Total synthesis of aspercyclide C.
The first total synthesis of (+)-aspercyclide C (1) is reported using a kinetically controlled RCM reaction to form the 11-membered, unsaturated lactone ring of this bioactive diaryl ether macrolide.
Fürstner
Alois
A
Max-Planck-Institut für Kohlenforschung, D-45470, Mülheim/Ruhr, Germany. fuerstner@mpi-muelheim.mpg.de
Müller
Christoph
C
D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D007783:Lactones; D047028:Macrocyclic Compounds; C519042:aspercyclide C