[Risk of iugr syndrome development during preeclampsia of the pregnant].
We have conducted a case-control retrospective study to determine the risk of Intra Uterine Growth Retardation (IUGR) in pregnant women with preeclampsia. We have found that IUGR is one of the most prominent features of preeclampsia and occurs in 27% of cases (Odds Ratio 1.20). IUGR occurs during fetal-placental insufficiency (ultrasound structural changes of placenta such as aging and calcifications take place in 67.8% of cases, oligohydramnia in 42.8% of cases, changes of hemodynamics in maternal -- fetal placental unit -- in 82.3% of cases; deviation from the norm of resistance index and pulse index was 1.5-2 times higher). IUGR was accompanied with the poor functional state of the fetus (85.7% according to the cardiotocographic monitoring); morphological investigation of placenta showed dystrophic and destructive changes, which finally leads to the high rate of morbidity during neonatal period (hypoxic-ischemic encephalopathy -- 66%, respiratory distress syndrome -- 36%, pneumonia and atelectasis --14%) and fetal functional immaturity confirmed by EEG.
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D000328:Adult; D018269:Carcinoma, Endometrioid / Q000453:epidemiology; D016889:Endometrial Neoplasms / Q000453:epidemiology; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D012307:Risk Factors