title: The quest for brain disorder biomarkers.
abstract: The identification of disease markers in tissues and body fluids requires an extensive and thorough analysis of its protein constituents. In our efforts to identify biomarkers for affective and neurological disorders we are pursuing several different strategies. On one hand we are using animal models that represent defined phenotypes characteristic for the respective disorder in humans. In addition, we are analyzing human specimens from carefully phenotyped patient groups. Several fractions representing different protein classes from human cerebrospinal fluid obtained by lumbar puncture are used for this purpose. Our biomarker identification efforts range from classical proteomics approaches such as two dimensional gel electrophoresis and mass spectrometry to phage display screens with cerebrospinal fluid antibodies.
authors.affiliation: Max Planck Institute of Psychiatry, Molecular, Cellular, Clinical Proteomics, Munich, Germany.
authors.forename: Christoph W
authors.initials: CW
authors.lastname: Turck
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Maccarrone
authors.forename: Eser
authors.initials: E
authors.lastname: Sayan-Ayata
authors.forename: Archana M
authors.initials: AM
authors.lastname: Jacob
authors.forename: Claudia
authors.initials: C
authors.lastname: Ditzen
authors.forename: Helena
authors.initials: H
authors.lastname: Kronsbein
authors.forename: Isabel
authors.initials: I
authors.lastname: Birg
authors.forename: Can-Carlo
authors.initials: CC
authors.lastname: Doertbudak
authors.forename: Katrin
authors.initials: K
authors.lastname: Haegler
authors.forename: Maria
authors.initials: M
authors.lastname: Lebar
authors.forename: Larysa
authors.initials: L
authors.lastname: Teplytska
authors.forename: Nik
authors.initials: N
authors.lastname: Kolb
authors.forename: Nkemdilim
authors.initials: N
authors.lastname: Uwaje
authors.forename: Richard
authors.initials: R
authors.lastname: Zollinger
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D015415:Biomarkers; D001927:Brain Diseases / Q000378:metabolism*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis / Q000276:immunology; D004195:Disease Models, Animal; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D013058:Mass Spectrometry; D010449:Peptide Mapping; D020543:Proteome / Q000032:analysis*; D040901:Proteomics
chemical_list: D000906:Antibodies; D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D020543:Proteome