title: Oligo- and poly-nucleotides: 50 years of chemical synthesis.
abstract: It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3'-->5'-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described.
authors.affiliation: Department of Chemistry, King's College London, Strand, London, UK. colin.reese@kcl.ac.uk
authors.forename: Colin B
authors.initials: CB
authors.lastname: Reese
mesh_terms: D007202:Indicators and Reagents; D008722:Methods; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000737:chemistry; D011119:Polynucleotides / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D011119:Polynucleotides