title: The prevalence of metabolic syndrome in patients with gout: a multicenter study.
abstract: It has been suggested that hyperuricemia and possibly gout are associated with the metabolic syndrome, but there have been no direct studies. This study was undertaken to obtain the prevalence of the metabolic syndrome in patients with gout and to compare it with those from the general population studies. This was a 4-institutional case-historical control study composed of 168 patients with gout. We assessed the prevalence of metabolic syndrome according to the ATP III criteria and compared the prevalence with that of the historical controls. To elucidate the factors in gout that were associated with metabolic syndrome, a multivariate analysis was done. The age-adjusted prevalence of metabolic syndrome in gout patients was 43.6%, which was significantly higher than that of the Korean control population (5.2%) from the previous studies. Patients with gout had more components of metabolic syndrome than did the controls. Body mass index (BMI, OR = 1.357 (95%CI 1.111-1.657)) and high density lipoprotein (HDL, OR = 0.774 (95%CI 0.705-0.850)) were the variables most significantly associated with the occurrence of metabolic syndrome in gout, but alcohol consumption did not show such associations. Gout is associated with the metabolic syndrome, and furthermore, obesity and dyslipidemia were the factors most associated with the syndrome in these patients.
authors.affiliation: Division of Rheumatology, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Rho
authors.forename: Seong Jae
authors.initials: SJ
authors.lastname: Choi
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Jong Dae
authors.initials: JD
authors.lastname: Ji
authors.forename: Kyung Mook
authors.initials: KM
authors.lastname: Choi
authors.forename: Sei Hyun
authors.initials: SH
authors.lastname: Baik
authors.forename: Seung-hie
authors.initials: SH
authors.lastname: Chung
authors.forename: Chae-Gi
authors.initials: CG
authors.lastname: Kim
authors.forename: Jung-Yoon
authors.initials: JY
authors.lastname: Choe
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Won Tae
authors.initials: WT
authors.lastname: Chung
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D006073:Gout / Q000150:complications*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D008075:Lipoproteins, HDL