[Effect of neurotensin on the behavior of rats with damaged serotoninergic neurons under immobilization stress].
It was shown that the immobilization of animals has led to reducing of vertical and horizontal locomotor activity in the "open field" and decreasing of number of conditioned food-procuring reactions into T-maze. The damages of serotoninergic neurons produced via local injections of selective neurotoxin 5, 7-dihydroxytriptamine into dorsal raphe nucleus intensified behavior alterations. Neurotensin administrations reduced effects of neurotoxin: the rats locomotor activity and quantity of conditioned reactions into T-maze were kept at the phone level just after immobilization as well as next two days. The results indicate the important protective significance of neurotensinergic brain structures for ensuring of adaptive behavior of animals with damaged serotoninergic neurons under emotional stress conditions. It is supposed that neurotensin normalizing influences on behavior is connected to a restoration of balance of dopamine-and serotoninergic brain structures interaction.
Shugalev
N P
NP
Stavrovskaia
A V
AV
Iamshchikova
N G
NG
D015116:5,7-Dihydroxytryptamine; D000818:Animals; D007103:Immobilization; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009496:Neurotensin / Q000494:pharmacology / Q000502:physiology*; D011903:Raphe Nuclei / Q000187:drug effects / Q000473:pathology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology*
D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D009496:Neurotensin