title: [Unruptured intracranial aneurysm: possible therapeutic strategies?].
abstract: Intracranial unruptured aneurysm (ICUA) has become a common condition for patient consultation. The mortality rate after fissuration is estimated to be between 52% and 85.7%. The final therapeutic decision results from a balance between the risk of rupture and risks related to the aneurysmal exclusion. Analysis of the risk of rupture risk enables a classification of risk factors. Depending on the circumstances of diagnosis, we considered the ICUA at high risk of rupture for incidental ICUA larger than 7 mm and in the event of associated aneurysms. Classifying by morphologic features, high-risk ICUA were located in the vertebrobasilar system (RR: 4.4; 95%CI: 2.7-6.8), those with a size between 7 and 12 mm (RR: 3.3; 95%CO: 1.3-8.2), larger than 12 mm (RR: 17; 95%CI: 8-36.1), those that were multilobular or a larger size and those ones with a index P/L superior to 3.4 (risk x20). Familial ICUA would expose to a major rupture risk (2 to 7 times sporadic ICUA). Some systemic factors were related to ICUA rupture: arterial hypertension (RR: 1.46; 95%CI: 1.01-2.11) and smoking addiction (RR: 3.04; 95%CI: 1.21-7.66). After microsurgical exclusion, the morbidity and mortality rates were 10% and 2% respectively. Some microsurgical morbidity factors were identified: age (32%>65 years), size (14%>15 mm), vertebrobasilar location and temporary occlusion. The rupture incidence after microsurgical exclusion was estimated 0.26%/year. After endovascular exclusion, the morbidity and mortality rates were 8% and 1% respectively. The complete exclusion rate varied between 47% and 67%. The rupture risk was estimated at 0.9%/year. Treatment recommendations were classified into 3 categories.
authors.affiliation: Service de Neurochirurgie, CHU de Rouen. francois.proust@chu-rouen.fr
authors.forename: F
authors.initials: F
authors.lastname: Proust
authors.forename: S
authors.initials: S
authors.lastname: Derrey
authors.forename: B
authors.initials: B
authors.lastname: Debono
authors.forename: E
authors.initials: E
authors.lastname: Gérardin
authors.forename: A-C
authors.initials: AC
authors.lastname: Dujardin
authors.forename: D
authors.initials: D
authors.lastname: Berstein
authors.forename: F
authors.initials: F
authors.lastname: Douvrin
authors.forename: O
authors.initials: O
authors.lastname: Langlois
authors.forename: L
authors.initials: L
authors.lastname: Verdure
authors.forename: E
authors.initials: E
authors.lastname: Clavier
authors.forename: P
authors.initials: P
authors.lastname: Fréger
mesh_terms: D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D008866:Microsurgery; D017410:Practice Guidelines as Topic