title: [Lipids content in renal tissue membranes in patients with urolithiasis and secondary pyelonephritis].
abstract: We studied cytomembranes of the interstitial tissue of renal medullary layer obtained by lifetime biopsy of renal tissue in the course of pyelolithotomy in 46 patients with urolithiasis and secondary pyelonephritis. Biopsy structure was controlled with histological methods using standard staining. Basic phospholipids and cholesterol fractions in renal tissue cytomembranes were assayed at thin layer chromatography. The findings show significant changes in a nephron cytomembrane lipid phase in patients with urolithiasis and secondary pyelonephritis. There was a structural rearrangement of lipid biolayer of renal tissue cell membranes in response to microbial inflammation. Thus, use of membrane-stabilising drugs are grounded in patients with secondary pyelonephritis and urolithiasis.
authors.forename: N I
authors.initials: NI
authors.lastname: Kazeko
authors.forename: V A
authors.initials: VA
authors.lastname: Zhmurov
authors.forename: A A
authors.initials: AA
authors.lastname: Borovskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Veshkurtsev
authors.forename: O V
authors.initials: OV
authors.lastname: Khvan
mesh_terms: D006801:Humans; D007679:Kidney Medulla / Q000737:chemistry / Q000473:pathology; D008563:Membrane Lipids / Q000032:analysis*; D011704:Pyelonephritis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D014545:Urinary Calculi / Q000737:chemistry* / Q000150:complications / Q000473:pathology
chemical_list: D008563:Membrane Lipids