[Effect of therapy with antibiotics on lipid metabolism and antioxidant reserve of patients with ischemic heart disease during Chlamydia pneumoniae infection].
Effect of therapy with azithromycin and doxycycline on lipid metabolism, processes of lipid peroxidation and state of antioxidant defense was studied in patients with ischemic heart disease with elevated titer of antibodies to Chlamydia Pneumonia. Therapy with azithromycin (500 mg/day for 2 months) was associated with lowering of antibody titer, moderate improvement of lipid spectrum, marked decrease of activity of lipid peroxidation and augmentation of blood plasma antioxidant reserve. There were no such changes in a group of doxycycline treated patients. This difference can be attributed to more pronounced antimicrobial activity of azithromycin against Chlamydophila Pneumonia and its intrinsic antioxidant properties.
Klochkov
V A
VA
Dovgalevskiĭ
P Ia
PIa
Umetskiĭ
K S
KS
Chalyk
N E
NE
Ansimova
O M
OM
Zigangirova
N A
NA
Petiaev
I
I
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000032:analysis; D000975:Antioxidants; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D023521:Chlamydophila Infections / Q000188:drug therapy* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D003627:Data Interpretation, Statistical; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications*; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D000975:Antioxidants; D017963:Azithromycin; D004318:Doxycycline