title: Vitiligo with inflammatory raised borders, associated with atopic dermatitis.
abstract: A 31-year-old man had had atopic dermatitis since childhood and developed vitiligo with inflammatory raised borders 5 years prior to presentation. Immunohistochemically, CD4+ T cells infiltrated predominantly in the raised border of vitiligo, while CD8+ T cells were present just outside of the borders, suggesting that CD8+ cells were an antecedent to the CD4+ cells. Despite the presence of atopic dermatitis, the percentage of CXCR3+ CD4+ Th1 cells increased in the patient's peripheral blood, compared with a representative atopic patient showing a high percentage of CCR4+CD4+ Th2 cells. This case suggests that vitiligo with inflammatory raised borders can occur even in patients with atopic dermatitis when Th1 cells are activated and overcome the Th2-dominant state.
authors.affiliation: Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan. k-sugita@med.uoeh-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: K
authors.initials: K
authors.lastname: Izu
authors.forename: Y
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003876:Dermatitis, Atopic / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007866:Leg; D008297:Male; D054398:Receptors, CCR4; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000276:immunology; D014820:Vitiligo / Q000150:complications / Q000276:immunology* / Q000473:pathology
chemical_list: C515354:CCR4 protein, human; C515187:CXCR3 protein, human; D054398:Receptors, CCR4; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine