title: Thrombotic and nonthrombotic hepatic artery complications in adults and children following primary liver transplantation with long-term follow-up in 1000 consecutive patients.
abstract: Arterial complications have a major impact on survival after liver transplantation (LTx). The aim of this study was to examine arterial complications in adults and children after LTx. A total of 1000 consecutive primary LTx patients [mean age 40.5 years: 600 males, 400 females, 834 adults; 166 children (age <18 years)] were studied. Forty-two patients (4.2%; 31 adults, 11 children) developed hepatic artery thrombosis (HAT). Thrombosis in children occurred significantly early (mean 5.4 days) compared with adults (mean 418.7 days, P = 0.0001). Nonthrombotic complications occurred in 30 patients (29 adults, one child). Overall, 13-year patient survival after HAT was 43.2% (72.7% children, 32.9% adults). For nonthrombotic complications, 54.3% of adults died and 69.4% grafts were lost. An overall incidence of 4.2% thrombotic and 3.2% nonthrombotic complications was observed. Rate of HAT was higher in children, but survival was better compared with adults.
authors.affiliation: Department of Surgery, Division of Transplantation, University of Rochester Medical Centre, Rochester, NY 14642, USA. ashok_jain@urmc.rochester.edu
authors.forename: Ashokkumar
authors.initials: A
authors.lastname: Jain
authors.forename: Guilherme
authors.initials: G
authors.lastname: Costa
authors.forename: Wallis
authors.initials: W
authors.lastname: Marsh
authors.forename: Paulo
authors.initials: P
authors.lastname: Fontes
authors.forename: Michael
authors.initials: M
authors.lastname: Devera
authors.forename: George
authors.initials: G
authors.lastname: Mazariegos
authors.forename: Jorge
authors.initials: J
authors.lastname: Reyes
authors.forename: Kusum
authors.initials: K
authors.lastname: Patel
authors.forename: Ravi
authors.initials: R
authors.lastname: Mohanka
authors.forename: Mary
authors.initials: M
authors.lastname: Gadomski
authors.forename: John
authors.initials: J
authors.lastname: Fung
authors.forename: Amadeo
authors.initials: A
authors.lastname: Marcos
mesh_terms: D000293:Adolescent; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000453:epidemiology*; D002648:Child; D005500:Follow-Up Studies; D006499:Hepatic Artery / Q000473:pathology*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000502:physiology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000145:classification*; D012189:Retrospective Studies; D013927:Thrombosis / Q000453:epidemiology*; D013997:Time Factors; D016896:Treatment Outcome