title: Gamma-delta hepatosplenic T-cell lymphoma. Description of a case with immunophenotypic and molecular follow-up successfully treated with chemotherapy alone.
abstract: This study hereby reports the case of a 19-year old boy with a gamma-delta hepatosplenic T-cell lymphoma (HSTCL). Initial therapy consisted of four cycles of the IEV (Ifosphamide, Epirubicin and Etoposide) scheme. Further treatment strategy was then adapted according to minimal residual disease monitoring by immunophenotypic and T-cell receptor gamma chain gene evaluation. The patient remains in complete clinical, immunological and molecular remission and in good clinical conditions 48 months after diagnosis and 40 months after stopping therapy.
authors.affiliation: Division of Haematology, Department of Cellular Biotechnologies and Hematology, University La Spienza, Rome, Italy. moleti@bce.uniroma1.it
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Moleti
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Testi
authors.forename: Fiorina
authors.initials: F
authors.lastname: Giona
authors.forename: Angela
authors.initials: A
authors.lastname: Amendola
authors.forename: Giovanna
authors.initials: G
authors.lastname: Palumbo
authors.forename: Stefania
authors.initials: S
authors.lastname: Uccini
authors.forename: Irene Della
authors.initials: ID
authors.lastname: Starza
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: de Propris
authors.forename: Anna
authors.initials: A
authors.lastname: Guarini
authors.forename: Robin
authors.initials: R
authors.lastname: Foà
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D008297:Male; D018365:Neoplasm, Residual; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis*; D012074:Remission Induction; D012680:Sensitivity and Specificity; D013163:Splenomegaly / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta