title: [Corrosion behaviour, metal release and biocompatibility of implant materials coated by TiO2-sol gel chemistry].
abstract: Alloys based on titanium or cobalt have been used as implant materials for decades with good success. Because of their natural oxide layer these alloys reveal good corrosion behaviour. In contact with physiological solution metal release takes place, which can cause inflammation. Coatings can improve the corrosion behaviour. In this study Ti6Al4V and Co28Cr6Mo alloys, which are frequently used as implant materials, were tested. Polished discs of these alloys and polished discs, which were coated with TiO2-layers by sol-gel chemistry, were compared regarding their corrosion behaviour and metal ion releasing. The releasing of Al, V, Ti, Co, Cr and Mo was quantified by ICP-MS analysis. The TiO2-coating reduced the release of all ions except of the Al-ion. Both alloys showed a deviating kinetic of ion releasing. In addition, cell response (cell vitality, cell proliferation, endothelial marker CD31 and actin allocation) of osteoblasts and endothelial cells were investigated.
authors.affiliation: Friedrich-Baur-Forschungsinstitut für Biomaterialien, Universität Bayreuth, Ludwig-Thoma-Str. 36c, 95440 Bayreuth. bettina.hoffmann@fbi-biomaterialien.de
authors.forename: B
authors.initials: B
authors.lastname: Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Kokott
authors.forename: O
authors.initials: O
authors.lastname: Shafranska
authors.forename: R
authors.initials: R
authors.lastname: Detsch
authors.forename: S
authors.initials: S
authors.lastname: Winter
authors.forename: E
authors.initials: E
authors.lastname: Eisenbarth
authors.forename: K
authors.initials: K
authors.lastname: Peters
authors.forename: J
authors.initials: J
authors.lastname: Breme
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirkpatrick
authors.forename: G
authors.initials: G
authors.lastname: Ziegler
mesh_terms: D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D003343:Corrosion; D003460:Crystallization / Q000379:methods*; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008422:Materials Testing; D008670:Metals / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D044367:Phase Transition; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; D008670:Metals; C009495:titanium dioxide; D014025:Titanium