title: Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major.
abstract: Serum non-transferrin-bound iron (NTBI) levels assessed at arbitrary time points during transfusion cycles may not be representative if NTBI is undergoing significant changes during transfusion cycles. In 15 patients with beta-thalassemia major (age: 21 +/- 6 years, liver iron concentration: 2200 +/- 1200 microg/g-liver), NTBI and other hematologic parameters (transferrin saturation, transferrin receptor) were measured weekly. The largest variation of NTBI levels between individual patients was observed at midcycle. For long-term monitoring of NTBI levels, a particular time point relative to the last blood transfusion should be selected for blood drawing.
authors.affiliation: University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology/Oncology, Martinistr. 52, Hamburg D-20246, Germany. regine_grosse@web.de
authors.forename: Regine
authors.initials: R
authors.lastname: Grosse
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lund
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Caruso
authors.forename: Roland
authors.initials: R
authors.lastname: Fischer
authors.forename: Gritta E
authors.initials: GE
authors.lastname: Janka
authors.forename: Carmelo
authors.initials: C
authors.lastname: Magnano
authors.forename: Rainer
authors.initials: R
authors.lastname: Engelhardt
authors.forename: Matthias
authors.initials: M
authors.lastname: Dürken
authors.forename: Peter
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D000293:Adolescent; D000328:Adult; D001800:Blood Specimen Collection; D001803:Blood Transfusion; D015913:Chelation Therapy; D003131:Combined Modality Therapy; D003676:Deferoxamine / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D007501:Iron / Q000097:blood*; D007502:Iron Chelating Agents / Q000627:therapeutic use; D008099:Liver / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D011446:Prospective Studies; D011990:Receptors, Transferrin / Q000032:analysis; D015203:Reproducibility of Results; D013997:Time Factors; D014168:Transferrin / Q000032:analysis; D017086:beta-Thalassemia / Q000097:blood / Q000188:drug therapy / Q000628:therapy*
chemical_list: D007502:Iron Chelating Agents; D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron; D003676:Deferoxamine