Etiology of fungaemia and catheter colonisation in Argentinean paediatric patients.
Yeast strains obtained from blood cultures and catheters from intensive care units (ICU) and hospitalised oncology paediatrics were studied. Yeast were the first cause of catheter colonisation (51/627), and the third cause of bloodstream infection (44/6065). In catheter, the most frequent species were Candida albicans (34%), C. parapsilosis (27.7%) and C. tropicalis (15%). In blood, C. albicans (40.8%), C. parapsilosis (26.6%), C. tropicalis (15%). Malassezia furfur and Malassezia sympodialis were isolated from catheters from ICU patients. All isolates were susceptible to amphotericin B, 88.8% to itraconazole and 91.9% to fluconazole. Candida albicans and C. tropicalis strains resistant to fluconazole and itraconazol were detected. These results reveal a change in the predominant role of C. albicans as cause of candidemia in hospitalised children and the emergence of antifungal resistant species. These variations emphasise the importance of performing a permanent surveillance to observe and assess them.
Giusiano
Gustavo
G
Departamento Micología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Resistencia, Chile.
Mangiaterra
Magdalena
M
Saito
Viviana García
VG
Rojas
Florencia
F
Gómez
Verónica
V
Díaz
María Cristina
MC
D000293:Adolescent; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001118:Argentina / Q000453:epidemiology; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology; D016469:Fungemia / Q000453:epidemiology* / Q000382:microbiology; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D015278:Intensive Care Units, Pediatric; D017964:Itraconazole / Q000494:pharmacology; D008290:Malassezia / Q000187:drug effects / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole