Comparison of family histories in FTLD subtypes and related tauopathies.
Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks.
Goldman
J S
JS
Memory and Aging Center, University of California, San Francisco, CA 94117, USA. jgoldman@memory.ucsf.edu
Farmer
J M
JM
Wood
E M
EM
Johnson
J K
JK
Boxer
A
A
Neuhaus
J
J
Lomen-Hoerth
C
C
Wilhelmsen
K C
KC
Lee
V M-Y
VM
Grossman
M
M
Miller
B L
BL
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000235:genetics; D018888:Aphasia, Primary Progressive / Q000235:genetics; D025063:Chromosome Disorders / Q000235:genetics; D015331:Cohort Studies; D003704:Dementia / Q000235:genetics*; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D012189:Retrospective Studies; D013494:Supranuclear Palsy, Progressive / Q000235:genetics; D024801:Tauopathies / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics
D016875:tau Proteins