title: [Hodgkin disease of the nasopharynx: report of three cases].
abstract: We report three cases of Hodgkin's disease (HD) involving the nasopharynx. Their clinical presentations, morphological and immunohistochimical features and their therapy modalities are discussed. The patients were aged 36, 41 and 77, presenting with increasing bilateral nasal obstruction in one case and a cervical mass in the two others. Histological study showed mixed cellularity type of HD in all cases. The Reed Sternberg cells expressed both of CD15 and CD30 in one case, and only one of them in the other cases. In one case, LMP1 was detected, CD20 and CD3 were not. HD of nasopharynx should be differentiated from EBV-associated lymphoproliferations. The treatment is based on radiotherapy that can be associated to neoadjuvant chemotherapy if nodes are involved.
authors.affiliation: Service de radiothérapie carcinologique, institut Salah-Azaïz, boulevard 9-avril, Bab-Saadoun, 1006 Tunis, Tunisie. lotfi.kochbati@rns.tn
authors.forename: L
authors.initials: L
authors.lastname: Kochbati
authors.forename: N
authors.initials: N
authors.lastname: Chraïet
authors.forename: C
authors.initials: C
authors.lastname: Nasr
authors.forename: H
authors.initials: H
authors.lastname: Boussen
authors.forename: S
authors.initials: S
authors.lastname: Touati
authors.forename: K
authors.initials: K
authors.lastname: Ben Romdhane
authors.forename: M
authors.initials: M
authors.lastname: Maalej
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000532:radiotherapy