title: Diagnosis of insulin resistance and associated syndromes: the spectrum from the metabolic syndrome to type 2 diabetes mellitus.
abstract: Insulin resistance is a common underlying physiologic abnormality associated with central obesity, type 2 diabetes and cardiovascular disease. Clinically, its hallmark markers of hypertension, glucose intolerance and dyslipidemia have been grouped into associated syndromes of insulin resistance. Insulin resistance is now considered a useful marker of clinical risk and a target for therapeutic intervention. While the criteria for diagnosis of syndromes related to insulin resistance have been established, the clinical diagnosis of insulin resistance remains a significant challenge. As more clinicians focus on the management of insulin resistance in patients with cardiovascular disease, type 2 diabetes and other syndromes of insulin resistance, its diagnosis will take on increasing importance. This review focuses on the current definition and diagnosis of insulin resistance and associated syndromes.
authors.affiliation: International Diabetes Center, Park Nicollet, Minneapolis, Minnesota 55416-2699, USA. Gregg.simonson@ParkNicollet.com
authors.forename: Gregg D
authors.initials: GD
authors.lastname: Simonson
authors.forename: David M
authors.initials: DM
authors.lastname: Kendall
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D007328:Insulin