[Electrochemotherapy and its mechanism for sarcoma of KM mice].
In this paper are analyzed the effect of electrochemotherapy and its mechanism. The favorable parameter of electric pulses (EP) was studied in vitro using the S-180 cells exposed to various EP. After the tumor model was copied, the tumor-bearing mice were randomly divided into four groups: control, chemotherapy, electrotherapy, and electrochemotherapy. The tumor inhibitory ratio, the cure ratio and the level of oxygen free radicals (OFR) were determined. The inhibitory ratio and cure ratio of electrochemotherapy group were significantly higher than those in the chemotherapy, electrotherapy and control groups (P < 0.05). The injury of OFR was decreased while the immunological competence was increased. The mechanism of electrochemotherapy may be related with the enhancement of cell membranepermeability, the depression of drug resistance, the improvement of immunological competence, and so on.
Yang
Kong
K
College of Life Sciences, Sichuan University, Chengdu 610064, China.
He
Miao
M
Wang
Zishu
Z
Zou
Fangdong
F
Yue
Bisong
B
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods*; D004563:Electrochemistry; D018274:Electroporation / Q000379:methods*; D051379:Mice; D011897:Random Allocation; D012510:Sarcoma 180 / Q000628:therapy*
D000970:Antineoplastic Agents; D001761:Bleomycin