Type 2 diabetes mellitus in youth: the complete picture to date.
Type 2 diabetes mellitus is a heterogeneous condition in which the clinical manifestation of hyperglycemia is a reflection of the impaired balance between insulin sensitivity and insulin secretion. Clinical experience and research in youth type 2 diabetes mellitus are in an early stage because of the relative novelty of the condition in pediatrics. This article discusses the amassed information in type 2 diabetes mellitus of youth to date with respect to the epidemiology, pathophysiology, risk factors, clinical presentation, screening, and management strategies.
Gungor
Neslihan
N
Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA.
Hannon
Tamara
T
Libman
Ingrid
I
Bacha
Fida
F
Arslanian
Silva
S
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002648:Child; D048909:Diabetes Complications / Q000378:metabolism / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D004032:Diet; D050171:Dyslipidemias / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy / Q000209:etiology; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000473:pathology; D008019:Life Style; D008687:Metformin / Q000627:therapeutic use; D012307:Risk Factors
D001323:Autoantibodies; D007004:Hypoglycemic Agents; D008687:Metformin