title: A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder.
abstract: We tested and compared the use of two adjunctive hormonal agents, tamoxifen and medroxyprogesterone acetate (MPA), for the treatment of acute mania or hypomania. A total of 13 women with acute Bipolar Affective Disorder in the manic or hypomanic phase were recruited from a clinical population to participate in this 28-day, three-arm, double blind, placebo-controlled study. The women who received tamoxifen exhibited significant improvement in symptoms of mania from baseline to final assessment compared with the placebo group. The MPA group improved more than the placebo group. Further exploration of tamoxifen as a useful adjunct in the treatment of acute manic symptoms in women with Bipolar Affective Disorder is warranted.
authors.affiliation: Alfred Psychiatry Research Centre, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia. jayashri.kulkarni@med.monash.edu.au
authors.forename: Jayashri
authors.initials: J
authors.lastname: Kulkarni
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Garland
authors.forename: Antonietta
authors.initials: A
authors.lastname: Scaffidi
authors.forename: Barbara
authors.initials: B
authors.lastname: Headey
authors.forename: Robyn
authors.initials: R
authors.lastname: Anderson
authors.forename: Anthony
authors.initials: A
authors.lastname: de Castella
authors.forename: Paul
authors.initials: P
authors.lastname: Fitzgerald
authors.forename: Susan R
authors.initials: SR
authors.lastname: Davis
mesh_terms: D000208:Acute Disease; D000328:Adult; D000704:Analysis of Variance; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D004958:Estradiol / Q000097:blood; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D008875:Middle Aged; D010865:Pilot Projects; D045167:Progesterone Congeners / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric; D013629:Tamoxifen / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018692:Antimanic Agents; D004965:Estrogen Antagonists; D045167:Progesterone Congeners; D013629:Tamoxifen; D004958:Estradiol; D008525:Medroxyprogesterone