title: 1,2,4,5-Tetraoxacycloalkanes: synthesis and antimalarial activity.
abstract: In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.
authors.affiliation: Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. toratora@chem.eng.osaka-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Masuyama
authors.forename: J-M
authors.initials: JM
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Nojima
authors.forename: H-S
authors.initials: HS
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Wataya
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans
chemical_list: D000962:Antimalarials; D003516:Cycloparaffins