title: [Experimental study on action of acupoint embedding thread on ANCA in the rat of ulcerative colitis].
abstract: OBJECTIVE
  To observe therapeutic effect of acupoint embedding thread therapy on ulcerative colitis and to study the mechanism.
  
  
  METHODS
  The rat model of ulcerative colitis was developed with 2,4-dinitrochlorobenzene method. The 20th day after the end of model development, they were randomly divided into a model group, a salicylazosulfapyridine (SASP) treatment group and an acupoint embedding thread therapy group. The SASP treatment group were treated with intragastrical perfusion of 4.5% SASP suspension, and the acupoint embedding thread therapy group were treated with embedding thread at "Zusanli" (ST 36) and "Shangjuxu" (ST 37). Anti-neutrophil cytoplasmic antibody (ANCA) was detected with indirect immunofluorescence, and the pathological changes were investigated with pathological tissue section technique.
  
  
  RESULTS
  The positive rate of ANCA reached to 62.5% in the rat with ulcerative colitis with significant differences among the 3 groups. After treatment, the positive rate of ANCA was decreased in the two treatment groups (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  Acupoint embedding thread therapy has definite therapeutic effect on ulcerative colitis and the mechanism is possibly related with the decrease of ANCA.
authors.affiliation: Provincial Center for Clinical Laboratory, Guizhou Provincial People's Hospital, Guiyang 550002, China. DXL@public.GZ.cn
authors.forename: Yang
authors.initials: Y
authors.lastname: Zou
authors.forename: Zhu-Liang
authors.initials: ZL
authors.lastname: Zou
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Yang
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Zhou
authors.forename: Gui-Zhen
authors.initials: GZ
authors.lastname: Ou
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic; D003093:Colitis, Ulcerative / Q000628:therapy; D051381:Rats
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic