Novel dimeric alkaloids from the roots of Thalictrum atriplex.
Two new bisbenzylisoquinoline alkaloids, neothalfine (1) and thaliatrine (2), together with three known dimeric alkaloids, thalifaberine, thalistine, and thalirecebine, have been isolated from the roots of Thalictrum atriplex Finet et Gagnep. Their structures have been established by spectroscopy. Compound 1 showed in vitro antiplatelet aggregation activities.
Gao
G-Y
GY
Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, 100094, Beijing, China.
Chen
S-B
SB
Chen
S-L
SL
Wang
L-W
LW
Xiao
P-G
PG
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007546:Isoquinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D031949:Thalictrum / Q000737:chemistry*
D000470:Alkaloids; D007546:Isoquinolines