Successful treatment of primary granulocytic sarcoma by non-myeloablative stem cell transplant.
Pre-leukemic granulocytic sarcoma (GS) may pose an initial diagnostic problem and its therapeutic approach has never been formally established. To our knowledge, non-myeloablative stem cell transplantation has been reported in cases of leukemic GS, but not in primary GS. We report a case of primary GS with extensive and aggressive presenting features and successfully treated with intensive chemotherapy followed by non-myeloablative allogeneic stem cell transplant. This resulted in complete remission with minimal complications. Our case demonstrates the potential of graft-vs.-tumour effect in the treatment of GS and suggests that non-myeloablative allogeneic stem cell transplant may be a feasible therapeutic approach for primary GS.
Tan
D
D
Department of Hematology, Singapore General Hospital, Singapore. daryl.tan@singhealth.com.sg
Wong
G C
GC
Koh
L P
LP
Hwang
W
W
Loh
Y
Y
Linn
Y C
YC
Goh
Y T
YT
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D012074:Remission Induction; D023981:Sarcoma, Myeloid / Q000188:drug therapy / Q000628:therapy*; D012680:Sensitivity and Specificity; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome