title: Primary progressive aphasia as the initial manifestation of corticobasal degeneration. A "three in one " syndrome?
abstract: In 1994, the term "Pick complex" was proposed to indicate significant clinical and pathological overlapping between primary progressive aphasia, frontal lobe dementia and corticobasal degeneration. We report the case of a 60-year-old man, who initially presented progressive non-fluent aphasia with orofacial apraxia, and subsequently, over a period of 3 years, developed mutism, pathological laughter, extrapyramidal rigidity, dystonia, alien hand syndrome and bulbar signs. An extensive haematological, immunological and biochemical work up was normal. The results of neuroimaging studies and neuropsychological tests, along with the clinical evolution, finally led us to the ?three in one? diagnosis, supporting the concept of Pick complex.
authors.affiliation: Department of Neurology, Aristotle University School of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Panos
authors.initials: P
authors.lastname: Ioannides
authors.forename: Dimitris
authors.initials: D
authors.lastname: Karacostas
authors.forename: Maria
authors.initials: M
authors.lastname: Hatzipantazi
authors.forename: Milonas
authors.initials: M
authors.lastname: Ioannis
mesh_terms: D018888:Aphasia, Primary Progressive / Q000175:diagnosis* / Q000209:etiology; D001480:Basal Ganglia Diseases / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications / Q000175:diagnosis*; D020774:Pick Disease of the Brain / Q000150:complications / Q000175:diagnosis*