Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatum.
Neurotrophic signaling is thought to be important for neuroplasticity in certain forebrain regions following psychostimulant exposure. In this study, we found that repeated administration of amphetamine (5 mg/kg, once daily, 5 days) to rats significantly increased tyrosine kinase-B receptor mRNA levels in the striatum, ventral bed nucleus, and piriform cortex. The most robust increase in tyrosine kinase-B expression occurred in dorsal aspects of the striatum, which also showed elevated levels after a single amphetamine injection. These findings indicate that changes in striatal tyrosine kinase-B signaling could play a role in neuroadaptations and behavioral changes induced by amphetamine treatment.
Meredith
Gloria E
GE
Department of Cellular and Molecular Pharmacology, Chicago Medical School/Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA. Gloria.Meredith@rosalindfranklin.edu
Steiner
Heinz
H
D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation / Q000187:drug effects*; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000235:genetics / Q000378:metabolism*; D053634:TYK2 Kinase
D000697:Central Nervous System Stimulants; D012333:RNA, Messenger; D000661:Amphetamine; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; D053634:TYK2 Kinase; C499357:Tyk2 protein, rat