The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms.
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
Saxena
Ajay K
AK
Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Twinbrook 2, 12441 Parklawn Drive, Rockville, Maryland 20852, USA. asaxena@mail.jnu.ac.in
Singh
Kavita
K
Su
Hua-Poo
HP
Klein
Michael M
MM
Stowers
Anthony W
AW
Saul
Allan J
AJ
Long
Carole A
CA
Garboczi
David N
DN
D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry* / Q000378:metabolism*; D000954:Antigens, Surface / Q000737:chemistry* / Q000378:metabolism*; D009033:Culicidae / Q000469:parasitology*; D017780:Malaria Vaccines / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D010966:Plasmodium vivax / Q000737:chemistry* / Q000254:growth & development* / Q000378:metabolism; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D017780:Malaria Vaccines; C121473:Pvs25 protein, P vivax; C121474:Pvs28 protein, P vivax