title: HIV vaccine acceptability among communities at risk: the impact of vaccine characteristics.
abstract: HIV vaccines offer the best long-term hope of controlling the AIDS pandemic; yet, the advent of HIV vaccines will not ensure their acceptability. We conducted a cross-sectional survey (n=143), incorporating conjoint analysis, to assess HIV vaccine acceptability among participants recruited using multi-site (n=9), venue-based sampling in Los Angeles. We used a fractional factorial experimental design to construct eight hypothetical HIV vaccines, each with seven dichotomous attributes. The acceptability of each vaccine was assessed individually and then averaged across participants. Next, the impact of each attribute on vaccine acceptability was estimated for each participant using ANOVA and then analyzed across participants. Acceptability of the eight hypothetical HIV vaccines ranged from 33.2 (S.D. 34.9) to 82.2 (S.D. 31.3) on a 0-100 scale; mean=60.0 (S.D. 21.9). Efficacy had the greatest impact on acceptability (22.7; CI: 18.5-27.1; p<0.0001), followed by cross-clade protection (12.5; CI: 8.7-16.3, p<0.0001), side effects (11.5; CI: 7.4-15.5; p<0.0001), and duration of protection (6.1; CI: 3.2-9.0; p<.0001). Route of administration, number of doses and cost were not significant. Low acceptability of "partial efficacy" vaccines may present obstacles to future HIV vaccine dissemination. Educational and social marketing interventions may be necessary to ensure broad HIV vaccine uptake.
authors.affiliation: Centre for Applied Social Research, University of Toronto, Faculty of Social Work, 246 Bloor Street West, Toronto, Ont., Canada M5S 1A1. p.newman@utoronto.ca
authors.forename: Peter A
authors.initials: PA
authors.lastname: Newman
authors.forename: Naihua
authors.initials: N
authors.lastname: Duan
authors.forename: Sung-Jae
authors.initials: SJ
authors.lastname: Lee
authors.forename: Ellen T
authors.initials: ET
authors.lastname: Rudy
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Seiden
authors.forename: Lisa
authors.initials: L
authors.lastname: Kakinami
authors.forename: William E
authors.initials: WE
authors.lastname: Cunningham
mesh_terms: D016915:AIDS Vaccines / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D003153:Community Health Services; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control / Q000523:psychology; D007722:Health Knowledge, Attitudes, Practice; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D012307:Risk Factors; D012725:Sexual Behavior
chemical_list: D016915:AIDS Vaccines