title: The effect of infection with Mycobacterium tuberculosis on T-cell activation and proliferation in patients with and without HIV co-infection.
abstract: Tuberculosis is the most common opportunistic infection in HIV-infected people living in developing countries and is believed to accelerate the progression of HIV disease. This effect may be mediated by increased immune activation. We measured levels of CD4 and CD8 T-lymphocyte activation and proliferation in control subjects, patients with HIV alone, TB alone and patients with HIV and TB co-infection. Our results indicate that TB (in the absence of HIV) increases T-lymphocyte proliferation but its effects are modest in comparison with the stimulation induced by HIV infection alone.
authors.affiliation: Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. villacian1@yahoo.com
authors.forename: Jorge S
authors.initials: JS
authors.lastname: Villacian
authors.forename: Guat Bee
authors.initials: GB
authors.lastname: Tan
authors.forename: Lian Fang
authors.initials: LF
authors.lastname: Teo
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Paton
mesh_terms: D015704:CD4 Antigens; D016827:CD8 Antigens; D049109:Cell Proliferation; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000150:complications / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens