title: Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.
abstract: By comparing mammalian genomes, we and others have identified actively transcribed Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences and insertion sites. To elucidate the functions of evolutionarily conserved retrotransposon-derived genes in mammalian development, we produced mice that lack one of these genes, Peg10 (paternally expressed 10), which is a paternally expressed imprinted gene on mouse proximal chromosome 6. The Peg10 knockout mice showed early embryonic lethality owing to defects in the placenta. This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development.
authors.affiliation: Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ono
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kimiko
authors.initials: K
authors.lastname: Inoue
authors.forename: Mie
authors.initials: M
authors.lastname: Naruse
authors.forename: Takako
authors.initials: T
authors.lastname: Usami
authors.forename: Noriko
authors.initials: N
authors.lastname: Wakisaka-Saito
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hino
authors.forename: Rika
authors.initials: R
authors.lastname: Suzuki-Migishima
authors.forename: Narumi
authors.initials: N
authors.lastname: Ogonuki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Miki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohda
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ogura
authors.forename: Minesuke
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kaneko-Ishino
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Ishino
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins; D019175:DNA Methylation; D004268:DNA-Binding Proteins; D020964:Embryo Loss / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D051379:Mice; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D010312:Parthenogenesis / Q000235:genetics; D010920:Placenta / Q000473:pathology* / Q000502:physiology; D011247:Pregnancy; D016601:RNA-Binding Proteins; D018626:Retroelements; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C110780:Peg10 protein, mouse; D016601:RNA-Binding Proteins; D018626:Retroelements; D014157:Transcription Factors