title: Olanzapine versus propranolol in essential tremor.
abstract: OBJECTIVE
  In this study, we evaluated the anti-tremor effect of olanzapine in patients with essential tremor (ET).
  
  
  METHODS
  Thirty-eight patients with ET affecting upper limbs underwent a randomized, crossover study with olanzapine (20 mg/day) and propranolol (120 mg/day). Evaluation (baseline and 1 month after each drug) was done by using the tremor clinical rating scale and a self-reported disability scale.
  
  
  RESULTS
  We did not find statistical difference in all tremor parameters before treatment in two groups. Both drugs improved essential tremor parameters. However, olanzapine significantly improved all tremor parameters except hygiene as compared to propronalol.
  
  
  CONCLUSIONS
  These results suggest that olanzapine might be efficacious for essential tremor. Further clinical trials are indicated to establish the efficacy of olanzapine in patients with ET.
authors.affiliation: Department of Neurology, Atatürk Training and Research Hospital Izmir, Alsancak, Izmir, Turkey. yetimalar@hotmail.com
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Yetimalar
authors.forename: Gülümser
authors.initials: G
authors.lastname: Irtman
authors.forename: Tülay
authors.initials: T
authors.lastname: Kurt
authors.forename: Mustafa
authors.initials: M
authors.lastname: Başoğlu
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001569:Benzodiazepines / Q000627:therapeutic use; D018592:Cross-Over Studies; D004311:Double-Blind Method; D020329:Essential Tremor / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D011433:Propranolol / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D001569:Benzodiazepines; D000077152:Olanzapine; D011433:Propranolol; D017367:Selective Serotonin Reuptake Inhibitors