title: Membranes are more mosaic than fluid.
abstract: The wealth of new data on membrane protein structures and functions is changing our general view of membrane architecture. Some of the key themes that are emerging are that membranes are patchy, with segregated regions of structure and function, that lipid regions vary in thickness and composition, and that crowding and ectodomains limit exposure of lipid to the adjacent aqueous regions.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, Box 208114, New Haven, Connecticut 06520-8114, USA. don@mail.csb.yale.edu
authors.forename: Donald M
authors.initials: DM
authors.lastname: Engelman
mesh_terms: D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008560:Membrane Fluidity / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular
chemical_list: D008051:Lipid Bilayers; D008563:Membrane Lipids; D008565:Membrane Proteins