title: GM-CSF action in the CNS decreases food intake and body weight.
abstract: Many proinflammatory cytokines, such as leptin, play key roles in dynamic regulation of energy expenditure and food intake. The present work tested a role for the proinflammatory cytokine GM-CSF. Central but not peripheral administration of GM-CSF to adult rats significantly decreased food intake and body weight for at least 48 hours. Similar results were observed following central administration of GM-CSF in mice. GM-CSF receptor immunoreactivity was found on neurons within the paraventricular and arcuate nuclei of the hypothalamus. GM-CSF-deficient (GM-/-) mice weighed more and had significantly higher total body fat than wild-type (GM+/+) mice. Energy expenditure in GM-/- mice was decreased compared with that in GM+/+ mice. Taken together, these findings demonstrate that GM-CSF signaling in the CNS can regulate energy homeostasis.
authors.affiliation: University of Cincinnati, Cincinnati, Ohio, USA.
authors.forename: Jacquelyn A
authors.initials: JA
authors.lastname: Reed
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Clegg
authors.forename: Kathleen Blake
authors.initials: KB
authors.lastname: Smith
authors.forename: Emeline G
authors.initials: EG
authors.lastname: Tolod-Richer
authors.forename: Emily K
authors.initials: EK
authors.lastname: Matter
authors.forename: Lara S
authors.initials: LS
authors.lastname: Picard
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Seeley
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000502:physiology; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D020318:Rats, Long-Evans; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000235:genetics; D011994:Recombinant Proteins / Q000235:genetics; D015431:Weight Loss / Q000502:physiology*
chemical_list: D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor