title: Association between maternal smoking and low birth weight in Switzerland: the EDEN study.
abstract: OBJECTIVE
  To study the association between maternal smoking during pregnancy and low birth weight (LBW), small-for-gestational-age birth weight (SGA) and preterm birth, and to quantify the population-attributable fractions for these outcomes in Switzerland.
  
  
  METHODS
  Data were gathered for all births in the Canton of Vaud (Switzerland) over a twelvemonth period in 1993-1994. LBW was defined as birth weight <2500 g, SGA as a birth weight <10th percentile for gestational age, and preterm birth as a birth occurring at a gestational age <37 weeks. Maternal smoking before and during pregnancy was recorded.
  
  
  RESULTS
  Of a total of 6284 singleton births, 303 (4.8%) were LBW, 731 (11.7%) were SGA, and 364 (5.8%) were preterm. 19.1% of the mothers reported smoking during pregnancy ("smokers"). Mean birth weight, adjusted for maternal age, parity, parents' occupation and neonates' sex and nationality, was lower by 190 g (95% confidence interval: 150-220) in babies of smokers than those of non-smokers. Comparing smokers to non-smokers, the adjusted odds ratios were 2.7 (2.1-3.5) for LBW, 2.1 (1.7-2.5) for SGA and 1.4 (1.1-1.9) for preterm birth. Past smoking was not associated with the outcomes. Maternal smoking during pregnancy accounted for 22% (15-29%) of all LBW babies in the population, 14% (10-18%) of SGA and 7% (1-12%) of preterm births.
  
  
  CONCLUSIONS
  Maternal smoking during pregnancy was closely associated with LBW, SGA and preterm birth. A large proportion of these perinatal outcomes could have been prevented in Switzerland if maternal smoking had been avoided.
authors.affiliation: Institute of Social and Preventive Medicine, University of Lausanne, Switzerland.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Chiolero
authors.forename: Pascal
authors.initials: P
authors.lastname: Bovet
authors.forename: Fred
authors.initials: F
authors.lastname: Paccaud
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D013557:Switzerland / Q000453:epidemiology