Aquaporin-1: a novel promoter of tumor angiogenesis.
Angiogenesis is critical to solid tumor growth; therefore, understanding how blood vessels form within a developing tumor has become a principal, yet challenging, objective. The recent discovery that deletion of the water channel protein, aquaporin-1, impairs tumor angiogenesis provides novel insights into the mechanisms governing the neovascularization and growth of tumors.
Clapp
Carmen
C
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, Qro, México 76230. clapp@servidor.unam.mx
Martínez de la Escalera
Gonzalo
G
D000818:Animals; D020346:Aquaporins / Q000378:metabolism / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D042783:Endothelial Cells / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*
D020346:Aquaporins