Effects of topical sesame oil on oxidative stress in rats.
OBJECTIVE
To assess the effects of topical sesame oil on systemic oxidative stress in rats.


METHODS
Oxidative stress was induced with lipopolysaccharide and assessed by determining serum lipid peroxidation, superoxide anion, and hydroxyl radical levels. The levels of 3 circulating antioxidants--superoxide dismutase, catalase, and glutathione--also were determined.


RESULTS
Topical sesame oil significantly reduced lipid peroxidation, superoxide anion, and hydroxyl radical levels after lipopolysaccharide administration. However, sesame oil did not affect the 3 circulating antioxidants. Further, sesame oil decreased the activity of xanthine oxidase and nitric oxide production in lipopolysaccharide-treated rats.


CONCLUSIONS
Sesame oil given topically might attenuate oxidative stress by inhibiting the production of xanthine oxidase and nitric oxide in rats.
Chiang
James Po-Jung
JP
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan.
Hsu
Dur-Zong
DZ
Tsai
Jui-Chen
JC
Sheu
Hamm-Ming
HM
Liu
Ming-Yie
MY
D000818:Animals; D002374:Catalase / Q000032:analysis / Q000187:drug effects; D004195:Disease Models, Animal; D005978:Glutathione / Q000032:analysis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008070:Lipopolysaccharides; D008163:Luminescent Measurements; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011336:Probability; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000032:analysis* / Q000378:metabolism; D012680:Sensitivity and Specificity; D012715:Sesame Oil / Q000008:administration & dosage / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000032:analysis / Q000187:drug effects
D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species; D012715:Sesame Oil; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione