title: Deep brain stimulation of the internal pallidum in multiple system atrophy.
abstract: We describe the outcome of deep brain stimulation of the internal pallidum in a 57-year old patient with multiple system atrophy. Although the prominent dystonic features of this patient were markedly attenuated post-operatively, the outcome was to be considered unfavourable. There was a severe increase in akinesia resulting in overall decrease of mobility in limbs as well as in the face. As a result, the patient was anarthric and displayed dysphagia. A laterality effect of stimulation on oro-facial movements was demonstrated. The patient died 7 months post-operatively. This report adds to the growing consensus that multiple system atrophy patients are unsuitable candidates for deep brain stimulation.
authors.affiliation: Department of Neurology, Gent University Hospital, Belgium. patrick.santens@ugent.be
authors.forename: Patrick
authors.initials: P
authors.lastname: Santens
authors.forename: Santens
authors.initials: S
authors.lastname: Patrick
authors.forename: Kristl
authors.initials: K
authors.lastname: Vonck
authors.forename: Vonck
authors.initials: V
authors.lastname: Kristl
authors.forename: Miet
authors.initials: M
authors.lastname: De Letter
authors.forename: De Letter
authors.initials: DL
authors.lastname: Miet
authors.forename: Katya
authors.initials: K
authors.lastname: Van Driessche
authors.forename: Van Driessche
authors.initials: VD
authors.lastname: Katya
authors.forename: Anne
authors.initials: A
authors.lastname: Sieben
authors.forename: Sieben
authors.initials: S
authors.lastname: Anne
authors.forename: Jacques
authors.initials: J
authors.lastname: De Reuck
authors.forename: De Reuck
authors.initials: DR
authors.lastname: Jacques
authors.forename: Dirk
authors.initials: D
authors.lastname: Van Roost
authors.forename: Van Roost
authors.initials: VR
authors.lastname: Dirk
authors.forename: Paul
authors.initials: P
authors.lastname: Boon
authors.forename: Boon
authors.initials: B
authors.lastname: Paul
mesh_terms: D046690:Deep Brain Stimulation; D004421:Dystonia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*