Contribution of sialic acid-binding adhesin to pathogenesis of experimental endocarditis caused by Streptococcus gordonii DL1.
An insertional mutation in hsa, the gene encoding the sialic acid-binding adhesin of Streptococcus gordonii DL1, resulted in a significant reduction of the infection rate of the organism and an inflammatory reaction in the rat aortic valve with experimental endocarditis, suggesting that the adhesin contributes to the infectivity of the organism for heart valves.
Takahashi
Yukihiro
Y
Department of Microbiology, Nippon Dental University School of Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan. biseibut@tky.ndu.ac.jp
Takashima
Eizo
E
Shimazu
Kisaki
K
Yagishita
Hisao
H
Aoba
Takaaki
T
Konishi
Kiyoshi
K
D018829:Adhesins, Bacterial / Q000502:physiology*; D000818:Animals; D001021:Aortic Valve / Q000382:microbiology / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000378:metabolism*; D006349:Heart Valve Diseases / Q000382:microbiology / Q000473:pathology; D051381:Rats; D013290:Streptococcal Infections / Q000378:metabolism*; D013291:Streptococcus / Q000472:pathogenicity*
D018829:Adhesins, Bacterial