The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemia.
We analyzed the expression of deoxycytidine kinase (dCK), UMP/CMP-kinase (UMP/CMP-K), nucleotide diphosphokinase (NDPK-B) and 5'-nucleotidases cN-II, cN-III, cdN and mdN by quantitative polymerase chain reaction at diagnosis in leukemic blasts from 96 patients with acute myeloid leukemia (AML) treated with ara-C. Our results show that high mRNA levels of cN-II and low mRNA levels of cN-III are correlated with a worse clinical outcome and suggest that these enzymes may have a role in sensitivity to ara-C in AML patients.
Galmarini
Carlos María
CM
Cros
Emeline
E
Thomas
Xavier
X
Jordheim
Lars
L
Dumontet
Charles
C
D015720:5'-Nucleotidase / Q000096:biosynthesis / Q000235:genetics*; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000201:enzymology; D003561:Cytarabine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000201:enzymology*; D011379:Prognosis; D016016:Proportional Hazards Models; D011742:Pyrimidine Nucleotides / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis* / Q000097:blood; D012334:RNA, Neoplasm / Q000032:analysis* / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016019:Survival Analysis; D016896:Treatment Outcome
D000964:Antimetabolites, Antineoplastic; D006023:Glycoproteins; D009363:Neoplasm Proteins; D011742:Pyrimidine Nucleotides; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D003561:Cytarabine; D015720:5'-Nucleotidase; C508048:NT5C2 protein, human; C412794:NT5C3A protein, human