title: [Irinotecan in combination with 5-fluorouracil and leucovorin in the treatment of metastatic colorectal cancer].
abstract: BACKGROUND
  Introducing irinotecan and oxaliplatin in to the treatment of advanced colorectal cancer substantially improved the therapeutic results for this malignancy. The first results of clinical trials with these two drugs were published in 2000.
  
  
  RESULTS
  Between 1999 to 2004 we treated 51 patients with the combination of irinotecan 180mg/m2 on day 1 and two hour infusion of leucovorin 200mg/m2 and 5-FU push of 400mg/m2 followed by infusion of 5- FU for 22 hours on days 1 and 2 every 2 weeks. Six patients (11.7%) achieved complete response, 11 (21.57%) partial response, stabilisation was observed by 23 patients (45.1%) and 21 patients were progressive (21.5%). The median survival time was 18 months (95% CI, 16.93-19.7), median duration of response was 9 months (Cl 95% 8.25-11.5).
  
  
  CONCLUSIONS
  The combination of FOLFIRI is an effective and tolerable treatment of advanced colorectal cancer. However new treatment modalities to improve further the results of the treatment are still warranted.
authors.affiliation: Radioterapeuticko-onkologické oddĕlení 2. LF UK a FNM, Praha. jana.prausova@lfmotol.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Prausová
authors.forename: K
authors.initials: K
authors.lastname: Kubácková
authors.forename: Z
authors.initials: Z
authors.lastname: Linke
authors.forename: E
authors.initials: E
authors.lastname: Kubala
authors.forename: R
authors.initials: R
authors.lastname: Pipková
authors.forename: J
authors.initials: J
authors.lastname: Hladíková
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin