Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection.
HIV infection is associated with B cell dysfunction, which includes B cell hyperactivation, hypergammaglobulinemia, impaired production of antibodies against specific antigens, and a loss of B cell memory. Because lymph node architecture is progressively destroyed during HIV infection, it is possible that normal B cell trafficking is impaired as well, which could be a cause or a result of these abnormalities. Because the homeostatic chemokine, CXCL13 (BLC, BCA-1), is a major regulator of B cell trafficking, we assessed circulating levels of this molecule in HIV infection. Serum levels of CXCL13 were seen to be progressively elevated in HIV disease. Serum levels of CXCL13 correlated strongly with those of the inflammation-associated chemokine, inducible protein-10 (IP-10), in subjects who had advanced HIV disease, and more moderately with levels of soluble CD30 (sCD30), sCD27, and sCD23. CXCL13 levels also correlated moderately with viral load and showed a significant decline after use of highly active antiretroviral treatment (HAART). Elevated levels of CXCL13 could cause impaired or altered trafficking of B cells during HIV infection and could contribute to the previously reported loss of CXCR5, the receptor for CXCL13, from the surface of circulating B cells in HIV infection.
Widney
Daniel P
DP
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 27-139 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095-1740, USA.
Breen
Elizabeth C
EC
Boscardin
W John
WJ
Kitchen
Scott G
SG
Alcantar
Juan M
JM
Smith
Jeffrey B
JB
Zack
Jerome A
JA
Detels
Roger
R
Martínez-Maza
Otoniel
O
D023241:Antiretroviral Therapy, Highly Active; D001402:B-Lymphocytes / Q000378:metabolism / Q000821:virology; D002460:Cell Line; D002465:Cell Movement; D054382:Chemokine CXCL13; D019743:Chemokines, CXC / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D015967:Gene Expression Regulation, Viral; D015483:HIV Antibodies; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D007249:Inflammation; D017730:Ki-1 Antigen / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008198:Lymph Nodes / Q000821:virology; D008297:Male; D017455:Receptors, IgE / Q000096:biosynthesis; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000096:biosynthesis; D019562:Viral Load
C110663:CXCL13 protein, human; D054382:Chemokine CXCL13; D019743:Chemokines, CXC; D015483:HIV Antibodies; D017730:Ki-1 Antigen; D017455:Receptors, IgE; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7