Technological advances in nanoscale biomaterials: the future of synthetic vascular graft design.
Currently, autologous veins are the first choice for patients in need of bypass grafting materials. However, due to either pre-existing conditions or previous bypass surgery, some patients lack the necessary amount of host tissue for such procedures. Unfortunately, current synthetic vascular grafts of less than 6 mm in diameter have been plagued by a variety of problems. For this reason, there has been significant research aimed at finding more suitable small-diameter vascular graft materials. In order to improve vascular cell functions on such synthetic materials, several techniques are currently under development that attempt to mimic the natural nanometer architecture of the vascular basement membrane. This review presents several processes including colloidal lithography, chemical etching, electrospinning and solid free-form fabrication that could play a role in the future of vascular nanostructured biomaterial development.
Miller
Derick C
DC
Purdue University, Department of Biomedical Engineering, 500 Central Drive, West Lafayette, IN 47907-2022, USA.
Webster
Thomas J
TJ
Haberstroh
Karen M
KM
D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis / Q000009:adverse effects / Q000639:trends; D006801:Humans; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods*; D011474:Prosthesis Design / Q000639:trends*; D011475:Prosthesis Failure
D001672:Biocompatible Materials