title: Summary of contributions to GAW Group 12: multivariate methods.
abstract: Here we summarize the contributions to Group 12 of Genetic Analysis Workshop (GAW) 14, held in Noordwijkerhout, The Netherlands. The theme of this group, multivariate methods, covered a broad range of statistical applications. Most of the contributors considered Problem 1 of the GAW. However, one paper considered the bivariate analysis of two binary phenotypes generated by the simulated data in Problem 2. Some contributors focused on statistical issues involved in considering multiple variables, and others on extensions to the variance-components methodology for analysis of quantitative traits. Applications to the Collaborative Study on the Genetics of Alcoholism data identified a single-nucleotide polymorphism (SNP) on chromosome 4 associated with the ttth1-ttth4 phenotypes, and replicated previous findings of linkage on chromosome 4 for alcohol consumption, using microsatellite and SNP data.
authors.affiliation: Division of Biostatistics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota 55905, USA. mandrade@mayo.edu
authors.forename: Mariza
authors.initials: M
authors.lastname: de Andrade
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Mendell
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods; D020732:Cytogenetic Analysis / Q000379:methods*; D004843:Epistasis, Genetic; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008126:Lod Score; D015999:Multivariate Analysis; D010641:Phenotype; D019655:Quantitative Trait, Heritable
chemical_list: D005819:Genetic Markers