Short-term metabolic ethanol tolerance in dogs.
Metabolic ethanol tolerance was studied in a cohort of five dogs with ethanol challenge repeated weekly over a 7-week period. During the 7-week period, the area under the blood alcohol versus time curve (AUC) increased slightly while the rate of ethanol elimination also increased slightly. During the repeated ethanol dosing, ethanol absorption shifted from approximately equal absorption in the stomach and intestine to three-fold more absorption in the intestine than in the stomach. The likely cause of the shift in absorption site was probably a concomitant change in gastric emptying that occurred with repeated dosing. This shift is significant since ethanol absorption in the small intestine has been shown to be over six-fold more rapid than ethanol absorption in the stomach.
Whitmire
David
D
MetaCodes, Inc., Watkinsville, GA 30677, USA. dave@alcoholtalks.com
Cornelius
Larry
L
Whitmire
Paula
P
D000818:Animals; D019540:Area Under Curve; D003198:Computer Simulation; D004285:Dogs; D004334:Drug Administration Schedule; D004361:Drug Tolerance / Q000502:physiology*; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D005746:Gastric Emptying / Q000187:drug effects; D005753:Gastric Mucosa / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D009010:Monte Carlo Method; D013997:Time Factors
D000431:Ethanol