title: Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines.
abstract: A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).
authors.affiliation: Laboratoire de Pharmacognosie et Groupe Chimiothérapie Antiparasitaire (associé au CNRS-BioCIS) Faculté de Pharmacie, Université de Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France.
authors.forename: Xu
authors.initials: X
authors.lastname: Hui
authors.forename: Julie
authors.initials: J
authors.lastname: Desrivot
authors.forename: Christian
authors.initials: C
authors.lastname: Bories
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Loiseau
authors.forename: Xavier
authors.initials: X
authors.lastname: Franck
authors.forename: Reynald
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: Bruno
authors.initials: B
authors.lastname: Figadère
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007893:Leishmania donovani / Q000187:drug effects; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects; D014346:Trypanosoma brucei brucei / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D011810:Quinoxalines