[Neuroprotective effect of N-acylethanolamines in chronic morphine dependence. II. Effect on the rat brain fatty acid composition].
The effect of N-acylethanolamines mixture (NAE) with saturated and unsaturated acyl chains on the fatty acid composition of the rat brain under chronic morphine dependence was investigated. Long-term administration of NAE reduced morphine-induced decrease of mono- and polyunsaturated fatty acids in the rat brain crude lipid extract. Furthermore, NAE restored the acyl chain spectrum, especially the content of docosahexaenoic acid in essential phospholipids--phosphatidylcholine and phosphatidylethanolamine. Pharmacological activity of NAE depended on a dose.
Hula
N M
NM
Marhitych
V M
VM
Klimashevs'kyĭ
V M
VM
Horid'ko
T M
TM
Artamonov
M V
MV
Zhukov
O D
OD
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002908:Chronic Disease; D004195:Disease Models, Animal; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D005227:Fatty Acids / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D009021:Morphine Dependence / Q000188:drug therapy* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D004983:Ethanolamines; D005227:Fatty Acids; C022203:N-acylethanolamines; D018696:Neuroprotective Agents