title: An analysis of oral and maxillofacial pathology found in children over a 30-year period.
abstract: OBJECTIVE
  The vast majority of oral diseases are confined to oral tissues, but numerous underlying systemic conditions may present with signs and symptoms within the oral cavity. Since the epidemiology of diseases is variable between regions, the authors carried out Europe's first paediatric-based survey of oral and maxillofacial pathology specimens submitted for diagnosis.
  
  
  METHODS
  All entries for specimens from children between the ages of 0 and 16 years during the 30-year period from 1973 to 2002 were retrieved and compiled into 12 diagnostic categories.
  
  
  RESULTS
  During the study period, 4406 (8.2%) specimens came from children between the ages of 0 and 16 years, with a male to female ratio of 1.01. The diagnostic category with the largest number of specimens was tooth pathology (22.1%), followed by salivary gland disease (19.1%) and mucosal pathology (12.1%). In all, there were 114 benign tumours of nonodontogenic origin, 43 odontogenic tumours and 31 malignant tumours. The most frequently diagnosed lesions were mucous extravasation cysts, which accounted for over 16% of cases. Periapical pathology in the form of a radicular cyst, residual cyst or chronic periapical granuloma formed almost 13% of all cases.
  
  
  CONCLUSIONS
  This survey shows that, while nearly 10% of specimens submitted to the authors' laboratory are from children under 16 years of age, the majority of lesions are of a benign nature, requiring minimal intervention; less than 1% of cases comprise malignant lesions. Odontogenic tumours are relatively rare in this age group; however, certain lesions such as adenomatoid odontogenic tumour and ameloblastic fibroma occur predominantly in children and, therefore, remain an important diagnostic consideration.
authors.affiliation: Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK.
authors.forename: A V
authors.initials: AV
authors.lastname: Jones
authors.forename: C D
authors.initials: CD
authors.lastname: Franklin
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology*; D009062:Mouth Neoplasms / Q000453:epidemiology; D009078:Mucocele / Q000453:epidemiology; D009808:Odontogenic Tumors / Q000453:epidemiology; D010484:Periapical Granuloma / Q000453:epidemiology; D011842:Radicular Cyst / Q000453:epidemiology; D012189:Retrospective Studies; D012466:Salivary Gland Diseases / Q000453:epidemiology; D012737:Sex Factors; D014076:Tooth Diseases / Q000453:epidemiology*; D006113:United Kingdom / Q000453:epidemiology