title: Prophylactic balloon-occluded retrograde transvenous obliteration for gastric varices in compensated cirrhosis.
abstract: OBJECTIVE
  Because gastric variceal bleeding is associated with a high mortality rate, its prophylaxis is expected to improve survival. We investigated the effectiveness of balloon-occluded retrograde transvenous obliteration (B-RTO) for the treatment of gastric fundal varices.
  
  
  METHODS
  A prospective nonrandomized study was conducted. Prophylactic B-RTO was performed in 17 patients (B-RTO group), whereas the remaining 17 patients received no specific treatment (control). The nonbleeding rate, cumulative survival rate, and prognostic values of the patients were assessed.
  
  
  RESULTS
  The respective nonbleeding rates at 1, 3, and 5 years were 100%, 100%, and 83% in the B-RTO group and 81%, 59%, and 39% in the control. The respective cumulative survival rates at 1, 3, and 5 years were 94%, 85%, and 39% in the B-RTO group and 71%, 41%, and 22% in the control. Both the nonbleeding rate and the cumulative survival rate of the B-RTO group were significantly higher than those of the control (P = .01 and .04, respectively). B-RTO was determined by multivariate analysis to be a significant factor for low bleeding rate (relative risk, 0.06; 95% confidence interval [CI], 0.004-0.79), whereas B-RTO (0.11; 95% CI, 0.03-0.44) and Child-Pugh class A (0.10; 95% CI, 0.03-0.39) were the significant factors for a low mortality rate, and the presence of hepatocellular carcinoma (5.68; 95% CI, 1.49-21.7) was the significant factor for a high mortality rate.
  
  
  CONCLUSIONS
  Prophylactic B-RTO is effective in preventing gastric variceal rupture and consequently improves patient survival.
authors.affiliation: Department of Internal Medicine, National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Japan. takuma@enjoy.ne.jp
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Takuma
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nouso
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Makino
authors.forename: Syunsuke
authors.initials: S
authors.lastname: Saito
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiratori
mesh_terms: D000368:Aged; D021721:Balloon Occlusion; D004621:Embolization, Therapeutic / Q000379:methods*; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome