title: High resolution ultrasonography in detection of bone erosions in patients with hand osteoarthritis.
abstract: OBJECTIVE
  To evaluate the ability of high resolution ultrasonography (US) in the diagnosis of erosive osteoarthritis (OA).
  
  
  METHODS
  We enrolled 110 patients with signs and symptoms of inflammatory OA. Radiographs of both hands were performed in all patients; 22 were diagnosed as having erosive OA and 88 classical OA on the basis of typical erosive/non-erosive patterns. Distal and proximal interphalangeal joints of all patients were evaluated by US by 2 independent operators blinded to patient data. The examination was performed with a multiplanar scan technique, with joints in both maximal extension and flexion, using either a 14 MHz or 8-16 MHz broadband linear probe. The presence of articular bone surface irregularities defined as either marginal osteophytes or central erosions was recorded. Sensitivity, specificity, and likelihood ratios on the presence of erosions were calculated.
  
  
  RESULTS
  Central erosions were detected by US in 16 of 22 (72.7%) patients with erosive OA and in none of 88 patients with classical hand OA. Sensitivity and specificity for the detection of central erosions by US were 73% and 100%, respectively. The positive and negative likelihood ratios were 100% and 94%.
  
  
  CONCLUSIONS
  This is the first study to evaluate the presence of erosions in patients with erosive OA by US. Our results showed good concordance between US and radiography in detecting central joint erosions. We believe US may be considered a useful technique for the differential diagnosis between erosive OA and classical hand OA.
authors.affiliation: Cattedra di Reumatologia, Dipartimento di Clinica e Terapia Medica Applicata, Università di Roma La Sapienza, Rome, Italy. annamaria.iagnocco@uniroma1.it
authors.forename: Annamaria
authors.initials: A
authors.lastname: Iagnocco
authors.forename: Emilio
authors.initials: E
authors.lastname: Filippucci
authors.forename: Alejandra
authors.initials: A
authors.lastname: Ossandon
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ciapetti
authors.forename: Fausto
authors.initials: F
authors.lastname: Salaffi
authors.forename: Stefania
authors.initials: S
authors.lastname: Basili
authors.forename: Walter
authors.initials: W
authors.lastname: Grassi
authors.forename: Guido
authors.initials: G
authors.lastname: Valesini
mesh_terms: D000368:Aged; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging*; D006801:Humans; D016013:Likelihood Functions; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014463:Ultrasonography / Q000379:methods / Q000592:standards