Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating.
A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedländer condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions.
Jia
Cheng-Sheng
CS
Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
Zhang
Ze
Z
Tu
Shu-Jiang
SJ
Wang
Guan-Wu
GW
D000447:Aldehydes / Q000737:chemistry; D001190:Arylsulfonates / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry*; D006358:Hot Temperature; D007659:Ketones / Q000737:chemistry; D008872:Microwaves; D011804:Quinolines / Q000138:chemical synthesis*; D014050:Toluene / Q000737:chemistry
D000447:Aldehydes; D001190:Arylsulfonates; D001557:Benzenesulfonates; D007659:Ketones; D011804:Quinolines; D014050:Toluene; C029501:4-toluenesulfonic acid