Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings.
This article reports on a novel two-step strategy for the coating of cardiovascular stents by strongly adhering biocompatible and biodegradable aliphatic polyesters. First, a precoating of poly(ethylacrylate) (PEA) was electrografted onto the metallic substrate by cathodic reduction of the parent monomer in dimethylformamide (DMF). The electrodeposition of PEA, in a good solvent of it, was confirmed by both Infra-red and Raman spectroscopies. The pendant ester groups of PEA were then chemically reduced into aluminum alkoxides, able to initiate the ring-opening polymerization (ROP) of either D,L-lactide (LA) or epsilon-caprolactone (CL). Growth of biodegradable PLA or PCL coatings from the adhering precoating was confirmed by both Infra-red and Raman spectroscopies, and directly observed by scanning electron microscopy (SEM). This type of coating can act as an anchoring layer for the subsequent casting of drug-loaded polyester films allowing the controlled release of antiproliferative agents for the treatment of in-stent restenosis.
Jérôme
Christine
C
Center for Education and Research on Macromolecules (CERM), Institute of Chemistry, B6, University of Liège, Sart-Tilman, B6, 4000 Liège, Belgium. c.jerome@ulg.ac.be
Aqil
Abdelhafid
A
Voccia
Samuël
S
Labaye
David-Emmanuel
DE
Maquet
Véronique
V
Gautier
Sandrine
S
Bertrand
Olivier F
OF
Jérôme
Robert
R
D001672:Biocompatible Materials / Q000737:chemistry*; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004595:Electroplating / Q000379:methods; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D015607:Stents; D013499:Surface Properties
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011091:Polyesters