title: Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
abstract: A series of dinaphtho[1,2-b;2',3'-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.
authors.affiliation: Division of Bio-Organic Science, Korea Research Institute of Chemical Technology, Daejeon 305-353, Republic of Korea.
authors.forename: Kee-In
authors.initials: KI
authors.lastname: Lee
authors.forename: Youmie
authors.initials: Y
authors.lastname: Park
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Hwang
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Gun-Do
authors.initials: GD
authors.lastname: Kim
authors.forename: Woo-Kyu
authors.initials: WK
authors.lastname: Park
authors.forename: Sunghou
authors.initials: S
authors.lastname: Lee
authors.forename: Daeyoung
authors.initials: D
authors.lastname: Jeong
authors.forename: Jae-Yang
authors.initials: JY
authors.lastname: Kong
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.forename: Heeyeong
authors.initials: H
authors.lastname: Cho
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D005663:Furans; D009285:Naphthoquinones; D011799:Quinazolines; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor