title: Iridoid glycosides and grayanane diterpenoids from the roots of Craibiodendron henryi.
abstract: Four new iridoid glycosides, 10-O-trans-p-coumaroylscandoside (1), 10-O-cis-p-coumaroylscandoside (2), 10-O-trans-p-coumaroyldesacetyl asperulosidic acid (3), and 10-O-cis-p-coumaroyldesacetyl asperulosidic acid (4), and two new grayanane diterpenoids, 14beta-O-(2S,3S-nilyl)-2alpha,3beta,5beta,6beta,16alpha-pentahydroxygrayanane (5) and 14beta-O-(2S,3S-nilyl)-2alpha,3beta,5beta,6beta,16alpha-pentahydroxygrayan-10(20)-ene (6), have been isolated from Craibiodendron henryi. The structures of these compounds were determined by chemical and spectroscopic methods including 1H-1H COSY, HMQC, HMBC, and NOESY experiments. Antioxidant activities and vasodilator effects of these compounds were assessed.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
authors.forename: Xiang-zhong
authors.initials: XZ
authors.lastname: Huang
authors.forename: Ying-hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Shi-shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Guang-miao
authors.initials: GM
authors.lastname: Fu
authors.forename: You-cai
authors.initials: YC
authors.lastname: Hu
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Fan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029791:Ericaceae / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D004224:Diterpenes; D039823:Iridoids; D014665:Vasodilator Agents