Metalloporphyrin-NO bonding: building bridges with organometallic chemistry.
DFT calculations in our laboratory and elsewhere have elucidated fundamental aspects of the structure and bonding of a variety of metalloporphyrin-diatomic complexes, including the biologically important heme CO, NO, and O(2) complexes. We have also studied some more exotic species such as metalloporphyrin-dinitrosyl, -dialkyl, and -diaryl complexes. In the course of this research, we discovered a number of unexpected similarities (isolobal analogies) between the bonding in metalloporphyrin-NO and organometallic compounds. Equally important, DFT calculations have played a significant role in advancing our understanding of selective diatomic ligand binding by heme proteins.
Ghosh
Abhik
A
Department of Chemistry, University of Tromsø, Norway. abhik@chem.uit.no
D006420:Hemeproteins / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
D006420:Hemeproteins; D008665:Metalloporphyrins; D009942:Organometallic Compounds; D009569:Nitric Oxide