The gonadotrophins response to GnRH test is not a predictor of neurological lesion in girls with central precocious puberty.
OBJECTIVE
To assess the value of gonadotrophin releasing hormone (GnRH) stimulation test in identifying intracranial abnormality in girls with central precocious puberty (CPP).


METHODS
A study of 67 girls diagnosed with CPP who underwent cranial MRI scans. Patients were not receiving any therapy and there were no neurological signs or symptoms at presentation. Patients underwent evaluation of GnRH stimulation test and plasma oestradiol levels at presentation.


RESULTS
Mean age at onset of puberty was 6.2 years (range 2.0 to 8.0 years). Intracranial abnormalities were present in 10 (15%) patients, while 57 girls (85%) had no abnormalities. No significant difference was shown between girls with intracranial abnormality and girls without intracranial abnormality in basal LH or FSH values, peak LH or FSH values, LH/FSH peak ratios, peak LH/basal LH ratios, peak FSH/ basal FSH ratios at presentation.


CONCLUSIONS
GnRH stimulation test does not identify those with underlying intracranial abnormality at presentation. MRI imaging remains necessary in all cases of central precocious puberty in girls.
Ng
Sze May
SM
Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool, UK. ngszemay@yahoo.com
Kumar
Yadlapalli
Y
Cody
Declan
D
Smith
Colin
C
Didi
Mohammed
M
D001932:Brain Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D011237:Predictive Value of Tests; D011629:Puberty, Precocious / Q000097:blood / Q000209:etiology*
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone