title: Severe hepatotoxicity after sevoflurane anesthesia in a child with mild renal dysfunction.
abstract: Sevoflurane, an anesthetic agent with methyl isopropyl fluorinated ether structure, has a very low potential for hepatotoxicity. Nevertheless, a few cases of hepatotoxicity have been reported since its introduction into clinical practice. The underlying pathophysiology may be multifactorial and sometimes nonspecific. We report a case of severe hepatotoxicity after anesthesia with sevoflurane in a child with preexisting mild renal dysfunction.
authors.affiliation: Department of Anesthesiology and Pain Medicine, School of Medicine, Keimyung University, Daegu, Korea. weonjo@dsmc.or.kr
authors.forename: Youngho
authors.initials: Y
authors.lastname: Jang
authors.forename: Insoo
authors.initials: I
authors.lastname: Kim
mesh_terms: D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000009:adverse effects* / Q000493:pharmacokinetics; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008738:Methyl Ethers / Q000009:adverse effects* / Q000493:pharmacokinetics; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane