Pharmacokinetic applications of capillary electrophoresis: a review on recent progress.
This article covers recent publications from 2003 to 2005 on the subject of pharmacokinetic applications of CE. Many analytical methods were validated and more importantly, they were shown to have sufficient sensitivities to access pharmacokinetic data on different models. Because of unique advantages, such as simplified sample preparation methods, small sample amount required, high separation power, and speedy analysis, CE-based assays were found to gain popularity not only as a second method but also as a major method for many pharmacokinetic studies.
Sung
Wang-Chou
WC
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan.
Chen
Shu-Hui
SH
D000818:Animals; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D010599:Pharmacokinetics