Cytotoxic sesquiterpene lactones from Saussurea calcicola.
Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8alpha-hydroxy-11alpha, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3beta-hydroxy-8alpha-epoxymethylacriloiloxy-4(15),10(14),11(13)-trien-guaian-6,12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23-1.72 microg/mL.
Choi
Sang Zin
SZ
Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Choi
Sang Un
SU
Lee
Kang Ro
KR
D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes