The puzzle of somatostatin: action, receptors, analogues and therapy.
The scientific search for the revelation of the multiple physiological aspects of somatostatin has already begun. Investigators have managed to clarify many pathophysiological processes that have been influenced or regulated by somatostatin. The focus of future research seems to be the therapeutic application of this accumulated knowledge. The aim of this study is to collect the available information on the action, receptors and use of somatostatin analogues in human tissues. For this reason findings were based on Internet search and complete studies with abstracts written in English. A special mention on the influence of somatostatin on the immune system and inflammatory bowel disease is also included.
Panteris
V
V
Department of Gastroenterology, Tzaneion General Hospital of Piraeus, Greece. kresson@panafonet.gr
Karamanolis
D G
DG
D015551:Autoimmunity / Q000187:drug effects; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D017481:Receptors, Somatostatin / Q000502:physiology*; D012680:Sensitivity and Specificity; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*
D017481:Receptors, Somatostatin; D013004:Somatostatin