[Behavior of intraocular pressure according to cardiorespiratory and hemodynamic effects induced by desflurane in dogs subjected to experimental hypovolemia].
OBJECTIVE
To observe the behavior of intraocular pressure according to the cardiopulmonary and hemodynamic effects induced by desflurane in dogs subjected to experimental hypovolemia.


METHODS
Eighteen healthy male and female mongrel dogs, weighing between 10 and 15 kg were used. Hypovolemia was induced by withdrawal of 40 ml blood/kg body weight. Then anesthesia was induced with desflurane by mask until tracheal intubation was permitted. Intraocular pressure was measured with applanation tonometry. Heart rate, cardiac output, mean arterial pressure, central venous pressure, end-tidal concentration of CO2 and respiratory rate were recorded. Parameters were registered after animal instrumentation and before any procedure in the awake dogs (T0), fifteen minutes after experimental hemorrhage induction (T45), and after thirty minutes of desflurane anesthesia (T75).


RESULTS
Intraocular pressure presented direct correlation only with pressure and end-tidal concentration of CO2.


CONCLUSIONS
It was not possible to establish a correlation between alterations of mean arterial pressure and central venous pressure and intraocular pressure and there was a direct relationship between values of intraocular pressure and values of exhaled CO2.
Talieri
Ivia Carmem
IC
Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP. iviact@ig.com.br
Honsho
Cristiane dos Santos
Cdos S
Nunes
Newton
N
Souza
Almir Pereira de
AP
Duque
Juan Carlos
JC
D000704:Analysis of Variance; D000758:Anesthesia / Q000662:veterinary; D018685:Anesthetics, Inhalation / Q000627:therapeutic use*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D000077335:Desflurane; D004285:Dogs / Q000601:surgery*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D020896:Hypovolemia / Q000503:physiopathology* / Q000662:veterinary; D007429:Intraocular Pressure / Q000187:drug effects* / Q000502:physiology; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male
D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane