[Mesenchymal dysplasia of heart valves, cystic medianecrosis of the aorta and herpetic infection].
Histologic and immunohistochemical studies (use of antibodies for viruses of herpes simplex type 1 and 2, desmin, vimentin, SMA as well as polymerase chain reaction to DNA of viruses of herpes simplex) were made on the material of the valves taken from 1326 patients with valvular heart disease, the ascending aorta of 30 patients with aneurysm, valves of 35 deceased patients without cardiovascular pathology. As a result, expression of viruses of herpes simplex type 1 and/or 2 was found in all cases with mesenchymal dysplasia and cystic medianecrosis in endotheliocytes, fibroblasts, smooth muscle cells of valves and aorta. This indicates the role of these viruses in the pathogenesis of these diseases and their common etiology.
Mitrofanova
L B
LB
Karev
V E
VE
Shliakhto
E V
EV
Koval'skiĭ
G B
GB
D000199:Actins / Q000032:analysis; D001011:Aorta / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D001014:Aortic Aneurysm / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D003893:Desmin / Q000032:analysis; D004727:Endothelium / Q000473:pathology / Q000821:virology; D005347:Fibroblasts / Q000473:pathology / Q000821:virology; D006349:Heart Valve Diseases / Q000473:pathology / Q000821:virology*; D006351:Heart Valves / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D006566:Herpesviridae Infections / Q000150:complications*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D018258:Herpesvirus 2, Human / Q000302:isolation & purification; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000473:pathology / Q000821:virology; D009336:Necrosis / Q000473:pathology / Q000821:virology; D014746:Vimentin / Q000032:analysis
D000199:Actins; D004279:DNA, Viral; D003893:Desmin; D014746:Vimentin