title: Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice.
abstract: The effect of ethanol extract obtained from Bulgaria inquinans on the scratching behavior and vascular permeability changes induced by compound 48/80, histamine and serotonin in ICR mice was studied. The extract dose-dependently inhibited scratching behavior induced by compound 48/80 and serotonin. A significant inhibition was observed at doses of 300 and 600 mg/kg when Bulgaria inquinans extract was administered orally. However, no inhibitory effect was observed on the histamine-induced scratching behavior by the extract, even at a dose of 600 mg/kg. In addition, it also inhibited the increase in the vascular permeability induced by compound 48/80 and serotonin at doses of 300 and 600 mg/kg; however, it failed to inhibit the increased vascular permeability induced by histamine, even at a dose of 600 mg/kg. Bulgaria inquinans extract showed a potent inhibitory effect on histamine release induced by compound 48/80. These results suggest that Bulgaria inquinans extract is effective in cutaneous pruritus and erythema, which were probably mediated by inhibiting the release of histamine from mast cells and antagonizing the effect on serotonin.
authors.affiliation: Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-naka, Okyama 700-8530, Japan.
authors.forename: Shuishi
authors.initials: S
authors.lastname: Jiang
authors.forename: Tae
authors.initials: T
authors.lastname: Tsumuro
authors.forename: Miho
authors.initials: M
authors.lastname: Takubo
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujii
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001203:Ascomycota / Q000737:chemistry* / Q000302:isolation & purification; D001522:Behavior, Animal / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D045424:Complex Mixtures / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004890:Erythema / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D005260:Female; D006632:Histamine / Q000009:adverse effects / Q000378:metabolism; D007665:Ketotifen / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin; D013535:Suspensions / Q000008:administration & dosage; D003189:p-Methoxy-N-methylphenethylamine
chemical_list: D045424:Complex Mixtures; D013535:Suspensions; D003533:Cyproheptadine; D012701:Serotonin; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D007665:Ketotifen