[Preventive surgery for familial adenomatous polyposis coli].
Familial adenomatous polyposis coli (FAP) may not be considered a single disease entity with standardized guidelines for operative treatment. However, prophylactic colectomy after the manifestation of polyps but prior to the development of colorectal cancer is essential. The optimal timing of prophylactic surgery remains a clinical decision taken independently of mutation analysis. In case of the classic FAP phenotype, restorative proctocolectomy and ileal pouch-anal anastomosis is the procedure of choice. The development of reliable guidelines for attenuated FAP variants requires further evidence from clinical studies on surgical strategy and the advantages of prophylactic surgery over regular endoscopic screening with removal of polyps.
Kadmon
M
M
Abteilung Allgemein-, Visceral- und Unfallchirurgie, Chirurgische Universitätsklinik Heidelberg. martina_kadmon@med.uni-heidelberg.de
D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003082:Colectomy; D039021:Colonic Pouches; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D016737:Proctocolectomy, Restorative; D013997:Time Factors