[Lanthanides induce neurotransmitter release from the vesicular pool in rat brain synaptosomes].
The influence of lanthanoids on exocytosis was investigated. It was shown that gadolinium increases the spontaneous release of the glutamate nonmetabolizing analogue [3H]D-aspartate. It was established using the fluorescent dye acridine orange that gadolinium and lanthanum induce exocytosis. The effect was dose-dependent and was maximum at 300 microM Gd3+. The exocytosis induced by gadolinium was calcium-independent. It is suggested that lanthanides induce a vesicular release of neurotransmitters by the mechanisms common for all polyvalent cations.
Lopatina
L P
LP
Vasim
T V
TV
Fedorovich
S V
SV
Konev
S V
SV
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D005089:Exocytosis / Q000187:drug effects; D005682:Gadolinium / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism*; D007811:Lanthanum / Q000494:pharmacology*; D051381:Rats; D013572:Synaptic Vesicles / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*
D001224:Aspartic Acid; C016534:lanthanide nitrate; D018698:Glutamic Acid; D007811:Lanthanum; D005682:Gadolinium