[Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis].
The urine concentration of IL-6, IL-8 and nitric oxide (NO) were determined in the patients with pyelonephritis and hydronephrosis. Correlations between urine levels of IL-6 and IL-8 and amount of nitric oxide in the hydronephrosis patients were not found. However, in the patients with both acute and chronic pyelonephritis the coefficient of correlation was high, r((IL-6/NO)) = 0,94 and r((IL-8/NO)) = 0,86 for acute and r((IL-6/NO)) = 0,72 and r((IL-8/NO)) = 0,40 for chronic forms, respectively. These data suggest that secretion of NO during hydronephrosis has a compensatory character and acted on renal microvascular tone, whereas during pyelonephritis NO produced inflammatory mediators by recruiting leukocytes and has pathogenic character.
Dzhodzhua
G N
GN
Kochiashvili
D K
DK
D000328:Adult; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000276:immunology / Q000652:urine*; D015850:Interleukin-6 / Q000652:urine*; D016209:Interleukin-8 / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000652:urine*; D011704:Pyelonephritis / Q000276:immunology* / Q000652:urine*
D015850:Interleukin-6; D016209:Interleukin-8; D009569:Nitric Oxide