Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy.
The ketogenic diet is often effective for intractable epilepsy, but many patients have trouble complying with the strict regimen. The authors tested an alternative diet regimen, a low-glycemic-index treatment, with more liberal total carbohydrate intake but restricted to foods that produce relatively little increase in blood glucose (glycemic index < 50). Ten of 20 patients treated with this regimen experienced a greater than 90% reduction in seizure frequency.
Pfeifer
Heidi H
HH
Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Thiele
Elizabeth A
EA
D000140:Acidosis, Lactic / Q000209:etiology / Q000503:physiopathology; D000927:Anticonvulsants / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D004041:Dietary Fats / Q000627:therapeutic use; D004734:Energy Metabolism / Q000502:physiology; D004827:Epilepsy / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D005526:Food, Formulated / Q000592:standards*; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D007659:Ketones / Q000097:blood*; D010349:Patient Compliance; D011584:Psychology; D016896:Treatment Outcome
D000927:Anticonvulsants; D001786:Blood Glucose; D004041:Dietary Fats; D007659:Ketones