[A case of intraperitoneal paclitaxel administration in a gastric cancer patient with severely impaired renal function].
This study was designed to evaluate the pharmacokinetics and toxicity of paclitaxel, administered via an intraperitoneal route for a gastric cancer patient with renal dysfunction. The patient was a woman in her 50's, who had been diagnosed with severe renal dysfunction but no treatment history was known. She complained of dyspnea for a large quantity of ascites and was urgently hospitalized. It was diagnosed as gastric cancer with peritoneal dissemination. At this hospital, PTX was administered weekly intraperitoneally through an infusion port without complication. This result suggested that intraperitoneal PTX chemotherapy for a patient with renal dysfunction was a safe treatment.
Ohbu
Masahide
M
Dept of Surgery, Tokyo Metropolitan Toshima Hospital.
Maruyama
Michio
M
Miyawaki
Yutaka
Y
Tamura
Nobuko
N
Koide
Ayaki
A
Hasegawa
Kumi
K
Maruyama
Shouji
S
Takashima
Itaru
I
Ebuchi
Masakazu
M
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D001201:Ascites / Q000150:complications; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007674:Kidney Diseases / Q000150:complications*; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel