[Effect of correction of tetrachlormethane hepatosis by complete fasting].
Processes of free radical lipid oxidation (FLI), endogenic intoxication, antioxidant protection system (AOP) and morphology of a liver at tetrachlormethane hepatosis and its correction by a complete fasting have been assessed. Two chains of pathogenesis of tetrachlormethane hepatosis have been determined: the metabolic chain that is accompanied by sharp activation of free radical lipid oxidation under emaciation of antioxidant protection system and increasing endotoxemia; and the ischemic chain that enhances the processes of dystrophy and necrosis of hepatocytes and neofibrous formations. The correction by a complete fasting promoted normalization of free radical lipid oxidation at simultaneous rising of antioxidant protection system function, decreasing of a level of endogenic intoxication and conservation of hepatocytes' structure, improving recovering possibilities and prevents dystrophic and necrotic changes and neofibrous formations in the liver at tetrachlormethane hepatosis.
Kuziv
O Ie
OIe
Bodnar
Ia Ia
IaIa
Kuziv
P P
PP
Klymchuk
L F
LF
Zavads'ka
T S
TS
Derpak
Iu Iu
IuIu
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism* / Q000473:pathology; D005215:Fasting; D005609:Free Radicals; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis / Q000473:pathology; D010084:Oxidation-Reduction; D051381:Rats
D005609:Free Radicals