Regulatory T cells in psoriasis.
Psoriasis is a chronic autoimmune disease in which T lymphocytes are thought to be central in the pathogenesis. Recently, a T cell subset population was identified, whose role is to suppress inflammatory responses triggered by T effector cells. T cells in this new population are referred to as T regulatory cells. We studied their number and activity in psoriatic lesions and found that they are both numerically and functionally deficient in their ability to suppress the abnormally persistent psoriatic immune response. This deficiency may shed more light on the complex pathophysiology of psoriasis.
Kagen
M H
MH
McCormick
T S
TS
Cooper
K D
KD
D000077944:Alefacept; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D011993:Recombinant Fusion Proteins / Q000276:immunology / Q000627:therapeutic use; D012867:Skin / Q000166:cytology / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D011993:Recombinant Fusion Proteins; D000077944:Alefacept