title: [Change rate in bone cells of mice].
abstract: OBJECTIVE
  To study the anti-mutation action of acupuncture and moxibustion.
  
  
  METHODS
  Mice were randomly divided into 6 groups, group 1 (normal control group), group 2 (positive control group), group 3 (prevention group I), group 4 (prevention group II ), group 5 (treatment group I) and group 6 (treatment group II). The mice in the group 2-6 were treated by cyclophosphamide (ip, 50 mg/kg body weight), and in the 3'-6 groups were given acupuncture at "Zusanli" (ST 36) and moxibustion at "Guanyuan" (CV 4). At the end of experiment, all the mice were decapitated and chromosome aberration rate and sister chromatid exchange rate of bone marrow cells were investigated.
  
  
  RESULTS
  The chromosome aberration rate and the sister chromatid exchange rate of bone marrow cells in the positive control group increased significantly as compared with the normal control group, while they decreased significantly in the group 3, 4, 5, 6 as compared with the positive control group (P < 0.01).
  
  
  CONCLUSIONS
  Acupuncture and moxibustion have anti-mutation action, inhibiting the increase of chromosome aberrations and sister chromatid exchange of bone marrow cells in mice induced by cyclophosphamide.
authors.affiliation: Zhangjiakou Medical College, Hebei 075029, China. ztt4321@163.com
authors.forename: Shi-min
authors.initials: SM
authors.lastname: Zhang
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Wei
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Yang
authors.forename: Cui-shi
authors.initials: CS
authors.lastname: Tian
authors.forename: Ji-hong
authors.initials: JH
authors.lastname: Li
mesh_terms: D015670:Acupuncture Therapy; D000818:Animals; D003520:Cyclophosphamide; D051379:Mice; D009071:Moxibustion
chemical_list: D003520:Cyclophosphamide