Synthesis of complex-type glycans derived from parasitic helminths.
Chemical synthesis of complex-type glycans 1 and 2 derived from eggs of parasitic helminths, Schistosoma mansoni and Schistosoma japonicum, is described. These branched sugar chains were synthesized regio- and stereoselectively by using beta-mannosylation, desilylation under high pressure, and glycosylation in frozen solvent as key transformations.
Nakano
Jun
J
RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama 351-0198, Japan.
Ohta
Hiromichi
H
Ito
Yukishige
Y
D000818:Animals; D002236:Carbohydrate Conformation; D006031:Glycosylation; D006376:Helminths / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D011312:Pressure; D012549:Schistosoma japonicum / Q000737:chemistry*; D012550:Schistosoma mansoni / Q000737:chemistry*; D013237:Stereoisomerism
D011134:Polysaccharides; D008358:Mannose