title: Cell cycle: bistability is needed for robust cycling.
abstract: Xenopus egg extracts have distinct Cdk-active and Cdk-inactive states at intermediate cyclin concentrations, a phenomenon known as bistability. A new study shows that this behavior is important for robust cell cycling.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ingolia
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism*; D025461:Feedback, Physiological / Q000502:physiology*; D008954:Models, Biological; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*; D014981:Xenopus / Q000378:metabolism / Q000502:physiology*
chemical_list: D016213:Cyclins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D018844:Cyclin-Dependent Kinases