Oncolytic potential of rodent parvoviruses for cancer therapy in humans: a brief review.
Summary Rodent parvoviruses are promising candidates for oncolytic virotherapy of cancer in humans because of their oncotropism (preferential killing of transformed cells) in the absence of pathogenicity. Here, we give an overview concerning the possible application of parvovirus H-1 for cancer therapy, with specific emphasis on malignant brain tumours in humans.
Geletneky
K
K
Department of Neurosurgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
Herrero Y Calle
M
M
Rommelaere
J
J
Schlehofer
J R
JR
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D050130:Oncolytic Virotherapy; D010322:Parvoviridae Infections / Q000662:veterinary / Q000821:virology; D017992:Parvovirus; D051381:Rats; D012376:Rodent Diseases / Q000821:virology
D000970:Antineoplastic Agents