Chronic administration of leptin in Asian Blue Quail.
It is well known that leptin has the capacity to reduce food intake, cause body weight loss, and increase energy expenditure in several vertebrate species. In this study, we investigated the effects of chronically elevated leptin levels on behavior and physiology of Asian Blue Quail (Coturnix chinensis). Fifteen male quail were treated with chicken leptin dissolved in phosphate-buffered saline (PBS) via subcutaneously inserted osmotic pumps that released approximately 1 microg/g body weight/day during a 14-day period. Another 15 males acted as controls and their pumps released PBS only. All males were housed together with two females. We observed a decrease in body weight and feeding behavior in leptin-treated birds, but not in control birds, after 2 days of treatment. Thereafter, all birds increased in weight. Males treated with leptin were more active and more likely to preen the day after the beginning of the treatment. Plasma cholesterol levels in leptin birds decreased during the first week of treatment and plasma triglycerides tended to remain lower compared to the controls during the whole 2-week period of treatment. Glucose levels appeared stable during the observation period. Leptin-treated males remained closer to accompanying females than did control males, and females together with leptin males took longer to lay their first egg compared to females together with control males. This is the first article showing the effect of leptin on cholesterol and triglyceride levels in birds. We also observed a change in the activity and male-female interaction pattern in tested quail.
Lõhmus
Mare
M
Department of Zoology, Göteborg University, Sweden. mare.lohmus@zool.gu.se
Sundström
L Fredrik
LF
Silverin
Bengt
B
D000704:Analysis of Variance; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D003370:Coturnix / Q000378:metabolism*; D004334:Drug Administration Schedule; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005260:Female; D015918:Infusion Pumps, Implantable; D020738:Leptin / Q000008:administration & dosage / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010152:Pair Bond; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D020738:Leptin; D014280:Triglycerides; D002784:Cholesterol