title: No evidence for association between dyslexia and DYX1C1 functional variants in a group of children and adolescents from Southern Italy.
abstract: Recently, DYX1C1, a candidate gene for developmental dyslexia, encoding a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain, has been characterized through a translocation breakpoint in a Finnish family. Two putatively functional variants, -3G/A and 1249G/T, have been reported to be significantly associated with dyslexia in this population. Further studies, conducted on different ethnic groups (English and Canadian), have not confirmed a role for DYX1C1 variants in increasing the risk for dyslexia. We investigated the role of these variants in dyslexic children and adolescents from Southern Italy. No significant evidence for association between dyslexia and these DYX1C1 putative functional variants has been shown. We argue that the different DYX1C1 allele frequencies shown among Italian and Finnish subjects with dyslexia could be attributable to the different linkage disequilibrium structure of these populations.
authors.affiliation: Chair of Child Neuropsychiatry, Department of Pediatrics, Second University of Naples, Naples, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bellini
authors.forename: Carmela
authors.initials: C
authors.lastname: Bravaccio
authors.forename: Filippo
authors.initials: F
authors.lastname: Calamoneri
authors.forename: Maria
authors.initials: M
authors.lastname: Donatella Cocuzza
authors.forename: Pasquale
authors.initials: P
authors.lastname: Fiorillo
authors.forename: Antonella
authors.initials: A
authors.lastname: Gagliano
authors.forename: Domenico
authors.initials: D
authors.lastname: Mazzone
authors.forename: Emanuele Miraglia
authors.initials: EM
authors.lastname: del Giudice
authors.forename: Geoffredo
authors.initials: G
authors.lastname: Scuccimarra
authors.forename: Roberto
authors.initials: R
authors.lastname: Militerni
authors.forename: Antonio
authors.initials: A
authors.lastname: Pascotto
mesh_terms: D000293:Adolescent; D002648:Child; D003598:Cytoskeletal Proteins; D004410:Dyslexia / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005387:Finland; D005787:Gene Frequency; D006801:Humans; D007558:Italy; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
chemical_list: D003598:Cytoskeletal Proteins; C478878:DNAAF4 protein, human; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins