New naphthoquinones, f13102A and B, from a fungus strain F-13102.
Deficiency of Fas-mediated apoptosis is one of the mechanisms involved in the immune evasion by tumors. Thus, it might be a practical approach for cancer treatment that Fas-mediated apoptosis in tumor cells is modified by drugs. In the course of screening, we have isolated two new naphthoquinones, f13102A and B, from the culture broth of fungus strain F-13102. Coumpound f13102A sensitizes Fas-resistant human lung adenocarcinoma A549 cells to apoptosis.
Yoshimoto
Yuya
Y
Drug Development Unit, Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan.
Kawada
Manabu
M
Kumagai
Hiroyuki
H
Someno
Tetsuya
T
Inoue
Hiroyuki
H
Kawamura
Naoto
N
Isshiki
Kunio
K
Ikeda
Daishiro
D
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009285:Naphthoquinones; C507229:f13102A compound; C507230:f13102B compound