title: Three new dimeric benzofuran derivatives from the roots of Ligularia stenocephala MATSUM. et KOIDZ.
abstract: Three new dimeric benzofuran derivatives, ligulacephalins A (1), B (2) and C (3), were isolated from the roots of Ligularia stenocephala MATSUM. ET KOIDZ. (Compositae) together with three known compounds, 5,6-dimethoxy-2-isopropenylbenzofuran (4), euparin (5) and (R)-(-)-hydroxytremetone (6). The structures of the new compounds were determined by spectroscopic evidence. The chiral HPLC analysis demonstrated that 1-3 occurred as a racemate. The absolute configurations of each enantiomer from 1-3 were elucidated on the basis of circular dichroism (CD) data.
authors.affiliation: Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Toyoda
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yaoita
authors.forename: Masao
authors.initials: M
authors.lastname: Kikuchi
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; C507950:ligulacephalin A; C507951:ligulacephalin B; C507952:ligulacephalin C