title: Identification of plant microRNA homologs.
abstract: MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that regulate gene and protein expression in plants and animals. MiRNAs have so far been identified mostly by specific cloning of small RNA molecules, complemented by computational methods. We present a computational identification approach that is able to identify candidate miRNA homologs in any set of sequences, given a query miRNA. The approach is based on a sequence similarity search step followed by a set of structural filters.
authors.affiliation: Center for Bioinformatics Tübingen, Tübingen University, Germany. dezulian@informatik.uni-tuebingen.de
authors.forename: Tobias
authors.initials: T
authors.lastname: Dezulian
authors.forename: Michael
authors.initials: M
authors.lastname: Remmert
authors.forename: Javier F
authors.initials: JF
authors.lastname: Palatnik
authors.forename: Detlef
authors.initials: D
authors.lastname: Weigel
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Huson
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D017124:Conserved Sequence; D035683:MicroRNAs / Q000032:analysis / Q000737:chemistry* / Q000235:genetics*; D008969:Molecular Sequence Data; D009862:Online Systems; D010944:Plants / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs