Allosensitization in patients receiving multiple blood transfusions.
Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and 153 dollars extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.
Sakhalkar
V S
VS
Department of Pediatrics, Louisiana State University Health Science Center at Shreveport, Feist-Weiller Cancer Center, 1501 Kings Hwy., P.O. Box 33932, Shreveport, LA 71130-3932, USA. Vishwas@pol.net
Roberts
K
K
Hawthorne
L M
LM
McCaskill
D M
DM
Veillon
D M
DM
Caldito
G C
GC
Cotelingam
J D
JD
D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000097:blood / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000276:immunology; D001788:Blood Grouping and Crossmatching; D002648:Child; D002675:Child, Preschool; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007114:Immunization; D015994:Incidence; D007223:Infant; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D001323:Autoantibodies; D001789:Blood Group Antigens; D007518:Isoantibodies