title: Brain magnetic resonance imaging in tyrosinemia.
abstract: A 3.5-year-old girl with tyrosinemia is reported. A computed tomography scan of the abdomen revealed multiple hepatic nodules. Brain magnetic resonance imaging revealed bilateral high-signal changes confined to the globus pallidus on T2-weighted images. Globus pallidus lesions likely represented neuropathologic changes such as astocytosis, delayed myelination, and status spongiosus (myelin splitting and vacuolation).
authors.affiliation: Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey. rnsener@med.ege.edu.tr
authors.forename: R N
authors.initials: RN
authors.lastname: Sener
mesh_terms: D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000172:deficiency; D001927:Brain Diseases / Q000175:diagnosis*; D002675:Child, Preschool; D003711:Demyelinating Diseases / Q000175:diagnosis; D005260:Female; D005911:Gliosis / Q000175:diagnosis; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009186:Myelin Sheath / Q000473:pathology; D011859:Radiography; D020176:Tyrosinemias / Q000150:complications* / Q000000981:diagnostic imaging
chemical_list: D015111:4-Hydroxyphenylpyruvate Dioxygenase