title: Combined therapy with luteinizing hormone releasing hormone agonist (LHRHa) and growth hormone (GH) in central precocious puberty.
abstract: Luteinizing Hormone Releasing Hormone analogues (LHRHa) are considered the treatment of choice in central precocious puberty (CPP). Final height after therapy is usually higher than the predicted one before treatment, but about 60% of patients do not reach their genetic target. The association of Growth Hormone (GH) with LHRHa could be useful in a subgroup of children with CPP and low growth velocity in order to obtain a higher final height with a complete expression of genetic potential. Moreover, in children with early puberty adopted from developing countries, predicted adult height is significantly greater when the combined therapy, GH and LHRHa, is employed. In this paper the rationale for adding GH to LHRHa is discussed and the clinical reports from the literature are presented.
authors.affiliation: Department of Pediatrics University of Parma, Parma, Italy. cecivolt@unipr.it
authors.forename: Cecilia
authors.initials: C
authors.lastname: Volta
authors.forename: Carla
authors.initials: C
authors.lastname: Regazzi
authors.forename: Juliette
authors.initials: J
authors.lastname: Ndaka
authors.forename: Rosa
authors.initials: R
authors.lastname: Vitale
authors.forename: Sergio
authors.initials: S
authors.lastname: Bernasconi
mesh_terms: D004359:Drug Therapy, Combination; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000188:drug therapy*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone