title: The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute lymphoblastic leukemia in children: an evidence-based review.
abstract: Evidence supporting the role of hematopoietic stem cell transplantation (SCT) in the therapy of acute lymphoblastic leukemia (ALL) in children is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the treatment recommendations. Treatment recommendations based on the evidence are presented in a table in this review (Summary of Treatment Recommendations Made by the Expert Panel for Pediatric Acute Lymphoblastic Leukemia) and were reached unanimously by a panel of ALL experts. The priority areas of needed future research in pediatric ALL are unrelated marrow or blood donor versus unrelated cord blood donor allogeneic SCT; alternative, nonfamily allogeneic donor versus autologous SCT; better methods for identifying high-relapse-risk patients; assessments of the effect of current chemotherapy regimens on early relapse; and use of pre-SCT detection of minimal residual disease to predict post-SCT outcomes.
authors.affiliation: Roswell Park Cancer Institute, Buffalo, New York 14263, USA. theresa.hahn@roswellpark.org
authors.forename: Theresa
authors.initials: T
authors.lastname: Hahn
authors.forename: Donna
authors.initials: D
authors.lastname: Wall
authors.forename: Bruce
authors.initials: B
authors.lastname: Camitta
authors.forename: Stella
authors.initials: S
authors.lastname: Davies
authors.forename: Hildy
authors.initials: H
authors.lastname: Dillon
authors.forename: Paul
authors.initials: P
authors.lastname: Gaynon
authors.forename: Richard A
authors.initials: RA
authors.lastname: Larson
authors.forename: Susan
authors.initials: S
authors.lastname: Parsons
authors.forename: Jerome
authors.initials: J
authors.lastname: Seidenfeld
authors.forename: Daniel
authors.initials: D
authors.lastname: Weisdorf
authors.forename: Philip L
authors.initials: PL
authors.lastname: McCarthy
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic / Q000592:standards; D019317:Evidence-Based Medicine; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000628:therapy*; D039781:PubMed; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents