A case with cholinesterase inhibitor responsive asymmetric posterior cortical atrophy.
A 55-year-old right-handed woman presented initially with mild amnestic and depressive episodes but slowly developed progressive neurobehavioral symptoms, indicative of posterior cortical atrophy in ensuing years. A more detailed neurobehavioral test suggested predominant right temporo-parietal dysfunction with executive functional deficits. SPECT and MRI findings revealed right unilateral temporo-parietal involvement. Cholinesterase inhibitor administration led to amelioration of symptoms. We suggest that cases of posterior cortical atrophy or visual variant of Alzheimer's disease may be responsive to cholinesterase inhibitor therapy; however, the observation in a single case should be confirmed on larger populations in a clinical trial design with placebo control.
Kim
Eunhee
E
Department of Neurology, Chungbuk National University Hospital, Republic of Korea.
Lee
Yunsoo
Y
Lee
Jongkeol
J
Han
Seol-Heui
SH
D001072:Apraxias / Q000209:etiology; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003704:Dementia / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D005260:Female; D005702:Galantamine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010468:Perceptual Disorders / Q000209:etiology
D002800:Cholinesterase Inhibitors; D005702:Galantamine