title: Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model.
abstract: The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form III > Form I > dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed.
authors.affiliation: Pfizer Corporation, Michigan Pharmaceutical Sciences, 7000 Portage Road, Kalamazoo, 49001, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Carino
authors.forename: David C
authors.initials: DC
authors.lastname: Sperry
authors.forename: Michael
authors.initials: M
authors.lastname: Hawley
mesh_terms: D000818:Animals; D001682:Biological Availability; D002220:Carbamazepine / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D003460:Crystallization; D004285:Dogs; D004386:Duodenum / Q000378:metabolism; D005215:Fasting; D005753:Gastric Mucosa / Q000378:metabolism; D008954:Models, Biological; D012995:Solubility
chemical_list: D002220:Carbamazepine