[Surface active agents in drug forms and biological systems].
The application areas of surface active agents in the pharmaceutical technology are surveyed. Three topics are summarized: (i) application of surfactant as traditional additives, (ii) the role of surfactant in modern drug delivery systems, and (iii) biopharmaceutical use of surfactants in different dosage forms. The team dealing with colloid carriers at the Pharmaceutical-Technological Department in Szeged has worked out several relationships in mathematical form. These relationships establish the formulation and give an exact character to it. Exponential functions were found between contact angle of wetting and the consistency parameters of water free coherent ointment-systems. There is an exponential relationship between contact angle and structure solidification of ointments measured during storage, between contact angle and structure-forming constant of coherent emulsions, and between contact angle and activation energy of thermostability. There is a linear relation between the contact angle of wetting and water uptake ability of absorbing ointments. On the investigation of emulsions a relationship was evaluated between the surfactant amount accumulated of the interface of oil and water phase and the viscosity and stability of emulsions. The amount of surfactant accumulated on the interface can determine the formation of multiple emulsions. On the area of solubilization there is a reciprocal relationship between the surface tension of surfactant solution and the solubilized amount of drugs. On the area of drug liberation a relationship characterized with a maximum curve can be described between the concentration of surfactant and the released drug. These functions can help the formulation of compositions having a suitable bioavailability.
Eros
István
I
Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6.-6720.
D004304:Dosage Forms; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000627:therapeutic use
D004304:Dosage Forms; D004337:Drug Carriers; D013501:Surface-Active Agents