title: Serum S100beta protein in children with acute recurrent headache: a potentially useful marker for migraine.
abstract: OBJECTIVE
  To examine the role of glia-derived S100beta protein and to evaluate its use as a biochemical marker in childhood acute recurrent headache.
  
  
  METHODS
  Twenty-five patients with acute recurrent headache (according to International Headache Society criteria) from our department's Headache Clinic were studied. Blood samples for measurement of serum S100beta were drawn: (1) < or = 3-hour post pain attack from our patients and (2) from 23 healthy controls.
  
  
  RESULTS
  Of the 25 patients evaluated, 15 suffered from migraine and 10 from tension-type headache (TTH). Statistical analysis of the mean values of S100beta levels demonstrated a significant elevation in children with migraine headache, with values higher than those of both children with TTH and controls (P = .001).
  
  
  CONCLUSIONS
  Our data suggest a direct relation between childhood migraine attacks and increased production of glial S100beta protein. Serum S100beta determination may be a useful biochemical marker for migraine in acute recurrent headache in childhood.
authors.affiliation: First Department of Pediatrics, University of Athens, Goudi, Greece.
authors.forename: Ourania
authors.initials: O
authors.lastname: Papandreou
authors.forename: Alexandra
authors.initials: A
authors.lastname: Soldatou
authors.forename: Artemis
authors.initials: A
authors.lastname: Tsitsika
authors.forename: Catherine
authors.initials: C
authors.lastname: Kariyannis
authors.forename: Thalia
authors.initials: T
authors.lastname: Papandreou
authors.forename: Asimina
authors.initials: A
authors.lastname: Zachariadi
authors.forename: Ioannis
authors.initials: I
authors.lastname: Papassotiriou
authors.forename: George P
authors.initials: GP
authors.lastname: Chrousos
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D015415:Biomarkers; D002648:Child; D005260:Female; D006261:Headache / Q000097:blood*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D011446:Prospective Studies; D012008:Recurrence; D009418:S100 Proteins / Q000097:blood*; D018781:Tension-Type Headache / Q000097:blood
chemical_list: D015415:Biomarkers; D009418:S100 Proteins