[Changes of Th1, Th2 cells and correlative cytokines in allergic rhinitis].
OBJECTIVE
To evaluate the role of Th1, Th2 cells and correlative cytokines in the pathogenesis of allergic rhinitis.


METHODS
Albumin from chicken egg white was used to induce allergic rhinitis in SD rats. Flow cytometry was used to count the Th1 and Th2 cells in peripheral blood. And the content of INF-gamma and IL-4 in blood serum or mucosa homogenate was measured by enzyme-linked immunosorbent assay (ELISA) method.


RESULTS
Compared with healthy controls, Th1 was slightly lower and Th2 was significantly higher in the models (P < 0.05). Th1/Th2 ratio showed a clear deviation from normal balance (P < 0.01). INF-gamma decreased (but P > 0.05) and IL-4 clearly increased (P < 0.01) in blood serum or mucosa homogenate.


CONCLUSIONS
The changes of Th2 cells and correlative cytokines may play an important role in the pathogenesis of allergic rhinitis.
Zhao
Jiandong
J
Department of Otolaryngology, Second Hospital of Shandong University, Jinan 250012, China. jackzhao01@hotmail.com
Wang
Shizhen
S
Ma
Fengmei
F
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012220:Rhinitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines; D015847:Interleukin-4; D007371:Interferon-gamma