title: Improving hollow fiber dialyzer efficiency with a recirculating dialysate system II: comparison against two-chamber dialysis systems.
abstract: The theoretical basis of the nonregenerated recirculating dialysate system (RDS) was derived in Part I of this work [M. Prado, L. M. Roa, A. Palma, and J. A. Milán, Ann. Biomed. Eng. (2005)]. This system pursues the maximization of the clearance of hollow fiber dialyzers whose performance is controlled by diffusion, as occurred in standard hemodialysis. In this second part we perform a comparison by digital simulation of the RDS against three well-known two-chamber dialysis systems. As a major outcome, the efficiency of the RDS increased by a factor of five-eight with respect to the efficiency of a single dialyzer operating with a number of transfer units equal to 0.1, that is when the diffusive mass-transfer of the dialyzer is exhausted. Present low-flux dialyzers do not take advantage of the full potential of this technique, but the functional domain where high-flux and high-area dialyzers operate could be more suitable to exploit this technique. We conclude that RDS can be a competitive efficient technique for optimizing the dialysis efficiency.
authors.affiliation: Biomedical Engineering Group, University of Seville, Seville, Spain. mpradovelasco@ieee.org
authors.forename: Manuel
authors.initials: M
authors.lastname: Prado
authors.forename: Laura M
authors.initials: LM
authors.lastname: Roa
authors.forename: Alfonso
authors.initials: A
authors.lastname: Palma
authors.forename: José A
authors.initials: JA
authors.lastname: Milán
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008567:Membranes, Artificial; D008956:Models, Chemical; D006435:Renal Dialysis; D014462:Ultrafiltration
chemical_list: D008567:Membranes, Artificial