Elevated levels of serum perforin in chronic HIV-1 and acute SIV/SHIV infection.
The impaired functional activity of cytotoxic T lymphocytes and natural killer cells during HIV-1 infection has recently been attributed to decreased intracellular levels of perforin and granzyme B. In sera from individuals chronically infected with HIV-1 we report increased levels of extracellular perforin compared with uninfected individuals. Increased perforin was also observed during experimental SIV/SHIV infection. The combination of reduced intracellular perforin levels and an increased serum level indicates that HIV infection induces aberrant perforin secretion.
Klingström
Jonas
J
Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden.
Gudmundsdotter
Lindvi
L
Zuber
Bartek
B
Hinkula
Jorma
J
Mörner
Andreas
A
Wahren
Britta
B
Rollman
Erik
E
D000208:Acute Disease; D000818:Animals; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002908:Chronic Disease; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D015497:HIV-1; D006801:Humans; D008252:Macaca fascicularis; D008562:Membrane Glycoproteins / Q000097:blood*; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood*; D015302:Simian Immunodeficiency Virus; D019562:Viral Load
D044966:Anti-Retroviral Agents; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin