Muscle stem cells and regenerative myogenesis.
A population of myogenic progenitors termed satellite cells undertakes postnatal development and repair of skeletal muscle. Studies have indicated that atypical myogenic precursors can also participate in muscle regeneration. The source of this regenerative capacity has been attributed to "adult stem cells" that represent poorly understood multipotent cell lineages, believed to reside in all adult tissue populations. Here we review the origin and location of muscle satellite cells and stem cells, as well as the mechanisms by which they may be specified. We discuss how the experimental models utilized raise important questions regarding the validity of extrapolating these findings.
McKinnell
Iain W
IW
Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6 Canada.
Parise
Gianni
G
Rudnicki
Michael A
MA
D000818:Animals; D008954:Models, Biological; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*