title: [Low-dose therapy with carbamazepine for convulsions associated with mild gastroenteritis].
abstract: We investigated the effect of carbamazepine on convulsions associated with mild gastroenteritis. Sixteen infants and young children (aged 9 months to 3 years) who experienced repetitive convulsions associated with mild gastroenteritis were admitted to our hospital. We treated the sixteen affected patients with 5 mg/kg of carbamazepine once per day until the diarrhea had stopped. Thirteen of the sixteen patients were subjected to intravenous and/or suppository administration of diazepam (0.3-0.5 mg/kg/time), and one patient suppository administration of 0.5 mg/kg diazepam and 5.7 mg/kg phenobarbital before the administration of carbamazepine. In all patients who were given diazepam and/or phenobarbital, the convulsions recurred after the administration of these medicines. The convulsions occurred 2 to 8 times (mean, 4.1 times) before the administration of carbamazepine. Fifteen of the sixteen patients had no seizures after the administration of carbamazepine. One patient had one convulsion 15 min after the administration of carbamazepine. All patients were treated with 5 mg/kg of carbamazepine once per day until the diarrhea had stopped, i.e. for 2 to 9 days (mean, 6.4 days). Low dose therapy with carbamazepine once per day is thus effective for convulsions associated with mild gastroenteritis.
authors.affiliation: Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi. ichiyama@yamaguchi-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichiyama
authors.forename: Hironori
authors.initials: H
authors.lastname: Matsufuji
authors.forename: Naoko
authors.initials: N
authors.lastname: Suenaga
authors.forename: Miki
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Furukawa
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage*; D002220:Carbamazepine / Q000008:administration & dosage*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004569:Electroencephalography; D005260:Female; D005759:Gastroenteritis / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine