Gross and fine motor skills of children with Hurler syndrome (MPS-IH) post umbilical cord blood transplantation: a case series report.
OBJECTIVE
Recent advancements in medical treatment of Hurler syndrome have resulted in longer life expectancies and a greater need for therapeutic services. The purpose of this case series is to provide recommendations for assessing children with Hurler syndrome after umbilical cord blood transplant (UCBT). CLINICAL DESCRIPTIONS: Two children with Hurler syndrome were seen for longitudinal assessments following an UCBT for Hurler syndrome.


METHODS
The raw scores and percentage of fine and gross motor items each child completed on the Motor Scale of the Bayley Scales of Infant Development II (BSID-II) were reviewed.


RESULTS
Both children gained new motor skills with each successive motor assessment. Both children were able to complete a higher percentage of fine motor skills than gross motor skills in the most advanced item set assessed.


CONCLUSIONS
The children presented in these two case reports both had better fine motor skills than gross motor skills, which inflated their standard scores on the BSID-II. Clinicians assessing children with Hurler syndrome should use standardized assessments that allow for differentiation of fine and gross motor skills to prevent this situation.
Dusing
Stacey C
SC
Center for Development and Learning, University of North Carolina, Chapel Hill, NC 27599, USA. sdusing@email.unc.edu
Rosenberg
Angela
A
Hiemenz
Jennifer R
JR
Piner
Shelley
S
Escolar
Maria
M
D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D009048:Motor Skills; D008059:Mucopolysaccharidosis I / Q000523:psychology / Q000628:therapy*