[Quercetin and hesperidin decrease the formation of nitric oxide radicals in rat liver and heart under the conditions of hepatosis].
The formation of nitric oxide radicals in the organs of Wistar rats was studied by the ESR method using ferrous-diethyldithiocarbamate complexes as an NO spin trap. It was found that, under the conditions of CCl4-induced hepatosis, a 4.32-5.46-fold increase in the concentrations of NO radical spin adducts in the samples of heart and liver, correspondingly, occurs. After preliminary intraperoral introduction of quercetin and hesperidin, this effect was not observed. Thus, the flavonoids quercetin and hesperidin exert a distinct antioxidant action, substantialy suppressing the hepatosis-induced increase in the intensity of NO radical generation.
Timoshin
A A
AA
Dorkina
E G
EG
Paukova
E O
EO
Vanin
A F
AF
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006569:Hesperidin / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D011794:Quercetin / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
D005609:Free Radicals; D009569:Nitric Oxide; D011794:Quercetin; D002251:Carbon Tetrachloride; D006569:Hesperidin