[Change in pain reaction by combined action of nitric oxide modulators and low intensity electromagnetic field].
In experiments on mice with the tonic pain caused by introduced of 5% of formalin in hindpaw, are quantitatively measure changes of painful behavioural reaction (PBR) values under action low intensity electromagnetic field (EMF) and substances that modulate activity of NO-synthase system, and at both of these action also. Such substances were used: in quality inhibitor NO-synthase--Nw-nitro-L-arginin (L-NAME), donors NO--sodium nitroprusside (SNP) and sodium nitrite (SN). Influence of the EMF completely eliminated effect of the L-NAME and SN in concentration of 0.5 mM/l, and also SNP in concentration 5 mcM/l on the painful reaction. The assumption that neurogenetics and NO- ergic mechanisms are basis of the systems analgesic effects of the low intensity electromagnetic fields. Mechanisms of modulation of painful behavioural reaction and other behavioural displays of animals under condition EMF and NO are discussed.
Sushko
B S
BS
Lymans'kyĭ
Iu P
IuP
D000818:Animals; D021461:Animals, Outbred Strains; D003131:Combined Modality Therapy; D004574:Electromagnetic Fields; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005557:Formaldehyde / Q000494:pharmacology; D051379:Mice; D019331:NG-Nitroarginine Methyl Ester / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000627:therapeutic use; D009599:Nitroprusside / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D059408:Pain Management; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D012977:Sodium Nitrite / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D020030:Nitric Oxide Donors; D009599:Nitroprusside; D005557:Formaldehyde; D009569:Nitric Oxide; D012977:Sodium Nitrite; D019331:NG-Nitroarginine Methyl Ester