Effect of prostaglandin E2 for cervical priming on fetal hemodynamics.
OBJECTIVE
To assess the effect of the prostaglandin E2 (PGE2) on fetal vascular blood flow during cervical priming.


METHODS
In a prospective, observational study, 32 pregnant women > or =37 weeks of gestation requiring PGE2 for induction of labor were recruited. The resistance indices (RIs) of umbilical artery, middle cerebral artery, renal artery and ductus venosum were measured before, 2 and 4 hours after insertion of a PGE2 vaginal pessary.


RESULTS
There were no significant changes in RIs of various fetal vessels during cervical priming with PGE2.


CONCLUSIONS
There was no significant change in fetal hemodynamics after vaginal prostaglandin administration. This finding provides further evidence to support the safety of prostaglandin for normal fetuses.
Fok
Wing Yee
WY
Department of Obstetrics and Gynecology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong. angelfok@cuhk.edu.hk
Leung
Tak Yeung
TY
Tsui
Michelle H Y
MH
Leung
Tse Ngong
TN
Lau
Tze Kin
TK
D000282:Administration, Intravaginal; D000328:Adult; D001158:Arteries / Q000187:drug effects*; D020070:Cervical Ripening / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000187:drug effects / Q000502:physiology; D005333:Fetus / Q000098:blood supply / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007751:Labor, Induced; D007743:Labor, Obstetric; D010120:Oxytocics / Q000494:pharmacology*; D011247:Pregnancy; D011446:Prospective Studies
D010120:Oxytocics; D015232:Dinoprostone