title: Montelukast improves pulmonary function measured by impulse oscillometry in children with asthma (Mio study).
abstract: BACKGROUND
  Systemic drugs-like oral montelukast can reach lower airways, whose inflammation plays a crucial role in the evolution of asthma, while inhaled drugs hardly reach them. The impulse oscillometry (IOS) technique is useful to evaluate both central and peripheral airways function.
  
  
  OBJECTIVE
  To measure the effect of oral montelukast on airways resistance evaluated by oscillometry in children with asthma.
  
  
  METHODS
  In an open study, respiratory function in 23 children with mild asthma and a positive bronchodilator response was assessed by spirometry and oscillometry. They took oral montelukast during 4 weeks and were again evaluated. As a control group, 23 similar patients with no preventive treatment underwent the same study.
  
  
  RESULTS
  Children on oral montelukast showed improvements (measured in kPa s L(-1)) in all oscillometry parameters: mean 0.20 (22.4%) in total respiratory impedance Zrs5, 0.18 (21.8%) in total airway resistance Rrs5, 0.09 (17.8%) in central airway resistance Rrs20, and 0.09 (28.8%) in distal capacitive reactance Xrs5; the frequency of resonance Fres improved 2.3 Hz (8.7%) (P<0.05 in all cases). No changes were found in the control group. Expiratory flows showed no changes except for a small (0.23 L s(-1), 7.4%) but significant worsening of FEF25-75 in the control group.
  
  
  CONCLUSIONS
  Montelukast improves central and especially peripheral airways function in the first month of treatment, as evaluated by IOS, a technique based on tidal breathing analysis which is more sensitive than conventional forced spirometry.
authors.affiliation: Pediatric Allergy Unit, Children's Hospital, Av. Campanar 21, Valencia 46009, Spain. nieto_ant@gva.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Nieto
authors.forename: Rafael
authors.initials: R
authors.lastname: Pamies
authors.forename: Fernando
authors.initials: F
authors.lastname: Oliver
authors.forename: Alejandra
authors.initials: A
authors.lastname: Medina
authors.forename: Luis
authors.initials: L
authors.lastname: Caballero
authors.forename: Angel
authors.initials: A
authors.lastname: Mazon
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D000284:Administration, Oral; D000293:Adolescent; D000403:Airway Resistance / Q000187:drug effects; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D003521:Cyclopropanes; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D008297:Male; D009991:Oscillometry / Q000379:methods; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D011804:Quinolines / Q000627:therapeutic use*; D013440:Sulfides; D016896:Treatment Outcome
chemical_list: D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast