title: Effects of single herbal drugs on adhesion and migration of melanocytes.
abstract: OBJECTIVE
  To find herbs with effects on adhesion and migration of melanocytes in vitro.
  
  
  METHODS
  Ethanol extracts from 14 herbs were tested. Normal human melanocytes were obtained from neonatal foreskin, and the 48-well culture dish covered with fibronectin was used for the melanocyte adhesion assay. Motility was assessed by using the micropore filter method.
  
  
  RESULTS
  The extracts of Danshen (Radix Salviae Miltiorrhizae), Tusizi (Semen Cuscutae) and Honghua (Flos Carthami) could enhance melanocyte adhesion to fibronectin, while Cijili (Fructus Tribuli) and Huangqi (Radix Astragali) promote melanocyte migration in vitro. Buguzhi (Fructus Psoraleae), Nü Zhen Zi (Fructus Ligustri Lucidi) and Baizhi (Radix Angelicae Dahuricae) could promote both adhesion and migration of melanocytes.
  
  
  CONCLUSIONS
  The above herbs may play a role through promoting adhesion and/or migration of melanocytes in the treatment of vitiligo.
authors.affiliation: Department of Dermatology, Second Hospital, Xi'an Jiaotong University, Shaanxi 710004, China.
authors.forename: Xianqi
authors.initials: X
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.forename: Kuanhou
authors.initials: K
authors.lastname: Mu
authors.forename: Huiqun
authors.initials: H
authors.lastname: Ma
authors.forename: Xinwu
authors.initials: X
authors.lastname: Niu
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Qianli
authors.initials: Q
authors.lastname: Dang
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008544:Melanocytes / Q000166:cytology*; D012867:Skin / Q000166:cytology; D014820:Vitiligo / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal