title: Natural products as scaffolds for chemical diversification: solution-phase parallel synthesis of a series of naringin analogues.
abstract: The flavanone glycoside naringin hydrate is widely abundant in various citrus plants. As an ongoing effort toward the exploitation of natural products as scaffolds for chemical diversification at readily accessible positions, we have prepared a series of analogues of naringin in which the 6-hydroxyl group of the beta-d-glucopyranosyl subunit was converted to sulfonamides, amides, urethanes, and secondary and tertiary amines via the corresponding 6-amino derivative using a solution-phase parallel array protocol.
authors.affiliation: Department of Chemistry, University of Montreal, P.O. Box 6128, Station Centre-Ville, Montreal, Quebec, Canada. stephen.hanessian@umontreal.ca
authors.forename: Stephen
authors.initials: S
authors.lastname: Hanessian
authors.forename: Kiran Kumar
authors.initials: KK
authors.lastname: Kothakonda