title: Evaluation of the antibody response to Anopheles salivary antigens as a potential marker of risk of malaria.
abstract: The evaluation of human immune responses to arthropod bites may be a useful marker of exposure to vector-borne diseases, with applications to malaria, the most serious parasitic infection in humans. The specific antibody (Ab) IgG response to saliva obtained from Anopheles gambiae mosquitoes was evaluated in young children from an area of seasonal malaria transmission in Senegal. Specific IgG was higher in children who developed clinical Plasmodium falciparum malaria within the 3 months that followed than in those who did not (P<0.05), and it increased significantly (P<0.0001) with the level of Anopheles exposure, as evaluated by conventional entomological methods. These results suggest that evaluation of antisalivary Ab responses could be a useful approach for identifying a marker for the risk of malaria transmission.
authors.affiliation: Institut de Recherche pour le Développement (IRD), UR24 "Epidémiologie et Prévention" Unit, Centre IRD de Hann, BP 1386, Dakar, Sénégal. franck.remoue@ird.sn
authors.forename: Franck
authors.initials: F
authors.lastname: Remoue
authors.forename: Badara
authors.initials: B
authors.lastname: Cisse
authors.forename: Fatou
authors.initials: F
authors.lastname: Ba
authors.forename: Cheikh
authors.initials: C
authors.lastname: Sokhna
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Herve
authors.forename: Denis
authors.initials: D
authors.lastname: Boulanger
authors.forename: François
authors.initials: F
authors.lastname: Simondon
mesh_terms: D000818:Animals; D000852:Anopheles / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology*; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology / Q000635:transmission; D012307:Risk Factors; D012463:Saliva / Q000276:immunology; D012621:Seasons; D012675:Senegal
chemical_list: D000953:Antigens, Protozoan; D015415:Biomarkers; D007074:Immunoglobulin G