title: [Effects of arsenic on reproductive and endocrine system of female rats].
abstract: OBJECTIVE
  Effects of arsenic on the levels of estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) in serum of female rats, as well as histopathological changes of ovary and adrenal gland were researched.
  
  
  METHODS
  The hormone levels of female rats were determined by RIA exposing arsenic for 10 weeks, and histopathological examination of ovary and adrenal gland were performed with light microscope.
  
  
  RESULTS
  In spite of LH, there was no levels of three hormones (P > 0.05). However, different extents of histopathological changes in ovary and adrenal gland were found.
  
  
  CONCLUSIONS
  LH is a sensitive index on hormones of female rats, but it may directly damage the reproductive system.
authors.affiliation: School of Public Health, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Tang
mesh_terms: D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood*; D010053:Ovary / Q000473:pathology*; D011388:Prolactin / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D001151:Arsenic