title: Evidence for sensory prediction deficits in schizophrenia.
abstract: OBJECTIVE
  Patients with schizophrenia experiencing delusions and hallucinations can misattribute their own actions to an external source. The authors test the hypothesis that patients with schizophrenia have defects in their ability to predict the sensory consequences of their actions.
  
  
  METHODS
  The authors measured sensory attenuation of self-produced stimuli by patients with schizophrenia and by healthy subjects.
  
  
  RESULTS
  Patients with schizophrenia demonstrated significantly less sensory attenuation than healthy subjects.
  
  
  CONCLUSIONS
  Patients with a diagnosis of schizophrenia have a dysfunction in their predictive mechanisms.
authors.affiliation: Institute of Neurology, University College London. s.shergill@iop.kcl.ac.uk
authors.forename: Sukhwinder S
authors.initials: SS
authors.lastname: Shergill
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Samson
authors.forename: Paul M
authors.initials: PM
authors.lastname: Bays
authors.forename: Chris D
authors.initials: CD
authors.lastname: Frith
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Wolpert
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology; D003702:Delusions / Q000175:diagnosis / Q000523:psychology; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D011601:Psychophysics; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D020886:Somatosensory Disorders / Q000175:diagnosis* / Q000523:psychology; D014110:Touch / Q000502:physiology*