title: Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons.
abstract: Sequencing studies of the glycoprotein G gene were performed in human respiratory syncytial virus (hRSV) strains detected by reverse-transcription polymerase chain reaction directly from nasopharyngeal aspirates of hospitalized children < or =3 years old over 2 winters. Clinical data were compared between 106 children infected with group A hRSV (96 GA2 genotypes) and 94 children infected with hRSV group B (62 GB3 genotypes). A severity index was defined by assigning 1 point each for the use of >30% supplemental oxygen, admission to an intensive-care unit, and duration of hospital stay of >5 days. Group A and genotype GA2 strains were associated with greater severity of hRSV disease than were group B strains.
authors.affiliation: Laval University, Quebec, Canada. rodica.gilca@ssss.gouv.qc.ca
authors.forename: Rodica
authors.initials: R
authors.lastname: Gilca
authors.forename: Gaston
authors.initials: G
authors.lastname: De Serres
authors.forename: Mireille
authors.initials: M
authors.lastname: Tremblay
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Vachon
authors.forename: Eric
authors.initials: E
authors.lastname: Leblanc
authors.forename: Michel G
authors.initials: MG
authors.lastname: Bergeron
authors.forename: Pierre
authors.initials: P
authors.lastname: Dery
authors.forename: Guy
authors.initials: G
authors.lastname: Boivin
mesh_terms: D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D008297:Male; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D012621:Seasons; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D014760:Viral Fusion Proteins / Q000235:genetics
chemical_list: C502275:G glycoprotein, Respiratory syncytial virus; D014760:Viral Fusion Proteins