[Aspects of biological activity of T and NK lymphocytes in children with adenoid hypertrophy and concomitant otitis media with effusion].
The aim of this study was to inquire whether it has got an influence on the number and activity of peripheral blood T and NK cells.


METHODS
The examined group consisted of 51 children with adenoid hypertrophy. The first group consisted of 17 children with only one episode of otitis media with effusion (ome). The second group consisted of 14 children with more than 4 episodes of ome and the third group consisted of 20 children with adenoid hypertrophy without ome. Evaluation of percentage of CD4+, CD8+ and NK subsets with co-expression of CD69, HLA-DR molecules in peripheral blood was performed by flow cytometry method. In examined groups with ome the decrease of CD4 number was compensated by increase of the number of NK and CD19 cells. In these groups the increase of CD69 and HLA-DR expression on the examined subsets was observed. The results suggest that in recurrent otitis media with effusion may be one of the factors causing T lymphocytes deficiency. Obtained results might be one of the criteria of using adenoidectomy.
Stasiak-Barmuta
Anna
A
Pracownia Cytometrii Przeptywowej SP DSK, Biatymstoku. barmuta@csk.pl
Stankiewicz
Wanda
W
Zielnik-Jurkiewicz
Beata
B
Rapiejko
Piotr
P
D000234:Adenoids / Q000473:pathology* / Q000503:physiopathology; D015703:Antigens, CD / Q000097:blood; D018941:Antigens, CD19 / Q000097:blood; D000945:Antigens, Differentiation, T-Lymphocyte / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D006984:Hypertrophy / Q000150:complications; D007694:Killer Cells, Natural / Q000378:metabolism*; D037181:Lectins, C-Type; D008297:Male; D010034:Otitis Media with Effusion / Q000209:etiology / Q000378:metabolism*; D012008:Recurrence; D013601:T-Lymphocytes / Q000378:metabolism*; D000099192:CD69 Antigens
D015703:Antigens, CD; D018941:Antigens, CD19; D000945:Antigens, Differentiation, T-Lymphocyte; D006684:HLA-DR Antigens; D037181:Lectins, C-Type; D000099192:CD69 Antigens