title: Proliferative changes of epidermal cells in lesions of cutaneous leishmaniasis.
abstract: In 35 parasitologically proven zoonotic cutaneous leishmaniasis patients, the histopathological and immunohistochemical picture were studied. The haematoxylin and eosin stain, the monoclonal antibodies for T & B lymphocytes, peroxidase anti-peroxidase for P53 protein, and Feulgen staining for DNA imaging cytometry to DNA contents and S-phase (DNA synthesis of cycling cells were evaluated. The out-come results revealed that P53 and S-phase fraction and DNA content must be in mind when dealing with a human cutaneous leishmaniasis. Consequently, the early detection of any nuclear mutation and cellular proliferation in the skin leishmaniasis lesion(s) must be taken into consideration to avoid the miserable formation of the skin cancer.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Zagazig, Zagazig.
authors.forename: Amal M
authors.initials: AM
authors.lastname: Mangoud
authors.forename: Eman M
authors.initials: EM
authors.lastname: Sanad
authors.forename: Mohammad A H
authors.initials: MA
authors.lastname: Fouad
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002455:Cell Division; D002648:Child; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D018320:Leishmania major; D016773:Leishmaniasis, Cutaneous / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000469:parasitology / Q000473:pathology