[Aminoguanidine decreases the brain damage in rats neonatally exposed to hypoxic-ischemic influences].
Seven days old rats (n=30) were divided into five groups (6 animals in each). Three groups underwent hypoxic-ischemic event (occlusion of right common carotid artery lasting 2,5 hours and breathing with 8% oxygen and 92% of nitrogen mixture). The rats of the fifth group, after completion of hypoxic-ischemic impact and following a daily reoxygenation (for three days) were injected (i/p) with selective inhibitor of nitric oxide inducible synthase, in a dose of 300 mg/kg. The rats of the fourth group were injected with 150 mg/kg of the selective inhibitor of nitric oxide synthase -- aminoguanidine (150 mg/kg); the animals of the third group were injected with saline (50 ml). The second group contained the shame-operated animals and the first group -- intact (control) animals. An intensity of local cerebral blood flow in fronto-parietal area of neocortex was measured by means of hydrogen clearance technique. In the right hemisphere (ipsilateral to occluded common carotid artery) of the animals of the third group significant decrease, and in contralateral hemisphere (left) temporal increase of CBF did occur. Administration of aminoguanidine prevents high degree of brain damage observed in the control group of animals.
Khurtsiia
M Sh
MSh
Pavlenishvili
I V
IV
Agladze
N Dzh
ND
Mitagvariia
N P
NP
Beklaia
G L
GL
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000254:growth & development; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use*; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D006146:Guanidines; D018696:Neuroprotective Agents; D052247:Nitric Oxide Synthase Type II; C004479:pimagedine