Sinonasal leiomyosarcoma: review of literature and case report.
OBJECTIVE
To determine prognosis of primary sinonasal leiomyosarcomas after treatment.


METHODS
Literature review and case report.


METHODS
Review of English literature from MEDLINE and independent sources with the addition of our case.


RESULTS
Including our case, 63 cases have been reported. Primary treatment includes resection with or without radiation. Chemotherapy has not been reported to be effective. In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly. On the basis of a review of all reported cases, the overall survival rate at a mean follow-up of 38.24 month is 66%. The minimal overall survival rates at 5 and 10 years are 20% and 6%, respectively.


CONCLUSIONS
The prognosis for primary sinonasal leiomyosarcomas is poor. However, a 10-year survival has been reported in a few patients. Chemotherapy may be a useful adjunct when managing extensive lesions unamenable to curative resection.
Ulrich
Christian T
CT
Feiz-Erfan
Iman
I
Spetzler
Robert F
RF
Isaacs
Jeffrey D
JD
Hott
Jonathan S
JS
Nakaji
Peter
P
Coons
Stephen W
SW
Joganic
Edward J
EJ
Kresl
John J
JJ
Milligan
John M
JM
Lettieri
Salvatore C
SC
D000328:Adult; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D009669:Nose Neoplasms / Q000473:pathology*; D010256:Paranasal Sinuses / Q000473:pathology*; D012720:Severity of Illness Index