title: On the dielectric behaviour of collagen-algal sulfated polysaccharide blends: effect of glutaraldehyde crosslinking.
abstract: In this paper, impedance measurements in the frequency range from 10(-2) to 10(6) Hz are presented for collagen and algal sulfated polysaccharide crosslinked films. We are considering the development of new biomaterials which have potential applications in coating of cardiovascular prostheses, support for cellular growth and in systems for controlled drug delivery. The effect of crosslink sulfated polysaccharide on the physical chemical properties of collagen was studied using FT-infrared spectroscopy, differential scanning calorimetry (DSC), dielectric spectroscopy. The resulting films crosslinked with glutaraldehyde (GA) in concentrations of 0.001% and 0.05% when analysed by DSC, showed that the GA treatment not only left the thermal stability of the collagen unaffected, but it also decreased the thermal transition energy. Dielectric spectroscopy shows that the effect of the crosslink on the blend film was associated to the decrease and stabilization of the dielectric permittivity at low frequencies and decreased its conductivity.
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors.forename: S D
authors.initials: SD
authors.lastname: Figueiró
authors.forename: A A M
authors.initials: AA
authors.lastname: Macêdo
authors.forename: M R S
authors.initials: MR
authors.lastname: Melo
authors.forename: A L P
authors.initials: AL
authors.lastname: Freitas
authors.forename: R A
authors.initials: RA
authors.lastname: Moreira
authors.forename: R S
authors.initials: RS
authors.lastname: de Oliveira
authors.forename: J C
authors.initials: JC
authors.lastname: Góes
authors.forename: A S B
authors.initials: AS
authors.lastname: Sombra
mesh_terms: D001672:Biocompatible Materials; D002152:Calorimetry, Differential Scanning; D003094:Collagen / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004563:Electrochemistry; D056890:Eukaryota / Q000737:chemistry*; D005976:Glutaral / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013431:Sulfates / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D011134:Polysaccharides; D013431:Sulfates; D003094:Collagen; D005976:Glutaral