title: Myxoid leiomyosarcoma of the liver.
abstract: This is the first report of a myxoid leiomyosarcoma arising in a cirrhotic liver. The tumor was resected from a 64-year-old man. On gross examination, it was soft and hemorrhagic. The tumor was composed of deceptively benign-looking smooth muscle cells with clear cytoplasm suspended in a myxoid stroma with foci of hemorrhage. Immunohistochemistry and electron microscopy confirmed that this was a smooth muscle cell neoplasm. The abundance of glycogen and ultrastructural signs of smooth muscle differentiation were considered consistent with an immature smooth muscle cell phenotype consistent with the diagnosis of myxoid leiomyosarcoma. Since myxoid leiomyosarcomas are aggressive tumors, it is important to recognize them histologically and also bear in mind that these tumors can occur even in unusual extrauterine locations such as a cirrhotic liver.
authors.affiliation: The Department of Pathology, The University of Zagreb School of Medicine, Zagreb, Croatia.
authors.forename: Mario
authors.initials: M
authors.lastname: Sicaja
authors.forename: Asraa
authors.initials: A
authors.lastname: Namiq
authors.forename: Jameson
authors.initials: J
authors.lastname: Forster
authors.forename: Ivan
authors.initials: I
authors.lastname: Damjanov
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor