title: A randomized controlled trial of the use of self-help materials in addition to standard general practice treatment of depression compared to standard treatment alone.
abstract: BACKGROUND
  The purpose of the study was to examine whether the addition of a brief individual self-help package to standard primary-care treatment of depression with antidepressants is associated with any additional improvements in clinical outcome.
  
  
  METHODS
  Individuals with major depressive disorder who were prescribed an antidepressant were recruited through their general practitioner (GP) and allocated randomly to standard treatment alone or standard treatment plus self-help. Assessments of symptoms, social adjustment, global functioning, satisfaction with treatment and knowledge about the management of the disorder were completed at three time points over 26 weeks.
  
  
  RESULTS
  One hundred and twelve individuals agreed to participate and 96 met criteria for inclusion in the randomized controlled trial. Subjects in both treatment conditions improved substantially over the study period; the mean Beck Depression Inventory (BDI) score fell from 27.3 to 13.9 in the intention-to-treat analysis. There were no between group differences in outcome on any of the primary outcome measures, nor did these approach even marginal significance. Patients and GPs were highly satisfied with the self-help programme, and the intervention as compared to the control group reported significantly greater improvements in knowledge about depression and satisfaction with information received about depression.
  
  
  CONCLUSIONS
  An individualized self-help package improved perceived knowledge about depression but did not have identifiable effects on outcome when offered to patients treated in primary care. The study was sufficiently well powered to detect relatively small effects.
authors.affiliation: Department of Psychology, King's College London, Institute of Psychiatry, London, UK. p.salkovskis@iop.kcl.ac.uk
authors.forename: Paul
authors.initials: P
authors.lastname: Salkovskis
authors.forename: Katharine
authors.initials: K
authors.lastname: Rimes
authors.forename: Deborah
authors.initials: D
authors.lastname: Stephenson
authors.forename: Gerald
authors.initials: G
authors.lastname: Sacks
authors.forename: Jan
authors.initials: J
authors.lastname: Scott
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001364:Awareness; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012657:Self-Help Groups; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents