Ischemia-reperfusion injury--antiarrhythmic effect of melatonin associated with reduced recovering of contractility.
The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart. 25 min global ischemia was induced and followed by 30 min of reperfusion. Melatonin (10 micromol/l) was present in the perfusion solution during the whole experiment. Experiment revealed protective effect of melatonin on reperfusion-induced arrhythmias--arrhythmia score was significantly lower as well as the total time of arrhythmias duration was significantly shorter in melatonin group than in controls. On the other hand, post-ischemic recovering of contractility was significantly reduced in melatonin group.
Vazan
R
R
Department of Physiology, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava 1, Slovakia. rastislav.vazan@fmed.uniba.sk
Pancza
D
D
Béder
I
I
Styk
J
J
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000473:pathology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007511:Ischemia / Q000473:pathology; D008297:Male; D008550:Melatonin / Q000378:metabolism* / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D016011:Normal Distribution; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D016166:Free Radical Scavengers; D008550:Melatonin