Timentin (ticarcillin/clavulanic acid): lack of antagonism in an in vitro kinetic model, against bacteria producing inducible class-1 beta-lactamase.
Slocombe
B
B
Beecham Pharmaceuticals Research Division, Brockham Park, Betchworth. Surrey, England.
Cooper
C E
CE
Masters
P J
PJ
Warrack
J D
JD
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002969:Clavulanic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology*; D004790:Enzyme Induction; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology*; D013982:Ticarcillin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004791:Enzyme Inhibitors; C043215:ticarcillin-clavulanic acid; C054882:beta-lactamase PIT-2; D001618:beta-Lactamases; D013982:Ticarcillin