Synthesis, physicochemical and pharmacokinetic characterization of calcium uronates.
Four calcium compounds containing uronic acids (D(+)-galacturonic and D(+)-glucuronic) in L:M ratio = 2 and 3 were isolated by applying novel (except for one complex) synthetic procedures. The compounds were characterized by elemental analysis, spectroscopic methods (diffuse reflectance and absorption UV-visible, IR, FIR), mass spectrometry, fast atom bombardment (FAB), thermal decomposition, thermogravimetry/derivative thermogravimetry (TG/DTG) data and differential scanning calorimetric studies (DSC). Two modes of water binding in the complexes, i.e., hydration and coordination-like, were established. Computer-aided analysis has shown that further investigations are needed in order to determine the applicability of calcium uronates as calcium carriers.
Kmiecik
Sylwia
S
Institute of Inorganic Chemistry and Metallurgy of Rare Elements, Faculty of Chemistry, University of Technology, Wybrzee wyspianskiego 27, 50-370 Wrocław, Poland.
Maciejewska
Gabriela
G
Adach
Anna
A
Grabowski
Tomasz
T
Gulanowski
Bogdan
B
Cieślak-Golonka
Maria
M
D002118:Calcium / Q000737:chemistry* / Q000493:pharmacokinetics; D004055:Differential Thermal Analysis; D020723:Glucuronic Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000737:chemistry* / Q000493:pharmacokinetics; D007700:Kinetics; D013058:Mass Spectrometry; D011188:Potassium / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry
D006603:Hexuronic Acids; C007819:galacturonic acid; D020723:Glucuronic Acid; D011188:Potassium; D002118:Calcium