Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population.
A direct correlation between HIV infection and mutation in the chemokine receptor (CCR5) gene has been established. However, such correlation has never been investigated in Lebanon. We report the frequency of the CCR5-delta 32 mutation in a random sample of 209 healthy, HIV-1 seronegative Lebanese aged 19-68. Overall, 4.8% were heterozygous for the mutation. Homozygosity was absent from our sample. The frequency for the CCR5-delta 32 allele was 2.5%. Distribution of the mutation was unaffected by sex, age, religion or educational level. The frequency in the Lebanese population is consistent with that in the origin of the mutation in northern Europe. This could be attributed to a gene flow into the Middle East from northern Europe.
Karam
W
W
Faculty of Public Health, Balamand University, Beirut, Lebanon.
Jurjus
R
R
Khoury
N
N
Khansa
H
H
Assad
C
C
Zalloua
P
P
Jurjus
A
A
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001782:Blood Donors; D005260:Female; D016368:Frameshift Mutation / Q000235:genetics; D017353:Gene Deletion; D051456:Gene Flow / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D018023:HIV Seronegativity; D006579:Heterozygote; D006720:Homozygote; D006784:Hospitals, Teaching; D006801:Humans; D007861:Lebanon; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D019713:Receptors, CCR5 / Q000235:genetics*; D011795:Surveys and Questionnaires
D019713:Receptors, CCR5