title: Solitary bile duct hamartoma of the liver.
abstract: Bile duct hamartomas, also known as von Meyenburg complexes, are benign liver malformations which usually present as multiple small nodules scattered in both lobes of the liver. We report a unique case of bile duct hamartoma. An asymptomatic 30-year-old man who had a solitary cystic lesion underwent partial hepatectomy. Macroscopically, the lesion, measuring 3.6 cm in diameter, was composed of a number of small grayish-white cysts measuring 0.1 to 1.2 cm in diameter. Histologically, the constituent cysts were embedded in a fibrous stroma and were lined by low columnar or cuboidal epithelium. By immunohistochemistry, the MIB-1 index was below 1%, and p53 and carcinoembryonic antigen (CEA) were negative. These findings lead us to conjecture that the lesion was a bile duct hamartoma, although its solitary nature and large size differed from those of typical bile duct hamartoma.
authors.affiliation: Surgery Division, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa City, Chiba 277-8577, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hasebe
authors.forename: Masaru
authors.initials: M
authors.lastname: Konishi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagohri
authors.forename: Naoto
authors.initials: N
authors.lastname: Gotohda
authors.forename: Taira
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006222:Hamartoma / Q000175:diagnosis* / Q000601:surgery; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D007813:Laparotomy / Q000379:methods; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D018570:Risk Assessment; D016896:Treatment Outcome