title: Electrical inhibition of preterm birth: inhibition of uterine contractility in the rabbit and pup births in the rat.
abstract: OBJECTIVE
  The purpose of this study was to inhibit uterine contractility during parturition with an electrical current, which is called electrical inhibition, in the rabbit and the rat.
  
  
  METHODS
  We studied the electrical inhibition of in vitro spontaneously contracting preterm or term gestational rat myometrium tissue and in vivo spontaneously contracting uterus either directly in the rabbit and rat or transvaginally in the rat. Values for myometrial tension, intrauterine pressure, pup birth intervals, and electromyographic activity before and after electrical inhibition were compared.
  
  
  RESULTS
  Electrical inhibition decreased rat in vitro myometrial tension by 50%, decreased in vivo rabbit intrauterine pressure by 48%, decreased in vivo rat intrauterine pressure by 80%, and increased birth intervals (latency) by factors of 50 (direct electrical inhibition) and 20 (transvaginal electrical inhibition). All electromyographic activity parameters were reduced significantly.
  
  
  CONCLUSIONS
  Electrical inhibition of the uterus is possible. Electrical inhibition is rapid and localized; the duration can be prolonged, and the reversibility is spontaneous. Electrical inhibition may be a new method of tocolysis in the human.
authors.affiliation: Neonatology Department, New York Downtown Hospital, New York, NY 10038-2649, USA. Jeffrey.Karsdon@downtownhospital.org
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Karsdon
authors.forename: Robert E
authors.initials: RE
authors.lastname: Garfield
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Shi
authors.forename: William
authors.initials: W
authors.lastname: Maner
authors.forename: George
authors.initials: G
authors.lastname: Saade
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D019540:Area Under Curve; D004599:Electric Stimulation Therapy; D004576:Electromyography; D005260:Female; D066298:In Vitro Techniques; D011247:Pregnancy; D047928:Premature Birth / Q000503:physiopathology* / Q000517:prevention & control; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D014590:Uterine Contraction / Q000502:physiology*; D014599:Uterus / Q000503:physiopathology