Radiotherapy in the treatment of dermatofibrosarcoma protuberans.
OBJECTIVE
To evaluate the role of postoperative radiotherapy (RT) for patients with dermatofibrosarcoma protuberans (DFSP).


METHODS
Ten patients were treated with surgery and postoperative RT and had follow-up from 21 to 185 months. Nine patients had DFSP and 1 patient had a fibrosarcomatous component (DFSP-FS). No patient had gross disease at the time of RT.


RESULTS
Nine patients with DFSP remained disease free after surgery and postoperative RT. The patient with DFSP-FS experienced a local recurrence after surgery, external beam RT, and a brachytherapy boost, and died with disease. There were no severe complications.


CONCLUSIONS
Postoperative RT may reduce the risk of local recurrence in patients with DFSP who have a high risk of residual disease after surgery.
Dagan
Roi
R
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
Morris
Christopher G
CG
Zlotecki
Robert A
RA
Scarborough
Mark T
MT
Mendenhall
William M
WM
D000328:Adult; D001918:Brachytherapy; D018223:Dermatofibrosarcoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control / Q000532:radiotherapy; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012535:Scalp; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D016896:Treatment Outcome