[Application of HPLC/ELSD fingerprint and constellation graphical clustering method applied to evaluate the quality of Qingkailing injection].
OBJECTIVE
To evaluate the quality of Qingkailing injections effectively, and to develop a credible method for the quality control of traditional Chinese medicine.


METHODS
Fingerprints of 18 Qingkailing injection samples from various manufacturers were obtained by HPLC/ELSD, and quality evaluation was performed by constellation graphical clustering method.


RESULTS
HPLC/ELSD and constellation graphical clustering method properly revealed the quality information apparently and accurately.


CONCLUSIONS
It was an apparent, credible and efficient method for quality evaluation of Chinese medicines.
Yan
Shi-Kai
SK
Department of Chinese Medicine Science and Engineering, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027, China.
Xin
Wen-Feng
WF
Wang
Yi-Ming
YM
Luo
Guo-An
GA
Cheng
Yi-Yu
YY
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D016000:Cluster Analysis; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D007267:Injections; D008027:Light; D008419:Materia Medica / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011786:Quality Control; D012542:Scattering, Radiation
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; C504928:Qingkailing