[Incidence and predictors of thyroid dysfunction caused by long-term intake of amiodaron].
OBJECTIVE
To analyze occurrence of thyroid dysfunction due to regular long-term intake of amiodaron (for one year), to search for predictors of amiodaron-induced hypothyroidism and thyrotoxicosis.


METHODS
Sixty two patients with different types of arrhythmia have undergone examination including tests for TTH (once in three months), free T3 and T4 (once in 6 months), ultrasound thyroid investigation, general clinical and physical check-up, resting ECG in 12 leads, echocardiography, chest x-ray, biochemical blood tests, blood count, urinalysis.


RESULTS
Amiodaron intake for 1 year was associated with amiodaron-induced thyroid dysfunction in 25% patients: 19.2% developed hypothyroidism, 5.8%--thyrotoxicosis. Organic pathology of cardiovascular system, cardiac failure, left ventricular aneurysms, low global myocardial contractility, organic thyroid pathology, elevated levels of antithyroid antibodies predicted hypothyroidism. Thyrotoxicosis was associated with a young age and male sex.


CONCLUSIONS
Amiodaron may cause thyroid dysfunction in patients with arrhythmia.
Serdiuk
S E
SE
Bakalov
S A
SA
Golitsyn
S P
SP
Molashenko
N V
NV
Platonova
N M
NM
Sviridenko
N Iu
NIu
D000367:Age Factors; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000517:prevention & control; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012737:Sex Factors; D013959:Thyroid Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013971:Thyrotoxicosis / Q000139:chemically induced / Q000517:prevention & control; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
D000889:Anti-Arrhythmia Agents; D014284:Triiodothyronine; D013972:Thyrotropin; D000638:Amiodarone; D013974:Thyroxine