Influence of vagal nerve stimulation on food intake and body weight--results of experimental studies.
The paper reviews recent advances in vagal nerve stimulation for the control of food intake and body weight. The vagal nerves are the predominant pathway in the "brain-gut axis" responsible for short term regulation of food intake. Stimulation of afferent vagal traffic attenuates food intake by vagal projections to nucleus tractus solitarius, arcuate nucleus and its convergence's to thalamic center of satiety. A few studies have been published in this field so far. All of them are consistent and show significant decrease in body mass during vagal stimulation. Due to promising results of experimental studies, clinical trials are expected in the near future.
Sobocki
J
J
3rd Department of General Surgery, Jagiellonian University, Medical College, Cracow, Poland. jsobocki@cm-uj.krakow.pl
Królczyk
G
G
Herman
R M
RM
Matyja
A
A
Thor
P J
PJ
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D001835:Body Weight / Q000502:physiology*; D004285:Dogs; D004435:Eating / Q000502:physiology*; D004599:Electric Stimulation Therapy; D006801:Humans; D009765:Obesity / Q000503:physiopathology / Q000628:therapy; D051381:Rats; D012528:Satiety Response / Q000502:physiology; D013552:Swine; D014630:Vagus Nerve / Q000502:physiology* / Q000503:physiopathology