[Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats].
OBJECTIVE
To observe the effect of ginseng fruit saponins (GFS) on insulin sensitivity index in high fat-fed rats.


METHODS
An animal model of insulin resistance was established by injecting low dose of streptozotocin (STZ) in high fat-fed rats. Effect of GFS on insulin sensitivity was detected with glucose infusion rate (GIR) by euglycemic hyperinsulinemic clamp technique.


RESULTS
The level of fasting blood glucose and insulin in untreated group increased more significantly than that in normal control group (P<0.05, P<0.01), while the index of GIR decreased significantly (P<0.01). As compared with the untreated groupìthe parameters of GFS-treated groups were improved significantly in a dosage-dependent manner (P<0.05, P<0.01).


CONCLUSIONS
GFS can improve experimental insulin resistance in rats.
Luo
Lan
L
Department of Cardiovascular Diseases, Medical College, Jiamusi University, Jiamusi, Heilongjiang Province 154007, China.
Yin
Hui-Jun
HJ
Zhang
Ying
Y
Jiang
Yue-Rong
YR
Liu
Ying
Y
Shi
Da-Zhuo
DZ
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004041:Dietary Fats; D005638:Fruit / Q000737:chemistry; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D005894:Panax / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D012503:Saponins