[Natural killer cells (CD56, CD16) as a factor of local antitumor immunity in breast cancer].
Two groups of malignancies with significantly distinct ratios of Ki-67 and CD16 expression were identified. Significant direct and inverse correlations between the markers were established (p < 0.01) whereas either group revealed two contradicting patterns of immune response. Whatever hormone receptor, natural killer cells (IKC) (CD16) levels correlated directly with tumor size and lymph node incidence (p < 0.01). IKC (CD56) did not contribute to breast tumor response. Our findings on CD16 expression may be used as criteria in prognosis prediction.
Ellinidi
V N
VN
Anikeeva
N V
NV
Goncharova
O A
OA
Krasnozhon
D A
DA
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology*; D019002:CD56 Antigen / Q000032:analysis* / Q000276:immunology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008207:Lymphatic Metastasis; D011237:Predictive Value of Tests; D011379:Prognosis; D017452:Receptors, IgG / Q000032:analysis* / Q000276:immunology
D014408:Biomarkers, Tumor; D019002:CD56 Antigen; D017452:Receptors, IgG