title: Stereospecific reduction of ethyl 2' -ketopantothenate to ethyl d-(+)-pantothenate with microbial cells as a catalyst.
abstract: A novel enzymatic process for the synthesis of D-(+)-pantothenic acid through the asymmetric reduction of the 2' -ketopantothenate ester is described. Candida macedoniensis AKU 4588 was found to convert ethyl 2' -ketopantothenate (80 mg/ml) almost specifically to ethyl D-(+)-pantothenate (>98% enantiomeric excess), with a molar yield of 97.2%.
authors.affiliation: Department of Agricultural Chemistry, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kataoka
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Doi
authors.forename: H
authors.initials: H
authors.lastname: Yamada