title: Association of migraine and ESR1 G325C polymorphism.
abstract: Migraine is a genetically complex disorder in which sexual hormones influence the phenotype. ESR1 G594A polymorphism has been associated with migraine in Australians. We performed a case-control study with G594A and G325C polymorphisms to determine whether ESR1 is associated with migraine in our population. An association between G594A and migraine could not be demonstrated here. By contrast, we observed that the C325 allele conferred a 1.6 (95% confidence interval=1.1-2.4) higher risk for suffering from migraine in women than the G allele. Women carrying the C352C genotype were over 3 times more likely to suffer from migraine than those carrying the G325G genotype. Therefore, we conclude that ESR1 G325C polymorphism is associated with migraine in our population.
authors.affiliation: Services of Neurology, Universitary Hospital Marqués de Valdecilla, Santander, Spain. aoterino@humv.es
authors.forename: Agustín
authors.initials: A
authors.lastname: Oterino
authors.forename: Julio
authors.initials: J
authors.lastname: Pascual
authors.forename: Carlos
authors.initials: C
authors.lastname: Ruiz de Alegría
authors.forename: Natalia
authors.initials: N
authors.lastname: Valle
authors.forename: Jesús
authors.initials: J
authors.lastname: Castillo
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Bravo
authors.forename: Félix
authors.initials: F
authors.lastname: González
authors.forename: Pablo
authors.initials: P
authors.lastname: Sánchez-Velasco
authors.forename: Amalia
authors.initials: A
authors.lastname: Cayón
authors.forename: Francisco
authors.initials: F
authors.lastname: Leyva-Cobián
authors.forename: Ana
authors.initials: A
authors.lastname: Alonso-Arranz
authors.forename: Pedro
authors.initials: P
authors.lastname: Muñoz
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D047628:Estrogen Receptor alpha