Stem cell pharmacogenomics: a reality check on stem cell therapy.
Widespread applications of stem cell-based therapies in the clinic are being reported, yet there is a surprising lack of resolution of the factors that lead to failure of such therapies on a long-term basis. While classical pharmacogenomics aids the prediction of drug responses in an individual based on genetic variation and pharmacological responses, stem cell therapy involves an additional dimension of host-donor cell interactions and adaptability. We propose the development of concise guidelines based on pharmacogenetic and donor/host-related cellular factors studied more extensively in larger data sets, and used in prospective studies to individualize stem cell therapy.
Bapat
Sharmila A
SA
National Centre for Cell Science, Ganeshkhind, Pune 411007, India. sabapat@nccs.res.in
Mishra
Gyan C
GC
D006086:Graft vs Host Disease / Q000150:complications / Q000628:therapy; D006801:Humans; D007165:Immunosuppression Therapy; D010597:Pharmacogenetics; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000378:metabolism*