title: Cytotoxic prenylflavonoids from Artocarpus elasticus.
abstract: Five new prenylated flavonoids, artelastoheterol (1), artelasticinol (2), cycloartelastoxanthone (3), artelastoxanthone (4), and cycloartelastoxanthendiol (5), along with five known compounds, were isolated from the root bark of Artocarpus elasticus. The structures of 1-5 were elucidated by spectroscopic methods and through comparison with data reported in the literature. The previously known compound artonol A (6) exhibited cytotoxic activity against the A549 human cancer cell line, with an ED50 value of 1.1 microg/mL.
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
authors.forename: Horng-Huey
authors.initials: HH
authors.lastname: Ko
authors.forename: Yi-Huang
authors.initials: YH
authors.lastname: Lu
authors.forename: Sheng-Zehn
authors.initials: SZ
authors.lastname: Yang
authors.forename: Shen-Jeu
authors.initials: SJ
authors.lastname: Won
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Lin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids