Genomic and proteomic analysis of mammary tumors arising in transgenic mice.
Transforming growth factor-beta (TGF-beta) is the prototype of a large family of signaling molecules. TGF-beta signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-beta signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.
Xie
Lu
L
Department of Cancer Biology, Biostatistics Shared Resource, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA.
Xu
Baogang J
BJ
Gorska
Agnieszka E
AE
Shyr
Yu
Y
Schwartz
Sarah A
SA
Cheng
Nikki
N
Levy
Shawn
S
Bierie
Brian
B
Caprioli
Richard M
RM
Moses
Harold L
HL
D000595:Amino Acid Sequence; D000818:Animals; D014408:Biomarkers, Tumor; D016000:Cluster Analysis; D018076:DNA, Complementary / Q000378:metabolism; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics / Q000379:methods*; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D011506:Proteins / Q000737:chemistry; D020543:Proteome; D040901:Proteomics / Q000379:methods*; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D016212:Transforming Growth Factor beta / Q000378:metabolism; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D011506:Proteins; D020543:Proteome; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta