Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.
Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.
Tunbridge
Anne J
AJ
Division of Genomic Medicine, F-Floor, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom.
Stevanin
Tania M
TM
Lee
Margaret
M
Marriott
Helen M
HM
Moir
James W B
JW
Read
Robert C
RC
Dockrell
David H
DH
D017209:Apoptosis / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology*; D008585:Meningitis, Meningococcal / Q000378:metabolism / Q000473:pathology; D009345:Neisseria meningitidis / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D018272:Porins / Q000235:genetics / Q000378:metabolism; D020298:U937 Cells
D018272:Porins; C057699:porin protein, Neisseria; D009569:Nitric Oxide