title: Methodology of mapping quantitative trait loci for ordinal traits of disease resistance in livestock.
abstract: Methodology of QTL mapping for ordinal traits of disease resistance based on the framework of a generalized linear model (GLM) was presented. The location and effect parameters of putative QTL were estimated using maximum likelihood method. The efficiency and power were compared with the linear model (LM). The factors influencing QTL detection efficiency (e.g. QTL effect and heritability) were simulated in our study too. Daughter design with multiple families was applied,and the number of segregating population was 500. Results showed that the threshold model has a certain advantage in location estimation and power of QTL mapping, and has efficiency and accuracy for ordinal traits. In addition,the accuracy of QTL mapping depends on the effect of putative quantitative trait loci and the value of heritability. With the increase of QTL effect and heritability, the accuracy of QTL mapping improves slightly.
authors.affiliation: Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100094, China. yinzongjun@yahoo.com.cn
authors.forename: Zong-Jun
authors.initials: ZJ
authors.lastname: Yin
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Zhang
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Ding
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000235:genetics*; D007113:Immunity, Innate / Q000235:genetics*; D008957:Models, Genetic; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable