title: Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats.
abstract: The present study attempted to evaluate the efficacy of enriched housing conditions in promoting behavioral recovery following subicular lesion. Rats with bilateral ibotenic acid lesions of ventral subiculum were exposed to either enriched housing conditions or standard housing for 6 h daily for 10 days. The performance of the lesioned rats reared in standard housing conditions was severely impaired in both 8-arm radial maze and water maze tasks. Lesioned rats exposed to enriched housing showed behavioral recovery in the 8-arm radial maze but not in the water maze. Our study suggests the possibility that recovery may be based on the functional demand of spatial tasks and may require more appropriate environmental stimulation.
authors.affiliation: Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), P.O. Box No.2900, Hosur Road, Bangalore-560 029, India.
authors.forename: B
authors.initials: B
authors.lastname: Bindu
authors.forename: J
authors.initials: J
authors.lastname: Rekha
authors.forename: Bindu M
authors.initials: BM
authors.lastname: Kutty
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004779:Environment Design; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D006799:Housing, Animal; D007051:Ibotenic Acid / Q000633:toxicity; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000502:physiology
chemical_list: D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid