[A study on cytocompatibility of poly (lactic acid) membrane modified by polymer microspheres with different surface charges].
Poly(lactic acid) microspheres with different surface charges have been prepared by using cationic, anionic or nonionic surfactants as the microspheres' surface stabilizers. Embedded with these microspheres, the modified PLA membranes with different surface charges have been obtained. The test of stability by CLSM and the morphological test by SEM confirmed that we obtained the microspheres modified PLA membranes with different surface charges successfully. The chondrocyte compatibility test of these modified PLA membranes showed that the attachment, proliferation and activity of chondrocytes on the positive surface of the modified PLA were better than those of other modified PLA membranes. The positive charge on the surface of PLA membrane could improve the cell-compatibility of PLA well.
Chen
Da
D
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Ji
Jian
J
Shen
Jiacong
J
D000818:Animals; D000831:Animals, Newborn; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002412:Cations; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D008567:Membranes, Artificial; D008863:Microspheres; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011817:Rabbits; D013501:Surface-Active Agents / Q000737:chemistry
D001672:Biocompatible Materials; D002412:Cations; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D013501:Surface-Active Agents; D019344:Lactic Acid; C033616:poly(lactide)