Chromosomal inversion discovered in C3H/HeJ mice.
Mice of the inbred mouse strain C3H/HeJ have been shown to be homozygous for a chromosomal inversion on Chromosome (Chr) 6. The inversion encompasses about 20% of the chromosome from approximately 73 Mb to approximately 116 Mb. The importance of this finding is that linkage crosses using C3H/HeJ will show no recombination in this region of Chr 6. The inversion has no apparent effect on the phenotype of C3H/HeJ mice and its presence should not affect biological studies; however, use of C3H/HeJ mice for genetic analysis of Chr 6 should be avoided or the results interpreted with the inversion in mind. The inversion has been named In(6)1J (inversion Chr 6, Jackson 1).
Akeson
Ellen C
EC
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Donahue
Leah Rae
LR
Beamer
Wesley G
WG
Shultz
Kathy L
KL
Ackert-Bicknell
Cheryl
C
Rosen
Clifford J
CJ
Corrigan
Jennifer
J
Davisson
Muriel T
MT
D000818:Animals; D007446:Chromosome Inversion; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*