title: The organization, structure, and inheritance of the ER in higher and lower eukaryotes.
abstract: The endoplasmic reticulum (ER) is a fundamental organelle required for protein assembly, lipid biosynthesis, and vesicular traffic, as well as calcium storage and the controlled release of calcium from the ER lumen into the cytosol. Membranes functionally linked to the ER by vesicle-mediated transport, such as the Golgi complex, endosomes, vacuoles-lysosomes, secretory vesicles, and the plasma membrane, originate largely from proteins and lipids synthesized in the ER. In this review we will discuss the structural organization of the ER and its inheritance.
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06519, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Estrada de Martin
authors.forename: Peter
authors.initials: P
authors.lastname: Novick
authors.forename: Susan
authors.initials: S
authors.lastname: Ferro-Novick
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology*; D006056:Golgi Apparatus; D006801:Humans; D050356:Lipid Metabolism; D015388:Organelles; D011387:Prokaryotic Cells / Q000502:physiology*; D017510:Protein Folding