Systemic administration of antibodies to glutamate increases seizure threshold for pentylenetetrazole.
We studied the effect of single intraperitoneal treatment with antibodies to glutamate on pentylenetetrazole-induced acute generalized epileptiform activity in C57Bl/6 mice. The antiepileptic effect was observed 1.5 and 24 h after administration of antibodies to glutamate in doses of 10, 25, and 50 mg/kg. This treatment increased the thresholds of clonic seizures and tonic phase of seizures with lethal outcome.
Evseev
V A
VA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Karpova
M N
MN
Vetrile
L A
LA
Klishina
N Yu
NY
Kuznetsova
L V
LV
Trekova
N A
NA
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D018698:Glutamic Acid / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control; D012710:Serum Albumin, Bovine / Q000276:immunology
D000906:Antibodies; D000927:Anticonvulsants; D012710:Serum Albumin, Bovine; D018698:Glutamic Acid; D010433:Pentylenetetrazole