Herpesvirus interference with virus-specific antibodies: bridging antibodies, internalizing antibodies, and hiding from antibodies.
Herpesviruses have developed different tools to thwart efficient antibody-dependent neutralisation and lysis of virions and elimination of infected cells. This overview will briefly summarize different of these tools, including (i) viral Fc receptors and the resulting process of antibody bridging, (ii) internalization of individual viral proteins and clustered antibody-antigen complexes from the plasma membrane of infected cells, and (iii) directed egress of virus particles to sites of intimate cell-cell contact that are difficult to access for antibodies.
Favoreel
Herman W
HW
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Van Minnebruggen
Geert
G
Van de Walle
Gerlinde R
GR
Ficinska
Jolanta
J
Nauwynck
Hans J
HJ
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002450:Cell Communication / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D006564:Herpesviridae / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D008562:Membrane Glycoproteins; D011961:Receptors, Fc; D014759:Viral Envelope Proteins