The role of persistent anticardiolipin antibody as risk factor of ischemic stroke.
OBJECTIVE
To determine the role of persistent ACA and hyperviscosity as risk factor of ischemic stroke.


METHODS
A study was conducted on 76 subjects whose age 40 to 70 years. Subjects consisted of 38 patients of post ischemic stroke and 38 controls with diagnosis other than stroke. Fresh blood samples were taken and mixed with EDTA for viscosity examination and serum for ACA IgM and IgG examination. The laboratory examination for persistent ACA IgM and IgG used ELISA method, while viscosity analysis was using viscometer. Statistic analysis used chi-square and multivariate analysis with logistic regression.


RESULTS
In this study we found persistent ACA IgG in 25% of case group , and 2.63% in control group. Multivariate analysis showed persistent ACA IgG as risk factor for ischemic stroke with p < 0.05 and OR 14.11 (CI 95%:1.64;121.11). We found persistent ACA IgM in 2.78% of case group and 5.26% in control group. High blood viscosity was found in 15.79% case group and 10.53% in a control group. Statistical analysis showed no significant difference of viscosity (p = 0.740) and persistent ACA IgM (p = 1.000) between case and control group.


CONCLUSIONS
study showed that persistent ACA IgG in stroke ischemic was higher than in control subjects. Blood viscosity examination and persistent ACA IgM did not show significant difference. While persistent ACA IgG with OR 14.11 (CI: 1.64; 121.11) was the risk factor for ischemic stroke. Blood viscosity and persistent ACA IgM were not risk factors for ischemic stroke.
Immanuel
Suzanna
S
Department of Clinical Pathology, Faculty of Medicine University of Indonesia-Dr. Cipto Mangunkusumo Hospital, Jakarta.
Giantini
Astuti
A
Dharma
Rahajuningsih S
RS
Samino
D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D001809:Blood Viscosity / Q000276:immunology; D002545:Brain Ischemia / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D013997:Time Factors
D017153:Antibodies, Anticardiolipin; D015415:Biomarkers; D007070:Immunoglobulin A; D007075:Immunoglobulin M