title: Oral pulsatile drug delivery systems.
abstract: In the field of modified release, there has been a growing interest in pulsatile delivery, which generally refers to the liberation of drugs following a programmable lag phase from the time of administration. In particular, the recent literature reports on a variety of pulsatile release systems intended for the oral route, which have been recognised as potentially beneficial to the chronotherapy of widespread diseases, such as bronchial asthma or angina pectoris, with mainly night or early morning symptoms. In addition, time-dependent colon delivery may also represent an appealing related application. The delayed liberation of orally administered drugs has been achieved through a range of formulation approaches, including single- or multiple-unit systems provided with release-controlling coatings, capsular devices and osmotic pumps. Based on these premises, the aim of this review is to outline the rational and prominent design strategies behind oral pulsatile delivery.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Maroni
authors.forename: Lucia
authors.initials: L
authors.lastname: Zema
authors.forename: Matteo
authors.initials: M
authors.lastname: Cerea
authors.forename: Maria Edvige
authors.initials: ME
authors.lastname: Sangalli
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D002463:Cell Membrane Permeability; D016503:Drug Delivery Systems; D006801:Humans; D009995:Osmosis
chemical_list: D002214:Capsules