title: [Application of double-filtration plasmapheresis in major ABO-incompatible unrelated bone marrow transplantation].
abstract: OBJECTIVE
  To evaluate the effect of double-filtration plasmapheresis (DFPP) in major ABO-incompatible unrelated allogenic bone marrow transplantation.
  
  
  METHODS
  The red cell antibodies were removed by DFPP in 5 recipients to prevent hemolysis and pure red cell aplasia following major ABO-incompatible unrelated bone marrow transplantation.
  
  
  RESULTS
  The isohemagglutinin titers of the 5 recipients were below 1:16 after DFPP with only one recipient developed transient mild acute hemolysis. Delayed hemolysis and pure red cell aplasia occurred in none of the cases and all recipients were completely engrafted.
  
  
  CONCLUSIONS
  DFPP can effectively prevent hemolysis and pure red cell aplasia in recipients of unrelated bone marrow transplantation with major ABO-incompatibility.
authors.affiliation: Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. aoyunhui@fimmu.com
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Qi-fa
authors.initials: QF
authors.lastname: Liu
authors.forename: Fang-yi
authors.initials: FY
authors.lastname: Men
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D001787:Blood Group Incompatibility; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology; D005260:Female; D005374:Filtration; D006461:Hemolysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D012010:Red-Cell Aplasia, Pure / Q000517:prevention & control; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000276:immunology / Q000379:methods
chemical_list: D000017:ABO Blood-Group System