title: Resolution of hypertensive encephalopathy and scleroderma renal crisis with an angiotensin receptor blocker.
abstract: The use of an angiotensin II type-1 receptor blocker for scleroderma renal crisis is controversial. We describe a 46-year-old woman presenting with a seizure secondary to hypertensive encephalopathy as the initial manifestation of scleroderma renal crisis. She had complete resolution of end organ damage with use of an angiotensin II type-1 receptor blocker. There may be a role for angiotensin II type-1 receptor blockers in the setting of scleroderma renal crisis with central nervous system involvement.
authors.affiliation: Department of Neurology, University of California-San Francisco, San Francisco, California, USA.
authors.forename: Pam R
authors.initials: PR
authors.lastname: Rajendran
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Molitor
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D046589:CADASIL / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D019808:Losartan / Q000627:therapeutic use*; D017241:MELAS Syndrome / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D019808:Losartan