title: Preparation and evaluation of sustained ophthalmic gel of enoxacin.
abstract: The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of a gel system. The present work describes the formulation and evaluation of an ophthalmic delivery system containing an antibacterial agent, enoxacin, based on the concept of ophthalmic sustained gel, in which 2-hydroxypropyl-beta-cyclo-dextrin (HP-beta-CD) was used as a penetration enhancer in combination with hydroxypropylmethylcellulose (Methocel F4M) which acted as a vehicle. The developed formulation was therapeutically efficacious, nonirritant, and provided sustained release of the drug over 8 h period in vitro and 7 h period in vivo. The developed system is a viable alternative to conventional eye drops.
authors.affiliation: Department of Pharmaceutical, Shenyang Pharmaceutical University, Shenyang, P.R. China.
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Liu
authors.forename: Weisan
authors.initials: W
authors.lastname: Pan
authors.forename: Shufang
authors.initials: S
authors.lastname: Nie
authors.forename: Libo
authors.initials: L
authors.lastname: Zhang
authors.forename: Xinggang
authors.initials: X
authors.lastname: Yang
authors.forename: Jiawei
authors.initials: J
authors.lastname: Li
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000465:Algorithms; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D001082:Aqueous Humor; D019540:Area Under Curve; D002626:Chemistry, Pharmaceutical; D003315:Cornea / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D015365:Enoxacin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D005079:Excipients; D005123:Eye / Q000378:metabolism; D065347:Hypromellose Derivatives; D066298:In Vitro Techniques; D007509:Irritants; D016014:Linear Models; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D017551:Microdialysis; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D007509:Irritants; D014677:Pharmaceutical Vehicles; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D015365:Enoxacin; D065347:Hypromellose Derivatives; D008747:Methylcellulose