Cardiac memory ... new insights into molecular mechanisms.
'Cardiac memory' describes an electrocardiographic T wave vector change, recorded during normal sinus rhythm that reflects the QRS complex vector during prior periods of ventricular pacing or arrhythmia. In this brief review we consider the mechanisms responsible for cardiac memory, which offer a unique window for relating molecular determinants of repolarization to their expression in the function of ion channels and in the electrophysiology of the heart. Understanding the steps that translate the molecular mechanisms for memory into clinical expression in this relatively straightforward model facilitates our comprehension of the complex pathways that order normal cardiac repolarization and repolarization changes.
Rosen
Michael R
MR
Department of Pharmacology and Pediatrics, Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. mrr1@columbia.edu
Cohen
Ira S
IS
D000200:Action Potentials / Q000502:physiology; D000804:Angiotensin II / Q000032:analysis / Q000502:physiology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D017362:Cyclic AMP Response Element-Binding Protein / Q000032:analysis / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D010496:Pericardium / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D013997:Time Factors; D014672:Vectorcardiography
D017362:Cyclic AMP Response Element-Binding Protein; D007473:Ion Channels; D000804:Angiotensin II