[Pemphigoid gestationis--first sign of metastatic choriocarcinoma].
A 29-year-old woman developed pruritic urticarial plaques and vesicles 3 months after delivery of a healthy daughter. Two months later pemphigoid gestationis (PG) was diagnosed based on histopathological and immunopathological findings. At the same time elevated serum levels for beta-HCG and a large mass in the liver were noted. A liver biopsy confirmed the diagnosis of metastatic choriocarcinoma, which was responsible for the PG metastasis. Upon initiation of chemotherapy, complete healing of the PG was observed within 4 weeks and autoantibodies to BP180NC16A could no longer be identified. In parallel, both a decrease of beta-HCG levels and tumor size was observed.
Sinemus
Kathrin
K
Hautklinik Wuppertal, Klinik für Dermatologie, Allergologie und Umweltmedizin, Klinikum der Universität Witten-Herdecke, Helios Klinikum Wuppertal GmbH. Dr.KathrinSinemus@web.de
Zillikens
Detlef
D
Lehmann
Percy
P
D000328:Adult; D002822:Choriocarcinoma / Q000473:pathology* / Q000556:secondary*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D006559:Pemphigoid Gestationis / Q000473:pathology*; D011247:Pregnancy