title: Identification of an OprD homologue in Acinetobacter baumannii.
abstract: With the increased number of resistant Acinetobacter baumannii strains, it is urgently required to decipher the molecular bases of outer membrane permeability. The analyses of the outer membrane from different A. baumannii strains indicated a modification in the expression of two proteins of 29 and 43 kDa, respectively. By electrophoresis and MALDI-MS analyses, the 43 kDa OMP was identified as a protein belonging to the OprD family, a basic amino acid and imipenem porin.
authors.affiliation: EA2197, IFR48, Faculté de Médecine, Université de la Méditerranée, Marseille Cedex 05, France.
authors.forename: Myrielle
authors.initials: M
authors.lastname: Dupont
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Pagès
authors.forename: Daniel
authors.initials: D
authors.lastname: Lafitte
authors.forename: Axel
authors.initials: A
authors.lastname: Siroy
authors.forename: Claude
authors.initials: C
authors.lastname: Bollet
mesh_terms: D040981:Acinetobacter baumannii / Q000378:metabolism*; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry; D024881:Drug Resistance, Bacterial; D004591:Electrophoresis, Polyacrylamide Gel; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D018272:Porins / Q000737:chemistry*; D020543:Proteome; D040901:Proteomics / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D010455:Peptides; D018272:Porins; D020543:Proteome; C077157:OprD protein, Pseudomonas aeruginosa