title: Evaluation of new software for angiographic determination of right ventricular volumes.
abstract: OBJECTIVE
  The scope of the study was to evaluate a recent software for angiographic volume determination as compared to cardiovascular magnetic resonance imaging.
  
  
  BACKGROUND
  A new right ventricular analysis software closes a diagnostic gap in quantitative angiography. Cardiovascular magnetic resonance imaging short axis multi slice summation is a validated reference standard.
  
  
  METHODS
  Right ventricular angiograms were acquired in frontal and lateral projection in 15 pediatric and 17 adult patients. Additional angiograms were acquired in RAO30 degrees /LAO60 degrees projections in 10 adult patients. The tested models comprised area length with different regressions, multi-slice with different regressions, Boak, and pyramid method. Original regressions were used to calculate angiographic right ventricular volume. Right ventricular reference volumes were determined by multi-slice summation from cardiac magnetic resonance short-axis images.
  
  
  RESULTS
  Mean inter-observer difference was -1 ml (95% confidence: -35-34 ml) and mean intra-observer difference was 0 ml (95% confidence: -22-22 ml). There was no significant difference (4 ml, 95% confidence: -22-30 ml) between geometric calibration and calibration by a sphere. The area length and multi-slice models demonstrated the best agreement with the cardiac magnetic resonance reference. Performance was best for the Onnasch Lange models.
  
  
  CONCLUSIONS
  The evaluated software provides acceptably accurate volume estimates for the majority of ventricles. In a few cases larger errors may occur, however. The area length and multi-slice models preferably with Onnasch Lange regressions may be recommended. Inter- and intra-observer agreement were excellent. Geometric calibration using data from DICOM header files may be used.
authors.affiliation: Department of Internal Medicine and Cardiology, German Heart Institute, Augustenburger Platz 1, 13353, Berlin, Germany. ewellnhofer@t-online.de
authors.forename: Ernst
authors.initials: E
authors.lastname: Wellnhofer
authors.forename: Peter
authors.initials: P
authors.lastname: Ewert
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hug
authors.forename: Wei
authors.initials: W
authors.lastname: Hui
authors.forename: Oliver
authors.initials: O
authors.lastname: Kretschmar
authors.forename: Disthapron
authors.initials: D
authors.lastname: Chavengsuk
authors.forename: Titus
authors.initials: T
authors.lastname: Kühne
authors.forename: Hashim
authors.initials: H
authors.lastname: Abdul-Khaliq
authors.forename: Eike
authors.initials: E
authors.lastname: Nagel
authors.forename: Peter E
authors.initials: PE
authors.lastname: Lange
authors.forename: Eckart
authors.initials: E
authors.lastname: Fleck
mesh_terms: D000293:Adolescent; D000328:Adult; D002306:Cardiac Volume; D002648:Child; D002675:Child, Preschool; D017023:Coronary Angiography / Q000379:methods*; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012984:Software; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right