Dendritic cell interactions and cytokine production.
The dendritic cell lineage comprises cells at various stages of functional maturation that are able to induce and regulate the immune response against antigens and thus function as initiators of protective immunity. The signals that determine the given dendritic cell functions depend mostly on the local microenvironment and on the interaction between dendritic cells and microorganisms. These interactions are complex and very different from one pathogen to another; nevertheless, both shared and unique responses have been observed using global genomic analyses. In this review, we have focused on the study of host-pathogen interactions using a genome-wide transcriptional approach with a focus on cytokine family members.
Foti
M
M
University of Milano-Bicocca, Department of Biotechnology Bioscience, Italy.
Granucci
F
F
Ricciardi-Castagnoli
P
P
D000818:Animals; D019070:Cell Lineage; D018925:Chemokines / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D020869:Gene Expression Profiling; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007111:Immunity, Cellular / Q000502:physiology; D007113:Immunity, Innate / Q000502:physiology; D007376:Interleukin-2 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D014158:Transcription, Genetic
D018925:Chemokines; D016207:Cytokines; D007376:Interleukin-2