Visceral, inflammatory and neuropathic pain in glycine receptor alpha 3-deficient mice.
The alpha3-subunit of strychnine-sensitive glycine receptors is an important modulator of the pain-sensitizing effects of spinal prostaglandin prostaglandin E(2). Mice deficient for alpha3-subunit of strychnine-sensitive glycine receptors lack the prostaglandin E(2)-induced inhibition of glycinergic neurotransmission and recover faster from inflammation-induced hyperalgesia. It, however, remains unclear whether alpha3-subunit of strychnine-sensitive glycine receptors plays a role in other pain models involving prostaglandin synthesis, such as chemically induced pain or neuropathic pain. In this paper, we show a reduction of acetic acid-induced writhing responses in the absence of alpha3-subunit of strychnine-sensitive glycine receptors, but no changes in formalin-induced pain. Furthermore, alpha3-subunit of strychnine-sensitive glycine receptors-deficient mice develop normal thermal hyperalgesia and tactile allodynia. Thus, alpha3-subunit of strychnine-sensitive glycine receptors is involved in the modulation of moderate inflammatory acetic acid-induced pain responses, but neither in formalin-induced pain nor in neuropathic pain.
Rácz
Ildikó
I
Laboratory of Molecular Neurobiology, Department of Psychiatry, University of Bonn, Bonn, Germany.
Schütz
Burkhard
B
Abo-Salem
Osama M
OM
Zimmer
Andreas
A
D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D005557:Formaldehyde / Q000009:adverse effects; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology*; D007509:Irritants / Q000009:adverse effects; D051379:Mice; D008817:Mice, Mutant Strains; D009437:Neuralgia / Q000209:etiology / Q000503:physiopathology; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D010147:Pain Measurement; D018009:Receptors, Glycine / Q000172:deficiency / Q000378:metabolism*; D012584:Sciatic Nerve / Q000293:injuries; D014781:Viscera / Q000187:drug effects
D007509:Irritants; D018009:Receptors, Glycine; C113965:glycine receptor alpha3 subunit; D005557:Formaldehyde; D019342:Acetic Acid