title: Partial seizures triggering infantile spasms in the presence of a basal ganglia glioma.
abstract: Infantile spasms associated with brain tumors have been reported. A focal cortical lesion can induce infantile spasms by triggering the brainstem and basal ganglia in this vulnerable age group. We report the case of a female infant with a low-grade glioma in the right basal ganglia, spreading to the cortical area. She presented at the age of five months with left hemiparesis and partial seizures. She developed infantile spasms at the age of 12 months. This is the first video clip report of partial seizures triggering symmetrical spasms in series, secondary to a basal ganglia glioma extending to the cortex. [Published with video sequences].
authors.affiliation: Division of Neurology, The Hospital for Sick Children, University of Toronto, Canada.
authors.forename: Rajesh
authors.initials: R
authors.lastname: RamachandranNair
authors.forename: Ayako
authors.initials: A
authors.lastname: Ochi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: David J
authors.initials: DJ
authors.lastname: Buckley
authors.forename: Teesta B
authors.initials: TB
authors.lastname: Soman
authors.forename: Shelly K
authors.initials: SK
authors.lastname: Weiss
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Otsubo
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001254:Astrocytoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D003342:Corpus Striatum / Q000473:pathology* / Q000503:physiopathology; D002658:Developmental Disabilities / Q000209:etiology; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000209:etiology*; D005917:Globus Pallidus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D010291:Paresis / Q000209:etiology; D013036:Spasms, Infantile / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D015173:Supratentorial Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants