title: Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer.
abstract: Cancer/germline (CG) antigens represent promising targets for widely applicable mono- and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC). Since little is known about their composite expression in this tumor type, we analyzed 7 CG genes (MAGE-A3, NY-ESO-1, LAGE-1, BRDT, HOM-TES-85, TPX-1 and LDHC) in 102 human NSCLC specimens. About 81% of NSCLC express at least 1 and half of the specimen at least 2 CG genes. Activation of most of these genes occurs more frequently in squamous cell cancer than in adenocarcinomas. Even though we found all genes but one to be regulated by genomic methylation, not all of them are co-expressed. In particular, combining CG genes not localized on the X-chromosome may provide effective treatment for an extended number of patients.
authors.affiliation: Department of Internal Medicine III, Johannes Gutenberg-University, Langenbeckstr. 1, 55131 Mainz, Germany, and University Hospital Ghent, Belgium.
authors.forename: Carolin
authors.initials: C
authors.lastname: Grunwald
authors.forename: Michael
authors.initials: M
authors.lastname: Koslowski
authors.forename: Tülin
authors.initials: T
authors.lastname: Arsiray
authors.forename: Karl
authors.initials: K
authors.lastname: Dhaene
authors.forename: Marleen
authors.initials: M
authors.lastname: Praet
authors.forename: Anja
authors.initials: A
authors.lastname: Victor
authors.forename: Alicia
authors.initials: A
authors.lastname: Morresi-Hauf
authors.forename: Michael
authors.initials: M
authors.lastname: Lindner
authors.forename: Bernward
authors.initials: B
authors.lastname: Passlick
authors.forename: Hans-Anton
authors.initials: HA
authors.lastname: Lehr
authors.forename: Stephan C
authors.initials: SC
authors.lastname: Schäfer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Seitz
authors.forename: Christoph
authors.initials: C
authors.lastname: Huber
authors.forename: Ugur
authors.initials: U
authors.lastname: Sahin
authors.forename: Ozlem
authors.initials: O
authors.lastname: Türeci
mesh_terms: D000951:Antigens, Neoplasm; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D005819:Genetic Markers; D018095:Germ-Line Mutation; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm; D005819:Genetic Markers