title: A phase I clinical trial evaluating imatinib mesylate (Gleevec) in tumor-bearing cats.
abstract: A phase I clinical trial evaluating the toxicity of orally-administered imatinib mesylate was performed in 9 tumor-bearing cats. Imatinib is a small molecule, tyrosine kinase inhibitor, which selectively blocks the function of overexpressed proteins associated with various malignancies. Cats included in the study had diagnoses of fibrosarcoma, squamous cell carcinoma, and mast cell tumor, and each cat was staged using CBC and serum biochemistry; urinalysis, thoracic radiographs, and abdominal ultrasonography were performed in some cats. Most cats were treated previously by surgery, radiation therapy, chemotherapy, or some combination of these treatments. None of the cats received any concurrent chemotherapy. Six cats were treated with imatinib mesylate at 1-2 mg/kg PO q24h. Dose escalations were made to 2, 4, and 10 mg/kg PO q24h in 5 cats. Two cats started therapy at 10 mg/kg PO q24h, and 1 cat started therapy at 15 mg/kg PO q24h; all 3 cats remained at these dosages. No signs of toxicity, as evaluated by CBC and serum biochemistry, were noted in 8 of the 9 cats, and minimal gastrointestinal toxicity was observed. Due to the low frequency of adverse effects, further evaluation of imatinib is ongoing at a dosage of 10 mg/kg PO q24h.
authors.affiliation: Veterinary Oncology and Hematology Center, 178 Connecticut Avenue, Norwalk, CT 06854, USA. jlachowicz@oncovet.com
authors.forename: Joshua L
authors.initials: JL
authors.lastname: Lachowicz
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Post
authors.forename: Edwin
authors.initials: E
authors.lastname: Brodsky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001549:Benzamides; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000662:veterinary; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy / Q000662:veterinary; D000068877:Imatinib Mesylate; D008297:Male; D012515:Mast-Cell Sarcoma / Q000188:drug therapy / Q000662:veterinary; D009369:Neoplasms / Q000188:drug therapy* / Q000662:veterinary*; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate