title: N-isopropyl-p- 123I iodoamphetamine single photon emission computed tomography study of Parkinson's disease with dementia.
abstract: BACKGROUND
  Intellectual deterioration occurs in 10-40% of patients with Parkinson's disease. However, there are many conflicting studies on its relation with brain perfusion and the nature of this dementing process remains controversial.
  
  
  OBJECTIVE
  To compare cortical perfusion by SPECT using (123)I-IMP between Parkinson's disease patients with dementia and those without dementia and to investigate the correlation between dementia in Parkinson's disease and brain perfusion in various areas.
  
  
  METHODS
  Fifty-two cases of Parkinson's disease and 10 control cases were studied. The Parkinson's disease with dementia group included 30 cases and the Parkinson's disease without dementia group included 22 cases.
  
  
  RESULTS
  By multiple logistic regression method, we demonstrated significant hypoperfusion in the occipital cortex in Parkinson's disease with dementia.
  
  
  CONCLUSIONS
  The cause of dementia in Parkinson's disease may vary. We demonstrated that occipital hypoperfusion was closely correlated to dementia in Parkinson's disease compared to frontal, parietal and temporal perfusion.
authors.affiliation: Department of Neurology, Sumitomo Hospital, Osaka.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsui
authors.forename: Fukashi
authors.initials: F
authors.lastname: Udaka
authors.forename: Takafumi
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Narihiro
authors.initials: N
authors.lastname: Hara
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamura
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kubori
authors.forename: Kazuto
authors.initials: K
authors.lastname: Nishinaka
authors.forename: Masakuni
authors.initials: M
authors.lastname: Kameyama
mesh_terms: D000368:Aged; D003704:Dementia / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D020367:Iofetamine; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine