2-Pyridin-2-yl-1H-indole derivatives: synthesis, estrogen receptor binding affinity, and photophysical properties.
A series of novel 2-pyridin-2-yl-1H-indole derivatives (4a-f) was prepared by intramolecular cyclodehydration of alpha-anilinyl (or 3-anisidyl)-2-pyridin-2-yl-ethanones (2a-f) and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. These compounds showed long wavelength fluorescent emission, which is sensitive to solvent polarity and pH, while indol-6-ols 4b, e, and f displayed reasonably good binding affinities to ER.
Kasiotis
Konstantinos M
KM
Chemistry Laboratory, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece.
Haroutounian
Serkos A
SA
D001667:Binding, Competitive; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000138:chemical synthesis / Q000378:metabolism; D008027:Light; D010777:Photochemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
D007211:Indoles; D011725:Pyridines; D011960:Receptors, Estrogen