Some molecular aspects in schistosomiasis mansoni and toxoplasmosis.
The IL-2 and IL-4 cytokines production represent cellular Th1 & Th2 immune responses respectively were associated with chronic schistosomiasis mansoni (stages 1-4) and chronic toxoplasmosis gondii. In the hepatosplenic schistosomiasis, the level of IL-2 and disease stage increased in parallel (P<0.05, <0.01, <0.01 & <0.001 in stages 1, 2, 3 & 4 respectively), whereas, IL-4 was highly significantly increased in stage 1 than control (P<0.001), then decreased to lower levels. The mean concentrations of IL-2 & IL-4 in patients with T. gondii were higher compared to control being more marked in IL-2 (P<0.001) versus IL-4 (P< 0.01). The data indicated that there are patterns of cytokine expression characteristic of type 1 & type 2 responses in vivo, with the ultimate goal of being able to manipulate the response to minimize inflammation and fibrosis for clinical benefit.
el-Shazly
Atef M
AM
Department of Parasitology, Faculty of Medicine, Mansoura University, Mansoura.
Azab
Manar S
MS
el-Beshbishi
Samar N
SN
el-Nahas
Hala A
HA
Abdel Magied
Aida A
AA
Abou el-Hasan
Mohamed
M
Monib
M el-Salahy M M
Mel-S
Morsy
Tosson A
TA
D000818:Animals; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000097:blood; D015847:Interleukin-4 / Q000096:biosynthesis / Q000097:blood; D008297:Male; D012555:Schistosomiasis mansoni / Q000276:immunology*; D012720:Severity of Illness Index; D014123:Toxoplasmosis / Q000276:immunology*
D007376:Interleukin-2; D015847:Interleukin-4