Chemokine receptors and transplantation.
A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in the early and late stage of the allogeneic response. This review focuses on the impact of these chemoattractant proteins on transplant outcome and novel diagnostic and therapeutic approaches for antirejection therapy based on targeting of chemokine receptors and/or their ligands.
Tan
Jinquan
J
Department of Immunology, Wuhan University School of Medicine, China. jinquan_tan@hotmail.com
Zhou
Gang
G
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D016503:Drug Delivery Systems; D015195:Drug Design; D006084:Graft Rejection / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D008198:Lymph Nodes / Q000276:immunology; D016377:Organ Transplantation; D019707:Receptors, Chemokine / Q000819:agonists / Q000037:antagonists & inhibitors / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D008024:Ligands; D019707:Receptors, Chemokine