title: Periurethral granuloma following injection with dextranomer/hyaluronic acid copolymer for stress urinary incontinence.
abstract: Periurethral injection of bulk-enhancing agents provides a simpler and cost-effective therapeutic approach for stress incontinence in women. We report a case of periurethral granuloma secondary to dextranomer/hyaluronic acid (Dx/HA) copolymer injection. A 73-year-old woman with history of radiotherapy for cervical carcinoma at the age of 55 presented with stress urinary incontinence. She underwent periurethral injection of Dx/HA copolymer, and incontinence was resolved. At 4 months postoperatively, a 3-4 cm noninflammatory painless mass in the external genitalia was noted. Cystic images compatible with urethral diverticula were seen in the magnetic resonance imaging scan, but voiding cystourethrography was unrevealing. Transvaginal tumor puncture yielded abundant creamy material, the culture of which was negative. Microscopic examination revealed refractile foreign material surrounded by foreign body giant cells. Surgical debridement of the granuloma using a cold scalpel was performed. Stress urinary incontinence recurred but resolved spontaneously within 1 month. One year later, the patient continues to be asymptomatic.
authors.affiliation: Service of Obstetrics and Gynecology, Hospital Universitari del Mar, Universitat Autònoma de Barcelona, Passeig Marítim 25-29, 08003 Barcelona, Spain.
authors.forename: María-Teresa
authors.initials: MT
authors.lastname: Castillo-Vico
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Checa-Vizcaíno
authors.forename: Antonio
authors.initials: A
authors.lastname: Payà-Panadés
authors.forename: Carolina
authors.initials: C
authors.lastname: Rueda-García
authors.forename: Ramón
authors.initials: R
authors.lastname: Carreras-Collado
mesh_terms: D000368:Aged; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D007267:Injections; D008279:Magnetic Resonance Imaging; D014522:Urethral Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D014550:Urinary Incontinence, Stress / Q000188:drug therapy*
chemical_list: D003911:Dextrans; C487487:dextranomer-hyaluronic acid copolymer; D006820:Hyaluronic Acid