Leucovernine and acetylleucovernine, alkaloids from Leucojum vernum.
The fresh bulbs of Leucojum vernum provided seven tyrosine-derived alkaloids; two of them have not been reported before and are named leucovernine and acetylleucovernine. The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-hydroxyvittatine. These compounds have been isolated from this species for the first time. The structure determination was carried out by the combination of liquid-phase one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry.
Forgo
Peter
P
Department of Organic Chemistry, University of Szeged, H-6720 Szeged, Hungary. pforgo@chem.u-szeged.hu
Hohmann
Judit
J
D047151:Amaryllidaceae Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D006814:Hungary; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D047151:Amaryllidaceae Alkaloids; C506374:acetylleucovernine; C506373:leucovernine