title: Synchronous bilateral ductal carcinoma in situ of the male breast associated with gynecomastia in a 30-year-old patient following repeated injections of stanozolol.
abstract: We report a rare case of synchronous bilateral and multifocal ductal carcinoma in situ (DCIS) in a 30-year-old patient operated on for gynecomastia following repeated injections of stanozolol, a non-aromatizable androgen. The familial medical history was negative for breast cancer and work-up of serum hormone levels was normal. The patient underwent a modified radical mastectomy without axilla dissection 6 weeks following the primary procedure and recovered uneventfully. The role of synthetic androgens in the development of male breast neoplasia warrants further scrutiny.
authors.affiliation: Department of Surgery, Spital Uster, Uster, Switzerland.
authors.forename: Ralph F
authors.initials: RF
authors.lastname: Staerkle
authors.forename: Philipp M
authors.initials: PM
authors.lastname: Lenzlinger
authors.forename: Stephan L
authors.initials: SL
authors.lastname: Suter
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Varga
authors.forename: Gian A
authors.initials: GA
authors.lastname: Melcher
authors.forename: A
authors.initials: A
authors.lastname: Melcher
mesh_terms: D000328:Adult; D000728:Androgens / Q000008:administration & dosage / Q000009:adverse effects*; D001365:Axilla; D018567:Breast Neoplasms, Male / Q000209:etiology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000209:etiology* / Q000601:surgery; D006177:Gynecomastia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008408:Mastectomy; D013197:Stanozolol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000728:Androgens; D013197:Stanozolol