A reticular variant of elastolytic giant cell granuloma.
An 80-year-old man presented with a distinctive reticular form of elastolytic giant cell granuloma (EGCG). This represents a rare subset of EGCG, thus belonging to a larger group of granulomatous skin diseases with poorly understood pathogenesis. The patient exhibited numerous erythematous to brownish, sharply demarcated patches of reticulate appearance with partial central atrophy and nonelevated margins, which involved the trunk and especially chest, shoulders, upper back and arms. Skin biopsy revealed a granulomatous infiltrate with multinucleate histiocytes containing remnants of elastic fibres in conjunction with a significant loss of elastic fibres throughout the dermis. There is little published information on treatment, which remains unsatisfactory.
Hinrichs
R
R
Department of Dermatology and Allergology, University of Ulm, Germany.
Weiss
T
T
Peschke
E
E
Scharffetter-Kochanek
K
K
Weber
L
L
D000369:Aged, 80 and over; D020405:Dermis / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D017211:Treatment Failure