title: Lobular carcinoma of the breast metastatic to the uterus in a patient under adjuvant anastrozole therapy.
abstract: This is the first report of breast carcinoma metastatic to the endometrium in a patient on adjuvant anastrozole therapy. We report a case of metastatic lobular carcinoma of the breast in a 63-year-old patient on adjuvant anastrozole therapy for 8 months. She was asymptomatic and metastatic endometrium was diagnosed after transvaginal ultrasound revealed suspicious findings along with elevated Ca 15-3 levels. As further work up showed no other metastatic sites her uterus was taken out along with her ovaries and pelvic lymph nodes. Uterine metastases should be kept in mind in asymptomatic patients on anastrozole therapy.
authors.affiliation: Department of Obstetrics & Gynecology, Baskent University School of Medicine, Seyhan- Adana, Turkey. serkanli@tnn.net
authors.forename: Serkan
authors.initials: S
authors.lastname: Erkanli
authors.forename: Fazilet
authors.initials: F
authors.lastname: Kayaselcuk
authors.forename: Esra
authors.initials: E
authors.lastname: Kuscu
authors.forename: Filiz
authors.initials: F
authors.lastname: Bolat
authors.forename: Hakan
authors.initials: H
authors.lastname: Sakalli
authors.forename: Ali
authors.initials: A
authors.lastname: Haberal
mesh_terms: D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000188:drug therapy* / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D016889:Endometrial Neoplasms / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D009570:Nitriles / Q000627:therapeutic use*; D010052:Ovariectomy; D014230:Triazoles / Q000627:therapeutic use*; D014463:Ultrasonography; D014621:Vagina / Q000000981:diagnostic imaging
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D018396:Mucin-1; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D007633:Keratins