Total synthesis, NMR solution structure, and binding model of the potent histone deacetylase inhibitor FR235222.
Rodriquez
Manuela
M
Dipartimento Farmaco Chimico Tecnologico, Università di Siena via A. Moro 2, 53100 Siena, Italy.
Terracciano
Stefania
S
Cini
Elena
E
Settembrini
Giulia
G
Bruno
Ines
I
Bifulco
Giuseppe
G
Taddei
Maurizio
M
Gomez-Paloma
Luigi
L
D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; C474179:FR 235222; D056572:Histone Deacetylase Inhibitors; D010456:Peptides, Cyclic; D012996:Solutions; D006655:Histone Deacetylases