title: Secretion and expression of epithelial markers supports the biliary origin of solitary nonparasitic cyst of the liver in infancy.
abstract: Solitary nonparasitic cyst of the liver (SNPCL) is rare in children. Although there are several hypotheses regarding the pathogenesis, the true origin of SNPCL remains unknown. The authors present an infant with a huge SNPCL in whom the epithelial markers, CA19-9, DU-PAN-2, and SPan-1, were elevated in the serum and cystic fluid. The presence of CA19-9 and DU-PAN-2 was shown by immunohistochemistry in the cystic epithelia. These indicate that the classical idea of biliary origin of SNPCL is supported.
authors.affiliation: Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, Koshigaya, Saitama 343-8555, Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Otani
authors.forename: Hajime
authors.initials: H
authors.lastname: Takayasu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ishimaru
authors.forename: Kaori
authors.initials: K
authors.lastname: Okamura
authors.forename: Junko
authors.initials: J
authors.lastname: Yamagishi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ikeda
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D001659:Biliary Tract / Q000473:pathology*; D018395:CA-19-9 Antigen / Q000097:blood; D003560:Cysts / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008107:Liver Diseases / Q000473:pathology* / Q000601:surgery; D008297:Male
chemical_list: D000951:Antigens, Neoplasm; D018395:CA-19-9 Antigen; C042317:DU-PAN-2 antigen, human; C059729:pancreatic associated antigen, SPan-1