Low levels of pigment epithelium-derived factor in highly myopic eyes with chorioretinal atrophy.
OBJECTIVE
To determine the concentration of pigment epithelium-derived factor (PEDF) in the aqueous humor of highly myopic eyes.


METHODS
Observational case series.


METHODS
The PEDF concentration in the aqueous humor of 23 eyes of 17 patients with high myopia (axial length >26 mm) who underwent cataract surgery was measured by enzyme-linked immunosorbent assay.


RESULTS
The mean concentration of PEDF in eyes with high myopia (0.54 +/- 0.12 microg/ml) was significantly lower than that in control eyes (0.86 +/- 0.04 microg/ml, P = .0022). The PEDF level in myopic eyes with chorioretinal atrophy (0.32 +/- 0.05 microg/ml) was lower than that in myopic eyes without chorioretinal atrophy (0.71 +/- 0.12 microg/ml; P = .041) and control eyes (P = .0003).


CONCLUSIONS
The significantly lower concentration of PEDF in eyes with chorioretinal atrophy-associated high myopia probably resulted from degeneration of the retinal pigment epithelial cells and/or the retinal ganglion cells that are the main sources of PEDF in the eye.
Ogata
Nahoko
N
Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan. ogata@takii.kmu.ac.jp
Imaizumi
Masahito
M
Miyashiro
Miki
M
Arichi
Miwa
M
Matsuoka
Masato
M
Ando
Akira
A
Matsumura
Miyo
M
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D001284:Atrophy; D002387:Cataract Extraction; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism*; D012160:Retina / Q000378:metabolism* / Q000473:pathology*; D015843:Serpins / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor