[Cellular calcium ion signalling--from basic research to benefits for patients].
A large number of ion channels, enzymes, pumps and binding proteins participate in the generation of intracellular Ca2+ signals and their decoding. Ca2+ signalling takes place in the form of oscillations, waves and sparks. Such Ca2+ signals occur in almost all cells and regulate diverse cell functions. Perturbation of Ca2+ signalling leads to disease states. Drugs that act on Ca2+-signalling are commonly used in treatment of several diseases. Different molecules involved in Ca2+ signalling are potential targets for development of new therapies. Thus, basic research in Ca2+ signalling increases our understanding of the pathogenesis of diseases at a molecular level and the likelihood of development of new therapeutic modalities.
Gustafsson
Amanda Jabin
AJ
Södersjukhuset, Forskningscentrum, Karolinska institutet, Stockholm. amajab@ki.se
Islam
Md Shahidul
MS
D002121:Calcium Channel Blockers / Q000627:therapeutic use; D015220:Calcium Channels / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D020013:Calcium Signaling / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D022082:Cellular Structures / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D006801:Humans; D009154:Mutation; D015398:Signal Transduction / Q000502:physiology
D002121:Calcium Channel Blockers; D015220:Calcium Channels