title: Platelet activation is associated with hypoadiponectinemia and carotid atherosclerosis.
abstract: Adiponectin, an adipokine secreted specifically from adipose tissue, has plurifunctions including antidiabetic, antiatherosclerotic, and antiinflammatory functions. Recently, platelet activation and the subsequent local inflammation have been implicated in progression of atherosclerosis. The aim of the study is to examine the interrelation among plasma adiponectin levels, platelet activation status and quantitatively determined carotid atherosclerosis. Subjects (n = 277) including 136 type 2 diabetic, 138 hypertensive, and 203 hypercholesterolemic patients participated in the study. Platelet activation was determined as percentage of polymorphonuclear cells (PMNs) or monocytes aggregated with platelets analyzed by CD41-positivity determined by whole-blood flow cytometry. PMN-platelet aggregates were significantly and positively associated with carotid atherosclerosis (intimal-medial thickness, IMT) with the interaction stronger than that of monocyte-platelet aggregates. Stepwise regression analyses revealed that PMN-platelet aggregates were the third strongest determinant of carotid IMT, with age and HbA1c stronger independent determinants. Simple and stepwise regression analyses of the factors associated with PMN-platelet aggregates revealed that HbA1c (r = 0.423), serum adiponectin levels (r = -0.289) and age (r = -0.184) were the three independent determinants. Thus, our data unveil novel link between hypoadiponectinemia and platelet activation.
authors.affiliation: Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Takuhito
authors.initials: T
authors.lastname: Shoji
authors.forename: Hidenori
authors.initials: H
authors.lastname: Koyama
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Takaaki
authors.initials: T
authors.lastname: Maeno
authors.forename: Hisayo
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Kayo
authors.initials: K
authors.lastname: Shinohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Emoto
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shoji
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shioi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D001792:Blood Platelets / Q000502:physiology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002340:Carotid Artery Diseases / Q000473:pathology / Q000503:physiopathology*; D002449:Cell Aggregation; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D052242:Adiponectin