title: Chromosomal inversion discovered in C3H/HeJ mice.
abstract: Mice of the inbred mouse strain C3H/HeJ have been shown to be homozygous for a chromosomal inversion on Chromosome (Chr) 6. The inversion encompasses about 20% of the chromosome from approximately 73 Mb to approximately 116 Mb. The importance of this finding is that linkage crosses using C3H/HeJ will show no recombination in this region of Chr 6. The inversion has no apparent effect on the phenotype of C3H/HeJ mice and its presence should not affect biological studies; however, use of C3H/HeJ mice for genetic analysis of Chr 6 should be avoided or the results interpreted with the inversion in mind. The inversion has been named In(6)1J (inversion Chr 6, Jackson 1).
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
authors.forename: Ellen C
authors.initials: EC
authors.lastname: Akeson
authors.forename: Leah Rae
authors.initials: LR
authors.lastname: Donahue
authors.forename: Wesley G
authors.initials: WG
authors.lastname: Beamer
authors.forename: Kathy L
authors.initials: KL
authors.lastname: Shultz
authors.forename: Cheryl
authors.initials: C
authors.lastname: Ackert-Bicknell
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Rosen
authors.forename: Jennifer
authors.initials: J
authors.lastname: Corrigan
authors.forename: Muriel T
authors.initials: MT
authors.lastname: Davisson
mesh_terms: D000818:Animals; D007446:Chromosome Inversion; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*