Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin.
Nuclear targeting of beta-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes beta-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of beta-catenin. We speculate that cells may use multiple export mechanisms to inhibit beta-catenin signaling in different ways.
Thorne
Meghan E
ME
Department of Medicine, Northwestern University, Chicago, IL 60637, USA.
Gottardi
Cara J
CJ
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004331:Drosophila melanogaster; D004625:Embryo, Nonmammalian / Q000196:embryology / Q000378:metabolism; D028884:Karyopherins / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*; D029543:Nucleocytoplasmic Transport Proteins / Q000502:physiology*; D010766:Phosphorylation; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000502:physiology*; D014982:Xenopus laevis; D051176:beta Catenin / Q000378:metabolism*; D000097606:Exportin 1 Protein
D028884:Karyopherins; D009687:Nuclear Proteins; D029543:Nucleocytoplasmic Transport Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D051153:Wnt Proteins; D051176:beta Catenin; D000097606:Exportin 1 Protein; C112820:RANBP3 protein, human