title: Structure and intermolecular interactions of glipizide from laboratory X-ray powder diffraction.
abstract: The crystal structure of glipizide, used as a major treatment of type-2 diabetes, has been determined ab initio using variable-temperature laboratory X-ray powder diffraction combined with a direct-space Monte Carlo/simulated annealing methodology. The strengths of the intermolecular interactions (van der Waals, pi-pi stacking, hydrogen bonding and steric interlock) were quantitatively estimated using the thermal expansion data, which were collected in the same set of experiments as those used to determine the structure.
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, England. jb442@cam.ac.uk
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Burley
mesh_terms: D018360:Crystallography, X-Ray; D005913:Glipizide / Q000737:chemistry*; D006860:Hydrogen Bonding; D007004:Hypoglycemic Agents / Q000737:chemistry*; D011208:Powders
chemical_list: D007004:Hypoglycemic Agents; D011208:Powders; D005913:Glipizide