Towards high-throughput functional target discovery in angiogenesis research.
Angiogenesis is a hallmark of malignancies and other proliferative diseases, and inhibition of this process is considered to be a promising treatment strategy. Classical gene-expression analyses performed during the past decade have generated vast lists of genes associated with disease but have so far yielded only limited novel therapeutic targets for clinical applications. Recently, the focus has shifted from target identification, based on gene-expression analysis, to identification of genes, based on the function of the encoded protein. Disease-target genes can now be identified in a high-throughput fashion based on functional properties that are directly related to the disease phenotype. This new approach significantly shortens the time span for the development of therapeutic applications from the laboratory bench to the hospital bedside.
van Beijnum
Judy R
JR
Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, Maastricht University Hospital, PO Box 5800, 6202AZ Maastricht, The Netherlands.
Eijgelaar
Wouter J
WJ
Griffioen
Arjan W
AW
D000818:Animals; D015870:Gene Expression; D015723:Gene Library; D005821:Genetic Techniques; D023281:Genomics; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000628:therapy; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000627:therapeutic use; D034622:RNA Interference; D012107:Research Design; D014162:Transfection
D016376:Oligonucleotides, Antisense