title: Association between cellular human immunodeficiency virus DNA level and immunological parameters in patients with undetectable plasma viremia level during highly active antiretroviral therapy.
abstract: The association between human immunodeficiency virus (HIV) DNA load and immunologic parameters was investigated in 163 HIV-infected patients with undetectable plasma viremia during highly active antiretroviral therapy (HAART). Patients with HIV DNA below the 25th percentile (133 copies/10(6) peripheral blood mononuclear cells) had higher pre-HAART (P = 0.001) and current (P = 0.005) CD4 counts and a prolonged duration of treatment (P = 0.001). At adjusted analysis, prolonged duration of treatment was independently associated with lower (P = 0.006) and undetectable (P < 0.001) HIV DNA values.
authors.affiliation: Department of Public Health and Cellular Biology, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Sarmati
authors.forename: Saverio Giuseppe
authors.initials: SG
authors.lastname: Parisi
authors.forename: Emanuele
authors.initials: E
authors.lastname: Nicastri
authors.forename: Gabriella
authors.initials: G
authors.lastname: d'Ettorre
authors.forename: Lucia
authors.initials: L
authors.lastname: Palmisano
authors.forename: Mauro
authors.initials: M
authors.lastname: Andreotti
authors.forename: Carolina
authors.initials: C
authors.lastname: Andreoni
authors.forename: Marina
authors.initials: M
authors.lastname: Giuliano
authors.forename: Francesca
authors.initials: F
authors.lastname: Gatti
authors.forename: Caterina
authors.initials: C
authors.lastname: Boldrin
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Vullo
authors.forename: Stefano
authors.initials: S
authors.lastname: Vella
authors.forename: Massimo
authors.initials: M
authors.lastname: Andreoni
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014766:Viremia / Q000188:drug therapy / Q000276:immunology / Q000821:virology*
chemical_list: D004279:DNA, Viral