title: Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count.
abstract: The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Schacker
authors.forename: Cavan
authors.initials: C
authors.lastname: Reilly
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Beilman
authors.forename: Jodie
authors.initials: J
authors.lastname: Taylor
authors.forename: David
authors.initials: D
authors.lastname: Skarda
authors.forename: David
authors.initials: D
authors.lastname: Krason
authors.forename: Matthew
authors.initials: M
authors.lastname: Larson
authors.forename: Ashley T
authors.initials: AT
authors.lastname: Haase
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005355:Fibrosis; D015658:HIV Infections / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*