Measuring injury and repair of myelin and neurons in multiple sclerosis.
Neuroprotection in MS needs to be considered in the context of several pathological processes: limitation of acute inflammatory injury to myelin and axons, remyelination, survival of demyelinated axons, and limitation of more diffuse, nonlesional pathology that affects myelin and axons. Advanced MRI techniques are capable of reporting on all of these different pathological features of MS and will be an important aspect of the assessment of neuroprotection strategies in MS, when these become available.
Arnold
D L
DL
Montreal Neurological Institute, McGill University, Quebec, Canada. doug@mrs.mmi.mcgill.ca
Chen
J
J
D000818:Animals; D015415:Biomarkers; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D009186:Myelin Sheath / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D011522:Protons; D013053:Spectrophotometry; D014867:Water; D014945:Wound Healing
D015415:Biomarkers; D011522:Protons; D014867:Water