title: Stroke-in-evolution: infarct-inherent mechanisms versus systemic causes.
abstract: BACKGROUND
  It is uncertain whether deterioration after acute ischemic stroke is neurological and/or systemic (somatic) in origin.
  
  
  METHODS
  442 consecutive patients admitted with first-ever ischemic stroke (FIS) were assessed by the Unified Neurological Stroke Scale (UNSS) at admission, on hospitalization days 1, 2 and 3 and before discharge.
  
  
  RESULTS
  Among 71/442 (16.1%) patients deteriorated during hospitalization, the worsening from stroke onset was early (<or=72 h) in 67 (94.4%) of them. The majority (57/71, 80.3%) had CT-confirmed cerebral causes and 14/71 (19.7%) had systemic causes. The causes of late deterioration were exclusively systemic. In the logistic regression analysis the initial mean UNSS score was the only significant independent predictor of stroke deterioration (p < 0.0001).
  
  
  CONCLUSIONS
  Early clinical deterioration in FIS patients results from infarct-inherent mechanisms while late stroke deterioration is due primarily to systemic factors. An initially severe neurological deficit might predict further decline.
authors.affiliation: Stroke Unit, Department of Neurology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Vadim G
authors.initials: VG
authors.lastname: Karepov
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Gur
authors.forename: Irina
authors.initials: I
authors.lastname: Bova
authors.forename: Boris D
authors.initials: BD
authors.lastname: Aronovich
authors.forename: Natan M
authors.initials: NM
authors.lastname: Bornstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000150:complications; D020520:Brain Infarction / Q000150:complications* / Q000000981:diagnostic imaging; D002318:Cardiovascular Diseases / Q000150:complications; D018450:Disease Progression; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications; D011446:Prospective Studies; D011859:Radiography; D012720:Severity of Illness Index; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology*; D013997:Time Factors