Validation of the clinical approach of using the induced serum iron increase after 1h as a measure of iron absorption.
OBJECTIVE
To evaluate the correlation between the iron absorption and the induced increase in serum iron concentration (S-Fe) after 1 h.


METHODS
Eleven subjects were after an over night fast served a wheat roll fortified with 100-mg iron as ferrous sulfate labelled with radio iron. The S-Fe response and the iron absorption measured by whole body counting, were studied.


RESULTS
There was a significant correlation between the iron absorption and the S-Fe increase (R2 = 0.75, P < 0.001).


CONCLUSIONS
This short and valid observation period proposes the S-Fe procedure as an uncomplicated and clinically applicable tool when evaluating the iron absorption capacity of patients.
Hoppe
Michael
M
Department of Clinical Nutrition, Institute of Internal Medicine, Sahlgrenska Academy at Göteborg University, S-405 30 Göteborg, Sweden. michael.hoppe@nutrition.gu.se
Hulthén
Lena
L
D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D001782:Blood Donors; D005527:Food, Fortified; D006801:Humans; D007408:Intestinal Absorption; D019266:Iron, Dietary / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male
D019266:Iron, Dietary