title: Genetic risk factors in primary paediatric versus adult headache: complexities and problematics.
abstract: Numerous candidate genes for migraine have been proposed on the basis of their possible functional role in its pathogenesis. Genetic polymorphisms have been evaluated in association studies, some of which have been suggested to be susceptibility markers for adult migraine. To date, however, none of the identified polymorphisms in adult migraine susceptibility have been investigated in children, raising the possibility that they may not be necessarily involved in paediatric migraine susceptibility. This paper reviews studies of the genetic basis of migraine and summarises our experience in genetic association studies in primary paediatric headache susceptibility.
authors.affiliation: Research and Innovation (R&I) Company, Padua, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Lisi
authors.forename: Greta
authors.initials: G
authors.lastname: Garbo
authors.forename: Flavia
authors.initials: F
authors.lastname: Miccichè
authors.forename: Anna
authors.initials: A
authors.lastname: Stecca
authors.forename: Salvatore
authors.initials: S
authors.lastname: Terrazzino
authors.forename: Malida
authors.initials: M
authors.lastname: Franzoi
authors.forename: Elisa
authors.initials: E
authors.lastname: Tripoli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Clementi
authors.forename: Alberta
authors.initials: A
authors.lastname: Leon
authors.forename: Pier Antonio
authors.initials: PA
authors.lastname: Battistella
mesh_terms: D000328:Adult; D017677:Age Distribution; D002648:Child; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D008881:Migraine Disorders / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors