Mustard: a potential agent of chemical warfare and terrorism.
As one of the most important vesicant agents, the destructive properties of mustards on the skin, eyes and respiratory system, combined with a lack of antidote, makes them effective weapons. Such weapons are inexpensive, easily obtainable and frequently stockpiled. Sulphur mustard (mustard gas) has been used as a chemical warfare agent in at least 10 conflicts. In this article, the use of mustard as a potential agent of chemical warfare and terrorism is outlined. The dose-dependent effects of acute sulphur mustard exposure on the skin, eyes, and respiratory system are described, as well as the possible extents of injuries, the mechanisms of action and the long-term complications. Prevention and management of mustard exposure are briefly discussed. The need for awareness and preparedness in the dermatological community regarding mustard exposure is emphasized.
Saladi
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RN
Department of Dermatology, Mount Sinai Medical Center, New York, NY 10029-6574, USA. rao.saladi@mssm.edu
Smith
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E
Persaud
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AN
D000328:Adult; D051337:Chemical Terrorism / Q000517:prevention & control; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002648:Child; D003879:Dermatologic Agents / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009150:Mustard Compounds / Q000008:administration & dosage / Q000633:toxicity*; D009151:Mustard Gas / Q000008:administration & dosage / Q000633:toxicity; D009588:Nitrogen Mustard Compounds / Q000633:toxicity; D012867:Skin / Q000187:drug effects; D012871:Skin Diseases / Q000517:prevention & control; D013997:Time Factors
D002619:Chemical Warfare Agents; D003879:Dermatologic Agents; D009150:Mustard Compounds; D009588:Nitrogen Mustard Compounds; D009151:Mustard Gas