title: Spontaneous rupture of recurrent gastrointestinal stromal tumor associated with neurofibromatosis type 1.
abstract: The incidence of gastrointestinal stromal tumor (GIST) among neurofibromatosis type 1 (NF-1) patients is approximately 3.9-25%, and this relationship is generally considered to be non-coincidental. We report a patient with NF-1 who underwent laparotomy 3 times due to recurrent intra-abdominal tumor rupture with internal bleeding in the space of 13 years. The pathologic diagnoses were schwannoma, malignant peripheral nerve sheath tumor and GIST. Because of the similar histologic features of these tumors, we considered them to be of the same nature. Immunohistochemical staining can help in the differential diagnosis. We suggest that NF-1 patients with gastrointestinal symptoms receive further survey to rule out GISTs.
authors.affiliation: Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC.
authors.forename: Shin-Mae
authors.initials: SM
authors.lastname: Wang
authors.forename: Ruey-An
authors.initials: RA
authors.lastname: Chiang
authors.forename: Chin-Yuan
authors.initials: CY
authors.lastname: Tzen
authors.forename: Shih-Ping
authors.initials: SP
authors.lastname: Cheng
authors.forename: Tsang-Pai
authors.initials: TP
authors.lastname: Liu
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009456:Neurofibromatosis 1 / Q000150:complications*; D012422:Rupture, Spontaneous; D015996:Survival Rate
chemical_list: D018952:Antigens, CD34