title: Approach to novel functional foods for stress control 2. Microarray assessment of exercise in healthy volunteers.
abstract: DNA microarray was used to measure stress response by exercise in peripheral blood leukocytes. Aerobic exercise did not alter mRNA pattern or urinary secretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Strenuous exercise increased urinary secretion of 8-OHdG and altered mRNA pattern in microarray. These results suggest that moderate exercise, i. e. aerobic exercise, did not show any change in 8-OHdG, an oxidative stress marker, or mRNA expression in the leukocytes, which might reflect whole body neurohormanal changes. In addition, strenuous exercise produced quite different expression pattern from those of psychological stress.
authors.affiliation: Department of Nutrition, The University of Tokushima Graduate School, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakaya
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hata
authors.forename: Kaori
authors.initials: K
authors.lastname: Ishida
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Morita
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Rokutan
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers / Q000652:urine; D004247:DNA / Q000032:analysis; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D015444:Exercise; D005502:Food; D006304:Health Status; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D010807:Physical Endurance; D005082:Physical Exertion; D012333:RNA, Messenger / Q000378:metabolism; D013315:Stress, Psychological / Q000517:prevention & control*; D013997:Time Factors; D014838:Volunteers
chemical_list: D015415:Biomarkers; D012333:RNA, Messenger; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine