title: [Histopathology after implantation of lid weights].
abstract: BACKGROUND
  Various implants are used to treat lagophthalmos in facial paralysis. The implantation of gold or platinum eyelid weights (lid loading) is being used increasingly. Histological changes have not yet been systematically examined in the implant capsule during explantation of the eyelid weight.
  
  
  METHODS
  Of 26 explanted implants, 18 implants in 17 patients were followed-up using light microscopy from 1997 to 2004. We semi-quantitatively evaluated the density of the inflammatory infiltrate and recorded the occurrence of foreign bodies in the tissue. The inflammatory infiltrate was also immunohistochemically examined to characterize cellular composition.
  
  
  RESULTS
  In the semi-quantitative examination of inflammatory infiltration density, 60% of the gold implants showed a moderately dense or dense inflammatory infiltrate, while there was moderately dense infiltration in only 12.5% of the platinum implants. The immunohistochemical examination revealed a mixed lymphocytic inflammatory infiltrate which tended to a preponderance of B lymphocytes (humoral response). This is typical of unspecific chronic inflammation.
  
  
  CONCLUSIONS
  Both gold and platinum are suitable for treating lagophthalmos, however, platinum has a higher density and better biocompatibility than gold.
authors.affiliation: Klinik für Hals-, Nasen-, Ohrenkrankheiten, Universitätsmedizin Berlin - Charité Campus Mitte. thomas.schrom@gmx.de
authors.forename: T
authors.initials: T
authors.lastname: Schrom
authors.forename: C
authors.initials: C
authors.lastname: Taege
authors.forename: G
authors.initials: G
authors.lastname: Wolf
authors.forename: A
authors.initials: A
authors.lastname: Reinhardt
authors.forename: H
authors.initials: H
authors.lastname: Scherer
mesh_terms: D019544:Equipment Failure Analysis; D005141:Eyelid Diseases / Q000534:rehabilitation*; D005158:Facial Paralysis / Q000534:rehabilitation*; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects; D019919:Prosthesis Implantation / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000209:etiology* / Q000473:pathology*; D016896:Treatment Outcome