Significantly reduced salivary nitric oxide synthesis in patients with Parkinson's disease.
In order to study concentration of nitric oxide (NO) in the saliva of patients with Parkinson's disease (PD), we measured the concentration of its stable metabolite nitrite (NO(2)-) in the saliva of these patients and healthy subjects. We analyzed saliva flow rate and salivary NO concentrations in 16 subjects with Parkinson's disease and in 16 healthy subjects. Concentration of nitrite was determined by colorimetric method using Griess reaction. Saliva flow rate was significantly lower in patients with Parkinson's disease (0.2+/-0.03 mL/min; X+/-SEM) than in healthy subjects. Salivary NO(2)-concentration was significantly lower (5.02+/-0.64) than in healthy individuals (22.39+/-1.24, p<0.0001).
Huskić
Jasminko
J
Institute of Physiology and Biochemistry, School of Medicine, University of Sarajevo, Cekalusa 90, 71000 Sarajevo, Bosnia and Herzegovina.
Paperniku
Alma
A
Husić
Azra
A
Alendar
Faruk
F
Mulabegović
Nedzad
N
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism* / Q000503:physiopathology*; D012463:Saliva / Q000378:metabolism*; D012472:Salivation / Q000502:physiology*; D012636:Secretory Rate
D009569:Nitric Oxide