title: Four unusual two-component signal transduction homologs, RedC to RedF, are necessary for timely development in Myxococcus xanthus.
abstract: We identified a cluster of four two-component signal transduction genes that are necessary for proper progression of Myxococcus xanthus through development. redC to redF mutants developed and sporulated early, resulting in small, numerous, and disorganized fruiting bodies. Yeast two-hybrid analyses suggest that RedCDEF act in a single signaling pathway. The previously identified espA gene displays a phenotype similar to that of redCDEF. However, combined mutants defective in espA redCDEF exhibited a striking additive developmental phenotype, suggesting that EspA and RedC to RedF play independent roles in controlling developmental progression.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3204, USA.
authors.forename: Penelope I
authors.initials: PI
authors.lastname: Higgs
authors.forename: Kyungyun
authors.initials: K
authors.lastname: Cho
authors.forename: David E
authors.initials: DE
authors.lastname: Whitworth
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Evans
authors.forename: David R
authors.initials: DR
authors.lastname: Zusman
mesh_terms: D000595:Amino Acid Sequence; D005798:Genes, Bacterial; D000071677:Histidine Kinase; D008969:Molecular Sequence Data; D005810:Multigene Family; D009154:Mutation; D016941:Myxococcus xanthus / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D011494:Protein Kinases / Q000235:genetics; D016415:Sequence Alignment; D015398:Signal Transduction / Q000235:genetics*; D013170:Spores / Q000254:growth & development
chemical_list: D011494:Protein Kinases; D000071677:Histidine Kinase