title: [Efficacy of prednisolone and rimexolone in HLA-B27 positive patients with acute anterior uveitis].
abstract: OBJECTIVE
  To compare the efficacy and safety of prednisolone acetate 1% vs. rimexolone 1% ophthalmic suspension in the treatment of acute anterior uveitis (AAU) in HLA-B27+ patients.
  
  
  METHODS
  Sixty-eight AAU HLA-B27+ patients were randomly selected for treatment with prednisolone acetate 1% or Rimexolone 1%. All patients showed mild to moderate anterior chamber inflammation. This was a prospective, randomized, double blind, clinical trial.
  
  
  RESULTS
  There was no statistically significant difference between both groups when anterior chamber cells were measured. In the rimexolonae group, flare diminished since the first week. In both groups the intraocular pressure (IOP) raised since the first week, the increase was highly significant in the rimexolone group. Final intraocular pressure was higher in the prednisolone group.
  
  
  CONCLUSIONS
  Rimexolone 1% is as effective as prednisolone acetate 1% in the treatment of mild to moderate AAU HLA-B27+. IOP increased in both groups, but this variation was not clinically significant.
authors.affiliation: Clínica de Enfermedades Inflamatorias Oculares, Hospital Dr Luis Sánchez Bulnes de la Asociación para Evitar la Ceguera en México, Coyoacán. agml@servidor.unam.mx
authors.forename: Lourdes
authors.initials: L
authors.lastname: Arellanes-García
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Padilla-Aguilar
authors.forename: Patricia
authors.initials: P
authors.lastname: Navarro-López
authors.forename: Cynthia
authors.initials: C
authors.lastname: Espinoza-Martínez
mesh_terms: D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D011245:Pregnadienes / Q000627:therapeutic use*; D011446:Prospective Studies; D014605:Uveitis / Q000097:blood / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D015796:HLA-B27 Antigen; D011245:Pregnadienes; D011239:Prednisolone; C013769:rimexolone