title: Recent developments in the assessment of efficacy in clinical trials of diabetic neuropathy.
abstract: A large number of measures may be employed in clinical practice and for epidemiologic studies to quantify and risk stratify diabetic patients with neuropathy. However, not all measures are suitable for assessing the benefits of therapeutic intervention. Therefore, for the purpose of this review we focus on measures that may be employed to define the efficacy of interventions in clinical trials of human diabetic neuropathy. Two major types of end points are used: 1) those that assess symptoms for defining efficacy in painful diabetic neuropathy, and 2) those that assess neurologic deficits that assess the effects of treatments that may prevent further degeneration or promote repair.
authors.affiliation: Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
authors.forename: Moaz
authors.initials: M
authors.lastname: Mojaddidi
authors.forename: Cristian
authors.initials: C
authors.lastname: Quattrini
authors.forename: Mitra
authors.initials: M
authors.lastname: Tavakoli
authors.forename: Rayaz A
authors.initials: RA
authors.lastname: Malik
mesh_terms: D002986:Clinical Trials as Topic / Q000639:trends*; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D017063:Outcome Assessment, Health Care