title: Studies on antidiarrhoeal activity of an extract of wine from Jacquez grapes in mice.
abstract: The present study was designed to verify the antidiarrhoeal effects of a lyophilized extract of wine from Jacquez grapes (Ord. Rhamnales; Fam. Vitaceae; Sp. Vitis aestivalis M.-cinerea E. x Vitis vinifera L.), studying its influence on castor oil-induced diarrhoea and enteropooling, and on gastrointestinal transit (measured by a charcoal marker) in mice. The pre-treatment of the animals with the JWE (Jacquez wine extract) produced a significant inhibition against castor oil induced-diarrhoea and intestinal fluid accumulation; furthermore the extract significantly decreased the propulsive movement of the charcoal meal. These findings suggest a potential beneficial use of the JWE in the treatment of diarrhoeal diseases.
authors.affiliation: Department Farmaco-Biologico, University of Messina, Villaggio SS Annunziata, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Vitali
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Bonina
authors.forename: Antonella
authors.initials: A
authors.lastname: Saija
authors.forename: Antonio
authors.initials: A
authors.lastname: Tomaino
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Fonte
authors.forename: Claudia
authors.initials: C
authors.lastname: Pennisi
authors.forename: Beatrice
authors.initials: B
authors.lastname: Tita
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology / Q000627:therapeutic use*; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D027843:Vitis; D014920:Wine
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil