Estrogen receptor binding and alkylating properties of A-ring aromatic 17,20- and 20,21-epoxy-norpregnanediols: potential target selective antitumour agents.
Gill
J C
JC
Department of Chemistry, University of Technology, Loughborough, Leics, UK.
Khan
S E
SE
Lockey
P M
PM
Marples
B A
BA
Traynor
J R
JR
D000970:Antineoplastic Agents; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004852:Epoxy Compounds; D004958:Estradiol / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D009650:Norpregnanes / Q000737:chemistry / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D009650:Norpregnanes; D011960:Receptors, Estrogen; D004958:Estradiol