title: Solid pseudopapillary tumor of the pancreas with metastases to the lung and liver.
abstract: Presented herein is the case of a 41-year-old woman who was admitted to Teikyo University Hospital with abdominal and back pain. Clinical examination revealed a large mass of the pancreas and multiple nodules in the liver. After surgical resection of the pancreatic and liver tumors, liver nodules recurred repeatedly, and a solitary mass lesion occurred in the right lung. Grossly, the pancreatic tumor was large and partially cystic. Histologically, small and uniform tumor cells proliferated, having solid and pseudopapillary patterns. These pathological findings enabled a pathological diagnosis of solid pseudopapillary tumor (SPT) of the pancreas to be made. The pathological appearance of the liver and lung tumors was similar to that of the pancreatic tumor. This is the first report of a case of pancreatic SPT that showed lung metastasis. It should be kept in mind that pancreatic SPT may take such an aggressive clinical course, although they are usually benign in nature.
authors.affiliation: Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan. ytakaha-tky@umin.ac.jp
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Fukusato
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Aita
authors.forename: Suzuko
authors.initials: S
authors.lastname: Toida
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Fukushima
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Imamura
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Tanaka
authors.forename: Hodaka
authors.initials: H
authors.lastname: Amano
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Takada
authors.forename: Shigeo
authors.initials: S
authors.lastname: Mori
mesh_terms: D000328:Adult; D018283:Cystadenocarcinoma, Papillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: C495270:CTNNB1 protein, human; D051176:beta Catenin