title: Plant microRNA: a small regulatory molecule with big impact.
abstract: MicroRNAs (miRNAs) are an abundant new class of non-coding approximately 20-24 nt small RNAs. To date, 872 miRNAs, belonging to 42 families, have been identified in 71 plant species by genetic screening, direct cloning after isolation of small RNAs, computational strategy, and expressed sequence tag (EST) analysis. Many plant miRNAs are evolutionarily conserved from species to species, some from angiosperms to mosses. miRNAs may originate from inverted duplications of target gene sequences in plants. Although miRNA precursors display high variability, their mature sequences display extensive sequence complementarity to their target mRNA sequences. miRNAs play important roles in plant post-transcriptional gene regulation by targeting mRNAs for cleavage or repressing translation. miRNAs are involved in plant development, signal transduction, protein degradation, response to environmental stress and pathogen invasion, and regulate their own biogenesis. miRNAs regulate the expression of many important genes; a majority of these genes are transcriptional factors.
authors.affiliation: The Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech. University, Lubbock, 79409-1163, USA. baohong.zhang@ttu.edu
authors.forename: Baohong
authors.initials: B
authors.lastname: Zhang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.forename: George P
authors.initials: GP
authors.lastname: Cobb
authors.forename: Todd A
authors.initials: TA
authors.lastname: Anderson
mesh_terms: D018506:Gene Expression Regulation, Plant; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D063245:Plant Development; D010944:Plants / Q000235:genetics; D018749:RNA, Plant / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
chemical_list: D035683:MicroRNAs; D018749:RNA, Plant