Synthesis of deserpidine from reserpine.
The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.
Varchi
Greta
G
Istituto CNR per la Sintesi Organica e Fotoreattività ISOF, Area della Ricerca di Bologna, Via P., Gobetti 101, 40129 Bologna, Italy. G.Varchi@isof.cnr.it
Battaglia
Arturo
A
Samorì
Cristian
C
Baldelli
Eleonora
E
Danieli
Bruno
B
Fontana
Gabriele
G
Guerrini
Andrea
A
Bombardelli
Ezio
E
D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011926:Rauwolfia / Q000737:chemistry; D012110:Reserpine / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D012110:Reserpine; C100104:deserpidine