title: [A case of curatively resected schirrous gastric cancer effectively treated by combined chemotherapy of weekly paclitaxel (PTX) and CDDP].
abstract: The patient was a 40-year-old woman who had unresectable advanced gastric cancer with invasion of liver and dissemination to the peritoneal wall. Neoadjuvant chemotherapy consisting of paclitaxel (PTX) and CDDP was performed. PTX (80 mg/m2), and CDDP (25 mg/m2) was administered weekly on day 1, 8 and 15 as one cycle. After four cycles of PTX/CDDP administration,invasion of liver and gastric tumor had decreased to almost normal size, and total gastrectomy was performed. After operation, the patient was treated with six courses of PTX/CDDP and survived without recurrence as of this writing. PTX/CDDP was associated with few adverse events in hospital visits, and thought to be an effective chemotherapy against advanced gastric cancer.
authors.affiliation: Dept. of Surgery I, University of Occupational and Environmental Health, School of Medicine.
authors.forename: Naoki
authors.initials: N
authors.lastname: Nagata
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Kentaro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Inoue
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shibao
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Higure
authors.forename: Keiji
authors.initials: K
authors.lastname: Hirata
authors.forename: Hideaki
authors.initials: H
authors.lastname: Itoh
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D005743:Gastrectomy; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*
chemical_list: D017239:Paclitaxel; D002945:Cisplatin