[The M/SAR elements of the bithorax complex in Drosophila melanogaster].
The bithorax (BX) complex of Drosophila is a complex polygenic region with a multifactorial system of regulation. One of the levels of the regulatory system of the BX complex is its association with the nuclear skeleton structures through a specific interaction of the M/SAR DNA with the nuclear matrix proteins. In the present work, M/SAR elements were mapped on the molecular-genetic map of the region. All of the elements examined were found to colocalize with regulatory elements and form clusters that restrict/bracket the genetically active domains. All M/SAR DNA revealed was shown to bins specifically to the purified Drosophila melanogaster lamin.
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D000818:Animals; D002874:Chromosome Mapping; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster; D017344:Genes, Insect / Q000502:physiology*; D006570:Heterochromatin / Q000378:metabolism*; D034882:Lamins / Q000378:metabolism*; D045170:Matrix Attachment Regions / Q000502:physiology*; D005810:Multigene Family / Q000502:physiology*; D012045:Regulatory Sequences, Nucleic Acid / Q000502:physiology
D029721:Drosophila Proteins; D006570:Heterochromatin; D034882:Lamins