title: Analysis of chemical warfare agents III. Use of bis-nucleophiles in the trace level determination of phosgene and perfluoroisobutylene.
abstract: The reactivity of phosgene and perfluoroisobutylene (PFIB) towards 1,2-bis-nucleophiles was exploited to allow determination of these gases in air samples. 2-Aminothiophenol (ATP), 3,4-dimercaptotoluene (DMT) and 2-hydroxymethylpiperidine (HMP) were evaluated as bis-nucleophiles capable of forming thermally-stable derivatives with phosgene and PFIB when loaded with triethylamine onto Tenax TA. Experimental design was used to optimise thermal desorption conditions. Detection limits in the low ngm(-3) range were observed for the five derivatives investigated. This work represents the most sensitive analytical method for trace level quantitation of phosgene and PFIB published to date.
authors.affiliation: Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. bmuir@dstl.gov.uk
authors.forename: Bob
authors.initials: B
authors.lastname: Muir
authors.forename: David B
authors.initials: DB
authors.lastname: Cooper
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Carrick
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Timperley
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Slater
authors.forename: Suzanne
authors.initials: S
authors.lastname: Quick
mesh_terms: D000388:Air / Q000032:analysis*; D000814:Aniline Compounds / Q000032:analysis; D002619:Chemical Warfare Agents / Q000032:analysis* / Q000737:chemistry; D005021:Ethylamines / Q000737:chemistry; D005466:Fluorocarbons / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D019570:Inhalation Exposure; D010705:Phosgene / Q000032:analysis*; D010880:Piperidines / Q000032:analysis; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000032:analysis; D014050:Toluene / Q000031:analogs & derivatives / Q000032:analysis
chemical_list: C502327:3,4-dimercaptotoluene; D000814:Aniline Compounds; D002619:Chemical Warfare Agents; D005021:Ethylamines; D005466:Fluorocarbons; D010880:Piperidines; D013438:Sulfhydryl Compounds; D010705:Phosgene; C005464:2-aminothiophenol; C016648:perfluoroisobutylene; D014050:Toluene; C016162:triethylamine