Antiphospholipid syndrome and retinal vein occlusion in adults.
Antiphospholipid antibodies may play and important role in the pathogenesis of retinal vascular occlusions; investigated the prevalence among 33 patients with retinal vein and artery occlusions and 80 controls. Prevalence was 33% and 5% respectively. Ophthalmic examination and fluorescein angiography showed that occlusions were due to ischaemic events. The 11 patients were diagnosed with antiphospholipid syndrome: 9 patients were treated successfully with laser photocoagulation and anticoagulant and anti-aggregant therapy. Two patients with antiphospholipid antibodies associated with resistance to activated protein C had unfavourable outcomes. Our results suggest a correlation between antiphospholipid syndrome and retinal vein occlusions; we recommend a systematic search for antiphospholipid antibodies in occlusions of unexplained origin and laser photocoagulation treatment and long-term oral anticoagulant and anti-aggregant therapy.
Maaroufi
R M
RM
Higher Institute of Biotechnology, Monastir, Tunisia.
Hamdi
R
R
Jmili
N
N
Ghorbal
M
M
Hamida
Bel Hadj F
BH
Mahjoub
T
T
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000097:blood; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009887:Ophthalmoscopy; D015995:Prevalence; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014416:Tunisia / Q000453:epidemiology
D017152:Antibodies, Antiphospholipid; D000925:Anticoagulants