Toward a total synthesis of the novel polyketide natural product spiculoic acid A.
[chemical reaction: see text]. An enantioselective approach toward the recently isolated marine natural product, spiculoic acid A, conceptualized along the proposed biogenetic hypothesis, involving an intramolecular Diels-Alder reaction as the pivotal step, is delineated. Access to a structurally embellished bicyclic core of the natural product has been accomplished.
Mehta
Goverdhan
G
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. gm@orgchem.iisc.ernet.in
Kundu
Uday Kumar
UK
D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism
D001688:Biological Products; D002264:Carboxylic Acids; D007189:Indans; C490145:spiculoic acid A