title: Virus membrane-fusion proteins: more than one way to make a hairpin.
abstract: Structure-function studies have defined two classes of viral membrane-fusion proteins that have radically different architectures but adopt a similar overall 'hairpin' conformation to induce fusion of the viral and cellular membranes and therefore initiate infection. In both classes, the hairpin conformation is achieved after a conformational change is triggered by interaction with the target cell. This review will focus in particular on the properties of the more recently described class II proteins.
authors.affiliation: Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. kielian@aecom.yu.edu
authors.forename: Margaret
authors.initials: M
authors.lastname: Kielian
authors.forename: Félix A
authors.initials: FA
authors.lastname: Rey
mesh_terms: D000818:Animals; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D011991:Receptors, Virus / Q000502:physiology; D014760:Viral Fusion Proteins / Q000737:chemistry* / Q000145:classification / Q000502:physiology; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000737:chemistry
chemical_list: D011991:Receptors, Virus; D014760:Viral Fusion Proteins