Genes for normal sleep and sleep disorders.
Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocretin/orexin gene have been found as the cause of a few sleep disorders but the possibility that other gene defects may contribute to the pathophysiology of major sleep disorders is worth in-depth investigations. However, single gene disorders are rare and most common disorders are complex in terms of their genetic susceptibility, environmental effects, gene-gene, and gene-environment interactions. We review here the current progress in the genetics of normal and pathological sleep.
Tafti
Mehdi
M
Center for Integrative Genomics, University of Lausanne, 1015 Lausanne-Dorigny, Switzerland. Mehdi.Tafti@unil.ch
Maret
Stéphanie
S
Dauvilliers
Yves
Y
D002940:Circadian Rhythm / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D000068797:Orexins; D056950:Period Circadian Proteins; D017354:Point Mutation; D011498:Protein Precursors / Q000235:genetics*; D012890:Sleep / Q000235:genetics*; D012893:Sleep Wake Disorders / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D009687:Nuclear Proteins; D000068797:Orexins; C421902:PER2 protein, human; D056950:Period Circadian Proteins; D011498:Protein Precursors; D014157:Transcription Factors; D004247:DNA