Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity.
Neuroimaging studies of painful stimuli in humans have identified a network of brain regions that is more extensive than identified previously in electrophysiological and anatomical studies of nociceptive pathways. This extensive network has been described as a pain matrix of brain regions that mediate the many interrelated aspects of conscious processing of nociceptive input such as perception, evaluation, affective response, and emotional memory. We used functional magnetic resonance imaging in healthy human subjects to distinguish brain regions required for pain sensory encoding from those required for cognitive evaluation of pain intensity. The results suggest that conscious cognitive evaluation of pain intensity in the absence of any sensory stimulation activates a network that includes bilateral anterior insular cortex/frontal operculum, dorsal lateral prefrontal cortex, bilateral medial prefrontal cortex/anterior cingulate cortex, right superior parietal cortex, inferior parietal lobule, orbital prefrontal cortex, and left occipital cortex. Increased activity common to both encoding and evaluation was observed in bilateral anterior insula/frontal operculum and medial prefrontal cortex/anterior cingulate cortex. We hypothesize that these two regions play a crucial role in bridging the encoding of pain sensation and the cognitive processing of sensory input.
Kong
Jian
J
Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA. kongj@nmr.mgh.harvard.edu
White
Nathan S
NS
Kwong
Kenneth K
KK
Vangel
Mark G
MG
Rosman
Ilana S
IS
Gracely
Richard H
RH
Gollub
Randy L
RL
D000328:Adult; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D006358:Hot Temperature; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*