[Expression of topoisomerase III alpha in epithelial ovarian tumors of different types and relation between the expression of topoisomerase III alpha and the clinical pathology of tumor].
OBJECTIVE
To investigate the expression status of topoisomerase IIIa in epithelial ovarian tumor and the relationship between the expression status of topoisomerase IIIa and pathological type and clinical stage of epithelial ovarian carcinoma.


METHODS
Immunohistochemistry was carried out in the samples of ovarian tumor obtained during operation from 169 patients, aged 28 approximately 59, 18 cases with serous cystadenoma, 30 cases with serous borderline cystadenoma, 37 serous cystadenocarcinoma, 10 cases with mucous cystadenoma, 20 mucous borderline cystadenoma, 26 mucous cystadenocarcinoma, 19 cases with endometrial carcinoma of ovary, and 9 cases with clear cell carcinoma.


RESULTS
The expression rate of topoisomerase IIIa was 17.9% in the benign ovarian tumors, 74.0% in the borderline cystadenoma, and 42.7% in the malignant tumors with statistical significance among them (chi(2) = 24.657, P < 0.001). There was no correlation between the expression of topoisomerase IIIa and the clinical stage or pathological grade of the tumors (P = 0.903 and P = 0.844).


CONCLUSIONS
Topoisomerase IIIa is highly expressed in epithelial ovarian carcinoma, and its expression level is correlated with the character and type of tumor tissues.
Zhang
Wen-ying
WY
Hospital No.306 of People's Liberation Army, Beijing 100101, China.
Pan
Ying
Y
Zhu
Li-rong
LR
Zhang
Jian-zhong
JZ
Zhang
Ming
M
Feng
Kai
K
Zhou
Ling
L
Yu
Li
L
Zhang
Xiao-mei
XM
Ng
Shu-wing
SW
D000328:Adult; D018291:Cystadenoma, Mucinous / Q000201:enzymology / Q000473:pathology; D018293:Cystadenoma, Serous / Q000201:enzymology / Q000473:pathology; D004264:DNA Topoisomerases, Type I / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000096:biosynthesis; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000473:pathology
D007527:Isoenzymes; D004264:DNA Topoisomerases, Type I