title: A new mitochondrial RNA deletion fragment accelerated by oxidative stress in rat L6 cells.
abstract: RNA deletions may be easier to detect and more extensive than DNA deletions. Two large deletion fragments (1120 and 7811 bp) of mitochondrial RNA were observed in rat L6 muscle cells. At the site of the 1120 bp deletion, the remaining RNA fragment was re-linked by a short additional section (GGTATGAAGCT). These kinds of deletions were accelerated by oxidative stress and were not observed in mitochondrial DNA.
authors.affiliation: Department of Anatomy, Southern Medical University, Guangzhou, China.
authors.forename: Xiao-Zhong
authors.initials: XZ
authors.lastname: Qiu
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Zhang
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Qin
authors.forename: Hua
authors.initials: H
authors.lastname: Liao
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Ouyang
mesh_terms: D000818:Animals; D002460:Cell Line; D004272:DNA, Mitochondrial / Q000235:genetics; D018384:Oxidative Stress; D012313:RNA / Q000235:genetics*; D000077278:RNA, Mitochondrial; D051381:Rats; D017384:Sequence Deletion
chemical_list: D004272:DNA, Mitochondrial; D000077278:RNA, Mitochondrial; D012313:RNA