title: In vitro performance of the novel coronary sinus AutoRetroPerfusion Cannula.
abstract: Myocardial salvage through coronary sinus intervention has been documented. The AutoRetroPerfusion Cannula is a novel device that is able to perfuse the coronary bed retrogradely through the coronary sinus with arterial blood generated from a peripheral artery with no need for a pump. The cannula consists of a distal end that, once secured in the coronary sinus, opens an umbrella-like membrane to create pressure in the coronary sinus, and at the same time has small channels directed backwards to the right atrium to provide pressure relief. The cannula is introduced from the axillary vein under local anesthesia and the proximal end, which consists of a graft, is anastomosed to the axillary artery to start autoperfusion once the distal end is secured in the coronary sinus and the occluding membrane is open. The AutoRetroPerfusion Cannula was tested in the in vitro mock loop under 50-120 mm Hg of proximal pressure and 50, 100, and 150 ml/min of total flow in the cannula. We were able to achieve the nominal design point of 40-80 mm Hg of distal pressure and 50-150 ml/min of distal flow by adjusting the number, diameter, and length of the small backwards channels.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Navia
authors.forename: Firas
authors.initials: F
authors.lastname: Zahr
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: Mark
authors.initials: M
authors.lastname: Goodin
authors.forename: Paul
authors.initials: P
authors.lastname: Ragaller
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kopcak
authors.forename: Raymond
authors.initials: R
authors.lastname: Dessoffy
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Keiji
authors.initials: K
authors.lastname: Kamohara
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akiyama
authors.forename: Antonio
authors.initials: A
authors.lastname: Gutierrez
authors.forename: Jose A
authors.initials: JA
authors.lastname: Navia
authors.forename: Fernando
authors.initials: F
authors.lastname: Atik
authors.forename: Delos M
authors.initials: DM
authors.lastname: Cosgrove
mesh_terms: D001698:Biomedical Engineering; D006328:Cardiac Catheterization / Q000295:instrumentation; D002408:Catheters, Indwelling; D004867:Equipment Design; D006801:Humans; D066298:In Vitro Techniques; D017202:Myocardial Ischemia / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000295:instrumentation*