title: Creatinine clearance and hemoglobin concentration before and after heart transplantation.
abstract: Clinical studies indicate that indices of glomerular filtration rate (GFR) as serum creatinine or creatinine clearance can predict the risk of death in congestive heart failure (CHF) and in heart transplantation. The study reports data on creatinine clearance before and after heart transplantation in 160 patients followed-up for 5 years at our Unit. Pre-transplant creatinine clearance averaged 83.5+/-32 mL/min x 1.73 m(2) and was not significantly associated with 5-year mortality. Creatinine clearance significantly decreased after heart transplantation with a linear trend up to 3 years for patients with complete follow-up. Data suggest that the relation between kidney function and mortality after heart transplantation is affected by several confounders with inclusion of cause of heart disease, co-morbidity, anemia, and post-transplant decrease in kidney function.
authors.affiliation: Departments of Nephrology and Heart Surgery, Second University of Naples, Naples, Italy. massimo.cirillo@unina2.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Cirillo
authors.forename: Luca S
authors.initials: LS
authors.lastname: De Santo
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Pollastro
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Romano
authors.forename: Ciro
authors.initials: C
authors.lastname: Mastroianni
authors.forename: Ciro
authors.initials: C
authors.lastname: Mastroiacono
authors.forename: Ciro
authors.initials: C
authors.lastname: Maiello
authors.forename: Cristiano
authors.initials: C
authors.lastname: Amarelli
authors.forename: Enzo
authors.initials: E
authors.lastname: Di Stazio
authors.forename: Alessandra
authors.initials: A
authors.lastname: Perna
authors.forename: Pietro
authors.initials: P
authors.lastname: Anastasio
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine*; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006333:Heart Failure / Q000175:diagnosis* / Q000401:mortality* / Q000652:urine; D016027:Heart Transplantation / Q000379:methods / Q000401:mortality*; D006403:Hematologic Tests; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D003404:Creatinine