Diminished neurocardiac dynamics associated with antipsychotic-induced extrapyramidal syndrome.
The relationship between antipsychotic-induced extrapyramidal syndrome (EPS) and the autonomic neurocardiac function was examined in 57 schizophrenic patients treated with atypical antipsychotics. Comprehensive assessments of EPS and heart rate dynamics were performed. There was a significant negative correlation of non-hypokinetic parkinsonism, akathisia, and dyskinesia with several linear and novel non-linear heart rate dynamics measures, suggesting reduced neurocardiac dynamics associated with some forms of EPS. Assessment of heart rate dynamics may be useful for the detection of these adverse effects and may serve as a useful non-invasive method providing a dynamic window into the alterations of complex neuronal activity.
Kim
Jong-Hoon
JH
Department of Psychiatry, Gil Medical Center, Gachon Medical School, Incheon, South Korea.
Yi
Sang Hoon
SH
Park
Kyung Tae
KT
Ahn
Yong Min
YM
Lee
Kyu Young
KY
Yang
Seung Ae
SA
Kim
Yong Sik
YS
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000494:pharmacology; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology
D014150:Antipsychotic Agents