title: Cytochrome c oxidase deficiency in a child with isolated myopathy.
abstract: Cytochrome c oxidase (COX) deficiency is the most commonly recognized respiratory chain defect in childhood. The disease is clinically heterogeneous with phenotypes including Leigh syndrome, hepatic failure and myopathies. COX deficiency has been associated with mitochondrial DNA mutations in COX I, II, and III with large-scale deletions of the mitochondrial genome and with point mutations in mitochondrial tRNA genes. Here we report on a 3.5-year-old girl with a rare type of isolated myopathy due to COX deficiency.
authors.affiliation: Fatih University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey. ahmetkaradag@gmail.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karadag
authors.forename: Zekai
authors.initials: Z
authors.lastname: Avci
authors.forename: Ferhat
authors.initials: F
authors.lastname: Catal
authors.forename: Ender
authors.initials: E
authors.lastname: Odemis
mesh_terms: D002675:Child, Preschool; D030401:Cytochrome-c Oxidase Deficiency / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D009123:Muscle Hypotonia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D014451:Ubiquinone / Q000627:therapeutic use
chemical_list: D014451:Ubiquinone