Facile and efficient postsynthetic tritium labeling method catalyzed by Pd/C in HTO.
[reaction: see text] We have developed a facile and efficient tritium labeling method using a Pd/C-HTO-H2 system. This method can provide multitritium-labeled compounds in highly diluted HTO under T2 gas-free conditions, and is environmentally benign since purification by silica gel column chromatography is not necessary, which causes a large quantity of radioactive waste such as silica gel and eluent.
Maegawa
Tomohiro
T
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu, 502-8585, Japan.
Hirota
Kosaku
K
Tatematsu
Kenjiro
K
Mori
Yukio
Y
Sajiki
Hironao
H
D002384:Catalysis; D007553:Isotope Labeling / Q000379:methods*; D010165:Palladium; D014316:Tritium / Q000737:chemistry*
D014316:Tritium; D010165:Palladium