Efficacy of STI571 for a patient with metastatic gastrointestinal stromal tumor.
A 65-year-old man was referred to our hospital for evaluation of his huge abdominal tumor. He was diagnosed as having a gastrointestinal stromal tumor arising from the stomach. Seven months after surgery, multiple liver metastases and mesenteric dissemination occurred. He was medicated with STI571, which works by blocking proliferation of malignant cells with expression of c-kit. The tumors shrank and serum lactate dehydrogenase and alkaline phosphatase concentrations fell to below the normal limit three months later. STI571 was effective medicine for the metastatic gastrointestinal stromal tumor for six months in this case.
Sasaki
Yoji
Y
Division of Therapeutic Medicine, Department of Internal Medicine, Nagoya University School of Medicine, Japan. ccz18720@hkg.odn.ne.jp
Niwa
Yasumasa
Y
Ando
Nobuhiro
N
Otsuka
Yasuro
Y
Ohmiya
Naoki
N
Hirooka
Yoshiki
Y
Itoh
Akihiro
A
Furuta
Shimako
S
Goto
Hidemi
H
D000368:Aged; D001549:Benzamides; D001707:Biopsy, Needle; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D010166:Palliative Care; D010879:Piperazines / Q000008:administration & dosage*; D011743:Pyrimidines / Q000008:administration & dosage*; D018570:Risk Assessment; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate