title: Migraine and MTHFR C677T genotype in a population-based sample.
abstract: OBJECTIVE
  Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status.
  
  
  METHODS
  We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study.
  
  
  RESULTS
  Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine.
  
  
  CONCLUSIONS
  Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.
authors.affiliation: Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814-4799, USA. ascher@usuhs.mil
authors.forename: Ann I
authors.initials: AI
authors.lastname: Scher
authors.forename: Gisela M
authors.initials: GM
authors.lastname: Terwindt
authors.forename: W M Monique
authors.initials: WM
authors.lastname: Verschuren
authors.forename: Mark C
authors.initials: MC
authors.lastname: Kruit
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Blom
authors.forename: Hisanori
authors.initials: H
authors.lastname: Kowa
authors.forename: Rune R
authors.initials: RR
authors.lastname: Frants
authors.forename: Arn M J M
authors.initials: AM
authors.lastname: van den Maagdenberg
authors.forename: Mark
authors.initials: M
authors.lastname: van Buchem
authors.forename: Michel D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
mesh_terms: D000328:Adult; D000368:Aged; D019731:Carbon-Nitrogen Ligases / Q000235:genetics*; D018672:Community Health Planning; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000145:classification / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D006710:Homocysteine; D019731:Carbon-Nitrogen Ligases; C021557:5,10-methenyltetrahydrofolate synthetase