title: Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.
abstract: Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.
authors.affiliation: Division of Genomic Medicine, F-Floor, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom.
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Tunbridge
authors.forename: Tania M
authors.initials: TM
authors.lastname: Stevanin
authors.forename: Margaret
authors.initials: M
authors.lastname: Lee
authors.forename: Helen M
authors.initials: HM
authors.lastname: Marriott
authors.forename: James W B
authors.initials: JW
authors.lastname: Moir
authors.forename: Robert C
authors.initials: RC
authors.lastname: Read
authors.forename: David H
authors.initials: DH
authors.lastname: Dockrell
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology*; D008585:Meningitis, Meningococcal / Q000378:metabolism / Q000473:pathology; D009345:Neisseria meningitidis / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D018272:Porins / Q000235:genetics / Q000378:metabolism; D020298:U937 Cells
chemical_list: D018272:Porins; C057699:porin protein, Neisseria; D009569:Nitric Oxide