MicroRNA: the perfect host.
By creating an expression cassette that embeds the sequence of short hairpin (sh)RNA into the larger fold of a ubiquitous microRNA, scientists can achieve highly efficient target gene knockdown.
Rusk
Nicole
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D000818:Animals; D018628:Gene Dosage; D020868:Gene Silencing; D005822:Genetic Vectors; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009690:Nucleic Acid Conformation; D012319:RNA Polymerase II / Q000235:genetics; D012333:RNA, Messenger
D035683:MicroRNAs; D012333:RNA, Messenger; D012319:RNA Polymerase II