[Tendency and mathematical model of relationship of blood ATP content with temperature and time of preservation].
To investigate the relationship of blood ATP content with temperature and time of preservation and to establish its mathematical model, adenosine triphosphate (ATP) concentration was applied as the index of the quality of erythrocytes; systematical study on variation of blood preserved in a series of different temperatures from 4 degrees C to 32 degrees C was performed, and a series of experimental data were obtained. The results showed that when the ATP concentration y = f (d, t, s) in preserved blood was given as the continuous function of the time (d), the temperature (t) and the initiate ATP concentration (s), the model was fitted with the theory of linearity regression in symbolic statistics, and the general mathematical physical equation of the variation of preserved blood quality was deduced. According to the equation, the whole blood in CPDA-1 solution could be efficiently stored for 35, 35, 29, 22, 18, 18, 13, 8, 7, 6, 6, 5, 4, 4 and 3 days in 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30 and 32 degrees C, respectively. In conclusion, the general tendency of the variation of preserved blood quality according to the temperature and the time was systematically disclosed for the first time, which would be propitious to estimate the blood quality in various temperatures and to instruct clinical blood transfusion.
Ren
Su-Ping
SP
Beijing Institute of Transfusion Medicine, Beijing 100850, China.
Li
Cheng-Yue
CY
Liu
An
A
Zheng
Jian-Hong
JH
Zhong
Shi-Zeng
SZ
Han
Ying
Y
D000255:Adenosine Triphosphate / Q000097:blood*; D001793:Blood Preservation; D006801:Humans; D008962:Models, Theoretical; D013696:Temperature; D013997:Time Factors
D000255:Adenosine Triphosphate