title: Familial mediterranean fever-related nephrotic syndrome and successful full-term pregnancy.
abstract: Familial Mediterranean fever (FMF) is a systemic disease with an autosomal recessive inheritance. The most serious complication of FMF is renal amyloidosis. Pregnancy may adversely affect renal function in FMF patients with amyloidosis and nephrotic syndrome. A 20-year-old woman with FMF related nephrotic syndrome became pregnant while receiving colchicine therapy. Colchicine treatment was continued during pregnancy with close observation. She gave birth to a 2400 g healthy female newborn at the 38th week of gestation. Pregnancy and neonatal outcome were uneventful. It is advisable to continue colchicine treatment during conception and pregnancy in FMF patients with amyloid related nephrotic syndrome. Colchicine treatment with bed rest, protein reinforcement, acetylsalicylic acid administration and close follow-up may improve the outcome of pregnancy in FMF patients.
authors.affiliation: Department of Obstetrics and Gynecology, Haydarpasa Training Hospital, Istanbul, Turkey. ltutuncu@yahoo.com
authors.forename: Levent
authors.initials: L
authors.lastname: Tutuncu
authors.forename: Enes Murat
authors.initials: EM
authors.lastname: Atasoyu
authors.forename: Rifki
authors.initials: R
authors.lastname: Evrenkaya
authors.forename: Ercument
authors.initials: E
authors.lastname: Mungen
mesh_terms: D003078:Colchicine / Q000008:administration & dosage*; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006074:Gout Suppressants / Q000008:administration & dosage*; D006801:Humans; D050498:Live Birth; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy
chemical_list: D006074:Gout Suppressants; D003078:Colchicine