title: Allogeneic peripheral blood stem cell transplant (PBSCT) using anti-IL2 receptor antibody Daclizumab for the prevention of acute graft versus host disease in steroid refractory Diamond Blackfan anaemia: a case report.
abstract: The case report of a 2 year old boy with steroid refractory DBA, treated with allogeneic PBSCT from an HLA matched sibling is presented. Anti-IL2 receptor antibody Daclizumab was used as a prophylaxis for graft versus host disease (GvHD). Complete recovery without any evidence of GvHD ensued.
authors.affiliation: Bismillah Taqee Institute of Health Sciences and Blood Diseases Centre, Karachi, Pakistan.
authors.forename: Tahir Sultan
authors.initials: TS
authors.lastname: Shamsi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Irfan
authors.forename: Tasneem
authors.initials: T
authors.lastname: Farzana
authors.forename: Saqib Hussain
authors.initials: SH
authors.lastname: Ansari
authors.forename: Ghazala
authors.initials: G
authors.lastname: Ahmad
authors.forename: Nazmeen
authors.initials: N
authors.lastname: Shakoor
authors.forename: Mirza Irfan
authors.initials: MI
authors.lastname: Baig
mesh_terms: D000208:Acute Disease; D029503:Anemia, Diamond-Blackfan / Q000188:drug therapy / Q000601:surgery*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000077561:Daclizumab; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D015375:Receptors, Interleukin-2 / Q000037:antagonists & inhibitors* / Q000097:blood
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005938:Glucocorticoids; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D015375:Receptors, Interleukin-2; D000077561:Daclizumab