title: Interactions between thrombophilic genetic mutations and clinical bleeding in patients on chronic oral anticoagulant treatment.
abstract: We studied the prevalence of genetic thrombophilic mutations in patients on chronic oral anticoagulant treatment (OAT) who had bleeding complications. In a case-control study we found ten (12.8%) carriers of factor V Leiden and two (2.5%) carriers of the PT20210A mutation among 78 patients with a history of moderate-severe bleeding while on OAT, and seven (4.4%) and four (2.5%), respectively, among 156 matched patients with no bleeding while on OAT (odds ratio 3.1+/-1.6, p=0.026). In patients on chronic OAT, FV Leiden is a risk factor for moderate-severe bleeding.
authors.forename: Luigi
authors.initials: L
authors.lastname: Castori
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Taliani
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Agnelli
authors.forename: Enrico
authors.initials: E
authors.lastname: Boschetti
authors.forename: Paolo
authors.initials: P
authors.lastname: Gresele
mesh_terms: D020413:3' Untranslated Regions; D000074:Acenocoumarol / Q000008:administration & dosage / Q000009:adverse effects; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D005165:Factor V / Q000032:analysis / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D006470:Hemorrhage / Q000139:chemically induced* / Q000235:genetics*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics; D018401:Sample Size; D019851:Thrombophilia / Q000453:epidemiology / Q000235:genetics*; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D020413:3' Untranslated Regions; D000925:Anticoagulants; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V; D011516:Prothrombin; D000074:Acenocoumarol