Explanation for the survival benefit of primary angioplasty over thrombolytic therapy in patients with ST-elevation acute myocardial infarction.
Our study evaluated the interaction across mortality risk, time delay related to percutaneous coronary intervention (PCI), and survival benefit of PCI over thrombolytic therapy (risk-time benefit analysis). Mortality risk and angioplasty-related time delay were independently correlated to 30-day survival benefit of primary angioplasty over lytic therapy. A PCI-related delay>60 minutes could be justified for high-risk patients.
Tarantini
Giuseppe
G
The Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova Medical School, Padua, Italy. giuseppe.tarantini.l@unipd.it
Razzolini
Renato
R
Ramondo
Angelo
A
Napodano
Massimo
M
Bilato
Claudio
C
Iliceto
Sabino
S
D015906:Angioplasty, Balloon, Coronary; D004562:Electrocardiography; D006801:Humans; D009203:Myocardial Infarction / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D015912:Thrombolytic Therapy; D013997:Time Factors