[Effects of penile vasoactive mediators on the development of erectile dysfunction].
Penile corpus cavernosum can be seen as a special kind of vascular structure. The cause of erectile dysfunction (ED) is often related to the changes of penile vasoactive mediators which modulate the functional conditions of penile erectile tissues. The penile vasoactive mediators including angiotensin and kinins, prostaglandins, endothelins, endothelium-derived hyperpolarizing factors (EDHF), NOS and NO, RhoA/Rho-kinases, etc., may play an important role in the development of ED. Further researches on these mediators can furnish some theoretical evidence for the clinical treatment of ED.
Li
San-Xiang
SX
Department of Urology, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical College, Nanjing, Jiangsu 210008, China. ytdai@hotmail.com
Dai
Yu-Tian
YT
D000809:Angiotensins / Q000502:physiology; D000818:Animals; D004285:Dogs; D016232:Endothelins / Q000502:physiology; D007172:Erectile Dysfunction / Q000503:physiopathology*; D006801:Humans; D007705:Kinins / Q000502:physiology; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000502:physiology; D010413:Penis / Q000098:blood supply*; D011453:Prostaglandins / Q000502:physiology; D051381:Rats
D000809:Angiotensins; D016232:Endothelins; D007705:Kinins; D011453:Prostaglandins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase