title: Oxygenated pimarane diterpenes from Kaempferia marginata.
abstract: Six new diterpenes, (1R,2S,5S,7S,9R,10S,13R)-1,2,7-trihydroxypimara-8(14),15-diene (1), (1R,2S,5S,9S,10S,11R,13R)-1,2,11-trihydroxypimara-8(14),15-diene (2), (1S,5S,7R,9R,10S,11R,13R)-1,7,11-trihydroxypimara-8(14),15-diene (3), (1S,5S,9S,10S,11R,13R)-1,11-dihydroxypimara-8(14),15-diene (4), (5S, 6R,9S,10S,13R)-6-hydroxypimara-8(14),15-diene-1-one (5), and (1R,2S,5S,7S,9R,10S,13R)-1,2-dihydroxypimara-8(14),15-diene-7-one (6), along with four known diterpenes, have been isolated from the dichloromethane extract of whole plants of Kaempferia marginata. The structures were assigned by spectroscopic methods. The absolute configuration of 1 was established by the Mosher ester method. Substances obtained were evaluated against a panel of bioassays including antimalarial, antituberculous, and antifungal activity.
authors.affiliation: Chulabhorn Research Institute, Vipavadee Rangsit Highway, Bangkok 10210, Thailand.
authors.forename: Sanit
authors.initials: S
authors.lastname: Thongnest
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Somyote
authors.initials: S
authors.lastname: Sutthivaiyakit
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010100:Oxygen / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D013237:Stereoisomerism; D013785:Thailand; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000935:Antifungal Agents; D000962:Antimalarials; D000995:Antitubercular Agents; D010100:Oxygen