title: Analgesic drug use and risk of ovarian cancer.
abstract: BACKGROUND
  Previous epidemiologic research suggests that analgesic use may reduce the risk of ovarian cancer, although results are not consistent.
  
  
  METHODS
  In a population-based, case-control study, we analyzed data from 586 ovarian cancer cases and 627 matched controls in North Carolina for the relationship between analgesic use and ovarian cancer risk. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) while adjusting for potential confounders.
  
  
  RESULTS
  Use of any nonsteroidal antiinflammatory drugs, including aspirin, within 5 years of diagnosis/interview was found to be associated with a reduction in the risk of ovarian cancer (adjusted OR = 0.72; 95% CI = 0.56-0.92). For use of acetaminophen, the OR was 0.78 (95% CI = 0.56-1.08).
  
  
  CONCLUSIONS
  These data support an inverse relationship between the use of both nonsteroidal antiinflammatory drugs and acetaminophen and the risk of ovarian cancer.
authors.affiliation: Duke Comprehensive Cancer Center, Cancer Prevention, Detection and Control Research Program, Duke University Medical Center, Durham, North Carolina 27710, USA. schil001@mc.duke.edu
authors.forename: Joellen M
authors.initials: JM
authors.lastname: Schildkraut
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Moorman
authors.forename: Susan
authors.initials: S
authors.lastname: Halabi
authors.forename: Brian
authors.initials: B
authors.lastname: Calingaert
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Marks
authors.forename: Andrew
authors.initials: A
authors.lastname: Berchuck
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006801:Humans; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen