Absence of Epstein-Barr virus in esophageal squamous cell carcinoma.
It is strongly suspected that the Epstein-Barr virus (EBV) plays a role in the genesis of nasopharyngeal and gastric carcinoma. The aim of this study was to search for such a connection between esophageal squamous cell carcinoma (ESCC) and EBV. We investigated 104 surgically resected esophageal cancers using in situ hybridization (ISH) for EBV-encoded RNA (EBER). We found no EBER-positive cancer cells in any tests, although there were five samples in which EBER-positive tumor-infiltrating lymphocytes (TILs) were found. We conclude from this study that EBV is not associated with ESCC.
Sunpaweravong
S
S
Department of Surgery, Songklanagarind Hospital, Prince of Songkla University, Songkla, Thailand. susomkia@medicine.psu.ac.th
Mitarnun
W
W
Puttawibul
P
P
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D004938:Esophageal Neoplasms / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D016246:Lymphocytes, Tumor-Infiltrating / Q000821:virology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis
D012367:RNA, Viral