You can't go home again: transcriptionally driven alteration of cell signaling by NGF.
Here we review findings indicating that neurotrophins such as NGF promote changes in gene transcription that in turn influence the ways that cells subsequently respond to trophic factors. As a result, initial responses of "naïve" cells to NGF and other trophic agents differ from those of cells with prior NGF exposure. We discuss specific examples based on reports in the literature as well as on data derived from a serial analysis of gene expression (SAGE) study of NGF-promoted transcriptional changes in PC12 pheochromocytoma cells.
Greene
Lloyd A
LA
Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. lag@columbia.edu
Angelastro
James M
JM
D048948:14-3-3 Proteins / Q000378:metabolism; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D051380:GRB2 Adaptor Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism*; D016716:PC12 Cells; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000378:metabolism; D051381:Rats; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic
D048948:14-3-3 Proteins; D000943:Antigens, Differentiation; D002147:Calmodulin; D002352:Carrier Proteins; D016207:Cytokines; D051380:GRB2 Adaptor Protein; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011971:Receptors, Immunologic; C501920:SIRPA protein, human; C066845:pleiotrophin; D020932:Nerve Growth Factor; D066246:ErbB Receptors; D020962:Heterotrimeric GTP-Binding Proteins