[Extracapsular spread as an ominous prognostic sign in laryngeal cancer].
OBJECTIVE
Impact of extracapsular spread upon survival and recurrence rates in patients with laryngeal cancer.


METHODS
Retrospective analysis of 309 patients with pathologically confirmed regional metastases with and without extracapsular spread (144 and 165 patients respectively). To examine impact of clinical variables upon treatment outcomes we used logistic regression (logit) and Kaplan-Meier method to calculate 5-years disease free survival.


RESULTS
Extracapsular spread significantly reduced 5-years survival (40% vs 77%; p = 0.005) and increased regional recurrence rates (33% vs 12%; p = 0.0001).


CONCLUSIONS
Authors suggest use of radiotherapy after neck dissection in presence of extracapsular spread.
Wachulski
Bartosz
B
Klinika Otolaryngologii CMKP, Szpital Bródnowski, Warszawa.
Osmólski
Antoni
A
Osmólski
Robert
R
Forlot
Joanna
J
D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors