title: Functional evaluation of regenerated and misrouted low threshold mechanoreceptors and polymodal nociceptors in the skin of rat hindfeet after crush lesions to the sciatic nerve.
abstract: Tracer studies on motor axons after nerve crush injuries have indicated that misrouting may occur even when the endoneurium is intact. Misrouting of regenerated polymodal nociceptive C-fibres and low threshold mechanoreceptive axons have been studied functionally in 50 rats three months after unilateral crush lesions to the sciatic nerve. Two weeks before evaluation the tibial fascicle (or the peroneal fascicle) above the lesion was cut and tied off. In this way only functional regeneration of misrouted axons was tested. Misrouted low threshold mechanoreceptive axons and polymodal nociceptor C-fibres were found after regeneration in both glabrous and hairy skin. We conclude that functional misdirection of both myelinated and unmyelinated sensory axons innervating either glabrous or hairy skin can occur after a crush lesion to a peripheral nerve in rats.
authors.affiliation: Department of Plastic Surgery, Hand Surgery & Burns, University Hospital, Linköping, Sweden. Thomas.Hansson@ibk.liu.se
authors.forename: Thomas
authors.initials: T
authors.lastname: Hansson
authors.forename: Bo
authors.initials: B
authors.lastname: Povlsen
mesh_terms: D000818:Animals; D005260:Female; D006614:Hindlimb / Q000294:innervation; D008465:Mechanoreceptors / Q000503:physiopathology*; D023421:Models, Animal; D009416:Nerve Regeneration / Q000502:physiology*; D009619:Nociceptors / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries* / Q000503:physiopathology*; D012867:Skin / Q000294:innervation; D014949:Wounds, Nonpenetrating / Q000503:physiopathology