title: [Retrospective study of a series of 26 carcinomatous meningitis secondary to lung cancer].
abstract: Carcinomatous meningitis occur in approximately 5 to 18% of bronchial carcinoma. We report here the analysis of a retrospective study of 26 cases of carcinomatous meningitis secondary to a bronchial carcinoma. The most frequently involved histological types are adenocarcinoma and small cell lung cancer. The diagnosis is difficult because of the clinical polymorphism and the inconstant presence of neoplasic cells in the cerebrospinal fluid. The prognosis is very poor with a median survival time of 4 weeks. Development of new molecules as well as an earlier diagnosis could contribute to improve the outcome.
authors.affiliation: Service de pneumologie, Hôpital Lyautey, Hôpitaux Universitaires de Strasbourg, 1 rue des Canonniers, 67000 Strasbourg.
authors.forename: Valérie
authors.initials: V
authors.lastname: Hammerer
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Pauli
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Quoix
mesh_terms: D000230:Adenocarcinoma / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary; D002555:Cerebrospinal Fluid / Q000166:cytology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate