title: Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates.
abstract: Two series of 2- and 3-[5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio, sulfinyl and sulfonyl] propionic acid alkyl esters were synthesized and screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. The MIC values for the compounds showing more than 90% inhibition were determined. The result of comparison between two groups of data exhibited that among the synthesized derivatives, the compound propyl 3-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-ylthio]propionate was the most active one (MIC=1.56 microgml(-1)).
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Kargar
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sakhteman
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sharifzadeh
authors.forename: Robabeh
authors.initials: R
authors.lastname: Feyzmohammadi
authors.forename: Mahnoush
authors.initials: M
authors.lastname: Kazemi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000478:Alkylation; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009584:Nitrogen / Q000737:chemistry*; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000995:Antitubercular Agents; D011422:Propionates; D013438:Sulfhydryl Compounds; D009584:Nitrogen