title: Recent insights into the mechanisms of Chlamydia entry.
abstract: Chlamydia are widespread bacteria that grow in human and animal cells. They enter their host cell, establish an intracellular environment favourable for their multiplication and finally exit the host cell. A combination of host cell factors and of bacterial proteins contribute to pathogen entry. Recent advances have shed new light on the entry mechanism, following attachment. Here we review recent data concerning endocytosis, host cell signalling, proteins secreted by the bacteria, the actin cytoskeleton in entry and the involvement of small GTPases.
authors.affiliation: Unité de Biologie des Interactions Cellulaires, Institut Pasteur, URA CNRS 2582, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. adautry@pasteur.fr
authors.forename: Alice
authors.initials: A
authors.lastname: Dautry-Varsat
authors.forename: Agathe
authors.initials: A
authors.lastname: Subtil
authors.forename: Ted
authors.initials: T
authors.lastname: Hackstadt
mesh_terms: D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D000818:Animals; D002689:Chlamydia / Q000472:pathogenicity / Q000502:physiology*; D002690:Chlamydia Infections / Q000382:microbiology*; D003599:Cytoskeleton / Q000378:metabolism; D004705:Endocytosis; D004847:Epithelial Cells / Q000382:microbiology / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism; D015398:Signal Transduction; D037521:Virulence Factors
chemical_list: D000089982:ADP-Ribosylation Factor 6; D000199:Actins; D037521:Virulence Factors; D020558:GTP Phosphohydrolases; D020727:ADP-Ribosylation Factors