PK and PK/PD of doxycycline in drinking water after therapeutic use in pigs.
A commercial doxycycline formulation was administered in drinking water to 12 pigs at the recommended dose of 10 mg/kg daily for 5 days. The mean plasma concentration at steady-state was 1.37 +/- 1.21 microg/mL, which was reached at 68 +/- 27.2 h postadministration. Absorption and elimination half-life values were 7.20 +/- 2.42 and 7.01 +/- 2.10 h, respectively. Most plasma concentrations during dosing were higher than the minimum inhibitory concentrations (MICs) described for the main porcine bacterial pathogens of the respiratory tract (Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica and Mycoplasma hyopneumoniae). It is concluded that when pigs were treated with doxycycline in drinking water at the recommended rate, therapeutically effective concentrations were achieved throughout the treatment period, supporting the clinical use of this tetracycline in the control of respiratory infections. However, inter-animal differences were marked.
Prats
C
C
Departament de Farmacologia i Terapèutica, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain.
El Korchi
G
G
Giralt
M
M
Cristòfol
C
C
Peña
J
J
Zorrilla
I
I
Saborit
J
J
Pérez
B
B
D016977:Actinobacillus pleuropneumoniae / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D019540:Area Under Curve; D016950:Bordetella bronchiseptica / Q000187:drug effects; D004318:Doxycycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009174:Mycoplasma / Q000187:drug effects; D016979:Pasteurella multocida / Q000187:drug effects; D013552:Swine / Q000378:metabolism*; D014881:Water Supply
D000900:Anti-Bacterial Agents; D004318:Doxycycline