title: Prognostic factors for ovulatory response with clomiphene citrate in polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate prospectively the prognostic factors for ovulatory responses following clomiphene citrate (CC) administration in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Fifty-nine infertile patients with a diagnosis of PCOS were recruited. Ovulation was induced using 100 mg/day CC administered daily from days 5 to 9 of the cycle. Endocrine and metabolic parameters between responder and non-responder groups were analyzed.
  
  
  RESULTS
  For a 75-g fasting glucose load (75-g OGTT), blood glucose levels at 60 and 120 min, the area under the curve (AUC) and blood insulin levels at 120 min in the non-responder group (n=25) were significantly higher than those in the responder group (n=34), although the measurements of fasting blood glucose and insulin were not significantly different between the two groups. In the receiver operating characteristic curves, the most appropriate cutoff point was 120 mg/dl for the blood glucose level at 120 min and 9000 for the blood glucose x insulin level at 120 min. There were no significant differences in the clinical characteristics or in the endocrine and metabolic parameters between conceived (n=9) and non-conceived groups (n=21).
  
  
  CONCLUSIONS
  The levels of blood glucose and blood glucose x insulin at 120 min after 75-g OGTT could be good biochemical markers of CC resistance in PCOS. No predictors of conception following CC therapy were identified by this study.
authors.affiliation: Department of Obstetrics and Gynecology, Niigata University School of Medicine, Niigata, Japan. takumi@hosp.niigata.niigata.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Kurabayashi
authors.forename: Mina
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Fujita
authors.forename: Haruo
authors.initials: H
authors.lastname: Murakawa
authors.forename: Isao
authors.initials: I
authors.lastname: Hasegawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D001786:Blood Glucose; D005300:Fertility Agents, Female; D007328:Insulin; D002996:Clomiphene