title: Reliability of quantitative and qualitative tests to identify heterozygotes carrying severe or mild G6PD deficiency.
abstract: OBJECTIVE
  To determine if the qualitative test (cytochemical) is more reliable than the quantitative test (differential pH-metry) in identifying heterozygous G6PD- subjects.
  
  
  METHODS
  Identification of heterozygous G6PD- subjects was done by the measurement of G6PD activity and by a cytochemical test.
  
  
  RESULTS
  A cytochemical test is more sensitive than differential pH-metry to identify heterozygous G6PD- subjects.
  
  
  CONCLUSIONS
  A cytochemical test is a reliable method for mass screening for G6PD deficiency to identify G6PD- heterozygotes.
authors.affiliation: Istituto di Scienze Neurologiche-CNR, Contrada Burga, 87050 Mangone, Cosenza, Italy. a.tagarelli@isn.cnr.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Tagarelli
authors.forename: Anna
authors.initials: A
authors.lastname: Piro
authors.forename: Loredana
authors.initials: L
authors.lastname: Bastone
authors.forename: Francesca
authors.initials: F
authors.lastname: Condino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tagarelli
mesh_terms: D000328:Adult; D004906:Erythrocyte Count; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007558:Italy; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012680:Sensitivity and Specificity; D044465:White People
chemical_list: D005954:Glucosephosphate Dehydrogenase