title: [Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound].
abstract: OBJECTIVE
  To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT.
  
  
  METHODS
  Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum.
  
  
  RESULTS
  Inclusion ratio of CT versus HPCD was 1:1. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug.
  
  
  CONCLUSIONS
  Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yet-sen University, Guangzhou 510080, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Luo
authors.forename: Yue-hong
authors.initials: YH
authors.lastname: Xu
authors.forename: Bao
authors.initials: B
authors.lastname: Chen
authors.forename: Lian-quan
authors.initials: LQ
authors.lastname: Gu
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.forename: Pei-qing
authors.initials: PQ
authors.lastname: Liu
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D001682:Biological Availability; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C037886:cryptotanshinone