title: Autoimmune hepatitis and multiple sclerosis: a coincidental association?
abstract: In the present study we report, as part of a large multiple sclerosis (MS) cohort (1800 patients), three cases of untreated patients who developed autoimmune hepatitis (AIH). The prevalence of AIH in the general population is about 0.0169% and seems to be higher in our MS cohort (0.17%). We suggest that a liver biopsy should systematically be performed in untreated MS patients with a sustained increase of liver enzyme.
authors.affiliation: Department of Neurology, University of Lille, France. j-deseze@chru-lille.fr
authors.forename: J
authors.initials: J
authors.lastname: de Seze
authors.forename: V
authors.initials: V
authors.lastname: Canva-Delcambre
authors.forename: I
authors.initials: I
authors.lastname: Fajardy
authors.forename: S
authors.initials: S
authors.lastname: Delalande
authors.forename: T
authors.initials: T
authors.lastname: Stojkovic
authors.forename: E
authors.initials: E
authors.lastname: Godet
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D019693:Hepatitis, Autoimmune / Q000453:epidemiology*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta