Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence.
The HtrA serine protease has been shown to be essential for bacterial virulence and for survival after exposure to many types of environmental and cellular stresses. A Listeria monocytogenes 10403S htrA mutant was found to be sensitive to oxidative and puromycin-induced stress at high temperatures, showed a reduced ability to form biofilms, and was attenuated for virulence in mice.
Wilson
Rebecca L
RL
SIGA Technologies, 4575 NW Research Way, Corvallis, OR 97330, USA.
Brown
Lindsay L
LL
Kirkwood-Watts
Dana
D
Warren
Travis K
TK
Lund
S Amanda
SA
King
David S
DS
Jones
Kevin F
KF
Hruby
Dennis E
DE
D000818:Animals; D018441:Biofilms; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics*; D006358:Hot Temperature; D008089:Listeria monocytogenes / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000472:pathogenicity; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000502:physiology*; D033903:Periplasmic Proteins / Q000235:genetics*; D011691:Puromycin / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000235:genetics*; D014774:Virulence / Q000235:genetics
D006360:Heat-Shock Proteins; D033903:Periplasmic Proteins; D011691:Puromycin; C061682:DegP protease; D012697:Serine Endopeptidases