title: Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands.
abstract: A novel series of 5-HT(7) receptor ligands has been identified and evaluated, providing compounds showing a broad spectrum of functional activities and good selectivity over selected receptors and ion channels.
authors.affiliation: The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Harlow, Essex CM20 2QR, UK. piotr_raubo@merck.com
authors.forename: Piotr
authors.initials: P
authors.lastname: Raubo
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Beer
authors.forename: Peter A
authors.initials: PA
authors.lastname: Hunt
authors.forename: Ian T
authors.initials: IT
authors.lastname: Huscroft
authors.forename: Clare
authors.initials: C
authors.lastname: London
authors.forename: Josephine A
authors.initials: JA
authors.lastname: Stanton
authors.forename: Janusz J
authors.initials: JJ
authors.lastname: Kulagowski
mesh_terms: D000478:Alkylation; D000586:Amination; D003500:Cyclization; D008024:Ligands; D015394:Molecular Structure; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008024:Ligands; D011985:Receptors, Serotonin; D013450:Sulfones