Inactivation of human angiotensin converting enzyme by copper peptide complexes containing ATCUN motifs.
The copper complex [KGHK-Cu]+ demonstrates catalytic inactivation of human angiotensin converting enzyme at sub-saturating concentrations, under oxidative conditions, with an observed rate constant k approximately 2.9 +/- 0.5 x 10(-2) min(-1).
Gokhale
Nikhil H
NH
Evans Laboratory of Chemistry, The Ohio State University, Columbus, 43210, USA.
Cowan
J A
JA
D020816:Amino Acid Motifs; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry* / Q000378:metabolism*
D000806:Angiotensin-Converting Enzyme Inhibitors; D010455:Peptides; D003300:Copper; D007703:Peptidyl-Dipeptidase A