[The prevalence of E6/E7 HPV type 16 in laryngeal cancer and in normal mucosa].
Many authors suggest that HPV infection can play a great role in development of benign and malignant tumours of upper respiratory tract in human. The aim of this study was to determine the prevalence of E6/E7 HPV-16 in laryngeal squamous cell carcinoma, and normal laryngeal mucosa, and to analyse their correlation with sex, lymph node status, primary tumor stage, localization, and histological differentiation. HPV 16 DNA presence was analysed using PCR technique in 72 samples of laryngeal carcinoma and in samples of 50 normal mucosa. Human papillomavirus was detected in 26 (36.1%) of the 72 patients. There was no statistically significant correlation HPV positivity and clinicopathological features of the analysed group. In 5 (10%) of 50 samples of normal mucosal. HPV 16 presence in normal mucosa and in laryngeal squamous cell carcinoma was detected in 3 patients. Our observations suggest that HPV16 can play a role in pathogenesis of laryngeal cancer.
Morshed
Kamal
K
Klinika Otolaryngologii i Onkologii Laryngologicznej AM w Lublinie. kamal1@op.pl
Polz-Dacewicz
Małgorzata
M
Rajtar
Barbara
B
Szymański
Marcin
M
Ziaja-Sołtys
Marta
M
Gołabek
Wiesław
W
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000453:epidemiology* / Q000821:virology*; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007820:Laryngeal Mucosa / Q000737:chemistry / Q000821:virology*; D007822:Laryngeal Neoplasms / Q000737:chemistry / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009856:Oncogene Proteins, Viral / Q000032:analysis*; D050725:Papillomavirus E7 Proteins; D016133:Polymerase Chain Reaction; D015995:Prevalence
D004279:DNA, Viral; C118860:E6 protein, Human papillomavirus type 6; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; C059731:oncogene protein E7, Human papillomavirus type 16