title: Cytotoxic constituents from the whole plant of Corydalis pallida.
abstract: Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 microg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Hyang Rim
authors.initials: HR
authors.lastname: Kim
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Min
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Jeong
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Nam Sook
authors.initials: NS
authors.lastname: Lee
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Seo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D031311:Corydalis / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D001599:Berberine