title: The control of dyslipidemia in outpatient clinics in Greece (OLYMPIC) Study.
abstract: The objective of this study was to determine the proportion of Greek patients referred to outpatient clinics for dyslipidemia who achieved the low-density lipoprotein cholesterol (LDL-C) goal defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) guidelines, using lifestyle changes, lipid-lowering drug treatment (LLDT), or both. Adult patients with dyslipidemia, who had been receiving a hypolipidemic diet and/or LLDT for at least 3 months were assessed in a multicenter study performed at 66 sites across Greece. Patients were followed up for an additional 3-month treatment period. Lipid levels were recorded at baseline and at the end of the study. The primary endpoint was the proportion of patients achieving their individual LDL-C target at the end of the study, according to their coronary heart disease (CHD) risk status or its equivalents, as defined by the NCEP-ATP III guidelines. Multivariate logistic models were used to identify determinants of undertreatment. The study included 2,660 adults (20-75 years) from 7 regions of Greece. Of the evaluable sample (n = 2,211; men 51%; mean age 62 +/-9 years) 81% were receiving LLDT (96% with statins and 3% with fibrates), 44% had a history of CHD, 61% arterial hypertension, 36% diabetes, and 26% a family history of premature CHD. Overall, 6% were at low CHD risk, 30% at medium CHD risk, and 63% at high CHD risk. At the end of the study, 26% of all patients and 30% of those receiving LLDT achieved the NCEP-specified LDL-C target levels. The percentage of patients at LDL-C goal according to CHD risk status was: low risk 67% (95% CI = 59-75), medium risk 29% (95% CI = 26-33), and high risk 20% (95% CI = 18-22). Statins proved to be more effective than fibrates (p <0.0001). Atorvastatin-treated subjects (n = 1,222, mean dose 19 mg/day) attained the LDL-C target (31% of the cases) at a higher rate than those receiving other LLDT (n = 574, 26% at target, p <0.01) or not receiving drug treatment (n = 415, 8%, p <0.001). This outcome was more evident in the high-CHD risk group (n = 1,402, 26% with atorvastatin vs 16% with other LLDT and 3% not receiving LLDT attained the LDL-C goal, ANOVA, p <0.001). The majority of dyslipidemic patients receiving LLDT, mainly those with high-CHD risk, are not achieving the NCEP LDL-C target. This is mainly explained by inadequate dose titration to ensure target goals are met. Promoting healthy lifestyle and appropriate LLDT (potent statins with sufficient dose titration) must be implemented to ensure that patients attain LDL-C treatment goals and thus benefit from the reduction in individual CHD risk.
authors.affiliation: Dpathologiki@evaggelismos-hosp.gr
authors.forename: E J
authors.initials: EJ
authors.lastname: Diamantopoulos
authors.forename: V G
authors.initials: VG
authors.lastname: Athyros
authors.forename: G K
authors.initials: GK
authors.lastname: Yfanti
authors.forename: E N
authors.initials: EN
authors.lastname: Migdalis
authors.forename: M
authors.initials: M
authors.lastname: Elisaf
authors.forename: P E
authors.initials: PE
authors.lastname: Vardas
authors.forename: A S
authors.initials: AS
authors.lastname: Manolis
authors.forename: D T
authors.initials: DT
authors.lastname: Karamitsos
authors.forename: E S
authors.initials: ES
authors.lastname: Ganotakis
authors.forename: D
authors.initials: D
authors.lastname: Hatseras
mesh_terms: D000328:Adult; D000368:Aged; D000554:Ambulatory Care Facilities; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000209:etiology / Q000517:prevention & control; D018752:Diet, Fat-Restricted; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000628:therapy*; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006115:Greece; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D018570:Risk Assessment; D040242:Risk Reduction Behavior; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents