title: [Two cases of postoperative local skin recurrence of breast cancer successfully treated with chemotherapy of irinotecan hydrochloride (CPT-11)].
abstract: Breast cancer is a neoplasm which is considered well-responsive to chemotherapy, radiation therapy and endocrine therapy. However, recurrent breast cancer will grow developing a tolerance to the variety of therapies. We reported two cases of recurrent breast cancer which showed a good response to CPT-11. These tumors were already refractory to anthracycline and taxanes. A weekly CPT-11 infusion therapy was effective to the recurrent skin and soft tissue lesions (CR and PR), and the tumor markers (CEA and CA15-3) markedly declined. CPT-11 is a useful treatment for multiple drug resistant recurrent breast cancer.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Nanao
authors.initials: N
authors.lastname: Negishi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002272:Carcinoembryonic Antigen / Q000032:analysis; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D000077146:Irinotecan; D002166:Camptothecin