title: Primary synovial sarcoma of the mitral valve.
abstract: Primary cardiac synovial sarcoma is a rare malignancy, comprising approximately 5% of cardiac sarcomas and less than 0.1% of all primary cardiac tumors. Herein, we describe a synovial sarcoma arising on the anterior mitral leaflet in a 66-year-old man. The histopathologic diagnosis was supported by the immunohistochemical profile and the presence of the SYT-SSX1 fusion transcript identified by molecular genetic studies.
authors.affiliation: Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Dylan V
authors.initials: DV
authors.lastname: Miller
authors.forename: Arjun
authors.initials: A
authors.lastname: Deb
authors.forename: William D
authors.initials: WD
authors.lastname: Edwards
authors.forename: Kenton J
authors.initials: KJ
authors.lastname: Zehr
authors.forename: Andre M
authors.initials: AM
authors.lastname: Oliveira
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D004452:Echocardiography; D006338:Heart Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008943:Mitral Valve / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein