title: Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates.
abstract: PAMAM dendrimer-RGD-4C peptide conjugate was synthesized and in vitro targeting efficacy to integrin receptor expressing cells was studied by flow cytometry and confocal microscopy.
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Science, Department of Internal Medicine, Division of Allergy, University of Michigan, Ann Arbor, 48109, USA.
authors.forename: Rameshwer
authors.initials: R
authors.lastname: Shukla
authors.forename: Thommey P
authors.initials: TP
authors.lastname: Thomas
authors.forename: Jennifer
authors.initials: J
authors.lastname: Peters
authors.forename: Alina
authors.initials: A
authors.lastname: Kotlyar
authors.forename: Andrzej
authors.initials: A
authors.lastname: Myc
authors.forename: James R
authors.initials: JR
authors.lastname: Baker
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D050091:Dendrimers; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy*; D009389:Neovascularization, Pathologic; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism*; D011073:Polyamines / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020533:Angiogenesis Inhibitors; D050091:Dendrimers; D016023:Integrins; D009842:Oligopeptides; C104700:PAMAM Starburst; D011073:Polyamines; C047981:arginyl-glycyl-aspartic acid