title: Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium.
abstract: Multicentric reticulohistiocytosis (MRH) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although MRH is not strictly a paraneoplastic disease, one quarter of cases are malignancy related. We report a case of MRH with an initial remission followed by an acute exacerbation several years later heralding the clinical presentation of endometrial carcinoma. During this flareup a skin biopsy specimen revealed a diffuse dermal infiltrate composed of histiocytes with ground-glass cytoplasm and multiple atypical mitoses. Approximately 40% of the cells stained with the proliferation marker Ki-67. Treatment of endometrial carcinoma resulted in improvement of skin and joint symptoms, and a repeat biopsy specimen no longer demonstrated mitotic figures. These findings support a reactive and proliferative cause of MRH.
authors.affiliation: Department of Dermatology, Brown Medical School, Providence, Rhode Island 02903, USA.
authors.forename: Mohsin K
authors.initials: MK
authors.lastname: Malik
authors.forename: Laura
authors.initials: L
authors.lastname: Regan
authors.forename: Leslie
authors.initials: L
authors.lastname: Robinson-Bostom
authors.forename: Teddy D
authors.initials: TD
authors.lastname: Pan
authors.forename: Charles J
authors.initials: CJ
authors.lastname: McDonald
mesh_terms: D000368:Aged; D018292:Cystadenoma, Papillary / Q000150:complications*; D016889:Endometrial Neoplasms / Q000150:complications*; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000473:pathology; D006801:Humans