[A metabolic function of the lungs in postoperative changes of vascular regulation in patients with occlusive lesions of the abdominal aorta and major arteries of the lower limbs].
OBJECTIVE
To study a pathogenetic role of endogenous biologically active substances (EBAS) in the development of a vascular response and EBAS metabolism in the lungs of patients with surgical vascular pathology.


METHODS
Content of serotonin, histamine, epinephrine, prostaglandins, cyclic nucleotides were studied in 84 patients with occlusive lesions of the abdominal aorta and major arteries before and after reconstructive surgery.


RESULTS
The greatest changes in concentrations of EBAS and their metabolism in the lungs were observed in an immediate postoperative period in patients with baseline arterial hypertension and without it. These changes reflected initial disorders of normal relations of EBAS and influence of perioperative factors. Periods of aortal cross-clamping and blood recirculation in ischemic limbs were key factors of critical activation of the systems of humoral circulation regulation.


CONCLUSIONS
Quantitative and qualitative changes in EBAS balance lead to enhancement of peripheral resistance and development of arterial hypertension.
Nazyrova
L A
LA
D000368:Aged; D001012:Aorta, Abdominal / Q000473:pathology* / Q000601:surgery; D001157:Arterial Occlusive Diseases / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D001158:Arteries / Q000473:pathology* / Q000601:surgery; D001794:Blood Pressure / Q000502:physiology; D004837:Epinephrine / Q000032:analysis; D006632:Histamine / Q000032:analysis; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000032:analysis; D009712:Nucleotides, Cyclic / Q000032:analysis; D011184:Postoperative Period; D011453:Prostaglandins / Q000032:analysis; D012701:Serotonin / Q000032:analysis; D013050:Spectrometry, Fluorescence
D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D012701:Serotonin; D006632:Histamine; D009638:Norepinephrine; D004837:Epinephrine