[The role of cytokines in ischemic stroke].
The subjects of the study were patients with acute ischemic stroke (IS), patients with residual effects of IS, their healthy relatives in families with IS background, and healthy controls; blood levels of cytokines in these groups were compared. This included measurement of levels of tumor necrosis factor a, interleukins (IL-beta, IL-6), and chemokins (monocyte chemotoxic factor-1 and cytokine-inducible neutrophile chemoattractant.) The study presents experimental evidence of involvement of cytokines in molecular pathological mechanisms of generation and development of inflammatory immune response in patients with IS. The results show that therapeutic correction directed towards modulation of inflammatory immune response at the level of cytokine expression, is a necessary part of prevention and treatment of stroke, as well as successful rehabilitation of stroke patients.
Arekelian
A A
AA
Boiadzhian
A S
AS
Petrek
M
M
Aĭvazian
V A
VA
Manucharian
G G
GG
Mkhoian
G G
GG
D000368:Aged; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000276:immunology / Q000628:therapy; D000071939:Stroke Rehabilitation; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D018925:Chemokines; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha