title: Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: a potential role for recombinant factor VIIa.
abstract: Necrotizing enterocolitis remains a serious condition in very low birth weight infants, particularly in those infants who require surgery. Perioperative hemorrhage is a potentially fatal complication in this population. We describe our experience in 4 premature infants with necrotizing enterocolitis who received recombinant factor VIIa to manage life-threatening intraoperative hemorrhage.
authors.affiliation: Department of Neonatology, Royal Children's Hospital, Melbourne, Australia. peter.filan@rch.org.au
authors.forename: Peter M
authors.initials: PM
authors.lastname: Filan
authors.forename: John F
authors.initials: JF
authors.lastname: Mills
authors.forename: Tom D
authors.initials: TD
authors.lastname: Clarnette
authors.forename: Henry
authors.initials: H
authors.lastname: Ekert
authors.forename: Paul
authors.initials: P
authors.lastname: Ekert
mesh_terms: D020345:Enterocolitis, Necrotizing / Q000601:surgery*; D015942:Factor VIIa / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007431:Intraoperative Complications / Q000188:drug therapy*; D007813:Laparotomy; D008107:Liver Diseases / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012422:Rupture, Spontaneous; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa