title: Treatment of large conjunctival nevus by resection and reconstruction using amniotic membrane.
abstract: BACKGROUND
  Nevus of the bulbar conjunctiva is a benign pigmented lesion of the ocular surface. Unless a biopsy is required for ruling out malignant melanoma, a nevus is usually excised for cosmetic reasons only. However, with large lesions involving two or more quadrants of the bulbar conjunctiva, a total resection can be difficult. In this report, we present a case of a huge nevus treated by surgical excision and amniotic membrane transplantation for reconstruction of the bulbar conjunctiva.
  
  
  METHODS
  A 54-year-old Japanese man was referred to our clinic with suspected malignant tumor of the bulbar conjunctiva in his right eye. A large and diffuse pigmented tumor with numerous small cysts was present mainly on the upper bulbar conjunctiva. Resection of the conjunctival tumor and amniotic membrane transplantation for reconstruction of the bulbar conjunctiva were performed.
  
  
  RESULTS
  The histopathological diagnosis was conjunctival nevus. Epithelialization of the bulbar conjunctiva over the amniotic membrane sheet was completed 4 weeks after resection. At 44-month follow-up, there was no recurrence or any postoperative complication.
  
  
  CONCLUSIONS
  Surgical resection combined with reconstruction by amniotic membrane transplantation is effective for the treatment of large conjunctival nevus.
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. machikotomita@yahoo.co.jp
authors.forename: Machiko
authors.initials: M
authors.lastname: Tomita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
authors.forename: Ryuji
authors.initials: R
authors.lastname: Muramatsu
authors.forename: Masahiko
authors.initials: M
authors.lastname: Usui
mesh_terms: D000650:Amnion / Q000637:transplantation*; D003230:Conjunctival Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures; D019651:Plastic Surgery Procedures