title: A comparison of two botulinum type a toxin preparations for the treatment of glabellar lines: double-blind, randomized, pilot study.
abstract: BACKGROUND
  Botulinum toxins have been proven effective for reducing facial lines. There are two commercial types of botulinum toxin type A available in many countries but no published comparison studies.
  
  
  OBJECTIVE
  To compare the efficacy and tolerability of Botox Cosmetic and Dysport 50 U in the treatment of glabellar lines (using 20 U of Botox Cosmetic, which is the dose approved by the US Food and Drug Administration for the treatment of glabellar lines, and 50 U of Dysport, which has been reported to be the optimal dose for this formulation).
  
  
  METHODS
  Parallel-group double-blind pilot study. Evaluation by observing physician, photographic, and patient evaluations.
  
  
  CONCLUSIONS
  Botox 20 U provided better and more prolonged efficacy than Dysport 50 U in the treatment of glabellar lines.
authors.affiliation: Cranley Clinic, London, UK.
authors.forename: Philippa L
authors.initials: PL
authors.lastname: Lowe
authors.forename: Rickie
authors.initials: R
authors.lastname: Patnaik
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Lowe
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000494:pharmacology*; D010865:Pilot Projects; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A