title: Molecular evolution of human influenza A/H3N2 virus in Asia and Europe from 2001 to 2003.
abstract: Hemagglutinin sequences of 146 human influenza A/H3N2 strains identified in respiratory specimens from Asia and Europe during the 2001-2003 influenza seasons were analyzed by DNA sequencing. Our results suggest that four amino acid substitutions, L25I, H75Q, H155T, and Q156H, led to the antigenic conversion of the previously predominant A/Panama/2007/99-like strains to the more recent A/Fujian/411/2002-like strains.
authors.affiliation: Applied Immunology and Microbiology Division, Wyeth Vaccines Research, 401 N. Middletown Road, Building 180, Pearl River, NY 10965, USA.
authors.forename: X Sherry
authors.initials: XS
authors.lastname: Chi
authors.forename: Trentice V
authors.initials: TV
authors.lastname: Bolar
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: John S
authors.initials: JS
authors.lastname: Tam
authors.forename: Ruth
authors.initials: R
authors.lastname: Rappaport
authors.forename: Sheau-Mei
authors.initials: SM
authors.lastname: Cheng
mesh_terms: D019943:Amino Acid Substitution; D001208:Asia / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis; D005060:Europe / Q000453:epidemiology; D019143:Evolution, Molecular; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; C483468:hemagglutinin, human influenza A virus