Synthesis of 8-aminoadenosine 5'-(aminoalkyl phosphates), analogues of aminoacyl adenylates.
A short and efficient route for the synthesis of aminoalkyl 8-aminoadenylates, potential aminoacyl-tRNA synthetase inhibitors, is presented. Aminoalkyl 8-aminoadenylates were synthesized using a 5'-H-phosphonate strategy involving minimal protecting group manipulations and a single final deprotection step.
Yousefi-Salakdeh
Esmail
E
Division of Organic and Bioorganic Chemistry, MBB, Scheele Laboratory, Karolinska Institutet, S-17177 Stockholm, Sweden.
Murtola
Merita
M
Zetterberg
Anders
A
Yeheskiely
Esther
E
Strömberg
Roger
R
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000031:analogs & derivatives*; D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy
D004791:Enzyme Inhibitors; D000249:Adenosine Monophosphate; D000604:Amino Acyl-tRNA Synthetases; D000241:Adenosine