Dendrimer-drug interactions.
The interaction between drugs and dendrimers is reviewed with particular reference to the entrapment of drugs within the dendrimer architecture and the electrostatic and covalent complexation of drugs to the dendrimer surface. The application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability and the use of the complexes as vehicles for the controlled release of drugs and drug targeting is discussed.
D'Emanuele
Antony
A
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PL, UK. Antony@DEmanuele.net
Attwood
David
D
D050091:Dendrimers / Q000737:chemistry*; D004339:Drug Compounding; D004563:Electrochemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry
D050091:Dendrimers; D004364:Pharmaceutical Preparations; D011092:Polyethylene Glycols