Tissue factor initiated blood coagulation.
Tissue factor (TF) is the cellular receptor and cofactor for blood coagulation factor (F) VII. Exposure of flowing blood to cells that express TF leads to the initiation of blood coagulation. Blood coagulation is tightly regulated to generate a local fibrin clot at the site of vascular injury without compromising blood flow in the vasculature. This chapter describes the initiation and propagation of the response and how it is ultimately down-regulated to prevent widespread inappropriate blood coagulation.
Gomez
Keith
K
Haemostasis and Thrombosis, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.
McVey
John H
JH
D000818:Animals; D001777:Blood Coagulation; D001808:Blood Vessels / Q000473:pathology; D003029:Coagulants / Q000378:metabolism; D015536:Down-Regulation; D005167:Factor VII / Q000737:chemistry* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D013925:Thromboplastin / Q000378:metabolism*
D003029:Coagulants; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D005167:Factor VII; D013925:Thromboplastin