Novel polymorphism in the promoter region of the human nerve growth-factor gene.
We describe a novel T to C transition at position -198 from the transcription start of the human nerve growth-factor (NGF) gene. In British Caucasoid healthy control group that we have genotyped, T and C allele frequencies are 0.633 and 0.367, respectively. This polymorphism affects vitamin D receptor (VDR) binding to its motif in the NGF promoter.
Alam
M
M
Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Pravica
V
V
Fryer
A A
AA
Hawkins
C P
CP
Hutchinson
I V
IV
D000483:Alleles; D005787:Gene Frequency / Q000235:genetics*; D006801:Humans; D020932:Nerve Growth Factor / Q000096:biosynthesis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism; D020218:Response Elements / Q000235:genetics*; D006113:United Kingdom; D044465:White People
D018167:Receptors, Calcitriol; D020932:Nerve Growth Factor