[Effect of electroacupuncture on metabolism of lipids in rats of obesity induced by sodium glutamate].
OBJECTIVE
To explore mechanisms of acupuncture for reducing of body weight.


METHODS
The rat obesity model was developed by subcutaneous injection of sodium glutamate solution, and the experimental rats were divided into a blank control group, a model group, an electroacupuncture group and a sibutramine group; blood TC, TG, HDL-C, LDL-C contents and lipoprotein lipase (LPL) activity, and serum leptin and insulin levels were determined.


RESULTS
The body weight and Lee's index, and TG, TC and LDL-C contents in the electroacupuncture group decreased significantly as compared with those in the model group (all P<0.01), the actions in the electroacupuncture group being superior to those in the sibutramine group; the HDL-C contents in both the electroacupuncture and the sibutramine groups were higher than that of the model group (P<0.01) with no significant difference between the electroacupuncture group and the sibutramine group; LPL activity in the electroacupuncture group increased significantly as compared with that in the model group (P<0.01); serum leptin and insulin levels in both the electroacupuncture group and the sibutramine group were lower than that in the model group (P<0.05, P<0.01), with no significant difference between the electroacupuncture group and the sibutramine group in the effect on insulin content, and the decrease of leptin level in the electroacupuncture group was more as compared with the sibutramine group (P<0.01).


CONCLUSIONS
Electroacupuncture can improve the status of high blood lipids, increase lipoprotein lipase activity, and regulate serum leptin and insulin levels in the obestic rat.
Wang
Shao-jin
SJ
College of TCM, Hebei Medical University, Shijiazhuang, China. shaojin26@163.com
Li
Qing
Q
She
Yan-fen
YF
Li
Ai-ying
AY
Xu
Hua-zhou
HZ
Zhao
Zhi-guo
ZG
D015669:Acupuncture Points; D000818:Animals; D015671:Electroacupuncture; D006801:Humans; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000378:metabolism; D051381:Rats; D012970:Sodium Glutamate
D008055:Lipids; D012970:Sodium Glutamate