Efficacy of caspofungin against Aspergillus terreus.
We investigated the in vitro and in vivo activities of caspofungin against Aspergillus terreus. The drug increased survival and reduced tissue fungal burden in neutropenic mice. Therefore, our data support the role of caspofungin in treating systemic infections due to this emerging pathogen.
Barchiesi
Francesco
F
Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I-Lancisi-Salesi, Via Conca, Torrette, Ancona 60020, Italy. l.infettive@ao-umbertoprimo.marche.it
Spreghini
Elisabetta
E
Santinelli
Alfredo
A
Fothergill
Annette W
AW
Fallani
Stefania
S
Manso
Esther
E
Pisa
Eleonora
E
Giannini
Daniele
D
Novelli
Andrea
A
Cassetta
Maria I
MI
Mazzei
Teresita
T
Rinaldi
Michael G
MG
Scalise
Giorgio
G
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001230:Aspergillus / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D000077336:Caspofungin; D004195:Disease Models, Animal; D054714:Echinocandins; D055666:Lipopeptides; D051379:Mice; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology* / Q000627:therapeutic use*
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin