title: Autogenous bone graft in conjunction with enamel matrix derivative in the treatment of deep periodontal intra-osseous defects: a report of 13 consecutively treated patients.
abstract: OBJECTIVE
  The purpose of the present study was to investigate the effectiveness of a regenerative procedure based on supra-crestal soft tissue preservation in association with combined autogenous bone (AB) graft/enamel matrix derivative (EMD) application in the treatment of deep periodontal intra-osseous defects.
  
  
  METHODS
  Thirteen consecutively treated patients, seven females and six males, aged 30-65 years, three smokers, were included. A total of 15 deep, one- to two-wall intra-osseous defects were selected. Immediately before surgery and 6 months after surgery, pocket probing depth (PPD), clinical attachment level (CAL), and gingival recession (REC) were recorded.
  
  
  RESULTS
  PPD amounted to 9.4+/-1.8 mm before surgery, and decreased to 4.7+/-1.2 mm post-surgery (p<0.0000). CAL varied from 10.5+/-2.0 mm pre-surgery to 6.2+/-1.7 mm post-surgery (p<0.0000), with CAL gain averaging 4.3+/-1.4 mm. Fourteen (93.3%) defects presented CAL gain >/=3 mm. REC change was 0.4+/-0.7 mm.
  
  
  CONCLUSIONS
  Results from the present study indicated that a regenerative procedure based on supra-crestal soft tissue preservation and combined AB/EMD treatment leads to a clinically and statistically significant improvement of soft tissue conditions of deep periodontal intra-osseous defects.
authors.affiliation: Research Centre for the Study of Periodontal Diseases, University of Ferrara, Ferrara, Italy. l.trombelli@unife.it
authors.forename: Leonardo
authors.initials: L
authors.lastname: Trombelli
authors.forename: Marco
authors.initials: M
authors.lastname: Annunziata
authors.forename: Salvatore
authors.initials: S
authors.lastname: Belardo
authors.forename: Roberto
authors.initials: R
authors.lastname: Farina
authors.forename: Alessandro
authors.initials: A
authors.lastname: Scabbia
authors.forename: Luigi
authors.initials: L
authors.lastname: Guida
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005889:Gingival Recession / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins