title: Effects of different dietary protein intakes on body composition and vascular reactivity.
abstract: OBJECTIVE
  To assess the effects of a diet rich in protein of animal origin in comparison to one with a protein intake of about 15% of the total daily calories on body composition and arterial function.
  
  
  METHODS
  Randomized prospective study with parallel groups. Body weight (BW), blood pressure (BP), main parameters of carbohydrate and lipid metabolism, body mass composition by bioelectrical impedance analysis, forearm blood flow at rest and in the postischaemic phase by strain gauge plethysmography and flow-mediated dilation of the brachial artery by echography were measured at baseline and after 6 months of the dietary intervention.
  
  
  METHODS
  In total, 15 clinically healthy male volunteers, regularly performing a mixed training three times weekly for 90 min.
  
  
  METHODS
  The participants were randomly prescribed a diet with high (1.9 g/kg BW) or normal (1.3 g/kg BW) protein content.
  
  
  METHODS
  Differences between means were evaluated by the t-tests for paired or unpaired data and by one way analysis of variance. The strength of correlation between variables was investigated by bivariate Pearson correlation.
  
  
  RESULTS
  Serum cholesterol significantly decreased with both diets in comparison to baseline values, whereas BW was slightly but significantly reduced only by the high-protein (HP) diet. No change was detected in BP and the other metabolic parameters. Body mass composition was not significantly modified by either diet. On the other hand, postischaemic flow-mediated dilation of the brachial artery was enhanced by the sole normal protein (NP) diet, whereas no change in the forearm blood flow, both at rest and in the postischaemic phase, was detected.
  
  
  CONCLUSIONS
  These preliminary results indicate that HP diet was found to be not useful in increasing the muscle mass in comparison to a NP intake. In contrast to this, the latter diet seems to enhance the endothelial function of the arterial vessels with a more pronounced dilatation of the lumen in response to the increase in blood flow.
authors.affiliation: Department of Clinical and Experimental Medicine, Federico II University of Naples, Napoli, Italy. ferrara@unina.it
authors.forename: L A
authors.initials: LA
authors.lastname: Ferrara
authors.forename: P
authors.initials: P
authors.lastname: Innelli
authors.forename: V
authors.initials: V
authors.lastname: Palmieri
authors.forename: S
authors.initials: S
authors.lastname: Limauro
authors.forename: G
authors.initials: G
authors.lastname: De Luca
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: E
authors.initials: E
authors.lastname: Liccardo
authors.forename: A
authors.initials: A
authors.lastname: Celentano
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects* / Q000502:physiology; D002784:Cholesterol / Q000097:blood*; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000187:drug effects* / Q000502:physiology; D015431:Weight Loss / Q000187:drug effects
chemical_list: D004044:Dietary Proteins; D002784:Cholesterol