Historical perspective of gastric acid inhibition.
The inhibition of gastric secretion has been a therapeutic objective for decades. A variety of pharmacologic and non-pharmacologic approaches have been proposed throughout history. Among the non-pharmacologic proposals, gastric surgery was widely used until effective drugs were available. Initially antacids and later anticholinergics, H2 blockers and proton pump inhibitors took the predominant position. Finally, Helicobacter pylori eradication has been the milestone for the cure of peptic ulcers.
Díaz-Rubio
Manuel
M
Department of Medical Pathology, Gastroenterology Service, San Carlos Clinical University Hospital, Universidad Complutense, Madrid, Spain. mdiazrubio@sepd.es
D000900:Anti-Bacterial Agents / Q000266:history / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000266:history / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005744:Gastric Acid / Q000378:metabolism; D016481:Helicobacter Infections / Q000188:drug therapy / Q000266:history*; D016480:Helicobacter pylori; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D010437:Peptic Ulcer / Q000266:history* / Q000628:therapy
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents