Hyperbaric oxygen should not be used in the management of hemorrhagic cystitis in patients with Fanconi anemia.
Hemorrhagic cystitis (HC) is a common complication after stem cell transplantation (SCT) that occurs more frequently in patients with Fanconi anemia (FA) because of hypersensitivity of their cells to the agents used in the preparation for SCT (chemo and radiation). Many HC cases respond to therapy with hyperhydration and maintenance of adequate platelet counts, but refractory cases may require additional measures such as the use of prostaglandins, alum, or hyperbaric oxygen (HBO). We report here an unusual complication to HBO therapy in a FA patient consisting of generalized edema mimicking capillary leak syndrome but with no pulmonary edema or ascites.
Al-Seraihi
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Section of Stem Cell Transplant, Department of Pediatric Hematology/Oncology, KFSHRC, Riyadh, Saudi Arabia. aseraihy@kfshrc.edu.sa
Ayas
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D019559:Capillary Leak Syndrome / Q000209:etiology; D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D003556:Cystitis / Q000150:complications* / Q000628:therapy; D004487:Edema / Q000209:etiology*; D005199:Fanconi Anemia / Q000150:complications* / Q000628:therapy; D006470:Hemorrhage / Q000150:complications* / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D014184:Transplantation, Homologous