title: [Design and synthesis of quinoxaline derivatives and their antitumor activities].
abstract: OBJECTIVE
  To design and synthesize novel quinoxaline derivatives as antitumor agents.
  
  
  METHODS
  Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives.
  
  
  RESULTS
  The structures of the target molecules were characterized by elemental analysis, 1H NMR, MS, and IR.
  
  
  CONCLUSIONS
  At concentration of 1 x 10(-4) mol x L(-1), some of the derivatives showed equal antitumor activities to XK469.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Cui-Hua
authors.initials: CH
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.forename: Wen-Hu
authors.initials: WH
authors.lastname: Duan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011810:Quinoxalines