title: Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women.
abstract: We investigated whether circulating insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels are associated with the risk of fibrocystic breast conditions (FBC), in a case-control study nested within a randomized trial of breast self-examination conducted in Shanghai, China. Participants were enrolled during 1989-1991 and were followed over 10 years for the development of breast diseases. Controls (n = 897) were frequency-matched by age to cases (n = 451), who were diagnosed with FBC between 1995 and 2000. Circulating IGF-I and IGFBP-3 levels and their molar ratio were positively associated with risk of FBC. The odds ratios (ORs) and 95% confidence intervals (CI) for the upper fourth of the distribution compared to the lowest fourth for IGF-I, IGFBP3 and their molar ratio were 3.02 (2.02-4.52), 1.92 (1.37-2.71) and 2.26 (1.52-3.36), respectively. The strength of the association between IGF-I levels and FBC was attenuated after adjustment for IGFBP-3 and that for IGFBP-3 was largely eliminated after adjustment for IGF-I. Increasing levels of IGF-I were particularly associated with increasing risk of FBC with proliferative elements (ORs and 95% CIs for the 2nd, 3rd and upper fourth of the distribution of IGF-I: 3.13 (1.50-6.53), 4.57 (2.22-9.39) and 6.30 (3.08-12.89), compared with the lowest fourth. Our results suggest that elevated levels of IGF-I may contribute to the development of FBC.
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. cchen@fhcrc.org
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Doherty
authors.forename: S Kay
authors.initials: SK
authors.lastname: Lewis
authors.forename: Roberta M
authors.initials: RM
authors.lastname: Ray
authors.forename: Dao Li
authors.initials: DL
authors.lastname: Gao
authors.forename: Helge
authors.initials: H
authors.lastname: Stalsberg
authors.forename: Ziding
authors.initials: Z
authors.lastname: Feng
authors.forename: David B
authors.initials: DB
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D049109:Cell Proliferation; D002681:China; D005260:Female; D005348:Fibrocystic Breast Disease / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I