title: Antibacterial activity directed isolation of compounds from Onosma hispidum.
abstract: The chemical investigation of the ethanolic extract of the root bark of Onosma hispidum following antibacterial activity directed isolation led to the isolation of 4-hydroxy-3-methoxy cinnamic acid (ferulic acid) and 4-hydroxy-3-methoxy benzoic acid (vanillic acid) which have been reported for the first time in this species. In addition to these compounds, the crude ethanolic extract and methanol fraction exhibited substantial bioactivity against species of corynebacteria, enterococci, staphylococci and streptococci. Ferulic acid was found more bioactive (being relatively more hydrophobic) compared to vanillic acid.
authors.affiliation: Department of Food Science & Technology, University of Karachi, Karachi-75270, Pakistan. sn_66pk@yahoo.com
authors.forename: Shahina
authors.initials: S
authors.lastname: Naz
authors.forename: Samia
authors.initials: S
authors.lastname: Ahmad
authors.forename: Sheikh
authors.initials: S
authors.lastname: Ajaz Rasool
authors.forename: Syed
authors.initials: S
authors.lastname: Asad Sayeed
authors.forename: Rahmanullah
authors.initials: R
authors.lastname: Siddiqi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028082:Boraginaceae / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D014641:Vanillic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003373:Coumaric Acids; C004999:ferulic acid; D014641:Vanillic Acid