Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands.
A novel series of 5-HT(7) receptor ligands has been identified and evaluated, providing compounds showing a broad spectrum of functional activities and good selectivity over selected receptors and ion channels.
Raubo
Piotr
P
The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Harlow, Essex CM20 2QR, UK. piotr_raubo@merck.com
Beer
Margaret S
MS
Hunt
Peter A
PA
Huscroft
Ian T
IT
London
Clare
C
Stanton
Josephine A
JA
Kulagowski
Janusz J
JJ
D000478:Alkylation; D000586:Amination; D003500:Cyclization; D008024:Ligands; D015394:Molecular Structure; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*
D008024:Ligands; D011985:Receptors, Serotonin; D013450:Sulfones