Nimesulide-induced fixed drug eruption.
BACKGROUND
Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. It is a widely used and well tolerated nonsteroidal antiinflammatory drug that also has analgesic and antipyretic properties. The most frequently reported side effects concern the gastrointestinal tract. Pruritus and skin rash are the most common cutaneous adverse reactions. There are only eight cases of fixed drug eruptions due to nimesulide, described in the literature.


METHODS
The authors report a case of a patient with a history of antihistamine hypersensitivity who developed a bullous form of pigmented fixed drug eruption after nimesulide ingestion. Patch tests performed on residual skin lesion were positive to nimesulide, confirming that this was the culprit drug.


CONCLUSIONS
Fixed drug eruptions are common cutaneous drug reactions, often misdiagnosed. A detailed anamnesis and physical examination are the key to suspect this condition.
Malheiro
D
D
Allergy and Clinical Immunology Department. Hospital São João. Porto. Portugal. danielamalheiro@hotmail.com
Cadinha
S
S
Rodrigues
J
J
Vaz
M
M
Castel-Branco
M G
MG
D000082:Acetaminophen / Q000008:administration & dosage; D000328:Adult; D001977:Brompheniramine / Q000008:administration & dosage / Q000009:adverse effects; D002110:Caffeine / Q000008:administration & dosage; D017291:Clarithromycin / Q000009:adverse effects; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D010879:Piperazines / Q000009:adverse effects; D016037:Single-Blind Method; D012882:Skin Tests; D013262:Stevens-Johnson Syndrome / Q000209:etiology; D013449:Sulfonamides / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced
D004338:Drug Combinations; D006634:Histamine H1 Antagonists; D010879:Piperazines; D013449:Sulfonamides; D000082:Acetaminophen; D002110:Caffeine; D017291:Clarithromycin; D001977:Brompheniramine; C015408:oxatomide; C012655:nimesulide