title: HLA genes in Lamas Peruvian-Amazonian Amerindians.
abstract: The Lamas Amerindians are the Chancas descents who established before 1532 a.d. (Spanish conquest) at Lamas City, Wayku quarter in a Peruvian-Amazonian province (San Martin). The Lamas HLA profile shows significant differences with other Amerindians HLA profile, i.e.: (a) a higher number of newly found haplotypes compared to other studied Amerindian populations, particularly HLA-A*02-B*48-DRB1*0403-DQB1*0302, A*02-B*48-DRB1*0804-DQB1*0402 and A*02-B*40-DRB1*0407-DQB1*0302; (b) a relative high frequency of HLA-DRB1*0901 (a high frequency southern Asian allele) and HLA-B*48 (a Na-Dene, Siberian and Eskimo allele); both alleles are also found frequently in Quechuas and Aymaras, but not in many other (particularly Meso American) Amerindians and (c) correspondence and neighbor-joining dendrogram analyses show that Lamas (Chancas) may have an origin close to Amazonian Indians that later reached the Andean altiplano.
authors.affiliation: Departments of Inmunologia and Medicina Interna, Hospital 12 Octubre, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Moscoso
authors.forename: Segundo
authors.initials: S
authors.lastname: Seclen
authors.forename: Juan I
authors.initials: JI
authors.lastname: Serrano-Vela
authors.forename: A
authors.initials: A
authors.lastname: Villena
authors.forename: Jorge
authors.initials: J
authors.lastname: Martinez-Laso
authors.forename: Jorge
authors.initials: J
authors.lastname: Zamora
authors.forename: Almudena
authors.initials: A
authors.lastname: Moreno
authors.forename: Juan
authors.initials: J
authors.lastname: Ira-Cachafeiro
authors.forename: Antonio
authors.initials: A
authors.lastname: Arnaiz-Villena
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D010568:Peru; D010802:Phylogeny
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains