Targeting invasion induction as a therapeutic strategy for the treatment of cancer.
The spread of cancer cells from the primary tumor to a distant site involves many of the invasive processes normally required for wound healing, including migration through the local connective tissue, invasion of the vasculature, extravasation, invasion of the connective tissue at a distant site, and angiogenesis. Thus, the abilities of tumor cells to invade the host, and to induce endothelial cell invasion and neovascularization, are central to malignant progression. The plasminogen activator system, which plays a direct role in stimulating alpha5beta1 integrin fibronectin receptor-mediated invasion during wound healing, is also very important in tumor cell invasion and metastasis, as well as in angiogenesis. Therefore, the alpha5beta1 receptor and the plasminogen activator system may be promising targets for directed anticancer therapies.
Livant
Donna L
DL
Department of Radiation Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0582, USA. dlivant@umich.edu
D000818:Animals; D004358:Drug Therapy / Q000379:methods*; D006801:Humans; D039081:Integrin alpha5beta1 / Q000037:antagonists & inhibitors / Q000502:physiology; D009361:Neoplasm Invasiveness / Q000503:physiopathology / Q000517:prevention & control*; D009362:Neoplasm Metastasis / Q000503:physiopathology / Q000517:prevention & control*; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors / Q000502:physiology
D039081:Integrin alpha5beta1; D010960:Plasminogen Activators