title: Evaluation of a pumping assist lung that uses a rotating fiber bundle.
abstract: A paracorporeal respiratory assist lung (PRAL) is being developed for supplemental gas exchange to allow the native lungs of acute lung failure patients to heal. The device consists of a rotating annular microporous hollow fiber membrane bundle. The rotation augments the gas exchange efficiency of the device at constant flow-rate thereby uncoupling gas exchange and flow rate. The rotating fibers also enable the PRAL to pump the blood without the need for an additional pump or arterial cannulation. Blood flow rates will be between 500 and 750 ml/min with CO(2) removal rates of 100-130 ml/min. A prototype was manufactured with an overall surface area of 0.25 m. When rotated at 1500 rpm, CO(2) removal increased by 133% and O(2) transfer increased by 157% during an in vitro bovine blood study. The pumping of the rotating fiber bundle was assessed in a glycerol/water solution. At 1500 rpm, the PRAL generated 750 ml/min against 52 mm Hg pressure. Hemolysis of the device was assessed using in vitro bovine blood from a slaughterhouse. Plasma free hemoglobin levels were similar regardless of whether the rotating fibers were present in the PRAL, indicating that a rotating fiber bundle can be used to increase gas exchange without causing blood trauma.
authors.affiliation: McGowan Institute for Regenerative Medicine, Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15203, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Svitek
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Frankowski
authors.forename: William J
authors.initials: WJ
authors.lastname: Federspiel
mesh_terms: D000818:Animals; D001187:Artificial Organs / Q000009:adverse effects; D001698:Biomedical Engineering; D002245:Carbon Dioxide / Q000097:blood; D002417:Cattle; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung; D011474:Prosthesis Design; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000628:therapy; D012399:Rotation
chemical_list: D002245:Carbon Dioxide