title: Synthesis of 8-aminoadenosine 5'-(aminoalkyl phosphates), analogues of aminoacyl adenylates.
abstract: A short and efficient route for the synthesis of aminoalkyl 8-aminoadenylates, potential aminoacyl-tRNA synthetase inhibitors, is presented. Aminoalkyl 8-aminoadenylates were synthesized using a 5'-H-phosphonate strategy involving minimal protecting group manipulations and a single final deprotection step.
authors.affiliation: Division of Organic and Bioorganic Chemistry, MBB, Scheele Laboratory, Karolinska Institutet, S-17177 Stockholm, Sweden.
authors.forename: Esmail
authors.initials: E
authors.lastname: Yousefi-Salakdeh
authors.forename: Merita
authors.initials: M
authors.lastname: Murtola
authors.forename: Anders
authors.initials: A
authors.lastname: Zetterberg
authors.forename: Esther
authors.initials: E
authors.lastname: Yeheskiely
authors.forename: Roger
authors.initials: R
authors.lastname: Strömberg
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000031:analogs & derivatives*; D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy
chemical_list: D004791:Enzyme Inhibitors; D000249:Adenosine Monophosphate; D000604:Amino Acyl-tRNA Synthetases; D000241:Adenosine