Technical aspects of perfusion-weighted imaging.
There is increasing interest in using diffusion-weighted (DWI) MR imaging and perfusion-weighted MR imaging (PWI) to assist clinical decision-making in the management of acute stroke patients. Larger PWI than DWI lesions have been speculated to represent potentially salvageable tissue that is at risk of infarction unless nutritive flow is restored and presence of these mismatches have been proposed as inclusion criteria for identifying patients most likely to benefit from therapeutic intervention. Understanding the technical aspects of PWI may improve comprehension of the capabilities and limitations of this technique.
Wu
Ona
O
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA. ona@mmr.mgh.harvard.edu
Ostergaard
Leif
L
Sorensen
A Gregory
AG
D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*
D003287:Contrast Media; D019786:Gadolinium DTPA