title: In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach.
authors.affiliation: Department of Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton Laboratories MS 4088, Groton, CT 06340, USA. r.scorr.orbach@pfizer.com
authors.forename: R Scott
authors.initials: RS
authors.lastname: Obach
authors.forename: Robert L
authors.initials: RL
authors.lastname: Walsky
authors.forename: Karthik
authors.initials: K
authors.lastname: Venkatakrishnan
authors.forename: J Brian
authors.initials: JB
authors.lastname: Houston
authors.forename: Larry M
authors.initials: LM
authors.lastname: Tremaine
mesh_terms: D000465:Algorithms; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003627:Data Interpretation, Statistical; D004347:Drug Interactions; D006801:Humans; D008657:Metabolic Clearance Rate; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D036301:Qualitative Research
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System