title: ABCA1 polymorphisms and prognosis after myocardial infarction in young patients.
abstract: High-density cholesterol (HDL) levels are affected by genetic influences and certain behaviors. Low levels of HDL-C are considered as an independent risk factor for premature coronary heart disease. In patients with Tangier disease, characterised by low HDL levels, mutations in the ATP binding cassette transporter have been described. We have analysed three polymorphisms of the ABCA1 gene (-477C/T, R219 K, and I883M) in a cohort of young male survivors of myocardial infarction in order to know their influence in long-term prognosis. In premature heart disease, knowing prognosis factors is specially relevant.
authors.forename: María
authors.initials: M
authors.lastname: Martín
authors.forename: Pelayo
authors.initials: P
authors.lastname: González
authors.forename: J J R
authors.initials: JJ
authors.lastname: Reguero
authors.forename: Alberto
authors.initials: A
authors.lastname: Batalla
authors.forename: Mónica
authors.initials: M
authors.lastname: García Castro
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: César
authors.initials: C
authors.lastname: Morís
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D015331:Cohort Studies; D005500:Follow-Up Studies; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D011110:Polymorphism, Genetic; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters