New Selective Growth Inhibitors of Sphaerotilus natans, Anslimins A and B.
Selective growth inhibitors of Sphaerotilus natans were detected in the culture broths of several strains of Streptomyces. Anslimins A and B were isolated from the culture broth of Streptomyces oganonensis by adsorption on resinous adsorbent followed by elution with 50% aqueous acetone. The A and B components were then separated by cellulose powder chromatography. Physicochemical parameters of anslimins A and B revealed that these compounds are new peptide-containing structures. Anslimins A and B inhibited growth of S. natans at 0.78 and 0.39 mug/ml, respectively, but showed no activity against any of the other test microorganisms at 100 to 200 mg/ml. The anslimins had no harmful effect on guppies at a concentration of 100 mg/liter.
Takiguchi
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Y
Fermentation Research Laboratories, Sankyo Company, Ltd., Shibakubo, Tanashi, Tokyo 188, Japan.
Yoshikawa
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H
Terao
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M