Effect of prednisolone on secondary messenger metabolism in the lymphocytes from patients with acantholysis bullosa.
Prednisolone in therapeutic concentrations blocks Ca(2+) channels of lymphocyte plasma membranes and prevents arachidonic acid-induced Ca(2+) entry into the cells. Glucocorticoid virtually did not modulate arachidonic acid-stimulated release of Ca(2+) from intracellular stores. No appreciable effect of the hormone on mitogen-induced changes in the intracellular content of cAMP was detected.
Teplyuk
N P
NP
I. M. Setchenov Moscow Medical Academy.
Dukhanin
A S
AS
Ogurtsov
S I
SI
Belysheva
T S
TS
D016718:Arachidonic Acid / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004533:Egtazic Acid / Q000494:pharmacology; D004820:Epidermolysis Bullosa / Q000188:drug therapy*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D015290:Second Messenger Systems / Q000187:drug effects*
D016718:Arachidonic Acid; D004533:Egtazic Acid; D011239:Prednisolone; D000242:Cyclic AMP; D002118:Calcium