[Assessment of antioxidative enzymes activity and intensification of lipids peroxidation in asthmatic patients].
Chronic immunoallergic inflammatory reaction plays a key role in pathogenesis of asthma. Importance of free oxygen radicals in mechanism of chronic inflammatory process has been proved. Activity of two antioxidative enzymes: isoenzymes of superoxide dismutase (SOD), glutathione peroxidase (POX), and concentration of malondialdehyde (MDA) in serum and erythrocytes in asthmatics during exacerbation and improvement of disease were assessed. Disturbances in oxidative system in asthmatic patients have been observed. Lack of significant differences in antioxidative indexes between a period of exacerbation, not complicated by infection and a period of improvement indicates a pathophysiological role of chronic oxygen stress in asthma. It has been also shown that bacterial infection disturbs efficiency of antioxidative mechanisms.
Rogala
Barbara
B
Slaskiej Akademii Medycznej w Katowicach, Katedra i Klinika Chorób Wewnetrznych, Alergologii i Immunologii Klinicznej w Zabrzu.
Polaniak
Renata
R
Grzanka
Alicja
A
Ciesielska-Kopacz
Nelly
N
Birkner
Ewa
E
D000208:Acute Disease; D000328:Adult; D001249:Asthma / Q000097:blood / Q000201:enzymology*; D002908:Chronic Disease; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase