A new mitochondrial RNA deletion fragment accelerated by oxidative stress in rat L6 cells.
RNA deletions may be easier to detect and more extensive than DNA deletions. Two large deletion fragments (1120 and 7811 bp) of mitochondrial RNA were observed in rat L6 muscle cells. At the site of the 1120 bp deletion, the remaining RNA fragment was re-linked by a short additional section (GGTATGAAGCT). These kinds of deletions were accelerated by oxidative stress and were not observed in mitochondrial DNA.
Qiu
Xiao-Zhong
XZ
Department of Anatomy, Southern Medical University, Guangzhou, China.
Yu
Lei
L
Zhang
Li-Sheng
LS
Qin
Jian-Qiang
JQ
Liao
Hua
H
Yang
Jun
J
Ouyang
Jun
J
D000818:Animals; D002460:Cell Line; D004272:DNA, Mitochondrial / Q000235:genetics; D018384:Oxidative Stress; D012313:RNA / Q000235:genetics*; D000077278:RNA, Mitochondrial; D051381:Rats; D017384:Sequence Deletion
D004272:DNA, Mitochondrial; D000077278:RNA, Mitochondrial; D012313:RNA