title: Progresses in the medical treatment of advanced colorectal cancer.
abstract: In the last 2 decades, major progresses have been made in the management of patients with advanced colorectal cancer (ACC). The modulation of 5-fluorouracil (5-FU) by folinic acid (LV), followed by the introduction of irinotecan and oxaliplatin have significantly improved the outcome of these patients. New strategies consist of oral fluoropyrimidines, and of targeted agents to inhibit cancer signalisation.
authors.affiliation: Department of Medical Oncology, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France.
authors.forename: V
authors.initials: V
authors.lastname: Sultan-Amar
authors.forename: E
authors.initials: E
authors.lastname: Fabre-Guillevin
authors.forename: P
authors.initials: P
authors.lastname: Piedbois
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents