Increase in slow afterhyperpolarization led to learning delay in DBA mice.
We showed that differences in learning capacity between DBA and C57Bl/6 mice correlates with differences in slow afterhyperpolarization amplitude in hippocampal CA1 pyramid neurons. In DBA mice learning capacity is lower, but the amplitude of slow afterhyperpolarizations higher than in C57Bl/6 mice.
Oksman
G Y
GY
Memorypharm Pharmacological Company, New Jersey, USA.
Li
K
K
Rose
G
G
Skrebitsky
V G
VG
Fedorov
N B
NB
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004924:Escape Reaction; D006624:Hippocampus / Q000502:physiology; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008564:Membrane Potentials; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009435:Synaptic Transmission