title: Influence of vascular filling and perfusion on BOLD contrast during reactive hyperemia in human skeletal muscle.
abstract: Mechanisms generating BOLD contrast are complex and depend on parameters that are prone to large variations, in particular in skeletal muscle. Here, we simultaneously measured perfusion by ASL, and BOLD response in the calf muscle of 6 healthy volunteers during post-ischemic reactive hyperemia. We tested whether the relation between the two was altered for varying degrees of leg vascular replenishment induced by prior positioning of the leg at different heights relative to the heart. We found that the BOLD response depended on perfusion, but also on the degree of repletion of leg blood vessels. We conclude that simultaneous determination of perfusion by ASL is important to identify the mechanisms underlying BOLD contrast in the skeletal muscle.
authors.affiliation: NMR Laboratory, AFM and CEA, IFR 14, Institut de Myologie, Pitié-Salpêtrière University Hospital, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Duteil
authors.forename: C
authors.initials: C
authors.lastname: Wary
authors.forename: J S
authors.initials: JS
authors.lastname: Raynaud
authors.forename: V
authors.initials: V
authors.lastname: Lebon
authors.forename: D
authors.initials: D
authors.lastname: Lesage
authors.forename: A
authors.initials: A
authors.lastname: Leroy-Willig
authors.forename: P G
authors.initials: PG
authors.lastname: Carlier
mesh_terms: D000704:Analysis of Variance; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D007511:Ischemia / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D018482:Muscle, Skeletal / Q000098:blood supply*; D010100:Oxygen / Q000097:blood; D011187:Posture; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D010100:Oxygen