Reconsolidation of a context long-term memory in the terrestrial snail requires protein synthesis.
We investigated the influence of the protein synthesis blocker anisomycin on contextual memory in the terrestrial snail Helix. Prior to the training session, the behavioral responses in two contexts were similar. Two days after a session of electric shocks (5 d) in one context only, the context conditioning was observed as the significant difference of behavioral response amplitudes in two contexts. On the day following testing of context learning, a session of "reminding" was performed, immediately after which the snails were injected with anisomycin or vehicle. Testing of long-term context memory has shown that only anisomycin injections impaired the context conditioning. In control series, the snails were injected after the training session with anisomycin/saline without reminding, and no impairment of the long-term context memory was observed, while injection of anisomycin during the training session completely abolished the long-term memory. No effects of anisomycin on the short-term memory were observed. Surprisingly, injection of anisomycin after the reminding combined with reinforcing stimuli elicited no effect on the context memory. Differences between single-trial and multisession learning are discussed.
Gainutdinova
Tatiana H
TH
Kazan Physical Technical Institute of Russian Academy of Sciences, Russia.
Tagirova
Rosa R
RR
Ismailova
Asja I
AI
Muranova
Lyudmila N
LN
Samarova
Elena I
EI
Gainutdinov
Khalil L
KL
Balaban
Pavel M
PM
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D004777:Environment; D006372:Helix, Snails / Q000187:drug effects / Q000378:metabolism*; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology
D011500:Protein Synthesis Inhibitors; D000841:Anisomycin