title: Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.
abstract: The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.
authors.affiliation: Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.
authors.forename: Omar E
authors.initials: OE
authors.lastname: Christian
authors.forename: Jennifer
authors.initials: J
authors.lastname: Compton
authors.forename: Keisha R
authors.initials: KR
authors.lastname: Christian
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mooberry
authors.forename: Fredrick A
authors.initials: FA
authors.lastname: Valeriote
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D047630:Depsipeptides / Q000494:pharmacology*; D026121:Indole Alkaloids; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera
chemical_list: D047630:Depsipeptides; D026121:Indole Alkaloids; D007211:Indoles; C057531:jasplakinolide; C019290:chaetoglobosins