title: Genomics in C. elegans: so many genes, such a little worm.
abstract: The Caenorhabditis elegans genome sequence is now complete, fully contiguous telomere to telomere and totaling 100,291,840 bp. The sequence has catalyzed the collection of systematic data sets and analyses, including a curated set of 19,735 protein-coding genes--with >90% directly supported by experimental evidence--and >1300 noncoding RNA genes. High-throughput efforts are under way to complete the gene sets, along with studies to characterize gene expression, function, and regulation on a genome-wide scale. The success of the worm project has had a profound effect on genome sequencing and on genomics more broadly. We now have a solid platform on which to build toward the lofty goal of a true molecular understanding of worm biology with all its implications including those for human health.
authors.affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
authors.forename: Ladeana W
authors.initials: LW
authors.lastname: Hillier
authors.forename: Alan
authors.initials: A
authors.lastname: Coulson
authors.forename: John I
authors.initials: JI
authors.lastname: Murray
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Bao
authors.forename: John E
authors.initials: JE
authors.lastname: Sulston
authors.forename: Robert H
authors.initials: RH
authors.lastname: Waterston
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D018509:DNA, Helminth / Q000737:chemistry / Q000235:genetics; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D049751:Genome, Helminth; D023281:Genomics / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000379:methods / Q000639:trends; D017422:Sequence Analysis, DNA
chemical_list: D018509:DNA, Helminth