Acquired coagulation inhibitor-associated bleeding disorders: an update.
Acquired blood coagulation inhibitors are circulating immunoglobulins that neutralize the activity of a specific coagulation protein or accelerate its clearance from the plasma, thus causing a bleeding tendency. In this review, we focus on the nonhemophilic inhibitors of coagulation, i.e. the autoantibodies occurring in individuals without a pre-existent coagulation defect, reporting the most recent advances in the pathophysiology, diagnosis and treatment of these rare acquired bleeding disorders.
Franchini
Massimo
M
Servizio di Immunoematologia e Trasfusione--Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@mail.univr.it
Veneri
Dino
D
D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001778:Blood Coagulation Disorders / Q000097:blood / Q000276:immunology*; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors* / Q000276:immunology; D006467:Hemophilia A / Q000276:immunology; D006801:Humans
D001323:Autoantibodies; D001779:Blood Coagulation Factors