[Stem cells and regeneration of human myocardium].
A concept of impossibility of appearance of novel cardiomyocytes in the heart of adult men in exchange for those lost due to cardiovascular diseases had dominated medicine and biology for many long decades. However ability of human myocardium to regenerate was demonstrated during recent years in multiple studies. This dictated necessity to reconsider previously generally accepted concept. At present researchers and practicing physicians actively discuss possibility of the use of transplantation of bone marrow stem cells, proper cardiac stem cells, skeletal muscle myoblasts or precursors of endothelial cells in patients with myocardial infarction and heart failure in order to restore normal cardiac structure and function. Another potential method of restoration of the myocardium in patients with cardiovascular diseases is the use of cytokines which stimulate migration of stem cells into myocardium and their differentiation into cardiomyocytes.
Kazakov
A V
AV
Muller
P
P
Beltrami
A P
AP
Pfeiffer
P
P
Chizelli
D
D
Bem
M
M
D002454:Cell Differentiation / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000378:metabolism*