title: Diversity oriented synthesis of tricyclic compounds from glycals using the Ferrier and the Pauson-Khand reactions.
abstract: Diversity oriented synthesis of tricyclic compounds was achieved using a combination of the Ferrier reaction and the Pauson-Khand reaction. Ferrier reaction was effected using NbCl5, and the Pauson-Khand reaction was carried out using Co2(CO)8, acetonitrile-dimethoxyethane. Michael additions using various alkyl, aryl, and heterocyclic thiols were also performed successfully. The Ferrier, Pauson-Khand, and Michael addition reactions were found to be highly diastereoselective.
authors.affiliation: Combi Chem-Bio Resource Center, Division of Organic Chemistry: Synthesis, National Chemical Laboratory, Pune-411 008, India. s.hotha@ncl.res.in
authors.forename: Srinivas
authors.initials: S
authors.lastname: Hotha
authors.forename: Ashish
authors.initials: A
authors.lastname: Tripathi