title: Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.
abstract: The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.
authors.affiliation: Department of Clinical Haematology, Aberdeen Royal Infirmary, Aberdeen, UK. sajjanmittal@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Mittal
authors.forename: B J
authors.initials: BJ
authors.lastname: Milner
authors.forename: M A
authors.initials: MA
authors.lastname: Vickers
mesh_terms: D000328:Adult; D002999:Clone Cells / Q000473:pathology; D015329:Gene Rearrangement, T-Lymphocyte; D019674:Genes, T-Cell Receptor beta; D019675:Genes, T-Cell Receptor gamma; D006801:Humans; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000209:etiology; D013163:Splenomegaly / Q000209:etiology*; D013601:T-Lymphocytes / Q000473:pathology*