title: Early dural reaction to polylactide in cranial defects in rabbits.
abstract: Restoring the bone integrity to injured calvariae remains a challenge to surgeons. In this study, the dural biocompatibility of biodegradable poly-L/DL-lactide 80/20 and 70/30 defect covers, designed for guided bone regeneration, was assessed. In each of the 16 test rabbits, bilateral (8.3 mm) cranial defects were created. The different covers were applied to one defect each in every rabbit and consisted of three parts: an epicranial cover, a spacer, and a dural cover. All defects had closed after 8 weeks due to new bone formation. A few giant cells were found at the cover-to-dura interface in equal numbers for both covers. Dural bone formation was present in 15 of 16 rabbits and progressed unhindered by the defect cover or its early degradation products.
authors.affiliation: AO Research Institute, Davos, and Clinic for Reconstructive Surgery, Division of Cranio-Maxillofacial Surgery, University Hospital, Basel, Switzerland.
authors.forename: Andreas A
authors.initials: AA
authors.lastname: Mueller
authors.forename: Berton A
authors.initials: BA
authors.lastname: Rahn
authors.forename: Sylwester
authors.initials: S
authors.lastname: Gogolewski
authors.forename: Christoph S
authors.initials: CS
authors.lastname: Leiggener
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001861:Bone Regeneration; D003238:Connective Tissue / Q000378:metabolism; D004388:Dura Mater / Q000601:surgery*; D005260:Female; D015743:Giant Cells, Foreign-Body / Q000378:metabolism; D008856:Microscopy, Fluorescence; D010294:Parietal Bone / Q000601:surgery*; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D011091:Polyesters; C033616:poly(lactide)