title: Regio-selective 10-hydroxylation of patchoulol, a sesquiterpene, by pithomyces species.
abstract: Of some 350 microorganisms screened, four strains of Pithomyces species were found to carry out regio-selective hydroxylation of patchoulol, a sesquiterpene, to 10-hydroxypatchoulol: Pithomyces sp. NRJ201, P. chartarum NRJ210, and, to a lesser extent, P. cynodontis ATCC 26150 and P. atro-olivaceus IFO 6651 were found to catalyze this reaction. A method has been developed by which 10-hydroxypatchoulol was obtained in 25 to 45% yields in 1- to 5-liter fermentation jars at 2 to 4 g of patchoulol per liter and isolated as pure material in 30% yields.
authors.affiliation: Department of Microbiology and Chemotherapy, Nippon Roche Research Center, Kajiwara, Kamakura-247, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suhara
authors.forename: S
authors.initials: S
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Yokose
authors.forename: T
authors.initials: T
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.forename: R
authors.initials: R
authors.lastname: Ninomiya
authors.forename: H B
authors.initials: HB
authors.lastname: Maruyama