Determination of the minmum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in rats.
In order to determine the minimum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in Sprague-Dawley rats, each rat was infected with 30 metacercariae and treated with one of three drugs. The rats were killed and examined 25 days after praziquantel treatment or 11 days after albendazole or mebendazole treatment. The minimum effective dosages were a single dose of praziquantel 375 mg/kg, albendazole 150 mg/kg, and mebendazole 150 mg/kg. Trials are required to determine whether these dosages are useful in the treatment of human clonorchiasis.
Fan
Ping-Chin
PC
Institute of Tropical Medicine and Department of Parasitology, National Yangming University, Taipei, Taiwan. pcfan@ym.edu.tw
Wu
Chin-Cheng
CC
Huang
Ping
P
Yen
Chih-Wei
CW
D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D003003:Clonorchiasis / Q000188:drug therapy* / Q000469:parasitology; D003004:Clonorchis sinensis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
D000871:Anthelmintics; D011223:Praziquantel; D008463:Mebendazole; D015766:Albendazole