title: Prevention of undesirable isomerization during olefin metathesis.
abstract: 1,4-Benzoquinones have been found to prevent olefin isomerization of a number of allylic ethers and long-chain aliphatic alkenes during ruthenium-catalyzed olefin metathesis reactions. Electron-deficient benzoquinones are the most effective additives for the prevention of olefin migration. This mild, inexpensive, and effective method to block olefin isomerization increases the synthetic utility of olefin metathesis via improvement of overall product yield and purity.
authors.affiliation: Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
authors.forename: Soon Hyeok
authors.initials: SH
authors.lastname: Hong
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Sanders
authors.forename: Choon Woo
authors.initials: CW
authors.lastname: Lee
authors.forename: Robert H
authors.initials: RH
authors.lastname: Grubbs