title: Current state and prospects of macromolecular crystallography.
abstract: The current situation and possible future development of macromolecular crystallography are reviewed. The rapid progress and maturation of this field in recent years have to a large extent been made possible by the inspiration and generous support of several active structural genomics initiatives. Two tendencies can be currently observed: one which treats protein crystallography as a highly automatic tool for investigating various biological problems without the need to engage in the intricacies of the technique and a second approach where this method is applied to crystals of difficult, large and complex biological systems, requiring a deeper knowledge of various aspects of crystallography. In the near future it is expected that these two trends will coexist, developing in a parallel fashion.
authors.affiliation: Synchrotron Radiation Research Section, MCL, National Cancer Institute, Argonne National Laboratory, Building 202, 9700 South Cass Avenue, Argonne, IL 60439, USA. dauter@anl.gov
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Dauter
mesh_terms: D018360:Crystallography, X-Ray / Q000639:trends*; D046911:Macromolecular Substances / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances