Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions.
Coupling between cell adhesion and the actin cytoskeleton is thought to require a stable link between the cadherin-catenin complex and actin that is mediated by alpha-catenin. In this issue of Cell, the Weis and Nelson groups call this static model into question, showing that alpha-catenin can directly regulate actin dynamics (Drees et al., 2005 and Yamada et al., 2005).
Gates
Julie
J
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Peifer
Mark
M
D000199:Actins / Q000378:metabolism*; D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D008954:Models, Biological; D046912:Multiprotein Complexes; D051178:alpha Catenin / Q000378:metabolism*
D000199:Actins; D046912:Multiprotein Complexes; D051178:alpha Catenin