[Effects of ethanol ingestion on glucose tolerance in people with different genotypes of ALDH2].
Effects of alcohol drinking on glucose tolerance were investigated in male healthy subjects (20-36 years old) with different phenotypes of aldehyde dehydrogenase 2 (ALDH2). Oral glucose tolerance test was performed in each subject twice with and without simultaneous oral ingestion of ethanol. Simultaneous oral ingestion of ethanol (10 g) significantly enhanced the early increase in plasma insulin concentration at 30 min after ingestion of glucose (100 g) in subjects with normal ALDH2 phenotype, while the increase in early insulin response due to alcohol was slight and not significant in those with atypical ALDH2. On the other hand, the early increase in plasma glucose concentration at 30 min after glucose inges-tion was not affected by simultaneous ethanol drinking in both groups of subjects with normal and atypical ALDH2 phenotypes. Thus, drinking alcohol together with a simple sugar causes enhancement of early insulin response, which is more prominent in people with normal ALDH2 phenotype than in those with atypical ALDH2 phenotype.
Negoro
Munetake
M
Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan.
Marumo
Mikio
M
Takahashi
Yuji
Y
Wakabayashi
Ichiro
I
D000328:Adult; D000428:Alcohol Drinking; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D010641:Phenotype
C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial