Role of fetal ultrasound and magnetic resonance imaging in the prenatal diagnosis of migration disorders.
OBJECTIVE
To evaluate the contribution and limitations of fetal ultrasonography (US) and magnetic resonance imaging (MRI) for the diagnosis and management of migration disorders.


METHODS
Over a 5-year period, 14 fetuses with pathological migration disorders, without an infectious context, were taken care of in our centre. All underwent US; nine underwent MRI as well. Sonographic and MRI data were compared with neuropathological data.


RESULTS
The diagnosis of gyral disorders was obtained by US in 1/14 cases; other cerebral abnormalities were found suggesting neuronal disorder in the remainder. Cerebral MRI suggested gyral abnormality in eight of the nine cases.


CONCLUSIONS
US performance is increasing. MRI appears to be a promising method for the diagnosis of fetal migration disorders, giving better results than US. It may be recommended in cases of abnormal cerebral US findings or familial clinical history. However, interpretation of MRI can be tricky and the resulting diagnosis occurs late within the pregnancy.
Rubod
Chrystèle
C
Clinique de Gynécologie Obstétrique, Hôpital Jeanne de Flandre, CHRU de Lille, France.
Robert
Yann
Y
Tillouche
Nadia
N
Devisme
Louise
L
Houfflin-Debarge
Véronique
V
Puech
Francis
F
D002540:Cerebral Cortex / Q000002:abnormalities* / Q000196:embryology; D002869:Chromosome Aberrations; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D005865:Gestational Age; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000295:instrumentation / Q000379:methods*; D016216:Ultrasonography, Prenatal / Q000295:instrumentation*