title: Pyoderma gangrenosum in association with juvenile rheumatoid arthritis.
abstract: A 17-year-old girl presented with multiple, painful, erythematous blisters and ulcerated lesions on the shins and buttocks. She also had arthralgia. She had suffered from juvenile rheumatoid arthritis (JRA) and received anti-inflammatory agents and oral glucocorticoids for eight years. A biopsy of a lesion showed epidermal ulceration with marked neutrophilic infiltrates in the dermis. The patient was diagnosed with pyoderma gangrenosum (PG). PG is an uncommon cutaneous ulceration within the spectrum of the neutrophilic dermatoses that is reported in association with a number of systemic disorders, including inflammatory bowel disease, hematologic disease, internal malignancies, arthritis, immune abnormalities, and solid tumors. To our knowledge, this is the first reported case of PG associated with JRA.
authors.affiliation: Department of Dermatology, Karadeniz Technical University, Medicine Faculty, Trabzon, Turkey.
authors.forename: Savaş
authors.initials: S
authors.lastname: Yayli
authors.forename: Sevgi
authors.initials: S
authors.lastname: Bahadir
authors.forename: Köksal
authors.initials: K
authors.lastname: Alpay
authors.forename: Gülseren
authors.initials: G
authors.lastname: Cimşit
authors.forename: Umit
authors.initials: U
authors.lastname: Cobanoğlu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tosun
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications*; D005260:Female; D006801:Humans; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012883:Skin Ulcer / Q000473:pathology