Increasing post-event plasma thrombomodulin level associates with worse outcome in survival of acute coronary syndrome.
OBJECTIVE
We seek to evaluate the association of serial plasma soluble thrombomodulin (TM) change and outcome in survivals of acute coronary syndrome (ACS).


BACKGROUND
Plasma TM is a marker of endothelial damage. Elevated cross-sectional TM level has been found to be associated with worse outcome in survivals of acute myocardial infarction (MI). However, the association of serial TM change with ACS is not clear.


METHODS
In 47 survivals of ACS [39 males; age, 64.7+/-9.3 years; 15 unstable angina (UA), 32 acute MI], plasma soluble TM and serum high sensitivity C-reactive protein (hs-CRP) levels are measured at index ACS and at 3-month follow-up. Using hierarchical cluster analysis, patients are classified into ascending (n=29) and descending group (n=18) according to the change in TM level. Composite study end-point is recurrent UA, MI and sudden cardiac death (SCD).


RESULTS
The magnitude of change of plasma soluble TM is not related to demographic characteristics, diagnosis and pattern of revascularization. The change of TM level in ascending and descending group is 1.80+/-1.13 and -1.73+/-0.48 ng/ml (p<0.001), respectively. There is no significantly difference in demographic characteristics, diagnosis and pattern of revascularization between both groups. The mean hs-CRP levels at index ACS and at 3-months follow-up are also not statistically different between two groups. At 6-month follow-up, 6 patients in ascending group reach end-point (1 SCD, 1 UA, and 4 MIs), however, no patient in descending group suffers from subsequent event (p=0.044). After a mean follow-up of 317 days (range, 60 to 541 days), 9 (19%) patients reach end-point. Kaplan-Meier survival analysis reveals that increasing plasma TM predicts worse clinical outcome (hazard ratio=0.13, log-transformed 95% confidence interval 0.03 to 0.48, p=0.0224 by the log-rank test).


CONCLUSIONS
Increasing plasma TM level associates with worse outcome in patients surviving ACS.
Chan
Shih-Hung
SH
Cardiovascular Division, Department of Internal Medicine, National Cheng-Kung University Medical Center, 138 Sheng Li Road, 70428, Tainan City, Taiwan, ROC. cvdrchan@ms28.hinet.net
Chen
Jyh-Hong
JH
Li
Yi-Heng
YH
Lin
Li-Jen
LJ
Tsai
Liang-Miin
LM
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D001026:Coronary Artery Bypass; D003430:Cross-Sectional Studies; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D018180:Thrombomodulin / Q000097:blood*; D016896:Treatment Outcome
D015415:Biomarkers; D018180:Thrombomodulin; D002097:C-Reactive Protein