title: Relation between plasma adenosine and serum TSH levels in women with hyperemesis gravidarum.
abstract: BACKGROUND
  This study investigated the relation between adenosine and thyroid function associated with hyperemesis gravidarum.
  
  
  METHODS
  We examined 84 Japanese singleton pregnant women with an average age of 33.0+/-5.8 years at 9-12 weeks gestation being managed at our hospital. The patients were divided into three groups according to the severity of emesis: (1) those with hyperemesis gravidarum (nausea and vomiting with weight loss >5%, n=13), (2) those with emesis (nausea and vomiting with weight loss <5%, n=31), and (3) those with no symptoms as a control (n=40).
  
  
  RESULTS
  The average serum TSH levels in the emesis and hyperemesis groups were significantly higher than that in the control group (P<0.05). The average plasma adenosine level in the hyperemesis group was significantly higher than those in the control pregnant and emesis groups (P<0.05). There were no significant differences in plasma adenosine levels between the control pregnant and emesis groups. The serum TSH level showed significant correlations with weight loss (%) and plasma adenosine levels (P<0.05).
  
  
  CONCLUSIONS
  Our findings support the possible role of adenosine in counteracting the further progression of hyperemesis gravidarum associated with gestational thyrotoxicosis.
authors.affiliation: Department of Obstetrics and Gynecology, Tokyo Rinkai Hospital, 1-4-2 Rinkai-cho, Edogawa-ku, 134-0086 Tokyo, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Murata
authors.forename: Shunji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takeshita
mesh_terms: D000241:Adenosine / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D007564:Japan; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012720:Severity of Illness Index; D013971:Thyrotoxicosis / Q000097:blood / Q000150:complications; D013972:Thyrotropin / Q000097:blood*; D015431:Weight Loss / Q000502:physiology
chemical_list: D013972:Thyrotropin; D000241:Adenosine