A simple and efficient approach to 1,3-polyols: application to the synthesis of cryptocarya diacetate.
A highly enantio- and stereoselective synthetic strategy for both syn- and anti-1,3-polyols has been developed. The sequence involves iterative Jacobsen's hydrolytic kinetic resolution (HKR), diastereoselective iodine-induced electrophilic cyclization, and ring-closing metathesis (RCM). This protocol has subsequently been utilized for the synthesis of cryptocarya diacetate, a natural product with broad range of biological activity.
Kumar
Pradeep
P
Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India. pk.tripathi@ncl.res.in
Gupta
Priti
P
Naidu
S Vasudeva
SV
D031369:Cryptocarya / Q000737:chemistry*; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*
D004852:Epoxy Compounds; D011108:Polymers; C024617:polyol