title: Motor protein diseases of the nervous system.
abstract: Motor proteins link concepts of impaired axonal transport with concepts of impaired energy metabolism in motor neuron disease. Thus it is not surprising that in recent years several reports on the relevance of motor protein function in mice models for motor neuron disease as well as motor neuron patients have appeared. This article summarizes the broad spectrum of neurological phenotypes, which are caused by alterations of motor protein function. This is likely to add to the understanding of motor neuron disease and may be relevant in terms of future therapeutic approaches.
authors.affiliation: Department of Neurology, University of Ulm, Germany. oliver.haneman@medizine.uni-ulm.de
authors.forename: C Oliver
authors.initials: CO
authors.lastname: Hanemann
authors.forename: Albert C
authors.initials: AC
authors.lastname: Ludolph
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D020409:Molecular Motor Proteins / Q000235:genetics / Q000378:metabolism; D016472:Motor Neuron Disease / Q000473:pathology / Q000503:physiopathology*; D017933:Peripheral Nervous System / Q000502:physiology*; D010641:Phenotype
chemical_list: D003598:Cytoskeletal Proteins; D020409:Molecular Motor Proteins