Changes of parvalbumin immunoreactive neurons and GFAP immunoreactive astrocytes in the rat lateral geniculate nucleus following monocular enucleation.
The expression of calcium binding proteins (CaBPs) has been linked to protection of neurons. The present study investigated the effects of monocular enucleation on the distribution of parvalbumin immunoreactive (PV-IR) neurons and glial fibrillary acidic protein immunoreactive (GFAP-IR) astrocytes in both the dorsal (dLGN) and ventral (vLGN) regions of the lateral geniculate nucleus (LGN). Our results demonstrated an increase in PV-IR neuronal density on the contralateral vLGN at 1-week post-enucleation (PE), which was maintained without significant change for 12 weeks. By contrast, PV-IR neurons in dLGN decreased significantly at all time point examined. The number of GFAP-IR astrocytes showed an initial increase from 1 to 4 weeks PE and then gradually decreased until 48 weeks in both regions of the LGN with contralateral side predominance. The present results suggest that monocular enucleation results in variable expression of PV-IR neurons and GFAP-IR astrocytes in the LGN complex, which may play an important role in neuronal degeneration and neuroplasticity of the rat visual system.
Gonzalez
Daniel
D
Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan.
Satriotomo
Irawan
I
Miki
Takanori
T
Lee
Kyong-Youl
KY
Yokoyama
Toshifumi
T
Touge
Tetsuo
T
Matsumoto
Yoshiki
Y
Li
Hong-Peng
HP
Kuriyama
Shigeki
S
Takeuchi
Yoshiki
Y
D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D005123:Eye / Q000294:innervation*; D015353:Eye Enucleation; D005829:Geniculate Bodies / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005904:Glial Fibrillary Acidic Protein; D010320:Parvalbumins