[Changes of the thyroid hormone status in children with cerebral palsy and other neurological pathology].
Content of thyroid hormones (T3 and T4) and thyrotropin (TTG) hormone in blood plasma has been studied in 142 children with neurological pathology (cerebral palsy, perinatal CNS lesion). In most cases, there was a significant increase of T3 and T4 and reduction of TTG as compared to control group of healthy children. The changes of thyroid hormones content depended on the patient's age and severity of a pathological condition. A mother pregnancy course impacted on the hormones level. The content of T3 and T4 in blood plasma was higher in case of cystitis in mother's anamnesis or a persistent threat of preterm delivery. In patients, a TTG reduction correlated with mental retardation. In those with marked dysplasia of osseous tissue (osteoclast, osteopathy), the TTG content was higher comparing to patients without such malformations.
Vasil'eva
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Shor
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Poddubnaia
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D000367:Age Factors; D001720:Birth Injuries / Q000097:blood*; D001930:Brain Injuries / Q000097:blood*; D002547:Cerebral Palsy / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003556:Cystitis; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine