Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation.
The clinical significance of human herpesvirus (HHV-6) infections after allogeneic stem cell transplantation (SCT) remains controversial. We analysed cryoconserved plasma samples from 82 patients after allogeneic SCT by quantitative polymerase chain reaction for HHV-6 variants A and B. Platelet engraftment was delayed in patients with HHV-6B infections but not with HHV-6A infections detected before day +28. In multivariate analysis early HHV-6B infections and the type of conditioning were associated with platelet engraftment. In conclusion, the two variants of HHV-6 should be studied separately; early infections with HHV-6B may contribute to delayed platelet engraftment after allogeneic SCT.
Radonić
Aleksandar
A
Medizinische Klinik II mit Schwerpunkt Onkologie und Hämatologie, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Oswald
Olivia
O
Thulke
Stefanie
S
Brockhaus
Nina
N
Nitsche
Andreas
A
Siegert
Wolfgang
W
Schetelig
Johannes
J
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000821:virology; D018380:Hematopoietic Stem Cell Transplantation; D015654:Herpesvirus 6, Human / Q000145:classification* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012189:Retrospective Studies; D019349:Roseolovirus Infections / Q000097:blood* / Q000150:complications / Q000821:virology; D019172:Transplantation Conditioning / Q000379:methods
D004279:DNA, Viral