Free-radical-scavenging and xanthine oxidase inhibitory constituents from Stereospermum personatum.
Bioassay-guided fractionation of different extracts of both stem and stem bark of Stereospermum personatum led to the isolation of free-radical-scavenging and xanthine oxidase inhibitory molecules along with three new anthraquinones, sterequinones F-H (1-3), a new naphthoquinone, sterequinone I (4), two new phenethyl esters, 2(4'-hydroxyphenyl)ethyl undecanoate (14) and 2(4'-hydroxyphenyl)ethyl nonacosanoate (15), and a new 3,4,5-trimethoxycinnamyl ether, 2-methoxy-4-[3'-(3'',4'',5''trimethoxyphenyl)allyloxymethyl]phenol (16), together with known compounds. The antioxidant and xanthine oxidase inhibitory potentials of the isolated compounds are reported.
Kumar
U Sampath
US
Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Tiwari
Ashok K
AK
Reddy
S Venkat
SV
Aparna
P
P
Rao
R Jagadeeshwar
RJ
Ali
A Zehra
AZ
Rao
J Madhusudana
JM
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007194:India; D008515:Medicine, Ayurvedic; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D000880:Anthraquinones; D000975:Antioxidants; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D009285:Naphthoquinones; C506378:sterequinone F; C506380:sterequinone G; C506379:sterequinone H; C506381:sterequinone I; D014969:Xanthine Oxidase