title: Viscoelasticity of pediatric blood and its implications for the testing of a pulsatile pediatric blood pump.
abstract: Red blood cell hematocrit, aggregation and deformability, and plasma protein concentration influence the viscosity and elasticity of whole blood. These parameters affect the flow properties, especially at low shear rates (< 50 s(-1)). In particular, we have previously shown that the viscoelasticity of fluid affects the inlet filling characteristics and regions of flow separation in small pulsatile blood pumps. Although the viscosity of pediatric blood has been thoroughly studied, its elasticity has not been previously measured. Here we present the viscosity and elasticity of pediatric blood against shear rate for hematocrits from 19-56, measured using an oscillatory rheometer. There is little effect of patient age on blood viscoelasticity. A statistical analysis showed that when compared at constant hematocrit, blood from adult and pediatric patients had similar viscoelastic properties. We present blood analog solutions, as a function of hematocrit, constructed on the basis of the pediatric measurements. Flow field results for viscoelastic analogs of 20, 40 and 60% hematocrit and a Newtonian analog will be compared in the initial, in vitro testing of the Penn State pediatric blood pump, to determine the importance of incorporating a viscoelastic analog into the desigh interaction.
authors.affiliation: Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Long
authors.forename: Akif
authors.initials: A
authors.lastname: Undar
authors.forename: Keefe B
authors.initials: KB
authors.lastname: Manning
authors.forename: Steven
authors.initials: S
authors.lastname: Deutsch
mesh_terms: D001783:Blood Flow Velocity; D001809:Blood Viscosity / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D006353:Heart-Assist Devices; D006400:Hematocrit; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011673:Pulsatile Flow; D012016:Reference Values; D012044:Regression Analysis