title: Birth outcome in women with breast cancer.
abstract: We investigated whether maternal breast cancer affects birth outcome in a nationwide cohort study of 695 births from 1973 to 2002 of women with breast cancer with respect to preterm birth, low birth weight at term, stillbirth and congenital abnormalities as well as mean birth weight, compared with the outcomes of 33 443 births from unaffected mothers. There was no excess risk of adverse birth outcome for the 216 newborns of women with breast cancer before pregnancy. Stratification by mother's treatment did not change the results. For 37 newborns of women diagnosed during pregnancy, the prevalence ratio (PR) of preterm birth was 8.1 (95% confidence interval (CI): 3.8-17). However, 10 of the 12 preterm deliveries among these women were elective early deliveries. Among 442 births of women diagnosed in the 2 years from time of delivery, the PR of preterm birth was 1.4 (95% CI: 1.0-2.0), and the PR of low birth weight at term for boys was 2.9 (95% CI: 1.3-6.3). Overall, our results are reassuring regarding the risks of adverse birth outcome for breast cancer patients.
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Ole Worms Allé 150, DK-8000, Aarhus C, Denmark. vl@dce.au.dk
authors.forename: V
authors.initials: V
authors.lastname: Langagergaard
authors.forename: M
authors.initials: M
authors.lastname: Gislum
authors.forename: M V
authors.initials: MV
authors.lastname: Skriver
authors.forename: B
authors.initials: B
authors.lastname: Nørgård
authors.forename: T L
authors.initials: TL
authors.lastname: Lash
authors.forename: K J
authors.initials: KJ
authors.lastname: Rothman
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000150:complications*; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth; D015995:Prevalence; D012307:Risk Factors