Microcytosis in agnogenic myeloid metaplasia: prevalence and clinical correlates.
Microcytosis is a characteristic laboratory feature for both iron deficiency anemia and thalassemia. It is also infrequently seen in "anemia of chronic disease" that accompanies a spectrum of chronic conditions including rheumatoid arthritis, polymyalgia rheumatica, diabetes mellitus, connective tissue disease, and protracted infection. In addition, there is a well established but pathogenetically obscure association of microcytosis with Hodgkin's lymphoma, Castleman's disease, and renal cell carcinoma. In the current study, we show that microcytosis is a frequent laboratory feature in agnogenic myeloid metaplasia and investigate its clinical relevance in the particular setting.
Tefferi
Ayalew
A
Division of Hematology, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA. tefferi.ayalew@mayo.edu
Dingli
David
D
Li
Chin-Yang
CY
Mesa
Ruben A
RA
D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000401:mortality / Q000473:pathology; D000748:Anemia, Macrocytic / Q000150:complications / Q000401:mortality* / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000401:mortality / Q000473:pathology; D005871:Castleman Disease / Q000150:complications / Q000401:mortality / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055728:Primary Myelofibrosis / Q000150:complications / Q000401:mortality* / Q000473:pathology; D013789:Thalassemia / Q000150:complications / Q000401:mortality / Q000473:pathology