[Effect of oxymatrine on serum matrix metalloproteinase-2 and its inhibitor in patients with chronic hepatitis B and liver cirrhosis].
OBJECTIVE
To observe the effect of oxymatrine on the level of serum matrix metalloproteinase-2 (MMP-2) and its inhibitor (TIMP-2) in patients with chronic hepatitis B (CHB) and post-hepatitis B liver cirrhosis (LC), as well as on liver fibrosis indexes as hyaluronic acid (HA), laminin (LN) and IV type collagen (IV C).


METHODS
Changes of all the above-mentioned indexes in patients with CHB (n = 36) and LC (n = 36) before and after treatment were determined, and the relationship of MMP-2 and TIMP-2 with liver fibrosis indexes were analyzed.


RESULTS
Oxymatrine could decrease the levels of MMP-2, HA, LN and IV C in patients with severe or moderate CHB and LC of Child-pugh A, B and C grade, as compared with the data before treatment (P < 0.05). Serum level of MMP-2 and TIMP-2 was well correlated with the levels of liver cirrhosis indexes.


CONCLUSIONS
MMP-2 and TIMP-2 can be used as a reference for evaluating the degree of LC, and oxymatrine has a certain anti-LC effect.
Liu
Jiang
J
Central Hospital of Huzhou City, Zhejiang 313000. liujiangxm@yahoo.com.cn
Shi
Bai-nian
BN
He
Jian-fang
JF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000470:Alkaloids / Q000627:therapeutic use*; D024141:Collagen Type IV / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D008875:Middle Aged; D011807:Quinolizines / Q000627:therapeutic use*; D029909:Sophora; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000097:blood*; D000093842:Matrines
D000470:Alkaloids; D024141:Collagen Type IV; D006820:Hyaluronic Acid; D007797:Laminin; D020778:Matrix Metalloproteinase 2; D011807:Quinolizines; D019716:Tissue Inhibitor of Metalloproteinase-2; C037573:oxymatrine; D000093842:Matrines