New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.
Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.
Schenone
Silvia
S
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3-16132 Genoa, Italy. schensil@unige.it
Brullo
Chiara
C
Bruno
Olga
O
Bondavalli
Francesco
F
Ranise
Angelo
A
Filippelli
Walter
W
Rinaldi
Barbara
B
Capuano
Annalisa
A
Falcone
Giuseppe
G
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D013276:Stomach Ulcer / Q000150:complications; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000577:Amides; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole; D007213:Indomethacin