title: Identification of heavy metal complexes of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a voltammetric approach.
abstract: Complexation of the hexapeptide Hys-Cys-Lys-Phe-Trp-Trp, inhibitor of the human immunodeficiency virus integrase protein, with the heavy metal ions Cd2+, Pb2+, and Zn2+ has been investigated using differential pulse polarography. In the case of Pb2+, no significant complexation is detected, whereas in the cases of Cd2+ and Zn2+, strong and electrochemically inert ML2 complexes predominate. In contrast, ML complexes are present in a low proportion or are absent. When possible, the corresponding conditional stability constants have been determined at both pH 7.0 and pH 7.5, showing that Zn2+ complexes are slightly more stable than Cd2+ complexes.
authors.affiliation: Departament de Química Analítica, Facultat de Química, Universitat de Barcelona, E-08028 Barcelona, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Chekmeneva
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Díaz-Cruz
authors.forename: Cristina
authors.initials: C
authors.lastname: Ariño
authors.forename: Miquel
authors.initials: M
authors.lastname: Esteban
mesh_terms: D002104:Cadmium / Q000737:chemistry*; D019428:HIV Integrase Inhibitors / Q000737:chemistry*; D007854:Lead / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D011048:Polarography; D015032:Zinc / Q000737:chemistry*
chemical_list: D019428:HIV Integrase Inhibitors; D009842:Oligopeptides; D002104:Cadmium; D007854:Lead; D015032:Zinc