title: Antimicrobial resistance data on 16,756 Streptococcus pneumoniae isolates in 1999: A Pan-Regional Multicenter Surveillance Study in France.
abstract: The rising prevalence of antibiotic-resistant Streptococcus pneumoniae is a phenomenon observed to different degrees around the world. The present national surveillance study report analyzes a total of 16,756 strains of S. pneumoniae collected across France in 1999. The overall prevalence of S. pneumoniae with decreased susceptibility to penicillin was 44%, to amoxicillin 26%, and to cefotaxime 17%. The proportion of high-level resistant strains to penicillin (MIC > 1 mg/L), amoxicillin and cefotaxime (MIC > 2 mg/L) remained low: 12.3%, 1.8%, and 0.4% respectively. Prevalence of resistance to other antibiotics was high: 53% to erythromycin, 41.7% to cotrimoxazole, 31.8% to tetracycline, and 24.6% to chloramphenicol. Prevalence of penicillin-resistant S. pneumoniae varied according to subject age and specimen source. It was higher in children (52.7%) than in adults (39.8%) and higher in strains isolated from middle ear fluid (63.6%) than from blood cultures (41.8%) in children. S. pneumoniae resistant to other antibiotics were more common in children than in adults, although figures showed geographical variations. Comparison with a previous study realized in 1997 in the same regions confirms a rising trend in the prevalence of resistant bacteria. Therefore, we conclude that prevalence of antibiotic-resistant S. pneumoniae in 1999 continued to rise in France, although strains with high-level resistance to penicillin remained stable.
authors.affiliation: CH Meaux, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Demachy
authors.forename: Véronique
authors.initials: V
authors.lastname: Vernet-Garnier
authors.forename: Jeanne
authors.initials: J
authors.lastname: Cottin
authors.forename: Blandine
authors.initials: B
authors.lastname: Cattier
authors.forename: Hubert
authors.initials: H
authors.lastname: Chardon
authors.forename: Monique
authors.initials: M
authors.lastname: Chomarat
authors.forename: Philippe
authors.initials: P
authors.lastname: Dupont
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Fauchere
authors.forename: Thierry
authors.initials: T
authors.lastname: Fosse
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Laaberki
authors.forename: Geneviève
authors.initials: G
authors.lastname: Laurans
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Lemozy
authors.forename: Jeanne
authors.initials: J
authors.lastname: Maugein
authors.forename: Valérie
authors.initials: V
authors.lastname: Murbach
authors.forename: André
authors.initials: A
authors.lastname: Pechinot
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Romaszko
authors.forename: Micheline
authors.initials: M
authors.lastname: Roussel-Delvallez
authors.forename: Pierre-Henri
authors.initials: PH
authors.lastname: Thoreux
authors.forename: Jacques
authors.initials: J
authors.lastname: Vaucel
authors.forename: Michel
authors.initials: M
authors.lastname: Vergnaud
authors.forename: Michèle
authors.initials: M
authors.lastname: Weber
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Ploy
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D005602:France; D006801:Humans; D011159:Population Surveillance; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents