title: Voriconazole in the treatment of fungal osteomyelitis of the orbit in the immunocompromised host.
abstract: Scedosporium apiospermum is an uncommon cause of fungal infection in the orbit and sinus. Morbidity and mortality rates in immunocompromised patients are high. We review the first case of Scedosporium apiospermum orbito-sinus infection that was successfully treated with the new antifungal agent voriconazole. We highlight the efficacy of this drug, particularly in the treatment of osteomyelitis of the orbit and sinus, which may lead to an improvement in survival rates after Scedosporium infection.
authors.affiliation: Department of Ophthalmology, Mater Misecordiae Hospital, Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: O'Doherty
authors.forename: M
authors.initials: M
authors.lastname: Hannan
authors.forename: T
authors.initials: T
authors.lastname: Fulcher
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D008271:Mycetoma / Q000175:diagnosis / Q000188:drug therapy*; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use*; D021681:Scedosporium / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole