title: Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica.
abstract: Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica (NMO) (17%) but in none of 130 cases of multiple sclerosis (MS). IHN resolved with methylprednisolone. In six cases, MRI detected linear medullary lesions involving the pericanal region, the area postrema, and the nucleus tractus solitarius. Like long and centrally located myelitis, a linear medullary lesion causing IHN may distinguish NMO from MS.
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan. misu@em.neurol.med.tohoku.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Misu
authors.forename: K
authors.initials: K
authors.lastname: Fujihara
authors.forename: I
authors.initials: I
authors.lastname: Nakashima
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Itoyama
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D031608:Area Postrema / Q000473:pathology / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006606:Hiccup / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis; D009325:Nausea / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D009471:Neuromyelitis Optica / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012008:Recurrence; D012189:Retrospective Studies; D017552:Solitary Nucleus / Q000473:pathology / Q000503:physiopathology; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology; D014630:Vagus Nerve / Q000473:pathology / Q000503:physiopathology; D017833:Visceral Afferents / Q000473:pathology / Q000503:physiopathology*