Stimulation of cell component of the immune response activates exploratory behavior in senescence accelerated OXYS rats.
Suppression of the cell component of the immune system and open-field behavior developing in OXYS rats by the age of 3 months are regarded as manifestations of accelerated aging. Stimulation of cell-mediated immune response with BCG vaccine caused a dose-dependent increase of orientation and exploratory activity of OXYS rats in the open field test to virtually the same level as in Wistar rats.
Markova
E V
EV
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. evgeniya_markova@mail.ru
Kozlov
V A
VA
Trofimova
N A
NA
Kolosova
N G
NG
D000375:Aging / Q000502:physiology*; D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007107:Immune System / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D009043:Motor Activity; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar
D001500:BCG Vaccine