Current ideas about applications of heat shock proteins in vaccine design and immunotherapy.
Heat shock proteins (HSPs), as molecular chaperones, perform critical functions in maintaining cell homeostasis. Certain HSPs in extra-cellular milieu are capable of modulating innate and adaptive immunity due to their ability to chaperone polypeptides and to interact with the host's immune system, particularly professional antigen presenting cells (APCs). This review summarizes the immunomodulating functions of HSPs and their potential applications in cancer immunotherapy.
Wang
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Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Li
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Yang
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Subjeck
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D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D015195:Drug Design; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000502:physiology*; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014612:Vaccines
D000951:Antigens, Neoplasm; D006360:Heat-Shock Proteins; D011993:Recombinant Fusion Proteins; D014612:Vaccines