[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].
A high performance liquid chromatography method was established for determination of antidangdruff agent salicylic acid,zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo on a C18 column using acetonitrile-metholaqueous solution (10 mmol/L KH2 PO4 and 5 mmol/L EDTANa2, pH is adjusted to 4.0 with H3 PO4) (50:10:40) as mobile phase at a flow rate of 1.0 ml/min, with the column temperature 25 degrees C and detection wave 230nm. The precision was less than 3.8% and recovery varied from 92.7% to 104.9%. The experimental results showed that the method was simple, precise and accurate.
Yang
Yan-Wei
YW
Institute for Environmental Hygiene and Health Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Zhu
Ying
Y
Su
Xiao-Qing
XQ
D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004983:Ethanolamines / Q000032:analysis*; D006203:Hair Preparations / Q000032:analysis / Q000737:chemistry*; D007093:Imidazoles / Q000032:analysis*; D007654:Ketoconazole / Q000032:analysis; D009942:Organometallic Compounds / Q000032:analysis*; D011725:Pyridines / Q000032:analysis*; D011728:Pyridones / Q000032:analysis*; D020156:Salicylic Acid / Q000032:analysis*
D004338:Drug Combinations; D004983:Ethanolamines; D006203:Hair Preparations; D007093:Imidazoles; D009942:Organometallic Compounds; D011725:Pyridines; D011728:Pyridones; C108286:climbazole; C052599:piroctone olamine; D020156:Salicylic Acid; D007654:Ketoconazole; C010423:pyrithione zinc