Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.
The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target.
Gokhale
Nikhil H
NH
Department of Chemistry, University of Pune, Ganeshkhind Road, Pune-411007, India.
Shirisha
K
K
Padhye
Subhash B
SB
Croft
Simon L
SL
Kendrick
Howard D
HD
Mckee
Vickie
V
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D009285:Naphthoquinones; D009942:Organometallic Compounds; D003300:Copper