title: Gabapentin-induced neurologic toxicities.
abstract: Gabapentin is an antiepileptic drug approved for the treatment of postherpetic neuralgia and as adjunctive therapy for partial seizures. The drug has been shown to be safe and nontoxic. The current literature has limited reports of neurologic toxicity associated with gabapentin therapy in patients with or without renal dysfunction. We describe the case of a 75-year-old man with renal dysfunction who developed neurologic toxicity due to gabapentin accumulation. Future studies are warranted to confirm the neurologic adverse effects of gabapentin, including any additional risks in patients with renal dysfunction.
authors.affiliation: Department of Pharmaceutical Services, University of California-San Francisco, San Francisco, California 94143-0622, USA. Thomas.Bookwalter@ucsfmedctr.org
authors.forename: Thomas
authors.initials: T
authors.lastname: Bookwalter
authors.forename: Matthew
authors.initials: M
authors.lastname: Gitlin
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications; D000368:Aged; D000588:Amines / Q000009:adverse effects* / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D051474:Neuralgia, Postherpetic / Q000150:complications / Q000188:drug therapy; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin