Detection of new diagnostic markers in pathology by focus on growth-regulatory endogenous lectins. The case study of galectin-7 in squamous epithelia.
Lectins represent one of pivotal regulators of the cell proliferation The potential of galectin-7 as a new prognostic marker was studied in normal and transformed squamous epithelia of both ectodermal (epidermis, cornea vs. trichoepithelioma, basal and squamous cell carcinoma) and endodermal (vocal fold epithelium vs. carcinoma) origin. Studies on the cultured cells were also performed. Expression of galectin-7 seems to be connected to the process of stratification, no matter of origin of epithelium. Its expression is significantly reduced in malignant cells, thus galectin-7 might be a differentiation marker of epithelial malignancies.
Chovanec
M
M
Institute of Anatomy of the First Faculty of Medicine, Charles University in Prague, Czech Republic.
Smetana
K
K
Plzák
J
J
Betka
J
J
Plzáková
Z
Z
Stork
J
J
Hrdlicková
E
E
Kuwabara
I
I
Dvoránková
B
B
Liu
F T
FT
Kaltner
H
H
André
S
S
Gabius
H J
HJ
D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis*; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D004848:Epithelium / Q000737:chemistry*; D037161:Galectins / Q000032:analysis* / Q000502:physiology; D006801:Humans; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D037161:Galectins; C092525:LGALS7 protein, human