[Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age].
OBJECTIVE
To study polymorphisms of genes of factors of the system of hemostasis in young patients with ischemic heart disease (IHD).


METHODS
Two groups of patients participated in the study: patients with first manifestation of IHD at the age < or = 50 years (men) or < or = 55 years (women) (n=158), and patients with first IHD manifestation at the age > or = 70 years (n=92).


METHODS
We studied polymorphic markers of genes encoding clotting factors V (F5) and VII (F7), subunit IIIa of platelet integrin (ITGB3), beta-chain of fibrinogen (FGB) and tissue plasminogen activator type 1 (PLANH1).


RESULTS
After separation of a subgroup of patients with MI without preceding angina we revealed significant differences in distribution of frequencies of genotypes of polymorphic marker C(-426)T of factor V gene: genotype TT was significantly more frequent in young (14.9%) than in old (2%) patients (p=0.008). Multifactorial logistic regression revealed independent association of early IHD with smoking (OR 6.112 [2.567-14.552]; p<0.001) and presence of genotype TT of C(-426)T polymorphic marker of F5 gene (OR=9.410 [1.074-82.459]; p=0.043).


CONCLUSIONS
Thus we obtained data on the presence of independent association between IHD risk and manifestation of MI in young age with genotype TT of polymorphic marker C(-426)T of F5 gene as well as with traditional risk factors of IHD.
Dankovtseva
E N
EN
Zateĭshchikov
D A
DA
Chudakova
D A
DA
Koroleva
O S
OS
Brovkin
A N
AN
Nosikov
V V
VV
Gaĭdukova
N V
NV
Tishchenko
V A
VA
Sidorenko
B A
BA
D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D001779:Blood Coagulation Factors / Q000235:genetics*; D003627:Data Interpretation, Statistical; D005165:Factor V / Q000235:genetics; D005167:Factor VII / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000235:genetics; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D017202:Myocardial Ischemia / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D010959:Tissue Plasminogen Activator / Q000235:genetics
D001779:Blood Coagulation Factors; D005165:Factor V; D005167:Factor VII; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator