title: Comparison of family histories in FTLD subtypes and related tauopathies.
abstract: Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks.
authors.affiliation: Memory and Aging Center, University of California, San Francisco, CA 94117, USA. jgoldman@memory.ucsf.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Goldman
authors.forename: J M
authors.initials: JM
authors.lastname: Farmer
authors.forename: E M
authors.initials: EM
authors.lastname: Wood
authors.forename: J K
authors.initials: JK
authors.lastname: Johnson
authors.forename: A
authors.initials: A
authors.lastname: Boxer
authors.forename: J
authors.initials: J
authors.lastname: Neuhaus
authors.forename: C
authors.initials: C
authors.lastname: Lomen-Hoerth
authors.forename: K C
authors.initials: KC
authors.lastname: Wilhelmsen
authors.forename: V M-Y
authors.initials: VM
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Grossman
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000235:genetics; D018888:Aphasia, Primary Progressive / Q000235:genetics; D025063:Chromosome Disorders / Q000235:genetics; D015331:Cohort Studies; D003704:Dementia / Q000235:genetics*; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D012189:Retrospective Studies; D013494:Supranuclear Palsy, Progressive / Q000235:genetics; D024801:Tauopathies / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics
chemical_list: D016875:tau Proteins