title: Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.
abstract: Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain. However, it is not known whether inflammation leads to the upregulation of NR2B receptors in these regions. Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC). In freely moving mice, the increase in NR2B receptors after inflammation contributed to enhanced NMDA receptor-mediated responses in the ACC. Inhibition of NR2B receptors in the ACC selectively reduced behavioral sensitization related to inflammation. Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada.
authors.forename: Long-Jun
authors.initials: LJ
authors.lastname: Wu
authors.forename: Hiroki
authors.initials: H
authors.lastname: Toyoda
authors.forename: Ming-Gao
authors.initials: MG
authors.lastname: Zhao
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Lee
authors.forename: Jianrong
authors.initials: J
authors.lastname: Tang
authors.forename: Shanelle W
authors.initials: SW
authors.lastname: Ko
authors.forename: Yong Heng
authors.initials: YH
authors.lastname: Jia
authors.forename: Fanny W F
authors.initials: FW
authors.lastname: Shum
authors.forename: Celina V
authors.initials: CV
authors.lastname: Zerbinatti
authors.forename: Guojun
authors.initials: G
authors.lastname: Bu
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.forename: Tian-Le
authors.initials: TL
authors.lastname: Xu
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Muglia
authors.forename: Zhou-Feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Yves P
authors.initials: YP
authors.lastname: Auberson
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D019706:Excitatory Postsynaptic Potentials; D005620:Freund's Adjuvant; D006179:Gyrus Cinguli / Q000378:metabolism* / Q000503:physiopathology; D006930:Hyperalgesia / Q000209:etiology* / Q000523:psychology; D007249:Inflammation / Q000139:chemically induced / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009619:Nociceptors / Q000503:physiopathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013569:Synapses; D009435:Synaptic Transmission; D015854:Up-Regulation
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate; D005620:Freund's Adjuvant