title: [A role of the basal ganglia in the occurrence of visual hallucinations (a hypothetical mechanism)].
abstract: A hypothetical mechanism of the basal ganglia involvement in visual hallucinations is proposed. According to this mechanism, hallucination is the result of modulation of the efficacy of corticostriatal synaptic inputs and changes in spiny cell activity due to the rise of striatal dopamine concentration (or due to other reasons). These changes cause an inhibition of neurons in the substantia nigra pars reticulata and subsequent disinhibition of neurons in the superior colliculus and pedunculopontine nucleus (including its cholinergic cells). In the absence of afferentation from the retina this disinhibition leads to activation of neurons in the lateral geniculate nucleus, pulvinar and other thalamic nuclei projecting to the primary and highest visual cortical areas, prefrontal cortex, and also back to the striatum. Hallucinations as conscious visual patterns are the result of selection of signals circulating in several interconnected loops each of which includes one of above mentioned neocortical areas, one of thalamic nuclei, limbic and one of visual areas of the basal ganglia, superior colliculus and/or pedunculopontine nucleus. According to our model, cannabinoids, opioids and ketamine may lead to hallucinations due to their promotional role in the LTD of cortical inputs to GABAergic spiny cells of striatal striosomes projecting to dopaminergic neurons, disinhibition of the lasts, and increase in striatal dopamine concentration.
authors.forename: I G
authors.initials: IG
authors.lastname: Sil'kis
mesh_terms: D001479:Basal Ganglia / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D003342:Corpus Striatum / Q000503:physiopathology; D006212:Hallucinations / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D045042:Pedunculopontine Tegmental Nucleus / Q000503:physiopathology; D013378:Substantia Nigra / Q000503:physiopathology; D013477:Superior Colliculi / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology; D014795:Visual Pathways / Q000503:physiopathology