title: Cusp tear in bicuspid aortic valve possibly caused by phentermine.
abstract: A 28 year old woman underwent echocardiography following an incidental finding of a diastolic murmur. She has been taking phentermine for weight reduction for 8 months. Trans-esophageal echocardiography revealed a tear of the posterior cusp of the aortic valve causing severe regurgitation. Phentermine is known to cause valvular disease with prolonged use, but aortic valve rupture was not previously reported as a complication of phentermine valvulopathy.
authors.affiliation: Cardiac Ultrasound Laboratory, VBK508 Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA. cyosefy@partners.org
authors.forename: Chaim
authors.initials: C
authors.lastname: Yosefy
authors.forename: Michael
authors.initials: M
authors.lastname: Berman
authors.forename: Ronen
authors.initials: R
authors.lastname: Beeri
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000187:drug effects*; D001067:Appetite Depressants / Q000009:adverse effects*; D017548:Echocardiography, Transesophageal; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D010645:Phentermine / Q000009:adverse effects*
chemical_list: D001067:Appetite Depressants; D010645:Phentermine