title: Evaluation of optimal scan duration and end time in cerebral CT perfusion study.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the optimal end time of scanning and the influence of varying the number of source images adopted for calculation of the parameter values in computerized tomography (CT) perfusion.
  
  
  METHODS
  Nineteen CT perfusion studies in 14 patients with cerebrovascular disease were retrospectively analyzed. CT perfusion scanning was performed using continuous scans of 1 sec/rotation x60 sec with 5-mm-thick sections. To determine the appropriate end time of scanning, the time-density curves (TDCs) of the anterior cerebral artery (ACA), superior sagittal sinus (SSS), and basal ganglia were analyzed. The functional maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were retrospectively generated from various numbers (30, 35, 40, 45, 50, 55, and 60) of source images. Defining the values calculated from the number of source images equal to the end time of the first pass as standard values, the percentage difference between the standard values and the values generated from various numbers of sources were evaluated.
  
  
  RESULTS
  The TDCs of SSS showed the latest end time of the first pass (mean, 38.6+/-5.2 sec; range, 32 to 48 sec). Therefore, the values calculated from the number of source images equal to the end time of the first pass of SSS were defined as standard values. Increase and decrease of the number of source images for calculation resulted in increase of the percentage difference in every parameter value. The percentage differences ranged up to 49.6% for CBF, 48.0% for CBV, and 20.0% for MTT.
  
  
  CONCLUSIONS
  Scanning until the end time of the first pass of SSS is necessary and sufficient for reliable measurement. Variable scan time based on the TDC of the SSS may be of better utility than use of fixed scan time. Further, the radiation dose could be minimized in many cases by reducing the scan time.
authors.affiliation: Department of Radiology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hirata
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Kenya
authors.initials: K
authors.lastname: Murase
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miki
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D020771:Anterior Cerebral Artery / Q000000981:diagnostic imaging; D001479:Basal Ganglia / Q000098:blood supply / Q000000981:diagnostic imaging; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media