Histology and immunohistology of IgA nephropathy.
IgA nephropathy is a histologically diverse glomerular disease characterized by mesangial or mesangial plus peripheral glomerular capillary immune complex deposits that contain IgA as the dominant or co-dominant immunoglobulin type. The most common histologic manifestation of IgA nephropathy is mesangial proliferative glomerulonephritis (GN), most often focal but not infrequently diffuse. However, the light microscopic appearance of IgA nephropathy spans the entire range from histologically normal to diffuse proliferative and crescentic glomerulonephritis, much as is the case with lupus nephritis. This review examines the histologic diversity as well as the immunohistologic features of IgA nephropathy.
Haas
Mark
M
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. mhaas@jhmi.edu
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology* / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology*; D012720:Severity of Illness Index
D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A