Dectin-1: a signalling non-TLR pattern-recognition receptor.
Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines. These activities could influence the resultant immune response and can, in certain circumstances, lead to autoimmunity and disease. As I discuss here, understanding the molecular mechanisms behind these functions has revealed new concepts, including collaborative signalling with the Toll-like receptors (TLRs) and the use of spleen tyrosine kinase (SYK), that have implications for the role of other non-TLR pattern-recognition receptors in immunity.
Brown
Gordon D
GD
Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa. gordon.brown@mweb.co.za
D000818:Animals; D006801:Humans; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000145:classification* / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000145:classification* / Q000502:physiology*; D051192:Receptors, Pattern Recognition / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D051193:Toll-Like Receptors / Q000502:physiology; D000099181:Dectin-1
D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; D000099181:Dectin-1