The pap operon of avian pathogenic Escherichia coli strain O1:K1 is located on a novel pathogenicity island.
We have identified a 56-kb pathogenicity island (PAI) in avian pathogenic Escherichia coli strain O1:K1 (APEC-O1). This PAI, termed PAI I(APEC-O1), is integrated adjacent to the 3' end of the pheV tRNA gene. It carries putative virulence genes of APEC (pap operon), other E. coli genes (tia and ireA), and a 1.5-kb region unique to APEC-O1. The kps gene cluster required for the biosynthesis of polysialic acid capsule was mapped to a location immediately downstream of this PAI.
Kariyawasam
Subhashinie
S
Iowa State University, 1802 Elwood Drive, VMRI #2, Ames, IA 50011, USA.
Johnson
Timothy J
TJ
Nolan
Lisa K
LK
D000818:Animals; D016667:Bacterial Capsules / Q000096:biosynthesis / Q000235:genetics; D002645:Chickens; D004926:Escherichia coli / Q000235:genetics* / Q000472:pathogenicity*; D010861:Fimbriae, Bacterial / Q000235:genetics*; D044404:Genomic Islands / Q000235:genetics*; D008969:Molecular Sequence Data; D012794:Sialic Acids / Q000096:biosynthesis / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics
D012794:Sialic Acids; D037521:Virulence Factors; C021319:polysialic acid