title: Interaction between pesticides and essential metal copper increases the accumulation of copper in the kidneys of rats.
abstract: Male Sprague-Dawley rats, weighing 175-200 g, six per group were fed AIN 93M diet (CON) or diets containing 500 mg Ca (LCa), 7 mg Zn (LZn), 2 mg Cu (LCu), 60 mg Zn (HZn), or 12 mg Cu (HCu) per kilogram of diet in the following combinations: control (CON), LCa+LZn (LC+Z), LCa+LZn+LCu (LC+Z+C), or HZn+HCu (HZ+C) without or with a pesticides mixture (PM); Endosulfan, Thiram, and Acephate were added to the diets at 25% of LD50/kg. Rats were fed for 2 wk (small intestinal changes) or 4 wk (tissues changes). Plasma Zn was 47% lower than CON in the experimental groups. Plasma Cu and ceruloplasmin concomitantly decreased in the LC+Z+C group and increased with the addition of PM. Kidney Cu was 40% lower in LC+Z+C group, than CON and increased by 31% with PM; in the HZ+C+PM group, kidney Cu was 38% higher than the HZ+C group. Mucosal and small intestines Ca declined by 47% in all experimental groups; PM increased Zn in the LC+Z+C and HZ+C groups; PM further decreased intestinal and mucosal Cu retention in the LC+Z+C and HZ+C groups. Data suggest that low levels of PM in the diet can induce Cu accumulation in the kidney when dietary Zn and Cu are low or high.
authors.affiliation: Nutrition and Health Program, Atwood Research Facility, Kentucky State University, Frankfort, KY 40601, USA.
authors.forename: Myna
authors.initials: M
authors.lastname: Panemangalore
authors.forename: Frederick N
authors.initials: FN
authors.lastname: Bebe
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood / Q000378:metabolism*; D004032:Diet; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010575:Pesticides / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D015032:Zinc / Q000097:blood / Q000378:metabolism
chemical_list: D010575:Pesticides; D003300:Copper; D002570:Ceruloplasmin; D015032:Zinc; D002118:Calcium