[Control of gene transcription as a new therapeutic target in asthma].
The recent advances in the knowledge of the molecular mechanisms underlying asthma have lead to a significant improvement of the current treatments of the disease and opened new perspectives for the development of therapeutic alternatives to inhaled corticosteroids. The selective targeting of transcription factors controlling the expression of the genes implicated in the pathogenesis of asthma is one of these privileged strategies. This review aims at describing the most promising new therapeutic targets in the control of asthmatic inflammation at the gene transcription level.
Desmet
C
C
Département de Physiologie, Faculté de Médecine Vétérinaire, Centre de Thérapie Cellulaire et Moléculaire, ULg.
Louis
R
R
Lekeux
P
P
Bureau
F
F
D001249:Asthma / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
D014157:Transcription Factors