title: Interactions between asynchronous release and short-term plasticity in the nucleus accumbens slice.
abstract: Glutamate synapses in the nucleus accumbens (NAc) display asynchronous release in response to trains of stimulation. However, it is unclear what role this asynchronous release plays in synaptic transmission in this nucleus. This process was studied, specifically looking at the interaction between short-term depression and asynchronous release. These results indicate that synchronous and asynchronous release do not compete for a depleted readily releasable pool of vesicles.
authors.affiliation: Department of Neurology, Wheeler Center for the Neurobiology of Addiction and the Ernest Gallo Clinic and Research Ctr., 5858 Horton St., Suite 200, Emeryville, CA 94608, USA. gregh@egcrc.net
authors.forename: Gregory O
authors.initials: GO
authors.lastname: Hjelmstad
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004558:Electric Stimulation; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D009714:Nucleus Accumbens / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents; D018698:Glutamic Acid