Homologous recombination is promoted by translesion polymerase poleta.
Two new studies provide in vivo ( [this issue of Molecular Cell]) and in vitro ( [this issue of Molecular Cell]) evidence that poleta functions to extend 3' strands exchanged during homologous recombination and raise the issue of how TLS polymerases are selected onto different substrates.
Rattray
Alison J
AJ
Gene Regulation and Chromosome Biology Laboratory, NCI-Frederick, P.O. Box B, Maryland 21702, USA.
Strathern
Jeffrey N
JN
D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008957:Models, Genetic; D051135:Rad51 Recombinase / Q000378:metabolism; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D000099270:Y-Family DNA Polymerases
D004247:DNA; D004259:DNA-Directed DNA Polymerase; D051135:Rad51 Recombinase; C112338:Rad30 protein; D000099270:Y-Family DNA Polymerases