title: Whole-body MRI for staging patients with head and neck squamous cell carcinoma.
abstract: CONCLUSIONS
  Whole-body MRI is feasible for the tumor staging of patients with malignant head and neck tumors and appears to be a quick, reliable and proven alternative in general and for patients with contraindications to CT. This examination minimizes the logistical effort required compared to multimodality strategies. Its economic impact remains to be determined.
  
  
  OBJECTIVE
  To assess the performance of whole-body MRI for staging patients with squamous cell carcinoma of the head and neck region.
  
  
  METHODS
  This was a randomized, prospective clinical study. For tumor staging, 21 patients (mean age 56.7 years; range 43-80 years) with advanced malignant head and neck tumors underwent whole-body MRI in addition to routinely performed imaging investigations, including sonography, chest X-ray, CT of the head, neck and thorax and endoscopy. All investigations were accomplished within a period of 10+/-3 days in a random order. A randomized, blinded, consensus assessment of all the whole-body MRI examinations was performed by two radiologists. The localization and extent of the primary tumor and metastases were documented for whole-body MRI and compared to the standard of reference (all other imaging modalities as well as histology). Point estimates of the diagnostic accuracy of whole-body MRI were calculated.
  
  
  RESULTS
  In accordance with the standard of reference, the overall TNM category was correctly determined with whole-body MRI in all 21 patients. However, four patients were classified as having carcinoma of unknown primary, as the primary tumor was not found with any imaging modality. Two patients had mediastinal, pulmonary and hepatic metastases.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Essen, Essen, Germany.
authors.forename: Christoph U
authors.initials: CU
authors.lastname: Herborn
authors.forename: Claus
authors.initials: C
authors.lastname: Unkel
authors.forename: Florian M
authors.initials: FM
authors.lastname: Vogt
authors.forename: Sandra
authors.initials: S
authors.lastname: Massing
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Lauenstein
authors.forename: Andreas
authors.initials: A
authors.lastname: Neumann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary; D000075202:Contraindications; D003362:Cost-Benefit Analysis; D004724:Endoscopy / Q000191:economics; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000191:economics; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed