Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese.
BACKGROUND
Ethnicity and smoking are well-known risk factors for the pathogenesis of coronary vasospasm. Oxidative stress induced by smoking plays a crucial role in coronary vasospasm, but is not enough to account for the pathogenesis of coronary vasospasm, indicating that genetic factors are strongly involved.


RESULTS
The study group comprised 162 vasospastic angina patients (VSAs), 61 microvascular angina patients (MVAs) and 61 non-responders (NRs) diagnosed by acetylcholine provocation test. Four polymorphisms of the oxidative stress related genes, cytochrome b-245, alpha polypeptide gene (CYBA) C242T and A640G, paraoxonase 1 gene (PON1) A632G, phospholipase A2 group VII gene (PLA2G7) G994T were genotyped. Allele frequency of PON1 632-G was significantly higher in both the VSA with dominant fashion and the MVA with recessive fashion compared with NR. This association was strongly influenced by gender in the MVA only. There were no significant associations between the other polymorphisms and coronary vasospasm. In addition, the allele frequency of PON1 632-G in the Japanese was higher than in Caucasians.


CONCLUSIONS
There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese.
Mashiba
Junko
J
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Koike
George
G
Kamiunten
Hitoshi
H
Ikeda
Manami
M
Sunagawa
Kenji
K
D000109:Acetylcholine; D000368:Aged; D000788:Angina Pectoris, Variant / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D003329:Coronary Vasospasm / Q000209:etiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D017720:Molecular Epidemiology; D018384:Oxidative Stress / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000208:ethnology / Q000235:genetics
D043303:Aryldialkylphosphatase; D000109:Acetylcholine