title: Are vanadium compounds drugable? Structures and effects of antidiabetic vanadium compounds: a critical review.
abstract: Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Autónoma de Puebla, Av. 14 Sur y Av. San Claudio, Col, San Manuel, Puebla, Pue, México. tscior@siu.buap.mx
authors.forename: Thomas
authors.initials: T
authors.lastname: Scior
authors.forename: Antonio
authors.initials: A
authors.lastname: Guevara-García
authors.forename: Philippe
authors.initials: P
authors.lastname: Bernard
authors.forename: Quoc-Tuan
authors.initials: QT
authors.lastname: Do
authors.forename: David
authors.initials: D
authors.lastname: Domeyer
authors.forename: Stefan
authors.initials: S
authors.lastname: Laufer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017968:Vanadium Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D002614:Chelating Agents; D007004:Hypoglycemic Agents; D017968:Vanadium Compounds