title: The relationship between variables of 123-I-metaiodobenzylguanidine cardiac imaging and clinical status of the patients with diastolic heart failure.
abstract: BACKGROUND
  The status of cardiac sympathetic nerve activity in patients with diastolic heart failure has not been fully understood. 123-I-metaiodobenzylguanidine cardiac images are valuable for evaluating cardiac sympathetic nerve activity.
  
  
  METHODS
  We obtained 123-I-metaiodobenzylguanidine cardiac images from 34 consecutive patients with moderate heart failure and an ejection fraction of > or = 45%.
  
  
  RESULTS
  The decay-corrected washout rate of 123-I-metaiodobenzylguanidine correlated with each plasma concentration of brain natriuretic peptide (standardized correlation coefficient=0.305, p<0.05), New York Heart Association functional class (standardized correlation coefficient=0.364, p<0.02), and exercise capacity (standardized correlation coefficient=-0.388, p<0.04). A multiple regression analysis revealed that the washout rate independently predicted plasma concentration of brain natriuretic peptide (standardized regression coefficient=0.367, p<0.02). In a univariate regression, the washout rate did not significantly correlate with the presence of ischemic heart disease (p=0.254); in a multivariate regression, the presence of ischemic heart disease did not predict the washout rate. For the 14 patients with sinus rhythm, there was a marginal negative correlation between the E/A velocity ratio of the transmitral flow and washout rate (standardized correlation coefficient=-0.518, p<0.07).
  
  
  CONCLUSIONS
  In diastolic heart failure, cardiac sympathetic nerve activity increases proportionally to severity of the disease.
authors.affiliation: Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Sugiura
authors.forename: Koji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Takeda
authors.forename: Takemasa
authors.initials: T
authors.lastname: Dohmori
authors.forename: Masaki
authors.initials: M
authors.lastname: Ogata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kondo
authors.forename: Shogo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fukutomi
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D003971:Diastole; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D005500:Follow-Up Studies; D015637:Gated Blood-Pool Imaging / Q000379:methods*; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D011379:Prognosis; D019275:Radiopharmaceuticals; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine