title: High-resolution computed tomography findings of lung cancer associated with idiopathic pulmonary fibrosis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate high-resolution computed tomography (HRCT) findings of lung cancer associated with idiopathic pulmonary fibrosis (IPF).
  
  
  METHODS
  Thirty patients with lung cancer who had preceding IPF and were receiving regular follow-up between 1993 and 2002 were examined. Medical records, radiographs (including HRCT scans), and histologic slides were reviewed.
  
  
  RESULTS
  In 28 of the 30 patients, the most common HRCT pattern of lung cancer was a nodular lesion with soft tissue attenuation. Nodule margins were well defined in 23 lesions (82.1%), associated with lobulation in 24 (85.7%), or characterized by spiculation in 14 (50%). Air bronchogram was observed in 16 lesions (57.1%). All nodules were located in the peripheral area of fibrotic lesions. Squamous cell carcinoma and adenocarcinoma were the most frequent histologic types.
  
  
  CONCLUSIONS
  The typical HRCT findings of lung cancer were well-defined nodular lesions with lobulation in peripheral areas of the lung.
authors.affiliation: Department of Clinical Oncology, Toranomon Hospital, Tokyo, Japan. kazumak@toranomon.gr.jp
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kishi
authors.forename: Sakae
authors.initials: S
authors.lastname: Homma
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kurosaki
authors.forename: Noriko
authors.initials: N
authors.lastname: Motoi
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Yoshimura
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*