Expression and function of cell cycle proteins in rheumatoid arthritis synovial tissue.
Rheumatoid Arthritis (RA) is a chronic disease characterised by synovial lining hyperplasia and progressive destruction of joint tissues. Experimental data suggests that abnormal alterations in the expression of proteins involved in maintaining homeostatic control of the cell cycle is involved in disease progression in RA. By contributing to the overgrowth of synovial tissue, factors such as dysregulated proliferation or reduced apoptosis of cells can directly influence the pathological outcome of RA.
Taranto
E
E
Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Melbourne, Australia.
Leech
M
M
D000818:Animals; D017209:Apoptosis; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000502:physiology*; D049109:Cell Proliferation; D018450:Disease Progression; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D011519:Proto-Oncogenes; D013583:Synovial Membrane / Q000473:pathology / Q000503:physiopathology*
D018797:Cell Cycle Proteins