[Effect of Jingjielianqiao decoction on healing of skin ulcer in rats].
OBJECTIVE
To study the pharmacodynamics of Jingjielianqiao decoction in promoting the healing of skin ulcer in mice.


METHODS
Mouse models of skin ulcer were established by inducing skin trauma and scald, respectively. The skin ulcer of the mice was treated with Jingjielianqiao decoction or recombinant human epithelial growth factor (rhEGF), and the ulcer area after treatment was compared between the two groups and with their respective self control. Inflammatory cell infiltration in the ulcer was observed under the microscope.


RESULTS
Compared with the self-control group, the skin ulcer area of mice treated with Jingjielianqiao decoction was reduced obviously (P<0.001), and the inflammatory cell infiltration also alleviated (P<0.001). Jingjielianqiao decoction produced significantly better therapeutic effect than rhEGF.


CONCLUSIONS
Jingjielianqiao decoction can obviously improve the healing of skin ulcer in mice with better effect than rhEGF.
Liu
Xue-qing
XQ
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lxqin333@163.com
Zeng
Kang
K
Lan
Hai-mei
HM
Chen
Bao-tian
BT
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D012883:Skin Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
D004365:Drugs, Chinese Herbal