Toxicokinetics and effects of PCBs in Arctic fish: a review of studies on Arctic charr.
In a series of environmentally realistic laboratory experiments, toxicokinetics and effects of polychlorinated biphenyls (PCBs) were studied in the Arctic charr (Salvelinus alpinus). Winter fasting and emaciation, which are common among Arctic charr living in high latitudes, resulted in a redistribution of the lipophilic PCBs from lipid-storing tissue such as the muscle, to vital organs that must be considered sensitive toward PCB (liver and brain). This redistribution was accompanied by a significant potentiation of the hepatic cytochrome P-450 (CYP) 1A biomarker response, from low activities in October (within those measured in uncontaminated charr) to a high, probably maximum, induction in May. Performance studies demonstrated a clear effect of environmentally realistic PCB levels on endocrine mechanisms, immune function, and seawater preadaptation (smoltification) in charr that had been feed deprived for several months after contamination with Aroclor 1254, whereas a high PCB dose exerted only minor, if any, effects in charr that had been fed after contamination. These results demonstrate that emaciation results in decreased dose-response relationships in fish, and indicate that arctic animals undergoing seasonal cycles of "fattening" and emaciation may be extra sensitive toward persistent, lipophilic organochlorines. Pilot studies on Arctic charr from Bjørnøya Island revealed marked CYP1A biomarker responses and an upregulation of genes involved in cellular homeostatic mechanisms in charr from Lake Ellasjøen (high PCB levels).
Jørgensen
Even H
EH
Norwegian Institute of Nature Research, The Polar Environmental Center, Tromsø. even.jorgensen@nfh.uit.no
Vijayan
Mathilakath M
MM
Killie
Jan-Eirik A
JE
Aluru
Neelakanteswar
N
Aas-Hansen
Øyvind
Ø
Maule
Alec
A
D000222:Adaptation, Physiological; D000818:Animals; D001822:Body Burden; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D007113:Immunity, Innate / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics* / Q000633:toxicity*; D013312:Stress, Physiological; D014337:Trout / Q000502:physiology*; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics* / Q000633:toxicity*
D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls; D019363:Cytochrome P-450 CYP1A1