Probiotics. Some evidence of their effectiveness.
OBJECTIVE
To define the term probiotics, to indicate how to identify products that have been proven beneficial, and to assess the quality of evidence regarding probiotics.


METHODS
A few level I studies support the effectiveness of specific probiotics for certain diagnoses. For most so-called probiotics, however, weak or no evidence supports their effectiveness.


RESULTS
Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Level I evidence supports use of VSL#3 for maintaining remission of inflammatory colitis. Probiotics for treating vaginal infections, Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14, have level I evidence of effectiveness, but are not available in Canada. Specific probiotics taken for certain indications improve health and have few side effects.


CONCLUSIONS
Limited but good evidence supports the role of certain probiotics in medical practice. Because consumer pressure will undoubtedly stimulate further interest in probiotics, family doctors need to be informed about them so they can advise their patients appropriately.
Reid
Gregor
G
Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ont. gregor@uwo.ca
Hammond
Jo-Anne
JA
D002170:Canada; D003967:Diarrhea / Q000188:drug therapy; D004348:Drug Labeling; D052776:Female Urogenital Diseases / Q000188:drug therapy; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D043183:Irritable Bowel Syndrome / Q000188:drug therapy; D052801:Male Urogenital Diseases; D019936:Probiotics / Q000494:pharmacology / Q000627:therapeutic use*; D012449:Safety