Effect of drugs with various mechanisms of action on propulsive activity of the small intestine.
We studied the effect of drugs with various mechanisms of action on propulsive activity of the small intestine in healthy rats. Blockade of the major inhibitory influences realized via nonadrenergic noncholinergic inhibitory effector neurons was not followed by stimulation of intestinal transit. Propulsive activity of the small intestine increased upon treatment with drugs, whose effects are realized via acetylcholine or acetylcholine and serotonin.
Tropskaya
N S
NS
N. V. Sklifosovsky Institute of Emergency Medicine, Moscow. ntropskaya@mail.ru
Popova
T S
TS
Solov'eva
G I
GI
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D018679:Cholinergic Agonists / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D017615:Enteric Nervous System / Q000187:drug effects*; D005070:Evans Blue; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D018679:Cholinergic Agonists; D002800:Cholinesterase Inhibitors; D018492:Dopamine Antagonists; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D009388:Neostigmine; D005070:Evans Blue; D011433:Propranolol