Epstein-Barr virus-associated post-transplant lymphoproliferative disease with central nervous system involvement after unrelated allogeneic hematopoietic stem cell transplantation.
Post-transplant lymphoproliferative disorders (PTLD) represent an heterogeneous group of abnormal lymphoid proliferation related to Epstein-Barr virus (EBV) reactivation that arise early after allogeneic hematopoietic stem cell transplant (HSCT). PLTD with central nervous system (CNS) involvement has been reported in few cases. We describe the case of a 31-year-old-man who developed an EBV-related PTLD with CNS involvement 2 months after an allogeneic unrelated HSCT for acute myeloid leukemia in first complete remission who was successfully treated with rituximab, cidofovir and intrathecal infusion of methotrexate and methylprednisolone.
Nozzoli
C
C
Department of Hematology, BMT Unit, University of Florence, Italy. c.nozzoli@dac.unifi.it
Bartolozzi
B
B
Guidi
S
S
Orsi
A
A
Vannucchi
A M
AM
Leoni
F
F
Bosi
A
A
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002490:Central Nervous System / Q000473:pathology*; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D012074:Remission Induction; D014184:Transplantation, Homologous; D016896:Treatment Outcome