title: T Cell Immunity and Aging.
abstract: The effect of age on the immune system is generally detrimental and results in "immunosenescence," a poorly-defined state inadequately reflected in clinical data and for which few reliable "biomarkers of aging" are available. The multinational consortium "T-Cell Immunity in Ageing," T-CIA, was set up to examine these issues specifically as applied to T lymphocytes. This Perspective discusses some of the outcomes of a recent conference that considered progress toward resolving these questions in humans.
authors.affiliation: Center for Medical Research, University of Tuebingen, D-72072 Tuebingen, Germany. sven-dominik.koch@student.uni-tuebingen.de
authors.forename: Sven Dominik
authors.initials: SD
authors.lastname: Koch
authors.forename: Juergen
authors.initials: J
authors.lastname: Kempf
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec
mesh_terms: D000375:Aging / Q000235:genetics / Q000276:immunology*; D000941:Antigens; D004249:DNA Damage; D004260:DNA Repair; D023281:Genomics; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D040901:Proteomics; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D000941:Antigens; D006360:Heat-Shock Proteins