Regulatory T cells and IL-10 in allergic inflammation.
Recent studies suggest that human regulatory T (T reg) cells protect against the development of allergic and asthmatic disease and that their function is impaired during active disease. Two new studies contribute to our understanding of the role that T reg cells play in the control of allergic airway disease in mice. However, these studies also highlight several outstanding questions in the field.
Hawrylowicz
Catherine M
CM
Medical Research Council and Asthma UK Centre for Allergic Mechanisms in Asthma, King's College London, London SE1 9RT, UK. C.M.H.catherine.hawrylowicz@kcl.ac.uk
D000818:Animals; D001249:Asthma / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*