Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis.
BACKGROUND
Caveolin-1 is implicated in the oncogenic transformation of cells as a tumor suppressor. In several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL).


METHODS
Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression.


RESULTS
Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression. However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size.


CONCLUSIONS
These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is a marker for predicting prognosis in PCL.
Moon
Kyung Chul
KC
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Lee
Geon Kook
GK
Yoo
Seong-Ho
SH
Jeon
Yoon Kyung
YK
Chung
Jin-Haeng
JH
Han
Jungho
J
Chung
Doo Hyun
DH
D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D051242:Caveolin 1 / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D012189:Retrospective Studies
D051242:Caveolin 1