Anti-inflammatory activity of Croton cuneatus aqueous extract.
The aqueous extract of Croton cuneatus Klotz. (Euphorbiaceae), was tested for its antinociceptive effects using chemical and thermal test models in mice. Anti-inflammatory activity was determined in Sprague-Dawley rats in a model of acute plantar inflammation induced by bovine serum albumin. Croton cuneatus aqueous extract at doses of 7 mg/kg showed a significant anti-inflammatory effect compared with commonly used non-stereoidal drugs as ketoprofen, sodium diclofenac and ASA (acetylsalicylic acid).
Suárez
Alírica I
AI
Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40109, Caracas, Venezuela. asuarez@strix.ciens.ucv.ve
Blanco
Zuleyma
Z
Compagnone
Reinaldo S
RS
Salazar-Bookaman
María M
MM
Zapata
Varlin
V
Alvarado
Claudia
C
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D029802:Croton / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts