title: Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits.
abstract: Blood oxygenation level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method to assess changes in oxygen delivery to tissues. It was hypothesized that BOLD MR imaging can detect changes in rabbit VX2 liver tumor oxygenation after hepatic artery embolization with polyvinyl alcohol particles. In four discrete VX2 liver tumors, a statistically significant mean reduction in apparent transverse relaxation time was shown, from 55 milliseconds before embolization to 41 milliseconds after embolization (P < .01). This reduction corresponded to a decrease in hepatic tumor oxygenation. The use of BOLD MR imaging to monitor changes in hepatic tumor oxygenation after embolization is feasible. These functional MR imaging measurements of hypoxia may be targeted as an endpoint for therapy in future studies.
authors.affiliation: Department of Radiology, Northwestern University, Chicago, Illinois 60611, USA.
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Rhee
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Larson
authors.forename: Pottumarthi V
authors.initials: PV
authors.lastname: Prasad
authors.forename: Elizabette
authors.initials: E
authors.lastname: Santos
authors.forename: Kent T
authors.initials: KT
authors.lastname: Sato
authors.forename: Riad
authors.initials: R
authors.lastname: Salem
authors.forename: Jie
authors.initials: J
authors.lastname: Deng
authors.forename: Tatjana
authors.initials: T
authors.lastname: Paunesku
authors.forename: Gayle E
authors.initials: GE
authors.lastname: Woloschak
authors.forename: Mary F
authors.initials: MF
authors.lastname: Mulcahy
authors.forename: Debiao
authors.initials: D
authors.lastname: Li
authors.forename: Reed A
authors.initials: RA
authors.lastname: Omary
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology / Q000628:therapy; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic; D005240:Feasibility Studies; D006499:Hepatic Artery / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D011817:Rabbits
chemical_list: D010100:Oxygen