title: A comparison of wound treatments in nasopharyngeal cancer patients receiving radiation therapy.
abstract: The purpose of this study was to compare the effectiveness of gentian violet and nonadherent absorbent dressing in the healing of postirradiation wounds in nasopharyngeal carcinoma patients. This was a randomized controlled trial. A sample of 146 nasopharyngeal carcinoma patients who had developed postirradiation wounds was assessed. Comparisons were made regarding parameters related to wound healing, including healing time, presence of infection, and wound pain, and also regarding the impact of wound on the patient, including mood changes, restriction of neck movement, social isolation, sleep problem, and disturbance in body image. The results showed that patients in the 2 groups did not have any significant difference on wound-healing time, disturbance in mood, sleep, social interaction, appearance, and neck mobility. However, there was a trend of higher wound pain score, not reaching statistical significance, in the gentian violet group.
authors.affiliation: Department of Clinical Oncology, Prince of Wales Hospital, Shatin, NT, Hong Kong, SAR, China. s_mak@clo.cuhk.edu.hk
authors.forename: S S
authors.initials: SS
authors.lastname: Mak
authors.forename: C Y
authors.initials: CY
authors.lastname: Zee
authors.forename: A
authors.initials: A
authors.lastname: Molassiotis
authors.forename: S J
authors.initials: SJ
authors.lastname: Chan
authors.forename: S F
authors.initials: SF
authors.lastname: Leung
authors.forename: K F
authors.initials: KF
authors.lastname: Mo
authors.forename: P J
authors.initials: PJ
authors.lastname: Johnson
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001458:Bandages / Q000592:standards*; D019583:Dose Fractionation, Radiation; D005260:Female; D005840:Gentian Violet / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D015403:Nursing Evaluation Research; D010146:Pain / Q000175:diagnosis / Q000209:etiology; D010147:Pain Measurement; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011855:Radiodermatitis / Q000209:etiology / Q000451:nursing*; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D017592:Skin Care / Q000379:methods* / Q000451:nursing / Q000592:standards; D013997:Time Factors; D014945:Wound Healing
chemical_list: D000891:Anti-Infective Agents, Local; D005840:Gentian Violet