Surviving inside a macrophage: the many ways of Brucella.
Bacteria of the genus Brucella are intracellular pathogens capable of survival and replication within macrophages of mammalian hosts. Recent advances have shed light on virulence factors and host functions involved at various stages of the Brucella intracellular life cycle. This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication.
Celli
Jean
J
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton MT 59840, USA. jcelli@niaid.nih.gov
D000818:Animals; D002002:Brucella / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000382:microbiology; D052118:Lysosomal-Associated Membrane Protein 1 / Q000378:metabolism; D008247:Lysosomes / Q000502:physiology; D008264:Macrophages / Q000382:microbiology*; D008561:Membrane Fusion; D008954:Models, Biological; D014617:Vacuoles / Q000382:microbiology; D037521:Virulence Factors / Q000502:physiology; D047071:beta-Glucans / Q000378:metabolism
D052118:Lysosomal-Associated Membrane Protein 1; D037521:Virulence Factors; D047071:beta-Glucans; C033744:beta-1,2-glucan