From the experimental laboratory to the patient: how does it happen?
Many potential therapeutic agents or drugs are evaluated in experimental animal laboratories, but in spite of interesting effects, they infrequently come into common clinical use. The reasons for this are reviewed. Agents studied previously and many being studied now are cited. Perhaps the biggest benefit of study of drugs in animals (other than for safety and toxicity) is to help us better understand the pathophysiology of disease.
Baue
Arthur E
AE
Box 396, Fisher's Island, New York 06390, USA.
D000818:Animals; D000830:Animals, Laboratory; D035843:Biomedical Research; D003226:Congresses as Topic; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D012769:Shock / Q000188:drug therapy* / Q000378:metabolism; D012955:Societies, Medical; D018675:Toxicity Tests