Arp2/3 and SCAR: plants move to the fore.
The actin-nucleating Arp2/3 complex is essential for life in yeast and animals, but not in plants, in which mutants of Arp2/3 complex components show relatively minor developmental abnormalities. Animal cells control the activity of the Arp2/3 complex through the suppressor of cyclic AMP receptor (SCAR) complex to achieve cell motility. Amazingly, plants have also retained the SCAR cell-motility pathway, and now provide a unique model for the study of new aspects of SCAR function in the absence of cell motility.
Deeks
Michael J
MJ
The Integrative Cell Biology Laboratory, School of Biological and Biomedical Sciences, University of Durham, South Road, Durham, DH1 3LE, UK.
Hussey
Patrick J
PJ
D051376:Actin-Related Protein 2-3 Complex / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D063245:Plant Development; D010944:Plants / Q000378:metabolism; D015800:Protozoan Proteins / Q000502:physiology*; D015398:Signal Transduction; D015003:Yeasts / Q000254:growth & development
D051376:Actin-Related Protein 2-3 Complex; D015800:Protozoan Proteins; C491975:SCAR protein, Dictyostelium