Filtering transcriptional noise during development: concepts and mechanisms.
The assignation of cell fates during eukaryotic development relies on the coordinated and stable expression of cohorts of genes within cell populations. The precise and reproducible nature of this process is remarkable given that, at the single-cell level, the transcription of individual genes is associated with noise - random molecular fluctuations that create variability in the levels of gene expression within a cell population. Here we consider the implications of transcriptional noise for development and suggest the existence of molecular devices that are dedicated to filtering noise. On the basis of existing evidence, we propose that one such mechanism might depend on the Wnt signalling pathway.
Arias
Alfonso Martinez
AM
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. ama11@hermes.cam.ac.uk
Hayward
Penelope
P
D000818:Animals; D019070:Cell Lineage; D003599:Cytoskeleton / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D016678:Genome; D006801:Humans; D008390:Markov Chains; D008957:Models, Genetic; D051880:Receptors, Notch / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
D051880:Receptors, Notch; D051153:Wnt Proteins; D051176:beta Catenin