Adherence of triamcinolone acetonide to various intraocular lens materials.
OBJECTIVE
To determine the adherence of triamcinolone acetonide to various intraocular lens (IOL) materials.


METHODS
Department of Ophthalmology, Dokuz Eylül University, Izmir, Turkey.


METHODS
Four IOLs of 4 materials (single-piece poly(methyl methacrylate) [PMMA], 3-piece foldable silicone, 3-piece hydrophobic acrylic, and single-piece hydrophilic acrylic) were first immersed in triamcinolone acetonide (40 mg/mL) for 15 minutes and then bathed in a balanced salt solution for another 15 minutes. Afterward, each lens optic was examined under light microscopy and digital images were obtained with a digital color video camera. The percentage of optic area covered with triamcinolone acetonide was determined by image analysis.


RESULTS
Mean triamcinolone coverage was 7.62% +/- 4.06% (SD) for PMMA IOLs (range 1.97% to 11.43%), 9.09% +/- 4.60% for silicone IOLs (range 4.70% to 15.32%), 8.75 +/- 7.20% for hydrophobic acrylic IOLs (range 1.31% to 16.86%), and 23.16 +/- 8.53% for hydrophilic acrylic IOLs (range 15.02% to 35.12%). Adherence of triamcinolone acetonide to hydrophilic acrylic lenses was statistically significant when compared with other IOL materials.


CONCLUSIONS
Intraoperative triamcinolone injection may obscure visualization intraoperatively and postoperatively, especially in eyes with hydrophilic acrylic lenses, because triamcinolone acetonide seems to have a tendency to adhere to hydrophilic acrylic lenses in vitro.
Arikan
Gul
G
Department of Ophthalmology, Dokuz Eylül University, School of Medicine, Izmir, Turkey.
Saatci
A Osman
AO
Sarioglu
Sulen
S
Sakar
Mustafa
M
Durak
Ismet
I
D000179:Acrylates; D004347:Drug Interactions; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007910:Lenses, Intraocular; D019904:Polymethyl Methacrylate; D012828:Silicones; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D000179:Acrylates; D012828:Silicones; D019904:Polymethyl Methacrylate; D014222:Triamcinolone Acetonide