Altered oral absorption of alcohol by combined aqueous extracts of four herbal plants in rats.
This study examined the effect of combined aqueous extracts (BHR) of Ginko biloba, Mentha arvensis var. piperascens, Citrus unshiu, and Pueraria lobata var. chinensis on oral absorption of alcohol in rats. The rats were pretreated with BHR, placebo solution identical to BHR without the herbal extract, and isotonic saline. Alcohol was administered orally at 1- and 3-g/kg doses and the absorption profiles were compared. After oral administration of 1-g/kg doses, mean area under the curve (AUC) and C(max) values were significantly reduced in BHR-treated rats (16.1 +/- 10.0 and 0.3 +/- 0.1 mg/ml, respectively) as compared with saline-treated (37.9 +/- 14.4 and 0.7 +/- 0.7 mg/ml, respectively) and placebo solution-treated (63.0 +/- 46.4 and 0.7 +/- 0.4 mg/ml, respectively) rats. Similarly, after administration of 3-g/kg doses, mean AUC and C(max) values in BHR-treated rats (188.1 +/- 119.7 mg(.)min/ml and 1.0 +/- 0.4 mg/ml) were significantly reduced over those in saline-treated rats (571.4 +/- 512.4 mg(.)min/ml and 1.8 +/- 0.9 mg/ml, respectively). The relative oral bioavailability of alcohol calculated as the ratio of AUC(BHR)/AUC(Saline) was 42.5% and 32.9% at 1- and 3-g/kg doses, respectively. The reduced serum alcohol levels as well as the reduced AUC and C(max) after pretreatment with BHR appear to be a result of a reduced systemic absorption not due to an increased metabolic clearance.
Shin
Beom Soo
BS
College of Pharmacy, Sungkyunkwan University, Changan-gu, Suwon, Kyonggi-do, Korea.
Jun
Hun
H
Lee
Dong-Eok
DE
Lee
Kang Ro
KR
Park
Eun Seok
ES
Yoo
Sun Dong
SD
D000818:Animals; D002957:Citrus; D004338:Drug Combinations; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D020441:Ginkgo biloba; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D027541:Mentha; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D029908:Pueraria; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D010936:Plant Extracts; D000431:Ethanol