Relationship between growth and plasma concentrations of ghrelin and growth hormone in juvenile beagle dogs.
Although the release of growth hormone (GH) is known to be regulated mainly by GH-releasing hormone (GHRH) and somatostatin (SRIF) secreted from the hypothalamus, ghrelin also may be involved in GH release during juvenile period. We have examined plasma concentrations of acylated ghrelin, desacyl ghrelin, and GH in juvenile beagle dogs. Plasma acylated and desacyl ghrelin levels changed through aging; however, there was no closely correlation between ghrelin, body weight and circulating GH levels during juvenile period. The increase in body weight was essentially linear until 8 months of age, whereas plasma GH concentrations exhibited bimodal peaks for the meanwhile. The results suggest that ghrelin may not play internal cueing in GH secretion in juvenile beagle dogs.
Yokoyama
Masayuki
M
Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Japan.
Murakami
Noboru
N
Naganobu
Kiyokazu
K
Hosoda
Hiroshi
H
Kangawa
Kenji
K
Nakahara
Keiko
K
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D004285:Dogs / Q000097:blood* / Q000254:growth & development*; D054439:Ghrelin; D013006:Growth Hormone / Q000097:blood*; D036361:Peptide Hormones / Q000097:blood*
D054439:Ghrelin; D036361:Peptide Hormones; D013006:Growth Hormone