title: [Study of renal morphology and function in children with nocturnal enuresis. Relationship with sensitivity or resistance to desmopressin].
abstract: BACKGROUND
  In the last few years, there have been reports that children with nocturnal enuresis frequently have hypercalciuria. Likewise, children with desmopressin-resistant enuresis have recently been reported to have a higher renal concentration capacity than patients with desmopressin-sensitive enuresis.
  
  
  OBJECTIVE
  To study renal function and urinary calcium excretion and to register familial history of enuresis and urolithiasis in a group of children with enuresis, whether responders or nonresponders to desmopressin, followed-up in our hospital.
  
  
  METHODS
  A cohort of 60 patients (42 boys and 18 girls) who were referred to the hospital because of nocturnal enuresis.
  
  
  RESULTS
  Hypercalciuria was detected in 26 children (43.3 %) and hypocitraturia in eight (13.3 %). The frequency of hypercalciuria was higher in desmopressin-resistant patients than in desmopressin-sensitive patients, but this difference was not statistically significant. Sonographic renal morphological anomalies were detected in 11 children (18.3 %). No differences in renal handling of water were detected when the patients were distributed according to the grade of sensitivity to desmopressin.
  
  
  CONCLUSIONS
  In our cohort we found a high frequency of hypercalciuria in children with nocturnal enuresis. No differences were observed in maximal urinary osmolality among desmopressin-resistant and desmopressin-sensitive children.
authors.affiliation: Unidad de Nefrología Pediátrica, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. joansdt@comb.es
authors.forename: C L
authors.initials: CL
authors.lastname: Marrero Pérez
authors.forename: V
authors.initials: V
authors.lastname: García Nieto
authors.forename: M I
authors.initials: MI
authors.lastname: Luis Yanes
mesh_terms: D050034:Antidiuretic Agents / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D004351:Drug Resistance; D004775:Enuresis / Q000188:drug therapy* / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000502:physiology*; D008297:Male; D014463:Ultrasonography; D014545:Urinary Calculi
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin; D002118:Calcium