title: A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome.
abstract: Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushing's syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of suspected ectopic ACTH secretion, it is difficult to histologically or cytochemically confirm the diagnosis. We present a 63-year-old woman with a recurrent poorly differentiated squamous cell lung carcinoma with clinical and biochemical features consistent with ectopic Cushing's syndrome. Immunocytochemical staining confirmed the secretion of ACTH by tumour cells.
authors.affiliation: Sint Franciscus Gasthuis, Department of Respiratory Diseases, Rotterdam, The Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: Noorlander
authors.forename: J W
authors.initials: JW
authors.lastname: Elte
authors.forename: O C
authors.initials: OC
authors.lastname: Manintveld
authors.forename: K G
authors.initials: KG
authors.lastname: Tournoy
authors.forename: M M
authors.initials: MM
authors.lastname: Praet
authors.forename: J P
authors.initials: JP
authors.lastname: van Meerbeeck
authors.forename: J G
authors.initials: JG
authors.lastname: Aerts
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications*; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008875:Middle Aged
chemical_list: D000324:Adrenocorticotropic Hormone