title: Impact of pathogen burden on in-stent restenosis in patients after coronary stent implantation.
abstract: BACKGROUND
  Although some certain infectious pathogens could be detected in the patients with coronary artery disease, the roles of these infectious factors in the development of coronary artery diseases remain largely unknown. Since the number of infectious pathogens has been argued to be relative to the coronary artery diseases, we therefore examined whether there is a link between the number of infections and the incidence of in-stent restenosis after stent implantation.
  
  
  METHODS
  One hundred and eighty-one patients were enrolled in this study. Infectious pathogens including serum anti-Chlymydia pneumoniae, cytomegalovirus, Helico pylori, human herpes simplex virus-1, human herpes simplex virus-2 antibodies and hepatitis B virus antigen were measured in all patients before coronary stent implantation. Coronary angiography was performed before, immediately after and 6 months after stent implantation.
  
  
  RESULTS
  Restenosis rate 6 months post stent implantation was similar in patients with low pathogen burden (< 3 pathogens, 33.3%) to those with high pathogen burden (> or = 3 pathogens, 29.1%).
  
  
  CONCLUSIONS
  Previous infections with Chlymydia pneumoniae, cytomegalovirus, Helico pylori, human herpes simplex virus-1, human herpes simplex virus-2 and hepatitis B virus do not contribute to the incidence of restenosis after stent implantation.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: Niu
authors.forename: Jun-bo
authors.initials: JB
authors.lastname: Ge
authors.forename: Cong-feng
authors.initials: CF
authors.lastname: Xu
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Shi
authors.forename: Xue-juan
authors.initials: XJ
authors.lastname: Jin
authors.forename: Ju-ying
authors.initials: JY
authors.lastname: Qian
authors.forename: Yun-zeng
authors.initials: YZ
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015607:Stents / Q000009:adverse effects*