[Progress in research of aldose reductase inhibitors in traditional medicinal herbs].
The traditional medicinal herbs are natural product, and have no obviously toxic action and side effect, and their resources are extensive. The adverse effects produced by aldose reductase inhibitors in traditional medicinal herbs are less than those from chemical synthesis and micro-organism, they can effectively prevent and delay diabetic complication, such as diabetic nephropathy, vasculopathy, retinopathy, peripheral neuropathy, and so on. They will have a wonderful respect. Flavonoid compounds and their derivates from traditional medicinal herbs are active inhibitors to aldose reductase, such as quercetin, silymarin, puerarin, baicalim, berberine and so on. In addition, some compound preparations show more strongly activity in inhibiting aldose reductase and degrading sorbitol contents, such as Shendan in traditional medicinal herbs being active inhibitors and Jianyi capsule, Jinmaitong composita, Liuwei Di-huang pill, et al. The progresses definite functions of treating diabetes complications have been reviewed.
Feng
Chang-Gen
CG
Center for Research and Development of New Medicine, Beijing Institute of Technology, Beijing 100081, China. cgfeng@wuma.com.cn
Zhang
Lin-Xia
LX
Liu
Xia
X
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D003928:Diabetic Nephropathies / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000378:metabolism; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011794:Quercetin / Q000302:isolation & purification / Q000494:pharmacology*; D000077385:Silybin; D012838:Silymarin / Q000302:isolation & purification / Q000494:pharmacology
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D007529:Isoflavones; D012838:Silymarin; C476907:liu-wei-di-huang wan; D000077385:Silybin; D011794:Quercetin; D000449:Aldehyde Reductase; C033607:puerarin