title: Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats.
abstract: In this rat model study we evaluated whether pretreatment with simvastatin affects the severity of acute lung injury caused by intestinal ischemia-reperfusion (I/R). Twenty-four animals were randomly allocated to three equal groups (sham, control, simvastatin). The simvastatin group was pretreated with simvastatin 10 mg x kg(-1) x day(-1) for 3 days, whereas the other groups received placebo. The simvastatin and control groups underwent 60 min of superior mesenteric artery occlusion and 90 min of reperfusion. Compared with the simvastatin group, the control group exhibited significantly more severe intestinal I/R-induced acute lung injury, as indicated by lower Pao2 and oxygen saturation (P = 0.01 and P = 0.005, respectively) and higher mean values for neutrophil infiltration of the lungs (P = 0.003), total lung histopathologic injury score (P = 0.003), lung wet-to-dry weight ratio (P = 0.009), and lung-tissue malondialdehyde levels (P = 0.016). The control and simvastatin groups had similar serum levels and similar bronchoalveolar lavage fluid levels of cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) and P-selectin at all measurements, except for a significantly higher level of bronchoalveolar lavage fluid P-selectin in the control group (P = 0.006). Pretreatment with simvastatin reduces the severity of acute lung injury induced by intestinal I/R in rats.
authors.affiliation: Department of Anesthesiology, Baskent University Faculty of Medicine, Ankara, Turkey. arashp@baskent-ank.edu.tr
authors.forename: Arash
authors.initials: A
authors.lastname: Pirat
authors.forename: Pinar
authors.initials: P
authors.lastname: Zeyneloglu
authors.forename: Derya
authors.initials: D
authors.lastname: Aldemir
authors.forename: Muammer
authors.initials: M
authors.lastname: Yücel
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozen
authors.forename: Selim
authors.initials: S
authors.lastname: Candan
authors.forename: Gülnaz
authors.initials: G
authors.lastname: Arslan
mesh_terms: D000818:Animals; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000098:blood supply* / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury; D008297:Male; D011292:Premedication / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D019821:Simvastatin / Q000008:administration & dosage*
chemical_list: D019821:Simvastatin