title: Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro.
abstract: The root of Paeonia lactiflora and the stem of Sinomenium acutum are two herbs widely used in Chinese herbal medicine for the treatment of inflammatory and arthritic diseases. Studies on the interaction of the active constituents of these herbs, i.e., paeoniflorin and sinomenine, in pharmacokinetic parameters, tissues distribution, and protein binding ability could provide empirical data to support their clinical application. Following oral administration to rats, the pharmacokinetic alterations were compared. The results showed that the pharmacokinetic parameters (Cmax, Tmax, AUC, MRT, C(L), and Vd) of paeoniflorin were markedly enhanced when co-administrated with sinomenine. At 45 min after oral administration, the concentrations of paeoniflorin in the main internal organs were significantly increased when co-administrated with sinomenine. These phenomena were not ascribable to the alteration of the protein binding ability of paeoniflorin by sinomenine because obvious interactions of paeoniflorin and sinomenine in protein binding abilities in vitro to rat and rabbit plasma, human albumin, and alpha-1-acid-glycoprotein were not observed. However, with respect to the in vivo influence of paeoniflorin on sinomenine, the results showed that co-administration of paeoniflorin did not affect the pharmacokinetic parameters and tissue distribution of sinomenine.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
authors.forename: Zhong Qiu
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Zhi Hong
authors.initials: ZH
authors.lastname: Jiang
authors.forename: Kelvin
authors.initials: K
authors.lastname: Chan
authors.forename: Hua
authors.initials: H
authors.lastname: Zhou
authors.forename: Yuen Fan
authors.initials: YF
authors.lastname: Wong
authors.forename: Zhao Xiang
authors.initials: ZX
authors.lastname: Bian
authors.forename: Hong Xi
authors.initials: HX
authors.lastname: Xu
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000494:pharmacology*; D019540:Area Under Curve; D001565:Benzoates / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000493:pharmacokinetics* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis; D004347:Drug Interactions; D005960:Glucosides / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008297:Male; D039821:Monoterpenes; D009019:Morphinans / Q000493:pharmacokinetics* / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D015203:Reproducibility of Results; D014018:Tissue Distribution; D006027:Glycosides
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D001952:Bridged-Ring Compounds; D005960:Glucosides; D039821:Monoterpenes; D009019:Morphinans; C015423:peoniflorin; D006027:Glycosides; C009271:sinomenine