title: Effect of radiocontrasts on selected membrane transport systems.
abstract: BACKGROUND
  This study was aimed at examining the effects of radiocontrast agents on selected membrane transport functions.
  
  
  METHODS
  The effect of diatrizoate sodium (DS), diatrizoate meglumine (DM), and diatrizoate compound (DC) on Na+/K+ pump activity and number, L-arginine, and choline transports were evaluated in erythrocytes of normal individuals and patients undergoing cardiac catheterization.
  
  
  RESULTS
  Norrmal individuals' erythrocytes potassium influxes were 1.50+/-0.35, 1.32+/-0.37, 1.28+/-0.30, and 1.01+/-0.25 mmol/L cell/h in control, DS, DM, and DC groups, respectively (P=0.004; DC vs. control). Patients exposure to Hypaque M-76 significantly diminished Na+/K+ pump activity (1.40+/-0.36 before, vs. 1.27+/-0.40 mmol/L cell/h after; P=0.039). The number of Na+/K+ pumps was reduced (156+/-36 vs. 143+/-34 pumps/erythrocyte; P=0.015) in presence of DS. L-arginine and choline transports changed only at high radiocontrast concentrations.
  
  
  CONCLUSIONS
  Selective changes in erythrocytes membrane transport function take place on exposure to radiocontrasts.
authors.affiliation: Programa de Pós-Graduação em Medicina e Ciências da Saúde (Nefrologia), Faculdade de Medicina, Hospital São Lucas e Instituto de Pesquisas Biológicas da Pontifícia, Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. marona@pucrs.br
authors.forename: Rubens Marona
authors.initials: RM
authors.lastname: de Oliveira
authors.forename: Bartira Ercília
authors.initials: BE
authors.lastname: Pinheiro da Costa
authors.forename: Fernando Custódio
authors.initials: FC
authors.lastname: Fervenza
authors.forename: Mário Bernardes
authors.initials: MB
authors.lastname: Wagner
authors.forename: Domingos Otavio
authors.initials: DO
authors.lastname: d'Avila
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Poli de Figueiredo
mesh_terms: D000704:Analysis of Variance; D001120:Arginine / Q000187:drug effects / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D006328:Cardiac Catheterization; D016022:Case-Control Studies; D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D011336:Probability; D019275:Radiopharmaceuticals / Q000009:adverse effects*; D012016:Reference Values; D012680:Sensitivity and Specificity; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000502:physiology
chemical_list: D019275:Radiopharmaceuticals; D001120:Arginine; D000254:Sodium-Potassium-Exchanging ATPase