title: Paratumoral epidermal hyperplasia: a novel prognostic factor in thick primary melanoma of the skin?
abstract: There is a lack of histopathological factors to sub-stratify prognosis in pT3/4 melanoma primaries. In the presented pilot study, the prognostic significance of different clinical and histopathological parameters was studied in thick primary melanoma taking paratumoral epidermal hyperplasia (PTEH) into consideration. Of 1632 melanoma patients in the melanoma register of the Martin Luther University Halle-Wittenberg in the years 1980 to 1987, 16 cases with tumor thickness (TT) of the primary > or = 3 mm, documented metastasis-free follow-up of 10+ years after primary therapy and available histologic sections were compared with an adequate recurrence control group (n = 62) by PTEH and standard prognostic parameters. PTEH was demonstrable in 15 of 16 patients of the metastasis-free group (PTEH penetration depth 1.42 +/- 0.82 mm/mean +/- SD) and 27 of 62 of controls (0.29 +/- 0.46 mm), P < or = 0.001. Of the standard prognostic parameters, TT, sex, location, and lack of nevus association also correlated with metastasis. In multivariate analysis, PTEH > or = 1 mm was the single independent parameter with the highest (negative) association to recurrence (odds ratio 52.3). Occurrence of PTEH might predict a more moderate course of disease in thick melanoma. Thus, it might become an easily determinable and effective tool to sub-stratify prognosis in thick primary melanoma of the skin. Further studies are necessary to prove these findings.
authors.affiliation: Department of Dermatology, Martin Luther University, Halle-Wittenberg, Halle (Saale), Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Drunkenmölle
authors.forename: Wolfgang Ch
authors.initials: WCh
authors.lastname: Marsch
authors.forename: Dieter
authors.initials: D
authors.lastname: Lübbe
authors.forename: Peter
authors.initials: P
authors.lastname: Helmbold
mesh_terms: D000328:Adult; D000368:Aged; D004817:Epidermis / Q000473:pathology*; D066246:ErbB Receptors / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D010865:Pilot Projects; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D066246:ErbB Receptors