Bilateral diffuse uveal melanocytic proliferation in a patient with cancer-associated retinopathy.
OBJECTIVE
To describe a patient with bilateral diffuse uveal melanocytic proliferation (BDUMP) and cancer-associated retinopathy (CAR).


METHODS
Interventional case report.


METHODS
A 66-year-old woman developed progressive vision loss 4 months after total hysterectomy. Ophthalmologic examination, Western blot test of sera and aqueous humor, and immunohistochemistry of carcinoma cells were performed.


RESULTS
Testing revealed BDUMP and severe retinal dysfunction. Autoantibodies against recoverin and heat shock cognate protein 70 (hsc 70) were detected in serum. Cytoplasmic immunoreactivity for recoverin and hsc 70 was observed in endometrioid carcinoma cells.


CONCLUSIONS
Simultaneous cases of BDUMP and CAR are rare. Aberrantly expressed recoverin and hsc 70 triggered serum autoantibody production, which caused photoreceptor degeneration.
Saito
Wataru
W
Department of Ophthalmology and Visual Sciences, Hokkaido Graduate School of Medicine, Sapporo, Japan. wsaito@med.hokudai.ac.jp
Kase
Satoru
S
Yoshida
Kazuhiko
K
Ohguro
Hiroshi
H
Yokoi
Masahiko
M
Iwaki
Hiroyuki
H
Ohno
Shigeaki
S
D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D015153:Blotting, Western; D049109:Cell Proliferation; D004596:Electroretinography; D016889:Endometrial Neoplasms / Q000601:surgery; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D013509:Gynecologic Surgical Procedures; D050883:HSC70 Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007208:Indocyanine Green; D008544:Melanocytes / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D051603:Recoverin / Q000276:immunology; D012164:Retinal Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D014603:Uveal Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D005938:Glucocorticoids; D050883:HSC70 Heat-Shock Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D011239:Prednisolone; D007208:Indocyanine Green