Predictors of outcome in LAAM, buprenorphine, and methadone treatment for opioid dependence.
This study examined (1) predictors of treatment outcome for opioid-dependent participants in a single-site controlled trial comparing methadone, buprenorphine, and LAAM treatments and (2) the extent to which various subpopulations of patients may have more successful outcomes with each medication. The relationships between patient demographics, drug use history, and psychological status and outcome measures of treatment retention, opiate use, and cocaine use were assessed. We believe this study to be the first to demonstrate that predictors of treatment success appear to be largely similar in LAAM, buprenorphine, and methadone treatment for opioid dependence. We did not find any factors that would strongly guide selection of one medication over others.
Marsch
Lisa A
LA
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. marsch@ndri.org
Stephens
Mary Ann Chutuape
MA
Mudric
Timothy
T
Strain
Eric C
EC
Bigelow
George E
GE
Johnson
Rolley E
RE
D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use*; D002047:Buprenorphine / Q000494:pharmacology / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000494:pharmacology / Q000627:therapeutic use; D008692:Methadyl Acetate / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D011446:Prospective Studies; D017450:Receptors, Opioid, mu / Q000819:agonists; D012044:Regression Analysis; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D017450:Receptors, Opioid, mu; D002047:Buprenorphine; D008692:Methadyl Acetate; D008691:Methadone