[Evaluation of the response to vaccination against poliomyelitis and measles in malnourished children in Morocco].
We made a comparative survey of the poliovirus antibodies (anti-poliovirus type 1, anti-poliovirus type 2 and anti-poliovirus type 3) and the measles antibodies in malnourished but completely vaccinated children (37) and control children (34). The age range was 10 months to 5 years. Immunization in children with protein-energy malnutrition was low for both vaccines. Seroprevalence rates of the polio 1, polio 2, polio 3 antibodies and the measles antibodies in the control group were 94.1%, 97.1%, 91.2% and 82.4% respectively. In malnourished children the respective rates were in some cases significantly lower being: 40.5% (P = 0.001), 59.5% (P = 0.001), 40.5% and 35.1%. Malnutrition is a major determinant of the humoral response to oral polio and measles vaccines and must be given due consideration to prevent vaccination failure.
Caidi
H
H
Département d'Immuno-Virologie, Institut national d'Hygiène, Rabat, Maroc. hcaidi@mailcity.com
Bennis
I F
IF
Mouan
N
N
El Aouad
R
R
D017677:Age Distribution; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D016022:Case-Control Studies; D002648:Child; D015362:Child Nutrition Disorders / Q000097:blood / Q000150:complications* / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008297:Male; D008457:Measles / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D008459:Measles virus / Q000276:immunology; D009018:Morocco / Q000453:epidemiology; D011051:Poliomyelitis / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D017955:Poliovirus / Q000276:immunology; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000150:complications* / Q000276:immunology; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D017211:Treatment Failure; D014611:Vaccination / Q000592:standards*
D000914:Antibodies, Viral