title: Early decrease of the percent of HOMA beta-cell function is independently related to family history of diabetes in healthy young nonobese individuals.
abstract: OBJECTIVE
  To determine the relationship between family history of diabetes (FHD) and decrease in percent of HOMA beta-cell function (HOMA-beta%) index in healthy betanon-obese Mexican subjects.
  
  
  METHODS
  Forty-eight individuals (30 women and 18 men) with FHD were compared vs 48 control subjects (30 women and 18 men) in a cross-sectional study matched by age, sex, and Waist-to-Hip ratio. Pregnancy, obesity, being overweight, alcohol consumption, high blood pressure, and heavy physical activity were exclusion criteria. All the participants were required to have a Body Mass Index < 25 kg/m2 and serum fasting and 2-hours postload glucose levels lower than 6.1 mmol/l and 7.8 mmol/l, respectively. The reciprocal of serum fasting insulin concentrations (1/Ins0) (microU/ml) and HOMA-B% index were used as indicators of insulin sensitivity and beta-cell function.
  
  
  RESULTS
  Average age was of 19.4 +/- 3.6 vs 19.8 +/- 2.6, P = 0.66 for the subjects with and without FHD. HOMA-beta% index was significantly lower in the subjects with FHD (186.1 +/- 74.1 vs 252.7 +/- 149.5, P = 0.01). For similar levels of insulin sensitivity, subjects with FHD showed lower HOMA-beta% index than control subjects (P < 0.001). Multivariate regression analysis showed a strong and independent relationship between FHD and decrease of HOMA-beta% index (OR 2.6, CI95% 1.2-4.3, P = 0.01).
  
  
  CONCLUSIONS
  This study shows that normal-weight offspring of type 2 diabetes subjects exhibited a significant decrease of HOMA-beta% index suggesting that FHD exerts an independent early negative effect on beta-cell function.
authors.affiliation: Medical Research Unit in Clinical Epidemiology, General Hospital of the Mexican Institute of Social Security (MISS), Durango, Mexico. guerrero_romero@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Guerrero-Romero
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Morán
authors.forename: M
authors.initials: M
authors.lastname: González-Ortiz
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Abundis
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D049628:Body Size; D003920:Diabetes Mellitus / Q000235:genetics*; D005190:Family; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D008800:Mexico; D009765:Obesity / Q000503:physiopathology; D050177:Overweight; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin