Identification of plant microRNA homologs.
MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that regulate gene and protein expression in plants and animals. MiRNAs have so far been identified mostly by specific cloning of small RNA molecules, complemented by computational methods. We present a computational identification approach that is able to identify candidate miRNA homologs in any set of sequences, given a query miRNA. The approach is based on a sequence similarity search step followed by a set of structural filters.
Dezulian
Tobias
T
Center for Bioinformatics Tübingen, Tübingen University, Germany. dezulian@informatik.uni-tuebingen.de
Remmert
Michael
M
Palatnik
Javier F
JF
Weigel
Detlef
D
Huson
Daniel H
DH
D000465:Algorithms; D001483:Base Sequence; D017124:Conserved Sequence; D035683:MicroRNAs / Q000032:analysis / Q000737:chemistry* / Q000235:genetics*; D008969:Molecular Sequence Data; D009862:Online Systems; D010944:Plants / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D014584:User-Computer Interface
D035683:MicroRNAs