title: Elevated plasma concentrations of haptoglobin in European brown bears during hibernation.
abstract: Haptoglobin (Hp), a hemoglobin-binding protein, is known as an acute phase protein and increases during the acute phase of inflammation in most mammals. We reported previously in brown bears that the mean Hp concentrations were higher in blood samples obtained in winter than those in spring. To examine a possible relation of the seasonal variations of Hp to hibernation, in the present study, we measured the plasma concentrations of Hp as well as some other acute phase proteins (alpha(2)-macroglobulin, alpha(1)-antitrypsin, C-reactive protein) in 6 European brown bears (Ursus arctos), from which blood samples were obtained at 5-6 different months of year including February, the time of hibernation. The Hp concentrations showed clear seasonal variations, being highest in February. The alpha(2)-macroglobulin concentrations also showed a similar but much smaller rise in February, but those of alpha(1)-antitrypsin and C-reactive protein did not show any seasonal variations. Our results suggest that the seasonal variation of plasma Hp concentration in brown bears is associated with a hibernation-specific mechanism more than that of acute phase response.
authors.affiliation: Laboratory of Biochemistry, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. momi@m.ehime-u.ac.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Mominoki
authors.forename: Masami
authors.initials: M
authors.lastname: Morimatsu
authors.forename: Minna
authors.initials: M
authors.lastname: Karjalainen
authors.forename: Esa
authors.initials: E
authors.lastname: Hohtola
authors.forename: Raimo
authors.initials: R
authors.lastname: Hissa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saito
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D005260:Female; D006242:Haptoglobins / Q000032:analysis / Q000378:metabolism*; D006605:Hibernation / Q000502:physiology*; D008297:Male; D012621:Seasons; D001503:Ursidae / Q000097:blood / Q000502:physiology*; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000032:analysis / Q000378:metabolism
chemical_list: D006242:Haptoglobins; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D002097:C-Reactive Protein