title: Detection of altered secondary lymphoid-tissue chemkine responsiveness in Balb/c mice infected with Schistosoma mansoni.
abstract: To determine the extent to which Balb/c mice splenic T cells were affected by S. mansoni infection, this study aims to investigate the ability of the T cells to produce interferon (IFN)-&, and their chemotactic ability at 7 weeks post-infection. The splenic T cells were capable of producing levels of IFN-& comparable with splenic T cells from naive mice. However, the T cells exhibited altered chemotactic activity, as evidenced by an inability to respond to secondary lymphoid-tissue chemokine (SLC/CCL21). Although no difference in chemokine expression was found between the spleens of infected versus control mice, chemokine production was greater in the livers of infected versus control mice. Collectively, these data indicate that Balb/c mice with 7-wk S. mansoni infection possess splenic T cells with altered chemotactic activity and that the alterations may be a consequence of granulomatous response in the liver.
authors.affiliation: Department of Parasitology, Faculty of Medicine, University of Zagazig, Egypt.
authors.forename: Mohsen M
authors.initials: MM
authors.lastname: Hassan
authors.forename: Hany
authors.initials: H
authors.lastname: Afify
authors.forename: Aly
authors.initials: A
authors.lastname: el-Dairouty
authors.forename: Mohsen
authors.initials: M
authors.lastname: Shalaby
authors.forename: Khalid
authors.initials: K
authors.lastname: Assal
authors.forename: M El-Salahy M M
authors.initials: Mel-S
authors.lastname: Monib
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: el-Kadi
mesh_terms: D000818:Animals; D054421:Chemokine CCL21; D019742:Chemokines, CC / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression; D006801:Humans; D008099:Liver / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: C515478:CCL21 protein, human; C515479:Ccl21c protein, mouse; D054421:Chemokine CCL21; D019742:Chemokines, CC