A variant chronic B-cell lymphoma characterized by villous cells with novel immunophenotypic and cytogenetic profiles.
The less common chronic B-cell lymphomas include hairy cell leukemia, hairy cell leukemia variant and splenic lymphoma with villous lymphocytes. These disease entities can sometimes cause a diagnostic dilemma; however, immunophenotypic markers have been identified as disease specific and scoring systems have been proposed to assist the process. This study reports a case of a chronic B-cell lymphoma with long cytoplasmic projections which does not fit into any of the published disease categories based upon a combination of clinical and morphological features and immunophenotyping. Furthermore, this case featured a combination of cytogenetic abnormalities not previously described in the published literature in association with a B-cell lymphoproliferative disorder.
Coupland
L A
LA
Haematology Department, The Canberra Hospital, Garran, ACT, Australia. lucy.coupland@act.gov.au
Brun
M
M
Jammu
V
V
D'Rozario
J M
JM
D022081:Cell Surface Extensions / Q000473:pathology*; D002908:Chronic Disease; D020732:Cytogenetic Analysis / Q000379:methods*; D020869:Gene Expression Profiling; D014644:Genetic Variation; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity