title: Local axon guidance in cerebral cortex and thalamus: are we there yet?
abstract: Normal brain function requires the development of precise connections between thalamus and cerebral cortex. In this issue of Neuron, Cang et al. and Tori and Levitt argue that EphA/ephrin-A signaling in the target tissue guides sensory thalamic axons to the correct cortical area, and sensory cortical axons to precise thalamic targets. Although EphA/ephrin-A signaling organizes sensory maps within areas, and thalamocortical axons in the internal capsule, both papers argue that each developmental event is dissociable from the others.
authors.affiliation: Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, Illinois 60637.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Grove
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D036342:Ephrins / Q000378:metabolism; D009434:Neural Pathways / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013788:Thalamus / Q000502:physiology*
chemical_list: D036342:Ephrins