title: Interstitial nephritis and high titers of PR3-ANCA: an unusual manifestation of ANCA-associated disease.
abstract: We present the case of a 75-year-old female with weight loss, anemia, systemic signs of inflammation, mild renal insufficiency, microscopic hematuria, mixed glomerular and tubular proteinuria, and high titers of PR3-ANCA. Renal biopsy demonstrated interstitial nephritis with some sclerosed but otherwise normal glomeruli. Extensive work-up showed no signs of granulomatous inflammation or other vasculitic organ involvement. We presumed this to be a rare renal manifestation of ANCA-associated disease with the presence of sclerosed glomeruli suggesting a previous history of glomerular involvement. In view of the absence of active vasculitic or granulomatous disease, treatment was limited to low-dose corticosteroids with good response.
authors.affiliation: Nephrology Department, Medical Clinic I, University Hospital München-Grosshadern, LMU München, Germany. Ulf.Schoenermarck@med.uni-muenchen.de
authors.forename: U
authors.initials: U
authors.lastname: Schönermarck
authors.forename: C A
authors.initials: CA
authors.lastname: Schirren
authors.forename: N
authors.initials: N
authors.lastname: Mistry-Burchardi
authors.forename: M
authors.initials: M
authors.lastname: Weiss
authors.forename: P
authors.initials: P
authors.lastname: Eichhorn
authors.forename: W
authors.initials: W
authors.lastname: Samtleben
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D053146:Myeloblastin; D009395:Nephritis, Interstitial / Q000097:blood*; D012697:Serine Endopeptidases / Q000097:blood*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D012697:Serine Endopeptidases; D053146:Myeloblastin