title: Primary lymphoblastic B-cell lymphoma of the cranial dura mater: a case report and review of the literature.
abstract: Primary lymphomas of the cranial dura mater are rare. Mucosa-associated lymphoid tissue extranodal marginal zone lymphomas are the most common subtype of non-Hodgkin's lymphomas that present as primary cranial dura tumors. A 33 year-old male presented with a 3-month history of a growing lump in the right frontal area. Neuroimaging studies demonstrated an extra-axial, broad-based mass with a dural tail in the right frontal bone convexity. Biopsy led to the diagnosis of localized dural precursor B-cell lymphoblastic lymphoma. The patient was treated with a combination of chemotherapy and radiotherapy, achieving durable disease-free survival. This is the first report of precursor B-cell lymphoblastic lymphoma of dura mater. A review of the literature on primary lymphomas of cranial dura mater is presented. Primary lymphomas of the cranial dura mater are rare. Mucosa-associated lymphoid tissue extranodal marginal zone lymphomas are the most common subtype of non-Hodgkin's lymphomas that present as primary cranial dura tumors. A 33 year-old male presented with a 3-month history of a growing lump in the right frontal area. Neuroimaging studies demonstrated an extra-axial, broad-based mass with a dural tail in the right frontal bone convexity. Biopsy led to the diagnosis of localized dural precursor B-cell lymphoblastic lymphoma. The patient was treated with a combination of chemotherapy and radiotherapy, achieving durable disease-free survival. This is the first report of precursor B-cell lymphoblastic lymphoma of dura mater. A review of the literature on primary lymphomas of cranial dura mater is presented.
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, University of Miami/Sylvester Cancer Center, Miami, FL 331396, USA.
authors.forename: Sakher
authors.initials: S
authors.lastname: Abdullah
authors.forename: Daniel
authors.initials: D
authors.lastname: Morgensztern
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Rosado
authors.forename: Izidore S
authors.initials: IS
authors.lastname: Lossos
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D004388:Dura Mater / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell; D008279:Magnetic Resonance Imaging; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D018714:Radiotherapy, Adjuvant
chemical_list: D000970:Antineoplastic Agents