The small peptide-catalyzed direct asymmetric aldol reaction in water.
Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding beta-hydroxy ketones with up to 86% ee in water and 99% ee in aqueous media.
Dziedzic
Pawel
P
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Zou
Weibiao
W
Háfren
Jonas
J
Córdova
Armando
A
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D014867:Water
D000447:Aldehydes; D007659:Ketones; D009842:Oligopeptides; D014867:Water