Immunosuppressive iridoids from the fruits of Gardenia jasminoides.
A new iridoid, gardaloside (1), and a new safranal-type monoterpene, jasminoside G (2), together with 10 known compounds including nine iridoids and a second safranal-type monoterpene, were isolated from the fruits of Gardenia jasminoides. The structures of 1 and 2 were established on the basis of spectroscopic evidence. Of these compounds, geniposide (3), 6alpha-hydroxygeniposide (5), ixoroside (7), and shanzhiside (8) showed significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.
Chang
Wen-Liang
WL
School of Pharmacy, National Defense Medical Center, National Defense University, Taipei, Taiwan 114, Republic of China. wlchang@ndmctsgh.edu.tw
Wang
Hua-Ying
HY
Shi
Li-Shian
LS
Lai
Jenn-Haung
JH
Lin
Hang-Ching
HC
D000911:Antibodies, Monoclonal / Q000378:metabolism; D018106:CD28 Antigens / Q000378:metabolism; D005638:Fruit / Q000737:chemistry; D032062:Gardenia / Q000737:chemistry*; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007376:Interleukin-2 / Q000037:antagonists & inhibitors; D039823:Iridoids / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D039821:Monoterpenes; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000097:blood / Q000737:chemistry / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D013624:Taiwan; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D018106:CD28 Antigens; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D039823:Iridoids; D039821:Monoterpenes; D011714:Pyrans; C506506:gardaloside; C506507:jasminoside G; C007835:geniposide; D013755:Tetradecanoylphorbol Acetate