title: Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium.
abstract: Inotropic responses to 5-hydroxytryptamine (5-HT) in human and porcine atrium can fade, suggesting 5-HT(4) receptor desensitization. De Maeyer et al., however, show in this issue that inhibition of phosphodiesterases with isobutyl-methyl-xanthine prevents fading of 5-HT(4) receptor-mediated responses to 5-HT and the partial agonist prucalopride in porcine atrium.
authors.affiliation: Department of Physiology, University of Cambridge, CB2 3EG Cambridge, UK.
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Kaumann
authors.forename: Finn Olav
authors.initials: FO
authors.lastname: Levy
mesh_terms: D000818:Animals; D006325:Heart Atria / Q000378:metabolism; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects*; D010727:Phosphoric Diester Hydrolases / Q000502:physiology*; D044422:Receptors, Serotonin, 5-HT4 / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D058828:Serotonin 5-HT4 Receptor Agonists; D013552:Swine
chemical_list: D058828:Serotonin 5-HT4 Receptor Agonists; D044422:Receptors, Serotonin, 5-HT4; D012701:Serotonin; D010727:Phosphoric Diester Hydrolases