title: [A case of unresectable cholangiocellular carcinoma treated with surgery followed by combination chemotherapy].
abstract: The patient was a 44-year-old man, who was investigated for lateral abdominal pain and liver dysfunction, and subsequently referred to our department with a diagnosis of unresectable intrahepatic cholangiocellular carcinoma (CCC). Radiological examinations revealed the huge mass in the right lobe of the liver with intrahepatic metastasis in the left lobe. The main tumor was surgically removed, but the metastases were not removed. A month after the operation, a subcutaneous implant reservoir was indwelled for repeated transcatheter hepatic arterial chemo infusion therapy (5-fluorouracil 500 mg/day continuous infusion, day 1-5, and CDDP 10 mg/day, day 1) from the right femoral artery. After 15 courses of home anti-cancer chemotherapy, abdominal CT revealed that the size of intrahepatic metastasis in the left lobe of the liver had not shown growth, whereas other metastitic sites popped up in the caudate lobe, which were free of chemical agent flow. There was no major complication related to the chemotherapy throughout the post-treatment course. Although he maintained a good level of QOL, he refused further chemotherapy due to depression. He died of liver failure 7 months after the operation. In conclusion, volume reduction surgery followed by transcatheter hepatic arterial chemo infusion might be promising as an effective therapy for non resectable CCC.
authors.affiliation: Dept. of Surgery, Hyogo Prefectural Nishinomia Hospital.
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Hayashi
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Nariaki
authors.initials: N
authors.lastname: Fukuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kida
authors.forename: Masaki
authors.initials: M
authors.lastname: Tujie
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yoshida
authors.forename: Chikara
authors.initials: C
authors.lastname: Ebisui
authors.forename: Isao
authors.initials: I
authors.lastname: Sakita
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Koshino
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Izumiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Koro
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001650:Bile Duct Neoplasms / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary; D008197:Lymph Node Excision; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil