Homeostasis of the memory T cell pool.
Memory T cells are critical for the establishment of long-term immunity. The number of memory T cells formed at the conclusion of the primary response is strongly influenced by the number of effector T cells generated in the response, but some factors can additionally enhance the efficiency and quality of memory cell recruitment. Homeostasis of the memory T cell pool depends on cytokine-mediated regulation of cell survival and proliferation. This review discusses factors that influence both the development and the maintenance of the memory T cell pool.
Marsden
Vanessa S
VS
Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO, USA.
Kappler
John W
JW
Marrack
Philippa C
PC
D000818:Animals; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D019409:Interleukin-15 / Q000276:immunology; D019891:Leukopoiesis; D020395:Receptors, Interleukin-7 / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D019409:Interleukin-15; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain