title: Insulin-like growth factor I, growth hormone and insulin in white adipose tissue.
abstract: Maturation of adipose tissue results from both the expansion of mature adipocytes and the formation of new adipocytes from adipocyte precursor cells. A variety of hormones related to adipogenesis have been identified recently. Both growth hormone (GH) and insulin-like growth factor I (IGF-I) are of major significance in adipocyte differentiation. IGF-I has been suggested to be a major regulator of cell proliferation, differentiation and metabolism, thus regulating, among other biological processes, adipose tissue growth and differentiation of pre-adipocytes into adipocytes. GH exerts its effects by increasing the pool of adipocyte precursor cells capable of differentiating into mature adipocytes. In addition, GH seems to have the potential to reduce the volume of mature adipocytes, thus inhibiting the expansion of adipose tissue and reducing body fat. This chapter gives an overview of studies that have investigated the roles of insulin, GH and IGF-I in adipogenesis.
authors.affiliation: Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21-25, Germany.
authors.forename: Susann
authors.initials: S
authors.lastname: Blüher
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
mesh_terms: D017667:Adipocytes / Q000502:physiology; D050156:Adipogenesis / Q000502:physiology; D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008297:Male; D051379:Mice; D051381:Rats
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone