title: Adrenergic-mediated exposure of hyperkalemia in the electrocardiogram.
abstract: We document full exposure of the electrocardiographic hyperkalemia signs brought about by exogenous epinephrine in a patient on long-term beta-blockade treatment in whom spironolactone-induced hyperkalemia developed. We propose that the stimulated adrenergic receptor promoted re-expression of two main potassium channels (I(Kr), I(Ks)) involved in ventricular repolarization, modifying the ECG waveform. The effects of hyperkalemia could be aggravated in the presence of beta-adrenergic blockade.
authors.forename: Tomas
authors.initials: T
authors.lastname: Raviña
authors.forename: Paula
authors.initials: P
authors.lastname: Raviña
authors.forename: Manuela
authors.initials: M
authors.lastname: Raviña
mesh_terms: D000369:Aged, 80 and over; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D006947:Hyperkalemia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology
chemical_list: D015221:Potassium Channels; D011941:Receptors, Adrenergic