title: Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils.
abstract: The Helicobacter pylori-infected Mongolian gerbil (MG) has been established as an appropriate animal model for studies of stomach cancer development. However, there have hitherto been no data on the phenotypic classification of glandular stomach cancers in H. pylori-infected and non-infected MG. We therefore examined the phenotypes of 50 and six advanced glandular stomach cancers in H. pylori-infected and non-infected MG, respectively, as well as adjacent non-neoplastic mucosa, using several gastrointestinal epithelial phenotypic markers. The lesions were divided phenotypically into 21 gastric, 24 gastric-and-intestinal mixed, four intestinal and one null types, with 90.0% of the lesions harboring gastric elements and 56.0% demonstrating intestinal phenotypic expression in H. pylori-infected MG. All six lesions were classified as gastric type in non-infected MG. There was no clear correlation with the presence of intestinal metaplasia in surrounding mucosa. In conclusion, our data suggest that most advanced adenocarcinomas retain a gastric cellular phenotype in the glandular MG stomach. Thus, it might be proposed that intestinal metaplasia is a paracancerous phenomenon rather than a premalignant condition. H. pylori infection may trigger intestinalization of both stomach cancers and non-neoplastic mucosa.
authors.affiliation: Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Cao
authors.forename: Sosuke
authors.initials: S
authors.lastname: Kato
authors.forename: Michio
authors.initials: M
authors.lastname: Kaminishi
authors.forename: Masae
authors.initials: M
authors.lastname: Tatematsu
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002454:Cell Differentiation; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000502:physiology*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*; D008770:Methylnitrosourea / Q000494:pharmacology; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000139:chemically induced / Q000150:complications / Q000382:microbiology / Q000473:pathology; D010641:Phenotype; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000150:complications / Q000382:microbiology / Q000473:pathology*
chemical_list: D002273:Carcinogens; D008770:Methylnitrosourea