title: Polidocanol at different concentrations for pleurodesis in rats.
abstract: OBJECTIVE
  We previously found that 0.5% polidocanol was more effective than tetracycline for pleurodesis in rats. Thus, we conducted the present study to evaluate the efficacy of different concentrations of polidocanol for pleurodesis in rats.
  
  
  METHODS
  We divided 54 albino Wistar rats into six groups. Groups 1, 2, and 3 were given isotonic saline, 35 mg/kg tetracycline, and 0.6 mg of diluted polidocanol, respectively, being the daily recommended dose for humans. Groups 4, 5, and 6 were given 0.5%, 1%, and 2% polidocanol, respectively. All solutions were given intrapleurally in a volume of 0.5 ml. We examined the rats for macroscopic pleural adhesions and compared the mean values of macroscopic scoring among the six groups.
  
  
  RESULTS
  The rats given polidocanol and tetracycline had significantly more adhesions than the control group, and polidocanol at concentrations of 0.5%, 1%, and 2% was more effective for pleurodesis than tetracycline. The diluted polidocanol was not more effective than tetracycline. There was no difference between the effects of the 0.5% and 1% concentrations, but the 2% polidocanol group had significantly more adhesions than the other groups.
  
  
  CONCLUSIONS
  Polidocanol at concentrations of 0.5%, 1%, and 2% was a more effective sclerosing agent than tetracycline for pleurodesis. While 2% polidocanol was the most efficient sclerosing agent, the daily maximum recommended dose of polidocanol for humans was not more effective than tetracycline.
authors.affiliation: Department of General Surgery, Ankara Oncology Hospital, Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Cetin
authors.forename: E Arzu
authors.initials: EA
authors.lastname: Koçkaya
authors.forename: Can
authors.initials: C
authors.lastname: Atalay
authors.forename: M Turan
authors.initials: MT
authors.lastname: Akay
mesh_terms: D000818:Animals; D008297:Male; D018700:Pleurodesis / Q000379:methods*; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012597:Sclerosing Solutions / Q000008:administration & dosage* / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols; D013752:Tetracycline