Comparison of short-term outcome between surgical and clinical treatment in temporal lobe epilepsy: a prospective study.
OBJECTIVE
To compare the efficacy of medical and surgical treatment for refractory mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE).


METHODS
A prospective controlled non-randomized study of 26 patients with MTLE who underwent surgical treatment and 75 patients with MTLE who underwent medical treatment between August 2002 and October 2004. All patients failed to achieve seizure control with at least two first line antiepileptic drugs (AED) for partial seizures before entering the study. We used Kaplan-Meier survival analyses as a function of time of seizure recurrence to obtain estimates of 95% confident interval of seizure freedom and log-rank test to compare the status of seizure control between the two groups.


RESULTS
The cumulative proportion of patients free of all seizures (Engel's class IA) was higher in the surgical group (73%) compared to the clinical group (12%) (p<0.0001). In the surgical group, 2 of 26 patients (7.7%) had transient adverse effects and 2 of 26 patients (7.7%) had a permanent deficit related to the surgical procedure. In the clinical group 7 patients (9.3%) major adverse events during follow-up, including burns and status epilepticus.


CONCLUSIONS
Surgical treatment for patients with MTLE who failed to achieve seizure control with two previous AED regimens was more efficient than medical treatment with further trials of AED.
Yasuda
Clarissa L
CL
Department of Neurology, State University of Campinas, Campinas, SP 13083-970, Brazil.
Tedeschi
Helder
H
Oliveira
Evandro L P
EL
Ribas
Guilherme C
GC
Costa
Alberto L C
AL
Cardoso
Tânia A M O
TA
Montenegro
Maria A
MA
Guerreiro
Carlos A M
CA
Guerreiro
Marilisa M
MM
Li
Li M
LM
Cendes
Fernando
F
D000328:Adult; D038481:Anterior Temporal Lobectomy; D000927:Anticonvulsants / Q000627:therapeutic use*; D018572:Disease-Free Survival; D004359:Drug Therapy, Combination; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
D000927:Anticonvulsants