Formation of the thalamocortical projection regulated differentially by BDNF- and NT-3-mediated signaling.
During development thalamocortical (TC) axons establish lamina-specific connections with cortical cells, and in later developmental stages TC projections are modified by activity-dependent processes. Recent studies have demonstrated that brain-derived neurotrophic factor and neurotrophin-3 are expressed in the cortex with distinct developmental time courses, and are involved not only in the formation of the TC projection but also in the subsequent refinement processes. Evidence further suggests that these actions of neurotrophins are achieved in cooperation with membrane-associated molecules expressed in cortical cells.
Yamamoto
Nobuhiko
N
Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, Japan. nobuhiko@fbs.osaka-u.ac.jp
Hanamura
Kenji
K
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D020933:Neurotrophin 3 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013788:Thalamus / Q000166:cytology / Q000196:embryology* / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D020933:Neurotrophin 3