Structure-activity relationships of dengue antiviral polycyclic quinones.
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.
Laurent
Dominique
D
Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR152 IRD - Université Paul Sabatier, Centre IRD, Nouméa, Nouvelle-Calédonie, France.
Baumann
Francine
F
Benoit
Anne Gaelle
AG
Mortelecqe
Alain
A
Nitatpattana
Narong
N
Desvignes
Isabelle
I
Debitus
Cécile
C
Laille
Manola
M
Gonzalez
Jean-Paul
JP
Chungue
Eliane
E
D000818:Animals; D003716:Dengue Virus; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons; D011809:Quinones; D013329:Structure-Activity Relationship
D011084:Polycyclic Aromatic Hydrocarbons; D011809:Quinones; C437338:gymnochrome A