Are vanadium compounds drugable? Structures and effects of antidiabetic vanadium compounds: a critical review.
Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.
Scior
Thomas
T
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Autónoma de Puebla, Av. 14 Sur y Av. San Claudio, Col, San Manuel, Puebla, Pue, México. tscior@siu.buap.mx
Guevara-García
Antonio
A
Bernard
Philippe
P
Do
Quoc-Tuan
QT
Domeyer
David
D
Laufer
Stefan
S
D000595:Amino Acid Sequence; D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017968:Vanadium Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity
D002614:Chelating Agents; D007004:Hypoglycemic Agents; D017968:Vanadium Compounds