title: Internal-sensing machinery directs the activity of the regulatory network in Escherichia coli.
abstract: Individual cells need to discern and synchronize transcriptional responses according to variations in external and internal conditions. Metabolites and chemical compounds are sensed by transcription factors (TFs), which direct the corresponding specific transcriptional responses. We propose a classification of the currently known TFs of Escherichia coli based on whether they respond to metabolites incorporated from the exterior, to internally produced compounds, or to both. When analyzing the mutual interactions of TFs, the dominant role of internal signal sensing becomes apparent, greatly due to the role of global regulators of transcription. This work encompasses metabolite-TF interactions, bridging the gap between the metabolic and regulatory networks, thus advancing towards an integrated network model for the understanding of cellular behavior.
authors.affiliation: Programa de Genómica Computacional, Centro de Ciencias Genómicas, UNAM, Cuernavaca, Morelos 62100, México. agustino@ccg.unam.mx
authors.forename: Agustino
authors.initials: A
authors.lastname: Martínez-Antonio
authors.forename: Sarath Chandra
authors.initials: SC
authors.lastname: Janga
authors.forename: Heladia
authors.initials: H
authors.lastname: Salgado
authors.forename: Julio
authors.initials: J
authors.lastname: Collado-Vides
mesh_terms: D004777:Environment; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D014157:Transcription Factors