title: The effect of colloidal fluid replacement on wound healing in an experimental sublethal hemorrhagic shock model.
abstract: OBJECTIVE
  The aim of the study was to evaluate the effects of different resuscitation solutions on wound healing in an animal model of sublethal hemorrhagic shock.
  
  
  METHODS
  Sublethal hemorrhagic shock was established by blood withdrawal until the mean arterial pressure fell to 40 mmHg within 15 min. Animals were resuscitated with four different solutions: group I (n=19) 0.9% NaCl, group II (n=20) 10% dextran 40, group III (n=20) 6% hydroxyethyl starch, group IV (n=18) 4% modified fluid gelatin. Following inhalation anesthesia, a full thickness skin incision of 2 cm in length was made on the abdominal wall and sutured primarily. The incision wound on the abdominal wall was excised on the fifth day. The breaking strength of the incision and hydroxyproline content of dry tissue were evaluated.
  
  
  RESULTS
  Differences in breaking strength values were observed between groups I-III and I-IV (P<0.05). Hydroxyproline values were significantly lower in group IV (58.47 microg/ml) and group II (69.17 microg/ml) (P<0.05). The gelatin-resuscitated group had lower breaking strength and hydroxyproline values than the other groups.
  
  
  CONCLUSIONS
  It can be concluded that resuscitation with modified fluid gelatin may have detrimental effects on wound healing in an experimental model of sublethal hemorrhagic shock.
authors.affiliation: Department of General Surgery, Suleyman Demirel University, School of Medicine, Isparta, Turkey. heroleroglu@hotmail.com
authors.forename: Erol
authors.initials: E
authors.lastname: Eroglu
authors.forename: Fusun
authors.initials: F
authors.lastname: Eroglu
authors.forename: Lutfi
authors.initials: L
authors.lastname: Yavuz
authors.forename: Canan
authors.initials: C
authors.lastname: Agalar
authors.forename: Fatih
authors.initials: F
authors.lastname: Agalar
mesh_terms: D000818:Animals; D003102:Colloids / Q000627:therapeutic use*; D005440:Fluid Therapy / Q000379:methods*; D006909:Hydroxyproline / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003102:Colloids; D006909:Hydroxyproline