Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center.
Aspergillus isolates (n = 103) collected from cancer patients were screened to determine the taxonomic distribution and quantity of gliotoxin production. Gliotoxin was detected in 93% of Aspergillus fumigatus, 75% of A. niger, 25% of A. terreus, and 4% of A. flavus cultures. Gliotoxin concentrations were highest in cultures of A. fumigatus.
Lewis
Russell E
RE
University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund St. #423, Houston, TX 77030, USA. rlewis@uh.edu
Wiederhold
Nathan P
NP
Lionakis
Michail S
MS
Prince
Randall A
RA
Kontoyiannis
Dimitrios P
DP
D001228:Aspergillosis / Q000453:epidemiology* / Q000382:microbiology*; D001230:Aspergillus / Q000145:classification* / Q000254:growth & development / Q000302:isolation & purification*; D003470:Culture Media; D005912:Gliotoxin / Q000096:biosynthesis*; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D013045:Species Specificity
D003470:Culture Media; D005912:Gliotoxin