title: Magnetic resonance spectroscopy-guided transperineal prostate biopsy and brachytherapy for recurrent prostate cancer.
abstract: Brachytherapy targeted to the peripheral zone with magnetic resonance imaging (MRI) guidance is a prostate cancer treatment option with potentially fewer complications than other treatments. Follow-up MRI when failure is suspected is, however, difficult because of radiation-induced changes. Furthermore, MR spectroscopy (MRS) is compromised by susceptibility artifacts from radioactive seeds in the peripheral zone. We report a case in which combined MRI/MRS was useful for the detection of prostate cancer in the transitional zone in patients previously treated with MR-guided brachytherapy. We propose that MRI/MRS can help detect recurrent prostate cancer, guide prostate biopsy, and help manage salvage treatment decisions.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. aszot@partners.org
authors.forename: Agnieszka Szot
authors.initials: AS
authors.lastname: Barnes
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Haker
authors.forename: Robert V
authors.initials: RV
authors.lastname: Mulkern
authors.forename: Minna
authors.initials: M
authors.lastname: So
authors.forename: Anthony V
authors.initials: AV
authors.lastname: D'Amico
authors.forename: Clare M
authors.initials: CM
authors.lastname: Tempany
mesh_terms: D001706:Biopsy / Q000379:methods; D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000532:radiotherapy*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy*