title: Growth-Biosynthesis Relationships in Erythromycin Fermentation.
abstract: The relationship of erythromycin biosynthesis to growth appears to vary with the fermentation medium in which the microorganism is grown. In a medium containing a complex nitrogen source, antibiotic production occurred only when growth was halted, whereas in a glycine-containing synthetic medium the two parameters increased at nearly the same time. An autostimulation of antibiotic production through addition of erythromycin is reported. Also described is the use of a labeled precursor as an index of biosynthesis rates during short periods of time.
authors.affiliation: Eli Lilly and Company, Indianapolis, Indiana.
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
authors.forename: H R
authors.initials: HR
authors.lastname: Bungay
authors.forename: R C
authors.initials: RC
authors.lastname: Pittenger