title: [Corticotropic axis and chronic stress in abdominal obesity and metabolic syndrome].
abstract: Several indicators of corticotropic axis hyperactivity have been observed in common abdominal obesity, which is clinically similar to the obesity found in Cushing's syndrome. Corticotropic axis hyperactivity may be involved in the development and metabolic and cardiovascular complications of abdominal obesity. Several mechanisms may be responsible for this hormonal dysregulation: genetic, lifestyle, and nutritional factors, and chronic stress. We note the necessity of methodologically-impeccable clinical studies for an objective evaluation of the role of stress in obesity.
authors.affiliation: Service d'endocrinologie, des maladies métaboliques et de la nutrition, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille, Marseille (13).
authors.forename: S
authors.initials: S
authors.lastname: Boullu-Ciocca
authors.forename: P
authors.initials: P
authors.lastname: Verger
authors.forename: A
authors.initials: A
authors.lastname: Bocquier
authors.forename: C
authors.initials: C
authors.lastname: Oliver
mesh_terms: D050153:Abdominal Fat; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D002908:Chronic Disease; D020022:Genetic Predisposition to Disease; D006801:Humans; D008019:Life Style; D024821:Metabolic Syndrome / Q000503:physiopathology* / Q000523:psychology*; D009752:Nutritional Status; D012307:Risk Factors; D013315:Stress, Psychological
chemical_list: D000324:Adrenocorticotropic Hormone