Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
A series of dinaphtho[1,2-b;2',3'-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.
Lee
Kee-In
KI
Division of Bio-Organic Science, Korea Research Institute of Chemical Technology, Daejeon 305-353, Republic of Korea.
Park
Youmie
Y
Park
Su-Jin
SJ
Hwang
Jung-Hwan
JH
Lee
Sung-Jin
SJ
Kim
Gun-Do
GD
Park
Woo-Kyu
WK
Lee
Sunghou
S
Jeong
Daeyoung
D
Kong
Jae-Yang
JY
Kang
Hee-Kyoung
HK
Cho
Heeyeong
H
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D005663:Furans; D009285:Naphthoquinones; D011799:Quinazolines; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor