title: [Do patients with ventricular septal defect need endocarditis prophylaxis?].
abstract: BACKGROUND
  Patients with ventricle septal defect are considered at higher risk of infectious endocarditis than the population in general. According to guidelines, these patients should receive prophylactic antibiotics prior to invasive procedures. Recently, several studies have been published that challenge this view.
  
  
  METHODS
  Based on searches in Medline, we discuss the risk of endocarditis and indication for antibiotic prophylaxis in patients with this defect.
  
  
  RESULTS
  Patients with perimembranous and subvalvular defects have higher risk of endocarditis than the population in general. The proportion of patients developing endocarditis in relation to invasive procedures is low. Prophylactic antibiotics are only partially effective.
  
  
  CONCLUSIONS
  The proportion of preventable cases of endocarditis is low, and the prophylaxis does not give sufficient protection. Studies suggest that only patients at the highest risk should receive prophylactics.
authors.affiliation: Seksjon for pediatri, Institutt for klinisk medisin, Haukeland Universitetssjukehus, 5021 Bergen. helgamit@online.no
authors.forename: Helga
authors.initials: H
authors.lastname: Midtbø
authors.forename: Asle
authors.initials: A
authors.lastname: Hirth
authors.forename: Gunnar
authors.initials: G
authors.lastname: Norgård
authors.forename: Gottfried
authors.initials: G
authors.lastname: Greve
mesh_terms: D019072:Antibiotic Prophylaxis; D004697:Endocarditis, Bacterial / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D006345:Heart Septal Defects, Ventricular / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D017410:Practice Guidelines as Topic; D012307:Risk Factors