Interaction of polyelectrolytes and their composites with living cells.
Since the layer-wise polyelectrolyte deposition offers the opportunity to modify surfaces for biomedical applications, interactions and toxicity between polyelectrolytes and living cells become interesting. The aim of the present work is to determine the different factors such as contact area, charge, and transplantation site that influence the cell reaction to a specific polymer. We found that toxicity is influenced by all these factors and cannot be tested easily in a model.
Chanana
Munish
M
CNR-INFM, Department of Physics, University of Genoa, 16146 Genoa, Italy.
Gliozzi
Alessandra
A
Diaspro
Alberto
A
Chodnevskaja
Irina
I
Huewel
Sabine
S
Moskalenko
Vasiliy
V
Ulrichs
Karin
K
Galla
Hans-Joachim
HJ
Krol
Silke
S
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004573:Electrolytes / Q000009:adverse effects*; D042783:Endothelial Cells / Q000187:drug effects* / Q000473:pathology*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology*; D008422:Materials Testing; D049329:Nanostructures / Q000009:adverse effects* / Q000737:chemistry*; D051381:Rats; D011917:Rats, Inbred Lew; D013552:Swine
D004573:Electrolytes