title: Response of papillary renal cell carcinoma in a solitary kidney to high dose interleukin therapy.
abstract: Kidney cancer affects 36 000 Americans annually and is responsible for nearly 12 000 deaths every year in the US. Treatment with interleukin-2 (IL-2), the only FDA approved therapy for patients with advanced kidney cancer, is associated with a 10% complete response and a 12% partial response. To date, clear cell renal carcinoma has been the only histological type associated with response to IL-2-based therapy. In the current report, we describe a response to IL-2 therapy in a patient with type I papillary renal carcinoma.
authors.affiliation: Urologic Oncology Branch, CCR/NCI/NIH, Bethesda, MD, USA.
authors.forename: Eric K
authors.initials: EK
authors.lastname: Diner
authors.forename: Marston
authors.initials: M
authors.lastname: Linehan
authors.forename: McClellan
authors.initials: M
authors.lastname: Walther
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017115:Catheter Ablation; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D007376:Interleukin-2