title: Recent progress in studies of pituitary tumor pathogenesis.
abstract: The mechanisms of tumorigenesis of the human pituitary have been elucidated to a limited extent. Classically, pituitary tumor formation was shown to be induced by thyroidectomy and estrogen administration. Molecular biological and immunohistochemical studies have revealed several aspects of pituitary tumorigenesis. Translineage cell differentiation has been shown to be induced by the aberrant expression of transcription factors and co-factors, such as Pit-1, Prop-1, and estrogen receptor. Defects or overexpression of cell cycle regulators, such as CDK inhibitors, PTTG, and GADD45gamma, result in the abnormal proliferation of pituitary cells. Recently, epigenetic regulation has been suggested to be related to pituitary tumor formation. This article presents a review and update of recent progress in studies of the development and differentiation of pituitary tumors.
authors.affiliation: Department of Pathology, Tokai University School of Medicine. Boseidai, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Minematsu
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Miyai
authors.forename: Hanako
authors.initials: H
authors.lastname: Kajiya
authors.forename: Masanori
authors.initials: M
authors.lastname: Suzuki
authors.forename: Naoko
authors.initials: N
authors.lastname: Sanno
authors.forename: Susumu
authors.initials: S
authors.lastname: Takekoshi
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
authors.forename: Robert Y
authors.initials: RY
authors.lastname: Osamura
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D010911:Pituitary Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D014157:Transcription Factors