Alteration in platelet function in patients with early breast cancer.
The aim of this study was to examine our hypothesis that platelets of patients with breast cancer were functionally altered compared to healthy controls. The results have shown that the platelets from women with early breast cancer released significantly more vascular endothelial growth factor (VEGF) when stimulated with thrombin, tissue factor, clotting, or over a period of time. Similarly, release of thrombospondin (TSP) with thrombin and tissue factor was higher, but failed to reach a significant level. Thus, the observed differences in platelet response support our hypothesis, but warrant further work to determine the reason underlying the observed difference and potential clinical relevance of our findings.
McDowell
G
G
Department of Clinical Biochemistry, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL. garry.mcdowell@manchester.a.uk
Temple
I
I
Li
C
C
Kirwan
C C
CC
Bundred
N J
NJ
McCollum
C N
CN
Burton
I E
IE
Kumar
S
S
Byrne
G J
GJ
D000368:Aged; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D001943:Breast Neoplasms / Q000097:blood*; D002278:Carcinoma in Situ / Q000097:blood; D018270:Carcinoma, Ductal, Breast / Q000097:blood; D002417:Cattle; D006801:Humans; D008875:Middle Aged; D013917:Thrombin / Q000494:pharmacology; D013925:Thromboplastin / Q000494:pharmacology; D019700:Thrombospondin 1 / Q000097:blood / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism
D019700:Thrombospondin 1; D042461:Vascular Endothelial Growth Factor A; D013925:Thromboplastin; D013917:Thrombin