Long-lasting improvement of myocardial perfusion and chronic refractory angina after autologous intramyocardial PBSC transplantation.
We report the case of a 60-year-old man with patent coronary by-pass grafts on the left anterior descending and circumflex coronary arteries, who experienced recurrent Canadian class IV angina refractory to medical and interventional treatments for a dominant right coronary artery occlusion. He underwent autologous PBSC transplant into the inferior ventricular wall through a minimally invasive approach as a stand-alone therapy, in an attempt to induce therapeutic angiogenesis. Six months after the operation, angina significantly ameliorated; scintigraphy and coronary angiography showed a marked improvement in perfusion of the target injection area. These benefits had persisted at 25 months after stem cell transplant.
Pompilio
G
G
Research Unit for Cardiovascular Tissue Repair, Centro Cardiologico Monzino IRCCS, Milano, Italy.
Cannata
A
A
Pesce
M
M
Capogrossi
M C
MC
Biglioli
P
P
D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000628:therapy*; D017023:Coronary Angiography; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D015425:Myocardial Reperfusion; D036102:Peripheral Blood Stem Cell Transplantation; D015899:Tomography, Emission-Computed, Single-Photon