Amplification of chirality in hydrogen-bonded tetrarosette helices.
The amplification of chirality in hydrogen-bonded tetrarosette assemblies under thermodynamic equilibrium is described. The extent of the chiral amplification obtained by means of "sergeants-and-soldiers" experiments depends only on the structure of the assembly and it is independent of the methodology used for the formation of the tetrarosette assemblies. The difference in free energy (deltaG(o)(M/P)) between the M- and P-diastereomeric helices is up to 40 times higher than for double rosette assemblies.
Mateos-Timoneda
Miguel A
MA
Laboratory of Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology and Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Crego-Calama
Mercedes
M
Reinhoudt
David N
DN