title: Causes and outcomes of pouch excision after restorative proctocolectomy.
abstract: BACKGROUND
  Pouch failure occurs in up to 10 per cent of patients after ileal pouch-anal anastomosis (IPAA). The aims of this study were to determine the reasons for pouch excision and to evaluate the outcome of the perineal wound after pouch excision.
  
  
  METHODS
  Between 1984 and 2002, 91 patients with severe ileal pouch dysfunction were treated. This was a retrospective analysis of data collected prospectively from 24 patients who underwent pouch excision.
  
  
  RESULTS
  Patients were grouped according to the final histological diagnosis. Fourteen patients with Crohn's disease developed extensive fistulous disease and/or recurrent abscesses, of whom six had a persistent perineal sinus after pouch excision. Five patients had familial adenomatous polyposis, in three of whom desmoid tumours were the cause of failure. Three patients had chronic ulcerative colitis and developed recurrent pelvic sepsis. Finally, two patients with multiple colorectal adenocarcinoma developed recurrent cancer (one) or sepsis (one).
  
  
  CONCLUSIONS
  Sepsis was the principal reason for pouch excision and was usually associated with recrudescent Crohn's disease in the pouch. Perineal wound healing was problematic after pouch excision for Crohn's disease.
authors.affiliation: Department of Digestive Surgery, Hôpital Saint-Antoine, 184 Rue du Faubourg Saint-Antoine, 75012 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Prudhomme
authors.forename: N
authors.initials: N
authors.lastname: Dehni
authors.forename: R R
authors.initials: RR
authors.lastname: Dozois
authors.forename: E
authors.initials: E
authors.lastname: Tiret
authors.forename: R
authors.initials: R
authors.lastname: Parc
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003093:Colitis, Ulcerative / Q000601:surgery; D003110:Colonic Neoplasms / Q000601:surgery; D039021:Colonic Pouches; D003424:Crohn Disease / Q000601:surgery; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000379:methods*; D012008:Recurrence; D016896:Treatment Outcome; D014945:Wound Healing