Transfusions of CPDA-1 red blood cells stored for up to 28 days decrease donor exposures in very low-birth-weight premature infants.
The goal of this research was to study the safety and the efficacy of transfusing citrate-phosphate-adenine anticoagulant-preservative (CPDA-1) RBC stored for up to 28 days to reduce donor exposures in premature infants. A prospective randomized two-group study was conducted with very low-birth-weight premature infants that received at least one RBC transfusion during hospital stay. Neonates randomly assigned to Group 1 (26 infants) were transfused with CPDA-1 RBC stored for up to 28 days; those assigned to Group 2 (26 infants) received CPDA-1 RBC stored for up to 3 days. Demographic and transfusion-related data were collected. Neonates from both groups showed similar demographics and clinical characteristics. The number of transfusions per infant transfused was 4.4 +/- 4.0 in Group 1 and 4.2 +/- 3.1 in Group 2, and the number of donors per infant transfused was 1.5 +/- 0.8 (Group 1) and 4.3 +/- 3.4 (Group 2), P < 0.001. RBC transfusions containing 29.7 +/- 18.3 mmol L(-1) of potassium (RBC stored for up to 28 days) did not cause clinical or biochemical changes and reduced donor exposures by 70.2%, compared to transfusions containing 19.8 +/- 12.3 mmol L(-1) of potassium (RBC stored for up to 3 days), P < 0.001. In conclusion, RBC stored for up to 28 days safely reduced donor exposures in premature infants.
Fernandes da Cunha
D H
DH
Division of Neonatal Medicine, Department of Pediatrics, Hematology and Transfusion Medicine Service, Department of Biostatistics, Federal University of São Paulo, São Paulo, Brazil.
Nunes Dos Santos
A M
AM
Kopelman
B I
BI
Areco
K N
KN
Guinsburg
R
R
de Araújo Peres
C
C
Chiba
A K
AK
Kuwano
S T
ST
Terzian
C C N
CC
Bordin
J O
JO
D000225:Adenine; D001774:Blood Chemical Analysis; D001782:Blood Donors; D001793:Blood Preservation / Q000379:methods*; D002951:Citrates; D003257:Consumer Product Safety; D017707:Erythrocyte Transfusion / Q000379:methods* / Q000592:standards; D005947:Glucose; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D010710:Phosphates; D013997:Time Factors
C034876:CPDA solutions; D002951:Citrates; D010710:Phosphates; D005947:Glucose; D000225:Adenine