title: [Studies on immunoregulation of polysaccharides-la from Radix Cynanchi Bungei].
abstract: OBJECTIVE
  To study the effects of PRCB1a (one component of polysaccharides from Radix Cynanchi Bungei) on transformation of T lymphocytes of rabbit in vitro and immune function in mice.
  
  
  METHODS
  Three doses of PRCB1a (2,4,6 g x L(-1)) were respectively put in bottle with PHA and blood of rabbit. The effect of PRCB1a on immunity in vitro was studied by observing transformation of T lymphocytes; The dosage of PRCB1a (50,100,150 mg x kg(-1) x d(-1)) was given orally for seven days. The effects on immune function were investigated in mice.
  
  
  RESULTS
  Three doses of PRCB1a could significantly promote (P < 0.01) the ability of T lymphocytes proliferation; PRCB1a could improve the mouse thymus and spleen index, the celiac macrophage ability of engulfing CRBC, the delayed type hypersensitivity ability and the macrophage engulfing carbon granula ability.
  
  
  CONCLUSIONS
  The results indicate PRCB1a can enhance nonspectific and specific cellular immune function.
authors.affiliation: College of Pharmacy, Taishan Medical University, Taian 271000, China. ljgao.tsmc@126.com
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Gao
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Cui
authors.forename: Han-zhong
authors.initials: HZ
authors.lastname: Wang
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D031105:Cynanchum / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides