[Efficacy of prednisolone and rimexolone in HLA-B27 positive patients with acute anterior uveitis].
OBJECTIVE
To compare the efficacy and safety of prednisolone acetate 1% vs. rimexolone 1% ophthalmic suspension in the treatment of acute anterior uveitis (AAU) in HLA-B27+ patients.


METHODS
Sixty-eight AAU HLA-B27+ patients were randomly selected for treatment with prednisolone acetate 1% or Rimexolone 1%. All patients showed mild to moderate anterior chamber inflammation. This was a prospective, randomized, double blind, clinical trial.


RESULTS
There was no statistically significant difference between both groups when anterior chamber cells were measured. In the rimexolonae group, flare diminished since the first week. In both groups the intraocular pressure (IOP) raised since the first week, the increase was highly significant in the rimexolone group. Final intraocular pressure was higher in the prednisolone group.


CONCLUSIONS
Rimexolone 1% is as effective as prednisolone acetate 1% in the treatment of mild to moderate AAU HLA-B27+. IOP increased in both groups, but this variation was not clinically significant.
Arellanes-García
Lourdes
L
Clínica de Enfermedades Inflamatorias Oculares, Hospital Dr Luis Sánchez Bulnes de la Asociación para Evitar la Ceguera en México, Coyoacán. agml@servidor.unam.mx
Padilla-Aguilar
Gonzalo
G
Navarro-López
Patricia
P
Espinoza-Martínez
Cynthia
C
D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D011245:Pregnadienes / Q000627:therapeutic use*; D011446:Prospective Studies; D014605:Uveitis / Q000097:blood / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D015796:HLA-B27 Antigen; D011245:Pregnadienes; D011239:Prednisolone; C013769:rimexolone