[The effect of muscovite on the quality of gastric ulcer healing].
OBJECTIVE
To explore the effect of muscovite on the quality of gastric ulcer healing.


METHODS
Gastric ulcers were produced in male rats by serosal application of acetic acid. Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction. Then the tissue and blood samples were obtained and measured.


RESULTS
In the muscovite group, restored mucosa thickness increased, cystically dilated glands decreased, microvessels in connective tissue increased, the secretion of mucus, hexosamine, PGE2, EGF, bFGF were enhanced, and the express of EGFR was stronger.


CONCLUSIONS
Muscovite can promote the gastric ulcer healing and improve the quality of gastric ulcer healing.
Si
Jian-Min
JM
Institute of Clinic Medicine Research of Sir Run Run Shaw, Zhejiang University, Hangzhou 310016, China. sijm@163.net
Qian
Yun
Y
Wu
Jia-Guo
JG
D000538:Aluminum Silicates / Q000494:pharmacology*; D000818:Animals; D015232:Dinoprostone / Q000097:blood; D066246:ErbB Receptors / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology / Q000503:physiopathology; D006595:Hexosamines / Q000378:metabolism; D008297:Male; D008419:Materia Medica / Q000494:pharmacology*; D009093:Mucus / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology
D000538:Aluminum Silicates; D006595:Hexosamines; D008419:Materia Medica; D016222:Fibroblast Growth Factor 2; D066246:ErbB Receptors; D015232:Dinoprostone