Synthesis and evaluation of demethoxyviridin derivatives as potential antimicrobials.
The in vitro antibacterial and antifungal activities of demethoxyviridin and some synthetic analogues were evaluated by the agar diffusion method. The minimum inhibitory concentrations (MIC) of the active compounds were also determined by the agar dilution method. Demethoxyviridin (1) showed moderate antibacterial activity against most of the strains tested. 1alpha-Hydroxydemethoxyviridin (3) showed antibacterial activity and the most potent in vitro antifungal activity with MIC of 20 microg/ml (0.062 mM) against Aspergillus niger, A. fumigatus, A. flavus, A. parasiticus, Fusarium solani, F. graminarum, Geotrichum candidum whereas 5'-methylfuro-(4',3',2'-4,5,6)androst-5-ene-3,17-dione (7) exhibited very weak antifungal activity against Candida albicans only.
Kiran
Ismail
I
Department of Chemistry, Faculty of Arts and Science, Osmangazi University, Eskişehir, Turkey. ikiran@ogu.edu.tr
Ilhan
Semra
S
Akar
Tamer
T
Tur
Lacine
L
Erol
Erdinc
E
D000736:Androstenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010740:Phospholipases / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
D000736:Androstenes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; C070594:demethoxyviridin; D010740:Phospholipases