How antibodies act as natural adjuvants.
Antibodies can act like adjuvants. They can potently enhance the antibody response, and in the case of IgG and IgE also the T cell response, to the very antigen they are specific for. In this review we will discuss the recent advances made in our understanding of the underlying mechanisms of antibody-mediated feedback enhancement. The immuno-stimulatory properties of IgM, IgG1, IgG2a, IgG2b, IgG3 and IgE will be reviewed in relationship to the complement system and Fc receptors and the physiological relevance will be discussed.
Getahun
Andrew
A
Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden. andrew.getahun@genpat.uu.se
Heyman
Birgitta
B
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000494:pharmacology*; D051379:Mice
D000276:Adjuvants, Immunologic; D000906:Antibodies; D000941:Antigens; D007136:Immunoglobulins