Experimental hyperthyroidism-induced oxidative stress and impairment of antioxidant defence system in rat testis.
Short-term hyperthyroidism, induced by daily administration of T3 (20 microg/100g body weight) for one, three, and five days consecutively, modulates oxidative stress and antioxidant defence parameters in mitochondrial and postmitochondrial fractions of testis in adult rats. Alteration in antioxidant defences along with oxidative stress parameters in testis by thyroid hormone was found to be associated with a decline in the number of sperms and disturbances in histoarchitecture of seminiferous tubules in the testes; the results indicated that induced hyperthyroid state altered testicular physiology by influencing antioxidant defence system of testes.
Sahoo
Dipak K
DK
Department of Biotechnology, Utkal University, Bhubaneswar 7510 04, India.
Roy
Anita
A
Bhanja
Shravani
S
Chainy
G B N
GB
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D015153:Blotting, Western; D001835:Body Weight; D002244:Carbon / Q000737:chemistry; D002374:Catalase / Q000737:chemistry; D004195:Disease Models, Animal; D006980:Hyperthyroidism / Q000473:pathology*; D015227:Lipid Peroxidation; D008297:Male; D016877:Oxidants / Q000737:chemistry; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000378:metabolism / Q000473:pathology*; D017392:Thiobarbituric Acid Reactive Substances; D013997:Time Factors; D014018:Tissue Distribution
D000975:Antioxidants; D016877:Oxidants; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D002244:Carbon; D002374:Catalase; D013482:Superoxide Dismutase