title: Overweight and metabolic and hormonal parameter disruption are induced in adult male mice by manipulations during lactation period.
abstract: Neonatal manipulations (10 min of maternal separation plus s.c. sham injection, daily for the first 21 d of life) determine overweight in male adult mice. In this work, we investigated the mechanisms underlying mild obesity and the alteration of caloric balance. Neonatally manipulated mice become overweight after onset of maturity, showing increased fat tissue and hypertrophic epididymal adipocytes. Increase in body weight occurs in the presence of a small increase in daily food intake (significant only in the adult period) and the absence of a decrease in spontaneous locomotor activity, while the calculated caloric efficiency is higher in manipulated mice, especially in adulthood. Fasting adult animals show hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia, and hyperleptinemia. Soon after weaning and in the adulthood, plasma corticosterone and adrenocorticotropin (ACTH) are also significantly increased. Thus, neonatal manipulations in nongenetically susceptible male mice program mild obesity, with metabolic and hormonal alterations that are similar to those found in experimental models of diabetes mellitus, suggesting that this metabolic derangement may have at least part of its roots early on in life and, more interestingly, that psychological and nociceptive stimuli induce these features.
authors.affiliation: Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Roma, Italy. alberto.loizzo@iss.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Loizzo
authors.forename: Stefano
authors.initials: S
authors.lastname: Loizzo
authors.forename: Gabriella
authors.initials: G
authors.lastname: Galietta
authors.forename: Stefania
authors.initials: S
authors.lastname: Caiola
authors.forename: Santi
authors.initials: S
authors.lastname: Spampinato
authors.forename: Gabriele
authors.initials: G
authors.lastname: Campana
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Seghieri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ghirlanda
authors.forename: Flavia
authors.initials: F
authors.lastname: Franconi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D004326:Drinking; D004435:Eating; D002149:Energy Intake; D004822:Epididymis / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D007774:Lactation; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D009043:Motor Activity; D050177:Overweight
chemical_list: D001786:Blood Glucose; D006728:Hormones; D008055:Lipids