[Hepatotoxicity caused by antituberculosis drugs in pediatrics].
The clinical profile of hepatotoxicity induced by tuberculosis drugs varies and the re-introduction of therapy for patients who developed this condition is controversial.5 pediatric cases treated throughout a period of 10 years in the Pediatric Department of Hipolito Unanue National Hospital are presented.2 individuals showed an asymptomatic increase of transaminases, 2 individuals had hepatitis, and 1 individual had acute liver failure. Most patients were female school students. Malnutrition and therapy continuation once the hepatic damage was started were found to be the risk factors.A staged reintroduction scheme for these agents after recovery from hepatitis is proposed.
Reto Valiente
Luz Victoria
LV
Departamento de Pediatría del Hospital Nacional Hipólito Unanue.
Castillo Vergara
José
J
Pichilingue Reto
Patricia
P
Pichilingue Prieto
Oscar Alfredo
OA
D000293:Adolescent; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies
D000995:Antitubercular Agents