Atelocollagen punctal occlusion in dry eye patients.
OBJECTIVE
To evaluate the efficacy and safety of atelocollagen punctal occlusion for dry eye patients.


METHODS
Prospective noncomparative interventional case series.


METHODS
Atelocollagen was injected into the superior and inferior canaliculi of 52 eyes of 28 dry eye patients. Vital staining of the ocular surface, breakup time of tears (BUT), tear volume, and corneal epithelial permeability to fluorescein were examined before and 1, 2, 4, and 8 weeks after treatment.


RESULTS
Rose bengal stain, fluorescein stain, BUT, and corneal epithelial permeability to fluorescence were significantly improved 1 week after atelocollagen punctal occlusion, and the improvement was maintained for up to 8 weeks after treatment.


CONCLUSIONS
Atelocollagen punctal occlusion effectively improves ocular surface disorders in dry eye patients.
Miyata
Kazunori
K
Meiwakai Medical Foundation, Miyata Eye Hospital, Miyakonojo, Miyazaki, Japan.
Otani
Shinichiro
S
Miyai
Takashi
T
Nejima
Ryohei
R
Amano
Shiro
S
D000328:Adult; D000368:Aged; D003094:Collagen / Q000009:adverse effects / Q000627:therapeutic use*; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000503:physiopathology; D019573:Epithelium, Corneal / Q000378:metabolism; D005143:Eyelids / Q000187:drug effects*; D005260:Female; D019793:Fluorescein / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D015590:Fluorophotometry; D006801:Humans; D007765:Lacrimal Apparatus / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011446:Prospective Studies; D012395:Rose Bengal / Q000493:pharmacokinetics; D013666:Tears / Q000502:physiology; D016896:Treatment Outcome
D005456:Fluorescent Dyes; D009883:Ophthalmic Solutions; C059821:atelocollagen; D012395:Rose Bengal; D003094:Collagen; D019793:Fluorescein