Drug-induced glomerulopathies.
Normal renal function depends upon an intact glomerular apparatus. Many drugs and chemicals are capable of damaging the glomerulus, causing its increased permeability to large molecules. Glomerular lesions are usually responsible for proteinuria and the nephrotic syndrome. This also holds true for the drug-induced glomerulopathies, of which membranous glomerulo-nephritis is the most frequent type of lesion encountered. Apart from this, several cases of different glomerular changes such as focal segmental glomerulosclerosis and crescentic glomerulonephritis have also been reported. The drug-induced glomerulopathies are probably immune mediated. This is, for instance, reflected in the fact that patients with drug-induced nephritic syndrome frequently have the HLA-B8 and DR3 antigens. In depth information is provided for the previously mentioned disorders.
Izzedine
Hassan
H
Pitié Salpêtrière Hospital, Department of Nephrology, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. hassan.izzedine@psl.ap-hop-paris.fr
Launay-Vacher
Vincent
V
Bourry
Edward
E
Brocheriou
Isabelle
I
Karie
Svetlana
S
Deray
Gilbert
G
D015433:Glomerulonephritis, Membranous / Q000139:chemically induced* / Q000503:physiopathology; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000502:physiology; D008181:Lupus Nephritis / Q000139:chemically induced / Q000503:physiopathology; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000503:physiopathology