Targeting the stromal fibroblasts: a novel approach to melanoma therapy.
Classically, cancer is thought of as a genetic disease, where the step-wise acquisition of mutations initiates and drives progression. More recent thinking posits that, although cancers are initiated through genetic mutation, progression is often the result of dynamic interactions between the tumor cells and their surrounding environment.
Smalley
Keiran S M
KS
The Wistar Institute, Philadelphia, PA 19104, USA. ksmalley@wistar.org
Lioni
Mercedes
M
Herlyn
Meenhard
M
D002448:Cell Adhesion; D002450:Cell Communication; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D015603:Keratinocytes / Q000502:physiology*; D008545:Melanoma / Q000276:immunology* / Q000628:therapy*; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic; D010641:Phenotype; D012878:Skin Neoplasms / Q000276:immunology* / Q000628:therapy*; D017154:Stromal Cells; D016212:Transforming Growth Factor beta / Q000502:physiology
D016212:Transforming Growth Factor beta