title: Cardiac sarcoidosis: an elusive diagnosis.
abstract: The diagnosis of sarcoidosis of the heart can be elusive, and is seldom established in life. We report the case of a 43-year-old man who underwent heart transplantation for presumed idiopathic dilated cardiomyopathy. Endomyocardial biopsy before transplantation showed only a mild infiltrate of lymphocytes. Histology of his explanted heart revealed extensive noncaseating granulomas and scarring, typical of sarcoidosis. A diagnosis of sarcoidosis had been made several years before by mediastinoscopic biopsy, after routine chest X-ray revealed mediastinal lymphadenopathy. Aside from the cardiac manifestations, the patient had no other symptoms of this disease. We discuss the inherent difficulties in the diagnosis of this rare but important condition, its varying presentations relating to the underlying pathology, as well as treatment options, including the role of transplantation.
authors.affiliation: Department of Histopathology, Lab Plus, Auckland Hospital, New Zealand.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Kingston
authors.forename: Peter N
authors.initials: PN
authors.lastname: Ruygrok
authors.forename: Graeme B
authors.initials: GB
authors.lastname: Taylor
authors.forename: Sue I
authors.initials: SI
authors.lastname: O'Malley
authors.forename: Helen C
authors.initials: HC
authors.lastname: Gibbs
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Oldfield