Approach to novel functional foods for stress control 3. Establishment of stress-resistant rat model and its mechanism.
A stress-resistant rat model was introduced. SPORTS (Spontaneously-Running-Tokushima-Shikoku) rats showed significantly shorter time of immobility in the forced swim test compared to control Wister rats. Increase norepinephrine concentration secondary to decreased activity of monoamine oxidase A (MAOA) in hippocampus was observed in this model rats. This model rats are considered to be useful for studying the mechanism of psychological stress.
Nakaya
Yutaka
Y
Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
Morishima-Yamato
Masaki
M
Ishida
Kaori
K
Harada
Nagakatsu
N
Nakano
Masayuki
M
D000818:Animals; D005502:Food; D006624:Hippocampus / Q000737:chemistry / Q000201:enzymology; D023421:Models, Animal; D008995:Monoamine Oxidase / Q000032:analysis / Q000378:metabolism; D009043:Motor Activity / Q000235:genetics*; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000235:genetics* / Q000378:metabolism*; D013315:Stress, Psychological / Q000517:prevention & control*; D013550:Swimming; D013997:Time Factors
D008995:Monoamine Oxidase; D009638:Norepinephrine