Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide.
The antioxidant activity of two polysaccharides isolated from the Indian medicinal plants, Ocimum sanctum and Tinospora malabarica, was studied. Only the O. sanctum polysaccharide (OSP) showed significant activity. OSP could prevent oxidative damage to liposomal lipids and plasmid DNA induced by various oxidants such as iron, AAPH and gamma-radiation, besides scavenging important ROS such as the superoxide radical and hydrogen peroxide and inhibiting xanthine oxidase. In addition, OSP could prevent gamma-radiation-mediated cell deaths in mouse splenocytes.
Subramanian
Mahesh
M
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India. schatt@apsara.barc.ernet.in
Chintalwar
Gajanan J
GJ
Chattopadhyay
Subrata
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D051379:Mice; D031339:Ocimum / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism; D010946:Plants, Medicinal; D010957:Plasmids / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D017382:Reactive Oxygen Species; D013154:Spleen / Q000166:cytology; D013481:Superoxides / Q000378:metabolism; D031610:Tinospora / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D000975:Antioxidants; D016877:Oxidants; D010936:Plant Extracts; D011134:Polysaccharides; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; D013481:Superoxides; D014969:Xanthine Oxidase