T Cell Immunity and Aging.
The effect of age on the immune system is generally detrimental and results in "immunosenescence," a poorly-defined state inadequately reflected in clinical data and for which few reliable "biomarkers of aging" are available. The multinational consortium "T-Cell Immunity in Ageing," T-CIA, was set up to examine these issues specifically as applied to T lymphocytes. This Perspective discusses some of the outcomes of a recent conference that considered progress toward resolving these questions in humans.
Koch
Sven Dominik
SD
Center for Medical Research, University of Tuebingen, D-72072 Tuebingen, Germany. sven-dominik.koch@student.uni-tuebingen.de
Kempf
Juergen
J
Pawelec
Graham
G
D000375:Aging / Q000235:genetics / Q000276:immunology*; D000941:Antigens; D004249:DNA Damage; D004260:DNA Repair; D023281:Genomics; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D040901:Proteomics; D013601:T-Lymphocytes / Q000502:physiology*
D000941:Antigens; D006360:Heat-Shock Proteins