Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia.
A functional promoter polymorphism (-116C/G) of the X-box binding protein 1 gene (XBP1) gene was reported to be associated with schizophrenia in Asian subjects. In a replication attempt, three European case-control samples comprising 2,182 German, Polish, and Swedish subjects, were genotyped for the XBP1 -116C/G polymorphism. Allele and genotype frequencies were compared between schizophrenic patients and control subjects. There were no significant case-control differences in any of the three samples, although in a meta-analysis with previous results comprising 3,612 subjects there was a borderline association between the -116G-containing genotypes and schizophrenia. We conclude that the functional XBP1 gene polymorphism is not of major importance to schizophrenia in the European populations investigated. It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder.
Jönsson
Erik G
EG
Department of Clinical Neuroscience, Psychiatry Section, R5:00, Karolinska Institutet, SE-171 76 Stockholm, Sweden. erik.jonsson@cna.ki.se
Cichon
Sven
S
Schumacher
Johannes
J
Abou Jamra
Rami
R
Schulze
Thomas G
TG
Deschner
Monica
M
Forslund
Kaj
K
Hall
Håkan
H
Propping
Peter
P
Czerski
Piotr M
PM
Dmitrak-Weglarz
Monica
M
Kapelski
Pawel
P
Driessen
Martin
M
Maier
Wolfgang
W
Hauser
Joanna
J
Rietschel
Marcella
M
Nöthen
Markus M
MM
D000483:Alleles; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D000071701:Regulatory Factor X Transcription Factors; D012559:Schizophrenia / Q000235:genetics*; D013548:Sweden; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human