title: [Clinical analysis of bladder cancer patients undergoing radical cystectomy].
abstract: A retrospective clinicopathological study was performed on 96 bladder cancer patients who underwent radical cystectomy and pelvic lymphadenectomy at Aichi Cancer Center between April 1994 and July 2004. The follow-up period ranged from 4 to 109 months, with a mean of 39.1 months. The overall cancer-specific survival rates at 3, 5 and 7 years were 81.7%, 71.2% and 71.2%, respectively. The 5-year survival rate according to pathological stage was 97.3% for pT1 or lower, 66.4% for pT2, 47.6% for pT3, and 25.4% for pT4. Univariate analysis demonstrated the prognostic significance of pathological stage (p < 0.001), lymph node metastasis (p = 0.001), venous invasion (p < 0.001), lymphatic invasion (p = 0.010), preoperative creatinine clearance (p = 0.001) and preoperative hydronephrosis (p < 0.001). Multivariate analysis revealed strong independent correlations of venous invasion (p = 0.040) and preoperative hydronephrosis (p = 0.016) with prognosis.
authors.affiliation: The Department of Urology, Aichi Cancer Center.
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Kato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Wakita
authors.forename: Norio
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy / Q000401:mortality*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020360:Neoadjuvant Therapy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*