title: Is the platelet serotonin transporter different in venous vs. arterial blood?
abstract: The binding of labelled paroxetine to the serotonin transporter (SERT) of platelet membranes has been studied in both venous and mixed venous/arterial blood of the rat. In addition, we studied the inhibition of paroxetine binding to SERT by quipazine and N-methyl-quipazine (NMQ). The results indicate differences in affinity for the two test drugs, quipazine and NMQ, in venous vs. mixed venous/arterial blood. This suggests different post-translational modifications of SERT in platelets of arterial vs. venous blood.
authors.affiliation: Molecular Physiology and Bioimaging Institute, CNR, Sezione di Genova, Via De Toni 5, 16132, Genova, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Villa
authors.forename: Claudio
authors.initials: C
authors.lastname: Albano
authors.forename: Andrea
authors.initials: A
authors.lastname: Cappelli
authors.forename: Emilio
authors.initials: E
authors.lastname: Favale
authors.forename: Emilia
authors.initials: E
authors.lastname: Fugassa
authors.forename: Ezio
authors.initials: E
authors.lastname: Gerdoni
authors.forename: Simona
authors.initials: S
authors.lastname: Scarrone
authors.forename: Aroldo
authors.initials: A
authors.lastname: Cupello
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism*; D001769:Blood / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D011814:Quipazine / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D050486:Serotonin Plasma Membrane Transport Proteins / Q000097:blood* / Q000235:genetics; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000378:metabolism; D014680:Veins / Q000378:metabolism*
chemical_list: D017374:Paroxetine; D011814:Quipazine; D050486:Serotonin Plasma Membrane Transport Proteins; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors