Molecular mechanisms of modified sensitivity of the adenylate cyclase signaling system to biogenic amines during streptozotocin-induced diabetes.
We demonstrated changes in the sensitivity of the adenylate cyclase signaling system to biogenic amines (adrenoceptor agonists and serotonin) underwent a change in skeletal muscles of rats with 30-day streptozotocin-induced diabetes. Isoproterenol had a less significant stimulatory effect on adenylate cyclase in diabetic rats. Hormonal signals via Gi proteins were suppressed in animals with diabetes, which determined a greater stimulatory effect of norepinephrine and serotonin on adenylate cyclase. Hormones less significantly increased guanosine triphosphate-binding activity of G proteins in diabetic rats, which reflects the impairment of their functional coupling with receptors.
Shpakov
A O
AO
Laboratory of Molecular Endocrinology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
Kuznetsova
L A
LA
Plesneva
S A
SA
Pertseva
M N
MN
D000262:Adenylyl Cyclases / Q000502:physiology*; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D051960:GTP-Binding Protein alpha Subunit, Gi2 / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D018342:Receptors, Adrenergic, beta-1 / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*
D001679:Biogenic Amines; D010446:Peptide Fragments; D018342:Receptors, Adrenergic, beta-1; D012701:Serotonin; D019204:GTP-Binding Proteins; D051960:GTP-Binding Protein alpha Subunit, Gi2; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D009638:Norepinephrine