title: Preparation and characterization of Boron carbide nanoparticles for use as a novel agent in T cell-guided boron neutron capture therapy.
abstract: Boron carbide nanoparticles are proposed as a system for T cell-guided boron neutron capture therapy. Nanoparticles were produced by ball milling in various atmospheres of commercially available boron carbide. The physical and chemical properties of the particles were investigated using transmission electron microscopy, photon correlation spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, vibrational spectroscopy, gel electrophoresis and chemical assays and reveal profound changes in surface chemistry and structural characteristics. In vitro thermal neutron irradiation of B16 melanoma cells incubated with sub-100 nm nanoparticles (381.5 microg/g (10)B) induces complete cell death. The nanoparticles alone induce no toxicity.
authors.affiliation: Nano-Science Center, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark.
authors.forename: M W
authors.initials: MW
authors.lastname: Mortensen
authors.forename: P G
authors.initials: PG
authors.lastname: Sørensen
authors.forename: O
authors.initials: O
authors.lastname: Björkdahl
authors.forename: M R
authors.initials: MR
authors.lastname: Jensen
authors.forename: H J G
authors.initials: HJ
authors.lastname: Gundersen
authors.forename: T
authors.initials: T
authors.lastname: Bjørnholm
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000528:radiation effects; D007553:Isotope Labeling; D008545:Melanoma / Q000473:pathology* / Q000532:radiotherapy*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D016499:Radioimmunotherapy / Q000379:methods*; D011868:Radioisotopes / Q000737:chemistry / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D013601:T-Lymphocytes / Q000637:transplantation*; D016896:Treatment Outcome
chemical_list: D001896:Boron Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals