Astroglial distribution and sexual differences in neural metabolism in mammillary bodies.
The sexual differences in cerebral nuclei are produced by the organizational and the activational function of gonadal hormones. The different performances by male and female rats in memory tasks requiring use of the mammillary bodies (MBs), could be due to structural and functional sexual dimorphic differences. Our work quantifies the number of glial fibrillary acidic protein immunoreactive (GFAP-IR) astrocytes, and neuronal metabolic activity measured by the cytochrome oxidase (CO) histochemistry in the MBs in rats of both sexes. We find that there is no difference in astroglial number in the medial mammillary nucleus (MMN) and in the lateral mammillary nucleus (LMN) of males, females in estrus and diestrus adult rats. However, we do find statistically significant differences between the sexes in the neuronal oxidative metabolism influenced by the estrous cycle. We, therefore, conclude that there are functional and not structural sex differences in the MBs.
Blanco
Eduardo
E
Laboratorio de Psicobiología, Facultad de Psicología, Universidad de Oviedo, Plaza Feijoo, s/n, CP 33003 Oviedo, Spain. Edu_Blanco_Calvo.uo@uniovi.es
Picón
Isabel M
IM
Miranda
Ruben
R
Begega
Azucena
A
Conejo
Nélida M
NM
Arias
Jorge L
JL
D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D008297:Male; D008326:Mammillary Bodies / Q000166:cytology* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D014018:Tissue Distribution
D005904:Glial Fibrillary Acidic Protein; D003576:Electron Transport Complex IV