Increased plasma levels of thioredoxin in patients with glucose intolerance.
OBJECTIVE
The aim of the present study was to determine the effects of glucose intolerance on oxidative stress in patients with coronary artery disease (CAD).


METHODS
The patients were divided into 3 groups, diabetes mellitus (DM), IGT or normal glucose tolerance (NGT) according to the criteria of the American Diabetes Association.


METHODS
The present study consisted of 178 consecutive patients who underwent diagnostic coronary arteriography and a 75-g glucose tolerance test.


RESULTS
The level of plasma thioredoxin, a marker of oxidative stress was measured in every patient during the fasting state. The levels of plasma thioredoxin were significantly higher in the DM and IGT groups than the NGT group. Furthermore, we found that there was a positive association between thioredoxin levels and glycosylated hemoglobin (sigma=0.225, p=0.018). In multivariate logistic regression analysis, glucose intolerance (DM or IGT) was only independently associated with the high levels of thioredoxin. The levels of plasma thioredoxin were significantly higher in the CAD group compared to the non-CAD group. In multivariate logistic regression analysis, high levels of thioredoxin, male, age and hypertension were independently associated with the presence of CAD.


CONCLUSIONS
Glucose intolerance was associated with the high levels of thioredoxin. High levels of thioredoxin were related to the presence of CAD. The measurement of thioredoxin as the marker of oxidative stress may be useful for monitoring the development of the cardiovascular diseases.
Miyamoto
Shinzo
S
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
Kawano
Hiroaki
H
Hokamaki
Jun
J
Soejima
Hirofumi
H
Kojima
Sunao
S
Kudoh
Takashi
T
Nagayoshi
Yasuhiro
Y
Sugiyama
Seigo
S
Sakamoto
Tomohiro
T
Yoshimura
Michihiro
M
Nakamura
Hajime
H
Yodoi
Junji
J
Ogawa
Hisao
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000150:complications; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D011379:Prognosis; D012307:Risk Factors; D013879:Thioredoxins / Q000097:blood*
D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D013879:Thioredoxins