title: Anaphase topsy-turvy: Cdk1 a securin, separase a CKI.
abstract: Chromosome segregation in mitosis and meiosis is triggered by activation of a large protease, separase. While it has been known for some time that the anaphase inhibitor securin regulates separase activity recent work shows that this is only half the story. In vertebrates Cdk1-dependent inhibition of separase represents a second, securin-independent branch of anaphase regulation. Furthermore, an unanticipated ability of separase to inhibit Cdk1 suggests additional, nonproteolytic functions of separase.
authors.affiliation: Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany. stemmann@biochem.mpg.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Stemmann
authors.forename: Ingo H
authors.initials: IH
authors.lastname: Gorr
authors.forename: Dominik
authors.initials: D
authors.lastname: Boos
mesh_terms: D000705:Anaphase; D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D064247:Separase
chemical_list: D018797:Cell Cycle Proteins; D016203:CDC2 Protein Kinase; D010450:Endopeptidases; C577987:ESPL1 protein, human; D064247:Separase