Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation.
Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7 microM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 microM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.
Kang
Hyun-Mi
HM
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.
Ryong Kim
Ju
J
Jeong
Tae-Sook
TS
Choi
Sung-Gyu
SG
Ryu
Young-Han
YH
Taeg Oh
Goo
G
Baek
Nam-In
NI
Kwon
Byoung-Mog
BM
D029661:Alnus / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000473:pathology; D050197:Atherosclerosis / Q000473:pathology; D036381:Diarylheptanoids / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005638:Fruit / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000378:metabolism*; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D000097566:Cyclophanes
D000975:Antioxidants; D036381:Diarylheptanoids; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; C509355:acerogenin L; D000097566:Cyclophanes; C509356:garugamblin-3