Viral persistence: parameters, mechanisms and future predictions.
For a virus to persist, it must actively curtail the host's antiviral immune response. Here, we review the conceptual basis by which this can occur and discuss the subsequent fate of differentiated cells infected over long periods of time. We also consider how the compromised antiviral immune response can be revigorated or replaced with a potent response that purges the virus and thereby terminates persistent infection.
Oldstone
Michael B A
MB
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. mbaobo@scripps.edu
D000818:Animals; D001117:Arenaviridae Infections / Q000276:immunology / Q000821:virology*; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D008217:Lymphocytic choriomeningitis virus / Q000502:physiology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D017735:Virus Latency / Q000276:immunology*