1,2,4,5-Tetraoxacycloalkanes: synthesis and antimalarial activity.
In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.
Masuyama
A
A
Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. toratora@chem.eng.osaka-u.ac.jp
Wu
J-M
JM
Nojima
M
M
Kim
H-S
HS
Wataya
Y
Y
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans
D000962:Antimalarials; D003516:Cycloparaffins