Systemic lupus erythematosus (SLE) presenting with nephrotic syndrome and membranous glomerulopathy in a 10-year-old girl.
The authors report the case of a 10-y-old girl with clinical diagnosis of systemic lupus erythematosus (SLE), made at the age of 6 y, based upon arthritis, serositis, haematological disorder and positive antinuclear antibody. The first manifestation of disease--Raynaud's phenomenon--appeared at the age of 4 y. Seven months after the diagnosis, she developed nephrotic proteinuria with haematuria. Percutaneous renal biopsy showed membranous glomerulonephritis, the least common form of lupus nephritis.


CONCLUSIONS
Intravenous cyclophosphamide therapy associated with oral prednisolone proved effective in inducing complete remission of nephrotic syndrome.
Machado
Vânia
V
Department of Paediatrics, Hospital de São João, Porto, Portugal. vaniamachado@mail.telepac.pt
Pontes
Teresa
T
Brito
Iva
I
Afonso
Caldas
C
D000974:Antibodies, Antinuclear / Q000032:analysis; D001707:Biopsy, Needle; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D007677:Kidney Function Tests; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000188:drug therapy; D009404:Nephrotic Syndrome / Q000175:diagnosis* / Q000628:therapy; D011239:Prednisolone / Q000008:administration & dosage; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000974:Antibodies, Antinuclear; D003520:Cyclophosphamide; D011239:Prednisolone