title: Meroditerpenoids from a Formosan soft coral Nephthea chabrolii.
abstract: Eight new meroditerpenoid-related metabolites, including one naphthoquinone derivative, chabrolonaphthoquinone B (1), four tetraprenyltoluquinone-related compounds, chabrolobenzoquinones E-H (2-5), and three tetraprenyltoluquinol-related metabolites, chabrolohydroxybenzoquinones E-G (6-8), were isolated from the organic extract of a Taiwanese soft coral Nephthea chabrolii. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of the related metabolites. Cytotoxic activity of metabolites 1-3 and 5-8 against a limited panel of cancer cell lines is also described.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D016227:Benzoquinones; D004224:Diterpenes; D009285:Naphthoquinones; C506491:chabrolonaphthoquinone B