title: Haemophagocytic syndrome associated with hepatitis-B virus infection responding to etoposide.
abstract: Haemophagocytic syndrome (HPS) secondary to viral infections usually has a variable course and can be life-threatening. We report a 53-year-old male patient who presented with fever, hepatosplenomegaly and pancytopenia. He had deranged liver function, abnormal clotting and markedly elevated serum ferritin. Bone marrow biopsy showed prominent haemophagocytosis. The patient was investigated thoroughly and found to have evidence of chronic hepatitis B-virus (HBV) infection by serological tests and liver biopsy. Other conditions associated with HPS such as lymphoma, malignancy and other viral or bacterial infections were not present. The patient did not respond to steroids, intravenous immunoglobulins or cyclosporin but responded to etoposide and became apyrexial. He also became HBV negative on lamivudine. The patient died of infection later on but there was no evidence of recurrence of HPS. To the best of our knowledge this is the first case report of HPS associated with isolated HBV infection.
authors.affiliation: Division of Haematology/Oncology, Department of Medicine, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia. aameraleem@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Aleem
authors.forename: S
authors.initials: S
authors.lastname: Al Amoudi
authors.forename: S
authors.initials: S
authors.lastname: Al-Mashhadani
authors.forename: N
authors.initials: N
authors.lastname: Siddiqui
mesh_terms: D005047:Etoposide / Q000627:therapeutic use*; D017809:Fatal Outcome; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D019259:Lamivudine; D005047:Etoposide