title: [Five cases of locally advanced rectal cancer or local recurrence performed intra-arterial infusion chemotherapy via the internal iliac artery].
abstract: Intra-arterial infusion chemotherapy via the internal iliac artery was performed in 5 patients with locally advanced rectal cancer or recurrent rectal cancer. Arterial infusion chemotherapy was conducted into the internal iliac artery via bilateral femoral artery following a blood flow change with a coil. 5 FU 500 mg and l-leucovorin 125 mg/m2 were injected weekly. An average time of injections or its duration was 40 (17-74) times or 12.8 (5-23) months, respectively. Disappearance or improvement of symptoms was observed in 4 cases. A decrease of tumor size observed by CT was in 2 cases and a decrease of blood CEA level was in 3 cases. As for the complication of arterial infusion chemotherapy, dermatopathy was found in all of the cases, and sensory disturbance of lower extremities was in 3 cases, infection was in 2 cases and catheter obstruction was in 2 cases. A decrease of dosage or abundance of continuation was done during the course due to complications. Two patients with primary cancer died 1-3 years after the treatment, and 2 patients with recurrence died 7 months to 1 year after the treatment. One patient with primary cancer is continuing the treatment for the last 2 years though multiple metastatic diseases have been confirmed.
authors.affiliation: Dept. of Surgery, Fujita Health University School of Medicine.
authors.forename: Yoshikaze
authors.initials: Y
authors.lastname: Koide
authors.forename: Koutaro
authors.initials: K
authors.lastname: Maeda
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Hanai
authors.forename: Harunobu
authors.initials: H
authors.lastname: Sato
authors.forename: Kouji
authors.initials: K
authors.lastname: Masumori
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Aoyama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Katsuno
authors.forename: Masuo
authors.initials: M
authors.lastname: Funabashi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kamano
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Agata
authors.forename: Tomohito
authors.initials: T
authors.lastname: Noro
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007083:Iliac Artery; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012004:Rectal Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D002955:Leucovorin; D005472:Fluorouracil