title: Microbial Transformations of Natural Antitumor Agents: Products of Rotenone and Dihydrorotenone Transformation by Cunninghamella blakesleeana.
abstract: Various species of Absidia, Aspergillus, Cunninghamella, Trichothecium, Penicillium, and Phanerochaete were found to transform rotenone to one or more metabolites. Two biotransformation products were isolated from a preparative-scale incubation of rotenone with Cunninghamella blakesleeana and identified as 1',2'-dihydro-1',2'-dihydroxyrotenone and 3'-hydroxyrotenone (amorphigenin). The catalytic reduction of the isopropylene side chain of rotenone resulted in the formation of 1',2'-dihydrorotenone. The latter was transformed by C. blakesleeana to 2'-hydroxy-1',2'-dihydrorotenone.
authors.affiliation: Division of Medicinal Chemistry and Natural Products, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242.
authors.forename: F S
authors.initials: FS
authors.lastname: Sariaslani
authors.forename: J P
authors.initials: JP
authors.lastname: Rosazza