Multicomponent domino reaction from beta-ketoamides: highly efficient access to original polyfunctionalized 2,6-diazabicyclo[2.2.2]octane cores.
We describe a new multicomponent domino reaction from beta-ketoamides, involved as substrates and as nucleophilic partners. We obtain highly functionalized and original 2,6-diazabicyclo[2.2.2]octane cores (2,6-DABCO) in a five-step one-pot sequence, which is fast, environmentally friendly, operationally simple to manage, and combines step- and atom-economic aspects.
Liéby-Muller
Frédéric
F
Université Paul Cézanne (Aix-Marseille III), CNRS UMR 6178, SYMBIO, Faculté des Sciences et Techniques, Case D12-13397, Marseille Cedex 20, France.
Constantieux
Thierry
T
Rodriguez
Jean
J