title: [The relationship between ApoE gene polymorphism and lipid parameters].
abstract: OBJECTIVE
  To investigate the relationship between apolipoprotein E (ApoE) gene polymorphism and serum lipid profile.
  
  
  METHODS
  Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) was used to determine ApoE genotype on 1452 subjects including 1101 cases with cardio cerebrovascular disease including 379 cases with cerebral infarction, 313 cases with cerebral hemorrhage, 257 cases with coronary heart disease, and 152 cases with other types and on 351 healthy controls.
  
  
  RESULTS
  After adjusting for age, sex and BMI, the subjects with ApoE4 carriers had significantly higher levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and ApoB than those with ApoE2 carriers and ApoE3/3 (P < 0.05), and higher level of triglyceride(TG) than those with ApoE3/3 (P < 0.05), while the subjects with ApoE2 carriers had significantly higher levels of high density lipoprotein-cholesterol (HDL-C) than those with ApoE4 (P < 0.05). The effects of ApoE polymorphism exhibited similarity in different sex and age of subjects. Linear regression analysis showed that unlike ApoE3/3, the HDL-C level in ApoE2 carriers tend upward with age (beta = 0.178, P = 0.015), significantly higher than ApoE4 carriers and ApoE3/3 in the cohort of 65-74 years (P < 0.05). The level of TC and TG in ApoE4 carriers had a tendency of downward with age (p = -0.179, P = 0.009; beta = -0.147, P = 0.032).
  
  
  CONCLUSIONS
  ApoE gene polymorphism affected profile of blood lipids and the effects were found in different sex and age. The degrees of effects related to ApoE2 carriers and ApoE4 carriers to blood lipid level seemed to be related to age.
authors.affiliation: Department of Neurology, Xiangya Second Hospital of Central South University, Changsha 410011, China.
authors.forename: Zhi-jie
authors.initials: ZJ
authors.lastname: Xiao
authors.forename: Shui-ping
authors.initials: SP
authors.lastname: Zhao
authors.forename: Sai
authors.initials: S
authors.lastname: Nie
authors.forename: Li-min
authors.initials: LM
authors.lastname: Tan
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D055815:Young Adult
chemical_list: D001057:Apolipoproteins E; D008055:Lipids