title: Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Jordan.
abstract: Molecular screening for glucose-6-phosphate (G6PD) mutations in two Jordanian populations revealed six different mutations and higher incidences of G6PD deficiency and G6PD A- (376A-->G + 202G-->A) mutation in Jordan Valley than in the Amman area. These observations may be explained by historically higher rates of malaria and African ancestral origins, respectively.
authors.forename: Naif S
authors.initials: NS
authors.lastname: Karadsheh
authors.forename: Linda
authors.initials: L
authors.lastname: Moses
authors.forename: Said I
authors.initials: SI
authors.lastname: Ismail
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Devaney
authors.forename: Eric
authors.initials: E
authors.lastname: Hoffman
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000349:Africa / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics; D018740:Genetic Heterogeneity; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology; D008297:Male
chemical_list: D005954:Glucosephosphate Dehydrogenase; C482910:glucose-6-phosphate dehydrogenase A-