title: [An outpatient with unresectable pancreatic cancer treated with gemcitabine showing prolonged NC (22 months)].
abstract: A 76-year-old man developed jaundice and was hospitalized in January 2002. A 3 cm tumor was found in the head of the pancreas by abdominal CT, and the patient underwent laparotomy. The tumor was histologically diagnosed as a well-differentiated adenocarcinoma, and showed extensive invasion to the portal vein (T4NXM 0 Stage IV a). Incisional biopsy and hepaticojejunostomy were performed. On the basis of a drug sensitivity test, chemotherapy with 800 mg/m2/week gemcitabine was administered. The patient showed prolonged NC without any symptoms for 22 months, although the CEA and DUPAN-2 levels gradually increased during this time and massive ascites were detected in a routine abdominal CT at 22 months postsurgery. The patient died after 25 months of chemotherapy. Here we report a case of unresectable pancreatic cancer treated with gemcitabine on the basis of a drug sensitivity test.
authors.affiliation: Dept. of Surgery, Jichi Medical School.
authors.forename: Masaru
authors.initials: M
authors.lastname: Koizumi
authors.forename: Naohiro
authors.initials: N
authors.lastname: Sata
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Shimura
authors.forename: Munetoshi
authors.initials: M
authors.lastname: Tsukahara
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshizawa
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kurihara
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hyodo
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Hideo
authors.initials: H
authors.lastname: Nagai
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000553:Ambulatory Care; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine