title: Rapid chloride analysis using miniaturised isotachophoresis.
abstract: A new design of miniaturised separation device for performing isotachophoresis (ITP) has been produced. The device contains a simple arrangement of channels comprising a single separation channel with a 'double T' injection geometry. The device was produced in poly(methyl methacrylate) and incorporates an on-column conductivity detector. A new electrolyte system was developed to enable the rapid determination of chloride to be made. This electrolyte system uses a leading ion of 3.5 mM nitrate at pH 3.0 with 0.5 mM indium(III) added as a complexing agent. Use of this electrolyte system with the new separation device allowed chloride samples to be analysed in under 100 s, with a limit of detection (LOD) calculated to be 2.2 mg l(-1).
authors.affiliation: School of Chemical Engineering and Analytical Science, The University of Manchester, UK. j.prest@manchester.ac.uk
authors.forename: Jeff E
authors.initials: JE
authors.lastname: Prest
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Baldock
authors.forename: Peter R
authors.initials: PR
authors.lastname: Fielden
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Goddard
authors.forename: Stephan
authors.initials: S
authors.lastname: Mohr
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: Treves Brown
mesh_terms: D002712:Chlorides / Q000032:analysis*; D004573:Electrolytes; D004586:Electrophoresis / Q000295:instrumentation / Q000379:methods*; D008904:Miniaturization; D009566:Nitrates
chemical_list: D002712:Chlorides; D004573:Electrolytes; D009566:Nitrates