title: Failure of HIV-2 viral load assay in a severely immunodeficient patient: clinical and therapeutic management issues.
abstract: We report the case of an HIV-2-infected patient with severe immunosupression despite undetectable plasma HIV-2 RNA. This immunovirological discordance was due to failure of the viral load assay and infection by an unknown HIV-2 subtype. Treatment was probably suboptimal, leading to the selection of several resistance mutations and treatment failure.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184 rue du faubourg Saint-Antoine, 75012 Paris, France. laurent.fonquernie@sat.ap-hop-paris.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Fonquernie
authors.forename: Serge P
authors.initials: SP
authors.lastname: Eholié
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: Karine
authors.initials: K
authors.lastname: Lacombe
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015498:HIV-2 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood*; D017211:Treatment Failure; D019562:Viral Load / Q000379:methods / Q000592:standards
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral