title: Significance of phrenic nerve electrophysiological abnormalities in Guillain-Barré syndrome.
abstract: The authors investigated whether the amplitude and latency of diaphragm compound muscle action potential helped predict respiratory failure in Guillain-Barré syndrome. Both variables were significantly but weakly correlated with vital capacity (VC) and were similar in unventilated (n = 60) and ventilated (n = 10) patients. In ventilated patients, motor loss severity, progression, and VC reduction were significantly greater, and bulbar dysfunction was more common. Predicting respiratory failure must rely on clinical features and VC.
authors.affiliation: Functional Testing Department, Raymond Poincaré Teaching Hospital, Garches, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Durand
authors.forename: H
authors.initials: H
authors.lastname: Prigent
authors.forename: V
authors.initials: V
authors.lastname: Sivadon-Tardy
authors.forename: D
authors.initials: D
authors.lastname: Orlikowski
authors.forename: C
authors.initials: C
authors.lastname: Caudie
authors.forename: C
authors.initials: C
authors.lastname: Devaux
authors.forename: B
authors.initials: B
authors.lastname: Clair
authors.forename: J-L
authors.initials: JL
authors.lastname: Gaillard
authors.forename: F
authors.initials: F
authors.lastname: Lofaso
authors.forename: J-C
authors.initials: JC
authors.lastname: Raphael
authors.forename: T
authors.initials: T
authors.lastname: Sharshar
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D003964:Diaphragm / Q000294:innervation / Q000503:physiopathology*; D018450:Disease Progression; D004568:Electrodiagnosis / Q000379:methods; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D018908:Muscle Weakness / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D010791:Phrenic Nerve / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D012125:Respiratory Center / Q000503:physiopathology; D012131:Respiratory Insufficiency / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D014797:Vital Capacity / Q000502:physiology