High incidence of Hb D-Los Angeles [beta121(GH4)Glu-->Gln] in Denizli Province, Aegean region of Turkey.
Denizli Province is located in the inner part of the Aegean region of Turkey and is one of the target areas for premarital screening. Here we report the abnormal hemoglobins (Hbs) observed during a premarital screening program in our region. According to our results, Hb D-Los Angeles [beta1211(GH4)Glu-->Gln (GAA-->CAA] (also known as D-Punjab, D-North Carolina, D-Portugal, Oak Ridge and D-Chicago), is the most frequent abnormal Hb in this region.
Atalay
Erol O
EO
Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey. eatalay@pamukkale.edu.tr
Koyuncu
Hasan
H
Turgut
Berna
B
Atalay
Ayfer
A
Yildiz
Sanem
S
Bahadir
Anzel
A
Köseler
Aylin
A
D005787:Gene Frequency; D005820:Genetic Testing; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D015994:Incidence; D017720:Molecular Epidemiology; D011291:Premarital Examinations; D014421:Turkey / Q000453:epidemiology
D006455:Hemoglobins, Abnormal; C032001:hemoglobin D; C026237:hemoglobin D Punjab