Evaluation of osteogenic and chondrogenic activities of prefabricated periallografts.
Reconstruction of cartilage and bone defects has always been a challenging problem for the surgeon. Basic elements that are responsible for the repair process of these tissues are periost and perichondrium. Although several methods for the use of periost and perichondrium are proposed in the literature, the osteogenic and chondrogenic capacities of these tissues were shown to be the most important factor for a successful outcome. Bone and cartilage formation in acellular dermal matrix (ADM) prefabricated with periost and perichondrium was studied in 20 New Zealand rabbits. Morphologic and histologic evaluation and comparison of the newly formed tissues were evaluated. Four rabbits were excluded from the study because of infection, and specimens were obtained at 4, 6, 8, and 12 weeks after the study began from the remaining 16 rabbits. A gradual increase in bone and cartilage tissue formation through the 4th to 12th weeks was documented by reason of perichondrium and periost activation infiltrating into acellular dermal allografts. In view of the data obtained, it was concluded that periost or perichondrium prefabricated over ADM may be an alternative technique of cartilage and bone formation that may provide adequate tissue with elastic and osteo- and chondroconductive properties for the reconstruction of challenging defects.
Ozdemir
Ragip
R
Plastic and Reconstructive Surgery Clinic Hospital, Ankara, Turkey. ragipoya(5)@hotmail.com
Ulusoy
M Gurhan
MG
Kocer
Ugur
U
Karaaslan
Onder
O
Sahin
Belma
B
Culha
Emre
E
Bayiz
Unal
U
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001857:Bone Matrix / Q000473:pathology; D016025:Bone Transplantation / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology; D002356:Cartilage / Q000473:pathology / Q000502:physiology / Q000637:transplantation*; D020219:Chondrogenesis / Q000502:physiology*; D003094:Collagen / Q000627:therapeutic use; D018919:Neovascularization, Physiologic / Q000502:physiology; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology*; D010521:Periosteum / Q000637:transplantation; D011817:Rabbits; D019651:Plastic Surgery Procedures; D013997:Time Factors; D014184:Transplantation, Homologous
C440568:Alloderm; D001672:Biocompatible Materials; D003094:Collagen