Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients.
Optimal sampling times are found for a study in which one of the primary purposes is to develop a model of the pharmacokinetics of itraconazole in patients with cystic fibrosis for both capsule and solution doses. The optimal design is expected to produce reliable estimates of population parameters for two different structural PK models. Data collected at these sampling times are also expected to provide the researchers with sufficient information to reasonably discriminate between the two competing structural models.
Waterhouse
Timothy H
TH
School of Physical Sciences, The University of Queensland, Brisbane, Australia. thw@maths.uq.edu.au
Redmann
Stefanie
S
Duffull
Stephen B
SB
Eccleston
John A
JA
D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D002214:Capsules; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008954:Models, Biological; D019999:Pharmaceutical Solutions; D012494:Sampling Studies
D000935:Antifungal Agents; D002214:Capsules; D019999:Pharmaceutical Solutions; D017964:Itraconazole