title: Differences in risk factors for lower extremity arterial occlusive disease.
abstract: BACKGROUND
  Patients undergoing lower extremity revascularization have associated cardiovascular risks: smoking, hypertension, dyslipidemia, and diabetes. This study evaluated the impact of cardiovascular risk factors on proximal versus distal arterial occlusive disease in patients undergoing lower extremity revascularization as adjusted to a control group without vascular disease.
  
  
  METHODS
  We performed a retrospective, case-control study that included 151 patients undergoing lower extremity revascularization and 229 patients undergoing knee and hip replacement (controls). Risk factors were determined for each of three separate groups undergoing revascularization for different levels of occlusive disease: aortoiliac, superficial femoral, and popliteal-tibial. Comparisons to controls were tested using t-tests or chi-square tests and multiple logistic regression.
  
  
  RESULTS
  Dyslipidemia was associated with a significant risk of aortoiliac (odds ratio [OR]=3.4; p=0.0006) and superficial femoral occlusion (OR=2.8; p=0.01) but was less strongly associated with popliteal-tibial occlusion (OR=2.1; p=0.09). Smoking was strongly associated with aortoiliac (OR=4.5; p=0.004) and superficial femoral disease (OR=4.6; p=0.0007) but not popliteal-tibial disease (OR=1.3; p=0.53). In contrast, diabetes mellitus and chronic renal insufficiency were strong risk factors for popliteal-tibial occlusion (OR=5.4, p=0.0002; OR=3.9, p=0.01, respectively), but were not significant risk factors for aortoiliac or superficial femoral occlusion.
  
  
  CONCLUSIONS
  These data, which use revascularization level as a surrogate marker for lower extremity arterial disease, suggest that the risk factor profile for proximal disease differs from that of distal disease. These findings may reflect differences in the biology of disease and indicate that different risk factors have various anatomic influences on arterial disease formation.
authors.affiliation: Department of Surgery, VA Boston Healthcare System, West Roxbury, MA 02132, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Raffetto
authors.forename: Jana E
authors.initials: JE
authors.lastname: Montgomery
authors.forename: Robert T
authors.initials: RT
authors.lastname: Eberhardt
authors.forename: Wayne W
authors.initials: WW
authors.lastname: LaMorte
authors.forename: James O
authors.initials: JO
authors.lastname: Menzoian
mesh_terms: D001157:Arterial Occlusive Diseases / Q000453:epidemiology* / Q000601:surgery; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology