title: An essential connection: link between Hsp70's domains at last.
abstract: Communication between the ATPase and substrate binding domains of Hsp70 is critical for regulated interaction between this molecular chaperone and its client proteins. In this issue of Molecular Cell, Jiang et al. (2005) report the structure of an intact Hsp70, revealing critical interactions between the two domains.
authors.affiliation: Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, Madison, Wisconsin 53726, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: D'Silva
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Marszalek
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Craig
mesh_terms: D000818:Animals; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D017434:Protein Structure, Tertiary
chemical_list: D018840:HSP70 Heat-Shock Proteins