Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogs.
Three 8-week-old Miniature Smooth Haired Dachshund littermates were diagnosed with myasthenia gravis based on clinical signs, results of electrophysiological testing, and response to the short-acting anticholinesterase drug, edrophonium chloride. Congenital myasthenia gravis was confirmed by the demonstration of decreased acetylcholine-receptor density in external intercostal muscle in the absence of demonstrable serum antiacetylcholine receptor antibody or antibodies complexed to acetylcholine receptors in muscle biopsy samples. Unlike most previously reported cases of congenital myasthenia gravis that are relentlessly progressive, clinical signs resolved spontaneously by 6 months of age.
Dickinson
Peter J
PJ
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. pjdickinson@ucdavis.edu
Sturges
Beverly K
BK
Shelton
G Diane
GD
LeCouteur
Richard A
RA
D000375:Aging; D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D004285:Dogs; D004491:Edrophonium; D005260:Female; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D020294:Myasthenic Syndromes, Congenital / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000662:veterinary*; D011950:Receptors, Cholinergic / Q000378:metabolism
D011950:Receptors, Cholinergic; D004491:Edrophonium