title: Intra-individual comparison of sentinel lymph node scintigraphy on the day of injection and on the following day in breast cancer.
abstract: OBJECTIVE
  To compare, intra-individually, the detection rates of sentinel node on lymphoscintigraphy performed on the day of injection (D0) and on the following day (D1) in breast carcinoma. We also compared 2-day and 1-day protocols in the two groups of patients.
  
  
  METHODS
  The 2-day and 1-day protocols included 76 patients in group 1 and 23 patients in group 2. Patients from group 1 underwent lymphoscintigraphy twice--at 2 h (lymphoscintigraphy 1) and 18 h (lymphoscintigraphy 2) post-injection at four sites periareolar using 99mTc sulfur colloid. Patients from group 2 underwent lymphoscintigraphy only at 2 h post-injection. The detection rates and the number of sentinel nodes were compared in the two lymphoscintigraphy examinations for group 2.
  
  
  RESULTS
  The detection rate on lymphoscintigraphy in group 1 was 92% at D0 and 96% at D1. The overall agreement between lymphoscintigraphy 1 and lymphoscintigraphy 2 was 69/76 (91%). In 2/76 women, the sentinel node disappeared at D1 on lymphoscintigraphy, but remained detectable during surgery, and in 5/76 women, the sentinel node appeared at D1 on lymphoscintigraphy. The mean number of sentinel nodes detected on lymphoscintigraphy was 2.05+/-0.14 at D0 and 1.76+/-0.11 at D1 (P=0.004) in group 2, the detection rate of the sentinel node was 20/23 (87%).
  
  
  CONCLUSIONS
  Our study demonstrated that for patients undergoing the 2-day protocol for sentinel node procedure in early stage breast cancer, the optimal imaging time would be to perform lymphoscintigraphy 1 h after injection, with the possibility of imaging patients the following day in cases where lymphoscintigraphy was negative.
authors.affiliation: Department of Nuclear Medicine, Rouen University Hospital Charles-Nicolle and Henri Becquerel Center, Rouen, France. fabrice.gutman@tnn.ap-hop-paris.fr
authors.forename: Fabrice
authors.initials: F
authors.lastname: Gutman
authors.forename: Agathe
authors.initials: A
authors.lastname: Sanson
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Piquenot
authors.forename: Anne
authors.initials: A
authors.lastname: Hitzel
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Ladonne
authors.forename: Phillipe
authors.initials: P
authors.lastname: Dessogne
authors.forename: Pierre
authors.initials: P
authors.lastname: Véra
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007267:Injections; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015588:Observer Variation; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013671:Technetium Tc 99m Sulfur Colloid / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid