Comparative efficacy of Rubini, Jeryl-Lynn and Urabe mumps vaccine in an Asian population.
OBJECTIVE
The comparative efficacy of the three mumps vaccine strains (Jeryl-Lynn, Urabe and Rubini) was conducted in an Asian population from data arising from an epidemiological investigation of seven institutional outbreaks of mumps in Singapore.


METHODS
Demographic information (gender, age, ethnic group), clinical presentation and vaccination history (date and place of mumps vaccination, type of mumps vaccine received) of all children who attended the six childcare centres and one primary school where outbreaks of 20 or more cases of mumps occurred in 1999 were collected. The attack rate of the unvaccinated group and the attack rates of the vaccine groups (for each vaccine strain) were determined and the vaccine efficacy of the three vaccines calculated.


RESULTS
The vaccine efficacy of the Jeryl-Lynn strain, Urabe strain and Rubini strain mumps vaccine were 80.7, 54.4 and -55.3%, respectively.


CONCLUSIONS
Rubini strain mumps vaccine conferred no protection and has since been deregistered in Singapore.
Ong
Gary
G
Division of Epidemiology and Disease Control, Ministry of Health, College of Medicine Building, 16 College Road, Singapore 169854, Singapore. gary_ong@moh.gov.sg
Goh
Kee Tai
KT
Ma
Stefan
S
Chew
Suok Kai
SK
D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000517:prevention & control; D006801:Humans; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology / Q000592:standards; D009107:Mumps / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D009108:Mumps Vaccine / Q000276:immunology / Q000592:standards*; D009109:Mumps virus / Q000145:classification* / Q000276:immunology; D018571:Sentinel Surveillance; D012703:Serotyping; D012846:Singapore / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome; D017778:Vaccines, Combined / Q000276:immunology / Q000592:standards
D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D017778:Vaccines, Combined