[An interesting change of E-selectin in cimetidine administration during anticancer drug use].
E-selectin is an adhesion molecule developed as an important material for hematogenous metastasis of cancer cells on vascular endothelial cells. It is expected that if we can restrain a manifestation of E-selectin then hematogenous metastasis can be restrained. We divided gastric cancer and the colorectal cancer patients, who performed chemotherapy, into two groups of cimetidine administrated group and a non-administration group, and reviewed whether cimetidine inhibited an expression of E-selectin on vascular endothelial cells by measuring E-selectin in plasma. We experienced one example that showed an interesting change of E-selectin and the quantity of E-selectin in plasma fell during the cimetidine dosage. However, we report that E-selectin has risen after the cimetidine dosage was cancelled in the cimetidine administrated group.
Kawase
Jin
J
Dept. of Surgery, 2nd Teaching Hospital, Fujita Health University.
Kobayashi
Kenichi
K
Imaeda
Yoshihiro
Y
Umemoto
Syunji
S
Matsumoto
Sumio
S
D002927:Cimetidine / Q000494:pharmacology* / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D019040:E-Selectin / Q000032:analysis* / Q000097:blood; D042783:Endothelial Cells / Q000737:chemistry; D006801:Humans; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy*
D019040:E-Selectin; D002927:Cimetidine