Antimicrobial properties of highly fluorinated silver(I) tris(pyrazolyl)borates.
Highly fluorinated tris(pyrazolyl)borate ligand [HB(3,5-(CF3)2Pz)3]- has been used in the isolation of air- and light-stable silver complex, [HB(3,5-(CF3)2Pz)3]Ag(OSMe2). It is a monomeric tetrahedral silver complex with an O-bonded dimethylsulfoxide ligand. The silver adduct [HB(3,5-(CF3)2Pz)3]Ag(OSMe2) and the related [HB(3,5-(CF3)2Pz)3] Ag(THF) (where OSMe2 = dimethyl sulfoxide; THF = tetrahydrofuran) show good antibacterial activity, and their antimicrobial efficacy against Staphylococcus aureus is greater than those of AgNO3 and silver sulfadiazine.
Dias
H V Rasika
HV
Department of Chemistry and Biochemistry, The University of Texas at Arlington, P.O. Box 19065, Arlington, TX 76019, USA. dias@uta.edu
Batdorf
Keith H
KH
Fianchini
Mauro
M
Diyabalanage
Himashinie V K
HV
Carnahan
Sean
S
Mulcahy
Ryan
R
Rabiee
Amir
A
Nelson
Kevin
K
van Waasbergen
Lorraine G
LG
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001881:Borates / Q000737:chemistry* / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology
D000890:Anti-Infective Agents; D001881:Borates; D005663:Furans; D009942:Organometallic Compounds; D012834:Silver; C018674:tetrahydrofuran; D004121:Dimethyl Sulfoxide