Snapshot of HIV pathogenesis in China.
Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naïve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area.
Saksena
Nitin K
NK
Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead NSW 2145 Sydney, Australia. Nitin_saksena@wmi.usyd.edu.au
Wang
Bin
B
Steain
Megan
M
Yang
Rong Ge
RG
Zhang
Lin Qi
LQ
D002681:China; D004196:Disease Outbreaks; D006678:HIV / Q000235:genetics / Q000472:pathogenicity*; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D006801:Humans