title: High incidence of Hb D-Los Angeles [beta121(GH4)Glu-->Gln] in Denizli Province, Aegean region of Turkey.
abstract: Denizli Province is located in the inner part of the Aegean region of Turkey and is one of the target areas for premarital screening. Here we report the abnormal hemoglobins (Hbs) observed during a premarital screening program in our region. According to our results, Hb D-Los Angeles [beta1211(GH4)Glu-->Gln (GAA-->CAA] (also known as D-Punjab, D-North Carolina, D-Portugal, Oak Ridge and D-Chicago), is the most frequent abnormal Hb in this region.
authors.affiliation: Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey. eatalay@pamukkale.edu.tr
authors.forename: Erol O
authors.initials: EO
authors.lastname: Atalay
authors.forename: Hasan
authors.initials: H
authors.lastname: Koyuncu
authors.forename: Berna
authors.initials: B
authors.lastname: Turgut
authors.forename: Ayfer
authors.initials: A
authors.lastname: Atalay
authors.forename: Sanem
authors.initials: S
authors.lastname: Yildiz
authors.forename: Anzel
authors.initials: A
authors.lastname: Bahadir
authors.forename: Aylin
authors.initials: A
authors.lastname: Köseler
mesh_terms: D005787:Gene Frequency; D005820:Genetic Testing; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D015994:Incidence; D017720:Molecular Epidemiology; D011291:Premarital Examinations; D014421:Turkey / Q000453:epidemiology
chemical_list: D006455:Hemoglobins, Abnormal; C032001:hemoglobin D; C026237:hemoglobin D Punjab