Influence of simulated human pharmacokinetics on the efficacy of temocillin against a Klebsiella pneumoniae meningitis infection in the rabbit.
Woodnutt
G
G
Beecham Pharmaceuticals Research Division, Chemotherapeutic Research Centre, Brockham Park, Betchworth, Surrey, RH3 7AJ, England.
Catherall
E J
EJ
Kernutt
I
I
Mizen
L
L
D000818:Animals; D004195:Disease Models, Animal; D006207:Half-Life; D006801:Humans; D007710:Klebsiella Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy; D007711:Klebsiella pneumoniae; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D010406:Penicillins / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D011817:Rabbits
D010406:Penicillins; C031367:temocillin