title: The role of ultrasound biomicroscopy in predicting the result of temporal artery biopsy in temporal arteritis patients: a preliminary study.
abstract: OBJECTIVE
  Temporal artery biopsy is considered the gold standard for the diagnosis of temporal arteritis (TA). However, complications following this procedure may occur. The goal of this study is to evaluate if ultrasound biomicroscope (UBM) findings are useful in predicting the result (positive or negative) of temporal artery biopsy in patients with TA.
  
  
  METHODS
  Twenty-six consecutive patients with clinical diagnosis of TA seen at the Department of Ophthalmology, Royal Victoria Hospital, Montreal, Canada, were involved in this study. All patients were submitted to UBM before temporal artery biopsy. Eight patients presented histopathologic findings consistent with the diagnosis of TA. Thus, UBM findings of these patients were compared with those from 18 patients with negative biopsy. On UBM we searched for the presence of a hypoechoic effect surrounding the walls of the temporal arteries, the so-called halo sign, as well as an intra-arterial middle reflexive filling, the so-called intra-arterial filling.
  
  
  RESULTS
  The halo sign and/or the intra-arterial filling were found in 8 (100%) of 8 patients with biopsy-proven TA. However, 10 (55.5%) of 18 patients with a negative biopsy presented one or both of these two UBM findings. On the other hand, the absence of these two parameters on the UBM of a patient with TA strongly suggests that the temporal artery biopsy will be negative (negative predictive value=100%).
  
  
  CONCLUSIONS
  This preliminary work suggests that UBM may play a role in predicting a negative result of the temporal artery biopsy in patients with TA. In the present series approximately 30% of the patients could be spared this surgical procedure and its possible complications.
authors.affiliation: Uveitis and Ocular Immunology Unit and Ultrasound Diagnostic Center, Department of Ophthalmology, Royal Victoria Hospital, Montreal, Quebec, Canada. raulngvianna@ig.com.br
authors.forename: R N G
authors.initials: RN
authors.lastname: Vianna
authors.forename: M
authors.initials: M
authors.lastname: Mansour
authors.forename: P C
authors.initials: PC
authors.lastname: Ozdal
authors.forename: J Pessoa
authors.initials: JP
authors.lastname: Souza Filho
authors.forename: S
authors.initials: S
authors.lastname: Bakalian
authors.forename: V S
authors.initials: VS
authors.lastname: Saraiva
authors.forename: J
authors.initials: J
authors.lastname: Deschenes
authors.forename: M N
authors.initials: MN
authors.lastname: Burnier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005189:False Positive Reactions; D005260:Female; D013700:Giant Cell Arteritis / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D033401:Microscopy, Acoustic / Q000379:methods*; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013699:Temporal Arteries / Q000000981:diagnostic imaging* / Q000473:pathology