The effects of systemic administration of selective antagonists of dopamine D1 and D2/D3 receptors on food-related and defensive (escape responses) conditioned paw-placing responses in cats.
Experiments were performed on cats to study the effects of systemic administration of antagonists of dopaminergic transmission on food-related and defensive (an escape response) operant conditioned reflexes acquired on the basis of the innate response of placing the forepaw on a support. Selective blockade of D1 receptors with SCH23390 (0.005-0.1 mg/kg) completely and selective blockade of D2/D3 receptors with raclopride (0.1-0.25 mg/kg) partially suppressed both reflexes. At these doses, both blockers had stronger actions on the defensive conditioned escape reflex than the food-related reflex: SCH23390 had significantly stronger inhibitory effects on both reflexes than raclopride.
Maiorov
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Department of Higher Nervous Activity, M. V. Lomonosov Moscow State University. maiorov@protein.bio.msu.ru
Frolov
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AG
D000818:Animals; D001552:Benzazepines / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D018492:Dopamine Antagonists / Q000008:administration & dosage; D065127:Dopamine D2 Receptor Antagonists; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005528:Foot / Q000294:innervation / Q000502:physiology; D020891:Raclopride / Q000008:administration & dosage*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors*
D001552:Benzazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D050637:Receptors, Dopamine D3; D020891:Raclopride