Neovascularization and cardiac repair by bone marrow-derived stem cells.
Postinfarction congestive heart failure with impaired systolic left ventricular function is a loss of cardiomyocyte disease. Adult stem or progenitor cells from the bone marrow and the peripheral blood have been experimentally shown to differentiate towards endothelial cells and cardiomyocytes under the appropriate conditions. The use of autologous adult stem cells for neovascularization and cardiac regeneration is a promising concept and has shown benefit in pilot clinical trails enrolling postinfarction patients with coronary artery disease. Cell therapy may act through differentiation into and thus replacement of cardiomyocytes and/or neovascularization, the formation of new vessels in the adult organism. Moreover, the release of factors acting in a paracrine manner may contribute to neovascularization and scar remodelling. In this review, the experimental data regarding neovascularization and cardiomyocyte formation from adult stem/progenitor cells are discussed.
Badorff
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Department of Molecular Cardiology, University of Frankfurt, Theodor Stern-Kai 7, 60590 Frankfurt, Germany.
Dimmeler
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S
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000473:pathology* / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*