title: Antibody levels and protection to canine parvovirus type 2.
abstract: The relationship between maternally derived antibody (MDA) levels and protection to canine parvovirus (CPV) infection in pups is reported. Twelve pups with a wide range of haemagglutination inhibiting (HI) titres of MDA to CPV were divided into four groups, with each group balanced for antibody titres. The dogs were inoculated with a field CPV-2b strain and clinical signs, virus shedding and antibody response were assessed. The CPV was not detected in the faeces of dogs with HI titres of 320 at any time. In dogs with HI titres up to 160, active CPV replication after challenge was demonstrated by real-time polymerase chain reaction. The successful infection of dogs with HI titres of 80 and 160 was confirmed by seroconversion, evaluated at day 14 post-infection. These findings demonstrated that CPV infection could also occur in the presence of MDA HI titres (> or =80) usually considered fully protective.
authors.affiliation: Department of Animal Health and Well-Being, Faculty of Veterinary Medicine of Bari, Strada per Casamassima Km 3, 70010 Valenzano (Bari), Italy. g.elia@veterinaria.uniba.it
authors.forename: G
authors.initials: G
authors.lastname: Elia
authors.forename: A
authors.initials: A
authors.lastname: Cavalli
authors.forename: F
authors.initials: F
authors.lastname: Cirone
authors.forename: E
authors.initials: E
authors.lastname: Lorusso
authors.forename: M
authors.initials: M
authors.lastname: Camero
authors.forename: D
authors.initials: D
authors.lastname: Buonavoglia
authors.forename: M
authors.initials: M
authors.lastname: Tempesta
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000276:immunology; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D010322:Parvoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines