Two cases of intrahepatic cholangiocarcinoma detected after interferon therapy for chronic hepatitis C.
Recently, it has been suggested that hepatitis C virus infection plays a role in the pathogenesis of some intrahepatic cholangiocarcinomas (ICC). We describe two patients with small ICC detected after interferon therapy for chronic hepatitis C. Case 1 was diagnosed with ICC by preoperative biopsy and underwent anterior segmentectomy of the liver, while Case 2 was diagnosed with hepatocellular carcinoma preoperatively and the tumor was diagnosed as ICC after biopsy and microwave coagulonecrotic therapy. Both patients are in good health six months and five months, respectively, after operation. It is important to monitor carefully for ICC as well as hepatocellular carcinoma in patients with chronic hepatitis C, even when interferon therapy has been carried out, since the outcome of treatment for small ICC is favorable.
Kanazawa
Akishige
A
Department of Gastroenterological and Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Japan. m1644322@msic.med.osaka-cu.ac.jp
Kubo
Shoji
S
Hirohashi
Kazuhiro
K
Tanaka
Hiromu
H
Shuto
Taichi
T
Takemura
Shigekazu
S
Yamamoto
Takatsugu
T
Sakabe
Katsu
K
Nishiguchi
Shuhei
S
D000368:Aged; D000792:Angiography; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D001707:Biopsy, Needle; D017115:Catheter Ablation / Q000379:methods; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007150:Immunohistochemistry; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D009367:Neoplasm Staging; D011994:Recombinant Proteins; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins