title: A triterpenoid saponin possessing antileishmanial activity from the leaves of Careya arborea.
abstract: Bioguided-fractionation of the methanol extract of the leaves of Careya arborea led to isolation of a triterpenoid saponin, designated arborenin, and characterized as 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl-2 alpha,3beta-dihydroxy-taraxast-20-en-28-oic acid (1), together with desacylescin III (2). The structures were determined on the basis of extensive 2D NMR spectroscopic analysis. The saponin showed in vitro antileishmanial activity against Leishmania donovani (strain AG 83).
authors.affiliation: Indian Institute of Chemical Biology, Department of Steroids and Terpenoids Chemistry, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India.
authors.forename: Debayan
authors.initials: D
authors.lastname: Mandal
authors.forename: Nilendu
authors.initials: N
authors.lastname: Panda
authors.forename: Shrabanti
authors.initials: S
authors.lastname: Kumar
authors.forename: Sukdeb
authors.initials: S
authors.lastname: Banerjee
authors.forename: Nirup B
authors.initials: NB
authors.lastname: Mandal
authors.forename: Niranjan P
authors.initials: NP
authors.lastname: Sahu
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D031381:Lecythidaceae / Q000737:chemistry*; D007893:Leishmania donovani / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D012015:Reference Standards; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes