title: Plasma values of oxidants and antioxidants in acute brain hemorrhage: role of free radicals in the development of brain injury.
abstract: The levels of oxidants xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA) and of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione reductase (GRD) were determined in plasma within 24 h after onset of hemorrhagic stroke in 17 patients (9 men and 8 women, aged 60.7+/-11.5 yr) and in 20 healthy controls (12 men and 8 women, aged 62.5+/-8.3 yr). Compared to controls, the plasma SOD and total superoxide scavenger activities (TSSA) were significantly lower and the NO levels were significantly higher among the stroke patients. XO showed a slight, nonsignificant increase in the patients, but the levels of MDA, NSSA, GRD, and GSH-Px did not show any significant differences between the two groups. The hemorrhage volume was negatively correlated with the initial score of the Glasgow Coma Scale and a positive correlation with lethal outcome, but it did not correlate significantly with any of the measured parameters. The results suggest that free radicals might play a role in the development of brain injury following brain hemorrhage.
authors.affiliation: Department of Neurology, Medical Faculty, Ataturk University, Erzurum, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Aygul
authors.forename: Berna
authors.initials: B
authors.lastname: Demircan
authors.forename: Fuat
authors.initials: F
authors.lastname: Erdem
authors.forename: Hizir
authors.initials: H
authors.lastname: Ulvi
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yildirim
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirbas
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D002543:Cerebral Hemorrhage / Q000097:blood*; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D005609:Free Radicals / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D016877:Oxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D005980:Glutathione Reductase