Effect of statin use in patients with acute coronary syndromes and a serum low-density lipoprotein<or=80 mg/dl.
We identified 155 patients who were admitted with an acute coronary syndrome and a low-density lipoprotein cholesterol level<or=80 mg/dl and were not on statin therapy at hospital admission. The relation between statin therapy at discharge and clinical outcome was evaluated in these patients. Compared with patients who were not discharged on statins, those who were had a lower incidence of death, reinfarction, or stroke at 6 months (29.0% vs 9.5%, p=0.005). These results suggest that patients who have an acute coronary syndrome and a low-density lipoprotein cholesterol level<or=80 mg/dl in the absence of statin therapy may benefit from such therapy at discharge.
Tsai
Thomas T
TT
Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. hsianshi@umich.edu
Nallamothu
Brahmajee K
BK
Mukherjee
Debabrata
D
Rubenfire
Melvyn
M
Fang
Jianming
J
Chan
Paul
P
Kline-Rogers
Eva
E
Patel
Amisha
A
Armstrong
David F
DF
Eagle
Kim A
KA
Goldberg
A D
AD
D000208:Acute Disease; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood* / Q000187:drug effects; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D005500:Follow-Up Studies; D006801:Humans; D008824:Michigan / Q000453:epidemiology; D043803:Phenalenes / Q000627:therapeutic use*; D017035:Pravastatin / Q000627:therapeutic use*; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D015415:Biomarkers; D008078:Cholesterol, LDL; D043803:Phenalenes; C030462:atrovenetin; D017035:Pravastatin