title: Short and efficient approach towards macrocyclic lactones based on a Sonogashira reaction.
abstract: Polyketide-derived macrolactones like zearalenone (1), zearalane (2) or curvularin (3) display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards this class of natural products by a combination of the Sonogashira and Mitsunobu reactions. The resulting lactone 9 was tested against human cancer cell lines at the NCI.
authors.affiliation: Department of Pharmacy, Zentrum für Pharmaforschung, LMU Munich, Germany. hjkra@cup.uni-muenchen.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Krauss
authors.forename: Doris
authors.initials: D
authors.lastname: Unterreitmeier
authors.forename: Christine
authors.initials: C
authors.lastname: Neudert
authors.forename: Franz
authors.initials: F
authors.lastname: Bracher
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; D047028:Macrocyclic Compounds