Role of glucocorticoids in dopamine-related neuropsychiatric disorders.
'Psychoneuroendocrinology' is now quickly emerging as a hot interdisciplinary research field that addresses the interplay between neuronal and endocrine signaling in psychiatric diseases. Both glucocorticoid hormones and dopamine have an important role in maintaining normal brain functions. In this review, molecular and mechanistic aspects of glucocorticoid effects on brain function and behavior will be discussed with specific reference to dopamine signaling.
Van Craenenbroeck
Kathleen
K
Laboratory for Eukaryotic Gene Expression and Signal Transduction, LEGEST, Department of Molecular Biology, Ghent University-UGent, K.L. Ledeganckstraat 35, 9000 Gent, Belgium.
De Bosscher
Karolien
K
Vanden Berghe
Wim
W
Vanhoenacker
Peter
P
Haegeman
Guy
G
D000818:Animals; D016739:Behavior, Addictive / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000503:physiopathology; D004298:Dopamine / Q000235:genetics / Q000502:physiology*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation / Q000502:physiology; D005938:Glucocorticoids / Q000235:genetics / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology; D020239:Receptor Cross-Talk / Q000502:physiology; D011954:Receptors, Dopamine / Q000235:genetics / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology; D015398:Signal Transduction
D005938:Glucocorticoids; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D011965:Receptors, Glucocorticoid; D004298:Dopamine