title: Increase in slow afterhyperpolarization led to learning delay in DBA mice.
abstract: We showed that differences in learning capacity between DBA and C57Bl/6 mice correlates with differences in slow afterhyperpolarization amplitude in hippocampal CA1 pyramid neurons. In DBA mice learning capacity is lower, but the amplitude of slow afterhyperpolarizations higher than in C57Bl/6 mice.
authors.affiliation: Memorypharm Pharmacological Company, New Jersey, USA.
authors.forename: G Y
authors.initials: GY
authors.lastname: Oksman
authors.forename: K
authors.initials: K
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Rose
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitsky
authors.forename: N B
authors.initials: NB
authors.lastname: Fedorov
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004924:Escape Reaction; D006624:Hippocampus / Q000502:physiology; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008564:Membrane Potentials; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009435:Synaptic Transmission