Molecular/genetic determinants of repolarization and their modification by environmental stress.
Although a variety of factors, inherited or environmental, can influence expression of ion channel proteins to impact on repolarization, that environment can affect genetic determinants of repolarization for intervals of varying duration is a concept that is not as generally appreciated as it should be. In the following pages we review the molecular/genetic determinants of cardiac repolarization and summarize how pathologic events and environmental intrusions can affect these determinants. Understanding the chains of events involved should yield insights into both the causes and potential avenues of treatment for abnormalities of repolarization.
Rosen
M R
MR
Department of Pharmacology, Center for Molecular Therapeutics, College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA. mrr1@columbia.edu
Cohen
I S
IS
D000200:Action Potentials / Q000235:genetics / Q000502:physiology; D000222:Adaptation, Physiological; D000818:Animals; D004562:Electrocardiography; D004777:Environment; D006321:Heart / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008133:Long QT Syndrome / Q000151:congenital / Q000235:genetics / Q000503:physiopathology; D015221:Potassium Channels / Q000235:genetics / Q000502:physiology; D015222:Sodium Channels / Q000235:genetics / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology; D016276:Ventricular Function
D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels