Microbial transformation of macrocyclic trichothecenes.
A resting culture of Rhizopus arrhizus (ATCC 11145) transformed verrucarin A into 16-hydroxyverrucarin A, whereas R. arrhizus transformed verrucarin B into a mixture of 16-hydroxyverrucarin B and 3'-hydroxyverrucarin A. Relative to verrucarins A and B, the 16-hydroxy derivatives showed marked increases in activity, as tested in vivo against P388 mouse leukemia.
Pavanasasivam
G
G
Department of Chemistry, University of Maryland, College Park, Maryland 20742.
Jarvis
B B
BB