title: [Penetrating keratoplasty for treatment of fungal keratitis with corneal perforation].
abstract: OBJECTIVE
  To evaluate the outcome of penetrating keratoplasty (PKP) for the treatment of fungal keratitis with corneal perforation.
  
  
  METHODS
  40 patients (40 eyes) with corneal perforation secondary to fungal keratitis underwent PKP at Qingdao Eye Hospital from 1994 to 2003. The follow-up ranged from 6-24 months. The postoperative visual acuity and complications were documented.
  
  
  RESULTS
  39 (97.5%) patients preserved the eyeballs. The visual acuity improved in 38 (95.0%) eyes. Fungal infection recurred in 4 eyes, 3 of which were controlled with antifungal medication and 1 was enucleated because of the uncontrolled endophthalmitis. Graft rejection was observed in 15 (37.5%) eyes, 12 of which were cured with medication and 3 received secondary PKP. 3 (7.5%) eyes had graft ulceration, 2 of which were cured and the other one was regrafted because of severe endothelial cell loss. 5 (12.5%) eyes had secondary glaucoma, and the intraocular pressure was controlled medically and surgically. Complicated cataract occurred in 5 (12.5%) eyes, 3 of which underwent cataract extraction. Most complications were controlled successfully. At last follow-up, 36 (90.0%) grafts were clear.
  
  
  CONCLUSIONS
  PKP is an effective approach for preservation of eyeballs and restoration of visual function in patients eyes with fungal keratitis and corneal perforation.
authors.affiliation: Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China. lixinxie@public.qd.sd.cn
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Xie
authors.forename: Hua-lei
authors.initials: HL
authors.lastname: Zhai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D057112:Corneal Perforation / Q000601:surgery*; D003320:Corneal Ulcer / Q000382:microbiology / Q000601:surgery*; D015821:Eye Infections, Fungal / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity; D055815:Young Adult