title: The evidence for magnetic resonance imaging as an outcome measure in proof-of-concept rheumatoid arthritis studies.
abstract: Magnetic resonance imaging (MRI) has now been used extensively in cross-sectional and observational studies as well as in controlled clinical trials to assess disease activity and joint damage in rheumatoid arthritis (RA). MRI measurements or scores for erosions, bone edema, and synovitis have been developed and validated by several groups. The OMERACT criteria require that outcome measures demonstrate adequate validity, discriminative power, and feasibility if they are to be useful in clinical trials. Specific performance targets for these criteria depend on the scientific, regulatory, logistical, and financial context of the study in question. We review the extent to which MRI assessments of joint erosion, bone edema, and synovitis fulfil these criteria, particularly as they relate to proof-of-concept RA clinical trials.
authors.affiliation: Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK. philip.conaghan@leedsth.nhs.uk
authors.forename: Philip G
authors.initials: PG
authors.lastname: Conaghan
authors.forename: Fiona M
authors.initials: FM
authors.lastname: McQueen
authors.forename: Charles G
authors.initials: CG
authors.lastname: Peterfy
authors.forename: Marissa N D
authors.initials: MN
authors.lastname: Lassere
authors.forename: Bo
authors.initials: B
authors.lastname: Ejbjerg
authors.forename: Paul
authors.initials: P
authors.lastname: Bird
authors.forename: Philip J
authors.initials: PJ
authors.lastname: O'Connor
authors.forename: Espen
authors.initials: E
authors.lastname: Haavardsholm
authors.forename: John P
authors.initials: JP
authors.lastname: Edmonds
authors.forename: Paul
authors.initials: P
authors.lastname: Emery
authors.forename: Harry K
authors.initials: HK
authors.lastname: Genant
authors.forename: Mikkel
authors.initials: M
authors.lastname: Ostergaard
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards; D017063:Outcome Assessment, Health Care; D015203:Reproducibility of Results