title: Hodgkin lymphoma developing in a 4.5-year-old girl with hyper-IgE syndrome.
abstract: The authors report a case of Hodgkin lymphoma developing in a 4.5-year-old female child with hyper-IgE syndrome. This is one of the few cases of malignancy reported in this syndrome. The patient had severe atopic dermatitis, asthma, recurrent pneumonia, recurrent skin infections, and growth retardation. Immunologic evaluation revealed a high level of immunoglobulin E (7000 IU/mL) and peripheral eosinophilia. She was found to have normal values for serum IgG, IgM, IgA, WBC chemotaxis, serum complement function and normal sweat chloride test. The development of fatal Hodgkin lymphoma in this patient with hyper-IgE syndrome may suggest an increased risk for developing premature malignancies in hyper-IgE syndrome, although the precise immunologic defect is still unknown.
authors.affiliation: Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Kashef
authors.forename: Sara
authors.initials: S
authors.lastname: Kashef
authors.forename: Farhad
authors.initials: F
authors.lastname: Handjani
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007589:Job Syndrome / Q000150:complications* / Q000175:diagnosis; D008171:Lung Diseases / Q000188:drug therapy / Q000209:etiology; D009503:Neutropenia
chemical_list: D000970:Antineoplastic Agents