Computer simulation of the influence of cellular adhesion on the morphology of the interface between tissues of proliferating and quiescent cells.
We investigate the influence of cellular adhesion on the morphology of the interface between a tissue of proliferating and quiescent cells using the cellular Potts model. We show that a decrease in surface tension changes the morphology of the interface and that only for negative surface tensions cell detachment from the proliferative tissue occurs suggesting that this might be a necessary condition for metastatization in malignant neoplasies.
Knewitz
Marcos A
MA
Laboratório de Bioinformática e Biologia Computacional, Centro de Ciências Exatas e Tecnológicas, Universidade doVale do Rio dos Sinos, 93022-000 São Leopoldo, RS, Brazil.
Mombach
José C M
JC
D000465:Algorithms; D002448:Cell Adhesion; D049109:Cell Proliferation; D003198:Computer Simulation; D017709:Fractals; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D009361:Neoplasm Invasiveness