title: Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.
abstract: As part of the optimization process of the lead compound I a focussed library of diversely substituted pyridazin-3(2H)-ones containing a 3-oxo-3-phenylprop-1-en-1-yl or 3-phenylprop-2-enoyl fragment at position 5 has been obtained and evaluated as antiplatelet agents. The structural modification at positions 2, 6 and 4 of the heterocyclic moiety allowed us to obtain preliminary information on the structure-activity relationship in this family.
authors.affiliation: Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, España, Spain.
authors.forename: Abel
authors.initials: A
authors.lastname: Crespo
authors.forename: Caroline
authors.initials: C
authors.lastname: Meyers
authors.forename: Alberto
authors.initials: A
authors.lastname: Coelho
authors.forename: Matilde
authors.initials: M
authors.lastname: Yáñez
authors.forename: Nuria
authors.initials: N
authors.lastname: Fraiz
authors.forename: Eddy
authors.initials: E
authors.lastname: Sotelo
authors.forename: Bert U W
authors.initials: BU
authors.lastname: Maes
authors.forename: Reyes
authors.initials: R
authors.lastname: Laguna
authors.forename: Ernesto
authors.initials: E
authors.lastname: Cano
authors.forename: Guy L F
authors.initials: GL
authors.lastname: Lemière
authors.forename: Enrique
authors.initials: E
authors.lastname: Raviña
mesh_terms: D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines