Kinetics of interaction of local anesthetics with human serum albumin.
We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible process; equilibrium was attained within 1.5-4.5 h depending on chemical nature of local anesthetics.
Galenko-Yaroshevskii
A P
AP
Krasnodar Division of Southern Bureau, Russian Academy of Medical, Moscow.
Fistunenko
P N
PN
Dukhanin
A S
AS
D000779:Anesthetics, Local / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry; D002045:Bupivacaine / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008012:Lidocaine / Q000737:chemistry; D012709:Serum Albumin / Q000737:chemistry*; D013748:Tetracaine / Q000737:chemistry
D000779:Anesthetics, Local; D001562:Benzimidazoles; C507880:RU 353; C492532:RU-1117; D012709:Serum Albumin; D013748:Tetracaine; D008012:Lidocaine; D002045:Bupivacaine