title: Training does not affect the alteration in pulmonary artery vasoreactivity in pulmonary hypertensive rats.
abstract: This study examined the effects of training on intrinsic vasorelaxation and vasoconstriction properties of pulmonary hypertensive rat arteries. Fifty seven male Wistar rats were randomly assigned to 4 groups: normotensive sedentary (n = 14), normotensive trained (n = 15), pulmonary hypertensive sedentary (n = 15) and pulmonary hypertensive trained (n = 13). Pulmonary hypertension was obtained using a chronic hypoxia exposure model. Endothelium-dependent vasorelaxation to acetylcholine (10(-8)-10(-4) M), endothelium-independent vasorelaxation to sodium nitro-prusside (10(-8)-10(-4) M), and vasoconstriction to epinephrine (10(-9)-10(-4) M) and endothelin-1 (10(-12)-10(-7) M) were assessed on isolated rings of large pulmonary arteries. Alterations in endothelium-dependent and -independent vasorelaxation properties as well as enhanced vasoconstrictor responses were obtained in pulmonary hypertensive rats. Chronic exercise did not affect those pulmonary vasoreactivity alterations. A predominant effect of chronic hypoxia over training seems to be partially responsible for this phenomenon, probably through impairment in nitric oxide bioavailability and vascular smooth muscle sensitivity.
authors.affiliation: EA2992, Dynamique des Incohérences Cardio-Vasculaires, Faculté de Médecine de Nîmes, Montpellier, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Goret
authors.forename: Cyril
authors.initials: C
authors.lastname: Reboul
authors.forename: Stephane
authors.initials: S
authors.lastname: Tanguy
authors.forename: Michel
authors.initials: M
authors.lastname: Dauzat
authors.forename: Philippe
authors.initials: P
authors.lastname: Obert
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D011651:Pulmonary Artery / Q000503:physiopathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D019332:Endothelin-1; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D011189:Potassium Chloride; D000109:Acetylcholine; D004837:Epinephrine