title: Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion.
abstract: OBJECTIVE
  Neurologic deficits are common after the Norwood procedure for hypoplastic left heart syndrome. Because of the association of deep hypothermic circulatory arrest with adverse neurologic outcome, regional low-flow cerebral perfusion has been used to limit the period of intraoperative brain ischemia. To evaluate the effect of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion.
  
  
  METHODS
  Twenty-two term neonates with hypoplastic left heart syndrome were studied with brain magnetic resonance imaging before and at a median of 9.5 days after the Norwood operation. Results were compared with preoperative, intraoperative, and postoperative risk factors to identify predictors of neurologic injury.
  
  
  RESULTS
  Preoperative magnetic resonance imaging (n = 22) demonstrated ischemic lesions in 23% of patients. Postoperative magnetic resonance imaging (n = 15) demonstrated new or worsened ischemic lesions in 73% of patients, with periventricular leukomalacia and focal ischemic lesions occurring most commonly. Prolonged low postoperative cerebral oximetry (<45% for >180 minutes) was associated with the development of new or worsened ischemia on postoperative magnetic resonance imaging (P = .029).
  
  
  CONCLUSIONS
  Ischemic lesions occur commonly in neonates with hypoplastic left heart syndrome before surgical intervention. Despite the adoption of regional cerebral perfusion, postoperative cerebral ischemic lesions are frequent, occurring in the majority of infants after the Norwood operation. Long-term follow-up is necessary to assess the functional effect of these lesions.
authors.affiliation: Department of Pediatrics, Division of Cardiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA. catherine.dent@cchmc.org
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Dent
authors.forename: James P
authors.initials: JP
authors.lastname: Spaeth
authors.forename: Blaise V
authors.initials: BV
authors.lastname: Jones
authors.forename: Steven M
authors.initials: SM
authors.lastname: Schwartz
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Glauser
authors.forename: Barbara
authors.initials: B
authors.lastname: Hallinan
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Pearl
authors.forename: Philip R
authors.initials: PR
authors.lastname: Khoury
authors.forename: C Dean
authors.initials: CD
authors.lastname: Kurth
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000601:surgery*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care; D012307:Risk Factors