title: Allograft reconstruction for bone sarcoma of the tibia in the growing child.
abstract: The outcome of tibial allograft reconstruction after resection of a tumour is inconsistent and has a high rate of failure. There are few reports on the use of tibial allografts in children with open growth plates. We performed 21 allograft reconstructions (16 osteoarticular, five intercalary) in 19 consecutive patients between seven and 17 years of age. Two had Ewing's sarcoma, one an adamantinoma and 16 osteosarcoma, one with multifocal disease. Five patients have died; the other 14 were free from disease at the time of follow-up. Six surviving patients (eight allograft reconstructions) continue to have good or excellent function at a mean of 59 months (14 to 132). One patient has poor function at 31 months. The other seven patients have a good or excellent function after additional procedures including exchange of the allograft and resurfacing or revision to an endoprosthesis at a mean of 101 months (43 to 198). The additional operations were performed at a mean of 47 months (20 to 84) after the first reconstruction. With the use of allograft reconstruction in growing children, joints and growth plates may be preserved, at least partially. Although our results remain inconsistent, tibial allograft reconstruction in selected patients may restore complete and durable function of the limb.
authors.affiliation: Department of Orthopaedics, University of Zürich, Balgrist, Forchstrasse 340, CH-8008 Zürich, Switzerland.
authors.forename: L E
authors.initials: LE
authors.lastname: Ramseier
authors.forename: T I
authors.initials: TI
authors.lastname: Malinin
authors.forename: H T
authors.initials: HT
authors.lastname: Temple
authors.forename: W A
authors.initials: WA
authors.lastname: Mnaymneh
authors.forename: G U
authors.initials: GU
authors.lastname: Exner
mesh_terms: D050398:Adamantinoma / Q000601:surgery; D000293:Adolescent; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods* / Q000534:rehabilitation; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007870:Leg Length Inequality / Q000209:etiology; D008297:Male; D012516:Osteosarcoma / Q000601:surgery*; D011859:Radiography; D012086:Reoperation / Q000379:methods; D012512:Sarcoma, Ewing / Q000601:surgery; D013977:Tibia / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing