[The effect of Asian cobra venom on the content of rat heart and liver mitochondrial phospholipids and the protective effect of benzonal].
Administration of a cobra venom to rats resulted in decrease of heart and liver mitochondrial cardiolipins (1.88 and 1.82 times), phosphatidylethanolamines (1.56 and 1.42 times) and phosphatidic acid (1.14 and 1.29 times), whereas the content of phosphadtidylcholins increased by 1.42 and 1.51-fold, respectively. The content of phosphadtidylinositol increased by 3.09 times in liver mitochondria and decreased by 1.28 times in heart mitochondria. Administration of benzonal not only normalized liver mitochondrial phosphadtidylserine content impaired after the venom administration but even exceeded it. Benzonal also minimized changes in mitochondrial phospholipid induced by the cobra venom, and also reduced liver and heart phosphatidic acid content by 1.36 and 1.7 times.
Shirinova
I A
IA
Nurdinov
Sh Sh
ShSh
Klemesheva
L S
LS
Almatov
K T
KT
D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D004546:Elapid Venoms / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D008929:Mitochondria, Heart / Q000737:chemistry / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000737:chemistry / Q000187:drug effects*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D001463:Barbiturates; D004546:Elapid Venoms; D010743:Phospholipids; C002915:benzobarbital