title: The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure.
abstract: We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.
authors.affiliation: Département de Biologie, Université de Sherbrooke, Quebec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Douville
authors.forename: Jocelyn
authors.initials: J
authors.lastname: David
authors.forename: Karine M
authors.initials: KM
authors.lastname: Lemieux
authors.forename: Luc
authors.initials: L
authors.lastname: Gaudreau
authors.forename: Dindial
authors.initials: D
authors.lastname: Ramotar
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D015152:Blotting, Northern; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D009154:Mutation; D019696:Peptidylprolyl Isomerase; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D020123:Sirolimus / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; C502440:PPH3 protein, S cerevisiae; D010749:Phosphoprotein Phosphatases; D019696:Peptidylprolyl Isomerase; C490203:RRD1 protein, S cerevisiae; D020123:Sirolimus