title: New Selective Growth Inhibitors of Sphaerotilus natans, Anslimins A and B.
abstract: Selective growth inhibitors of Sphaerotilus natans were detected in the culture broths of several strains of Streptomyces. Anslimins A and B were isolated from the culture broth of Streptomyces oganonensis by adsorption on resinous adsorbent followed by elution with 50% aqueous acetone. The A and B components were then separated by cellulose powder chromatography. Physicochemical parameters of anslimins A and B revealed that these compounds are new peptide-containing structures. Anslimins A and B inhibited growth of S. natans at 0.78 and 0.39 mug/ml, respectively, but showed no activity against any of the other test microorganisms at 100 to 200 mg/ml. The anslimins had no harmful effect on guppies at a concentration of 100 mg/liter.
authors.affiliation: Fermentation Research Laboratories, Sankyo Company, Ltd., Shibakubo, Tanashi, Tokyo 188, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: M
authors.initials: M
authors.lastname: Terao