title: Reversibility of hypogonadotropic hypogonadism in a patient with the juvenile form of hemochromatosis.
abstract: OBJECTIVE
  To report a case of complete reversibility of hypogonadotropic hypogonadism with intensive venesection treatment in juvenile hemochromatosis.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Endocrine department of Hippocrateion Hospital of Athens.
  
  
  METHODS
  A 25-year-old man who presented with hypogonadotropic hypogonadism and severe iron overload due to juvenile hemochromatosis and who was initially treated with phlebotomies and androgen substitution.
  
  
  METHODS
  Intensification of chelation therapy.
  
  
  METHODS
  Clinical evaluation, serum ferritin concentration, and biochemical assessment of pituitary function were performed periodically.
  
  
  RESULTS
  One year after normalization of serum ferritin levels and transferrin saturation was achieved, he became eugonadal.
  
  
  CONCLUSIONS
  We believe that hypogonadotropic hypogonadism in juvenile hemochromatosis may be reversible by a consequent venesection therapy probably because treatment was intensive and promptly introduced at a young age.
authors.affiliation: Endocrine Department, Hippokrateion Hospital of Athens, Athens, Greece. drangelnick@hotmail.com
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Angelopoulos
authors.forename: Anastasia
authors.initials: A
authors.lastname: Goula
authors.forename: Evagelos
authors.initials: E
authors.lastname: Dimitriou
authors.forename: George
authors.initials: G
authors.lastname: Tolis
mesh_terms: D000328:Adult; D000367:Age Factors; D005293:Ferritins / Q000097:blood; D006432:Hemochromatosis / Q000150:complications* / Q000628:therapy*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology* / Q000628:therapy*; D008297:Male; D018962:Phlebotomy; D012074:Remission Induction; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D005293:Ferritins