title: Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture.
abstract: Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespiliformis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explain their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.
authors.affiliation: Laboratory of Physiological Animal, University of Ouagadougou BP 7021, Burkina Faso. rbelemtougri@voila.fr
authors.forename: R G
authors.initials: RG
authors.lastname: Belemtougri
authors.forename: B
authors.initials: B
authors.lastname: Constantin
authors.forename: C
authors.initials: C
authors.lastname: Cognard
authors.forename: G
authors.initials: G
authors.lastname: Raymond
authors.forename: L
authors.initials: L
authors.lastname: Sawadogo
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D031262:Ebenaceae / Q000737:chemistry*; D018485:Muscle Fibers, Skeletal / Q000187:drug effects* / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D031647:Psidium / Q000737:chemistry*; D051381:Rats
chemical_list: D010936:Plant Extracts; D002118:Calcium