Stereospecific reduction of ethyl 2' -ketopantothenate to ethyl d-(+)-pantothenate with microbial cells as a catalyst.
A novel enzymatic process for the synthesis of D-(+)-pantothenic acid through the asymmetric reduction of the 2' -ketopantothenate ester is described. Candida macedoniensis AKU 4588 was found to convert ethyl 2' -ketopantothenate (80 mg/ml) almost specifically to ethyl D-(+)-pantothenate (>98% enantiomeric excess), with a molar yield of 97.2%.
Kataoka
M
M
Department of Agricultural Chemistry, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606, Japan.
Shimizu
S
S
Doi
Y
Y
Yamada
H
H