title: Five labdane diterpenoids from the seeds of Aframomum zambesiacum.
abstract: Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC(50) value of 4.97 microM.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Dschang, Box 67, Dschang, Cameroon.
authors.forename: Marguerite
authors.initials: M
authors.lastname: Kenmogne
authors.forename: Elise
authors.initials: E
authors.lastname: Prost
authors.forename: Dominique
authors.initials: D
authors.lastname: Harakat
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Jacquier
authors.forename: Michel
authors.initials: M
authors.lastname: Frédérich
authors.forename: Lucas B
authors.initials: LB
authors.lastname: Sondengam
authors.forename: Monique
authors.initials: M
authors.lastname: Zèches
authors.forename: Pierre
authors.initials: P
authors.lastname: Waffo-Téguo
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000145:classification / Q000627:therapeutic use; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D004224:Diterpenes; C433017:labdane