SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.
The 2,4-disubstituted thiadiazolidinones (TDZD) are described as the first ATP-noncompetitive GSK-3 inhibitors. Following an SAR study about TDZD, different structural modifications in the heterocyclic ring aimed to test the influence of each heteroatom on the biological study are here reported here. Various compounds such as hydantoins, dithiazolidindiones, rhodanines, maleimides, and triazoles were synthesized and screened as GSK-3 inhibitors. After an extensive SAR study among these different heterocyclic families, TDZDs have been revealed as a privileged scaffold for the selective inhibition of GSK-3. A CoMFA analysis was also performed highlighting the molecular electrostatic field interaction in the interaction of TDZDs with GSK-3. Moreover, first mapping studies indicate two binding modes which in turn might imply relevant differences in the mechanism that underly the inhibitory activity of TDZDs.
Martinez
Ana
A
Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. amartinez@neuropharma.es
Alonso
Mercedes
M
Castro
Ana
A
Dorronsoro
Isabel
I
Gelpí
J Luis
JL
Luque
F Javier
FJ
Pérez
Concepción
C
Moreno
Francisco J
FJ
D001665:Binding Sites; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D006827:Hydantoins / Q000138:chemical synthesis / Q000737:chemistry; D008301:Maleimides / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D011485:Protein Binding; D021281:Quantitative Structure-Activity Relationship; D012236:Rhodanine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D006827:Hydantoins; D008301:Maleimides; D013830:Thiadiazoles; D012236:Rhodanine; D038362:Glycogen Synthase Kinase 3