title: Disseminated giant cell arteritis with inflammatory arthritis and C-ANCA.
abstract: Giant cell arteritis (GCA) is well known for its involvement of the proximal aorta and its branches, classically causing headache, visual impairment, and elevations in the erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP). We describe a case of biopsy-proven GCA initially presenting with limb claudication, oligoarticular inflammatory arthritis, and a positive antineutrophil cytoplasmic antibody with cytoplasmic staining (C-ANCA), treated successfully with a combination of prednisone and weekly methotrexate. This case illustrates the wide spectrum of features that can be seen with GCA, including the occasional presence of C-ANCA. The C-ANCA became negative after treatment.
authors.affiliation: Department of Medicine, Section of Rheumatology and Immunology, 982055 University of Nebraska Medical Center, Omaha, NE 68198, USA. msnow@unmc.edu
authors.forename: Marcus H
authors.initials: MH
authors.lastname: Snow
authors.forename: Stanley
authors.initials: S
authors.lastname: Radio
authors.forename: Ted R
authors.initials: TR
authors.lastname: Mikuls
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism*; D001168:Arthritis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic