Effect of cetrorelix acetate on apoptosis and apoptosis regulatory factors in cultured uterine leiomyoma cells.
This report suggests the possibility that a gonadotropin-releasing hormone (GnRH) antagonist initiates apoptosis not only by causing a sex hormone deficit by inhibiting GnRH secretion in the pituitary gland, but also by acting directly on leiomyoma cells promoting apoptosis.
Kwon
Ja-Young
JY
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. jaykwon@yumc.yonsei.ac.kr
Park
Ki-Hyun
KH
Park
Young-Nyun
YN
Cho
Nam-Hoon
NH
D000328:Adult; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology*; D014407:Tumor Cells, Cultured; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*
D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix