[Ocular toxicity caused by tamoxifen: case report].
To report tamoxifen ocular toxicity. The best visual acuity was measured in both eyes with Snellen chart, slit-lamp examination of anterior segment, refraction, dilated fundus examination, fluorescein angiography and retinography in a 63-year-old patient, female, white, using tamoxifen 20 mg/day for 4 years, with 20/70 and 20/40 corrected visual acuity. The anterior segment examination showed corneal linear subepithelial opacity inferior to the visual axis and nuclear and posterior cortical cataract (1+/4) in both eyes. Fundus examination showed alteration of macular color in both eyes. Fluorescein angiography presented hyperfluorescence in the macular area at an early phase (window defect). Report of keratopathy and maculopathy caused by tamoxifen.
Inada
Eliane Terumi
ET
Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP. T_inada@ig.com.br
Watanabe
Karina Paula
KP
Tanaka
Sérgio Gustavo
SG
Sakakisbara
Luís Antônio
LA
D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D002386:Cataract / Q000139:chemically induced; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000139:chemically induced*; D008875:Middle Aged; D013629:Tamoxifen / Q000009:adverse effects*; D014792:Visual Acuity / Q000187:drug effects*
D018931:Antineoplastic Agents, Hormonal; D004965:Estrogen Antagonists; D013629:Tamoxifen