Cyclotrimerization strategy toward analogues of amaryllidaceae constituents. synthesis of deoxygenated pancratistatin core.
[chemical reaction: see text]. A derivative of pancratistatin having no oxygenation in the aromatic ring was synthesized by a new strategy based on the cobalt-catalyzed cyclotrimerization of acetylenes as a prelude to diversity-oriented synthesis of further analogues.
Moser
Michael
M
Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, Ontario L2S 3A1, Canada.
Sun
Xuetong
X
Hudlicky
Tomas
T
D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure
D047151:Amaryllidaceae Alkaloids; D007546:Isoquinolines; D003035:Cobalt; C044997:pancratistatin