title: Infliximab-responsive uveitis and vasculitis in a patient with Takayasu arteritis.
abstract: Uveitis rarely occurs in patients with Takayasu arteritis (TA) and may be the presenting manifestation in some. We present the case of a 22-year-old black woman who presented with bilateral uveitis. She was subsequently diagnosed with TA and treated with high doses of corticosteroids and methotrexate. However, she experienced recurrent episodes of uveitis and arteritis on this regimen. Addition of infliximab resulted in resolution of both uveitis and arteritis, thereby permitting tapering of steroids and discontinuation of methotrexate over a period of 1 year. The case highlights the importance of keeping TA in the differential in patients with uveitis and considering infliximab in resistant uveitis and patients with TA.
authors.affiliation: Department of Medicine, University of Illinois at Chicago, 4440 West 95th Street, Oak Lawn, IL 60453, USA. Meenashijolly_1@hotmail.com
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Jolly
authors.forename: James J
authors.initials: JJ
authors.lastname: Curran
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000069285:Infliximab; D013625:Takayasu Arteritis / Q000150:complications* / Q000175:diagnosis; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab