Effect of Mg on the Activity of Vancomycin Against Escherichia coli.
Mg ions alleviate the inhibitory effect of vancomycin on Escherichia coli. This is not due to the formation of an antibacterial-inactive complex. It is suggested that vancomycin and Mg compete for a receptor site, or sites, on (or in) the bacterial cell.
Russell
A D
AD
Departments of Pharmaceutics and Pharmaceutical Chemistry, Welsh School of Pharmacy, Welsh College of Advanced Technology, Cardiff, Wales.
Thomas
I L
IL