Polymer-assisted solution-phase chemical library synthesis.
Polymer-assisted solution-phase (PASP) synthesis has become a prevalent method for the parallel synthesis of chemical libraries. PASP methodology enables the chemist to prepare libraries of compounds more quickly and efficiently than previously. PASP technology encompasses a number of purification techniques for intermediate and final product purification. This methodology continues to progress, providing the practitioner with a broad range of ingenious purification methods, enabling multi-step syntheses of complex compounds. This review covers significant new advances in the use of tagged-reagents/substrates, resin capture-release techniques and PASP multi-step synthesis, some of which incorporate microwave heating and automation.
Parlow
John J
JJ
Pfizer Inc, Department of Medicinal & Parallel Chemistry, 700 Chesterfield Parkway West AA2E, Chesterfield, MO 63017, USA. john.j.parlow@pfizer.com
D000873:Anthracenes / Q000737:chemistry; D001331:Automation; D002614:Chelating Agents / Q000737:chemistry; D011232:Chemical Precipitation; D020650:Combinatorial Chemistry Techniques; D003497:Cyclic N-Oxides / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D007475:Ion Exchange Resins / Q000737:chemistry; D008872:Microwaves; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000302:isolation & purification; D010720:Phosphines; D011108:Polymers / Q000737:chemistry*; D012996:Solutions
D000873:Anthracenes; D002614:Chelating Agents; D003497:Cyclic N-Oxides; D007202:Indicators and Reagents; D007475:Ion Exchange Resins; D009930:Organic Chemicals; D010720:Phosphines; D011108:Polymers; D012996:Solutions; C003959:TEMPO