Multivoxel magnetic resonance spectroscopy in gliomatosis cerebri.
Gliomatosis cerebri is a rare entity with non-specific clinical and conventional magnetic resonance imaging (MRI) findings; accurate diagnosis is a differential diagnostic challenge. MR spectroscopy has recently been introduced as a useful diagnostic tool for detection of this entity. We present a gliomatosis cerebri case in which we made the radiological diagnosis using the MR spectroscopy findings; the diagnosis was confirmed by subsequent biopsy and histopathologic evaluation. Multivoxel spectroscopy (CSI, PRESS, 1500/135) shows a marked increase in Cho/NAA (6.6), normal to mild increase in Cho/Cr (1.2), and marked decrease in NAA/Cr (0.2) compared with the normally appearing contralateral side (Cho/NAA: 0.8, Cho/Cr: 0.9, NAA/Cr: 1.2).
Uysal
E
E
Department of Radiology, Department of Neurosurgery and Department of Pathology, Sisli Etfal Hospital, Istanbul, Turkey. enderuysaltr@yahoo.com
Erturk
M
M
Yildirim
H
H
Karatag
O
O
Can
M
M
Tanik
C
C
Basak
M
M
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001706:Biopsy; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis*; D013238:Stereotaxic Techniques
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline