title: What is a 'failure' of bisphosphonate therapy for osteoporosis?
abstract: Assessing the effectiveness of bisphosphonate therapy is problematic. Bone mineral density and markers of bone turnover are often used, but the true measure is prevention of new fractures.
authors.affiliation: Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic Foundation, OH 44195, USA. careyj@ccf.org
authors.forename: John J
authors.initials: JJ
authors.lastname: Carey
mesh_terms: D000284:Administration, Oral; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D010349:Patient Compliance; D017211:Treatment Failure
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates