How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?
Endothelin and reactive oxygen species have been identified as important mediators in the pathogenesis of hypertension and associated end-organ damage. In the present issue of Clinical Science, Callera and co-workers have provided new evidence that endothelin stimulates mitochondria to generate reactive oxygen species in the vascular wall during mineralocorticoid-induced hypertension in the rat. These studies open a new line of investigation that could be important for the development of therapeutic strategies; however, there still remains a great deal of uncertainty about the mechanisms that define the relationship between endothelin and oxidative stress in hypertension.
Pollock
David M
DM
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA. dpollock@mcg.edu
D000818:Animals; D016232:Endothelins / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D008901:Mineralocorticoids; D023421:Models, Animal; D018384:Oxidative Stress; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*
D016232:Endothelins; D008901:Mineralocorticoids; D017382:Reactive Oxygen Species