title: Successful treatment of a patient with chronic lymphocytic leukaemia (CLL) presenting with bony metastases with aggressive antibody and chemotherapy.
abstract: Osteolytic lesions are rare in chronic lymphocytic leukaemia (CLL) and thought to result from Richter's transformation or metastatic disease from nonlymphoid malignancies. We report a patient who presented with a large femoral metastatic lesion and hypercalcaemia caused by CLL itself. Complete remission of CLL with resolution of the osteolytic lesion was achieved with rituximab and cyclophosphamide, adriamycin, oncovin and prednisolone [CHOP (R-CHOP)] combination chemotherapy.
authors.affiliation: Department of Haematology, Warwick Hospital, Warwick, UK.
authors.forename: H
authors.initials: H
authors.lastname: Narayan
authors.forename: D
authors.initials: D
authors.lastname: Bandyopadhyay
authors.forename: K
authors.initials: K
authors.lastname: Schmidt
authors.forename: N
authors.initials: N
authors.lastname: Chachlani
authors.forename: M
authors.initials: M
authors.lastname: Hughes
authors.forename: S
authors.initials: S
authors.lastname: Paneesha
authors.forename: P
authors.initials: P
authors.lastname: Rose
authors.forename: A
authors.initials: A
authors.lastname: Borg
mesh_terms: D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005269:Femur; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction / Q000379:methods; D000069283:Rituximab; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone