title: Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles.
abstract: The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18-fold more potent than BHT (IC50 2.3 x 10(-4) M) with 1.3 x 10(-5) M and 1.2 x 10(-5) M IC50 values, respectively, by interaction of the stable DPPH free radical.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandoğan, Ankara, Turkey. kilcigil@pharmacy.ankara.edu.tr
authors.forename: Gülgün
authors.initials: G
authors.lastname: Ayhan-Kilcigil
authors.forename: Canan
authors.initials: C
authors.lastname: Kuş
authors.forename: Tülay
authors.initials: T
authors.lastname: Coban
authors.forename: Benay
authors.initials: B
authors.lastname: Can-Eke
authors.forename: Süheyla
authors.initials: S
authors.lastname: Ozbey
authors.forename: Mümtaz
authors.initials: M
authors.lastname: Iscan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D016166:Free Radical Scavengers