[Survey of level of house dust mite specific IgE and interleukin-4 pre and post desensitization therapy].
OBJECTIVE
Survey the house dust mite specific IgE and interleukin-4's (IL-4) role in the desensitization therapy.


METHODS
Evaluate the effects of desensitization therapy. Determine the serum level of dl and IL-4 pre and post desensitization therapy, and then test of significance and correlative analysis were made.


RESULTS
There's significant difference between the levels of IL-4 pre and post therapy, and it has positive correlation with the symptom score. But there's no significant difference between the levels of dl pre and post therapy.


CONCLUSIONS
IL-4 plays a very important role in both of the pathogenesis of allergic rhinitis and the desensitization therapy. But specific IgE may just has the same effect in the pathogenesis.
Wang
Zhongxi
Z
Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. wangzhxl@yahoo.com.cn
D000293:Adolescent; D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D003888:Desensitization, Immunologic; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D039981:Pyroglyphidae / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000628:therapy; D055815:Young Adult
C508598:IL4 protein, human; D015847:Interleukin-4; D007073:Immunoglobulin E