title: Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis.
abstract: BACKGROUND
  Caveolin-1 is implicated in the oncogenic transformation of cells as a tumor suppressor. In several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL).
  
  
  METHODS
  Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression.
  
  
  RESULTS
  Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression. However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size.
  
  
  CONCLUSIONS
  These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is a marker for predicting prognosis in PCL.
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kyung Chul
authors.initials: KC
authors.lastname: Moon
authors.forename: Geon Kook
authors.initials: GK
authors.lastname: Lee
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Yoo
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Jeon
authors.forename: Jin-Haeng
authors.initials: JH
authors.lastname: Chung
authors.forename: Jungho
authors.initials: J
authors.lastname: Han
authors.forename: Doo Hyun
authors.initials: DH
authors.lastname: Chung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D051242:Caveolin 1 / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D051242:Caveolin 1