title: Multiple roles of cyclooxygenase-2 in endometrial cancer.
abstract: Cyclooxygenase-2 (COX-2) plays a critical role not only in maintenance of the endometrium during the menstrual cycle, but also in the progression of endometrial cancer. The role of COX-2 in tumor growth and development is complex and multifaceted. This review presents evidence for the expression of COX-2 being linked to angiogenesis, tumor cell apoptosis, tumor cell growth, metastasis and local immunosuppression in cancer progression. It also outlines the clinicopathological and prognostic significance of COX-2 in endometrial cancer.
authors.affiliation: Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan. satoshio@cit.med.osaka-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ohno
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inagawa
authors.forename: Chie
authors.initials: C
authors.lastname: Kohchi
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Soma
authors.forename: Masaki
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans
chemical_list: D051546:Cyclooxygenase 2