title: Targeting the stromal fibroblasts: a novel approach to melanoma therapy.
abstract: Classically, cancer is thought of as a genetic disease, where the step-wise acquisition of mutations initiates and drives progression. More recent thinking posits that, although cancers are initiated through genetic mutation, progression is often the result of dynamic interactions between the tumor cells and their surrounding environment.
authors.affiliation: The Wistar Institute, Philadelphia, PA 19104, USA. ksmalley@wistar.org
authors.forename: Keiran S M
authors.initials: KS
authors.lastname: Smalley
authors.forename: Mercedes
authors.initials: M
authors.lastname: Lioni
authors.forename: Meenhard
authors.initials: M
authors.lastname: Herlyn
mesh_terms: D002448:Cell Adhesion; D002450:Cell Communication; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D015603:Keratinocytes / Q000502:physiology*; D008545:Melanoma / Q000276:immunology* / Q000628:therapy*; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic; D010641:Phenotype; D012878:Skin Neoplasms / Q000276:immunology* / Q000628:therapy*; D017154:Stromal Cells; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D016212:Transforming Growth Factor beta