title: Reconstruction as a source of artifact in non-gated single-shot diffusion-weighted EPI.
abstract: A controversy has existed over the requirement to cardiac gate diffusion-weighted MRI acquisitions of the brain. Conventional wisdom suggests gating to be a necessary requirement to allow acquisition of accurate data, but recent applications find gating not necessary. The signal-to-noise and acquisition duration of these two approaches can be quite different; thus, this difference in methodology is important. This is particularly relevant when performing quantitative work such as diffusion tensor imaging. Here, the convention to gate is explained as being due to the historical use of low spatial resolution and more recently to the use of different reconstruction approaches. It is demonstrated that the Margosian reconstruction approach only yields high quality results when used in a gated fashion. Zero padding of the acquisition matrix provides an alternative reconstruction method that is not found to accentuate the artifacts that are due to pulsatile motion in the diffusion-weighted acquisition and thus do not require a gated acquisition. The relative merits of each reconstruction approach are discussed, including estimates of the relative signal-to-noise ratio and resolution benefits. It is concluded that both gated methods and non-gated methods can each provide high quality results with appropriate reconstruction methods.
authors.affiliation: MRS Unit, John Radcliffe Hospital, Oxford University Centre for Clinical Magnetic Resonance Research, OX3 9DU Oxford, UK. matthew.robson@cardio.ox.ac.uk
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Robson
authors.forename: David A
authors.initials: DA
authors.lastname: Porter
mesh_terms: D016477:Artifacts; D001931:Brain Mapping / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted