title: Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample.
abstract: Intelligence, as measured by standardized psychological tests, has been shown to be highly heritable, though identifying specific genes influencing general intelligence has proven difficult. We conducted genome-wide linkage analyses to identify chromosomal regions containing genes influencing intelligence, as measured by WAIS full-scale IQ (FSIQ), performance IQ (PIQ) and verbal IQ (VIQ). Non-parametric multipoint linkage analyses were conducted with Merlin-regress software, using a sample of 1,111 genotyped and phenotyped individuals from 201 families, ascertained as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The strongest evidence of linkage was obtained for FSIQ on chromosome 6 (LOD=3.28, 12 cM) near the marker D6S1006. This region was also implicated with suggestive linkage in a recently published genome screen of IQ in Australian and Dutch twin pairs, and it has been implicated in linkage studies of developmental dyslexia. Our findings provide further support that chromosome 6p contains gene(s) affecting intelligence.
authors.affiliation: Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA. dickd@psychiatry.wustl.edu
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
authors.forename: Fazil
authors.initials: F
authors.lastname: Aliev
authors.forename: Laura
authors.initials: L
authors.lastname: Bierut
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
authors.forename: John
authors.initials: J
authors.lastname: Rice
authors.forename: Anthony
authors.initials: A
authors.lastname: Hinrichs
authors.forename: Sarah
authors.initials: S
authors.lastname: Bertelsen
authors.forename: Jen C
authors.initials: JC
authors.lastname: Wang
authors.forename: Gerald
authors.initials: G
authors.lastname: Dunn
authors.forename: Sam
authors.initials: S
authors.lastname: Kuperman
authors.forename: Marc
authors.initials: M
authors.lastname: Schuckit
authors.forename: John
authors.initials: J
authors.lastname: Nurnberger
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Henri
authors.initials: H
authors.lastname: Beglieter
authors.forename: John
authors.initials: J
authors.lastname: Kramer
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002886:Chromosomes, Human, Pair 17; D002896:Chromosomes, Human, Pair 6; D005190:Family; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D007361:Intelligence Tests; D008126:Lod Score
chemical_list: D005819:Genetic Markers