title: Cancer risk in asthmatic populations.
abstract: OBJECTIVE
  To conduct a meta-analysis of epidemiologic studies to derive a pooled estimate of the association between asthma and cancer incidence and between allergy and cancer incidence.
  
  
  METHODS
  Five cohort studies and 1 case-control study of cancer incidence in asthma, 4 studies of cancer mortality in asthma, and 3 studies of cancer incidence in allergy.
  
  
  METHODS
  We searched the National Library of Medicine Gateway to identify observational studies of cancer incidence in asthma and included any case-control or cohort study of incident cancers or of cancer mortality that met the predefined inclusion criteria.
  
  
  RESULTS
  There was no significant association between asthma and cancer incidence. A single large cohort study demonstrated a protective effect of asthma; the remaining cohort studies demonstrated a slightly elevated risk of cancer associated with asthma. Inconsistencies in study design features included control of smoking in analyses, use of a control group, and methods to identify asthma status.
  
  
  CONCLUSIONS
  The method of asthma identification affects the validity of asthma classification and the severity of asthma examined. The inconsistency in study designs could have contributed to the variability in results and the underestimation of the impact of asthma on cancer incidence.
authors.affiliation: RTI Health Solutions, Research Triangle Park, North Carolina 27709-2194, USA. ptennis@rti.org
authors.forename: Patricia
authors.initials: P
authors.lastname: Tennis
authors.forename: Beth
authors.initials: B
authors.lastname: Sherrill
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernandez
authors.forename: Chantal
authors.initials: C
authors.lastname: Dolan
mesh_terms: D001249:Asthma / Q000150:complications*; D016022:Case-Control Studies; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology