Physicochemical properties of valsartan and the effect of ethyl alcohol, propylene glycol and pH on its solubility.
The aqueous solubility and partition coefficient of valsartan were determined at room temperature. The effect of ethyl alcohol, propylene glycol and pH on its solubility was also investigated. It was found that both solvents increased the solubility of the drug in water. The solubilizing power of ethyl alcohol was found to be higher than that of propylene glycol. Valsartan solubility was also observed to increase at high pH values and its lipophilicity wasdemonstrated by the high positive value of the logarithm of partition coefficient.
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DMI Inc., 86 N. Main Street, Wharton, NJ 07885, USA.
D000959:Antihypertensive Agents / Q000737:chemistry*; D002138:Calibration; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D000431:Ethanol; D006863:Hydrogen-Ion Concentration; D019946:Propylene Glycol; D012015:Reference Standards; D012995:Solubility; D012997:Solvents; D013777:Tetrazoles / Q000737:chemistry*; D013816:Thermodynamics; D014633:Valine / Q000031:analogs & derivatives* / Q000737:chemistry; D000068756:Valsartan
D000959:Antihypertensive Agents; D012997:Solvents; D013777:Tetrazoles; D000431:Ethanol; D019946:Propylene Glycol; D000068756:Valsartan; D014633:Valine