Treatment of NSCLC patients with an EGF-based cancer vaccine: report of a Phase I trial.
Epidermal Growth Factor (EGF) promotes tumor cell proliferation and survival upon binding to its receptor. We have developed a new active specific immunotherapy based on EGF deprivation. In the present paper, we show the results of a Phase I trial in 43 patients with advanced non-small cell lung cancer (NSCLC) who received the EGF vaccine. Patients who had already received first line therapy were randomized to receive a single or double dose of the EGF vaccine, weekly for four weeks and monthly thereafter. No significant toxicity was seen after vaccination. Adverse events consisted primarily of fever, chills, nausea, vomiting and flushing. Fifteen patients (39%) developed a good antibody response (GAR) against EGF. The geometric mean of the antibody titer was higher in the double dose group. EGF concentration was quantified in serum. An inverse correlation between anti-EGF antibody titers and EGF concentration was seen after immunization. Vaccinated patients achieved median survival times of 8.23 months from randomization. Patients who received the double dose of treatment showed a trend toward increased survival in comparison with patients who received the single dose. GAR and patients in whom the serum EGF decreased below the 168 pg/ml cut-off point had a significantly better survival when compared to poor responders or patients in which the EGF levels were not considerably reduced. Our results confirm the immunogenicity of the EGF vaccine in the treatment of patients with advanced stage NSCLC. Antibody titers and serum EGF levels appear to correlate with patient survival.
Ramos
Tania Crombet
TC
Center of Molecular Immunology, Havana, Cuba. Taniac@ict.cim.sld.cu
Vinageras
Elia Neninger
EN
Ferrer
Mauricio Catalá
MC
Verdecia
Beatriz García
BG
Rupalé
Idrissa Leonard
IL
Pérez
Liana Martínez
LM
Marinello
Gisela González
GG
Rodríguez
Rolando Pérez
RP
Dávila
Agustín Lage
AL
D000368:Aged; D000906:Antibodies / Q000097:blood; D019496:Cancer Vaccines / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D004815:Epidermal Growth Factor / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D016233:Immunotherapy, Active; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D019496:Cancer Vaccines; D004815:Epidermal Growth Factor