Long-term effects of lanthanum intake on the neurobehavioral development of the rat.
The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameters and neurobehaviors were assessed, including body weight gain, pinna detachment, eye opening, surface righting reflex and swimming endurance. At 30 days of age, DNA concentration and protein/DNA ratio of the whole brain were determined. At 150 days of age, the Morris water maze test was carried out to study the memory and learning abilities of the rats. Differences were found in the body weight gain, surface righting reflex and swimming endurance. Moreover, lanthanum exposure significantly altered the DNA concentration and Protein/DNA in brain. The Morris water maze test showed that lanthanum exposure at 40 mg/kg significantly impaired memory and learning abilities. These findings indicate that lanthanum is a potential behavior teratogen. The information provided by this work should be considered in future applications of lanthanides.
Feng
Liuxing
L
Key Laboratory of Nuclear Analytical Techniques, and Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Xiao
Haiqing
H
He
Xiao
X
Li
Zijie
Z
Li
Fuliang
F
Liu
Nianqing
N
Chai
Zhifang
Z
Zhao
Yuliang
Y
Zhang
Zhiyong
Z
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000503:physiopathology*; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007811:Lanthanum / Q000633:toxicity*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009068:Movement / Q000187:drug effects / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects / Q000502:physiology
D009419:Nerve Tissue Proteins; D007811:Lanthanum; D004247:DNA