Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation.
Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC(50) values of 2.9 and 1.7 microM, respectively, and they also inhibited cell-mediated LDL oxidation more than 5 times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 microM. Compound (1) had no effect on the anti-atherogenesis in low-density lipoprotein receptor-deficient mice.
Kang
Hyun-Mi
HM
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.
Ryong Kim
Ju
J
Jeomg
Tae-Sook
TS
Choi
Sung-Gyu
SG
Ryu
Young-Han
YH
Taeg Oh
Goo
G
Baek
Nam-In
NI
Kwon
Byoung-Mog
BM
D029661:Alnus / Q000737:chemistry; D000818:Animals; D006536:Heptanes / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D010084:Oxidation-Reduction; D017392:Thiobarbituric Acid Reactive Substances
D006536:Heptanes; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances