title: Cardiovascular disease and risk factors in three Alaskan Eskimo populations: the Alaska-Siberia project.
abstract: OBJECTIVE
  To determine the prevalence of CVD and to identify and characterize associated risk factors in three distinct Eskimo populations.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  A slightly modified Strong Heart Study protocol was followed to examine 454 participants, aged 25-91, from four villages.
  
  
  RESULTS
  Overall, 6% of the participants under 55 years of age and 26% of those > or = 55 years of age showed evidence of CHD by ECG, or in patient records. The prevalence of "definite coronary heart disease" (CHD) in women with glucose intolerance (GI) was 21.0%, compared to 2.4% in those with normal glucose tolerance (NGT). Men had comparable values of 26.7% and 6.3%. In addition, comparable values for "possible CHD" were 29.7% vs 6.0% for women and 21.4% vs 8.0% for men. GI was associated with relatively higher prevalences of CHD in women than in men (prevalence ratio = 8.5 vs 4.3). CHD was significantly related to age, glucose intolerance and insulin. Hypertension and obesity were significantly associated with CHD only in some ethnic groups. The prevalence of current smokers was 56%.
  
  
  CONCLUSIONS
  Recent changes in lifestyle and diet of Alaskan Eskimos, leading to obesity, hypertension, insulin resistance and DM, contribute to an increased risk for cardiovascular disease.
authors.affiliation: Department of Neurological Surgery, University of Virginia, Charlottesville 22908-0212, USA. se6b@virginia.edu
authors.forename: Sven O E
authors.initials: SO
authors.lastname: Ebbesson
authors.forename: Amanda I
authors.initials: AI
authors.lastname: Adler
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Risica
authors.forename: Lars O E
authors.initials: LO
authors.lastname: Ebbesson
authors.forename: Jeun-Liang
authors.initials: JL
authors.lastname: Yeh
authors.forename: Oskar T
authors.initials: OT
authors.lastname: Go
authors.forename: William
authors.initials: W
authors.lastname: Doolittle
authors.forename: Gary
authors.initials: G
authors.lastname: Ehlert
authors.forename: Michael
authors.initials: M
authors.lastname: Swenson
authors.forename: David C
authors.initials: DC
authors.lastname: Robbins
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000413:Alaska / Q000453:epidemiology; D000419:Albuminuria / Q000378:metabolism; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000378:metabolism; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000208:ethnology; D007328:Insulin / Q000097:blood; D004930:Inuit / Q000706:statistics & numerical data*; D008019:Life Style; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000208:ethnology; D049629:Waist-Hip Ratio / Q000706:statistics & numerical data
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids