[Cytogenetic analysis of spermatozoa in a patient with chromosome constitution 45,X/46,X,r(Y) by intracytoplasmic injection into mouse oocytes].
The chromosome set of human spermatozoa was studied by intracytoplasmic injection into mouse oocytes. A total of 85 metaphase plates of male pronuclei of a patient with chromosome constitution 46,X,r(Y)/45,X and 108 metaphase plates of patients with normal sperm parameters (control group) were examined. The ratio between X- and Y-bearing chromosomes in the 46,X,r(Y)/45,X patient and in the control group did not differ from 1:1. A significant increase in the rates of diploidy, hypoploidy, hyperploidy of sex chromosomes, and chromosome structure rearrangements in spermatozoa of the patient in comparison with spermatozoa in the control group was recorded.
Fedorova
I D
ID
Kuznetsova
T V
TV
Van der Elst
J
J
Dhont
M
M
Baranov
V S
VS
D000328:Adult; D000818:Animals; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007248:Infertility, Male; D007621:Karyotyping; D008297:Male; D051379:Mice; D009865:Oocytes; D011003:Ploidies; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa