Impaired Kupffer cells in highly susceptible mice infected with Trypanosoma congolense.
In highly susceptible BALB/c mice infected with Trypanosoma congolense, the total number of Kupffer cells in the liver remains constant; however, their mean size increases fivefold towards the terminal stage. About 25% of Kupffer cells undergo apoptosis. We suggest that development of an impairment of the macrophage system might be a major mechanism for inefficient elimination of trypanosomes.
Shi
Meiqing
M
Department of Veterinary Microbiology, WCVM, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, S7N 5B4, Canada.
Wei
Guojian
G
Pan
Wanling
W
Tabel
Henry
H
D000818:Animals; D017209:Apoptosis; D002452:Cell Count; D004198:Disease Susceptibility / Q000276:immunology / Q000469:parasitology; D007728:Kupffer Cells / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000276:immunology* / Q000469:parasitology