An arabinogalactan isolated from the stems of Cistanche deserticola induces the proliferation of cultured lymphocytes.
A purified polysaccharide ACDP-2 was isolated from water extract of the stems of Cistanche deserticola. Chemical and spectroscopic analyses indicated that ACDP-2 is a highly branched arabinogalactan polymer that composes of linked d-galactopyranose and d-glucopyranose, which contains predominantly a branching point at the 6-carbon. The branched side-chains compose of terminal-, 1,5-, and 1,3,5-linked arabinofuranosyl residues. ACDP-2 showed an effect in stimulating the immune response, which when applied onto the cultured mouse lymphocytes induced the cell proliferation in a dose-dependent manner.
Wu
Xiang Mei
XM
Modern Research Center for Traditional Chinese Medicine, School of Pharmaceutical Sciences, Beijing 100083, China.
Gao
Xiao Ming
XM
Tsim
Karl W K
KW
Tu
Peng Fei
PF
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D031671:Cistanche; D005685:Galactans / Q000737:chemistry / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems
D005685:Galactans; D008934:Mitogens; C005653:arabinogalactan