Rescue therapy with terlipressin by continuous infusion in a child with catecholamine-resistant septic shock.
A 2-month-old female infant presented with septic shock, refractory to high doses of catecholamines. Continuous infusion of terlipressin at a rate of 10 mcg/kgh produced a significant increase in the mean arterial pressure that was evident within half and hour, so allowing a reduction in the rate of catecholamine infusion. However, 18 h later, the blood pressure fell again and finally the patient died. This case shows the potential value of terlipressin infusion to restore normal mean arterial pressure in children with vasodilatory shock and hypotension refractory to catecholamines.
Zeballos
Gonzalo
G
Pediatric Critical Care Unit, Gregorio Marañón University Hospital, Dr. Castelo, 49, 28007 Madrid, Spain.
López-Herce
Jesús
J
Fernández
Carmen
C
Brandstrup
Kay B
KB
Rodríguez-Núñez
Antonio
A
D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D007223:Infant; D007262:Infusions, Intravenous; D008236:Lypressin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012772:Shock, Septic / Q000150:complications / Q000503:physiopathology*; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
D002395:Catecholamines; D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin