title: Hemodynamic effects of sildenafil citrate (Viagra) on segmental branches of bilateral renal arteries.
abstract: BACKGROUND
  Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED.
  
  
  METHODS
  Total of 35 male patients aging between 34 and 56 years were recruited into study. Patients were evaluated with renal color Doppler sonography (CDS) before and after (45-75 min) peroral sildenafil citrate (50 mg) administration. Peak systolic flow rate (V(max)), end diastolic flow rate (V(min)), resistive index (RI) and pulsatility index (PI) of renal artery segmental branches were determined before and after sildenafil citrate administration.
  
  
  RESULTS
  V(min) measured at right lower segment was significantly reduced after sildenafil administration (p = 0.030). Accordingly mean RI and PI of right lower segment of renal artery slightly increased after drug administration (p = 0.007 and p = 0.012, respectively). The measurements on other segments had no significant change after sildenafil treatment when compared to baseline values. On this single dose administration no side effect was recorded.
  
  
  CONCLUSIONS
  Findings of the present study demonstrated that peroral sildenafil citrate usage had slight effects on hemodynamic parameters of lower segmental branch of right renal artery. This result could not be interpreted as robust evidence for hemodynamic changes of renal arteries associated with sildenafil usage nevertheless warrants more comprehensive research with larger number of patients.
authors.affiliation: Department of Urology, Firat University, Elazig, Turkey. drarslan@yahoo.com
authors.forename: Arslan
authors.initials: A
authors.lastname: Ardicoglu
authors.forename: Ercan
authors.initials: E
authors.lastname: Kocakoc
authors.forename: Veysel
authors.initials: V
authors.lastname: Yuzgec
authors.forename: Zulkif
authors.initials: Z
authors.lastname: Bozgeyik
authors.forename: Halit
authors.initials: H
authors.lastname: Canatan
authors.forename: Adem
authors.initials: A
authors.lastname: Kiris
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology*; D000068677:Sildenafil Citrate; D013450:Sulfones; D018615:Ultrasonography, Doppler, Color; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate