title: Neonatal handling reduces angiotensin II receptor density in the medial preoptic area and paraventricular nucleus but not in arcuate nucleus and locus coeruleus of female rats.
abstract: Neonatal handling alters the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-gonads axis (HPG) in adult animals, and angiotensin II (Ang II) modulates the functions in these axes. We tested whether neonatal handling could change the density of Ang II receptors in some central areas in female rats. Results showed decreased density of the Ang II receptors in the medial preoptic area (MPOA) and hypothalamic paraventricular nucleus (PVN) of the neonatal handled group.
authors.affiliation: Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Rua Sarmento Leite 500, Porto Alegre, RS 90050-170, Brazil.
authors.forename: Cármen Marilei
authors.initials: CM
authors.lastname: Gomes
authors.forename: Márcio Vinícius Fagundes
authors.initials: MV
authors.lastname: Donadio
authors.forename: Inélia
authors.initials: I
authors.lastname: Franskoviaki
authors.forename: Janete A
authors.initials: JA
authors.lastname: Anselmo-Franci
authors.forename: Celso Rodrigues
authors.initials: CR
authors.lastname: Franci
authors.forename: Aldo Bolten
authors.initials: AB
authors.lastname: Lucion
authors.forename: Gilberto Luiz
authors.initials: GL
authors.lastname: Sanvitto
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D005260:Female; D006234:Handling, Psychological; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008125:Locus Coeruleus / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011945:Receptors, Angiotensin / Q000502:physiology*
chemical_list: D011945:Receptors, Angiotensin