title: Atypical fibroxanthoma on a bald scalp.
abstract: We present the clinical, histopathological and immunohistochemical findings of an atypical fibroxanthoma (AFX) on the bald scalp of an 81-year-old French man who had worked at a private high school in Japan as a janitor for over 40 years. The patient had a history of basal cell carcinoma on the nape, and chronic solar radiation seemed to be a predisposing factor in the pathogenesis of this association. This case showed the typical clinical and histopathological characteristics of AFX, and the immunohistochemical results suggested differentiation of histiocytes and myofibroblasts. The AFX was completely resected, and the patient has not had tumor recurrence or metastasis for over four postoperative years. This case therefore provides further support to the theory that AFX displays a clinically benign course, even though it is essentially a malignant tumor histologically located in the dermis. Therefore, we must excise AFX completely with great care and perform regular physical examinations for several years after operation.
authors.affiliation: Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Nakai
authors.forename: Hideya
authors.initials: H
authors.lastname: Takenaka
authors.forename: Saburo
authors.initials: S
authors.lastname: Kishimoto
mesh_terms: D000369:Aged, 80 and over; D000505:Alopecia / Q000150:complications; D006258:Head and Neck Neoplasms / Q000150:complications / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D012535:Scalp; D012536:Scalp Dermatoses / Q000150:complications / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology