Increased granulocyte chemotactic protein-2 concentrations in peritoneal fluid of women with endometriosis.
BACKGROUND
To evaluate the release of granulocyte chemotactic protein-2 (GCP-2) into peritoneal fluid in women with endometriosis, we measured its concentration with reference to the disease stage and the phase of the menstrual cycle.


METHODS
Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 64 women with endometriosis (n = 38) or cystadenomas (n = 26). GCP-2 concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay.


RESULTS
Our findings indicated elevated concentrations of GCP-2 in peritoneal fluid from women with endometriosis during the proliferative phase, which were positively correlated with the stage of endometriosis.


CONCLUSIONS
Inflammation associated with endometriosis may be involved in the pathogenesis of the disease through increasing levels of peritoneal fluid GCP-2.
Suzumori
Nobuhiro
N
Department of Obstetrics & Gynecology, Nagoya City University Graduate School of Medicine, 1-Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan. og.n.suz@med.nagoya-cu.ac.jp
Zhao
Xaio Xi
XX
Suzumori
Kaoru
K
D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism; D016022:Case-Control Studies; D054427:Chemokine CXCL6; D019743:Chemokines, CXC / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006098:Granulocytes; D006801:Humans; D008597:Menstrual Cycle; D008875:Middle Aged; D012720:Severity of Illness Index
C515503:CXCL6 protein, human; D054427:Chemokine CXCL6; D019743:Chemokines, CXC