title: Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury.
abstract: The single exhalation analysis of carbon monoxide, acetylene, and methane allows the determination of intrabreath (regional) DL, pulmonary capillary blood flow and ventilation inhomogeneities during rest and exercise. We reasoned that this technique might be more sensitive in detecting regional pulmonary capillary abnormalities than resting single breath DL (DL(sb)). We selected a group of breast cancer patients in high-dose chemotherapy (HDCT) protocols who were at risk for pulmonary injury. We grouped the patients into pre-HDCT and post-HDCT, and used resting DL(sb) to further categorize the latter into those with and without pulmonary injury. We found that exercise DL increases were blunted in post-HDCT patients with low resting DL(sb). More importantly, even in post-HDCT patients with normal resting DL(sb), exercise DL response was reduced in the slowest emptying lung units along with evidence for ventilation inhomogeneities (increased methane slope). We conclude that exercise assessments of DL at low lung volumes and gas mixing properties may be sensitive indicators of lung injury.
authors.affiliation: Human Studies Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA. huang.tony@epa.gov
authors.forename: Yuh-Chin T
authors.initials: YC
authors.lastname: Huang
authors.forename: Sharon R
authors.initials: SR
authors.lastname: O'brien
authors.forename: James
authors.initials: J
authors.lastname: Vredenburgh
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Folz
authors.forename: Neil R
authors.initials: NR
authors.lastname: Macintyre
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy; D001944:Breath Tests / Q000379:methods*; D002196:Capillaries / Q000503:physiopathology; D002248:Carbon Monoxide; D005080:Exercise Test / Q000379:methods; D005260:Female; D006339:Heart Rate; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation; D011653:Pulmonary Diffusing Capacity
chemical_list: D000970:Antineoplastic Agents; D002248:Carbon Monoxide; D010100:Oxygen