The L-type calcium channel in the heart: the beat goes on.
Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.
Bodi
Ilona
I
Institute of Molecular Pharmacology and Biophysics, University of Cincinnati College of Medicine, Ohio 45267, USA.
Mikala
Gabor
G
Koch
Sheryl E
SE
Akhter
Shahab A
SA
Schwartz
Arnold
A
D020816:Amino Acid Motifs; D000818:Animals; D001281:Atrial Fibrillation; D002118:Calcium / Q000378:metabolism; D020746:Calcium Channels, L-Type / Q000502:physiology*; D002147:Calmodulin / Q000737:chemistry / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000166:cytology; D020033:Protein Isoforms; D017434:Protein Structure, Tertiary; D014018:Tissue Distribution
D020746:Calcium Channels, L-Type; D002147:Calmodulin; D020033:Protein Isoforms; D002118:Calcium