[Genetic mutations of heamagglutinin genes of H9N2 subtype influenza A viruses in the field in a five-year period].
Infection in chicken flocks on a farm, where AI outbreak took place in 1998, was monitored in a four-year consecutive period and 22 H9N2 subtype viruses were isolated. The HA gene and antigenicity of 9 strains among isolates were compared with that of isolate of 1998. The results indicated that mutations of HA genes of H9 subtype influenza A viruses were observed during five years. However these mutations of HA genes didn't lead to sufficient antigenic variation to change the cross-protective pattern of these strains. These findings may be fruitful for making further study of genetic mutations of AIVs in the field and improving the control strategies.
Liu
Hongqi
H
Key Laboratory of Animal Infectious Diseases of Ministry of Agriculture, Yangzhou University, Yangzhou 225009, China. liuhqdhl@sina.com.cn
Zhang
Pinghu
P
Liu
Xiufan
X
Liu
Wenbo
W
Jia
Lijun
L
D000818:Animals; D002645:Chickens; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks / Q000662:veterinary; D006384:Hemagglutination; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics* / Q000276:immunology; D053127:Influenza A Virus, H9N2 Subtype / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D005585:Influenza in Birds / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D009154:Mutation; D010802:Phylogeny; D011201:Poultry Diseases / Q000276:immunology / Q000821:virology*
D019267:Hemagglutinin Glycoproteins, Influenza Virus