Brain imaging findings in neonatal hypoglycemia: case report and review of 23 cases.
A hypoglycemic infant with secondary occipital brain injury defined by serial computed tomography and magnetic resonance imaging is described. An additional 22 similar cases were previously published in the English language literature. A total of 23 cases (including the present case) were reviewed. Abnormal brain imaging findings are associated with profound hypoglycemia and show involvement of the occipital lobes in 82% of affected newborns. Half of these infants had visual impairment, and their median and range of plasma glucose values, and postnatal age when hypoglycemia was first detected, were 7 mg/dL (range, 2-26 mg/dL) and 48 hours (range, 1-72 hours), respectively.
Alkalay
Arie L
AL
Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA.
Flores-Sarnat
Laura
L
Sarnat
Harvey B
HB
Moser
Franklin G
FG
Simmons
Charles F
CF
D001929:Brain Edema / Q000209:etiology*; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D007003:Hypoglycemia / Q000150:complications* / Q000188:drug therapy; D007231:Infant, Newborn; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology*; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D011877:Radionuclide Imaging; D012640:Seizures / Q000209:etiology
D005947:Glucose