title: Preliminary evidence for a change in spectral sensitivity of the circadian system at night.
abstract: BACKGROUND
  It is well established that the absolute sensitivity of the suprachiasmatic nucleus to photic stimulation received through the retino-hypothalamic tract changes throughout the 24-hour day. It is also believed that a combination of classical photoreceptors (rods and cones) and melanopsin-containing retinal ganglion cells participate in circadian phototransduction, with a spectral sensitivity peaking between 440 and 500 nm. It is still unknown, however, whether the spectral sensitivity of the circadian system also changes throughout the solar day. Reported here is a new study that was designed to determine whether the spectral sensitivity of the circadian retinal phototransduction mechanism, measured through melatonin suppression and iris constriction, varies at night.
  
  
  METHODS
  Human adult males were exposed to a high-pressure mercury lamp [450 lux (170 microW/cm2) at the cornea] and an array of blue light emitting diodes [18 lux (29 microW/cm2) at the cornea] during two nighttime experimental sessions. Both melatonin suppression and iris constriction were measured during and after a one-hour light exposure just after midnight and just before dawn.
  
  
  RESULTS
  An increase in the percentage of melatonin suppression and an increase in pupil constriction for the mercury source relative to the blue light source at night were found, suggesting a temporal change in the contribution of photoreceptor mechanisms leading to melatonin suppression and, possibly, iris constriction by light in humans.
  
  
  CONCLUSIONS
  The preliminary data presented here suggest a change in the spectral sensitivity of circadian phototransduction mechanisms at two different times of the night. These findings are hypothesized to be the result of a change in the sensitivity of the melanopsin-expressing retinal ganglion cells to light during the night.
authors.affiliation: Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180, USA. figuem@rpi.edu
authors.forename: Mariana G
authors.initials: MG
authors.lastname: Figueiro
authors.forename: John D
authors.initials: JD
authors.lastname: Bullough
authors.forename: Robert H
authors.initials: RH
authors.lastname: Parsons
authors.forename: Mark S
authors.initials: MS
authors.lastname: Rea