title: Application of sequential injection analysis to pharmaceutical analysis.
abstract: Sequential injection analysis is a well established tool for automation of pharmaceutical analysis. A short historical background of this technique is given as well as a brief discussion on the basic principles and potentials. The current applications of SIA in the pharmaceutical analysis are also described and discussed. The manifolds developed offer good analytical characteristics and are suitable for analysis of drug formulations, process analysis, drug-dissolution, drug-release testing and functional assays for screening potential drugs. The results obtained are in good agreement with those furnished by the application of the reference methods presented in the pharmacopoeias.
authors.affiliation: REQUIMTE, Departamento de Química Física, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4099-030 Porto, Portugal.
authors.forename: A M
authors.initials: AM
authors.lastname: Pimenta
authors.forename: M C B S M
authors.initials: MC
authors.lastname: Montenegro
authors.forename: A N
authors.initials: AN
authors.lastname: Araújo
authors.forename: J Martínez
authors.initials: JM
authors.lastname: Calatayud
mesh_terms: D001682:Biological Availability; D002138:Calibration; D002626:Chemistry, Pharmaceutical; D004345:Drug Industry; D004563:Electrochemistry; D019999:Pharmaceutical Solutions; D010602:Pharmacopoeias as Topic; D012995:Solubility; D013050:Spectrometry, Fluorescence / Q000379:methods; D013053:Spectrophotometry / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D019999:Pharmaceutical Solutions