title: [Regressive changes after short-term neoadjuvant antihormonal therapy in prostatic carcinoma: the value of Gleason grading].
abstract: Although neoadjuvant, antihormonal therapy does not lead to an improvement in the outcome of prostatic carcinoma it is still used in the short-term in a subset of patients. Here we report the regressive changes due to this short-term treatment and analyse the impact on Gleason grading. The most frequent regressive changes in 82 tumors treated short-term were determined and quantified. The results were compared to a matched control group and also to the preoperative needle biopsies.A steep increase in regressive changes was observed within the first 4 weeks. After this point, changes increased only mildly. Within the first 2 weeks of treatment no significant changes compared to control tissue were present. Compared to the preoperative needle biopsies, pretreated tumors showed a significant upgrading. After 2 weeks of neoadjuvant antihormonal therapy, regressive changes are so great, that Gleason grading can no longer be recommended.
authors.affiliation: Pathologisches Institut, Universitätsklinikum Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim. rainer.grobholz@path.ma.uni-heidelberg.de
authors.forename: R
authors.initials: R
authors.lastname: Grobholz
authors.forename: A
authors.initials: A
authors.lastname: Riester
authors.forename: C G
authors.initials: CG
authors.lastname: Sauer
authors.forename: M
authors.initials: M
authors.lastname: Siegsmund
mesh_terms: D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D006727:Hormone Antagonists / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D006727:Hormone Antagonists