title: Cancer-related symptom assessment in Russia: validation and utility of the Russian M. D. Anderson Symptom Inventory.
abstract: This multicenter cross-sectional study (n=226) validated the Russian-language M. D. Anderson Symptom Inventory (MDASI-R) in Russian cancer patients with hematological malignancies or solid tumors. The Russian-language Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36-R) also was used for validation. Factor analysis found three underlying constructs for symptom items--general, treatment-related, and affective symptoms--with Cronbach alphas of 0.86, 0.68, and 0.90, respectively. Convergent validity was established by comparing MDASI-R items with SF-36-R subscales. The MDASI-R detected significant differences in symptom severity and interference levels by performance status, supporting known-group validity. The most prevalent symptoms were fatigue, sleep disturbance, pain, sadness, and poor appetite; 53% of the sample reported one to four moderate-to-severe symptoms (>or=5 on 0-10 scale). Symptoms interfered most with work and general activity. Medical professionals underestimated the severity of pain, fatigue, and distress. The MDASI-R is valid and reliable for measuring symptom severity and interference in Russian cancer patients.
authors.affiliation: National Cancer Research and Treatment Center, St. Petersburg, Russia.
authors.forename: Maria O
authors.initials: MO
authors.lastname: Ivanova
authors.forename: Tatyana I
authors.initials: TI
authors.lastname: Ionova
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Kalyadina
authors.forename: Olga S
authors.initials: OS
authors.lastname: Uspenskaya
authors.forename: Anton V
authors.initials: AV
authors.lastname: Kishtovich
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
authors.forename: Tito R
authors.initials: TR
authors.lastname: Mendoza
authors.forename: Andrei
authors.initials: A
authors.lastname: Novik
authors.forename: Charles S
authors.initials: CS
authors.lastname: Cleeland
authors.forename: Xin S
authors.initials: XS
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006306:Health Surveys; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000523:psychology*; D015203:Reproducibility of Results; D012426:Russia; D012720:Severity of Illness Index