Molecular evolution of human influenza A/H3N2 virus in Asia and Europe from 2001 to 2003.
Hemagglutinin sequences of 146 human influenza A/H3N2 strains identified in respiratory specimens from Asia and Europe during the 2001-2003 influenza seasons were analyzed by DNA sequencing. Our results suggest that four amino acid substitutions, L25I, H75Q, H155T, and Q156H, led to the antigenic conversion of the previously predominant A/Panama/2007/99-like strains to the more recent A/Fujian/411/2002-like strains.
Chi
X Sherry
XS
Applied Immunology and Microbiology Division, Wyeth Vaccines Research, 401 N. Middletown Road, Building 180, Pearl River, NY 10965, USA.
Bolar
Trentice V
TV
Zhao
Ping
P
Tam
John S
JS
Rappaport
Ruth
R
Cheng
Sheau-Mei
SM
D019943:Amino Acid Substitution; D001208:Asia / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis; D005060:Europe / Q000453:epidemiology; D019143:Evolution, Molecular; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA
D004279:DNA, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; C483468:hemagglutinin, human influenza A virus