[Genetic polymorphisms of apoptosis-associated genes FAS and FASL and risk of colorectal cancer].
OBJECTIVE
The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signaling pathway has been shown to participate in tumorigenesis. We previously have shown that the FAS-1377G/A and FASL-844T/C polymorphisms are associated with esophageal cancer. This case-control study was to examine the contribution of the polymorphisms to susceptibility of colorectal cancer.


METHODS
PCR-RFLP method was used to determine the genotypes of FAS-1377G/A and FASL-844T/C in 382 patients with colorectal cancer and 648 controls. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression model.


RESULTS
The subjects with the AA genotype of FAS-1377G/A and CC genotype of FASL-844T/C had an increased risk for colorectal cancer compared with those with the FAS-1377GG genotype (adjusted OR, 1.65; 95% CI, 1.14-2.38) and FASL-844TT genotype (adjusted OR, 1.76; 95% CI, 1.37-2.28). Furthermore, the effect of FAS and FASL polymorphisms on risk of colorectal cancer displayed a significantly gene-gene interaction (likelihood ratio test, P = 0.002).


CONCLUSIONS
These findings suggest that the FAS-1377G/A and FASL-844T/C polymorphisms may be genetic susceptibility factors for colorectal cancer among Chinese population.
Yang
Shen
S
Department of Gastroenterological Surgery, Peking University People's Hospial, Beijing 100044, China.
Miao
Xiao-ping
XP
Zhang
Xue-mei
XM
Sun
Tong
T
Qu
Shi-ning
SN
Xiong
Ping
P
Ye
Ying-jiang
YJ
Guo
Yong-li
YL
Tan
Wen
W
Wang
Shan
S
Lin
Dong-xin
DX
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D053222:Fas Ligand Protein / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D019014:fas Receptor / Q000096:biosynthesis* / Q000235:genetics*
D053222:Fas Ligand Protein; D019014:fas Receptor