[Octafluoropropane inhalation toxicity].
Wistar rats were used to study inhalation toxicity of octafluoropropane (OFP, freon-218) at the following concentration: 300 g/m3 (4-hrs), 30 g/m3 (0.5 to 4 hrs), 3 g/m3 (8 hrs), and 0.3 g/m3 (16 hrs). According to the histological analysis, OFP at the concentrations of 300 and 30 g/m3 had a politrophic toxic effect. Target organs were the lung, trachea, bronchus, heart, kidney, and the adrenaL There were dystrophic and necrobiotic lesions in the upper airways epithelium. Subacute and chronic vesicular bronchiolitis developed on days 7 and 14, respectively. Visceral organs and brain were found plethoric and the lung was found hemorrhagic. Similar lesions were seen in the trachea, bronchus, lung, liver, spleen, kidney, adrenal, heart, and the brain. Lipid redistribution was observed in the adrenal cortex and vascular reactions of renal tissue with juxtamedullar blood shunting. Toxicity of small OFP concentrations (3 and 0.3 g/m3) was distinguished by an extended aftereffect, these concentrations did not cause visible pathomorphologic changes but gave rise to an extended pathologic process detectable by biochemistry. In all concentrations, OFP impacted erythrocyte metabolism changing the lipid composition of cell membrane and activating membrane-bound adenosinetriphos-phatases. The activities of hepatocyte and myocardiac cytoplasmatic enzymes were altered in blood plasma. Increased malonic dialdehyde in blood plasma and decreased cell antioxidant GSH in erythrocytes suggested exaggerated lipid peroxidation. These data point to the necessity of revising the existing limits for OFP concentrations in air of populated areas, working areas, and closed human environments.
Anisimov
B V
BV
Mukhamedieva
L N
LN
Ivanova
S M
SM
Markin
A A
AA
Mikos
K N
KN
Nikitin
E I
EI
D000280:Administration, Inhalation; D000337:Aerospace Medicine; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001988:Bronchiolitis / Q000139:chemically induced* / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D005466:Fluorocarbons / Q000008:administration & dosage / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D018531:Spacecraft; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D003287:Contrast Media; D005466:Fluorocarbons; C042852:perflutren