Two new triterpenoid saponins from Symplocos chinensis.
Two new triterpenoid saponins, symplocososides X (1) and Y (2) have been isolated from the roots of Symplocos chinensis, and their structures elucidated as 21beta-O- cinnamoyl-22alpha-O-(2-methylbutanoyl)-15alpha, 16alpha, 28-trihydroxyolean-12-ene-3beta-O-[beta-D-glucopyranosyl (1 --> 2)]-alpha-L-arabinofuranosyl (1 --> 4)-beta-D-glucuronopyranoside (1) and 21beta-O-cinnamoyl-22alpha-O-(2-methylbutanoyl)-15alpha, 16alpha, 28-trihydroxyolean-12-ene-3beta-O-(3-O-acetyl)-[beta-D-glucopyranosyl (1 --> 2)]-alpha-L-arabinofuranosyl (1 --> 4)-beta-D-glucuronopyranoside (2) by spectral and chemical methods. Their antitumor activities have also been tested.
Zhao
J
J
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Yu
S-S
SS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D005562:Formazans; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D005562:Formazans; D012503:Saponins; D013778:Tetrazolium Salts; D014315:Triterpenes; C079782:MTT formazan