title: Outcome of periocular basal cell carcinoma managed by overnight paraffin section.
abstract: BACKGROUND
  Surgical excision of periocular skin cancer allows for optimum control in terms of tumour recurrence. Although Mohs' technique gives the best outcome, it is not widely available. Processing paraffin sections is slower but histologically superior to Mohs' frozen sections. We report the results of using a standard paraffin section (non-Mohs') technique to confirm histological clearance.
  
  
  METHODS
  A retrospective study between 1/6/95 and 1/6/99 of all consecutive patients who had excision of periocular cancer was performed. All patients had surgical excision of the tumour with a 3-mm margin. Rapid (24-hour) paraffin sections were done and reconstruction performed if histological clearance was confirmed. If tumour was still present, a further 3-mm margin was excised at the appropriate edge(s) before reconstruction took place.
  
  
  RESULTS
  This study yielded 93 basal cell carcinomas (BCCs) of which 86 were of primary origin and 7 were recurrent tumours. The tumour characteristics were as follows: 88% nodular BCCs, 82% had a maximum surface measurement less than or equal to 10 mm, 39.8% were inner canthal and 49.5% were localised to the lower lid. In the 30 (35.4%) cases that required further excision based on the initial histological reports, tumour was seen in only four (11.4%) cases. Overall histological clearance for primary BCCs was achieved in 81/86 (94.2%) cases. There was only one late recurrence at 4 years and 5 months. Among recurrent BCCs, there was one recurrence (12.5%) and this was despite histological clearance having been reported.
  
  
  CONCLUSIONS
  For primary BCCs the recurrence rate in this study was low and comparable to that following Mohs' technique. This approach, using routine pathological facilities, therefore offers a viable technique for managing periocular BCCs.
authors.affiliation: Department of Ophthalmology, Leeds General Infirmary, Belmont Grove, Leeds, UK.
authors.forename: Mona A
authors.initials: MA
authors.lastname: Khandwala
authors.forename: Shelly-Anne
authors.initials: SA
authors.lastname: Lalchan
authors.forename: Bernard Y P
authors.initials: BY
authors.lastname: Chang
authors.forename: Maged
authors.initials: M
authors.lastname: Habib
authors.forename: A
authors.initials: A
authors.lastname: Chakrabarty
authors.forename: Andy
authors.initials: A
authors.lastname: Cassells-Brown
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery*; D005142:Eyelid Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D016612:Paraffin Embedding / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome