title: Effects of isoflurane and sevoflurane on the survival of skin flaps in rats.
abstract: The effects of inhalational anaesthetic agents on survival of flaps are not well known. We investigated the effect of isoflurane and sevoflurane anaesthesia on survival of flaps using a caudally-based McFarlane skin flap in 20 male Wistar rats. Sevoflurane 1 minimum alveolar concentration (MAC) and isoflurane (1 MAC) in oxygen mixture was given to the animals. A 4 x10 cm caudally-based standard McFarlane flap was raised. There were no differences in any haemodynamic values or blood gases between the sevoflurane group and the isoflurane group. Skin flaps were assessed on the seventh day. The isoflurane group had a significantly smaller area of skin flap necrosis and an increased area of flap surviving than the sevoflurane group. We conclude that survival is significantly improved when isoflurane is used as the inhalational anaesthetic rather than sevoflurane.
authors.affiliation: Department of Plastic Surgery, Medical Faculty of Selçuk University, Konya, Turkey. ztosun@selcuk.edu.tr
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Tosun
authors.forename: Sema
authors.initials: S
authors.lastname: Tuncer
authors.forename: Alper
authors.initials: A
authors.lastname: Yosunkaya
authors.forename: Adem
authors.initials: A
authors.lastname: Ozkan
authors.forename: Sadik
authors.initials: S
authors.lastname: Sentürk
authors.forename: Nedim
authors.initials: N
authors.lastname: Savaci
mesh_terms: D000758:Anesthesia; D000818:Animals; D062109:Dermatologic Surgical Procedures; D006085:Graft Survival / Q000187:drug effects*; D007530:Isoflurane; D008297:Male; D008738:Methyl Ethers; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D000077149:Sevoflurane; D012867:Skin / Q000098:blood supply*; D016038:Skin Transplantation; D013524:Surgical Flaps / Q000098:blood supply
chemical_list: D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane