Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A>G) and migraine.
Migraine without aura (MO) and migraine with aura (MA) are disorders involving multiple environmental and genetic factors. The A/G polymorphism located within exon 1 of the gene encoding the cytotoxic T lymphocyte antigen 4 (CTLA-4) is associated with several HLA-associated multifactorial diseases. The CTLA-4 family shows a negative control on T-cell proliferation and cytokine production (TNF-alpha and IL-10). In the present study we investigated the contribution of the candidate gene CTLA-4 in migraine pathophysiology. Included in the study were 96 MO and 39 MA migraine patients and 106 healthy individuals as control group. The results showed no statistical difference of allele frequencies between patient group and control group. These results would indicate no association between MA and MO migraine and CTLA-4 polymorphism, excluding any possible role of the CTLA-4 gene as a genetic factor determining susceptibility to migraine.
Lulli
Patrizia
P
Clinical Genetics, 2nd School of Medicine, Rome University La Sapienza, Sant'Andrea Hospital, Via di Grottarossa 1035, I-00189 Rome, Italy. patrizia.lulli@uniroma1.it
Trabace
Simonetta
S
Morellini
Marina
M
Cicciarelli
Germana
G
Coloprisco
Gabriella
G
Piane
Maria
M
de Filippis
Sergio
S
Santi
Pier Giorgio
PG
Avramakou
Olga
O
Ferlicca
Eliana
E
Martelletti
Paolo
P
D000328:Adult; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000235:genetics* / Q000276:immunology; D020326:Migraine without Aura / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human