title: Acylation of carbohydrates over Al2O3: preparation of partially and fully acylated carbohydrate derivatives and acetylated glycosyl chlorides.
abstract: Selective and per-O-acylation of carbohydrate derivatives using acyl chlorides and Al2O3, a solid support reagent, is reported. This protocol does not require the addition of any base or activator. This methodology has been further extended to the selective acylation of carbohydrate diols and the one-pot preparation of acetylated glycosyl chlorides direct from free reducing sugars. The yields obtained in most of the cases are excellent.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, UP, India.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Tiwari
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
mesh_terms: D000215:Acylation; D000537:Aluminum Oxide / Q000737:chemistry*; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry*; D002712:Chlorides / Q000138:chemical synthesis* / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D002241:Carbohydrates; D002712:Chlorides; D006027:Glycosides; D000537:Aluminum Oxide