[CD34+ antigen expression relating to prognosis in acute myeloid leukemia].
To explore CD34(+) antigen expression in new diagnosed acute myeloid leukemia (AML) and analyze the prognosis for CD34(+) AML patients, the expression of antigen CD34 in 238 AML patients was detected by indirect immunofluorescence assay. The results showed that CD34 in 92 out of the 238 patients (38.7%) were positive, there was relationship between the CD34(+) expression and FAB subtypes (M(0), M(1)), and no CD34(+) expression was observed in M(3) subtypes. The complete remission rate of CD34(+) AML patients was 32%, which was lower than that of CD34(-) AML (61%). The lymphoid-associated antigen (CD7) was significantly increased in CD34(+) AML patients, compared with CD34(-) patients (P < 0.05). It is concluded that CD34(+) AML patients show poor prognosis and lower CR rate. The detection of CD34 expression is of some value in predicting prognosis in AML.
Li
Ling
L
Department of Hematology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
Wang
Rui
R
Zhong
Di
D
Wen
Bin-Zao
BZ
Abulaiti
Dilinazi
D
Lin
Zhi-Qiang
ZQ
Jia
Ming
M
Hao
Jian-Ping
JP
Chen
Rong
R
Guo
Xin-Hong
XH
Wang
Lei
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis*; D019011:Antigens, CD7 / Q000096:biosynthesis; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000378:metabolism / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D018952:Antigens, CD34; D019011:Antigens, CD7