title: Microbial transformation of fraxinellone by Aspergillus niger.
abstract: Microbial transformation of fraxinellone (1) by Aspergillus niger (AS 3.421) has been carried out. Two converted products, dasycarpol (2) and a new compound fraxinigerllone (3) were obtained. Their structures have been identified on the basis of spectroscopic methods. Dasycarpol shows moderate inhibitory activity on lung cancer cell line A549.
authors.affiliation: Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
authors.forename: R-L
authors.initials: RL
authors.lastname: Yang
authors.forename: T-L
authors.initials: TL
authors.lastname: Jia
authors.forename: R-Q
authors.initials: RQ
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism* / Q000494:pharmacology; D001234:Aspergillus niger / Q000378:metabolism*; D001572:Benzofurans / Q000378:metabolism* / Q000494:pharmacology; D045744:Cell Line, Tumor; D036905:Dictamnus / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; C075391:fraxinellone