Two new triterpenes from the husks of Xanthoceras sorbifolia.
Two new triterpenes, 22-angeloyl-21-epoxyangeloylbarringtogenol C (1) and 21,22-diangeloyl-24-hydroxy-R(1)-barrigenol (2), and the known 21,22-diangeloyl-R(1)-barrigenol (3) were isolated from the husks of Xanthoceras sorbifolia Bunge. Their structures were elucidated based on detailed NMR analysis. Compounds 1 and 2 inhibited significantly the growth of cancer cell lines (A375-S2, HeLa) with IC(50) values ranging from 2.9 to 76.3 micromol/L.
Li
Zhan-Lin
ZL
Research Department of Natural Medicines, Shenyang Pharmaceutical University, Shenyang, PR China.
Li
Xian
X
Li
Lin-Hao
LH
Li
Ning
N
Yu
Ming
M
Meng
Da-Li
DL
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D029631:Sapindaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C507333:21,22-diangeloyl-24-hydroxy-R(1)-barrigenol R; C507345:21,22-diangeloyl-R(1)-barrigenol; C507334:22-angeloyl-21-epoxyangeloylbarringtogenol C; D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes