Palladium-catalyzed asymmetric amination and imidation of 2,3-allenyl phosphates.
[reaction: see text] Asymmetric amination of 2,3-allenyl phosphates with nitrogen nucleophiles such as amines, hydroxylamines, and imides can be performed efficiently using a combination of zerovalent palladium complexes and SEGPHOS or MeOBIPHEP ligand, affording the corresponding optically active 1-aminated derivatives with enantiomeric excess of up to 97% ee.
Imada
Yasushi
Y
Department of Chemistry, Graduate School of Engineering Science, Osaka University Machikaneyama, Toyonaka, Osaka 560-8531, Japan. imada@chem.es.osaka-u.ac.jp
Nishida
Masayuki
M
Kutsuwa
Koji
K
Murahashi
Shun-Ichi
S
Naota
Takeshi
T