Antimicrobial resistance of Staphylococcus aureus and oral streptococci strains from high-risk endocarditis patients.
This study sought to determine the antimicrobial susceptibility of Staphylcoccus aureus and viridans group streptococci strains collected from the forearm skin and saliva of 30 patients at high risk of endocarditis. Agar susceptibility tests of antibiotics routinely utilized in dentistry were used to verify antimicrobial resistance of bacterial strains. Of the Staphylcoccus aureus strains, 50% were resistant to ampicillin, 53.3% to amoxicillin, 60.0% to penicillin G, 13.3% to amoxicillin/clavulanate, 20.0% to azithromycin, 27.6% to clarithromycin, 23.3% to erythromycin, 3.3% to cefazolin, and 6.7% to clindamycin. Regarding streptococci, 16.7% of the strains were resistant to ampicillin, 16.7% to amoxicillin, 23.3% to azithromycin, 23.3% to clarithromycin, 30.0% to erythromycin, 13.3% to cefazolin, 26.7% to clindamycin, 16.7% to penicillin G, and 3.3% to amoxicillin/clavulanate. Pathogens associated with bacterial endocarditis exhibited elevated resistance rates against the antibiotics used for prophylaxis in dentistry.
Groppo
Francisco Carlos
FC
Department of Physiological Sciences, Dentistry School of Piracicaba, UNICAMP, Brazil.
Castro
Flavia Meira
FM
Pacheco
Aline Barros
AB
Motta
Rogerio Heladio
RH
Filho
Thales Rocha de Mattos
TR
Ramacciato
Juliana Cama
JC
Florio
Flavia Martao
FM
Meechan
John Gerard
JG
D000368:Aged; D000658:Amoxicillin / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017963:Azithromycin / Q000494:pharmacology; D002437:Cefazolin / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004198:Disease Susceptibility; D024881:Drug Resistance, Bacterial; D004697:Endocarditis, Bacterial / Q000503:physiopathology*; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010400:Penicillin G / Q000494:pharmacology; D012307:Risk Factors; D012463:Saliva / Q000382:microbiology*; D012867:Skin / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D034363:Viridans Streptococci / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin; D000658:Amoxicillin; D017963:Azithromycin; D017291:Clarithromycin; D002437:Cefazolin; D010400:Penicillin G