The use of tamoxifen to improve height potential in short pubertal boys.
A retrospective chart review of 7 pubertal boys who were treated with tamoxifen was conducted to determine the effects of this therapy on skeletal maturation and predicted adult height. Tamoxifen significantly decreased the rate of skeletal maturation and increased the predicted adult height without negative effects on sexual maturation. Additional evaluation of this therapy is now required to determine if the increase in predicted adult height results in a clinically significant increase in final adult height.
Kreher
Nerissa C
NC
Section of Pediatric Endocrinology and Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA. nkreher@iupui.edu
Eugster
Erica A
EA
Shankar
R Ravi
RR
D000293:Adolescent; D001827:Body Height; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D006130:Growth Disorders / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011627:Puberty; D012189:Retrospective Studies; D013629:Tamoxifen / Q000627:therapeutic use*
D050071:Bone Density Conservation Agents; D013629:Tamoxifen