title: Acute changes in circulating hormones in older patients with impaired ventricular function undergoing on-pump coronary artery bypass grafting.
abstract: OBJECTIVE
  Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) causes an acute stress response characterized by changes in the levels of several hormones, which might play a role in the high complication rate experienced by older patients after CABG. Thus, the aim of the study was to investigate changes in the circulating levels of anabolic and catabolic hormones in old people undergoing CABG with CPB.
  
  
  METHODS
  Intervention case study.
  
  
  METHODS
  19 patients (12 males, 7 females) aged 70.1 +/- 6.1 yr (age range 62-80) with coronary artery disease and an ejection fraction <40% who underwent cardiac surgery. Cortisol (Cort), DHEA, DHEAS, LH, estradiol (E2), total testosterone (Te), SHBG, IGF-I were measured the day before, on the day of the procedure and 1, 2, 3, 4, and 30 days after CABG.
  
  
  RESULTS
  After surgery, serum IGF-I levels decreased (p<0.001), while levels of Cort, DHEAS and E2 significantly increased in both men and women. Alterations in Te levels differed between the two sexes with a significant decline in men and a significant increment in women.
  
  
  CONCLUSIONS
  CABG with CPB resulted in a dramatic drop in Te levels in old men and a significant decline in IGF-I in both sexes. Serum Cort levels also significantly increased in both sexes. These hormonal changes may, at least partially, explain why the elderly need prolonged rehabilitation after CABG.
authors.affiliation: Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), USA.
authors.forename: M
authors.initials: M
authors.lastname: Maggio
authors.forename: G P
authors.initials: GP
authors.lastname: Ceda
authors.forename: G
authors.initials: G
authors.lastname: De Cicco
authors.forename: E
authors.initials: E
authors.lastname: Cattadori
authors.forename: S
authors.initials: S
authors.lastname: Visioli
authors.forename: F
authors.initials: F
authors.lastname: Ablondi
authors.forename: C
authors.initials: C
authors.lastname: Beghi
authors.forename: T
authors.initials: T
authors.lastname: Gherli
authors.forename: S
authors.initials: S
authors.lastname: Basaria
authors.forename: G
authors.initials: G
authors.lastname: Ceresini
authors.forename: G
authors.initials: G
authors.lastname: Valenti
authors.forename: L
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000097:blood / Q000601:surgery*; D003687:Dehydroepiandrosterone / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D006728:Hormones; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D006854:Hydrocortisone