Cytotoxic constituents from the whole plant of Corydalis pallida.
Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 microg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.
Kim
Hyang Rim
HR
College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Min
Hye-Young
HY
Jeong
Yeon Hee
YH
Lee
Sang Kook
SK
Lee
Nam Sook
NS
Seo
Eun-Kyoung
EK
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D031311:Corydalis / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy
D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D001599:Berberine