Neonatal handling reduces angiotensin II receptor density in the medial preoptic area and paraventricular nucleus but not in arcuate nucleus and locus coeruleus of female rats.
Neonatal handling alters the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-gonads axis (HPG) in adult animals, and angiotensin II (Ang II) modulates the functions in these axes. We tested whether neonatal handling could change the density of Ang II receptors in some central areas in female rats. Results showed decreased density of the Ang II receptors in the medial preoptic area (MPOA) and hypothalamic paraventricular nucleus (PVN) of the neonatal handled group.
Gomes
Cármen Marilei
CM
Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Rua Sarmento Leite 500, Porto Alegre, RS 90050-170, Brazil.
Donadio
Márcio Vinícius Fagundes
MV
Franskoviaki
Inélia
I
Anselmo-Franci
Janete A
JA
Franci
Celso Rodrigues
CR
Lucion
Aldo Bolten
AB
Sanvitto
Gilberto Luiz
GL
D000818:Animals; D000831:Animals, Newborn; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D005260:Female; D006234:Handling, Psychological; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008125:Locus Coeruleus / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011945:Receptors, Angiotensin / Q000502:physiology*
D011945:Receptors, Angiotensin