[Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress].
The flavonoid alpha-glucosylrutin (AGR) is a potent antioxidant with a high epidermal bioavailability. This makes this substance particularly suitable for various dermato-cosmetic applications. Flavonoids are phytamines with a common chemical structure and a broad range of activities, the most prominent being their radical scavenging ability. Reactive oxygen species (ROS) damage cells by different mechanisms. Direct cytotoxic effects include destruction of the cell membrane by causing radical chain reactions or induction of mutagenic changes in the nuclear and mitochondrial DNA. Indirect changes involve modification of intracellular signal transduction pathways that regulate inflammatory or proliferative activities. The excellent antioxidant efficacy of AGR has been shown in various experimental studies, both in vitro and in vivo. Subsequent clinical studies have demonstrated that AGR is also effective in the prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption (PLE). Other promising dermato-cosmetic areas for AGR application are aging of the skin, especially photoaging. All in vivo evaluations indicate that AGR in the applied concentrations is a very well-tolerated ingredient for medical skin care preparations.
Wolber
Rainer
R
Beiersdorf AG, Hamburg.
Stäb
Franz
F
Max
Heiner
H
Wehmeyer
Annegret
A
Hadshiew
Ina
I
Wenck
Horst
H
Rippke
Frank
F
Wittern
Klaus-Peter
KP
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D005419:Flavonoids / Q000008:administration & dosage*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012431:Rutin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism*; D016896:Treatment Outcome; D014312:Trisaccharides
D000975:Antioxidants; D005419:Flavonoids; D017382:Reactive Oxygen Species; D014312:Trisaccharides; C069037:4(G)-alpha-glucopyranosyl-rutin; D012431:Rutin