title: Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model.
abstract: Beta amyloid (Abeta) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of Abeta is considered a primary therapeutic target. Immunization with Abeta can reduce Abeta burden and pathological features in transgenic AD model mice. Transgenic potato plants were made using genes encoding 5 tandem repeats of Abeta1-42 peptides with an ER retention signal. Amyloid precursor protein transgenic mice (Tg2576) fed with transgenic potato tubers with adjuvant showed a primary immune response and a partial reduction of Abeta burden in the brain. Thus, Abeta tandem repeats can be expressed in transgenic potato plants to form immunologically functional Abeta, and these potatoes has a potential to be used for the prevention and treatment of AD.
authors.affiliation: Plant Cell Biotechnology Lab., Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-335, Republic of Korea.
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Youm
authors.forename: Hee
authors.initials: H
authors.lastname: Kim
authors.forename: Jee Hye Lo
authors.initials: JH
authors.lastname: Han
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Jang
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Ha
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-Jung
authors.forename: Jae Heung
authors.initials: JH
authors.lastname: Jeon
authors.forename: Cheol Yong
authors.initials: CY
authors.lastname: Choi
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Hyun Soon
authors.initials: HS
authors.lastname: Kim
authors.forename: Hyouk
authors.initials: H
authors.lastname: Joung
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control*; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D007114:Immunization; D007532:Isoleucine / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D008969:Molecular Sequence Data; D030821:Plants, Genetically Modified; D058225:Plaque, Amyloid / Q000235:genetics / Q000473:pathology; D011198:Solanum tuberosum / Q000235:genetics* / Q000378:metabolism; D020080:Tandem Repeat Sequences / Q000235:genetics; D013997:Time Factors; D014612:Vaccines / Q000627:therapeutic use
chemical_list: D016229:Amyloid beta-Peptides; D014612:Vaccines; D007532:Isoleucine