title: Hydrogen bond catalyzed enantioselective vinylogous Mukaiyama aldol reaction.
abstract: [chemical reaction: see text]. The concept of hydrogen bonding catalysis was extended to the vinylogous Mukaiyama aldol reaction, which gives rapid access to polyketide derivatives. The reaction of the silyldienol ether shown and a range of aldehydes catalyzed by TADDOL proceeds regiospecifically to produce the addition products in good yields and enantiomeric excesses.
authors.affiliation: Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Vijaya Bhasker
authors.initials: VB
authors.lastname: Gondi
authors.forename: Michel
authors.initials: M
authors.lastname: Gravel
authors.forename: Viresh H
authors.initials: VH
authors.lastname: Rawal
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D006860:Hydrogen Bonding; D018942:Macrolides / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D018942:Macrolides; D012821:Silanes