[Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri].
The main pharmacological constituents of Chinese traditional medicine herb Cnidium monnieri are coumarin compounds and volatile oil. In addition, it contains monoterpene polyols, glucides, as well as recently discovered sesquiterpene components. In recent years, rather active investigations of its anti-tumor were performed at home and abroad. C. monnieri possesses multi-aspect and comprehensive anti-tumor functions, involving directly tumor-inhibitory activity, anti-mutagenicity, reversing multi-drug tolerance of tumor, as well as improving immune functions and so on. In this review, chemical constituents, anti-tumor activities and relevant investigations of Fructus Cnidii were summarized recent decade.
Zhou
Ze-wei
ZW
Chinese Academy of Medical Sciences, Tradiation Medica Institute, Tianjin 300192, China. zhouzewei666@yahoo.com.cn
Liu
Pei-xun
PX
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D031048:Cnidium / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; C030123:coumarin; C031534:imperatorin; C046627:osthol