title: Brain metastases from apocrine carcinoma of the scalp: case report.
abstract: Apocrine carcinoma is an extremely rare malignant neoplasm that occurs most frequently in the axilla. Although it usually shows an indolent clinical course, it often metastasizes to regional lymph nodes and sometimes to lungs or bones. However, a literature search did not reveal any report describing the detailed clinical course of brain metastases from apocrine carcinoma. We report a case of a 54-year-old male who suffered from multiple brain metastases from apocrine carcinoma that had originated in the scalp 6 years before. The brain metastases appeared in spite of several regimens of chemotherapy for lung metastases for two years. The tumor in the right frontal lobe was successfully operated. However, the small tumor in the right occipital lobe was not cured by gamma knife surgery, and eventually required second operation. The operation had contributed to his neurologically independent life for about one year until he died for gradual progression of lung metastases. To our knowledge this is the first reported case of metastatic brain tumor from apocrine carcinoma.
authors.affiliation: Department of Neurosurgery, Nagoya University Graduate School of Medicine, Aichi, Japan. sshimato@med.nagoya-u.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Shimato
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Wakabayashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Mizuno
authors.forename: Norimoto
authors.initials: N
authors.lastname: Nakahara
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hatano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Natsume
authors.forename: Dai
authors.initials: D
authors.lastname: Ishii
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Ikuo
authors.initials: I
authors.lastname: Hyodo
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshida
mesh_terms: D001050:Apocrine Glands / Q000473:pathology*; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery; D002277:Carcinoma / Q000556:secondary* / Q000601:surgery; D017809:Fatal Outcome; D005625:Frontal Lobe / Q000473:pathology / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology / Q000601:surgery; D012535:Scalp / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery