Decreased levels of plasma adiponectin in prediabetes, Type 2 diabetes and coronary artery disease.
BACKGROUND
Adiponectin, an adipocyte-derived hormone is implicated in insulin resistance and atherosclerosis. The aim of our study is to compare the levels of adiponectin in subjects with prediabetes and diabetes with subjects with normal glucose.


METHODS
In a cross sectional study, we measured adiponectin and insulin in addition to fasting lipid panel and glucose in 28 subjects with prediabetes, 28 subjects with normal fasting glucose and 33 subjects with type 2 diabetes.


RESULTS
Adiponectin levels negatively correlate with insulin resistance index (r = -32.7). There is a significant difference in the levels of adiponectin between subjects with prediabetes and normal fasting glucose. There is a significant difference in adiponectin levels in subjects with prediabetes with Coronary artery disease (CAD) compared to those without CAD (10.24+/-1.02 vs. 7.02+/-0.92 with p<0.01). There is a significant difference in adiponectin levels in subjects with CAD compared to those without coronary artery disease (9.94+/-1.02 vs. 5.02+/-0.82 with p<0.01).


CONCLUSIONS
We conclude that decreased plasma adiponectin and insulin resistance coexist in subjects with prediabetes, diabetes and atherosclerosis. Adiponectin concentration is an independent correlate of insulin resistance and atherosclerosis.
Yaturu
Subhashini
S
Department of Endocrinology, Overton Brooks VA Medical Center, Louisiana State University Health Sciences Center, Shreveport, LA 71101-4295, U.S.A. Subhashini.Yaturu@med.va.gov
Bridges
Juanita F
JF
Subba Reddy
Dhani Reddy Rama
DR
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood*
D052242:Adiponectin; D001786:Blood Glucose