title: [Evaluation of host immunity and side effects in breast cancer patients treated with adjuvant chemotherapy (FEC therapy)].
abstract: BACKGROUND
  FEC (5-FU+epirubicin+cyclophosphamide) therapy has been used as adjuvant chemotherapy for breast cancer patients with nodes positive. The aim of this study was to evaluate host immunity and side effects of the FEC therapy. The effect of oral administration of Lentinus edodes mycelia (LEM) was also observed.
  
  
  METHODS
  Ten patients were enrolled in this study. The treatment with 5-FU (500 mg/m2), epirubicin (75 mg/m2) and cyclophosphamide (500 mg/m2) was administered every 21 days for 2 cycles, and LEM (9 g/day po) was administered during the 2nd cycle.
  
  
  RESULTS
  NK cell activity and the number of white blood cells decreased on the 7th day after the therapy, and they recovered on the 21st day. However, this NK cell activity and the number of white blood cells didn't decrease when the FEC therapy was used with LEM po.
  
  
  CONCLUSIONS
  FEC 75 therapy has made some impacts on host immunity, and LEM with the FEC 75 therapy might have prevented host immunity.
authors.affiliation: Dept. of Surgery II, Yamaguchi University School of Medicine.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Noriko
authors.initials: N
authors.lastname: Sanpei
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Shigehumi
authors.initials: S
authors.lastname: Yoshino
authors.forename: Akira
authors.initials: A
authors.lastname: Tangoku
authors.forename: Masaaki
authors.initials: M
authors.lastname: Oka
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000276:immunology*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects; D015251:Epirubicin / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D005656:Fungal Proteins / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D011134:Polysaccharides / Q000008:administration & dosage
chemical_list: D005656:Fungal Proteins; C061242:Lentinus edodes mycelia extract E-P-LEM; D011134:Polysaccharides; D015251:Epirubicin; D003520:Cyclophosphamide; D005472:Fluorouracil