title: The effectiveness of isobutyl cyanoacrylate tissue adhesive for the treatment of corneal perforations.
abstract: OBJECTIVE
  To study the results of treatment of corneal perforations with isobutyl cyanoacrylate tissue adhesive.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  The charts of 20 patients (22 eyes) with corneal perforation <or=3 mm in size treated with isobutyl cyanoacrylate tissue adhesive were reviewed for etiology of perforation, visual outcome, and complications.
  
  
  RESULTS
  Nine of the 22 eyes (40.9%) healed with application of adhesive alone. The mean interval of time needed for healing was 33.4 days. Visual acuity improved in seven eyes (77.8%) and remained stable in two (22.2%). Seven eyes (31.8%) proceeded to penetrating keratoplasty (PK) with the adhesive in place. Of these, visual acuity improved in five (71.4%), remained stable in one (14.3%), and decreased in one (14.3%). Six eyes (27.3%) required more than one application of adhesive.
  
  
  CONCLUSIONS
  Isobutyl cyanoacrylate tissue adhesive is highly effective at treating corneal perforations. Approximately half of the perforations <or=3 mm healed and visual acuity improved in most of these eyes.
authors.affiliation: Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27705, USA.
authors.forename: Daria E
authors.initials: DE
authors.lastname: Setlik
authors.forename: Dianna L
authors.initials: DL
authors.lastname: Seldomridge
authors.forename: Ron A
authors.initials: RA
authors.lastname: Adelman
authors.forename: Terry M
authors.initials: TM
authors.lastname: Semchyshyn
authors.forename: Natalie A
authors.initials: NA
authors.lastname: Afshari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002015:Bucrylate / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012422:Rupture, Spontaneous; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity; D014945:Wound Healing / Q000187:drug effects
chemical_list: D014014:Tissue Adhesives; D002015:Bucrylate