Synthesis of 6-[2-(benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acid and inhibitory activity on beta-amyloid aggregation.
6-[2-(benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acids were designed and synthesized as beta-amyloid (Abeta) fibril assembly inhibitors. Their inhibitory activity on Abeta, aggregation was evaluated by thioflavin T assay although their activities were insignificant.
Lee
Sun Mi
SM
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
Jeon
Raok
R
D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000187:drug effects*; D052160:Benzothiazoles; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009454:Neurofibrils / Q000737:chemistry / Q000187:drug effects; D012997:Solvents; D013050:Spectrometry, Fluorescence; D013844:Thiazoles / Q000737:chemistry
D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D001583:Benzoxazoles; D007202:Indicators and Reagents; D007211:Indoles; D012997:Solvents; D013844:Thiazoles; C009462:thioflavin T