title: Preparation of a highly stable niosome and its hydrotrope-solubilization action to drugs.
abstract: Highly stable niosomes are prepared and investigated in Tween80/PEG6000/Span80/H2O system. The mean radius of the niosomes is 0.15-0.2 microm. The contents of PEG6000 and Span80 and the system temperature affect the size and the stability of the niosome. A certain Span80 can remarkably improve the stability. The niosome is provided distinctly with the hydrotrope-solubilization action to the hydrophilic drug and hydrophobic drug, which affects the niosome membrane. The mechanism of the effects of PEG6000 and Span80 on the niosome is discussed in this paper.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Jinagsu 210093, PR China. tqliu@yzu.edu.cn
authors.forename: Tianqing
authors.initials: T
authors.lastname: Liu
authors.forename: Rong
authors.initials: R
authors.lastname: Guo
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D006601:Hexoses; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011092:Polyethylene Glycols; D011136:Polysorbates; D012995:Solubility; D013696:Temperature
chemical_list: D004337:Drug Carriers; D006601:Hexoses; D008081:Liposomes; D004364:Pharmaceutical Preparations; D011136:Polysorbates; C018665:sorbitan monooleate; D011092:Polyethylene Glycols