[Heme oxygenase induction in rat heart and vessels and peroxidative resistance of erythrocytes during hemolytic anemia development].
The hemolytic anemia development caused by phenylhydrazine injection (7 mg/100 g b.w.) was shown to be caused by the decreasing of both catalase activity and glutathione content in erythrocytes, and by the increasing of spontaneouse hemolysis level of these cells in blood stream. The increasing of heme oxygenase activity and TBA-active products in rat heart and vessels were revealed 24 hrs after phenylhydrazine injection. Possible mechanisms of heme oxygenase-1 induction under hypoxia as response to the hemolytic anemia development and it's role in defense of the cells from damage are discussed.
Kaliman
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PA
Pavychenko
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OV
D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000201:enzymology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis / Q000378:metabolism; D001808:Blood Vessels / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002374:Catalase / Q000032:analysis / Q000378:metabolism; D052279:Creatine Kinase, MB Form / Q000032:analysis / Q000378:metabolism; D004790:Enzyme Induction; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005978:Glutathione / Q000032:analysis / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D006461:Hemolysis; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010659:Phenylhydrazines / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism
D010659:Phenylhydrazines; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; D002374:Catalase; D006419:Heme Oxygenase (Decyclizing); D001219:Aspartate Aminotransferases; D052279:Creatine Kinase, MB Form; D005978:Glutathione