title: Ribonucleic guanidine demonstrates an unexpected marked preference for complementary DNA rather than RNA.
abstract: Replacement of the phosphodiester linkages of DNA and RNA by guanidinium linkages provides DNG and RNG. We report here the order of stability of mixed duplexes (RNG-U5.DNA-A5>>RNA-U5.RNA-A5>RNG-U5.RNA-A5>RNA-U5.DNA-A5>DNA-T5.DNA-A5). The considerable stability of RNG.DNA compared to RNG.RNA is shown to be due to the rigid backbone of RNG existing only in B-form and therefore lowering its affinity for A-RNA. RNG oligomers are putative antigene agents which are specific for DNA and would have minimal competitive binding to ncRNA.
authors.affiliation: Department of Chemistry and Biochemistry, University of California at Santa Barbara, CA 93106, USA.
authors.forename: Myunji
authors.initials: M
authors.lastname: Park
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Toporowski
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Bruice
mesh_terms: D001667:Binding, Competitive; D002942:Circular Dichroism; D018076:DNA, Complementary / Q000737:chemistry* / Q000378:metabolism*; D019791:Guanidine / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009843:Oligoribonucleotides / Q000737:chemistry* / Q000378:metabolism; D014498:Uracil / Q000737:chemistry / Q000378:metabolism
chemical_list: D018076:DNA, Complementary; D009843:Oligoribonucleotides; D014498:Uracil; D019791:Guanidine