title: Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia.
abstract: Lungs are the central organ affected and targeted by Mycobacterium tuberculosis and immune processes in the lung are of critical importance in the pathogenesis of tuberculosis. A major lung defense against invading pathogens is provided by surfactant protein A, a multi-chain protein encoded by the SFTPA1 and SFTPA2 genes. Here, we investigated polymorphisms in the SFTPA1 and SFTPA2 genes for association with tuberculosis in 181 Ethiopian families comprising 226 tuberculosis cases. Four polymorphisms, SFTPA1 307A, SFTPA1 776T, SFTPA2 355C, and SFTPA2 751C, were associated with tuberculosis (P=0.00008; P=0.019, P=0.029 and P=0.042, respectively). Additional subgroup analysis in male, female and more severely affected patients provided evidence for SFTPA1/2-covariate interaction. Finally, out of five intragenic haplotypes identified in the SFTPA1 gene and nine identified in the SFTPA2 gene, 1A(3) was most significantly associated with tuberculosis susceptibility (P=0.026). These findings suggest that SFTPA1 and SFTPA2 modify the risk of tuberculosis susceptibility and that this risk is influenced by additional covariates.
authors.affiliation: McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, McGill University, Montreal, Quebec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Malik
authors.forename: C M T
authors.initials: CM
authors.lastname: Greenwood
authors.forename: T
authors.initials: T
authors.lastname: Eguale
authors.forename: A
authors.initials: A
authors.lastname: Kifle
authors.forename: J
authors.initials: J
authors.lastname: Beyene
authors.forename: A
authors.initials: A
authors.lastname: Habte
authors.forename: A
authors.initials: A
authors.lastname: Tadesse
authors.forename: H
authors.initials: H
authors.lastname: Gebrexabher
authors.forename: S
authors.initials: S
authors.lastname: Britton
authors.forename: E
authors.initials: E
authors.lastname: Schurr
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D018450:Disease Progression; D005002:Ethiopia; D005190:Family; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D037662:Pulmonary Surfactant-Associated Protein A / Q000235:genetics*; D014376:Tuberculosis / Q000235:genetics*
chemical_list: D037662:Pulmonary Surfactant-Associated Protein A; C445842:SFTPA1 protein, human; C445843:SFTPA2 protein, human