title: Biliodigestive anastomosis after intraoperative irradiation in swine.
abstract: A large animal model was established to investigate the feasibility and suitable dosage of intraoperative radiation therapy (IORT) to the hepatic hilum before biliary-enteric anastomosis is performed. Twenty-two Pietrain Hampshire pigs underwent gallbladder and proximal bile duct resection followed by IORT using 20-40 Gy and performing biliary-enteric anastomosis. In the follow-up period of 56 days, pigs developed dose-dependent complications like stenosis of the biliary-enteric anastomosis. Results demonstrate that IORT of the liver hilum up to 20 Gy is safe with acceptable early complications in the presented animal model. The porcine biliary-enteric anastomosis can tolerate intraoperative irradiation up to a dosage of 40 Gy without disruption.
authors.affiliation: Department of General Surgery and Transplantation, University Hospital Essen, Essen, Germany. gernot.kaiser@uni-essen.de
authors.forename: G M
authors.initials: GM
authors.lastname: Kaiser
authors.forename: A B
authors.initials: AB
authors.lastname: Mueller
authors.forename: W
authors.initials: W
authors.lastname: Sauerwein
authors.forename: H W
authors.initials: HW
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Westermann
authors.forename: N R
authors.initials: NR
authors.lastname: Frühauf
authors.forename: C A
authors.initials: CA
authors.lastname: Kuehne
authors.forename: M
authors.initials: M
authors.lastname: Stuschke
authors.forename: K J
authors.initials: KJ
authors.lastname: Oldhafer
authors.forename: C E
authors.initials: CE
authors.lastname: Broelsch
mesh_terms: D000713:Anastomosis, Roux-en-Y / Q000009:adverse effects; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001918:Brachytherapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006500:Hepatic Duct, Common / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery*; D007430:Intraoperative Care; D007583:Jejunum / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery*; D008099:Liver / Q000201:enzymology; D008279:Magnetic Resonance Imaging; D011183:Postoperative Complications / Q000662:veterinary; D013552:Swine
chemical_list: D001663:Bilirubin