title: Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapy.
abstract: Zidovudine (ZDV) has been associated with 'ragged-red' fibre myopathy, due to its effects on myocyte mitochondria. Usually this is reversible with cessation of ZDV. We report a 52-year-old man, who in 1985 developed ragged-red fibre myopathy 14 years after diagnosis of HIV infection while on effective ZDV-based combination antiretroviral therapy (ART). He was treated with the mitochondrial anti-oxidant coenzyme Q10 and made an excellent recovery, without change of ARTs. This suggests a novel therapy for further investigation targeted at ZDV induced myopathy, potentially allowing continuation of antiviral treatments including ZDV.
authors.affiliation: Cardiac Surgical Research Unit, Alfred Hospital & Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia. f.rosenfeldt@alfred.org.au
authors.forename: Franklin L
authors.initials: FL
authors.lastname: Rosenfeldt
authors.forename: Anne
authors.initials: A
authors.lastname: Mijch
authors.forename: Graham
authors.initials: G
authors.lastname: McCrystal
authors.forename: Clare
authors.initials: C
authors.lastname: Sweeney
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pepe
authors.forename: Melissa
authors.initials: M
authors.lastname: Nicholls
authors.forename: Xenia
authors.initials: X
authors.lastname: Dennett
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D003067:Coenzymes; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D015215:Zidovudine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D003067:Coenzymes; D018894:Reverse Transcriptase Inhibitors; D014451:Ubiquinone; D015215:Zidovudine; C024989:coenzyme Q10