How is the mouse germ-cell lineage established?
Six cells have been detected in the early mouse embryo that express the transcriptional repressor Blimp1--as also do all the 40 or so cells that constitute the founder germ cell pool a day later. Are these half-dozen cells the ancestors of the entire mouse germ cell lineage?
McLaren
Anne
A
The Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK. a.mclaren@gurdan.cam.ac.uk
Lawson
Kirstie A
KA
D000818:Animals; D019070:Cell Lineage; D005775:Gastrula / Q000166:cytology; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
C513258:Prdm1 protein, mouse; D012097:Repressor Proteins; D014157:Transcription Factors; D000074462:Positive Regulatory Domain I-Binding Factor 1