Polymorphism of VDR gene--the most effective molecular marker of osteoporotic bone fractures risk within postmenopausal women from Wielkopolska region of Poland.
The major public health problem which will arise is a frequency of osteoporosis. The first manifestations of this disease are often bone fractures. Identification and evaluation of individual bone fracture risk will be the most effective way of solving the problem. Genetic determination of osteoporosis is unquestionable. The aim of this study is to detect which variants of genotypes lead to illness. We investigated 187 patients with osteoporosis (161 women, 26 men) and 19 healthy subjects. Polymorphisms of the following genes were investigated: OPG, VDR, ESR1, TGFB1 COL1A1, and BMP2. The statistically significant relationship between BMD value and T allele of Taq I VDR gene were found. Genotypes: aa, bb, TT of VDR gene occur more frequently in polish osteoporotic population in Wielkopolska region within patients with higher risk of bone fractures.
Horst-Sikorska
Wanda
W
Department of Family Medicine, Karol Marcinkowski Medical University, Poznań, Poland.
Wawrzyniak
Anna
A
Celczyńska-Bajew
Liliana
L
Marcinkowska
Michalina
M
Dabrowski
Sebastian
S
Kalak
Robert
R
Słomski
Ryszard
R
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015992:Body Mass Index; D015519:Bone Density / Q000235:genetics*; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000235:genetics*; D015663:Osteoporosis, Postmenopausal / Q000235:genetics; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors
D005819:Genetic Markers; D018167:Receptors, Calcitriol