[Effects of drugs on the adrenal cortex and its tumors].
The structure of the normal adrenal cortex is changed by stimulating hormones (ACTH) and inhibiting hormonal drugs (especially glucocorticoids). ACTH induces hyperplasia and lipid depletion in the fascicular and reticular zones, whereas glucocorticoids lead to atrophy and lipid accumulation in both zones. In animal experiments, the adrenostatic drug mitotane causes shrinkage of the cells of the fascicular and reticular zones, whereas metyrapone induces a decrease in the steroid producing organelle system and aminoglutethimide leads to an increase in lipids. In the therapy of patients with adrenocortical cancer, mitotane can cause an increase in of necrosis and fibrosis, but also in intracellular lipid. The ultrastructure shows increased liposomes, more pigment-rich lysosomes and laminated bodies.
Saeger
W
W
Institut für Pathologie des Marienkrankenhauses Hamburg, Alfredstrasse 9, 22087 Hamburg. saeger.patho@marienkrankenhaus.org
Fassnacht
M
M
D000302:Adrenal Cortex / Q000187:drug effects / Q000473:pathology*; D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000616:Aminoglutethimide / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D015388:Organelles / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D000616:Aminoglutethimide; D000324:Adrenocorticotropic Hormone