Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions.
Postoperative peritoneal adhesions are common, serious complications of general abdominal and gynecologic surgery that can lead to chronic abdominal pain, intestinal obstruction, and infertility. As yet, there are no ideal drugs that may be prescribed for patients to prevent adhesion formation effectively. In this study the effects of escin, a natural drug, on the various steps of adhesion formation were investigated. The effects of escin on increased vascular permeability induced by acetic acid in a mouse model of acute inflammation, granuloma formation in a subchronic inflammatory rat model, gastrointestinal transit in rats with intestinal paralysis, intestinal motility in postoperative patients, and postoperative adhesion formation in a rat model were observed. It was shown that escin could inhibit acute inflammation and granuloma formation, cause acceleration of gastrointestinal transit, help recover intestinal motility, and attenuate the formation of postoperative adhesions. The findings suggest that escin attenuates the formation of postoperative adhesions by inhibiting inflammation and promoting gastrointestinal transit. Thus it may be concluded that both inhibition of inflammation and increased gastrointestinal motility during the early postoperative period have a positive effect on decreasing the formation of adhesions.
Fu
Fenghua
F
Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, P.R., 264005, China. fufenghua@Sohu.com
Hou
Yuezhi
Y
Jiang
Wanglin
W
Wang
Ronghua
R
Liu
Ke
K
D000328:Adult; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D004195:Disease Models, Animal; D004928:Escin / Q000008:administration & dosage*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006099:Granuloma / Q000517:prevention & control; D006801:Humans; D045823:Ileus / Q000209:etiology / Q000517:prevention & control*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008875:Middle Aged; D011183:Postoperative Complications; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
D004928:Escin