title: Multicomponent domino reaction from beta-ketoamides: highly efficient access to original polyfunctionalized 2,6-diazabicyclo[2.2.2]octane cores.
abstract: We describe a new multicomponent domino reaction from beta-ketoamides, involved as substrates and as nucleophilic partners. We obtain highly functionalized and original 2,6-diazabicyclo[2.2.2]octane cores (2,6-DABCO) in a five-step one-pot sequence, which is fast, environmentally friendly, operationally simple to manage, and combines step- and atom-economic aspects.
authors.affiliation: Université Paul Cézanne (Aix-Marseille III), CNRS UMR 6178, SYMBIO, Faculté des Sciences et Techniques, Case D12-13397, Marseille Cedex 20, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Liéby-Muller
authors.forename: Thierry
authors.initials: T
authors.lastname: Constantieux
authors.forename: Jean
authors.initials: J
authors.lastname: Rodriguez