title: Meeting the challenge of chronic ischaemic heart disease with trimetazidine.
abstract: The risk of cardiovascular events in patients with diabetes is similar to that of patients with previous history of ischaemic heart disease and the prevalence of ischaemic heart disease complicating diabetic syndromes is growing rapidly. Management of ischaemic heart disease in diabetic patients remains a challenge. Therapeutic options include several antianginal agents, and mechanical removal of coronary obstructions by percutaneous transluminal coronary angioplasty, and aorto-coronary by-pass surgery. Unfortunately, all treatments are less effective in diabetic patients than in nondiabetic patients. Direct modulation of cardiac metabolic alterations associated with the diabetic syndrome appears as a promising alternative for the management of ischaemic heart disease in diabetic patients. Results obtained in anginal patients with the metabolic agent trimetazidine are consistent with this hypothesis.
authors.affiliation: Postgraduate School of Cardiology, University of Siena, Italy. marzilli@unisi.it
authors.forename: Mario
authors.initials: M
authors.lastname: Marzilli
authors.forename: Silvia
authors.initials: S
authors.lastname: Affinito
mesh_terms: D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D014292:Trimetazidine