title: A highly efficient solid-phase synthesis of 1,3-substituted xanthines.
abstract: A first solid-phase route to 1,3-substituted xanthines has been developed using PS-MB-CHO resin. Cyclocondensation of the polymer-bound aminoimidazole with isocyanates followed by alkylation provided 1,3-substituted xanthines in high yields. Libraries of 12 xanthines and 4 thioxanthines were prepared.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore.
authors.forename: Rongjun
authors.initials: R
authors.lastname: He
authors.forename: Yulin
authors.initials: Y
authors.lastname: Lam