Carcinoma of the jejunum with multideposit peritoneal seeding, resection and intraperitoneal chemotherapy.
Jejunal adenocarcinoma is rare, often presenting late with widespread intraperitoneal disease. Intraperitoneal chemotherapy (IPC) has been shown in non-randomized studies to improve the survival of patients presenting with intraperitoneal metastases from carcinoma of the colon, appendix and stomach and in primary peritoneal malignancies including mesothelioma and pseudomyxoma peritonei, providing that adequate operative cytoreduction can be performed. A case is presented of obstructive jejunal adenocarcinoma in which 19 intraperitoneal deposits were excised. The patient was treated successfully with immediate postoperative IPC followed by systemic chemotherapy. This condition is reviewed along with the rationale for IPC.
Innis
M
M
Department of Oncology, Queen Elizabeth Hospital, The University of the West Indies, Cave Hill, Barbados.
Sandiford
N
N
Shenoy
R K
RK
Prussia
P R
PR
Zbar
A
A
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000971:Antineoplastic Combined Chemotherapy Protocols; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D007415:Intestinal Obstruction / Q000209:etiology / Q000601:surgery; D007580:Jejunal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery*
D002955:Leucovorin; D005472:Fluorouracil