Origins go plastic.
Replication origins should no longer be thought of as housekeeping elements that function similarly in all cell types. provide the most authoritative evidence to date that mammalian replication origins can be dynamically regulated during differentiation.
Gilbert
David M
DM
Department of Biochemistry and Molecular Biology, The State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D004261:DNA Replication / Q000235:genetics*; D018741:Replication Origin / Q000235:genetics / Q000502:physiology*