An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.
Disruption of the aflatoxin biosynthesis cluster gene aflY (hypA) gave Aspergillus parasiticus transformants that accumulated versicolorin A. This gene is predicted to encode the Baeyer-Villiger oxidase necessary for formation of the xanthone ring of the aflatoxin precursor demethylsterigmatocystin.
Ehrlich
Kenneth C
KC
SRRC/ARS/USDA, 1100 R. E. Lee Blvd., P.O. Box 19687, New Orleans, LA 70179, USA. ehrlich@srrc.ars.usda.gov
Montalbano
Beverly
B
Boué
Stephen M
SM
Bhatnagar
Deepak
D
D000348:Aflatoxins / Q000096:biosynthesis / Q000235:genetics*; D000880:Anthraquinones / Q000378:metabolism*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D017931:DNA Primers; D005658:Fungi / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D016133:Polymerase Chain Reaction / Q000379:methods; D013241:Sterigmatocystin / Q000096:biosynthesis*
D000348:Aflatoxins; D000880:Anthraquinones; D017931:DNA Primers; D013241:Sterigmatocystin; C029826:versicolorin A