title: An intervention study of smoking cessation with feedback on genetic cancer susceptibility in Japan.
abstract: BACKGROUND
  To evaluate whether feedback of genetic information regarding an L-myc polymorphism, identified as impacting on tobacco-related cancer risk, has an influence on smoking cessation, an intervention study was conducted.
  
  
  METHODS
  We recruited smokers from first-visit outpatients at Aichi Cancer Center Hospital. Six hundred and seventeen participated and were allocated into two groups: the biomarker feedback group (BF) and the follow-up smoking status group (FS). The subjects were asked for their smoking status at enrolment and at 3- and 9-month follow-ups. BF subjects were notified about their L-myc genotype.
  
  
  RESULTS
  The smoking cessation rate at 9-month follow-up was essentially the same for both BF and FS cases, at 18.8% and 17.0%, respectively (P = 0.798). However, a difference in the rate was evident with non-cancer subjects (12.7% and 8.4%, respectively, P = 0.237), especially in females (15.0% and 4.2%, respectively, P = 0.024). The non-cancer subjects informed of their genotype were more likely to quit smoking than the FS patients; particularly in those having a risky genotype, this was significant (odds ratio: 2.87, P = 0.003). Again it was most prominent in females.
  
  
  CONCLUSIONS
  Feedback regarding an L-myc polymorphism did not impact on smoking cessation overall but appeared to benefit smokers without cancer. In addition, gender could affect the response to the feedback.
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusaku Nagoya, Japan. hidemi@aichi-cc.jp
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ito
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Toshiko
authors.initials: T
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kumimoto
authors.forename: Katashi
authors.initials: K
authors.lastname: Okuma
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016259:Genes, myc; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology*; D005820:Genetic Testing; D006801:Humans; D007564:Japan; D007721:Knowledge of Results, Psychological; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control / Q000523:psychology; D011110:Polymorphism, Genetic; D016540:Smoking Cessation
chemical_list: D005819:Genetic Markers