Effect of human neural progenitor cells on injured spinal cord.
OBJECTIVE
To study whether human neural progenitor cells can differentiate into neural cells in vivo and improve the recovery of injured spinal cord in rats.


METHODS
Human neural progenitor cells were transplanted into the injured spinal cord and the functional recovery of the rats with spinal cord contusion injury was evaluated with Basso-Beattie-Bresnahan (BBB) locomotor scale and motor evoked potentials. Additionally, the differentiation of human neural progenitor cells was shown by immunocytochemistry.


RESULTS
Human neural progenitor cells developed into functional cells in the injured spinal cord and improved the recovery of injured spinal cord in both locomotor scores and electrophysiological parameters in rats.


CONCLUSIONS
Human neural progenitor cells can treat injured spinal cord, which may provide a new cell source for research of clinical application.
Xu
Guang-Hui
GH
Department of Orthopedics, Zibo Central Hospital, Zibo City 255036, Shandong Province , China.
Bai
Jin-Zhu
JZ
Cai
Qin-Lin
QL
Li
Xiao-Xia
XX
Li
Ling-Song And Shen Li
LS
Shen
Li
L