title: Chronic otitis media with effusion and Helicobacter pylori.
abstract: OBJECTIVE
  The aim of this study is to investigate the presence of Helicobacter pylori (HP) in the middle ear effusion by Campylobacter-like organism (CLO) test and whether it has a role in the ethiopathogenesis of chronic otitis media with effusion (OME).
  
  
  METHODS
  A prospective randomized and controlled study.
  
  
  METHODS
  This study was performed with 45 patients with the diagnosis of chronic OME and adenoid hypertrophy, between the ages 3 and 13 (median 6). Thirty patients constituted the study group (18 male (60%) and 12 (40%) female). Adenoidectomy with myringotomy with ventilation tube insertion were performed to this group. Middle ear effusion and adenoid tissue pieces were collected and H. pylori presence was investigated by "CLO" testing. Fifteen patients of the matching age group (9 male (66.7%) and 6 (33.3%) female) constituted the control group to whom adenoidectomy with myringotomy were performed but no middle ear effusion could be determined (empty myringotomy patients). The wash out liquid of middle ear and pieces of adenoid tissue samples were also collected from the control group. By using CLO testing, the presence of H. pylori was investigated in the adenoid tissues and middle ear of the empty myringotomy patients.
  
  
  RESULTS
  In 20 (66.6%) patients of the study group, CLO testing was positive in the middle ear effusions. None of the patients demonstrated positive CLO test in the wash out liquid of middle ear. There was significant difference of positive CLO testing in the middle ear effusions of two groups (p<0.001).
  
  
  CONCLUSIONS
  These findings showed us that presence of HP in the middle ear effusion using CLO testing and this may be responsible for the ethiopathogenesis of chronic OME.
authors.affiliation: Akdeniz University, Medical Faculty, ENT & HNS, Arapsuyu, Akdeniz, Antalya 07070, Turkey. abulent@akdeniz.edu.tr
authors.forename: Bulent V
authors.initials: BV
authors.lastname: Agirdir
authors.forename: Selami
authors.initials: S
authors.lastname: Bozova
authors.forename: Alper T
authors.initials: AT
authors.lastname: Derin
authors.forename: Murat
authors.initials: M
authors.lastname: Turhan
mesh_terms: D000234:Adenoids / Q000382:microbiology / Q000473:pathology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D006984:Hypertrophy; D008297:Male; D010034:Otitis Media with Effusion / Q000382:microbiology*; D011446:Prospective Studies; D014510:Urease
chemical_list: D014510:Urease