title: MagScrew TAH: an update.
abstract: The MagScrew Total Artificial Heart (TAH) system is the result of a close collaboration among the Cleveland Clinic Foundation, Foster Miller Technologies, Wilson Greatbatch Ltd, and Whalen Biomedical Inc. The system components are the thoracic blood pumping unit with attached compliance chamber and refill port, implantable electronic control unit, implantable battery pack, transcutaneous energy transmission system, external battery pack, and a telemetry system for communication with the electronic control unit. System in vitro tests are underway for system characterization and durability demonstration, whereas in vivo tests were conducted to evaluate system performance and biocompatibility under physiologic conditions. The passively filling pump uses a left master alternate left and right ejection control mode and has a Starling law-like response to venous pressure. The in vitro tests documented excellent hydraulic pump performance with high device output of over 9 l/min at left atrial pressures below 12 mm Hg. Atrial balance was well maintained under all test conditions. The in vivo tests demonstrated good biocompatibility without use of anticoagulant therapy. Experimental durations have ranged between 0 and 92 days. Postexplant evaluation of tissue samples did not reveal any sign of thromboembolic events or tissue damage due to device operation.
authors.affiliation: The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. webers2@ccf.org
authors.forename: Stephan
authors.initials: S
authors.lastname: Weber
authors.forename: Keiji
authors.initials: K
authors.lastname: Kamohara
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Klatte
authors.forename: Viviane
authors.initials: V
authors.lastname: Luangphakdy
authors.forename: Christine
authors.initials: C
authors.lastname: Flick
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Fernando
authors.initials: F
authors.lastname: Casas
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Michael
authors.initials: M
authors.lastname: Kopcak
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akiyama
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Hirschman
authors.forename: Peter A
authors.initials: PA
authors.lastname: Chapman
authors.forename: Arthur
authors.initials: A
authors.lastname: Donahue
authors.forename: William
authors.initials: W
authors.lastname: Wetterau
authors.forename: Charles
authors.initials: C
authors.lastname: Prisco
authors.forename: Roy
authors.initials: R
authors.lastname: Mast
authors.forename: Craig
authors.initials: C
authors.lastname: Sherman
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: William A
authors.initials: WA
authors.lastname: Smith
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D011211:Electric Power Supplies; D006354:Heart, Artificial; D006439:Hemodynamics; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D011474:Prosthesis Design
chemical_list: D001672:Biocompatible Materials