Secretion and expression of epithelial markers supports the biliary origin of solitary nonparasitic cyst of the liver in infancy.
Solitary nonparasitic cyst of the liver (SNPCL) is rare in children. Although there are several hypotheses regarding the pathogenesis, the true origin of SNPCL remains unknown. The authors present an infant with a huge SNPCL in whom the epithelial markers, CA19-9, DU-PAN-2, and SPan-1, were elevated in the serum and cystic fluid. The presence of CA19-9 and DU-PAN-2 was shown by immunohistochemistry in the cystic epithelia. These indicate that the classical idea of biliary origin of SNPCL is supported.
Otani
Yushi
Y
Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, Koshigaya, Saitama 343-8555, Japan.
Takayasu
Hajime
H
Ishimaru
Yuki
Y
Okamura
Kaori
K
Yamagishi
Junko
J
Ikeda
Hitoshi
H
D000951:Antigens, Neoplasm / Q000097:blood; D001659:Biliary Tract / Q000473:pathology*; D018395:CA-19-9 Antigen / Q000097:blood; D003560:Cysts / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008107:Liver Diseases / Q000473:pathology* / Q000601:surgery; D008297:Male
D000951:Antigens, Neoplasm; D018395:CA-19-9 Antigen; C042317:DU-PAN-2 antigen, human; C059729:pancreatic associated antigen, SPan-1