Effect of gender on antinociceptive effect of paroxetine in hot plate test in mice.
OBJECTIVE
Many studies have reported both a gender difference in the rates of depression and its treatment by using any of the widely used antidepressant drug groups. Some studies suggest that females respond more poorly to tricyclic antidepressants than males and appear to respond better to selective serotonin reuptake inhibitors (SSRI). There is no study investigating the analgesic/antinociceptive effects of antidepressant drugs on the basis of gender difference. In this study, we aimed to investigate the antinociceptive effect of paroxetine on the basis of gender difference.


METHODS
The antinociceptive effect of paroxetine was tested using hot plate test in Balb/c mice (30-40 g). The animals were divided into eight groups on the basis of gender.


RESULTS
While paroxetine did not induce an antinociceptive effect in both sex at a dose of 1 mg kg(-1), it showed significant antinociceptive effects in both sex at a dose of 5 or 10 mg kg(-1). None of the doses of paroxetine revealed a gender difference in its antinociceptive action.


CONCLUSIONS
There are several studies showing positive or negative evidence on the gender difference of paroxetine's antidepressant effect, but in the literature there is no study about the gender difference of paroxetine's or any other SSRI drug's antinociceptive effect. In conclusion, our results do not show any gender difference in antinociceptive effect of paroxetine that may be important especially when it would be used as an adjuvant agent in some painful conditions.
Duman
Erdem N
EN
Karadeniz Technical University, School of Medicine, Department of Anesthesiology, TR-61187 Trabzon, Turkey.
Kesim
Murat
M
Kadioglu
Mine
M
Ulku
Cunay
C
Kalyoncu
Nuri I
NI
Yaris
Ersin
E
D000700:Analgesics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D017374:Paroxetine / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012727:Sex Characteristics; D013997:Time Factors
D000700:Analgesics; D017374:Paroxetine