title: [A study on the promoting effects of recombinant human epidermal growth factor on skin wound healing in rats].
abstract: OBJECTIVE
  To observe the effects of recombinant human epidermal growth factor (rhEGF) on skin wound healing.
  
  
  METHODS
  The dorsal trauma model of rats was used. A total of 68 dorsal wounds in 34 rats were created and divided into the rhEGF group and the isotonic saline group according to self-control. The process of wound healing was observed and a mean healing time was calculated. Furthermore, the dynamic analysis was performed at different times on wound OHP contents, ratio of collagen I/III and cell DNA cycle.
  
  
  RESULTS
  The wound healing was accelerated obviously in all wounds treated with rhEGF. The mean time of wound healing of the two groups was (17.2 +/- 1.3) days and (20.5 +/- 1.6) days respectively (P < 0.01). In the rhEGF group, the new granulation tissue was more and the re-epithelialization was faster than that of the saline group. External rhEGF increased OHP content, reduced collagen I/II ratio and accelerated cell DNA replication.
  
  
  CONCLUSIONS
  External rhEGF can shorten wound healing time, increase granulation tissue and OHP contents, reduce collagen I/III ratio and accelerate cell DNA replication, thus obviously promoting skin wound repair.
authors.affiliation: Department of Burn and Plastic Surgery, Xiang Ya Hospital, Central South University, Hunan Changsha 410008, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.forename: Xiao-Yuan
authors.initials: XY
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: Wei
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology*; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D011994:Recombinant Proteins; D004815:Epidermal Growth Factor