title: K channel expression in prostate epithelium and its implications in men with chronic prostatitis.
abstract: OBJECTIVE
  To investigate the effect of the Kv1.3 K(+) channel on the pathogenesis of chronic prostatitis.
  
  
  METHODS
  The expression of the Kv1.3 K(+) channel in prostatic epithelia was detected using streptavidin/peroxidase immunohistochemistry in tissue samples from 75 men with benign prostatic hyperplasia, including 42 with and 33 without chronic inflammation. All of the men were sampled in our hospital between January 2000 and December 2003.
  
  
  RESULTS
  There was strong and moderate immunostaining in 14 of the prostatic epithelial specimens with inflammation and in 21 from patients without inflammation, compared to 28 and 12 with low staining, respectively (chi-squared, P < 0.05).
  
  
  CONCLUSIONS
  The expression of the Kv1.3 K(+)channel was lower in prostatic epithelial cells from patients with chronic inflammation than from those without. Opening the Kv1.3 K(+) channel could promote the efflux of K(+) from the cells, causing an increase in [K(+)] in the prostate cavity. The increase in [K(+)] can then infiltrate the stroma through the epithelial gap, exciting the nerve fibres and causing pain and other clinical symptoms.
authors.affiliation: Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Chao-Zhao
authors.initials: CZ
authors.lastname: Liang
authors.forename: Qing-Kui
authors.initials: QK
authors.lastname: Guo
authors.forename: Zong-Yao
authors.initials: ZY
authors.lastname: Hao
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: De-Bin
authors.initials: DB
authors.lastname: Wang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wu
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Ke-Xiao
authors.initials: KX
authors.lastname: Wang
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D002908:Chronic Disease; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015221:Potassium Channels / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011472:Prostatitis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology
chemical_list: D015221:Potassium Channels