Do soy isoflavones cause endometrial hyperplasia?
For many years, hormone replacement therapy (HRT) was considered the gold standard for the symptomatic treatment of menopause. Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been shown to be protective against colon cancer (37%) and hip fractures (34%). However, recent findings from the Women's Health Initiative (WHI) have revealed that long-term HRT may actually lead to an increase in heart disease (29%), breast cancer (26%) and other adverse events, such as stroke (41%). Consequently, many women in the United States and abroad are actively looking for alternative treatments for menopause, including botanical dietary supplements.
Mahady
Gail B
GB
Department of Pharmacy Practice, Room 122, College of Pharmacy, University of Illinois, 833 S. Wood St., MC 886, Chicago, IL 60612, USA. mahady@uic.edu
D000818:Animals; D004714:Endometrial Hyperplasia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000009:adverse effects*; D008251:Macaca; D008593:Menopause / Q000502:physiology; D051379:Mice; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects; D017698:Postmenopause / Q000502:physiology; D013025:Glycine max / Q000009:adverse effects*
D007529:Isoflavones; D010936:Plant Extracts