title: Surveillance of imported bancroftian filariasis after two-year multiple-dose diethylcarbamazine treatment.
abstract: Myanmar migrants are at increased risk for nocturnally periodic Wuchereria bancrofti causing imported bancroftian filariasis. They have a significant influence on the effectiveness of diethylcarbamazine (DEC) mass treatment at the provincial level in the National Program to Eliminate Lymphatic Filariasis (PELF) during the fiscal years (FY) 2002-2006, in Thailand. Two oral doses of DEC 6 mg/kg are given twice a year to the eligible Myanmar migrants (> or = 2 years old). A 300 mg DEC provocation test is given once a year to all Myanmar migrants with work permits. Effectiveness evaluation parameters, such as cumulative index (CI) and the effectiveness ratio (ER), were obtained after 2 years of the multiple-dose DEC treatment program in Ranong Province, Southern Thailand. By cross-sectional night blood surveys at the end of FY 2003 in two districts of Ranong Province, the microfilarial positive rates (MPR) were 0.8% and 1.2% for Mueang Ranong and Kra Buri, respectively. The MPR in the agricultural (1.5%) and industrial (0.4%) occupations were not significantly different from each other. Our findings suggest that most untreated microfilaremics working in agriculture, with short-term residency in Thailand, may have delayed multiple-dose DEC treatment.
authors.affiliation: Office of Disease Prevention and Control 11, Nakhon Si Thammarat, Department of Disease Control, Ministry of Public Health, Nakhon Si Thammarat, Thailand.
authors.forename: Surachart
authors.initials: S
authors.lastname: Koyadun
authors.forename: Adisak
authors.initials: A
authors.lastname: Bhumiratana
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003430:Cross-Sectional Studies; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005368:Filariasis / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D005369:Filaricides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D002052:Myanmar / Q000208:ethnology; D015995:Prevalence; D018571:Sentinel Surveillance; D013785:Thailand / Q000453:epidemiology; D014171:Transients and Migrants; D014958:Wuchereria bancrofti
chemical_list: D005369:Filaricides; D004049:Diethylcarbamazine