title: [Genetic linkage analysis in localizing a gene of autosomal dominant familial dilated cardiomyopathy with conduction defect].
abstract: OBJECTIVE
  To localize the gene of autosomal dominant familial dilated cardiomyopathy with conduction defect.
  
  
  METHODS
  A Chinese family which was diagnosed as dilated cardiomyopathy with conduction defect was studied. Venous blood (3 - 5 mL) from some family members was collected, and genomic DNA was extracted from the blood. Then whole genome wide scan was performed after excluding the known markers on the candidate loci (CMD1A, CMD1 E, CMD1F, and CMD1H) by two-point linkage analysis.
  
  
  RESULTS
  No significant evidence for linkage was found in the two point linkage analyses to the known markers in the analyzed family. And the whole genome wide scan showed the maximum LOD score reached 2.68 at marker D3S1614 ( at recombination fraction theta = 0).
  
  
  CONCLUSIONS
  The related gene in this kindred is located on 3q26 other than on CMD1A, CMD1H, CMD1E, and CMD1F.
authors.affiliation: National Laboratory of Medical Genetics, Central South University, Changsha, China. nlmgley@xysm.net
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Bao-Rong
authors.initials: BR
authors.lastname: Zhang
authors.forename: Zheng-Mao
authors.initials: ZM
authors.lastname: Hu
authors.forename: Qian
authors.initials: Q
authors.lastname: Pan
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Liu
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Liang
authors.forename: Ling-Qian
authors.initials: LQ
authors.lastname: Wu
authors.forename: Fang
authors.initials: F
authors.lastname: Cai
authors.forename: Zhi-Gao
authors.initials: ZG
authors.lastname: Long
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Xia
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000235:genetics*; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010375:Pedigree