title: Vasculitis and infection: effects of immunosuppressive therapy.
abstract: The immunosuppressive therapy in systemic vasculitis leads to immunological dysfunctions. The consequences of granulocytopenia and cellular immune deficits are infections of different etiologies in up to 50% of vasculitis patients. The leading severe infections are sepsis and pneumonia induced by a broad spectrum of pathogens (extra- and intra-cellular growing bacteria, fungi, parasites and viruses). The contribution of infections to the mortality of vasculitis patients is important and should induce early and careful control of these events.
authors.affiliation: Department of Chest and Infectious Diseases, Helios Klinikum Emil von Behring affil Charité Universitätsmedizin, Berlin, Germany. haloheck@zedat.fu-berlin.de
authors.forename: H M
authors.initials: HM
authors.lastname: Lode
authors.forename: M
authors.initials: M
authors.lastname: Schmidt-Ioanas
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D003141:Communicable Diseases / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects* / Q000379:methods*; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D011014:Pneumonia / Q000276:immunology*; D018805:Sepsis / Q000276:immunology*; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents