Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma.
Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.
Zhukova
N A
NA
Laboratory of Pharmacological Studies, N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk.
Semenov
D E
DE
Sorokina
I V
IV
Tolstikova
T G
TG
Pozdnyakova
S V
SV
Grek
O R
OR
D000818:Animals; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D000094062:Betulinic Acid
D009828:Oleanolic Acid; C508784:(3-oxo-20(29)-lupene-28-oyl)-3-aminopropionamide; D000094062:Betulinic Acid; C118308:betulonic acid