title: Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families.
abstract: A genetic linkage map of the horse consisting of 742 markers, which comprises a single linkage group for each of the autosomes and the X chromosome, is presented. The map has been generated from two three-generation full-sibling reference families, sired by the same stallion, in which there are 61 individuals in the F2 generation. Each linkage group has been assigned to a chromosome and oriented with reference to markers mapped by fluorescence in situ hybridization. The average interval between markers is 3.7 cM and the linkage groups collectively span 2772 cM. The 742 markers comprise 734 microsatellite and 8 gene-based markers. The utility of the microsatellite markers for comparative mapping has been significantly enhanced by comparing their flanking sequences with the human genome sequence; this enabled conserved segments between human and horse to be identified. The new map provides a valuable resource for genetically mapping traits of interest in the horse.
authors.affiliation: Animal Health Trust, Newmarket, Suffolk CB8 7UU, UK.
authors.forename: June E
authors.initials: JE
authors.lastname: Swinburne
authors.forename: Mike
authors.initials: M
authors.lastname: Boursnell
authors.forename: Gemma
authors.initials: G
authors.lastname: Hill
authors.forename: Louise
authors.initials: L
authors.lastname: Pettitt
authors.forename: Twink
authors.initials: T
authors.lastname: Allen
authors.forename: Bhanu
authors.initials: B
authors.lastname: Chowdhary
authors.forename: Telhisa
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurosawa
authors.forename: Tosso
authors.initials: T
authors.lastname: Leeb
authors.forename: Suguru
authors.initials: S
authors.lastname: Mashima
authors.forename: James R
authors.initials: JR
authors.lastname: Mickelson
authors.forename: Terje
authors.initials: T
authors.lastname: Raudsepp
authors.forename: Teruaki
authors.initials: T
authors.lastname: Tozaki
authors.forename: Matthew
authors.initials: M
authors.lastname: Binns
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics*; D003433:Crosses, Genetic; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D015698:Genomic Library; D006736:Horses / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D010375:Pedigree; D019655:Quantitative Trait, Heritable
chemical_list: D005819:Genetic Markers