title: Antioxidants and a new germacrane sesquiteroene from Carissa spinarum.
abstract: A new germacrane derivative, care none (1) was isolated from the stems of a well-known medicinal plant, Carissa spinarum L. together with a new ester, 3'-(4''-methoxyphenyl)-3-oxo-ropionyl hexadecanoate (2). Their structures were established using 1D, 2D NMR spectroscopic and synthetic methods. The chloroform extract of the plant displayed strong antioxidant (DPPH) activity. Several other known compounds were also isolated for the first time from this active extract. The antioxidant activity of major lignans was studied.
authors.affiliation: Natural Products Laboratory, Division of Organic Chemistry-1, Hyderbad-500 007, India.
authors.forename: R Jagdeeshwar
authors.initials: RJ
authors.lastname: Rao
authors.forename: U Sampath
authors.initials: US
authors.lastname: Kumar
authors.forename: S Venkat
authors.initials: SV
authors.lastname: Reddy
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: J Madhusudana
authors.initials: JM
authors.lastname: Rao
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D029062:Apocynaceae / Q000737:chemistry*; D010168:Palmitates / Q000737:chemistry / Q000302:isolation & purification*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C508391:3'-(4''-methoxyphenyl)-3-oxo-ropionyl hexadecanoate; D000975:Antioxidants; D010168:Palmitates; D010936:Plant Extracts; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C508390:carenone