Pathogenesis and natural history of usual interstitial pneumonia: the whole story or the last chapter of a long novel.
Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) is not well-understood. Current explanations of the natural history and pathogenesis of IPF/UIP are controversial, and ongoing research continues to investigate multiple hypotheses. A complete understanding of the natural history of IPF could potentially help to identify different mechanisms that are operative at the early, intermediate, and end stages of the disease. This knowledge could lead to the development of more effective therapeutic interventions that target stage-specific aberrant pathways involved in IPF/UIP pathogenesis.
Strieter
Robert M
RM
David Geffen School of Medicine, University of California at Los Angeles, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90095-1786, USA. rstrieter@mednet.ucla.edu
D019743:Chemokines, CXC / Q000502:physiology; D018450:Disease Progression; D004847:Epithelial Cells / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D020411:Oligonucleotide Array Sequence Analysis; D011658:Pulmonary Fibrosis / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods
D019743:Chemokines, CXC; D016222:Fibroblast Growth Factor 2