Nascent peptide in the "birth canal" of the ribosome.
All proteins assembled by the ribosome must pass through the nascent-peptide exit tunnel. Some nascent peptides can specifically interact with the tunnel and affect the functions of the ribosome. The molecular mechanisms of such interactions and of the ribosome response are currently unknown. However, a recent study has revealed elements of the tunnel that might be involved in sensing the nascent-peptide sequence.
Mankin
Alexander S
AS
Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 S. Ashland Avenue, Chicago, IL 60607, USA. shura@uic.edu
D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D021381:Protein Transport; D012269:Ribosomal Proteins / Q000378:metabolism / Q000502:physiology*; D012270:Ribosomes / Q000502:physiology* / Q000648:ultrastructure; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism
D029968:Escherichia coli Proteins; D012269:Ribosomal Proteins; C497347:SecM protein, E coli; D014157:Transcription Factors