Spontaneous ophthalmic diseases in 586 New Zealand white rabbits.
The purpose of this study was to investigate spontaneous eye disease in New Zealand White (NZW) rabbits, which are commonly used for toxicity tests, and to provide reference materials for pharmaceutical companies and research centers. A total of 586 NZW rabbits were randomly chosen without sex preference and were examined using ocular equipment, including a direct ophthalmoscope, an indirect ophthalmoscope, a slit-lamp biomicroscope, a focal illuminator, and a fundus camera. This study showed that the incidence rate of temporary cataracts, regarded as a change within normal variation, was 0.5% in the NZW rabbits. Regarding abnormal ophthalmic disease, blepharitis was the most commonly observed ocular disease. Other findings included cataract, conjunctivitis, choroidal hypoplasia, keratitis, corneal scarring, eyelid laceration, posterior synechiae, uveitis, dacryocystitis, and persistent pupillary membrane. In total, the incidence rate of ophthalmic diseases was 9.6%. Based on sex and age distributions, females had more ocular diseases than males, and rabbits were less susceptible to eye diseases as they got older. In this study, photographs were taken to document findings, such as normal fundus, normal variations, ophthalmic disease, and histopathologic examination.
Jeong
Man Bok
MB
Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Kim
Na Ra
NR
Yi
Na Young
NY
Park
Shin Ae
SA
Kim
Min Su
MS
Park
Jae Hak
JH
Jeong
Seong Mok
SM
Seo
Kyoung Deok
KD
Nam
Tchi Chou
TC
Oh
Yang Seok
YS
Won
Moo Ho
MH
Seo
Kang Moon
KM
D000818:Animals; D000830:Animals, Laboratory; D001762:Blepharitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D002386:Cataract / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D003231:Conjunctivitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D003941:Diagnostic Techniques, Ophthalmological; D005123:Eye / Q000473:pathology; D005124:Eye Abnormalities / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D005128:Eye Diseases / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007634:Keratitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D008297:Male; D011817:Rabbits; D012737:Sex Factors