Augmented oxidative stress as well as antioxidant capacity in maternal circulation in preeclampsia.
OBJECTIVE
Isoprostanes are stable markers of oxidative stress. We wanted to assess maternal circulating levels of total 8-isoprostane and indices of antioxidant capacity in preeclampsia compared to uneventful pregnancies.


METHODS
Total 8-isoprostane concentrations, FRAP (ferric reducing ability of plasma), Vitamin E and d-ROM (diacron reactive oxygen metabolites) were measured in maternal venous blood samples from preeclamptic (n=21) and uncomplicated (n=38) pregnancies at cesarean section.


RESULTS
Median total 8-isoprostane concentration was elevated in preeclampsia compared to uncomplicated pregnancies (354 and 218 pg/mL, P=0.02). Median FRAP level was also elevated in preeclampsia compared to uncomplicated pregnancies, but to a lesser degree than 8-isoprostane. A positive correlation between 8-isoprostane and previously analyzed placenta-derived sFlt1 (soluble fms-like tyrosine kinase 1) levels in the maternal circulation was found in preeclampsia.


CONCLUSIONS
We found a relative more increase for the oxidative stress marker (8-isoprostane) than for the antioxidant capacity (FRAP) in preeclampsia compared to uneventful pregnancies.
Harsem
Nina K
NK
Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway. ninakittelsen.harsem@ulleval.no
Braekke
Kristin
K
Staff
Anne Cathrine
AC
D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000502:physiology*; D002585:Cesarean Section; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy
D000975:Antioxidants; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost