title: Expectation and knowledge of women undergoing first-trimester combined screening for Down syndrome in a Chinese population.
abstract: OBJECTIVE
  To study the preference of pregnant women regarding the time taken to report the results of first-trimester combined screening for Down syndrome and their knowledge about it.
  
  
  METHODS
  A questionnaire survey was conducted on a cohort of 325 pregnant participants who attended our first-trimester combined nuchal translucency and biochemical screening programme for fetal Down syndrome. This service was operated in a one-stop setting and the result of the screening test was available within 1 to 2 h after the collection of blood sample.
  
  
  RESULTS
  The majority of participants: (1) could recall the quoted detection rate correctly (96.6%); (2) understood that a negative test does not exclude Down syndrome (91.1%); (3) understood that a positive test does not equate to an affected fetus (91.0%), and (4) could decide on the need for further invasive tests on the basis of the screening test results (98.1%). Twenty-nine percent of participants considered that a one-stop setting was very important because any delay in releasing the results made a significant difference to them, while 48.9% considered it acceptable if the results were available on the same day. The percentage dropped dramatically to 6.3% (within 2 days), 6.7% (within 3 days), 5.7% (within 1 week), and 3.1% (more than 1 week).
  
  
  CONCLUSIONS
  The majority of the pregnant women in our test considered same day reporting of screening test results to be no different from a one-stop clinic. This would have important implications for the organisation and structuring of our service provision, since the operation of a one-stop clinic imposes significant stresses on the clinical staff involved.
authors.affiliation: Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR. danielchan@cuhk.edu.hk
authors.forename: Lin Wai
authors.initials: LW
authors.lastname: Chan
authors.forename: Mo Ching Macy
authors.initials: MC
authors.lastname: Chau
authors.forename: Tak Yeung
authors.initials: TY
authors.lastname: Leung
authors.forename: Tak Yuen
authors.initials: TY
authors.lastname: Fung
authors.forename: Tse Ngong
authors.initials: TN
authors.lastname: Leung
authors.forename: Tze Kin
authors.initials: TK
authors.lastname: Lau
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004314:Down Syndrome / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D019359:Knowledge; D008403:Mass Screening / Q000379:methods* / Q000523:psychology; D048208:Nuchal Translucency Measurement / Q000379:methods; D010353:Patient Education as Topic; D017060:Patient Satisfaction; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis / Q000379:methods / Q000523:psychology*; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A