Oxidative stress in infants born to preeclamptic mothers.
BACKGROUND
Oxidative stress may play an important role in the pathophysiology of preeclampsia. An increase in lipid peroxidation products and a decrease in antioxidant activity in preeclamptic women have been reported in many papers. The objective of this study was to evaluate oxidative stress in infants born to preeclamptic mothers.


METHODS
Malondialdehyde (MDA) and glutathione (GSH) levels and glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were measured in cord plasma of infants born to preeclamptic (n = 18) or normotensive (n = 9) mothers.


RESULTS
Gestational age was similar in both groups. The mean birth weight was significantly lower in the preeclamptic group (P = 0.007). Maternal age, primigravidity, antenatal steroid use, premature rupture of the membranes, clinical chorioamnionitis and adverse neonatal outcomes including sepsis, respiratory distress syndrome and neonatal mortality did not differ between groups. Cesarean delivery was significantly higher in the preeclamptic group. There was no significant difference in cord plasma levels of MDA and GSH, and activity of GPx between the preeclamptic and control groups. SOD was found to be increased in preeclamptic group (P = 0.03).


CONCLUSIONS
We concluded that although cord plasma MDA levels were similar in both the preeclamptic and control groups, increased SOD activity might be an indicator of increased oxidative stress in infants born to preeclamptic mothers.
Tastekin
Ayhan
A
Division of Neonatology, Atatürk University Faculty of Medicine, Erzurum, Turkey. doktorayhan67@hotmail.com
Ors
Rahmi
R
Demircan
Berna
B
Saricam
Zeki
Z
Ingec
Metin
M
Akcay
Fatih
F
D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000097:blood*
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione