A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen.
Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.
Parra
Marcela
M
Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA.
Cadieux
Nathalie
N
Pickett
Thames
T
Dheenadhayalan
Veerabadran
V
Brennan
Michael J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology*; D004587:Electrophoresis, Agar Gel; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009162:Mycobacterium avium / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000382:microbiology*; D014376:Tuberculosis / Q000276:immunology* / Q000517:prevention & control / Q000662:veterinary; D032581:Tuberculosis Vaccines / Q000276:immunology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D032581:Tuberculosis Vaccines