Effect of sodium thiosulphate and cis-diamminedichloroplatinum on FADU tumour cells in nude mice.
OBJECTIVE
To study the effect of cis-diamminedichloroplatinum (CDDP) on FADU squamous cell carcinoma cells in a nude mouse model and to determine the effect of sodium thiosulphate (STS) on CDDP activity.


METHODS
CD1 nude mice were inoculated with FADU tumour cells to both flanks. They were then randomized to four treatment groups: control, CDDP only, STS only, or CDDP and STS. Tumour growth was measured using calipers and charted at 3-day intervals.


RESULTS
Tumour volumes were calculated as an ellipsoid and charted against time.


CONCLUSIONS
CDDP inhibited FADU tumour cell growth compared with saline controls (p < .005). The addition of STS did not inhibit the CDDP activity when compared with CDDP-alone activity (p = .989). Compared with saline control solution, STS alone also inhibited tumour growth significantly (p < .005).
Viallet
Norbert R
NR
Department of Otolaryngology, University of Manitoba, Winnipeg, MB.
Blakley
Brian W
BW
Begleiter
Asher
A
Leith
Marsha K
MK
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004347:Drug Interactions; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011897:Random Allocation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013885:Thiosulfates / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D000975:Antioxidants; D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin