Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929.
The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be 1 alpha-hydroxy-3alpha-(4'-oxoundec-(5' E)-enyl)-pyrrolizidine and 1beta-hydroxy-3 alpha-(4'-oxoundec-(5 'E)-enyl)-pyrrolizidine, respectively, by comparison with spectral data of synthetic compounds.
Shibuya
Masaaki
M
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. shibuyam@mol.f.u-tokyo.ac.jp
Snider
Barry B
BB
Sakano
Yuichi
Y
Tomoda
Hiroshi
H
Omura
Satoshi
S
Ebizuka
Yutaka
Y
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry* / Q000145:classification; D006801:Humans; D019751:Intramolecular Transferases / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; C494514:epohelmin A; C494515:epohelmin B; D019751:Intramolecular Transferases; C021924:lanosterol synthase