title: Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.
abstract: The CH(2)Cl(2)-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 microg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 microg/ml.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
authors.forename: Eduardo M N
authors.initials: EM
authors.lastname: Nakashima
authors.forename: Surya K
authors.initials: SK
authors.lastname: Kalauni
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kurashima
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Esumi
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D010936:Plant Extracts; C508941:angelmarin