Novel gene therapeutic strategies for neurodegenerative diseases.
The convergent pathobiologic model of Parkinson's disease stipulates that disparate insults initiate a disease process that obligately share a common pathway leading to cell death. A combinatorial treatment which targets various steps in this pathway is likely to be the most successful therapeutic strategy. As advances are made in the field of neuroimaging and pharmacogenomics, early detection of sporadic PD will become a reality. Early intervention will likely spare more dopaminergic neurons and extend the quality of life for the patient. Continued advancements in the fields of pharmacology, neurosurgery, and gene therapy will strengthen the armamentarium available for the treatment of PD patients.
Maguire-Zeiss
K A
KA
Center for Aging and Developmental Biology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA. Kathleen_maguirezeiss@urmc.rochester.edu
Federoff
H J
HJ
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000628:therapy*; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D010300:Parkinson Disease / Q000235:genetics / Q000628:therapy
D000975:Antioxidants; D018696:Neuroprotective Agents; D004298:Dopamine