Metabotropic glutamate receptors in the basal ganglia motor circuit.
In recent years there have been tremendous advances in our understanding of the circuitry of the basal ganglia and our ability to predict the behavioural effects of specific cellular changes in this circuit on voluntary movement. These advances, combined with a new understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia, indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders.
Conn
P Jeffrey
PJ
Program in Translational Neuropharmacology, Department of Pharmacology, Vanderbilt University Medical Center, 23rd Avenue South at Pierce, 417-D Preson Research Building, Nashville, Tennessee 37232-6600, USA. jeffrey.conn@vanderbilt.edu
Battaglia
Giuseppe
G
Marino
Michael J
MJ
Nicoletti
Ferdinando
F
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D006801:Humans; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*
D018094:Receptors, Metabotropic Glutamate