Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders.
Natural killer (NK) lymphoma in Asia is frequently associated with latent Epstein-Barr (EBV) infection. Unlike the adult cases, EBV-associated NK/T cell lymphomas in children are often preceded by various EBV-related disorders, including chronic active EBV infection (CAEBV), hypersensitivity to mosquito bites (HMB), virus-associated haemophagocytic syndrome (VAHS), and hydroa vacciniforme (HV)-like eruptions. Here, we report a 14-year-old Japanese girl who sequentially developed all the symptoms related to EBV-associated NK/T cell lymphoproliferative disorders in a 12-year clinical course. Our observations confirm the spectrum of EBV-associated cutaneous disorders and indicate the importance of long-term follow-up.
Nitta
Yukiko
Y
Department of Dermatology, National Hospital Organization Nagoya Medical Center, Nagoya 460-0001, Japan.
Iwatsuki
Keiji
K
Kimura
Hiroshi
H
Kojima
Seiji
S
Morishima
Tsuneo
T
Tsuji
Kazuhide
K
Oono
Takashi
T
D000293:Adolescent; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007694:Killer Cells, Natural; D008223:Lymphoma / Q000209:etiology*