title: A 15-year-old girl with a spindle cell carcinoma of the parotid gland. A diagnostic challenge solved by immunohistochemistry and cytogenetic analysis.
abstract: Spindle cell carcinoma is a rare neoplasm of the upper respiratory tract which occurs in adults, most commonly in the larynx. In the literature only one case of spindle cell carcinoma, located in the maxilla, has been reported in a child. We report the first presentation of a spindle cell carcinoma in a child, which was located in the parotid gland, together with the clinical course. The diagnostic challenge associated with this unusual disorder is elucidated, as well as the role of immunohistochemical and cytogenetic examination to define the nature of these lesions.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Maastricht, Maastricht, The Netherlands. jbru@skno.azm.nl
authors.forename: Jan W
authors.initials: JW
authors.lastname: Brunings
authors.forename: Ann
authors.initials: A
authors.lastname: Driessen
authors.forename: Jos M A
authors.initials: JM
authors.lastname: De Jong
authors.forename: Johannes J
authors.initials: JJ
authors.lastname: Manni
mesh_terms: D000293:Adolescent; D002277:Carcinoma / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D020732:Cytogenetic Analysis / Q000379:methods*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008175:Lung Neoplasms / Q000556:secondary; D037981:Neck Dissection; D010306:Parotid Gland / Q000473:pathology* / Q000601:surgery; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery