title: Invasive group A streptococcal infection with pancarditis caused by a new emm-type 12 allele of Streptococcus pyogenes.
abstract: Throughout the 1980s, a progressive increase in the incidence of Streptococcus pyogenes-related invasive infections has occurred. It has been suggested that a host-related immunogenetic background, as well as bacterial virulence factors may play an important role in the outcome of streptococcal infections. Here, we present the first case of pancarditis in the literature caused by direct bacterial invasion due to a new emm-type 12 allele of S. pyogenes in an immunocompetent patient. The pathogenesis of this invasive infection, as well as predictors of poor prognosis are discussed.
authors.affiliation: Section of Infectious Diseases Unit, Hacettepe University School of Medicine, Ankara, Turkey. gozkayasahin@yahoo.com
authors.forename: Gülşen
authors.initials: G
authors.lastname: Ozkaya
authors.forename: Ali
authors.initials: A
authors.lastname: Shorbagi
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Ulger
authors.forename: Arzu
authors.initials: A
authors.lastname: Saglam
authors.forename: Melda
authors.initials: M
authors.lastname: Aybar
authors.forename: Yeşim Cetinkaya
authors.initials: YC
authors.lastname: Sardan
authors.forename: Omrüm
authors.initials: O
authors.lastname: Uzun
mesh_terms: D000328:Adult; D000483:Alleles; D000942:Antigens, Bacterial / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009205:Myocarditis / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology; D013290:Streptococcal Infections / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein