title: Antibody response to Plasmodium vivax antigens in Fy-negative individuals from the Colombian Pacific coast.
abstract: The Duffy antigen (Fy) is necessary for Plasmodium vivax invasion of human erythrocytes. Some populations have a highly prevalent Fy-negative phenotype; such persons are naturally protected from P. vivax blood infection but are expected to completely support the P. vivax pre-erythrocytic cycle, representing a valuable model for studying the immune response during these parasitic stages. We typed 214 individuals, mostly Afro-Colombians, from a P. vivax-endemic area for Fy expression and determined the antibody response to P. vivax pre-erythrocytic (sporozoites and CS) and blood-stage antigens (blood forms, P. vivax merozoite surface protein 1, and P. vivax Duffy binding protein [PvDBP]). Antibody titers to P. vivax circumsporozoite protein, P11, and N-terminal peptides and the number of responders were similar in Fy-negative and Fy-positive individuals. The number of responders to sporozoites, blood forms, and PvDBP were different between these groups. Thus, Fy-negative individuals from malaria-endemic areas can be used to study the immune response to the P. vivax liver phase without interference of the erythrocytic cycle.
authors.affiliation: Malaria Vaccine and Drug Development Center, Cali, Colombia. sherrera@inmuno.org
authors.forename: Sócrates
authors.initials: S
authors.lastname: Herrera
authors.forename: Andrés
authors.initials: A
authors.lastname: Gómez
authors.forename: Omaira
authors.initials: O
authors.lastname: Vera
authors.forename: Juana
authors.initials: J
authors.lastname: Vergara
authors.forename: Augusto
authors.initials: A
authors.lastname: Valderrama-Aguirre
authors.forename: Amanda
authors.initials: A
authors.lastname: Maestre
authors.forename: Fabián
authors.initials: F
authors.lastname: Méndez
authors.forename: Ruobing
authors.initials: R
authors.lastname: Wang
authors.forename: Chetan E
authors.initials: CE
authors.lastname: Chitnis
authors.forename: Syed S
authors.initials: SS
authors.lastname: Yazdani
authors.forename: Myriam
authors.initials: M
authors.lastname: Arévalo-Herrera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D003105:Colombia / Q000453:epidemiology; D004375:Duffy Blood-Group System / Q000378:metabolism*; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax / Q000254:growth & development / Q000276:immunology*; D015995:Prevalence; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012424:Rural Population; D034101:Sporozoites / Q000276:immunology
chemical_list: C473745:ACKR1 protein, human; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D004375:Duffy Blood-Group System; D011956:Receptors, Cell Surface