Low prevalence of premature ovarian failure in women given reduced-intensity conditioning regimens for hematopoietic stem-cell transplantation.
A survey was done to determine the prevalence of premature ovarian failure among female transplant patients. Within the 109 patients who replied, premature ovarian failure was found to be less common among women given reduced-intensity conditioning regimens (37.5%) than among those given high-dose conditioning regimens (79%) for hematopoietic stem-cell transplantation (p=0.007).
Cheng
Yee Chung
YC
Saliba
Rima M
RM
Rondón
Gabriela
G
Giralt
Sergio A
SA
Lu
Karen H
KH
Bodurka
Diane C
DC
Gershenson
David M
DM
Champlin
Richard E
RE
Ueno
Naoto T
NT
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015995:Prevalence; D016649:Primary Ovarian Insufficiency / Q000453:epidemiology / Q000209:etiology*; D011832:Radiation Injuries / Q000453:epidemiology / Q000209:etiology; D011795:Surveys and Questionnaires; D019172:Transplantation Conditioning / Q000009:adverse effects* / Q000379:methods; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation / Q000009:adverse effects
D000970:Antineoplastic Agents