title: Multiple adult xanthogranuloma: case report and literature review.
abstract: BACKGROUND
  Non-Langerhans cell histiocytoses form a heterogeneous group defined by the proliferation of cells with macrophage characteristics. Diagnosis is easy in typical cases but becomes more complex in unusual forms.
  
  
  METHODS
  We report the case of a 53-year-old patient who presented multiple brown-to-yellowish papules and nodules of the trunk, neck, and head evolving for 6 months. No visceral involvement was found. Histopathological examination revealed histiocytic proliferation with features of secondary xanthomization with the presence of giant foamy multinucleated Touton cells. One year later, all lesions cleared spontaneously. Based on the clinical presentation and evolution and on the immunohistologic data, we retain the diagnosis of adult xanthogranuloma (AXG) in a diffuse shape.
  
  
  CONCLUSIONS
  Multiple AXG is a rare entity (15 cases reported since 1963) with a stereotypic presentation. It is important to recognize because of its good prognosis and the absence of visceral involvement therefore requiring no investigations or aggressive treatments. This case is interesting because of the complete and spontaneous healing of all the lesions within 20 months.
authors.affiliation: Service de Dermatologie, Hôpital de l'Hôtel Dieu, Lyon, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Saad
authors.forename: François
authors.initials: F
authors.lastname: Skowron
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dalle
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Forestier
authors.forename: Brigitte
authors.initials: B
authors.lastname: Balme
authors.forename: Luc
authors.initials: L
authors.lastname: Thomas
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D005176:Factor XIII / Q000032:analysis; D006099:Granuloma / Q000378:metabolism / Q000473:pathology*; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D014973:Xanthomatosis / Q000378:metabolism / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005176:Factor XIII; C067980:CD68 antigen, human; D000097382:CD68 Molecule