title: New naphthoquinones, f13102A and B, from a fungus strain F-13102.
abstract: Deficiency of Fas-mediated apoptosis is one of the mechanisms involved in the immune evasion by tumors. Thus, it might be a practical approach for cancer treatment that Fas-mediated apoptosis in tumor cells is modified by drugs. In the course of screening, we have isolated two new naphthoquinones, f13102A and B, from the culture broth of fungus strain F-13102. Coumpound f13102A sensitizes Fas-resistant human lung adenocarcinoma A549 cells to apoptosis.
authors.affiliation: Drug Development Unit, Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kumagai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Someno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Naoto
authors.initials: N
authors.lastname: Kawamura
authors.forename: Kunio
authors.initials: K
authors.lastname: Isshiki
authors.forename: Daishiro
authors.initials: D
authors.lastname: Ikeda
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009285:Naphthoquinones; C507229:f13102A compound; C507230:f13102B compound