Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition.
Cachoux
Fréderic
F
ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Hönggerberg, HCI H 405, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
Isarno
Thomas
T
Wartmann
Markus
M
Altmann
Karl-Heinz
KH
D001562:Benzimidazoles / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; D034261:Epothilones; C093787:epothilone A; C031000:benzimidazole