title: Brain mechanisms of proactive interference in working memory.
abstract: It has long been known that storage of information in working memory suffers as a function of proactive interference. Here we review the results of experiments using approaches from cognitive neuroscience to reveal a pattern of brain activity that is a signature of proactive interference. Many of these results derive from a single paradigm that requires one to resolve interference from a previous experimental trial. The importance of activation in left inferior frontal cortex is shown repeatedly using this task and other tasks. We review a number of models that might account for the behavioral and imaging findings about proactive interference, raising questions about the adequacy of these models.
authors.affiliation: Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109-1109, USA. jjonides@umich.edu
authors.forename: J
authors.initials: J
authors.lastname: Jonides
authors.forename: D E
authors.initials: DE
authors.lastname: Nee
mesh_terms: D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*