Reversibility of hypogonadotropic hypogonadism in a patient with the juvenile form of hemochromatosis.
OBJECTIVE
To report a case of complete reversibility of hypogonadotropic hypogonadism with intensive venesection treatment in juvenile hemochromatosis.


METHODS
Case report.


METHODS
Endocrine department of Hippocrateion Hospital of Athens.


METHODS
A 25-year-old man who presented with hypogonadotropic hypogonadism and severe iron overload due to juvenile hemochromatosis and who was initially treated with phlebotomies and androgen substitution.


METHODS
Intensification of chelation therapy.


METHODS
Clinical evaluation, serum ferritin concentration, and biochemical assessment of pituitary function were performed periodically.


RESULTS
One year after normalization of serum ferritin levels and transferrin saturation was achieved, he became eugonadal.


CONCLUSIONS
We believe that hypogonadotropic hypogonadism in juvenile hemochromatosis may be reversible by a consequent venesection therapy probably because treatment was intensive and promptly introduced at a young age.
Angelopoulos
Nicholas G
NG
Endocrine Department, Hippokrateion Hospital of Athens, Athens, Greece. drangelnick@hotmail.com
Goula
Anastasia
A
Dimitriou
Evagelos
E
Tolis
George
G
D000328:Adult; D000367:Age Factors; D005293:Ferritins / Q000097:blood; D006432:Hemochromatosis / Q000150:complications* / Q000628:therapy*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology* / Q000628:therapy*; D008297:Male; D018962:Phlebotomy; D012074:Remission Induction; D014168:Transferrin / Q000378:metabolism
D014168:Transferrin; D005293:Ferritins