title: Episodic memory-related activation in schizophrenia: meta-analysis.
abstract: BACKGROUND
  Numerous studies have examined the neural correlates of episodic memory deficits in schizophrenia, yielding both consistencies and discrepancies in the reported patterns of results.
  
  
  OBJECTIVE
  To identify in schizophrenia the brain regions in which activity is consistently abnormal across imaging studies of memory.
  
  
  METHODS
  Data from 18 studies meeting the inclusion criteria were combined using a recently developed quantitative meta-analytic approach.
  
  
  RESULTS
  Regions of consistent differential activation between groups were observed in the left inferior prefrontal cortex, medial temporal cortex bilaterally, left cerebellum, and in other prefrontal and temporal lobe regions. Subsequent analyses explored memory encoding and retrieval separately and identified between-group differences in specific prefrontal and medial temporal lobe regions.
  
  
  CONCLUSIONS
  Beneath the apparent heterogeneity of published findings on schizophrenia and memory, a consistent and robust pattern of group differences is observed as a function of memory processes.
authors.affiliation: Brain Imaging Group, Douglas Hospital Research Centre-FBCI, 6875 Boulevard LaSalle, Verdun, Québec H4H 1R3, Canada.
authors.forename: Amélie M
authors.initials: AM
authors.lastname: Achim
authors.forename: Martin
authors.initials: M
authors.lastname: Lepage
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008568:Memory / Q000502:physiology*; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D014057:Tomography, X-Ray Computed / Q000379:methods