Short and efficient approach towards macrocyclic lactones based on a Sonogashira reaction.
Polyketide-derived macrolactones like zearalenone (1), zearalane (2) or curvularin (3) display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards this class of natural products by a combination of the Sonogashira and Mitsunobu reactions. The resulting lactone 9 was tested against human cancer cell lines at the NCI.
Krauss
Jürgen
J
Department of Pharmacy, Zentrum für Pharmaforschung, LMU Munich, Germany. hjkra@cup.uni-muenchen.de
Unterreitmeier
Doris
D
Neudert
Christine
C
Bracher
Franz
F
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D007783:Lactones; D047028:Macrocyclic Compounds