title: Validation of a brief screening instrument for substance abuse and mental illness in HIV-positive patients.
abstract: BACKGROUND
  Substance abuse (SA) and mental illness (MI) commonly co-occur with HIV infection in the United States and have important implications for clinical management of HIV/AIDS. Yet SA/MI often go untreated due in part to a lack of practical, validated screening tools.
  
  
  METHODS
  HIV clinic in academic medical center.
  
  
  METHODS
  The 16-item SA/MI Symptoms Screener (SAMISS) targets SA/MI in HIV-positive patients. Consecutive consenting HIV-positive patients completed the SAMISS and then a reference standard diagnostic tool, SCID, the Structured Clinical Interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition).
  
  
  RESULTS
  Twenty percent of participants (29/148) had an SA diagnosis and 41% (59/143) had an MI diagnosis in the past year on the SCID; 48% (68/143) had 1 or both. Thirty-seven percent (55/148) screened positive for SA and 69% (99/143) screened positive for MI on the SAMISS. The SAMISS had 86% (95% CI: 68%-96%) sensitivity and 75% (66%-82%) specificity for SA and 95% (86%-99%) sensitivity and 49% (38%-60%) specificity for MI. Patients with SA were likely to show up as false positives for MI and vice versa.
  
  
  CONCLUSIONS
  The SAMISS functioned well as a first-line screening tool for SA/MI in this HIV clinic population. It missed few cases and was easily incorporated into a busy clinical setting. Persons screening positive require a more rigorous confirmatory psychiatric evaluation.
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160, USA.
authors.forename: Brian Wells
authors.initials: BW
authors.lastname: Pence
authors.forename: Bradley N
authors.initials: BN
authors.lastname: Gaynes
authors.forename: Kathryn
authors.initials: K
authors.lastname: Whetten
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Eron
authors.forename: Robert W
authors.initials: RW
authors.lastname: Ryder
authors.forename: William C
authors.initials: WC
authors.lastname: Miller
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000150:complications / Q000175:diagnosis*; D011795:Surveys and Questionnaires