title: [Corneal intra-epithelial neoplasia (CIN). Treatment by combined excision and antimetabolite therapy].
abstract: METHODS
  We present two clinical cases of corneal intra-epithelial neoplasia defined histopathologically.
  
  
  CONCLUSIONS
  We sought to establish the importance of treatment with Mitomycin-C in two cases of corneal intra-epithelial neoplasia. The differential diagnosis was established based on the evolutionary character of the process, as well as specific histopathological aspects of these entities. In both cases, treatment with Mitomycin-C before, during and after surgery contributed to the decrease in the size of the lesion and to their cure without relapse.
authors.affiliation: Instituto Oftalmológico de Alicante VISSUM, Alicante, España. Laria@arsystel.com
authors.forename: C
authors.initials: C
authors.lastname: Laria-Ochaita
authors.forename: J L
authors.initials: JL
authors.lastname: Alió-y-Sanz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002278:Carcinoma in Situ / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003316:Corneal Diseases / Q000601:surgery / Q000628:therapy*; D005134:Eye Neoplasms / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin