Beta-arrestin goes nuclear.
Arrestins have important roles in the cytoplasm and at the plasma membrane, including the desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of Cell, Kang et al. (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters.
Beaulieu
Jean-Martin
JM
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Caron
Marc G
MG
D000107:Acetylation; D000818:Animals; D019390:Arrestins / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D000071557:beta-Arrestins
D019390:Arrestins; D006657:Histones; D043562:Receptors, G-Protein-Coupled; D000071557:beta-Arrestins