title: Quality-of-life improvements in cataract patients with bilateral blue light-filtering intraocular lenses: clinical trial.
abstract: OBJECTIVE
  To compare change in patient-reported vision-related and health-related functioning and quality of life (HRQOL) following bilateral implantation with a new blue light-filtering intraocular lens (IOL) with the results of a similar IOL that does not filter blue light.
  
  
  METHODS
  Six clinical sites in the United States.
  
  
  METHODS
  Patients were from 6 clinical sites in the United States that performed a high volume of cataract surgeries. The HRQOL assessments occurred via telephone while patients were at home. Patients requiring bilateral cataract extraction were randomly assigned to 1 of the 2 IOL groups for the first eye. The second eye was later implanted with the same type of IOL. Patients and HRQOL data collectors were treatment-masked, but investigators could not be. Health-related functioning and quality of life was measured with the 39-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-39) and 12-item Short Form Health Survey (SF-12). Assessments were at baseline before implantation in the first eye and 30 to 60 days and 120 to 180 days after implantation of the lens in the second eye.
  
  
  RESULTS
  Both IOL types improved most aspects of patients' HRQOL including color vision and driving. The largest gains occurred on the VFQ composite, general vision, near activities, distance activities, driving, mental health, peripheral vision, and role difficulties scales. Significant gains also occurred on color vision and other vision-specific scales as well as the SF-12 physical component summary score. There were no significant differences in HRQOL gains between the IOLs.
  
  
  CONCLUSIONS
  The blue light-filtering IOL improved color vision, driving, and other aspects of HRQOL in a manner similar to that of a lens that does not filter blue light.
authors.affiliation: Mapi Values, Boston, Massachusetts, USA. derek.espindle@mapivalues.com
authors.forename: Derek
authors.initials: D
authors.lastname: Espindle
authors.forename: Bruce
authors.initials: B
authors.lastname: Crawford
authors.forename: Andrew
authors.initials: A
authors.lastname: Maxwell
authors.forename: Krithika
authors.initials: K
authors.lastname: Rajagopalan
authors.forename: Rod
authors.initials: R
authors.lastname: Barnes
authors.forename: Blake
authors.initials: B
authors.lastname: Harris
authors.forename: Kendra
authors.initials: K
authors.lastname: Hileman
mesh_terms: D000368:Aged; D001334:Automobile Driving; D002386:Cataract / Q000503:physiopathology* / Q000523:psychology; D002387:Cataract Extraction; D003116:Color; D003118:Color Perception; D004867:Equipment Design; D005260:Female; D005374:Filtration; D006304:Health Status; D006801:Humans; D007910:Lenses, Intraocular; D008027:Light; D008297:Male; D008603:Mental Health; D011788:Quality of Life; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D014785:Vision, Ocular