Vaginal involvement in a woman with Darier's disease: a case report.
BACKGROUND
Involvement of the female genital tract by Darier's disease, an unusual genodermatosis, is uncommon, and the manifestation of the disease in a cervicovaginal smear is exceptionally rare.


METHODS
A 39-year-old woman had an abnormal Pap smear caused by involvement of the female genital tract by Darier's disease. Cytologic examination showed features consistent with a low grade squamous intraepithelial lesion, but during a biopsy it was found to be vaginal involvement by Darier's disease.


CONCLUSIONS
The correct interpretation of cytologic findings is not possible when the diagnosis of Darier's disease is not known since a low grade squamous intraepithelial lesion cannot be ruled out. This case underlines the importance of knowing the patient's medical histoiy in any moment of medical attention.
Suárez-Peñaranda
José Manuel
JM
Department of Pathology, Clinical University Hospital of Santiago de Compostela, Spain. jsuarezp@usc.es
Antúnez
José Ramón
JR
Del Rio
Emilio
E
Vázquez
Veiga H
VH
Novo Domínguez
Alejandro
A
D017255:Acitretin / Q000627:therapeutic use; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D007644:Darier Disease / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism; D007641:Keratolytic Agents / Q000627:therapeutic use; D065006:Papanicolaou Test; D012008:Recurrence; D012867:Skin / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014621:Vagina / Q000473:pathology*; D014623:Vaginal Diseases / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology
D007641:Keratolytic Agents; D007633:Keratins; D017255:Acitretin