Serum 17-alpha-hydroxyprogesterone and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs with suspected hyperadrenocorticism.
OBJECTIVE
To assess serum 17-alpha-hydroxyprogesterone (17OHP) and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs being screened for hyperadrenocorticism.


METHODS
Prospective study.


METHODS
16 clinically normal dogs, 35 dogs with nonadrenal neoplasia, and 127 dogs with suspected hyperadrenocorticism.


METHODS
ACTH stimulation tests were performed in all dogs. Baseline serum cortisol and corticosterone concentrations were measured in the healthy dogs; baseline serum cortisol concentration and ACTH-stimulated cortisol, corticosterone, and 17OHP concentrations were measured in all dogs. Endogenous plasma ACTH concentration was also measured before administration of ACTH in dogs with neoplasia.


RESULTS
In 35 dogs with neoplasia, 31.4% had high serum 17OHP concentration and 22.9% had high serum corticosterone concentration. Of the 127 dogs with suspected hyperadrenocorticism, 59 (46.5%) had high ACTH-stimulated cortisol concentrations; of those, 42 of 59 (71.2%) and 32 of 53 (60.4%) had high serum 17OHP and corticosterone concentrations, respectively. Of dogs with serum cortisol concentration within reference range after ACTH administration, 9 of 68 (13.2%) and 7 of 67 (10.4%) had high serum 17OHP and corticosterone concentrations, respectively. In the dogs with neoplasia and dogs suspected of having hyperadrenocorticism, post-ACTH serum hormone concentrations were significantly correlated.


CONCLUSIONS
Serum concentrations of 17OHP or corticosterone after administration of ACTH may be high in dogs with nonadrenal neoplasia and no evidence of hyperadrenocorticism. Changes in serum 17OHP or corticosterone concentrations after administration of ACTH are proportionate with changes in cortisol concentration.
Behrend
Ellen N
EN
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA.
Kemppainen
Robert J
RJ
Boozer
A Lindsay
AL
Whitley
Elizabeth M
EM
Smith
Annette N
AN
Busch
K Ann
KA
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood*; D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D005260:Female; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone