Increase in activity during calorie restriction requires Sirt1.
Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
Chen
Danica
D
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Steele
Andrew D
AD
Lindquist
Susan
S
Guarente
Leonard
L
D000818:Animals; D031204:Caloric Restriction; D004435:Eating; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity; D009068:Movement; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics / Q000502:physiology*
C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D037761:Sirtuins