Cooperative type of platelet hypersensitivity to ADP.
We found that gestosis is associated with platelet hypersensitivity to ADP. Cell P2X1 receptors exhibited a positive cooperative response to ADP (EC(50)=10.88+/-3.70 nM, Hill constant n=2.59+/-0.50 rel. units). Cooperative binding of ADP to platelet P2X1 receptors was also observed during incubation of cells from pregnant women with isosorbide dinitrate.
Shabanova
E Yu
EY
Laboratory for Physiology of Respiration, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg. helen_shabanova@mail.ru
Mindukshev
I V
IV
Malakhovskaya
E A
EA
Vivulanets
E V
EV
Petrishchev
N N
NN
Krivchenko
A I
AI
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D018048:Receptors, Purinergic P2 / Q000502:physiology; D058469:Receptors, Purinergic P2X
D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D000244:Adenosine Diphosphate