Poxviruses aren't stuPYD.
Pathogens utilize many strategies to dampen the host inflammatory response. In this issue of Immunity, a report by Johnston and colleagues reveals a poxvirus strategy that inhibits the inflammasome, arresting secretion of interleukin-1-related cytokines, thus silencing key alarms that mobilize host defenses.
Benedict
Chris A
CA
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.
Ware
Carl F
CF
D007249:Inflammation / Q000276:immunology* / Q000821:virology; D007375:Interleukin-1 / Q000096:biosynthesis*; D018448:Models, Immunological; D009233:Myxoma virus / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology* / Q000378:metabolism*
D007375:Interleukin-1; D014764:Viral Proteins