In vitro performance of the novel coronary sinus AutoRetroPerfusion Cannula.
Myocardial salvage through coronary sinus intervention has been documented. The AutoRetroPerfusion Cannula is a novel device that is able to perfuse the coronary bed retrogradely through the coronary sinus with arterial blood generated from a peripheral artery with no need for a pump. The cannula consists of a distal end that, once secured in the coronary sinus, opens an umbrella-like membrane to create pressure in the coronary sinus, and at the same time has small channels directed backwards to the right atrium to provide pressure relief. The cannula is introduced from the axillary vein under local anesthesia and the proximal end, which consists of a graft, is anastomosed to the axillary artery to start autoperfusion once the distal end is secured in the coronary sinus and the occluding membrane is open. The AutoRetroPerfusion Cannula was tested in the in vitro mock loop under 50-120 mm Hg of proximal pressure and 50, 100, and 150 ml/min of total flow in the cannula. We were able to achieve the nominal design point of 40-80 mm Hg of distal pressure and 50-150 ml/min of distal flow by adjusting the number, diameter, and length of the small backwards channels.
Navia
Jose L
JL
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Zahr
Firas
F
Fukamachi
Kiyotaka
K
Goodin
Mark
M
Ragaller
Paul
P
Chen
Ji-Feng
JF
Kopcak
Michael W
MW
Dessoffy
Raymond
R
Ootaki
Yoshio
Y
Kamohara
Keiji
K
Akiyama
Masatoshi
M
Gutierrez
Antonio
A
Navia
Jose A
JA
Atik
Fernando
F
Cosgrove
Delos M
DM
D001698:Biomedical Engineering; D006328:Cardiac Catheterization / Q000295:instrumentation; D002408:Catheters, Indwelling; D004867:Equipment Design; D006801:Humans; D066298:In Vitro Techniques; D017202:Myocardial Ischemia / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000295:instrumentation*