Reliability of quantitative and qualitative tests to identify heterozygotes carrying severe or mild G6PD deficiency.
OBJECTIVE
To determine if the qualitative test (cytochemical) is more reliable than the quantitative test (differential pH-metry) in identifying heterozygous G6PD- subjects.


METHODS
Identification of heterozygous G6PD- subjects was done by the measurement of G6PD activity and by a cytochemical test.


RESULTS
A cytochemical test is more sensitive than differential pH-metry to identify heterozygous G6PD- subjects.


CONCLUSIONS
A cytochemical test is a reliable method for mass screening for G6PD deficiency to identify G6PD- heterozygotes.
Tagarelli
Antonio
A
Istituto di Scienze Neurologiche-CNR, Contrada Burga, 87050 Mangone, Cosenza, Italy. a.tagarelli@isn.cnr.it
Piro
Anna
A
Bastone
Loredana
L
Condino
Francesca
F
Tagarelli
Giuseppe
G
D000328:Adult; D004906:Erythrocyte Count; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007558:Italy; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012680:Sensitivity and Specificity; D044465:White People
D005954:Glucosephosphate Dehydrogenase