title: Evaluating the effects of treatment for medical disorders: has the value of neuropsychological assessment been fully realized?
abstract: Cognitive functioning can be affected by medical disorders and by the regimens used to treat them. To evaluate the cognitive risks and benefits of specific medical treatments, an increasing number of medical clinical trials have included a formal neuropsychological evaluation. This selective review has three goals: (a) to survey the range of assessment techniques used with different patient populations (e.g., those with diabetes, chronic obstructive pulmonary disease [COPD], hypertension, HIV, or cardiac disease) and treatment regimens (e.g., medical management, pharmacotherapy, surgery), (b) to demonstrate how cognitive outcome measures can contribute to an understanding of the value of certain treatments, and (c) to identify critical conceptual and methodological problems. The utility of this approach is incontrovertible-most large-scale medical trials have found either no adverse cognitive side effects or improved cognitive functioning following treatment. Nevertheless, before cognitive measures are routinely included in medical clinical trials, investigators will have to resolve problems that include the measurement of behavior change over time and the identification of clinically significant impairment.
authors.affiliation: Western Psychiatrc Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Ryan
authors.forename: R
authors.initials: R
authors.lastname: Hendrickson