title: Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
abstract: The design, synthesis, and structure-activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT(1A) receptor activities are described.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. zhoud@wyeth.com
authors.forename: Dahui
authors.initials: D
authors.lastname: Zhou
authors.forename: Boyd L
authors.initials: BL
authors.lastname: Harrison
authors.forename: Uresh
authors.initials: U
authors.lastname: Shah
authors.forename: Terrance H
authors.initials: TH
authors.lastname: Andree
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Hornby
authors.forename: Rosemary
authors.initials: R
authors.lastname: Scerni
authors.forename: Lee E
authors.initials: LE
authors.lastname: Schechter
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Smith
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Sullivan
authors.forename: Richard E
authors.initials: RE
authors.lastname: Mewshaw
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D048588:Benzoxazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000928:Antidepressive Agents; D048588:Benzoxazines; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A