title: Diabetes mellitus and antipsychotic treatment in the United Kingdom.
abstract: OBJECTIVE
  Treatment-emergent diabetes has been reported during exposure to conventional and atypical antipsychotics. This retrospective cohort study explored the UK General Practice Research Database (GPRD) to determine hazard ratios of diabetes for patients prescribed antipsychotics.
  
  
  METHODS
  A Cox proportional hazard regression model using age, gender, and obesity (BMI > 30 kg/m2) was used to determine the hazard ratio (HR) of diabetes development in conventional antipsychotic (N = 59,089), atypical antipsychotic (N = 9053), individual antipsychotic, and general patient population cohorts (N = 1,491,548).
  
  
  RESULTS
  Compared with the general GPRD patient population, patients exposed to conventional or atypical antipsychotics had a higher risk of developing diabetes (atypical antipsychotic cohort: HR = 2.9, CI = 2.0-4.4; and conventional antipsychotic cohort: HR = 1.9, CI = 1.6-2.3). The risk of developing diabetes during thioridazine, risperidone, or olanzapine treatment was significantly higher compared with the general GPRD patient population.
  
  
  CONCLUSIONS
  Consistent with other epidemiology studies, this study supports an increased risk of developing diabetes during treatment with antipsychotics.
authors.affiliation: Eli Lilly and Company, Indianapolis, IN, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Carlson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hornbuckle
authors.forename: Frank
authors.initials: F
authors.lastname: DeLisle
authors.forename: Ludmila
authors.initials: L
authors.lastname: Kryzhanovskaya
authors.forename: Alan
authors.initials: A
authors.lastname: Breier
authors.forename: Patrizia
authors.initials: P
authors.lastname: Cavazzoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D015992:Body Mass Index; D015331:Cohort Studies; D016208:Databases, Factual; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D012306:Risk; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D014150:Antipsychotic Agents