An essential connection: link between Hsp70's domains at last.
Communication between the ATPase and substrate binding domains of Hsp70 is critical for regulated interaction between this molecular chaperone and its client proteins. In this issue of Molecular Cell, Jiang et al. (2005) report the structure of an intact Hsp70, revealing critical interactions between the two domains.
D'Silva
Patrick
P
Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, Madison, Wisconsin 53726, USA.
Marszalek
Jaroslaw
J
Craig
Elizabeth A
EA
D000818:Animals; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D017434:Protein Structure, Tertiary
D018840:HSP70 Heat-Shock Proteins