title: Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: results of a comparative study.
abstract: OBJECTIVE
  To compare the results of pancreaticogastrostomy versus pancreaticojejunostomy following pancreaticoduodenectomy in a prospective and randomized setting.
  
  
  BACKGROUND
  While several techniques have been proposed for reconstructing pancreatico-digestive continuity, only a limited number of randomized studies have been carried out.
  
  
  METHODS
  A total of 151 patients undergoing pancreaticoduodenectomy with soft residual tissue were randomized to receive either pancreaticogastrostomy (group PG) or end-to-side pancreaticojejunostomy (group PJ).
  
  
  RESULTS
  The 2 treatment groups showed no differences in vital statistics or underlying disease, mean duration of surgery, and need for intraoperative blood transfusion. Overall, the incidence of surgical complications was 34% (29% in PG, 39% in PJ, P = not significant). Patients receiving PG showed a significantly lower rate of multiple surgical complications (P = 0.002). Pancreatic fistula was the most frequent complication, occurring in 14.5% of patients (13% in PG and 16% in PJ, P = not significant). Five patients in each treatment arm required a second surgical intervention; the postoperative mortality rate was 0.6%. PG was favored over PJ due to significant differences in postoperative collections (P = 0.01), delayed gastric emptying (P = 0.03), and biliary fistula (P = 0.01). The mean postoperative hospitalization period stay was comparable in both groups.
  
  
  CONCLUSIONS
  When compared with PJ, PG did not show any significant differences in the overall postoperative complication rate or incidence of pancreatic fistula. However, biliary fistula, postoperative collections and delayed gastric emptying are significantly reduced in patients treated by PG. In addition, pancreaticogastrostomy is associated with a significantly lower frequency of multiple surgical complications.
authors.affiliation: Surgical and Gastroenterological Department, Endocrine and Pancreatic Unit, Hospital G.B. Rossi, University of Verona, 37134 Verona, Italy. claudio.bassi@univr.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Bassi
authors.forename: Massimo
authors.initials: M
authors.lastname: Falconi
authors.forename: Enrico
authors.initials: E
authors.lastname: Molinari
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Butturini
authors.forename: Nora
authors.initials: N
authors.lastname: Sartori
authors.forename: William
authors.initials: W
authors.lastname: Mantovani
authors.forename: Paolo
authors.initials: P
authors.lastname: Pederzoli
mesh_terms: D000704:Analysis of Variance; D016009:Chi-Square Distribution; D005260:Female; D005774:Gastrostomy; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D010193:Pancreaticojejunostomy; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D016896:Treatment Outcome