NKG2 receptor-mediated regulation of effector CTL functions in the human tissue microenvironment.
NKG2 receptors and their ligands play an essential role in the control of CTL activation in the tissue microenvironment. We discuss the regulation of NKG2 receptor expression by CTL and how uncontrolled activation of NKG2 receptors can lead to organ-specific autoimmune and inflammatory disorders.
Jabri
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Department of Pathology, University of Chicago, 5841 South Maryland Avenue-S354, Chicago, IL 60637, USA. bjabri@bsd.uchicago.edu
Meresse
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D015551:Autoimmunity; D006801:Humans; D066298:In Vitro Techniques; D019409:Interleukin-15 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology; D008024:Ligands; D018448:Models, Immunological; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*; D055607:Receptors, Natural Killer Cell; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014018:Tissue Distribution
D019409:Interleukin-15; C527054:KLRC1 protein, human; C497869:KLRD1 protein, human; D008024:Ligands; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell