title: Plasma levels of insulin and amyloid beta 42 are correlated in patients with amnestic Mild Cognitive Impairment.
abstract: Epidemiological and experimental data suggest that type 2 diabetes (DM2) and sporadic late-onset Alzheimer's disease (AD) share a common mechanism, that is able to produce accumulation of insulin and amyloid beta 42 (Abeta42), the major pathogenic events respectively of the two conditions. In 71 non diabetic patients with amnestic mild cognitive impairment we found a significant linear correlation between fasting plasma levels of insulin and Abeta42 (R = +0.25, P < 0.05). The levels of both peptides were elevated in comparison to 48 age-matched cognitively normal controls. The correlation of insulin and Abeta42 plasma levels suggests a pathogenic link between DM2 and sporadic AD.
authors.affiliation: Gerontology and Geriatrics, Department of Internal Medicine University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy.
authors.forename: Patrizio
authors.initials: P
authors.lastname: Odetti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Piccini
authors.forename: Luca
authors.initials: L
authors.lastname: Giliberto
authors.forename: Roberta
authors.initials: R
authors.lastname: Borghi
authors.forename: Alessia
authors.initials: A
authors.lastname: Natale
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Monacelli
authors.forename: Monica
authors.initials: M
authors.lastname: Marchese
authors.forename: Andrea
authors.initials: A
authors.lastname: Assini
authors.forename: Monica
authors.initials: M
authors.lastname: Colucci
authors.forename: Sergio
authors.initials: S
authors.lastname: Cammarata
authors.forename: Massimo
authors.initials: M
authors.lastname: Tabaton
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism; D000647:Amnesia / Q000453:epidemiology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003072:Cognition Disorders / Q000453:epidemiology / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D016229:Amyloid beta-Peptides; D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)