title: Regional cerebral blood flow change in a case of Alzheimer's disease with musical hallucinations.
abstract: We examined alteration of regional cerebral blood flow (rCBF) in a case of Alzheimer's disease (AD) patient with musical hallucination. To detect regions related to musical hallucination, single-photon emission computed tomography (SPECT) imaging of the patient and nine sex, age, and cognitive function-matched AD patients without delusions and hallucinations were compared using statistical parametric mapping 99 (SPM99). In comparison with controls, the patient had increased rCBF in left temporal regions and left angular gyrus. This profile could be relevant to the neuroanatomical basis of musical hallucinations.
authors.affiliation: Department of Neuropsychiatry, Ehime University School of Medicine, Toon city, Ehime 791-0295, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Mori
authors.forename: Manabu
authors.initials: M
authors.lastname: Ikeda
authors.forename: Ryuji
authors.initials: R
authors.lastname: Fukuhara
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakata
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Nestor
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tanabe
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D006212:Hallucinations / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009146:Music; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon