Epstein-Barr Virus DNA quantification: an adjunctive diagnostic marker for AIDS-associated lymphoma.
We report an HIV-positive patient who developed a unilateral retinitis and subsequent intracranial lesions. The finding of Epstein Barr virus (EBV) DNA at a > 1-log greater concentration in the vitreous compared to blood raised the possibility of a primary CNS non-Hodgkin's lymphoma, which was subsequently confirmed on brain biopsy. EBV DNA quantification acted as a diagnostic marker that led to a change in the management of our patient.
Ho
Shu Fen
SF
Birmingham and Midland Eye Centre, Birmingham, UK.
Fink
Colin
C
Murray
Philip I
PI
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis / Q000821:virology; D004279:DNA, Viral / Q000235:genetics*; D003937:Diagnosis, Differential; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications / Q000175:diagnosis* / Q000821:virology; D008297:Male; D016133:Polymerase Chain Reaction; D012173:Retinitis / Q000175:diagnosis / Q000209:etiology
D004279:DNA, Viral