Mycophenolic Acid Production by Penicillium brevicompactum on Solid Media.
When grown on Czapek-Dox agar, Penicillium brevicompactum produced mycophenolic acid after a vegetative mycelium had been formed and as aerial hyphae were developing. Nutrients were still plenteous in the agar when the synthesis began. If aerial hyphal development was prevented by placing a dialysis membrane over the growing fungus, no mycophenolic acid was produced. When the dialysis membrane was peeled back and, as a consequence, production of aerial hyphae began, mycophenolic acid biosynthesis was observed. We concluded that mycophenolic acid was produced only by P. brevicompactum colonies that possessed an aerial mycelium.
Bartman
C D
CD
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Doerfler
D L
DL
Bird
B A
BA
Remaley
A T
AT
Peace
J N
JN
Campbell
I M
IM