Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis.
Four HIV-1-infected patients presented with unusual clinical manifestations in the course of disseminated histoplasmosis, including liver abscesses, compressive lymphadenitis, intestinal obstruction, uveitis and arthritis within a median of 45 days after initiation of highly active antiretroviral therapy (HAART). They had a median increase of 106 CD4 cells/mul and granulomas with caseation in three. Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome.
Breton
Guillaume
G
Department of Infectious and Tropical Diseases, Hôpital Bichat-Claude Bernard, Paris, France.
Adle-Biassette
Homa
H
Therby
Audrey
A
Ramanoelina
Jacky
J
Choudat
Laurence
L
Bissuel
François
F
Huerre
Michel
M
Dromer
Françoise
F
Dupont
Bertrand
B
Lortholary
Olivier
O
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006660:Histoplasmosis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole