title: Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients.
abstract: First-degree relatives of type 2 diabetic patients (offspring) are often characterized by insulin resistance and reduced physical fitness (VO2 max). We determined the response of healthy first-degree relatives to a standardized 10-wk exercise program compared with an age-, sex-, and body mass index-matched control group. Improvements in VO2 max (14.1 +/- 11.3 and 16.1 +/- 14.2%; both P < 0.001) and insulin sensitivity (0.6 +/- 1.4 and 1.0 +/- 2.1 mg x kg(-1) x min(-1); both P < 0.05) were comparable in offspring and control subjects. However, VO2 max and insulin sensitivity in offspring were not related at baseline as in the controls (r = 0.009, P = 0.96 vs. r = 0.67, P = 0.002). Likewise, in offspring, exercise-induced changes in VO2 max did not correlate with changes in insulin sensitivity as opposed to controls (r = 0.06, P = 0.76 vs. r = 0.57, P = 0.01). Skeletal muscle oxidative capacity tended to be lower in offspring at baseline but improved equally in both offspring and controls in response to exercise training (delta citrate synthase enzyme activity 26 vs. 20%, and delta cyclooxygenase enzyme activity 25 vs. 23%. Skeletal muscle fiber morphology and capillary density were comparable between groups at baseline and did not change significantly with exercise training. In conclusion, this study shows that first-degree relatives of type 2 diabetic patients respond normally to endurance exercise in terms of changes in VO2 max and insulin sensitivity. However, the lack of a correlation between the VO2 max and insulin sensitivity in the first-degree relatives of type 2 diabetic patients indicates that skeletal muscle adaptations are dissociated from the improvement in VO2 max. This could indicate that, in first-degree relatives, improvement of insulin sensitivity is dissociated from muscle mitochondrial functions.
authors.affiliation: Dept. of Endocrinology & Diabetes M, Aarhus Univ. Hospital, Aarhus Sygehus, Nørrebrogade 42-44, DK-8000 Aarhus C, Denmark. oest@dadlnet.dk
authors.forename: Torben
authors.initials: T
authors.lastname: Østergård
authors.forename: Jesper L
authors.initials: JL
authors.lastname: Andersen
authors.forename: Birgit
authors.initials: B
authors.lastname: Nyholm
authors.forename: Sten
authors.initials: S
authors.lastname: Lund
authors.forename: K Sreekumaran
authors.initials: KS
authors.lastname: Nair
authors.forename: Bengt
authors.initials: B
authors.lastname: Saltin
authors.forename: Ole
authors.initials: O
authors.lastname: Schmitz
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D002950:Citrate (si)-Synthase / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D003576:Electron Transport Complex IV / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005192:Family Health; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D010809:Physical Fitness / Q000502:physiology*; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D003576:Electron Transport Complex IV; D002950:Citrate (si)-Synthase; D010100:Oxygen