Second-generation K(ATP) channel openers.
This review discusses structural aspects of second-generation K(ATP) channel openers (KCOs), which exhibit improved tissue-selectivity. Their therapeutic profile is debated with main focus on cardiac ischemia, asthma, and urinary incontinence.
Mannhold
Raimund
R
Department of Laser Medicine, Molecular Drug Research Group, Heinrich-Heine-Universitat, Universitatsstrasse 1, 40225 Dusseldorf, Germany. mannhold@uni-duesseldorf.de
Leclerc
Gérard
G
D018528:ATP-Binding Cassette Transporters / Q000819:agonists* / Q000502:physiology*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D006801:Humans; D054086:KATP Channels; D017202:Myocardial Ischemia / Q000188:drug therapy; D009928:Organ Specificity; D024661:Potassium Channels, Inwardly Rectifying / Q000819:agonists* / Q000502:physiology*; D012137:Respiratory System / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects
D018528:ATP-Binding Cassette Transporters; D018927:Anti-Asthmatic Agents; D054086:KATP Channels; D024661:Potassium Channels, Inwardly Rectifying; C092520:uK-ATP-1 potassium channel