Effect of congenital heart disease on neurodevelopmental outcomes within multiple-gestation births.
OBJECTIVE
We sought to assess the effect of congenital heart disease requiring surgical intervention with cardiopulmonary bypass at 6 months of age or less on developmental outcomes and growth at 1 year of age while controlling for socioeconomic status, prematurity, home environment, and parental intelligence.


METHODS
We performed within-family comparison of 11 multiple-gestation births in which one child had congenital heart disease. At 1 year of age, the Bayley Scales of Infant Development II were administered, and growth parameters were assessed. Paired comparisons were made by using fixed effects regression conditioned on family.


RESULTS
The multiple-gestation subjects were mildly premature on average (mean gestational age, 35.4 +/- 3.0 weeks). At 1 year of age, children with congenital heart disease scored lower on the Mental Development Index (85.0 +/- 19.3 vs 93.9 +/- 16.0, P = .037) and the Psychomotor Development Index (76.6 +/- 16.9 vs 91.3 +/- 14.9, P = .015) on the Bayley Scales of Infant Development II than did their siblings without congenital heart disease. There were no differences between siblings in weight, height, or head circumference.


CONCLUSIONS
The presence of congenital heart disease requiring surgical intervention with cardiopulmonary bypass at 6 months of age or less is associated with a deficit in developmental achievement at 1 year of age, as measured by using the Bayley Scales of Infant Development II.
Schultz
Amy H
AH
Division of Cardiology, The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pa, USA. ahschultz@uwalumni.com
Jarvik
Gail P
GP
Wernovsky
Gil
G
Bernbaum
Judy
J
Clancy
Robert R
RR
D'Agostino
Jo Ann
JA
Gerdes
Marsha
M
McDonald-McGinn
Donna
D
Nicolson
Susan C
SC
Spray
Thomas L
TL
Zackai
Elaine
E
Gaynor
J William
JW
D005260:Female; D006331:Heart Diseases / Q000150:complications* / Q000151:congenital*; D006801:Humans; D007223:Infant; D008297:Male; D011596:Psychomotor Disorders / Q000453:epidemiology* / Q000209:etiology*; D014310:Triplets; D014427:Twins