title: Male/female differences in indomethacin effects in preterm infants.
abstract: To test whether indomethacin prophylaxis has sex-mediated effects on severe intraventricular hemorrhage (grade III and IV) and on long-term outcomes in extremely-low-birth-weight infants. A secondary analysis was performed in the entire "Trial of Indomethacin Prophylaxis in Preterms study" cohort. The results suggest a weak differential treatment effect of indomethacin by sex.
authors.affiliation: University of Toronto, Toronto, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Arne
authors.initials: A
authors.lastname: Ohlsson
authors.forename: Robin S
authors.initials: RS
authors.lastname: Roberts
authors.forename: Barbara
authors.initials: B
authors.lastname: Schmidt
authors.forename: Peter
authors.initials: P
authors.lastname: Davis
authors.forename: Diane
authors.initials: D
authors.lastname: Moddeman
authors.forename: Saroj
authors.initials: S
authors.lastname: Saigal
authors.forename: Alfonso
authors.initials: A
authors.lastname: Solimano
authors.forename: Michael
authors.initials: M
authors.lastname: Vincer
authors.forename: Linda
authors.initials: L
authors.lastname: Wright
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002552:Cerebral Ventricles; D002658:Developmental Disabilities / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D020300:Intracranial Hemorrhages / Q000517:prevention & control*; D008297:Male; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin