Mouse phenogenomics: the fast track to "systems metabolism".
With the completion of the many genomes, genetics is positioned to meet physiology. In this review, we summarize the coming of "systems metabolism" in mammals through the use of the mouse, as a model system to study metabolism. Building on mouse genetics with increasingly sophisticated clinical and molecular phenotyping strategies has enabled scientists to now tackle complex biomedical questions, such as those related to the pathogenesis of the common metabolic disorders. The ultimate goal of such strategies will be to mimic human metabolism with the click of a mouse.
Argmann
Carmen A
CA
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut Nationale de la Santé et de la Recherche Médicale/Université Louis Pasteur, 67404 Illkirch, France.
Chambon
Pierre
P
Auwerx
Johan
J
D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure; D003198:Computer Simulation; D003433:Crosses, Genetic; D005818:Genetic Engineering; D016678:Genome; D023281:Genomics; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008957:Models, Genetic; D010597:Pharmacogenetics / Q000379:methods*; D010641:Phenotype; D049490:Systems Biology