Taurine interaction with neurotransmitter receptors in the CNS: an update.
Taurine appears to have multiple functions in the brain participating both in volume regulation and neurotransmission. In the latter context it may exert its actions by serving as an agonist at receptors of the GABAergic and glycinergic neurotransmitter systems. Its interaction with GABAA and GABAB receptors as well as with glycine receptors is reviewed and the physiological relevance of such interactions is evaluated. The question as to whether local extracellular concentrations of taurine are likely to reach the threshold level for the pertinent receptor populations cannot presently be answered satisfactorily. Hence more sophisticated analytical methods are warranted in order to obtain a definite answer to this important question.
Albrecht
Jan
J
Department of Neurotoxicology, Medical Research Centre, Polish Academy of Sciences, Pawińskiego St. 5, 02-106, Warsaw, Poland. jalb@cmdik.pan.pl
Schousboe
Arne
A
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism*
D017981:Receptors, Neurotransmitter; D013654:Taurine