title: T-Taxol and the electron crystallographic density in beta-tubulin.
abstract: [chemical structure: see text]. T-Taxol has been proposed as the bioactive conformation on beta-tubulin and subsequently utilized in the design of a series of highly active bridged taxane analogues. A modified T-form with a reversed C-13 side chain orientation has recently been proposed as an equally plausible bioactive shape. A comparison of the two spatial alternatives within the tubulin binding site electron crystallographic density suggests strongly that T-Taxol is the bioactive conformation.
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Johnson
authors.forename: Ana A
authors.initials: AA
authors.lastname: Alcaraz
authors.forename: James P
authors.initials: JP
authors.lastname: Snyder
mesh_terms: D001665:Binding Sites; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry*; D014404:Tubulin / Q000737:chemistry*
chemical_list: D014404:Tubulin; D017239:Paclitaxel