title: Overt testicular disease (OTD) at diagnosis is not associated with a poor prognosis in childhood acute lymphoblastic leukemia: results of the EORTC CLG Study 58881.
abstract: To assess the prognosis of overt testicular disease (OTD) at diagnosis of acute lymphoblastic leukemia (ALL), we analyzed the outcome of 1,165 boys enrolled in EORTC trial 58881. Thirteen (1.1%) boys had OTD associated with bad prognostic features. Patients with and without OTD did not differ in event-free survival (EFS) (P=0.30) or overall survival (OS) (P=0.54), even after adjustment for the three most important independent factors (NCI risk group, presence of very high risk features, type of asparaginase used). OTD was not an independent prognostic factor. These results may be due to the use of risk-adjusted intensive chemotherapy comprising high-dose methotrexate.
authors.affiliation: Department of Pediatrics, CHU Nice, Nice, France. sirvent.n@chu-nice.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sirvent
authors.forename: Stefan
authors.initials: S
authors.lastname: Suciu
authors.forename: Yves
authors.initials: Y
authors.lastname: Bertrand
authors.forename: Anne
authors.initials: A
authors.lastname: Uyttebroeck
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lescoeur
authors.forename: Jacques
authors.initials: J
authors.lastname: Otten
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001530:Belgium / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D011174:Portugal / Q000453:epidemiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D015996:Survival Rate; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*