title: [Chemotherapy for liver metastasis of colorectal cancer].
abstract: In colorectal cancer, liver metastasis is the most common and most important prognostic factor. Although surgical resection is the first choice of treatment for liver metastasis of colorectal cancer, there are many cases we cannot choose the surgical treatment. The chemotherapy is very important in such cases. We examined 18 cases of unresectable liver metastases from colorectal cancer which were adapted a hepatic arterial infusion of 5-FU (HAI) with a weekly high-dose infusion method (WHF) as the first-line treatment, and then systemic chemotherapy of CPT-11 in combination with 5-FU as the second-line treatment. The response rate of this treatment is 72% (13/18) and the 1-, 2-, 3-year survival rates were 100% (16/16), 83% (10/12), and 50% (5/10), respectively. The combination chemotherapy of HAI with systemic chemotherapy using CPT-11 seemed to be an effective treatment method.
authors.affiliation: Dept of Surgery, Nishinomiya Municipal Central Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Amano
authors.forename: Takahiro
authors.initials: T
authors.lastname: Niinobu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Itani
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Nishikawa
authors.forename: Sumiko
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Naozumi
authors.initials: N
authors.lastname: Higaki
authors.forename: Hirohito
authors.initials: H
authors.lastname: Hayashida
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujita
authors.forename: Masato
authors.initials: M
authors.lastname: Sakon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000473:pathology*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D005472:Fluorouracil; D002166:Camptothecin