Bioengineering of a cellulosic fabric for insecticide delivery via grafted cyclodextrin.
beta-Cyclodextrin (beta-CD) can be easily grafted onto cellulosic textiles through covalent bonds. In such a way beta-CD empty cavities provide an efficient tool for entrapping different kinds of hydrophobic molecules on the surface of the fabric and releasing them slowly in time. The capability of cyclodextrins to include hydrophobic molecules such as fragrances, antimicrobial agents, and other chemicals can be then exploited to produce new grafted textiles with peculiar and useful performances. In this work we report the inclusion of two different products, the pyrethroid insecticide permethrin (PERM) and the insect repellent N,N-diethyl-m-toluamide (DEET), into beta-CD molecules grafted on cotton fabric. UV-vis spectrophotometry and thermal analysis confirmed the presence of the guest molecules on the fabric surface. Bioassays were carried out on two mosquito species of medical importance, Aedes aegypti and Anopheles stephensi; knock down effect and mortality were measured using standard World Health Organization (WHO) cone tests. Repellency and irritancy (blood feeding inhibition) were also measured using cage tests and a baited tunnel device. PERM-treated fabrics kept the insecticidal/irritant efficacy even for a long time after the treatment, whereas DEET activity lasted more shortly.
Romi
Roberto
R
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy.
Lo Nostro
Pierandrea
P
Bocci
Eugenio
E
Ridi
Francesca
F
Baglioni
Piero
P
D000330:Aedes; D000818:Animals; D000852:Anopheles; D001698:Biomedical Engineering; D001709:Biotechnology; D002482:Cellulose / Q000737:chemistry; D003671:DEET / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D005260:Female; D007306:Insecticides / Q000008:administration & dosage* / Q000737:chemistry; D008958:Models, Molecular; D026023:Permethrin / Q000008:administration & dosage / Q000737:chemistry; D013053:Spectrophotometry; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry
D007306:Insecticides; D047392:beta-Cyclodextrins; D003671:DEET; D026023:Permethrin; D002482:Cellulose