title: [Genetic aspects of premature ovarian failure].
abstract: Among the causes of premature ovarian failure (POF) two groups of factors are reported: factors which lead to decrease of follicular number and factors which stimulate follicular atresia. In the first group genetic factors are the most important whereas in the second: enzymatic autoimmunological, iatrogenic, toxins and infections are reported. In 1986 familiar POF on the background of long arm of chromosome X deletion was reported. Other chromosomes which are important for normal ovarian function are: chromosome 21 (AIRE gene), chromosome 11 (gene of beta FSH, ATM gene), chromosome 3 (gene responsible for BEPS syndrome) and chromosome 2 (genes of FSH and LH receptors). In this review the role of these genes and results of several epidemiological studies are reported.
authors.affiliation: Department of Endocrine Gynaecology, Poznan University of Medical Sciences, Poznan.
authors.forename: Alina
authors.initials: A
authors.lastname: Warenik-Szymankiewicz
authors.forename: Radosław
authors.initials: R
authors.lastname: Słopień
mesh_terms: D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000235:genetics*; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D008297:Male; D016649:Primary Ovarian Insufficiency / Q000235:genetics*
chemical_list: D043373:Follicle Stimulating Hormone, Human