Vocal fold wound healing: a review for clinicians.
The basic science of wound healing is largely omitted from the curriculum of many voice clinicians. This fact is relatively disheartening as most therapeutic manipulation in the realm of laryngology and voice disorders deals with injured tissue. Therefore, the selection of therapeutic tasks for persons with vocal injury should ideally be informed by basic science in wound healing. Recently, several investigators have initiated lines of research to determine the course of vocal fold wound healing and the potential role of therapeutic agents, including behavioral agents. The current review seeks to provide a foundation of basic wound healing science and present the most current data regarding the wound healing process in the vocal folds.
Branski
Ryan C
RC
Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. branskir@mskcc.org
Verdolini
Katherine
K
Sandulache
Vlad
V
Rosen
Clark A
CA
Hebda
Patricia A
PA
D005109:Extracellular Matrix / Q000502:physiology; D006097:Granulation Tissue; D006801:Humans; D006984:Hypertrophy; D007249:Inflammation / Q000503:physiopathology; D007820:Laryngeal Mucosa / Q000473:pathology; D007828:Laryngoscopy; D014827:Vocal Cords / Q000293:injuries* / Q000473:pathology; D014832:Voice Disorders / Q000209:etiology / Q000503:physiopathology*; D014945:Wound Healing / Q000502:physiology*