Chemical genetics: Drug screens in Zebrafish.
High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets.
den Hertog
Jeroen
J
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584, Utrecht, CT, The Netherlands. hertog@niob.knaw.nl
D000818:Animals; D030801:Animals, Genetically Modified; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008954:Models, Biological; D008957:Models, Genetic; D016296:Mutagenesis; D010597:Pharmacogenetics / Q000379:methods*; D018675:Toxicity Tests; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism* / Q000502:physiology*