title: Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors.
abstract: Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI develop dementia. We followed up 165 elderly outpatients with MCI for a mean of 3 years. The aims were (1) to investigate the risk of conversion to dementia for different MCI subtypes diagnosed according to standardized criteria (amnestic; impairment of memory plus other cognitive domains; nonamnestic); (2) to assess whether the risk of conversion was affected by several established and emerging vascular risk factors. Forty-eight subjects (29%) converted to dementia, and the risk of conversion was doubled for amnestic MCI with respect to the other subtypes. Independently of MCI subtype, risk of conversion was associated with atrial fibrillation and low serum folate levels. Our results show that current diagnostic criteria for MCI define heterogeneous populations, but some potentially treatable vascular risk factors may be of help in predicting conversion to dementia.
authors.affiliation: Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy. ravaglia@med.unibo.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ravaglia
authors.forename: Paola
authors.initials: P
authors.lastname: Forti
authors.forename: Fabiola
authors.initials: F
authors.lastname: Maioli
authors.forename: Mabel
authors.initials: M
authors.lastname: Martelli
authors.forename: Lucia
authors.initials: L
authors.lastname: Servadei
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Brunetti
authors.forename: Gaia
authors.initials: G
authors.lastname: Pantieri
authors.forename: Erminia
authors.initials: E
authors.lastname: Mariani
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D000647:Amnesia / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D001281:Atrial Fibrillation / Q000150:complications / Q000453:epidemiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000523:psychology; D018450:Disease Progression; D005492:Folic Acid / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D011379:Prognosis; D012307:Risk Factors
chemical_list: D005492:Folic Acid