title: Pharmacologic agents in fracture healing.
abstract: Bone fractures are a known risk of athletic participation and can result in significant lost playing time. A variety of medications have been investigated in animal studies regarding their effects on fracture healing. Parathyroid hormone and the bisphosphonates may have future uses in the prevention and treatment of athletic-related stress fractures and acute fractures. Nonsteroidal anti-inflammatory drugs have been implicated in effecting fracture healing in some animal models, but little clinical evidence supports these findings. Large randomized clinical trials are needed to further delineate the role of these and other drugs and their effects on fracture healing.
authors.affiliation: Vanderbilt Sports Medicine, Medical Center East, Nashville, TN 37232, USA. michael.koester@vanderbilt.edu
authors.forename: Michael C
authors.initials: MC
authors.lastname: Koester
authors.forename: Kurt P
authors.initials: KP
authors.lastname: Spindler
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001265:Athletic Injuries / Q000188:drug therapy*; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects; D002118:Calcium / Q000627:therapeutic use; D019587:Dietary Supplements; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000627:therapeutic use; D013178:Sports Medicine / Q000379:methods / Q000639:trends; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004164:Diphosphonates; D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium