title: Soy isoflavone aglycone modulates a hematopoietic response in combination with soluble beta-glucan: SCG.
abstract: Soy isoflavone aglycones (IFAs) have a wide range of biological actions that suggest they may be of use in cancer prevention. On the other hand, a branched beta-glucan from Sparassis crispa (SCG) is a major 6-branched 1,3-beta-D-glucan in an edible/medicinal mushroom: Sparassis crispa showing antitumor activity. We have previously reported that both oral and intraperitoneal administration of SCG enhanced the hematopoietic response in cyclophosphamide (CY)-induced leukopenic mice. In this study, we investigated the hematopoietic response due to IFA in combination with SCG in CY-induced leukopenic mice. The oral administration of IFA in combination with SCG synergistically enhanced the number of white blood cells, and increased spleen weight. Analyzing the leukocyte population by flow cytometry, the combination of IFA and SCG increased the number of monocytes and granulocytes in the spleen. Taken together, the combination of IFA and SCG synergistically provides the hematopoietic responses that are enhanced over IFA or SCG alone.
authors.affiliation: Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy & Life Science, Hachioji, Japan.
authors.forename: Toshie
authors.initials: T
authors.lastname: Harada
authors.forename: Susumu
authors.initials: S
authors.lastname: Masuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Arii
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Adachi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nakajima
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yadomae
authors.forename: Naohito
authors.initials: N
authors.lastname: Ohno
mesh_terms: D000284:Administration, Oral; D000363:Agaricales; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005434:Flow Cytometry; D006410:Hematopoiesis / Q000187:drug effects*; D006413:Hematopoietic System / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007529:Isoflavones / Q000494:pharmacology* / Q000627:therapeutic use; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts; D012995:Solubility; D030262:Soybean Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D013025:Glycine max; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D047071:beta-Glucans / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007529:Isoflavones; D010936:Plant Extracts; D030262:Soybean Proteins; D047071:beta-Glucans; C508230:soy isoflavone aglycone