Long-term results of radical resection for locally advanced duodenal adenocarcinoma.
OBJECTIVE
Duodenal adenocarcinomas are uncommon tumors characterized by non-specific symptoms and late diagnosis. The objective of this study was to assess long-term results of locally advanced duodenal adenocarcinoma treated by surgical resection.


METHODS
A retrospective study, over a 10-year period, identified 9 patients (mean age 65 years) treated for duodenal carcinoma.


RESULTS
Out of nine patients who were treated for duodenal adenocarcinoma, 8 underwent R0 resection (5 pancreaticoduodenectomies, 1 total pancreaticoduodenectomy and 2 segmental duodenal resections). All of them had tumor of stage II or III according to TNM classification. Median follow-up was 104 months (range 25 to 185). Five patients had lymph node metastases (stage III) at the time of surgery. Two- and five-year survival rates were 100% and 75%, respectively for the whole group. No correlation between lymph node status and survival was found.


CONCLUSIONS
Radical surgical resection for locally advanced duodenal adenocarcinomas provides good long-term results in terms of patient survival, even for N1 tumors (stage III).
Bucher
Pascal
P
Clinic of Visceral and Transplantation Surgery, Department of Surgery University Hospital Geneva, Switzerland. Pascal.Bucher@hcuge.ch
Gervaz
Pascal
P
Morel
Philippe
P
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D004379:Duodenal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D016577:Pancreaticoduodenectomy / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment; D012812:Sigmoidoscopy / Q000379:methods; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome