title: Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.
abstract: Charge delocalization (6+ to 8+) in "noncovalent" linear trinuclear platinum complexes produces compounds with cytotoxicity in some cases equivalent to cisplatin. The cellular uptake of a novel 8+ compound is greater than that of neutral cisplatin as well as other multinuclear Pt compounds.
authors.affiliation: Chemistry Department, Virginia Commonwealth University, 1001 W. Main Street, Richmond, Virginia 23284-2006, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Harris
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yang
authors.forename: Alex
authors.initials: A
authors.lastname: Hegmans
authors.forename: Lawrence
authors.initials: L
authors.lastname: Povirk
authors.forename: John J
authors.initials: JJ
authors.lastname: Ryan
authors.forename: Lloyd
authors.initials: L
authors.lastname: Kelland
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Farrell
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*
chemical_list: D017671:Platinum Compounds