title: Bcl-2 immunoreactivity in human cutaneous Meissner and Pacinian corpuscles.
abstract: The occurrence and distribution of Bcl-2, a protein involved in the death-life cell pathways, was investigated in the peripheral sensory nervous system of healthy adult humans, including lumbar dorsal root ganglia, nerve trunks and glabrous skin (to analyze sensory corpuscles) using Western blot and immunohistochemistry. The antibody used labelled a protein of 26 kDa of estimated molecular weight corresponding with Bcl-2. Immunohistochemistry showed that only a neuronal population in dorsal root ganglia, some axons in peripheral nerves and the axon supplying Meissner and Pacinian corpuscles contained Bcl-2, whereas peripheral glial cells (i.e. satellite glial cells, Schwann cell, and lamellar cells of sensory corpuscles) did not. These results suggest that in normal conditions, Bcl-2 is only present in some neuronal, but not glial, elements of the sensory peripheral nervous system. The functional significance, if any, of these results remains to be determined.
authors.affiliation: Departamento de Morfología y Biología Celular, Universidad de Oviedo, 33006 Oviedo, Spain.
authors.forename: T
authors.initials: T
authors.lastname: González-Martínez
authors.forename: D F
authors.initials: DF
authors.lastname: Monjil
authors.forename: A
authors.initials: A
authors.lastname: Aguado-Barrios
authors.forename: J
authors.initials: J
authors.lastname: Cobo
authors.forename: G
authors.initials: G
authors.lastname: Germanà
authors.forename: J A
authors.initials: JA
authors.lastname: Vega
mesh_terms: D000328:Adult; D015153:Blotting, Western / Q000379:methods; D005727:Ganglia, Spinal / Q000166:cytology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008465:Mechanoreceptors / Q000378:metabolism*; D008875:Middle Aged; D010141:Pacinian Corpuscles / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism; D012867:Skin / Q000166:cytology; D043222:Ubiquitin Thiolesterase / Q000378:metabolism
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D009418:S100 Proteins; C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase