[Preparation and investigation of gemfibrozil + dimethyl-beta-cyclodextrin products and solid dosage forms].
Gemfibrozil is a lipid-regulating active substance. Dimethyl-beta-cyclodextrin products were prepared from this sparingly soluble pharmacon by means of methods such as physical mixing, kneading, spray drying and ultrasonication. Solid dosage forms (hydroxypropylmethyl cellulose /HPMC/ capsules and tablets) were prepared from the selected products on the basis of their dissolution profile and the in vitro membrane diffusion results. This publication details the results of electronmicroscopic morphological studies, particle size analysis and wetting contact angle determinations, and also the preparation and examination of the resulting solid dosage forms.
Hassan
Bin Hassan
BH
Szegedi Tudományegyetem, Gyógyszer-technológiai Intézet, Szeged, Eötvös u. 6. - 6720.
Aigner
Zoltán
Z
Kása
Péter
P
Hódi
Klára
K
Eros
István
I
D004058:Diffusion; D004304:Dosage Forms; D015248:Gemfibrozil / Q000008:administration & dosage / Q000737:chemistry*; D008854:Microscopy, Electron; D012995:Solubility; D013607:Tablets; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004304:Dosage Forms; D013607:Tablets; D047392:beta-Cyclodextrins; D015248:Gemfibrozil