HIV-1-induced depletion of CD4+ T cells in the gut: mechanism and therapeutic implications.
The mechanism of CD4+ T cell depletion remains a central unresolved issue in AIDS research. Recent studies have examined the massive depletion of CD4+ T cells observed in macaque models of acute HIV infection. A key question is whether the observed CD4+ T cell death is due to direct consequences of viral infection and to indirect mechanisms including increased expression of mediators of T-cell apoptosis. The therapeutic implications of the early CD4+ T cell loss are discussed.
Chase
Amanda
A
Department of Medicine, Johns Hopkins University School of Medicine and Howard Hughes Medical Institute, 733 N. Broadway, Baltimore MD 21205, USA.
Zhou
Yan
Y
Siliciano
Robert F
RF
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D007422:Intestines / Q000276:immunology* / Q000473:pathology