Major impact of admission glycaemia on 30 day and one year mortality in non-diabetic patients admitted for myocardial infarction: results from the nationwide French USIC 2000 study.
OBJECTIVE
To analyse the short and long term prognostic significance of admission glycaemia in a large registry of non-diabetic patients with acute myocardial infarction.


METHODS
Assessment of short and long term prognostic significance of admission blood glucose in a consecutive population of 1604 non-diabetic patients admitted to intensive care units in France in November 2000 for a recent (<or= 48 hours) myocardial infarction.


RESULTS
In-hospital mortality, compared with that of patients with admission glycaemia below the median value of 6.88 mmol/l (3.7%), rose gradually with each of the three upper sextiles of glycaemia: 6.5%, 12.5% and 15.2%. Conversely, one year survival decreased from 92.5% to 88%, 83% and 75% (p < 0.001). Admission glycaemia remained an independent predictor of in-hospital and one year mortality after multivariate analyses accounting for potential confounders. Increased admission glycaemia also was a predictor of poor outcome in all clinical subsets studied: patients without heart failure on admission, younger and older patients, patients with or without reperfusion therapy, and patients with or without ST segment elevation.


CONCLUSIONS
In non-diabetic patients, raised admission blood glucose is a strong and independent predictor of both in-hospital and long term mortality.
Kadri
Z
Z
Hôpital Européen Georges Pompidou, Paris, France.
Danchin
N
N
Vaur
L
L
Cottin
Y
Y
Guéret
P
P
Zeller
M
M
Lablanche
J-M
JM
Blanchard
D
D
Hanania
G
G
Genès
N
N
Cambou
J-P
JP
D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005602:France / Q000453:epidemiology; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality*; D011379:Prognosis; D016019:Survival Analysis
D001786:Blood Glucose