title: The natural history of lower urinary tract dysfunction in men: minimum 10-year urodynamic follow-up of untreated bladder outlet obstruction.
abstract: OBJECTIVE
  To assess the long-term outcomes of untreated bladder outlet obstruction (BOO), assuming that, if there is little or no deterioration, a conservative approach to management is justified, as there is little information on the natural history of untreated BOO and lower urinary tract symptoms (LUTS) in men, and studies to date suggest that neither BOO nor LUTS inevitably progress to a stage at which prostatectomy is required.
  
  
  METHODS
  Men aged >45 years who were investigated in our department between 1972 and 1986, diagnosed with BOO, and who initially opted for no specific treatment were invited for repeat symptomatic and urodynamic evaluation. Identical methods of assessment were used, allowing results to be compared directly.
  
  
  RESULTS
  In all, 1068 men were initially diagnosed with BOO; 428 (40%) of these died. Of the 170 men who initially opted for a conservative approach and attended for repeat assessment, 141 (83%) remained untreated, with a mean follow-up of 13.9 years. The only significant urodynamic changes were a reduction in detrusor contractility and an increased prevalence of detrusor overactivity. Most patients reported no change in their symptoms but a significant minority experienced a gradual deterioration. Of the 29 men in whom the conservative approach failed, 22 proceeded to surgery for LUTS, and seven for acute urinary retention.
  
  
  CONCLUSIONS
  Patients with untreated BOO do not significantly deteriorate urodynamically in the long term, with only a minority deteriorating symptomatically. These findings justify a conservative approach to men with LUTS associated with BOO.
authors.affiliation: Bristol Urological Institute, Bristol, UK. alun.thomas@which.net
authors.forename: Alun W
authors.initials: AW
authors.lastname: Thomas
authors.forename: Andrea
authors.initials: A
authors.lastname: Cannon
authors.forename: Esther
authors.initials: E
authors.lastname: Bartlett
authors.forename: Julie
authors.initials: J
authors.lastname: Ellis-Jones
authors.forename: Paul
authors.initials: P
authors.lastname: Abrams
mesh_terms: D000368:Aged; D000465:Algorithms; D016009:Chi-Square Distribution; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018709:Statistics, Nonparametric; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D016055:Urinary Retention / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D014563:Urodynamics / Q000502:physiology*