title: Accuracy of fetal lung volume assessed by three-dimensional sonography.
abstract: OBJECTIVE
  To determine the accuracy and precision of prenatal three-dimensional (3D) ultrasound in estimating fetal lung volume using the rotational multiplanar technique (VOCAL) by comparing it to postmortem volume measurements.
  
  
  METHODS
  Fetal lung volume was measured during 3D ultrasound examination using a rotational multiplanar technique in eight cases of congenital diaphragmatic hernia (CDH) (six left and two right-sided) and in 25 controls without pulmonary malformation, immediately before termination. Prenatal 3D sonographic estimates of fetal lung volume were compared with postmortem measurement of fetal lung volume achieved by water displacement.
  
  
  RESULTS
  The intraclass correlation coefficient of fetal lung volume estimated by 3D ultrasound and measured at postmortem examination was 0.95 in CDH cases and 0.99 in controls. Based on Bland-Altman analysis, the bias, precision and limits of agreement were, respectively, 0.35 cm(3), 1.46 cm(3) and between -2.51 and + 3.21 cm(3) in cases with CDH and 0.08 cm(3), 2.80 cm(3) and between -5.41 and + 5.57 cm(3) in controls. The mean relative error of 3D ultrasound fetal lung volume measurement was -7.19% (from -42.70% to + 18.11%) in CDH cases and -0.72% (from -30.25% to + 19.22%) in controls, while the mean absolute error of 3D ultrasound fetal lung volume measurement was 1.40 (range, 0.71-2.52) cm(3) and 2.12 (range, 0.05-4.98) cm(3), respectively. Accuracy of 3D ultrasound for measuring fetal lung volumes was 84.86 (range, 57.30-99.48)% in cases with CDH and 91.38 (range, 69.75-99.45)% in controls. The mean intraobserver variability for lung volume estimated by 3D ultrasound was 0.28 cm(3) in controls and 0.17 cm(3) in CDH cases.
  
  
  CONCLUSIONS
  Prenatal 3D ultrasound can estimate accurately fetal lung volume using the rotational multiplanar technique for volume measurements (VOCAL), even in fetuses with very small lungs, such as cases with isolated CDH.
authors.affiliation: Maternité, Hôpital Necker-Enfants Malades, AP-HP, Université Paris V, Paris, France. rodrigoruano@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Ruano
authors.forename: J
authors.initials: J
authors.lastname: Martinovic
authors.forename: M
authors.initials: M
authors.lastname: Dommergues
authors.forename: M-C
authors.initials: MC
authors.lastname: Aubry
authors.forename: Y
authors.initials: Y
authors.lastname: Dumez
authors.forename: A
authors.initials: A
authors.lastname: Benachi
mesh_terms: D000029:Abortion, Legal; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D006548:Hernia, Diaphragmatic / Q000000981:diagnostic imaging* / Q000473:pathology; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008168:Lung / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology / Q000473:pathology; D008176:Lung Volume Measurements / Q000379:methods; D015588:Observer Variation; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods