title: In acute organophosphate poisoning, the efficacy of hemoperfusion on clinical status and mortality.
abstract: The aims of this study were to report experience in patients with organophosphate poisoning (OPP) and to discuss the potential role for hemoperfusion (HP) in the management of severe OPP. At the emergency service of a university hospital, 52 patients with acute OPP were included in this retrospective study. The patients were divided into 2 groups (Group 1, severe poisoning, n = 25; and Group 2, mild poisoning, n = 27). All patients with mild OPP survived. Seven patients (28%) of the 25 with severe OPP died. This study supports previous data documenting that HP is unnecessary in the management of mild OPP. Although there was not a control group (severe poisoning without HP treatment) in this study, experience suggests that HP can be useful in severe cases. Reports from centers having experience with severe OPP can help clarify this controversial issue. Randomized controlled (prospective) studies investigating the possible beneficial effects of HP on patient survival in patients with severe OPP with control group are needed.
authors.affiliation: Department of Internal Medicine, Ondokuz Mayis University, School of Medicine, Samsun, Turkey. leventaltintop@hotmail.com
authors.forename: Levent
authors.initials: L
authors.lastname: Altintop
authors.forename: Dursun
authors.initials: D
authors.lastname: Aygun
authors.forename: Havva
authors.initials: H
authors.lastname: Sahin
authors.forename: Zahide
authors.initials: Z
authors.lastname: Doganay
authors.forename: Hakan
authors.initials: H
authors.lastname: Guven
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Bek
authors.forename: Tekin
authors.initials: T
authors.lastname: Akpolat
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000097:blood / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D000110:Acetylcholinesterase