[Effect of extract of ginkgo bilboa leaf on early diabetic nephropathy].
OBJECTIVE
To study the effect of extract of Ginkgo bilboa leaf (EGB) on renal lesions of early diabetic nephropathy (DN).


METHODS
Sixty-eight patients with early DN were randomly divided into two groups, the control group (34 patients) and the treated group (34 patients). Patients in both groups received conventional therapy, while additional 9.6 mg EGB was orally taken by patients in the treated group, three times per day. The therapeutic course for both groups was three months. Indexes such as urinary microalbumin (mALB), alpha1-microglobulin (alpha1-MG), immunoglobulin (IgG), transferrin (TF), retinal binding protein (RBP) and N-acety-beta-D-glucosaminidase (NAG) before and after treatment between the two groups were compared respectively.


RESULTS
Compared with before treatment, mALB, alpha1-MG, IgG, TF, RBP and NAG obviously decreased with significant difference in the treated group after treatment (P < 0.05). However, no significant decrease in the above-mentioned indexes in the control group (P > 0.05).


CONCLUSIONS
EGB has the protective action on early DN.
Zhu
Hong-wen
HW
Department of Medicine, Anting Hospital, Jiading District, Shanghai. zhwen-426@163.com
Shi
Zheng-fang
ZF
Chen
Yun-yan
YY
D000328:Adult; D000368:Aged; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry
D004365:Drugs, Chinese Herbal