Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample.
Intelligence, as measured by standardized psychological tests, has been shown to be highly heritable, though identifying specific genes influencing general intelligence has proven difficult. We conducted genome-wide linkage analyses to identify chromosomal regions containing genes influencing intelligence, as measured by WAIS full-scale IQ (FSIQ), performance IQ (PIQ) and verbal IQ (VIQ). Non-parametric multipoint linkage analyses were conducted with Merlin-regress software, using a sample of 1,111 genotyped and phenotyped individuals from 201 families, ascertained as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The strongest evidence of linkage was obtained for FSIQ on chromosome 6 (LOD=3.28, 12 cM) near the marker D6S1006. This region was also implicated with suggestive linkage in a recently published genome screen of IQ in Australian and Dutch twin pairs, and it has been implicated in linkage studies of developmental dyslexia. Our findings provide further support that chromosome 6p contains gene(s) affecting intelligence.
Dick
Danielle M
DM
Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA. dickd@psychiatry.wustl.edu
Aliev
Fazil
F
Bierut
Laura
L
Goate
Alison
A
Rice
John
J
Hinrichs
Anthony
A
Bertelsen
Sarah
S
Wang
Jen C
JC
Dunn
Gerald
G
Kuperman
Sam
S
Schuckit
Marc
M
Nurnberger
John
J
Porjesz
Bernice
B
Beglieter
Henri
H
Kramer
John
J
Hesselbrock
Victor
V
D000437:Alcoholism / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002886:Chromosomes, Human, Pair 17; D002896:Chromosomes, Human, Pair 6; D005190:Family; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D007361:Intelligence Tests; D008126:Lod Score
D005819:Genetic Markers