title: Approach to novel functional foods for stress control 5. Antioxidant activity profiles of antidepressant herbs and their active components.
abstract: Oxidative stress is frequently mentioned in relation to the neurodegenerative diseases. This study examined the effect of three herb extracts, Hypericum perforatum, Ginkgo biloba L. and Apocynum venetum L., and their components on lipid hydroperoxide-induced oxidative stress in PC-12 cells. Among them, the extract of Apocynum venetum and its components showed the remarkable inhibitory effect, indicating that this herb extract serves as a protective agent against lipid peroxidation-related oxidative stress in CNS. Oxidative stress may be associated with the progress of depression, as this extract has been proposed to be an effective antidepresant herb.
authors.affiliation: Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Shirai
authors.forename: Yoshichika
authors.initials: Y
authors.lastname: Kawai
authors.forename: Rintaro
authors.initials: R
authors.lastname: Yamanishi
authors.forename: Junji
authors.initials: J
authors.lastname: Terao
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D030010:Apocynum / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005502:Food; D020441:Ginkgo biloba / Q000737:chemistry; D020902:Hypericum / Q000737:chemistry; D008041:Linoleic Acids / Q000494:pharmacology; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000494:pharmacology; D020932:Nerve Growth Factor / Q000494:pharmacology; D018384:Oxidative Stress; D016716:PC12 Cells; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D000975:Antioxidants; D008041:Linoleic Acids; D008054:Lipid Peroxides; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C038649:13-hydroperoxy-9,11-octadecadienoic acid; C021304:hyperoside; D020932:Nerve Growth Factor; D011794:Quercetin