title: Hippocampal and parahippocampal volumes in schizophrenia: a structural MRI study.
abstract: Smaller medial temporal lobe volume is a frequent finding in studies of patients with schizophrenia, but the relative contributions of the hippocampus and three surrounding cortical regions (entorhinal cortex, perirhinal cortex, and parahippocampal cortex) are poorly understood. We tested the hypothesis that the volumes of medial temporal lobe regions are selectively changed in schizophrenia. We studied 19 male patients with schizophrenia and 19 age-matched male control subjects. Hippocampal and cortical volumes were estimated using a three-dimensional morphometric protocol for the analysis of high-resolution structural magnetic resonance images, and repeated measures ANOVA was used to test for region-specific differences. Patients had smaller overall medial temporal lobe volumes compared to controls. The volume difference was not specific for either region or hemisphere. The finding of smaller medial temporal lobe volumes in the absence of regional specificity has important implications for studying the functional role of the hippocampus and surrounding cortical regions in schizophrenia.
authors.affiliation: Schizophrenia and Bipolar Disorders Program, McLean Hospital/Harvard Medical School, Mill Street, Belmont, MA, 02478, USA. ksim@mclean.harvard.edu
authors.forename: Kang
authors.initials: K
authors.lastname: Sim
authors.forename: Iain
authors.initials: I
authors.lastname: DeWitt
authors.forename: Tali
authors.initials: T
authors.lastname: Ditman
authors.forename: Martin
authors.initials: M
authors.lastname: Zalesak
authors.forename: Ian
authors.initials: I
authors.lastname: Greenhouse
authors.forename: Donald
authors.initials: D
authors.lastname: Goff
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Weiss
authors.forename: Stephan
authors.initials: S
authors.lastname: Heckers
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000033:anatomy & histology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020534:Parahippocampal Gyrus / Q000033:anatomy & histology* / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*; D013702:Temporal Lobe / Q000033:anatomy & histology