Predicting the sites of metastases.
Transplantation of human breast cancer cells into immunodeficient mice together with gene-expression microarray studies has recently identified genes implicated in the tissue tropism of breast-cancer metastasis. Such signatures of site-specific metastatic capabilities might allow the targeting of therapy to likely sites of metastasis.
Ring
Brian Z
BZ
Applied Genomics Inc, 525 Del Rey Avenue, Sunnyvale, CA 94085, USA. bzring@applied-genomics.com
Ross
Douglas T
DT
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D009928:Organ Specificity