title: Development of contrast enhancement after long-term observation of a dysembryoplastic neuroepithelial tumor.
abstract: Dysembryoplastic neuroepithelial tumors (DNET) are usually benign lesions that arise in cortical regions and are discovered after new onset of seizure. These lesions have many different imaging characteristics. We report a patient with a presumed low-grade medial temporal lobe lesion that was followed for many years without any change in size or imaging characteristics. This previously non-enhancing tumor evolved to become contrast enhanced on routine imaging without apparent tumor growth. The patient underwent surgery, and the pathology was confirmed as a DNET with no atypical changes. This case demonstrates the potential that DNETs may exhibit a changing MRI pattern over time. Natural history, imaging characteristics, and management are reviewed.
authors.affiliation: Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132-2303, USA. randy.jensen@hsc.utah.edu
authors.forename: Randy L
authors.initials: RL
authors.lastname: Jensen
authors.forename: Eryn
authors.initials: E
authors.lastname: Caamano
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Jensen
authors.forename: William T
authors.initials: WT
authors.lastname: Couldwell
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D011856:Radiographic Image Enhancement; D012640:Seizures / Q000209:etiology
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media; D005682:Gadolinium