Safety of statins: effects on muscle and the liver.
Although statin drugs can have adverse effects on muscles and the liver, these effects are uncommon. Caution is warranted in patients at higher risk, ie, those who are elderly, frail, or small; have multisystem disease; are receiving immunosuppressive drugs or other medications that interact with statins; or are receiving higher doses of a statin.
Vasudevan
Abu R
AR
Division of Endocrinology and Metabolism, Center for Cardiovascular Disease Prevention, Lipid and Atherosclerosis Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Hamirani
Yasmin S
YS
Jones
Peter H
PH
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology; D008148:Lovastatin / Q000009:adverse effects* / Q000627:therapeutic use; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein; D008148:Lovastatin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase