Protein variety and functional diversity: Swiss-Prot annotation in its biological context.
We all know that the dogma 'one gene, one protein' is obsolete. A functional protein and, likewise, a protein's ultimate function depend not only on the underlying genetic information but also on the ongoing conditions of the cellular system. Frequently the transcript, like the polypeptide, is processed in multiple ways, but only one or a few out of a multitude of possible variants are produced at a time. An overview on processes that can lead to sequence variety and structural diversity in eukaryotes is given. The UniProtKB/Swiss-Prot protein knowledgebase provides a wealth of information regarding protein variety, function and associated disorders. Examples for such annotation are shown and further ones are available at http://www.expasy.org/sprot/tutorial/examples_CRB.
Boeckmann
Brigitte
B
Swiss Institute of Bioinformatics, Centre Médical Universitaire, 1, rue Michel-Servet, 1211 Genève 4, Switzerland. brigitte.boeckmann@isb-sib.ch
Blatter
Marie-Claude
MC
Famiglietti
Livia
L
Hinz
Ursula
U
Lane
Lydie
L
Roechert
Bernd
B
Bairoch
Amos
A
D000595:Amino Acid Sequence; D051188:Knowledge Bases; D008969:Molecular Sequence Data; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
D011506:Proteins