[Design and synthesis of quinoxaline derivatives and their antitumor activities].
OBJECTIVE
To design and synthesize novel quinoxaline derivatives as antitumor agents.


METHODS
Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives.


RESULTS
The structures of the target molecules were characterized by elemental analysis, 1H NMR, MS, and IR.


CONCLUSIONS
At concentration of 1 x 10(-4) mol x L(-1), some of the derivatives showed equal antitumor activities to XK469.
Zhao
Cui-Hua
CH
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China.
Chen
Yi
Y
Ding
Jian
J
Duan
Wen-Hu
WH
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D011810:Quinoxalines