title: Controlled release tamsulosin hydrochloride from alginate beads with waxy materials.
abstract: The objective of this study was to develop oral controlled release delivery systems for tamsulosin hydrochloride (TSH) using alginate beads with various waxy materials, such as Compritol 888 ATO, Precirol ATO 5 and Gelucires. The beads were prepared from sodium alginate-waxy material-TSH slurry dropped onto calcium chloride to form spherical beads. The effects of the addition of various waxy materials to alginate beads on the drug encapsulation efficiency, bead size and morphology were investigated. The drug encapsulation efficiency significantly increased with the addition of waxy materials. The TSH-loaded alginate beads with and without waxy materials were almost spherical particles with an average diameter of 1.44 and 1.22 mm, respectively. In dissolution study, the TSH-loaded alginate beads with waxy materials exhibited controlled release behaviour over a 6-h period, while beads without waxy materials showed release of 100% TSH within 2 h. These results may be attributed to the formation of a more rigid alginate matrix structure due to incorporated waxy materials. From the Dunnett's t-test and the f2 factor, the release of TSH from alginate beads, a similar dissolution pattern to that of the marketed product (Harunal capsules) could be achieved by adding Gelucire 50/13 into TSH-loaded alginate beads. From these results, oral controlled release of TSH could be achieved with loading in alginate beads with waxy materials, such as Compritol 888 ATO, Precirol ATO 5 and Gelucires.
authors.affiliation: National Research Lab. of Pharmaceutical Technology, College of Pharmacy, Chungnam National University, 220 Gung-dong, Yusung-gu, Daejeon 305-764, Korea.
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Gyeong-Deuk
authors.initials: GD
authors.lastname: Park
authors.forename: Seoung-Wook
authors.initials: SW
authors.lastname: Jun
authors.forename: Sibeum
authors.initials: S
authors.lastname: Lee
authors.forename: Jeong-Sook
authors.initials: JS
authors.lastname: Park
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Hwang
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000464:Alginates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D013449:Sulfonamides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000077409:Tamsulosin
chemical_list: D000317:Adrenergic alpha-Antagonists; D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D013449:Sulfonamides; D020723:Glucuronic Acid; D000077409:Tamsulosin