title: [The relationship between the concentration of TGF-beta1 in serum and its gene polymorphisms in CWP].
abstract: OBJECTIVE
  To study the relationship between the concentration of TGF-beta1, in serum and its gene polymorphisms in CWP.
  
  
  METHODS
  101 cases of coal worker's pneumoconiosis (CWP)were selected. And the peripheral vein blood samples were collected from them. The concentration of TGF-beta1 of their serum were detected with the TGF-beta1 ELISA kit. And their TGF-beta1 gene -509 site polymorphisms were analyzed with the polymerse chain reaction-restriction fragment length polymorphisms (PCR-RFLP) techniques.
  
  
  RESULTS
  The mean value of TGF-beta1, concentration in serum of T/T, C/T and C/C gene type group were 90 ml, 60 ml and 55.960 +/- 28.833 ng/ ml respectively. Significant differences were observed within the three groups (P<0.05). The differences of the mean value of TGF-beta1, concentration in serum in various work years groups, age groups and in the groups with different stage of pneumoconiosis were not significant (P > 0.05).
  
  
  CONCLUSIONS
  The correlative relationship between the concentration of transforming growth factor I (TGF-beta1) in serum and its gene -509 site polymorphisms might be occurring.
authors.affiliation: Department of Occupational Health, West China School of Public Health, Sichuan University, Chengdu 614401, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Yao
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Mian-Zhen
authors.initials: MZ
authors.lastname: Wang
authors.forename: Chang-Fu
authors.initials: CF
authors.lastname: Hao
authors.forename: Na
authors.initials: N
authors.lastname: Wang
mesh_terms: D003032:Coal Mining; D006801:Humans; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000235:genetics* / Q000378:metabolism; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D016212:Transforming Growth Factor beta / Q000097:blood* / Q000235:genetics*; D053773:Transforming Growth Factor beta1
chemical_list: C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1