title: Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence.
abstract: The HtrA serine protease has been shown to be essential for bacterial virulence and for survival after exposure to many types of environmental and cellular stresses. A Listeria monocytogenes 10403S htrA mutant was found to be sensitive to oxidative and puromycin-induced stress at high temperatures, showed a reduced ability to form biofilms, and was attenuated for virulence in mice.
authors.affiliation: SIGA Technologies, 4575 NW Research Way, Corvallis, OR 97330, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Wilson
authors.forename: Lindsay L
authors.initials: LL
authors.lastname: Brown
authors.forename: Dana
authors.initials: D
authors.lastname: Kirkwood-Watts
authors.forename: Travis K
authors.initials: TK
authors.lastname: Warren
authors.forename: S Amanda
authors.initials: SA
authors.lastname: Lund
authors.forename: David S
authors.initials: DS
authors.lastname: King
authors.forename: Kevin F
authors.initials: KF
authors.lastname: Jones
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Hruby
mesh_terms: D000818:Animals; D018441:Biofilms; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics*; D006358:Hot Temperature; D008089:Listeria monocytogenes / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000472:pathogenicity; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000502:physiology*; D033903:Periplasmic Proteins / Q000235:genetics*; D011691:Puromycin / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000235:genetics*; D014774:Virulence / Q000235:genetics
chemical_list: D006360:Heat-Shock Proteins; D033903:Periplasmic Proteins; D011691:Puromycin; C061682:DegP protease; D012697:Serine Endopeptidases