Virology of hepatitis B and C viruses and antiviral targets.
Hepatitis B and C viruses belong to two distinct virus families, the Hepadnaviridae and the Flaviviridae, respectively, and have different virological characteristics. Better knowledge of their lifecycles and variability offers the opportunity to develop novel therapeutic approaches and classes of drugs. The issue of cccDNA clearance, however, remains in hepatitis B treatment, whereas HCV infection is curable.
Pawlotsky
Jean-Michel
JM
Department of Virology, INSERM U635, Hôpital Henri Mondor, Université Paris 12, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France. jean-michel.pawlotsky@hmn.aphp.fr
D000998:Antiviral Agents / Q000494:pharmacology*; D004279:DNA, Viral / Q000235:genetics; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D006509:Hepatitis B / Q000188:drug therapy / Q000821:virology*; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D006526:Hepatitis C / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D016133:Polymerase Chain Reaction; D014774:Virulence
D000998:Antiviral Agents; D004279:DNA, Viral