Effects of preparations modifying Th1/Th2 ratio on the incidence of clinical variants of chronic graft-versus-host reaction.
Induction of chronic graft-versus-host reaction in a semiallogenic DBA/2- (DBA/2xC57Bl/6) F1 system leads to the development of Th1- or Th2-dependent immunopathologies. Modification of the Th1/Th2 ratio during induction with preparations acting on the immune system cells via different mechanisms and shifting the Th1/Th2 balance towards Th2 (bisphenol A, pentoxifylline, muramyl dipeptide) increases the incidence of Th2-dependent autoimmune lupus-like glomerulonephritis.
Kudaeva
O T
OT
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. olga_kudaeva@mail.ru
Goiman
E V
EV
Lykov
A P
AP
Kolesnikova
O P
OP
Kozlov
V A
VA
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology; D000818:Animals; D019867:Anti-Glomerular Basement Membrane Disease / Q000209:etiology / Q000276:immunology; D001559:Benzhydryl Compounds; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology; D006087:Graft vs Host Reaction / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010431:Pentoxifylline / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D011507:Proteinuria / Q000139:chemically induced; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D000098826:Bisphenol A Compounds
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D001559:Benzhydryl Compounds; D010431:Pentoxifylline; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds