Aerobic oxidative cyclization under Pd(II) catalysis: a regioselective approach to heterocycles.
[chemical reaction: see text]. An efficient Yb(OTf)3-promoted palladium-catalyzed oxidative cyclization of gamma-heteroalkenyl beta-keto amides has been developed. Under simple aerobic condition, a variety of six-, seven-, and eight-membered-ring N- and O-heterocycles were obtained regioselectively in excellent yield.
Yip
Kai-Tai
KT
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.
Li
Jin-Heng
JH
Lee
On-Yi
OY
Yang
Dan
D