title: Model of calcium oscillations due to negative feedback in olfactory cilia.
abstract: We present a mathematical model for calcium oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.
authors.affiliation: Institute of Applied Mathematics, University of Heidelberg, and WIN-Research Group of Olfactory Dynamics, Heidelberg Academy of Science and Humanities, Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Reidl
authors.forename: P
authors.initials: P
authors.lastname: Borowski
authors.forename: A
authors.initials: A
authors.lastname: Sensse
authors.forename: J
authors.initials: J
authors.lastname: Starke
authors.forename: M
authors.initials: M
authors.lastname: Zapotocky
authors.forename: M
authors.initials: M
authors.lastname: Eiswirth
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology; D002923:Cilia / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D009475:Neurons, Afferent / Q000502:physiology*; D009712:Nucleotides, Cyclic / Q000502:physiology; D009830:Olfactory Bulb / Q000502:physiology*
chemical_list: D002147:Calmodulin; D009712:Nucleotides, Cyclic; D002118:Calcium