title: Protective effects of tea polyphenols and caffeine.
abstract: Compounds derived from botanical sources, such as polyphenols from tea, have been of interest as possible therapeutic agents. Their benefits in terms of cancer chemoprevention have also been investigated primarily through in vitro and animal in vivo studies. Ultraviolet light from solar radiation has been proven to initiate and promote skin cancer, which is the most common malignancy in light-skinned populations. This review discusses the effects of tea polyphenols in preventing cutaneous carcinogenesis. Although many of the mechanisms and pathways discussed may be applicable to other carcinogens, this review focuses mainly on those related to ultraviolet light-induced processes and potential action sites for tea polyphenols. Since caffeine is a component of tea, and has also been suggested as a possible chemoprotective agent, it is included in this review. Based on data from numerous studies published in the scientific literature, tea polyphenols are promising chemopreventive agents against ultraviolet-induced skin cancers. Their antioxidant properties, inhibitory effects on signal transduction pathways, cell proliferation, angiogenesis and capacity for apoptosis induction, as well as possible immune protective effects, are among the mechanisms that contribute to skin cancer prevention.
authors.affiliation: Department of Dermatology, University Hospitals and Case Western Reserve University, Lakeside 3500, Cleveland, OH 44106, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Camouse
authors.forename: Kaija K
authors.initials: KK
authors.lastname: Hanneman
authors.forename: Edward P
authors.initials: EP
authors.lastname: Conrad
authors.forename: Elma D
authors.initials: ED
authors.lastname: Baron
mesh_terms: D000975:Antioxidants; D017209:Apoptosis; D002110:Caffeine / Q000494:pharmacology*; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D018890:Chemoprevention; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009389:Neovascularization, Pathologic; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000517:prevention & control*; D013662:Tea / Q000737:chemistry*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D061965:Matrix Metalloproteinase Inhibitors; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D002110:Caffeine; D020782:Matrix Metalloproteinases