[Clinical observation on effect of huoxue jieyu decoction in treating depression after craniotomy: a report of 45 cases].
OBJECTIVE
To observe the therapeutic effect of Huoxue Jieyu decoction (HJD) on patients with depression after craniotomy.


METHODS
Ninety patients were randomly divided into 2 groups according to the sequence of their consultation. The 45 patients in the treated group were treated with conventional symptomatic treatment plus oral administration of HJD, and the 38 patients in the control group were treated in the same way but with chlorimipramine (anafranil) instead of HJD. Hamilton depression (HAMD) scores before and after treatment, occurrence of adverse effects and long-term therapeutic effect of treatment were observed.


RESULTS
The score of HAMD was insignificantly different in 2 groups before and after treatment (P >0.05), but the occurrence of adverse effects between them was significantly different (P < 0.01).


CONCLUSIONS
The therapeutic effect of HJD on depression was similar to that of anafranil, but HJD has less adverse effect and more stabilized long-term effect.
Zhou
Ning-quan
NQ
Department of Brain Surgery, Qiannan Prefacture People's Hospital, Guizhou.
Song
Zhen-xing
ZX
Tian
Wei-lin
WL
D000293:Adolescent; D000328:Adult; D003399:Craniotomy / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011183:Postoperative Complications / Q000188:drug therapy
D004365:Drugs, Chinese Herbal