title: Eosinophilic gastroenteritis with severe protein-losing enteropathy: successful treatment with budesonide.
abstract: We report the clinical, laboratory, endoscopic and histopathological findings in a 40-year-old woman with watery diarrhoea and hypoproteinaemia. Elevated alpha(1)-antitrypsin clearance confirmed massive protein-losing enteropathy. Gastroscopic and colonoscopic biopsies showed abundant infiltration of the small bowel wall with eosinophils in proximal duodenum and terminal ileum, respectively. These findings established the diagnosis of eosinophilic gastroenteritis. Both the inflammatory alterations and the severe intestinal protein loss were successfully treated with budesonide, a topically active corticosteroid preparation with controlled small bowel release. The case report illustrates that remission of protein-losing enteropathy secondary to eosinophilic gastroenteritis can be achieved with budesonide, thus supporting its use for this uncommon disease characterised by inflammatory intestinal lesions.
authors.affiliation: Department of Medicine III, University Hospital Aachen, Aachen University, RWTH, Pauwelsstrasse 30, Germany. siewert@rwth-aachen.de
authors.forename: E
authors.initials: E
authors.lastname: Siewert
authors.forename: F
authors.initials: F
authors.lastname: Lammert
authors.forename: P
authors.initials: P
authors.lastname: Koppitz
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Matern
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001706:Biopsy; D019819:Budesonide / Q000627:therapeutic use*; D004386:Duodenum / Q000473:pathology; D004802:Eosinophilia / Q000150:complications / Q000473:pathology; D005260:Female; D005759:Gastroenteritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007082:Ileum / Q000473:pathology; D011504:Protein-Losing Enteropathies / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000893:Anti-Inflammatory Agents; D019819:Budesonide