title: Metal tissue kinetics in regenerating liver, thymus, spleen, and submandibular gland after partial hepatectomy in mice.
abstract: Liver regeneration after partial hepatectomy (pHx) is a well-defined process, which involves the concerted action of extra- and intracellular factors resulting in induction of cell replication and its inhibition at the time when the entire liver mass is restored. Concomitantly, the breakdown of previously maintained tolerance and the exposure of self-antigens lead to the activation of preimmune and immune repertoires, which participate in surveillance against aberrant cells and the re-establishment of previous morphostasis. Because, in these events, important biological function might have tissue minerals that are affecting the structural integrity and enzyme activities, transduction signals, transcription and replication factors during cell proliferation and apoptosis, as well as the development and maintenance of immune functions and cytokine production, in this study we analyzed tissue dynamics of zinc, iron, magnesium, and calcium in the liver, thymus, spleen, and submandibular gland in intact and pHx mice on the 1st, 2nd, 7th, and 15th d after one-third pHx, using microwave digestion and inductivity coupled plasma spectrometry. The data showed that pHx induces significant and interconnected changes in all of the estimated metals not only in the regenerating liver but also in the lymphatic tissues and submandibular gland, indicating their importance for the control of growth processes.
authors.affiliation: Department of Chemistry and Biochemistry, Medical Faculty of Rijeka, B. Branchetta 22, 51 000 Rijeka, Croatia.
authors.forename: Cedomila
authors.initials: C
authors.lastname: Milin
authors.forename: Marin
authors.initials: M
authors.lastname: Tota
authors.forename: Robert
authors.initials: R
authors.lastname: Domitrovic
authors.forename: Jasminka
authors.initials: J
authors.lastname: Giacometti
authors.forename: Radojka
authors.initials: R
authors.lastname: Pantovic
authors.forename: Mira
authors.initials: M
authors.lastname: Cuk
authors.forename: Ines
authors.initials: I
authors.lastname: Mrakovcic-Sutic
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Jakovac
authors.forename: Biserka
authors.initials: B
authors.lastname: Radosevic-Stasic
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D006498:Hepatectomy; D007501:Iron / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration / Q000502:physiology*; D008274:Magnesium / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000378:metabolism*; D013363:Submandibular Gland / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
chemical_list: D008670:Metals; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium