title: Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.
abstract: A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.
authors.affiliation: Department of Medicine, Rayne Building, 5 University Street London, WC1E 6JJ, UK. patrick.vallance@ucl.ac.uk
authors.forename: Patrick
authors.initials: P
authors.lastname: Vallance
authors.forename: Hannah D
authors.initials: HD
authors.lastname: Bush
authors.forename: B James
authors.initials: BJ
authors.lastname: Mok
authors.forename: Ramon
authors.initials: R
authors.lastname: Hurtado-Guerrero
authors.forename: Herpreet
authors.initials: H
authors.lastname: Gill
authors.forename: Sharon
authors.initials: S
authors.lastname: Rossiter
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Wilden
authors.forename: Stephen
authors.initials: S
authors.lastname: Caddick
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002384:Catalysis; D003500:Cyclization; D006867:Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011480:Protease Inhibitors; D013451:Sulfonic Acids; D006867:Hydrolases; D000581:Amidohydrolases; C059999:dimethylargininase; C019723:arginine deiminase