Neurophysiological patterns of vegetative and minimally conscious states.
This paper reviews the possible usefulness of electroencephalogram (EEG) and evoked potential (EP) recording in vegetative and poorly-responsive patients. There is a marked inter-individual EEG and EP variability, which reflects the state heterogeneity. Four clinical applications are described: (1) the identification of primary midbrain dysfunction--and, therefore, a possible reversibility--in post-traumatic states; (2) the identification of the permeability of sensory channels; (3) quantitative follow-up; and (4) individual assessment of cognitive functions and/or consciousness. Regarding this last issue, the loss of primary cortical EPs, although rarely observed, constitutes one major argument against consciousness. Conversely, cognitive EPs definitely proved the persistence of cognitive functions in several vegetative patients. Whether these cognitive functions are conscious or not remains a matter of debate.
Guérit
Jean-Michel
JM
St Luc Hospital, Catholic University of Louvain, and CHIREC, Brussels, Belgium. jm.guerit@chirec.be
D000208:Acute Disease; D001933:Brain Stem / Q000503:physiopathology; D002908:Chronic Disease; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D018450:Disease Progression; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009482:Neurophysiology / Q000379:methods*; D018458:Persistent Vegetative State / Q000150:complications* / Q000503:physiopathology; D012660:Semantics