HFE-codon 63/282 (H63D/C282Y) gene variants in Mexican Mestizos are not risk factors for leukemia.
BACKGROUND
In some Caucasian populations it has been found that the C282Y hemochromatosis (HFE) gene mutation is a risk factor for the development of leukemia and other malignancies.


METHODS
In a group of 50 Mexican mestizo patients and 153 normal controls, the HFE gene mutations H63D and C282Y were studied by means of ARMS-PCR.


RESULTS
In the group of patients with leukemia we found a heterozygote for the C282Y mutation, seven heterozygotes for the H63D mutation, a double heterozygote for the H63D / C282Y mutation and 41 normal homozygotes. These data are not different from those observed in normal controls, where the allele frequencies were 0.062 and 0.013 for the H63D and C282Y HFE gene mutations, respectively.


CONCLUSIONS
These HFE gene mutations are not risk factors for the development of leukemia in Mexican mestizos.
Ruiz-Argüelles
Guillermo J
GJ
Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico; Laboratorios Clínicos de Puebla, Puebla, Mexico. gruiz1@clinicaruiz.com
Morales-Toquero
Amelia
A
Cruz-Domínguez
Grethel
G
Reyes-Núñez
Virginia
V
López-Martínez
Briceida
B
Ruiz-Delgado
Guillermo J
GJ
Garcés-Eisele
Javier
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019943:Amino Acid Substitution; D002648:Child; D002675:Child, Preschool; D003062:Codon / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008800:Mexico; D008875:Middle Aged; D017354:Point Mutation; D012307:Risk Factors
D003062:Codon; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins