title: Efavirenz 600 mg/day versus efavirenz 800 mg/day in HIV-infected patients with tuberculosis receiving rifampicin: 48 weeks results.
abstract: The potential of drug-drug interaction between efavirenz and rifampicin is a major concern in the treatment of HIV and tuberculosis. The optimal efavirenz dosage is still unclear. Our randomized control trial study recently reported the similar efavirenz level between efavirenz 600 and 800 mg/day in HIV-infected patients receiving rifampicin. We report the similar virological and immunological outcomes at 48 weeks between the two groups. Efavirenz 600 mg/day should be sufficient for concurrent use with rifamipicin.
authors.affiliation: Bamrasnaradura Institute, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Weerawat
authors.initials: W
authors.lastname: Manosuthi
authors.forename: Sasisopin
authors.initials: S
authors.lastname: Kiertiburanakul
authors.forename: Somnuek
authors.initials: S
authors.lastname: Sungkanuparph
authors.forename: Kiat
authors.initials: K
authors.lastname: Ruxrungtham
authors.forename: Asda
authors.initials: A
authors.lastname: Vibhagool
authors.forename: Sasivimol
authors.initials: S
authors.lastname: Rattanasiri
authors.forename: Ammarin
authors.initials: A
authors.lastname: Thakkinstian
mesh_terms: D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D048588:Benzoxazines; D001835:Body Weight / Q000276:immunology; D003521:Cyclopropanes; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D010078:Oxazines / Q000008:administration & dosage*; D012293:Rifampin / Q000627:therapeutic use*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D000904:Antibiotics, Antitubercular; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; C098320:efavirenz; D012293:Rifampin