title: Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: an unusual presentation of an unusual neoplasm.
abstract: Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.
authors.affiliation: Department of Pathology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands. a.n.milne@amc.uva.nl
authors.forename: Anya N A
authors.initials: AN
authors.lastname: Milne
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Sweeney
authors.forename: Diarmuid S
authors.initials: DS
authors.lastname: O'Riordain
authors.forename: Patrick
authors.initials: P
authors.lastname: Pauwels
authors.forename: Maria
authors.initials: M
authors.lastname: Debiec-Rychter
authors.forename: G Johan A
authors.initials: GJ
authors.lastname: Offerhaus
authors.forename: Michael
authors.initials: M
authors.lastname: Jeffers
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D003937:Diagnosis, Differential; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D007080:Ileocecal Valve / Q000473:pathology* / Q000601:surgery; D017404:In Situ Hybridization, Fluorescence; D007443:Intussusception / Q000175:diagnosis* / Q000201:enzymology / Q000601:surgery; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D011993:Recombinant Fusion Proteins; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases