title: pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.
abstract: Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.
authors.affiliation: Department of Chemistry, The University of Sheffield, Brook Hill, Sheffield S3 7HF, United Kingdom.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Du
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Tang
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Lewis
authors.forename: Steven P
authors.initials: SP
authors.lastname: Armes
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; C030613:polymethacrylic acid; C070638:2-methacryloyloxyethyl phosphorylcholine