title: Childhood granulomatous periorificial dermatitis: a controversial disease.
abstract: The etiology, diagnosis and treatment of childhood granulomatous periorificial dermatitis (GPD) are highly controversial. Some authors underline the similarities between GPD and perioral dermatitis and consider both as part of a spectrum while other authors regard GPD as a distinctive condition. Clinically GPD is a papulo-pustular periorificial disease of the face which histopathologically shows a granulomatous perifollicular infiltrate. Because of its granulomatous pattern, GPD also has been related to cutaneous sarcoidosis. The clinical course is benign and self-limited. Topical steroids are regarded as either the main cause or a worsening factor. While topical treatment is occasionally effective, systemic antibiotic therapy of GPD is usually recommended. We report a "typical" case of GPD and review the literature to discuss the difficulties in its diagnosis and treatment.
authors.affiliation: Department of Dermatology, Medical University of Graz, Austria. iris.zalaudek@meduni-graz.at
authors.forename: Iris
authors.initials: I
authors.lastname: Zalaudek
authors.forename: Alessandro
authors.initials: A
authors.lastname: Di Stefani
authors.forename: Gerardo
authors.initials: G
authors.lastname: Ferrara
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000188:drug therapy; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D051261:Granulomatosis, Orofacial / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D006854:Hydrocortisone