Beneficial effects of Zingiber officinale Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats.
Fructose supplementation produced cardinal features of Syndrome-X including significant elevations in seum cholesterol, triglyceride, glucose and insulin and also in body weight. While treatment with methanolic extract of dried rhizomes of Zingiber officinale produced a significant reduction in fructose induced elevation in lipid levels, bodyweight, hyperglycemia and hyperinsulinemia, treatment with ethyl acetate extract of Z officinale did not poduce any significant change in either of the last two parameters. However, it produced a significant reduction in elevated lipid levels and body weight The concentration of 6-gingerol was found to be higher in methanolic extract and less in ethyl acetate extract. The results suggest that the methanolic extract of Z officinale produces better effects as compared to ethyl acetate extract in fructose induced hyperlipidemia associated with insulin resistance. The extent of activity appears to be dependent on the concentration of 6-gingerol present in the extracts.
Kadnur
Sanjay V
SV
Department of Pharmacology L. M. College of Pharmacy, Navarangpura, Ahmedabad 380 009, India.
Goyal
Ramesh K
RK
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002396:Catechols; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy; D005233:Fatty Alcohols / Q000032:analysis; D005632:Fructose / Q000633:toxicity*; D020939:Zingiber officinale / Q000737:chemistry; D006946:Hyperinsulinism / Q000097:blood / Q000178:diet therapy*; D006949:Hyperlipidemias / Q000178:diet therapy*; D024821:Metabolic Syndrome / Q000178:diet therapy; D010936:Plant Extracts / Q000008:administration & dosage; D051381:Rats; D027343:Rhizome / Q000737:chemistry
D002396:Catechols; D005233:Fatty Alcohols; D010936:Plant Extracts; D005632:Fructose; C007845:gingerol