title: The utility of capsule endoscopy and its role for diagnosing pathology in the gastrointestinal tract.
abstract: BACKGROUND
  Capsule endoscopy (CE) is a new device that enables visualization of areas of the small bowel that were previously inaccessible through other noninvasive procedures. The purpose of this study is to evaluate this new diagnostic tool and its efficacy in finding occult GI tract pathology.
  
  
  METHODS
  A single-institution retrospective review was completed on patients undergoing CE from January 2002 to September 2004. Data evaluated included indications for CE, results of previous studies, CE findings, and complications of the CE study.
  
  
  RESULTS
  A total of 702 CE studies in 652 patients were performed during the study period. Suspicious GI bleeding presenting as anemia, guaiac positive stools, or history of gross bleeding were the most common reasons to perform CE (75.8%). Other indications included abdominal pain (11.5%), diarrhea (3.1%), or others (9.5%). In studies performed for GI bleeding (N = 532), a source was found in 49.3% of CE studies. Arteriovenous malformation (AVM) was the most common reported finding (43.9%), followed by ulcer (24.1%), colon or gastric pathology (14.1%), mass/tumor (9.1%), and stricture (6.9%). Patients with abdominal pain (n = 81) had findings 46.9% of the time including edema/ulcer (47.4%), stricture (10.5%), mass/tumor (26.3%), gastric pathology (10.5%), AVM (2.6%), or sprue (2.6%). Patients with diarrhea (n = 22) had findings 45.5% of the time including edema/ulcer (75%), mass/tumor (12.5%), or sprue (12.5%). A total of 66 patients underwent operative exploration after a CE study at this institution either because of the observed findings or for other reasons. There were 12 (1.7%) CE studies in which the capsule was retained and required surgical removal. Pathology at the retention site included benign strictures or adhesions (n = 9, 75%), Crohn's stricture (n = 1, 8.3%) carcinoid tumor (n = 1, 8.3%), and villous adenoma (n = 1, 8.3%).
  
  
  CONCLUSIONS
  CE is an accurate study to locate abnormalities in the GI tract that may have either been missed by previous diagnostic studies or cannot be observed through other non-invasive means. When used for diagnostic challenges such as GI bleeding with no apparent source, CE can be helpful in guiding surgical decisions in patients and thus should be integrated as part of the diagnostic workup.
authors.affiliation: Department of Surgery and Gastroenterology, University Medical Center, 3409 Worth Street, Suite 420, Dallas, TX 75246, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Carlo
authors.forename: Daniel
authors.initials: D
authors.lastname: DeMarco
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Smith
authors.forename: Sheryl
authors.initials: S
authors.lastname: Livingston
authors.forename: Kim
authors.initials: K
authors.lastname: Wiser
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kuhn
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Lamont
mesh_terms: D016099:Endoscopy, Gastrointestinal / Q000379:methods / Q000706:statistics & numerical data*; D004867:Equipment Design; D005767:Gastrointestinal Diseases / Q000175:diagnosis*; D006801:Humans; D008904:Miniaturization; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013686:Telemetry / Q000295:instrumentation*