title: [Relationship between serum and placental interleukin-18 levels and preeclampsia].
abstract: To investigate the relationship of interleukin (IL)-18 concentrations in serum and placenta and preeclampsia.
  
  
  
  Twenty-seven patients with preeclampsia and 28 women with normal pregnancy were recruited. Blood and placenta samples were taken and serum and placental IL-18 concentrations were determined by enzyme-linked immunosorbent assay (ELISA). The levels of IL-18 in serum and placenta were compared.
  
  
  
  (1) The median of serum IL-18 in patients with preeclampsia was 704 ng/L, which was significantly higher than that of control group (470 ng/L, P<0.05). (2) The median of placental IL-18 in patients with preeclampsia was 105 ng/L, which was also significantly higher than that of control group (31.5 ng/L, P<0.005).
  
  
  
  Increased serum and placental levels of IL-18 were presented in preeclampsia as compared to normal pregnancy, which might offer insight into the pathogenesis of the disease.
authors.affiliation: The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Xia-di
authors.initials: XD
authors.lastname: Huang
authors.forename: He-feng
authors.initials: HF
authors.lastname: Huang
authors.forename: Min-yue
authors.initials: MY
authors.lastname: Dong
authors.forename: Qi-wei
authors.initials: QW
authors.lastname: Yao
authors.forename: Hang-zhi
authors.initials: HZ
authors.lastname: Wang
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood* / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D020382:Interleukin-18