title: [Cocaine and trisomy 8 associated with prenatal diagnosis of corpus callosum agenesis].
abstract: We report the case of a newborn presenting an agenesis of corpus callosum (ACC) discovered in the prenatal period and initially related to cocaine exposure during the first trimester of gestation. The cytogenetic analysis revealed a trisomy 8 mosaicism. The putative role of prenatal cocaine exposure and mosaicism for chromosome 8 in ACC are discussed. This report emphasizes the specific analysis of chromosome 8 by using fluorescence in situ hybridization as a complement to routine cytogenetic analysis for prenatal diagnosis of ACC.
authors.affiliation: Service de Réanimation Néonatale.
authors.forename: E
authors.initials: E
authors.lastname: Gonzales
authors.forename: L
authors.initials: L
authors.lastname: Caeymaex
authors.forename: A
authors.initials: A
authors.lastname: Aboura
authors.forename: M
authors.initials: M
authors.lastname: Vial
authors.forename: J
authors.initials: J
authors.lastname: De Laveaucoupet
authors.forename: P
authors.initials: P
authors.lastname: Labrune
authors.forename: G
authors.initials: G
authors.lastname: Tachdjian
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000235:genetics; D061085:Agenesis of Corpus Callosum; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009030:Mosaicism; D011247:Pregnancy; D014314:Trisomy / Q000235:genetics*
chemical_list: D003042:Cocaine