A novel index to estimate the corpus callosum morphometry in adults: callosal/supratentorial-supracallosal area ratio.
OBJECTIVE
To prospectively investigate the feasibility of a new index (callosal/supratentorial-supracallosal area ratio) in morphometric analysis of the corpus callosum in adults.


METHODS
The callosal and supratentorial-supracallosal areas of 50 healthy volunteers were measured on T1 weighted midsagittal magnetic resonance images. Mean value and variation coefficient for the index was calculated. In a limited subset of subjects (n=25), an interobserver agreement study was conducted to estimate the reproducibility of the index.


RESULTS
There was a statistically significant difference between the area for corpus callosum and supratentorial-supracallosal regions in males and females, although the calculated ratio (index) had no sex-difference. When compared to the literature, the variation coefficient was relatively lower (12.0%), with good interobserver agreement (Pearson correlation analysis, r=0.83).


CONCLUSIONS
Callosal/supratentorial-supracallosal area ratio might serve as a reliable index in morphometric analysis of the corpus callosum in adults.
Erdoğan
Nuri
N
Department of Radiology, Erciyes University School of Medicine, Kayseri, Turkey, Turkey. nerdogan@erciyes.edu.tr
Ulger
Harun
H
Tuna
Ibrahim
I
Okur
Aylin
A
D000293:Adolescent; D000328:Adult; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results