title: Survival of biphasic pulmonary blastoma.
abstract: Pulmonary blastoma is a rare malignant lung tumor with a poor prognosis. It is composed of immature mesenchymal and epithelial components that resemble fetal lung tissue. We aimed to share our treatment results in biphasic pulmonary blastoma. In Ataturk Chest Disease and Thoracic Surgery Center, five patients with biphasic pulmonary blastoma (four men, one woman, aged between 27 and 61-mean 39.4) were treated between 1987 and 2000 (0.3% of operated NSCC). Hemoptysis, cough, chest pain and dyspnea were the symptoms. Anemia and high erythrocyte sedimentation rate were determined in two patients. Radiological examinations revealed a mass in four patients and massive pleural effusion in one. None of the patients were diagnosed preoperatively and hence all patients underwent exploratory thoracotomy. Three lobectomy, one pneumonectomy and one wedge resection were performed. Histopathological examinations revealed biphasic pulmonary blastoma in all the patients. Pathological stagings were as follows: 1 patient in T1N0M0 and 1 patient in T2N0M0 (198 and 112 months survival, respectively), three patients in T2N1M0 (9,10,17 months survival). In follow up period, prostate carcinoma and rectum carcinoma were detected as second primary tumors in the patient in stage T2N0M0. In patients who have small size tumors without nodal involvement, long-term survival can be obtained with radical surgery; even in biphasic pulmonary blastomas. According to our limited experiences, N1 nodal involvement shows very poor prognosis.
authors.affiliation: Thoracic Surgery Department, The Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. tubaliman@kou.edu.tr
authors.forename: Serife Tuba
authors.initials: ST
authors.lastname: Liman
authors.forename: Tamer
authors.initials: T
authors.lastname: Altinok
authors.forename: Salih
authors.initials: S
authors.lastname: Topcu
authors.forename: Abdullah Irfan
authors.initials: AI
authors.lastname: Tastepe
authors.forename: Ali
authors.initials: A
authors.lastname: Uzar
authors.forename: Sedat
authors.initials: S
authors.lastname: Demircan
authors.forename: Funda
authors.initials: F
authors.lastname: Demirag
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018202:Pulmonary Blastoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome