Selenium, a versatile trace element: current research implications.
Selenium (Se), a trace element, has evolved from its toxic properties to an essential element. Se was known a potent antioxidant through glutathione peroxidase (selenium being part of this molecule). Later, many other selenium-binding proteins were discovered and their functions were tried to be known with unsuccessful results in many cases. Se is known to be involved in carcinogenesis, immune function, male reproduction, cardiovascular diseases etc. The specific mechanism of the involvement of the element is still not known. Recent research with application of modern research tools viz. bioinformatics, cDNA microarray and transgenesis have revealed the mechanism of selenium involvement in various processes. This review highlights mysterious and useful roles of selenium in biological processes.
Bansal
M P
MP
Department of Biophysics, Panjab University, Chandigarh 160 014, India. mpbansal@pu.ac.in
Kaur
Parminder
P
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D012643:Selenium / Q000008:administration & dosage / Q000502:physiology* / Q000633:toxicity; D014131:Trace Elements / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
D000975:Antioxidants; D014131:Trace Elements; D012643:Selenium