Influence of cellulose powder structure on moisture-induced degradation of acetylsalicylic acid.
The stability of crystalline acetylsalicylic acid (ASA) powder in binary mixtures with cellulose powders was investigated to reveal information about the influence of the cellulose structural properties on the moisture-induced ASA degradation. Different cellulose powder samples were manufactured and characterized by X-ray diffraction and N2 BET gas adsorption. The degradation patterns in ASA/cellulose mixtures were monitored as a function of salicylic acid increase versus time under various relative humidity conditions at 50 degrees C. The crystallinity index of cellulose samples varied between approximately 49 and 95%. The results indicated that cellulose powder with the lowest crystallinity index exhibited lower degradation rates than the samples with the higher crystallinity index. It should be noted that higher ASA degradation rates were observed in the samples with comparably lower moisture contents. This effect was most pronounced in the 1:3 (w/w), ASA/cellulose mixtures, whereas in 3:1 (w/w), ASA/cellulose mixtures the effect was less obvious. The findings emphasise the importance of cellulose structural organisation when governing the moisture's partition between cellulose and ASA during the hydrolytic degradation.
Mihranyan
A
A
Department of Pharmacy, BMC, Uppsala University, Box 580, 75123 Uppsala, Sweden. Albert.Mihranyan@farmaci.uu.se
Strømme
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M
Ek
R
R
D001241:Aspirin / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D003461:Crystallography; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D006813:Humidity; D015394:Molecular Structure; D011208:Powders / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry*
D005079:Excipients; D011208:Powders; D014867:Water; D002482:Cellulose; C109691:microcrystalline cellulose; D001241:Aspirin