title: Concurrent chemo-radiotherapy with taxotere and cisplatin in head and neck cancer: a feasibility study.
abstract: BACKGROUND
  For many years surgery was the cornerstone of treatment for head and neck cancers and radiotherapy was the treatment of choice in adjuvant and advanced inoperable settings. Recently, induction sequential chemotherapy followed by radiotherapy has shown good tolerability and has prolonged the median overall survival. This phase II trial explored the feasibility of the concurrent association with radiotherapy of a full-dose chemotherapy based on an original schedule of docetaxel and cisplatin.
  
  
  METHODS
  Twenty-four patients with head and neck squamous cell carcinoma (HNSCC) were enrolled. Taxotere (docetaxel) was administered on day 1, weekly for 6 weeks. The dose was 33 mg/m2 /w. Cisplatin was administered on day 2 at the dose of 70 mg/m2. Radiotherapy delivered was 60 Gy divided in 30 administrations over 6 weeks.
  
  
  CONCLUSIONS
  This schedule of treatment for HNSCC proved feasible. Appropriate support treatment, however, appears to be necessary for the feasibility of this concurrent chemo-radiotherapy.
authors.affiliation: Oncology Unit Villa Scassi Hospital, Corso Onofrio Scassi, 1 16100 Genoa, Italy. manlio.mencoboni@fastwebnet.it
authors.forename: M
authors.initials: M
authors.lastname: Mencoboni
authors.forename: L
authors.initials: L
authors.lastname: Rebella
authors.forename: S
authors.initials: S
authors.lastname: Tredici
authors.forename: R
authors.initials: R
authors.lastname: Ghio
authors.forename: D
authors.initials: D
authors.lastname: Scarpati
authors.forename: M
authors.initials: M
authors.lastname: Bavazzano
authors.forename: B
authors.initials: B
authors.lastname: Jankowska
authors.forename: M
authors.initials: M
authors.lastname: Delle Piane
mesh_terms: D000368:Aged; D000740:Anemia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D000077143:Docetaxel; D005240:Feasibility Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin