title: Serendipity strikes twice: the discovery and rediscovery of defective ribosomal products (DRiPS).
abstract: Here I recount how the remarkably large fraction of rapidly degraded nascent proteins was discovered through serendipity not once, but twice. This story is used as a canvas for discussing how the imperfections in human nature retard scientific progress.
authors.affiliation: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA. jyewdell@nih.gov
authors.forename: J W
authors.initials: JW
authors.lastname: Yewdell
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000266:history / Q000379:methods / Q000639:trends; D006367:HeLa Cells; D049673:History, 20th Century; D006801:Humans; D007107:Immune System / Q000502:physiology; D033183:Interdisciplinary Communication; D010455:Peptides / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D010455:Peptides; D011506:Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex