[Genetic linkage analysis in localizing a gene of autosomal dominant familial dilated cardiomyopathy with conduction defect].
OBJECTIVE
To localize the gene of autosomal dominant familial dilated cardiomyopathy with conduction defect.


METHODS
A Chinese family which was diagnosed as dilated cardiomyopathy with conduction defect was studied. Venous blood (3 - 5 mL) from some family members was collected, and genomic DNA was extracted from the blood. Then whole genome wide scan was performed after excluding the known markers on the candidate loci (CMD1A, CMD1 E, CMD1F, and CMD1H) by two-point linkage analysis.


RESULTS
No significant evidence for linkage was found in the two point linkage analyses to the known markers in the analyzed family. And the whole genome wide scan showed the maximum LOD score reached 2.68 at marker D3S1614 ( at recombination fraction theta = 0).


CONCLUSIONS
The related gene in this kindred is located on 3q26 other than on CMD1A, CMD1H, CMD1E, and CMD1F.
Xu
Wei
W
National Laboratory of Medical Genetics, Central South University, Changsha, China. nlmgley@xysm.net
Zhang
Bao-Rong
BR
Hu
Zheng-Mao
ZM
Pan
Qian
Q
Liu
Xiao-Ping
XP
Liang
De-Sheng
DS
Wu
Ling-Qian
LQ
Cai
Fang
F
Long
Zhi-Gao
ZG
Xia
Kun
K
Xia
Jia-Hui
JH
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000235:genetics*; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010375:Pedigree