Synthesis of a novel cyclic donor-acceptor conjugate for selective recognition of ATP.
[reaction and structures: see text] Novel cyclophane 1 was synthesized, and its interactions with phosphate, adenosine, AMP, ADP, and ATP have been investigated. With addition of ATP, significant decrease in absorbance of 1 was observed, whereas other guest molecules showed negligible effect. The complex between 1 and ATP was confirmed through cyclic voltammetry and 1H NMR. The uniqueness of the system is that it complexes selectively with ATP in a cavity and involves synergistic effects of both electrostatic and pi-pi stacking interactions.
Neelakandan
Prakash P
PP
Photosciences and Photonics Division, Regional Research Laboratory (CSIR), Trivandrum 695019, India.
Hariharan
Mahesh
M
Ramaiah
Danaboyina
D
D000227:Adenine Nucleotides / Q000737:chemistry; D000255:Adenosine Triphosphate / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D055672:Static Electricity
D000227:Adenine Nucleotides; D006576:Heterocyclic Compounds, 4 or More Rings; D000255:Adenosine Triphosphate