APC and chromosome instability in colorectal cancer.
Colon cancer is a common disease that can be sporadic or familial. An inactivated adenomatous polyposis coli (APC) suppressor gene is found in over 80% of colorectal tumors, this being an early alteration in the development of adenomatous polyps. APC function is not only critical for tumor initiation and progression, and chromosome instability (CIN) is another characteristic dependent at least partly on APC mutations.
Cabrera
C M
CM
Service of Pathology, Hospital Universitario Virgen de las Nieves, Granada, Spain. mcabrm@fundacionhvn.org
López-Nevot
M A
MA
D043171:Chromosomal Instability; D015179:Colorectal Neoplasms / Q000235:genetics*; D017491:Genes, APC; D006801:Humans