title: Antimicrobial azaphilones from the fungus Hypoxylon multiforme.
abstract: Four new azaphilones named multiformins A - D together with a known compound 4 : 5:4':5'-tetrahydroxy-1 : 1'-binaphthyl were isolated from the methanolic stromatal extract of the xylariaceous ascomycete Hypoxylon multiforme. Their absolute structures were characterised by 2D-NMR, UV, IR, mass and CD spectroscopy. Multiformins A - D showed strong and apparently non-selective antimicrobial activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: Dang Ngoc
authors.initials: DN
authors.lastname: Quang
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Marc
authors.initials: M
authors.lastname: Stadler
authors.forename: Niko
authors.initials: N
authors.lastname: Radulović
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D003904:Mitosporic Fungi / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010860:Pigments, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone