Buprenorphine detection in biological samples.
Buprenorphine is a narcotic analgesic used in the treatment of moderate-to-severe pain. In Italy, buprenorphine is now being used as an alternative in the therapeutic treatment of heroin abusers. Even if confirmation methods are needed for identification and quantitation, a rapid and sensitive test, such as an immunoassay, is essential for screening. We evaluated the Buprenorphine One-step ELISA test (designed for serum specimens) for the qualitative determination of buprenorphine in other matrices, such as urine, saliva and hair.
De Giovanni
Nadia
N
Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore, Rome, Italy. fortox@rm.unicatt.it
Fucci
Nadia
N
Scarlata
Salvatore
S
Donzelli
Giovanni
G
D002047:Buprenorphine / Q000032:analysis* / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D006197:Hair / Q000737:chemistry; D003932:Heroin / Q000032:analysis; D006556:Heroin Dependence / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007558:Italy; D009292:Narcotic Antagonists / Q000032:analysis* / Q000627:therapeutic use; D012015:Reference Standards; D012463:Saliva / Q000737:chemistry; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry; D015813:Substance Abuse Detection / Q000379:methods*; D014556:Urine / Q000737:chemistry
D009292:Narcotic Antagonists; D002047:Buprenorphine; D003932:Heroin