title: Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse.
abstract: B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and mouse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation. In addition, the mechanisms triggering pre-BCR activation are reviewed, taking into account the recent report of heparan sulfates and galectin 1 as stromal cell-derived pre-BCR ligands. Finally, ligand-induced pre-BCR activation models are proposed on the bases of the differences reported for pre-BCR and IL7 dependencies in the two species.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), CNRS-INSERM-University Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Espeli
authors.forename: Benjamin
authors.initials: B
authors.lastname: Rossi
authors.forename: Stéphane J C
authors.initials: SJ
authors.lastname: Mancini
authors.forename: Philippe
authors.initials: P
authors.lastname: Roche
authors.forename: Laurent
authors.initials: L
authors.lastname: Gauthier
authors.forename: Claudine
authors.initials: C
authors.lastname: Schiff
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D054420:Pre-B Cell Receptors; D011947:Receptors, Antigen, B-Cell; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D008562:Membrane Glycoproteins; D054420:Pre-B Cell Receptors; D011947:Receptors, Antigen, B-Cell