Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines.
A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).
Hui
Xu
X
Laboratoire de Pharmacognosie et Groupe Chimiothérapie Antiparasitaire (associé au CNRS-BioCIS) Faculté de Pharmacie, Université de Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France.
Desrivot
Julie
J
Bories
Christian
C
Loiseau
Philippe M
PM
Franck
Xavier
X
Hocquemiller
Reynald
R
Figadère
Bruno
B
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007893:Leishmania donovani / Q000187:drug effects; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects; D014346:Trypanosoma brucei brucei / Q000187:drug effects
D000981:Antiprotozoal Agents; D011810:Quinoxalines