title: Problems associated with biological markers of Alzheimer's disease.
abstract: The etiopathogenesis of Alzheimer's disease (AD) is still unclear, although clinical diagnostic criteria exist and the neuropathology of AD has been studied in great detail during the last 20 years. The present study addresses certain problems in the search for biological markers for the diagnosis, as well as in the follow-up of the course of AD and its differential diagnosis and reports some of our own observations in comparison with other studies. These include protein, genetic and neuroimaging markers. The definitions of biological markers and search strategies are also discussed.
authors.affiliation: Brain Research Center, University of Tampere, Medical School, Building B, FIN-33014, Tampere, Finland. harry.frey@uta.fi
authors.forename: H J
authors.initials: HJ
authors.lastname: Frey
authors.forename: K M
authors.initials: KM
authors.lastname: Mattila
authors.forename: M A
authors.initials: MA
authors.lastname: Korolainen
authors.forename: T
authors.initials: T
authors.lastname: Pirttilä
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D015415:Biomarkers; D003952:Diagnostic Imaging; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D040901:Proteomics
chemical_list: D015415:Biomarkers