title: Hepatic lipase gene polymorphism, pre-pregnancy overweight status and risk of preeclampsia among Peruvian women.
abstract: We examined the association between the hepatic lipase (LIPC) gene promoter polymorphism (-514C/T) and risk of preeclampsia among Peruvian women. We also evaluated whether this association is modified by maternal pre-pregnancy overweight status. Using a case control study design, 157 preeclampsia cases and 180 normotensive controls were enrolled in the study. Genotyping was conducted using PCR amplification, NlaIII enzyme digestion and gel electrophoresis. Logistic regression procedures were used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CI). After adjusting for confounding by maternal age, parity and pre-pregnancy body mass index (BMI), the relative risks of preeclampsia for women with LIPC -514CT and LIPC -514TT genotypes were 1.0 (95% CI 0.5-2.2) and 1.5 (95% CI 0.7-3.3) respectively, using women with LIPC -514CC genotype as a reference. Women who were both overweight and who had the LIPC -514TT genotype had a significant 3-fold increased risk of preeclampsia (Adj. OR:3.0 95% CI 1.3-6.8) as compared to those women who were not overweight and had the LIPC -514CC/CT genotype. In this study, we found that LIPC -514TT genotype and overweight status, when occurring together, were associated with a 3-fold increase in risk of preeclampsia among Peruvian women.
authors.affiliation: Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA. danenq@u.washington.edu
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Enquobahrie
authors.forename: Sixto E
authors.initials: SE
authors.lastname: Sanchez
authors.forename: Martin
authors.initials: M
authors.lastname: Muy-Rivera
authors.forename: Chunfang
authors.initials: C
authors.lastname: Qiu
authors.forename: Cuilin
authors.initials: C
authors.lastname: Zhang
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Austin
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams
mesh_terms: D015992:Body Mass Index; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005838:Genotype; D006801:Humans; D008049:Lipase / Q000235:genetics*; D016015:Logistic Models; D009765:Obesity / Q000150:complications*; D016017:Odds Ratio; D010568:Peru / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D016742:Preconception Care; D011247:Pregnancy; D012307:Risk Factors
chemical_list: C504173:LIPC protein, human; D008049:Lipase