Dysfunction of lamin A triggers a DNA damage response and cellular senescence.
In higher eukaryotes, the nuclear lamins play an important role in maintaining the integrity of the nuclear envelope and the nucleus itself. Two recent papers show that a mutation that affects the processing of one of the nuclear lamins, lamin A, results in increased sensitivity to DNA damaging agents, an elevated DNA damage response, and a senescent phenotype. These studies underscore the role of the nuclear envelope in maintaining genomic stability and the interplay between nuclear architecture and the DNA damage response.
Lees-Miller
Susan P
SP
Department of Biochemistry & Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alta., Canada T2N 4N1. leesmill@ucalgary.ca
D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D016922:Cellular Senescence; D004249:DNA Damage; D006801:Humans; D034904:Lamin Type A / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D034882:Lamins / Q000378:metabolism; D009154:Mutation; D009685:Nuclear Envelope / Q000378:metabolism; D034881:Nuclear Lamina / Q000378:metabolism; D015530:Nuclear Matrix / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010641:Phenotype
D034904:Lamin Type A; D034882:Lamins; D009687:Nuclear Proteins