On association between cortical 5-HT2A receptors and behavior in rats with experimental thyroid disturbances.
Thyroid hormones (TH) were hypothesized to affect behavior via neurotransmission alterations. The present study was aimed to reveal effects of chronic TH deficit and excess on some types of adaptive behavior (catalepsy, acoustic startle reflex, open-field performance), sexual arousal and cerebral 5-HT2A serotonin receptors of adult Wistar rats. Administration of thyroxine synthesis inhibitor, propylthiouracil (PTU, 50 mg/l, 28 days), in drinking water produced substantial decrease in plasma thyroxine level and body weight gain, attenuated significantly acoustic startle reflex amplitude, sexual motivation and plasma testosterone surge in response to receptive female introduction, increased predisposition to catalepsy without considerable effects on open-field performance. L-thyroxine treatment (T4, 0.5 mg/l, 28 days) caused significant plasma thyroxine augmentation, somatic growth retardation and disturbances in sexual but not in other types of behavior studied. TH dysfunctions markedly increased number of DOI-induced wet dog shakes reflecting high functional activity of 5-HT2A receptors without any effect on cortical 5-HT2A receptor mRNA level. The involvement of cerebral 5-HT2A receptors alterations at posttranslational level in mechanisms of TH effects on sexual arousal was suggested. The data attract particular attention to undesirable effects of PTU and L-thyroxine treatment on behavior.
Tikhonova
Maria A
MA
Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Lavrentyev Avenue, Novosibirsk, 630090, Russia.
Kulikov
Alexander V
AV
Lebedeva
Ekaterina I
EI
Barykina
Natalia N
NN
Amstislavskaya
Tamara G
TG
Popova
Nina K
NK
D000818:Animals; D001483:Base Sequence; D002375:Catalepsy; D002540:Cerebral Cortex / Q000378:metabolism*; D017931:DNA Primers; D005260:Female; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics / Q000378:metabolism*; D013216:Reflex, Startle; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012726:Sexual Behavior, Animal; D013959:Thyroid Diseases / Q000378:metabolism / Q000503:physiopathology*; D013974:Thyroxine / Q000097:blood
D017931:DNA Primers; D012333:RNA, Messenger; D044402:Receptor, Serotonin, 5-HT2A; D013974:Thyroxine