Dichotomins J and K, vasodilator cyclic peptides from Stellaria dichotoma.
Two new cyclic peptides, dichotomins J (1) and K (2), have been isolated from the roots of Stellaria dichotoma, and their structures were elucidated by chemical degradation and extensive 2D NMR methods. Dichotomins J (1) and K (2) showed a moderate vasorelaxant effect on rat aorta.
Morita
Hiroshi
H
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
Iizuka
Toru
T
Choo
Chee-Yan
CY
Chan
Kit-Lam
KL
Itokawa
Hideji
H
Takeya
Koichi
K
D000818:Animals; D001011:Aorta / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D029752:Stellaria / Q000737:chemistry*; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D010456:Peptides, Cyclic; D014665:Vasodilator Agents; C506508:dichotomin J; C506509:dichotomin K