title: Fever due to aortitis.
abstract: We report a case of vasculitis with predominant aortic involvement. Vasculitis of large vessels has a limited number of tools for diagnosis and follow-up. A 78-year-old woman was referred to the internal medicine department with a 2-month history of fever of unknown origin (FUO), night sweats, weight loss and markedly elevated ESR and CRP. The results of an extended routine investigation found no infection, malignancy, hypersensitivity or autoimmune disorder. The patient did not suffer from claudication; systolic blood pressure difference between arms was 20 mm Hg. Temporal artery biopsies were negative. 2-18F-Fluorine-2-deoxy-D -glucose positron emission tomography (FDG PET) scan imaging demonstrated intense FDG uptake along the aorta and in the brachio-cephalic and carotid arteries consistent with arteritis. A high dose of corticosteroid therapy (1 mg/kg) was instituted with further tapering. The therapy was followed by complete resolution of the symptoms and pathological FDG uptake on repeated FDG PET. Second-line therapy was not added because of positive conversion of Mantaux test followed by rifampicin prophylaxis. FDG PET should be a part of the work-up of FUO when routine investigation fails to determine its etiology. FDG PET is useful both for diagnosis and assessment of response to therapy for large-vessel vasculitis.
authors.affiliation: B. Shine Department of Rheumatology, Rambam Medical Center and Rappaport Faculty of Medicine, Israel-Technion Institute of Technology, P.O. Box 9602, Haifa, 31096, Israel. a_rozin@rambam.health.gov.il
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Rozin
authors.forename: Rachel
authors.initials: R
authors.lastname: Bar-Shalom
authors.forename: Alexander
authors.initials: A
authors.lastname: Strizevsky
authors.forename: Giris
authors.initials: G
authors.lastname: Jacob
mesh_terms: D000368:Aged; D001011:Aorta / Q000000981:diagnostic imaging / Q000473:pathology*; D001025:Aortitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D016122:Brachiocephalic Trunk / Q000000981:diagnostic imaging / Q000473:pathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005335:Fever of Unknown Origin / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D049268:Positron-Emission Tomography; D011241:Prednisone / Q000627:therapeutic use; D019275:Radiopharmaceuticals; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D011241:Prednisone