title: Conversion of taxane glycosides to 10-deacetylbaccatin III.
abstract: 10-Deacetylbaccatin III (10-DAB III) (2) was obtained by a series of treatment of a mixture of taxane glycosides (3, 4, and 5) without isolation before treatment. Since the taxane glycosides are isolated with paclitaxel from yew trees and can be found during the process of the production of paclitaxel, their conversion to 10-DAB III improves the total yield of paclitaxel (1) and docetaxel.
authors.affiliation: Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, School of Life Science, Fudan University, Shanghai 200433, China. jmchen@fudan.edu.cn
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Chen
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000737:chemistry*; D013058:Mass Spectrometry; D015394:Molecular Structure; D043823:Taxoids / Q000138:chemical synthesis / Q000737:chemistry*; D020946:Taxus / Q000737:chemistry*
chemical_list: D006027:Glycosides; D043823:Taxoids; C042213:10-deacetylbaccatine III