Ultrastructural organization of epiphysis in rats under the action of electromagnetic fields and during mammary carcinogenesi.
Experiments conducted by the authors, as well as clinical studies, show that in addition to hormonal mis-balance, development of mammary gland cancer is significantly influenced by the action of low frequency electromagnetic fields on epiphysis. By reducing the production of melatonin it increases the risk of development of mammary gland tumors. The review of scientific literature indicates that pinealocytes are the main morphological substrate responsible for functional activity of pineal cells. When estimating large specific weight of lipids, many researchers point to the dependence of their presence in epiphysis on the level of melatonin. It is thought that hormones of pineal cells are deposited in the form of lipid drops. The most characteristic feature in the structure of pinealocytes is the presence of large number of various size complexes in their bodies and appendices. According to many authors this could be the form of depositing the secretory products of pinealocytes, such as melatonin, biological amines, etc. Ultrastructure characteristic of pinealocytes described in the review provides deeper understanding of the fine structure morpho-physiology of epiphysis, enable to point out the peculiarities of its functionality under the influence of electromagnetic fields and discover the organizational structure of pineal body at a time of the mammary gland tumor development.
Beniashvili
D I
DI
Wolfson Medical Center, Department of Pathology, Holon.
Baazov
D Sh
DSh
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure*; D004574:Electromagnetic Fields; D004838:Epiphyses / Q000528:radiation effects* / Q000648:ultrastructure*; D008321:Mammary Glands, Animal / Q000648:ultrastructure*; D008325:Mammary Neoplasms, Experimental / Q000209:etiology*; D051381:Rats