A sigma28-regulated nonflagella gene contributes to virulence of Campylobacter jejuni 81-176.
A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure.
Goon
Scarlett
S
Enteric Diseases Dept., Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Ewing
Cheryl P
CP
Lorenzo
Maria
M
Pattarini
Dawn
D
Majam
Gary
G
Guerry
Patricia
P
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002169:Campylobacter Infections / Q000378:metabolism*; D016123:Campylobacter jejuni / Q000235:genetics* / Q000472:pathogenicity / Q000648:ultrastructure; D004195:Disease Models, Animal; D005289:Ferrets / Q000382:microbiology; D009154:Mutation; D012808:Sigma Factor / Q000502:physiology*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; C064971:FliA protein, Bacteria; D012808:Sigma Factor; D037521:Virulence Factors