[Effect of acute coronary microembolization on microvascular injury and myocardial endothelin-1 levels].
To investigate the effect of coronary microemboliation (CME) on coronary microvascular injury and myocardial endothelin-1 (ET-1) level.



CME was induced in 10 miniswines by selective infusion of microspheres (45 microm) into left anterior descending artery (LAD). The ET-1 level in coronary sinus was measured with radioimmunoassay. The microvascular integrity indicator CFR was measured by Doppler flow wire in LAD at baseline and after infusion of microspheres.



Compared to the baseline, CFR decreased significantly with different doses of microspheres. ET-1 level increased significantly with doses of 5 x 10(4) and peaked with 10 x 10(4), and progressively decreased from doses of 12 x 10(4) to 15 x 10(4) microspheres. There was negative correlation between ET-1 and CFR (r=-0.31, P=0.02).



The extent of microvascular injury is not linearly related to the extent of microembolization, but it is closely associated with myocardial ET-1 level.
Zhang
Qing-yong
QY
Department of Cardiology, The First Affiliate Hospital, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Ge
Jun-bo
JB
Zhu
Jian-hua
JH
Zhang
Qing-gang
QG
Zhang
Liang-hui
LH
Qian
Ju-ying
JY
Chen
Jun-zhu
JZ
D000818:Animals; D003331:Coronary Vessels / Q000473:pathology*; D004195:Disease Models, Animal; D004617:Embolism; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology; D013552:Swine; D013556:Swine, Miniature
D019332:Endothelin-1