title: Late recurrence of uterine Mullerian adenosarcoma as heterologous sarcoma: Three recurrences in 8 months increasing in number and grade of sarcomatous components.
abstract: BACKGROUND
  Uterine Mullerian adenosarcoma (UMA) is a rare and low-grade variant of mixed mesodermal tumor. UMA recurrences including heterologous sarcomatous elements are extremely rare, with only 3 cases reported thus far.
  
  
  METHODS
  We present a case of UMA recurring as heterologous sarcoma three times in 8 months for 9.4 years after primary treatment. The number and grade of sarcomatous components increased with each recurrence eventually resulting in loss of the patient.
  
  
  CONCLUSIONS
  The presence of multiple sarcomatous elements of high histological grade in the recurrent tumor following UMA may indicate an unfavorable prognosis with common recurrences and fatal outcome. All UMA patients carry risk of late recurrence, therefore, they should receive long-term follow-up.
authors.affiliation: Department of Obstetric and Gynecology, Ankara University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Taçkin
authors.forename: Elif Aylin
authors.initials: EA
authors.lastname: Bozaci
authors.forename: Murat
authors.initials: M
authors.lastname: Sönmezer
authors.forename: Cemil
authors.initials: C
authors.lastname: Ekinci
authors.forename: Firat
authors.initials: F
authors.lastname: Ortaç
mesh_terms: D018195:Adenosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*