title: Potentiation of GABA-activated currents by imidazobenzoimidazole derivative RU-353 in isolated cerebellum Purkinje cells.
abstract: Voltage clamp and concentration jump experiments performed on Purkinje cells isolated from rat cerebellum showed that novel imidazobenzoimidazole derivative RU-353 increased the amplitude of GABA-activated chlorine current in a dose-dependent manner (EC50=15 microM for the currents activated by 1 microM GABA). RU-353 shifted the GABA dose-response curve to the left, but produced no effect on the maximum response (EC50 in control and in the presence of 30 microM RU-353 were 6.9 and 2.0 microM, respectively).
authors.affiliation: Brain Research Institute, Russian Academy of Medical Sciences, Moscow.
authors.forename: N I
authors.initials: NI
authors.lastname: Sharonova
authors.forename: V S
authors.initials: VS
authors.lastname: Vorob'ev
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitskii
authors.forename: A P
authors.initials: AP
authors.lastname: Galenko-Yaroshevskii
authors.forename: A Yu
authors.initials: AY
authors.lastname: Turovaya
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D004357:Drug Synergism; D058785:GABA-A Receptor Agonists; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D011689:Purkinje Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D001562:Benzimidazoles; D058785:GABA-A Receptor Agonists; D007473:Ion Channels; C507880:RU 353; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid