[Genome analysis and cancer therapy].
Application of the human genome information would lead to the development of novel diagnostic methods and innovative therapies against cancer. In this article, two aspects of such application are reviewed; 1) genomic diagnosis for predicting efficacy and side effects associated with the administration of the anti-cancer drugs, 2) exploration of novel cancer associated gene products using genome-wide gene-expression profiling. Successful examination on genetic information of the patients/tumors would lead to the establishment of the "personalized" medicine which could be an ideal situation for the cancer patients treated with the chemotherapeutic drugs. Furthermore, the finding of tumor associated antigens lead to the development of not only new diagnostic methods but also novel therapeutic modalities including cancer vaccine. Some of the successful efforts are referred and discussed.
Tahara
Hideaki
H
Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Japan.
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide
D000970:Antineoplastic Agents