title: Changing the metabolic profile by large-volume liposuction: a clinical study conducted with 123 obese women.
abstract: Adipose tissue is a metabolically active tissue. The hypertrophic fat cells of obese patients produce increased quantities of leptin and tumor necrosis factor-alpha (TNF-alpha) and are less sensitive to insulin. This study aimed to determine whether aspirating large amounts of these subcutaneous fat cells by large-volume liposuction (LVL), could change the metabolic profile in 123 obese women. All the patients had a main central body fat distribution (waist-hip ratio, 0.91+/-0.01) and a body mass index of 32.8 +/- 0.8 kg/m). They were studied for 90 days after LVL to determine their changes in insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. During 3 months of follow-up evaluation, LVL resulted in a significantly improved insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. Such parameters correlate with a decrease in fat mass and waist-hip ratio. Interestingly, no significant changes were seen between the first (21 days) and second (90 days) metabolic determinations after LVL. However, these findings, confirm other preliminary data published previously, and could change the actual role of LVL in the multidisciplinary treatment of obesity.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Second University of Naples, VIA L. Decrecchio 4, 80100 Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Andrea
authors.forename: Roberto
authors.initials: R
authors.lastname: Grella
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Rizzo
authors.forename: Elisa
authors.initials: E
authors.lastname: Grella
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Grella
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Nicoletti
authors.forename: Michelangela
authors.initials: M
authors.lastname: Barbieri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000328:Adult; D000886:Anthropometry; D001481:Basal Metabolism; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism / Q000473:pathology; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D015187:Lipectomy / Q000379:methods*; D009765:Obesity / Q000378:metabolism* / Q000601:surgery*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha