title: DNA repair mechanisms in plants: crucial sensors and effectors for the maintenance of genome integrity.
abstract: As obligate phototrophs, plants harness energy from sunlight to split water, producing oxygen and reducing power. This lifestyle exposes plants to particularly high levels of genotoxic stress that threatens genomic integrity, leading to mutation, developmental arrest and cell death. Plants, which with algae are the only photosynthetic eukaryotes, have evolved very effective pathways for DNA damage signalling and repair, and this review summarises our current understanding of these processes in the responses of plants to genotoxic stress. We also identify how the use of new and emerging technologies can complement established physiological and ecological studies to progress the application of this knowledge in biotechnology.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. cliff.bray@manchester.ac.uk
authors.forename: Clifford M
authors.initials: CM
authors.lastname: Bray
authors.forename: Christopher E
authors.initials: CE
authors.lastname: West
mesh_terms: D020137:Base Pair Mismatch; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics* / Q000528:radiation effects; D018745:Genome, Plant; D010788:Photosynthesis; D010944:Plants / Q000235:genetics*; D011995:Recombination, Genetic; D014466:Ultraviolet Rays