title: Cortical laminar necrosis related to prolonged focal status epilepticus.
abstract: Cortical laminar necrosis (CLN) is radiologically defined as high intensity cortical lesions on T1 weighted MRI images following a gyral distribution. Histopathologically, CLN is characterised by pannecrosis of the cortex involving neurones, glial cells, and blood vessels. It has been reported to be associated with hypoxia, metabolic disturbances, drugs, and infections. We present two patients who developed CLN and permanent neurological deficits after prolonged and repeated focal status epilepticus. The possible mechanisms leading to CLN in these patients are discussed, together with the implications of prompt and aggressive treatment in similar cases.
authors.affiliation: Hospital Clínic de Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Donaire
authors.forename: M
authors.initials: M
authors.lastname: Carreno
authors.forename: B
authors.initials: B
authors.lastname: Gómez
authors.forename: P
authors.initials: P
authors.lastname: Fossas
authors.forename: N
authors.initials: N
authors.lastname: Bargalló
authors.forename: R
authors.initials: R
authors.lastname: Agudo
authors.forename: M
authors.initials: M
authors.lastname: Falip
authors.forename: X
authors.initials: X
authors.lastname: Setoaín
authors.forename: T
authors.initials: T
authors.lastname: Boget
authors.forename: T
authors.initials: T
authors.lastname: Raspall
authors.forename: V
authors.initials: V
authors.lastname: Obach
authors.forename: J
authors.initials: J
authors.lastname: Rumiá
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001041:Aphasia, Wernicke / Q000175:diagnosis / Q000209:etiology; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D007839:Functional Laterality; D006423:Hemianopsia / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D010291:Paresis / Q000175:diagnosis / Q000209:etiology; D010672:Phenytoin / Q000627:therapeutic use; D010889:Piracetam / Q000031:analogs & derivatives / Q000627:therapeutic use; D013226:Status Epilepticus / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010672:Phenytoin; D010889:Piracetam