title: Toxicology screening in orthopedic trauma patients predicting duration of prescription opioid use.
abstract: Following hospitalization for orthopedic trauma, some patients continue to use opioids following fracture healing. This retrospective cohort study of 50 patients with high-energy fractures was conducted to determine if toxicology screening tests upon admission can predict subsequent opioid use. Data were collected from clinical records and a statewide electronic database of prescription records. Six months following hospital discharge, those with positive toxicology used more Following hospitalization for orthopedic trauma, some patients continue to use opioids following fracture healing. This retrospective cohort study of 50 patients with high-energy fractures was conducted to determine if toxicology screening tests upon admission can predict subsequent opioid use. Data were collected from clinical records and a statewide electronic database of prescription records. Six months following hospital discharge, those with positive toxicology used more. Following hospitalization for orthopedic trauma, some patients continue to use opioids following fracture healing. This retrospective cohort study of 50 patients with high-energy fractures was conducted to determine if toxicology screening tests upon admission can predict subsequent opioid use. Data were collected from clinical records and a statewide electronic database of prescription records. Six months following hospital discharge, those with positive toxicology used more opioids (730 mg vs. 364 mg; P = .04) expressed as morphine equivalents than those with negative toxicology and were more likely to continue using opiates at the end of the 3rd, 4th, 5th, and 6th month after discharge. Patients hospitalized for high-energy fractures with positive admission toxicology are at risk for prolonged opiate use during the initial six months following discharge.
authors.affiliation: Department of Orthopedic Surgery, University of Louisville, School of Medicine, KY, USA.
authors.forename: Gene M
authors.initials: GM
authors.lastname: Massey
authors.forename: Heather N
authors.initials: HN
authors.lastname: Dodds
authors.forename: Craig S
authors.initials: CS
authors.lastname: Roberts
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Servoss
authors.forename: Richard D
authors.initials: RD
authors.lastname: Blondell
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D015331:Cohort Studies; D003710:Demography; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D050723:Fractures, Bone / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D009985:Orthopedics / Q000706:statistics & numerical data*; D010149:Postoperative Pain / Q000188:drug therapy* / Q000453:epidemiology*; D012189:Retrospective Studies; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000097:blood / Q000453:epidemiology* / Q000652:urine; D013997:Time Factors; D014116:Toxicology / Q000379:methods*
chemical_list: D000701:Analgesics, Opioid