title: A case of Werner syndrome with three primary lesions of malignant melanoma.
abstract: Three primary lesions of malignant melanoma developed in a 44-year-old Japanese woman with Werner syndrome. One lesion was on the right large pudental lip and the others in distinct locations on her left sole. After the wide local excision of these tumors, the wound of the large pudental lip was sutured, and the defects on the sole were covered with skin grafts. After one course of chemotherapy consisting of dacarbazine, nimustine, vincristine sulfate and local injection of Interferon beta were performed, severe myelosupression occurred and continued for two months. Defective production of WRN protein was confirmed by Western blotting, although the three representative mutations in Japanese patients, mutations 1, 4 and 6, which include over 90% of the Japanese patients, were not detected. We also reviewed 26 cases of malignant melanoma associated with Werner syndrome (WS), including ours.
authors.affiliation: Department of Anatomy, Biology and Medicine (Plastic Surgery, Dermatology) Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shibuya
authors.forename: Aiko
authors.initials: A
authors.lastname: Kato
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kai
authors.forename: Sakuhei
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Makoto
authors.initials: M
authors.lastname: Goto
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000473:pathology; D005836:Genitalia, Female / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology* / Q000628:therapy; D010502:Perineum; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D013514:Surgical Procedures, Operative / Q000379:methods; D016896:Treatment Outcome; D014898:Werner Syndrome / Q000150:complications* / Q000175:diagnosis