Male/female differences in indomethacin effects in preterm infants.
To test whether indomethacin prophylaxis has sex-mediated effects on severe intraventricular hemorrhage (grade III and IV) and on long-term outcomes in extremely-low-birth-weight infants. A secondary analysis was performed in the entire "Trial of Indomethacin Prophylaxis in Preterms study" cohort. The results suggest a weak differential treatment effect of indomethacin by sex.
Ohlsson
Arne
A
University of Toronto, Toronto, McMaster University, Hamilton, Ontario, Canada.
Roberts
Robin S
RS
Schmidt
Barbara
B
Davis
Peter
P
Moddeman
Diane
D
Saigal
Saroj
S
Solimano
Alfonso
A
Vincer
Michael
M
Wright
Linda
L
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002552:Cerebral Ventricles; D002658:Developmental Disabilities / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D020300:Intracranial Hemorrhages / Q000517:prevention & control*; D008297:Male; D012737:Sex Factors; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin