Ki67 and doublecortin positive cells in the human prefrontal cortices of normal aging and vascular dementia.
Immunohistochemical localizing of the proliferation of Ki67 nuclei and doublecortin positive cells were performed in the prefrontal cortex of normal aged and vascular dementia (multiple infarct dementia) patients. Positive Ki67 nuclei and doublecortin positive cells were observed in both groups, with slightly higher density in the prefrontal cortex of vascular dementia. When the Ki67 sites were superimposed with the neuronal specific enolase localizations, only about 5% of the cells was doubly labeled, indicating few proliferating cells were neurons. This percentage did not vary between specimens of normal aging and those of vascular dementia.
Lu
Gang
G
Department of Anatomy, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Wai
Sen Mun
SM
Poon
W S
WS
Yew
D T
DT
D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D015161:Dementia, Multi-Infarct / Q000378:metabolism*; D000089622:Doublecortin Domain Proteins; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000166:cytology* / Q000378:metabolism
D000089622:Doublecortin Domain Proteins; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides