title: Renal tubular dysgenesis associated with in utero exposure to Nimuselide.
abstract: Maternal ingestion of the selective cyclo-oxygenase-2 (COX-2) inhibitor Nimuselide has been reported to be associated with the development of oligohydramnios and neonatal renal failure in some cases. We report a case of neonatal renal failure associated with maternal ingestion of Nimuselide in the third trimester of pregnancy. The neonate presented with metabolic acidosis and non-oliguric renal failure on the second day of life. The renal histopathology showed evidence of renal tubular dysgenesis. The child continues to have elevated serum creatinine and hypertension at 10 months of age.
authors.affiliation: Division of Nephrology, B.J. Wadia Hospital for Children and Research Centre, Mumbai, India. dr_usali@yahoo.com
authors.forename: Uma Sankari
authors.initials: US
authors.lastname: Ali
authors.forename: Sheila
authors.initials: S
authors.lastname: Khubchandani
authors.forename: Parmanand
authors.initials: P
authors.lastname: Andankar
authors.forename: Shashank
authors.initials: S
authors.lastname: Parekhji
authors.forename: Vishal
authors.initials: V
authors.lastname: Dubhalish
authors.forename: Bhavna
authors.initials: B
authors.lastname: Padhye
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007684:Kidney Tubules / Q000002:abnormalities*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D051437:Renal Insufficiency / Q000139:chemically induced*; D013449:Sulfonamides / Q000009:adverse effects*
chemical_list: D016861:Cyclooxygenase Inhibitors; D013449:Sulfonamides; C012655:nimesulide