eIF3: a connecTOR of S6K1 to the translation preinitiation complex.
In the November 18 issue of Cell, discover an unidentified function for the eIF3 translation initiation factor as a scaffold for the dynamic associations of many preinitiation complex components, including the growth-regulating kinases mTOR and S6K1.
Peterson
Tim R
TR
The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Sabatini
David M
DM
D000818:Animals; D039621:Eukaryotic Initiation Factor-3 / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000737:chemistry / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases
D039621:Eukaryotic Initiation Factor-3; D011494:Protein Kinases; D038762:Ribosomal Protein S6 Kinases, 70-kDa; D058570:TOR Serine-Threonine Kinases