Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis.
Inbred mice vary in their susceptibility to develop macroscopic, chemically-induced, pulmonary neoplasias. It is not known, however, whether microscopic lesions appear in resistant strains but do not grow or if no early lesions arise at all. We show herein that resistant C57BL/6J (B6) and intermediately resistant BALB/cByJ (BALB) mice form very few urethane-induced early microadenomas (i.e. adenomas larger than hyperplasic foci, but detectable only by light microscopy). Additionally, while all urethane-induced microadenomas in sensitive A/J mice gave rise to adenomas, most microscopic tumors induced in BALB mice by 2-stage, 3-methylcholanthrene/butylated hydroxytoluene carcinogenesis spontaneously regressed. The formation of microscopic lesions is thus genetically dependent, but whether they continue to grow or regress depends on how they were induced.
O'Donnell
E Paul
EP
Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Box C238, 4200 East Ninth Avenue, Denver, CO 80262, USA.
Zerbe
Laura K
LK
Dwyer-Nield
Lori D
LD
Kisley
Lori R
LR
Malkinson
Alvin M
AM
D000236:Adenoma / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004198:Disease Susceptibility; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D008297:Male; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000633:toxicity*; D014520:Urethane / Q000633:toxicity*
D009153:Mutagens; D002084:Butylated Hydroxytoluene; D014520:Urethane; D008748:Methylcholanthrene