title: Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
abstract: The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.
authors.affiliation: Department of Medicinal Chemistry, AstraZeneca R&D Södertälje, S-151 85, Södertälje, Sweden. britt-marie.swahn@astrazeneca.com
authors.forename: Britt-Marie
authors.initials: BM
authors.lastname: Swahn
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Xue
authors.forename: Erwan
authors.initials: E
authors.lastname: Arzel
authors.forename: Elisabet
authors.initials: E
authors.lastname: Kallin
authors.forename: Angelika
authors.initials: A
authors.lastname: Magnus
authors.forename: Niklas
authors.initials: N
authors.lastname: Plobeck
authors.forename: Jenny
authors.initials: J
authors.lastname: Viklund
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D018360:Crystallography, X-Ray; D015195:Drug Design; D020128:Inhibitory Concentration 50; D048057:Mitogen-Activated Protein Kinase 10 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000814:Aniline Compounds; D011725:Pyridines; D048057:Mitogen-Activated Protein Kinase 10; C023650:aniline