Role of iron-ATP complex in lymphocyte proliferation and infiltration.
The roles of sodium-ATP (NaATP) and ferric-ATP complex (FeATP) on the proliferation and infiltration of lymphocytes have been studied by evaluation of the hypertrophy and histopathologic examination of spleen and liver, as well of the modifications in the elemental balance of iron, calcium, magnesium, and phosphorus. The results showed that in the implicated biochemical processes, calcium and magnesium have a principal role. An in vitro study on a cell model has permited one to evaluate the effects of deferoxamine, a known iron chelator and inhibitor of human lymphocyte proliferation, on FeATP-modified cellular calcium fluxes. These findings showing a reduced 45Ca2+ uptake in the presence of deferoxamine appear to indicate that in vivo the chelation of blood-borne iron by ATP might play a key role in proliferation and infiltration of lymphocytes, leading to lymphoma development.
Anghileri
Leopold J
LJ
Biophysics Laboratory, Medicine Faculty, Nancy University, France. leopoldo.anghileri@wanadoo.fr
Ortal
Emilio Mayayo
EM
Thouvenot
Pierre
P
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D003676:Deferoxamine / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008223:Lymphoma / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D051379:Mice; D010758:Phosphorus / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D007502:Iron Chelating Agents; D010758:Phosphorus; D000255:Adenosine Triphosphate; D007501:Iron; D008274:Magnesium; D003676:Deferoxamine; D002118:Calcium