title: Value of preoperative serum CA125 in early-stage adenocarcinoma of the uterine cervix without pelvic lymph node metastasis.
abstract: OBJECTIVE
  This investigation attempted to clarify the value of preoperative serum CA125 in predicting histopathological prognostic factors for early-stage cervical adenocarcinoma without lymph node metastasis.
  
  
  METHODS
  This study initially surveyed 163 patients with clinical stage Ib or IIa cervical adenocarcinoma treated with radical hysterectomy and pelvic lymphadenectomy. Of the 163 patients, 116 had preoperative serum CA125 levels, and 14 had pelvic lymph node metastasis. The investigation group comprised 102 lymph node-negative patients.
  
  
  RESULTS
  A cutoff value of 26 U/ml was obtained after the discriminant function analysis for identifying patients with positive lymph vascular space invasion (LVSI) or depth of stromal invasion > or =2/3 thickness. Multivariate analysis revealed that among the preoperative clinicopathological variables, including age, tumor size, parametrial invasion, and CA125 level, raised CA125 most significantly influenced the assessment of the LVSI (P = 0.040) and depth of cervical stromal invasion (P = 0.002).
  
  
  CONCLUSIONS
  In early-stage cervical adenocarcinoma with negative pelvic lymph node metastasis, preoperative serum CA125 levels at the cutoff value of 26 U/ml impacted the determination of the poor histopathological prognostic factors.
authors.affiliation: Department of Gynecologic Oncology, Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, ROC, Taiwan.
authors.forename: Ching-Chou
authors.initials: CC
authors.lastname: Tsai
authors.forename: Yi-Shan
authors.initials: YS
authors.lastname: Liu
authors.forename: Eng-Yen
authors.initials: EY
authors.lastname: Huang
authors.forename: Shun-Chen
authors.initials: SC
authors.lastname: Huang
authors.forename: Hsueh-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Chih-Weng
authors.initials: CW
authors.lastname: Tseng
authors.forename: Chan-Chao
authors.initials: CC
authors.lastname: ChangChien
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology*; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology*
chemical_list: D018394:CA-125 Antigen