title: Blood clot dissolution dynamics simulation during thrombolytic therapy.
abstract: Nonocclusive blood clots only partially fill blood vessels and together with the adjacent vessel wall form a channel through which blood flows at usually much higher velocities than in normal vessels. Our aim was to find a theoretical explanation for the experimentally observed fact that fast flowing blood through the channel has a large effect on the increase of the clot dissolution rate compared to the dissolution rate in the absence of flow. Blood flow through the channel increases transport of dissolution agents to the clot and also exerts large forces to the surface of the clot along the channel. Proposed is a model for clot dissolution which assumes that the clot dissolution rate is proportional to the forces of flowing blood to the surface of the clot multiplied by the average blood velocity. The model has been verified by fitting to experimental magnetic resonance imaging data obtained by dynamical magnetic resonance microscopy of clots dissolved by recombinant tissue plasminogen activator in an artificial blood flow system.
authors.affiliation: JoZef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.
authors.forename: Igor
authors.initials: I
authors.lastname: Sersa
authors.forename: Gregor
authors.initials: G
authors.lastname: Tratar
authors.forename: Ales
authors.initials: A
authors.lastname: Blinc
mesh_terms: D000465:Algorithms; D001777:Blood Coagulation / Q000502:physiology*; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015233:Models, Statistical; D012995:Solubility; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000737:chemistry
chemical_list: D010959:Tissue Plasminogen Activator