title: [A case of intraperitoneal paclitaxel administration in a gastric cancer patient with severely impaired renal function].
abstract: This study was designed to evaluate the pharmacokinetics and toxicity of paclitaxel, administered via an intraperitoneal route for a gastric cancer patient with renal dysfunction. The patient was a woman in her 50's, who had been diagnosed with severe renal dysfunction but no treatment history was known. She complained of dyspnea for a large quantity of ascites and was urgently hospitalized. It was diagnosed as gastric cancer with peritoneal dissemination. At this hospital, PTX was administered weekly intraperitoneally through an infusion port without complication. This result suggested that intraperitoneal PTX chemotherapy for a patient with renal dysfunction was a safe treatment.
authors.affiliation: Dept of Surgery, Tokyo Metropolitan Toshima Hospital.
authors.forename: Masahide
authors.initials: M
authors.lastname: Ohbu
authors.forename: Michio
authors.initials: M
authors.lastname: Maruyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Miyawaki
authors.forename: Nobuko
authors.initials: N
authors.lastname: Tamura
authors.forename: Ayaki
authors.initials: A
authors.lastname: Koide
authors.forename: Kumi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Shouji
authors.initials: S
authors.lastname: Maruyama
authors.forename: Itaru
authors.initials: I
authors.lastname: Takashima
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ebuchi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D001201:Ascites / Q000150:complications; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007674:Kidney Diseases / Q000150:complications*; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel