title: Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity.
abstract: Infections can trigger or exacerbate the course of Multiple Sclerosis, and both bacterial and viral agents have been implicated. These agents are recognized by host cells via pathogen-associated molecular patterns activating TLRs. We investigated the role that PAMPs play in the animal model Experimental Autoimmune Encephalomyelitis, and found various MyD88-dependent PAMPs can participate as the adjuvant to induce EAE. Studies with IRAK1-deficient mice suggest that signaling through TLRs is not required in the target organ to develop disease. This suggests that PAMPs play an important role in priming of autoreactive T cells in EAE and potentially MS.
authors.affiliation: Department of Neurology, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX 75390, USA.
authors.forename: Baranda S
authors.initials: BS
authors.lastname: Hansen
authors.forename: Rehana Z
authors.initials: RZ
authors.lastname: Hussain
authors.forename: Amy E
authors.initials: AE
authors.lastname: Lovett-Racke
authors.forename: James A
authors.initials: JA
authors.lastname: Thomas
authors.forename: Michael K
authors.initials: MK
authors.lastname: Racke
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology*; D000818:Animals; D015551:Autoimmunity / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced*; D006023:Glycoproteins / Q000494:pharmacology; D053592:Interleukin-1 Receptor-Associated Kinases; D047908:Intracellular Signaling Peptides and Proteins / Q000172:deficiency; D008198:Lymph Nodes / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D063308:Myelin-Oligodendrocyte Glycoprotein; D053594:Myeloid Differentiation Factor 88; D010446:Peptide Fragments / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency; D013154:Spleen / Q000473:pathology; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D051193:Toll-Like Receptors / Q000819:agonists*; D014316:Tritium / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000277:Adjuvants, Pharmaceutic; D016207:Cytokines; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; C507780:Myd88 protein, mouse; D063308:Myelin-Oligodendrocyte Glycoprotein; D053594:Myeloid Differentiation Factor 88; D010446:Peptide Fragments; D051193:Toll-Like Receptors; C445081:myelin oligodendrocyte glycoprotein (35-55); D014316:Tritium; D053592:Interleukin-1 Receptor-Associated Kinases; C507769:Irak1 protein, mouse; D017346:Protein Serine-Threonine Kinases; D013936:Thymidine