Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis.
Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 microg ml(-1), which was higher than the usual therapeutic concentration (1-5 microg ml(-1)), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.
Park
Yoon Jeong
YJ
Craniomaxillofacial Reconstructive Science Major, Dental Research Institute, College of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, 110-749, Seoul, Korea.
Lee
Jue Yeon
JY
Yeom
Hey Ri
HR
Kim
Kyung Hwa
KH
Lee
Sang Chul
SC
Shim
In Kyoung
IK
Chung
Chong Pyoung
CP
Lee
Seung Jin
SJ
D020341:Absorbable Implants; D002214:Capsules / Q000008:administration & dosage / Q000737:chemistry; D004058:Diffusion; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D007267:Injections; D008911:Minocycline / Q000008:administration & dosage* / Q000737:chemistry*; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D011134:Polysaccharides / Q000737:chemistry*; D016896:Treatment Outcome
D002214:Capsules; D004343:Drug Implants; D011134:Polysaccharides; D008911:Minocycline