title: Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell.
abstract: Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.
authors.affiliation: Department of Family Medicine, College of Medicine, Konyang University, Daejon 320-718, Korea.
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Kang
authors.forename: Yoon Young
authors.initials: YY
authors.lastname: Lee
authors.forename: Byung Yeon
authors.initials: BY
authors.lastname: Yu
authors.forename: Beom-Seok
authors.initials: BS
authors.lastname: Yang
authors.forename: Kyung-Hwan
authors.initials: KH
authors.lastname: Cho
authors.forename: Do Kyoung
authors.initials: DK
authors.lastname: Yoon
authors.forename: Yong Kyun
authors.initials: YK
authors.lastname: Roh
mesh_terms: D052242:Adiponectin / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000473:pathology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D010957:Plasmids / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D052242:Adiponectin; D011994:Recombinant Proteins; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue