title: Cytotoxic sesquiterpene lactones from Saussurea calcicola.
abstract: Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8alpha-hydroxy-11alpha, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3beta-hydroxy-8alpha-epoxymethylacriloiloxy-4(15),10(14),11(13)-trien-guaian-6,12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23-1.72 microg/mL.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes