The effects of individual amino acids on the fast folding dynamics of alpha-helical peptides.
Nanosecond temperature jump experiments coupled to time-resolved infrared spectroscopy were carried out on a series of alanine-based peptides containing different guest amino acids to study the effects of residues with different helix propensities on the helix-coil dynamics.
Gooding
Edward A
EA
Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA. egoodin1@swarthmore.edu
Ramajo
Angela Pozo
AP
Wang
JunWei
J
Palmer
Colin
C
Fouts
Elizabeth
E
Volk
Martin
M
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors
D000596:Amino Acids; D010455:Peptides