title: The effects of changing exercise levels on weight and age-related weight gain.
abstract: OBJECTIVE
  To determine prospectively whether physical activity can prevent age-related weight gain and whether changing levels of activity affect body weight.
  
  
  METHODS
  The study consisted of 8,080 male and 4,871 female runners who completed two questionnaires an average (+/-standard deviation (s.d.)) of 3.20+/-2.30 and 2.59+/-2.17 years apart, respectively, as part of the National Runners' Health Study.
  
  
  RESULTS
  Changes in running distance were inversely related to changes in men's and women's body mass indices (BMIs) (slope+/-standard error (s.e.): -0.015+/-0.001 and -0.009+/-0.001 kg/m(2) per Deltakm/week, respectively), waist circumferences (-0.030+/-0.002 and -0.022+/-0.005 cm per Deltakm/week, respectively) and percent changes in body weight (-0.062+/-0.003 and -0.041+/-0.003% per Deltakm/week, respectively, all P<0.0001). The regression slopes were significantly steeper (more negative) in men than women for DeltaBMI and Delta%body weight (P<0.0001). A longer history of running diminished the impact of changing running distance on men's weights. When adjusted for Deltakm/week, years of aging in men and years of aging in women were associated with increases of 0.066+/-0.005 and 0.056+/-0.006 kg/m(2) in BMI, respectively, increases of 0.294+/-0.019 and 0.279+/-0.028% in Delta%body weight, respectively, and increases of 0.203+/-0.016 and 0.271+/-0.033 cm in waist circumference, respectively (all P<0.0001). These regression slopes suggest that vigorous exercise may need to increase 4.4 km/week annually in men and 6.2 km/week annually in women to compensate for the expected gain in weight associated with aging (2.7 and 3.9 km/week annually when correct for the attenuation due to measurement error).
  
  
  CONCLUSIONS
  Age-related weight gain occurs even among the most active individuals when exercise is constant. Theoretically, vigorous exercise must increase significantly with age to compensate for the expected gain in weight associated with aging.
authors.affiliation: Lawrence Berkeley Laboratory, Donner Laboratory, Life Sciences Division, Berkeley, CA 94720, USA. ptwilliams@lbl.gov
authors.forename: P T
authors.initials: PT
authors.lastname: Williams
authors.forename: P D
authors.initials: PD
authors.lastname: Wood
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000886:Anthropometry; D001824:Body Constitution / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012420:Running / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology*