title: Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes.
abstract: The -112A>C polymorphism (rs10011540) of the gene for uncoupling protein 1 (UCP1) has been associated with type 2 diabetes mellitus in Japanese individuals. The aim of the present study was to investigate the effects of this polymorphism, as well as the well-known -3826A>G polymorphism (rs1800592), on clinical characteristics of type 2 diabetes. We determined the genotypes of the two polymorphisms in 93 Japanese patients with type 2 diabetes. Intramyocellular lipid content and hepatic lipid content (HLC) were measured by magnetic resonance spectroscopy. No significant differences in age, sex, BMI, or HbA1c level were detected between type 2 diabetic patients with the -112C allele and those without it. However, homeostasis model assessment for insulin resistance (p=0.0089) and HLC (p=0.012) was significantly greater in patients with the -112C allele. We did not detect an association of the -3826A>G polymorphism (rs1800592) of UCP1 gene with any measured parameters. These results suggest that insulin resistance caused by the -112C allele influences the susceptibility to type 2 diabetes.
authors.affiliation: Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Fukuyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohara
authors.forename: Yushi
authors.initials: Y
authors.lastname: Hirota
authors.forename: Kengo
authors.initials: K
authors.lastname: Maeda
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kuno
authors.forename: Masako
authors.initials: M
authors.lastname: Zenibayashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Teranishi
authors.forename: Kunichi
authors.initials: K
authors.lastname: Kouyama
authors.forename: Eiichi
authors.initials: E
authors.lastname: Maeda
authors.forename: Norihiro
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Masato
authors.initials: M
authors.lastname: Kasuga
mesh_terms: D017677:Age Distribution; D002352:Carrier Proteins / Q000235:genetics*; D015897:Comorbidity; D004252:DNA Mutational Analysis / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance / Q000235:genetics*; D007473:Ion Channels; D007564:Japan / Q000453:epidemiology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D024101:Mitochondrial Proteins; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution; D013223:Statistics as Topic; D000071256:Uncoupling Protein 1
chemical_list: D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1