title: The prognostic importance of e-cadherin and p53 gene expression in transitional bladder carcinoma patients.
abstract: OBJECTIVE
  The clinical course of transitional cell carcinoma is highly variable. The determination of sensitive prognostic factors for transitional cell carcinoma is very important. Therefore e-cadherin and p53 immunohistochemical activity can be used with other prognostic factors.
  
  
  METHODS
  The study comprised with 61 (4 women and 57 men) selected patients who had transitional cell carcinoma. Paraffin embedded tissue sections were investigated immunohistochemically for e-cadherin normal staining and p53 over expression.
  
  
  RESULTS
  It is seen that when grade and stages of illness increased normal staining of e-cadherin decreased and p53 over expressed. Abnormal e-cadherin was significantly associated with disease recurrence (P < 0.001), disease progression (P < 0.001) and bladder specific survival. p53 differentiation was not significant for disease recurrence (P > 0.05) inverse to prognosis of illness. Transurethral resectomy and BCG treatments were not effected e-cadherin and p53 activity within the groups statistically.
  
  
  CONCLUSIONS
  Significant differences can be helpful to investigate patients more detailed pathologically. These expression rates in different type of transitional cell carcinoma patients may represent a biologically more aggressive cancer, requiring early definitive therapy. This hypothesis should be evaluated in larger studies and prospective clinical trials.
authors.affiliation: Sisli Etfal Research and Training Hospital, Ist Urology Clinics, Istanbul, Turkey.
authors.forename: Arisan
authors.initials: A
authors.lastname: Serdar
authors.forename: Caskurlu
authors.initials: C
authors.lastname: Turhan
authors.forename: Guney
authors.initials: G
authors.lastname: Soner
authors.forename: Sonmez Nurettin
authors.initials: SN
authors.lastname: Cem
authors.forename: Keles
authors.initials: K
authors.lastname: Bayram
authors.forename: Buyuktuncer Elif
authors.initials: BE
authors.lastname: Damla
authors.forename: Ergenekon
authors.initials: E
authors.lastname: Erbil
mesh_terms: D000293:Adolescent; D000328:Adult; D015820:Cadherins / Q000378:metabolism*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D016158:Genes, p53 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: D015820:Cadherins