[The role of EPR-1 in proliferation and apoptosis in nasopharyngeal carcinoma].
OBJECTIVE
To investigate the relationship between the expression of effector cell protease receptor-1 (EPR-1) of coagulation serine protease factor Xa, proliferative index (Pi) ki-67 and apoptotic index (AI) in nasopharyngeal carcinoma.


METHODS
Using immunohistochemical S-P staining and terminal deoxynucleotidyl transferase mediate dUTP nick and labeling (TUNEL) technique, the expression of EPR-1, ki-67 and AI was detected in the paraffin-embedded specimens including 42 nasopharyngeal carcinoma tissues, 42 normal nasopharyngeal tissues adjacent to the tumors tissues and 30 chronic nasopharyngitis tissues.


RESULTS
The positive rate of EPR-1 expression in the NPC tissues, normal nasopharyngeal tissues adjacent to the tumors and chronic nasopharyngeal tissues was 76.1%, 90.5%,100.0%, respectively. EPR-1 was positively correlated with AI and negatively with ki-67.


CONCLUSIONS
EPR-1 play a role in increase the apoptosis and decrease the proliferation of cell. These suggest that EPR-1 may be a potential therapy for NPC.
He
Ning
N
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Kong
Weijia
W
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D000077022:Survivin; D055815:Young Adult
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D011956:Receptors, Cell Surface; D000077022:Survivin