Hematological parameters in wistar rats in conditions of stress and treatment with heparin.
The effects on hematological measures of emotional tension arising during the formation of food-procuring behavior in a multiple-choice maze and in conditions of pain (injection of 0.85% physiological saline i.m., 0.3 ml, daily for five days) were studied in Wistar rats. Physiological saline and training of intact animals led to increases in RBC volume and mean corpuscular hemoglobin content, accompanied by significant increases in plasma corticosterone levels. At the same time, neither heparin (standard unfractionated heparin, Serva, doses of 64 and 640 IU/kg, daily for five days) nor training of heparinized rats produced any changes in these measures. The high levels of organization of the acquired behavior and the working capacity seen in heparinized rats were evidence for improvements in both the associative properties of conditioned reflex activity and the mechanisms supporting stable reproduction of the acquired habit. After administration of heparin, rats lost all types of manifestation reflecting psychoemotional tension as generally seen in animals in the active (administration of physiological saline) and passive (intact rats) controls.
Kondashevskaya
M V
MV
State Science Research Institute of Human Morphology, Russian Academy of Medical Sciences, Functional Morphology of Stress Group, 3 Tsyurupa Street, 117418 Moscow, Russia.
Mkhitarov
V A
VA
D000704:Analysis of Variance; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D002755:Choice Behavior / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004911:Erythrocyte Volume; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D006493:Heparin / Q000627:therapeutic use*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology
D000925:Anticoagulants; D006454:Hemoglobins; D006493:Heparin; D003345:Corticosterone