title: [Clinical observation on effect of huoxue jieyu decoction in treating depression after craniotomy: a report of 45 cases].
abstract: OBJECTIVE
  To observe the therapeutic effect of Huoxue Jieyu decoction (HJD) on patients with depression after craniotomy.
  
  
  METHODS
  Ninety patients were randomly divided into 2 groups according to the sequence of their consultation. The 45 patients in the treated group were treated with conventional symptomatic treatment plus oral administration of HJD, and the 38 patients in the control group were treated in the same way but with chlorimipramine (anafranil) instead of HJD. Hamilton depression (HAMD) scores before and after treatment, occurrence of adverse effects and long-term therapeutic effect of treatment were observed.
  
  
  RESULTS
  The score of HAMD was insignificantly different in 2 groups before and after treatment (P >0.05), but the occurrence of adverse effects between them was significantly different (P < 0.01).
  
  
  CONCLUSIONS
  The therapeutic effect of HJD on depression was similar to that of anafranil, but HJD has less adverse effect and more stabilized long-term effect.
authors.affiliation: Department of Brain Surgery, Qiannan Prefacture People's Hospital, Guizhou.
authors.forename: Ning-quan
authors.initials: NQ
authors.lastname: Zhou
authors.forename: Zhen-xing
authors.initials: ZX
authors.lastname: Song
authors.forename: Wei-lin
authors.initials: WL
authors.lastname: Tian
mesh_terms: D000293:Adolescent; D000328:Adult; D003399:Craniotomy / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011183:Postoperative Complications / Q000188:drug therapy
chemical_list: D004365:Drugs, Chinese Herbal