[The influence of sodium nitroprusside, the possible donor of nitric oxide on activity ATPases and lipid peroxidation of erythrocytes of sick children].
The effect of sodium nitroprusside, possible nitric oxide donor, on the activities of Ca2+, Mg(2+)- and Na+, K(+)-ATPases and lipid peroxidation was investigated in erythrocytes in vitro. Sodium nitroprusside caused 3-fold increase of mechanical and peroxidative erythrocyte hemolysis and also increase of bound malonic dialdehyde. Sodium nitroprusside-treated erythrocytes were also characterized by increased Na+, K(+)-ATPase activity.
Vasil'eva
E M
EM
Bakanov
M I
MI
Markov
Kh M
KhM
Altyrtsev
V V
VV
Malyshko
T K
TK
Terekhova
T V
TV
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D002648:Child; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000032:analysis; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*
D020030:Nitric Oxide Donors; D009599:Nitroprusside; D008315:Malondialdehyde; D000251:Adenosine Triphosphatases