Immunohistochemical staining of hedgehog pathway-related proteins in human thymomas.
The thymus plays an essential role in the maturing of progenitor cells to functional T cells. Recent studies suggest that the Hedgehog (Hh) signaling pathway contributes to this differentiation process. However, there is limited information concerning the expression of Hh pathway-related proteins (Hh proteins) in the human thymus. The staining of Hh proteins in the thymic epithelium of 26 surgically resected thymoma tissues was examined by immunohistochemistry. The staining of sonic Hh (Shh) correlated relatively well with the World Health Organization histological classification of thymoma. The higher the grade, the fainter the staining. However, no significant difference in Shh staining was found between normal and neoplastic epithelia. Interestingly, Gli1 staining in thymomas was significantly greater than that in normal thymus (p < 0.0001). Thus, some members of the Hh signaling pathway may contribute to the development of thymoma.
Tasaki
Akira
A
Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akiyoshi
Takashi
T
Koga
Kenichiro
K
Nakashima
Hiroshi
H
Yamanaka
Naoki
N
Kubo
Makoto
M
Matsumoto
Kotaro
K
Kojima
Masayuki
M
Tanaka
Masao
M
Nakamura
Masafumi
M
Katano
Mitsuo
M
D000328:Adult; D004848:Epithelium / Q000378:metabolism; D005260:Female; D053823:Hedgehog Proteins; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013945:Thymoma / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D013950:Thymus Gland / Q000378:metabolism; D015534:Trans-Activators / Q000096:biosynthesis*
D053823:Hedgehog Proteins; C509239:SHH protein, human; D015534:Trans-Activators