Comparison of verapamil and cimetidine for their effects on volume and acidity of Carbachol induced gastric secretion in fasting rabbits.
BACKGROUND
Peptic ulcer is a common ailment for which over production of gastric acid is the main cause. This study was undertaken to find out the effects of Calcium channel blocker Verapamil and Cimetidine on volume and acidity of Carbacol induced gastric section, free and total acidity of carbachol induced gastric secretion and their effects were also compared.


METHODS
Thirty rabbits of local breed weighing 1-1.5kg were used. The animals were kept on fasting for 48 hours after which the pylorus of each was ligated. Verapamil 10mg/kg, Cimetidine 2.5 mg/kg and Carbachol 600 microg/kg body weight were administered intrapertoneally in pylorus ligated rabbits.


RESULTS
It was found that Verapamil reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Cimetidine also had the same effects. when the difference of means values brought about by verapamil were compared with those of Cimetidine, all these differences were found statistically non significant, indicating that Verapamil has similar effect as that of Cimetidine on all parameters included in study.


CONCLUSIONS
Verapamil has significant effect on volume and acidity of carbachol induced gastric secretion.
Jan
Muhammad
M
Department of Pharmacology, Saidu Medical College, Swat, Pakistan.
Orakzai
Shaukat Ali
SA
Tariq
Shafique
S
Javid
Muhammad
M
Ahmad
Shafiq
S
Haroon
Muhammad
M
Qamar
Muhammad
M
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002217:Carbachol; D002927:Cimetidine / Q000494:pharmacology*; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D002217:Carbachol; D014700:Verapamil