[Association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan].
OBJECTIVE
To investigate the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan.


METHODS
Polymerase chain reaction with sequence-specific primers (PCR-SSP) genotyping method was conducted in 58 ethnic Yi patients with type 2 diabetes mellitus and 82 ethnically matched controls from Chuxiong of Yunnan. Then a study was made on the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes mellitus.


RESULTS
The frequency of HLA-DQA1*0301 allele in the patients with type 2 diabetes mellitus was significantly higher than that in the healthy controls (P=0.002, RR=3.097), and the frequency of HLA-DQA1*0601 in the patients was significantly lower (P=0.025, RR=0.429).


CONCLUSIONS
In Yi nationality of Yunnan, HLA-DQA1*0301 allele may be a susceptible gene and the HLA-DQA1*0601 allele may protect individuals from the risk of diabetes mellitus.
Yang
Hong-ying
HY
The Clinical Laboratory, the Second Affiliated Hospital, Kunming Medical College, Kunming, Yunnan, P. R. China. yy8657@Peoplemail.com.cn
Ren
Chun-feng
CF
Xue
Li
L
Yuan
Hui-yun
HY
Xu
Mian
M
Tai
Wen-lin
WL
Li
Jiang
J
Yang
Yu
Y
Du
Juan
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen