Transient clonal expansion of T-large granular lymphocytes during primary cytomegalovirus infection.
Clonal immunoglobulin and T-cell receptor gene rearrangements are useful in distinguishing reactive lymphoproliferations from neoplastic processes. Here, we report a case of transient clonal expansion of CD8+ CD57- T-large granular lymphocytes (T-LGL) during primary cytomegalovirus infection. This case underlines that clonal expansion of T-LGL could be a reactive phenomenon related to an acute infectious disease and is not specific for lymphoid malignancy.
Delobel
Pierre
P
Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Dr Baylac, TSA 40031, 31059 Cedex 9, Toulouse, France. pierredelobel@yahoo.fr
Godel
Aurélie
A
Thebault
Sophie
S
Alric
Laurent
L
Duffaut
Michel
M
D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D002455:Cell Division; D002999:Clone Cells / Q000166:cytology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D008875:Middle Aged
D006684:HLA-DR Antigens