Acute morphine exposure potentiates the development of HSV-1-induced encephalitis.
A devastating consequence of HSV-1 infection is development of HSV-1-induced encephalitis (HSVE). While only a minority of individuals infected with HSV-1 experiences HSVE, clearly defined variables that consistently predict development of the disease remain to be elucidated. The current study examined the effects of a single dose of morphine prior to infection with HSV-1 on the development of HSVE in BALB/cByJ mice. Acute morphine exposure was observed to potentiate the development of HSVE in HSV-1 infected mice. The present data implicate a potential role for the blood-brain barrier in the development of HSVE in morphine-treated mice.
Lioy
Daniel T
DT
Department of Microbiology and Immunology, 575 Elmwood Ave., University of Rochester, Rochester, NY 14621, United States.
Sheridan
Patricia A
PA
Hurley
Sean D
SD
Walton
James R
JR
Martin
Amy M
AM
Olschowka
John A
JA
Moynihan
Jan A
JA
D000818:Animals; D001259:Ataxia / Q000209:etiology / Q000821:virology; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000503:physiopathology / Q000821:virology; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004660:Encephalitis / Q000209:etiology* / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000472:pathogenicity / Q000502:physiology*; D007074:Immunoglobulin G / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D010243:Paralysis / Q000209:etiology / Q000821:virology; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012720:Severity of Illness Index; D013997:Time Factors
D007074:Immunoglobulin G; D009294:Narcotics; D012333:RNA, Messenger; D008353:Mannitol; D009020:Morphine