A comparison of two botulinum type a toxin preparations for the treatment of glabellar lines: double-blind, randomized, pilot study.
BACKGROUND
Botulinum toxins have been proven effective for reducing facial lines. There are two commercial types of botulinum toxin type A available in many countries but no published comparison studies.


OBJECTIVE
To compare the efficacy and tolerability of Botox Cosmetic and Dysport 50 U in the treatment of glabellar lines (using 20 U of Botox Cosmetic, which is the dose approved by the US Food and Drug Administration for the treatment of glabellar lines, and 50 U of Dysport, which has been reported to be the optimal dose for this formulation).


METHODS
Parallel-group double-blind pilot study. Evaluation by observing physician, photographic, and patient evaluations.


CONCLUSIONS
Botox 20 U provided better and more prolonged efficacy than Dysport 50 U in the treatment of glabellar lines.
Lowe
Philippa L
PL
Cranley Clinic, London, UK.
Patnaik
Rickie
R
Lowe
Nicholas J
NJ
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000494:pharmacology*; D010865:Pilot Projects; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A