title: The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms.
abstract: P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
authors.affiliation: Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Twinbrook 2, 12441 Parklawn Drive, Rockville, Maryland 20852, USA. asaxena@mail.jnu.ac.in
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Saxena
authors.forename: Kavita
authors.initials: K
authors.lastname: Singh
authors.forename: Hua-Poo
authors.initials: HP
authors.lastname: Su
authors.forename: Michael M
authors.initials: MM
authors.lastname: Klein
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Stowers
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Saul
authors.forename: Carole A
authors.initials: CA
authors.lastname: Long
authors.forename: David N
authors.initials: DN
authors.lastname: Garboczi
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry* / Q000378:metabolism*; D000954:Antigens, Surface / Q000737:chemistry* / Q000378:metabolism*; D009033:Culicidae / Q000469:parasitology*; D017780:Malaria Vaccines / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D010966:Plasmodium vivax / Q000737:chemistry* / Q000254:growth & development* / Q000378:metabolism; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary
chemical_list: D000953:Antigens, Protozoan; D000954:Antigens, Surface; D017780:Malaria Vaccines; C121473:Pvs25 protein, P vivax; C121474:Pvs28 protein, P vivax