New ways in which GLP-1 can regulate glucose homeostasis.
Glucagon-like peptide-1 (GLP-1) has a diverse set of peripheral actions which all serve to promote enhanced glucose tolerance, and for this reason it has become the basis for new treatments for type 2 diabetes. In this issue of the JCI, Knauf et al. provide clear evidence that GLP-1 signaling in the CNS is also linked to the control of peripheral glucose homeostasis by inhibiting non-insulin-mediated glucose uptake by muscle and increasing insulin secretion from the pancreas. The authors' work points to an important need to integrate diverse GLP-1 signaling actions and peripheral GLP-1 function in order to better understand both normal and abnormal glucose homeostasis.
D'Alessio
David A
DA
Department of Medicine, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA.
Sandoval
Darleen A
DA
Seeley
Randy J
RJ
D000818:Animals; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008954:Models, Biological; D010446:Peptide Fragments / Q000737:chemistry; D052336:Proglucagon / Q000378:metabolism
D007328:Insulin; D010446:Peptide Fragments; D052336:Proglucagon; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D005947:Glucose