title: Prolonged ischemic conduction failure after reperfusion in diabetic nerve.
abstract: Diabetic nerve exhibits morphological vulnerability to ischemia and reperfusion, in contrast to its physiological resistance to ischemic conduction failure (RICF). To examine the sequence of ischemic conduction failure after reperfusion in diabetic nerve, we measured sciatic-tibial nerve conduction before and during 30-180 min of ischemia and after reperfusion for up to 1 week in streptozocin (STZ)-induced diabetic rats. RICF in diabetic rats was confirmed during ischemia. After reperfusion, control nerves showed an immediate recovery in amplitude of compound muscle action potential (CMAP) following ischemia for 120 min or less, and delayed recovery after 150 min of ischemia. In contrast, recovery in diabetic nerves was delayed even after 1 h of ischemia. Ischemia for 75 min in diabetic nerve resulted in either delayed or no recovery of the CMAP upon reperfusion. Following ischemia for 90 or 120 min, axonal degeneration was observed in diabetic nerve. Thus, severe ischemia for 60 or 75 min causes prolonged ischemic conduction failure in diabetic nerve, compared with 150 min in control nerve. In conclusion, diabetic nerve shows delayed recovery of ischemic conduction failure after brief ischemia, compared to controls, suggesting that patients with diabetic neuropathy have a worse prognosis when faced with nerve ischemia.
authors.affiliation: Department of Neurology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan. masababa@cc.hirosaki-u.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Baba
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nukada
authors.forename: Denise
authors.initials: D
authors.lastname: McMorran
authors.forename: Kazunori
authors.initials: K
authors.lastname: Takahashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Wada
authors.forename: Soroku
authors.initials: S
authors.lastname: Yagihashi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000503:physiopathology*; D004558:Electric Stimulation; D004594:Electrophysiology; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*; D012584:Sciatic Nerve / Q000473:pathology; D013979:Tibial Nerve / Q000473:pathology
chemical_list: D001786:Blood Glucose