DNA ligases are specifically inhibited by anthracyclines with a free 3'-amino group.
Montecucco
A
A
Istituto di Genetica Biochimica ed Evoluzionistica, C.N.R., Università di Pavia, Italy.
Pedrali-Noy
G
G
Spadari
S
S
Zanolin
E
E
Chiesa
M T
MT
Ciarrocchi
G
G
D000588:Amines; D018943:Anthracyclines / Q000737:chemistry / Q000494:pharmacology*; D017122:Bacteriophage T4 / Q000187:drug effects / Q000201:enzymology; D002470:Cell Survival / Q000187:drug effects; D011088:DNA Ligases / Q000037:antagonists & inhibitors*; D004278:DNA, Superhelical / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D059004:Topoisomerase I Inhibitors
D000588:Amines; D018943:Anthracyclines; D004278:DNA, Superhelical; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; D011088:DNA Ligases