title: Measurement of pulmonary edema in patients with acute respiratory distress syndrome.
abstract: OBJECTIVE
  We measured pulmonary edema by thermal indocyanine green-dye double-dilution technique and quantitative computed tomography (CT) in patients with acute respiratory distress syndrome and compared the two techniques.
  
  
  METHODS
  Prospective human study in a university hospital.
  
  
  METHODS
  Fourteen mechanically ventilated patients with acute respiratory distress syndrome (nine primary; nine with intubation <7 days).
  
  
  METHODS
  All patients underwent a spiral CT of the thorax. We measured pulmonary thermal volume (PTV) and its components, extravascular lung water and pulmonary blood volume, with an integrated fiberoptic monitoring system (COLD Z-021).
  
  
  RESULTS
  PTV was tightly correlated with lung weight (LW) measured by CT (PTV = 0.6875 * LW(CT) + 292.77; correlation coefficient = 0.91; p < .0001; bias -11 +/- 8 %). Neither etiology of acute respiratory distress syndrome (primary vs. secondary) nor days of intubation affected the accuracy of thermal dye dilution in comparison with CT. There was no correlation between the extravascular lung water (12.3 +/- 3.4 mL/kg) and CT distribution of lung tissue compartments. Extravascular lung water and pulmonary blood volume showed good reproducibility in 32 pairs of thermal dye dilution measurements.
  
  
  CONCLUSIONS
  Measurements of lung edema by thermal indocyanine green-dye double-dilution method show good correlation with those by quantitative computed tomography and good reproducibility in patients with acute respiratory distress syndrome.
authors.affiliation: Department of Surgical Sciences and Intensive Care, Milano-Bicocca University, San Gerardo Hospital, Monza, Milano, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Patroniti
authors.forename: Giacomo
authors.initials: G
authors.lastname: Bellani
authors.forename: Elena
authors.initials: E
authors.lastname: Maggioni
authors.forename: Annamaria
authors.initials: A
authors.lastname: Manfio
authors.forename: Barbara
authors.initials: B
authors.lastname: Marcora
authors.forename: Antonio
authors.initials: A
authors.lastname: Pesenti
mesh_terms: D000328:Adult; D000368:Aged; D004396:Coloring Agents; D015633:Extravascular Lung Water; D005260:Female; D006801:Humans; D007201:Indicator Dilution Techniques; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D011654:Pulmonary Edema / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D012128:Respiratory Distress Syndrome / Q000150:complications* / Q000209:etiology / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green