title: Synthesis, structure and anti-acetylcholinesterase activity of 4beta-methoxymethyl-4beta-demethyl territrem B.
abstract: 4beta-Methoxymethyl-4beta-demethyl territrem B [5] was synthesized from 4beta-hydroxymethyl-beta-demethyl territrem B [4] by treatment with dimethyl sulfate in methanolic NaOH. The structure of 5 was elucidated by uv, nmr and mass spectra. The IC50 of 5 on acetylcholinesterase (AChE) was 6.30 x 10(-5) M, which indicated 0.4% of the anti-AChE activity of territrem B [2].
authors.affiliation: Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
authors.forename: F C
authors.initials: FC
authors.lastname: Peng
authors.forename: J S
authors.initials: JS
authors.lastname: Cheng