Revealing the genomic heterogeneity of melanoma.
The melanoma genome possesses numerous recurrent chromosomal rearrangements, and embedded within this complexity are clues critical to disease pathogenesis and response to therapy. High-resolution genome-wide DNA copy number approaches, in conjunction with gene-specific mutational analyses, appear poised to define keystone molecular events, provide more accurate classification schemes, and set the stage for the design of rational therapies that may finally have an impact on survival of this deadly disease.
Kabbarah
Omar
O
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Chin
Lynda
L
D017398:Alternative Splicing; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics / Q000528:radiation effects; D004252:DNA Mutational Analysis / Q000379:methods; D018628:Gene Dosage; D018740:Genetic Heterogeneity; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000628:therapy