title: Impact of perinatal weight change on long-term obesity and obesity-related illnesses.
abstract: OBJECTIVE
  To estimate the impact of perinatal weight change on obesity, weight gain, and development of obesity-related illnesses 15 years after pregnancy.
  
  
  METHODS
  Pregnancy-related factors and weights of 795 women were recorded at first prenatal visit and 6 months postpartum and were available through medical record review at 4, 10, and 15 years. Obesity-related illnesses were recorded 15 years later.
  
  
  RESULTS
  A total of 484 (61%) original cohort members were available for follow-up. Weight gain during pregnancy, weight loss by 6 months postpartum, and baseline body mass index (BMI) were all related to current BMI and weight gain at follow-up. Women who breastfed beyond 12 weeks and participated in postpartum aerobic exercise had lower BMI and weight gain 15 years later. By follow-up, 13% had developed diabetes or prediabetes. Thirty percent had developed heart disease, hypertension, or dyslipidemia. Baseline BMI and weight change over 15 years were significant predictors of both diseases. Smoking status at last follow-up was also a significant predictor of heart disease or pre-heart disease.
  
  
  CONCLUSIONS
  Excess pregnancy weight gain and failure to lose weight in an appreciable time are indicators of obesity in midlife. Excess weight gain and obesity status are predictors of diabetes and heart disease, although pregnancy-related weight changes alone are not directly related.
authors.affiliation: Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601, USA. blrooney@gundluth.org
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Rooney
authors.forename: Charles W
authors.initials: CW
authors.lastname: Schauberger
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Mathiason
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D016001:Confidence Intervals; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000175:diagnosis* / Q000453:epidemiology*; D010298:Parity; D018743:Perinatal Care; D049590:Postpartum Period; D011247:Pregnancy / Q000502:physiology*; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D013997:Time Factors