Polidocanol at different concentrations for pleurodesis in rats.
OBJECTIVE
We previously found that 0.5% polidocanol was more effective than tetracycline for pleurodesis in rats. Thus, we conducted the present study to evaluate the efficacy of different concentrations of polidocanol for pleurodesis in rats.


METHODS
We divided 54 albino Wistar rats into six groups. Groups 1, 2, and 3 were given isotonic saline, 35 mg/kg tetracycline, and 0.6 mg of diluted polidocanol, respectively, being the daily recommended dose for humans. Groups 4, 5, and 6 were given 0.5%, 1%, and 2% polidocanol, respectively. All solutions were given intrapleurally in a volume of 0.5 ml. We examined the rats for macroscopic pleural adhesions and compared the mean values of macroscopic scoring among the six groups.


RESULTS
The rats given polidocanol and tetracycline had significantly more adhesions than the control group, and polidocanol at concentrations of 0.5%, 1%, and 2% was more effective for pleurodesis than tetracycline. The diluted polidocanol was not more effective than tetracycline. There was no difference between the effects of the 0.5% and 1% concentrations, but the 2% polidocanol group had significantly more adhesions than the other groups.


CONCLUSIONS
Polidocanol at concentrations of 0.5%, 1%, and 2% was a more effective sclerosing agent than tetracycline for pleurodesis. While 2% polidocanol was the most efficient sclerosing agent, the daily maximum recommended dose of polidocanol for humans was not more effective than tetracycline.
Cetin
Bahadir
B
Department of General Surgery, Ankara Oncology Hospital, Turkey.
Koçkaya
E Arzu
EA
Atalay
Can
C
Akay
M Turan
MT
D000818:Animals; D008297:Male; D018700:Pleurodesis / Q000379:methods*; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012597:Sclerosing Solutions / Q000008:administration & dosage* / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology; D000267:Tissue Adhesions / Q000517:prevention & control
D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols; D013752:Tetracycline