title: [Association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan].
abstract: OBJECTIVE
  To investigate the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan.
  
  
  METHODS
  Polymerase chain reaction with sequence-specific primers (PCR-SSP) genotyping method was conducted in 58 ethnic Yi patients with type 2 diabetes mellitus and 82 ethnically matched controls from Chuxiong of Yunnan. Then a study was made on the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes mellitus.
  
  
  RESULTS
  The frequency of HLA-DQA1*0301 allele in the patients with type 2 diabetes mellitus was significantly higher than that in the healthy controls (P=0.002, RR=3.097), and the frequency of HLA-DQA1*0601 in the patients was significantly lower (P=0.025, RR=0.429).
  
  
  CONCLUSIONS
  In Yi nationality of Yunnan, HLA-DQA1*0301 allele may be a susceptible gene and the HLA-DQA1*0601 allele may protect individuals from the risk of diabetes mellitus.
authors.affiliation: The Clinical Laboratory, the Second Affiliated Hospital, Kunming Medical College, Kunming, Yunnan, P. R. China. yy8657@Peoplemail.com.cn
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Yang
authors.forename: Chun-feng
authors.initials: CF
authors.lastname: Ren
authors.forename: Li
authors.initials: L
authors.lastname: Xue
authors.forename: Hui-yun
authors.initials: HY
authors.lastname: Yuan
authors.forename: Mian
authors.initials: M
authors.lastname: Xu
authors.forename: Wen-lin
authors.initials: WL
authors.lastname: Tai
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Du
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen