Glutathione S-transferase M1 gene null genotype and gastric cancer risk in Taiwan.
OBJECTIVE
Glutathione S-transferases (GST) are involved in the detoxification of many potential carcinogens and appear to play an important role in the protection from carcinogens. The association between different GSTM1 genotypes and gastric cancer risk is still controversial. The aim of this study was to determine the association between the GSTM1-null genotype and gastric cancer risk.


METHODS
A retrospective, hospital-based case-control study of 123 primary gastric cancer patients and 121 healthy controls was conducted to evaluate the presence or absence of the GSTM1 gene from peripheral blood samples by a PCR-based method.


RESULTS
The frequency of the GSTM1-null was 59.3% in the gastric cancer group and 45.5% in the control group. An increase in risk for gastric cancer was found among carriers of GSTM1-null genotype. The odds ratio (OR) was 1.752, with 95% confidence interval (CI) = 2.963 approximately 1.035.


CONCLUSIONS
GSTM1-null polymorphism was associated with genetic susceptibility of gastric cancer in Taiwan.
Lai
Kuang-Chi
KC
Department of Surgery, China Medical University Hospital, Taichung, Taiwan.
Chen
Wen-Chi
WC
Tsai
Fuu-Jen
FJ
Li
Shuan-Yow
SY
Chou
Ming-Chih
MC
Jeng
Long-Bin
LB
D000328:Adult; D017677:Age Distribution; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D011336:Probability; D012016:Reference Values; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D018570:Risk Assessment; D017678:Sex Distribution; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000628:therapy; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology
D005982:Glutathione Transferase