Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system.
Osteoclasts are primary cells for physiological and pathological bone resorption, and receptor activator of nuclear factor-kappaB ligand (RANKL) is critically involved in the differentiation, activation, and survival of these cells. Recently, therapeutics for pathological bone destruction targeting RANKL pathways has attracted a great deal of attention. Herein, we review the recent advances in the research on osteoclast biology and discuss the advantages and disadvantages of anti-RANKL therapies.
Tanaka
Sakae
S
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. tanakas-ort@h.u-tokyo.ac.jp
Nakamura
Kozo
K
Takahasi
Naoyuki
N
Suda
Tatsuo
T
D000818:Animals; D017209:Apoptosis; D001172:Arthritis, Rheumatoid / Q000209:etiology; D001862:Bone Resorption / Q000209:etiology* / Q000628:therapy; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D002454:Cell Differentiation; D006023:Glycoproteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D016328:NF-kappa B / Q000502:physiology; D010010:Osteoclasts / Q000166:cytology / Q000502:physiology; D010024:Osteoporosis / Q000209:etiology; D053244:Osteoprotegerin; D010510:Periodontal Diseases / Q000209:etiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors* / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D015398:Signal Transduction; D048029:TNF Receptor-Associated Factor 6 / Q000502:physiology
D002352:Carrier Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D053244:Osteoprotegerin; D019253:Proto-Oncogene Proteins c-bcl-2; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; D048029:TNF Receptor-Associated Factor 6; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human