title: Brain tumor-like lesion in Behçet disease.
abstract: We report a patient with longstanding Behçet disease who presented sudden onset of headache and facial paresis. The magnetic resonance imaging (MRI) showed a mass in the right thalamus, extending to the lentiform nucleus, subthalamic area, right cerebral peduncle and deep subcortical white matter. Stereotactic brain biopsy disclosed gliosis with no signs of malignancy. The diagnosis of a pseudotumoral form of neuro-Behçet disease was done and she was treated with pulse methylpredinisolone and intravenous cyclophosphamide. After 8 weeks she had improved and a new MRI showed disappearance of the tumor-like lesion. The differential diagnosis, especially with central nervous system tumor is emphasized.
authors.affiliation: Department of Rheumatology, State University of Campinas, Campinas, Brazil. appenzel@unicamp.br
authors.forename: Simone
authors.initials: S
authors.lastname: Appenzeller
authors.forename: Rafael
authors.initials: R
authors.lastname: de Castro
authors.forename: Luciano de Souza
authors.initials: Lde S
authors.lastname: Queiroz
authors.forename: Luciana
authors.initials: L
authors.lastname: Madegan
authors.forename: Cinira
authors.initials: C
authors.lastname: Soledade
authors.forename: Verônica de Araújo
authors.initials: Vde A
authors.lastname: Zanardi
authors.forename: Anamarli
authors.initials: A
authors.lastname: Nucci
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Sandra Regina M
authors.initials: SR
authors.lastname: Fernandes
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy; D001932:Brain Neoplasms / Q000175:diagnosis; D016543:Central Nervous System Neoplasms / Q000175:diagnosis; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008636:Mesencephalon / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone