title: Blockade of angiotensin II and aging: is the spontaneously hypertensive rat a suitable model?
authors.forename: Jeremy B
authors.initials: JB
authors.lastname: Tuttle
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D019808:Losartan / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D004232:Diuretics; D019808:Losartan