title: Cognitive correlates of brain MRI subcortical signal hyperintensities in non-demented elderly.
abstract: OBJECTIVE
  To investigate the relationship between magnetic resonance imaging (MRI) subcortical gray and capsular (SGCH) and white matter hyperintensities (WMH) and cognitive functions in non-demented community dwelling elderly.
  
  
  METHODS
  The severity of SGCH and WMH on proton density and T2 MR images in 16 subjects was scored using the semi-quantitative rating scale of Scheltens et al. (1993). A limited series of cognitive tests selected a priori were then correlated with severity of SGCH and WMH.
  
  
  RESULTS
  Analysis demonstrated that severity of SGCH was inversely related to performance on the Digit Span (R = -0.64, p < 0.01) and the Stroop Color Word Tests (R = -0.64, p < 0.01). Severity of WMH was related to worsening performance on the Trail Making Test (R = 0.67, p < 0.005).
  
  
  CONCLUSIONS
  These findings indicate that severity of WMH is negatively related to more pure executive cognitive functions, specifically set shifting, while severity of SGCH is inversely related to more basic functions of attention and working memory.
authors.affiliation: Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Gad A
authors.initials: GA
authors.lastname: Marshall
authors.forename: Rick
authors.initials: R
authors.lastname: Hendrickson
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Kaufer
authors.forename: Larry S
authors.initials: LS
authors.lastname: Ivanco
authors.forename: Nicolaas I
authors.initials: NI
authors.lastname: Bohnen
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology* / Q000502:physiology*; D003071:Cognition; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011581:Psychological Tests