Lanthanum inhibited the binding of LPS with monocyte and CD 14 expression upregulation.
To investigate the effects of lanthanum chloride on binding of LPS to monocyte and CD 14 expression upregulation induced by LPS, human monocytes were analyzed by flow cytometry (FCM). The results indicated that lanthanum chloride could decrease the binding rate of LPS with monocyte significantly. LPS upregulated the expression of CD 14 on monocyte in a dose dependant manner, however, lanthanum chloride could inhibit the increase of CD 14 expression on monocytes by halves.
Wang
Yang
Y
Institute of Urology, Jiangxi Medical College, Nanchang 330006, China. wangy63cn@sina.com
Guo
Fei
F
Hu
Feng
F
Wang
Gongxian
G
Li
Guohui
G
D005434:Flow Cytometry; D006801:Humans; D007811:Lanthanum / Q000494:pharmacology*; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis* / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects* / Q000276:immunology
D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; C028521:lanthanum chloride; D007811:Lanthanum