[Genes causing parathyroid diseases].
Discovery of Gcm2 as an essential transcription factor for parathyroid gland development disclosed another, unexpected source of circulating parathyroid hormone (PTH), the thymus. A recent phylogenetic analysis of Gcm2 has led to a new theory that parathyroid glands in tetrapods were transformed from the gills of fish during evolution. I review genes involved in the pathogenesis of hyper- and hypo-function of parathyroid glands as well as in the development of parathyroid tumors.
Ikeda
Kyoji
K
National Center for Geriatrics and Gerontology.
D000818:Animals; D006801:Humans; D006961:Hyperparathyroidism / Q000235:genetics*; D007011:Hypoparathyroidism / Q000235:genetics*; D009479:Neuropeptides / Q000235:genetics; D009687:Nuclear Proteins; D010282:Parathyroid Neoplasms / Q000235:genetics*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics
C454900:CDC73 protein, human; C119532:GCM2 protein, human; D009479:Neuropeptides; D009687:Nuclear Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins