Lack of association between VEGF polymorphisms and ALS in a Dutch population.
Sequence alterations in the promoter region of the vascular endothelial growth factor (VEGF) gene have been implicated in increasing the risk of developing ALS. VEGF promoter haplotypes were determined in 373 patients with sporadic ALS and 615 matched healthy controls in The Netherlands. No significant association between the previously reported at-risk haplotypes and ALS was found. Pooling our results with the previously studied population still showed a significant association with the AAG haplotype.
Van Vught
P W J
PW
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands. p.w.j.vanvught@neuro.azu.nl
Sutedja
N A
NA
Veldink
J H
JH
Koeleman
B P C
BP
Groeneveld
G J
GJ
Wijmenga
C
C
Uitdehaag
B M J
BM
de Jong
J M B V
JM
Baas
F
F
Wokke
J H J
JH
Van den Berg
L H
LH
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D001483:Base Sequence / Q000235:genetics; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009426:Netherlands; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012737:Sex Factors; D042461:Vascular Endothelial Growth Factor A / Q000172:deficiency / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A