[Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound].
OBJECTIVE
To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT.


METHODS
Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum.


RESULTS
Inclusion ratio of CT versus HPCD was 1:1. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug.


CONCLUSIONS
Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.
Luo
Xin
X
School of Pharmaceutical Sciences, Sun Yet-sen University, Guangzhou 510080, China.
Xu
Yue-hong
YH
Chen
Bao
B
Gu
Lian-quan
LQ
Huang
Min
M
Liu
Pei-qing
PQ
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D001682:Biological Availability; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C037886:cryptotanshinone