title: Increasing compliance with long-term therapy: avoiding complications and adverse events.
abstract: Compliance with long-term therapy is an important consideration in any chronic disease. Patients with gastroesophageal reflux disease (GERD) frequently stop and start treatment based on their symptoms. This form of therapy ("on-demand treatment") has been shown to be effective in patients with non-erosive reflux disease and may reduce the costs associated with long-term therapy. However, continuous medical therapy for erosive esophagitis is associated with fewer relapses and better outcomes. Similarly, long-term therapy administered continuously reduces complications such as stricture and may decrease the development of dysplasia in Barrett's esophagus.
authors.affiliation: University of Wisconsin Medical School, Madison, Wisconsin, USA.
authors.forename: Nimish
authors.initials: N
authors.lastname: Vakil
mesh_terms: D001471:Barrett Esophagus / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000473:pathology; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D006801:Humans; D010349:Patient Compliance; D054328:Proton Pump Inhibitors
chemical_list: D005765:Gastrointestinal Agents; D054328:Proton Pump Inhibitors