Biomarkers in acute coronary syndromes and their role in diabetic patients.
Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging. Regularly, diabetic patients have a less typical clinical presentation, which could lead to delayed diagnosis and subsequent delayed initiation of treatment. Since diabetic patients derive particular benefit from aggressive anti-platelet therapy, early diagnostic and therapeutic risk stratification of these patients is of critical importance to improve their adverse outcome. Although the electrocardiogram remains a pivotal diagnostic tool in the evaluation of patients suspected of having an acute coronary syndrome, only significant ST-segment changes provide reasonable prognostic information. Therefore, repeated assessment of circulating protein biomarkers represents a valuable diagnostic tool for improving efficacy and safety of decision-making in these patients. The combined use of biomarkers reflecting distinct pathophysiological aspects, such as myocardial necrosis, vascular inflammation, oxidative stress and neurohumoral activation, may significantly improve triage of patients with chest pain. These tools may identify those patients that are at particularly high risk for short-term and/or long-term cardiovascular events. Eventually, tailored medical and interventional treatment of diabetic patients should help to prevent these cardiac events in a cost-effective manner.
Heeschen
Christopher
C
Experimental Surgery, Department of Surgery, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany. christopher.heeschen@med.uni.muenchen.de
D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D048909:Diabetes Complications / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood; D012307:Risk Factors; D013577:Syndrome; D014336:Troponin / Q000097:blood
D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D014336:Troponin; D000072483:Placenta Growth Factor; D002097:C-Reactive Protein