Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage.
The ability of engineered cerium oxide nanoparticles to confer radioprotection was examined. Human normal and tumor cells were treated with nanoceria and irradiated, and cell survival was measured. Treatment of normal cells conferred almost 99% protection from radiation-induced cell death, whereas the same concentration showed almost no protection of tumor cells. For the first time, nanoceria is shown to confer radioprotection to a normal human breast line but not to a human breast tumor line, MCF-7.
Tarnuzzer
Roy W
RW
M. D. Anderson Cancer Center Orlando, Orlando Regional Healthcare, Orlando, FL 32806, USA. rtarnuzzer@cfl.rr.com
Colon
Jimmie
J
Patil
Swanand
S
Seal
Sudipta
S
D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001698:Biomedical Engineering / Q000379:methods; D001940:Breast / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000473:pathology*; D002563:Cerium / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods*; D011836:Radiation Tolerance / Q000187:drug effects; D014407:Tumor Cells, Cultured
D004304:Dosage Forms; D002563:Cerium; C030583:ceric oxide