The relationship between histopathological features of progressive supranuclear palsy and disease duration.
Progressive supranuclear palsy (PSP) is a distinct clinicopathological entity characterized by neurofibrillary tangles, tufted astrocytes, threads and oligodendroglial coiled bodies. These four lesions are distributed in varying densities throughout subcortical and brainstem structures. There is no data regarding the relationship of disease duration to lesion burden severity in PSP. We report the results of analysis of semiquantitative data collected as part of the diagnostic evaluation on 97 cases of 'pure' PSP, submitted to the Society of PSP Brain Bank. Surprisingly, the data suggests that in PSP as duration of illness increases there is a decrease in oligodendroglial tau burden.
Josephs
Keith A
KA
Department of Neurology, Mayo Clinic Rochester, MN, USA.
Mandrekar
Jayawant N
JN
Dickson
Dennis W
DW
D000368:Aged; D001253:Astrocytes / Q000473:pathology; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D020541:Coiled Bodies / Q000473:pathology; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology; D009836:Oligodendroglia / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D016875:tau Proteins / Q000378:metabolism
D016875:tau Proteins