title: PCDD/F and PCB transfer to milk in goats exposed to a long-term intake of contaminated hay.
abstract: The purpose of this study was to determine the feed to milk transfer of 17 PCDD/Fs and 18 PCBs in goats exposed to a 10-week long-term intake of contaminated hay collected in the vicinity of a hazardous municipal waste incinerator. The sum of PCDD/Fs and PCBs WHO-I-TEQ was found to be higher than 3 ng kg(-1) of milk fat after the first experimental week. Carry-over rates (CORs) of PCDD/Fs and PCBs could be established at steady state conditions for each compound studied. For PCDD/Fs, 2,3,7,8-TCDD appeared as the compound having the highest COR (38.8%). Within dioxin-like-PCBs the highest COR were found at a similar level (higher than 80%) for PCBs 105, 118 and 157. Concerning indicator-PCBs, COR ranged from 5% (PCB 101) to more than 40% (PCBs 118, 153 and 180). The intensity of this transfer appeared to be a function of physico-chemical properties (chlorination or logK(ow)) of the molecules and their metabolic behaviour.
authors.affiliation: URAPA, INRA-INPL-UHP, 2 Avenue de la Forêt de Haye, 54505 Vandoeuvre-Lès-Nancy Cedex, France.
authors.forename: Adrián
authors.initials: A
authors.lastname: Costera
authors.forename: Cyril
authors.initials: C
authors.lastname: Feidt
authors.forename: Philippe
authors.initials: P
authors.lastname: Marchand
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
authors.forename: Guido
authors.initials: G
authors.lastname: Rychen
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001572:Benzofurans / Q000032:analysis / Q000493:pharmacokinetics; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000032:analysis* / Q000493:pharmacokinetics; D005260:Female; D005506:Food Contamination; D006041:Goats; D018811:Maternal Exposure; D008892:Milk / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000493:pharmacokinetics; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000032:analysis / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls