title: Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.
abstract: CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.
authors.affiliation: Immunology and Infection Unit, Dept. of Biology, University of York, P.O. Box 373, York YO10 5YW, United Kingdom.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Polley
authors.forename: Simona
authors.initials: S
authors.lastname: Stager
authors.forename: Sara
authors.initials: S
authors.lastname: Prickett
authors.forename: Asher
authors.initials: A
authors.lastname: Maroof
authors.forename: Soombul
authors.initials: S
authors.lastname: Zubairi
authors.forename: Deborah F
authors.initials: DF
authors.lastname: Smith
authors.forename: Paul M
authors.initials: PM
authors.lastname: Kaye
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016219:Immunotherapy, Adoptive; D007893:Leishmania donovani / Q000235:genetics / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000628:therapy*; D051379:Mice; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000096:biosynthesis / Q000235:genetics
chemical_list: D000953:Antigens, Protozoan; D010047:Ovalbumin