Current practice of Gleason grading of prostate carcinoma.
The Gleason grading system remains one of the most powerful prognostic factors in prostate cancer and is the dominant method around the world in daily practice. It is based solely on the glandular architecture performed at low magnification. The Gleason grading system should be performed in needle core biopsies and radical prostatectomy specimens where it shows a reasonable degree of correlation between both specimens, and most importantly, it remains vital in the treatment decision-making process. This review summarizes the current status of Gleason grading in prostate cancer, incorporating recent proposals for the best contemporary practice of prostate cancer grading.
Lopez-Beltran
Antonio
A
Department of Pathology, Faculty of Medicine, Reina Sofia University Hospital and Cordoba University Medical School, Avda. Menendez Pidal s/n, 14004 Cordoba, Spain. em1lobea@uco.es
Mikuz
Gregor
G
Luque
Rafael J
RJ
Mazzucchelli
Roberta
R
Montironi
Rodolfo
R
D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000145:classification / Q000175:diagnosis*; D012720:Severity of Illness Index