title: Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs.
abstract: The supersaturatable self-emulsifying drug delivery system (S-SEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of a surfactant and a water-soluble cellulosic polymer (or other polymers) to prevent precipitation of the drug by generating and maintaining a supersaturated state in vivo. The S-SEDDS formulations can result in enhanced oral absorption as compared with the related self-emulsifying drug delivery systems (SEDDS) formulation and the reduced surfactant levels may minimise gastrointestinal surfactant side effects.
authors.affiliation: PGRD, Pfizer, Inc., 301 Henrietta Street, Kalamazoo, MI 49007, USA. ping.gao@pfizer.com
authors.forename: Ping
authors.initials: P
authors.lastname: Gao
authors.forename: Walter
authors.initials: W
authors.lastname: Morozowich
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004655:Emulsions; D006801:Humans; D007408:Intestinal Absorption; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011108:Polymers; D012995:Solubility; D013501:Surface-Active Agents
chemical_list: D004655:Emulsions; D004364:Pharmaceutical Preparations; D011108:Polymers; D013501:Surface-Active Agents