Gene expression in the cell cycle of human T lymphocytes: I. Predicted gene and protein networks.
The key genes involved in the cell cycle of human T lymphocytes were identified by iterative searches of gene-related databases, as derived also from DNA microarray experimentation, revealing and predicting interactions between those genes, assigning scores to each of the genes according to numbers of interaction for each gene weighted by significance of each interaction, and finally applying several types of clustering algorithms to genes basing on the assigned scores. All clustering algorithms applied, both hierarchical and K-means, invariably selected the same six "leader" genes involved in controlling the cell cycle of human T lymphocytes. Relations of the six genes to experimental data describing switching between stages of cell cycle of human T lymphocytes are discussed.
Sivozhelezov
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Fondazione Elba, Via delle Testuggini snc, 00100 Rome, Italy.
Giacomelli
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L
Tripathi
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S
Nicolini
C
C
D000465:Algorithms; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000032:analysis / Q000235:genetics; D016000:Cluster Analysis; D030541:Databases, Genetic; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods; D005796:Genes; D006801:Humans; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism*; D014158:Transcription, Genetic
D018797:Cell Cycle Proteins; D011506:Proteins