title: Reactivity of Grubbs' catalysts with urea- and amide-substituted olefins. Metathesis and isomerization.
abstract: [Chemical reaction: see text] The reactions of a series of urea- and amide-substituted olefins with Grubbs' catalysts are presented. Depending on the substrate's nature, the formation of either cross-metathesis or isomerization products is observed. To favor the cross-metathesis products, the reactions have been carried out using a wide range of experimental conditions. Upon addition of monophenyl phosphoester to these reactions, the isomerization of the olefins is completely suppressed and the cross-metathesis products are obtained in up to 60% yield.
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom.
authors.forename: Pilar
authors.initials: P
authors.lastname: Formentín
authors.forename: Nélida
authors.initials: N
authors.lastname: Gimeno
authors.forename: Joachim H G
authors.initials: JH
authors.lastname: Steinke
authors.forename: Ramón
authors.initials: R
authors.lastname: Vilar