[Indications of GnRH analogues before and after surgery for endometriosis].
Indications of GnRH analogues before and/or after surgery for endometriosis remain controversial. Although some studies have underlined a decrease in rAFS scores using GnRH analogues pre-operatively, data are insufficient to recommend their systematic use in routine. In the same way, despite an increase in symptom free period subsequent to the use of GnRH analogues post-operatively, no effect of this therapeutic on recurrence rate and fertility outcome has been proved. In addition to a meta-analysis on GnRH analogues in endometriotic women, further studies, especially in women with large endometriomas and with deep pelvic endometriosis, are required to clarify the indications of GnRH analogues associated with surgical management.
Daraï
E
E
Service de gynécologie-obstétrique, hôpital Tenon, UFR Saint-Antoine, université Paris-VI, France. emile.darai@tnn.ap-hop-paris.fr
Dubernard
G
G
Azoulay
C
C
Barranger
E
E
Antoine
J-M
JM
Uzan
S
S
D004715:Endometriosis / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D011182:Postoperative Care; D011300:Preoperative Care
D007987:Gonadotropin-Releasing Hormone