title: Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people: Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study.
abstract: Several cohort studies have examined the association of carotid intima-media thickness (IMT) with the risk of stroke or myocardial infarction in apparently healthy persons. We investigated the predictive value of IMT of cardiovascular mortality in elderly community-dwelling people, beyond the prediction provided by age and MMSE, assessed by means of a multivariate Cox model. Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 298 people older than 75 years (120 men and 178 women, average age: 79.6 years). The LILAC study started on July 25, 2000. Consultations were repeated every year. The follow-up ended on November 30, 2004. During the mean follow-up span of 1152 days, 30 subjects (21 men and nine women) died. Nine deaths were attributable to cardiovascular causes (myocardial infarction: two men and three women; stroke: two men and two women). The age- and MMSE-adjusted relative risk (RR) and 95% confidence interval (95% CI) of developing all-cause mortality was assessed. A 0.3 mm increase in left IMT was associated with a RR of predicted 1.647 (1.075-2.524), and a similar increase in right IMT with a RR of 3.327 (1.429-7.746). For cardiovascular mortality, the corresponding RR values were 2.351 (1.029-5.372) and 2.890 (1.059-7.891), respectively. Carotid IMT assessed by ultrasonography is positively associated with an increased risk of all-cause and cardiovascular death in elderly community-dwelling people.
authors.affiliation: Department of Medicine, Medical Center East, Tokyo Women's Medical University, Nishiogu 2-1-10, Arakawa, Tokyo 116-8567, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
authors.forename: N
authors.initials: N
authors.lastname: Hotta
authors.forename: G
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Kubo
authors.forename: O
authors.initials: O
authors.lastname: Matsuoka
authors.forename: T
authors.initials: T
authors.lastname: Yamanaka
authors.forename: M
authors.initials: M
authors.lastname: Shinagawa
authors.forename: S
authors.initials: S
authors.lastname: Nunoda
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: E
authors.initials: E
authors.lastname: Takasugi
authors.forename: M
authors.initials: M
authors.lastname: Nishinaga
authors.forename: M
authors.initials: M
authors.lastname: Ishine
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: K
authors.initials: K
authors.lastname: Okumiya
authors.forename: K
authors.initials: K
authors.lastname: Matsubayashi
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: K
authors.initials: K
authors.lastname: Ichihara
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000367:Age Factors; D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000401:mortality*; D017536:Carotid Artery, Common / Q000473:pathology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008136:Longevity / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales