title: Giant cell tumor of soft tissue with pulmonary metastases: pathologic and cytogenetic study.
abstract: Giant cell tumor of soft tissue (GCTST) has gained general acceptance as an uncommon but distinct primary soft tissue tumor since it was first described in 1972. GCTST is predominantly seen in adults and typically shows uniformly dispersed osteoclast-like giant cells admixed with oval to polygonal mononuclear cells. It usually follows a benign clinical course, although the malignant variant has been described in cases in which the mononuclear cells demonstrate obvious dysplastic features. It is still not clear whether the two variants belong to the spectrum of the same tumor. No cytogenetic chromosomal abnormalities have been reported in the literature of GCTST. Interestingly, the osseous counterpart of giant cell tumor, which shares similar histologic features, quite often displays a telomeric association at the cytogenetic level, a finding that has never been reported in GCTST. We report the case of a 12-year-old girl with GCTST of the right leg that metastasized to the lung. Cytogenetic studies from the primary tumor showed the phenomenon of telomeric association involving multiple chromosomes.
authors.affiliation: Department of Pathology, Division of Pediatric Pathology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Garcia
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Perle
authors.forename: John
authors.initials: J
authors.lastname: Amodio
authors.forename: M Alba
authors.initials: MA
authors.lastname: Greco
mesh_terms: D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D005870:Giant Cell Tumors / Q000235:genetics* / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology*; D016615:Telomere / Q000235:genetics