title: Extramammary Paget's disease with bowenoid histologic features accompanied by an ectopic lesion on the upper abdomen.
abstract: We present a 79-year-old man who suffered from extramammary Paget's disease (EMPD) with bowenoid histological features accompanied by an ectopic EMPD lesion on his abdomen. He had had an erythematous plaque on his genital region for three years. Based on a biopsy specimen, he was referred to our hospital with the histological diagnosis of Bowen's disease. The histological findings of the genital lesion obtained by surgical resection showed typical areas of Paget's cells adjacent to areas characteristic of Bowen's disease. Immunohistochemical findings showed CEA and CK7 positive tumor cells in both areas, so the atypical cells showing the bowenoid pattern could be regarded as tumor cells of Paget's disease. Immunohistochemical staining for CEA and CK7 along with multiple biopsies can be helpful in making the diagnosis of Paget's disease with bowenoid histologic features.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, Showamachi, Maebashi, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nagai
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Ishibuchi
authors.forename: Motoi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Matsushima
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000005:Abdomen; D000368:Aged; D001913:Bowen's Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005837:Genitalia, Male / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010145:Paget Disease, Extramammary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery