Hormone replacement therapy and longitudinal cognitive performance in postmenopausal women.
OBJECTIVE
The authors examined the impact of hormone replacement therapy (HRT) on longitudinal cognitive performance (controlling for mood state) in 69 community-dwelling, postmenopausal women.


METHODS
The authors conducted a 5-year follow-up of cognitive performance in 37 postmenopausal HRT users and 32 non-users. The groups did not differ with respect to age, years of education, or inter-test interval.


RESULTS
No main effect of HRT was observed on any of the cognitive measures, and depressive symptomatology did not affect the relationship between HRT and cognition.


CONCLUSIONS
Overall, our findings do not suggest that HRT affects longitudinal cognitive performance in postmenopausal, community-dwelling older women.
O'Hara
Ruth
R
Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550, USA. roh@leland.stanford.edu
Schröder
Carmen M
CM
Bloss
Cinnamon
C
Bailey
Amber M
AM
Alyeshmerni
Aviva M
AM
Mumenthaler
Martin S
MS
Friedman
Leah F
LF
Yesavage
Jerome A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000187:drug effects*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D017698:Postmenopause / Q000502:physiology*; D011795:Surveys and Questionnaires