The RsbRST stress module in bacteria: a signalling system that may interact with different output modules.
In the Gram-positive bacterium Bacillus subtilis, the activity of the alternative sigma factor sigma(B) is triggered upon exposure of the bacteria to environmental stress conditions or to nutrient limitation. sigma(B) activity is controlled by protein-phosphorylation-dependent interactions of anti-sigma with anti-anti-sigma factors. Under stress conditions, the phosphatase RsbU triggers release of sigma(B) and thus induces the expression of stress genes. RsbU activity is controlled by three proteins, RsbR, RsbS and RsbT which form a supramolecular complex called the stressosome. Here we review the occurrence of the genes encoding the stressosome proteins (called the RsbRST module) in a wide variety of bacteria. While this module is linked to the gene encoding sigma(B) and its direct regulators in B. subtilis and its close relatives, genes encoding two-component regulatory systems and more complex phosphorelays are clustered with the RsbRST module in bacteria as diverse as cyanobacteria, bacteroidetes, proteobacteria, and deinococci. The conservation of the RsbRST module and its clustering with different types of regulatory systems suggest that the stressosome proteins form a signal sensing and transduction unit that relays information to very different output modules.
Pané-Farré
Jan
J
Institut für Mikrobiologie, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Deutschland.
Lewis
Richard J
RJ
Stülke
Jörg
J
D001412:Bacillus subtilis / Q000502:physiology*; D001426:Bacterial Proteins / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial; D010750:Phosphoproteins / Q000502:physiology; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D012808:Sigma Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D001426:Bacterial Proteins; D010750:Phosphoproteins; C119218:RsbR protein, Bacillus subtilis; D012808:Sigma Factor; C119219:RsbT protein, Bacillus subtilis; D017346:Protein Serine-Threonine Kinases; D010744:Phosphoric Monoester Hydrolases; C091162:RsbU protein, Bacillus subtilis