Potent capillary isotachophoresis (cITP) for analyzing a marker of coronary heart disease risk and electronegative low-density lipoprotein (LDL) in small dense LDL fraction.
BACKGROUND
The potency and usefulness of capillary isotachophoresis (cITP) for assessing whole-serum lipoprotein profiles and quantifying electronegative low-density lipoprotein (LDL) has been previously reported.


RESULTS
A new cITP method to measure electronegative LDL in the small dense LDL fraction has been established. Both electronegative LDL and electronegative LDL in the small dense LDL fraction decreased after treatment with fenofibrate.


CONCLUSIONS
This method appears to be useful for analyzing a marker of coronary heart disease risk and may be suitable for evaluating the effects of hypolipidemic agents.
Noda
Keita
K
Department of Cardiology, Fukuoka University School of Medicine, Japan.
Zhang
Bo
B
Uehara
Yoshinari
Y
Miura
Shin-ichiro
S
Matsunaga
Akira
A
Saku
Keijiro
K
D015415:Biomarkers / Q000097:blood; D011232:Chemical Precipitation; D003327:Coronary Disease / Q000175:diagnosis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D011345:Fenofibrate / Q000494:pharmacology / Q000627:therapeutic use; D006493:Heparin; D006801:Humans; D006953:Hyperlipoproteinemia Type IV / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D012306:Risk
D015415:Biomarkers; D008077:Lipoproteins, LDL; D006493:Heparin; D011345:Fenofibrate