Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin.
Parvovirus B19-infected hydrops fetalis was treated using gammaglobulin injection into the peritoneal cavity (GIFPeC) with B19-IgG-rich immunoglobulin. Fetal anemia and hydrops resolved, and B19-DNA in fetal ascites decreased despite no change in maternal B19-IgG or B19-DNA. Gammaglobulin injection into the peritoneal cavity is thus useful for treating hydrops fetalis while avoiding intrauterine blood-transfusion risks.
Matsuda
Hideo
H
Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama Prefecture, Japan. hmatsuda@ndmc.ac.jp
Sakaguchi
Kenichiro
K
Shibasaki
Tomoko
T
Takahashi
Hironori
H
Kawakami
Yuichi
Y
Furuya
Kenichi
K
D000328:Adult; D000740:Anemia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000627:therapeutic use; D016731:Erythema Infectiosum / Q000150:complications / Q000151:congenital* / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use; D007231:Infant, Newborn; D007274:Injections, Intraperitoneal; D008297:Male; D016732:Parvovirus B19, Human / Q000276:immunology / Q000472:pathogenicity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis; D011296:Prenatal Diagnosis; D005719:gamma-Globulins / Q000008:administration & dosage / Q000627:therapeutic use*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D005719:gamma-Globulins