IFITM1-mediated cell repulsion controls the initial steps of germ cell migration in the mouse.
In this issue of Developmental Cell, a novel mechanism for the initiation of germ cell migration in the mouse has been identified, based upon differential expression of interferon-inducible transmembrane proteins in the gastrula (Tanaka et al., 2005). Germ cells are displaced by a repulsion mechanism from the posterior mesoderm into the endoderm.
Wylie
Christopher
C
Division of Developmental Biology and Molecular and Developmental Biology Program, University of Cincinnati, Cincinnati Children's Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
D000818:Animals; D000943:Antigens, Differentiation; D002465:Cell Movement / Q000502:physiology*; D004622:Embryo, Mammalian / Q000502:physiology; D004707:Endoderm / Q000502:physiology; D005854:Germ Cells / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D008648:Mesoderm / Q000502:physiology; D051379:Mice
D000943:Antigens, Differentiation; D008565:Membrane Proteins; C462181:fragilis protein, mouse; C062010:leu-13 antigen