title: Biomarker discovery using protein microarray technology platforms: antibody-antigen complex profiling.
abstract: Protein microarrays represent an important new tool in proteomic systems biology. This review focuses on the contributions of protein microarrays to the discovery of novel disease biomarkers through antibody-based assays. Of particular interest is the use of protein microarrays for immune response profiling, through which a disease-specific antibody repertoire may be defined. The antigens and antibodies revealed by these studies are useful for clinical assay development, with enormous potential to aid in diagnosis, prognosis, disease staging and treatment selection. The discovery and characterization of novel biomarkers specifically tailored to disease type and stage are expected to enable personalized medicine by facilitating preventative medicine, predictive diagnostics and individualized curative therapies.
authors.affiliation: Invitrogen Corporation, ProtoArray Services, ProtoArray Center, 688 East Main Street, Branford, CT 06405, USA. dawn.mattoon@invitrogen.com
authors.forename: Dawn
authors.initials: D
authors.lastname: Mattoon
authors.forename: Gregory
authors.initials: G
authors.lastname: Michaud
authors.forename: Janie
authors.initials: J
authors.lastname: Merkel
authors.forename: Barry
authors.initials: B
authors.lastname: Schweitzer
mesh_terms: D000485:Allergens / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology* / Q000378:metabolism*; D015551:Autoimmunity / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D040081:Protein Array Analysis / Q000379:methods*
chemical_list: D000485:Allergens; D000936:Antigen-Antibody Complex; D015415:Biomarkers