Novel endoperoxides: synthesis and activity against Candida species.
Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.
Macreadie
Peter
P
CSIRO, Molecular and Health Technologies, Parkville, 3052 Victoria, Australia.
Avery
Thomas
T
Greatrex
Ben
B
Taylor
Dennis
D
Macreadie
Ian
I
D002175:Candida / Q000145:classification* / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D013237:Stereoisomerism
D010545:Peroxides