Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model.
The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form III > Form I > dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed.
Carino
Stephen R
SR
Pfizer Corporation, Michigan Pharmaceutical Sciences, 7000 Portage Road, Kalamazoo, 49001, USA.
Sperry
David C
DC
Hawley
Michael
M
D000818:Animals; D001682:Biological Availability; D002220:Carbamazepine / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D003460:Crystallization; D004285:Dogs; D004386:Duodenum / Q000378:metabolism; D005215:Fasting; D005753:Gastric Mucosa / Q000378:metabolism; D008954:Models, Biological; D012995:Solubility
D002220:Carbamazepine