[Differential display of homeobox gene expressions in the normal, wounded human fetal and adult skins by DNA microarray].
OBJECTIVE
To explore the differential expression of homeobox genes in the normal, wounded human fetal and adult skins and its significance in fetal scarless healing.


METHODS
Gene chips containing 14 000 human genes were used to investigate homeobox gene expressions of the normal, wounded human fetal and adult skins.


RESULTS
There were significant differences between the expression of homeobox genes, especially for PRX-2, HOXB13, HOXB6 and HOXB7.


CONCLUSIONS
The homeobox gene is in close relation to developmental biology. The different expressions and changes of homeobox genes in the normal, wounded human fetal and adult skin may be a primary cause of different wound healing between fetal and adult skin.
Song
Hui-Feng
HF
Department of Burns and Plastic Surgery, Burn Institute, the 304th Hospital Affiliated to PLA General Hospital, Beijing 100037, China.
Chai
Jia-Ke
JK
Chen
Min-Liang
ML
Lin
Zi-Hao
ZH
D000293:Adolescent; D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D002648:Child; D005260:Female; D005333:Fetus; D015870:Gene Expression; D020869:Gene Expression Profiling; D005801:Genes, Homeobox / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020411:Oligonucleotide Array Sequence Analysis; D012867:Skin; D014945:Wound Healing / Q000235:genetics*; D055815:Young Adult
D018398:Homeodomain Proteins