[Significance of serum PTH (7-84) as a reliable nutritional marker in hemodialysis patients].
To evaluate the significance of serum PTH (7-84) in hemodialysis patients, correlation of the serum PTH (7-84) level with various nutritional markers was investigated in HD patients. Serum PTH was determined in 170 male HD patients by either a Bio intact PTH assay or a second-generation intact PTH assay. The level of bone formation markers and bone resorption markers were also measured. Lean body mass in trunk region was measured by dual X-ray absorptiometry. The serum PTH (7-84) level was obtained for the difference between serum I-PTH and Bio-PTH. Serum PTH (1-84) was directly obtained from the serum Bio-PTH value. Serum PTH (7-84) correlated significantly with nutritional markers such as body weight, albumin, PCR, TAC BUN, BUN, phosphate and lean body mass in trunk, whereas PTH (1-84) only correlated with phosphate. The correlation of serum PTH (7-84) with bone metabolic markers was no less significant than that for PTH (1-84). The results suggest that serum level of PTH (7-84) may provide clinically useful information, not only of the bone metabolic state but also of the nutritional state in HD patients, in sharp contrast to the exclusive correlation of PTH (1-84) with bone metabolic state.
Shidara
Kaori
K
Department of Metabolism Endocrinology Molecular Medicine, Osaka City University Graduate School of Medicine.
Inaba
Masaaki
M
Kumeda
Yasuro
Y
Imanishi
Yasuo
Y
Tahara
Hideki
H
Ishimura
Eiji
E
Nishizawa
Yoshiki
Y
Yamakawa
Tomoyuki
T
Okuno
Senji
S
D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism; D006801:Humans; D008297:Male; D009752:Nutritional Status; D010281:Parathyroid Hormone / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D006435:Renal Dialysis
D015415:Biomarkers; D010281:Parathyroid Hormone; D010446:Peptide Fragments; C414937:parathyroid hormone (7-84)