Strain improvement studies on production of cephalosporin C from Acremonium chrysogenum ATCC 48272.
Strain development for antibiotic production has been an essential prerequistie for efficient production process. Studies were carried out to produce high antibiotic yield strain by using UV and N-methyl-N1-nitro-nitrosoguanidine (NTG) as mutagens. A superior mutant (PNTG-22) with a productivity of 2.4 time (810-1995 microg/ml higher than, the parent strain was produced.
Ellaiah
P
P
Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh 530 003, India.
Kumar
J Prem
JP
Saisha
V
V
Sumitra
J J
JJ
Vaishali
P
P
D000164:Acremonium / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D002511:Cephalosporins / Q000096:biosynthesis*; D009154:Mutation; D013056:Spectrophotometry, Ultraviolet; D013172:Spores, Fungal / Q000737:chemistry
D002511:Cephalosporins; C025163:cephalosporin C