title: [Experimental comparative study of bioactive composite with polymeric matrix for applications to oculoplastic surgery for tissue replacement].
abstract: OBJECTIVE
  To compare two new biomaterials: Composite 10% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil) and Composite 20% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil), with two similar materials as control: Medpor (Porex Surgical Inc.--USA) e Polipore (Homus Com. Ind. Ltda--BRASIL).
  
  
  METHODS
  In vivo randomized experimental double blind study: a transconjunctival approach was performed in both cartilaginous superior orbital walls of 28 rabbits for 56 implants divided into 4 groups: GI: Composite 10%/Medpor; GII: Composite 10%/Polipore; GIII: Composite 20%/Medpor; GIV: Composite 20%/Polipore. The mean rate for implant time of permanence was 19.7 weeks. The Student's t test was used for statistical analysis.
  
  
  RESULTS
  Revealed similar biocompatibility of all materials and none of the implants was extruded; one Composite 20% had partial exposure. Histomorphometry showed a greater bioactivity of the composites with significantly thicker fibrous encapsulation, with more collagen and fibroblasts, exuberant angiogenesis, and a lower inflammatory cell mean compared to controls. The presence of precipitation of a hydroxycarbonate apatite layer, which acts as an implant-tissue bond was confirmed. Composites presented a smaller tissular invasion index of the pores compared to controls.
  
  
  CONCLUSIONS
  The composites showed a good biocompatibility and some additional advantage over the Medpor and Polipore controls.
authors.affiliation: Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina, UFMG, Belo Horizonte, MG. valeniop@uai.com.br
authors.forename: Valênio Pérez
authors.initials: VP
authors.lastname: França
authors.forename: Ana Rosa Pimentel de
authors.initials: AR
authors.lastname: Figueiredo
authors.forename: Anilton César
authors.initials: AC
authors.lastname: Vasconcelos
authors.forename: Rodrigo Lambert
authors.initials: RL
authors.lastname: Oréfice
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D003188:Composite Resins / Q000627:therapeutic use*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D011897:Random Allocation; D019651:Plastic Surgery Procedures / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D003188:Composite Resins