Catalytic enantioselective Conia-ene reaction.
An enantioselective intramolecular Conia-ene reaction of beta-dicarbonyl compounds and alkynes to afford methylene cyclopentanes is described. The reaction employs a DTBMSegphos-Pd(II)/Yb(III) dual catalyst system that allows for the asymmetric synthesis of all-carbon quaternary centers and generates a product containing an alkene that can be further manipulated.
Corkey
Britton K
BK
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Toste
F Dean
FD
D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D006571:Heterocyclic Compounds