title: [Differential display of homeobox gene expressions in the normal, wounded human fetal and adult skins by DNA microarray].
abstract: OBJECTIVE
  To explore the differential expression of homeobox genes in the normal, wounded human fetal and adult skins and its significance in fetal scarless healing.
  
  
  METHODS
  Gene chips containing 14 000 human genes were used to investigate homeobox gene expressions of the normal, wounded human fetal and adult skins.
  
  
  RESULTS
  There were significant differences between the expression of homeobox genes, especially for PRX-2, HOXB13, HOXB6 and HOXB7.
  
  
  CONCLUSIONS
  The homeobox gene is in close relation to developmental biology. The different expressions and changes of homeobox genes in the normal, wounded human fetal and adult skin may be a primary cause of different wound healing between fetal and adult skin.
authors.affiliation: Department of Burns and Plastic Surgery, Burn Institute, the 304th Hospital Affiliated to PLA General Hospital, Beijing 100037, China.
authors.forename: Hui-Feng
authors.initials: HF
authors.lastname: Song
authors.forename: Jia-Ke
authors.initials: JK
authors.lastname: Chai
authors.forename: Min-Liang
authors.initials: ML
authors.lastname: Chen
authors.forename: Zi-Hao
authors.initials: ZH
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D002648:Child; D005260:Female; D005333:Fetus; D015870:Gene Expression; D020869:Gene Expression Profiling; D005801:Genes, Homeobox / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020411:Oligonucleotide Array Sequence Analysis; D012867:Skin; D014945:Wound Healing / Q000235:genetics*; D055815:Young Adult
chemical_list: D018398:Homeodomain Proteins