title: Detection of QTL for innate: non-specific antibody levels binding LPS and LTA in two independent populations of laying hens.
abstract: In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry.
authors.affiliation: Animal Breeding and Genetic Groups, Wageningen University, Wageningen, The Netherlands. siwek@atr.bydgoszcz.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Siwek
authors.forename: Bart
authors.initials: B
authors.lastname: Buitenhuis
authors.forename: Sandra
authors.initials: S
authors.lastname: Cornelissen
authors.forename: Mike
authors.initials: M
authors.lastname: Nieuwland
authors.forename: Egbert F
authors.initials: EF
authors.lastname: Knol
authors.forename: Richard
authors.initials: R
authors.lastname: Crooijmans
authors.forename: Martien
authors.initials: M
authors.lastname: Groenen
authors.forename: Henk
authors.initials: H
authors.lastname: Parmentier
authors.forename: Jan
authors.initials: J
authors.lastname: van der Poel
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000235:genetics; D002645:Chickens / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000276:immunology*; D013682:Teichoic Acids / Q000276:immunology
chemical_list: D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid