title: New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.
abstract: A suitable solid-phase approach, based on Fmoc/(t)Bu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
authors.affiliation: Instituto de Química Médica Juan de la Cierva, 3, 28006 Madrid, Spain.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Alonso De Diego
authors.forename: Marta
authors.initials: M
authors.lastname: Gutiérrez-Rodríguez
authors.forename: M Jesús
authors.initials: MJ
authors.lastname: Pérez de Vega
authors.forename: Diego
authors.initials: D
authors.lastname: Casabona
authors.forename: Carlos
authors.initials: C
authors.lastname: Cativiela
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
authors.forename: Rosario
authors.initials: R
authors.lastname: Herranz
authors.forename: Edurne
authors.initials: E
authors.lastname: Cenarruzabeitia
authors.forename: Diana
authors.initials: D
authors.lastname: Frechilla
authors.forename: Joaquín
authors.initials: J
authors.lastname: Del Río
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Jimeno
authors.forename: M Teresa
authors.initials: MT
authors.lastname: García-López
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D006624:Hippocampus / Q000187:drug effects; D015394:Molecular Structure; D016202:N-Methylaspartate / Q000633:toxicity; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017470:Receptors, Glutamate / Q000378:metabolism; D013329:Structure-Activity Relationship; D014320:Triphenylmethyl Compounds / Q000737:chemistry
chemical_list: D018696:Neuroprotective Agents; D010455:Peptides; D017470:Receptors, Glutamate; D014320:Triphenylmethyl Compounds; D016202:N-Methylaspartate