Pattern visual evoked potentials in eyes with disc swelling due to cat scratch disease-associated neuroretinitis.
OBJECTIVE
To evaluate optic nerve function by pattern visual evoked potentials (VEPs) in eyes with optic disc swelling due to neuroretinitis associated with cat scratch disease (CSD).


METHODS
Four eyes of four patients with marked optic disc swelling resembling optic neuritis but diagnosed serologically as CSD received systemic steroid treatment. VEPs elicited by black and white checkerboard stimuli created on a TV monitor were recorded before the treatment.


RESULTS
The visual acuity (VA) in the affected eyes was decreased to 20/50 in two eyes and finger counting in two eyes at their initial visits. Ophthalmoscopic examination revealed neuroretinitis characterized by severe optic disc swelling, chorioretinal exudates, and macular edema in all eyes. Anti-Bartonella henselae serum antibody was markedly elevated in all patients confirming the diagnosis of CSD. The P100 of the transient VEPs was only mildly reduced without a delay in the implicit times in three eyes and only slightly delayed in the other eye. The steady-state VEPs were mildly reduced in two eyes and phase-reversed in other two eyes. The VA fully recovered after systemic steroid treatment in all patients.


CONCLUSIONS
Although all examined patients showed marked swelling of the optic disc and visual decrease, the pattern VEPs were not affected as severely as in idiopathic optic neuritis. However, the degree of change of the pattern VEPs varied among patients.
Chai
Yuzhu
Y
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.
Yamamoto
Shuichi
S
Hirayama
Atsuko
A
Yotsukura
Jiro
J
Yamazaki
Hiroko
H
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D018416:Bartonella henselae / Q000276:immunology; D002372:Cat-Scratch Disease / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008269:Macular Edema / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014792:Visual Acuity
D000907:Antibodies, Bacterial