title: Atelocollagen punctal occlusion in dry eye patients.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of atelocollagen punctal occlusion for dry eye patients.
  
  
  METHODS
  Prospective noncomparative interventional case series.
  
  
  METHODS
  Atelocollagen was injected into the superior and inferior canaliculi of 52 eyes of 28 dry eye patients. Vital staining of the ocular surface, breakup time of tears (BUT), tear volume, and corneal epithelial permeability to fluorescein were examined before and 1, 2, 4, and 8 weeks after treatment.
  
  
  RESULTS
  Rose bengal stain, fluorescein stain, BUT, and corneal epithelial permeability to fluorescence were significantly improved 1 week after atelocollagen punctal occlusion, and the improvement was maintained for up to 8 weeks after treatment.
  
  
  CONCLUSIONS
  Atelocollagen punctal occlusion effectively improves ocular surface disorders in dry eye patients.
authors.affiliation: Meiwakai Medical Foundation, Miyata Eye Hospital, Miyakonojo, Miyazaki, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyata
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Otani
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyai
authors.forename: Ryohei
authors.initials: R
authors.lastname: Nejima
authors.forename: Shiro
authors.initials: S
authors.lastname: Amano
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen / Q000009:adverse effects / Q000627:therapeutic use*; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000503:physiopathology; D019573:Epithelium, Corneal / Q000378:metabolism; D005143:Eyelids / Q000187:drug effects*; D005260:Female; D019793:Fluorescein / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D015590:Fluorophotometry; D006801:Humans; D007765:Lacrimal Apparatus / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011446:Prospective Studies; D012395:Rose Bengal / Q000493:pharmacokinetics; D013666:Tears / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D005456:Fluorescent Dyes; D009883:Ophthalmic Solutions; C059821:atelocollagen; D012395:Rose Bengal; D003094:Collagen; D019793:Fluorescein