title: Androstenediol analogs as ER-beta-selective SERMs.
abstract: A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.
authors.affiliation: Merck Research Laboratories, PO Box 2000, Rahway NJ 07065, USA. tim_blizzard@merck.com
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Blizzard
authors.forename: Candido
authors.initials: C
authors.lastname: Gude
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Morgan
authors.forename: Wanda
authors.initials: W
authors.lastname: Chan
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Birzin
authors.forename: Marina
authors.initials: M
authors.lastname: Mojena
authors.forename: Consuelo
authors.initials: C
authors.lastname: Tudela
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Kristin
authors.initials: K
authors.lastname: Knecht
authors.forename: Qin
authors.initials: Q
authors.lastname: Su
authors.forename: Bryan
authors.initials: B
authors.lastname: Kraker
authors.forename: Ralph T
authors.initials: RT
authors.lastname: Mosley
authors.forename: Mark A
authors.initials: MA
authors.lastname: Holmes
authors.forename: Nandini
authors.initials: N
authors.lastname: Sharma
authors.forename: Paula M D
authors.initials: PM
authors.lastname: Fitzgerald
authors.forename: Susan P
authors.initials: SP
authors.lastname: Rohrer
authors.forename: Milton L
authors.initials: ML
authors.lastname: Hammond
mesh_terms: D015114:Androstenediol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D047629:Estrogen Receptor beta / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D020845:Selective Estrogen Receptor Modulators / Q000138:chemical synthesis / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D047629:Estrogen Receptor beta; D008024:Ligands; D020845:Selective Estrogen Receptor Modulators; D015114:Androstenediol