title: SNEP: SNP-derived epitope prediction program for minor H antigens.
abstract: The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIANT or CONFLICT in SWISS-PROT) and predicts potential T-cell epitopes within a chosen distance around the polymorphic residue. The prediction algorithm is based on the SYFPEITHI T-cell epitope prediction program. SNEP is able to search for proteins according to their accession numbers, sequence stretches or gene names, for example. The predictions are available for several human leucocyte antigen class I and class II allelic products, which allow for a rapid and precise evaluation of potential miHAgs within polymorphic antigens.
authors.affiliation: Abteilung Immunologie, Interfakultäres Institut für Zellbiologie, Universität Tübingen, Germany.
authors.forename: Mathias M
authors.initials: MM
authors.lastname: Schuler
authors.forename: Pierre
authors.initials: P
authors.lastname: Dönnes
authors.forename: Maria-Dorothea
authors.initials: MD
authors.lastname: Nastke
authors.forename: Oliver
authors.initials: O
authors.lastname: Kohlbacher
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Rammensee
authors.forename: Stefan
authors.initials: S
authors.lastname: Stevanovic
mesh_terms: D000595:Amino Acid Sequence; D003627:Data Interpretation, Statistical; D030562:Databases, Protein; D018984:Epitopes, T-Lymphocyte / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D012984:Software
chemical_list: D018984:Epitopes, T-Lymphocyte; D006680:HLA Antigens; D015778:Minor Histocompatibility Antigens