title: Two full-term pregnancies in a patient with mitochondrial myopathy and chronic ventilatory insufficiency.
abstract: Mitochondrial myopathies are a group of diseases characterized by metabolic defects at the mitochondrial respiratory chain level which result in impaired oxidative phosphorylation and ATP synthesis. As with other neuromuscular diseases, respiratory muscles can be affected and ventilatory failure may occur. There have been isolated case reports of pregnant patients with ventilatory failure due to neuromuscular diseases such as polio and spinal muscular atrophy. We describe the case of a 34-year-old patient with mitochondrial myopathy and ventilatory failure requiring non-invasive ventilation who carried two pregnancies to term with no complications. We have not found a similar case in the literature.
authors.affiliation: Servicio de Neumologia, Hospital Universitario La Paz, Madrid, Spain. sdl01@nacom.es
authors.forename: Salvador
authors.initials: S
authors.lastname: Díaz-Lobato
authors.forename: Maria A
authors.initials: MA
authors.lastname: Gómez Mendieta
authors.forename: María S
authors.initials: MS
authors.lastname: Moreno García
authors.forename: Sagrario
authors.initials: S
authors.lastname: Mayoralas-Alises
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Arpa Gutierrez
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017240:Mitochondrial Myopathies / Q000503:physiopathology*; D011247:Pregnancy; D018566:Pregnancy, High-Risk / Q000502:physiology*; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000503:physiopathology*