Nickel-catalyzed cross-coupling reaction of aryl fluorides and chlorides with grignard reagents under nickel/magnesium bimetallic cooperation.
Nickel-catalyzed cross-coupling of Grignard reagents with aryl (poly)fluorides or (poly)chlorides can be achieved efficiently in the presence of a new triarylphosphine ligand bearing a nearby hydroxy group. The high reactivity and the unique chemoselectivity (ArF > ArOTf > ArSR) of the catalysis have been attributed to synergy of nickel and magnesium atoms preorganized on the ligand, as has been surmised on the basis of theoretical modeling of the reaction mechanism.
Yoshikai
Naohiko
N
Department of Chemistry, The University of Tokyo, and Nakamura Functional Carbon Cluster Project, ERATO, Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan.
Mashima
Hiroko
H
Nakamura
Eiichi
E