[Comparative efficacy of fixed dose combinations of enalapril with hydrochlorothiazide and captopril with hydrochlorothiazide in patients with high risk hypertension].
Clinical effectiveness and tolerability of o.d. use of fixed dose combinations of enalapril (10 mg) with hydrochlorothiazide (25 mg) (Enap H) and captopril (50 mg) with hydrochlorothiazide (25 mg) (Capozide) were compared in a randomized study on 60 patients with I-II degree high and very high risk hypertension. Study duration was 6 months, number of patients in each of parallel groups -- 30. Antihypertensive activity, ability to improve arterial elasticity and T/P parameter, cost/efficacy index of enalapril (10 mg) plus hydrochlorothiazide (25 mg) combination was found to be superior to those of captopril (50 mg) plus hydrochlorothiazide (25 mg) combination.
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D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000191:economics; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000191:economics; D002216:Captopril / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D004232:Diuretics / Q000008:administration & dosage* / Q000191:economics; D004338:Drug Combinations; D004656:Enalapril / Q000008:administration & dosage* / Q000191:economics; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000191:economics / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000191:economics; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics; D004338:Drug Combinations; C044959:captopril, hydrochlorothiazide drug combination; D006852:Hydrochlorothiazide; D004656:Enalapril; D002216:Captopril