Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia.
FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in size from 3 to hundreds of nucleotides. We examined whether the sizes of FLT3/ITDs were associated with clinical outcomes in 151 AML patients enrolled in Southwest Oncology Group studies: S9333 and S9500. FLT3/ITDs were identified in 32% of patients (median ITD size = 39 nucleotides; range, 15-153 nucleotides). The CR rates were 35%, 67%, and 52% for patients with large (>or= 40), small (< 40), and no ITDs, respectively (P = .19). Increasing ITD size was associated with decreasing OS (estimated 5-year OS: large = 13%, small = 26%, and no ITD = 21%, P = .072) and RFS (estimated 5-year RFS: large = 13%, small = 27%, and no ITD = 34%, P = .017). These studies suggest that ITD size may have prognostic significance.
Stirewalt
Derek L
DL
Fred Hutchinson Cancer Research Center, D5-380, 1100 Fairview Ave N. Seattle, WA 98109, USA. dstirewa@fhcrc.org
Kopecky
Kenneth J
KJ
Meshinchi
Soheil
S
Engel
Julia H
JH
Pogosova-Agadjanyan
Era L
EL
Linsley
Jeremy
J
Slovak
Marilyn L
ML
Willman
Cheryl L
CL
Radich
Jerald P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D011379:Prognosis; D017434:Protein Structure, Tertiary; D015996:Survival Rate; D020080:Tandem Repeat Sequences; D051941:fms-Like Tyrosine Kinase 3 / Q000737:chemistry / Q000235:genetics*
C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3