Cardiac development: new concepts.
Understanding normal development is a prerequisite to unraveling the mechanisms that underlie congenital heart disease, a critical step if one is to design rational new therapies. Over the past 20 years, human molecular genetics and developmental biology have provided a group of powerful tools to uncover a number of now well-defined pathways. There is now a confluence of new technologies and experimental systems that may allow for a more profound understanding in the near future.
Gruber
Peter J
PJ
Cardiac Center, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Suite 8527, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA. pgruber@mail.med.upenn.edu
D050991:GATA4 Transcription Factor / Q000502:physiology; D006321:Heart / Q000196:embryology*; D006330:Heart Defects, Congenital; D006801:Humans; D009154:Mutation; D020825:T-Box Domain Proteins / Q000502:physiology
D050991:GATA4 Transcription Factor; C484170:GATA4 protein, human; D020825:T-Box Domain Proteins; C108625:TBX1 protein, human