title: Evaluation of two types of leukocyte removal filters on transfusion dependent thalassaemics.
abstract: The advent of leukocyte filters has enabled effective removal of leukocytes from certain blood products thus avoiding many adverse effects of blood transfusion. Many different materials have been incorporated into these filters to achieve >95% leukocyte removal. In this study we evaluated the efficacy of leukocyte removal of two different filters, using actual bedside transfusion settings involving patients with transfusion dependent thalassaemia. Fifty-one transfusion events were randomised to use either a polyurethane filter or a non-woven polyester filter. We found that the two filters achieved 98.4% and 96.2% leukocyte removal respectively (p = 0.022). We also found no significant correlation between pre-filtration white blood cell count and the volume transfused with the efficacy of leukodepletion. No untoward events or transfusion reactions were observed during the study.
authors.affiliation: Department of Paediatrics, Faculty of Medicine UKM, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia. rahmanj@hukm.ukm.my
authors.forename: R
authors.initials: R
authors.lastname: Jamal
authors.forename: N R
authors.initials: NR
authors.lastname: Mazeni
authors.forename: H
authors.initials: H
authors.lastname: Hussin
mesh_terms: D005374:Filtration / Q000295:instrumentation*; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation* / Q000379:methods; D007962:Leukocytes; D013789:Thalassemia / Q000150:complications / Q000628:therapy*; D065227:Transfusion Reaction