Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.
In the course of structure-activity relationship studies, diversely substituted 1-(beta-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.
Sassatelli
Mathieu
M
Laboratoire SEESIB, Université Blaise-Pascal, UMR 6504 du CNRS, 24, avenue des Landais, 63177 Aubière, France.
Bouchikhi
Fadoua
F
Messaoudi
Samir
S
Anizon
Fabrice
F
Debiton
Eric
E
Barthomeuf
Chantal
C
Prudhomme
Michelle
M
Moreau
Pascale
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006031:Glycosylation; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007211:Indoles; C057812:indoline