title: Measuring the severity of depression and remission in primary care: validation of the HAMD-7 scale.
abstract: BACKGROUND
  Symptomatic remission is the optimal outcome in depression. A brief, validated tool for symptom measurement that can indicate when remission has occurred in mental health and primary care settings is unavailable. We evaluated a 7-item abbreviated version (HAMD-7) of the 17-item Hamilton Depression Rating Scale (HAMD-17) in a randomized controlled clinical trial of patients with major depressive disorder being cared for in primary care settings.
  
  
  METHODS
  We enrolled 454 patients across 47 primary care settings who met DSM-IV-TR criteria for a major depressive disorder. Of these, 410 patients requiring antidepressant medication were randomized to have their symptoms rated with either HAMD-7 (n = 205) or HAMD-17 (n = 205) as the primary measurement tool. The primary outcome was the proportion of patients who achieved a-priori defined responses to 8 weeks of therapy using each instrument.
  
  
  RESULTS
  Of the 205 participants per group, 67% of those evaluated with HAMD-7 were classified as having responded to therapy (defined as a > or = 50% reduction from the pretreatment score), compared with 74% of those evaluated with HAMD-17 (p = 0.43). The difference between the groups' changes in scores from baseline (pretreatment) to endpoint was significant (p < 0.001), without a main effect of group (p = 0.84) or group-by-time (p = 0.83) interaction. The HAMD-7 test was brief to administer (e.g., 3-4 min for 85% of the primary care physicians evaluated), which facilitated the efficient and structured evaluation of salient depressive symptoms.
  
  
  CONCLUSIONS
  The abbreviated HAMD-7 depression scale is equivalent to the HAMD-17 in assessing remission in patients with a major depressive disorder undergoing drug therapy.
authors.affiliation: University of Toronto, Toronto, Ont. roger.mcintyre@uhn.on.ca
authors.forename: Roger S
authors.initials: RS
authors.lastname: McIntyre
authors.forename: Jakub Z
authors.initials: JZ
authors.lastname: Konarski
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Mancini
authors.forename: Kari A
authors.initials: KA
authors.lastname: Fulton
authors.forename: Sagar V
authors.initials: SV
authors.lastname: Parikh
authors.forename: Sophie
authors.initials: S
authors.lastname: Grigoriadis
authors.forename: Larry A
authors.initials: LA
authors.lastname: Grupp
authors.forename: David
authors.initials: D
authors.lastname: Bakish
authors.forename: Marie-Josee
authors.initials: MJ
authors.lastname: Filteau
authors.forename: Chris
authors.initials: C
authors.lastname: Gorman
authors.forename: Charles B
authors.initials: CB
authors.lastname: Nemeroff
authors.forename: Sidney H
authors.initials: SH
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000145:classification* / Q000523:psychology / Q000628:therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011320:Primary Health Care; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D016896:Treatment Outcome