title: Toward the clinical application of time-domain fluorescence lifetime imaging.
abstract: High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed.
authors.affiliation: Imperial College London, Physics Department, Photonics Group, South Kensington Campus, London SW7 2AZ. i.munro@imperial.ac.uk
authors.forename: I
authors.initials: I
authors.lastname: Munro
authors.forename: J
authors.initials: J
authors.lastname: McGinty
authors.forename: N
authors.initials: N
authors.lastname: Galletly
authors.forename: J
authors.initials: J
authors.lastname: Requejo-Isidro
authors.forename: P M P
authors.initials: PM
authors.lastname: Lanigan
authors.forename: D S
authors.initials: DS
authors.lastname: Elson
authors.forename: C
authors.initials: C
authors.lastname: Dunsby
authors.forename: M A A
authors.initials: MA
authors.lastname: Neil
authors.forename: M J
authors.initials: MJ
authors.lastname: Lever
authors.forename: G W H
authors.initials: GW
authors.lastname: Stamp
authors.forename: P M W
authors.initials: PM
authors.lastname: French
mesh_terms: D000818:Animals; D003199:Computer Systems; D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D051379:Mice; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D018715:Microscopy, Video / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity