title: Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene.
abstract: Past research investigating the role of the serotonin transporter gene in OCD has produced mixed findings. One possible reason for the mixed findings is comorbidity. In this study, non-comorbid OCD individuals were compared to non-disordered controls. A sample of panic disordered individuals was also compared to a non-disordered group. Finally, as an exploratory analysis, individuals were assessed for OCPD and their allelic frequencies were also compared to non-disordered individuals. Analyses revealed that there were higher frequencies of the s/s genotype among the OCD group when compared to non-disordered controls. There were no differences in allelic frequencies on the serotonin transporter gene between the panic disordered group, the OCPD group, and the non-disordered control group. This study found that non-comorbid OCD individuals tended to have a higher percentage of the homozygous short genotype than non-disordered individuals. The s/s genotype might serve as a contributory risk factor for OCD.
authors.affiliation: Texas A&M University, Department of Psychology, College Station, TX 77843, USA. perez@psyc.tamu.edu
authors.forename: Marisol
authors.initials: M
authors.lastname: Perez
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Brown
authors.forename: Suzanne
authors.initials: S
authors.lastname: Vrshek-Schallhorn
authors.forename: Frank
authors.initials: F
authors.lastname: Johnson
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Joiner
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003193:Compulsive Personality Disorder / Q000175:diagnosis* / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000235:genetics; D016584:Panic Disorder / Q000175:diagnosis* / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D050486:Serotonin Plasma Membrane Transport Proteins