Inducers and co-inducers of molecular chaperones.
Molecular chaperones, which are mostly heat- or stress-induced proteins (HSPs), not only regulate various cellular functions such as protein folding, refolding of partially denatured proteins, protein transport across membranes, cytoskeletal organization, degradation of disabled proteins, and apoptosis, but also act as cytoprotective factors against deleterious environmental stresses. Recent studies indicated that moderate overexpression of molecular chaperones could confer cells and tissues stress tolerance and provide beneficial effects on various pathological states associated with protein misfolding and protein aggregation. Mild heat shock, transfection of HSP genes, and some chemical compounds are the major means of overexpression of molecular chaperones. In this review, we summarize recent studies of chemical compounds that could induce or enhance the expression of molecular chaperones or HSPs.
Ohtsuka
K
K
Laboratory of Cell and Stress Biology, Department of Environmental Biology, Chubu University, Kasugai, Aichi, Japan. kohtsuka@isc.chubu.ac.jp
Kawashima
D
D
Gu
Y
Y
Saito
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism; D000897:Anti-Ulcer Agents / Q000378:metabolism; D016718:Arachidonic Acid / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D010936:Plant Extracts; D011453:Prostaglandins; D011506:Proteins; D015842:Serine Proteinase Inhibitors; D016718:Arachidonic Acid