title: tRNA-isoleucine-tryptophan composite gene.
abstract: Transfer-RNA genes in archaea often have introns intervening between exon sequences. The structural motif at the boundary between exon and intron is the bulge-helix-bulge. Computational investigations of these boundary structures in Haloarcula marismortui lead us to propose that tRNA-isoleucine and tRNA-tryptophan genes are co-located. Precise in silico identification of the splice-sites on the bulges at the exon-intron boundaries lead us to infer that a single intron-containing composite tRNA-gene can give rise to more than one gene product.
authors.affiliation: Computational Biology Group, Theory Department, Indian Association for the Cultivation of Science, Calcutta 700032, India.
authors.forename: Zhumur
authors.initials: Z
authors.lastname: Ghosh
authors.forename: Jayprokas
authors.initials: J
authors.lastname: Chakrabarti
authors.forename: Bibekanand
authors.initials: B
authors.lastname: Mallick
authors.forename: Smarajit
authors.initials: S
authors.lastname: Das
authors.forename: Satyabrata
authors.initials: S
authors.lastname: Sahoo
authors.forename: Harmeet Singh
authors.initials: HS
authors.lastname: Sethi
mesh_terms: D000818:Animals; D001483:Base Sequence; D005091:Exons; D019766:Genes, Archaeal; D019614:Haloarcula marismortui / Q000235:genetics*; D007438:Introns; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012346:RNA, Transfer, Amino Acyl / Q000235:genetics*
chemical_list: D012346:RNA, Transfer, Amino Acyl