title: Cytogenetic study of 75 erythroleukemias.
abstract: Chromosomal abnormalities of erythroleukemia (EL) are often described as complex and unspecific. A retrospective study of 75 EL defined following the WHO classification was performed by the Groupe Francophone de Cytogénétique Hématologique (GFCH) in order to reexamine the cytogenetics of this infrequent leukemia subtype. Clonal chromosomal abnormalities were found in 57 patients (76%), distributed in 4 subgroups according to their ploidy status: pseudodiploid (16%), hypodiploid (47%), hyperdiploid (19%), and 18% mixed cases associating 2 different clones (hypodiploid+hyperdiploid) or (pseudodiploid+hyperdiploid). Complex rearrangements and hypodiploid chromosome number were widely dominant (50%). Partial or entire monosomies represented 56% of abnormalities. Chromosomes 5 and 7 were the most frequently involved (41 and 33 times, respectively), followed by chromosomes 8, 16, and 21 (19 times each). Unbalanced abnormalities were more frequent than balanced. All these kinds of abnormalities were observed in de novo as well as in secondary EL. Four out of 7 cases of "pure erythroid" leukemia were associated with a BCR-ABL fusion. Lastly, no chromosome abnormality specific to EL could be established. However, the large overlap of chromosomal abnormality patterns of EL (pure erythroid form excepted) and refractory anemia with excess of blasts in transformation (RAEB-t) favors the hypothesis of similarities between these 2 hematologic disorders.
authors.affiliation: Laboratoire d'Hématologie, Hôpital de Hautepierre, 67000 Strasbourg, France. michel.lessard@chru-strasbourg.fr
authors.forename: M
authors.initials: M
authors.lastname: Lessard
authors.forename: S
authors.initials: S
authors.lastname: Struski
authors.forename: V
authors.initials: V
authors.lastname: Leymarie
authors.forename: G
authors.initials: G
authors.lastname: Flandrin
authors.forename: M
authors.initials: M
authors.lastname: Lafage-Pochitaloff
authors.forename: M-J
authors.initials: MJ
authors.lastname: Mozziconacci
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authors.lastname: Talmant
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authors.lastname: Bastard
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authors.lastname: Charrin
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authors.lastname: Baranger
authors.forename: C
authors.initials: C
authors.lastname: Hélias
authors.forename: P
authors.initials: P
authors.lastname: Cornillet-Lefebvre
authors.forename: F
authors.initials: F
authors.lastname: Mugneret
authors.forename: C
authors.initials: C
authors.lastname: Cabrol
authors.forename: M-P
authors.initials: MP
authors.lastname: Pagès
authors.forename: D
authors.initials: D
authors.lastname: Fert-Ferret
authors.forename: F
authors.initials: F
authors.lastname: Nguyen-Khac
authors.forename: B
authors.initials: B
authors.lastname: Quilichini
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authors.initials: C
authors.lastname: Barin
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authors.lastname: Berger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D008875:Middle Aged; D011003:Ploidies; D012189:Retrospective Studies; D016019:Survival Analysis