Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia.
The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).
Stams
Wendy A G
WA
den Boer
Monique L
ML
Beverloo
H Berna
HB
Kazemier
Karin M
KM
van Wering
Elisabeth R
ER
Janka-Schaub
Gritta E
GE
Pieters
Rob
R
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D000970:Antineoplastic Agents / Q000494:pharmacology; D001215:Asparaginase / Q000494:pharmacology; D001402:B-Lymphocytes / Q000187:drug effects* / Q000473:pathology; D001854:Bone Marrow Cells / Q000187:drug effects / Q000201:enzymology; D002087:Butyrates / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D050676:Core Binding Factor Alpha 2 Subunit / Q000032:analysis*; D047630:Depsipeptides / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D022423:Myeloid Cells / Q000187:drug effects; D015514:Oncogene Proteins, Fusion / Q000032:analysis*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology; D000097764:ETS Translocation Variant 6 Protein
D000903:Antibiotics, Antineoplastic; D000944:Antigens, Differentiation, B-Lymphocyte; D000970:Antineoplastic Agents; D001215:Asparaginase; D002087:Butyrates; D050676:Core Binding Factor Alpha 2 Subunit; D047630:Depsipeptides; D056572:Histone Deacetylase Inhibitors; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein; C087123:romidepsin