Acyclic peptide inhibitors of amylases.
In this issue of Chemistry and Biology, a library screening approach reveals a linear octapeptide inhibitor of alpha-amylases reached by de novo design . The selected molecule shares characteristics with naturally occurring protein inhibitors -- a result that suggests general rules for the design of peptide-based amylase inhibitors may be achievable.
Pohl
Nicola
N
Department of Chemistry and The Plant Sciences Institute, Gilman Hall, Iowa State University, Ames, Iowa 50011, USA.
D000681:Amylases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000818:Animals; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy; D006801:Humans; D015394:Molecular Structure; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
D002241:Carbohydrates; D019151:Peptide Library; D010455:Peptides; D000681:Amylases