Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks.
Molecular chaperones (heat shock proteins) are important components of cellular networks, such as protein-protein and gene regulatory networks. Chaperones participate in the folding of immunologically important proteins, presentation of antigens and activation of the immune system. Here, we propose that chaperone-related immune dysfunction might be more general than was previously thought. Mutations and polymorphism of chaperones and the regulators of their synthesis, heat shock factor-1, chaperone diseases, sick chaperones and chaperone overload might all affect (mostly impairing) immune responses.
Nardai
Gábor
G
Department of Medical Chemistry, Semmelweis University, H-1088 Budapest, Hungary.
Végh
Eszter M
EM
Prohászka
Zoltán
Z
Csermely
Péter
P
D000818:Animals; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011485:Protein Binding
D018832:Molecular Chaperones