title: [A clinical study of endoscopic local coagulation therapy for hepatocellular carcinoma (HCC)].
abstract: Eighteen subjects with cases of HCC who underwent endoscopic local coagulation therapy at Hiroshima City Hospital between 1998 and 2004 were studied and compared with 6 cases of HCC patients who underwent laparoscopic partial hepatectomy during the same period. The subjects composed of 10 cases of laparoscopic microwave coagulation therapy (L-MCT), 5 cases of laparoscopic radio frequency ablation therapy (L-RFA), and 3 cases of thoracoscopic microwave coagulation therapy (T-MCT). The operation time was 114 minutes for L-MCT and 92 minutes for L-RFA, both of which were significantly shorter than 208 minutes for resection cases. No complications were developed in any of the cases and the postoperative hospitalization period of the cases was 13.1 days, 8.2 days, and 13.0 days, respectively. Although each case of local recurrence was observed both in L-MCT and L-RFA groups, one case displayed observation difficulty from the liver surface and the other required a daughter nodule. The three-year survival rate was 71.4%, while the five-year survival rate was 53.6%. Endoscopic local coagulation therapy is not too invasive and useful for hepatocellular carcinoma in which percutaneous RFA is difficult. However, it is well indicated when the scope is evident with observation being feasible from the liver surface.
authors.affiliation: Dept. of Surgery, Hiroshima City Hospital.
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Shiozaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Nishitani
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamada
authors.forename: Hisami
authors.initials: H
authors.lastname: Okusha
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mimae
authors.forename: Takaoki
authors.initials: T
authors.lastname: Furukawa
authors.forename: Akito
authors.initials: A
authors.lastname: Morita
authors.forename: Youji
authors.initials: Y
authors.lastname: Kubo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Choda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nishizaki
authors.forename: Masao
authors.initials: M
authors.lastname: Harano
authors.forename: Hideki
authors.initials: H
authors.lastname: Aoki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Onoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Motoki
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Norihisa
authors.initials: N
authors.lastname: Takakura
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D004564:Electrocoagulation / Q000379:methods*; D016145:Endoscopy, Digestive System; D005260:Female; D006498:Hepatectomy; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D013906:Thoracoscopy