title: The role of microarray technologies in the study of soft tissue tumours.
abstract: Array technologies (gene array, tissue microarray and others) are being used in a growing number of research projects involving soft tissue tumours. Gene array techniques allow for measurements of RNA expression levels or gene copy number changes for a large number of genes in a single specimen. A complementary technique, tissue microarrays, allows for the measurement of expression of a single gene in a large number of specimens. These techniques and similar ones have created a fundamentally new approach to the investigation of soft tissue tumours. This review addresses some of the advantages, problems, and solutions to those problems that come with these technologies.
authors.affiliation: Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA. mrijn@stanford.edu
authors.forename: R B
authors.initials: RB
authors.lastname: West
authors.forename: M
authors.initials: M
authors.lastname: van de Rijn
mesh_terms: D016000:Cluster Analysis; D020869:Gene Expression Profiling; D006801:Humans; D046228:Microarray Analysis / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000235:genetics