Secondary metabolites from Ganoderma lucidum and Spongiporus leucomallellus.
The hydrodistillates and solvent extracts of the fruit bodies of Ganoderma lucidum (Fr.) P. Karst. and Spongiporus leucomallellus (Murril) A. David were investigated. The constituents in both oils comprised hydrocarbons, monoterpenes, sesquiterpenes, and fatty acids. Major volatiles of G. lucidum were trans-anethol, R-(-)-linalool, S-(+)-carvone and alpha-bisabolol, while the essential oil of S. leucomallellus contained relatively large amounts of R-(-)-1-octene-3-ol, R-(-)-linalool, 1-hepten-3-one and (Z)-nerolidol. From the n-hexane extract of G. lucidum, the steroid ester ergosta-7,22-diene-3beta-yl pentadecanoate could be identified. From S. leucomallellus two constituents showing structures of 3,4-seco-lanostane type triterpene acids were identified as (+)-23-oxo-3,4-seco-lanosta-4(28),7(8),9(11),24(31)-tetraene-3,26-dicarboxylic acid and (+)-20-hydroxy-23-oxo-3,4-seco-lanosta-4(28),7(8),9(11),24(31)-tetraene3,26-dicarboxylic acid, respectively. Cytotoxicity and antimicrobial activity of selected compounds were investigated using standard tests.
Campos Ziegenbein
Fernando
F
Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz-6, D-20146 Hamburg, Germany. FerCampos@aol.com
Hanssen
Hans-Peter
HP
König
Wilfried A
WA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002784:Cholesterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D011124:Polyporaceae / Q000737:chemistry* / Q000378:metabolism*; D012015:Reference Standards; D020940:Reishi / Q000737:chemistry* / Q000378:metabolism*; D012632:Secosteroids / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
C509453:23-oxo-3,4-seco-lanosta-4(28),7(8),9(11),24(31)-tetraene-3,26-dicarboxylic acid; C509454:5,8-dioxy-24-methylcholesta-6,9(11),22-triene-3-ol; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012632:Secosteroids; D002784:Cholesterol