title: Comparison of verapamil and cimetidine for their effects on volume and acidity of Carbachol induced gastric secretion in fasting rabbits.
abstract: BACKGROUND
  Peptic ulcer is a common ailment for which over production of gastric acid is the main cause. This study was undertaken to find out the effects of Calcium channel blocker Verapamil and Cimetidine on volume and acidity of Carbacol induced gastric section, free and total acidity of carbachol induced gastric secretion and their effects were also compared.
  
  
  METHODS
  Thirty rabbits of local breed weighing 1-1.5kg were used. The animals were kept on fasting for 48 hours after which the pylorus of each was ligated. Verapamil 10mg/kg, Cimetidine 2.5 mg/kg and Carbachol 600 microg/kg body weight were administered intrapertoneally in pylorus ligated rabbits.
  
  
  RESULTS
  It was found that Verapamil reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Cimetidine also had the same effects. when the difference of means values brought about by verapamil were compared with those of Cimetidine, all these differences were found statistically non significant, indicating that Verapamil has similar effect as that of Cimetidine on all parameters included in study.
  
  
  CONCLUSIONS
  Verapamil has significant effect on volume and acidity of carbachol induced gastric secretion.
authors.affiliation: Department of Pharmacology, Saidu Medical College, Swat, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Jan
authors.forename: Shaukat Ali
authors.initials: SA
authors.lastname: Orakzai
authors.forename: Shafique
authors.initials: S
authors.lastname: Tariq
authors.forename: Muhammad
authors.initials: M
authors.lastname: Javid
authors.forename: Shafiq
authors.initials: S
authors.lastname: Ahmad
authors.forename: Muhammad
authors.initials: M
authors.lastname: Haroon
authors.forename: Muhammad
authors.initials: M
authors.lastname: Qamar
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002217:Carbachol; D002927:Cimetidine / Q000494:pharmacology*; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D002217:Carbachol; D014700:Verapamil