title: [Various approaches of therapeutic vaccination for the treatment of HIV type 1 infection].
abstract: HIV-1 infection is a major pandemic situation. With the advent of highly active antiretroviral therapy (HAART), morbidity and mortality associated with HIV-1 infection have been dramatically reduced. However, HAART does not enable eradication of the virus. The efficacy of these new regimens is limited by problems over long-term use such as toxicity and resistance. Therapeutic vaccination is an alternative approach to HIV-1 infection. The main aim is to boost and reinforce virus-specific host immune responses. Several immunogens and schedules of immunization have been tested. In this review, various strategies designed for therapeutic vaccines for HIV-1 infection are presented.
authors.affiliation: Service de virologie, UPRES EA 3610, CHRU de Lille.
authors.forename: M
authors.initials: M
authors.lastname: Lazrek
authors.forename: P E
authors.initials: PE
authors.lastname: Lobert
authors.forename: A
authors.initials: A
authors.lastname: Goffard
authors.forename: C
authors.initials: C
authors.lastname: Schanen
authors.forename: A
authors.initials: A
authors.lastname: Dewilde
authors.forename: L
authors.initials: L
authors.lastname: Bocket
authors.forename: D
authors.initials: D
authors.lastname: Hober
mesh_terms: D016915:AIDS Vaccines / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans
chemical_list: D016915:AIDS Vaccines