Evidence for sensory prediction deficits in schizophrenia.
OBJECTIVE
Patients with schizophrenia experiencing delusions and hallucinations can misattribute their own actions to an external source. The authors test the hypothesis that patients with schizophrenia have defects in their ability to predict the sensory consequences of their actions.


METHODS
The authors measured sensory attenuation of self-produced stimuli by patients with schizophrenia and by healthy subjects.


RESULTS
Patients with schizophrenia demonstrated significantly less sensory attenuation than healthy subjects.


CONCLUSIONS
Patients with a diagnosis of schizophrenia have a dysfunction in their predictive mechanisms.
Shergill
Sukhwinder S
SS
Institute of Neurology, University College London. s.shergill@iop.kcl.ac.uk
Samson
Gabrielle
G
Bays
Paul M
PM
Frith
Chris D
CD
Wolpert
Daniel M
DM
D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology; D003702:Delusions / Q000175:diagnosis / Q000523:psychology; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D011601:Psychophysics; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D020886:Somatosensory Disorders / Q000175:diagnosis* / Q000523:psychology; D014110:Touch / Q000502:physiology*