Plasma values of oxidants and antioxidants in acute brain hemorrhage: role of free radicals in the development of brain injury.
The levels of oxidants xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA) and of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione reductase (GRD) were determined in plasma within 24 h after onset of hemorrhagic stroke in 17 patients (9 men and 8 women, aged 60.7+/-11.5 yr) and in 20 healthy controls (12 men and 8 women, aged 62.5+/-8.3 yr). Compared to controls, the plasma SOD and total superoxide scavenger activities (TSSA) were significantly lower and the NO levels were significantly higher among the stroke patients. XO showed a slight, nonsignificant increase in the patients, but the levels of MDA, NSSA, GRD, and GSH-Px did not show any significant differences between the two groups. The hemorrhage volume was negatively correlated with the initial score of the Glasgow Coma Scale and a positive correlation with lethal outcome, but it did not correlate significantly with any of the measured parameters. The results suggest that free radicals might play a role in the development of brain injury following brain hemorrhage.
Aygul
Recep
R
Department of Neurology, Medical Faculty, Ataturk University, Erzurum, Turkey.
Demircan
Berna
B
Erdem
Fuat
F
Ulvi
Hizir
H
Yildirim
Abdulkadir
A
Demirbas
Fatih
F
D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D002543:Cerebral Hemorrhage / Q000097:blood*; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D005609:Free Radicals / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D016877:Oxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D005980:Glutathione Reductase