Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.
Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.
Bian
Xiaoli
X
School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.
He
Langchong
L
Yang
Guangde
G
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001600:Berberine Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D001600:Berberine Alkaloids; D007004:Hypoglycemic Agents; C009090:protoberberine; D000496:Alloxan