title: A novel formulation for blood trauma prediction by a modified power-law mathematical model.
abstract: With the increasing use of artificial organs, blood damage has been raising ever more clinical concern. Blood trauma is in fact a major complication resulting from the implantation of medical devices and the use of life support apparatuses. Red blood cells damage predictive models furnish critical information on both the design and the evaluation of artificial organs, because their correct usage and implementation are thought to provide clear and rational guidance for the improvement of safety and efficacy. The currently adopted power-law shear-induced haemolysis prediction model lacks sensitivity with respect to the cumulative effect of previously applied stress magnitudes. An alternative model is proposed where a mechanical quantity was defined, able to describe the blood damage sustained by red cells under unsteady stress conditions, taking into account the load history. The proposed formulation predicted the same trend as the available experimental data. The obtained results have to be considered a preliminary validation of the basic hypothesis of this modified red blood cell damage prediction model. To date, the necessity to design further experiments to validate the proposed damage function clashes with the limitations inherent to current systems to get the time-varying shear stress completely under control.
authors.affiliation: Cardiovascular Bioengineering Unit, Technology and Health Department, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. grigioni@iss.it
authors.forename: Mauro
authors.initials: M
authors.lastname: Grigioni
authors.forename: Umberto
authors.initials: U
authors.lastname: Morbiducci
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Avenio
authors.forename: Giacomo Di
authors.initials: GD
authors.lastname: Benedetto
authors.forename: Costantino
authors.initials: C
authors.lastname: Del Gaudio
mesh_terms: D000465:Algorithms; D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002478:Cells, Cultured; D003198:Computer Simulation; D004548:Elasticity; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical