title: Hypersensitivity to mosquito bites as a potential sign of mantle cell lymphoma.
abstract: Hypersensitivity to mosquito bites (HMB) is known to be an allergic reaction and also a skin symptom in some cases of natural killer cell leukemia/lymphoma associated with Epstein-Barr virus (EBV) infection. We describe a patient who had suffered from HMB for 5 years, and subsequently developed mantle cell lymphoma (MCL), which resembled chronic lymphocytic leukemia in the early phase. EBV monoclonality was not detected in lymph nodes by Southern blotting. Serum levels of interleukin-4 and IgE were increased, but they decreased and HMB disappeared when MCL was predominant. We consider that HMB may be a potential sign of MCL.
authors.affiliation: Division of Hematology and Rheumatology, Department of Medicine, The Tazuke Kofukai Medical Research Institute, Osaka.
authors.forename: Akane
authors.initials: A
authors.lastname: Kunitomi
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Konaka
authors.forename: Masato
authors.initials: M
authors.lastname: Yagita
mesh_terms: D000818:Animals; D009033:Culicidae; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007299:Insect Bites and Stings / Q000150:complications*; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged