Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism.
Apigenin 7-O-beta-D-glucopyranuronide (1), luteolin 7-O-beta-D-glucopyranuronide (2), m-hydroxybenzyl beta-D-glucoside (3), and chrysoeriol 7-O-beta-D-glucopyranuronide (4) were isolated for the first time from the leaves of Salix matsudana. Furthermore, the effects of compounds 1, 2 and 3 on arachidonic acid metabolism were studied. These compounds inhibited significantly the production of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE). In addition, the aglycon apigenin inhibited not only 12-HETE but also thromboxane B(2) (TXB(2)). The effect of compound (4) on arachidonic acid metabolism is now under investigation.
Zheng
Yi-Nan
YN
Chinese Material Medicine College of Jilin Agricultural University, Changchun-City, Jilin 130118, China.
Zhang
Jing
J
Han
Li-Kun
LK
Sekiya
Keizo
K
Kimura
Yoshiyuki
Y
Okuda
Hiromichi
H
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000378:metabolism; D000818:Animals; D047310:Apigenin / Q000302:isolation & purification / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism*; D002478:Cells, Cultured; D003864:Depression, Chemical; D047309:Flavones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D047311:Luteolin / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D032108:Salix / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013929:Thromboxane B2 / Q000378:metabolism
D047309:Flavones; D005419:Flavonoids; D005960:Glucosides; D016718:Arachidonic Acid; D013929:Thromboxane B2; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; C057792:apigetrin; D047310:Apigenin; C066408:luteolin-7-glucoside; D047311:Luteolin; C007054:chrysoeriol