title: Kinetics of interaction of local anesthetics with human serum albumin.
abstract: We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible process; equilibrium was attained within 1.5-4.5 h depending on chemical nature of local anesthetics.
authors.affiliation: Krasnodar Division of Southern Bureau, Russian Academy of Medical, Moscow.
authors.forename: A P
authors.initials: AP
authors.lastname: Galenko-Yaroshevskii
authors.forename: P N
authors.initials: PN
authors.lastname: Fistunenko
authors.forename: A S
authors.initials: AS
authors.lastname: Dukhanin
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry; D002045:Bupivacaine / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008012:Lidocaine / Q000737:chemistry; D012709:Serum Albumin / Q000737:chemistry*; D013748:Tetracaine / Q000737:chemistry
chemical_list: D000779:Anesthetics, Local; D001562:Benzimidazoles; C507880:RU 353; C492532:RU-1117; D012709:Serum Albumin; D013748:Tetracaine; D008012:Lidocaine; D002045:Bupivacaine