[Differential expression of human macrophage genes encoding cytokines and their regulatory elements after Mycobacterium tuberculosis infection].
To investigate whether the genes encoding cytokines and their regulatory elements participated in the immune response to Mycobacterium tuberculosis infection. Expression microarray was employed to compare the avirulent strain and clinically isolated strains infection induced macrophage cytokine differential expression. Results were cytokines IFN, TNF, TGF, IL and their regulatory elements are involved in the immune reaction. IL-19 was first reported to be involved in the anti-Mtb immunity. Relative expression level of theses factors before and after infection were assayed too. The data provides clues for further scrutinize the role of cytokines and related elements in the interaction between Mycobacterium tuberculosis and host macrophage.
Xie
Jianping
J
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China. jianpingxie@vip.sina.com
Li
Yao
Y
Yue
Jun
J
Xu
Yongzhong
Y
Wang
Honghai
H
Liang
Li
L
Yu
Shanqian
S
Hu
Changhua
C
D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D015870:Gene Expression; D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity / Q000502:physiology*; D050436:Regulatory Elements, Transcriptional; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D020298:U937 Cells; D014774:Virulence
D016207:Cytokines