title: Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.
abstract: The transcription factor nuclear factor-kappaB (NF-kappaB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-kappaB transcriptional activity but are devoid of conventional estrogenic activity.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville PA 19426, USA. sabatuj@wyeth.com
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Sabatucci
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ashwell
authors.forename: Eugene
authors.initials: E
authors.lastname: Trybulski
authors.forename: Mary-Margaret
authors.initials: MM
authors.lastname: O'Donnell
authors.forename: William J
authors.initials: WJ
authors.lastname: Moore
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Harnish
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Chadwick
mesh_terms: D000818:Animals; D002460:Cell Line; D008024:Ligands; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011960:Receptors, Estrogen / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D008024:Ligands; D016328:NF-kappa B; D011960:Receptors, Estrogen; D013449:Sulfonamides