title: Familial interstitial lung disease in two young Korean sisters.
abstract: Most of the interstitial lung diseases are rare, chronic, progressive and fatal disorders, especially in familial form. The etiology of the majority of interstitial lung disease is still unknown. Host susceptibility, genetic and environmental factors may influence clinical expression of each disease. With familial interstitial lung diseases, mutations of surfactant protein B and surfactant protein C or other additional genetic mechanisms (e.g. mutation of the gene for ATP-binding cassette transporter A3) could be associated. We found a 21 month-old girl with respiratory symptoms, abnormal radiographic findings and abnormal open lung biopsy findings compatible with nonspecific interstitial pneumonitis that is similar to those of her older sister died from this disease. We performed genetic studies of the patient and her parents, but we could not find any mutation in our case. High-dose intravenous methylprednisolone and oral hydroxychloroquine were administered and she is still alive without progression during 21 months of follow-up.
authors.affiliation: Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hyo-Bin
authors.initials: HB
authors.lastname: Kim
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Lee
authors.forename: Ja-Hyung
authors.initials: JH
authors.lastname: Kim
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Jang
authors.forename: Jooryung
authors.initials: J
authors.lastname: Huh
authors.forename: Seong-Jong
authors.initials: SJ
authors.lastname: Park
authors.forename: Soo-Jong
authors.initials: SJ
authors.lastname: Hong
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage; D007223:Infant; D007723:Korea; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008775:Methylprednisolone / Q000008:administration & dosage; D035781:Siblings; D014057:Tomography, X-Ray Computed
chemical_list: D006886:Hydroxychloroquine; D008775:Methylprednisolone