title: Prevalence of decreased kidney function in Chinese adults aged 35 to 74 years.
abstract: BACKGROUND
  Chronic kidney disease (CKD) is a major public health burden in Western countries but little is known about its impact in developing countries. We estimated the prevalence and absolute burden of CKD in the general adult population in China.
  
  
  METHODS
  A cross-sectional survey was conducted in a nationally representative sample of 15,540 Chinese adults aged 35 to 74 years in 2000 and 2001. Serum creatinine was measured using the modified kinetic Jaffe reaction method at a central laboratory calibrated to the Cleveland Clinic Foundation laboratory. Glomerular filtration rate (GFR) was estimated using the simplified equation developed by the Modification of Diet in Renal Disease study. CKD was defined as an estimated GFR <60 mL/min/1.73m2.
  
  
  RESULTS
  Overall, the age-standardized prevalences of GFR 60 to 89, 30 to 59, and <30 mL/min/1.73m2 were 39.4%, 2.4%, and 0.14%, respectively, in Chinese adults aged 35 to 74 years. The overall prevalence of CKD (GFR <60 mL/min/1.73m2) was 2.53%, representing 11,966,653 persons (1.31% or 3,185,330 men and 3.82% or 8,781,323 women). The age-specific prevalence of CKD was 0.71%, 1.69%, 3.91%, and 8.14% among persons 35 to 44, 45 to 54, 55 to 64, and 65 to 74 years old, respectively. The age-standardized prevalence of CKD was similar in urban (2.60%) and rural (2.52%) residents but was higher in south China (3.05%) than in north China (1.78%) residents.
  
  
  CONCLUSIONS
  Although the prevalence of CKD in China was relatively low, the population absolute burden is substantial. These data warrant a national program aimed at detection, prevention, and treatment of CKD in China.
authors.affiliation: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA. jchen@tulane.edu
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Rachel P
authors.initials: RP
authors.lastname: Wildman
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: John W
authors.initials: JW
authors.lastname: Kusek
authors.forename: Monique
authors.initials: M
authors.lastname: Spruill
authors.forename: Kristi
authors.initials: K
authors.lastname: Reynolds
authors.forename: Donghai
authors.initials: D
authors.lastname: Liu
authors.forename: L Lee
authors.initials: LL
authors.lastname: Hamm
authors.forename: Paul K
authors.initials: PK
authors.lastname: Whelton
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006977:Hypertension, Renal / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000208:ethnology*
chemical_list: D003404:Creatinine