[Various approaches of therapeutic vaccination for the treatment of HIV type 1 infection].
HIV-1 infection is a major pandemic situation. With the advent of highly active antiretroviral therapy (HAART), morbidity and mortality associated with HIV-1 infection have been dramatically reduced. However, HAART does not enable eradication of the virus. The efficacy of these new regimens is limited by problems over long-term use such as toxicity and resistance. Therapeutic vaccination is an alternative approach to HIV-1 infection. The main aim is to boost and reinforce virus-specific host immune responses. Several immunogens and schedules of immunization have been tested. In this review, various strategies designed for therapeutic vaccines for HIV-1 infection are presented.
Lazrek
M
M
Service de virologie, UPRES EA 3610, CHRU de Lille.
Lobert
P E
PE
Goffard
A
A
Schanen
C
C
Dewilde
A
A
Bocket
L
L
Hober
D
D
D016915:AIDS Vaccines / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans
D016915:AIDS Vaccines