title: [Initial clinical experience of proton therapy at Shizuoka Cancer Center].
abstract: OBJECTIVE
  To present the initial experience and preliminary clinical results of patients treated mainly with proton irradiation at the newly developed proton therapy facility at Shizuoka Cancer Center.
  
  
  METHODS
  We reviewed 125 patients who underwent proton therapy between July 2003 and December 2004. Of these 125 patients, 11 had head and neck malignancies, 15 non-small cell lung cancers, 22 hepatocellular carcinomas, 62 prostate cancers, and 15 other malignant tumors.
  
  
  RESULTS
  Most patients experienced Grade 0-1 acute morbidities (NCI-CTC) in skin or mucosa, while a temporary Grade 2-3 reaction was observed in a high dose area. Response rates were 73% for H & N malignancies, 100% for NSCLC, and 77% for HCC. PSA evaluation for patients with prostate cancer revealed a high rate of complete response.
  
  
  CONCLUSIONS
  The efficacy and safety of proton therapy at Shizuoka Cancer Center was demonstrated for patients with early-stage cancer or locally advanced disease.
authors.affiliation: Proton Therapy Division, Shizuoka Cancer Center Hospital.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fuji
authors.forename: Haruo
authors.initials: H
authors.lastname: Yamashita
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Futami
authors.forename: Masumi
authors.initials: M
authors.lastname: Numano
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Harada
authors.forename: Minoru
authors.initials: M
authors.lastname: Kamata
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D002173:Cancer Care Facilities; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy; D002648:Child; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy*; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D061766:Proton Therapy; D011878:Radiotherapy / Q000295:instrumentation; D011879:Radiotherapy Dosage; D011522:Protons
chemical_list: D011522:Protons