IgH/TCR rearrangements are common in MLL translocated adult AML and suggest an early T/myeloid or B/myeloid maturation arrest, which correlates with the MLL partner.
Dupret
C
C
Asnafi
V
V
Leboeuf
D
D
Millien
C
C
Ben Abdelali
R
R
Preudhomme
C
C
Beldjord
K
K
Delabesse
E
E
Macintyre
E
E
D000208:Acute Disease; D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D019070:Cell Lineage; D015321:Gene Rearrangement; D019672:Genes, T-Cell Receptor; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D022423:Myeloid Cells / Q000473:pathology; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D013601:T-Lymphocytes / Q000473:pathology; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains; D051788:Myeloid-Lymphoid Leukemia Protein