title: Bacterial nitration of 4-chlorobiphenyl.
abstract: In the course of a study dealing with the biodegradation of 4-chlorobiphenyl by strain B-206, we noticed that the gram-negative bacterium accumulated different metabolic intermediates depending on the nitrogen source of the medium. Hence, in the presence of nitrate, strain B-206 produced four compounds which were identified as 2- and 4-hydroxy-4'-chlorobiphenyl and 2- and 4-hydroxy-mononitro-4'-chlorobiphenyl. The accumulation of these compounds in the culture medium indicated the presence of a monooxygenase in strain B-206 leading to the production of arene oxide intermediates. The possible transformation of 4-chlorobiphenyl to an arene oxide by this bacterial strain is a matter of concern because of the high reactivity of these arene oxides with biological material.
authors.affiliation: Centre de Recherche en Bactériologie, Institut Armand-Frappier, Université du Québec, Laval, Québec H7N 4Z3, and Institut National de la Recherche Scientifique, INRS (Santé), Université du Québec, Montréal, Québec H1N 3M5, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Sylvestre
authors.forename: R
authors.initials: R
authors.lastname: Massé
authors.forename: F
authors.initials: F
authors.lastname: Messier
authors.forename: J
authors.initials: J
authors.lastname: Fauteux
authors.forename: J G
authors.initials: JG
authors.lastname: Bisaillon
authors.forename: R
authors.initials: R
authors.lastname: Beaudet