title: Chronic sternal osteomyelitis complicating primary manubriosternal septic arthritis.
abstract: We present a 40-year-old woman complaining of worsening chest pain. She was previously treated with a prolonged course of antibiotics for suspected sternal osteomyelitis. Radiological investigations were suggestive of ongoing inflammation within the manubriosternal joint. Formal surgical debridement yielded evidence corroborating the diagnosis although microbiological samples were negative. Prolonged empirical treatment with intravenous antibiotics leads to a complete resolution of symptoms. Primary culture-negative manubriosternal septic arthritis is rare, and suboptimal treatment, particularly if confused with other conditions such as synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome, compounds its considerable morbidity.
authors.affiliation: Department of Paediatric Surgery, John Radcliffe Hospital, Oxford, UK. sid261@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: A
authors.initials: A
authors.lastname: Sinha
authors.forename: K
authors.initials: K
authors.lastname: Nagarajah
authors.forename: E L
authors.initials: EL
authors.lastname: Oei
authors.forename: P
authors.initials: P
authors.lastname: Critchley
authors.forename: M A
authors.initials: MA
authors.lastname: McNally
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use; D002908:Chronic Disease; D003646:Debridement; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008371:Manubrium; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D011859:Radiography; D013249:Sternum
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone