Quantitative tissue blood flow evaluation of pancreatic tumor: comparison between xenon CT technique and perfusion CT technique based on deconvolution analysis.
OBJECTIVE
There has been one report that tissue blood flow (TBF) quantification with xenon CT was effective in predicting the therapeutic response to an anticancer drug in pancreatic cancer. The purpose of this study was to evaluate the correlation between the TBF of pancreatic tumors calculated with xenon CT and those with perfusion CT, in order to evaluate whether perfusion CT could replace xenon CT.


METHODS
Nine patients with pathologically proved pancreatic tumors who underwent both xenon CT and perfusion CT were included.


RESULTS
Quantitative TBF of pancreatic tumors measured by perfusion CT ranged from 22.1 to 196.2 ml/min/100 g (mean+/-SD, 52.6+/-54.8 ml/min/100 g). In contrast, those obtained by xenon CT ranged from 10.3 to 173.6 ml/min/100 g (mean+/-SD, 47.4+/-49.4 ml/min/100 g). There was a good linear correlation between xenon CT and perfusion CT (y=0.8537x+2.48, R2=0.895: p<0.05).


CONCLUSIONS
The TBF of pancreatic tumors measured by xenon CT and perfusion CT techniques showed a close linear correlation. We can expect that perfusion CT based on the deconvolution algorithm may replace xenon CT to predict the effect of pancreatic tumor treatment with anticancer drugs.
Abe
Hisashi
H
Department of Radiology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565-0871, Japan.
Murakami
Takamichi
T
Kubota
Masaru
M
Kim
Tonsok
T
Hori
Masatoshi
M
Kudo
Masayuki
M
Hashimoto
Kazuhiko
K
Nakamori
Shoji
S
Dono
Keizo
K
Tomoda
Kaname
K
Monden
Morito
M
Nakamura
Hironobu
H
D000230:Adenocarcinoma / Q000098:blood supply* / Q000000981:diagnostic imaging; D007516:Adenoma, Islet Cell / Q000098:blood supply* / Q000000981:diagnostic imaging; D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D036542:Tomography, Spiral Computed / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014978:Xenon / Q000008:administration & dosage*
D003287:Contrast Media; D014978:Xenon