title: Long-lasting improvement of myocardial perfusion and chronic refractory angina after autologous intramyocardial PBSC transplantation.
abstract: We report the case of a 60-year-old man with patent coronary by-pass grafts on the left anterior descending and circumflex coronary arteries, who experienced recurrent Canadian class IV angina refractory to medical and interventional treatments for a dominant right coronary artery occlusion. He underwent autologous PBSC transplant into the inferior ventricular wall through a minimally invasive approach as a stand-alone therapy, in an attempt to induce therapeutic angiogenesis. Six months after the operation, angina significantly ameliorated; scintigraphy and coronary angiography showed a marked improvement in perfusion of the target injection area. These benefits had persisted at 25 months after stem cell transplant.
authors.affiliation: Research Unit for Cardiovascular Tissue Repair, Centro Cardiologico Monzino IRCCS, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pompilio
authors.forename: A
authors.initials: A
authors.lastname: Cannata
authors.forename: M
authors.initials: M
authors.lastname: Pesce
authors.forename: M C
authors.initials: MC
authors.lastname: Capogrossi
authors.forename: P
authors.initials: P
authors.lastname: Biglioli
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000628:therapy*; D017023:Coronary Angiography; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D015425:Myocardial Reperfusion; D036102:Peripheral Blood Stem Cell Transplantation; D015899:Tomography, Emission-Computed, Single-Photon