title: [The influence of non-steroidal anti-inflammatory drugs on clinical outcome in patients with bleeding peptic ulcers].
abstract: OBJECTIVE
  We conducted this study to find the clinical characteristics of ulcer bleeding that occurred in patients who had been taking non-steroidal anti-inflammatory drugs (NSAIDs) and to evaluate the influences of NSAIDs on clinical outcomes.
  
  
  METHODS
  Between January 2000 and December 2002, a total of 310 patients with ulcer bleeding were analyzed. Study group composed of 49 patients who had taken NSAIDs regularly for at least 4 weeks before the admission. Other 261 patients who had not taken NSAIDs were classified as control group. Relevant informations were obtained from the medical records.
  
  
  RESULTS
  Of the NSAIDs group, aspirin was the most common medication. The mean age and the proportion of females in the NSAIDs group were significantly higher than those of the control group. Prevalence of co-morbid illness was significantly higher in the NSAIDs group than in the control group (85.7% vs 30.7%, p<.001). The severity of bleeding which was assessed by hemoglobin level at presentation, amount of transfusion, and duration of admission, was not different between two groups. There were no significant differences in frequency of re-bleeding, urgent surgery, and mortality.
  
  
  CONCLUSIONS
  Ulcer bleeding among patients taking NSAIDs occurred more frequently in older females with co- morbid illness. However, NSAIDs is not associated with higher morbidity and mortality.
authors.affiliation: Department of Internal Medicine, Hallym University School of Medicine, Seoul, Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Hak Yang
authors.initials: HY
authors.lastname: Kim
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Choi
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Young Deok
authors.initials: YD
authors.lastname: Bae
authors.forename: Gwang Ho
authors.initials: GH
authors.lastname: Baek
authors.forename: Myoung Kuk
authors.initials: MK
authors.lastname: Jang
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Jin Heon
authors.initials: JH
authors.lastname: Lee
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Yoo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced* / Q000150:complications
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal