title: Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
abstract: A new series of 3-benzyl-2-substituted quinoxalines have been synthesized by means of microwave enhancement of nucleophilic substitution reaction involving the corresponding 2-chloroquinoxaline analogs and substituted amines or hydrazine. The synthesized compounds were evaluated for their monoamine oxidase A and B inhibitory activity by determination of their IC(50). All the newly synthesized compounds showed more selective inhibitory activity toward MAO-A than MAO-B. In addition, the acute toxicity of the synthesized compounds was determined. This work may be a fruitful matrix of the synthesis of a new series of novel MAO-A inhibitors with good safety margins.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Alexandria, Alexandria 21521, Egypt.
authors.forename: Seham Y
authors.initials: SY
authors.lastname: Hassan
authors.forename: Sherine N
authors.initials: SN
authors.lastname: Khattab
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Bekhit
authors.forename: Adel
authors.initials: A
authors.lastname: Amer
mesh_terms: D000818:Animals; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D008995:Monoamine Oxidase / Q000737:chemistry* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D008996:Monoamine Oxidase Inhibitors; D011810:Quinoxalines; D008995:Monoamine Oxidase