title: Asymmetric synthesis of chiral 4-substituted 5,5-diethyl oxazolidin-2-ones as potential effective chiral auxiliaries.
abstract: Four new chiral 4-substituted 5,5-diethyl oxazolidin-2-ones (5a-5d) as potential effective chiral auxiliaries were synthesized from readily available amino acids via asymmetric etherification, Boc protection, Grignard reaction and cyclization reactions in four steps with overall yields of 50-60%.
authors.affiliation: Department of Applied Chemistry, Center for Advanced Studies of Medicinal and Organic Chemistry, Yunnan University, Kunming 650091, China.
authors.forename: J-F
authors.initials: JF
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Nie
authors.forename: L-J
authors.initials: LJ
authors.lastname: Yang
authors.forename: R
authors.initials: R
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Lin
mesh_terms: D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D023303:Oxazolidinones