[Comparing studies on the differences of CCl4 liver injury and immunity liver injury mice models].
Comparison between CCl4 liver injury model and immunity liver injury model was studied through physiological, biochemical and gene expression profile methods, and the pathological mechanism of them were discussed. There are significant changes about the physiological, biochemical parameters including ALT,AST between two model groups and normal control group. Among the 14112 target genes, 379 and 293 differentially expressed genes were screened out from the both two model groups respectively in gene expression profile experiments, including 105 common, differentially expressed genes. The results indicate that the two models of CCl4 and immunity have some similarities. However, the differences between them are also obvious. It is useful for the further investigation on the liver-injury mechanism and pathological process of the two different liver-injury models.
Chen
Yong
Y
Hubei Provincial Key Laboratory of Biotechnology of Traditional Chinese Medicine, Hubei University, Wuhan.
Cheng
Ming
M
Han
Feng Mei
FM
Du
Peng
P
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology*; D020411:Oligonucleotide Array Sequence Analysis
D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione