Neonatal lung remodeling: structural, inflammatory, and ventilator-induced injury.
The developing lung is subject to events, both prenatal and postnatal, that alter the normal developmental process. The degree of insult or injury affects how the lung functions at birth and then responds to the insult throughout childhood. In this article, only 3 of the influences are examined: structural, inflammatory, and mechanical. It is recognized that there is a plethora of other factors that influence lung remodeling.
Turner
Barbara S
BS
School of Nursing, Duke University, Durham, NC 27710, USA. turne017@mc.duke.edu
Bradshaw
Wanda
W
Brandon
Debra
D
D001997:Bronchopulmonary Dysplasia / Q000209:etiology / Q000503:physiopathology; D006548:Hernia, Diaphragmatic / Q000503:physiopathology; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000503:physiopathology; D008168:Lung / Q000002:abnormalities / Q000196:embryology / Q000254:growth & development*; D008171:Lung Diseases / Q000209:etiology / Q000503:physiopathology*; D012121:Respiration, Artificial / Q000009:adverse effects; D015619:Respiratory System Abnormalities / Q000503:physiopathology