Periadolescent morphine exposure alters subsequent behavioral sensitivity to morphine in adult rats.
Little research has been conducted investigating the long-term impact of opioid exposure during adolescence. These experiments were conducted to determine the behavioral effects of morphine exposure during periadolescence (postnatal days 30-32) versus young adulthood (postnatal days 65-67) on subsequent sensitivity to morphine. Male Sprague-Dawley rats were treated with three days of saline (S-S-S), one day of 10 mg/kg morphine followed by two days of saline (M-S-S), or three days of morphine (M-M-M). Unlike adult-treated counterparts, periadolescent M-M-M-treated rats showed greater locomotor response to morphine compared to S-S-S or M-S-S cohorts five weeks after treatment, suggesting age- and exposure-dependent differences in opioid sensitivity.
White
David A
DA
Emory University School of Medicine, Department of Pharmacology, O.W. Rollins Research Building, 1510 Clifton Road, NE, Atlanta, GA 30322, USA. dwhite4@emory.edu
Holtzman
Stephen G
SG
D000367:Age Factors; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000701:Analgesics, Opioid; D009020:Morphine