Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India.
A study of organ-specific and organ-nonspecific autoantibodies was carried out in 21 children being followed up after a diagnosis of Kawasaki disease at a tertiary care center of North India. Anti-nuclear antibodies were detected in 9.5% patients while anti-thyroid microsomal antibodies were detected in 23.9% patients. Other autoantibodies (e.g. anti-parietal cell antibody, anti-liver kidney microsomal antibody anti-neutrophil cytoplasmic antibody, anti-mitochondrial antibody and anti-smooth muscle antibody) were not detected in any of our patients. Children with Kawasaki disease need to be monitored for the development of autoantibodies during follow-up.
Venkatraman
R
R
Department of Pediatrics and Immunopathology, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research (PGIMER), 160012, Chandigarh, India.
Singh
S
S
Minz
R W
RW
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008928:Mitochondria / Q000276:immunology; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D009130:Muscle, Smooth / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; C060729:anti-liver kidney microsome antibody; C056626:thyroid microsomal antibodies