title: Bioactive tetrahydrofuran lignans from Peperomia dindygulensis.
abstract: Five new tetrahydrofuran lignans (1-5), accompanied by four known compounds, were isolated from the ethyl acetate extract of Peperomia dindygulensis. Structures were elucidated mainly using 1D NMR, 2D NMR, and mass spectroscopic studies. The relative configurations of 1-5 were determined by NOE correlations. Several of the compounds showed weak growth inhibitory activity against three cell lines (WI-38, VA-13, and HepG2). Compound 5 exhibited stronger MDR (multidrug resistance) reversal activity than verapamil at 2.5 microg/mL in a cellular calcein accumulation assay. Compounds 4 and 5 showed weak inhibitory activity against induction of the intercellular adhesion molecule-1 (ICAM-1) in anti-inflammatory activity experiments.
authors.affiliation: Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Niigata 950-2181, Japan.
authors.forename: Jian-lin
authors.initials: JL
authors.lastname: Wu
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Sakai
authors.forename: Saori
authors.initials: S
authors.lastname: Kakuta
authors.forename: Wanxia
authors.initials: W
authors.lastname: Tang
authors.forename: Seiko
authors.initials: S
authors.lastname: Oka
authors.forename: Miwa
authors.initials: M
authors.lastname: Kiuchi
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ogura
authors.forename: Takao
authors.initials: T
authors.lastname: Kataoka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tomida
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuruo
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ando
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D036941:Peperomia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D018799:Intercellular Adhesion Molecule-1; C018674:tetrahydrofuran