title: The effect of early intervention with sumatriptan tablets on migraine-associated productivity loss.
abstract: OBJECTIVE
  Impaired performance, which can considerably impact employee output, occurs when employees attempt to continue work with inadequate treatment while experiencing a migraine episode. This analysis examined productivity loss as a result of migraine after treatment with sumatriptan tablets and patients' usual non-triptan therapy when pain was mild (early intervention) versus when pain was moderate/severe.
  
  
  METHODS
  The authors conducted a retrospective analysis of data on 6803 migraine days reported by 251 subjects who participated in a clinical trial.
  
  
  RESULTS
  Although early intervention significantly reduced productivity loss compared with treatment when pain was moderate/severe for both sumatriptan and non-triptan therapy, productivity loss was consistently lower for sumatriptan than non-triptan therapy for all predose pain intensity levels.
  
  
  CONCLUSIONS
  These findings suggest that the pharmaco-economic benefits of early intervention with sumatriptan tablets, like the clinical benefits, exceed those of delayed intervention.
authors.affiliation: GlaxoSmithKline, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. jkwong@mail.rx.uga.edu
authors.forename: W Jacqueline
authors.initials: WJ
authors.lastname: Kwong
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Taylor
authors.forename: James U
authors.initials: JU
authors.lastname: Adelman
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy* / Q000503:physiopathology; D010146:Pain / Q000188:drug therapy; D012189:Retrospective Studies; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D018170:Sumatriptan / Q000627:therapeutic use*; D013647:Task Performance and Analysis; D013997:Time Factors
chemical_list: D017366:Serotonin Receptor Agonists; D018170:Sumatriptan