title: Vitamin B12 deficiency in infancy as a cause of developmental regression.
abstract: Vitamin B12 deficiency can cause serious developmental regression, hypotonia and cerebral atrophy in infants. We report a 6-month-old infant, with insidious developmental regression and brain atrophy showed by CT scan, secondarily to vitamin B12 deficiency. His mother was a strict vegetarian and the patient was exclusively breastfed. The clinical symptoms and the brain CT were normalized after vitamin B12 administration.
authors.affiliation: Child Neurology Unit, Pediatric Department, University of São Paulo Medical School, São Paulo, Brazil. erasmobc@icr.hcnet.usp.br
authors.forename: Erasmo Barbante
authors.initials: EB
authors.lastname: Casella
authors.forename: Marcelo
authors.initials: M
authors.lastname: Valente
authors.forename: Jessie Medeiros
authors.initials: JM
authors.lastname: de Navarro
authors.forename: Fernando
authors.initials: F
authors.lastname: Kok
mesh_terms: D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001942:Breast Feeding; D002658:Developmental Disabilities / Q000209:etiology*; D014676:Diet, Vegetarian / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D009123:Muscle Hypotonia / Q000209:etiology; D011859:Radiography; D014805:Vitamin B 12 / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000188:drug therapy
chemical_list: D014805:Vitamin B 12