Late recurrence of uterine Mullerian adenosarcoma as heterologous sarcoma: Three recurrences in 8 months increasing in number and grade of sarcomatous components.
BACKGROUND
Uterine Mullerian adenosarcoma (UMA) is a rare and low-grade variant of mixed mesodermal tumor. UMA recurrences including heterologous sarcomatous elements are extremely rare, with only 3 cases reported thus far.


METHODS
We present a case of UMA recurring as heterologous sarcoma three times in 8 months for 9.4 years after primary treatment. The number and grade of sarcomatous components increased with each recurrence eventually resulting in loss of the patient.


CONCLUSIONS
The presence of multiple sarcomatous elements of high histological grade in the recurrent tumor following UMA may indicate an unfavorable prognosis with common recurrences and fatal outcome. All UMA patients carry risk of late recurrence, therefore, they should receive long-term follow-up.
Taçkin
Salih
S
Department of Obstetric and Gynecology, Ankara University, Faculty of Medicine, Ankara, Turkey.
Bozaci
Elif Aylin
EA
Sönmezer
Murat
M
Ekinci
Cemil
C
Ortaç
Firat
F
D018195:Adenosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*