Impact of pathogen burden on in-stent restenosis in patients after coronary stent implantation.
BACKGROUND
Although some certain infectious pathogens could be detected in the patients with coronary artery disease, the roles of these infectious factors in the development of coronary artery diseases remain largely unknown. Since the number of infectious pathogens has been argued to be relative to the coronary artery diseases, we therefore examined whether there is a link between the number of infections and the incidence of in-stent restenosis after stent implantation.


METHODS
One hundred and eighty-one patients were enrolled in this study. Infectious pathogens including serum anti-Chlymydia pneumoniae, cytomegalovirus, Helico pylori, human herpes simplex virus-1, human herpes simplex virus-2 antibodies and hepatitis B virus antigen were measured in all patients before coronary stent implantation. Coronary angiography was performed before, immediately after and 6 months after stent implantation.


RESULTS
Restenosis rate 6 months post stent implantation was similar in patients with low pathogen burden (< 3 pathogens, 33.3%) to those with high pathogen burden (> or = 3 pathogens, 29.1%).


CONCLUSIONS
Previous infections with Chlymydia pneumoniae, cytomegalovirus, Helico pylori, human herpes simplex virus-1, human herpes simplex virus-2 and hepatitis B virus do not contribute to the incidence of restenosis after stent implantation.
Niu
Yu-hong
YH
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Ge
Jun-bo
JB
Xu
Cong-feng
CF
Shi
Jian-hui
JH
Jin
Xue-juan
XJ
Qian
Ju-ying
JY
Zou
Yun-zeng
YZ
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015607:Stents / Q000009:adverse effects*