title: 16-MDCT coronary angiography versus invasive coronary angiography in acute chest pain syndrome: a blinded prospective study.
abstract: OBJECTIVE
  The purpose of our study was to prospectively evaluate the usefulness of CT coronary angiography versus invasive coronary angiography for the detection of clinically significant coronary artery disease in patients hospitalized for acute chest pain syndrome.
  
  
  METHODS
  Sixty-six consecutive patients (52 men and 14 women; average age, 57 +/- 11 [SD] years) who were hospitalized for acute chest pain syndrome underwent CT coronary angiography and invasive coronary angiography within an average time interval of 4 days. ECG-gated CT coronary angiography was performed with a 16-MDCT scanner (0.42-sec rotation time, 16 x 0.75 mm detector collimation). Beta-blockers were not administered routinely, and thus the average heart rate was 71 +/- 11 beats per minute. CT coronary angiographic images were evaluated concurrently by two radiologists, who were blinded to invasive coronary angiography results, for stenoses having a diameter of 50% or more, using a 15-segment classification, including all segments 2 mm or more in diameter. The consensus interpretation was compared with results of invasive coronary angiography.
  
  
  RESULTS
  CT coronary angiography was technically successful in 59 patients (89%). After exclusion of 20 (3.1%) of 649 coronary segments, which were classified as nonevaluable by CT coronary angiography, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CT coronary angiography for identifying significant coronary artery disease in the remaining 629 coronary segments were 80% (68/85), 89% (482/544), 52% (68/130), 97% (482/499), and 87% (550/629), respectively. The overall accuracy for the main vessels (left main, left anterior descending, left circumflex, and right coronary arteries) was 93%, 88%, 86%, and 86%, respectively.
  
  
  CONCLUSIONS
  CT coronary angiography using a 16-MDCT scanner enables accurate noninvasive detection of significant coronary artery disease in patients hospitalized for acute chest pain syndrome. Furthermore, relative high sensitivity and specificity of CT coronary angiography can be achieved without pharmacologic manipulation of patient heart rates.
authors.affiliation: Department of Diagnostic Imaging, Rambam Medical Center, Haifa, Israel. e_ghersin@rambam.health.gov.il
authors.forename: Eduard
authors.initials: E
authors.lastname: Ghersin
authors.forename: Diana
authors.initials: D
authors.lastname: Litmanovich
authors.forename: Robert
authors.initials: R
authors.lastname: Dragu
authors.forename: Shmuel
authors.initials: S
authors.lastname: Rispler
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lessick
authors.forename: Amos
authors.initials: A
authors.lastname: Ofer
authors.forename: Olga R
authors.initials: OR
authors.lastname: Brook
authors.forename: Luis
authors.initials: L
authors.lastname: Gruberg
authors.forename: Rafael
authors.initials: R
authors.lastname: Beyar
authors.forename: Ahuva
authors.initials: A
authors.lastname: Engel
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D002637:Chest Pain / Q000000981:diagnostic imaging*; D016009:Chi-Square Distribution; D003287:Contrast Media; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007472:Iohexol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide