title: Long-Term Production of Ergot Peptides by Immobilized Claviceps purpurea in Semicontinuous and Continuous Culture.
abstract: The semicontinuous and continuous production of pharmaceutically useful ergot peptides with immobilized Claviceps purpurea could be demonstrated. A key aspect was the presence of high concentrations of CaCl(2) (96.9 mM) to give marked prolongation of the productive phase, and cultivation in a bubble column reactor became possible. Restriction of the phosphate supply avoided an otherwise problematic massive increase of outgrowing hyphae.
authors.affiliation: Institut für Mikrobiologie, Universität Münster, Corrensstrasse 3, D-4400 Münster, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Dierkes
authors.forename: M
authors.initials: M
authors.lastname: Lohmeyer
authors.forename: H J
authors.initials: HJ
authors.lastname: Rehm