[The experimental researches on the use of triamcinolone acetonide for the prevention of implant capsular contracture].
OBJECTIVE
To explore the use of triamcinolone acetonide for the prevention of implant capsular contracture.


METHODS
20 rabbits were randomly undivided into 2 groups of 10 animals each. Every 10 ml silicone implant was implanted beneath the panniculus carnosus muscle of one rabbit. At the same time, a modified expander catheter was mounted on the implant. This catheter has many lateral holes and the end was blind. Triamcinolone acetonide (10 mg/3 ml) was infused through the expander pot and catheter as the experimental groups. On the other hand, 3 ml saline was used as the control group at 1, 2, and 3 months. At 6 months, measures related to contracture and capsular histology examinations were performed on anesthetized animals.


RESULTS
Baker scores, capsular incision width and capsular thickness of the saline groups were evidently higher than that of triamcinolone acetonide groups (P < 0.01). Implant compression of the saline groups was evidently lower than that of triamcinolone acetonide group. Histology revealed a thinner capsules and less fibrous tissue deposition around the triamcinolone acetonide group, as compared with saline group.


CONCLUSIONS
It is effective to deliver triamcinolone acetonide to reduction of capsular contracture through the catheter and its pot.
Yang
Wei-Qi
WQ
Department of Burns and Plastic Surgery, the Second People's Hospital, Shenzhen 518035, China.
Yang
Pei-Ying
PY
Fang
Jin-Cai
JC
Luan
Jie
J
Zhang
Xu-Hui
XH
Zhu
Zhi-Xiang
ZX
D000818:Animals; D019928:Breast Implantation / Q000009:adverse effects; D003286:Contracture / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*
D014222:Triamcinolone Acetonide