title: Protein tyrosine-phosphatase expression profiling in gastric cancer tissues.
abstract: Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination.
authors.affiliation: Department of Surgery, Veterans General Hospital, Taipei, Taiwan, ROC.
authors.forename: Chew-Wun
authors.initials: CW
authors.lastname: Wu
authors.forename: Hwa-Li
authors.initials: HL
authors.lastname: Kao
authors.forename: Anna F-Y
authors.initials: AF
authors.lastname: Li
authors.forename: Chin-Wen
authors.initials: CW
authors.lastname: Chi
authors.forename: Wen-Chang
authors.initials: WC
authors.lastname: Lin
mesh_terms: D000368:Aged; D011508:Chondroitin Sulfate Proteoglycans / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis*; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; D011956:Receptors, Cell Surface; C516841:PTPRA protein, human; C516895:PTPRZ1 protein, human; D017027:Protein Tyrosine Phosphatases; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5