Glutathione and glutathione peroxidase activities in blood of patients in early stages following kidney transplantation.
This study focuses on glutathione (GSH) level in red blood cells, as well as on glutathione peroxidases (GSH-Px) activities in red blood cells and in plasma of chronic renal failure (CRF) patients following renal transplantation. We want to focus our main attention on plasma GSH-Px, the selenoenzyme that is synthesized primarily in the kidney. In CRF patients, activity of this enzyme is significantly reduced, and the reduction decreases with the progress of the disease, reaching in the end-stage 20% to 30% of the activity of healthy patients. We have shown that following renal transplantation the activity of plasma GSH-Px is restored very rapidly, and 2 weeks after surgery it reached the value of the control group. Red blood cell GSH level is significantly higher in CRF patients, and following transplantation, no significant changes were observed. Red blood cell GSH-Px activity before transplantation was the same as in healthy patients and did not change significantly after surgery.
Zachara
Bronislaw A
BA
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland. bronzach@yahoo.com
Wlodarczyk
Zbigniew
Z
Andruszkiewicz
Jacek
J
Gromadzinska
Jolanta
J
Wasowicz
Wojciech
W
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005500:Follow-Up Studies; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood*; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011184:Postoperative Period; D011336:Probability; D012016:Reference Values; D012680:Sensitivity and Specificity
D015415:Biomarkers; D005979:Glutathione Peroxidase; D005978:Glutathione