title: New cyclopentenone derivatives from an endophytic Streptomyces sp. isolated from the mangrove plant Aegiceras comiculatum.
abstract: From the mangrove plant Aegiceras comiculatum collected in South China an endophytic Streptomyces sp. was isolated. Following cultivation in a seawater-based medium, four new cyclopentenone derivatives, namely (5R) 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one (1), (5R) 5-hydroxy-3-[(methoxycarbonyl)amino]-5-vinyl-2-cyclopenten-1-one (2), (5R) 5-hydroxy-3-[[2-(4-hydroxyphenyl)ethyl]amino]-5-vinyl-2-cyclopenten-l-one (3), and 3-isobutylpropanamide-2-cyclopenten-l-one (4), were obtained from the fermentation broth. Their structures were elucidated by extensive spectroscopic (UV, IR, ESIMS, and 2D NMR) data analyses.
authors.affiliation: State Key Laboratories of Natural and Biomimetic Drugs, Beijing, 100083, P. R. China. whlin@bjmu.edu.cn
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Liya
authors.initials: L
authors.lastname: Li
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Fu
authors.forename: Isabel
authors.initials: I
authors.lastname: Sattler
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
authors.forename: Susanne
authors.initials: S
authors.lastname: Grabley
mesh_terms: D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029623:Primulaceae / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D003517:Cyclopentanes; C013905:cyclopentenone