title: Changes in first-pass interstitial kinetics of DTPA in myocardium submitted to low-flow ischemia.
abstract: OBJECTIVE
  This study aimed to determine the changes during ischemia in the myocardial first-pass kinetics of DTPA, an extracellular tracer that is currently used for assessing myocardial perfusion with magnetic resonance imaging (Magnevist).
  
  
  METHODS
  Using an indicator-dilution technique, first-pass kinetics of DTPA were compared between normoxia (n=11) and low-flow ischemia (n=11) in isolated rabbit hearts perfused with red blood cell-enhanced perfusate.
  
  
  RESULTS
  There was no difference between ischemia and normoxia in the interstitial extraction and clearance rates of DTPA. Interstitial distribution volume of DTPA was, however, lower in ischemia than in normoxia (in percent of myocardial volume: 15+/-11% vs 25+/-11%, P=0.02) as a result of a relationship with coronary flow (P<0.001).
  
  
  CONCLUSIONS
  During low-flow myocardial ischemia, DTPA kinetics are unchanged, except for the interstitial distribution volume that is decreased, presumably because of the shrinkage of extracellular fluid. These kinetic properties are favorable for detecting myocardial ischemia at rest with magnetic resonance imaging.
authors.affiliation: Department of Nuclear Medicine, Unité mixte UHP-Inserm U684, and the Laboratory of Hematology and Physiology, Faculty of Pharmacy, University Henri Poincaré, Nancy, France. Fatiha.Maskali@medecine.uhp-nancy.fr
authors.forename: Fatiha
authors.initials: F
authors.lastname: Maskali
authors.forename: Adey
authors.initials: A
authors.lastname: Ayalew
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Marie
authors.forename: Patrick
authors.initials: P
authors.lastname: Menu
authors.forename: Laurent
authors.initials: L
authors.lastname: Antunes
authors.forename: Paul-Michel
authors.initials: PM
authors.lastname: Mertes
authors.forename: Faïez
authors.initials: F
authors.lastname: Zannad
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Gravier
authors.forename: Gilles
authors.initials: G
authors.lastname: Karcher
authors.forename: Alain
authors.initials: A
authors.lastname: Bertrand
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003287:Contrast Media; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA