title: Some molecular aspects in schistosomiasis mansoni and toxoplasmosis.
abstract: The IL-2 and IL-4 cytokines production represent cellular Th1 & Th2 immune responses respectively were associated with chronic schistosomiasis mansoni (stages 1-4) and chronic toxoplasmosis gondii. In the hepatosplenic schistosomiasis, the level of IL-2 and disease stage increased in parallel (P<0.05, <0.01, <0.01 & <0.001 in stages 1, 2, 3 & 4 respectively), whereas, IL-4 was highly significantly increased in stage 1 than control (P<0.001), then decreased to lower levels. The mean concentrations of IL-2 & IL-4 in patients with T. gondii were higher compared to control being more marked in IL-2 (P<0.001) versus IL-4 (P< 0.01). The data indicated that there are patterns of cytokine expression characteristic of type 1 & type 2 responses in vivo, with the ultimate goal of being able to manipulate the response to minimize inflammation and fibrosis for clinical benefit.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Mansoura University, Mansoura.
authors.forename: Atef M
authors.initials: AM
authors.lastname: el-Shazly
authors.forename: Manar S
authors.initials: MS
authors.lastname: Azab
authors.forename: Samar N
authors.initials: SN
authors.lastname: el-Beshbishi
authors.forename: Hala A
authors.initials: HA
authors.lastname: el-Nahas
authors.forename: Aida A
authors.initials: AA
authors.lastname: Abdel Magied
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abou el-Hasan
authors.forename: M el-Salahy M M
authors.initials: Mel-S
authors.lastname: Monib
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000097:blood; D015847:Interleukin-4 / Q000096:biosynthesis / Q000097:blood; D008297:Male; D012555:Schistosomiasis mansoni / Q000276:immunology*; D012720:Severity of Illness Index; D014123:Toxoplasmosis / Q000276:immunology*
chemical_list: D007376:Interleukin-2; D015847:Interleukin-4