[Infertility in the Klinefelter syndrome].
The Klinefelter syndrome is characterized by one or more extra X-chromosomes, deficient androgens, increased gonadotropines, fibrosis and hyalinization of the seminiferous tubules, small testes, gynecomastia, disproportionately long legs, sparse facial hair, and diminished sexual activity. The incidence of Klinefelter syndrome in the general population is 0.1-0.2%, some 3% among infertile patients, and approximately 11% in patients with aspermia. In very rare cases, these patients may manifest focal residua of spermatogenesis. Employing the ICSI method (intracytoplasmic sperm injection into an oocyte), a patient may be helped to father a child. There is, however an increased risk of such a child being born with a chromosomal aberration.
Glander
H-J
HJ
Andrologie, Klinik für Dermatologie, Venerologie und Allergologie der Universität Leipzig. glah@medizin.uni-leipzig.de
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000188:drug therapy / Q000235:genetics*; D007713:Klinefelter Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D008297:Male; D010641:Phenotype; D020554:Sperm Injections, Intracytoplasmic; D013091:Spermatogenesis; D013739:Testosterone / Q000627:therapeutic use
D013739:Testosterone