title: Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation.
abstract: Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7 microM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 microM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kang
authors.forename: Ju
authors.initials: J
authors.lastname: Ryong Kim
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Sung-Gyu
authors.initials: SG
authors.lastname: Choi
authors.forename: Young-Han
authors.initials: YH
authors.lastname: Ryu
authors.forename: Goo
authors.initials: G
authors.lastname: Taeg Oh
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D029661:Alnus / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000473:pathology; D050197:Atherosclerosis / Q000473:pathology; D036381:Diarylheptanoids / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005638:Fruit / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000378:metabolism*; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D000097566:Cyclophanes
chemical_list: D000975:Antioxidants; D036381:Diarylheptanoids; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; C509355:acerogenin L; D000097566:Cyclophanes; C509356:garugamblin-3