An annulation toward fused bicyclolactones.
The combination of Lewis and Bronsted acids catalyzed the addition of beta-ketoesters to cyclic diene. Lactonization occurs in situ to afford fused bicyclic lactones directly. The catalysis provides an expedient route to bicylic lactones via a zip-process.
Nguyen
Rene-Viet
RV
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
Li
Chao-Jun
CJ