title: 5'-Porphyrin-oligonucleotide conjugates: neutral porphyrin-DNA interactions.
abstract: [chemical reaction: see text]. Incorporation of hydrophilic tetraarylporphyrin phosphoramidites into the 5'-termimus of the DNA as well as noncharged porphyrin-DNA interactions have been studied. Porphyrin-modified oligonucleotides show lower melting temperatures than their unmodified analogues. Single-stranded DNA interacts more strongly with porphyrin and causes more intense chiral disturbance in the porphyrin environment than the corresponding double strand.
authors.affiliation: Department of Chemistry, Columbia University, New York, New York 10027, USA. milan.balaz@chem.ox.ac.uk
authors.forename: Milan
authors.initials: M
authors.lastname: Balaz
authors.forename: Jay D
authors.initials: JD
authors.lastname: Steinkruger
authors.forename: George A
authors.initials: GA
authors.lastname: Ellestad
authors.forename: Nina
authors.initials: N
authors.lastname: Berova
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009841:Oligonucleotides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D011166:Porphyrins; C434331:phosphoramidite; D004247:DNA