title: Developmental outcome of epilepsy surgery in tuberous sclerosis complex.
abstract: In Tuberous sclerosis complex (TSC), neurological dysfunction, usually in association with epilepsy, is responsible for the greatest degree of disease-related disability. Epilepsy surgery is increasingly recognized as a therapeutic option given the often medication-resistant nature of the disease. Seven subjects with medically refractory epilepsy associated with TSC, who underwent surgery at a tertiary care epilepsy center and in whom both preoperative and postoperative neuropsychological data were available, were examined. The Vineland Adaptive Behavior Scales, and in one case, the WISC-III were utilized. Postoperatively, the composite standard scores declined in six of the seven subjects, although for the most part this decline was quite modest (8 points or less in 5/6 subjects). The mean overall developmental/intellectual quotients were comparable across assessments (preoperative M = 55, SD = 20.3; postoperative M = 49 SD = 16.6). Good outcomes appeared to be related to seizure relief. Age estimates of developmental level indicated developmental progress in the majority of subjects in the current sample, and may yield greater clinical information for individuals with developmental delay than do standard scores.
authors.affiliation: Clinical Neuropsychology, NYU Comprehensive Epilepsy Center, New York 10016, USA. charles.zaroff@med.nyu.edu
authors.forename: Charles M
authors.initials: CM
authors.lastname: Zaroff
authors.forename: Chris
authors.initials: C
authors.lastname: Morrison
authors.forename: Nina
authors.initials: N
authors.lastname: Ferraris
authors.forename: Howard L
authors.initials: HL
authors.lastname: Weiner
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Miles
authors.forename: Orrin
authors.initials: O
authors.lastname: Devinsky
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology; D002675:Child, Preschool; D003131:Combined Modality Therapy; D002658:Developmental Disabilities / Q000209:etiology*; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications / Q000601:surgery*
chemical_list: D000927:Anticonvulsants