title: Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929.
abstract: The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be 1 alpha-hydroxy-3alpha-(4'-oxoundec-(5' E)-enyl)-pyrrolizidine and 1beta-hydroxy-3 alpha-(4'-oxoundec-(5 'E)-enyl)-pyrrolizidine, respectively, by comparison with spectral data of synthetic compounds.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. shibuyam@mol.f.u-tokyo.ac.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shibuya
authors.forename: Barry B
authors.initials: BB
authors.lastname: Snider
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ebizuka
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry* / Q000145:classification; D006801:Humans; D019751:Intramolecular Transferases / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; C494514:epohelmin A; C494515:epohelmin B; D019751:Intramolecular Transferases; C021924:lanosterol synthase