title: Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer.
abstract: Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.
authors.affiliation: Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ideta
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Tasaka
authors.forename: Woo-Dong
authors.initials: WD
authors.lastname: Jang
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishiyama
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Zhang
authors.forename: Atsushi
authors.initials: A
authors.lastname: Harada
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yanagi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tamaki
authors.forename: Takuzo
authors.initials: T
authors.lastname: Aida
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D015355:Glaucoma, Neovascular / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D046911:Macromolecular Substances / Q000737:chemistry; D008297:Male; D036103:Nanotechnology / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011166:Porphyrins / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats
chemical_list: D004337:Drug Carriers; D046911:Macromolecular Substances; D017319:Photosensitizing Agents; D011166:Porphyrins