title: Cost-minimization analysis of darbepoetin alfa versus epoetin alfa in the hospital setting.
abstract: OBJECTIVE
  The cost of darbepoetin alfa versus that of epoetin alfa in a hospital setting was studied.
  
  
  METHODS
  The study was an observational, retrospective review of the hospitalwide use of darbepoetin and epoetin during hospital admissions beginning in the period from January 2003 through April 2003. After the identification from daily charge reports of patients who used at least one of the study drugs during an admission, charts were requested for review. Drug product costs were determined from hospital purchasing information. Material and labor costs were combined to estimate drug administration costs. Total costs were calculated as the sum of drug product costs and administration costs.
  
  
  RESULTS
  A total of 429 epoetin records and 80 darbepoetin records were included. The two cohorts were similar with respect to demographic characteristics. With respect to costs, the only significant difference between cohorts was in daily administration costs, which were lower for patients receiving darbepoetin. Sensitivity analysis found lower costs for darbepoetin only after the dose-conversion ratio (DCR) was increased to above 256.74 units:1 microg. The overall DCR based on the median daily dose of each drug was 244.90 units:1 microg.
  
  
  CONCLUSIONS
  A cost-minimization study in a hospital showed no cost difference between treatment with epoetin and darbepoetin.
authors.affiliation: Methodist Hospital Pharmacy, Clarian Health Partners, Inc., Indianapolis, IN, USA. ekruep@yahoo.com
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Kruep
authors.forename: Lorne E
authors.initials: LE
authors.lastname: Basskin
mesh_terms: D000740:Anemia / Q000188:drug therapy*; D000068256:Darbepoetin alfa; D016527:Drug Costs; D000068817:Epoetin Alfa; D004921:Erythropoietin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000191:economics* / Q000627:therapeutic use; D006454:Hemoglobins / Q000378:metabolism; D017721:Hospital Costs; D006761:Hospitals; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy; D007902:Length of Stay; D009369:Neoplasms / Q000188:drug therapy; D011994:Recombinant Proteins
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; D000068256:Darbepoetin alfa; D000068817:Epoetin Alfa