title: [Influence of estradiol benzoate on fluid reabsorption capacity of rat efferent ductuli].
abstract: OBJECTIVE
  To study the influence of estradiol benzoate (E2B) on the fluid reabsorption capacity of rat efferent ductuli.
  
  
  METHODS
  Newborn male Sprague-Dawley rats were injected subcutaneously with E2B (0.2 mg/5 g body weight), and the histological morphology of efferent ductulus, epithelial ultrastructure, and immunoexpression of AQP-1 were investigated on postnatal day 14, 21, 28, 42 and 56, respectively. Vehicle was given to the controls.
  
  
  RESULTS
  After exposure to E2B, the lumina of the efferent ductuli dilated greatly (P < 0.05), and the epithelium height decreased significantly (P < 0.01), microvilli of nonciliated cells short and sparse, endocytic apparatus implicated in fluid reabsorption scarce, and with no AQP-1 expression.
  
  
  CONCLUSIONS
  High dosage of E2 B neonatally administrated to rats damages the fluid reabsorption capacity of efferent ductuli.
authors.affiliation: Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China. zhangquan1291@sina.com.cn
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Zhou
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Zhang
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Zhou
authors.forename: De-Zhi
authors.initials: DZ
authors.lastname: Wang
authors.forename: Xi-Chang
authors.initials: XC
authors.lastname: Chen
mesh_terms: D000042:Absorption / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D051398:Aquaporin 1 / Q000096:biosynthesis; D001826:Body Fluids / Q000378:metabolism*; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D004958:Estradiol / Q000031:analogs & derivatives* / Q000633:toxicity; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure
chemical_list: C496022:Aqp1 protein, rat; D051398:Aquaporin 1; C074283:estradiol 3-benzoate; D004958:Estradiol