The temperature sensitivity of the cholinergic responses of cortical neurons in the guinea pig brain.
Studies on slices of the parietal cortex of the guinea-pig brain showed that a change in temperature from 20 degrees C to 36 degrees C led to increases in responses to microintophoretic application of acetylcholine to individual nerve cells. The greatest changes occurred over two temperature ranges: 27-29 degrees C and 34-36 degrees C. Increases in the cholinergic response were accompanied by increases in the spontaneous activity of the neurons.
Mednikova
Yu S
YS
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerov Street, 117485 Moscow, Russia.
Pasikova
N V
NV
D000109:Acetylcholine / Q000008:administration & dosage*; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D006168:Guinea Pigs; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology*; D013696:Temperature
D000109:Acetylcholine