title: [Free radical scavenger and lipid peroxidation inhibiting effects of medicinal plants used in phytotherapy].
abstract: Epidemiological and clinical studies have proved the beneficial effect of bioactive compounds of vegetables and medicinal plants used in phytotherapy on prevention of several diseases. Beyond the well-known natural antioxidants, such as vitamins, other natural substances can function as antioxidants. In 1992 the Saas Fee Declaration was published by leader nutritionist and biochemists underlining the importance of prevention in health maintenance based on scientific studies with natural compounds. According to the declaration the antioxidants are the main active and beneficial components. Authors joining with the spirit of Saas Fee Declaration have worked out a complex examination system to study the antioxidant, free radical scavenging and inhibitory effects on lipid peroxidation of isolated components, natural plant extracts and herbal preparations. The members of the system are the followings: hydrogendonating ability, reducing power, chelating activity, free radical scavenging activities measured by chemiluminescence techniques, electron paramagnetic resonance / spin trapping studies, inhibition of lipid peroxidation induced in rat brain / liver microsomes, consequencies and treatment of experimental hyperlipidemia, morphological and histological studies. Only one measurement cannot give enough information about the antioxidant properties of the products. Complex in vitro examination of a novel antioxidant can draw pictures of correlation between the chemical structure and antioxidant effect, the mechanism of its favourable effect and its presumable role in prevention of lipid peroxidation. With the use of these results planning and execution of in vivo examinations should be more precise, practical and essential.
authors.affiliation: Semmelweis Egyetem, Farmakognózia Intézet, Budapest, Ulloi fit 26. - 1085.
authors.forename: Agnes
authors.initials: A
authors.lastname: Kéry
authors.forename: Andrea
authors.initials: A
authors.lastname: Lugasi
authors.forename: Andrea
authors.initials: A
authors.lastname: Balázs
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Fehér
authors.forename: László
authors.initials: L
authors.lastname: Prónai
authors.forename: Erika
authors.initials: E
authors.lastname: Czinner
authors.forename: Krisztina
authors.initials: K
authors.lastname: Hagymási
authors.forename: Pál
authors.initials: P
authors.lastname: Apáti
authors.forename: Ildikó
authors.initials: I
authors.lastname: Papp
authors.forename: Barbara
authors.initials: B
authors.lastname: Hevesi-Tóth
authors.forename: Anna
authors.initials: A
authors.lastname: Blázovics
mesh_terms: D000975:Antioxidants; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation; D008517:Phytotherapy; D010946:Plants, Medicinal; D014675:Vegetables; D014815:Vitamins
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D014815:Vitamins