A diversity oriented four-component approach to tetrahydro-beta-carbolines initiated by Sonogashira coupling.
A consecutive four-component synthesis of highly-substituted tetrahydro-beta-carbolines can be achieved by a coupling-aminatio-aza-annulation-Pictet-Spengler (CAAPS) sequence creating five new sigma-bonds and four new stereocenters in a one-pot fashion. The structures were unambiguously supported by X-ray structure analyses.
Karpov
Alexei S
AS
Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.
Rominger
Frank
F
Müller
Thomas J J
TJ
D000586:Amination; D001372:Aza Compounds / Q000737:chemistry; D002243:Carbolines / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D011807:Quinolizines / Q000737:chemistry
D001372:Aza Compounds; D002243:Carbolines; D011807:Quinolizines; D006859:Hydrogen