title: Copy number of DAZ genes in infertile men.
abstract: The aim of the study was to define the relevance of deletions and duplications within the DAZ gene cluster to male factor infertility in a population of 90 infertile men and a control of 50 fertile men using real-time polymerase chain reaction (PCR). We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure.
authors.affiliation: Division of Medical Genetics, University Medical Center, Ljubljana, Slovenia.
authors.forename: Karin
authors.initials: K
authors.lastname: Writzl
authors.forename: Branko
authors.initials: B
authors.lastname: Zorn
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
mesh_terms: D041322:Chromosomes, Human, Y / Q000235:genetics; D000075364:Deleted in Azoospermia 1 Protein; D017353:Gene Deletion; D018628:Gene Dosage / Q000235:genetics*; D020440:Gene Duplication; D005858:Germany; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D005810:Multigene Family / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D016601:RNA-Binding Proteins