title: Aggravating factors in the development of ocular abnormalities in farmed Atlantic halibut (Hippoglossus hippoglossus).
abstract: Cystic lesions in the eyes of farmed halibut with a number of ocular sequelae have been reported previously with evidence that the condition can be associated with increased activity of choroidal carbonic anhydrase and elevated oxygen tension in the aqueous humour of affected fish. These changes may be compared to the 'bends' in human divers which are characterized by elevated circulating levels of nitrogen together with aggravating factors such as physical exercise. It is postulated that bubble formation and subsequent development of cysts in halibut require not only high aqueous humour oxygen tension but also the imposition of factors such as handling or intraspecific aggression which lead to bubble formation. A significantly higher incidence of lesions was noted in fish handled, weighed and measured every two weeks compared with a control group of unhandled fish, suggesting that physical activity associated with handled and possibly also intraspecific aggression is a factor in generation of ocular lesions in these fish.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK. DoctorDLWilliams@aol.com
authors.forename: D L
authors.initials: DL
authors.lastname: Williams
authors.forename: W M
authors.initials: WM
authors.lastname: Brancker
mesh_terms: D000818:Animals; D005128:Eye Diseases / Q000209:etiology / Q000662:veterinary*; D005393:Fish Diseases / Q000209:etiology*; D005398:Fisheries / Q000379:methods; D005432:Flounder; D011897:Random Allocation