[Effects of penehyclidine hydrochloride or atropine combined with neostigmine for antagonizing residual neuromuscular block on patient's hemodynamics].
OBJECTIVE
To investigate the effects of penehyclidine hydrochloride(PH)/atropine combined with neostigmine for antagonizing residual neuromuscular block on the hemodynamics.


METHODS
Eighty patients with elective upper abdominal surgery were randomized equally into PH group and atropine group. Five minutes after the completion of surgery, PH 0.02 mg/kg (in PH group) or atropine 0.02 mg/kg (in atropine group) in combination with neostigime 0.03 mg/kg were given intravenously to reverse the residual neuromuscular block. The heart rate (HR), mean arterial pressure (MAP) and end-tidal CO(2) pressure (P(ET)CO(2)) were recorded 5 min before anesthesia induction, 1 min before injection and 2, 5, 10, and 15 min after injection, respectively.


RESULTS
During the investigation, HR in PH group did not undergo conspicuous changes (P>0.05). HR after the injection was markedly faster than that before the injection in atropine group (P<0.01) and did not recover till 15 min after the injection (P>0.05). MAP and P(ET)CO(2) showed no evident changes and no significant difference was observed between the two groups during the investigation (P>0.05).


CONCLUSIONS
Compared with atropine, PH does not obviously affect HR and BP, but atropine may accelerate HR.
Liang
Shi-wei
SW
Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chen
Ye-ming
YM
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000768:Anesthesia, General; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D001775:Blood Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009388:Neostigmine / Q000008:administration & dosage / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors*; D011812:Quinuclidines / Q000494:pharmacology*
D009466:Neuromuscular Blocking Agents; D011812:Quinuclidines; C486140:penehyclidine; D009388:Neostigmine; D001285:Atropine