title: Facile and efficient postsynthetic tritium labeling method catalyzed by Pd/C in HTO.
abstract: [reaction: see text] We have developed a facile and efficient tritium labeling method using a Pd/C-HTO-H2 system. This method can provide multitritium-labeled compounds in highly diluted HTO under T2 gas-free conditions, and is environmentally benign since purification by silica gel column chromatography is not necessary, which causes a large quantity of radioactive waste such as silica gel and eluent.
authors.affiliation: Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu, 502-8585, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maegawa
authors.forename: Kosaku
authors.initials: K
authors.lastname: Hirota
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Tatematsu
authors.forename: Yukio
authors.initials: Y
authors.lastname: Mori
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
mesh_terms: D002384:Catalysis; D007553:Isotope Labeling / Q000379:methods*; D010165:Palladium; D014316:Tritium / Q000737:chemistry*
chemical_list: D014316:Tritium; D010165:Palladium