title: Free fatty acid concentrations in gallbladder bile collected from Chilean patients with gallstones.
abstract: OBJECTIVE
  To evaluate the association between gallstones and biliary free fatty acids (FFAs) as the first attempt to clarify whether biliary FFAs relate to developing gallbladder cancer (GBC) in Chile, which has the highest mortality rate in the world.
  
  
  METHODS
  Gallbladder bile from 21 male and 129 female patients with gallstones from Santiago was collected, and their FFAs were measured. The results were compared with those observed in a similar previous study performed in Niigata and Kochi Prefectures which showed the highest and lowest mortality rates, respectively, for GBC in Japan.
  
  
  RESULTS
  Palmitoleic and linolenic acids compositions in Santiago patients were significantly lower than those in Niigata and Kochi patients, though these compositions in Niigata patients were significantly lower than those in Kochi patients. The levels of these FFAs compositions decreased in the order of Kochi, Niigata, and Santiago patients.
  
  
  CONCLUSIONS
  Decreased biliary FFAs compositions may relate to developing gallstones and subsequently GBC.
authors.affiliation: Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan. troof@med.niigata-u.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Iván
authors.initials: I
authors.lastname: Serra
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hori
authors.forename: Alfonso
authors.initials: A
authors.lastname: Calvo
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Villegas
authors.forename: Norio
authors.initials: N
authors.lastname: Shibuya
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masaharu
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001646:Bile / Q000378:metabolism*; D002677:Chile; D002851:Chromatography, High Pressure Liquid; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005260:Female; D042882:Gallstones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005230:Fatty Acids, Nonesterified