidal symptoms may be due to severe structural damage to thalamus, basal ganglia and brainstem in JE patients as revealed by MRI findings.
Misra
U K
UK
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical sciences, RaeBarali Road, 226014, Lucknow, India.
Kalita
J
J
Pandey
S
S
Khanna
V K
VK
Babu
G Nagesh
GN
D000293:Adolescent; D000328:Adult; D002395:Catecholamines / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D004672:Encephalitis, Japanese / Q000134:cerebrospinal fluid* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009069:Movement Disorders / Q000134:cerebrospinal fluid* / Q000821:virology; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000473:pathology / Q000503:physiopathology
D002395:Catecholamines