Effects of iEW synthetic peptide isomers on bone marrow colony-forming capacity in vivo.
Studies of cooperative effects of D- or L-isomers of iEW dipeptide and neuraminidase on the number of splenic CFU, comparison of the peptide effects on CD34+ cells and splenic CFU, and evaluation of the effects of iEW D- or L-isomers on parameters of T-cell activation showed that interactions of L-(iEW) and D-(iEW) with CD34+ surface receptors are realized through the same mechanism, while their different biological effects on hemopoietic precursor cells in vivo can be explained by their different influence on T-component of the microenvironment.
Semina
O V
OV
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. ovs45@mail.ru
Semenets
T N
TN
Zamulaeva
I A
IA
Selivanova
E I
EI
Malyutina
Ya V
YV
Semin
Yu A
YA
Deigin
V I
VI
Saenko
A S
AS
D000818:Animals; D018952:Antigens, CD34 / Q000032:analysis; D001854:Bone Marrow Cells / Q000187:drug effects*; D017252:CD3 Complex / Q000032:analysis; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D009439:Neuraminidase / Q000494:pharmacology; D013234:Stem Cells / Q000187:drug effects*; D013237:Stereoisomerism
D018952:Antigens, CD34; D017252:CD3 Complex; D004151:Dipeptides; C508783:isoglutamyl-tryptophan; D009439:Neuraminidase