title: Acanthosis nigricans: clinical predictor of abnormal glucose tolerance in Asian women with polycystic ovary syndrome.
abstract: The aim of this retrospective study was to assess whether acanthosis nigricans is a predictive factor for abnormal glucose tolerance (AGT) in Asian women with polycystic ovary syndrome (PCOS). Data from the record forms and electronic form of 121 PCOS women who consecutively attended the Reproductive Endocrinology and Infertility Unit were reviewed. In accordance with the unit's guidelines, all women received a physical examination, had anthropometric measurements taken and underwent as a 75-g oral glucose tolerance test after diagnosis. Their age, body mass index (BMI) and waist/hip ratio (WHR) was 29.1+/-6.1 years, 27.4+/-6.8 kg/m2 and 0.84+/-0.6 (mean+/-standard deviation), respectively. The prevalence of AGT was 42.9%, with 1.6% having impaired fasting glucose, 32.3% having impaired glucose tolerance and 9.1% having type 2 diabetes mellitus. The PCOS women with acanthosis nigricans had significantly higher BMI, WHR, fasting glucose, 2-h post-load glucose, fasting insulin, 2-h post-load insulin and prevalence of AGT compared with those without acanthosis nigricans. By logistic regression analysis, acanthosis nigricans and WHR were independent predictors for AGT, with an odds ratio (95% confidence interval) of 2.7 (1.1-7.1) and 10.1 (1.8-20.7), respectively. In conclusion, acanthosis nigricans was demonstrated as a predictive factor for AGT in Asian women with PCOS.
authors.affiliation: Reproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Kandapa
authors.initials: K
authors.lastname: Charnvises
authors.forename: Sawaek
authors.initials: S
authors.lastname: Weerakiet
authors.forename: Yada
authors.initials: Y
authors.lastname: Tingthanatikul
authors.forename: Surapee
authors.initials: S
authors.lastname: Wansumrith
authors.forename: Suwannee
authors.initials: S
authors.lastname: Chanprasertyothin
authors.forename: Aram
authors.initials: A
authors.lastname: Rojanasakul
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications / Q000453:epidemiology*; D000328:Adult; D000886:Anthropometry; D044466:Asian People; D005260:Female; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D008499:Medical Records; D016017:Odds Ratio; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000453:epidemiology*; D011237:Predictive Value of Tests; D015995:Prevalence; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology; D049629:Waist-Hip Ratio