title: [Evaluation of peritoneal cytology in colorectal carcinoma].
abstract: We investigated the incidence of free cancer cells in the peritoneal washings of 278 patients who had undergone surgery for colorectal cancer to evaluate its influence as a prognostic factor of the disease. Twenty-two cases (7.9%) were found to have malignant positive cytology (CY(+)). The rate of CY(+) in the cases with peritoneal dissemination (P(+)) was significantly higher than that in P(-) (66.7% vs 3.8%). In 244 cases, those who had tumors exposing to the peritoneum, both CY(+) and P(+) were observed highly in poorly differentiated adenocarcinoma. Among 18 P(+) cases, the rates of CY(+) were higher in both P3 and cur C than in P1, 2 and cur B. When restricted to 260 P(-) cases, CY(+) was observed more often in stage IV cases (14.3% vs 1.8%). Rate was significantly high in M+ (66.7%). Prognosis of 4 P(-) CY(+) cur A cases was as follows; 2 survived for a long time with no recurrence (20 and 60 months), 1 had curable liver metastases after half a year and obtained a 2 year disease free period after surgery, and another one died with brain, liver, and peritoneal recurrence one year later. The incidence of CY(+) is correlated with P(+); CY(+) increased when P(+) is extended more highly and incurable. CY(+) alone doesn't become a prognostic factor for peritoneal recurrences, because CY(+) is found rarely in curable P(-) cases. However, CY(+) is also associated with far advanced cancer with remote metastases, therefore we should consider the risk of such metastases for CY(+) cases with curable colorectal cancer.
authors.affiliation: Dept of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation Ohkubo Hospital.
authors.forename: Kumi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Michio
authors.initials: M
authors.lastname: Maruyama
authors.forename: Shoji
authors.initials: S
authors.lastname: Maruyama
authors.forename: Nobuko
authors.initials: N
authors.lastname: Tamura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Miyawaki
authors.forename: Itaru
authors.initials: I
authors.lastname: Takashima
authors.forename: Ayaki
authors.initials: A
authors.lastname: Koide
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ebuchi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sakoma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001202:Ascitic Fluid / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary; D011379:Prognosis