In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach.
Obach
R Scott
RS
Department of Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton Laboratories MS 4088, Groton, CT 06340, USA. r.scorr.orbach@pfizer.com
Walsky
Robert L
RL
Venkatakrishnan
Karthik
K
Houston
J Brian
JB
Tremaine
Larry M
LM
D000465:Algorithms; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003627:Data Interpretation, Statistical; D004347:Drug Interactions; D006801:Humans; D008657:Metabolic Clearance Rate; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D036301:Qualitative Research
D065607:Cytochrome P-450 Enzyme Inhibitors; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System