Osteopontin expression in salivary gland tumours.
Osteopontin (OPN) is expressed in numerous carcinomas and plays a role in tumour development, invasion and metastasis. This study examines by immunohistochemistry the expression of OPN in normal salivary gland tissue and three types of salivary gland tumour: pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and polymorphous low grade adenocarcinoma (PLGA). PAs and PLGAs demonstrated higher levels of OPN than normal salivary gland tissue, while ACC, although showing a trend towards increased OPN, was not significantly different. The results of this study indicate that OPN expression is present in normal salivary gland tissue, and is increased in certain salivary gland tumours, but further investigation is necessary to clarify its role.
Darling
M R
MR
Department of Pathology, University of Western Ontario, 1151 Richmond Street, Room 4015 DSB, London, Ontario, Canada N6A 5C1. mark.darling@fmd.uwo.ca
Gauthier
M
M
Jackson-Boeters
L
L
Daley
T D
TD
Chambers
A F
AF
Tuck
A B
AB
D000230:Adenocarcinoma / Q000378:metabolism*; D008949:Adenoma, Pleomorphic / Q000378:metabolism*; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009363:Neoplasm Proteins / Q000378:metabolism*; D053495:Osteopontin / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism*
D009363:Neoplasm Proteins; D053495:Osteopontin