title: Clinically significant gastro-oesophageal reflux following oesophageal flap repair for oesophageal atresia and tracheo-oesophageal fistula.
abstract: Clinically significant gastro-oesophageal reflux (GOR) following oesophageal atresia and tracheo-oesophageal fistula (OA/TOF) repair is commonly considered normal sequela after repair. A retrospective review of patients operated on by two consultants was undertaken. All patients underwent oesophageal tailoring and augmentation for reconstruction of their oesophagus. The presence of clinically significant GOR was confirmed by contrast swallows, 24 hour pH study and endoscopy. Clinically significant GOR occurred in 7 (13%) of the 54 patients operated for OA and TOF. Two patients responded to non-surgical management. Four children (one with extensive tracheo-bronchomalacia and one with CHARGE association) had anti-reflux surgery (three Nissen and one Thal). We believe that oesophageal tailoring and augmentation for reconstruction of the oesophagus has the advantage of creating a more uniform oesophagus thus avoiding swallowing difficulty, bolus obstruction and the need of oesophageal dilatations too often accepted as integral to the problem following OA repair.
authors.affiliation: Central Manchester and Manchester Children's University Hospitals, Manchester, UK. antonio.morabito@cmmc.nhs.uk
authors.forename: A
authors.initials: A
authors.lastname: Morabito
authors.forename: N T
authors.initials: NT
authors.lastname: Plummer
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
mesh_terms: D004933:Esophageal Atresia / Q000601:surgery*; D004947:Esophagus / Q000601:surgery*; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D013524:Surgical Flaps / Q000009:adverse effects*; D013908:Thoracotomy; D013997:Time Factors; D014138:Tracheoesophageal Fistula / Q000151:congenital / Q000601:surgery*