Approach to novel functional foods for stress control 5. Antioxidant activity profiles of antidepressant herbs and their active components.
Oxidative stress is frequently mentioned in relation to the neurodegenerative diseases. This study examined the effect of three herb extracts, Hypericum perforatum, Ginkgo biloba L. and Apocynum venetum L., and their components on lipid hydroperoxide-induced oxidative stress in PC-12 cells. Among them, the extract of Apocynum venetum and its components showed the remarkable inhibitory effect, indicating that this herb extract serves as a protective agent against lipid peroxidation-related oxidative stress in CNS. Oxidative stress may be associated with the progress of depression, as this extract has been proposed to be an effective antidepresant herb.
Shirai
Mutsuko
M
Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
Kawai
Yoshichika
Y
Yamanishi
Rintaro
R
Terao
Junji
J
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D030010:Apocynum / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005502:Food; D020441:Ginkgo biloba / Q000737:chemistry; D020902:Hypericum / Q000737:chemistry; D008041:Linoleic Acids / Q000494:pharmacology; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000494:pharmacology; D020932:Nerve Growth Factor / Q000494:pharmacology; D018384:Oxidative Stress; D016716:PC12 Cells; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013997:Time Factors
D000928:Antidepressive Agents; D000975:Antioxidants; D008041:Linoleic Acids; D008054:Lipid Peroxides; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C038649:13-hydroperoxy-9,11-octadecadienoic acid; C021304:hyperoside; D020932:Nerve Growth Factor; D011794:Quercetin