title: Myocardial blood supply by left ventricle-to-coronary artery channel: an old idea revisited.
abstract: Coronary artery disease is one of the most important causes of death in Western society. Attempts to revascularize the coronary artery by myocardial retroperfusion, direct revascularization from the left ventricle, and bypass surgery have finally led to percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG) as standard treatment for coronary artery disease. Direct revascularization from the left ventricle has already been studied in the late 1960s, but the idea was rejected because of a decrease in flow in combination with a failure of myocardial function. Recently, a left ventricle-to-coronary artery (LV-CA) stent has renewed interest as an alternative procedure when PTCA and CABG are no option. Animal studies showed a change in flow pattern from diastolic coronary inflow at baseline to systolic coronary inflow followed by diastolic regurgitive flow during direct ventricular sourcing, resulting in a coronary flow of 50-75% of baseline flow. Global myocardial function decreased in the same extent as the coronary flow suggesting perfusion-contraction matching. In a recent pilot study in the anaesthetized pig, direct revascularization after acute proximal coronary ligation resulted in sufficient blood supply to the outer layers of the myocardium, however, in the inner layers a metabolic disbalance occurred. Incorporation of a valve-like mechanism to minimize the diastolic regurgitive flow may be necessary to improve the performance of the LV-CA stent. In addition, further research should be done in chronic ischemic animal models in which the effect of the collateral circulation on myocardial perfusion and performance is an important issue.
authors.affiliation: Heart Lung Center Utrecht, Experimental Cardiology Laboratory, University Medical Center Utrecht, The Netherlands.
authors.forename: Hannelie M
authors.initials: HM
authors.lastname: Engbers
authors.forename: Sandra
authors.initials: S
authors.lastname: de Zeeuw
authors.forename: Tjaakje
authors.initials: T
authors.lastname: Visser
authors.forename: Maarten-Jan M
authors.initials: MJ
authors.lastname: Cramer
authors.forename: Paul F
authors.initials: PF
authors.lastname: Gründeman
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000601:surgery*; D003331:Coronary Vessels / Q000601:surgery*; D006352:Heart Ventricles / Q000601:surgery*; D006801:Humans; D017551:Microdialysis; D009204:Myocardial Revascularization / Q000379:methods*; D009206:Myocardium / Q000378:metabolism*; D015607:Stents