title: Novel endoperoxides: synthesis and activity against Candida species.
abstract: Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.
authors.affiliation: CSIRO, Molecular and Health Technologies, Parkville, 3052 Victoria, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Macreadie
authors.forename: Thomas
authors.initials: T
authors.lastname: Avery
authors.forename: Ben
authors.initials: B
authors.lastname: Greatrex
authors.forename: Dennis
authors.initials: D
authors.lastname: Taylor
authors.forename: Ian
authors.initials: I
authors.lastname: Macreadie
mesh_terms: D002175:Candida / Q000145:classification* / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D013237:Stereoisomerism
chemical_list: D010545:Peroxides