title: Plasmodium falciparum transmission blocking immunity in three areas with perennial or seasonal endemicity and different levels of transmission.
abstract: Plasmodium falciparum transmission blocking immunity (TBI) was investigated in 3 different endemic areas. Reared Anopheles gambiae s.s. were experimentally infected with the blood of gametocyte carriers, either in the presence of autologous plasma (OWN) or after replacement of the OWN plasma with a nonimmune serum of AB blood group (control). Transmission reduction was defined by a lower level of mosquito infection in the OWN batch compared with the control. After controlling for the effect of gametocytemia, the proportion of "transmission reducers" was lower in the town of Yaounde in Cameroon (UC), (14%, N = 75) than in the two rural areas of South Cameroon (RC) (29%, N = 31) and Sénégal (RS) (44%, N = 32). The contribution of TBI relative to the total inhibition of the parasite development (including human, parasite, and mosquito factors) was higher in RS (49.6%) than in RC (12.6%) and UC (9.5%).
authors.affiliation: Unité de Recherche 077, Institut de Recherche pour le Développement (IRD), Dakar, Sénégal. boudin@ird.sn
authors.forename: Christian
authors.initials: C
authors.lastname: Boudin
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Diop
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Gaye
authors.forename: Libasse
authors.initials: L
authors.lastname: Gadiaga
authors.forename: Clément
authors.initials: C
authors.lastname: Gouagna
authors.forename: Innocent
authors.initials: I
authors.lastname: Safeukui
authors.forename: Sarah
authors.initials: S
authors.lastname: Bonnet
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D002163:Cameroon / Q000453:epidemiology; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology / Q000635:transmission; D002648:Child; D003430:Cross-Sectional Studies; D019353:Endemic Diseases; D005260:Female; D005718:Gametogenesis; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology / Q000635:transmission*; D008297:Male; D010963:Plasmodium falciparum / Q000472:pathogenicity*; D012621:Seasons; D012675:Senegal / Q000453:epidemiology