title: Aggressive undifferentiated squamous cell carcinoma in an immunosuppressed patient after kidney transplantation.
abstract: A 56-year-old man developed a highly aggressive squamous cell carcinoma (SCC) on the upper back five years ago renal transplantation and subsequent immunosuppression. The tumor was excised using the three-dimensional micrographic technique; after the formation of granulation tissue, the wound was covered with a Meshgraft. His cyclosporine A dose was reduced from 2.5 to 2.0 mg/kg. The patient was counseled on sun avoidance and use of sunscreens, as well as placed on low-dose oral acitretin and imiquimod 5% cream to control actinic keratoses. He is followed every 3 months by a dermatologist and has shown no evidence of recurrence over 2 years.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Leipzig University, Germany. ufh@medizin.uni-leipzig.de
authors.forename: Uwe-Frithjof
authors.initials: UF
authors.lastname: Haustein
authors.forename: Uwe
authors.initials: U
authors.lastname: Paasch
mesh_terms: D017255:Acitretin / Q000008:administration & dosage / Q000627:therapeutic use; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000284:Administration, Oral; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control / Q000601:surgery; D003376:Counseling; D016572:Cyclosporine / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007642:Keratosis / Q000188:drug therapy / Q000517:prevention & control; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control / Q000601:surgery; D013473:Sunscreening Agents / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D007641:Keratolytic Agents; D009824:Ointments; D013473:Sunscreening Agents; D016572:Cyclosporine; D017255:Acitretin; D000077271:Imiquimod