Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: a potential role for recombinant factor VIIa.
Necrotizing enterocolitis remains a serious condition in very low birth weight infants, particularly in those infants who require surgery. Perioperative hemorrhage is a potentially fatal complication in this population. We describe our experience in 4 premature infants with necrotizing enterocolitis who received recombinant factor VIIa to manage life-threatening intraoperative hemorrhage.
Filan
Peter M
PM
Department of Neonatology, Royal Children's Hospital, Melbourne, Australia. peter.filan@rch.org.au
Mills
John F
JF
Clarnette
Tom D
TD
Ekert
Henry
H
Ekert
Paul
P
D020345:Enterocolitis, Necrotizing / Q000601:surgery*; D015942:Factor VIIa / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007431:Intraoperative Complications / Q000188:drug therapy*; D007813:Laparotomy; D008107:Liver Diseases / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012422:Rupture, Spontaneous; D016896:Treatment Outcome
D011994:Recombinant Proteins; D015942:Factor VIIa