Renal tubular dysgenesis associated with in utero exposure to Nimuselide.
Maternal ingestion of the selective cyclo-oxygenase-2 (COX-2) inhibitor Nimuselide has been reported to be associated with the development of oligohydramnios and neonatal renal failure in some cases. We report a case of neonatal renal failure associated with maternal ingestion of Nimuselide in the third trimester of pregnancy. The neonate presented with metabolic acidosis and non-oliguric renal failure on the second day of life. The renal histopathology showed evidence of renal tubular dysgenesis. The child continues to have elevated serum creatinine and hypertension at 10 months of age.
Ali
Uma Sankari
US
Division of Nephrology, B.J. Wadia Hospital for Children and Research Centre, Mumbai, India. dr_usali@yahoo.com
Khubchandani
Sheila
S
Andankar
Parmanand
P
Parekhji
Shashank
S
Dubhalish
Vishal
V
Padhye
Bhavna
B
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007684:Kidney Tubules / Q000002:abnormalities*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D051437:Renal Insufficiency / Q000139:chemically induced*; D013449:Sulfonamides / Q000009:adverse effects*
D016861:Cyclooxygenase Inhibitors; D013449:Sulfonamides; C012655:nimesulide