title: Detection of Mycoplasma genitalium in women with laparoscopically diagnosed acute salpingitis.
abstract: OBJECTIVE
  Mycoplasma genitalium has been associated with cervicitis, endometritis, and tubal factor infertility. Because the ability of this bacterium to ascend and infect the fallopian tube remains undefined, we performed an investigation to determine the prevalence of M genitalium in fallopian tube, endometrial, and cervical specimens from women laparoscopically diagnosed with acute salpingitis in Nairobi, Kenya.
  
  
  METHODS
  Women presenting with pelvic inflammatory disease were laparoscopically diagnosed with salpingitis. Infection with M genitalium in genital specimens was determined by polymerase chain reaction (PCR).
  
  
  RESULTS
  Of 123 subjects with acute salpingitis, M genitalium was detected by PCR in the cervix and/or endometrium in nine (7%) participants, and in a single fallopian tube specimen. In addition, those infected with M genitalium were more often HIV infected than women not infected by M genitalium (seven of nine (78%) v 42 of 114 (37%), p<0.03).
  
  
  CONCLUSIONS
  M genitalium is able to ascend into the fallopian tube, but its association with tubal pathology requires further investigation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Washington, Seattle, USA. ccohen@psg.ucsf.edu
authors.forename: C R
authors.initials: CR
authors.lastname: Cohen
authors.forename: N R
authors.initials: NR
authors.lastname: Mugo
authors.forename: S G
authors.initials: SG
authors.lastname: Astete
authors.forename: R
authors.initials: R
authors.lastname: Odondo
authors.forename: L E
authors.initials: LE
authors.lastname: Manhart
authors.forename: J A
authors.initials: JA
authors.lastname: Kiehlbauch
authors.forename: W E
authors.initials: WE
authors.lastname: Stamm
authors.forename: P G
authors.initials: PG
authors.lastname: Waiyaki
authors.forename: P A
authors.initials: PA
authors.lastname: Totten
mesh_terms: D000208:Acute Disease; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D009175:Mycoplasma Infections / Q000175:diagnosis*; D045704:Mycoplasma genitalium / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction / Q000379:methods; D011446:Prospective Studies; D012488:Salpingitis / Q000175:diagnosis* / Q000382:microbiology