title: Recovery and brain reorganization after stroke in adult and aged rats.
abstract: Stroke is a prevalent and devastating disorder, and no treatment is currently available to restore lost neuronal function after stroke. One unique therapy that improves recovery after stroke is neutralization of the neurite inhibitory protein Nogo-A. Here, we show, in a clinically relevant model, improved functional recovery and brain reorganization in the aged and adult rat when delayed anti-Nogo-A therapy is given after ischemic injury. These results support the efficacy of Nogo-A neutralization as treatment for ischemic stroke, even in the aged animal and after a 1-week delay, and implicate neuronal plasticity from unlesioned areas of the central nervous system as a mechanism for recovery.
authors.affiliation: Neuroscience & Aging Institute, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Tiffanie M
authors.initials: TM
authors.lastname: Markus
authors.forename: Shih-Yen
authors.initials: SY
authors.lastname: Tsai
authors.forename: Melanie R
authors.initials: MR
authors.lastname: Bollnow
authors.forename: Robert G
authors.initials: RG
authors.lastname: Farrer
authors.forename: Timothy E
authors.initials: TE
authors.lastname: O'Brien
authors.forename: Diana R
authors.initials: DR
authors.lastname: Kindler-Baumann
authors.forename: Martin
authors.initials: M
authors.lastname: Rausch
authors.forename: Markus
authors.initials: M
authors.lastname: Rudin
authors.forename: Christoph
authors.initials: C
authors.lastname: Wiessner
authors.forename: Anis K
authors.initials: AK
authors.lastname: Mir
authors.forename: Martin E
authors.initials: ME
authors.lastname: Schwab
authors.forename: Gwendolyn L
authors.initials: GL
authors.lastname: Kartje
mesh_terms: D000367:Age Factors; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002545:Brain Ischemia / Q000503:physiopathology / Q000628:therapy; D004195:Disease Models, Animal; D009185:Myelin Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology; D016501:Neurites / Q000502:physiology; D009473:Neuronal Plasticity; D000070798:Nogo Proteins; D051381:Rats; D020127:Recovery of Function; D020521:Stroke / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603197:Rtn4 protein, rat