[60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity.
In the present work, we report the effects of C(60)-pretreatments on acute carbon tetrachloride intoxication in rats, a classical model for studying free-radical-mediated liver injury. Our results show that aqueous C(60) suspensions prepared without using any polar organic solvent not only have no acute or subacute toxicity in rodents but they also protect their livers in a dose-dependent manner against free-radical damage. To be sure, according to histopathological examinations and biological tests, pristine C(60) can be considered as a powerful liver-protective agent.
Gharbi
Najla
N
UMR CNRS 8612, Faculté de Pharmacie, Université Paris XI, Rue J-B Clément, F92296 Châtenay-Malabry, France.
Pressac
Monique
M
Hadchouel
Michelle
M
Szwarc
Henri
H
Wilson
Stephen R
SR
Moussa
Fathi
F
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D002251:Carbon Tetrachloride; D004305:Dose-Response Relationship, Drug; D037741:Fullerenes / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control*; D008657:Metabolic Clearance Rate; D049329:Nanostructures / Q000009:adverse effects; D051381:Rats; D014018:Tissue Distribution; D016896:Treatment Outcome
D000975:Antioxidants; D037741:Fullerenes; D002251:Carbon Tetrachloride; C069837:fullerene C60