Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.
The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.
Christian
Omar E
OE
Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.
Compton
Jennifer
J
Christian
Keisha R
KR
Mooberry
Susan L
SL
Valeriote
Fredrick A
FA
Crews
Phillip
P
D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D047630:Depsipeptides / Q000494:pharmacology*; D026121:Indole Alkaloids; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera
D047630:Depsipeptides; D026121:Indole Alkaloids; D007211:Indoles; C057531:jasplakinolide; C019290:chaetoglobosins