title: Nonbacterial thrombotic endocarditis after lung transplantation.
abstract: Bacteria-free verrucae has been recognized as a condition associated with several clinical conditions such as bone marrow transplantation, malignant tumors, autoimmune disorders, and acquired immunodeficiency syndrome, but it has not been reported in relation to lung transplantation. We report the case of a patient who underwent bilateral lung transplant and died 3 days later. Histologic examination revealed, among other lesions, the presence of nonbacterial thrombotic endocarditis in the right atrium and mitral and tricuspid valves that was not present in the preoperative echocardiographic studies. Even with transesophageal echocardiography, a reliable detection of vegetations may not be possible. Hypoxigenic pulmonary states developed in the course of lung transplant could be the factor that triggers the interaction between the coagulation system, platelets, and endothelial cells that induce the formation of bacteria-free verrucae.
authors.affiliation: Services of Intensive Care, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Miñambres
authors.forename: Antonio M
authors.initials: AM
authors.lastname: González
authors.forename: Marta
authors.initials: M
authors.lastname: Mayorga
authors.forename: Felipe
authors.initials: F
authors.lastname: Zurbano
authors.forename: Genaro
authors.initials: G
authors.lastname: Díaz-Regañón
mesh_terms: D017548:Echocardiography, Transesophageal; D004696:Endocarditis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology