Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor.
Prenylflavonoids and lavandulylflavonoids were isolated from the roots of Sophora flavescens Aiton (Fabaceae). The ability of 8-prenylkaempferol (1), kushenol X (2), norkurarinone (3), leachianone A (4), kushenol C (5), maackiain (6) and a root-extract of S. flavescens to displace 17beta-estradiol (E2) from rat uterine estrogen receptor (ER) was determined. Relative binding affinities (RBA) of prenylated flavonoids were weak with RBA values between 0.004 and 0.072. A lavandulyl or prenyl group at the position 8 enhanced binding to rat uterine ER.
Hillerns
Pablo Ibieta
PI
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Germany.
Wink
Michael
M
D000818:Animals; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000378:metabolism*; D029909:Sophora / Q000737:chemistry*; D014599:Uterus / Q000378:metabolism
D005419:Flavonoids; D010936:Plant Extracts; D011960:Receptors, Estrogen