Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens.
The recent development of T cell receptor phage display opens up the possibility of engineering human T cell receptors with antibody-like binding properties for cell-surface peptide antigens. In this review we briefly discuss recent developments in molecular targeting of peptide antigens. We then discuss potential clinical applications of engineered high-affinity T cell receptors in autoimmunity and cancer.
Boulter
J M
JM
Department of Medical Biochemistry and Immunology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, UK. BoulterJM@Cardiff.ac.uk
Jakobsen
B K
BK
D000906:Antibodies / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000915:Antibody Affinity / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D001435:Bacteriophages / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008285:Major Histocompatibility Complex / Q000276:immunology; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D010455:Peptides / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000941:Antigens; D010455:Peptides; D011948:Receptors, Antigen, T-Cell