Exploring soft matter: liposomal vesicles and their tethers.
The malleability of soft matter such as vesicular systems, allows their mechanical manipulation into various interesting structures. Their inherent elastic membrane properties can be utilized in fabricating micro-scaled transport machineries. In this paper, we have described several features of research carried out in our laboratory. This includes the self-healing ability of multilamellar liposome on removal of their inner core. The formation of tethers from their outer bilayers into complex networks has been demonstrated. Photo enhancement of images has revealed the apparent existence of narrow channels inside such tethers. The tethers channels were subsequently used as transport conduits to carry solid polystyrene microspheres as well as large liposomes larger than the tether diameter under controllable speeds of up to 2 microm s(- 1). The possibility of producing multi-compartment liposomal systems connected to each other directly by fusion or indirectly via tether networks has provided us with a system capable of transporting components from one vesicle entity to another.
Nasseri
Behrooz
B
Centre for Drug Delivery Research, School of Pharmacy, University of London, UK. behrooz.nasseri@ulsop.ac.uk
Fasciolo
Alessandro
A
D001692:Biological Transport; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008566:Membranes / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry
D008051:Lipid Bilayers; D008081:Liposomes; D011137:Polystyrenes