Serum levels of soluble syndecan-1 in Hodgkin's lymphoma.
BACKGROUND
Syndecan-1 (CD138) is expressed by the Hodgkin-Reed-Sternberg (HRS) cells of classic Hodgkin's lymphoma (cHL), but not in nodular lymphocyte-predominant HL. Syndecan-1 may be involved in the interaction between HRS cells and the cellular and stromal microenvironment typical of nodular sclerosing HL.


METHODS
Serum levels of soluble syndecan-1 were determined by ELISA in 66 patients with HL and 14 age- and sex-matched healthy individuals.


RESULTS
The levels of syndecan-1 were higher in HL patients than controls (100.2 +/- 35.9 ng/ml vs. 67.9 +/- 24.5 ng/ml, p < 0.001). They marginally correlated with advanced age (p = 0.06), male gender (p = 0.07) and consequently high IPS (p = 0.01), but did not correlate with markers of tumor burden and prognosis, including serum interleukin-10 and soluble CD30. At 6 years, failure-free survival was 70 +/- 9% vs. 50 +/- 11% (p = 0.32) for patients with serum soluble syndecan-1 levels above or below the observed median value of 91 ng/ml.


CONCLUSIONS
The serum levels of syndecan-1 were elevated in patients with HL, but were not strongly correlated with other potential prognostic factors. Their effect on prognosis deserves further evaluation.
Vassilakopoulos
Theodoros P
TP
First Department of Internal Medicine and Department of Haematology, National and Kapodistrian University of Athens, Laikon University Hospital, Athens, Greece.
Kyrtsonis
Marie-Christine
MC
Papadogiannis
Argiroula
A
Nadali
Gianpaolo
G
Angelopoulou
Maria K
MK
Tzenou
Tatiana
T
Dimopoulou
Maria N
MN
Siakantaris
Marina P
MP
Kontopidou
Flora N
FN
Kalpadakis
Christina
C
Kokoris
Styliani I
SI
Dimitriadou
Evangelia M
EM
Tsaftaridis
Panayiotis
P
Pizzolo
Giovanni
G
Pangalis
Gerassimos A
GA
D000293:Adolescent; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000473:pathology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D011509:Proteoglycans / Q000097:blood*; D053668:Syndecan-1; D053667:Syndecans
D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans