[Progress of study on brain protective effect and mechanism of Polygonum multiflorum].
This paper reviews the brain protective effect and mechanism of Polygonum multiflorum (PM), its extracts and active component, tetrahydroxystilbene-glucoside (2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside) published in recent decade. They have major effects as calcium channel antagonists, antioxidant, cholinomimetic drugs and cholinesterase inhibitors, as well as actions in regulating cell apoptosis and prolonging the ageing. The brain protective mechanism of PM is multi-target, multi-link and multi-way. Therefore, PM has great applicative value in prevention and treatment of senile neuropathies, such as Alzheimer's disease, Parkinson's disease and vascular dementia, etc.
Wang
Wei
W
Institute of Geriatrics, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091. wjf43@yahoo.com.cn
Wang
Dan-qiao
DQ
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007859:Learning Disabilities / Q000188:drug therapy / Q000209:etiology; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D028502:Polygonum / Q000737:chemistry*; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*
D000975:Antioxidants; D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D018696:Neuroprotective Agents; D010936:Plant Extracts; D013267:Stilbenes; C093026:2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside