title: Phenotype at diagnosis predicts recurrence rates in Crohn's disease.
abstract: BACKGROUND
  In Crohn's disease (CD), studies associating phenotype at diagnosis and subsequent disease activity are important for patient counselling and health care planning.
  
  
  OBJECTIVE
  To calculate disease recurrence rates and to correlate these with phenotypic traits at diagnosis.
  
  
  METHODS
  A prospectively assembled uniformly diagnosed European population based inception cohort of CD patients was classified according to the Vienna classification for disease phenotype at diagnosis. Surgical and non-surgical recurrence rates throughout a 10 year follow up period were calculated. Multivariate analysis was performed to classify risk factors present at diagnosis for recurrent disease.
  
  
  RESULTS
  A total of 358 were classified for phenotype at diagnosis, of whom 262 (73.2%) had a first recurrence and 113 patients (31.6%) a first surgical recurrence during the first 10 years after diagnosis. Patients with upper gastrointestinal disease at diagnosis had an excess risk of recurrence (hazard ratio 1.54 (95% confidence interval (CI) 1.13-2.10)) whereas age >/=40 years at diagnosis was protective (hazard ratio 0.82 (95% CI 0.70-0.97)). Colonic disease was a protective characteristic for resective surgery (hazard ratio 0.38 (95% CI 0.21-0.69)). More frequent resective surgical recurrences were reported from Copenhagen (hazard ratio 3.23 (95% CI 1.32-7.89)).
  
  
  CONCLUSIONS
  A mild course of disease in terms of disease recurrence was observed in this European cohort. Phenotype at diagnosis had predictive value for disease recurrence with upper gastrointestinal disease being the most important positive predictor. A phenotypic North-South gradient in CD may be present, illustrated by higher surgery risks in some of the Northern European centres.
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital Maastricht, the Netherlands. frankwolters@ace-on-air.nl
authors.forename: F L
authors.initials: FL
authors.lastname: Wolters
authors.forename: M G
authors.initials: MG
authors.lastname: Russel
authors.forename: J
authors.initials: J
authors.lastname: Sijbrandij
authors.forename: T
authors.initials: T
authors.lastname: Ambergen
authors.forename: S
authors.initials: S
authors.lastname: Odes
authors.forename: L
authors.initials: L
authors.lastname: Riis
authors.forename: E
authors.initials: E
authors.lastname: Langholz
authors.forename: P
authors.initials: P
authors.lastname: Politi
authors.forename: A
authors.initials: A
authors.lastname: Qasim
authors.forename: I
authors.initials: I
authors.lastname: Koutroubakis
authors.forename: E
authors.initials: E
authors.lastname: Tsianos
authors.forename: S
authors.initials: S
authors.lastname: Vermeire
authors.forename: J
authors.initials: J
authors.lastname: Freitas
authors.forename: G
authors.initials: G
authors.lastname: van Zeijl
authors.forename: O
authors.initials: O
authors.lastname: Hoie
authors.forename: T
authors.initials: T
authors.lastname: Bernklev
authors.forename: M
authors.initials: M
authors.lastname: Beltrami
authors.forename: D
authors.initials: D
authors.lastname: Rodriguez
authors.forename: R W
authors.initials: RW
authors.lastname: Stockbrügger
authors.forename: B
authors.initials: B
authors.lastname: Moum
mesh_terms: D000328:Adult; D000367:Age Factors; D003424:Crohn Disease / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004812:Epidemiologic Methods; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D012008:Recurrence