title: Feline cutaneous and visceral necrotizing panniculitis and steatitis associated with a pancreatic tumour.
abstract: The association of pancreatic disorders with fat necrosis in domestic animals is rare. This report concerns a case of cutaneous/subcutaneous necrotizing panniculitis and steatitis associated with a pancreatic adenocarcinoma in an 11-year-old male Siamese cat. Clinical investigation revealed variably sized nodules on the trunk, limbs and abdomen. Some of them were ulcerated; others showed a shiny yellow necrotic background featuring irregular sinus tracts. The cat was euthanized at the owner's request before a diagnosis could be made. At necropsy, abundant oily material resembling mustard replaced the subcutaneous tissue and small yellow nodules were disseminated in the omentum, mesentery and serosa of the abdomen. A multilobulated mass arising from the anterior pancreatic head was found along with liver and lymph node metastasis. Histopathology showed wide fistulous tracts draining necrotic fat from the subcutis toward the surface and multifocal areas of necrotic adipocytes replacing the panniculus. Duct-like structures and tubules lined by neoplastic epithelial cells were observed in the primary pancreatic tumour and in the metastatic sites. The aetiology of the fat necrosis was possibly the result of systemic release of lipolytic pancreatic enzymes.
authors.affiliation: Clinica Veterinaria Papiniano, via Papiniano 50, 20123 MI, Milan, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Fabbrini
authors.forename: Pascal
authors.initials: P
authors.lastname: Anfray
authors.forename: Paolo
authors.initials: P
authors.lastname: Viacava
authors.forename: Michela
authors.initials: M
authors.lastname: Gregori
authors.forename: Francesca
authors.initials: F
authors.lastname: Abramo
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000473:pathology; D002415:Cats; D017809:Fatal Outcome; D008297:Male; D009336:Necrosis / Q000662:veterinary; D010179:Pancreas / Q000201:enzymology / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D015434:Panniculitis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D013231:Steatitis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology