title: Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis.
abstract: Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 microg ml(-1), which was higher than the usual therapeutic concentration (1-5 microg ml(-1)), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.
authors.affiliation: Craniomaxillofacial Reconstructive Science Major, Dental Research Institute, College of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, 110-749, Seoul, Korea.
authors.forename: Yoon Jeong
authors.initials: YJ
authors.lastname: Park
authors.forename: Jue Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Hey Ri
authors.initials: HR
authors.lastname: Yeom
authors.forename: Kyung Hwa
authors.initials: KH
authors.lastname: Kim
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Lee
authors.forename: In Kyoung
authors.initials: IK
authors.lastname: Shim
authors.forename: Chong Pyoung
authors.initials: CP
authors.lastname: Chung
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D020341:Absorbable Implants; D002214:Capsules / Q000008:administration & dosage / Q000737:chemistry; D004058:Diffusion; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D007267:Injections; D008911:Minocycline / Q000008:administration & dosage* / Q000737:chemistry*; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D011134:Polysaccharides / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D002214:Capsules; D004343:Drug Implants; D011134:Polysaccharides; D008911:Minocycline