title: Carbon nanohorns as anticancer drug carriers.
abstract: We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The released cisplatin was effective in terminating the growth of human lung-cancer cells, while the SWNHs themselves had no such effect. Cisplatin-incorporated oxidized SWNHs are thus a potential drug delivery system.
authors.affiliation: JST/SORST, c/o NEC, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan. kumikoajima@frl.cl.nec.co.jp
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ajima
authors.forename: Masako
authors.initials: M
authors.lastname: Yudasaka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Murakami
authors.forename: Alan
authors.initials: A
authors.lastname: Maigné
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Shiba
authors.forename: Sumio
authors.initials: S
authors.lastname: Iijima
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002244:Carbon; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000493:pharmacokinetics; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D008175:Lung Neoplasms
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D002244:Carbon; D002945:Cisplatin