[Comparison CCR5de132 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in different groups of HIV-infected individuals].
The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 107), Tuvinians (n = 50), and HIV-infected individuals were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation.
Apriatin
S A
SA
Rakhmanaliev
E R
ER
Nikolaeva
I A
IA
Ruban
S V
SV
Vazykhova
F G
FG
Klimov
E A
EA
Sulimova
G E
GE
Sidorovich
I G
IG
D000483:Alleles; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D006679:HIV Seropositivity / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000235:genetics*; D012426:Russia; D017384:Sequence Deletion; D044465:White People
D019713:Receptors, CCR5