title: Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G-U wobble base pairs.
abstract: Imidazole modification at C-5 of uridine that is part of tandem G-U wobble base pairs causes slight reduction of thermal stability (DeltaDeltaG(0)(310) < 0.4 kcal mol(-1)) and relatively small change in hydration of short RNA helices.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA. e.rozners@neu.edu
authors.forename: Eriks
authors.initials: E
authors.lastname: Rozners
authors.forename: Romualdas
authors.initials: R
authors.lastname: Smicius
authors.forename: Chika
authors.initials: C
authors.lastname: Uchiyama
mesh_terms: D020029:Base Pairing; D006150:Guanine Nucleotides / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D044366:Transition Temperature; D014500:Uracil Nucleotides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D006150:Guanine Nucleotides; D007093:Imidazoles; D014500:Uracil Nucleotides; D014867:Water; D012313:RNA; C029899:imidazole