title: Safety and efficacy of cytoreductive surgery for epithelial ovarian cancer in elderly and high-risk surgical patients.
abstract: OBJECTIVE
  Surgery is the cornerstone of management in ovarian cancer. However, in high-risk and elderly patients there is a tendency for less aggressive surgery upfront. The aim of this study was to review cytoreductive surgery, with focus on complications and outcomes in patients with multiple surgical risk factors.
  
  
  METHODS
  Charts of patients with ovarian cancer from 1998 to 2002 were retrospectively reviewed.
  
  
  RESULTS
  One hundred and forty patients were treated for ovarian cancer. Sixty-three patients (45%) were elderly (> or =65 years), and 69 patients (49%) had comorbidities. Optimal debulking (< or =1 cm) was achieved in 123 patients (88%). There was no significant relation between complications and type of procedure, elderly age, comorbidities, or transfusions. Optimally debulked patients had a significantly longer survival than patients with suboptimal debulking (P < .001).
  
  
  CONCLUSIONS
  Aggressive optimal cytoreduction can be achieved in the majority of patients with multiple surgical risk factors and is associated with a low complication rate.
authors.affiliation: Division of Gynecologic Oncology, Department of Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Sameer
authors.initials: S
authors.lastname: Sharma
authors.forename: Deborah
authors.initials: D
authors.lastname: Driscoll
authors.forename: Kunle
authors.initials: K
authors.lastname: Odunsi
authors.forename: Arun
authors.initials: A
authors.lastname: Venkatadri
authors.forename: Shashikant
authors.initials: S
authors.lastname: Lele
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000601:surgery*; D010052:Ovariectomy; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis