title: [CPT-11-induced diarrhea treated with indisetron hydrochloride--a case report].
abstract: We report a case in which 5-HT3 receptor antagonist, indisetron hydrochloride,was effective against CPT-11-induced diarrhea. When the patient, a 63-year-old male, developed lymph node metastases after resection for primary gastric cancer, 24-hour continuous administration of CPT-11 (125 mg/m2) was initiated. The following day he had diarrhea, possibly associated with the CPT-11. Hange-shashinto was administered but did not improve the condition. Thereafter, the diarrhea followed a protracted course (grade 1 to 2). His diarrhea improved when indisetron hydrochloride was administered with the fifth course of chemotherapy in place of the usual antiemetic drug. In this patient, indisetron hydrochloride, in addition to its role as an antiemetic, was considered to be effective against CPT-11-induced diarrhea.
authors.affiliation: Dept. of Internal Medicine, Senseki Hospital.
authors.forename: Mariko
authors.initials: M
authors.lastname: Kanbe
authors.forename: Motonobu
authors.initials: M
authors.lastname: Osada
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives*; D003967:Diarrhea / Q000139:chemically induced* / Q000188:drug therapy*; D004334:Drug Administration Schedule; D006801:Humans; D000077146:Irinotecan; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000627:therapeutic use*; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D011720:Pyrazoles; C500220:indisetron hydrochloride; D000077146:Irinotecan; D002166:Camptothecin