title: [Synthesis of peptide fragment of melittin and the function of rheumatoid arthritis cure].
abstract: To retain the anti-rheumatoid arthritis activity of melittin and to reduce the hemolysis and hypersusceptibility caused by melittin, a deletion peptide of melittin was synthesized. Its ant-inflammation effect was observed . A hydrophile peptide fragment of melittin was synthesized by standard solid-phase method. The product was analyzed by HPLC and MS. The relevant hemolysis and hypersusceptibility were tested. The rabbits' model of immune arthritis were established and treated. The results showed that the hemolysis rate for peptide fragment was less than 5%, the hypersusceptibility rate was less than 8%. The hydrophile peptide fragment of melittin may retain anti-rheumatoid arthritis activity and reduce the melittin-induced hemolysis and hypersusceptibility.
authors.affiliation: Hepato-biliary Disease Institute, Tianjin The Third Center Hospital, Tianjin 300170, China.
authors.forename: Meili
authors.initials: M
authors.lastname: Yu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Li
authors.forename: Shuchang
authors.initials: S
authors.lastname: Fang
authors.forename: Junchen
authors.initials: J
authors.lastname: Xue
authors.forename: Jijing
authors.initials: J
authors.lastname: Song
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000628:therapy*; D008555:Melitten / Q000138:chemical synthesis* / Q000627:therapeutic use; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000627:therapeutic use; D011817:Rabbits
chemical_list: D010446:Peptide Fragments; D008555:Melitten