Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy?
The roles of growth factor receptors and numerous downstream growth regulatory pathways are of increasing interest in neuro-oncology. These pathways have been extensively studied in gliomas but only recently analyzed in meningiomas. This article reviews current research on the growth factor receptor-Ras-Raf-1-MEK-1-MAPK, PI3K-Akt/PKB, PLC-gamma1-PKC, phospholipase A2-cyclooxygenase, and TGF-beta receptor-Smad pathways that appear to regulate meningioma growth and inhibit apoptosis. Sites along these receptor/kinase cascades that might be targeted by novel therapies are also discussed.
Johnson
Mahlon
M
Department of Pathology, University of Tennessee, Graduate School of Medicine, Knoxville, Tennessee 37920, USA. mdjohnso@mc.utmk.edu
Toms
Steven
S
D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008495:Medical Oncology / Q000639:trends; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008579:Meningioma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008938:Mitosis; D017978:Receptors, Growth Factor / Q000378:metabolism*; D015398:Signal Transduction
D000970:Antineoplastic Agents; D017978:Receptors, Growth Factor