title: Anti-inflammatory activity of Croton cuneatus aqueous extract.
abstract: The aqueous extract of Croton cuneatus Klotz. (Euphorbiaceae), was tested for its antinociceptive effects using chemical and thermal test models in mice. Anti-inflammatory activity was determined in Sprague-Dawley rats in a model of acute plantar inflammation induced by bovine serum albumin. Croton cuneatus aqueous extract at doses of 7 mg/kg showed a significant anti-inflammatory effect compared with commonly used non-stereoidal drugs as ketoprofen, sodium diclofenac and ASA (acetylsalicylic acid).
authors.affiliation: Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40109, Caracas, Venezuela. asuarez@strix.ciens.ucv.ve
authors.forename: Alírica I
authors.initials: AI
authors.lastname: Suárez
authors.forename: Zuleyma
authors.initials: Z
authors.lastname: Blanco
authors.forename: Reinaldo S
authors.initials: RS
authors.lastname: Compagnone
authors.forename: María M
authors.initials: MM
authors.lastname: Salazar-Bookaman
authors.forename: Varlin
authors.initials: V
authors.lastname: Zapata
authors.forename: Claudia
authors.initials: C
authors.lastname: Alvarado
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D029802:Croton / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts