Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
The design, synthesis, and structure-activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT(1A) receptor activities are described.
Zhou
Dahui
D
Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. zhoud@wyeth.com
Harrison
Boyd L
BL
Shah
Uresh
U
Andree
Terrance H
TH
Hornby
Geoffrey A
GA
Scerni
Rosemary
R
Schechter
Lee E
LE
Smith
Deborah L
DL
Sullivan
Kelly M
KM
Mewshaw
Richard E
RE
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D048588:Benzoxazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000928:Antidepressive Agents; D048588:Benzoxazines; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A