title: [Involvement of semaphorins in autoimmunity].
abstract: Semaphorins were identified originally as guidance cues for developing axons. However, it is becoming clear that several semaphorins are crucially involved in the immune system. For instance, Sema4D (CD100) enhances activation of B cells and dendritic cells, and Sema4A is involved in T cell priming and Th1/Th2 regulation. In addition, recent cumulative evidence reveals their importance in immunological homeostasis. We here focus on our current understanding of the roles of semaphorins in autoimmunity.
authors.affiliation: Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University.
authors.forename: Hyota
authors.initials: H
authors.lastname: Takamatsu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumanogoh
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D001327:Autoimmune Diseases / Q000503:physiopathology; D015551:Autoimmunity / Q000502:physiology*; D006801:Humans; D039961:Semaphorins / Q000502:physiology*
chemical_list: D015703:Antigens, CD; C093224:CD100 antigen; D039961:Semaphorins