A new fluorescent assay for enalapril maleate.
A new spectrofluorimetric method for the enalapril maleate monitoring was studied. Enalapril maleate was found to be highly photolabile. This drug was evaluated according to photodegradation assay at pH 2.5 and 6. Enalapril maleate was exposed to UVA-UVB radiations. Under these specific conditions was found as degradation product, the diketopiperazine. The modification of the fluorescent properties of enalapril maleate in solution after exposure UV-radiation and the degradation mechanisms were studied. The photodegradation was followed by the developed spectrofluorimetric assay.
de los A Oliva
María
M
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. mdoliva@unsl.edu.ar
Sombra
Lorena L
LL
Olsina
Roberto A
RA
Masi
Adriana N
AN
D000959:Antihypertensive Agents / Q000737:chemistry* / Q000528:radiation effects; D054659:Diketopiperazines; D004656:Enalapril / Q000737:chemistry* / Q000528:radiation effects; D007700:Kinetics; D010782:Photolysis; D010879:Piperazines / Q000032:analysis*; D011355:Prodrugs / Q000737:chemistry* / Q000528:radiation effects; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014466:Ultraviolet Rays
D000959:Antihypertensive Agents; D054659:Diketopiperazines; D010879:Piperazines; D011355:Prodrugs; D004656:Enalapril