Recovery and brain reorganization after stroke in adult and aged rats.
Stroke is a prevalent and devastating disorder, and no treatment is currently available to restore lost neuronal function after stroke. One unique therapy that improves recovery after stroke is neutralization of the neurite inhibitory protein Nogo-A. Here, we show, in a clinically relevant model, improved functional recovery and brain reorganization in the aged and adult rat when delayed anti-Nogo-A therapy is given after ischemic injury. These results support the efficacy of Nogo-A neutralization as treatment for ischemic stroke, even in the aged animal and after a 1-week delay, and implicate neuronal plasticity from unlesioned areas of the central nervous system as a mechanism for recovery.
Markus
Tiffanie M
TM
Neuroscience & Aging Institute, Loyola University Chicago, Maywood, IL, USA.
Tsai
Shih-Yen
SY
Bollnow
Melanie R
MR
Farrer
Robert G
RG
O'Brien
Timothy E
TE
Kindler-Baumann
Diana R
DR
Rausch
Martin
M
Rudin
Markus
M
Wiessner
Christoph
C
Mir
Anis K
AK
Schwab
Martin E
ME
Kartje
Gwendolyn L
GL
D000367:Age Factors; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002545:Brain Ischemia / Q000503:physiopathology / Q000628:therapy; D004195:Disease Models, Animal; D009185:Myelin Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology; D016501:Neurites / Q000502:physiology; D009473:Neuronal Plasticity; D000070798:Nogo Proteins; D051381:Rats; D020127:Recovery of Function; D020521:Stroke / Q000503:physiopathology* / Q000628:therapy*
D000911:Antibodies, Monoclonal; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603197:Rtn4 protein, rat