title: Continuation of hormone replacement therapy in Slovenia: a prospective, randomized, controlled trial--1-year follow-up.
abstract: OBJECTIVE
  To evaluate the influence of educational intervention on the hormone replacement therapy (HRT) continuation rate in Slovenia after the publication of WHI results.
  
  
  METHODS
  We enrolled 125 early postmenopausal women in a 12-month prospective, randomized, controlled, multicentric study in Slovenia. The study group women (n=62) attended educational lectures; the control group women (n=63) did not. Data were collected from three types of questionnaire: before starting HRT, at follow-up visits at 3, 6, 9 and 12 month, after the educational lecture (study group). The continuation rate was measured on the basis of women's self-reports. The results were analyzed according to the "intention-to-treat" principle. The Cox proportional hazard model was used for the final analysis.
  
  
  RESULTS
  A gynecologist's suggestion, climacteric symptoms and quality of life were the prevailing reasons for starting HRT. The prevailing factors affecting continuation of HRT were: no or irregular previous OC use (hazard ratio 3.7), no educational lectures (hazard ratio 2.0) and climacteric disorders as the reason for start HRT (hazard ratio 2.1). In the women who discontinued HRT within the first 3 months, the fear of endometrial cancer, breast cancer and bleeding problems were statistically more significant than other factors (P=0.034). In the women who stopped HRT use within 6-12 months, the fear of breast and endometrial cancers increased substantially (P=0.002).
  
  
  CONCLUSIONS
  Previous OC use and educational lectures on menopausal problems and HRT significantly improve the HRT continuation rate. The main reason for discontinuing HRT is fear of breast cancer, intensified by media.
authors.affiliation: Outpatient Clinic of Obstetrics and Gynecology, Celjska 10, 3250 Rogaska Slatina, and Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia. damir.franic@guest.arnes.si
authors.forename: Damir
authors.initials: D
authors.lastname: Franić
authors.forename: Ivan
authors.initials: I
authors.lastname: Verdenik
authors.forename: Helena
authors.initials: H
authors.lastname: Meden-Vrtovec
authors.forename: Igor
authors.initials: I
authors.lastname: Svab
mesh_terms: D000328:Adult; D015914:Estrogen Replacement Therapy / Q000379:methods* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance; D010353:Patient Education as Topic; D011446:Prospective Studies; D017524:Slovenia