title: [Evaluation of the protective effect of magnesium on amikacin ototoxicity by electrophysiologic tests in guinea pigs].
abstract: OBJECTIVE
  This experimental study was performed to evaluate the protective effect of magnesium on amikacin ototoxicity.
  
  
  METHODS
  Twenty-seven guinea pigs (54 ears) with normal auropalpebral reflexes and otomicroscopic examination, auditory brain stem responses (ABR), and transient evoked otoacoustic emissions (TEOAE) were randomly divided into four groups to receive amikacin once 15 mg/kg daily (group 1 and 3) and twice 7.5 mg/kg daily (group 2 and 4) for seven days. Groups 3 and 4 were administered oral MgCl an hour after amikacin use at a dose of 39 mmol/l and 19.5 mmol/l, respectively, for seven days. Otomicroscopic examination, ABR and TEOAE measurements were repeated on the third, fifth, and seventh days.
  
  
  RESULTS
  Compared to group 1, decreases in TEOAE amplitudes and reproducibility and increases in ABR thresholds were significant in group 2 (p<0.05). However, in groups 3 and 4, TEOAE amplitudes remained unchanged, or even increased and the reproducibility of TEOAE responses and ABR thresholds showed no significant changes (p>0.05).
  
  
  CONCLUSIONS
  Our data show that oral magnesium may play a protective role on amikacin ototoxicity.
authors.affiliation: Department of Otolaryngology, Medicine Faculty of Trakya University, Edirne, Turkey. erbulut2004@yahoo.com.
authors.forename: Erdoğan
authors.initials: E
authors.lastname: Bulut
authors.forename: Recep
authors.initials: R
authors.lastname: Yağiz
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taş
authors.forename: Cem
authors.initials: C
authors.lastname: Uzun
authors.forename: Cetin
authors.initials: C
authors.lastname: Yildirim
authors.forename: Kadir
authors.initials: K
authors.lastname: Kaymak
authors.forename: Ahmet R
authors.initials: AR
authors.lastname: Karasalioğlu
mesh_terms: D000284:Administration, Oral; D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001309:Auditory Threshold / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced* / Q000517:prevention & control; D015636:Magnesium Chloride / Q000008:administration & dosage*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D020011:Protective Agents / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D020011:Protective Agents; D015636:Magnesium Chloride; D000583:Amikacin