Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons.
Sequencing studies of the glycoprotein G gene were performed in human respiratory syncytial virus (hRSV) strains detected by reverse-transcription polymerase chain reaction directly from nasopharyngeal aspirates of hospitalized children < or =3 years old over 2 winters. Clinical data were compared between 106 children infected with group A hRSV (96 GA2 genotypes) and 94 children infected with hRSV group B (62 GB3 genotypes). A severity index was defined by assigning 1 point each for the use of >30% supplemental oxygen, admission to an intensive-care unit, and duration of hospital stay of >5 days. Group A and genotype GA2 strains were associated with greater severity of hRSV disease than were group B strains.
Gilca
Rodica
R
Laval University, Quebec, Canada. rodica.gilca@ssss.gouv.qc.ca
De Serres
Gaston
G
Tremblay
Mireille
M
Vachon
Marie-Louise
ML
Leblanc
Eric
E
Bergeron
Michel G
MG
Dery
Pierre
P
Boivin
Guy
G
D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D008297:Male; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D012621:Seasons; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D014760:Viral Fusion Proteins / Q000235:genetics
C502275:G glycoprotein, Respiratory syncytial virus; D014760:Viral Fusion Proteins