title: Role of respiratory epithelium in the development of hyperreactivity of bronchial smooth muscles.
abstract: In guinea pigs sensitized with ovalbumin the respiratory epithelium lost its ability to modulate the responses of airway smooth muscles to histaminergic stimuli. Incubation of bronchial segments with IL-5 potentiated the contractile responses of bronchial smooth muscles to histamine in both intact and sensitized animals. Incubation of bronchial segments with IL-5 receptors moderated contractile activity of segments from sensitized pigs, but not in the segments from intact controls.
authors.affiliation: Siberian State Medical University, Tomsk. kapil@yandex.ru
authors.forename: L V
authors.initials: LV
authors.lastname: Kapilevich
authors.forename: E Yu
authors.initials: EY
authors.lastname: D'yakova
authors.forename: L M
authors.initials: LM
authors.lastname: Ogorodova
authors.forename: T N
authors.initials: TN
authors.lastname: Zaitseva
authors.forename: A E
authors.initials: AE
authors.lastname: Sazonov
authors.forename: A V
authors.initials: AV
authors.lastname: Nosarev
mesh_terms: D000818:Animals; D001980:Bronchi / Q000502:physiology*; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000503:physiopathology*; D004357:Drug Synergism; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D015848:Interleukin-5 / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology*; D010047:Ovalbumin / Q000276:immunology; D020545:Respiratory Mucosa / Q000502:physiology*
chemical_list: D015848:Interleukin-5; D006632:Histamine; D010047:Ovalbumin