title: [Heart transplantation].
abstract: While nearly 4,000 patients undergo heart transplantation (HTx) every year in the world, only 27 HTx were performed since February, 1999, because of very strict Organ Transplantation Law in Japan. All were treated with triple immunosuppressive regimen. Although two patients died of infection 4 months and 4 years after HTx, respectively, 23 were discharged and 16 returned to work or go to school. New immunosuppressive drugs, such as sirolimus and everolimus, treatment of presensitized patients before transplantation using cyclophosphamide and intravenous globulin infusion, compact implantable left ventricular assist supports and the future of pediatric HTx in Japan are discussed.
authors.affiliation: Department of Surgery, Osaka University Graduate School of Medicine.
authors.forename: Norihide
authors.initials: N
authors.lastname: Fukushima
authors.forename: Hikaru
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D002648:Child; D016027:Heart Transplantation / Q000706:statistics & numerical data; D006801:Humans; D007165:Immunosuppression Therapy; D007564:Japan