title: Evaluation of anthracycline-induced early left ventricular dysfunction in children with cancer: a comparative study with echocardiography and multigated radionuclide angiography.
abstract: The study aimed to compare diastolic and systolic dysfunctions detected by echocardiography (ECHO) and multigated radionuclide angiography (MUGA) in patients with cancer in the first 3 months after anthracycline-comprising chemotherapy. Children with leukemia and solid tumors who had anthracycline-comprising chemotherapy were enrolled in the study. ECHO and MUGA were performed in all patients before the first chemotherapy course and in the first 3 month of completing anthracycline-comprising chemotherapy. Cumulative anthracycline doses per body surface were calculated. Left ventricular systolic and diastolic functions were measured by both techniques. Twenty-one patients with a median age of 6.9 +/- 3.6 years were enrolled in the study. Mean cumulative anthracycline doses were equivalent to 276 +/- 83 mg/m2 doxorubicin. After anthracycline chemotherapy, cardiac dysfunction was detected in 14 and 48% of the patients by ECHO and MUGA, respectively. All dysfunctions detected by ECHO were systolic, whereas 29% of the patients had diastolic and 38% of the patients had systolic dysfunction in MUGA study. Although the study group is small, MUGA seems more sensitive in detecting anthracycline-induced systolic and diastolic cardiac dysfunctions compared to ECHO.
authors.affiliation: Department of Pediatric Oncology, Kocaeli University, Izmit-Kocaeli, Turkey. fundacorapcioglu@yahoo.com
authors.forename: Funda
authors.initials: F
authors.lastname: Corapçioglu
authors.forename: Nazan
authors.initials: N
authors.lastname: Sarper
authors.forename: Fatma
authors.initials: F
authors.lastname: Berk
authors.forename: Tayfun
authors.initials: T
authors.lastname: Sahin
authors.forename: Emine
authors.initials: E
authors.lastname: Zengin
authors.forename: Hakan
authors.initials: H
authors.lastname: Demir
mesh_terms: D000293:Adolescent; D018943:Anthracyclines / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D011875:Radionuclide Angiography; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging
chemical_list: D018943:Anthracyclines