[Change rate in bone cells of mice].
OBJECTIVE
To study the anti-mutation action of acupuncture and moxibustion.


METHODS
Mice were randomly divided into 6 groups, group 1 (normal control group), group 2 (positive control group), group 3 (prevention group I), group 4 (prevention group II ), group 5 (treatment group I) and group 6 (treatment group II). The mice in the group 2-6 were treated by cyclophosphamide (ip, 50 mg/kg body weight), and in the 3'-6 groups were given acupuncture at "Zusanli" (ST 36) and moxibustion at "Guanyuan" (CV 4). At the end of experiment, all the mice were decapitated and chromosome aberration rate and sister chromatid exchange rate of bone marrow cells were investigated.


RESULTS
The chromosome aberration rate and the sister chromatid exchange rate of bone marrow cells in the positive control group increased significantly as compared with the normal control group, while they decreased significantly in the group 3, 4, 5, 6 as compared with the positive control group (P < 0.01).


CONCLUSIONS
Acupuncture and moxibustion have anti-mutation action, inhibiting the increase of chromosome aberrations and sister chromatid exchange of bone marrow cells in mice induced by cyclophosphamide.
Zhang
Shi-min
SM
Zhangjiakou Medical College, Hebei 075029, China. ztt4321@163.com
Wei
Hui-ping
HP
Yang
Chun-mei
CM
Tian
Cui-shi
CS
Li
Ji-hong
JH
D015670:Acupuncture Therapy; D000818:Animals; D003520:Cyclophosphamide; D051379:Mice; D009071:Moxibustion
D003520:Cyclophosphamide