title: Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for cutaneous melanoma.
abstract: Susceptibility to solar ultraviolet is an important melanoma risk factor. We investigated the relationship between individual susceptibility to ultraviolet and risk of melanoma by measuring the apoptosis triggered in peripheral lymphocytes by a low-dose ultraviolet B irradiation (50 J/m(2)) in young and older melanoma patients and controls. Melanoma patients below the age of 40 are more sensitive to UVB-induced apoptosis than older melanoma patients and healthy controls. Analysis of data (adjusted for age and phototype) shows that UVB-induced apoptosis is an important risk factor for melanoma (OR 9.1, 95% CI [3-28], P=0.0001). UVB-induced apoptosis is independent of phototype (P=0.11, Wald test) and tumour thickness (P=0.88, Spearman correlation, for all cases and 0.26 for patients younger than 40 years), and may be used as a functional laboratory test for studying the genetic-environment interactions involved in melanoma occurrence.
authors.affiliation: INSERM U 590, Lyon, France. remy.pedeux@ujf-grenoble.fr
authors.forename: Rémy
authors.initials: R
authors.lastname: Pedeux
authors.forename: François
authors.initials: F
authors.lastname: Sales
authors.forename: Julie
authors.initials: J
authors.lastname: Pourchet
authors.forename: Mireille
authors.initials: M
authors.lastname: Kallassy
authors.forename: Caroline
authors.initials: C
authors.lastname: Fayolle
authors.forename: Mathieu
authors.initials: M
authors.lastname: Boniol
authors.forename: Gianluca
authors.initials: G
authors.lastname: Severi
authors.forename: Ghanem
authors.initials: G
authors.lastname: Ghanem
authors.forename: Hisayoshi Nym
authors.initials: HN
authors.lastname: Nakazawa
authors.forename: Philippe
authors.initials: P
authors.lastname: Autier
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Doré
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000528:radiation effects; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008545:Melanoma / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*