Striatal dopamine D2/D3 receptor availability in male smokers.
It has been reported that the activation of the nicotine receptor evokes central endogenous dopamine release. However, whether smoking affects striatal dopamine D(2)/D(3) availability over the long run has not been well established in vivo. Fifteen male smokers and their matching controls were recruited. Striatal dopamine D(2)/D(3) receptor availability was assessed by single photon emission computed tomography with [(123)]IBZM Iodo-benzaimide. There was no significant difference in striatal D(2)/D(3) receptor availability between smokers and controls.
Yang
Yen Kuang
YK
Department of Psychiatry, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, Tainan 704, Taiwan. ykyang@mail.ncku.edu.tw
Yao
Wei Jen
WJ
McEvoy
Joseph P
JP
Chu
Ching Lin
CL
Lee
I Hui
IH
Chen
Po See
PS
Yeh
Tzung Lieh
TL
Chiu
Nan Tsing
NT
D000328:Adult; D001549:Benzamides; D003287:Contrast Media; D003342:Corpus Striatum / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism*
D001549:Benzamides; D003287:Contrast Media; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide