title: A new chemical tool for exploring the physiological function of the PDE2 isozyme.
abstract: Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
authors.affiliation: Research Technology Center, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA. Robert.J.Chambers@pfizer.com
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Chambers
authors.forename: Kristin
authors.initials: K
authors.lastname: Abrams
authors.forename: Norman Y
authors.initials: NY
authors.lastname: Garceau
authors.forename: Ajith V
authors.initials: AV
authors.lastname: Kamath
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Manley
authors.forename: Susan C
authors.initials: SC
authors.lastname: Lilley
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Otte
authors.forename: Dennis O
authors.initials: DO
authors.lastname: Scott
authors.forename: Alissa L
authors.initials: AL
authors.lastname: Sheils
authors.forename: David A
authors.initials: DA
authors.lastname: Tess
authors.forename: A Samuel
authors.initials: AS
authors.lastname: Vellekoop
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kelvin T
authors.initials: KT
authors.lastname: Lam
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D054678:Cyclic Nucleotide Phosphodiesterases, Type 2; D004353:Drug Evaluation, Preclinical; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D007527:Isoenzymes / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D000078183:Oxindoles; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D010727:Phosphoric Diester Hydrolases / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D007527:Isoenzymes; D000078183:Oxindoles; D010726:Phosphodiesterase Inhibitors; C022960:2-oxindole; C010192:9-(2-hydroxy-3-nonyl)adenine; D010727:Phosphoric Diester Hydrolases; D054678:Cyclic Nucleotide Phosphodiesterases, Type 2; C517278:Pde2a protein, rat; D000225:Adenine