title: Unmasking of Brugada syndrome by an antiarrhythmic drug in a patient with septic shock.
abstract: Asymptomatic Brugada syndrome patients often display concealed Brugada-type electrocardiogram patterns that result in under-diagnosis of this syndrome. These patients include individuals of both genders and a wide range of ages. They are as likely as non-Brugada patients to have normal longevity or to suffer from a critical illness. Here we report a case of septic shock in which Brugada-type electrocardiogram patterns were induced by pilsicainide administration for the treatment of atrial fibrillation. This case report suggests that some drugs used in the treatment of septic shock can unmask the Brugada-type electrocardiogram pattern and induce lethal ventricular tachyarrhythmia.
authors.affiliation: Division of Intensive Care and Coronary Care Unit, Nippon Medical School, Tokyo, Japan. terajima.katsuyuki@nifty.com
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Terajima
authors.forename: Takesi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Onodera
authors.forename: Shinhiro
authors.initials: S
authors.lastname: Takeda
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Sakamoto
mesh_terms: D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000187:drug effects; D006801:Humans; D008297:Male; D012772:Shock, Septic / Q000188:drug therapy* / Q000503:physiopathology; D013577:Syndrome; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents