title: Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study.
abstract: We used a newly reported regional homogeneity approach to measure the temporal homogeneity of blood oxygen level-dependent signal for exploring the brain activity of schizophrenia in a resting state. The results showed decreased regional homogeneity in schizophrenia, which distributed over the bilateral frontal, temporal, occipital, cerebellar posterior, right parietal and left limbic lobes, similar to the findings reported in previous resting state functional studies. The brain regions that showed decreased regional homogeneity are believed to be involved in the psychopathology and pathophysiology of schizophrenia. Our results indicate that abnormal brain activity of schizophrenia may exist in a resting state and the regional homogeneity may be potentially helpful in understanding the resting state of schizophrenia.
authors.affiliation: Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Haihong
authors.initials: H
authors.lastname: Liu
authors.forename: Zhening
authors.initials: Z
authors.lastname: Liu
authors.forename: Meng
authors.initials: M
authors.lastname: Liang
authors.forename: Yihui
authors.initials: Y
authors.lastname: Hao
authors.forename: Lihua
authors.initials: L
authors.lastname: Tan
authors.forename: Fan
authors.initials: F
authors.lastname: Kuang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Yi
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D012146:Rest / Q000502:physiology*; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D010100:Oxygen