B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.
This chapter will review the scenario of normal B cell development--from the decision of a lymphoid progenitor to enter the B-lineage, over the stages of the generation of the repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature B cells to develop memory and plasma cells--highlighting some of the cellular stages and the molecular mechanisms that can generate and select transformed states of cells. The scenarios for pre-B lymphoma (lymphocytic leukaemia) development are discussed in more detail.
Melchers
F
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Department of Cell Biology, Biozentrum of the University of Basel, Switzerland. fritz.melchers@unibas.ch
D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D015851:Interleukin-7 / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000235:genetics / Q000276:immunology; D051379:Mice; D009154:Mutation; D051757:PAX5 Transcription Factor / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000378:metabolism*; D020395:Receptors, Interleukin-7 / Q000378:metabolism; D015398:Signal Transduction
D015851:Interleukin-7; D051757:PAX5 Transcription Factor; C497282:Pax5 protein, mouse; D011947:Receptors, Antigen, B-Cell; D020395:Receptors, Interleukin-7