Topical antiinflammatory and analgesic activities of Copaifera duckei dwyer.
The oleoresin of several Copaifera species is used widely in the Amazonian Region mainly as a topical antiinflammatory and healing agent. The topical analgesic and antiinflammatory activities of Copaifera duckei oleoresin, whose terpenoidal chemical composition has been characterized, are now examined. Antiinflammatory activity was evaluated in rats using the carrageenin-induced paw edema and the granuloma tests, and in mice by the croton oil-induced dermatitis test. Analgesic activity was determined in mice using the writhing test method. In the carrageenin-induced edema and granuloma tests the oleoresin in a dose of 1,802 mg/kg inhibited the edema by 18% and granuloma by 42% (p < 0.05), this last result similar to that observed with dexamethasone. Topical doses of 517 mg/kg, 1,035 mg/kg and 1,802 mg/kg produced 52%, 58% and 62% (p < 0.05) reduction of the edema induced by croton oil, respectively, and 48%, 56% and 65% inhibition of the writhing process (p < 0.05). These results suggest that the Copaifera duckei oleoresin has topical antiinflammatory and analgesic activities.
Carvalho
J C T
JC
Centro de Ciências Biológicas E Da Saúde, Universidade Federal do Amapá, Campus Universitário, Marco Zero do Equador, Rod. Juscelino Kubitschek de Oliveira, km -02, Bairro Zerão, CEP 68.902-280, Macapá, AP, Brazil. Farmacos@unifap.br
Cascon
V
V
Possebon
L S
LS
Morimoto
M S S
MS
Cardoso
L G V
LG
Kaplan
M A C
MA
Gilbert
B
B
D000279:Administration, Cutaneous; D000700:Analgesics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003436:Croton Oil; D003872:Dermatitis / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D007887:Fabaceae; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000032:analysis
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013729:Terpenes; C018620:oleoresins; D003436:Croton Oil