title: New fatty acid derivatives from Homaxinella sp., a marine sponge.
abstract: Fractionation of the MeOH extract of Homaxinella sp., a marine sponge, led to the isolation of a sodium salt of a new brominated FA (1), two new MG (2 and 4), and a new lysoPC (6). The geometry of the double bonds in 1 and 2 was defined by comparison of the NMR chemical shifts of the allylic carbons, nuclear Overhauser effect spectroscopy correlations of the allylic protons, and coupling constants of the vinylic protons with those reported. Evidence mainly from NMR and MS analyses established the planar structures of the compounds. Compounds 1, 2, 4, and 6 were evaluated for cytotoxicity against a panel of five human solid tumor cell lines. Only compound 1 showed moderate activity.
authors.affiliation: College of Pharmacy, Pusan National University, Busan, Korea.
authors.forename: Tayyab A
authors.initials: TA
authors.lastname: Mansoor
authors.forename: Bok Hee
authors.initials: BH
authors.lastname: Bae
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong O
authors.initials: CO
authors.lastname: Lee
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001966:Bromine / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008244:Lysophosphatidylcholines / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D050178:Monoglycerides / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005227:Fatty Acids; D008244:Lysophosphatidylcholines; D050178:Monoglycerides; C508273:homaxicholine A; C508271:homaxinolin A; C508272:homaxinolin B; D001966:Bromine