Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.
The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.
Mittal
S
S
Department of Clinical Haematology, Aberdeen Royal Infirmary, Aberdeen, UK. sajjanmittal@yahoo.com
Milner
B J
BJ
Vickers
M A
MA
D000328:Adult; D002999:Clone Cells / Q000473:pathology; D015329:Gene Rearrangement, T-Lymphocyte; D019674:Genes, T-Cell Receptor beta; D019675:Genes, T-Cell Receptor gamma; D006801:Humans; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000209:etiology; D013163:Splenomegaly / Q000209:etiology*; D013601:T-Lymphocytes / Q000473:pathology*