title: Anti-inflammatory activity of cacalol and cacalone sesquiterpenes isolated from Psacalium decompositum.
abstract: The hexane extract and two sesquiterpenic compounds, cacalol and cacalone, were isolated from the roots and rhizomes of Psacalium decompositum. Then, their anti-inflammatory activity was evaluated in carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema. Indomethacin was used as the anti-inflammatory agent of reference. In the rat paw model of inflammation, both the hexane extract and the sesquiterpenes isolated from Psacalium decompositum showed a clear dose-dependent inhibition of the carrageenan-induced edema (P < 0.05), with important differences among them during the temporal course of the inhibition. In the TPA-induced mouse ear edema all tested compounds showed anti-inflammatory activity in dose-dependent manner (P < 0.05). In both models, cacalone showed the most prominent anti-inflammatory activity. We conclude that some of the beneficial effects attributed to Psacalium decompositum in traditional medicine can be related with the anti-inflammatory activity of cacalol and cacalone.
authors.affiliation: Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Coyoacan 04510, México D.F., Mexico. manuelj@servidor.unam.mx
authors.forename: M
authors.initials: M
authors.lastname: Jimenez-Estrada
authors.forename: R Reyes
authors.initials: RR
authors.lastname: Chilpa
authors.forename: T Ramirez
authors.initials: TR
authors.lastname: Apan
authors.forename: Fernando
authors.initials: F
authors.lastname: Lledias
authors.forename: Wilhem
authors.initials: W
authors.lastname: Hansberg
authors.forename: Daniel
authors.initials: D
authors.lastname: Arrieta
authors.forename: F J Alarcon
authors.initials: FJ
authors.lastname: Aguilar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D012717:Sesquiterpenes; C497192:cacalol; C515649:cacalone; D002351:Carrageenan