title: Improved protein-adsorption-resistant property of PES/SPC blend membrane by adjustment of coagulation bath composition.
abstract: To improve surface protein-adsorption-resistant property of polyethersulfone (PES) membranes, soybean phosphatidylcholine (SPC) was added to PES casting solution. The blend membranes were prepared by a phase inversion method in a wet process. The surface of PES/SPC blend membranes was characterized by X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). XPS data revealed that the phosphorylcholine (PC) groups were concentrated at the surface by changing the composition of coagulation bath. Addition of N,N-dimethylformamide (DMF) in coagulation bath could prolong coagulation time and facilitate the migration of SPC from polymer bulk to membrane surface. The PES/SPC blend membranes dramatically reduced BSA and fibrinogen adsorption compared to PES control membrane due to effective immobilization of PC groups at the surface of PES/SPC blend membranes.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Yan-qiang
authors.initials: YQ
authors.lastname: Wang
authors.forename: Yan-lei
authors.initials: YL
authors.lastname: Su
authors.forename: Zhong-yi
authors.initials: ZY
authors.lastname: Jiang
mesh_terms: D000327:Adsorption; D004126:Dimethylformamide; D005559:Formamides / Q000737:chemistry; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force / Q000379:methods; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D013450:Sulfones / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D005559:Formamides; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D011108:Polymers; D011506:Proteins; D013450:Sulfones; C022840:polyether sulfone; D004126:Dimethylformamide