title: Two infants with life-threatening diffuse neonatal hemangiomatosis treated with cyclophosphamide.
abstract: Diffuse neonatal hemangiomatosis (DNH) is a rare, frequently fatal disorder characterized by multiple cutaneous and visceral hemangiomas. Complications include high-output cardiac failure, hemorrhage, hepatic failure, and consumption coagulopathy. We present two cases of neonates with DNH. We prescribed cyclophosphamide after failure of corticosteroids. Cyclophosphamide induced a fast regression of the lesions with no side effects in both infants. We were able to stop treatment after 3-4 courses of cyclophosphamide in both infants because of the excellent response. Cyclophosphamide seems to be a safe and effective treatment in patients suffering from life-threatening DNH unresponsive to corticosteroids.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Children's Hospital, University of Saarland, Homburg, Germany. kisgot@uniklinik-saarland.de
authors.forename: Sven
authors.initials: S
authors.lastname: Gottschling
authors.forename: G
authors.initials: G
authors.lastname: Schneider
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.forename: H
authors.initials: H
authors.lastname: Reinhard
authors.forename: D
authors.initials: D
authors.lastname: Dill-Mueller
authors.forename: N
authors.initials: N
authors.lastname: Graf
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000798:Angiomatosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005260:Female; D006331:Heart Diseases / Q000209:etiology; D006391:Hemangioma / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D011859:Radiography; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide