tRNA-isoleucine-tryptophan composite gene.
Transfer-RNA genes in archaea often have introns intervening between exon sequences. The structural motif at the boundary between exon and intron is the bulge-helix-bulge. Computational investigations of these boundary structures in Haloarcula marismortui lead us to propose that tRNA-isoleucine and tRNA-tryptophan genes are co-located. Precise in silico identification of the splice-sites on the bulges at the exon-intron boundaries lead us to infer that a single intron-containing composite tRNA-gene can give rise to more than one gene product.
Ghosh
Zhumur
Z
Computational Biology Group, Theory Department, Indian Association for the Cultivation of Science, Calcutta 700032, India.
Chakrabarti
Jayprokas
J
Mallick
Bibekanand
B
Das
Smarajit
S
Sahoo
Satyabrata
S
Sethi
Harmeet Singh
HS
D000818:Animals; D001483:Base Sequence; D005091:Exons; D019766:Genes, Archaeal; D019614:Haloarcula marismortui / Q000235:genetics*; D007438:Introns; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012346:RNA, Transfer, Amino Acyl / Q000235:genetics*
D012346:RNA, Transfer, Amino Acyl