Mitsunobu dehydration of N-Boc neomycin B.
Reaction of hexa-N-Boc neomycin B with TPP and DIAD in toluene results in the formation of an epoxide in ring IV, not an aziridine or azetidine as previously reported.
Quader
Sabina
S
Eskitis Institute, Griffith University, Nathan, Brisbane, QLD, Australia 4111.
Boyd
Sue E
SE
Jenkins
Ian D
ID
Houston
Todd A
TA
D004852:Epoxy Compounds / Q000138:chemical synthesis; D005563:Formic Acid Esters; D005601:Framycetin / Q000737:chemistry*; D007202:Indicators and Reagents; D014050:Toluene; D014867:Water / Q000737:chemistry*
D004852:Epoxy Compounds; D005563:Formic Acid Esters; D007202:Indicators and Reagents; C000345:t-butyloxycarbonyl group; D014867:Water; D014050:Toluene; D005601:Framycetin