SUMO changes Sox for developmental diversity.
The finding that posttranslational modification of the SoxE transcription factors by SUMO regulates specific developmental programs (Taylor and LaBonne [2005], in the journal Developmental Cell) highlights the biological significance of SUMOylation in gene expression and underscores how much there is yet to learn about the function and regulation of this modification.
Gill
Grace
G
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006609:High Mobility Group Proteins / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D055758:SOX9 Transcription Factor; D055757:SOXE Transcription Factors; D025842:SUMO-1 Protein / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*; D014981:Xenopus / Q000196:embryology / Q000378:metabolism
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; C527923:SOX10 protein, human; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D055757:SOXE Transcription Factors; D025842:SUMO-1 Protein; D014157:Transcription Factors