Diastereoselective, titanium-mediated cyclization of omega-vinyl tethered imides.
[reaction: see text] Diastereoselective reductive coupling reactions of omega-vinyl tethered cyclic imides are achieved by a preexisting stereocenter at an allylic position. Particularly noteworthy is the effective use of a 1:2 mixture of Ti(O-i-Pr)4 and n-BuLi to afford the N-acylhemiaminal products in good yields.
Santra
Soumava
S
Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, Michigan 48202, USA.
Masalov
Nikolai
N
Epstein
Oleg L
OL
Cha
Jin Kun
JK