Evidence against a contribution of conventional urine risk factors to de novo ESRD renal stones.
BACKGROUND
The authors measured urine and blood stone risk factors in African-American (AA) haemodialysis (HD) patients with new onset of stones during dialysis.


METHODS
Patients with nephrolithiasis (NL) newly manifested during dialysis were matched by age, sex and urine output and dialysis duration to AA HD patients without history or symptoms of stones. Two 24 h urine and serum samples were collected and analysed for conventional stone risk factors.


RESULTS
Three percent of the patients formed new stones while on HD; none had formed stones prior to end-stage renal disease. Newly onset NL patients had higher urine citrate and lower serum potassium levels than HD patients without stones.


CONCLUSIONS
Usual stone risk factors did not correlate with new stones during dialysis.
Stankus
Nicole
N
Department of Medicine, University of Chicago, Chicago, IL 60637, USA. nstankus@medicine.bsd.uchicago.edu
Worcester
Elaine
E
Hammes
Mary
M
Coe
Fredric L
FL
D001741:Black or African American; D015415:Biomarkers / Q000652:urine; D002129:Calcium Oxalate / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007669:Kidney Calculi / Q000208:ethnology / Q000209:etiology / Q000652:urine*; D007676:Kidney Failure, Chronic / Q000628:therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D015415:Biomarkers; D002129:Calcium Oxalate