title: Role of HCV coinfection towards disease progression and survival in HIV-1 infected children: a follow-up study of 10 years.
abstract: The present study was taken up to evaluate the pattern of disease progression and survival in a group of HIV-1 positive children, coinfected with HCV infection (n=25) in comparison to those without such coinfection (n=23). There was a significant negative correlation between the rate of decline of the CD4 + T cell percentage and the duration of the AIDS-free interval in most (80.0 per cent) of the HCV seropositive children showing such decline (r=-0.588; p=0.005). The HCV seropositive children had twofold higher risk of progression to development of AIDS than HCV seronegatives (RR=2.51; 95 per cent CI:1.34-4.69; p=0.004). There was a significant negative correlation between the rate of decline of CD4 + T cell percentage and overall survival duration for HCV seropositive group (r=-0.609; p=0.003). Moreover, children coinfected with HCV had more than twofold higher risks of death than those without HCV (RR=2.39; 95 per cent CI:1.17-4.89; p<0.01). It appears that HCV infection may be an important contributor to the rapid disease progression and increase in mortality in HCV-HIV-1 coinfected children of thalassemia major.
authors.affiliation: Department of Statistics, University of Delhi, Delhi, India.
authors.forename: Swami Onkar
authors.initials: SO
authors.lastname: Shivraj
authors.forename: Debasish
authors.initials: D
authors.lastname: Chattopadhya
authors.forename: Gurprit
authors.initials: G
authors.lastname: Grover
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Usha K
authors.initials: UK
authors.lastname: Baveja
mesh_terms: D018791:CD4 Lymphocyte Count; D002648:Child; D018450:Disease Progression; D005500:Follow-Up Studies; D015658:HIV Infections / Q000401:mortality / Q000503:physiopathology / Q000821:virology*; D015497:HIV-1; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007194:India / Q000453:epidemiology; D011446:Prospective Studies; D012189:Retrospective Studies; D012306:Risk; D015996:Survival Rate; D013789:Thalassemia / Q000821:virology; D065227:Transfusion Reaction