Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors.
Neurogenesis occurs in the adult hippocampus and is promoted by various stimulatory factors, such as enriched environments, running exercises, learning and dietary restriction. We have previously shown that the promotion of adult neurogenesis in the hippocampus by running wheel exercise is mediated by NMDA receptors. In the present study, we report that dietary restriction enhanced the hippocampal neurogenesis in mice lacking NMDA receptor epsilon1 subunit as well as wild-type mice. This result suggests that the molecular mechanism by which dietary restriction promotes adult neurogenesis may be, in contrast to that of running exercise, independent on the NMDA receptor functions.
Kitamura
Takashi
T
Department of Biology, Graduate School of Science, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581, Japan.
Mishina
Masayoshi
M
Sugiyama
Hiroyuki
H
D000818:Animals; D001835:Body Weight / Q000502:physiology; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D004032:Diet / Q000379:methods*; D006624:Hippocampus / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D021122:Protein Subunits / Q000172:deficiency; D016194:Receptors, N-Methyl-D-Aspartate / Q000172:deficiency / Q000502:physiology*; D013997:Time Factors
C120997:NR2A NMDA receptor; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate; D001973:Bromodeoxyuridine