Effect of diet and tylosin on chronic diarrhea in beagles.
Seven beagles in a colony of dogs had chronic diarrhea for at least 30 days. The dogs were subsequently treated with tylosin 20 mg/kg BW q24h PO for 10 days. During the treatment period, the feces became firmer but remained loose. When the treatment was discontinued, the diarrhea reappeared in 3 weeks. The feces remained abnormally loose in all dogs treated with metronidazole, trimethoprim-sulfadiazine, or doxycycline and prednisone. The diet was then changed for 10 days from a highly digestible moist pet food to a dry food developed for normal adult dogs. The feces again became firmer, although still loose in some dogs. The period was then extended to 3 month, but the fecal consistency continued to fluctuate from ideal to diarrhea. The dogs were treated a 2nd time with tylosin 20 mg/kg BW q24h PO for 10 days. The feces then became significantly firmer and remained so throughout a 3-month follow-up. We conclude that the combination of diet and tylosin was more effective than either agent alone in control of chronic diarrhea.
Westermarck
Elias
E
Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Hämeentie 57, 00014 University of Helsinki, Finland. elias.westermarck@helsinki.fi
Frias
Rafael
R
Skrzypczak
Teresa
T
D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease / Q000628:therapy; D003967:Diarrhea / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy* / Q000662:veterinary*; D004032:Diet / Q000662:veterinary*; D004283:Dog Diseases / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy*; D004285:Dogs; D004359:Drug Therapy, Combination; D005243:Feces / Q000737:chemistry; D015645:Tylosin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D015645:Tylosin