title: Heart surgery in infants with hemophilia.
abstract: We describe 2 infants with hemophilia A who had heart surgery under cardiopulmonary bypass with factor VIII replacement therapy, and we recommend a guideline for factor VIII support for cardiac surgery. One child had repair of total anomalous pulmonary venous connection. The second had cardiac catheterization followed by repair of ventricular septal defect and total anomalous pulmonary venous connection. Close collaboration between hematologist, laboratory, cardiologist, and cardiac surgeon is crucial in successful management of coagulation abnormalities during and after surgery.
authors.affiliation: Department of Pediatric Cardiology, Leeds General Infirmary, Leeds, United Kingdom. jothidevi1@hotmail.com
authors.forename: Subramanian Jothi
authors.initials: SJ
authors.lastname: Murugan
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Viswanathan
authors.forename: John
authors.initials: J
authors.lastname: Thomson
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Parsons
authors.forename: Mike
authors.initials: M
authors.lastname: Richards
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control*; D006328:Cardiac Catheterization; D002315:Cardiopulmonary Bypass; D019090:Case Management / Q000592:standards; D000013:Congenital Abnormalities / Q000601:surgery; D005169:Factor VIII / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery*; D006467:Hemophilia A / Q000150:complications*; D006474:Hemorrhagic Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D016343:Monitoring, Intraoperative; D010348:Patient Care Team; D011182:Postoperative Care; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D011300:Preoperative Care; D011667:Pulmonary Veins / Q000002:abnormalities* / Q000601:surgery
chemical_list: C427184:recombinant factor VIII SQ; C078147:F8 protein, human; D005169:Factor VIII