title: Memory mechanisms of active transcription during cell division.
abstract: The developmental programs of eukaryotic organisms involve the programmed transcription of genes. A characteristic gene expression pattern is established and preserved in each different cell type. Therefore, gene activation at a particular time and its maintenance during cell division are significant for cellular differentiation and individual development. Although many studies have sought to explain the molecular mechanisms of gene expression regulation, the mechanism through which gene expression states are inherited during cell division has not been fully elucidated yet. This review illustrates the general principles and the complexities involved in the establishment and maintenance of active transcription through cell cycles. It focuses on the most-recent findings about the ways in which molecular memory marks for active transcription are coordinated with cell cycle events, such as replication, mitosis and nuclear organization, to mediate transcription memory across cell division events, which may establish a unifying memory process of active transcription.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R.China.
authors.forename: Guo-Ling
authors.initials: GL
authors.lastname: Zhou
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Liu
authors.forename: Chih-Chuan
authors.initials: CC
authors.lastname: Liang
mesh_terms: D000818:Animals; D002455:Cell Division; D002875:Chromosomes / Q000235:genetics; D004261:DNA Replication; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D014158:Transcription, Genetic / Q000235:genetics* / Q000502:physiology*; D015533:Transcriptional Activation