Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities.
The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP508 differed from SP22 and other syringopeptins by having three instead of four alpha,beta-unsaturated amino acids and a longer beta-hydroxy acyl chain. Both SP508 and SP22 displayed growth-inhibitory activities against Mycobacterium smegmatis, other gram-positive bacteria, and yeasts but not against gram-negative bacteria. Structure-activity analyses of the SP508 and SP22 homologs indicated chemical structural features that lead to enhanced antimycobacterial activity by these pseudomonad cyclic lipodepsipeptides.
Grgurina
Ingeborg
I
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università La Sapienza di Roma, Italy.
Bensaci
Mekki
M
Pocsfalvi
Gabriella
G
Mannina
Luisa
L
Cruciani
Oscar
O
Fiore
Alberto
A
Fogliano
Vincenzo
V
Sorensen
Kevin N
KN
Takemoto
Jon Y
JY
D000890:Anti-Infective Agents / Q000494:pharmacology*; D047630:Depsipeptides / Q000494:pharmacology*; D008074:Lipoproteins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D044224:Pseudomonas syringae / Q000737:chemistry*
D000890:Anti-Infective Agents; D047630:Depsipeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; C402636:syringopeptin 22; C508549:syringopeptin 508