title: Acquired coagulation inhibitor-associated bleeding disorders: an update.
abstract: Acquired blood coagulation inhibitors are circulating immunoglobulins that neutralize the activity of a specific coagulation protein or accelerate its clearance from the plasma, thus causing a bleeding tendency. In this review, we focus on the nonhemophilic inhibitors of coagulation, i.e. the autoantibodies occurring in individuals without a pre-existent coagulation defect, reporting the most recent advances in the pathophysiology, diagnosis and treatment of these rare acquired bleeding disorders.
authors.affiliation: Servizio di Immunoematologia e Trasfusione--Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@mail.univr.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Dino
authors.initials: D
authors.lastname: Veneri
mesh_terms: D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001778:Blood Coagulation Disorders / Q000097:blood / Q000276:immunology*; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors* / Q000276:immunology; D006467:Hemophilia A / Q000276:immunology; D006801:Humans
chemical_list: D001323:Autoantibodies; D001779:Blood Coagulation Factors