title: Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide.
abstract: Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.
authors.affiliation: Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.
authors.forename: Seong L
authors.initials: SL
authors.lastname: Khaw
authors.forename: Peter A
authors.initials: PA
authors.lastname: Downie
authors.forename: Keith D
authors.initials: KD
authors.lastname: Waters
authors.forename: David M
authors.initials: DM
authors.lastname: Ashley
authors.forename: John A
authors.initials: JA
authors.lastname: Heath
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy; D015080:Mesna / Q000008:administration & dosage / Q000009:adverse effects*; D012516:Osteosarcoma / Q000188:drug therapy; D020011:Protective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D013125:Spinal Neoplasms / Q000188:drug therapy
chemical_list: D020011:Protective Agents; D003520:Cyclophosphamide; D015080:Mesna