Prediction of the rodent carcinogenicity of 60 pesticides by the DEREKfW expert system.
The two-year rodent bioassay represents the golden standard for evaluating the carcinogenicity of chemicals. Because of practical and ethical reasons, alternative approaches have been investigated for many years. Among these approaches, the (quantitative) structure-activity relationships [(Q)SARs] offer promising perspectives for quickly screening a large number of chemicals. To increase the acceptance of (Q)SARs among the regulators, their predictive power needs to be scientifically validated. In this article, we tested the capacity of the DEREKfW expert system to qualitatively predict the rodent carcinogenicity and the genotoxic potential of 60 pesticides recently registered in Switzerland. The percentage of false negatives was found to be 31% for carcinogenicity. The associated sensitivity of 69% indicates that most of the pesticides with positive rodent bioassay results were detected by DEREKfW. On the other hand, the low specificity of 47% indicates that many pesticides may be flagged as carcinogenic while rodent bioassays would not confirm this potential. This may lead to unnecessary testing or the unnecessary restriction of a chemical.
Crettaz
Pierre
P
Swiss Federal Office of Public Health, 3003 Bern, Switzerland. Pierre.Crettaz@bag.admin.ch
Benigni
Romualdo
R
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005103:Expert Systems; D051379:Mice; D009153:Mutagens / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*; D011237:Predictive Value of Tests; D051381:Rats; D012984:Software; D013329:Structure-Activity Relationship; D013557:Switzerland
D002273:Carcinogens; D009153:Mutagens; D010575:Pesticides