Frontiers in viral diagnostics.
Dilated cardiomyopathy (DCM) is a fatal myocardial disease with an incidence of 40:100,000. In recent years, viral infection as a causative agent for myocarditis followed by DCM has become a main topic of research. On the one hand, the virus violates the myocardial integrity itself; on the other hand, the virus induces inadequate local humoral and cellular defense reaction resulting in cardiomyocyte death, fibrosis, and overall cardiac dysfunction. Classical virological approaches are no longer sufficient to detect and identify the virus in the heart. The possibility of endomyocardial biopsies, as well as the further development of new high-specific and sensitive molecular approaches including real-time PCR or sequencing, allows us to detect and to identify the patient- specific causal virus and to predict the progression of disease and hopefully, in the future, to develop virus-specific treatment strategies.
Pauschinger
M
M
Department of Cardiology and Pneumology, Charité University Medicine Berlin, Germany. matthias.pauschinger@charite.de
Kallwellis-Opara
A
A
D002311:Cardiomyopathy, Dilated / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D006321:Heart / Q000821:virology; D006801:Humans; D025202:Molecular Diagnostic Techniques; D009205:Myocarditis / Q000276:immunology / Q000473:pathology / Q000821:virology*; D009206:Myocardium / Q000473:pathology; D012703:Serotyping; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*
D004279:DNA, Viral