Possible role of endogenous growth inhibitors in regeneration of organs: searching for new approaches.
A hydrophilic protein component (12-17 kDa) of the thermostable protein complex (TSPC) of different organs (heart, liver, kidney, brain) of adult white rats has been identified using hydrophobic interaction chromatography (HIC). Chromatograms and spectra of the myocardial hydrophilic component of different animals (snail, pigeon, rat, pig) detected within the UV region (190-360 nm) have shown that in different organs of the same animal species as well as in the same organ (e.g. heart) of different species, TSPC contains identical hydrophilic components, i.e. there is clearly a phylogenetically conserved group of thermostable proteins that regulates proliferation processes.
Giorgobiani
N
N
Laboratory of Developmental Biology, Tbilisi State University, 1 Chavchavadze Avenue, 0108 Tbilisi, Georgia, USA. nana_giorg@yahoo.com
Dzidziguri
D
D
Rukhadze
M
M
Rusishvili
L
L
Tumanishvili
G
G
D000818:Animals; D001921:Brain / Q000378:metabolism; D002845:Chromatography; D010856:Columbidae; D006131:Growth Inhibitors / Q000502:physiology*; D057927:Hydrophobic and Hydrophilic Interactions; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012038:Regeneration; D012908:Snails; D013552:Swine
D006131:Growth Inhibitors