title: Castleman's disease as an uncommon cause of a neck mass.
abstract: The detection of Castleman's disease in the neck is uncommon. However, it must be included in the differential diagnosis of a neck mass, together with other lymphoproliferative disorders or thyroid diseases. In 1999, three patients underwent resection of a neck mass of uncertain cytological diagnosis. Frozen-section examinations and immunohistochemical studies using primary antibodies directed against B- and T-cell markers were performed. Very similar features were observed in all cases and the diagnosis of Castleman's disease was based on Frizzera's histological morphological criteria; all cases were of the hyaline vascular type. After surgical resection, the patients remained symptom-free after 51, 50 and 46 months, respectively, without clinical or radiographic signs of local or diffuse recurrence. Surgical removal of a mass of unknown origin located in the central part of the neck is mandatory because it allows a correct diagnosis to be made and is curative when the disease is limited to one site.
authors.affiliation: Department of Medical and Surgical Science, General Surgery III, University of Padua, Padua, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Beraldo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Altavilla
authors.forename: Paolo
authors.initials: P
authors.lastname: Bernante
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Pelizzo
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD; D005871:Castleman Disease / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D005629:Frozen Sections; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016896:Treatment Outcome
chemical_list: D015703:Antigens, CD