title: Lesion topography in capsulotomy for refractory anxiety--is the right side the right side?
abstract: OBJECTIVE
  A previous report on bilateral capsulotomy in obsessive-compulsive disorder showed common topographic features of lesions in the right-sided internal capsule in all patients responding to the treatment. The aims of the present study were to test if the same region was involved in anxiety patients responding to surgery and to examine whether lesion area and site correlated with adverse events and effect on target symptoms.
  
  
  METHODS
  Eleven anxiety patients who had undergone bilateral thermocapsulotomy were examined after 8-23 years. A quantitative MRI evaluation of the lesions within the internal capsule was conducted in three axial planes.
  
  
  RESULTS
  None of the eight responders had lesions that corresponded to the earlier reported right-sided anatomical denominator. Four patients out of 11 were rated as having significant clinical symptoms indicating frontal lobe dysfunction. The total sum of the lesion area determined in each of the three anatomical levels did not correlate with the degree of anxiety reduction. However, the lesion area appeared to be related to a rating of executive dysfunctioning, apathy and disinhibition.
authors.affiliation: Section for Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. christian.ruck@cns.ki.se
authors.forename: Christian
authors.initials: C
authors.lastname: Rück
authors.forename: Pär
authors.initials: P
authors.lastname: Svanborg
authors.forename: Björn A
authors.initials: BA
authors.lastname: Meyerson
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000000981:diagnostic imaging / Q000601:surgery*; D001925:Brain Damage, Chronic / Q000209:etiology*; D017115:Catheter Ablation / Q000009:adverse effects*; D004292:Dominance, Cerebral; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000293:injuries*; D006801:Humans; D020772:Internal Capsule / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012086:Reoperation; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome