title: [Importance of IgG anti-CagA antibodies of Helicobacter pylori in Venezuelan patients with gastric diseases].
abstract: Helicobacter pylori is one of the most common bacterial infections worldwide. It is associated with chronic gastritis, peptic ulcer disease and constitutes a major risk factor for gastric adenocarcinoma and lymphoma. The aim of this study was to evaluate the specific serologic immunoglobulin G (IgG) response to whole cells proteins, CagA and urease antigens of Helicobacter pylori in a Venezuelan population. We evaluated 66 patients from the Hospital Universitario de Caracas, attending in the gastroscopy service. H. pylori infection was detected by culture and rapid urease test. IgG antibodies against, CagA and ureases were tested by enzyme-linked immunosorbent assay method using highly purified recombinant antigens. We demonstrated the presence of H. pylori in 48/66 (72.7%), by culture and rapid urease test. We found a seroprevalence of 45 (68%) to whole cells, 34/66 (51%) to CagA and 18/66 (27%) to urease. The positive rates of CagA antibodies in patients with gastric ulcer, gastric cancer and chronic gastritis were 87.8%, 77.7% y 40.8% respectively. The serum antibodies anti-CagA were similar between peptic ulcer disease and gastric cancer patients.
authors.affiliation: Instituto de Investigaciones Odontológicas, Facultad de Odontología, Universidad Central de Venezuela, Caracas, Venezuela. mperrone@cantv.net
authors.forename: Marianella
authors.initials: M
authors.lastname: Perrone
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Muñoz
authors.forename: Margarita
authors.initials: M
authors.lastname: Camorlinga
authors.forename: María
authors.initials: M
authors.lastname: Correnti
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Cavazza
authors.forename: Vicente
authors.initials: V
authors.lastname: Lecuna
authors.forename: Javier
authors.initials: J
authors.lastname: Torres
mesh_terms: D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013272:Stomach Diseases / Q000276:immunology* / Q000382:microbiology*; D014510:Urease / Q000276:immunology; D014687:Venezuela
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C080866:cagA protein, Helicobacter pylori; D014510:Urease