title: Bone metastases in vulvar cancer: a rare metastatic pattern.
abstract: Bone metastases from a vulvar carcinoma are exceptionally rare with only five reported cases in the literature. We report on a patient who was initially treated with radical vulvectomy and bilateral inguinal lymphadenectomy for a vulvar cancer (pT2, pN2 (6/37), M0; G2). Due to a positive nodal status, adjuvant radiation of the vulva and the pelvis was performed additionally. The patient presented 4 months after initial therapy with severe pain in the right humeral shaft due to a pathologic fracture based on an osteoclastic metastasis. During osteosynthetic stabilization histologic and immunohistochemical stain gave evidence of a metastasis of the known vulvar carcinoma. Bone scan showed enhancements in both humeral heads as well as the right distal femur, whereas plain radiographs confirmed further metastases in all suspected areas. In conclusion, bone metastases should be considered in the differential diagnoses of unclear osseous pain in women with a history of vulvar cancer. Immunohistochemical examinations might be important to depict the epithelial character of the tissue and allude to the metastatic nature of such rare lesions. The atypical location should alert the physician to suspect distant metastasis, rather than locoregional disease.
authors.affiliation: Department of Gynecology, University Hospital Marburg, Marburg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Fischer
authors.forename: M
authors.initials: M
authors.lastname: Kuhl
authors.forename: U
authors.initials: U
authors.lastname: Feek
authors.forename: M
authors.initials: M
authors.lastname: Rominger
authors.forename: M L
authors.initials: ML
authors.lastname: Schipper
authors.forename: P
authors.initials: P
authors.lastname: Hadji
authors.forename: U
authors.initials: U
authors.lastname: Wagner
authors.forename: C
authors.initials: C
authors.lastname: Jackisch
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy