Identification of heavy metal complexes of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a voltammetric approach.
Complexation of the hexapeptide Hys-Cys-Lys-Phe-Trp-Trp, inhibitor of the human immunodeficiency virus integrase protein, with the heavy metal ions Cd2+, Pb2+, and Zn2+ has been investigated using differential pulse polarography. In the case of Pb2+, no significant complexation is detected, whereas in the cases of Cd2+ and Zn2+, strong and electrochemically inert ML2 complexes predominate. In contrast, ML complexes are present in a low proportion or are absent. When possible, the corresponding conditional stability constants have been determined at both pH 7.0 and pH 7.5, showing that Zn2+ complexes are slightly more stable than Cd2+ complexes.
Chekmeneva
Elena
E
Departament de Química Analítica, Facultat de Química, Universitat de Barcelona, E-08028 Barcelona, Spain.
Díaz-Cruz
José Manuel
JM
Ariño
Cristina
C
Esteban
Miquel
M
D002104:Cadmium / Q000737:chemistry*; D019428:HIV Integrase Inhibitors / Q000737:chemistry*; D007854:Lead / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D011048:Polarography; D015032:Zinc / Q000737:chemistry*
D019428:HIV Integrase Inhibitors; D009842:Oligopeptides; D002104:Cadmium; D007854:Lead; D015032:Zinc