High rates of erythromycin and clindamycin resistance among OBGYN isolates of group B Streptococcus.
In vitro susceptibility testing on 200 Streptococcus agalactiae strains isolated during a 4-year period from vaginal/rectal specimens demonstrated a very high resistance rate for both erythromycin (54%) and clindamycin (33%). Methylase genes erm(B) and erm(TR) and efflux genes mef(E) and mef(A) were detected. Pulsed-field gel electrophoresis showed evidence of both clonal spread and multiclonal dissemination of resistant strains. All but 3 of 200 isolates were susceptible to telithromycin.
DiPersio
Linda P
LP
Falor Division of Surgical Research, Summa Health System, Akron, OH 44304, USA. dipersij@summa-health.org
DiPersio
Joseph R
JR
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D002981:Clindamycin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008780:Methyltransferases / Q000235:genetics; D009775:Obstetrics and Gynecology Department, Hospital; D012007:Rectum / Q000382:microbiology; D013290:Streptococcal Infections / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000235:genetics; D014621:Vagina / Q000382:microbiology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002981:Clindamycin; D004917:Erythromycin; D008780:Methyltransferases; C431709:ErmA protein, Bacteria