title: Variants of the Klebsiella pneumoniae OKP chromosomal beta-lactamase are divided into two main groups, OKP-A and OKP-B.
abstract: Two bla(OKP) subgroups were found, diverging by 4.2%. Subgroups bla(OKP-A) (10 enzyme variants, pIs from 7.1 to 8.3) and bla(OKP-B) (11 variants, pI 7.1) showed similar antibiotic susceptibilities. Sequencing of rpoB, gyrA, and mdh demonstrated a concordant subdivision of Klebsiella pneumoniae phylogenetic group KpII into two subgroups, KpII-A and KpII-B.
authors.affiliation: Unité Biodiversité des Bactéries Pathogènes Emergentes (U389 INSERM), Institut Pasteur, 25-28 rue du Dr. Roux, 75 724 Paris Cedex 15, France.
authors.forename: Cindy
authors.initials: C
authors.lastname: Fevre
authors.forename: Virginie
authors.initials: V
authors.lastname: Passet
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Weill
authors.forename: Patrick A D
authors.initials: PA
authors.lastname: Grimont
authors.forename: Sylvain
authors.initials: S
authors.lastname: Brisse
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002876:Chromosomes, Bacterial / Q000235:genetics*; D027081:DNA Gyrase / Q000235:genetics; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D014644:Genetic Variation; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000201:enzymology / Q000235:genetics; D008291:Malate Dehydrogenase / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D008291:Malate Dehydrogenase; D001618:beta-Lactamases; D027081:DNA Gyrase