title: Diagnostic problems concerning epithelioid sarcoma--case analysis.
abstract: We discuss here five cases of epithelioid sarcoma (ES) with final diagnosis established after reexamination of initial findings. Problems with differential diagnosis of these neoplasms arise since their microscopic picture may simulate several other pathological conditions such as non-neoplastic granulomatous reactions, squamous cell carcinomas and adenocarcinomas, melanomas and soft tissue sarcomas with epithelioid component. Final ES diagnosis requires presence of cytokeratin, EMA and vimentin in neoplastic cells, as confirmed by immunohistochemical reactions. Differential diagnosis is also helped by concurrent cytology assessment that allows recognizing more easily such characteristic features as presence of plasmacytoid or spindle-shaped cells.
authors.affiliation: Department of Tumor Pathology, Center of Oncology, Maria Skłodowska-Curie Memorial Institute, Gliwice Branch. fibros@poczta.wp.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Maksymiuk
authors.forename: Anna
authors.initials: A
authors.lastname: Smok-Ragankiewicz
authors.forename: Mirosław
authors.initials: M
authors.lastname: Snietura
authors.forename: Dariusz
authors.initials: D
authors.lastname: Lange
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Słomian
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D008545:Melanoma / Q000473:pathology; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins