[Breast adenocarcinoma: critical analysis of sentinel lymph node histopathological results of 542 procedures].
Between February 2001 and March 2003, 542 sentinel lymph node procedures were performed for localised breast carcinoma (T0-T1, N0, M0) without any previous treatment. Frozen sections were performed in 515 cases and they did not reveal metastases in 446 cases. Fifty-two micrometastases < 2 mm and 18 macrometastases were reported by definitive histopathological exam. Axillary clearance was performed in 50/70 patients (38 with micrometastases and 12 for macrometastases). Modalities of histopathological procedure are discussed and particularly number and interval of serial slides with or without immunochemistry ; 81.8% (36/44) of micrometastases were detected on the two first serial sections. Decisional value of axillary clearance performed in case of micrometastases is also evaluated.
Baranzelli
Marie-Christine
MC
Département d'anatomie pathologique, Centre Oscar-Lambret, 3, rue Combemale, BP 307, 59020 Lille Cedex. mc-baranzelli@o-lambret.fr
Giard
Sylvia
S
Cabaret
Véronique
V
Chauvet
Marie-Pierre
MP
Robin
Yves-Marie
YM
Vilain
Marie-Odile
MO
Carpentier
Philippe
P
Belkacémi
Yazid
Y
Bonneterre
Jacques
J
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005188:False Negative Reactions; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000473:pathology; D009367:Neoplasm Staging; D021701:Sentinel Lymph Node Biopsy / Q000706:statistics & numerical data; D013194:Staining and Labeling