Transformation of Adenine to 8-Hydroxyadenine by Strains of Oerskovia xanthineolytica.
The 8-hydroxy derivative of adenine (6-amino-1,7-dihydro-8H-purin-8-one) is produced from adenine by two Oerskovia xanthineolytica strains. This transformation by a microorganism has not been reported previously. No novel products of dissimilation of xanthine (3,7-dihydro-1H-purine-2,6-dione) or hypoxanthine (1,7-dihydro-6H-purin-6-one) were found. Xanthine was oxidized to uric acid, but intermediates in the breakdown of hypoxanthine could not be demonstrated.
Lechevalier
M P
MP
Waksman Institute of Microbiology, Rutgers, The State University, Piscataway, New Jersey 08854.
Gerber
N N
NN
Umbreit
T A
TA