title: Lung cancer risk and occupational exposure to meat and live animals.
abstract: An increased risk of lung cancer has been reported for butchers and meat workers in several cohort studies, although confounding from tobacco smoking could not be ruled out in any of these studies. These exposures, as well as a potential risk associated with contact with live animals, are addressed here in a large case-control study with full adjustment for smoking. More than 5,900 subjects were included in a case-control study conducted in 7 European countries. For each job they employed local experts who assessed the exposure to a number of occupational agents, including (i) meat aerosols and (ii) live animals, on the basis of detailed occupational questionnaires. Information on tobacco consumption and other risk factors was also collected. A small increased risk of lung cancer was observed with exposure to meat aerosols, after adjusting for smoking, (odds ratio (OR)=1.27, 95% confidence interval (CI): 0.92, 1.75), which was most apparent for the upper tertile of cumulative exposure (OR=1.73, 95% CI: 1.03, 2.92). A similar overall effect was observed for exposure to live animals, with an increased risk observed for a high frequency of exposure, (OR=1.69, 95% CI: 1.21, 2.36) and a high intensity of exposure, (OR=1.85, 95% CI: 1.16, 2.94), with significant trends for increasing frequency (p=0.012), intensity (p=0.015) and cumulative exposure (p=0.024). In conclusion, this study provides evidence for an association between exposure to meat aerosols and lung cancer apparent in the highest tertile of exposure. The authors identified a more consistent association with exposure to live animals.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Raika
authors.initials: R
authors.lastname: Durusoy
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Andrea 't
authors.initials: A'
authors.lastname: Mannetje
authors.forename: David
authors.initials: D
authors.lastname: Zaridze
authors.forename: Neonila
authors.initials: N
authors.lastname: Szeszenia-Dabrowska
authors.forename: Peter
authors.initials: P
authors.lastname: Rudnai
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.forename: Eleonóra
authors.initials: E
authors.lastname: Fabiánová
authors.forename: Adrian
authors.initials: A
authors.lastname: Cassidy
authors.forename: Dana
authors.initials: D
authors.lastname: Mates
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bencko
authors.forename: Frantisek
authors.initials: F
authors.lastname: Salajka
authors.forename: Vladimir
authors.initials: V
authors.lastname: Janout
authors.forename: Joelle
authors.initials: J
authors.lastname: Fevotte
authors.forename: Tony
authors.initials: T
authors.lastname: Fletcher
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
mesh_terms: D000328:Adult; D000336:Aerosols; D000368:Aged; D000818:Animals; D000829:Animals, Domestic; D016022:Case-Control Studies; D005060:Europe; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008460:Meat; D008875:Middle Aged; D016273:Occupational Exposure; D009790:Occupations; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D000336:Aerosols