Parvovirus B19: a new emerging pathogenic agent of inflammatory cardiomyopathy.
The human parvovirus B19 (PVB19), an erythrovirus causing diverse clinical manifestations ranging from asymptomatic or mild to more severe outcomes such as hydrops fetalis, is the only currently known human pathogenic parvovirus. Recently, PVB19 has been identified as a causative agent of pediatric and adult inflammatory cardiac diseases. The first hints for a possible etiopathogenetic role of the PVB19 infection and the development of cardiac dysfunction were demonstrated by molecular biology methods such as in situ hybridization (ISH) and polymerase chain reaction (PCR). In this regard, PVB19-associated inflammatory cardiomyopathy is characterized by infection of endothelial cells of small intracardiac arterioles and venules, which may be associated with endothelial dysfunction, impairment of myocardial microcirculation, and penetration of inflammatory cells in the myocardium.
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Department of Molecular Pathology, Institute of Pathology, University Hospital of Tübingen, Germany. thomas.bock@med.uni-tuebingen.de
D009202:Cardiomyopathies / Q000209:etiology / Q000276:immunology / Q000821:virology; D004699:Endocardium / Q000473:pathology / Q000821:virology; D016679:Genome, Viral; D006801:Humans; D025202:Molecular Diagnostic Techniques; D010322:Parvoviridae Infections / Q000150:complications / Q000276:immunology; D016732:Parvovirus B19, Human / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000502:physiology