Radiation and the microenvironment - tumorigenesis and therapy.
Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.
Barcellos-Hoff
Mary Helen
MH
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA. mhbarcellos-hoff@lbl.gov
Park
Catherine
C
Wright
Eric G
EG
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D002477:Cells / Q000528:radiation effects*; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced; D011839:Radiation, Ionizing