[Immunogenetic factors associated with type 1 diabetes mellitus].
Type 1 diabetes mellitus has been considered an organ-specific autoimmune disease derived from the selective destruction of pancreatic beta cells. It presents a complex pathogenesis, involving the participation of several factors, including the immunogenetic susceptibility with strong association to histocompatibility genes (HLA), environmental events and autoimmune response with the presence of autoantibodies and/or autoreactive lymphocytes, culminating in metabolic abnormalities. In this study, the literature review describes mechanisms through which some factors cause susceptibility to its appearance and, additionally, prediction innovations regarding this disorder, which will certainly contribute to nursing care for patients with type 1 diabetes.
Fernandes
Ana Paula Morais
AP
anapaula@eerp.usp.br
Pace
Ana Emilia
AE
Zanetti
Maria Lúcia
ML
Foss
Milton Cesar
MC
Donadi
Eduardo Antonio
EA
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology*; D006801:Humans