title: Efficacy of STI571 for a patient with metastatic gastrointestinal stromal tumor.
abstract: A 65-year-old man was referred to our hospital for evaluation of his huge abdominal tumor. He was diagnosed as having a gastrointestinal stromal tumor arising from the stomach. Seven months after surgery, multiple liver metastases and mesenteric dissemination occurred. He was medicated with STI571, which works by blocking proliferation of malignant cells with expression of c-kit. The tumors shrank and serum lactate dehydrogenase and alkaline phosphatase concentrations fell to below the normal limit three months later. STI571 was effective medicine for the metastatic gastrointestinal stromal tumor for six months in this case.
authors.affiliation: Division of Therapeutic Medicine, Department of Internal Medicine, Nagoya University School of Medicine, Japan. ccz18720@hkg.odn.ne.jp
authors.forename: Yoji
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Niwa
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ando
authors.forename: Yasuro
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohmiya
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hirooka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Itoh
authors.forename: Shimako
authors.initials: S
authors.lastname: Furuta
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000368:Aged; D001549:Benzamides; D001707:Biopsy, Needle; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D010166:Palliative Care; D010879:Piperazines / Q000008:administration & dosage*; D011743:Pyrimidines / Q000008:administration & dosage*; D018570:Risk Assessment; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate