Rapid deprotection of N-Boc amines by TFA combined with freebase generation using basic ion-exchange resins.
The deprotection of N-Boc amines was rapidly accomplished using 5 equivalents of TFA in methylene chloride in a focused microwave instrument with irradiation at 60 degrees C for 30 min. The freebase amines are then obtained by scavenging the crude reaction mixture with the basic Amberlyst A-21 ion-exchange resin. This procedure is suitable for the parallel deprotection of N-Boc amines.
Srinivasan
Natarajan
N
School of Chemistry, University of Southampton, Southampton, SO17 1BJ, United Kingdom.
Yurek-George
Alexander
A
Ganesan
A
A
D000588:Amines / Q000737:chemistry*; D005563:Formic Acid Esters / Q000737:chemistry*; D007475:Ion Exchange Resins / Q000737:chemistry*; D013997:Time Factors; D014269:Trifluoroacetic Acid / Q000737:chemistry*
D000588:Amines; D005563:Formic Acid Esters; D007475:Ion Exchange Resins; C000345:t-butyloxycarbonyl group; D014269:Trifluoroacetic Acid