title: Elevated levels of inflammatory biomarkers in the cerebrospinal fluid after coronary artery bypass surgery are predictors of cognitive decline.
abstract: Recovery from cardiac surgery is marred for many patients by the development of neurological, psychological or cognitive dysfunction. An uncontrolled inflammatory reaction, in response to surgical stress, may be responsible. To confirm this hypothesis, the present study evaluated changes in the levels of cytokines in cerebrospinal fluid after coronary artery bypass grafting. One week post-operatively, the concentration of the pro-inflammatory cytokine interleukin-6 markedly increased; 6 months after surgery, however, its level normalized with an increased concentration of the anti-inflammatory interleukin-4. This suggests that a regulated immune response may participate in developing adverse neurologic events and complications following cardiac interventions, and cytokines in the cerebrospinal fluid may serve as specific biomarkers and predictors of developing cognitive decline after coronary surgery.
authors.affiliation: Department of Psychiatry, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Kálmán
authors.forename: Anna
authors.initials: A
authors.lastname: Juhász
authors.forename: Gábor
authors.initials: G
authors.lastname: Bogáts
authors.forename: Barna
authors.initials: B
authors.lastname: Babik
authors.forename: Agnes
authors.initials: A
authors.lastname: Rimanóczy
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Janka
authors.forename: Botond
authors.initials: B
authors.lastname: Penke
authors.forename: András
authors.initials: A
authors.lastname: Palotás
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid*; D001026:Coronary Artery Bypass; D006801:Humans; D018836:Inflammation Mediators / Q000134:cerebrospinal fluid*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators