Applications of microwave-assisted organic synthesis on the multigram scale.
This review presents a summary of reactions performed using microwave irradiation on a multigram scale. Results are described in the context of existing equipment, and equipment currently in development, for the processing of multigram to kilogram quantities of materials including single- and multimode microwave reactors and batch, batch-flow and continuous-flow systems. Although limited in number, reports found in the literature to date suggest that with appropriate controls, reproducible scale-up of microwave reactions is feasible and requires minimal re-optimization of laboratory-scale reaction conditions. This feature, along with the dramatic reductions in reaction time generally observed for microwave reactions suggests that application of this technology in process research could be beneficial.
Wolkenberg
Scott E
SE
Merck & Co Inc, Technology Enabled Synthesis Group, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA. scott_wolkenberg@merck.com
Shipe
William D
WD
Lindsley
Craig W
CW
Guare
James P
JP
Pawluczyk
Joseph M
JM
D001578:Benzopyrans / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques; D004148:Dioxolanes / Q000138:chemical synthesis; D008872:Microwaves; D009930:Organic Chemicals / Q000138:chemical synthesis*; D011799:Quinazolines / Q000138:chemical synthesis; D013696:Temperature; D013859:Thiocarbamates / Q000138:chemical synthesis; D013997:Time Factors
D001578:Benzopyrans; D004148:Dioxolanes; D009930:Organic Chemicals; D011799:Quinazolines; D013859:Thiocarbamates