[Mast cells in photolesion of the skin and basal cell cancer associated with it].
Morphofunctional features of skin mast cells located in the areas subjected to chronic UV-radiation and in the associated basal cell carcinoma with photoinjure have been studied. Various immunohistochemical methods (chromogranin A, CDla, HLA-DR, CD35, Ki67, P53, Bcl-2, Mcl-1, involucrine) were used. It is found that chronic UV-damage leads to mast cell hyperplasia as well as activation of their synthetic, absorption and secretory functions. It is suggested that mast cell hyperplasia and increase of mast cells neuroendocrine activity provide a risk of basal cell carcinoma development.
Smirnova
I O
IO
Kvetnoĭ
I M
IM
Anichkov
N M
NM
Smirnova
O N
ON
Antonova
I V
IV
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000209:etiology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008407:Mast Cells / Q000737:chemistry / Q000473:pathology / Q000528:radiation effects*; D034701:Mastocytosis, Cutaneous / Q000150:complications*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology*; D014466:Ultraviolet Rays
D000954:Antigens, Surface; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins