Photodynamic therapy of genital condylomata in men.
Current treatments for genital condylomata are not completely satisfactory, as they fail to clear lesions in a proportion of patients, and relapses after successful treatment are frequently seen. Photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA) has been suggested as a novel treatment option. We performed a small open study using topical 5-ALA and red light (630 nm) in nine men with genital condylomata and a history of at least one previous unsuccessful conventional treatment. Complete cure was achieved in three patients, one of whom experienced a relapse after 3 weeks. Three patients showed partial responses, and three showed no response. Based on the currently available evidence, PDT is a viable treatment option for selected cases that fail to respond to other therapies.
Herzinger
T
T
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Munich, Germany. thomas.herzinger@lrz.uni-muenchen.de
Wienecke
R
R
Weisenseel
P
P
Borelli
C
C
Berking
C
C
Degitz
K
K
D000287:Administration, Topical; D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology; D005832:Genital Diseases, Male / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D012008:Recurrence; D016896:Treatment Outcome
D000622:Aminolevulinic Acid