Anti-inflammatory activity of Bacopa monniera in rodents.
The ethanol extract of Bacopa monniera (Scrophulariaceae) exhibited marked anti-inflammatory activity against carrageenan-induced paw edema in mice and rats, an acute inflammatory model. To assess the possible mechanism of anti-inflammatory action against carrageenan, the ethanol extract was treated with chemical mediators (histamine, serotonin, bradykinin, prostaglandin E(2) and arachidonic acid)-induced edema in rats. The extract selectively inhibited prostaglandin E(2)-induced inflammation. Thus, it may be inferred that B. monniera possesses significant anti-inflammatory activity that may well be relevant for its effectiveness in the healing of various inflammatory conditions in traditional medicine.
Channa
Shabana
S
Department of Pharmacology and Therapeutics, Frontier Medical College, Abbottabad, Pakistan. shabanachanna@hotmail.com
Dar
Ahsana
A
Anjum
Shazia
S
Yaqoob
Muhammad
M
Atta-Ur-Rahman
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D034681:Bacopa; D004487:Edema / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts