Deep brain stimulation of the internal pallidum in multiple system atrophy.
We describe the outcome of deep brain stimulation of the internal pallidum in a 57-year old patient with multiple system atrophy. Although the prominent dystonic features of this patient were markedly attenuated post-operatively, the outcome was to be considered unfavourable. There was a severe increase in akinesia resulting in overall decrease of mobility in limbs as well as in the face. As a result, the patient was anarthric and displayed dysphagia. A laterality effect of stimulation on oro-facial movements was demonstrated. The patient died 7 months post-operatively. This report adds to the growing consensus that multiple system atrophy patients are unsuitable candidates for deep brain stimulation.
Santens
Patrick
P
Department of Neurology, Gent University Hospital, Belgium. patrick.santens@ugent.be
Patrick
Santens
S
Vonck
Kristl
K
Kristl
Vonck
V
De Letter
Miet
M
Miet
De Letter
DL
Van Driessche
Katya
K
Katya
Van Driessche
VD
Sieben
Anne
A
Anne
Sieben
S
De Reuck
Jacques
J
Jacques
De Reuck
DR
Van Roost
Dirk
D
Dirk
Van Roost
VR
Boon
Paul
P
Paul
Boon
B
D046690:Deep Brain Stimulation; D004421:Dystonia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*