title: Complications after breast cancer surgery in patients treated with concomitant preoperative chemoradiation: A case-control analysis.
abstract: BACKGROUND
  Nearly 60% of breast cancer cases in Mexico are in advanced stages. At our institution, concomitant preoperative chemoradiation is being used in patients with advanced breast cancer. In the present study, we evaluated the postoperative wound complications and risk factors associated.
  
  
  METHODS
  The study included breast cancer patients from January 2000 to December 2002 treated with concomitant preoperative chemoradiation and mastectomy. Wound complication rates were described along with a nested case-control analysis to evaluate risk factors for postoperative major wound complications.
  
  
  RESULTS
  We evaluated 360 patients treated with preoperative chemoradiation. About 165 patients (45.8%) developed a wound complication (infection and/or flap necrosis); 60 (16.6%) patients had a surgical site infection (SSI) and 61 (16.9%), flap necrosis; 44 (12.2%) developed both complications, and 25 (6.9%) experienced late dehiscence after suture removal. Epidermolysis, seroma, and hematoma occurred in 93 (25.8%), 80 (22.2%), and 12 patients (3.3%), respectively. Case-control analysis was conducted in 335 patients. After logistic regression analysis, the sole variable found associated with SSI and/or flap necrosis was epidermolysis (OR = 8.81, 95% CI = 4.52-17.18). Although not significant and of lesser magnitude, adjusted risk estimates of overweight, age >50 years, and type of mastectomy showed the same trend.
  
  
  CONCLUSIONS
  Postoperative wound complications were not different from those observed in non-radiated patients, but its rate was higher. Epidermolysis was associated with SSI and/or flap necrosis. Careful surgical technique should be encouraged.
authors.affiliation: Breast Tumor Department, Instituto Nacional de Cancerología, Mexico City, México.
authors.forename: Eva
authors.initials: E
authors.lastname: Ruvalcaba-Limón
authors.forename: Carlos
authors.initials: C
authors.lastname: Robles-Vidal
authors.forename: Adela
authors.initials: A
authors.lastname: Poitevin-Chacón
authors.forename: Mariana
authors.initials: M
authors.lastname: Chávez-Macgregor
authors.forename: Carlos
authors.initials: C
authors.lastname: Gamboa-Vignolle
authors.forename: Diana
authors.initials: D
authors.lastname: Vilar-Compte
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008408:Mastectomy / Q000009:adverse effects*; D008875:Middle Aged; D009336:Necrosis; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D012871:Skin Diseases / Q000209:etiology*; D013524:Surgical Flaps; D014945:Wound Healing
chemical_list: D000970:Antineoplastic Agents