Three new podocarpane-type diterpenoids from callus of Securinega suffruticosa.
Three new podocarpane-type diterpenoids, 3beta,12-dihydroxy-13-methyl-6,8,11,13-podocarpatetraen (1), 3beta,12-dihydroxy-13-methyl-5,8,11,13-podocarpatetraen-7-one (2), and 1-(7-hydroxy-2,6-dimethyl-1-naphthyl)-4-methyl-3-pentanone (3) (20(10-->5)-abeo-4,5-seco-5(10),6,8,11,13-podocarpapentaen-3-one) were isolated from callus of Securinega suffruticosa. The structures were elucidated by spectroscopic methods. Compounds 1, 2, and 3 showed cytotoxic activity against five human cancer cell lines (A549, BEL 7402, BGC-823, HCT-8, A2780).
Yuan
Wei
W
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Lu
Ziming
Z
Liu
Ying
Y
Meng
Chao
C
Cheng
Ke-Di
KD
Zhu
Ping
P
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D002236:Carbohydrate Conformation; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013778:Tetrazolium Salts; D013844:Thiazoles
C507962:1-(7-hydroxy-2,6-dimethyl-1-naphthyl)-4-methyl-3-pentanone; C507961:3beta,12-dihydroxy-13-methyl-5,8,11,13-podocarpatetraen-7-one; C507960:3beta,12-dihydroxy-13-methyl-6,8,11,13-podocarpatetraen; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue