Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Jordan.
Molecular screening for glucose-6-phosphate (G6PD) mutations in two Jordanian populations revealed six different mutations and higher incidences of G6PD deficiency and G6PD A- (376A-->G + 202G-->A) mutation in Jordan Valley than in the Amman area. These observations may be explained by historically higher rates of malaria and African ancestral origins, respectively.
Karadsheh
Naif S
NS
Moses
Linda
L
Ismail
Said I
SI
Devaney
Joseph M
JM
Hoffman
Eric
E
D000222:Adaptation, Physiological; D000328:Adult; D000349:Africa / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics; D018740:Genetic Heterogeneity; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology; D008297:Male
D005954:Glucosephosphate Dehydrogenase; C482910:glucose-6-phosphate dehydrogenase A-