From egg to embryo: a peripatetic journey.
The recent surge of interest in oocyte development has been spurred in large part by the increasing implementation of assisted reproductive technologies (ART) to treat human infertility. What is becoming apparent is that 'egg quality' is a primary factor in the success of ART (Sauer 1998), and yet we know virtually nothing about the molecular signature of a 'high quality' oocyte, i.e., an oocyte that is capable of maturing, being fertilized and supporting development to term. We are gaining marked insights, however, into how sperm activate eggs and the changes in gene expression that accompany preimplantation development. Nevertheless, embryo culture is known to effect gene expression (Rinaudo & Schultz 2004), the long-term consequences of which are only recently being unmasked. This review will briefly highlight these topics that were presented during the Biennial Joint Meeting of the UK Fertility Societies at Warwick University in April 2005.
Schultz
Richard M
RM
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA. rschultz@sas.upenn.edu
D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D002869:Chromosome Aberrations; D005260:Female; D005306:Fertilization / Q000502:physiology*; D005307:Fertilization in Vitro / Q000009:adverse effects; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D008297:Male; D008322:Mammals / Q000502:physiology*; D008540:Meiosis / Q000502:physiology*; D009865:Oocytes / Q000166:cytology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects