title: [Efficacy of tegafur/uracil plus oral leucovorin therapy for advanced or recurrent colorectal cancer].
abstract: The aim of this study was to evaluate the efficacy of tegafur/uracil (UFT) and oral Leucovorin(UZEL) in patients with advanced or recurrent colorectal cancer. Eight patients were treated with UFT/UZEL therapy as a first-line chemotherapy. UFT(300 mg/m(2)/day) and UZEL (75 mg/body/day) were administered orally for 28 consecutive days followed by a 7-day rest period, and this schedule was repeated every 5 weeks. The mean of treatment courses given to the patients was 7.6. Tumor response was evaluated in 7 patients who had assessable lesions, and the response rate was 86% (6 PR and 1 NC). Adverse reactions of grade 3 were observed in 2 patients (25%), but toxicity did not cause a discontinuance of treatment in any case. The UFT/UZEL therapy was considered to be a promising regimen for advanced or recurrent colorectal cancer from a standpoint of effect, safety and QOL of patients.
authors.affiliation: Dept. of Surgery, Matsuyama Red Cross Hospital.
authors.forename: Akira
authors.initials: A
authors.lastname: Kabashima
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Sakaguchi
authors.forename: Keishi
authors.initials: K
authors.lastname: Okita
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamamura
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Ojima
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishizaki
authors.forename: Hideya
authors.initials: H
authors.lastname: Tashiro
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Matsuzaka
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D005641:Tegafur; D014498:Uracil; D002955:Leucovorin