[The role of copper and magnesium in the pathogenesis and treatment of affective disorders].
Magnesium and copper are important modulators of NMDA-receptor activity. Recent data indicate that disturbances of glutamatergic transmission (especially via NMDA-receptor) are involved in pathogenesis of mood disorders. Magnesium deficiency, the same as disturbances in turn over of copper, are related to a variety of psychological symptoms especially depression. There are many reports indicating significant changes in blood levels of magnesium or copper during a depressive episode. Moreover magnesium exhibits antidepressant-like and anxiolytic-like effects in animal models of depression, in rodents. This article reviews the alterations in central and peripheral magnesium and copper homeostasis in relation to pathophysiology and treatment of depression.
Siwek
Marcin
M
Klinika Psychiatrii Dorosłych CM UJ.
Wróbel
Andrzej
A
Dudek
Dominika
D
Nowak
Gabriel
G
Zieba
Andrzej
A
D000818:Animals; D000928:Antidepressive Agents / Q000097:blood / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003300:Copper / Q000097:blood / Q000627:therapeutic use; D018698:Glutamic Acid / Q000187:drug effects / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D019964:Mood Disorders / Q000188:drug therapy* / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000378:metabolism
D000928:Antidepressive Agents; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D003300:Copper; D008274:Magnesium