title: A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females.
abstract: Recent studies suggest that inflammation may play an important role in the pathogenesis of Parkinson's disease (PD). Because the C(-260) --> T polymorphism in the promoter of the CD14 monocyte receptor gene (pCD14) could affect the predisposition to the inflammatory response, we conducted a case-control study to investigate a possible genetic susceptibility of the pCD14 polymorphism in patients with PD. This study included 200 sporadic PD patients and 200 controls, matched by sex and case-control pairs for age at onset in the case. All observed genotype frequencies were in Hardy-Weinberg equilibrium. Results revealed that the CD14-T allele of the pCD14 polymorphism in the female PD patients existed statistically significant difference from that of the female controls (OR = 1.262, P = 0.038), but not for male. Female individuals with homozygote CD14-TT genotype were significantly increased risk of PD by 1.28 time (P = 0.027). Furthermore, a logistic regression analysis confirmed that the homozygote CD14-TT genotype was an independent risk factor for PD (OR = 1.576, P = 0.030). In conclusion, results of this study indicate the pCD14 polymorphism to be a genetic risk factor for PD in females.
authors.affiliation: Department of Neurology, Chushang Show-Chwan Hospital, Nantou, 557, Taiwan, ROC. jjlinn@tcts.seed.net.tw
authors.forename: J J
authors.initials: JJ
authors.lastname: Lin
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.forename: K C
authors.initials: KC
authors.lastname: Yueh
authors.forename: C Y
authors.initials: CY
authors.lastname: Chang
authors.forename: S Z
authors.initials: SZ
authors.lastname: Lin
mesh_terms: D000368:Aged; D004247:DNA / Q000235:genetics; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012306:Risk; D012727:Sex Characteristics
chemical_list: D018950:Lipopolysaccharide Receptors; D004247:DNA