title: Epithelial-myoepithelial carcinoma in the base of the tongue: a case report.
abstract: OBJECTIVE
  To report a rare case of epithelial-myoepithelial carcinoma (EMC) of a minor salivary gland originating in the base of the tongue, which is a highly unusual location.
  
  
  METHODS
  This is a case report and a review of literature.
  
  
  METHODS
  A 76-year-old man was referred to our outpatient clinic with a 6-month history of a sensation of a foreign body in the pharynx. Endoscopic examination revealed a tumorous lesion 40 x 20 mm in the base of the tongue on the left side. A biopsy was performed, and the lesion was histologically identified as squamous cell carcinoma.
  
  
  RESULTS
  The patient underwent subtotal glossectomy, bilateral neck dissection, and reconstruction with a microvascularized rectus abdominis myocutaneous flap. The final diagnosis based on the histological and immunohistochemical findings was EMC. Because neither histological evidence of residual tumor in the surgical margin nor neck metastases were found, radiotherapy was not performed. No local recurrence or distant metastases have been found 19 months post-surgery.
  
  
  CONCLUSIONS
  We believe this report is the first description of EMC originating in the base of the tongue. We conclude that a wide surgical excision with a clear margin and close, prolonged follow-up are recommended for the treatment of EMC.
authors.affiliation: Department of Otolaryngology, Head, and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto, Japan. 035r5120@med.stud.kumamoto-u.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kumai
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ogata
authors.forename: Eiji
authors.initials: E
authors.lastname: Yumoto
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009208:Myoepithelioma / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D019647:Oral Surgical Procedures / Q000379:methods; D018570:Risk Assessment; D014062:Tongue Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome