A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.
Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium--a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer--was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers--the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway--and to associate these variations with cancer risk.
Hunter
D J
DJ
Riboli
E
E
Haiman
C A
CA
Albanes
D
D
Altshuler
D
D
Chanock
S J
SJ
Haynes
R B
RB
Henderson
B E
BE
Kaaks
R
R
Stram
D O
DO
Thomas
G
G
Thun
M J
MJ
Blanché
H
H
Buring
J E
JE
Burtt
N P
NP
Calle
E E
EE
Cann
H
H
Canzian
F
F
Chen
Y C
YC
Colditz
G A
GA
Cox
D G
DG
Dunning
A M
AM
Feigelson
H S
HS
Freedman
M L
ML
Gaziano
J M
JM
Giovannucci
E
E
Hankinson
S E
SE
Hirschhorn
J N
JN
Hoover
R N
RN
Key
T
T
Kolonel
L N
LN
Kraft
P
P
Le Marchand
L
L
Liu
S
S
Ma
J
J
Melnick
S
S
Pharaoh
P
P
Pike
M C
MC
Rodriguez
C
C
Setiawan
V W
VW
Stampfer
M J
MJ
Trapido
E
E
Travis
R
R
Virtamo
J
J
Wacholder
S
S
Willett
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WC
D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D052138:Genes, Neoplasm; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D019683:Penetrance; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism
D012739:Gonadal Steroid Hormones