title: Spontaneous ophthalmic diseases in 586 New Zealand white rabbits.
abstract: The purpose of this study was to investigate spontaneous eye disease in New Zealand White (NZW) rabbits, which are commonly used for toxicity tests, and to provide reference materials for pharmaceutical companies and research centers. A total of 586 NZW rabbits were randomly chosen without sex preference and were examined using ocular equipment, including a direct ophthalmoscope, an indirect ophthalmoscope, a slit-lamp biomicroscope, a focal illuminator, and a fundus camera. This study showed that the incidence rate of temporary cataracts, regarded as a change within normal variation, was 0.5% in the NZW rabbits. Regarding abnormal ophthalmic disease, blepharitis was the most commonly observed ocular disease. Other findings included cataract, conjunctivitis, choroidal hypoplasia, keratitis, corneal scarring, eyelid laceration, posterior synechiae, uveitis, dacryocystitis, and persistent pupillary membrane. In total, the incidence rate of ophthalmic diseases was 9.6%. Based on sex and age distributions, females had more ocular diseases than males, and rabbits were less susceptible to eye diseases as they got older. In this study, photographs were taken to document findings, such as normal fundus, normal variations, ophthalmic disease, and histopathologic examination.
authors.affiliation: Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
authors.forename: Man Bok
authors.initials: MB
authors.lastname: Jeong
authors.forename: Na Ra
authors.initials: NR
authors.lastname: Kim
authors.forename: Na Young
authors.initials: NY
authors.lastname: Yi
authors.forename: Shin Ae
authors.initials: SA
authors.lastname: Park
authors.forename: Min Su
authors.initials: MS
authors.lastname: Kim
authors.forename: Jae Hak
authors.initials: JH
authors.lastname: Park
authors.forename: Seong Mok
authors.initials: SM
authors.lastname: Jeong
authors.forename: Kyoung Deok
authors.initials: KD
authors.lastname: Seo
authors.forename: Tchi Chou
authors.initials: TC
authors.lastname: Nam
authors.forename: Yang Seok
authors.initials: YS
authors.lastname: Oh
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Kang Moon
authors.initials: KM
authors.lastname: Seo
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001762:Blepharitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D002386:Cataract / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D003231:Conjunctivitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D003941:Diagnostic Techniques, Ophthalmological; D005123:Eye / Q000473:pathology; D005124:Eye Abnormalities / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D005128:Eye Diseases / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007634:Keratitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D008297:Male; D011817:Rabbits; D012737:Sex Factors