[Similarity of immunological mechanisms responsible for immunotolerance in healthy subjects and mechanisms induced by specific immunotherapy].
The immonomodulatory mechanisms responsible for allergens tolerance in healthy subjects were described on the basis of the newest medical literature, including own papers and experience. It was detected that the same immunological mechanisms are built by specific immunotherapy. IL-10 and TGF-beta cooperate in the regulatory T-cell response to aeroallergens, food allergens and allergens of bee and yellow jacket venoms in healthy subjects as well as during specific immunotherapy making the tolerance to these allergens. The actual progress in improvement of specific immunotherapy methods is described.
Gołebiowska-Wawrzyniak
Maria
M
Zakład Immunologii Klinicznej Instytutu Matki i Dziecka, Warszawie. immunolog@imid.med.pl
Markiewicz
Katarzyna
K
Wawrzyniak
Zbigniew M
ZM
Siwińska-Gołebiowska
Henryka
H
D000485:Allergens / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016753:Interleukin-10 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D000485:Allergens; D016212:Transforming Growth Factor beta; D016753:Interleukin-10