The molecular basis of prostate cancer.
Cancer involves accumulation of genetic alterations. This review highlights the alterations in control pathways for cell division, development, DNA repair, angiogenesis and cell death that are believed to be key players in the development of prostate cancer.
Olsson
A Yvonne
AY
Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, Surrey SM2 5NG.
Cooper
Colin S
CS
D017209:Apoptosis / Q000502:physiology; D004260:DNA Repair / Q000502:physiology; D053823:Hedgehog Proteins; D006657:Histones / Q000378:metabolism; D006801:Humans; D008297:Male; D008938:Mitosis / Q000502:physiology; D015513:Oncogene Proteins / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011944:Receptors, Androgen / Q000502:physiology; D016160:Retinoblastoma Protein / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism; D000071676:Zinc Finger Protein GLI1
D053823:Hedgehog Proteins; D006657:Histones; D015513:Oncogene Proteins; D011944:Receptors, Androgen; D016160:Retinoblastoma Protein; D015534:Trans-Activators; D014157:Transcription Factors; D051153:Wnt Proteins; D000071676:Zinc Finger Protein GLI1; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt