[Soothing effect of Ganoderma lucidum antlered form on cyclophosphamide-induced adverse reaction].
The immunological functions of Ganoderma lucidum antlered form (AF) (Rokkaku-Reishi in Japanese), a variant type of Ganoderma lucidum, were investigated in C57BL/6 mice treated with cyclophosphamide (CY). Ganoderma lucidum AF alleviated CY-induced decrease in body weight and abnormal increase in blood neutrophil level, when the mice were fed a diet containing 2.5% Ganoderma lucidum AF starting one week before CY treatment (150 mg/kg, ip). The recovery of CD8+ and NK1.1+ cells in the spleen was accelerated in Ganoderma lucidum AF group compared to the control group. Ganoderma lucidum AF also both alleviated CY-induced splenic lymphopenia and suppressed the abnormal increase in splenocytes 7 days after CY treatment. These results suggest that ingestion of Ganoderma lucidum AF is beneficial for improvement of quality of life reduced by anti-cancer chemotherapeutic drugs such as CY.
Nonaka
Yuji
Y
Institute for Health Care Science, Suntory Ltd.
Ishibashi
Hiroko
H
Nakai
Masaaki
M
Shibata
Hiroshi
H
Kiso
Yoshinobu
Y
Abe
Shigeru
S
D000284:Administration, Oral; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils; D020940:Reishi
D018906:Antineoplastic Agents, Alkylating; D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide