Mouse Ubc9 knockout: many path(way)s to ruin.
In this issue of Developmental Cell, Nacerddine et al. (2005) describe a targeted germ line mutation of the mouse SUMO-specific E2 Ubc9, which abrogates the SUMO conjugation pathway, broadly crippling nuclear function in proliferating cells of the early embryo. This study reveals the wide-ranging roles for this protein modifier in nuclear organization, chromosome segregation, and Ran-driven nucleo-cytoplasmic transport.
Kuehn
Michael R
MR
Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702, USA.
D000818:Animals; D017209:Apoptosis; D001755:Blastocyst / Q000201:enzymology; D004622:Embryo, Mammalian / Q000166:cytology*; D051379:Mice; D018345:Mice, Knockout; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D044763:Ubiquitin-Conjugating Enzymes / Q000502:physiology*; D000098843:Ubiquitin-Conjugating Enzyme UBC9
D025841:Small Ubiquitin-Related Modifier Proteins; D044763:Ubiquitin-Conjugating Enzymes; D000098843:Ubiquitin-Conjugating Enzyme UBC9