Distribution of CIAPIN1 in normal fetal and adult human tissues.
CIAPIN1, a newly identified antiapoptotic molecule that plays an essential role in mouse definitive hematopoiesis, is considered a downstream effector of the receptor tyrosine kinase-Ras signaling pathway. Our previous studies have indicated that CIAPIN1 is involved in the development of multidrug resistance (MDR) in gastric cancer cells. However, the mechanism of CIAPIN1-mediated antiapoptosis and MDR has not been fully elucidated. To reveal the possible physiological role of CIAPIN1, we examined the expression and distribution of CIAPIN1 in fetal and adult human tissues using immunohistochemistry. We found that CIAPIN1 was ubiquitously distributed in fetal and adult tissues, and was localized in both the cytoplasm and the nucleus. The expression patterns of CIAPIN1 were similar in fetal and adult tissues, and was correlated with the previously described expression pattern of p21ras. These observations suggest that CIAPIN1 expression appears to be involved in cell differentiation, and that it might exert universal and possibly important physiological functions under the regulation of Ras in humans.
Hao
Zhiming
Z
State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032 Shaanxi Province, China.
Li
Xiaohua
X
Qiao
Taidong
T
Zhang
Jing
J
Shao
Xiaodong
X
Fan
Daiming
D
D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal; D002460:Cell Line; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D046888:Tissue Array Analysis
D000911:Antibodies, Monoclonal; C489114:CIAPIN1 protein, human; D047908:Intracellular Signaling Peptides and Proteins