Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.
Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-gamma secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-gamma production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.
Aldemir
Hatice
H
Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique/Université de Nice-Sophia Antipolis Unité Mixte de Recherche 6097, Sophia Antipolis, France.
Prod'homme
Virginie
V
Dumaurier
Marie-Jeanne
MJ
Retiere
Christelle
C
Poupon
Gwenola
G
Cazareth
Julie
J
Bihl
Franck
F
Braud
Veronique M
VM
D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D017252:CD3 Complex / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism* / Q000502:physiology*; D008024:Ligands; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism
D000954:Antigens, Surface; D017252:CD3 Complex; C400041:CLEC2D protein, human; C527203:KLRB1 protein, human; D037181:Lectins, C-Type; D008024:Ligands; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D007371:Interferon-gamma