title: Stress and pain responses in rats lacking CCK1 receptors.
abstract: CCK involvement in stress- and pain-responsiveness was examined by studying the behavior of infant (11-12-days-old) and adult OLETF rats that do not express CCK1 receptors. Infant odor- and texture-preferences were also assessed. We hypothesized that OLETF rats will show behavioral patterns similar to those previously observed after CCK1 antagonist administration. Rate of separation-induced ultrasonic vocalization was significantly greater in OLETF compared to controls, in two separate studies. Infant pups of the two strains did not differ in odor- and texture-preference tests. OLETF rats showed consistently longer hot-plate paw-lift (as infants, in two separate studies) and paw-lick (as adults) latencies.
  
  
  CONCLUSIONS
  OLETF pups vocalized in isolation more than controls and showed relative hypoalgesic responses, evident also in adulthood, in concordance with the pharmacological literature.
authors.affiliation: Interdisciplinary Program in the Brain Sciences, Bar Ilan University, Ramat-Gan, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Hurwitz
authors.forename: O
authors.initials: O
authors.lastname: Malkesman
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: M
authors.initials: M
authors.lastname: Schroeder
authors.forename: Y
authors.initials: Y
authors.lastname: Lavi-Avnon
authors.forename: M
authors.initials: M
authors.lastname: Shayit
authors.forename: Y
authors.initials: Y
authors.lastname: Shavit
authors.forename: G
authors.initials: G
authors.lastname: Wolf
authors.forename: R
authors.initials: R
authors.lastname: Yirmiya
authors.forename: A
authors.initials: A
authors.lastname: Weller
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D005260:Female; D008297:Male; D009812:Odorants; D010146:Pain / Q000473:pathology*; D010147:Pain Measurement; D017288:Pain Threshold; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000235:genetics* / Q000502:physiology*; D013312:Stress, Physiological / Q000473:pathology*; D013997:Time Factors
chemical_list: D011949:Receptors, Cholecystokinin