title: Dynein motility: four heads are better than two.
abstract: Cytoplasmic dynein is a microtubule-based motor protein that transports membranes in cells. The movement driven by a single dynein molecule in vitro is not as robust as dynein-driven movements in cells. A new study suggests that transport by multiple dyneins is more similar to cellular motions.
authors.affiliation: Department of Biomedical Engineering, University of Rochester, NY 14450, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: McGrath
mesh_terms: D000072159:Dynactin Complex; D004398:Dyneins / Q000378:metabolism*; D016547:Kinesins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology
chemical_list: D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; D020409:Molecular Motor Proteins; D009218:Myosins; D004398:Dyneins; D016547:Kinesins