title: Expression of CD1d in human scalp skin and hair follicles: hair cycle related alterations.
abstract: BACKGROUND
  CD1d belongs to a family of antigen presenting molecules that are structurally and distantly related to the classic major histocompatibility complex class I (MHC I) proteins. However, unlike MHC I molecules, which bind protein antigens, CD1d binds to lipid and glycolipid antigens. CD1d is expressed by cells of lymphoid and myeloid origin, and by cells outside of the lymphoid and myeloid lineages, such as human keratinocytes of psoriatic skin.
  
  
  OBJECTIVE
  To investigate whether CD1d is also expressed in sun exposed skin and in the immuno-privileged anagen hair follicle.
  
  
  METHODS
  CD1d immunoreactivity was studied in human scalp skin and hair follicles of healthy women in situ by immunofluorescent and light microscopic immunohistology. Skin biopsies were obtained from normal human scalp containing mainly anagen VI hair follicles from women (age, 53-57 years) undergoing elective plastic surgery.
  
  
  RESULTS
  CD1d showed strong immunostaining in human scalp skin epidermis, pilosebaceous units, and eccrine glands. In the epidermis, CD1d was strongly expressed by basal and granular keratinocytes. In hair follicles, CD1d was expressed in the epithelial compartment and showed hair cycle related alterations, with an increase in the anagen and a reduction in the catagen and telogen phases.
  
  
  CONCLUSIONS
  These results suggest that CD1d plays a role in human scalp skin immunology and protection against lipid antigen rich infectious microbes. They also raise the question of whether keratinocytes of the immuno-privileged anagen hair follicle can present lipid antigens to natural killer T cells. These data could help provide new strategies for the manipulation of hair related disorders.
authors.affiliation: Department of Zoology, Sohag Faculty of Science, South Valley University, Sohage, 44106 Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Adly
authors.forename: M A
authors.initials: MA
authors.lastname: Adley
authors.forename: H A
authors.initials: HA
authors.lastname: Assaf
authors.forename: M
authors.initials: M
authors.lastname: Hussein
mesh_terms: D018949:Antigens, CD1 / Q000378:metabolism*; D055610:Antigens, CD1d; D004439:Eccrine Glands / Q000276:immunology; D004817:Epidermis / Q000276:immunology; D005260:Female; D018859:Hair Follicle / Q000254:growth & development / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D015603:Keratinocytes / Q000276:immunology; D008875:Middle Aged; D012535:Scalp / Q000276:immunology*; D012627:Sebaceous Glands / Q000276:immunology; D012867:Skin / Q000276:immunology*
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human