NO-cGMP signaling in development and stem cells.
Despite the recognition that the NO-cGMP signaling pathway is involved in so many physiological and pathological events, a clear understanding of many of the functions of this signaling pathway remains elusive. Because of its pleiotropic and often transient actions, its modulation for therapeutic purposes in multiple pathological states is a complex issue. Recent work that combines the areas of developmental and stem cell biology and NO-cGMP signaling in various models may help us elucidate some of these functions and even discover novel actions for this signaling paradigm. This review will discuss some of the recent work in these areas, with additional focus on the nitric oxide receptor, soluble guanylyl cyclase.
Krumenacker
Joshua S
JS
The Brown Foundation Institute of Molecular Medicine, University of Texas Houston Health Science Center, Houston, 77030, USA.
Murad
Ferid
F
D000818:Animals; D006152:Cyclic GMP / Q000502:physiology*; D047108:Embryonic Development; D006162:Guanylate Cyclase; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000378:metabolism; D015398:Signal Transduction; D000071756:Soluble Guanylyl Cyclase; D013234:Stem Cells / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear; D009569:Nitric Oxide; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase; D006152:Cyclic GMP