Synthesis of 5-aminolevulinic acid (ALA) and its t-butyl ester for the fluorescence detection of early cancer.
5-Aminolevulinic acid and its derivatives, which are known to affect the early diagnosis and treatment of cancer, have been synthesized. Simple methods for the synthesis of 5-aminolevulinic acid (ALA), a precursor of porphyrins, have been developed in our laboratory for use in studies on the biosynthesis of porphyrins.
Kang
Min-Seok
MS
College of Pharmacy, Kyung Hee University, Seoul, Korea.
Kim
Dong-Myung
DM
Kim
Jeong Sook
JS
Jeong
Jin-Hyun
JH
D000622:Aminolevulinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D042241:Early Diagnosis; D005453:Fluorescence; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
C505153:5-aminolevulinic acid n-butyl ester; D000622:Aminolevulinic Acid