[Idiopathic central precocious puberty in girls in Bahia, Brazil].
BACKGROUND
Although the therapeutic effects of GnRH analogues (GnRHa) in central precocious puberty (CPP) have been established, clinical aspects may vary according to racial groups.


OBJECTIVE
To describe the profile of 175 girls from Bahia, Brazil, treated with GnRHa for idiopathic CPP.


RESULTS
The mulatto racial group predominated in the sample. The chronological age at puberty was 6.3 +/- 0.1 years. At diagnosis, height was 2.2 +/- 0.1 SD and body mass index (BMI) was 1.5 +/- 0.1 SD (> 2 SD in 32%), this one, inversely associated with age at onset of puberty (R = -0.20, p = 0.008). At treatment, chronological and bone ages were 8.4 +/- 0.1 years and 10.3 +/- 0.1 years, respectively. At the end of treatment (n = 52) age, BMI and height were 10.6 +/- 0.1 years, 1.6 +/- 0.2 SD and 1.9 +/- 0.2 SD, respectively.


CONCLUSIONS
Clinical presentation and evolution were similar to other studies, independently of racial characteristics. In this sample, treatment with GnRHa was not associated to significant weight gain.
Aguiar
Ana Luísa
AL
Departamento de Pediatria, Faculdade de Medicina, Universidade Federal da Bahia, Centro de Diabetes e Endocrinologia, Salvador, BA.
Couto-Silva
Ana Cláudia
AC
Freitas
Isabel
I
Cruz
Thomaz
T
Rodrigues
Maíra
M
Adan
Luís Fernando
LF
D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006801:Humans; D011629:Puberty, Precocious / Q000188:drug therapy* / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome
D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone