Cytotoxic properties of oligostilbenoids from the tree barks of Hopea dryobalanoides.
A new modified stilbene dimer, diptoindonesin D (1), was isolated from the acetone extract of the tree bark of Hopea dryobalanoides, together with seven known compounds, parviflorol (2), (-)-balanocarpol (3), heimiol A (4), hopeafuran (5), (+)-alpha-viniferin (6), vaticanol B (7) and (-)-hopeaphenol (8). Cytotoxic properties of compounds 1-8 were evaluated against murine leukemia P-388 cells. Compound 8 was found to be the most active with IC50 of 5.7 microM.
Sahidin
Department of Chemistry, Institut Teknologi Bandung, Indonesia.
Hakim
Euis H
EH
Juliawaty
Lia D
LD
Syah
Yana M
YM
bin Din
Laily
L
Ghisalberti
Emilio L
EL
Latip
Jalifah
J
Said
Ikram M
IM
Achmad
Sjamsul A
SA
D000818:Animals; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D018547:Plant Stems / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D014197:Trees; D014407:Tumor Cells, Cultured
D001578:Benzopyrans; D013267:Stilbenes; C459559:vaticanol C