Disc regeneration: why, when, and how.
There is increasing acknowledgment that patients with back pain who are candidates for surgery, will benefit over the long term from less invasive procedures that facilitate dynamic stabilization, rather than fusion. Dynamic stabilization can be addressed by providing assistance using mechanical devices, or relying on biologic processes such as tissue regeneration and repair. The concept of biologic disc repair has grown in recent years because of improved understanding of the cellular and molecular events of disc aging and degeneration. This article describes approaches to cell therapy, reviews relevant studies, and discusses ways to maximize clinical efficacy. Tissue engineering approaches for disc regeneration and healing have significant clinical potential.
Lotz
J C
JC
Orthopaedic Bioengineering Laboratory, University of California, San Francisco, CA 94143-0514, USA. jlotz@itsa.ucsf.edu
Kim
A J
AJ
D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D007403:Intervertebral Disc / Q000503:physiopathology*; D012038:Regeneration / Q000502:physiology*; D013122:Spinal Diseases / Q000503:physiopathology / Q000628:therapy*; D023822:Tissue Engineering