Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances.
Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is a protein component in wheat and other cereals, such as rye and barley. At present, the only available treatment is a strict gluten-free diet. Recent advances have increased our understanding of the molecular basis for this disorder. The past decade has seen new scientific developments in this disease and led to the formulation of new concepts of pathophysiology and clinical manifestations. There are several targets for new treatments. This article briefly summarizes the National Institutes of Health Consensus Statement and gives an overview of new findings in recent years and of future therapeutic options for CD.
Gadewar
Swati
S
Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine, Health Science Facility II Room 8345, 20 Penn Street, Baltimore, MD 21201, USA.
Fasano
Alessio
A
D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy / Q000209:etiology; D015975:Consensus Development Conferences, NIH as Topic; D005983:Glutens / Q000009:adverse effects*; D006801:Humans; D017410:Practice Guidelines as Topic; D014481:United States
D005983:Glutens