[Is there an association between the sleep apnea syndrome and the circadian peak of myocardial infarction in the morning hours?].
OBJECTIVE
To determine whether there is a relationship between the circadian rhythm of acute myocardial infarction (AMI) in the morning hours and the sleep apnea syndrome (SAS).


METHODS
203 patients who had sustained an AMI were examined 7-14 days later for sleep-associated breathing disorders using a 5-channel recording system. The diagnostic criterion for SAS was > 10 episodes of apnea and hypopnea per hour (AHI >10). 76 % of all patients were male, mean age 62 years.


RESULTS
SAS was diagnosed in 91 of the 203 patients (44.8 %). Compared to the 112 patients without SAS there were significantly more AMI in the morning hours (6:00 am to 12:00 am) in the SAS-group (49.5 %) than in the non-SAS-group (21.4 %). The two groups differed with regard to the symptoms of day-time sleepiness (29.7 % vs 17.0 %), age (mean 64.6 years vs 60.2 years), gender (83.5 % vs 69.9 % male) and smoking (33.0 % vs 51.8 %). There were no significant differences in Body mass index, hypertension, hyperlipoproteinemia, diabetes mellitus, family history, history of cardiovascular disease and taking of sedatives.


CONCLUSIONS
The strong association between SAS and morning onset of AMI found in this study could be the result of a sympathetic stress reaction to the breathing disorder.
Junker-Neff
A
A
1. Med. Abteilung, Rotkreuzkrankenhaus München.
Eberle
R
R
V Arnim
T
T
Mehilli
J
J
Hollweck
R
R
D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000503:physiopathology; D012907:Smoking / Q000453:epidemiology