title: Leprosy in Malaysia.
abstract: Leprosy is a chronic infectious disease and is still a public health problem in Malaysia. In 1926, the Leper Enactment Act was established which required compulsory notification and isolation of leprosy patients. As a result, the National Leprosy Control Centre (NLCC) was built in Sungai Buloh, Selangor. In 1969, the National Leprosy Control programme was launched with the objective of early case finding and decentralisation of treatment of leprosy. The treatment of leprosy patients is integrated with basic Medical and Health services in Malaysia. With the implementation of multiple drug therapy in 1985, the National prevalence rate of leprosy has reduced from 5.7 per 10,000 in 1983 to 1.7 per 10,000 in 1992. The Research Unit in NLCC was established in 1950, where cultivation of Mycobacterium leprae using mouse foot-pad technique is done. This technique is used for assessment of efficacy of chemotherapeutic agents in leprosy. Research activites are also done in collaboration with the Institute for Medical Research in Kuala Lumpur such as isolation of Mycobacterium leprae antigen using T cell clones and phenolic glycolipid antigen.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Malaya, 59100 Kuala Lumpur, Malaysia.
authors.forename: P
authors.initials: P
authors.lastname: Jayalakshmi
mesh_terms: D000818:Animals; D042241:Early Diagnosis; D005528:Foot / Q000382:microbiology; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D008296:Malaysia / Q000453:epidemiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D009166:Mycobacterium leprae / Q000187:drug effects / Q000254:growth & development; D015995:Prevalence; D011634:Public Health / Q000331:legislation & jurisprudence*
chemical_list: D007917:Leprostatic Agents