Electron microscopic characteristics of beta2-microglobulin amyloid deposits in long-term haemodialysis.
The electron microscopic features of beta2-microglobulin amyloid, deposited in the synovial membrane, are presented and discussed. The patient, a 69-year-old woman underwent chronic hemodialysis for 3 years. Because of constant pain and destructive arthropathy, endoprosthesis of the hip joints were implanted. Extra- and intracellular filamentous-fibrillar amyloid deposits have been demonstrated in ultrathin sections. The extracellular amyloid deposits showed a loose, filamentous or fibrillar structure at the periphery and a dense central core. The loose, filamentous structure may represent an early stage of fresh, newly deposited beta2-microglobulin amyloid, while the condensed and fragmented amyloid filaments may be an advanced "mature" stage of amyloid deposition.
Bély
Miklós
M
Department of Pathology, Policlinic of the Hospitaller Brothers of St. John of God, Budapest, Hungary. dr.bely.miklos@axelero.hu
Kapp
Pál
P
Szabó
Tamás Szentjóbi
TS
Lakatos
Tamás
T
Apáthy
Agnes
A
D000368:Aged; D000682:Amyloid / Q000648:ultrastructure*; D000686:Amyloidosis / Q000209:etiology / Q000473:pathology; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D006621:Hip Joint / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007592:Joint Diseases / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000628:therapy; D046529:Microscopy, Electron, Transmission; D006435:Renal Dialysis / Q000009:adverse effects; D013583:Synovial Membrane / Q000648:ultrastructure*; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000648:ultrastructure*
D000682:Amyloid; D001613:beta 2-Microglobulin