title: Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis.
abstract: Four HIV-1-infected patients presented with unusual clinical manifestations in the course of disseminated histoplasmosis, including liver abscesses, compressive lymphadenitis, intestinal obstruction, uveitis and arthritis within a median of 45 days after initiation of highly active antiretroviral therapy (HAART). They had a median increase of 106 CD4 cells/mul and granulomas with caseation in three. Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome.
authors.affiliation: Department of Infectious and Tropical Diseases, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Breton
authors.forename: Homa
authors.initials: H
authors.lastname: Adle-Biassette
authors.forename: Audrey
authors.initials: A
authors.lastname: Therby
authors.forename: Jacky
authors.initials: J
authors.lastname: Ramanoelina
authors.forename: Laurence
authors.initials: L
authors.lastname: Choudat
authors.forename: François
authors.initials: F
authors.lastname: Bissuel
authors.forename: Michel
authors.initials: M
authors.lastname: Huerre
authors.forename: Françoise
authors.initials: F
authors.lastname: Dromer
authors.forename: Bertrand
authors.initials: B
authors.lastname: Dupont
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006660:Histoplasmosis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole