Relation between peripheral vascular endothelial function and coronary flow reserve in patients with chest pain and normal coronary angiogram.
To evaluate the relation between peripheral vascular endothelial function and coronary flow reserve (CFR), we assessed flow mediated dilation (FMD) of brachial artery and the intima-media thickness (IMT) of the carotid artery in 32 subjects (mean age 58+/-9 years, M/F=9:23 ) with chest pain and normal coronary angiogram. The subjects were divided into 2 groups according to CFR >or=2.1 or <2.1 measured with transthoracic echocardiography in distal left anterior descending coronary artery. We found % FMD was decreased in the group with CFR <2.1 than those of CFR >or=2.1 and CFR was correlated with peripheral FMD. However, IMT was not different between two groups. These results suggest that microvascular dysfunction is primarily related to endothelial dysfunction rather than advanced atherosclerosis and because it is a generalized process that involves the whole arteries, the measurement of brachial FMD can be a useful diagnostic tool to evaluate microvascular dysfunction in patients with chest pain and normal coronary angiogram.
Park
Chul-Soo
CS
Youn
Ho-Joong
HJ
Kim
Ji-Hoon
JH
Cho
Eun-Joo
EJ
Jung
Hae-Ok
HO
Jeon
Hui-Kyung
HK
Lee
Jong-Min
JM
Ihm
Sang-Hyun
SH
Oh
Yong-Seog
YS
Chung
Wook-Sung
WS
Kim
Jae-Hyung
JH
Choi
Kyu-Bo
KB
Hong
Soon-Jo
SJ
D000368:Aged; D002637:Chest Pain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D017023:Coronary Angiography; D003326:Coronary Circulation; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged