title: Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor.
abstract: We examined the effects of 12 terpene compounds derived from the roots of Euphorbia kansui on the proliferative activity of Xenopus embryo cells. Eight of these compounds showed significant inhibition of cellular proliferation even at low concentrations, while four of them needed to be present at higher concentrations to inhibit cellular proliferation. In order to define the mechanism of inhibition of cellular proliferation by these compounds, the effects of diterpene compounds on the activity of topoisomerase II were measured. Most of the diterpene compounds that inhibited cellular proliferation also inhibited topoisomerase II activity.
authors.affiliation: Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajosui, Tokyo 156-8550, Japan. miyata@chs.nihon-u.ac.jp
authors.forename: Shohei
authors.initials: S
authors.lastname: Miyata
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Wang
authors.forename: Chisato
authors.initials: C
authors.lastname: Yoshida
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D004250:DNA Topoisomerases, Type II / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry; D005260:Female; D008297:Male; D059005:Topoisomerase II Inhibitors; D014982:Xenopus laevis
chemical_list: D004224:Diterpenes; D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II