title: Anti-inflammatory activity of Bacopa monniera in rodents.
abstract: The ethanol extract of Bacopa monniera (Scrophulariaceae) exhibited marked anti-inflammatory activity against carrageenan-induced paw edema in mice and rats, an acute inflammatory model. To assess the possible mechanism of anti-inflammatory action against carrageenan, the ethanol extract was treated with chemical mediators (histamine, serotonin, bradykinin, prostaglandin E(2) and arachidonic acid)-induced edema in rats. The extract selectively inhibited prostaglandin E(2)-induced inflammation. Thus, it may be inferred that B. monniera possesses significant anti-inflammatory activity that may well be relevant for its effectiveness in the healing of various inflammatory conditions in traditional medicine.
authors.affiliation: Department of Pharmacology and Therapeutics, Frontier Medical College, Abbottabad, Pakistan. shabanachanna@hotmail.com
authors.forename: Shabana
authors.initials: S
authors.lastname: Channa
authors.forename: Ahsana
authors.initials: A
authors.lastname: Dar
authors.forename: Shazia
authors.initials: S
authors.lastname: Anjum
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yaqoob
authors.lastname: Atta-Ur-Rahman
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D034681:Bacopa; D004487:Edema / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts