title: Angiogenesis in the mouse retina: a model system for experimental manipulation.
abstract: The vascular system of the mouse retina provides a useful model for analyzing the molecular and cellular mechanisms regulating angiogenesis because (1) hierarchical vascular networks are newly formed only after birth, (2) the cellular components involved in angiogenesis are well characterized, and (3) all the processes are accessible for monitoring and manipulation. In this article, we present an overview of our current understanding of the process of retinal angiogenesis and describe a number of methodologies applicable to experimental manipulation of the retinal vascular system.
authors.affiliation: Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, 2-2-3 Minatojima Minamimachi, Kobe 650-0047, Japan. auemura@cdb.riken.jp
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Uemura
authors.forename: Sentaro
authors.initials: S
authors.lastname: Kusuhara
authors.forename: Hideto
authors.initials: H
authors.lastname: Katsuta
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Nishikawa
mesh_terms: D000818:Animals; D051379:Mice; D023421:Models, Animal; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D012171:Retinal Vessels / Q000502:physiology*