title: CARD games between virus and host get a new player.
abstract: A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD-CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Johnson
authors.forename: Michael
authors.initials: M
authors.lastname: Gale
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D014777:Virus Diseases / Q000201:enzymology* / Q000821:virology*
chemical_list: D020169:Caspases