[Study on correlation between histocompatibility leukocyte antigen class II gene and gestational diabetes mellitus].
OBJECTIVE
To investigate correlation between part of histocompatibility leukocyte antigen (HLA) class II gene and gestational diabetes mellitus (GDM).


METHODS
Part of HLA-II gene was examined by polymerase chain reaction sequence specific primer (PCR-SSP). Forty-eight GDM women were served as study group, and forty-eight normal pregnant women were selected as control group.


RESULTS
The frequencies of DRB1*0301, DRB1*1302 and DQA1*0301 of GDM (18.8%, 45.8% and 64.6%) in study group were significantly increased compared with control group (4.2%, 18.8% and 41.7%) (P < 0.05).


CONCLUSIONS
The results suggest that there is correlation between HLA class II gene and gestational diabetes mellitus. DRB1*0301, DRB1*1302 and DQA1*0301 are the susceptible alleles of GDM.
Zhao
Man-lin
ML
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China.
Feng
Yu-kun
YK
Qi
Wen-jin
WJ
D000328:Adult; D000483:Alleles; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D016017:Odds Ratio; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens