title: Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder.
abstract: The zinc metalloenzyme glyoxalase I (GLO1) is thought to play a role in anxiety disorders because a reduced brain expression of GLO1 has been associated with increased anxiety-behaviours in mice. Recently, a functional Ala111Glu polymorphism in GLO1 has been shown to result in a reduced enzyme activity. The present study tested the hypothesis that this common genetic variant could confer susceptibility to panic disorder using an Italian population sample of 162 panic disorder patients and 288 matched controls. Statistical analysis failed to show association with the overall diagnosis of the disease. However, a weak but significant association was demonstrated between this polymorphism and panic disorder without agoraphobia. While our data suggest that this polymorphism is unlikely to have a major function in the pathogenesis of panic disorder, it could play a role in the subgroup of patients without agoraphobic avoidance.
authors.affiliation: Department of Applied Health and Behavioural Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, I-27100, Pavia, Italy. pierluigi.politi@unipv.it
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Politi
authors.forename: Piercarlo
authors.initials: P
authors.lastname: Minoretti
authors.forename: Colomba
authors.initials: C
authors.lastname: Falcone
authors.forename: Valentina
authors.initials: V
authors.lastname: Martinelli
authors.forename: Enzo
authors.initials: E
authors.lastname: Emanuele
mesh_terms: D000328:Adult; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008297:Male; D016584:Panic Disorder / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D007791:Lactoylglutathione Lyase