title: Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition.
abstract: Drug efflux pumps belong to a large family of ATP-binding cassette transporter proteins. These pumps bind their substrate and export it through the membrane using energy derived from ATP hydrolysis. P-glycoprotein, the main efflux pump in this family, is expressed not only in tumour cells but also in normal tissues with excretory function (liver, kidney and the intestine). It has a broad specificity of substrates and plays an important role in drug delivery and disposition. Recently, genetic screening of P-glycoprotein has yielded multiple single nucleotide polymorphisms, which seem to alter transporter function and expression. This review discusses the various polymorphisms of this gene and its impact on drug disposition and diseases.
authors.affiliation: College of Pharmacy, University of Southern Nevada, 11 Sunset Way, Henderson, NV 89014, USA. sdey@usn.edu
authors.forename: Surajit
authors.initials: S
authors.lastname: Dey
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D044466:Asian People; D001682:Biological Availability; D044383:Black People; D016503:Drug Delivery Systems; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004364:Pharmaceutical Preparations