Outcome of in vitro fertilization treatment in patients who electively inseminate a limited number of oocytes to avoid creating surplus human embryos for cryopreservation.
OBJECTIVE
To determine whether the outcome of IVF treatment in patients who electively inseminate a limited number of oocytes is comparable to that in a group of good-prognostic or poor-prognostic patients.


METHODS
Retrospective clinical study.


METHODS
University-based tertiary fertility center.


METHODS
Two hundred three women under the age of 40 years.


METHODS
Patients undergoing their first cycle of IVF who elected to have no more than four oocytes inseminated (study group) or who produced only four or fewer oocytes (poor-prognostic group) or who had excess embryos cryopreserved (good-prognostic group).


METHODS
Implantation rate, clinical pregnancy rate, and ongoing pregnancy rate.


RESULTS
There were no significant differences in the implantation rate for the study group when compared with the good-prognostic group or the poor-prognostic group. The clinical pregnancy rate (62.5% vs. 64%) and ongoing-pregnancy or birth rate (56.3% vs. 60.7%) were similar between the study group and the good-prognostic group. However, the clinical pregnancy rate (62.5% vs. 29.7%) and ongoing-pregnancy rate (56.3% vs. 24.3%) were higher in the study group compared with the poor-prognostic group.


CONCLUSIONS
Inseminating fewer oocytes in patients who elect not to cryopreserve excess embryos does not adversely affect their probability of conception.
Engmann
Lawrence
L
The Center for Advanced Reproductive Services, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030-6224, USA.
Siano
Linda
L
Schmidt
David
D
Benadiva
Claudio
C
Maier
Donald
D
Nulsen
John
J
D000328:Adult; D016009:Chi-Square Distribution; D015925:Cryopreservation / Q000379:methods / Q000706:statistics & numerical data*; D004622:Embryo, Mammalian; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D009865:Oocytes; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies