title: Obstructive sleep apnea syndrome: a potential cause of lower airway obstruction in cystic fibrosis.
abstract: A six-year-old healthy female with cystic fibrosis (CF) and pancreatic sufficiency presented with cough, weight loss, and lung function decline. Further history suggested obstructive sleep apnea, and nocturnal polysomnography (NPSG) confirmed this. Adenotonsillectomy resulted in resolution of clinical symptoms with return of normal lung function. This case establishes that obstructive sleep apnea syndrome (OSAS) may be a potential cause of lower airway inflammation and resulting weight loss in the young CF population.
authors.affiliation: Departments of Pediatrics and Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA. d.hayes@hosp.wisc.edu
authors.forename: D
authors.initials: D
authors.lastname: Hayes
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D001999:Bronchoscopy / Q000379:methods; D002245:Carbon Dioxide / Q000378:metabolism; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005336:Fiber Optic Technology / Q000295:instrumentation; D006801:Humans; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000378:metabolism; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D012895:Sleep, REM / Q000502:physiology
chemical_list: D002245:Carbon Dioxide