title: Multiscale analysis of the coupled effects governing the movement of interstitial fluid in cortical bone.
abstract: A multiscale approach (periodic homogenization) is carried out to model osteon's behaviour, and especially the coupled phenomena that govern its interstitial fluid movement. Actions of electro-osmotic and osmotic motions in addition to the classical Poiseuille flow are studied at the mesoscale of the canaliculus and within the micropores of the collagen-apatite matrix. Use of this fully coupled modelling leads to a comparison of these different effects. Limitation of a classical Darcian description of the fluid flow at the two scales is so studied. For each of these studies a special attention is given to the pore's geometry influence and to their electrical and hydraulic properties.
authors.affiliation: Laboratoire de Mécanique Physique, CNRS UMR 7052 B2OA Faculté des Sciences et Technologie, Université Paris XII-Val de Marne, 61, Avenue du Général de Gaulle, 94010 Créteil Cédex, France. lemaire@univ-paris12.fr
authors.forename: Thibault
authors.initials: T
authors.lastname: Lemaire
authors.forename: Salah
authors.initials: S
authors.lastname: Naïli
authors.forename: Agnès
authors.initials: A
authors.lastname: Rémond
mesh_terms: D001671:Biochemistry / Q000379:methods; D001692:Biological Transport; D001696:Biomechanical Phenomena / Q000379:methods*; D001703:Biophysics / Q000379:methods; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000473:pathology; D004573:Electrolytes; D004594:Electrophysiology; D006801:Humans; D007477:Ions; D015233:Models, Statistical; D008962:Models, Theoretical; D009997:Osmotic Pressure; D016012:Poisson Distribution; D016062:Porosity; D011312:Pressure; D055672:Static Electricity
chemical_list: D004573:Electrolytes; D007477:Ions