Elevated plasma RANTES levels in patients with atopic dermatitis.
Eosinophils and T cells are involved in the pathologic process of atopic dermatitis. To further understand the role of these cells, and the possible involvement of RANTES, in the pathogenesis of atopic dermatitis, we measured the plasma level of RANTES using the sandwich ELISA. The mean plasma level of RANTES in 11 patients with atopic dermatitis was significantly higher than that of 15 normal control subjects. RANTES levels were higher in patients with severe form of atopic dermatitis than that of patients with mild disease. These findings suggest that RANTES may play a role in the recruitment and activation of eosinophils and T cells in atopic dermatitis.
Yamada
H
H
Department of Dermatology, Kinki University, Osaka, Japan.
Chihara
J
J
Matsukura
M
M
Yasuba
H
H
Yudate
T
T
Tezuka
T
T
D000293:Adolescent; D000328:Adult; D018946:Chemokine CCL5 / Q000097:blood* / Q000502:physiology; D003876:Dermatitis, Atopic / Q000097:blood*; D006801:Humans; D008875:Middle Aged
D018946:Chemokine CCL5