title: The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the St. Jude Children's Research Hospital Experience.
abstract: BACKGROUND
  It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients.
  
  
  METHODS
  The authors reviewed the records of 124 patients > 1 year of age at diagnosis of International Neuroblastoma Staging System Stage 4 neuroblastoma. The survival estimates of those who did and did not have a gross total resection (GTR) and of those who had initial versus delayed GTR were compared. Surgical complications were reviewed.
  
  
  RESULTS
  The 5-year survival estimates were comparable for the 90 patients who had a GTR and the 17 who underwent surgery but did not have a GTR (29.9% +/- 5.1% [standard error] vs. 29.4% +/- 10.1%). The 7 patients who underwent GTR at the time of diagnosis had a higher 5-year survival estimate than the 83 patients who had a GTR after induction chemotherapy (83.3% +/- 13.9% vs. 25.2% +/- 5.0%) (P = 0.001). Five-year event-free survival estimates were similarly higher in the initial-GTR group (57.1% +/- 18.7% vs. 14.5% +/- 4.2%) (P = 0.002). These two groups did not differ significantly in age at diagnosis (P = 0.118), site of primary tumor (P = 0.34), MYCN amplification status (P = 1), serum lactate dehydrogenase activity at diagnosis (P = 0.34), or treatment protocol (P = 0.22). Twenty-two (21%) patients had a surgical complication.
  
  
  CONCLUSIONS
  In this small cohort of patients with metastatic neuroblastoma, GTR at the time of diagnosis offered a survival benefit. Further prospective studies are warranted before this approach can be applied to all patients with metastatic neuroblastoma.
authors.affiliation: Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. lisa.mcgregor@stjude.org
authors.forename: Lisa M
authors.initials: LM
authors.lastname: McGregor
authors.forename: Bhaskar N
authors.initials: BN
authors.lastname: Rao
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davidoff
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Billups
authors.forename: Suradej
authors.initials: S
authors.lastname: Hongeng
authors.forename: Victor M
authors.initials: VM
authors.lastname: Santana
authors.forename: D Ashley
authors.initials: DA
authors.lastname: Hill
authors.forename: Christine
authors.initials: C
authors.lastname: Fuller
authors.forename: Wayne L
authors.initials: WL
authors.lastname: Furman
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D042241:Early Diagnosis; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D019635:Neurosurgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000401:mortality; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome