title: Perospirone in the treatment of schizophrenia: effect on verbal memory organization.
abstract: The present study was performed to determine if perospirone, a novel antipsychotic drug with D2/5-HT2A antagonist and partial 5-HT1A agonist properties, would improve memory organization in twelve patients with chronic schizophrenia. Switching to equivalent dose of perospirone from prior antipsychotic medication was associated with a significant improvement in indices of verbal memory organization of the Auditory Verbal Learning Test. Negative symptoms and extrapyramidal side effects were also ameliorated after switching to perospirone. The distinct cognitive enhancement profile of perospirone may be attributable to its partial 5-HT1A agonist action.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Araki
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yamasue
authors.forename: Tomiki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Motomu
authors.initials: M
authors.lastname: Suga
authors.forename: Akira
authors.initials: A
authors.lastname: Iwanami
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D054833:Isoindoles; D008297:Male; D008568:Memory / Q000187:drug effects*; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D018709:Statistics, Nonparametric; D013844:Thiazoles / Q000627:therapeutic use*; D014706:Verbal Learning / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D007211:Indoles; D054833:Isoindoles; D013844:Thiazoles; C065533:perospirone