Usefulness of neopterin levels and left ventricular function for risk assessment in survivors of acute myocardial infarction.
BACKGROUND
Results of previous studies have shown that serum neopterin levels are higher in patients with acute myocardial infarction (AMI). However, little is known regarding the prognostic value of neopterin in survivors of AMI. The present study analyzes the prognostic value of neopterin serum concentration and left ventricular ejection fraction in survivors of AMI.


METHODS
The additional prognostic information provided by neopterin to parameters of left ventricular function in survivors of AMI was investigated through 82 patients with ST-segment elevation.


RESULTS
Binary logistic regression analysis identified the following predictors of 6-month cardiac death: Killip class >I at presentation (OR=2.4, 95% CI: 1.2 to 3.8, p=0.001), a reduced ejection fraction (OR=1.9, 95% CI: 1.3 to 2.2, p=0.001), and greater neopterin (OR=1.4, 95% CI: 1.1 to 1.6, p=0.01).


CONCLUSIONS
Neopterin is associated with mortality, in addition to parameters of ventricular function (Killip class and ejection fraction) in survivors of AMI.
Dominguez-Rodriguez
Alberto
A
Abreu-Gonzalez
Pedro
P
Garcia-Gonzalez
Martín
M
D000368:Aged; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology*; D019798:Neopterin / Q000097:blood*; D012044:Regression Analysis; D018570:Risk Assessment; D017741:Survivors; D016896:Treatment Outcome; D016277:Ventricular Function, Left
D019798:Neopterin