title: Striatal dopamine D2/D3 receptor availability in male smokers.
abstract: It has been reported that the activation of the nicotine receptor evokes central endogenous dopamine release. However, whether smoking affects striatal dopamine D(2)/D(3) availability over the long run has not been well established in vivo. Fifteen male smokers and their matching controls were recruited. Striatal dopamine D(2)/D(3) receptor availability was assessed by single photon emission computed tomography with [(123)]IBZM Iodo-benzaimide. There was no significant difference in striatal D(2)/D(3) receptor availability between smokers and controls.
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, Tainan 704, Taiwan. ykyang@mail.ncku.edu.tw
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Wei Jen
authors.initials: WJ
authors.lastname: Yao
authors.forename: Joseph P
authors.initials: JP
authors.lastname: McEvoy
authors.forename: Ching Lin
authors.initials: CL
authors.lastname: Chu
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: Nan Tsing
authors.initials: NT
authors.lastname: Chiu
mesh_terms: D000328:Adult; D001549:Benzamides; D003287:Contrast Media; D003342:Corpus Striatum / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism*
chemical_list: D001549:Benzamides; D003287:Contrast Media; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide