title: Determination of ruthenium in pharmaceutical compounds by graphite furnace atomic absorption spectroscopy.
abstract: A graphite furnace atomic absorption (GFAA) spectrometric method for the determination of ruthenium (Rh) in solid and liquid pharmaceutical compounds has been developed. Samples are dissolved or diluted in dimethyl sulfoxide (DMSO) without any other treatment before they were analyzed by GFAA with a carefully designed heating program to avoid pre-atomization signal loss and to achieve suitable sensitivity. Various inorganic and organic solvents were tested and compared and DMSO was found to be the most suitable. In addition, ruthenium was found to be stable in DMSO for at least 5 days. Spike recoveries ranged from 81 to 100% and the limit of quantitation (LOQ) was determined to be 0.5 microg g(-1) for solid samples or 0.005 microg ml(-1) for liquid samples based a 100-fold dilution. The same set of samples was also analyzed by ICP-MS with a different sample preparation method, and excellent agreement was achieved.
authors.affiliation: Analytical Research Department, Merck Research Laboratories, P.O. Box 2000, RY80L-115, Rahway, NJ 07065-0900, USA. xiujuan_jia@merck.com
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Jia
authors.forename: Tiebang
authors.initials: T
authors.lastname: Wang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Bu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tu
authors.forename: Sandra
authors.initials: S
authors.lastname: Spencer
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D013058:Mass Spectrometry; D015203:Reproducibility of Results; D012428:Ruthenium / Q000032:analysis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012997:Solvents / Q000737:chemistry; D013054:Spectrophotometry, Atomic / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
chemical_list: D012997:Solvents; D006108:Graphite; D012428:Ruthenium; D004121:Dimethyl Sulfoxide