title: Malignant peripheral nerve sheath tumor originating in neurofibroma of the mesentery. Case report.
abstract: An 83-year-old woman was admitted to our hospital because of colicky pain under the right costal arch suggesting cholecystitis. Physical examination confirmed by ultrasound scan indicated a palpable tumor in that location. Laparotomy was performed and the tumor was removed. Histopathological examination revealed malignant peripheral nerve sheath tumor (MPNST) originating in neurofibroma of the mesentery. Macroscopic, histological and cytological features were typical for MPNST. High nuclear pleomorphism, hyperchromasia were observed but on average only two mitotic figures per high power field were seen. The growth fraction determined by Ki-67 immunoreactivity was about 30%. Immunohistochemical stains revealed positivity of individual cells for NK-1(CD57), S-100 protein and NSE. It was lack of positivity for cytokeratin, EMA, vimentin, desmin, SMA, CD34. We report a well documented case of MPNST originating in preexisting neurofibroma of the mesentery. To our knowledge, is the first case in the Polish literature.
authors.affiliation: Department of Pathomorphology, District Hospital, Konin.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Górecki
authors.forename: Magdalena
authors.initials: M
authors.lastname: Ostrowska
authors.forename: Barbara
authors.initials: B
authors.lastname: Kaszuba
authors.forename: Przemysław
authors.initials: P
authors.lastname: Nowicki
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dudzik
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wojnowski
mesh_terms: D000369:Aged, 80 and over; D018959:CD57 Antigens / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008643:Mesentery / Q000378:metabolism / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology*; D009455:Neurofibroma / Q000378:metabolism / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D018959:CD57 Antigens; D019394:Ki-67 Antigen; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase