[Effect of aggregation extent of microperoxidase-8 on its interaction with La3+].
Oxygen of two propionic acid groups of the heme group in an MP-8 molecule, leading to an increase in the non-planarity of the porphyrin ring of the heme group. The increasing extent in the non-planarity of the porphyrin ring of the heme group due to the interaction of La3+ and MP-8 molecule would be significantly decreased because NaCl could increase the aggregation extent of MP-8 molecules. Although methanol can reduce the aggregation extent of MP-8 molecules, it has little influence on the increasing extent in the non-planarity of the porphyrin ring of the heme group due to the interaction of La3+ and MP-8 molecule.
Chen
Ting-ting
TT
College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China.
Huang
Xiao-hua
XH
Du
Jiang-yan
JY
Feng
Yu-ying
YY
Liu
Chang-peng
CP
Xing
Wei
W
Lu
Tian-hong
TH
D006418:Heme / Q000737:chemistry; D007811:Lanthanum / Q000737:chemistry* / Q000378:metabolism; D000432:Methanol / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D010544:Peroxidases / Q000737:chemistry* / Q000378:metabolism; D011166:Porphyrins / Q000737:chemistry; D011422:Propionates / Q000737:chemistry; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation / Q000187:drug effects; D012965:Sodium Chloride / Q000737:chemistry / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D011166:Porphyrins; D011422:Propionates; C028521:lanthanum chloride; D006418:Heme; D012965:Sodium Chloride; D007811:Lanthanum; D010544:Peroxidases; C021799:microperoxidase; C029658:propionic acid; D010100:Oxygen; D000432:Methanol