[Two case reports on intra-tumor injection therapy of dendritic cells].
DC (dendritic cells) vaccine therapy against cancer has attracted attention in recent years. However, the existence of the immunosuppressive state in cancer individuals leads to anergy and failure in cytotoxic T cell (CTL) induction and DC migration to the target organ. It has been reported that injected intra-tumor DC is expected to work phagocytosis of the tumor as a localized effect, the consequent CTL induction in the tumor and the regional lymphnodes, resulting in a systemic effect. Two cases reported in this article were performed with intra-tumor DC injection therapy by means of EUS (endoscopic ultrasonography) which indicated interesting immunoreaction.
Kanazawa
Masashi
M
Dept. of Surgery II, Fukushima Medical University.
Yoshihara
Kazue
K
Abel
Hiroyuki
H
Suzuki
Satoshi
S
Endoh
Yoshiyuki
Y
Onogi
Hitoshi
H
Ohki
Shinji
S
Takita
Ken-ichi
K
Sekikawa
Kouji
K
Takenoshita
Seiichi
S
Takagi
Tadayuki
T
Irisawa
Atsushi
A
Satoh
Yukio
Y
Ogata
Takashi
T
Ohto
Hitoshi
H
D000368:Aged; D002465:Cell Movement / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology*; D004938:Esophageal Neoplasms / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D015552:Injections, Intralesional; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D018227:Sarcoma, Clear Cell / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology