title: Mucormycosis spondylodiscitis after lumbar disc puncture.
abstract: Vertebral osteomyelitis due to mucormycosis is a rare but fulminant and fatal disease. Only one case has been reported in literature, with postmortem diagnosis. The present paper reports a female case of mucormycosis spondylodiscitis and vertebral osteomyelitis after lumbar disc puncture and radio frequency nucleoplasty. She subsequently underwent two surgical debridements, continuous local irrigation and drainage, together with local and systemic Amphotericin B treatments. The infection was controlled 4 months after the second debridement; however, there was no improvement in the neurological function at the most recent follow-up, 16 months after the surgery. The experience of this patient, though a single case, supports early recognition, surgical debridement, systemic and local antifungal treatment, closed irrigation and drainage as the keys to successful treatment.
authors.affiliation: Department of Spine Surgery, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Guohua
authors.initials: G
authors.lastname: Lü
authors.forename: Yijun
authors.initials: Y
authors.lastname: Kang
authors.forename: Zeming
authors.initials: Z
authors.lastname: Ma
authors.forename: Chang
authors.initials: C
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Haisheng
authors.initials: H
authors.lastname: Li
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D003646:Debridement; D015299:Discitis / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000382:microbiology*; D008875:Middle Aged; D009091:Mucormycosis / Q000209:etiology* / Q000628:therapy; D010019:Osteomyelitis / Q000209:etiology / Q000628:therapy; D013129:Spinal Puncture / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents