Association between primary Sjögren's syndrome and non-Hodgkin's lymphoma.
Sjögren's Syndrome (SS) is one of the most frequent autoimmune disorders, which affects approximately 1% of the population. It occurs in patients of all ages, but especially females during the fourth and fifth decades of life with a female/male ratio of 9:1. The main target of this disease are the exocrine glands that are infiltrated progressively by lymphocytes and finally destroyed, leading to decreased exocrine secretion. Thus primary SS is usually defined as xerophtalmia (dry eye) and xerostomia (dry mouth) accompanied in 60% of cases by parotid swelling [1]. The most serious complication of Sjögren's Syndrome is the high risk of the occurrence of non-Hodgkin's Lymphoma.
Opriş
Daniela
D
"Carol Davila" University of Medicine and Pharmacy, Department of Rheumatology and Internal Medicine, "St. Maria" Hospital, Bucharest, Romania. DanaO@xnet.ro
Iosif
Cristina-Ileana
CI
Predeţeanu
Denisa
D
D001706:Biopsy; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis