[Antitumor effects of intratumoral injection of Basidiomycetes preparations].
The antitumor effects of Basidiomycetes preparations in an experimental mouse model, the "double grafted tumor system" were analyzed. Some BRMs prevented metastases by utilizing the anti-tumor immunological cascade reactions, which activates macrophages in the body. The following Basidiomycetes preparations were analyzed: PSK was a hot water extract of cultured mycelia from Coliolus versicolor and a protein bound beta-glucan. Matsumax was extracted from mycelia of Tricholoma matsutake and was a protein bound (38%) a-glucan. The Agaricus preparation was extracted from fruit bodies of Agaricus blazei and a protein-bound (17%) a-glucan, beta-glucan. Himematsutake preparation was extracted from fruit body of Agaricus blazei (Himematsutake) and a protein bound (5%) glucan. Lentinan was purified from fruit bodies of Lentinus edodes and is a purified beta-glucan. PSK cured both primary and metastatic tumors in the double grafted tumor system. Lentinan inhibited the growth of neither primary nor metastatic tumors. Matsumax and Agaricus preparation cured primary tumor and inhibited the growth of metastatic tumor. Himematsutake preparation inhibited the growth of primary tumor. Immunosuppresive acidic protein (IAP) is produced by activated mactrophates. The PSK, Matsumax, Agaricus preparation and Himematsutake preparation induced IAP but Lentinan did not.
Ebina
Takusaburo
T
Division of Immunology, Miyagi Cancer Center Research Institute.
D000364:Agaricus / Q000737:chemistry; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D001487:Basidiomycota / Q000737:chemistry*; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000494:pharmacology; D015552:Injections, Intralesional; D007912:Lentinan / Q000008:administration & dosage / Q000494:pharmacology; D008262:Macrophage Activation / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009363:Neoplasm Proteins / Q000097:blood; D009374:Neoplasms, Experimental / Q000276:immunology*; D018514:Plant Structures; D011485:Protein Binding; D011509:Proteoglycans / Q000008:administration & dosage / Q000494:pharmacology; D047071:beta-Glucans / Q000008:administration & dosage / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D007155:Immunologic Factors; D009363:Neoplasm Proteins; D011509:Proteoglycans; D047071:beta-Glucans; C030193:immunosuppressive acidic protein; D007912:Lentinan; C010770:polysaccharide-K