title: Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians.
abstract: BACKGROUND
  The recessive disorder trimethylaminuria is caused by defects in the FMO3 gene, and may be associated with hypertension. We investigated whether common polymorphisms of the FMO3 gene confer an increased risk for elevated blood pressure and/or essential hypertension.
  
  
  METHODS
  FMO3 genotypes (E158K, V257M, E308G) were determined in 387 healthy subjects with ambulatory systolic and diastolic blood pressure measurements, and in a cardiovascular disease population of 1649 individuals, 691(41.9%) of whom had a history of hypertension requiring drug treatment. Haplotypes were determined and their distribution noted.
  
  
  RESULTS
  There was no statistically significant association found between any of the 4 common haplotypes and daytime systolic blood pressure in the healthy population (p = 0.65). Neither was a statistically significant association found between the 4 common haplotypes and hypertension status among the cardiovascular disease patients (p = 0.80).
  
  
  CONCLUSIONS
  These results suggest that the variants in the FMO3 gene do not predispose to essential hypertension in this population.
authors.affiliation: Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland. cdolan@rcsi.ie
authors.forename: Ciara
authors.initials: C
authors.lastname: Dolan
authors.forename: Denis C
authors.initials: DC
authors.lastname: Shields
authors.forename: Alice
authors.initials: A
authors.lastname: Stanton
authors.forename: Eoin
authors.initials: E
authors.lastname: O'Brien
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Lambert
authors.forename: John K
authors.initials: JK
authors.lastname: O'Brien
authors.forename: Eileen P
authors.initials: EP
authors.lastname: Treacy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008661:Metabolism, Inborn Errors / Q000235:genetics; D008744:Methylamines / Q000378:metabolism; D008875:Middle Aged; D020125:Mutation, Missense; D010105:Oxygenases / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D008744:Methylamines; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); C023336:trimethylamine