title: Incidence and prevalence of diabetes mellitus in patients with cystic fibrosis undergoing lung transplantation before and after lung transplantation.
abstract: Cystic fibrosis (CF) related diabetes mellitus (DM) occurs in 15% of adult pancreatic insufficient CF patients. Lung transplantation is a treatment option for end-stage CF. We hypothesized that the prevalence of DM increases after lung transplantation. The study population included adult patients undergoing lung transplantation from March 1988 to March 2002 for end-stage CF at the University of Toronto. Demographic data, exocrine pancreatic function, presence of DM before and after transplant, as well as timing of its development after transplant were collected. Eighty-six patients met the study criteria; 77 of 86 (89.5%) of patients were pancreatic insufficient and were further analyzed. Median follow-up post-transplant was 3.3 yr (interquartile range: 1.2-7.2). Their mean age was 29.7 +/- 8.1 yr and 46 of 77 (59.7%) were male. The prevalence of DM increased from 22 of 77 (28.6%) before transplant to 38 of 77 (49.4%) after transplant (p = 0.008). The median time of DM development after transplant was 80 d (range: 13-4352). Sixteen of 55 (29.1%) of pancreatic insufficient patients who were non-diabetic prior to transplant, developed DM after transplant. DM is common in CF patients undergoing lung transplantation and the prevalence increases after transplant.
authors.affiliation: Division of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Pennsylvania Lung Transplant Program, University of Pennsylvania, Philadelphia, PA 19104, USA. Denis.Hadjiliadis@uphs.upenn.edu
authors.forename: Denis
authors.initials: D
authors.lastname: Hadjiliadis
authors.forename: Janet
authors.initials: J
authors.lastname: Madill
authors.forename: Cecilia
authors.initials: C
authors.lastname: Chaparro
authors.forename: Anna
authors.initials: A
authors.lastname: Tsang
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Waddell
authors.forename: Lianne G
authors.initials: LG
authors.lastname: Singer
authors.forename: Michael A
authors.initials: MA
authors.lastname: Hutcheon
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
authors.forename: D
authors.initials: D
authors.lastname: Elizabeth Tullis
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications / Q000453:epidemiology* / Q000601:surgery*; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation; D008297:Male; D011184:Postoperative Period; D015995:Prevalence; D012189:Retrospective Studies; D013997:Time Factors