The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux.
ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub-group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti-microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux.
Reyes
Christopher L
CL
Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, CB105, La Jolla, CA 92137, USA.
Ward
Andrew
A
Yu
Jodie
J
Chang
Geoffrey
G
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000502:physiology*; D018360:Crystallography, X-Ray; D006868:Hydrolysis; D010599:Pharmacokinetics; D011487:Protein Conformation; D021381:Protein Transport; D013379:Substrate Specificity
D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; C079726:MsbA protein, Bacteria; D000255:Adenosine Triphosphate