Synthesis and anti-inflammatory activity of resveratrol analogs.
Seventeen novel resveratrol derivatives were synthesized. Their anti-inflammatory activities were tested on xylene-induced mouse ear edema. The pharmacological results showed that some compounds have potent anti-inflammatory activities.
Chen
Guoliang
G
Pharmaceutical Engineering Department, Shenyang Pharmaceutical University, PR China. guoliang222@yahoo.com.cn
Shan
Wei
W
Wu
Yingliang
Y
Ren
Lixiang
L
Dong
Jinhua
J
Ji
Zhizhong
Z
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D007202:Indicators and Reagents; D008352:Mannich Bases; D051379:Mice; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D000077185:Resveratrol; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001555:Benzene Derivatives; D007202:Indicators and Reagents; D008352:Mannich Bases; D011725:Pyridines; D013267:Stilbenes; D000077185:Resveratrol