title: Genomic and proteomic analysis of mammary tumors arising in transgenic mice.
abstract: Transforming growth factor-beta (TGF-beta) is the prototype of a large family of signaling molecules. TGF-beta signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-beta signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.
authors.affiliation: Department of Cancer Biology, Biostatistics Shared Resource, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Xie
authors.forename: Baogang J
authors.initials: BJ
authors.lastname: Xu
authors.forename: Agnieszka E
authors.initials: AE
authors.lastname: Gorska
authors.forename: Yu
authors.initials: Y
authors.lastname: Shyr
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Schwartz
authors.forename: Nikki
authors.initials: N
authors.lastname: Cheng
authors.forename: Shawn
authors.initials: S
authors.lastname: Levy
authors.forename: Brian
authors.initials: B
authors.lastname: Bierie
authors.forename: Richard M
authors.initials: RM
authors.lastname: Caprioli
authors.forename: Harold L
authors.initials: HL
authors.lastname: Moses
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D014408:Biomarkers, Tumor; D016000:Cluster Analysis; D018076:DNA, Complementary / Q000378:metabolism; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics / Q000379:methods*; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D011506:Proteins / Q000737:chemistry; D020543:Proteome; D040901:Proteomics / Q000379:methods*; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D016212:Transforming Growth Factor beta / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D011506:Proteins; D020543:Proteome; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta