title: Computer simulation of the influence of cellular adhesion on the morphology of the interface between tissues of proliferating and quiescent cells.
abstract: We investigate the influence of cellular adhesion on the morphology of the interface between a tissue of proliferating and quiescent cells using the cellular Potts model. We show that a decrease in surface tension changes the morphology of the interface and that only for negative surface tensions cell detachment from the proliferative tissue occurs suggesting that this might be a necessary condition for metastatization in malignant neoplasies.
authors.affiliation: Laboratório de Bioinformática e Biologia Computacional, Centro de Ciências Exatas e Tecnológicas, Universidade doVale do Rio dos Sinos, 93022-000 São Leopoldo, RS, Brazil.
authors.forename: Marcos A
authors.initials: MA
authors.lastname: Knewitz
authors.forename: José C M
authors.initials: JC
authors.lastname: Mombach
mesh_terms: D000465:Algorithms; D002448:Cell Adhesion; D049109:Cell Proliferation; D003198:Computer Simulation; D017709:Fractals; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D009361:Neoplasm Invasiveness