Parallel and automated library synthesis of 2-long alkyl chain benzoazoles and azole[4,5-b]pyridines under microwave irradiation.
A versatile route to 40-membered library of 2-long alkyl chain substituted benzoazoles (1 and 2) and azole[4,5-b]pyridines (3 and 4) via microwave-assisted combinatorial synthesis was developed. The reactions were carried out in both monomode and multimode microwave oven. With the latter, all reactions were performed in high-throughput experimental settings consisting of an 8 x 5 combinatorial library designed to synthesize 40 compounds. Each step, from the addition of reagents to the recovery of final products, was automated. The microwave-assisted N-long chain alkylation reactions of 2-alkyl-1H-benzimidazole (1) and 2-alkyl-1H-benzimidazole[4,5-b] pyridines (3) were also studied.
Martínez-Palou
Rafael
R
Programa de Ingeniería Molecular, Instituto Mexicano del Petróleo, Eje Central Lázaro Cárdenas No. 152, Mexico, DF, México. rpalou@imp.mx
Zepeda
L Gerardo
LG
Höpfl
Herbert
H
Montoya
Ascensión
A
Guzmán-Lucero
Diego J
DJ
Guzmán
Javier
J
D000478:Alkylation; D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
D001393:Azoles; D011725:Pyridines