title: Managing patients undergoing non-cardiac surgery: need to shift emphasis from risk stratification to risk modification.
abstract: Many patients undergo non-invasive testing for the detection of coronary artery disease before non-cardiac surgery. This is despite the low predictive value of positive tests in this population and the lack of any evidence of benefit of coronary revascularisation before non-cardiac surgical procedures. Further, this strategy often triggers a clinical cascade exposing the patient to progressively riskier testing and intervention and results in increased costs and unnecessary delays. On the other hand, administration of beta blockers, and more recently statins, has been shown to reduce the occurrence of perioperative ischaemic events. Therefore, there is a need for a shift in emphasis from risk stratification by non-invasive testing to risk modification by the application of interventions, which prevent perioperative ischaemia--principally, perioperative beta adrenergic blockade and perhaps treatment with statins. Clinical risk stratification tools reliably identify patients at high risk of perioperative ischaemic events and can guide in the appropriate use of perioperative medical treatment.
authors.affiliation: Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India. karthik_2010@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Karthikeyan
authors.forename: B
authors.initials: B
authors.lastname: Bhargava
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000465:Algorithms; D003324:Coronary Artery Disease / Q000175:diagnosis*; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis; D017202:Myocardial Ischemia / Q000517:prevention & control; D009204:Myocardial Revascularization / Q000379:methods; D019990:Perioperative Care / Q000379:methods*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D000319:Adrenergic beta-Antagonists