Paternal age and epilepsy in the offspring.
Advanced paternal age is associated with a higher rate of de novo mutation in sperm cells and mental disorders in the offspring. In a population based cohort study of 96,654 children, we found that fathers aged 35 years or more were slightly more likely to have a child diagnosed with epilepsy compared to fathers aged 25-29 years. Our data suggest a modest paternal effect on the aetiology of epilepsy.
Vestergaard
Mogens
M
The Danish Epidemiology Science Centre, Institute of Public Health, Department of Epidemiology, University of Aarhus, DK-8000, Aarhus C, Denmark. mv@soci.au.dk
Mork
Alissa
A
Madsen
Kreesten M
KM
Olsen
Jørn
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D009154:Mutation; D010331:Paternal Age; D013094:Spermatozoa