title: Seventy-two hour gas exchange performance and hemodynamic properties of NOVALUNG iLA as a gas exchanger for arteriovenous carbon dioxide removal.
abstract: OBJECTIVE
  Acute respiratory failure is complicated by acidosis and altered end-organ perfusion. NOVA-LUNG iLA is an interventional lung assist (ILA) device for arteriovenous carbon dioxide removal (AVCO2R). The present study was conducted to evaluate the device for short-term CO2 removal performance and hemodynamic response.
  
  
  METHODS
  Six adult sheep received cannulation of the jugular vein and carotid artery. The ILA-AVCO2R circuit was placed on the sheep for 72 hours. Hemodynamics and PaCO2 were measured; CO2 removal was calculated while varying sweep gas flow rates (Qg), device blood flow rates (Qb), and PaCO2.
  
  
  RESULTS
  Hemodynamic variables remained normal throughout the 72 hour study. CO2 removal increased with increases in Qg or Qb. Mean CO2 removal was 119.3 ml/min for Qb 1 L/ min, Qg 5 L/min, and PaCO2 40-50 mmHg. PaCO2 was directly proportional to CO2 clearance (R=0.72, p <0.001).
  
  
  CONCLUSIONS
  NOVALUNG iLA can provide near total CO2 removal with Qb 1-2 L/min, Qg 5 L/min, and minimal flow resistance (3.88+/-0.82 mmHg/L/min). PaCO2 correlates with CO2 removal and is dependent on Qb and Qg.
authors.affiliation: Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77551-0528, USA.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Zhou
authors.forename: David B
authors.initials: DB
authors.lastname: Loran
authors.forename: Dongfang
authors.initials: D
authors.lastname: Wang
authors.forename: Brannon R
authors.initials: BR
authors.lastname: Hyde
authors.forename: Scott D
authors.initials: SD
authors.lastname: Lick
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Zwischenberger
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D002302:Cardiac Output; D002339:Carotid Arteries; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods*; D002496:Central Venous Pressure; D005260:Female; D007601:Jugular Veins; D010107:Oxygenators, Membrane; D010313:Partial Pressure; D011659:Pulmonary Gas Exchange; D011669:Pulmonary Wedge Pressure; D012756:Sheep
chemical_list: D002245:Carbon Dioxide