title: Mismatch negativity (MMN) in multiple sclerosis: an event-related potentials study in 46 patients.
abstract: OBJECTIVE
  To assess pre-attentive detection mechanisms indexed by MMN component of auditory Event-Related Potentials (ERPs) in Multiple Sclerosis (MS) patients.
  
  
  METHODS
  46 MS patients (mean age 43.7 years, mean disease duration 10.1 years, mean EDSS 4.6) and 46 matched controls were assessed with ERPs elicited by a passive oddball paradigm using duration deviants. Auditory P50, N1, P2 components were recorded. MMN and P3a components were calculated as the difference potential between deviants and standard stimuli. Eighteen of these 46 patients underwent also global psychometrical assessment and were sorted in cognitively normal and impaired patients. ERPs of these two groups of patients were compared.
  
  
  RESULTS
  MS patients showed reduced MMN and P3a areas as compared to controls, besides exogenous N1-P2 complex amplitude reduction. Among the 18 patients investigated with neuropsychological testings, six were cognitively impaired and 12 cognitively unimpaired. Patients with a global cognitive impairment had reduced MMN as compared to cognitively unimpaired patients.
  
  
  CONCLUSIONS
  Auditory MMN and P3a components of auditory ERPs are altered in MS patients. MMN alterations are more pronounced in cognitively impaired patients.
  
  
  CONCLUSIONS
  MMN and P3a areas reduction suggests that MS patients are prone to pre-attentive auditory information processing deficits, besides previously described controlled information processing difficulties. Moreover, MMN alterations may represent an objective index of cognitive disturbances in MS patients.
authors.affiliation: Department of Clinical Neurophysiology, Hopital Neurologique, Lyon, France. jung@lyon.inserm.fr
authors.forename: Julien
authors.initials: J
authors.lastname: Jung
authors.forename: Dominique
authors.initials: D
authors.lastname: Morlet
authors.forename: Bernadette
authors.initials: B
authors.lastname: Mercier
authors.forename: Christian
authors.initials: C
authors.lastname: Confavreux
authors.forename: Catherine
authors.initials: C
authors.lastname: Fischer
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000209:etiology; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011594:Psychometrics / Q000379:methods; D011930:Reaction Time