title: Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia.
abstract: A new acetophenone derivative, melicopone, along with twenty-nine known compounds has been isolated from the root wood of Melicope semecarpifolia. The structure of this new compound was determined using spectral analyses. The compound oxynitidine isolated in this study adds the Melicope genus to the benzo[c]phenanthridine-containing members chemotaxonomically. Three isolates were cytotoxic in P-388 and HT-29 cell lines, and anti-platelet aggregation activities were shown for 10 known compounds.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Taiwan, Republic of China.
authors.forename: Hsueh-Chun
authors.initials: HC
authors.lastname: Chou
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
authors.forename: Tur-Fu
authors.initials: TF
authors.lastname: Huang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001547:Benzaldehydes / Q000302:isolation & purification / Q000494:pharmacology; D019817:Benzoic Acid / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011804:Quinolines / Q000302:isolation & purification / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000970:Antineoplastic Agents; D001547:Benzaldehydes; D003374:Coumarins; D005419:Flavonoids; D017705:Lignans; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D011804:Quinolines; C459623:ayanin; C507344:melicopone; D019817:Benzoic Acid