title: Redox biology of blood revisited: the role of red blood cells in maintaining circulatory reductive capacity.
abstract: There is an increasing recognition of the role of red blood cells (RBCs) in cell signaling above and beyond its oxygen (O(2))-carrying function. A recent forum published in the December 2004 issue of Antioxidants & Redox Signaling focused on redox biology of blood and the intricate signaling pathways of RBCs or its free components, i.e., hemoglobin, with the vasculature. The forum provided an up-to-date source of information on this emerging and exciting area of blood biology and the underlying redox chemistry. In the current short review, we have revisited the topic of redox biology of blood and focused on yet another emerging area of research, which deals with the reductive power of blood and the physiological Redox Signal.
authors.affiliation: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Buehler
authors.forename: Abdu I
authors.initials: AI
authors.lastname: Alayash
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001775:Blood Circulation / Q000502:physiology*; D002465:Cell Movement; D049109:Cell Proliferation; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010084:Oxidation-Reduction
chemical_list: D001205:Ascorbic Acid