Pharmacological correction of changes in the lung-placenta system under experimental conditions.
Pathological changes in the fetoplacental complex and lung-placenta system were observed in rats with experimental gestosis produced by long-term feeding of a high-sodium diet. We revealed a decrease in the weights of the placenta and fetus, pulmonary fibrinolytic dysfunction, and increased production of cortisol. The course of fraxiparine treatment in animals with experimental gestosis decreased coagulation activity of the arterial blood, increased the weights of the placenta and fetus, and reduced the concentration of stress hormone cortisol.
Myasnikova
V V
VV
Krasnodar Branch, Southern Department of the Russian Academy of Medical Sciences. vivlad7@rambler.ru
Galenko-Yaroshevskii
P A
PA
Lysenkov
S P
SP
Kupreishvili
V Z
VZ
Rizhvadze
M R
MR
Sukoyan
G V
GV
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000196:embryology* / Q000378:metabolism; D017762:Nadroparin / Q000494:pharmacology; D010920:Placenta / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000473:pathology; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D012492:Salts / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D017762:Nadroparin; D012492:Salts; D005340:Fibrinogen; D012964:Sodium; D006854:Hydrocortisone