title: Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis.
abstract: The study of mammalian meiosis is complicated by the timing of meiotic events in females and by the intermingling of meiotic sub-stages with somatic cells in the gonad of both sexes. In addition, studies of mouse mutants for different meiotic regulators have revealed significant differences in the stringency of meiotic events in males versus females. This sexual dimorphism implies that the processes of recombination and homologous chromosome pairing, while being controlled by similar genetic pathways, are subject to different levels of checkpoint control in males and females. This review is focused on the emerging picture of sexual dimorphism exhibited by mammalian germ cells using evidence from the broad range of meiotic mutants now available in the mouse. Many of these mouse mutants display distinct differences in meiotic progression and/or dysfunction in males versus females, and their continued study will allow us to understand the molecular basis for the sex-specific differences observed during prophase I progression.
authors.affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Meisha A
authors.initials: MA
authors.lastname: Morelli
authors.forename: Paula E
authors.initials: PE
authors.lastname: Cohen
mesh_terms: D000818:Animals; D003434:Crossing Over, Genetic; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000166:cytology*; D008297:Male; D008322:Mammals / Q000502:physiology*; D008540:Meiosis / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D012727:Sex Characteristics; D012730:Sex Chromosomes / Q000502:physiology