title: Impact of endograft material on the inflammatory response after elective endovascular abdominal aortic aneurysm repair.
abstract: The purpose of this paper is to examine the impact of endograft material on the inflammatory response after elective endovascular abdominal aortic aneurysm repair. Consecutive patients (n = 22, all men, 53 to 82 years old) were divided into 2 groups according to the graft material used: In group A (n = 12) the endovascular device was made of polyester and in group B (n = 10) the device was made of expanded polytetrafluoroethylene (ePTFE). All patients received antiinflammatory drugs in the perioperative period. Fever, white blood cells and platelet count, serum concentrations of cytokines (interleukin 6 [IL-6], tumor necrosis factor alpha [TNF-alpha], interleukin 8 [IL-8], acute-phase proteins high-sensitivity C-reactive protein [hsCRP] and alpha1-antitrypsin [alpha1-antitrypsin]), and complement protein (C3a) were measured preoperatively and 1, 3, 6, 24, 48, and 72 hours after aneurysm exclusion. One patient in each group had a systemic inflammatory response syndrome with 2 of the systemic inflammatory response syndrome (SIRS) criteria. No other complication associated with inflammation were present in any patient. Fever was more frequent in group A patients. Increases of white blood cells and serum concentrations of IL-6, TNF-alpha, hsCRP, alpha1-antitrypsin, and C3a and decrease of platelet count were recorded in both groups, but no statistically significant difference between them was recorded. However, serum concentrations of IL-8 were significantly higher in group A patients 24 hours postoperatively (p = 0.01). No significant difference was apparent in the biological response between patients receiving a polyester or an ePTFE stent graft, except for fever and serum concentrations of IL-8.
authors.affiliation: Fifth Surgical Department, Aristotle's University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gerasimidis
authors.forename: Giorgos
authors.initials: G
authors.lastname: Sfyroeras
authors.forename: Giorgos
authors.initials: G
authors.lastname: Trellopoulos
authors.forename: Lemonia
authors.initials: L
authors.lastname: Skoura
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Papazoglou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Konstantinidis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Karamanos
authors.forename: Asimina
authors.initials: A
authors.lastname: Filaktou
authors.forename: Efthimia
authors.initials: E
authors.lastname: Parapanisiou
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty / Q000009:adverse effects*; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000601:surgery*; D001772:Blood Cell Count; D015932:Complement C3c / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D017558:Elective Surgical Procedures / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011091:Polyesters; D011138:Polytetrafluoroethylene; D015607:Stents; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*
chemical_list: D000209:Acute-Phase Proteins; D016207:Cytokines; D011091:Polyesters; D015932:Complement C3c; D011138:Polytetrafluoroethylene