Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer.
Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.
Tseng
Ya-Shih
YS
College of Medicine, Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, ROC.
Tzeng
Ching-Cherng
CC
Huang
Chi-Ying F
CY
Chen
Ping-Hong
PH
Chiu
Allen Wen-Hsiang
AW
Hsu
Pei-Yin
PY
Huang
Guan-Cheng
GC
Wang
Yu-Chun
YC
Liu
Hsiao-Sheng
HS
D001151:Arsenic / Q000633:toxicity; D064127:Aurora Kinases; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D003062:Codon; D019353:Endemic Diseases; D011905:Genes, ras; D006801:Humans; D009154:Mutation; D016491:Peripheral Vascular Diseases / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics
D003062:Codon; D012333:RNA, Messenger; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D001151:Arsenic