title: New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.
abstract: Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3-16132 Genoa, Italy. schensil@unige.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Schenone
authors.forename: Chiara
authors.initials: C
authors.lastname: Brullo
authors.forename: Olga
authors.initials: O
authors.lastname: Bruno
authors.forename: Francesco
authors.initials: F
authors.lastname: Bondavalli
authors.forename: Angelo
authors.initials: A
authors.lastname: Ranise
authors.forename: Walter
authors.initials: W
authors.lastname: Filippelli
authors.forename: Barbara
authors.initials: B
authors.lastname: Rinaldi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Capuano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Falcone
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D013276:Stomach Ulcer / Q000150:complications; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000577:Amides; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole; D007213:Indomethacin