title: Comparative fixation of tibial plateau fractures using alpha-BSM, a calcium phosphate cement, versus cancellous bone graft.
abstract: OBJECTIVE
  To compare the compressive strength of a bone substitute material (alpha-BSM) to cancellous bone when used to fill a defect void in a cadaver model of a Schatzker II split depression fracture of the lateral tibial plateau.
  
  
  METHODS
  Randomized, paired design.
  
  
  METHODS
  Biomedical engineering laboratory.
  
  
  METHODS
  Twenty-six human tibias were harvested from 13 cadavers. Three pairs of tibia fractured during preparation and were excluded. The remaining 10 matched pairs were randomized to fixation by using the bone substitute material or cancellous bone.
  
  
  METHODS
  A split depression fracture of the lateral tibial plateau was created in each tibia by using reproducible methods. This fracture was stabilized with a stainless steel L-plate and screws and either alpha-BSM or cancellous bone to fill the defect void.
  
  
  METHODS
  Stiffness of the elevated fragment in compression, total depression of the joint at 1000 N.
  
  
  RESULTS
  The alpha-BSM bone substitute displayed significantly greater stiffness than cancellous bone constructs in Schatzker II split depression fractures of the lateral tibial plateau (P < 0.0001). Plateau defects displaced significantly less at 1000 N when using alpha-BSM in comparison to cancellous bone (P < 0.0001).
  
  
  CONCLUSIONS
  In this cadaveric study, alpha-BSM is an effective bone substitute compared with cancellous bone graft for stabilizing split depression fractures of the lateral tibial plateau.
authors.affiliation: Dalhousie University School of Biomedical Engineering, Halifax, Nova Scotia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Trenholm
authors.forename: Scott
authors.initials: S
authors.lastname: Landry
authors.forename: Kyle
authors.initials: K
authors.lastname: McLaughlin
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Deluzio
authors.forename: Jennifer
authors.initials: J
authors.lastname: Leighton
authors.forename: Kelly
authors.initials: K
authors.lastname: Trask
authors.forename: Ross K
authors.initials: RK
authors.lastname: Leighton
mesh_terms: D001843:Bone Cements / Q000627:therapeutic use*; D001860:Bone Plates; D001863:Bone Screws; D016025:Bone Transplantation / Q000379:methods*; D002102:Cadaver; D002130:Calcium Phosphates / Q000627:therapeutic use*; D019245:Compressive Strength; D005592:Fracture Fixation / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D013978:Tibial Fractures / Q000628:therapy*; D016896:Treatment Outcome; D016474:Weight-Bearing
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate