Regional cerebral blood flow change in a case of Alzheimer's disease with musical hallucinations.
We examined alteration of regional cerebral blood flow (rCBF) in a case of Alzheimer's disease (AD) patient with musical hallucination. To detect regions related to musical hallucination, single-photon emission computed tomography (SPECT) imaging of the patient and nine sex, age, and cognitive function-matched AD patients without delusions and hallucinations were compared using statistical parametric mapping 99 (SPM99). In comparison with controls, the patient had increased rCBF in left temporal regions and left angular gyrus. This profile could be relevant to the neuroanatomical basis of musical hallucinations.
Mori
Takaaki
T
Department of Neuropsychiatry, Ehime University School of Medicine, Toon city, Ehime 791-0295, Japan.
Ikeda
Manabu
M
Fukuhara
Ryuji
R
Sugawara
Yoshifumi
Y
Nakata
Shigeru
S
Matsumoto
Naomi
N
Nestor
Peter J
PJ
Tanabe
Hirotaka
H
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D006212:Hallucinations / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009146:Music; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon