Effects of aloe, aloesin, or propolis on the pharmacokinetics of benzo[a]pyrene and 3-OH-benzo[a]pyrene in rats.
This study was conducted to examine the effects of aloe and aloesin on the weight gain and blood chemistry as well as the pharmacokinetics of benzo[a]pyrene (BaP) and 3-OH-BaP in rats. The rats treated with multiple doses of aloe and aloesin (100 mg/kg every 12 h for 14-19 d) did not show any significant changes in the weight gain and blood biochemical parameters. In addition, the effects of oral treatment with aloe, aloesin, and propolis on the absorption and pharmacokinetics of benzo[a]pyrene (BaP) and its metabolite, 3-OH-BaP, were studied in rats. The treatment with a single oral dose (200 mg/kg) of aloe, aloesin, and propolis did not alter the concentration-time profiles of BaP and 3-OH-BaP after iv and oral administration of BaP. At higher oral doses (500 mg/kg), the biliary excretion of BaP and the urinary excretion of 3-OH-BaP were significantly increased, but the urinary excretion of BaP and the fecal excretion of 3-OH-BaP remained unaltered. Whether high doses of aloe increase the overall elimination of BaP deserves further investigation.
Cao
Dianxiu
D
College of Pharmacy, Sungkyunkwan University, Changan-gu, Suwon, Kyonggi-do, Korea.
Yoon
Chi Ho
CH
Shin
Beom Soo
BS
Kim
Chul Hwan
CH
Park
Eun Seok
ES
Yoo
Sun Dong
SD
D000504:Aloe; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001580:Benzopyrenes / Q000378:metabolism / Q000493:pharmacokinetics*; D001646:Bile / Q000737:chemistry; D001835:Body Weight / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D005960:Glucosides / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D011429:Propolis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014556:Urine / Q000737:chemistry
D001580:Benzopyrenes; D002867:Chromones; D005960:Glucosides; D010936:Plant Extracts; D001564:Benzo(a)pyrene; C021338:3-hydroxybenzo(a)pyrene; D011429:Propolis; C069868:aloesin