Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors.
We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy-N-(3-chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an IC(50) of 0.44 microM.
Bouissane
L
L
Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, BP 6759, France.
El Kazzouli
S
S
Léonce
S
S
Pfeiffer
B
B
Rakib
E M
EM
Khouili
M
M
Guillaumet
G
G
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D007191:Indazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007938:Leukemia / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000096926:Benzenesulfonamides
D007191:Indazoles; D013449:Sulfonamides; C508616:N-(7-indazolyl)benzenesulfonamide; D000096926:Benzenesulfonamides