title: Cofilin phosphatases and regulation of actin dynamics.
abstract: Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.
authors.affiliation: The Scripps Research Institute, Departments of Immunology and Cell Biology, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Timothy Y
authors.initials: TY
authors.lastname: Huang
authors.forename: Céline
authors.initials: C
authors.lastname: DerMardirossian
authors.forename: Gary M
authors.initials: GM
authors.lastname: Bokoch
mesh_terms: D051339:Actin Depolymerizing Factors / Q000502:physiology*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D014018:Tissue Distribution
chemical_list: D051339:Actin Depolymerizing Factors; D000199:Actins; D006867:Hydrolases; C496428:PDXP protein, human; D010749:Phosphoprotein Phosphatases; C484329:SSH1 protein, human; C034507:2-haloacid dehalogenase