title: Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence.
abstract: A wbpP gene encoding a putative UDP-N-acetyl-D-glucosamine C(4) epimerase was identified and cloned from Vibrio vulnificus. The functions of the wbpP gene, assessed by the construction of an isogenic mutant and by evaluating its phenotype changes, demonstrated that WbpP is essential in both the pathogenesis and the capsular polysaccharide biosynthesis of V. vulnificus.
authors.affiliation: Department of Food Science and Technology, School of Agricultural Biotechnology, Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742, South Korea.
authors.forename: Na Young
authors.initials: NY
authors.lastname: Park
authors.forename: Jeong Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Myung Won
authors.initials: MW
authors.lastname: Kim
authors.forename: Hee Gon
authors.initials: HG
authors.lastname: Jeong
authors.forename: Byung Cheol
authors.initials: BC
authors.lastname: Lee
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Kim
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000818:Animals; D016667:Bacterial Capsules / Q000096:biosynthesis / Q000235:genetics; D002238:Carbohydrate Epimerases / Q000235:genetics* / Q000502:physiology; D003001:Cloning, Molecular; D004847:Epithelial Cells / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D014735:Vibrio Infections / Q000201:enzymology / Q000473:pathology; D041261:Vibrio vulnificus / Q000201:enzymology / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
chemical_list: D002238:Carbohydrate Epimerases; C023223:UDP-N-acetylglucosamine 4-epimerase