title: A comparison of viral RNA-dependent RNA polymerases.
abstract: Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg, to initiate RNA replication. The recent explosion of structural information on picornaviral 3D polymerases has provided insights into the initiation of RNA synthesis and chain elongation. Comparing these data with results from previous structural analyses of viral RNA-dependent RNA polymerases that catalyze de novo RNA synthesis sheds light on the different strategies that these viruses use to initiate replication.
authors.affiliation: Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Josep Samitier 1-5, E-08028 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ferrer-Orta
authors.forename: Armando
authors.initials: A
authors.lastname: Arias
authors.forename: Cristina
authors.initials: C
authors.lastname: Escarmís
authors.forename: Nuria
authors.initials: N
authors.lastname: Verdaguer
mesh_terms: D010849:Picornaviridae / Q000201:enzymology* / Q000235:genetics*; D012367:RNA, Viral / Q000502:physiology*; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry* / Q000235:genetics*
chemical_list: D012367:RNA, Viral; D012324:RNA-Dependent RNA Polymerase