The Shiga toxin 1-converting bacteriophage BP-4795 encodes an NleA-like type III effector protein.
In this study, the complete DNA sequence of Shiga toxin 1-converting bacteriophage BP-4795 was determined. The genome of BP-4795 consists of 85 open reading frames, including two complete IS629 elements and three morons at the end of its late regulatory region. One of these morons encodes a type III effector that is translocated by the locus of enterocyte effacement-encoded type III secretion system into HeLa cells, where it localizes with the Golgi apparatus.
Creuzburg
Kristina
K
Institute of Medical Microbiology and Hygiene, Technical University of Dresden, 01307 Dresden, Germany.
Recktenwald
Jürgen
J
Kuhle
Volker
V
Herold
Sylvia
S
Hensel
Michael
M
Schmidt
Herbert
H
D001483:Base Sequence; D003090:Coliphages / Q000235:genetics*; D004251:DNA Transposable Elements; D016679:Genome, Viral; D006056:Golgi Apparatus / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D021381:Protein Transport; D017422:Sequence Analysis, DNA; D017906:Siphoviridae / Q000235:genetics*; D014764:Viral Proteins / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D037521:Virulence Factors / Q000032:analysis / Q000235:genetics* / Q000378:metabolism
D004251:DNA Transposable Elements; D014764:Viral Proteins; D037521:Virulence Factors