title: Monitoring the fluidized bed granulation process based on S-statistic analysis of a pressure time series.
abstract: Pressure fluctuation measurements collected during the fluidized bed granulation of pharmaceutical granule have been analyzed using the attractor comparison technique denoted as the S-statistic. Divergence of the bed state from the reference during granulation is followed by a return to a condition statistically similar to the original state of the dry fluidized ingredients on drying. This suggests insensitivity of the S-statistic technique to the changes in particle size distribution occurring during the granulation process. Consequently, the monitoring of pressure fluctuations alone may provide an easily implemented technique for the tracking of granule moisture and process end-point determination.
authors.affiliation: Department of Chemical Engineering, The University of Saskatchewan, Saskatchewan, Saskatoon, Canada S7N 5C5.
authors.forename: Gareth
authors.initials: G
authors.lastname: Chaplin
authors.forename: Todd
authors.initials: T
authors.lastname: Pugsley
authors.forename: Conrad
authors.initials: C
authors.lastname: Winters
mesh_terms: D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D011312:Pressure; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000706:statistics & numerical data*; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations