title: Protein tyrosine phosphatase 1B inhibitors from Morus root bark.
abstract: An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1-4 inhibited PTP1B with IC(50) values ranging from 1.6+/-0.3 microM to 16.9+/-1.1 microM.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoun-dong, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: Long
authors.initials: L
authors.lastname: Cui
authors.forename: Minkyun
authors.initials: M
authors.lastname: Na
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Bae
authors.forename: Dae Gwin
authors.initials: DG
authors.lastname: Jeong
authors.forename: Seong Eon
authors.initials: SE
authors.lastname: Ryu
authors.forename: Sohee
authors.initials: S
authors.lastname: Kim
authors.forename: Bo Yeon
authors.initials: BY
authors.lastname: Kim
authors.forename: Won Keun
authors.initials: WK
authors.lastname: Oh
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D031625:Morus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases