title: Sodium MR imaging of acute and subacute stroke for assessment of tissue viability.
abstract: Sodium MR imaging at 3.0 T provides high-quality images in acceptable acquisition times that allow assessment of tissue viability as defined by maintenance of sodium ion homeostasis. This application is made feasible for clinical stroke evaluation by an efficient projection pulse sequence with extremely short echo time values. This twisted projection imaging provides high signal-to-noise images at adequate resolution (5 x 5 x 5 mm(3)) in less than 10 minutes at 3.0 T. The images are quantified as tissue sodium concentration (TSC) maps that can be interpreted directly in terms of tissue viability. With infarction, baseline TSC values of less than 45 mmol/L increase at variable rates to approximately 70 mmol/L, allowing monitoring of the progression of stroke pathophysiology.
authors.affiliation: Center for Magnetic Resonance Research, University of Illinois at Chicago Medical Center, IL 60612, USA. kthulbor@uic.edu
authors.forename: Keith R
authors.initials: KR
authors.lastname: Thulborn
authors.forename: Denise
authors.initials: D
authors.lastname: Davis
authors.forename: James
authors.initials: J
authors.lastname: Snyder
authors.forename: Howard
authors.initials: H
authors.lastname: Yonas
authors.forename: Amin
authors.initials: A
authors.lastname: Kassam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D000882:Haplorhini; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012964:Sodium / Q000032:analysis* / Q000378:metabolism; D020521:Stroke / Q000175:diagnosis* / Q000378:metabolism; D014022:Tissue Survival / Q000502:physiology*
chemical_list: D012964:Sodium