title: Computational simulation of a non-newtonian model of the blood separation process.
abstract: The aim of this work is to construct a computational fluid dynamics model capable of simulating the transient non-Newtonian process of apheresis. A Lagrangian-Eulerian model has been developed which tracks the blood particles within a two-dimensional flow configuration. Within the Eulerian method, the fluid mass and momentum conservation equations within the separator are solved using the density and the viscosity is calculated from the blood particle concentrations. Subsequently, the displacement of the blood particles is calculated with a Lagrangian method. Hawksley's model for the density of supensions is used in the variable density calculation. The viscosity is calculated with two models based on Vand's rigid particle suspension viscosity concepts, followed by the flow field calculation in the separator. Simulations were performed for various inlet hematocrit values and separator lengths. The simulations are in satisfactory agreement with experimental results reported in literature, indicating a complete separation of plasma and red blood cells (RBCs), as well as nearly complete separation of red blood cells and platelets. No hemolysis was observed in the simulations because the shear rate remained under the critical value of 150 N/m2.
authors.affiliation: Laboratory of Thermodynamics in Emerging Technologies, Swiss Federal Institute of Technology (ETH), ETH Zentrum, Zurich, Switzerland.
authors.forename: Sandro
authors.initials: S
authors.lastname: De Gruttola
authors.forename: Kevin
authors.initials: K
authors.lastname: Boomsma
authors.forename: Dimos
authors.initials: D
authors.lastname: Poulikakos
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D001781:Blood Component Removal; D002469:Cell Separation / Q000379:methods*; D002498:Centrifugation; D003198:Computer Simulation; D004912:Erythrocytes; D018056:Hemorheology; D006801:Humans; D008954:Models, Biological