title: Multiple primary malignancies. A rare case of five metachronous tumours.
abstract: The Authors report on a patient admitted several times for the occurrence of five multiple metachronous primary malignancies (laryngeal carcinoma, endometrial adenocarcinoma, rectal cancerous polyp, Vaterpapilla carcinoma and transverse colon cancer). All five carcinomas were independent primary cancers and the lenghty time intervals between the onsets of each individual tumours confirm their independent non-metastatic origin. Classification, pathogenesis, genetic and environmental interactions of these tumours are discussed; in the case reported a family history of colon cancer was present, while no genetic markers abnormalities or chronic exposure to carcinogens were found. The case report suggests that an aggressive, appropriate surgical approach together with a through follow-up monitoring offers a chance of long-term survival for patients with metachronous malignant primary tumours.
authors.affiliation: University of Catania, Department of Surgery, Unit of General Surgery.
authors.forename: F
authors.initials: F
authors.lastname: Mosca
authors.forename: A
authors.initials: A
authors.lastname: Stracqualursi
authors.forename: A
authors.initials: A
authors.lastname: Persi
authors.forename: T R
authors.initials: TR
authors.lastname: Portale
authors.forename: O
authors.initials: O
authors.lastname: Zappalà
authors.forename: S
authors.initials: S
authors.lastname: Latteri
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000601:surgery*