title: An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci.
abstract: Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate species in biomedical research. To create new opportunities for genetic and genomic studies using rhesus monkeys, we constructed a genetic linkage map of the rhesus genome. This map consists of 241 microsatellite loci, all previously mapped in the human genome. These polymorphisms were genotyped in five pedigrees of rhesus monkeys totaling 865 animals. The resulting linkage map covers 2048 cM including all 20 rhesus autosomes, with average spacing between markers of 9.3 cM. Average heterozygosity among those markers is 0.73. This linkage map provides new comparative information concerning locus order and interlocus distances in humans and rhesus monkeys. The map will facilitate whole-genome linkage screens to locate quantitative trait loci (QTLs) that influence individual variation in phenotypic traits related to basic primate anatomy, physiology, and behavior, as well as QTLs relevant to risk factors for human disease.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, 7620 N.W., Loop 410, San Antonio, TX 78227, USA. jrodgers@darwin.sfbr.org
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rogers
authors.forename: Roy
authors.initials: R
authors.lastname: Garcia
authors.forename: Wendy
authors.initials: W
authors.lastname: Shelledy
authors.forename: Jordan
authors.initials: J
authors.lastname: Kaplan
authors.forename: Ann
authors.initials: A
authors.lastname: Arya
authors.forename: Zach
authors.initials: Z
authors.lastname: Johnson
authors.forename: Mackenzie
authors.initials: M
authors.lastname: Bergstrom
authors.forename: Leilah
authors.initials: L
authors.lastname: Novakowski
authors.forename: Prakash
authors.initials: P
authors.lastname: Nair
authors.forename: Amanda
authors.initials: A
authors.lastname: Vinson
authors.forename: Deborah
authors.initials: D
authors.lastname: Newman
authors.forename: Gary
authors.initials: G
authors.lastname: Heckman
authors.forename: Judy
authors.initials: J
authors.lastname: Cameron
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000379:methods; D008040:Genetic Linkage; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*