[Severe bleeding in a patient with anti-c alloantibodies and a rare Rhesus phenotype treated with compatible erythrocyte concentrate from the blood bank of the Council of Europe].
An 84-year-old women had repeated gastrointestinal bleeding from a Dieulafoy lesion, i.e. a gastric or duodenal ulcer containing an aberrant artery. Her blood group was AB-D negative; her Rhesus phenotype was CCdee. In addition, antibody screening revealed anti-c alloantibodies as the result of a previous transfusion. Donors negative for D and c are very rare in Caucasian populations. Compatible red cell concentrates are available only from the European Bank of Frozen Blood of the Council of Europe, located at Sanquin in Amsterdam, Tthe Netherlands. The patient could be saved by requesting compatible erythrocyte concentrate from this blood bank. Severe blood loss poses a serious challenge in patients who are positive for alloantibodies against blood group antigens with a high frequency in the population, and in patients who are themselves negative for such antigens. The presence of alloantibodies is often the result of previous blood transfusions. In view of the large number of antigens on erythrocytes, one should therefore be conservative as to blood transfusion in order to prevent alloantibody formation.
Sonke
G S
GS
Afd. Interne Geneeskunde, Ziekenhuis Gooi-Noord, Blaricum.
Overbeeke
M A M
MA
de Graaff
W E
WE
Elisen
M G
MG
D000369:Aged, 80 and over; D001771:Blood Banks; D001787:Blood Group Incompatibility / Q000209:etiology; D001788:Blood Grouping and Crossmatching; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000628:therapy; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis*; D010641:Phenotype; D012204:Rh-Hr Blood-Group System; D013997:Time Factors
D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System