title: [Effect of Zhongfengkang on the content of insulin-like growth factor-1 in brain of the rats with focal cerebral ischemia].
abstract: OBJECTIVE
  To observe the effect of Zhongfengkang on the content of insulin-like growth factor-1 (IGF-1) in brain of focal cerebral ischemia rats.
  
  
  METHODS
  The model of focal cerebral ischemia was made by thread-blocking method. In comparison with the curative effect of buchangnaoxintong, the action of Zhongfengkang on infarct volume and the content of IGF-1 in brain of focal cerebral ischemia rats were observed in 6, 12, 24 h and 48 h after cerebral ischemia.
  
  
  RESULTS
  As compared with sham operation group, the content of IGF-1 in brain of model group was gradually increased from 6th hour after cerebral ischemia, reaching to the maximal level at 24th hour after the onset of cerebral ischemia (P < 0.01). In comparison with the values in model group at the corresponding time points, the content of IGF-1 in brain of each treatment groups was increased in different extent with a maximal enhancement in the group treated by the high dose of Zhongfengkang (P < 0. 05 or P < 0.01); while the infarct volume of each treatment groups were decreased significantly (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  Zhongfengkang could effectively protect the cerebral tissue from injury of focal cerebral ischemia in the rats through increasing the cerebral content of IGF-1 and reducing infarct volume.
authors.affiliation: College of Traditional Chinese Medicine, Hebei Medical University, Shijiazhuang 050091, China. yangmx427@163.com
authors.forename: Mu-Xiang
authors.initials: MX
authors.lastname: Yang
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Yu
authors.forename: Feng-Zhe
authors.initials: FZ
authors.lastname: Su
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007334:Insulin-Like Growth Factor I