[Radioguided occult breast lesion location (ROLL)].
OBJECTIVE
To obtain correct location of occult breast lesions by radiopharmaceutical methods.


METHODS
Sixty-one patients whose ages ranged from 32 to 83 years (average: 57), with non-palpable breast lesions detected by mammography were studied. Six of them had a background of previous breast cancer. Sixty-three lesions were found. The lesions were classified into 34 clusters of microcalcifications, 25 nodules and 4 others parenchymal distortions. All patients received one dose of 0.3-0.5 mCi (11.1-18.5 MBq) of macroaggregates of 99mTc-labelled human serum albumin (99mTc-MAA) into the lesion under stereotactic mammographic or ultrasonography guidance. Anterior and lateral scintigraphic images were acquired in order to verify the correct location of the radiopharmaceutical. Intraoperative location of the lesion was performed using a gammaprobe. In case of microcalcifications, the entire removal of the lesion was verified by X-ray of the specimen.


RESULTS
Placement of the radiotracer was good in 60 of 63 (95.2%) cases. Sixty-one lesions were completely removed. Pathological examination revealed 29 (47.6%) breast cancers and 32 (52.4%) benign lesions.


CONCLUSIONS
Radioguided occult breast lesion location by radiopharmaceutical methods is a simple, safe and well-tolerated method by patients.
Cortés Romera
M
M
Servicio de Medicina Nuclear, Complejo Hospitalario de Ciudad Real, Ciudad Real. mcortesr@sescam.jccm.es
Pardo García
R
R
Soriano Castrejón
A
A
García Vicente
A
A
Ruiz Díaz
M
M
Poblete García
V M
VM
Carbajo Vicente
M
M
Rodado Marina
S
S
Ruiz Solís
S
S
Talavera Rubio
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000000981:diagnostic imaging* / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D002114:Calcinosis / Q000000981:diagnostic imaging; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D005348:Fibrocystic Breast Disease / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D015552:Injections, Intralesional; D008327:Mammography; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging; D015642:Radiology, Interventional / Q000295:instrumentation / Q000379:methods*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D013238:Stereotaxic Techniques; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage; D014463:Ultrasonography
D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin