title: Rapid deprotection of N-Boc amines by TFA combined with freebase generation using basic ion-exchange resins.
abstract: The deprotection of N-Boc amines was rapidly accomplished using 5 equivalents of TFA in methylene chloride in a focused microwave instrument with irradiation at 60 degrees C for 30 min. The freebase amines are then obtained by scavenging the crude reaction mixture with the basic Amberlyst A-21 ion-exchange resin. This procedure is suitable for the parallel deprotection of N-Boc amines.
authors.affiliation: School of Chemistry, University of Southampton, Southampton, SO17 1BJ, United Kingdom.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Srinivasan
authors.forename: Alexander
authors.initials: A
authors.lastname: Yurek-George
authors.forename: A
authors.initials: A
authors.lastname: Ganesan
mesh_terms: D000588:Amines / Q000737:chemistry*; D005563:Formic Acid Esters / Q000737:chemistry*; D007475:Ion Exchange Resins / Q000737:chemistry*; D013997:Time Factors; D014269:Trifluoroacetic Acid / Q000737:chemistry*
chemical_list: D000588:Amines; D005563:Formic Acid Esters; D007475:Ion Exchange Resins; C000345:t-butyloxycarbonyl group; D014269:Trifluoroacetic Acid