Toward the etiologies of congenital heart diseases.
Congenital heart disease remains a significant cause of morbidity and mortality. In recent years, significant advances in molecular genetics, improved understanding of morphogenesis, recognition of specific patterning of abnormalities within and between species, and the impact of the Human Genome Project have accounted for these advances. Continued rapid developments in genomics and proteomics are anticipated. Epidemiologic investigations continue to be necessary to assess the influence of the environment on genetics. We are on the threshold of influencing the occurrence of congenital heart diseases.
Pelech
Andrew N
AN
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, PO Box 26509, 8701 Watertown Plank Road, Milwaukee, WI 53266-0509, USA. apelech@chw.org
Broeckel
Ulrich
U
D006330:Heart Defects, Congenital / Q000209:etiology*; D006801:Humans