title: How proteomics reveals potential biomarkers in brain diseases.
abstract: The brain is complex, and so are the proteomics studies of brain tissue and its diseases, including Alzheimer's Disease, Parkinson's Disease and schizophrenia. In this review, general considerations and strategies of proteomics technologies, the advantages and challenges as well as the special needs for brain tissue are described and summarized. In addition, the results of the first studies are presented including a quality evaluation of the candidate proteins for these diseases. A paragraph is dedicated to the efforts of standardization in this field.
authors.affiliation: Ruhr-Universitaet Bochum, Medizinisches Proteom-Center, ZKF E.141, Universitaetsstrasse 150, D-44801 Bochum, Germany. oliver.schmidt@rub.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Schmidt
authors.forename: Thomas
authors.initials: T
authors.lastname: Schulenborg
authors.forename: Helmut E
authors.initials: HE
authors.lastname: Meyer
authors.forename: Katrin
authors.initials: K
authors.lastname: Marcus
authors.forename: Michael
authors.initials: M
authors.lastname: Hamacher
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001927:Brain Diseases / Q000378:metabolism*; D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D013058:Mass Spectrometry; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers