[Study on the hypoglycemic activity of different extracts of wild Psidium guajava leaves in Panzhihua Area].
OBJECTIVE
To illuminate the role of water-soluble, 650 ml/L edible alcohol and 950 ml/L edible alcohol-soluble extracts of wild Psidium guajava leaves in Panzhihua Area in decreasing blood glucose.


METHODS
High-level blood glucose models were made by use of male Kunming mice given intraperitoneal injection of glucose, subcutaneous injection of adrenaline and intraperitoneal injection of streptozotocin (STZ), respectively. Blood glucose concentration was measured after oral administration (gastrogavage) of the soluble extracts of Psidium guajava leaves, respectively. Body weight and organ morphology were observed, and organ index was obtained. The All available indexes were statistically analyzed in comparing the study groups and control group.


RESULTS
three extracts resisted the rise of blood glucose level induced by exogenous glucose and adrenaline to various degrees. The extracts of water, 650 ml/L alcohol and 950 ml/L alcohol significantly decreased the blood glucose level in STZ-induced diabetic mice by 36.3%, 33.5% and 31.3% respectively. Furthermore, among three extracts, water-soluble extract showed little influence on the growth of mice.


CONCLUSIONS
The water-soluble, 650 ml/L edible alcohol and 950 ml/L edible alcohol-soluble extracts of wild Psidium guajava leaves in Panzhihua area may have different hypoglycemic potential.
Wang
Bo
B
Department of Medical Technology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Liu
Heng-Chuan
HC
Ju
Chang-Yan
CY
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D031647:Psidium / Q000737:chemistry*; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D010936:Plant Extracts