Density functional theory study of the hydrogen bond interaction between lactones, lactams, and methanol.
The structure and relative stability of methanol complexes with various cyclic ketones, lactones, lactams, and N-methyl lactams from three- to seven-membered rings have been investigated using the density functional theory method. The geometries, harmonic frequencies, and energies were calculated at the B3LYP/6-311+G(d,p) level. Three stable structures, cis-a, cis-b, and trans, with respect to the ring oxygen (nitrogen) atom, were found to be local minima of the potential energy surface. For lactones and N-methyl lactams, the most stable structure is trans; it is stabilized, as in cyclic ketones, through the conventional hydrogen bond (HB) interaction between the basic carbonyl oxygen and the acidic methanolic hydrogen and an unconventional HB interaction between the methanolic oxygen and the CH hydrogen, in the alpha position of the carbonyl group. For unsubstituted lactams, the cis-a structure, stabilized through a HB interaction between the NH group and the methanol oxygen in addition to the conventional HB interaction, is the most stable. The topological properties of the electron density ratify the existence of conventional (N,O-H. . .O) and unconventional (C-H. . .O) hydrogen bonding. A good correlation was found between the HB distances and the electron density at the HB critical point. The unsubstituted lactams yield more stable complexes with methanol than N-methyl lactams, lactones, and cyclic ketones. In the most stable complexes, both components behave simultaneously as a HB donor and as a HB acceptor.
El Firdoussi
A
A
Département de Chimie Faculté des Sciences Semlalia, Université Cadi Ayyad, Marrakesh, Morocco, Instituto de Quimica Fisica Rocasolano, CSIC, Serrano, 119, E-28006 Madrid, Spain.
Esseffar
M
M
Bouab
W
W
Abboud
J-L M
JL
Mó
O
O
Yáñez
M
M
Ruasse
M F
MF
D003500:Cyclization; D004583:Electrons; D006860:Hydrogen Bonding; D007659:Ketones / Q000737:chemistry; D007769:Lactams / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013816:Thermodynamics; D014732:Vibration
D007659:Ketones; D007769:Lactams; D007783:Lactones; D000432:Methanol