title: [Recent findings on scleral extracellular matrix and matrix metalloproteinases in the development of myopia].
abstract: Myopia is the most common eye disorder worldwide. So far there is no effective treatment for the disease. Recent findings indicated that the remodeling of scleral extracellular matrix (ECM) plays an important role in the development of myopia. The dynamic changes of matrix metalloproteinases in myopia (MMPs) activity, one of the most important enzymes that regulates the ECM, has a significant correlation with myopia. This review gives the latest findings about ECM and MMPs in the development of myopia.
authors.affiliation: Department of Ophthalmology, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai 200031, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Long
authors.forename: Ren-yuan
authors.initials: RY
authors.lastname: Chu
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009216:Myopia / Q000201:enzymology* / Q000473:pathology; D012590:Sclera / Q000201:enzymology* / Q000473:pathology
chemical_list: D020782:Matrix Metalloproteinases