title: Mathematical modeling of the myosin light chain kinase activation.
abstract: The mathematical model presented here describes the interactions among Ca2+, calmodulin (CaM), and myosin light chain kinase (MLCK) and consists of a kinetic scheme taking into account 7 reactions instead of 12 as proposed previously. We derive a system of 5 nonlinear ordinary differential equations. Solving it yields the prediction of active MLCK as a function of [Ca2+] whereby the active MLCK is defined to be proportional to the Ca4CaM.MLCK complex concentration. The model predictions are compared with other theoretical and experimental predictions of active MLCK as well as with the results of our previously proposed complex model.
authors.affiliation: Department of Physics, University of Maribor, Koroska cesta 160, SI-2000 Maribor, Slovenia. ales.fajmut@uni-mb.si
authors.forename: Ales
authors.initials: A
authors.lastname: Fajmut
authors.forename: Marko
authors.initials: M
authors.lastname: Jagodic
authors.forename: Milan
authors.initials: M
authors.lastname: Brumen
mesh_terms: D000465:Algorithms; D002118:Calcium / Q000502:physiology; D002147:Calmodulin / Q000378:metabolism; D004789:Enzyme Activation / Q000502:physiology; D031541:Fluorescence Resonance Energy Transfer; D007700:Kinetics; D015233:Models, Statistical; D009130:Muscle, Smooth / Q000201:enzymology; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism*
chemical_list: D002147:Calmodulin; D009219:Myosin-Light-Chain Kinase; D002118:Calcium