Antimicrobial resistance data on 16,756 Streptococcus pneumoniae isolates in 1999: A Pan-Regional Multicenter Surveillance Study in France.
The rising prevalence of antibiotic-resistant Streptococcus pneumoniae is a phenomenon observed to different degrees around the world. The present national surveillance study report analyzes a total of 16,756 strains of S. pneumoniae collected across France in 1999. The overall prevalence of S. pneumoniae with decreased susceptibility to penicillin was 44%, to amoxicillin 26%, and to cefotaxime 17%. The proportion of high-level resistant strains to penicillin (MIC > 1 mg/L), amoxicillin and cefotaxime (MIC > 2 mg/L) remained low: 12.3%, 1.8%, and 0.4% respectively. Prevalence of resistance to other antibiotics was high: 53% to erythromycin, 41.7% to cotrimoxazole, 31.8% to tetracycline, and 24.6% to chloramphenicol. Prevalence of penicillin-resistant S. pneumoniae varied according to subject age and specimen source. It was higher in children (52.7%) than in adults (39.8%) and higher in strains isolated from middle ear fluid (63.6%) than from blood cultures (41.8%) in children. S. pneumoniae resistant to other antibiotics were more common in children than in adults, although figures showed geographical variations. Comparison with a previous study realized in 1997 in the same regions confirms a rising trend in the prevalence of resistant bacteria. Therefore, we conclude that prevalence of antibiotic-resistant S. pneumoniae in 1999 continued to rise in France, although strains with high-level resistance to penicillin remained stable.
Demachy
Marie-Claude
MC
CH Meaux, France.
Vernet-Garnier
Véronique
V
Cottin
Jeanne
J
Cattier
Blandine
B
Chardon
Hubert
H
Chomarat
Monique
M
Dupont
Philippe
P
Fauchere
Jean-Louis
JL
Fosse
Thierry
T
Laaberki
Marie-France
MF
Laurans
Geneviève
G
Lemozy
Jacqueline
J
Maugein
Jeanne
J
Murbach
Valérie
V
Pechinot
André
A
Romaszko
Jean Pierre
JP
Roussel-Delvallez
Micheline
M
Thoreux
Pierre-Henri
PH
Vaucel
Jacques
J
Vergnaud
Michel
M
Weber
Michèle
M
Ploy
Marie-Cécile
MC
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D005602:France; D006801:Humans; D011159:Population Surveillance; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents