Unshackling the links between reovirus oncolysis, Ras signaling, translational control and cancer.
Reovirus has an inherent preference for replicating in cells with dysregulated growth factor signaling cascades that comprise Ras activation. Precisely how reovirus exploits the host cell Ras pathway is unclear, but there is evidence suggesting that activated Ras signaling is important for efficient viral protein synthesis. Defining the molecular mechanism of reovirus oncolysis will shed light on reovirus replication and important aspects of cellular transformation, Ras signaling cascades and regulation of protein translation.
Shmulevitz
Maya
M
Department of Microbiology and Immunology, Dalhousie University, 7P Sir Charles Tupper Medical Building, Halifax, NS, Canada.
Marcato
Paola
P
Lee
Patrick W K
PW
D002471:Cell Transformation, Neoplastic; D009369:Neoplasms / Q000628:therapy / Q000821:virology; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000502:physiology; D014176:Protein Biosynthesis; D012087:Reoviridae / Q000235:genetics / Q000502:physiology*; D012088:Reoviridae Infections; D015398:Signal Transduction; D014779:Virus Replication; D019892:eIF-2 Kinase / Q000378:metabolism; D018631:ras Proteins / Q000502:physiology*
D019892:eIF-2 Kinase; D018631:ras Proteins