title: Total synthesis, NMR solution structure, and binding model of the potent histone deacetylase inhibitor FR235222.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università di Siena via A. Moro 2, 53100 Siena, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Rodriquez
authors.forename: Stefania
authors.initials: S
authors.lastname: Terracciano
authors.forename: Elena
authors.initials: E
authors.lastname: Cini
authors.forename: Giulia
authors.initials: G
authors.lastname: Settembrini
authors.forename: Ines
authors.initials: I
authors.lastname: Bruno
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bifulco
authors.forename: Maurizio
authors.initials: M
authors.lastname: Taddei
authors.forename: Luigi
authors.initials: L
authors.lastname: Gomez-Paloma
mesh_terms: D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; C474179:FR 235222; D056572:Histone Deacetylase Inhibitors; D010456:Peptides, Cyclic; D012996:Solutions; D006655:Histone Deacetylases