title: Comparison of capsule endoscopy with ileocolonoscopy for detecting small-bowel lesions in patients with seronegative spondyloarthropathies.
abstract: OBJECTIVE
  Patients with spondyloarthropathies are often found to have signs of small-bowel inflammation when examined by ileocolonoscopy. Because capsule endoscopy has been found to be superior to other endoscopic and radiological modalities in the detection of small-bowel inflammation, we aimed to compare the diagnostic yield of capsule endoscopy with that of ileocolonoscopy in the detection of small-bowel lesions in patients with spondyloarthropathies.
  
  
  METHODS
  Twenty patients with documented seronegative peripheral arthritis, ankylosing spondylitis, or sacroiliitis, who had not taken nonsteroidal anti-inflammatory drugs (NSAIDs) in the preceding 2 months, participated in the study. The patients underwent capsule endoscopy, followed by ileocolonoscopy within 7 days, with blinded assessment of both examinations. Biopsies were taken when indicated and adverse events were monitored. Patients completed a questionnaire on their satisfaction with the two procedures.
  
  
  RESULTS
  A total of 20 patients (11 men, 9 women; mean age 41+/-13 years) with seronegative inflammatory spondyloarthropathies but without abdominal complaints completed the study. No adverse effects were reported and all the capsules were excreted. Of these 20 patients, 11 (55%) had a normal small bowel on both examinations. Significant small-bowel findings (erythema, mucosal breaks, aphthous or linear ulcers, erosions) were detected by capsule endoscopy in six patients (30%) and by ileocolonoscopy in only one patient. In addition, capsule endoscopy detected significant upper gastrointestinal pathology in 40% of patients. The patients preferred capsule endoscopy to ileocolonoscopy.
  
  
  CONCLUSIONS
  Capsule endoscopy detected more small-bowel lesions than ileocolonoscopy, and provided additional potentially relevant information on upper gastrointestinal pathology in patients with spondyloarthropathies.
authors.affiliation: Department of Gastroenterology and Rheumatology, Rambam Medical Center, Haifa, Israel. r_eliakim@rambam.health.gov.il
authors.forename: R
authors.initials: R
authors.lastname: Eliakim
authors.forename: A
authors.initials: A
authors.lastname: Karban
authors.forename: D
authors.initials: D
authors.lastname: Markovits
authors.forename: E
authors.initials: E
authors.lastname: Bardan
authors.forename: S
authors.initials: S
authors.lastname: Bar-Meir
authors.forename: D
authors.initials: D
authors.lastname: Abramowich
authors.forename: E
authors.initials: E
authors.lastname: Scapa
mesh_terms: D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D003108:Colonic Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D003113:Colonoscopy / Q000379:methods; D015897:Comorbidity; D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012698:Serologic Tests; D017678:Sex Distribution; D025242:Spondylarthropathies / Q000175:diagnosis / Q000453:epidemiology*