title: [Perioperative pain therapy for knee endoprosthetics].
abstract: Total knee arthroplasty (TKA) is associated with significant postoperative pain. Adequate analgesics and techniques are required for early mobilization, continuous passive motion and intensified physical therapy as well as for high-quality postoperative analgesia.However, in the immediate postoperative setting the excessive nociceptive input can be blocked by using doses which are most frequently associated with adverse effects like dizziness, nausea and vomiting, sedation and risk of respiratory depression. The use of peripheral nerve blocks is recommended after orthopaedic surgery. After TKA, the continuous "3 in 1 nerve block" has been proven to be more effective than conventional patient controlled intravenous opioid therapy as well as than epidural analgesia accompanied by side effects. Postoperative analgesic techniques influence surgical outcome, duration of hospitalization and re-convalescence. The use of regional analgesia after TKA may initially lead to higher costs but it is counterbalanced by a reduction in morbidity and mortality, decrease in hospitalization, improved re-convalescence and a better functional outcome.
authors.affiliation: Klinik für Anaesthesiologie, Klinikum rechts der Isar, Technische Universität, München. K.Wagner@lrz.tum.de
authors.forename: K J
authors.initials: KJ
authors.lastname: Wagner
authors.forename: E F
authors.initials: EF
authors.lastname: Kochs
authors.forename: V
authors.initials: V
authors.lastname: Krautheim
authors.forename: L
authors.initials: L
authors.lastname: Gerdesmeyer
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D018771:Arthralgia / Q000188:drug therapy* / Q000517:prevention & control*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D009407:Nerve Block / Q000379:methods*; D010149:Postoperative Pain / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D019990:Perioperative Care / Q000379:methods*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011475:Prosthesis Failure
chemical_list: D000700:Analgesics