Formal syntheses of (+/-)-pinnaic acid and (+/-)-halichlorine.
[chemical reaction: see text]. Concise formal syntheses of marine alkaloids (+/-)-pinnaic acid (1) and (+/-)-halichlorine (2) have been accomplished from a common intermediate. The syntheses illustrate the utility of selective olefin cross metathesis methodologies for the elaboration of advanced synthetic intermediates in complex molecule synthesis.
Andrade
Rodrigo B
RB
Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.
Martin
Stephen F
SF
D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000470:Alkaloids; D013141:Spiro Compounds; C412666:halichlorine; C412665:pinnaic acid