[Graft-versus-host-like flexural eruption after autologous stem cell transplantation].
A 29-year-old man received an autologous stem cell transplantation after myeloablation with busulfan and cyclophosphamide to treat his acute myeloid leukemia, a. Five days after retransfusion of stem cells, hyperpigmented, scaly lesions with occasional perpheral lichenoid papules developed in groins, axillae, genitalia, and elbows. Histology revealed a graft-versus-host-like reaction. Although the graft-versus-host reaction, by definition, requires allogeneic cells, similar lesions have been reported after autologous stem cell transplantation. The clinical course is usually mild and self-limited. Flexural graft-versus-host-like reactions after autologous stem cell transplantation have been reported in four patients.
Riemann
Helge
H
Hautklinik, Universitätsklinikum Münster.
Thomas
Michael
M
Metze
Dieter
D
D000328:Adult; D064592:Autografts; D001365:Axilla; D001706:Biopsy; D016465:Bone Marrow Purging; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006087:Graft vs Host Reaction; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D012867:Skin / Q000473:pathology; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis* / Q000473:pathology