Association between migraine and HLA-DRB1 gene polymorphisms.
We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA-DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA-DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.
Rainero
Innocenzo
I
Neurology III-Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126, Turin, Italy. irainero@molinette.piemonte.it
Fasano
Edvige
E
Rubino
Elisa
E
Rivoiro
Chiara
C
Valfrè
Walter
W
Gallone
Salvatore
S
Savi
Lidia
L
Gentile
Salvatore
S
Lo Giudice
Rossana
R
De Martino
Paola
P
Dall'Omo
Anna Maria
AM
Pinessi
Lorenzo
L
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000235:genetics*; D020326:Migraine without Aura / Q000235:genetics*; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains