title: [Genetic polymorphisms of apoptosis-associated genes FAS and FASL and risk of colorectal cancer].
abstract: OBJECTIVE
  The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signaling pathway has been shown to participate in tumorigenesis. We previously have shown that the FAS-1377G/A and FASL-844T/C polymorphisms are associated with esophageal cancer. This case-control study was to examine the contribution of the polymorphisms to susceptibility of colorectal cancer.
  
  
  METHODS
  PCR-RFLP method was used to determine the genotypes of FAS-1377G/A and FASL-844T/C in 382 patients with colorectal cancer and 648 controls. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression model.
  
  
  RESULTS
  The subjects with the AA genotype of FAS-1377G/A and CC genotype of FASL-844T/C had an increased risk for colorectal cancer compared with those with the FAS-1377GG genotype (adjusted OR, 1.65; 95% CI, 1.14-2.38) and FASL-844TT genotype (adjusted OR, 1.76; 95% CI, 1.37-2.28). Furthermore, the effect of FAS and FASL polymorphisms on risk of colorectal cancer displayed a significantly gene-gene interaction (likelihood ratio test, P = 0.002).
  
  
  CONCLUSIONS
  These findings suggest that the FAS-1377G/A and FASL-844T/C polymorphisms may be genetic susceptibility factors for colorectal cancer among Chinese population.
authors.affiliation: Department of Gastroenterological Surgery, Peking University People's Hospial, Beijing 100044, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Yang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Miao
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Tong
authors.initials: T
authors.lastname: Sun
authors.forename: Shi-ning
authors.initials: SN
authors.lastname: Qu
authors.forename: Ping
authors.initials: P
authors.lastname: Xiong
authors.forename: Ying-jiang
authors.initials: YJ
authors.lastname: Ye
authors.forename: Yong-li
authors.initials: YL
authors.lastname: Guo
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D053222:Fas Ligand Protein / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D019014:fas Receptor / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D053222:Fas Ligand Protein; D019014:fas Receptor