title: Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression.
abstract: The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
authors.affiliation: Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543.
authors.forename: Siew Hong
authors.initials: SH
authors.lastname: Lam
authors.forename: Yi Lian
authors.initials: YL
authors.lastname: Wu
authors.forename: Vinsensius B
authors.initials: VB
authors.lastname: Vega
authors.forename: Lance D
authors.initials: LD
authors.lastname: Miller
authors.forename: Jan
authors.initials: J
authors.lastname: Spitsbergen
authors.forename: Yan
authors.initials: Y
authors.lastname: Tong
authors.forename: Huiqing
authors.initials: H
authors.lastname: Zhan
authors.forename: Kunde R
authors.initials: KR
authors.lastname: Govindarajan
authors.forename: Serene
authors.initials: S
authors.lastname: Lee
authors.forename: Sinnakarupan
authors.initials: S
authors.lastname: Mathavan
authors.forename: Karuturi R Krishna
authors.initials: KR
authors.lastname: Murthy
authors.forename: Donald R
authors.initials: DR
authors.lastname: Buhler
authors.forename: Edison T
authors.initials: ET
authors.lastname: Liu
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Gong
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002273:Carcinogens; D017124:Conserved Sequence; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D015027:Zebrafish / Q000235:genetics* / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D009363:Neoplasm Proteins