title: Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour.
abstract: Drug-induced spoliation of hydrogels as contact lenses or as implants in the anterior eye is a frequent occurrence in clinical practice. This study explores the capacity of three commercial multipurpose solutions for contact lens care to reduce the spoliation of poly(2-hydroxyethyl methacrylate) (PHEMA) specimens exposed to a simulated aqueous humour formulation and to three topical drugs commonly administered after insertion of artificial corneas (Predsol, Optimol and Depo-Ralovera). ReNu MultiPlus (Bausch & Lomb), Complete Blink-N-Cleantrade mark Lens Drops (Allergan) and Complete Protein Remover Tablets dissolved in Complete ComfortPLUS (both from Allergan) were evaluated. All multipurpose solutions were able to dislodge passively the deposits formed on hydrogels in the simulated aqueous and in the presence of Predsol and Optimol, but none were effective against the deposits induced by Depo-Ralovera. A reduction of the calcium content in deposits caused by Predsol and Optimol was confirmed after treatment with the protein remover preparation, while the other multipurpose solutions caused the complete removal of the deposits. In experiments designed to evaluate the preventive action of the multipurpose solutions, no such effects were observed regardless of the drug involved. The prospect of using multipurpose solutions as eye drops following implantation of a hydrogel artificial cornea is a valid alternative for reducing device spoliation, however it appears to depend on the nature of the postoperative medication.
authors.affiliation: Department of Biomaterials and Polymer Research, Lions Eye Institute, and Centre for Ophthalmology and Visual Science, University of Western Australia, 2 Verdun Street, Nedlands 6009, WA, Australia. tchirila@cyllene.uwa.edu.au
authors.forename: Traian V
authors.initials: TV
authors.lastname: Chirila
authors.forename: David A
authors.initials: DA
authors.lastname: Morrison
authors.forename: Zoya
authors.initials: Z
authors.lastname: Gridneva
authors.forename: Danielle
authors.initials: D
authors.lastname: Meyrick
authors.forename: Celia R
authors.initials: CR
authors.lastname: Hicks
authors.forename: John M
authors.initials: JM
authors.lastname: Webb
mesh_terms: D001082:Aqueous Humor / Q000502:physiology*; D002118:Calcium / Q000032:analysis; D018639:Contact Lens Solutions / Q000494:pharmacology*; D004355:Drug Stability; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D011239:Prednisolone / Q000031:analogs & derivatives / Q000494:pharmacology; D013999:Timolol / Q000494:pharmacology
chemical_list: D018639:Contact Lens Solutions; D011102:Polyhydroxyethyl Methacrylate; C009022:prednisolone phosphate; D013999:Timolol; D011239:Prednisolone; D017258:Medroxyprogesterone Acetate; D002118:Calcium