Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes.
A novel unusual 17-carbon diterpenoid, named (+)-7-deoxynimbidiol, was isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Its racemate and derivatives were synthesized, and the inhibitory activities of these compounds against four cultured human-tumor cell lines were evaluated. The structure-activity relationship was discussed.
Xiong
Yi
Y
Department of Chemistry, Zhejiang University 310027, PR China.
Wang
Kuiwu
K
Pan
Yuanjiang
Y
Sun
Hongxiang
H
Tu
Jue
J
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D031247:Celastrus / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C509736:7-deoxynimbidiol; D000970:Antineoplastic Agents; D004224:Diterpenes