title: Synthesis of deserpidine from reserpine.
abstract: The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.
authors.affiliation: Istituto CNR per la Sintesi Organica e Fotoreattività ISOF, Area della Ricerca di Bologna, Via P., Gobetti 101, 40129 Bologna, Italy. G.Varchi@isof.cnr.it
authors.forename: Greta
authors.initials: G
authors.lastname: Varchi
authors.forename: Arturo
authors.initials: A
authors.lastname: Battaglia
authors.forename: Cristian
authors.initials: C
authors.lastname: Samorì
authors.forename: Eleonora
authors.initials: E
authors.lastname: Baldelli
authors.forename: Bruno
authors.initials: B
authors.lastname: Danieli
authors.forename: Gabriele
authors.initials: G
authors.lastname: Fontana
authors.forename: Andrea
authors.initials: A
authors.lastname: Guerrini
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
mesh_terms: D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011926:Rauwolfia / Q000737:chemistry; D012110:Reserpine / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D012110:Reserpine; C100104:deserpidine