title: Daily intake assessment of saccharin, stevioside, D-sorbitol and aspartame from various processed foods in Korea.
abstract: This study was carried out to estimate the daily intakes (EDIs) of artificial sweeteners such as saccharin, stevioside, D-sorbitol and aspartame in order to evaluate the safety of the artificial sweeteners in Korea. A total of 274 food samples were selected from the foods considered to be representative sources of artificial sweeteners in the Korean diet and analysed by using HPLC with evaporative light scattering and ultraviolet detectors. In case of aspartame, the reference values were used without instrumental analysis. The EDIs of saccharin, stevioside, D-sorbitol and aspartame for average consumers were 0.028, 0.008, 4.9 and 0.14 mg kg-1 body weight day-1, respectively, and as a proportion of the acceptable daily intake (ADI) were not higher than 1% of ADI of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). For 90th percentile consumers, the EDIs of saccharin, stevioside, D-sorbitol and aspartame were 2.0, 0.20, 141 and 4.6 mg kg-1 body weight day-1, respectively, and as a proportion of the ADI, the EDIs of saccharin and aspartame were 40.7% and 11.4% of the ADI set by the JECFA, respectively. Because JECFA did not assign ADIs for stevioside and D-sorbitol, the values for these sweeteners were not compared. According to these results, the EDIs of artificial sweeteners such as saccharin and aspartame in Korea are significantly lower than ADI set by the JECFA.
authors.affiliation: Korea Health Industry Development Institute, 57-1 Noryangjin-Dong, Dongjak-Ku, Seoul, Korea 156-800.
authors.forename: M-S
authors.initials: MS
authors.lastname: Chung
authors.forename: H-J
authors.initials: HJ
authors.lastname: Suh
authors.forename: W
authors.initials: W
authors.lastname: Yoo
authors.forename: S-H
authors.initials: SH
authors.lastname: Choi
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Cho
authors.forename: Y-H
authors.initials: YH
authors.lastname: Cho
authors.forename: C-J
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001218:Aspartame / Q000008:administration & dosage / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004032:Diet / Q000706:statistics & numerical data*; D045786:Diterpenes, Kaurane / Q000008:administration & dosage / Q000032:analysis; D005504:Food Analysis / Q000379:methods; D005960:Glucosides / Q000008:administration & dosage / Q000032:analysis; D006801:Humans; D007223:Infant; D007723:Korea; D008875:Middle Aged; D009749:Nutrition Surveys; D012439:Saccharin / Q000008:administration & dosage / Q000032:analysis; D013012:Sorbitol / Q000008:administration & dosage / Q000032:analysis; D013549:Sweetening Agents / Q000008:administration & dosage* / Q000032:analysis
chemical_list: D045786:Diterpenes, Kaurane; D005960:Glucosides; D013549:Sweetening Agents; C012043:stevioside; D013012:Sorbitol; D012439:Saccharin; D001218:Aspartame