title: [Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population].
abstract: OBJECTIVE
  To investigate the association between genetic variations in methylenetetrahydrofolate reductase (MTHFR) and the risk of colorectal cancer in a Chinese population.
  
  
  METHODS
  One hundred and ninety-eight cases of colorectal cancer and 420 controls were genotyped for detecting MTHFR C677T and A1298C polymorphisms by PCR-RFLP methods. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by using unconditional logistic regression model.
  
  
  RESULTS
  The frequency of the MTHFR C677T allele found among cases was significantly more frequent than that among controls (51.3% to 44.4%, P = 0.02). As compared with the 677CC genotype, the 677TT genotypes had a 67% (95% CI, 1.05 - 2.66) increased risk of colorectal cancers. However, there appeared no any correlations between the genetic variations of MTHFR and the cancer metastasis.
  
  
  CONCLUSIONS
  These findings demonstrated that the genetic variation of MTHFR C677T should be a genetic susceptibility factor for colorectal cancer in a Chinese population.
authors.affiliation: Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Miao
authors.forename: Shen
authors.initials: S
authors.lastname: Yang
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Ying-jiang
authors.initials: YJ
authors.lastname: Ye
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Lin
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)