New fatty acid derivatives from Homaxinella sp., a marine sponge.
Fractionation of the MeOH extract of Homaxinella sp., a marine sponge, led to the isolation of a sodium salt of a new brominated FA (1), two new MG (2 and 4), and a new lysoPC (6). The geometry of the double bonds in 1 and 2 was defined by comparison of the NMR chemical shifts of the allylic carbons, nuclear Overhauser effect spectroscopy correlations of the allylic protons, and coupling constants of the vinylic protons with those reported. Evidence mainly from NMR and MS analyses established the planar structures of the compounds. Compounds 1, 2, 4, and 6 were evaluated for cytotoxicity against a panel of five human solid tumor cell lines. Only compound 1 showed moderate activity.
Mansoor
Tayyab A
TA
College of Pharmacy, Pusan National University, Busan, Korea.
Bae
Bok Hee
BH
Hong
Jongki
J
Lee
Chong O
CO
Im
Kwang Sik
KS
Jung
Jee H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001966:Bromine / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008244:Lysophosphatidylcholines / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D050178:Monoglycerides / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005227:Fatty Acids; D008244:Lysophosphatidylcholines; D050178:Monoglycerides; C508273:homaxicholine A; C508271:homaxinolin A; C508272:homaxinolin B; D001966:Bromine