Serum S100beta protein in children with acute recurrent headache: a potentially useful marker for migraine.
OBJECTIVE
To examine the role of glia-derived S100beta protein and to evaluate its use as a biochemical marker in childhood acute recurrent headache.


METHODS
Twenty-five patients with acute recurrent headache (according to International Headache Society criteria) from our department's Headache Clinic were studied. Blood samples for measurement of serum S100beta were drawn: (1) < or = 3-hour post pain attack from our patients and (2) from 23 healthy controls.


RESULTS
Of the 25 patients evaluated, 15 suffered from migraine and 10 from tension-type headache (TTH). Statistical analysis of the mean values of S100beta levels demonstrated a significant elevation in children with migraine headache, with values higher than those of both children with TTH and controls (P = .001).


CONCLUSIONS
Our data suggest a direct relation between childhood migraine attacks and increased production of glial S100beta protein. Serum S100beta determination may be a useful biochemical marker for migraine in acute recurrent headache in childhood.
Papandreou
Ourania
O
First Department of Pediatrics, University of Athens, Goudi, Greece.
Soldatou
Alexandra
A
Tsitsika
Artemis
A
Kariyannis
Catherine
C
Papandreou
Thalia
T
Zachariadi
Asimina
A
Papassotiriou
Ioannis
I
Chrousos
George P
GP
D000208:Acute Disease; D000293:Adolescent; D015415:Biomarkers; D002648:Child; D005260:Female; D006261:Headache / Q000097:blood*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D011446:Prospective Studies; D012008:Recurrence; D009418:S100 Proteins / Q000097:blood*; D018781:Tension-Type Headache / Q000097:blood
D015415:Biomarkers; D009418:S100 Proteins