Three new diterpene alkaloids from the roots of Aconitum nagarum var. lasiandrum.
Three new diterpene alkaloids, 16,17-dihydro-12 beta,16 beta-epoxynapelline (1), N-deethyl- N-methyl-12-epi-napelline (2) and 11- epi-16 alpha,17-dihydroxylepenine (3), along with twenty-six known alkaloids (4 - 29) were isolated from the roots of Aconitum nagarum var. lasiandrum. The chemical structures of the new compounds were established by HR-MS as well as 1D- and 2D-NMR spectroscopic analysis. The absolute stereochemistry of 1 was confirmed by X-ray crystallography.
Zhang
Fan
F
Chengdu Institute of Biology, Chinese Academy of Sciences, PR China.
Peng
Shu-Lin
SL
Liao
Xun
X
Yu
Kai-Bai
KB
Ding
Li-Sheng
LS
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
C507343:11- epi-16 alpha,17-dihydroxylepenine; C507340:16,17-dihydro-12 beta,16 beta-epoxynapelline; D000470:Alkaloids; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C507342:N-deethyl- N-methyl-12-epi-napelline