title: [Salvage surgery after failure of radiotherapy in laryngeal cancer].
abstract: OBJECTIVE
  Efficacy of salvage surgery after radiotherapy failure in patients with laryngeal cancer.
  
  
  METHODS
  Retrospective analysis of 121 patients treated in our clinic between 1980 and 2003 (supraglottis--86 patients, glottis--35). In 70% of patients T-stage was T3 and T4 and regional metastases were present in 56% of cases. We performed statistical analysis of recurrence rates and 5-years survival according to Kaplan-Meier method.
  
  
  RESULTS
  Glottic localization (p = 0.02) and extracapsular spread (p = 0.03) were significant factors of final outcome. Local and regional stage was not significant factor of recurrence. Disease free 5-year survival was 53%.
  
  
  CONCLUSIONS
  Salvage surgery is a reasonable method that could save about 50% of patients after radiotherapy failure.
authors.affiliation: Klinika Otolaryngologii CMKP, Wojewbdzki Szpital Bródnowski, Warszawie.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lazecka
authors.forename: Antoni
authors.initials: A
authors.lastname: Osmólski
authors.forename: Robert
authors.initials: R
authors.lastname: Osmólski
authors.forename: Zofia
authors.initials: Z
authors.lastname: Frenkiel
authors.forename: Bartosz
authors.initials: B
authors.lastname: Wachulski
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000601:surgery*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods; D016019:Survival Analysis; D017211:Treatment Failure