[Brain edema and aquaporin].
Aquaporin is a membrane-bound water channel and highly related to the development and resolution of brain edema. We have detected mRNA and protein expression of aquaporin-4 in ischemic and traumatic brain injury. The aquaporin-4 expression is related to the resolution of brain edema rather than the evolution of the edema. We also detected the relation of aquaporin-1 expression and the evolution of hydrocephalus. Regulation of aquaporin function may be a new venue of treatment in brain edema.
Yamada
Kazuo
K
Department of Neurosurgery, Nagoya City University, 1 Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan. kyamada@med.nagoya-u.ac.jp
D000818:Animals; D051401:Aquaporin 4 / Q000502:physiology*; D001812:Blood-Brain Barrier / Q000503:physiopathology; D001929:Brain Edema / Q000503:physiopathology*; D006801:Humans
D051401:Aquaporin 4