Investigation of noncovalent complexes between beta-cyclodextrin and polyamide acids containing N-methylpyrrole and N-methylimidazole by electrospray ionization mass spectrometry.
Electrospray ionization (ESI) mass spectrometry was utilized to investigate noncovalent complexes between beta-cyclodextrin (beta-CD) and five novel polyamide acids containing N-methylpyrrole and N-methylimidazole. The 1:1 binding mode was specified by examining the binding stoichiometry from ESI mass spectra. It found that polyamide acids with beta-CD have binding affinities in the order: ImImImbetaCOOH > ImPyImbetaCOOH > ImPyPybetaCOOH > PyPyPybetaCOOH > NO(2)PyPyPybetaCOOH. The method gives, simultaneously, the binding constants between beta-CD and polyamide acids based on a novel linear equation.
Li
Huihui
H
Department of Chemical Biology, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry, Peking University, Beijing, China.
Zhou
Jiang
J
Tang
Feili
F
Yuan
Gu
G
D000465:Algorithms; D007093:Imidazoles / Q000737:chemistry*; D016014:Linear Models; D009757:Nylons / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D047392:beta-Cyclodextrins / Q000737:chemistry*
D007093:Imidazoles; D009757:Nylons; D011758:Pyrroles; D047392:beta-Cyclodextrins; C031215:betadex; C096654:N-methylpyrrole; C018100:1-methylimidazole