title: [An unusual case of pyoderma gangrenosum with necrotizing granulomatous dermatitis].
abstract: Four distinctive clinical and histological variants of pyoderma gangrenosum have been proposed: (1) ulcerative, (2) pustular, (3) bullous, and (4) vegetative. The rate of progression and associated systemic diseases, as well as the histopathologic changes, can vary considerably between these clinical variants. A 64-year-old man presented with ulcerative pyoderma gangrenosum associated with renal cell carcinoma and IgA paraproteinemia; he responded to oral thalidomide. Histopathology revealed unusual findings with signs of leukocytoclastic vasculitis, basophilic degeneration of collagen and zones of suppuration with a palisaded histiocytic and epithelioid granulomatous infiltration throughout the dermis.
authors.affiliation: Abteilung für Dermatologie, Universität Tübingen, Tübingen, Deutschland. friedegund.meier@med.uni-tuebingen.de
authors.forename: Friedegund
authors.initials: F
authors.lastname: Meier
authors.forename: Diana
authors.initials: D
authors.lastname: Berner
authors.forename: Christian
authors.initials: C
authors.lastname: Scherwitz
authors.forename: Gernot
authors.initials: G
authors.lastname: Rassner
authors.forename: Gisela
authors.initials: G
authors.lastname: Metzler
mesh_terms: D003872:Dermatitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D006099:Granuloma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D035583:Rare Diseases / Q000175:diagnosis / Q000188:drug therapy; D013792:Thalidomide / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013792:Thalidomide