title: Does the interval between prostate biopsy and radical prostatectomy affect the immediate postoperative outcome?
abstract: OBJECTIVE
  To determine whether the interval between prostate biopsy and radical prostatectomy (RP) affects the immediate postoperative outcome.
  
  
  METHODS
  The study was a retrospective chart review of 169 patients who had retropubic RP at our institution. Using a series of univariate and multivariate logistic regression analyses, we evaluated whether the interval between biopsy and RP was a significant independent predictor of operative duration, estimated blood loss, transfusion rate, nerve-sparing (yes/no), positive margin rate, length of stay, complications, and urinary continence after RP.
  
  
  RESULTS
  The interval from biopsy to RP was 14-378 days; there were no significant differences in operative duration, estimated intraoperative blood loss, nerve-sparing rate, transfusion rate and amount, hospitalization time, positive margin rate, major postoperative complications, and continence in patients with biopsy to RP intervals above and below the median. The biopsy to RP interval was not an independent predictor of outcomes during or after RP. There were no direct or indirect correlations between biopsy to RP interval and any of the postoperative outcomes.
  
  
  CONCLUSIONS
  The interval between prostate biopsy and retropubic RP appears to have no effect on immediate postoperative outcomes. We were unable to determine a specific minimum required interval beyond 2 weeks after prostate biopsy before proceeding with RP.
authors.affiliation: Department of Urology, University of Iowa, Iowa City, IA, USA.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Lee
authors.forename: Veerasuthpursh
authors.initials: V
authors.lastname: Allareddy
authors.forename: Michael A
authors.initials: MA
authors.lastname: O'donnell
authors.forename: Richard D
authors.initials: RD
authors.lastname: Williams
authors.forename: Badrinath R
authors.initials: BR
authors.lastname: Konety
mesh_terms: D000368:Aged; D001706:Biopsy / Q000706:statistics & numerical data; D001803:Blood Transfusion; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000209:etiology
chemical_list: D017430:Prostate-Specific Antigen