[Comparative studies on pharmacological effects of the main chemical constituents of Peucedanum praeruptorum from He'nan and Jiangxi].
OBJECTIVE
To compare the pharmacological effect of the main coumarin constituents of Peucedanum praeruptorum from Jiangxi and He'nan.


METHODS
The constituents were isolated by column chromatography on silica gel and ODS and identified by NMR and MS spectroscopic methods. The antitussive, expectorant and anti-inflammatory effects of main coumarin constituents of P. praeruptorum observed in the present study.


RESULTS
The main constituents of P. praeruptorum from both Jiangxi and He'nan showed the significant antitussive and anti-inflammatory effects without obviously expectorant effect.


CONCLUSIONS
The pharmacological effects of the main coumarin constituents of Qian-hu from Jiangxi and He'nan are similar.
Zhang
Cun
C
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
Li
Wen
W
Xiao
Yong-qing
YQ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D000996:Antitussive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D002681:China; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000996:Antitussive Agents; D003374:Coumarins; D004365:Drugs, Chinese Herbal; C030123:coumarin