[Effects of high-dose cortisone therapy on cognition].
Treatment with high-dose corticosteroids over 3-5 days reduces the duration and severity of relapses in patients with multiple sclerosis. Since the benefit of this treatment appears to be dose-dependent, application of ultrahigh steroid doses becomes important. On the other hand, data from basic research and clinical studies indicate potential side effects on mnestic functions. Three recently published studies show that treatment with pulsed corticosteroids induces reversible impaired memory. The effects were independent of the dose administered.
Uttner
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I
Neurologische Klinik der Universität Ulm.
Tumani
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H
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000139:chemically induced* / Q000517:prevention & control; D003348:Cortisone / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
D000893:Anti-Inflammatory Agents; D003348:Cortisone