title: Reaction properties of catalytic antibodies encapsulated in organo substituted SiO2 sol-gel materials.
abstract: Catalytic antibodies (38C2 and 84G3) were encapsulated in hybrid organic-inorganic sol-gel powder prepared from tetraethoxysilane (TEOS) and organoalkoxysilanes, then used to catalyze enantioselective aldol reactions. Sol-gel immobilization enhanced antibody stability with respect to the effect of temperature and organic solvent concentration.
authors.affiliation: National Institute of Advanced Industrial Science and Technology (AIST), 2266-98 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-8560, Japan. katsuya-kato@aist.go.jp
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kato
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
authors.forename: Sindhu
authors.initials: S
authors.lastname: Seelan
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tomita
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yokogawa
mesh_terms: D017151:Antibodies, Catalytic / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D004800:Enzymes, Immobilized / Q000737:chemistry*; D005634:Fructose-Bisphosphate Aldolase / Q000737:chemistry / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry / Q000276:immunology; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D020034:Silicone Gels / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013696:Temperature
chemical_list: D017151:Antibodies, Catalytic; D002214:Capsules; D004800:Enzymes, Immobilized; D007140:Immunoglobulin Fab Fragments; D012821:Silanes; D020034:Silicone Gels; D012997:Solvents; C040733:tetraethoxysilane; D012822:Silicon Dioxide; C109536:antibody aldolase; D005634:Fructose-Bisphosphate Aldolase