Seprafilm does not aggravate intraperitoneal septic conditions or evoke systemic inflammatory response.
OBJECTIVE
To determine whether Seprafilm aggravates the systemic inflammatory response and adversely affects the outcome of postoperative intraperitoneal septic conditions.


METHODS
We retrospectively analyzed the relationship between the intraperitoneal placement of Seprafilm and the rate of intraperitoneal septic complications in 278 consecutive patients. Experimentally, 40 rats were subjected to laparotomy with or without the intraperitoneal placement of Seprafilm. Bacterial peritonitis was induced by cecal ligation and puncture (CLP) and the serum cytokine levels were measured.


RESULTS
Seprafilm did not increase the rate of septic complications or aggravate inflammatory responses in patients with or without postoperative intraperitoneal inflammatory complications. Experimentally, there was no significant difference between the serum inflammatory cytokine levels after CLP with or without Seprafilm.


CONCLUSIONS
Seprafilm did not adversely affect postoperative inflammatory response or clinical outcomes, even in patients with intraperitoneal septic complications.
Uchida
Keiichi
K
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Japan.
Urata
Hisashi
H
Mohri
Yasuhiko
Y
Inoue
Mikihiro
M
Miki
Chikao
C
Kusunoki
Masato
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010537:Peritoneum / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012189:Retrospective Studies; D018805:Sepsis / Q000517:prevention & control*; D018709:Statistics, Nonparametric; D018746:Systemic Inflammatory Response Syndrome / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000517:prevention & control
D015850:Interleukin-6; D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid; D002097:C-Reactive Protein