[Nitric oxide and blood coagulation system in clinical practice].
The article presents data concerning the effect of endothelium NO on vascular wall antithrombogenic properties, and the mechanism of NO antithrobogenic activity. The authors summarize the results of their own investigations and literature data on the role of thrombocyte NO in intravascular antithrombogenesis and the regulation of coagulation factors. Thrombocytes produce 16 times more NO then other blood cells do. A correlation between thrombocyte NO and several coagulation factors has been proved; thus complex study of NO effect on internal and external coagulation mechanisms, factors of fibrinolysis and their inhibitors, acute-phase inflammatory proteins, playing an important role in hemostasis, may bring new interesting findings. It is evident, that this knowledge will help to find ways of pathogenetic hemostasis regulation in various extremal conditions.
Abakumov
M M
MM
Golikov
P P
PP
D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*
D009569:Nitric Oxide