title: Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists.
abstract: Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V2 receptor selective agonists exemplified by the 5,11-dihydro-pyrido[2,3-b][1,5]benzodiazepine as a candidate for further development.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. faillia@wyeth.com
authors.forename: Amedeo A
authors.initials: AA
authors.lastname: Failli
authors.forename: Jay S
authors.initials: JS
authors.lastname: Shumsky
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Steffan
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Caggiano
authors.forename: David K
authors.initials: DK
authors.lastname: Williams
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Trybulski
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Ning
authors.forename: Yeungwai
authors.initials: Y
authors.lastname: Lock
authors.forename: Tarak
authors.initials: T
authors.lastname: Tanikella
authors.forename: David
authors.initials: D
authors.lastname: Hartmann
authors.forename: Peter S
authors.initials: PS
authors.lastname: Chan
authors.forename: C H
authors.initials: CH
authors.lastname: Park
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001552:Benzazepines / Q000008:administration & dosage; D001569:Benzodiazepines / Q000008:administration & dosage / Q000145:classification* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D008970:Molecular Weight; D051381:Rats; D017207:Rats, Sprague-Dawley; D017483:Receptors, Vasopressin / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: C509747:5,11-dihydro-pyrido(2,3-b)(1,5)benzodiazepine; D001552:Benzazepines; D017483:Receptors, Vasopressin; C509746:WAY-151932; D001569:Benzodiazepines