Toxicity bioassay in Sprague-Dawley rats exposed to 20 kHz triangular magnetic field for 90 days.
Sprague-Dawley rats (10 each of male and female per group for sham and magnetic field exposed) were exposed in a carrousel irradiator to 20 kHz intermediate frequency (IF) magnetic field at 6.25 microT rms for 8 h/day, 5 days/week for 90 days. Urine analysis (pH, serum glucose, protein, ketone bodies, RBC, WBC, bilirubin, urobilinogen, and specific gravity), blood analysis [WBC, RBC, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), thrombocyte count, and leucocyte count], blood biochemistry (total protein, blood urea nitrogen, creatinine, glucose, total bilirubin, total cholesterol, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase), and histopathological analysis for organs such as liver, kidney, testis, ovary, spleen, brain, heart, and lung were performed on day 90. Results showed no significant differences in the above analyses between IF magnetic field exposed and sham control rats. Therefore, we conclude that there were no significant toxicities in rats exposed to 20 kHz IF triangular magnetic field-exposure for 90 days.
Kim
Sung-Ho
SH
College of Veterinary Medicine, Chonnam National University, Kwangju, Korea.
Lee
Hae-June
HJ
Choi
Soo-Yong
SY
Gimm
Youn-Myoung
YM
Pack
Jeong-Ki
JK
Choi
Hyung-Do
HD
Lee
Yun-Sil
YS
D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D008297:Male; D009929:Organ Size / Q000528:radiation effects; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology* / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate; D018675:Toxicity Tests; D014916:Whole-Body Irradiation / Q000009:adverse effects*