Ruthenium-catalyzed cycloaddition of alkynes and organic azides.
Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.
Zhang
Li
L
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
Chen
Xinguo
X
Xue
Peng
P
Sun
Herman H Y
HH
Williams
Ian D
ID
Sharpless
K Barry
KB
Fokin
Valery V
VV
Jia
Guochen
G
D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; C044736:phenylacetylene; D012428:Ruthenium; D000114:Acetylene