Identification and preliminary SAR studies of (+)-Geodin as a glucose uptake stimulator for rat adipocytes.
(+)-Geodin (1) was isolated from Penicillium glabrum AJ117540 with activity that stimulates glucose uptake by rat adipocytes. Unlike insulin it is active in the presence of wortmannin. Dihydrogeodin (2) and sulochrin (3) which are the precursors of (+)-geodin biosynthesis were also isolated from the same fungus. Preliminary SAR studies of 1 showed some analogues had enhanced activity. Especially, the activities of racemic geodin and dibromo analogue (7a) were comparable to that of the natural product. Geodin (1), a known fungal metabolite, was isolated from Penicillium glabrum AJ117540 as an active substance (Fig. 1). Dihydrogeodin (2) and sulochrin (3), the precursors of 1, were also isolated from the same fungal extract. In this study, preliminary mechanistic insight and SAR are reported.
Sato
Seiichi
S
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki 210-8681, Japan. seiichi_sato@ajinomoto.com
Okusa
Noriyuki
N
Ogawa
Akiyo
A
Ikenoue
Takao
T
Seki
Tetsuya
T
Tsuji
Takashi
T
D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D001572:Benzofurans; D007328:Insulin; C052047:geodin; D005947:Glucose