title: Pelvic insufficiency fracture related to autosomal dominant polycystic kidney disease.
abstract: We report the case of a patient with autosomal dominant polycystic kidney disease (ADPKD) and an insufficiency-type fracture of the pelvis. A 60-year-old Japanese woman was admitted because of pain in the right ischium and pubis that began suddenly with no precipitating cause. Computed tomography showed the bony pelvis to be compressed by enlarged dependent kidneys and an enlarged liver. We relieved compression on the pelvic bones by means of transarterial embolization (TAE) to the kidneys and liver after initiation of hemodialysis therapy. The fracture healed gradually after TAE, and the patient could walk 4 months later. In an iliac bone specimen obtained before TAE, cancellous bone was intact, but periosteal and endosteal surfaces of cortical bone showed marked resorption and were irregular. Normally, many ligaments are connected tightly to the periosteal surface, supporting the cortical bone. However, because of extensive surface resorption associated with pressure from enlarged kidneys, connections between ligaments and the periosteal surface presumably became fragile, promoting an insufficiency fracture from unapparent external forces. Thus, ADPKD is a potential cause of insufficiency fracture owing to abnormalities of cortical bone.
authors.affiliation: Nephrology Center, Department of Orthopedics, Toranomon Hospital Kajigaya, Kanagawa, Japan. ubara@toranomon.gr.jp
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Higa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tagami
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nomura
authors.forename: Kei
authors.initials: K
authors.lastname: Kadoguchi
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Katori
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Izuru
authors.initials: I
authors.lastname: Kitajima
authors.forename: Shigeko
authors.initials: S
authors.lastname: Hara
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
mesh_terms: D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology*; D003560:Cysts / Q000209:etiology / Q000473:pathology; D004621:Embolization, Therapeutic; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology*; D006529:Hepatomegaly / Q000150:complications*; D006801:Humans; D007269:Injections, Intra-Arterial; D007512:Ischium / Q000000981:diagnostic imaging / Q000293:injuries*; D007668:Kidney / Q000098:blood supply / Q000473:pathology*; D008099:Liver / Q000098:blood supply; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D017699:Pelvic Pain / Q000209:etiology*; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000473:pathology; D011312:Pressure; D011630:Pubic Bone / Q000000981:diagnostic imaging / Q000293:injuries*; D011859:Radiography; D006435:Renal Dialysis