Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power.
The antioxidant properties of substituted diarylamines in the benzo[b]thiophene series were evaluated by their reducing power and free radical scavenging activity. The results were compared with those of standards: acid ascorbic for the first method and BHA and BHT for the second. For both methods it was possible to establish some structure-activity relationships (SARs) based on the position of the arylamination on the benzo[b]thiophene moiety, the presence of different substituents on the phenyl ring (F, 1 or 2 OMe) and on the thiophene ring (H, CO(2)Et, CO(2)H).
Ferreira
Isabel C F R
IC
Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Sta. Apolónia, Apartado 1172, 5301-855 Bragança, Portugal. iferreira@ipb.pt
Queiroz
Maria-João R P
MJ
Vilas-Boas
Miguel
M
Estevinho
Letícia M
LM
Begouin
Agathe
A
Kirsch
Gilbert
G
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001205:Ascorbic Acid; D002384:Catalysis; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010165:Palladium / Q000737:chemistry; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry*
D000588:Amines; D000975:Antioxidants; D016166:Free Radical Scavengers; D013876:Thiophenes; C088015:benzothiophene; D010165:Palladium; D001205:Ascorbic Acid