Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester.
A prospective clinical study in eastern Sudan described the efficacy and toxicity of quinine in early pregnancy in mothers with chloroquine-resistant falciparum malaria. Twenty-six pregnant Sudanese women in their first trimester (mean gestational age 8.5 weeks) were given quinine 10 mg/kg 3 times per day for 7 days and followed up every 2 weeks until delivery. One patient aborted (3.8%) and 2 patients (7.7%) experienced threatened abortion but delivered term babies. Recrudescence or re-infection was observed on day 21 in 1 patient. One baby died aged 6 months. There were no detectable congenital malformations, no auditory or visual defects or any other neurological deficits in the remaining infants at birth or 1 year later. Quinine may be safe in the first trimester of pregnancy.
Adam
I
I
New Halfa Hospital, New Halfa, Sudan.
Idris
H M
HM
Elbashir
M I
MI
D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002738:Chloroquine; D004351:Drug Resistance; D019353:Endemic Diseases; D005260:Female; D005865:Gestational Age; D006801:Humans; D007262:Infusions, Intravenous; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D010270:Parasite Egg Count; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D011803:Quinine / Q000627:therapeutic use*; D012008:Recurrence; D012449:Safety; D013397:Sudan / Q000453:epidemiology; D016896:Treatment Outcome
D000962:Antimalarials; D002738:Chloroquine; D011803:Quinine