title: Rye bran diet increases epithelial cell apoptosis and decreases epithelial cell volume in TRAMP (transgenic adenocarcinoma of the mouse prostate) tumors.
abstract: A rye bran diet has been suggested to retard prostate cancer growth and increase tumor cell apoptosis in animal models and in men with prostate cancer. Transgenic mice designed to develop prostate cancer (transgenic adenocarcinoma of the mouse prostate, TRAMP) were therefore treated with a rye bran diet. TRAMP mice were fed a rye bran (n = 13) or a control diet (n = 15) from 4 to 24 wk of age. Tumor histology, cell proliferation, and apoptosis were accessed using stereological and immunohistochemical techniques. In the dorsolateral prostate lobe in TRAMP mice, epithelial cell apoptosis was increased by 31%, and the volume fraction of epithelial cells was reduced by 20% (P < 0.05) in the rye bran-treated group compared with the control diet group. There were, however, no significant changes detected in lobe weights or tumor grade. In conclusion, a rye bran diet increases epithelial apoptosis and reduces the epithelial cell fraction in TRAMP tumors.
authors.affiliation: Department of Medical Biosciences, Pathology, Umeå University, Sweden. pernilla.wikstrom@medbio.umu.se
authors.forename: Pernilla
authors.initials: P
authors.lastname: Wikstrom
authors.forename: Annika
authors.initials: A
authors.lastname: Bylund
authors.forename: Jie-Xian
authors.initials: JX
authors.lastname: Zhang
authors.forename: Goran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Par
authors.initials: P
authors.lastname: Stattin
authors.forename: Anders
authors.initials: A
authors.lastname: Bergh
mesh_terms: D000230:Adenocarcinoma / Q000178:diet therapy* / Q000473:pathology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004847:Epithelial Cells; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011471:Prostatic Neoplasms / Q000178:diet therapy* / Q000473:pathology; D011897:Random Allocation; D012434:Secale
chemical_list: D000972:Antineoplastic Agents, Phytogenic