title: Trends in the prevalence of Helicobacter pylori in symptomatic children in the era of eradication.
abstract: OBJECTIVE
  Helicobacter pylori infection is common in Asia and is associated with dyspepsia, peptic ulcer, and gastric cancer. Eradication of the organism remains an important goal. Here, we looked at the trends in the prevalence of H pylori in symptomatic children over an 8-year period to assess the impact of an aggressive eradication program.
  
  
  METHODS
  A retrospective review was carried out between 1997 and 2004. All children with a history of dyspepsia or acute gastrointestinal bleeding were included and underwent gastroscopy. Three antral biopsies were taken during endoscopy and sent for histological analysis. Positivity of H pylori was treated aggressively with quadruple therapy under protocol. The demographic data, the histological findings, and the H pylori status were recorded.
  
  
  RESULTS
  There were a total of 159 patients (71 males, 88 females) who underwent gastroscopy in this period. One hundred nineteen patients showed histological evidence of gastritis, and the positive rate of H pylori was 25.6%. The overall prevalence has not decreased (33.3% in 1997, 27.7% in 2004). Increasing age, however, was associated significantly with the higher risk of H pylori infection.
  
  
  CONCLUSIONS
  H pylori has a high prevalence in Chinese children with increasing age. Eradication efforts seem to be unsuccessful in the reduction of prevalence. We hypothesize that this may be owing to cross-infection at meal times from sharing chopsticks.
authors.affiliation: Department of Surgery, Queen Mary Hospital, University of Hong Kong Medical Centre, Hong Kong SAR, China.
authors.forename: Kenneth K Y
authors.initials: KK
authors.lastname: Wong
authors.forename: Patrick H Y
authors.initials: PH
authors.lastname: Chung
authors.forename: Lawrence C L
authors.initials: LC
authors.lastname: Lan
authors.forename: Steve C L
authors.initials: SC
authors.lastname: Lin
authors.forename: Paul K H
authors.initials: PK
authors.lastname: Tam
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001706:Biopsy; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013270:Stomach / Q000382:microbiology / Q000473:pathology