title: Effects of topical sesame oil on oxidative stress in rats.
abstract: OBJECTIVE
  To assess the effects of topical sesame oil on systemic oxidative stress in rats.
  
  
  METHODS
  Oxidative stress was induced with lipopolysaccharide and assessed by determining serum lipid peroxidation, superoxide anion, and hydroxyl radical levels. The levels of 3 circulating antioxidants--superoxide dismutase, catalase, and glutathione--also were determined.
  
  
  RESULTS
  Topical sesame oil significantly reduced lipid peroxidation, superoxide anion, and hydroxyl radical levels after lipopolysaccharide administration. However, sesame oil did not affect the 3 circulating antioxidants. Further, sesame oil decreased the activity of xanthine oxidase and nitric oxide production in lipopolysaccharide-treated rats.
  
  
  CONCLUSIONS
  Sesame oil given topically might attenuate oxidative stress by inhibiting the production of xanthine oxidase and nitric oxide in rats.
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan.
authors.forename: James Po-Jung
authors.initials: JP
authors.lastname: Chiang
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Jui-Chen
authors.initials: JC
authors.lastname: Tsai
authors.forename: Hamm-Ming
authors.initials: HM
authors.lastname: Sheu
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000818:Animals; D002374:Catalase / Q000032:analysis / Q000187:drug effects; D004195:Disease Models, Animal; D005978:Glutathione / Q000032:analysis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008070:Lipopolysaccharides; D008163:Luminescent Measurements; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011336:Probability; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000032:analysis* / Q000378:metabolism; D012680:Sensitivity and Specificity; D012715:Sesame Oil / Q000008:administration & dosage / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000032:analysis / Q000187:drug effects
chemical_list: D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species; D012715:Sesame Oil; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione