The prevalence of metabolic syndrome in patients with gout: a multicenter study.
It has been suggested that hyperuricemia and possibly gout are associated with the metabolic syndrome, but there have been no direct studies. This study was undertaken to obtain the prevalence of the metabolic syndrome in patients with gout and to compare it with those from the general population studies. This was a 4-institutional case-historical control study composed of 168 patients with gout. We assessed the prevalence of metabolic syndrome according to the ATP III criteria and compared the prevalence with that of the historical controls. To elucidate the factors in gout that were associated with metabolic syndrome, a multivariate analysis was done. The age-adjusted prevalence of metabolic syndrome in gout patients was 43.6%, which was significantly higher than that of the Korean control population (5.2%) from the previous studies. Patients with gout had more components of metabolic syndrome than did the controls. Body mass index (BMI, OR = 1.357 (95%CI 1.111-1.657)) and high density lipoprotein (HDL, OR = 0.774 (95%CI 0.705-0.850)) were the variables most significantly associated with the occurrence of metabolic syndrome in gout, but alcohol consumption did not show such associations. Gout is associated with the metabolic syndrome, and furthermore, obesity and dyslipidemia were the factors most associated with the syndrome in these patients.
Rho
Young Hee
YH
Division of Rheumatology, Korea University Anam Hospital, Seoul, Korea.
Choi
Seong Jae
SJ
Lee
Young Ho
YH
Ji
Jong Dae
JD
Choi
Kyung Mook
KM
Baik
Sei Hyun
SH
Chung
Seung-hie
SH
Kim
Chae-Gi
CG
Choe
Jung-Yoon
JY
Lee
Sung Won
SW
Chung
Won Tae
WT
Song
Gwan Gyu
GG
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D006073:Gout / Q000150:complications*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
D008075:Lipoproteins, HDL