title: Novel polymorphism in the promoter region of the human nerve growth-factor gene.
abstract: We describe a novel T to C transition at position -198 from the transcription start of the human nerve growth-factor (NGF) gene. In British Caucasoid healthy control group that we have genotyped, T and C allele frequencies are 0.633 and 0.367, respectively. This polymorphism affects vitamin D receptor (VDR) binding to its motif in the NGF promoter.
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: M
authors.initials: M
authors.lastname: Alam
authors.forename: V
authors.initials: V
authors.lastname: Pravica
authors.forename: A A
authors.initials: AA
authors.lastname: Fryer
authors.forename: C P
authors.initials: CP
authors.lastname: Hawkins
authors.forename: I V
authors.initials: IV
authors.lastname: Hutchinson
mesh_terms: D000483:Alleles; D005787:Gene Frequency / Q000235:genetics*; D006801:Humans; D020932:Nerve Growth Factor / Q000096:biosynthesis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism; D020218:Response Elements / Q000235:genetics*; D006113:United Kingdom; D044465:White People
chemical_list: D018167:Receptors, Calcitriol; D020932:Nerve Growth Factor