Role of Cu2+ in free radical oxidation of human serum albumin and L-tyrosine dipeptide with multicomponent metal-containing xenobiotic.
Cu(2+) entering the composition of multicomponent metal-containing xenobiotic in vitro initiated free radical oxidation of human serum albumin and L-tyrosine dipeptide. Oxidative modification was accompanied by the formation of derivatives of amino acids tyrosine and tryptophan and structural changes in human serum albumin.
Tkachev
S V
SV
Department of Toxicology, Republican Research-and-Technology Center of Hygiene, Minsk. sergtk@rambler.ru
Ushkov
A A
AA
D003300:Copper / Q000737:chemistry*; D019327:Copper Sulfate / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry*; D006801:Humans; D008670:Metals / Q000737:chemistry*; D010084:Oxidation-Reduction; D012709:Serum Albumin / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014364:Tryptophan / Q000737:chemistry; D015262:Xenobiotics / Q000737:chemistry*
D004151:Dipeptides; D005609:Free Radicals; D008670:Metals; D012709:Serum Albumin; D015262:Xenobiotics; C042696:tyrosyltyrosine; D003300:Copper; D014364:Tryptophan; D019327:Copper Sulfate