title: Knowledge-driven lead discovery.
abstract: Virtual screening encompasses several computational approaches which have proven valuable for identifying novel leads. These approaches rely on available information. Herein, we review recent successful applications of virtual screening. The extension of virtual screening methodologies to target families is also briefly discussed.
authors.affiliation: Aventis Pharma Deutschland GmbH, A Company of the Sanofi-Aventis Group, Chemical Sciences, Drug Design, Building G878, D-65926 Frankfurt am Main, Germany. bernard.pirard@sanofi-aventis.com
authors.forename: Bernard
authors.initials: B
authors.lastname: Pirard
mesh_terms: D001185:Artificial Intelligence; D019295:Computational Biology; D003198:Computer Simulation; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004364:Pharmaceutical Preparations / Q000145:classification; D021281:Quantitative Structure-Activity Relationship
chemical_list: D004364:Pharmaceutical Preparations