Ligand-induced acceleration of the intramolecular [3 + 2] cycloaddition between alkynes and alkylidenecyclopropanes.
[chemical reaction: see text]. Bulky phosphite L6 and several sterically robust phosphoramidites are excellent ligands for promoting the Pd-catalyzed [3 + 2] intramolecular cycloaddition between alkylidenecyclopropanes and alkynes. The use of these ligands allows for low catalyst loadings and facilitates the otherwise sluggish cycloaddition of hept-6-ynylidenecyclopropane systems.
Durán
Juan
J
Departamento de Química Orgánica y Unidad Asociada al CSIC, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Gulías
Moisés
M
Castedo
Luis
L
Mascareñas
José L
JL