title: Prevalence of MDS subtypes in Shanghai, China: a comparison of the World Health Organization and French American British classifications.
abstract: The prevalence of subtypes of the myelodysplastic syndromes (MDS) was determined in a prospective series of 176 patients presenting at 28 Shanghai hospitals. Diagnosis was established in a single laboratory, analyzing morphologic, immunophenotypic, and cytogenetic data, using the World Health Organization (WHO) revised classification and directly compared to the French American British (FAB) criteria. The median age at diagnosis for all cases was 53 years. There was a striking increase in the prevalence of RCMD in younger patients relative to other subtypes (WHO). The overall frequency of clonal cytogenetic abnormalities was 26.5% (WHO) and 31% (FAB). The most frequently encountered lesions were trisomy 8, del(20)q, del(7q), and del(5q). These results are consistent with previously reported age-dependent differences in MDS and a decreased frequency of del(5q) abnormalities between China and the West. These results also indicate that multilineage dysplasia is a prominent feature in MDS developing in younger individuals in Shanghai and suggest distinguishing between RCMD and RA may be important in the design of studies to further understand regional differences in subtype prevalence and to elucidate the pathogenesis of this complex and multifactorial disease.
authors.affiliation: Sino-US Joint Clinical and Molecular Laboratory, Fudan University, Shanghai, China. richard.irons@uchsc.edu
authors.forename: Richard D
authors.initials: RD
authors.lastname: Irons
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Wang
authors.forename: Sherilyn A
authors.initials: SA
authors.lastname: Gross
authors.forename: Liming
authors.initials: L
authors.lastname: Bao
authors.forename: John
authors.initials: J
authors.lastname: Ryder
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Hengjuan
authors.initials: H
authors.lastname: Sun
authors.forename: Jue
authors.initials: J
authors.lastname: Zhou
authors.forename: Meirong
authors.initials: M
authors.lastname: Ji
authors.forename: Xinyu
authors.initials: X
authors.lastname: Du
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
authors.forename: Guowei
authors.initials: G
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D002681:China / Q000453:epidemiology; D020732:Cytogenetic Analysis / Q000379:methods; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012680:Sensitivity and Specificity; D014944:World Health Organization