[Adult-onset Still disease with hemophagocytic syndrome treated with cyclosporine].
BACKGROUND
Adult-onset Still disease can have severe manifestations, the treatment of which is not yet codified.


METHODS
The authors report a case of life-threatening adult-onset Still disease with hemophagocytic syndrome, which improved dramatically with cyclosporin A. Despite the presence of severe pancytopenia, adult-onset Still disease is suggested by the combination of sore throat, myalgia, rash, hepatitis, high serum ferritin, low glycosylated ferritin, and negative etiologic findings.


CONCLUSIONS
Still disease may be present in patients with febrile pancytopenia, and cyclosporine may be a useful treatment after corticosteroid failure.
Hamidou
M
M
Service de médecine interne, CHU Hôtel-Dieu, Nantes (44). mohamed.hamidou@chu-nantes.fr
Boutoille
D
D
Masseau
A
A
Garand
R
R
Raffi
F
F
D018501:Antirheumatic Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology*; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D016572:Cyclosporine