title: Patients with headache and functional dyspepsia present meal-induced hypersensitivity of the stomach.
abstract: Headache is a frequent feature of functional gastrointestinal disorders but there is no data on the responsible pathophysiological mechanism. The aim of this study was to verify whether alteration of post-prandial gastric tone or sensitivity might explain this association. Fourteen patients affected by functional dyspepsia (7 migraine without aura) and 7 healthy volunteers (HV) underwent gastric tone measurement in fasting condition and after the administration of a liquid meal by barostat. Gastric volume (GV) and accommodation were calculated as difference between mean post-prandial and mean fasting volume. Mean postprandial GV increase and fasting perception and discomfort threshold (DTh) were similar among the 3 groups. DTh after meal was lower in dyspeptic headache patients than in HV and dyspeptic without headache patients. Patients with migraine and functional dyspepsia may be characterised by meal-induced hypersensitivity of the stomach.
authors.affiliation: University Centre for Adaptive Disorders and Headache (UCADH), University of Pavia, IRCCS C. Mondino, Via Mondino 2, I-27100 Pavia, Italy. ennio.pucci@mondino.it
authors.forename: Ennio
authors.initials: E
authors.lastname: Pucci
authors.forename: Michele
authors.initials: M
authors.lastname: Di Stefano
authors.forename: Emanuela
authors.initials: E
authors.lastname: Miceli
authors.forename: Gino R
authors.initials: GR
authors.lastname: Corazza
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sandrini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nappi
mesh_terms: D000328:Adult; D004415:Dyspepsia / Q000150:complications* / Q000503:physiopathology*; D004435:Eating; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000150:complications*; D019518:Postprandial Period; D013270:Stomach / Q000503:physiopathology*