Microtubule flux: what is it good for?
During mitosis in a eukaryotic cell, microtubule subunits continuously move towards spindle poles. A new study has revealed that inhibiting this microtubule flux in mammalian cells has no major effects on chromosome movements; it does, however, increase the probability of erroneous chromosome segregation.
Khodjakov
Alexey
A
Division of Molecular Medicine,Wadsworth Center, New York State Department of Health, Albany, New York 12201-0509, USA.
Kapoor
Tarun
T
D020090:Chromosome Segregation / Q000502:physiology*; D016547:Kinesins / Q000378:metabolism; D018386:Kinetochores / Q000502:physiology; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D008941:Spindle Apparatus / Q000502:physiology*; D014404:Tubulin / Q000378:metabolism
D014404:Tubulin; D016547:Kinesins