MRI study of corpus callosum in children and adolescents with bipolar disorder.
This structural magnetic resonance imaging study examined the length, areas, and circularity of the corpus callosum (CC) in 16 children and adolescents with bipolar disorder and 21 healthy controls. Bipolar disorder patients had lower circularity of the CC splenium compared with healthy controls. No significant differences in CC length or area were observed, suggesting that reported CC abnormalities appear late in the course of bipolar disorder.
Yasar
A Sibel
AS
MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program), Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA.
Monkul
E Serap
ES
Sassi
Roberto B
RB
Axelson
David
D
Brambilla
Paolo
P
Nicoletti
Mark A
MA
Hatch
John P
JP
Keshavan
Matcheri
M
Ryan
Neal
N
Birmaher
Boris
B
Soares
Jair C
JC
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis*; D002648:Child; D003337:Corpus Callosum / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male