Yaequinolones J1 and J2, novel insecticidal antibiotics from Penicillium sp. FKI-2140.
[chemical reaction: see text]. Two novel insecticidal antibiotics with a p-methoxyphenylquinolinone skeleton fused with a pyran ring, yaequinolones J1 (1) and J2 (2), have been isolated from Penicillium sp. FKI-2140, and structures were elucidated by spectroscopic studies including various NMR experiments. The relative stereochemistries were assigned by NOE experiments. Yaequinolones J1 and J2 showed toxicity against Artemia salina (brine shrimp) with the MIC value of 6.25 microg/mL.
Uchida
Ryuji
R
The Kitasato Institute and Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Imasato
Rie
R
Shiomi
Kazuro
K
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007306:Insecticides; D011714:Pyrans; D015363:Quinolones; C512551:yaequinolone J1; C512552:yaequinolone J2