title: Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power.
abstract: The antioxidant properties of substituted diarylamines in the benzo[b]thiophene series were evaluated by their reducing power and free radical scavenging activity. The results were compared with those of standards: acid ascorbic for the first method and BHA and BHT for the second. For both methods it was possible to establish some structure-activity relationships (SARs) based on the position of the arylamination on the benzo[b]thiophene moiety, the presence of different substituents on the phenyl ring (F, 1 or 2 OMe) and on the thiophene ring (H, CO(2)Et, CO(2)H).
authors.affiliation: Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Sta. Apolónia, Apartado 1172, 5301-855 Bragança, Portugal. iferreira@ipb.pt
authors.forename: Isabel C F R
authors.initials: IC
authors.lastname: Ferreira
authors.forename: Maria-João R P
authors.initials: MJ
authors.lastname: Queiroz
authors.forename: Miguel
authors.initials: M
authors.lastname: Vilas-Boas
authors.forename: Letícia M
authors.initials: LM
authors.lastname: Estevinho
authors.forename: Agathe
authors.initials: A
authors.lastname: Begouin
authors.forename: Gilbert
authors.initials: G
authors.lastname: Kirsch
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001205:Ascorbic Acid; D002384:Catalysis; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010165:Palladium / Q000737:chemistry; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000588:Amines; D000975:Antioxidants; D016166:Free Radical Scavengers; D013876:Thiophenes; C088015:benzothiophene; D010165:Palladium; D001205:Ascorbic Acid