title: Effects of sterilization on implant mechanical property and biocompatibility.
abstract: This article concisely reviews the effects of sterilization on the mechanical properties and surface chemistries of implantable biomaterials. This article also summarizes the biological effects of the sterilization-related changes in the implant. Because there are so many different types of implant materials currently in use (including metals, polymers, and diverse biological materials), the response of tissue to these different materials varies dramatically. This review further discusses the effects of sterilization on in vivo and in vitro tissue response specifically to implantable metals and polyethylene, with the possibility of future biocompatibility testing of the implants sterilized with supercritical phase carbon dioxide sterilization.
authors.affiliation: Orthopedic Research Laboratory, Medical University of South Carolina, Charleston, SC 29425, USA. any@musc.edu
authors.forename: Y H
authors.initials: YH
authors.lastname: An
authors.forename: F I
authors.initials: FI
authors.lastname: Alvi
authors.forename: Q
authors.initials: Q
authors.lastname: Kang
authors.forename: M
authors.initials: M
authors.lastname: Laberge
authors.forename: M J
authors.initials: MJ
authors.lastname: Drews
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: M A
authors.initials: MA
authors.lastname: Matthews
authors.forename: C R
authors.initials: CR
authors.lastname: Arciola
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D006801:Humans; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D013242:Sterilization / Q000379:methods*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials