[Behavioral activity and stress reaction of the pituitary-adrenocortical axis in rat with prenatal inhibition of testosterone metabolism].
The effects of maternal administration of the aromatase inhibitor, 1,4,6-androstatrien-3,17-dione (ATD), during the last week of gestation on stress reaction of the hypothalamic-pituitary-adrenal axis (HPA) and behavior in a novel environment (open field) and the anxiety level in the elevated plusmaze, were studied in male and female adult offspring. The results showed that parental inhibition of brain testosterone metabolism decreases the basic level of corticosterone in male rats and prolongs hormonal stress reaction of the HPA axis in both sexes. Prenatally treated rats demonstrated significant elevation of the anxiety level and emotionality. There was no sexual dimorphism in behavioral response to a novel environment such as locomotor activity, the time of immobilization, the total duration of grooming reaction, and the anxiety level, between control male and treated female rats. These data suggest a prenatal inhibition of the brain testosterone metabolism after the stress reaction of HPA axis and formation of sexual dimorphism in the anxiety and behavioral response to a novel environment in adulthood.
Pivina
S G
SG
Akulova
V K
VK
Ordian
N E
NE
D000733:Androstatrienes / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000378:metabolism*; D001141:Aromatase / Q000187:drug effects; D047072:Aromatase Inhibitors / Q000494:pharmacology; D001522:Behavior, Animal; D003345:Corticosterone / Q000097:blood; D005260:Female; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism*; D013739:Testosterone / Q000037:antagonists & inhibitors*
C115984:1,4,6-androstatrien-3,17-dione; D000733:Androstatrienes; D047072:Aromatase Inhibitors; D013739:Testosterone; D001141:Aromatase; D003345:Corticosterone