title: [Effective salvage chemotherapy with S-1 alone in a patient with lung metastasis of breast cancer].
abstract: A patient with lung metastasis of breast cancer was reported. The patient underwent surgery in December, 1999. Her breast cancer then recurred in December, 2000. After treatment failure with anthracycline and taxane antitumor drugs,she participated in a phase II study of S-1, a fluorinated pyrimidine anticancer drug, which was given orally at 80 mg/m2/day (2 doses). After completion of 4 courses of treatment,the target lesions of the lung metastasis markedly shrunk by 47.5% as compared with the pretreatment. Because salvage therapy with S-1 alone showed good antitumor efficacy and beneficial tolerability when the standard dosage was maintained, it was considered that this home therapy was effective for advanced/recurrent breast cancer that was resistant to anthracycline and taxane antitumor drugs.
authors.affiliation: Division of Oncology/Hematology, National Cancer Center Hospital East.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Itoh
authors.forename: Hironobu
authors.initials: H
authors.lastname: Minami
mesh_terms: D000284:Administration, Oral; D018943:Anthracyclines / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary; D017322:Clinical Trials, Phase II as Topic; D004334:Drug Administration Schedule; D004338:Drug Combinations; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*; D011788:Quality of Life; D016879:Salvage Therapy; D043823:Taxoids / Q000494:pharmacology; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D018943:Anthracyclines; D000964:Antimetabolites, Antineoplastic; D001952:Bridged-Ring Compounds; D004338:Drug Combinations; D011725:Pyridines; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; C080625:taxane; D010094:Oxonic Acid