title: Transient clonal expansion of T-large granular lymphocytes during primary cytomegalovirus infection.
abstract: Clonal immunoglobulin and T-cell receptor gene rearrangements are useful in distinguishing reactive lymphoproliferations from neoplastic processes. Here, we report a case of transient clonal expansion of CD8+ CD57- T-large granular lymphocytes (T-LGL) during primary cytomegalovirus infection. This case underlines that clonal expansion of T-LGL could be a reactive phenomenon related to an acute infectious disease and is not specific for lymphoid malignancy.
authors.affiliation: Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Dr Baylac, TSA 40031, 31059 Cedex 9, Toulouse, France. pierredelobel@yahoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Delobel
authors.forename: Aurélie
authors.initials: A
authors.lastname: Godel
authors.forename: Sophie
authors.initials: S
authors.lastname: Thebault
authors.forename: Laurent
authors.initials: L
authors.lastname: Alric
authors.forename: Michel
authors.initials: M
authors.lastname: Duffaut
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D002455:Cell Division; D002999:Clone Cells / Q000166:cytology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D008875:Middle Aged
chemical_list: D006684:HLA-DR Antigens