Multiple emulsion stability: pressure balance and interfacial film strength.
The objective of this study was to investigate the significance of inner and outer phase pressure, as well as interfacial film strength on W/O/W multiple emulsion stability using microscopy and long-term stability tests. It was observed that immediately upon applying a coverslip to samples the multiple droplets deformed and there was coalescence of the inner aqueous droplets. Under certain conditions (such as lipophilic surfactant concentration and internal phase osmotic pressure) the destabilized multiple emulsions formed unique metastable structures that had a "dimpled" appearance. The formation of these metastable structures correlated with the real-time instability of the W/O/W multiple emulsions investigated. Multiple emulsion stability also correlated with the interfacial film strength (measured by interfacial elasticity) of the hydrophobic surfactant at the mineral oil/external continuous aqueous phase interface. The formation of the metastable dimpled structures and the long-term stability of the multiple emulsions were dependent on the osmotic pressure of the inner droplets and the Laplace curvature pressure as described by the Walstra Equation (P. Walstra, "Encyclopedia of Emulsion Technology" (P. Becher, Ed.), Vol. 4. Dekker, New York, 1996). It appears that the effect of coverslip pressure on multiple emulsions may be useful as an accelerated stability testing method or for initial formulation screening.
Jiao
Jim
J
School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA.
Rhodes
David G
DG
Burgess
Diane J
DJ
D004355:Drug Stability; D004548:Elasticity; D004655:Emulsions / Q000737:chemistry*; D008853:Microscopy; D008899:Mineral Oil / Q000737:chemistry; D009997:Osmotic Pressure; D011136:Polysorbates / Q000737:chemistry; D011312:Pressure; D013500:Surface Tension / Q000187:drug effects; D014867:Water / Q000737:chemistry
D004655:Emulsions; D011136:Polysorbates; D014867:Water; D008899:Mineral Oil