title: [Autonomic profile of patients with migraine].
abstract: OBJECTIVE
  Dysfunction of autonomic nervous system (ANS) is implicated in the genesis and persistence of migraine. The objective of this study was to compare autonomic nervous system (ANS) profile of migraineurs during headache-free periods to a group of normal subjects based on cardio-vascular reactivity.
  
  
  METHODS
  Patients with migraine according to the criteria of IHS 2004 were selected for the study. After a 30 min resting blood pressure (BP), the following standard tests were performed: deep-breathing (DB), hand grip (HG) of 15 s and 3 min, valsalva maneuver, echo stress, (ES) and tilt test (TT). Results were compared to 44 normal subjects, age similar, 37 female, (84.1%) using the Student test, with P < 0.005 as significant.
  
  
  RESULTS
  Thirty-two patients (27 female (84.38%), 16-51 years, mean 40.41 +/- 7.8) were studied. Twenty-two patients (69%) had systolic blood pressure below 94 mmHg and 25 patients (78%) had diastolic blood pressure below 60 mmHg. Compared to normal, migraineurs exhibited a significantly higher vagal response (P < 0.001) and a significantly lower alpha sympathetic response, central by using ES as well as peripheral by using HG of 3 min (P < 0.001).
  
  
  CONCLUSIONS
  Autonomic cardiovascular reactivity of patients with migraine showed a vagal hyperactivity and a deficiency of the alpha sympathetic system. This leads to further studies with new therapeutical approaches.
authors.affiliation: Service de cardiologie A, CHU Ibn-Sina, Rabat, Maroc. benjellounhalima@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Benjelloun
authors.forename: N
authors.initials: N
authors.lastname: Birouk
authors.forename: I
authors.initials: I
authors.lastname: Slaoui
authors.forename: L
authors.initials: L
authors.lastname: Coghlan
authors.forename: B Oulad Amar
authors.initials: BO
authors.lastname: Bencheikh
authors.forename: I
authors.initials: I
authors.lastname: Jroundi
authors.forename: M
authors.initials: M
authors.lastname: Benomar
mesh_terms: D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*