title: Two new triterpenes from the husks of Xanthoceras sorbifolia.
abstract: Two new triterpenes, 22-angeloyl-21-epoxyangeloylbarringtogenol C (1) and 21,22-diangeloyl-24-hydroxy-R(1)-barrigenol (2), and the known 21,22-diangeloyl-R(1)-barrigenol (3) were isolated from the husks of Xanthoceras sorbifolia Bunge. Their structures were elucidated based on detailed NMR analysis. Compounds 1 and 2 inhibited significantly the growth of cancer cell lines (A375-S2, HeLa) with IC(50) values ranging from 2.9 to 76.3 micromol/L.
authors.affiliation: Research Department of Natural Medicines, Shenyang Pharmaceutical University, Shenyang, PR China.
authors.forename: Zhan-Lin
authors.initials: ZL
authors.lastname: Li
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Lin-Hao
authors.initials: LH
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Yu
authors.forename: Da-Li
authors.initials: DL
authors.lastname: Meng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D029631:Sapindaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C507333:21,22-diangeloyl-24-hydroxy-R(1)-barrigenol R; C507345:21,22-diangeloyl-R(1)-barrigenol; C507334:22-angeloyl-21-epoxyangeloylbarringtogenol C; D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes