Frequent importation of enterovirus 71 from surrounding countries into the local community of Yamagata, Japan, between 1998 and 2003.
Phylogenetic analysis of 45 enterovirus 71 (EV71) isolates for 6 years in Yamagata, Japan, clarified that the annual outbreak of hand-foot-and-mouth disease was due to four genetically distinct subgenogroups, including a novel "B5." Our results suggest that the importation of EV71 from surrounding countries has had a major epidemiological impact on the local community used in our study.
Mizuta
K
K
Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi 1-6-6, Yamagata, 990-0031 Japan. mizutak@pref.yamagata.jp
Abiko
C
C
Murata
T
T
Matsuzaki
Y
Y
Itagaki
T
T
Sanjoh
K
K
Sakamoto
M
M
Hongo
S
S
Murayama
S
S
Hayasaka
K
K
D036022:Capsid Proteins / Q000235:genetics; D002675:Child, Preschool; D004196:Disease Outbreaks; D004770:Enterovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012621:Seasons; D017422:Sequence Analysis, DNA
D036022:Capsid Proteins