[New antivirals for herpesviruses].
The long-term treatment of herpesvirus infections with current antivirals leads to the development of drug-resistant viruses. Because currently available antivirals finally target the viral DNA polymerase, mutant resistant to one drug often shows cross-resistance to other drugs. This evidence highlights the need for the development of new antivirals that have the different viral targets. Recently, high-through-put screening of large compound collections for inhibiting specific viral enzymes, or in vitro cell culture assay, has identified several new antivirals. These include the inhibitors of helicase/primase complex, terminase complex, portal protein and UL97 protein kinase. This review will focus on these new compounds that directly inhibit viral replication.
Eizuru
Yoshito
Y
Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan. ccvdgan@m.kufm.kagoshima-u.ac.jp
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D004265:DNA Helicases / Q000037:antagonists & inhibitors; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D024882:Drug Resistance, Viral; D004706:Endodeoxyribonucleases / Q000037:antagonists & inhibitors; D006564:Herpesviridae / Q000187:drug effects / Q000201:enzymology; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000627:therapeutic use; D019384:Nucleic Acid Synthesis Inhibitors; D012263:Ribonucleosides / Q000494:pharmacology / Q000627:therapeutic use; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives
D000998:Antiviral Agents; D001562:Benzimidazoles; D004265:DNA Helicases; D004706:Endodeoxyribonucleases; D047908:Intracellular Signaling Peptides and Proteins; D019384:Nucleic Acid Synthesis Inhibitors; D012263:Ribonucleosides; C015482:protein kinase modulator; C030894:terminase; C400401:maribavir; D004004:Dichlororibofuranosylbenzimidazole