Haematological and histological findings in birds experimentally infected with highly pathogenic H5N2 avian influenza virus.
Experimental infection of specific-pathogen-free (SPF) Leghorn chickens with a highly pathogenic H5N2 avian influenza virus produced cellular hyperplasia in the bone marrow at 36 hours post infection (hpi) and haematological evidence of monocytosis, thrombocytopenia and heterophilia was also detected. An early, significant and progressive haematological change was thrombocytopenia starting at 24 hpi without an increase of prothrombin time. The findings suggest that highly pathogenic avian influenza virus interferes only with the primary haemostatic mechanisms by consumption of thrombocytes, while the secondary haemostatic mechanisms remain intact.
Ramírez
Guadalupe
G
Department of Pathology, Section of Clinical Diagnosis, Faculty of Veterinary Medicine and Animal Science, National Autonomous University of Mexico.
Fehervari
T
T
Paasch
L H
LH
Calderón
Norma L
NL
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000821:virology; D001853:Bone Marrow / Q000473:pathology / Q000821:virology; D001921:Brain / Q000821:virology; D002645:Chickens; D006470:Hemorrhage / Q000503:physiopathology / Q000662:veterinary / Q000821:virology; D053125:Influenza A Virus, H5N2 Subtype / Q000472:pathogenicity* / Q000502:physiology; D005585:Influenza in Birds / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology / Q000821:virology; D007668:Kidney / Q000821:virology; D008168:Lung / Q000821:virology; D011517:Prothrombin Time / Q000662:veterinary; D011531:Proventriculus / Q000821:virology; D013047:Specific Pathogen-Free Organisms