title: Should kidneys from older cadaveric donors be age-matched to the recipient?
abstract: Persistent shortage of kidneys for transplantation has forced most transplant centers to include procurement and use of kidneys from older donors. It is not clear whether the optimal use of these kidneys involve age-matching to the recipient. The aim of this study was to evaluate the clinical outcome of older cadaveric kidneys (>60 years), transplanted to young recipients (<50 years) and older recipients (>60 years). From 1989 through 2002, 252 first kidney grafts were procured from donors above the age of 60; 149 of the recipients to these grafts were above 60 years and 45 recipients were below 50. Minimum follow-up time was 12 months. Variables for waiting time to transplantation, DR mismatches, PRA, dialysis prior to transplantation, episodes of acute rejection, number of steroid-resistant rejections, creatinine levels, cold ischemia time, and causes of graft loss did not differ between the two groups. There was no significant difference in graft survival for young and older recipients receiving kidney from donors above 60 years of age. Graft survival at 1 year for young recipients was 90% and for older recipients 93% (NS). Five-year graft survival was 72% and 79%, respectively (NS). However, there was a significant positive effect on long-term graft survival if the donor kidney was less than 50 years. From our data, there is no evidence that age-matching of older donors has any beneficial effect on graft survival in kidney transplantation.
authors.affiliation: Department of Surgery, Section of Transplant Surgery, Rikshospitalet, N-0027 Oslo, Norway. aksel.foss@rikshospitalet.no
authors.forename: A
authors.initials: A
authors.lastname: Foss
authors.forename: D
authors.initials: D
authors.lastname: Tuvin
authors.forename: T
authors.initials: T
authors.lastname: Leivestad
authors.forename: O
authors.initials: O
authors.lastname: Øyen
authors.forename: Ø
authors.initials: Ø
authors.lastname: Bentdal
mesh_terms: D000328:Adult; D000368:Aged; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data*