Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression.
The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
Lam
Siew Hong
SH
Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543.
Wu
Yi Lian
YL
Vega
Vinsensius B
VB
Miller
Lance D
LD
Spitsbergen
Jan
J
Tong
Yan
Y
Zhan
Huiqing
H
Govindarajan
Kunde R
KR
Lee
Serene
S
Mathavan
Sinnakarupan
S
Murthy
Karuturi R Krishna
KR
Buhler
Donald R
DR
Liu
Edison T
ET
Gong
Zhiyuan
Z
D000595:Amino Acid Sequence; D000818:Animals; D002273:Carcinogens; D017124:Conserved Sequence; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D015027:Zebrafish / Q000235:genetics* / Q000378:metabolism*
D002273:Carcinogens; D009363:Neoplasm Proteins