title: Evaluation of the effect of multiple-dose administration of R411, a dual alpha4beta1-alpha4beta7 integrin antagonist on the major CYP isoform activities in healthy volunteers.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Hijazi
authors.forename: Horst
authors.initials: H
authors.lastname: Welker
authors.forename: Albert E
authors.initials: AE
authors.lastname: Dorr
authors.forename: Karl
authors.initials: K
authors.lastname: Frank
authors.forename: Louis M
authors.initials: LM
authors.lastname: Renzetti
authors.forename: Indravadan
authors.initials: I
authors.lastname: Patel
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D018592:Cross-Over Studies; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D039441:Integrin alpha4 / Q000378:metabolism*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism
chemical_list: D039441:Integrin alpha4; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6