[The role of CD25 antibody in unrelated hematopoietic stem cell transplantation].
OBJECTIVE
To explore the role of CD(25) antibody on engraftment and graft-versus-host disease (GVHD) prophylaxis in unrelated hematopoietic stem cell transplantation (UHSCT).


METHODS
CD(25) 1 mg/kg was given on day 1, day 4 post-transplantation in 27 patients of UHSCT.


RESULTS
Hematopoietic recovery was obtained in 26 patients. One patient died before hematopoietic recovery. Acute GVHD occurred in 17 patients and 6 patients with II or more than degree acute GVHD (23%). Three patients experienced relapse and other 3 patients with serious infection. In these 26 eligible patients, 19 patients got disease free survival.


CONCLUSIONS
CD(25) antibody plays an important role on engraftment and GVHD prophylaxis in the treatment of UHSCT and does not increase rate of leukemia relapse. It provides a way of GVHD prophylaxis in unrelated and HLA mismatched hematopoietic stem cell transplantation.
Hu
Liang-ding
LD
Hematopoietic Stem Cell Transplantation Center of PLA, Affiliated Hospital of Chinese Academy of Military Medical Sciences, Beijing 100039, China. Huliangding@sohu.com
Chen
Hu
H
Jiang
Min
M
Li
Bo-tao
BT
Yu
Zhi-yong
ZY
Li
Yu-hang
YH
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007938:Leukemia / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D015375:Receptors, Interleukin-2