title: [Rhabdomyolysis as a side effect of simvastatin treatment].
abstract: Myopathy and rhabdomyolysis are rare adverse effects of treatment with hydroxymethylglutaryl-coA reductase inhibitors. The risk of adverse effects is increased with the concomitant use of statin and specific drugs that can induce myopathy, in patients with liver and renal function impairment, hypothyroidism and diabetes mellitus. The clinical picture of rhabdymyolysis with acute renal failure caused by the use of simvastatin in a 54-year-old patient with diabetes mellitus and hypertension is described.
authors.affiliation: Interni odjel, Opća bolnica Virovitica, Virovitica, Hrvatska.
authors.forename: Bosiljka
authors.initials: B
authors.lastname: Iskra
authors.forename: Marijana
authors.initials: M
authors.lastname: Zivko
authors.forename: Petar
authors.initials: P
authors.lastname: Kes
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D009220:Myositis / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000139:chemically induced*; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin