CARD games between virus and host get a new player.
A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD-CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.
Johnson
Cynthia L
CL
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gale
Michael
M
D000818:Animals; D020169:Caspases / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D014777:Virus Diseases / Q000201:enzymology* / Q000821:virology*
D020169:Caspases