title: [Extracapsular spread as an ominous prognostic sign in laryngeal cancer].
abstract: OBJECTIVE
  Impact of extracapsular spread upon survival and recurrence rates in patients with laryngeal cancer.
  
  
  METHODS
  Retrospective analysis of 309 patients with pathologically confirmed regional metastases with and without extracapsular spread (144 and 165 patients respectively). To examine impact of clinical variables upon treatment outcomes we used logistic regression (logit) and Kaplan-Meier method to calculate 5-years disease free survival.
  
  
  RESULTS
  Extracapsular spread significantly reduced 5-years survival (40% vs 77%; p = 0.005) and increased regional recurrence rates (33% vs 12%; p = 0.0001).
  
  
  CONCLUSIONS
  Authors suggest use of radiotherapy after neck dissection in presence of extracapsular spread.
authors.affiliation: Klinika Otolaryngologii CMKP, Szpital Bródnowski, Warszawa.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Wachulski
authors.forename: Antoni
authors.initials: A
authors.lastname: Osmólski
authors.forename: Robert
authors.initials: R
authors.lastname: Osmólski
authors.forename: Joanna
authors.initials: J
authors.lastname: Forlot
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors