title: [Hepatotoxicity caused by antituberculosis drugs in pediatrics].
abstract: The clinical profile of hepatotoxicity induced by tuberculosis drugs varies and the re-introduction of therapy for patients who developed this condition is controversial.5 pediatric cases treated throughout a period of 10 years in the Pediatric Department of Hipolito Unanue National Hospital are presented.2 individuals showed an asymptomatic increase of transaminases, 2 individuals had hepatitis, and 1 individual had acute liver failure. Most patients were female school students. Malnutrition and therapy continuation once the hepatic damage was started were found to be the risk factors.A staged reintroduction scheme for these agents after recovery from hepatitis is proposed.
authors.affiliation: Departamento de Pediatría del Hospital Nacional Hipólito Unanue.
authors.forename: Luz Victoria
authors.initials: LV
authors.lastname: Reto Valiente
authors.forename: José
authors.initials: J
authors.lastname: Castillo Vergara
authors.forename: Patricia
authors.initials: P
authors.lastname: Pichilingue Reto
authors.forename: Oscar Alfredo
authors.initials: OA
authors.lastname: Pichilingue Prieto
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies
chemical_list: D000995:Antitubercular Agents