[The epidemiology of Helicobacter pylori resistance to antibiotics in Beijing].
OBJECTIVE
To investigate the prevalence of Helicobacter pylori (H. pylori) resistance to metronidazole, clarithromycin and amoxicillin in Beijing.


METHODS
H. pylori strains were cultured from the gastric biopsy samples obtained from 159 patients with upper abdominal symptoms by gastroendoscopy. Minimal inhibitory concentrations of antibiotics were determined by E-test method.


RESULTS
The resistance rates of H. pylori to metronidazole and clarithromycin in Beijing were 36.0% (18/50) and 10.0% (5/50) in 1999-2000, 43.1% (47/109) and 18.3% (20/109) in 2001-2002, respectively. H. pylori resistance to both metronidazole and clarithromycin were 10.0% (5/50) in 1999-2000 and 14.7% (16/109) in 2001-2002. Only one strain was found resistant to amoxicillin in 49 patients.


CONCLUSIONS
The resistance rates of H. pylori to metronidazole and clarithromycin were increased in Beijing in recent years. The strains resistant to amoxicillin were rare.
Cheng
Hong
H
Department of Internal Medicine, First Hospital of Bejing University, Beijing 100034, China.
Hu
Fu-lian
FL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China; D017291:Clarithromycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005260:Female; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008875:Middle Aged; D013276:Stomach Ulcer / Q000382:microbiology
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000658:Amoxicillin; D017291:Clarithromycin