title: Intractable epilepsy in Turner syndrome associated with bilateral perisylvian hypoplasia: one case report.
abstract: Turner syndrome (TS) is the most frequent sex abnormality in females, generally associated with a 45,X0 karyotype. Although neurological complications are frequently part of the clinical picture, serious brain abnormalities are quite rare in TS. Epilepsy in TS is not frequent and so far only few cases have been reported, usually associated with cortical dysplasias. We report a Turner patient showing severe neurological impairment, refractory epilepsy and MRI finding of bilateral perisylvian hypoplasia. The possible dysgenetic role of X-chromosome on cortical morphogenesis is also discussed.
authors.affiliation: Epilepsy Center, Department of Neurological Sciences, Federico II University, Naples, Italy. sstriano@libero.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: Striano
authors.forename: Pasquale
authors.initials: P
authors.lastname: Striano
authors.forename: Fabio
authors.initials: F
authors.lastname: Tortora
authors.forename: Andrea
authors.initials: A
authors.lastname: Elefante
mesh_terms: D000328:Adult; D002535:Cerebral Aqueduct / Q000002:abnormalities*; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006801:Humans; D014424:Turner Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology