title: Serum immunoglobulin levels do not affect antibody responses to influenza HA vaccine in preterm infants.
abstract: Antibody responses to two doses of influenza hemagglutinin (HA) vaccine were evaluated in 45 previously unimmunized preterm infants aged 6-11 months before the 2003/2004 influenza season. Twenty-three (51.1%), 21 (46.6%) and 2 (4.4%) of the subjects acquired protective (>or=1:40) hemagglutination inhibition (HI) antibody titers after vaccination for A/New Caledonia (H1N1), A/Panama (H3N2) and B/Shandong, respectively. Antibody responses to A (H1N1), A (H3N2) appeared to be comparable to those reported on full-term infants of similar ages vaccinated with the identical vaccine. Serum IgG levels at vaccination had no positive association with antibody responses on univariate or multivariate analysis, indicating that prolonged hypogammaglobulinemia after 6 months of age in preterm infants was not a factor to affect antibody responses to influenza HA vaccine.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812 8582, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Kusuhara
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Saito
authors.forename: Shunji
authors.initials: S
authors.lastname: Hikino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Murayama
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamashita
authors.forename: Naoko
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Johji
authors.initials: J
authors.lastname: Kukita
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinukawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation; D005260:Female; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male
chemical_list: D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines