title: [Effect of Jingjielianqiao decoction on healing of skin ulcer in rats].
abstract: OBJECTIVE
  To study the pharmacodynamics of Jingjielianqiao decoction in promoting the healing of skin ulcer in mice.
  
  
  METHODS
  Mouse models of skin ulcer were established by inducing skin trauma and scald, respectively. The skin ulcer of the mice was treated with Jingjielianqiao decoction or recombinant human epithelial growth factor (rhEGF), and the ulcer area after treatment was compared between the two groups and with their respective self control. Inflammatory cell infiltration in the ulcer was observed under the microscope.
  
  
  RESULTS
  Compared with the self-control group, the skin ulcer area of mice treated with Jingjielianqiao decoction was reduced obviously (P<0.001), and the inflammatory cell infiltration also alleviated (P<0.001). Jingjielianqiao decoction produced significantly better therapeutic effect than rhEGF.
  
  
  CONCLUSIONS
  Jingjielianqiao decoction can obviously improve the healing of skin ulcer in mice with better effect than rhEGF.
authors.affiliation: Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lxqin333@163.com
authors.forename: Xue-qing
authors.initials: XQ
authors.lastname: Liu
authors.forename: Kang
authors.initials: K
authors.lastname: Zeng
authors.forename: Hai-mei
authors.initials: HM
authors.lastname: Lan
authors.forename: Bao-tian
authors.initials: BT
authors.lastname: Chen
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D012883:Skin Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal