title: [Gastroesophageal reflux and obstructive sleep apnea syndrome].
abstract: BACKGROUND
  Patients with mild or moderate Sleep Apnea Syndrome (SAS) need wider therapeutic scope options according to their disease severity.
  
  
  OBJECTIVE
  To consider including proton pump inhibitors (PPI) to the therapeutical alternatives of these patients.
  
  
  METHODS
  A prospective study was designed, among patients with SAS. Nocturnal polysomnography and double channel pHmetry were performed simultaneously.
  
  
  RESULTS
  From the 18 patients included in this preliminary phase, in three (16.7%) nocturnal proximal ph monitoring was positive. These 3 patients were treated with PPI during at least 3 months with a very satisfactory outcome in two of them.
  
  
  CONCLUSIONS
  Treatment with PPI may be a useful therapeutical alternative in patients with mild to moderate SAS.
authors.affiliation: Servicio de Otorrinolaringología, Hospital General de Catalunya, San Cugat del Vallès, Barcelona. esteller@abaforum.es
authors.forename: E
authors.initials: E
authors.lastname: Esteller
authors.forename: I
authors.initials: I
authors.lastname: Modolell
authors.forename: F
authors.initials: F
authors.lastname: Segarra
authors.forename: E
authors.initials: E
authors.lastname: Matiño
authors.forename: A
authors.initials: A
authors.lastname: Enrique
authors.forename: J M
authors.initials: JM
authors.lastname: Ademà
authors.forename: E
authors.initials: E
authors.lastname: Estivill
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D001562:Benzimidazoles / Q000627:therapeutic use*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077402:Pantoprazole; D011446:Prospective Studies; D054328:Proton Pump Inhibitors; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D013454:Sulfoxides / Q000627:therapeutic use*
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D054328:Proton Pump Inhibitors; D013454:Sulfoxides; D000077402:Pantoprazole; D009853:Omeprazole