title: Immunosuppressive treatment of chronic non-viral myocarditis.
abstract: Inflammatory cardiomyopathy defined as myocarditis associated with cardiac dysfunction, represents a main cause of heart failure. Despite the improvement of diagnostic techniques, a specific standardized treatment of myocarditis is not yet available. The immunohistochemical detection of myocardial HLA up-regulation has been demonstrated useful in the identification of a sub-group of autoimmune inflammatory dilated cardiomyopathy (DCM) in part susceptible to immunosuppression. Recently, in a retrospective study, we defined the virologic and immunologic profile of responders and non-responders to immunosuppressive therapy of active lymphocytic myocarditis and chronic heart failure in patients who had failed to benefit from conventional supportive treatment. Non-responders were characterized by high prevalence (85%) of viral genomes in the myocardium and no detectable cardiac autoantibodies in the serum. Conversely, 90% of responders were positive for autoantibodies, while only 3 (15%) of them presented viral particles at PCR analysis on frozen endomyocardial tissue. With regard to the type of virus involved in non-responders, enterovirus, adenovirus, or their combination was associated with the worst clinical outcome. Hepatitis C virus (HCV) was the only viral agent of our series associated with detectable cardiac autoantibodies, suggesting a relevant immunomediated mechanism of damage by HCV and explaining the relief of myocardial inflammation after immunosuppressive treatment. The assessment of virologic and immunologic features of patients with biopsy-proven inflammatory cardiomyopathy may allow us to identify a specific treatment leading to recovery of cardiac function.
authors.affiliation: Cardiology Department, Catholic University Largo A Gemelli 8, Rome, Italy. biocard@rm.unicatt.it
authors.forename: A
authors.initials: A
authors.lastname: Frustaci
authors.forename: M
authors.initials: M
authors.lastname: Pieroni
authors.forename: C
authors.initials: C
authors.lastname: Chimenti
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009205:Myocarditis / Q000188:drug therapy / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents