Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.
Two new hirsutane sesquiterpenes, connatusins A (1) and B (2), were isolated from the fungus Lentinus connatus BCC 8996. The structures, closely related to hypnophilin, were elucidated on the basis of the spectroscopic data. An X-ray analysis was performed to confirm the structure of 1. Six known compounds were also obtained. Panepoxydone (5), panepoxydione (6), and dihydrohypnophilin (8) exhibited significant antimalarial and cytotoxic activities.
Rukachaisirikul
Vatcharin
V
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. vatcharin.r@psu.ac.th
Tansakul
Chittreeya
C
Saithong
Saowanit
S
Pakawatchai
Chaveng
C
Isaka
Masahiko
M
Suvannakad
Rapheephat
R
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D020074:Lentinula / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand
D000962:Antimalarials; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C506499:connatusin A; C506500:connatusin B