(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population.
Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P < 10(-4)). The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P < 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.
Ballon
N
N
Department of Psychiatry, University Hospital of Fort de France, Fort de France, Martinique, French West Indies. ballon@informatique2000.fr
Leroy
S
S
Roy
C
C
Bourdel
M C
MC
Charles-Nicolas
A
A
Krebs
M O
MO
Poirier
M F
MF
D000328:Adult; D000818:Animals; D044383:Black People / Q000208:ethnology; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D019970:Cocaine-Related Disorders / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D004247:DNA / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008395:Martinique / Q000453:epidemiology; D009479:Neuropeptides / Q000235:genetics*; D011110:Polymorphism, Genetic; D000091363:Protocadherins; D011956:Receptors, Cell Surface / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics*
D015816:Cell Adhesion Molecules, Neuronal; D009479:Neuropeptides; C484820:PCDHA4 protein, human; D000091363:Protocadherins; D011956:Receptors, Cell Surface; D004247:DNA