Malignant rhabdoid tumour of the kidney: report of a case showing focal glomeruloid differentiation.
A five-month-old male baby presented with an abdominal mass which was found on computerised tomography (CT) to be involving the left kidney. Nephrectomy and histopathological study showed morphological featues of a malignant rhabdoid tumour. The tumour cells stained strongly for cytokeratin and epithelial membrane antigen and less intensely for vimentin. Electron microscopy revealed concentric whorled arrays of intermediate filaments within the tumour cell cytoplasm. The child was put on post-operative chemotherapy and radiotherapy but developed bilateral lung metastases and died three months after surgery.
Jayaram
G
G
Department of Pathology, Faculty of Medicine, University of Malaya, 59100 Kuala Lumpur, Malaysia.
Looi
L M
LM
D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007633:Keratins / Q000032:analysis; D007678:Kidney Glomerulus / Q000473:pathology; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins