title: Biomarkers for oxidative stress: measurement, validation, and application.
abstract: Biomarkers are essential for assessment of oxidative stress and evaluation of antioxidant capacity in vivo. Total hydroxyoctadecadienoic acid (HODE) and 7-hydroxycholesterol measured after reduction and saponification of biological fluids may be used as reliable biomarker.
authors.affiliation: National Institute of Advanced Industrial Science and Technology, Human Stress Signal Research Center, Osaka, Japan.
authors.forename: Etsuo
authors.initials: E
authors.lastname: Niki
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D028441:F2-Isoprostanes / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D006801:Humans; D006888:Hydroxycholesterols / Q000032:analysis*; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015203:Reproducibility of Results; D013237:Stereoisomerism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D028441:F2-Isoprostanes; D005231:Fatty Acids, Unsaturated; D006888:Hydroxycholesterols; C495366:hydroxyoctadecadienoic acid