Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation.
This lecture summarizes the chronology and rationale that led to the discovery of angiotensin-(1-7) as a hormone that, in its own right, opposes the vasoconstrictor and proliferative actions of angiotensin II. The work discussed here additionally analyzes the newest findings on angiotensin-converting enzyme 2, the angiotensin-converting enzyme homologue that efficiently hydrolyzes angiotensin II into angiotensin-(1-7). Both components of this system may significantly influence our future perspective of the role of the renin-angiotensin system, not just in terms of its role in the regulation of cardiovascular and renal function but, moreover, as regulators of a vast array of disease processes in which inflammation and immune mechanisms play a role.
Ferrario
Carlos M
CM
Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA. cferrari@wfubmc.edu
D000803:Angiotensin I / Q000096:biosynthesis / Q000502:physiology*; D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D002268:Carboxypeptidases / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D010446:Peptide Fragments / Q000096:biosynthesis / Q000502:physiology*; D007703:Peptidyl-Dipeptidase A; D012083:Renin / Q000502:physiology
D010446:Peptide Fragments; D000803:Angiotensin I; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; D000085962:Angiotensin-Converting Enzyme 2; D012083:Renin; C118790:angiotensin I (1-7)