title: Pulse transit time changes observed with different limb positions.
abstract: Pulse transit time (PTT) is a non-invasive measure of arterial compliance. It can be used to assess instantaneous blood pressure (BP) changes in continual cardiovascular measurement such as during overnight respiratory sleep studies. In these studies, periodic changes in limb position can occur randomly. However, little is known about their possible effects on PTT monitored on the various limbs. The objective of this study was to evaluate PTT differences on all four limbs during two positional changes (lowering and raising of a limb). Ten healthy adults (seven male) with a mean age of 27.0 years were recruited in this study. The results showed that the limb that underwent a positional change had significant (p < 0.05) local PTT differences when compared to its nominal baseline value, whereas PTT changes in the other remaining limbs were insignificant (p > 0.05). The mean PTT value measured from a vertically-raised limb increased by 42.7 ms, while it decreased by 28.1 ms with a half-lowered limb. The PTT differences observed during positional change can be contributed to by the complex interactions between hydrostatic pressure changes, autonomic and local autoregulation experienced in these limbs. Hence the findings herein suggest that PTT is able to reflect local circulatory responses despite changes in the position of other limbs. This can be useful in prolonged clinical observations where limb movements are expected.
authors.affiliation: School of Information Technology and Electrical Engineering, The University of Queensland, St Lucia Campus, Brisbane 4072, Australia. jong@ieee.org
authors.forename: Jong Yong A
authors.initials: JY
authors.lastname: Foo
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wilson
authors.forename: Gordon R
authors.initials: GR
authors.lastname: Williams
authors.forename: Margaret-Anne
authors.initials: MA
authors.lastname: Harris
authors.forename: David M
authors.initials: DM
authors.lastname: Cooper
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods; D005121:Extremities / Q000098:blood supply* / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D011187:Posture / Q000502:physiology*; D011673:Pulsatile Flow / Q000502:physiology*; D013997:Time Factors