Globus pallidus deep brain stimulation in dystonia.
Globus pallidus deep brain stimulation (GPi-DBS) is a useful alternative in the treatment of dystonia. Patients selected for GPi-DBS were prospectively rated with the Unified Dystonia Rating Scale (UDRS). Also, "blinded" videotape assessments were performed. Eleven patients were identified. Compared with pre-DBS scores, there were improvements in mean total UDRS score (15.3%) and in the following subscores: neck (18.18%), trunk (32.9%), arm (17.9%), and leg (19.9%). One patient developed a skin infection and erosion requiring surgical debridement. GPi-DBS is a safe and effective treatment for generalized dystonia in patients who remained impaired, despite optimal medical therapy.
Diamond
Alan
A
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.
Shahed
Joohi
J
Azher
Shaheda
S
Dat-Vuong
Kevin
K
Jankovic
Joseph
J
D000293:Adolescent; D000328:Adult; D002648:Child; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome