[Effects of baisong tablets on the behavior and levels of norepinephrine and dopamine in the brain of stress rats].
OBJECTIVE
To explore the effects of baisong tablets on the behavior and contents of norepinephrine and dopamine in the brain of stress rats.


METHODS
Forty adult Sprague-Dawley male rats were randomly divided into 4 groups: the control group, the depression model group, the baisong tablet group and the fluoxetine group. The depression model was replicated by chronic unpredictable mild stress and single house in 21 days. Ten rats as a group were treated with baisong tablets or fluoxetine hydrochloride. Changes of behaviors were observed by open-field test and the volume of sugar-solution the rat drank in 24 hours. The weight increase was also observed. The levels of norepinephrine and dopamine in the brain in each group were detected with high-pergomance liquid chromatography.


RESULTS
Compared with the model group, baisong tablets could improve the depressive behaviors significantly, and increase the levels of norepinephrine and dopamine in the rat brain.


CONCLUSIONS
Baisong tablets can improve the depressive behaviors and increase the levels of 5-hydroxytryptaimne and dopamine in the brain of stress rats.
Song
Wei-Xi
WX
Institute of Combination of Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha, China. songweixi911@sina.com
Hu
Sui-Yu
SY
Huang
Chuan-Yuan
CY
Chen
Chang-Hua
CH
Wang
Zhe
Z
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013607:Tablets
D004365:Drugs, Chinese Herbal; D013607:Tablets; D004298:Dopamine; D009638:Norepinephrine