title: Changes in the epidemiology of epiglottitis following introduction of Haemophilus influenzae type b (Hib) conjugate vaccines in England: a comparison of two data sources.
abstract: Paediatric cases of epiglottitis declined markedly in England following the introduction of safe effective immunization against Haemophilus influenzae type b (Hib). With the recently described resurgence in Hib infections, a corresponding rise in the number of presentations of clinical epiglottitis in children was observed, although numbers were still well below those reported prior to vaccine availability. This was seen both in microbiology reports and hospital admissions data for England. In keeping with the more diverse aetiology of epiglottitis in adults, Hib vaccination had minimal impact on hospital presentations with upper airway infections in those aged 15 years and over, which showed an overall increasing trend over 10 years. The need for a high index of suspicion to allow early diagnosis of this life-threatening clinical presentation is reinforced.
authors.affiliation: Immunisation Department, Health Protection Agency Centre for Infections, Colindale, London, UK. mcvernon@unimelb.edu.au
authors.forename: J
authors.initials: J
authors.lastname: McVernon
authors.forename: M P E
authors.initials: MP
authors.lastname: Slack
authors.forename: M E
authors.initials: ME
authors.lastname: Ramsay
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016667:Bacterial Capsules; D004739:England / Q000453:epidemiology; D004826:Epiglottitis / Q000453:epidemiology*; D006192:Haemophilus Infections / Q000453:epidemiology*; D018073:Haemophilus Vaccines / Q000276:immunology*; D019741:Haemophilus influenzae type b; D006801:Humans; D008875:Middle Aged; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination
chemical_list: D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial