Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease.
We investigated cerebrospinal fluid (CSF) samples from patients with Creutzfeldt-Jakob disease (CJD) and other neurological diseases. Concentrations of pro- and anti-inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha and TGF-beta 2 were determined in CSF using ELISA. Significant changes were found for IL-8 and TGF-beta 2. IL-8 levels were elevated in the CSF of CJD patients. Of interest, the increase was significant to other dementia and to controls. In contrast, TGF-beta 2 was significantly decreased in CSF of CJD compared to all groups. IL-1beta, IL-12 and TNF-alpha could not be detected in CSF or in case of IL-6 in only low concentrations without significant difference.
Stoeck
Katharina
K
Department of Neurology, University of Göttingen, Robert-Koch Str.40, 37075 Göttingen, Germany.
Bodemer
Monika
M
Zerr
Inga
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000150:complications; D007562:Creutzfeldt-Jakob Syndrome / Q000097:blood / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D003704:Dementia / Q000134:cerebrospinal fluid / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004827:Epilepsy / Q000134:cerebrospinal fluid / Q000150:complications; D005260:Female; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid* / Q000209:etiology; D016209:Interleukin-8 / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D016212:Transforming Growth Factor beta / Q000097:blood / Q000134:cerebrospinal fluid*
D016209:Interleukin-8; D016212:Transforming Growth Factor beta