title: Testicular tumor in Down syndrome.
abstract: A 33-year-old male patient with Down syndrome, who stayed in a welfare institution, visited our hospital due to left testicular enlargement. He was diagnosed as having a left testicular tumor and underwent radical inguinal orchiectomy. Preoperatively, serum level of beta-human chorionic gonadotrophin (beta-HCG) increased to 0.9 ng/mL (normal range <0.2 ng/mL). For the last 2 years after orchiectomy, the serum level of beta-HCG remained normal. Histopathological examination of specimen revealed a typical seminoma. It is currently thought that risk of developing leukemia in patients with Down syndrome is 20- to 30-fold higher than that in normal subjects. Furthermore, the incidence of testicular cancer as a complication other than leukemia is expected to increase because of the increasing postpubertal population with Down syndrome.
authors.affiliation: Department of Urology, Toho University Sakura Hospital, Sakura, Japan. charu_suzu@yahoo.co.jp
authors.forename: Kuri
authors.initials: K
authors.lastname: Suzuki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishimi
authors.forename: Tsuguo
authors.initials: T
authors.lastname: Yagishita
authors.forename: Masaharu
authors.initials: M
authors.lastname: Takanami
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hiruta
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009919:Orchiectomy; D018239:Seminoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013736:Testicular Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery