Iron-responsive regulation of biofilm formation in staphylococcus aureus involves fur-dependent and fur-independent mechanisms.
We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.
Johnson
Miranda
M
Department of Genetics, University of Leicester, UK. jam26@le.ac.uk.
Cockayne
Alan
A
Williams
Peter H
PH
Morrissey
Julie A
JA
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development*; D003470:Culture Media; D015964:Gene Expression Regulation, Bacterial; D007501:Iron; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D013211:Staphylococcus aureus / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; D003470:Culture Media; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron