title: Reconciling subject differences in recruitment to clinical trials and clinical practice.
abstract: The special interest group on Reconciling Subject Differences was centered around the issue that the results from randomized clinical trials do not predict response to therapies in clinical practice, and around the hypothesis that this might be explained by differences in subjects selected for clinical trials compared to those treated in routine practice.
authors.affiliation: University of Manchester, Manchester, UK.
authors.forename: Kimme L
authors.initials: KL
authors.lastname: Hyrich
authors.forename: Deborah P M
authors.initials: DP
authors.lastname: Symmons
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Silman
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D015510:Clinical Medicine; D006801:Humans; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic; D012923:Social Class; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D014409:Tumor Necrosis Factor-alpha