Disruption of methyl group metabolism by ethanol.
Recent studies have focused on establishing a link between the pathogenesis of ethanol and the disruption of metabolic pathways in the liver. Ethanol alters hepatic methionine metabolism, leading to perturbation of S-adenosylmethionine-dependent transmethylation. Therefore, the supply of metabolically related nutrients such as folate may play a role in the hepatotoxic effects of ethanol.
Schalinske
Kevin L
KL
Department of Food Science and Human Nutrition, Iowa State University, 220 MacKay Hall, Ames, IA 50011, USA. kschalin@iastate.edu
Nieman
Kristin M
KM
D000818:Animals; D002492:Central Nervous System Depressants / Q000009:adverse effects / Q000494:pharmacology*; D000431:Ethanol / Q000009:adverse effects / Q000494:pharmacology*; D005492:Folic Acid / Q000187:drug effects / Q000378:metabolism*; D005494:Folic Acid Deficiency / Q000378:metabolism; D006710:Homocysteine / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000293:injuries / Q000378:metabolism*; D008715:Methionine / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013552:Swine; D013556:Swine, Miniature
D002492:Central Nervous System Depressants; D006710:Homocysteine; D000431:Ethanol; D005492:Folic Acid; D008715:Methionine