title: [Two case reports on intra-tumor injection therapy of dendritic cells].
abstract: DC (dendritic cells) vaccine therapy against cancer has attracted attention in recent years. However, the existence of the immunosuppressive state in cancer individuals leads to anergy and failure in cytotoxic T cell (CTL) induction and DC migration to the target organ. It has been reported that injected intra-tumor DC is expected to work phagocytosis of the tumor as a localized effect, the consequent CTL induction in the tumor and the regional lymphnodes, resulting in a systemic effect. Two cases reported in this article were performed with intra-tumor DC injection therapy by means of EUS (endoscopic ultrasonography) which indicated interesting immunoreaction.
authors.affiliation: Dept. of Surgery II, Fukushima Medical University.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoshihara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abel
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Endoh
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Onogi
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohki
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takita
authors.forename: Kouji
authors.initials: K
authors.lastname: Sekikawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takenoshita
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Takagi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Satoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
mesh_terms: D000368:Aged; D002465:Cell Movement / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology*; D004938:Esophageal Neoplasms / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D015552:Injections, Intralesional; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D018227:Sarcoma, Clear Cell / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology