Lymphocyte calcium signaling from membrane to nucleus.
Ca(2+) signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca(2+) entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca(2+) entry, the function of Ca(2+) in the regulation of cell polarity and motility and the principles by which Ca(2+)-dependent transcription regulates lymphocyte function.
Gallo
Elena M
EM
Program in Immunology, Stanford University, Stanford, California 94305, USA.
Canté-Barrett
Kirsten
K
Crabtree
Gerald R
GR
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000276:immunology; D002462:Cell Membrane / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D016764:Cell Polarity / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
D015220:Calcium Channels; D002118:Calcium