Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.
In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the open-field test to assess motor activity, it was confirmed that the DCP-LA effect is not due to increased motor activity. In the passive avoidance test to assess fear memory, DCP-LA had no effect on the latency of acquisition and retention for SAMP8. The results of the present study, thus, suggest that DCP-LA could improve age-related learning impairment by enhancing cognitive functions.
Yaguchi
Takahiro
T
Department of Physiology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Nagata
Tetsu
T
Mukasa
Takeshi
T
Fujikawa
Hirokazu
H
Yamamoto
Hideyuki
H
Yamamoto
Satoshi
S
Iso
Hiroyuki
H
Tanaka
Akito
A
Nishizaki
Tomoyuki
T
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002210:Caprylates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D007859:Learning Disabilities / Q000188:drug therapy* / Q000209:etiology; D019787:Linoleic Acid / Q000737:chemistry*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008818:Mice, Neurologic Mutants; D009043:Motor Activity / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects
C506022:8-(2-(2-pentyl-cyclopropylmethyl)cyclopropyl)octanoic acid; D002210:Caprylates; D019787:Linoleic Acid