title: Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.
abstract: Two new hirsutane sesquiterpenes, connatusins A (1) and B (2), were isolated from the fungus Lentinus connatus BCC 8996. The structures, closely related to hypnophilin, were elucidated on the basis of the spectroscopic data. An X-ray analysis was performed to confirm the structure of 1. Six known compounds were also obtained. Panepoxydone (5), panepoxydione (6), and dihydrohypnophilin (8) exhibited significant antimalarial and cytotoxic activities.
authors.affiliation: Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. vatcharin.r@psu.ac.th
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.forename: Chittreeya
authors.initials: C
authors.lastname: Tansakul
authors.forename: Saowanit
authors.initials: S
authors.lastname: Saithong
authors.forename: Chaveng
authors.initials: C
authors.lastname: Pakawatchai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Rapheephat
authors.initials: R
authors.lastname: Suvannakad
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D020074:Lentinula / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C506499:connatusin A; C506500:connatusin B