Glucose encapsulation in catanionic vesicles and kinetic study of the entrapment/release processes in the sodium dodecyl benzene sulfonate/cetyltrimethylammonium tosylate/water system.
The sodium dodecyl benzene sulfonate (SDBS)/cetyltrimethyl-ammonium tosylate (CTAT)/water ternary system has previously been shown to give rise to the formation of vesicles for well-defined compositions requiring an excess of one of the surfactants over the other. Two types of vesicular systems can thus be obtained (named V(+) and V(-), depending on the nature of the excess surfactant, i.e., CTAT or SDBS, respectively). In addition, the pure ion-pair amphiphile (IPA) can be obtained after removing the counterions. These different systems (V(+), V(-), and IPA) were investigated in regards to their ability to susbtantially retain a hydrophilic probe such as glucose. The influence of the initial glucose and surfactant concentrations was studied, and dialysis experiments were conducted with a view to determine the kinetics of glucose entrapment and release by the vesicles and, thus, to assess the possibility of a long-term encapsulation. The results indicate that all the vesicular systems studied here are characterized by quite a high permeability of the amphiphilic bilayer. However, SDBS-rich (V(-)) and IPA vesicles proved to be less permeable than CTAT-rich (V(+)) vesicles.
Fischer
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Laboratoire de Chimie Physique Organique et Colloïdale, Unité Mixte de Recherche CNRS-UHP (UMR 7565), Université Henri Poincaré-Nancy 1, B.P. 239, Vandoeuvre-les-Nancy Cedex, 54506, France.
Hebrant
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Tondre
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D001557:Benzenesulfonates / Q000737:chemistry*; D002593:Cetrimonium Compounds / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D013997:Time Factors; D014867:Water / Q000737:chemistry
D001557:Benzenesulfonates; D002593:Cetrimonium Compounds; D014867:Water; C020810:trimethylcetylammonium p-toluenesulfonate; C001114:dodecylbenzenesulfonic acid; D005947:Glucose