[Nucleotide correspondence between protein-coding sequences of Helicobacter pylori 26695 and J99 strains].
Comparison of open-reading frames (ORFs) H. pylori 26695 and J99 strains has been revealed prevalence of nucleotide replacements as transitions (more than 3%) above transversions (less than 1%). Prevalence of nucleotide transitions is caused by high speed of C : G to T : A transitions in a coding strand of DNA (3.5-5.3%) and not coding strand (2.9-3.9%). The correspondence rate of transversion (A --> C, A --> T, C --> A, C --> G, G --> C, G --> T, T --> A and T --> G) did not exceed 0.84%. The highest correspondence frequency between C and T was detected in ACGT-ATGT (28.3%) - the site of methylation by active methyltransferase M.Hpy99XI in H. pylori 26695 and J99. Thus one can speculate that predominant transition taking place in H. pylori is mutation of C into T, which is realized through cytosine methylation-deamination mechanism.
Momynaliev
K T
KT
Rogov
S I
SI
Govorun
V M
VM
D001426:Bacterial Proteins / Q000235:genetics; D019175:DNA Methylation; D016680:Genome, Bacterial / Q000235:genetics*; D016480:Helicobacter pylori / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics*; D017354:Point Mutation; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000235:genetics; D013045:Species Specificity
D001426:Bacterial Proteins; C108842:DNA modification methylase HpyI; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)