Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma.
BACKGROUND
Breast cancer treatments are most effective when initiated early, with very poor efficacy against metastatic disease. In seeking a readily metastasizing mouse breast cancer model to facilitate the search for effective therapies, E0771 medullary adenocarcinomas implanted subcutaneously in syngeneic C57BL/6 mice were studied.


METHODS
Standard pathological, histological and immunological methodologies were used.


RESULTS
The aggressive estrogen receptor-positive tumor invaded locally into the peritoneal cavity in 56% of mice, as well as metastasizing to the lungs in 52% of mice. The metastasis was a spontaneous event and immunosuppression was seen (e.g. generation of lyphokine activated killer cells and allogeneic cytotoxic T lymphocytes cytolytic activities ex vivo were suppressed). Other pathological events noted as the tumor progressed were: bloody ascites (56%) and shock (72%), both attributed to local (peritoneal) tumor invasion.


CONCLUSIONS
The E0771 metastatic breast cancer model, which mimics the human disease, should be useful in testing new treatments against this disease and/or in examining the metastatic process.
Ewens
Andrew
A
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Mihich
Enrico
E
Ehrke
M Jane
MJ
D000818:Animals; D018276:Carcinoma, Medullary / Q000276:immunology / Q000473:pathology / Q000556:secondary*; D048708:Cell Growth Processes / Q000502:physiology; D005260:Female; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010534:Peritoneal Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary*