title: [Primary prophylaxis of cerebrovascular complications in patients with metabolic syndrome].
abstract: OBJECTIVE
  To study effects of antihypertensive therapy with bisoprolol and actovegin on cerebral perfusion in patients with metabolic syndrome.
  
  
  METHODS
  Thirty patients (18 women and 12 men) with metabolic syndrome and mild arterial hypertension took bisoprolol alone in a dose 5-10 mg/day, and fifteen patients received combined therapy (bisoprolol and actovegin) for 12 weeks. Before the study and 12 weeks later measurements were made of carbohydrate and lipid metabolism, single photon emission computed tomography investigated brain perfusion.
  
  
  RESULTS
  Improvement of brain perfusion was observed after both monotherapy with bisoprolol and its combination with actovegin.
  
  
  CONCLUSIONS
  Monotherapy with bisoprolol and bisoprolol combination with actovegin improved brain perfusion but the combination was more effective.
authors.forename: V B
authors.initials: VB
authors.lastname: Mychka
authors.forename: I E
authors.initials: IE
authors.lastname: Chazova
authors.forename: V V
authors.initials: VV
authors.lastname: Gornostaev
authors.forename: V B
authors.initials: VB
authors.lastname: Sergienko
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D017298:Bisoprolol / Q000008:administration & dosage / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000502:physiology; D050260:Carbohydrate Metabolism / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006418:Heme / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D013670:Sodium Pertechnetate Tc 99m; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D006418:Heme; C015646:Actovegin; D013670:Sodium Pertechnetate Tc 99m; D017298:Bisoprolol