title: The influence of underweight and dietary support on well-being in lung transplant candidates.
abstract: BACKGROUND
  Quality of life has been found to be a significant predictor of survival in lung transplantation candidates. The aim of this study was to investigate associations between underweight, dietary support and well-being.
  
  
  METHODS
  A self-administered questionnaire for perceived well-being was administered to underweight (n=42) and normal-weight (n=29) candidates for lung transplantation before and after dietary intervention in which the underweight patients received dietary support for weight gain.
  
  
  RESULTS
  Underweight compared with normal-weight, independent of lung function, was associated with low well-being in several of the measured dimensions. Improvements were observed after dietary intervention compared with baseline in the underweight patients, for scores in the dimension of tiredness 29.2 (4.2) vs. 26.2 (6.0), P<0.01; general satisfaction 4.7 (1.5) vs. 4.0 (1.4), P=0.01; social life 16.7 (3.9) vs. 15.0 (4.4), P=0.02) (mean (sd) before and after dietary intervention respectively), but not in the normal-weight patients. The underweight patients achieved the goal for energy intake and protein intake and experienced a significant weight gain. Regression analyses showed that none of the well-being improvements was associated with weight gain or change in body composition. However, an association between less tiredness and an increase in protein intake was indicated (b=-0.305, P=0.055).
  
  
  CONCLUSIONS
  Underweight compared with normal-weight was associated with more impaired quality of life in candidates for lung transplantation and some benefit from dietary support in terms of well-being was indicated.
authors.affiliation: Department of Thoracic Medicine, Rikshospitalet, Oslo, Norway; Medical Department, Rikshospitalet, Oslo, Norway. liv.forli@rikshospitalet.no
authors.forename: Liv
authors.initials: L
authors.lastname: Førli
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Moum
authors.forename: Oystein
authors.initials: O
authors.lastname: Bjørtuft
authors.forename: Morten
authors.initials: M
authors.lastname: Vatn
authors.forename: Jacob
authors.initials: J
authors.lastname: Boe
mesh_terms: D000328:Adult; D000886:Anthropometry; D003430:Cross-Sectional Studies; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005221:Fatigue / Q000150:complications / Q000178:diet therapy; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011594:Psychometrics; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000601:surgery; D011788:Quality of Life; D013851:Thinness / Q000150:complications / Q000178:diet therapy*; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D004044:Dietary Proteins