Urinary disease in 2 Dogon populations with different exposure to Schistosoma haematobium infection: progression of bladder and kidney diseases in children and adults.
BACKGROUND
Schistosoma haematobium infection causes severe urinary disease and considerable mortality. The factors that determine disease progression from mild to severe stages are not fully understood.


METHODS
Here we describe a cross-sectional epidemiological study of kidney and bladder diseases in 2 Dogon populations with different exposure to S. haematobium infection.


RESULTS
Early and high exposure resulted in more-severe disease, especially among young subjects, without clear evidence of a more-rapid development of immunity. Nevertheless, 50%-60% of subjects of all age classes in both villages showed no evidence of disease. Kidney and bladder disease peaked biphasically among young subjects and adults >25 years old. The first peak corresponded with infections of maximum intensity, whereas the second peak occurred among adults with infections of very low intensity. Kidney disease was correlated with circulating anodic antigen concentration in serum, whereas bladder disease was correlated with egg count and eosinophil cationic protein concentration in urine. Kidney and bladder disease did not correlate. Severe kidney disease was more frequent in certain families.


CONCLUSIONS
The frequency of urinary disease is increased by infections acquired early during life, is regulated by strong clinical immunity in certain subjects, and may be dependent on hereditary factors. Kidney and bladder disease may involve different mechanisms of pathogenesis, which may differ between children and adults.
Kouriba
Bourema
B
Department of Epidemiology and Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, University of Bamako, Mali.
Traore
Hamar A
HA
Dabo
Abdoulaye
A
Sangare
Lansana
L
Guindo
Hamadoun
H
Keita
Abdoul Salam
AS
Reimert
Claus M
CM
van Dam
Govert J
GJ
Deelder
Andre M
AM
Doumbo
Ogobara
O
Dessein
Alain J
AJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D047150:Eosinophil Cationic Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000469:parasitology / Q000503:physiopathology*; D008297:Male; D008302:Mali / Q000453:epidemiology; D010270:Parasite Egg Count; D015995:Prevalence; D012548:Schistosoma haematobium / Q000502:physiology; D012553:Schistosomiasis haematobia / Q000453:epidemiology / Q000503:physiopathology*; D012737:Sex Factors; D013223:Statistics as Topic; D001745:Urinary Bladder Diseases / Q000453:epidemiology / Q000469:parasitology / Q000503:physiopathology*; D014556:Urine / Q000737:chemistry
D000947:Antigens, Helminth; D047150:Eosinophil Cationic Protein