title: Cardiorenal consequences of atherosclerosis and statins therapy: from the past to the future.
abstract: Complications from atherosclerosis cause most deaths in western countries, and their incidence appears to be markedly increasing in developing countries, thus suggesting a correlation that is directly proportional to social progress. In recent years, the different branches of medical research, from studies on vascular disease to those on lipid and glucose metabolism, and also clinical research on coronary, carotid and peripheral artery diseases, epidemiologic and pharmacologic research, have concentrated on these diseases with the common aim of reducing the incidence of cardiovascular diseases, and mortality. Scientific progress has greatly improved our understanding of the pathogenic mechanisms underlying the progression of cardiovascular disease, and efforts in this discipline now appear more necessary than ever.
authors.affiliation: Chair of Nephrology, Department of Internal Medicine, Messina, Italy. buemim@Unime.it
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
authors.forename: Carmela
authors.initials: C
authors.lastname: Aloisi
authors.forename: Floccari
authors.initials: F
authors.lastname: Fulvio
authors.forename: Chiara
authors.initials: C
authors.lastname: Caccamo
authors.forename: Emanuela
authors.initials: E
authors.lastname: Cavallaro
authors.forename: Eleonora
authors.initials: E
authors.lastname: Crascì
authors.forename: Manila
authors.initials: M
authors.lastname: Criseo
authors.forename: Francesco
authors.initials: F
authors.lastname: Corica
authors.forename: Nicola
authors.initials: N
authors.lastname: Frisina
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy* / Q000473:pathology*; D016723:Bone Remodeling / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use; D007249:Inflammation / Q000473:pathology; D009129:Muscle Tonus / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051437:Renal Insufficiency / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007155:Immunologic Factors