Anti-hypertension effects of traditional Chinese medicine ju-ling-tang on renal hypertensive rats.
This research investigated the anti-hypertension effect of the traditional Chinese medicine (TCM) ju-ling-tang (JLT) on an animal model of hypertension induced by unilateral renal artery ligation. In the study of anti-hypertension effects, 60 minutes after oral administration with NG tube feeding of 240 mg/kg JLT, a significant decrease in blood pressure (p < 0.05) was observed and sustained till 120 minutes. In the group given 50 mg/kg alpha-methyldopa orally, the effect was obvious 90 minutes after medication (p < 0.01), and lasted until 240 minutes. In terms of organ pathology, a significant reduction in the extent of induced glomerular sclerosis was observed in rats given 240 mg/kg JLT compared with the control. From these results, we infer that JLT has a beneficial anti-hypertensive effect on renal hypertension.
Shih
Hung-Che
HC
Department of Pharmacology, Chung Shan Medical University, Taichung, Taiwan. shj525@csmu.edu.tw
Lee
Tzu-Hsin
TH
Chen
Shu-Chen
SC
Li
Chien-Ying
CY
Shibuya
Takeshi
T
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001706:Biopsy; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy; D006977:Hypertension, Renal / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D008750:Methyldopa; D009543:Nifedipine