title: Preoperative cerebral ischemic lesions predict physical health status after on-pump coronary artery bypass surgery.
abstract: BACKGROUND
  Risk assessment is integral to patient selection and counseling before coronary artery revascularization. We studied the predictive ability of cerebral magnetic resonance imaging of preoperative and postoperative cerebral ischemic injury on self-reported physical and mental health at 3 months after coronary artery bypass surgery with or without use of cardiopulmonary bypass.
  
  
  METHODS
  In a prospective clinical trial comparing on-pump and off-pump surgery, 120 patients responded to a questionnaire for self-report of angina (Canadian Cardiovascular Society scale) and physical and mental health status (Short Form 36) at baseline before preoperative cerebral magnetic resonance imaging. Preoperative sets of both magnetic resonance imaging and self-assessments were available for 103 (85.8%) patients. These patients were grouped according to classification of preoperative cerebral magnetic resonance imaging findings. Analysis of covariance determined the association of (1) preoperative magnetic resonance imaging status, (2) new postoperative cerebral lesions, and (3) actual use of cardiopulmonary bypass to physical and mental health.
  
  
  RESULTS
  At 3 months after surgical intervention, 98 of 103 patients completed follow-up. The analysis revealed an interaction effect of preoperative cerebral ischemic injury and use of cardiopulmonary bypass on physical health (F = 9.07, P = .003) independent of age. No independent effects on health status were found of baseline magnetic resonance imaging or new cerebral lesions at 3 months.
  
  
  CONCLUSIONS
  This study strongly suggests that the combination of preoperative cerebral ischemic injury and use of cardiopulmonary bypass can predict postoperative health status at 3 months. Cerebral magnetic resonance imaging might be a more specific indicator than age for preoperative assessment of vulnerability or resilience during rehabilitation after on-pump cardiac surgery.
authors.affiliation: University of Oslo, Faculty Division Rikshospitalet/The Interventional Centre, Oslo, Norway. lars.mathisen@medisin.uio.no
authors.forename: Lars
authors.initials: L
authors.lastname: Mathisen
authors.forename: Marit Helen
authors.initials: MH
authors.lastname: Andersen
authors.forename: Per Kristian
authors.initials: PK
authors.lastname: Hol
authors.forename: Bjørn
authors.initials: B
authors.lastname: Tennøe
authors.forename: Christian
authors.initials: C
authors.lastname: Lund
authors.forename: David
authors.initials: D
authors.lastname: Russell
authors.forename: Runar
authors.initials: R
authors.lastname: Lundblad
authors.forename: Steinar
authors.initials: S
authors.lastname: Halvorsen
authors.forename: Astrid Klopstad
authors.initials: AK
authors.lastname: Wahl
authors.forename: Berit Rokne
authors.initials: BR
authors.lastname: Hanestad
authors.forename: Erik
authors.initials: E
authors.lastname: Fosse
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000009:adverse effects; D005260:Female; D006304:Health Status; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors