title: The use of celecoxib for reduction of pain after subpectoral breast augmentation.
abstract: A study was conducted to determine whether a single 400-mg dose of oral celecoxib administered 30 min before surgery reduces the opioid requirement for patients undergoing aesthetic subpectoral breast augmentation. A total of 695 patients undergoing breast augmentation were randomly selected into either a placebo or a treatment group. The findings showed that patients who received 400 mg of celecoxib 30 min before surgery required significantly fewer opioid analgesics after the operation than those given a placebo (p < 0.001). It also was found that nonsmokers and multiparous women required significantly fewer opioids than smokers and nulliparous women (p < 0.001). On the basis of this prospective study, the authors recommend a single 400-mg dose of celecoxib administered 30 min before surgery to decrease opioid analgesic requirements after subpectoral breast augmentation.
authors.affiliation: Department of Surgery, Plastic Surgery Division, University of Hawaii, John A. Burns School of Medicine, 1329 Lusitana Street, Suite 807, Honolulu, Hawaii 96813, USA.
authors.forename: Alan A
authors.initials: AA
authors.lastname: Parsa
authors.forename: Christopher W M
authors.initials: CW
authors.lastname: Soon
authors.forename: Fereydoun Don
authors.initials: FD
authors.lastname: Parsa
mesh_terms: D000293:Adolescent; D000328:Adult; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D010369:Pectoralis Muscles / Q000601:surgery*; D011720:Pyrazoles / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib