title: The use of autologous chondrocyte implantation following and combined with anterior cruciate ligament reconstruction.
abstract: We report our experience of using autologous chondrocyte implantation (ACI) to treat osteochondral defects of the knee in combination with anterior cruciate ligament (ACL) reconstruction. The outcome of symptomatic osteochondral lesions treated with ACI following previous successful ACL reconstruction is also reviewed. Patients were followed for a mean of 23 months. Nine patients underwent ACL reconstruction in combination with ACI. Mean modified Cincinnati knee scores improved from 42 to 69 following surgery. Seven patients described their knee as better and two as the same. A second group of nine patients underwent ACI for symptomatic articular cartilage defects following previous ACL reconstruction. In this group, the mean modified Cincinnati knee score improved from 53 to 62 after surgery. Six patients described their knee as better and three as worse. Combined treatment using ACI with ACL reconstruction is technically feasible and resulted in sustained improvement in pain and function. The results following previous ACL reconstruction also resulted in clinical improvement, although results were not as good as following the combined procedure.
authors.affiliation: Joint Reconstruction and Bone Tumour Unit, Royal National Orthopaedic Hospital, Brockley Hill, HA7 4LP Stanmore, UK. amitamin@doctors.org.uk
authors.forename: A A
authors.initials: AA
authors.lastname: Amin
authors.forename: W
authors.initials: W
authors.lastname: Bartlett
authors.forename: C R
authors.initials: CR
authors.lastname: Gooding
authors.forename: M
authors.initials: M
authors.lastname: Sood
authors.forename: J A
authors.initials: JA
authors.lastname: Skinner
authors.forename: R W J
authors.initials: RW
authors.lastname: Carrington
authors.forename: T W R
authors.initials: TW
authors.lastname: Briggs
authors.forename: G
authors.initials: G
authors.lastname: Bentley
mesh_terms: D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous