title: The effect of adding calcium lactate to xylitol chewing gum on remineralization of enamel lesions.
abstract: The purpose of the study was to determine whether adding calcium lactate to chewing gum containing xylitol enhances remineralization of enamel surfaces using an early caries lesion model. Enamel slabs were cut from human extracted sound teeth and artificial subsurface lesions created within each. Half the enamel slabs were used as controls and stored in a humidifier while half were mounted into oral appliances worn by 10 volunteers (22-27 years old, 2 males and 8 females) in a three-leg trial, during which they wore the appliance without chewing gum, chewed gum containing xylitol + calcium lactate or chewed gum containing only xylitol 4 times a day for 2 weeks. Calcium concentrations in the enamel surfaces of control and test slabs were measured by X-ray spectrometry and degrees of remineralization were calculated. The mean degree of remineralization was greater after chewing xylitol-Ca gum (0.46 +/- 0.10) than after no gum (0.16 +/- 0.14) or after chewing xylitol gum (0.33 +/- 0.10) (p < 0.01). In conclusion, chewing gum containing xylitol + calcium lactate could enhance remineralization of enamel surface compared to chewing gum containing only xylitol or no gum chewing.
authors.affiliation: Department of Periodontology, Showa University Dental School, Tokyo, Japan. suda@senzoku.showa-u.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Suda
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: R
authors.initials: R
authors.lastname: Takiguchi
authors.forename: K
authors.initials: K
authors.lastname: Egawa
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.forename: K
authors.initials: K
authors.lastname: Hasegawa
mesh_terms: D000328:Adult; D017610:Calcium Compounds / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002638:Chewing Gum; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel; D005260:Female; D006801:Humans; D007773:Lactates / Q000627:therapeutic use*; D008297:Male; D014089:Tooth Remineralization / Q000379:methods*; D014993:Xylitol / Q000627:therapeutic use
chemical_list: D017610:Calcium Compounds; D002327:Cariostatic Agents; D002638:Chewing Gum; D007773:Lactates; C110051:calcium lactate; D014993:Xylitol