Temperature-responsive cross-linked poly(epsilon-caprolactone) membrane that functions near body temperature.
The objective of this study is to develop a sensitive temperature-responsive material that would function near body temperature. To achieve this purpose, we compounded 2-branched and 4-branched poly(epsilon-caprolactone) macromonomers to modulate the transition temperatures of the resulting cross-linked materials. The temperature-responsive properties were studied using differential scanning calorimetry and X-ray diffraction measurements. As a result, the mixing ratios of each macromonomer or the total macromonomer concentrations were very dominant in modulating the transition temperatures. The materials could successfully control the permeation of the model drug, prednisolone, near body temperature.
Uto
Koichiro
K
Department of Nanostructure and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan.
Yamamoto
Kazuya
K
Department of Nanostructure and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan.
Hirase
Shohei
S
Department of Nanostructure and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan.
Aoyagi
Takao
T
Department of Nanostructure and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan; PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, Japan. Electronic address: aoyagi@eng.kagoshima-u.ac.jp.
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003432:Cross-Linking Reagents; D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D010539:Permeability; D011091:Polyesters / Q000737:chemistry*; D011239:Prednisolone / Q000008:administration & dosage / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D013696:Temperature
D000893:Anti-Inflammatory Agents; D003432:Cross-Linking Reagents; D008567:Membranes, Artificial; D011091:Polyesters; D011409:Propylene Glycols; C016240:polycaprolactone; D011239:Prednisolone; C008783:pentaerythritol