title: Clinical implications and mechanisms of plaque rupture in the acute coronary syndromes.
abstract: Coronary atherosclerosis complicated by plaque rupture or disruption and thrombosis is primarily responsible for the development of acute coronary syndromes. Plaques with a large extracellular lipid-rich core, a thin fibrous cap due to reduced collagen content and smooth muscle density, and increased numbers of activated macrophages and mast cells appear to be vulnerable to rupture. Plaque disruption tends to occur at points at which the plaque surface is weakest and most vulnerable, which coincide with points at which stresses resulting from biomechanical and hemodynamic forces acting on plaques are concentrated. Reduced matrix synthesis as well as increased matrix degradation predisposes vulnerable plaques to rupture in response to extrinsic mechanical or hemodynamic stresses. Modification of endothelial dysfunction and reduction of vulnerability to plaque rupture and thrombosis may lead to plaque stabilization. These concepts have significant clinical implications that are just beginning to be explored and incorporated into clinical practice. This article reviews the mechanism of coronary atherosclerosis development and the pathophysiology of acute coronary syndromes to provide a framework for understanding how plaque passivation might be accomplished in clinical medicine.
authors.affiliation: Section of Cardiology, Rush Medical College, Rush University Medical Center, Chicago, IL, USA. lklein@rush.edu
authors.forename: Lloyd W
authors.initials: LW
authors.lastname: Klein
mesh_terms: D000208:Acute Disease; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology; D003327:Coronary Disease / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000473:pathology; D018384:Oxidative Stress; D013314:Stress, Mechanical; D013927:Thrombosis / Q000209:etiology / Q000473:pathology*