[Effect of alpha-tocopherol and its derivatives on actinomycin D induced apoptosis of rat thymocytes].
The induction of rat thymocyte apoptosis by actinomycin D was associated with the increased caspase-3 activity and DNA fragmentation, the both effects were attenuated by alpha-tocopherol. Apoptosis was also decreased by alpha-tocopheryl acetate, but these suppressive effects were less than those of alpha-tocopherol. Tocopheryl quinone had no pronounced antiapoptotic effect. It was proposed that the difference in antiapoptotic effects of alpha-tocopherol derivatives is attributed to structure properties of the chroman head group and to the ability for scavenging reactive oxygen species but it is not excluded that antiapoptotic activity of alpha-tocopherol may exceed that of a mere antioxidant.
Petrova
G V
GV
Donchenko
G V
GV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D053938:DNA Fragmentation / Q000187:drug effects; D003609:Dactinomycin / Q000494:pharmacology*; D005260:Female; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D003609:Dactinomycin; C002421:tocopherylquinone; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; D024502:alpha-Tocopherol; D024505:Tocopherols