Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex.
The present study examined the effect of zotepine, an atypical antipsychotic, on the in vivo release of monoamines in the prefrontal cortex of rats using microdialysis. Local perfusion of zotepine at 10 microM increased extracellular levels of serotonin (5-HT), as well as dopamine and noradrenaline, in the prefrontal cortex. However, systemic administration of zotepine did not affect 5-HT release, although it increased the dopamine and noradrenaline release. These results suggest that the prefrontal 5-HT system does not contribute to the antidepressant effect of zotepine. The difference in the effect of zotepine between local and systemic treatment is discussed.
Nakamura
Shigeo
S
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Ago
Yukio
Y
Itoh
Soichi
S
Koyama
Yutaka
Y
Baba
Akemichi
A
Matsuda
Toshio
T
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D003988:Dibenzothiepins / Q000008:administration & dosage*; D004298:Dopamine / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D017551:Microdialysis; D009638:Norepinephrine / Q000378:metabolism*; D010477:Perfusion; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D012701:Serotonin; C022172:zotepine; D004298:Dopamine; D009638:Norepinephrine