Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis.
BACKGROUND
This study was conducted to determine the component that causes the disease in rheumatoid arthritis (RA), which shows great resemblance to periodontitis in a pathologic context.


METHODS
Within this study, the pathogen-specific IgG levels formed against Porphyromonas gingivalis FDC 381, Prevotella melaninogenica ATCC 25845, Actinobacillus actinomycetemcomitans Y4, Bacteroides forsythus ATCC 43047, and Prevotella intermedia 25611 oral bacteria were researched from the blood serum samples of 30 RA patients and 20 healthy controls with the enzyme-linked immunosorbent assay (ELISA) method.


RESULTS
The IgG levels of P gingivalis, P intermedia, P melaninogenica, and B forsythus were found to be significantly higher in RA patients when compared with those of the controls. Of the other bacteria antibodies, A actinomycetemcomitans was not found at greater levels in RA serum samples in comparison with the healthy samples.


CONCLUSIONS
The antibodies formed against P gingivalis, P intermedia, P melaninogenica, and B forsythus could be important to the etiopathogenesis of RA.
Ogrendik
Mesut
M
Department of Physical Medicine and Rehabilitation, Nazilli State Hospital, Nazilli, Aydin, Turkey. yaseminogrendik@superonline.com
Kokino
Siranus
S
Ozdemir
Ferda
F
Bird
Philip S
PS
Hamlet
Stephen
S
D000907:Antibodies, Bacterial / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000382:microbiology*; D001315:Australia; D001421:Bacteria, Anaerobic / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000276:immunology* / Q000382:microbiology*; D014421:Turkey
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G