title: The effect of estradiol valerate and dienogest combination on serum homocysteine levels in postmenopausal women: a clinical trial.
abstract: Several studies have verified that hormone replacement therapy (HRT) has protective effects on postmenopausal women's cardiovascular condition. However, highly significant recent studies have reported that women treated with HRT have more cardiovascular events than untreated women. An elevated homocysteine level is one important risk factor for cardiovascular disease (CVD). As a good indicator of CVD risk, we examined the changes in plasma homocysteine levels of postmenopausal women treated with HRT. In our study, we administered estradiol valerate (2 mg) and dionegest (2 mg) to 34 postmenopausal women recruited randomly from our menopause clinic, and measured plasma homocysteine levels of patients at baseline and after 3 and 6 months of therapy. The changes in plasma homocysteine levels of treated patients were not statistically significant (p = 0.241). Our results indicate that 6 months of estradiol valerate and dionegest therapy does not change homocysteine levels in postmenopausal women.
authors.affiliation: Lutfi Kirdar Kartal Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey. meltempirim@hotmail.com
authors.forename: Z Meltem
authors.initials: ZM
authors.lastname: Pirimoglu
authors.forename: Elif
authors.initials: E
authors.lastname: Aygun
authors.forename: Ramazan
authors.initials: R
authors.lastname: Dansuk
authors.forename: Inci
authors.initials: I
authors.lastname: Kucukercan
authors.forename: Orhan
authors.initials: O
authors.lastname: Unal
authors.forename: Cem
authors.initials: C
authors.lastname: Turan
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000517:prevention & control; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D015914:Estrogen Replacement Therapy; D005260:Female; D006710:Homocysteine / Q000097:blood / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017698:Postmenopause; D016896:Treatment Outcome
chemical_list: D006710:Homocysteine; C023635:dienogest; D004958:Estradiol; D009277:Nandrolone