Microarray technology in the investigation of diseases of myocardium with special reference to infection.
Microarrays are now routinely employed to characterize gene expression of thousands of genes from a single hybridization. The genome wide gene expression profile aids in the understanding of genes that may be regulated in a particular pathological condition. This paper provides an overview of microarray technology and its recent developments followed by its usage in studies of cardiovascular disease and how it pertains to viral and parasitic infections of the heart.
Mukherjee
Shankar
S
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Belbin
Thomas J
TJ
Spray
David C
DC
Mukhopadhyay
Aparna
A
Nagajyothi
Fnu
F
Weiss
Louis M
LM
Tanowitz
Herbert B
HB
D001014:Aortic Aneurysm / Q000473:pathology; D006332:Cardiomegaly / Q000473:pathology; D009202:Cardiomyopathies; D002318:Cardiovascular Diseases / Q000473:pathology; D014355:Chagas Disease / Q000473:pathology; D017931:DNA Primers / Q000737:chemistry; D018076:DNA, Complementary / Q000378:metabolism; D005786:Gene Expression Regulation; D006321:Heart / Q000469:parasitology / Q000821:virology; D006801:Humans; D006973:Hypertension / Q000473:pathology; D006984:Hypertrophy; D007091:Image Processing, Computer-Assisted; D007239:Infections; D007249:Inflammation; D018613:Microscopy, Confocal; D017202:Myocardial Ischemia / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D015345:Oligonucleotide Probes / Q000737:chemistry; D017382:Reactive Oxygen Species; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013314:Stress, Mechanical
D017931:DNA Primers; D018076:DNA, Complementary; D015345:Oligonucleotide Probes; D017382:Reactive Oxygen Species