[Clinical evaluation of intrapleural or peritoneal repetitive administration of Lentinan and OK-432 for malignant effusion].
LTN and OK-432 combined therapy is effective for controlling Th1/Th2 balance. We tried a repetitive administration of LTN and OK-432 in the pleural or peritoneal cavity for patients with malignant effusion. Of all 11 lesions of the 10 cases, 7 revealed complete remission and 1 revealed partial response. The level of IL-12 (p70) and IFN-gamma in ascites of two gastric cancer patients after the second administration of LTN and OK-432 was much higher than those after the first administration, whereas the level of IL-10 was not suppressed strongly. In 8 lesions that we could confirm complete remission or partial response, 7 lesions were improved after two or three administrations of LTN and OK-432. In conclusion, a repetitive intracavital administration of LTN and OK-432 is effective for malignant effusion.
Kawaoka
Toru
T
Dept of Surgery I, Yamaguchi University School of Medicine.
Yoshino
Shigefumi
S
Kondo
Hiroshi
H
Yamamoto
Koutaro
K
Hazama
Shoichi
S
Oka
Masaaki
M
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001202:Ascitic Fluid / Q000737:chemistry / Q000187:drug effects; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis; D016753:Interleukin-10 / Q000032:analysis; D018664:Interleukin-12 / Q000032:analysis; D007912:Lentinan / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010529:Peritoneal Cavity; D010844:Picibanil / Q000008:administration & dosage*; D035422:Pleural Cavity; D016066:Pleural Effusion, Malignant / Q000188:drug therapy*
D000970:Antineoplastic Agents; D016753:Interleukin-10; D018664:Interleukin-12; D007912:Lentinan; D010844:Picibanil; D007371:Interferon-gamma