Performance and reliability of the CPB/ECMO Initiative Forward Lines Casualty Management System.
The Cleveland Clinic Foundation CPB/ECMO Initiative Forward Casualty Management System is an economical, compact, transportable, disposable system designed to permit a rapid expansion of trauma management services requiring cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) pulmonary support. The system, composed of a rotary blood pump, a pump motor driver, and an electronic control console as the blood pumping subsystem, also includes commonly used compatible commercial oxygenators, venous reservoirs, and cannulae. In vitro durability testing accumulated over 100 hours without failure. In vivo reliability was tested in 10 calves under general anesthesia during 6 hours of CPB and ECMO under full heparinization at nominal operating conditions of 4-5 l/min and 2-4 l/min blood flow respectively, and mean arterial pressures between 65 and 100 mm Hg. A mean time to failure of 57 hours was reached during the animal series. Results of these test series demonstrated that this system has the capability to reliably operate during a 6-hour conventional CPB or ECMO procedure, while providing flexibility and ease of use for the operator.
Casas
Fernando
F
Lerner Research Institute, Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. casasf@ccf.org
Reeves
Andrew
A
Dudzinski
David
D
Weber
Stephan
S
Lorenz
Markus
M
Akiyama
Masatoshi
M
Kamohara
Keiji
K
Kopcak
Michael
M
Ootaki
Yoshio
Y
Zahr
Firas
F
Sinkewich
Martin
M
Foster
Robert
R
Fukamachi
Kiyotaka
K
Smith
William A
WA
D000818:Animals; D002417:Cattle; D001026:Coronary Artery Bypass / Q000191:economics / Q000295:instrumentation; D003365:Costs and Cost Analysis; D019468:Disease Management; D004209:Disposable Equipment; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000191:economics / Q000295:instrumentation; D006801:Humans; D008297:Male; D008887:Military Medicine; D015203:Reproducibility of Results; D014947:Wounds and Injuries / Q000628:therapy