title: Role of ketoprofen in the modulation of hyperalgesia associated with lameness in dairy cattle.
abstract: Forty lame dairy cows were randomly assigned to receive a course of either the non-steroidal anti-inflammatory drug ketoprofen, or sterile saline, together with conventional treatment for lameness. The effect of the ketoprofen was measured by using locomotion scoring and by testing the cows' nociceptive threshold over a period of 28 days. The locomotion score of all the cows improved but ketoprofen had no significant effect on this change. However, in the cows that received ketoprofen the hyperalgesia associated with lameness, recorded using a nociceptive threshold test, was significantly modulated on days 3, 8 and 28 after their initial examination, drug administration and treatment of lesions.
authors.affiliation: Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Whay
authors.forename: A J F
authors.initials: AJ
authors.lastname: Webster
authors.forename: A E
authors.initials: AE
authors.lastname: Waterman-Pearson
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005534:Foot Diseases / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary; D006930:Hyperalgesia / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D007660:Ketoprofen / Q000494:pharmacology* / Q000627:therapeutic use; D007794:Lameness, Animal / Q000188:drug therapy* / Q000473:pathology; D008124:Locomotion; D009619:Nociceptors / Q000187:drug effects; D017288:Pain Threshold; D011897:Random Allocation; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen