Five labdane diterpenoids from the seeds of Aframomum zambesiacum.
Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC(50) value of 4.97 microM.
Kenmogne
Marguerite
M
Department of Chemistry, Faculty of Science, University of Dschang, Box 67, Dschang, Cameroon.
Prost
Elise
E
Harakat
Dominique
D
Jacquier
Marie-José
MJ
Frédérich
Michel
M
Sondengam
Lucas B
LB
Zèches
Monique
M
Waffo-Téguo
Pierre
P
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000145:classification / Q000627:therapeutic use; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D030521:Zingiberaceae / Q000737:chemistry*
D000962:Antimalarials; D004224:Diterpenes; C433017:labdane