[TPA increases cell proliferation of HEp-2 cell line in vitro].
OBJECTIVE
To investigate the influence of TPA treatment on HEp-2 cell line in vitro.


METHODS
HEp-2 cell line cultured in vitro was treated by different concentration levels of TPA. MTT method was used to detect survival cell ratio of HEp-2.


RESULTS
Cell growth of HEp-2 after treatment of TPA manifested an peak. The highest peak which was 1.3 to 1.4 times of control cell presented on 10 microg/L concentration level. Cell proliferation ability dropped gradually following increase of TPA concentration.


CONCLUSIONS
TPA can increase cell proliferation of HEp-2 cell in vitro.
Liu
Weiwei
W
Cancer Center of Sun Yat-Sen University, Guangzhou 510060, China. drliuwei@163.com
Zeng
Zongyuan
Z
Xiao
Xibin
X
D002273:Carcinogens / Q000633:toxicity; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D002273:Carcinogens; D013755:Tetradecanoylphorbol Acetate