Genotype announcement to Japanese smokers who attended a health checkup examination.
BACKGROUND
Genotype announcement may be one of the effective methods to induce smoking cessation, but the studies are limited throughout the world.


METHODS
Subjects were smokers who attended a health checkup examination provided by a local government in Hokkaido, Japan, 2003. Those who agreed to know their genotypes were informed of the genotypes of glutathione S-transferease (GST) M1 present/null, GSTT1 present/null, and NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T (Pro187Ser).


RESULTS
Out of 143 smokers (92 males and 51 females), 101 individuals participated in the present study. A postal questionnaire one year after the genotype announcement found that 8 persons (6 males and 2 females) of 41 respondents had quitted smoking. Two of 8 quitters stated that they had quitted smoking due to the announcement. There were none who regretted the genotype tests.


CONCLUSIONS
Although the cessation rate, 7.9% (8/101) at least, was not marked, no harmful effects were observed among the respondents.
Hamajima
Nobuyuki
N
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan. nhamajim@med.nagoya-u.ac.jp
Suzuki
Koji
K
Ito
Yoshinori
Y
Kondo
Takaaki
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D030881:Disclosure; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016540:Smoking Cessation
D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; D005982:Glutathione Transferase