title: CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.
abstract: There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF beta-amyloid(1-42) (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF Abeta42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.
authors.affiliation: Department of Neurology, St. Vincent's Hospital, University of New South Wales, Sydney, Australia. b.brew@unsw.edu.au
authors.forename: B J
authors.initials: BJ
authors.lastname: Brew
authors.forename: L
authors.initials: L
authors.lastname: Pemberton
authors.forename: K
authors.initials: K
authors.lastname: Blennow
authors.forename: A
authors.initials: A
authors.lastname: Wallin
authors.forename: L
authors.initials: L
authors.lastname: Hagberg
mesh_terms: D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000821:virology; D000328:Adult; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism / Q000503:physiopathology / Q000821:virology; D005260:Female; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000134:cerebrospinal fluid; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D012016:Reference Values; D019562:Viral Load; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; D012367:RNA, Viral; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D019798:Neopterin