Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall.
Ependymal cells appear to be totally differentiated during the first 3 weeks in the mouse brain. Early during postnatal development ependymal cells differentiate and undergo metabolic activation, which is accompanied by increased glucose uptake. We propose that ependymal cells induce an overexpression of the glucose transporter, GLUT1, during the first 2 weeks after delivery in order to maintain the early metabolic activation. During the first postnatal day, GLUT1 is strongly induced in the upper region of the third ventricle and in the ventral area of the rostral cerebral aqueduct. During the next 4 days, GLUT1 is expressed in all differentiated ependymal cells of the third ventricle and in hypothalamic tanycytes. At the end of the first week, ependymal cell differentiation and GLUT1 overexpression is concentrated in the latero-ventral area of the aqueduct. We propose that ependymal cell differentiation and GLUT1 overexpression is a synchronous process in the ventricular wall.
Silva-Alvarez
Carmen
C
Departamento de Biología Celular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160C, Concepción, Chile.
Carrasco
Mónica
M
Balmaceda-Aguilera
Carolina
C
Pastor
Patricia
P
García
María de los Angeles
Mde L
Reinicke
Karin
K
Aguayo
Luis
L
Molina
Benedicto
B
Cifuentes
Manuel
M
Medina
Rodolfo
R
Nualart
Francisco
F
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D002552:Cerebral Ventricles / Q000033:anatomy & histology* / Q000254:growth & development / Q000378:metabolism; D004805:Ependyma / Q000166:cytology*; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL
D051272:Glucose Transporter Type 1; C495678:Slc2a1 protein, mouse