title: [Intracranial pressure response during secretion aspiration after administration of a muscle relaxant].
abstract: Aspiration of secretions is a usual nursing technique in patients undergoing mechanical ventilation that may be the cause of increased Intracranial Pressure (ICP).
  
  
  OBJECTIVE
  This study aims to evaluate the repercussion of a muscle relaxant on ICP with secretion aspiration.
  
  
  METHODS
  Clinical trial using the same patient as case and control, performing two endotracheal aspirations in each patients, on of them after administration of a muscle relaxant (Cis-Atracurium) and another no. The bolus administration of the relaxant in the first or second aspiration was done randomly. Thirteen patients with intraparenchymatous ICP measurement catheter were studied within the first 36 hours post-placement and with sedoanalgesia for a score of 6 on the Ramsay scale. ICP and CPP were measured before, during and after each aspiration.
  
  
  METHODS
  SPSS 11.0 program was used. Data analysis by Student's t test for paired data. Statistical significance level accepted was 95%.
  
  
  RESULTS
  On comparing the cases in which muscle relaxant was administered with those in which it was not administered, statistically significant differences were found in the ICP and CCP values during secretion aspiration.
  
  
  CONCLUSIONS
  According to the data obtained in the study, a lower increase of ICP was observed during secretion aspiration in those cases in which muscle relaxant was administered prior to the aspiration.
authors.affiliation: DUE, Unidad de Cuidados Intensivos, Hospital de Navarra, Pamplona, Spain. nuchivi@yahoo.es
authors.forename: Nuria
authors.initials: N
authors.lastname: Chivite Fernández
authors.forename: Amparo
authors.initials: A
authors.lastname: Martínez Oroz
authors.forename: Mercedes
authors.initials: M
authors.lastname: Marraco Bonmcompte
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Navarro García
authors.forename: E Salvador
authors.initials: ES
authors.lastname: Nuin
authors.forename: José Luis
authors.initials: JL
authors.lastname: Gómez de Segura Nieva
authors.forename: Begoña
authors.initials: B
authors.lastname: Bermejo Fraile
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001279:Atracurium / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001930:Brain Injuries / Q000150:complications / Q000451:nursing / Q000503:physiopathology; D002404:Catheterization; D003128:Coma / Q000209:etiology / Q000451:nursing / Q000503:physiopathology; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology* / Q000503:physiopathology; D007427:Intracranial Pressure / Q000187:drug effects / Q000502:physiology; D007442:Intubation, Intratracheal / Q000451:nursing; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000494:pharmacology; D013396:Suction / Q000009:adverse effects*
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; C101584:cisatracurium