Signal-mediated export of proteins from the malaria parasite to the host erythrocyte.
Intracellular parasites from the genus Plasmodium reside and multiply in a variety of cells during their development. After invasion of human erythrocytes, asexual stages from the most virulent malaria parasite, P. falciparum, drastically change their host cell and export remodelling and virulence proteins. Recent data demonstrate that a specific NH(2)-terminal signal conserved across the genus Plasmodium plays a central role in this export process.
Marti
Matthias
M
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
Baum
Jake
J
Rug
Melanie
M
Tilley
Leann
L
Cowman
Alan F
AF
D000818:Animals; D001692:Biological Transport; D004910:Erythrocyte Membrane / Q000469:parasitology; D004912:Erythrocytes / Q000469:parasitology*; D006790:Host-Parasite Interactions; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology; D008954:Models, Biological; D010963:Plasmodium falciparum / Q000378:metabolism* / Q000502:physiology*; D021381:Protein Transport; D015398:Signal Transduction