Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5.
Two novel interleukin-24 (IL-24) splice variants were identified in normal human melanocytes by sequencing cloned polymerase chain reaction (PCR) products that are not expressed in metastatic melanoma. These gene products have been generated by differential skipping of exons 3 (IL-24 delE3) and 5 (IL-24 delE5). IL-24 delE3 has limited sequence identity to the IL-24-interacting protein mda-7s, and IL-24 delE5 is homologous to IL-24.
Allen
M
M
Department of Clinical Pharmacology, Section of Experimental Oncology/Molecular Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria, A-1090.
Pratscher
B
B
Krepler
C
C
Frei
K
K
Schöfer
C
C
Pehamberger
H
H
Müller
M
M
Lucas
T
T
D017398:Alternative Splicing / Q000235:genetics*; D001483:Base Sequence; D002478:Cells, Cultured; D005091:Exons / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008544:Melanocytes / Q000166:cytology / Q000502:physiology*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics*; D017384:Sequence Deletion; D000099180:Interleukin-24
D007378:Interleukins; D012333:RNA, Messenger; D000099180:Interleukin-24