Acute bacterial meningitis in a patient receiving ibuprofen.
We report an atypical presentation of meningitis due to Neisseria meningitidis in a patient who received large doses of ibuprofen. Anti-inflammatory therapy such as NSAIDs could reduce CSF inflammation and modify the clinical outcome in patients with bacterial meningitis. However, the use of NSAIDs is not recommended in bacterial meningitis due to a lack of studies.
Tamburini
Jérôme
J
Department of Infectious Diseases, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75651 Paris, Cedex 13-France.
Grimaldi
David
D
Bricaire
François
F
Bossi
Philippe
P
D000293:Adolescent; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000075202:Contraindications; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008218:Lymphocytosis / Q000209:etiology; D008297:Male; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000188:drug therapy / Q000382:microbiology; D009345:Neisseria meningitidis / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000658:Amoxicillin; D007052:Ibuprofen