Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: dual agonists for human peroxisome proliferator-activated receptor alpha and delta.
Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) alpha and delta, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.
Kasuga
Jun-ichi
J
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Hashimoto
Yuichi
Y
Miyachi
Hiroyuki
H
D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D047493:PPAR alpha / Q000819:agonists*; D047494:PPAR delta / Q000819:agonists*; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D047493:PPAR alpha; D047494:PPAR delta; D010666:Phenylpropionates