Recent insights into the mechanisms of Chlamydia entry.
Chlamydia are widespread bacteria that grow in human and animal cells. They enter their host cell, establish an intracellular environment favourable for their multiplication and finally exit the host cell. A combination of host cell factors and of bacterial proteins contribute to pathogen entry. Recent advances have shed new light on the entry mechanism, following attachment. Here we review recent data concerning endocytosis, host cell signalling, proteins secreted by the bacteria, the actin cytoskeleton in entry and the involvement of small GTPases.
Dautry-Varsat
Alice
A
Unité de Biologie des Interactions Cellulaires, Institut Pasteur, URA CNRS 2582, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. adautry@pasteur.fr
Subtil
Agathe
A
Hackstadt
Ted
T
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D000818:Animals; D002689:Chlamydia / Q000472:pathogenicity / Q000502:physiology*; D002690:Chlamydia Infections / Q000382:microbiology*; D003599:Cytoskeleton / Q000378:metabolism; D004705:Endocytosis; D004847:Epithelial Cells / Q000382:microbiology / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism; D015398:Signal Transduction; D037521:Virulence Factors
D000089982:ADP-Ribosylation Factor 6; D000199:Actins; D037521:Virulence Factors; D020558:GTP Phosphohydrolases; D020727:ADP-Ribosylation Factors