title: [A case of advanced gastric cancer with direct invasion of the transverse colon responding to paclitaxel/5'-DFUR combined therapy].
abstract: A 50-year-old man was diagnosed with non-resectable scirrhous gastric cancer of antrum accompanied with colon ileus due to direct invasion of the transverse colon. As the ileus improved after cecostomy, chemotherapy with TS-1/cisplatin(CDDP) was performed. Because of no response, 4 cycles of paclitaxel (PTX)/doxifluridine (5'-DFUR) therapy was performed as second-line chemotherapy. Since the stenosis of transverse colon dilated completely and the tumor disappeared, we performed total gastrectomy and right hemicolectomy, and could resect completely. Though 2 cycles of PTX/5'-DFUR therapy was performed postoperatively and the patient's postoperative condition was good, he was suffering from carcinomatous peritonitis complicated by ileus and obstructive jaundice 4 months after operation. He died 1 year after the first medical examination, but his QOL was fairly good for 10 months. PTX/5'-DFUR therapy, which has only slight complications, may be useful for patients with recurrent gastric cancer who had been treated with 5-FU administration as first-line chemotherapy. But the future problem was how to control dissemination after surgery in a resectable case after chemotherapy.
authors.affiliation: Dept. of Surgery, Tsukazaki Hospital.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Fujio
authors.forename: Toshio
authors.initials: T
authors.lastname: Ihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takatori
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsukazaki
authors.forename: Ikuho
authors.initials: I
authors.lastname: Koyama
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Tsukazaki
authors.forename: Harushi
authors.initials: H
authors.lastname: Osugi
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D044684:Colon, Transverse / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D004334:Drug Administration Schedule; D005467:Floxuridine / Q000008:administration & dosage; D006801:Humans; D045823:Ileus / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000556:secondary; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D005467:Floxuridine; D017239:Paclitaxel; C025034:doxifluridine