title: Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas.
abstract: Natural killer cells are well known to play an important role in immune defense against tumor development and viral infections. To further characterize new functionally relevant structures in these cells, we studied a series of monoclonal antibodies that we have raised against the NK cell line YT. One of these antibodies previously described as AY19, recognizes a 85 kD surface glycoprotein. Here we report the identification of a new secreted isoform of protocadherin 15, PCDH15C, which represents a potential associated protein for p85. Importantly, whereas protocadherins are absent from the surface of normal hematopoietic cells, we describe, for the first time, that PCDH15 is expressed in cytotoxic tumor-derived T- and NK-cell lines as well as in biopsies of nasal NK/T-cell lymphomas.
authors.affiliation: Inserm Unité 659, Faculté de médecine, Créteil, France.
authors.forename: V
authors.initials: V
authors.lastname: Rouget-Quermalet
authors.forename: J
authors.initials: J
authors.lastname: Giustiniani
authors.forename: A
authors.initials: A
authors.lastname: Marie-Cardine
authors.forename: G
authors.initials: G
authors.lastname: Beaud
authors.forename: F
authors.initials: F
authors.lastname: Besnard
authors.forename: D
authors.initials: D
authors.lastname: Loyaux
authors.forename: P
authors.initials: P
authors.lastname: Ferrara
authors.forename: K
authors.initials: K
authors.lastname: Leroy
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: P
authors.initials: P
authors.lastname: Gaulard
authors.forename: A
authors.initials: A
authors.lastname: Bensussan
authors.forename: C
authors.initials: C
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D019556:COS Cells; D000070585:Cadherin Related Proteins; D015820:Cadherins / Q000378:metabolism*; D002522:Chlorocebus aethiops; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D009669:Nose Neoplasms / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; C498835:CDHR15, human; D000070585:Cadherin Related Proteins; D015820:Cadherins; D020033:Protein Isoforms; D011498:Protein Precursors