title: Decreased pregnancy rate after in-vitro fertilization in HIV-infected women receiving HAART.
abstract: A study on in-vitro fertilization (IVF) was conducted among HIV-infected women. In these patients, a reduced pregnancy rate after IVF was observed if the patient's own oocytes were used. However, no significant reduction in the pregnancy rate was found if donated oocytes were used. The CD4 lymphocyte count was independently associated with ovarian resistance to hyperstimulation. Subclinical hypogonadism mediated by immunosuppression may explain these observations, suggesting the need to optimize the immunological status of the patient before considering assisted reproduction treatments.
authors.affiliation: Clinica Eugin, IDIBAPS, University of Barcelona, Barcelona, Spain.
authors.forename: Oriol
authors.initials: O
authors.lastname: Coll
authors.forename: Anna
authors.initials: A
authors.lastname: Suy
authors.forename: Francesc
authors.initials: F
authors.lastname: Figueras
authors.forename: Valérie
authors.initials: V
authors.lastname: Vernaeve
authors.forename: Esteban
authors.initials: E
authors.lastname: Martínez
authors.forename: Daniel
authors.initials: D
authors.lastname: Mataró
authors.forename: Mercè
authors.initials: M
authors.lastname: Durban
authors.forename: Montserrat
authors.initials: M
authors.lastname: Lonca
authors.forename: Ricard
authors.initials: R
authors.lastname: Vidal
authors.forename: José María
authors.initials: JM
authors.lastname: Gatell
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000032:analysis; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D009865:Oocytes / Q000276:immunology; D010053:Ovary / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology
chemical_list: D005640:Follicle Stimulating Hormone