title: Photodynamic therapy of genital condylomata in men.
abstract: Current treatments for genital condylomata are not completely satisfactory, as they fail to clear lesions in a proportion of patients, and relapses after successful treatment are frequently seen. Photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA) has been suggested as a novel treatment option. We performed a small open study using topical 5-ALA and red light (630 nm) in nine men with genital condylomata and a history of at least one previous unsuccessful conventional treatment. Complete cure was achieved in three patients, one of whom experienced a relapse after 3 weeks. Three patients showed partial responses, and three showed no response. Based on the currently available evidence, PDT is a viable treatment option for selected cases that fail to respond to other therapies.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Munich, Germany. thomas.herzinger@lrz.uni-muenchen.de
authors.forename: T
authors.initials: T
authors.lastname: Herzinger
authors.forename: R
authors.initials: R
authors.lastname: Wienecke
authors.forename: P
authors.initials: P
authors.lastname: Weisenseel
authors.forename: C
authors.initials: C
authors.lastname: Borelli
authors.forename: C
authors.initials: C
authors.lastname: Berking
authors.forename: K
authors.initials: K
authors.lastname: Degitz
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology; D005832:Genital Diseases, Male / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000622:Aminolevulinic Acid