title: Development of a computer-aided diagnosis system for a new modality of renal replacement therapy: an integrated approach combining both peritoneal dialysis and hemodialysis.
abstract: The authors developed a computer-aided diagnosis system that includes a simple clinical test for the chronic renal disease patient who needs an integrated approach that combines both peritoneal dialysis and hemodialysis (PD-HD therapy). In this case study, the system simulated and estimated the dialysis outcome, the ultrafiltration volume and nutritional analysis by employing a pharmacokinetic model, and assessed the peritoneal permeable enhancement that can be a grave complication with peritoneal dialysis. This system requires only a minimum amount of nursing time and may be able to predict the optimal treatment schedule for PD-HD therapy and provide therapeutic monitoring in long-term peritoneal dialysis.
authors.affiliation: Laboratory for Bioinformatics, Graduate School of Systems Life Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. hamada@brs.kyushu-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamada
authors.forename: Shinji
authors.initials: S
authors.lastname: Namoto
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamada
authors.forename: Akihiro C
authors.initials: AC
authors.lastname: Yamashita
authors.forename: Makoto
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D003198:Computer Simulation; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008954:Models, Biological; D010530:Peritoneal Dialysis / Q000379:methods*; D006435:Renal Dialysis / Q000379:methods*; D012984:Software
chemical_list: D015314:Dialysis Solutions