title: Lack of prophylactic effect of incadronate on skeletal lesions associated with implants of prostate cancer.
abstract: OBJECTIVE
  To evaluate prophylactic effects of bisphosphonate (BP) on skeletal lesions induced by prostate cancer (CaP).
  
  
  METHODS
  Incadronate, a third-generation BP, was administered weekly for 4 weeks, with or without 4-week pre-administration, to rats whose calvaria had been inoculated with syngeneic CaP tissue.
  
  
  RESULTS
  The transplanted CaP grew up and caused bone resorption with osteoblastic changes regardless of incadronate treatment. Although decrease in bone resorption accompanied by reduced number of osteoclasts was shown by incadronate administration, pre-administration had no additional inhibitory effect on bone destruction and Ki-67 labeling indices of CaP cells were not altered.
  
  
  CONCLUSIONS
  These results indicate that application of BP alone is not sufficient to prevent skeletal lesions due to CaP in patients with high risk of bone metastases although it is useful in inhibition of cancer-induced bone resorption with osteoblastic changes.
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan. uropatho@ybb.ne.jp
authors.forename: Atsuya
authors.initials: A
authors.lastname: Hikosaka
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Futakuchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ogiso
authors.forename: Shugo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kohri
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shirai
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D004164:Diphosphonates / Q000627:therapeutic use*; D008297:Male; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D017211:Treatment Failure
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; C071542:cimadronate