Effect of vepeside on the function of reproductive system in rats.
Experiments on adult rats showed that a single intravenous injection of antitumor drug vepeside in a MTD (maximum tolerable dose) reduced the reproductive status during periods corresponding to exposure of mature sex cells, spermatocytes, and spermatogonia in male rats and exposure of oocytes in ovulating, mature, and primordial follicles in female rats. Reduction of the male and female reproductive function manifested in increased antenatal mortality of the progeny. The toxic effects of the drug on mature male sex cells caused temporary partial infertility.
Borovskaya
T G
TG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Gol'dberg
V E
VE
Poluektova
M E
ME
Timina
E A
EA
Shchemerova
Yu A
YA
Perova
A V
AV
D000818:Animals; D005047:Etoposide / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects; D005306:Fertilization / Q000187:drug effects; D005313:Fetal Death; D008297:Male; D009865:Oocytes / Q000187:drug effects; D011247:Pregnancy; D018873:Pregnancy Rate; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects
D005047:Etoposide