title: Dysfunction of lamin A triggers a DNA damage response and cellular senescence.
abstract: In higher eukaryotes, the nuclear lamins play an important role in maintaining the integrity of the nuclear envelope and the nucleus itself. Two recent papers show that a mutation that affects the processing of one of the nuclear lamins, lamin A, results in increased sensitivity to DNA damaging agents, an elevated DNA damage response, and a senescent phenotype. These studies underscore the role of the nuclear envelope in maintaining genomic stability and the interplay between nuclear architecture and the DNA damage response.
authors.affiliation: Department of Biochemistry & Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alta., Canada T2N 4N1. leesmill@ucalgary.ca
authors.forename: Susan P
authors.initials: SP
authors.lastname: Lees-Miller
mesh_terms: D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D016922:Cellular Senescence; D004249:DNA Damage; D006801:Humans; D034904:Lamin Type A / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D034882:Lamins / Q000378:metabolism; D009154:Mutation; D009685:Nuclear Envelope / Q000378:metabolism; D034881:Nuclear Lamina / Q000378:metabolism; D015530:Nuclear Matrix / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010641:Phenotype
chemical_list: D034904:Lamin Type A; D034882:Lamins; D009687:Nuclear Proteins