Cytotoxic clerodane diterpenes from Glossocarya calcicola.
Three clerodane diterpenes were isolated and identified from leaf extract of Glossocarya calcicola. Compound has been characterised as (rel)-10betaH-trans-12xi-(2-methylbut-2(E)-enoyl)-1beta-(isobutanoyl)-6alpha,13xi-dihydroxyclerodan-4(20),8(18)-dien-7,15-dione-15,16-oxide, to which we have assigned the trivial name calcicolin-A. The other two compounds had the same skeletal structure and C-12 substituent but in compound, the C-1 esterifying group becomes 2-methylbut-2(E)-enoic acid and in it becomes 2-methylbutanoic acid. Although anti-insect activity was not observed for G. calcicola, cytotoxicity against insect and human carcinoma cell lines was detected.
Rasikari
Heidi L
HL
Centre for Phytochemistry and Pharmacology, Southern Cross University, Military Rd., Level 2, Lismore, N.S.W. 2780, Australia. hrasik10@scu.edu.au
Leach
David N
DN
Waterman
Peter G
PG
Spooner-Hart
Robert N
RN
Basta
Albert H
AH
Banbury
Linda K
LK
Winter
Kelly M
KM
Forster
Paul I
PI
D000818:Animals; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007306:Insecticides / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D008322:Mammals; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D045785:Diterpenes, Clerodane; D007306:Insecticides; D010936:Plant Extracts; C507929:calcicolin-A