title: Effects of iEW synthetic peptide isomers on bone marrow colony-forming capacity in vivo.
abstract: Studies of cooperative effects of D- or L-isomers of iEW dipeptide and neuraminidase on the number of splenic CFU, comparison of the peptide effects on CD34+ cells and splenic CFU, and evaluation of the effects of iEW D- or L-isomers on parameters of T-cell activation showed that interactions of L-(iEW) and D-(iEW) with CD34+ surface receptors are realized through the same mechanism, while their different biological effects on hemopoietic precursor cells in vivo can be explained by their different influence on T-component of the microenvironment.
authors.affiliation: Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. ovs45@mail.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Semina
authors.forename: T N
authors.initials: TN
authors.lastname: Semenets
authors.forename: I A
authors.initials: IA
authors.lastname: Zamulaeva
authors.forename: E I
authors.initials: EI
authors.lastname: Selivanova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Malyutina
authors.forename: Yu A
authors.initials: YA
authors.lastname: Semin
authors.forename: V I
authors.initials: VI
authors.lastname: Deigin
authors.forename: A S
authors.initials: AS
authors.lastname: Saenko
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000032:analysis; D001854:Bone Marrow Cells / Q000187:drug effects*; D017252:CD3 Complex / Q000032:analysis; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D009439:Neuraminidase / Q000494:pharmacology; D013234:Stem Cells / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D018952:Antigens, CD34; D017252:CD3 Complex; D004151:Dipeptides; C508783:isoglutamyl-tryptophan; D009439:Neuraminidase