title: Thymic carcinoma in a child with HIV infection.
abstract: HIV infection predisposes to cancer during childhood. In addition to the AIDS-defining non-Hodgkin lymphoma (NHL) and Kaposi sarcoma, a range of other lymphoid malignancies and solid tumors have been described. We report the first case of an HIV-positive child with thymic carcinoma in the setting of regressing thymic cysts. The tumor expressed CKIT but failed to respond to imatinab mesylate after a transient response to multiagent chemotherapy. This case extends the spectrum of pediatric malignancy in the setting of HIV and suggests that patients with presumed benign thymic cysts require ongoing surveillance.
authors.affiliation: Division of Pediatric Hematology-Oncology, The University of North Carolina, Chapel Hill, North Carolina 27599-7220, USA.
authors.forename: Morgan
authors.initials: M
authors.lastname: McDonald
authors.forename: Thomas
authors.initials: T
authors.lastname: McLean
authors.forename: Thomas
authors.initials: T
authors.lastname: Belhorn
authors.forename: Scott Victor
authors.initials: SV
authors.lastname: Smith
authors.forename: Lynn Ansley
authors.initials: LA
authors.lastname: Fordham
authors.forename: Charles
authors.initials: C
authors.lastname: Woods
authors.forename: Julie
authors.initials: J
authors.lastname: Blatt
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001549:Benzamides; D002648:Child; D018450:Disease Progression; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008297:Male; D008476:Mediastinal Cyst / Q000150:complications / Q000175:diagnosis; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012074:Remission Induction; D013945:Thymoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate