Allosteric control of oligonucleotide hybridization by metal-induced cyclization.
A bis(terpyridine) modified single-stranded DNA smoothly forms a stable cycle by Fe2+-assisted ring closure. A novel, complex type of allosteric behavior is observed with Zn2+, which reversibly off-regulates binding of a complementary oligonucleotide only in a narrow concentration range.
Göritz
Mareike
M
Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Krämer
Roland
R
D001483:Base Sequence; D003500:Cyclization; D004270:DNA, Circular / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization / Q000379:methods*; D009841:Oligonucleotides / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D004270:DNA, Circular; D004277:DNA, Single-Stranded; D009841:Oligonucleotides; D015032:Zinc