[Cocaine and trisomy 8 associated with prenatal diagnosis of corpus callosum agenesis].
We report the case of a newborn presenting an agenesis of corpus callosum (ACC) discovered in the prenatal period and initially related to cocaine exposure during the first trimester of gestation. The cytogenetic analysis revealed a trisomy 8 mosaicism. The putative role of prenatal cocaine exposure and mosaicism for chromosome 8 in ACC are discussed. This report emphasizes the specific analysis of chromosome 8 by using fluorescence in situ hybridization as a complement to routine cytogenetic analysis for prenatal diagnosis of ACC.
Gonzales
E
E
Service de Réanimation Néonatale.
Caeymaex
L
L
Aboura
A
A
Vial
M
M
De Laveaucoupet
J
J
Labrune
P
P
Tachdjian
G
G
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000235:genetics; D061085:Agenesis of Corpus Callosum; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009030:Mosaicism; D011247:Pregnancy; D014314:Trisomy / Q000235:genetics*
D003042:Cocaine