title: Recent advances in array comparative genomic hybridization technologies and their applications in human genetics.
abstract: Array comparative genomic hybridization (array CGH) is a method used to detect segmental DNA copy number alterations. Recently, advances in this technology have enabled high-resolution examination for identifying genetic alterations and copy number variations on a genome-wide scale. This review describes the current genomic array platforms and CGH methodologies, highlights their applications for studying cancer genetics, constitutional disease and human variation, and discusses visualization and analytical software programs for computational interpretation of array CGH data.
authors.affiliation: Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver BC, Canada V5Z 1L3. wlockwood@bccrc.ca
authors.forename: William W
authors.initials: WW
authors.lastname: Lockwood
authors.forename: Raj
authors.initials: R
authors.lastname: Chari
authors.forename: Bryan
authors.initials: B
authors.lastname: Chi
authors.forename: Wan L
authors.initials: WL
authors.lastname: Lam
mesh_terms: D018628:Gene Dosage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006801:Humans; D009693:Nucleic Acid Hybridization / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software
chemical_list: D005819:Genetic Markers