title: [Concept of a probiotic preparation, containing original microbial metabolites].
abstract: The biological functions of Escherichia coli M-17 exometabolites, contained in the synthetic composition of the autostimulating preparation "Actoflor-C", were evaluated. As shown by in vitro experiments, the composition had higher stimulating activity with respectto some microorganisms of the normal microflora, in comparison with the prototype preparation "Actoflor". High doses of the preparation "Actoflor-C" were supposedly capable of having not only positive influence on the development of microbiocenosis, but also of producing therapeutic action and primarily on intestinal epithelial cells by compensating the insufficient supply of bacterial metabolites in dysbiotic states. The presented data made it possible to believe that the functional activity of microbiocenosis was greatly determined by the system of metabolic regulation. The presented results formed the basis for the use of bacterial metabolites in the therapeutic of microbiocenosis in man.
authors.forename: T Ia
authors.initials: TIa
authors.lastname: Vakhitov
authors.forename: L N
authors.initials: LN
authors.lastname: Petrov
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
mesh_terms: D001419:Bacteria / Q000378:metabolism; D018407:Bacterial Physiological Phenomena / Q000187:drug effects; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology*; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000382:microbiology; D019936:Probiotics / Q000494:pharmacology*
chemical_list: D001685:Biological Factors