title: Dysplastic ganglioneurocytoma with increased glucose metabolism: a heterotopia with unique histopathology.
abstract: A 1 year and 7 month old boy was incidentally found to have an intracranial mass lesion at the frontal base. The mass was 45 x 54 x 47 mm in size, contained a calcification, a few small cysts, and extended downward to the sphenoid sinus and upper pharynx. The signal intensity of the lesion on magnetic resonance imaging was iso-high on T1-weighted images, and slightly high on T2-weighted images, and it did not enhance with gadolinium injection. Although there was no obvious mass effect, 18F-fluorode-oxyglucose positron-emission tomography demonstrated increased uptake, and a surgical resection was performed suspecting a neoplastic lesion. Histologically, the lesion consisted of small to large anomalous neurons and glial cells but lacked normal cortical architecture. Cellularity was high in some portion with MIB-1 labeling index of 2%, but there was no cellular atypia suggestive of neoplasm. Therefore, this lesion was considered to be a dysplasia that does not fit into the previously described entity. We suggest this lesion would be better described as dysplastic ganglioneurocytoma.
authors.affiliation: Department of Neurosurgery, Gunma University Graduate School of Medicine, Gunma, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yako
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazato
authors.forename: J
authors.initials: J
authors.lastname: Hirato
authors.forename: M
authors.initials: M
authors.lastname: Tosaka
authors.forename: T
authors.initials: T
authors.lastname: Ohtani
authors.forename: S
authors.initials: S
authors.lastname: Ishiuchi
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D005729:Ganglioneuroma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D018306:Neurocytoma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D011877:Radionuclide Imaging
chemical_list: D005947:Glucose