title: Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.
abstract: The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target.
authors.affiliation: Department of Chemistry, University of Pune, Ganeshkhind Road, Pune-411007, India.
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Gokhale
authors.forename: K
authors.initials: K
authors.lastname: Shirisha
authors.forename: Subhash B
authors.initials: SB
authors.lastname: Padhye
authors.forename: Simon L
authors.initials: SL
authors.lastname: Croft
authors.forename: Howard D
authors.initials: HD
authors.lastname: Kendrick
authors.forename: Vickie
authors.initials: V
authors.lastname: Mckee
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D009285:Naphthoquinones; D009942:Organometallic Compounds; D003300:Copper