title: Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer.
abstract: Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.
authors.affiliation: College of Medicine, Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, ROC.
authors.forename: Ya-Shih
authors.initials: YS
authors.lastname: Tseng
authors.forename: Ching-Cherng
authors.initials: CC
authors.lastname: Tzeng
authors.forename: Chi-Ying F
authors.initials: CY
authors.lastname: Huang
authors.forename: Ping-Hong
authors.initials: PH
authors.lastname: Chen
authors.forename: Allen Wen-Hsiang
authors.initials: AW
authors.lastname: Chiu
authors.forename: Pei-Yin
authors.initials: PY
authors.lastname: Hsu
authors.forename: Guan-Cheng
authors.initials: GC
authors.lastname: Huang
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Wang
authors.forename: Hsiao-Sheng
authors.initials: HS
authors.lastname: Liu
mesh_terms: D001151:Arsenic / Q000633:toxicity; D064127:Aurora Kinases; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D003062:Codon; D019353:Endemic Diseases; D011905:Genes, ras; D006801:Humans; D009154:Mutation; D016491:Peripheral Vascular Diseases / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D003062:Codon; D012333:RNA, Messenger; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D001151:Arsenic