title: Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.
abstract: A series of purine nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methylribofuranosyl moiety were synthesized and evaluated as potential inhibitors of the hepatitis C virus in vitro. Of the nucleosides that were synthesized, only those possessing a 2-amino group on the purine base reduced the levels of HCV RNA in a subgenomic replicon assay.
authors.affiliation: Pharmasset Inc., 1860 Montreal Road, Tucker, GA 30084, USA. j.clark@sri.org
authors.forename: Jeremy L
authors.initials: JL
authors.lastname: Clark
authors.forename: J Christian
authors.initials: JC
authors.lastname: Mason
authors.forename: Laurent
authors.initials: L
authors.lastname: Hollecker
authors.forename: Lieven J
authors.initials: LJ
authors.lastname: Stuyver
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Tharnish
authors.forename: Tamara R
authors.initials: TR
authors.lastname: McBrayer
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Otto
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Furman
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: Kyoichi A
authors.initials: KA
authors.lastname: Watanabe
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D015394:Molecular Structure; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D012367:RNA, Viral / Q000187:drug effects / Q000235:genetics; D012093:Replicon / Q000187:drug effects; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D012367:RNA, Viral