title: Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.
abstract: [chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.
authors.affiliation: Broad Institute of Harvard and MIT, Chemical Biology Program, Cambridge, Massachusetts 02141, USA.
authors.forename: Sameer
authors.initials: S
authors.lastname: Urgaonkar
authors.forename: Henry S
authors.initials: HS
authors.lastname: La Pierre
authors.forename: Israel
authors.initials: I
authors.lastname: Meir
authors.forename: Henrik
authors.initials: H
authors.lastname: Lund
authors.forename: Debabrata
authors.initials: D
authors.lastname: RayChaudhuri
authors.forename: Jared T
authors.initials: JT
authors.lastname: Shaw
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001426:Bacterial Proteins / Q000187:drug effects* / Q000502:physiology; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002712:Chlorides; D048749:Cytokinesis / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000187:drug effects* / Q000502:physiology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D044950:Flavanones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020558:GTP Phosphohydrolases / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D017967:Zinc Compounds
chemical_list: C512548:2'''-hydroxy-5''-benzylisouvarinol-B; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001688:Biological Products; D002712:Chlorides; D003598:Cytoskeletal Proteins; D004791:Enzyme Inhibitors; D044950:Flavanones; C071525:FtsZ protein, Bacteria; D017967:Zinc Compounds; C512547:dichamanetin; C016837:zinc chloride; D020558:GTP Phosphohydrolases