title: The long term retention of levetiracetam in a large cohort of patients with epilepsy.
abstract: Levetiracetam (Lev) is a new antiepileptic drug with a distinct mechanism of action, shown in regulatory trials to be effective. These controlled trials do not always predict how useful a drug will be in day to day clinical practice. Retention rates can provide a better indication of efficacy and tolerability in everyday use. Patients attending a tertiary referral centre for epilepsy and who received Lev in the first 2 years of its marketing were assessed (n = 811) to determine continuation rates of treatment with this drug. At the last follow up, 65% of patients were still taking Lev, and the estimated 3 year retention rate was 58%. In total, 11% attained seizure freedom of at least 6 months. Patients taking greater numbers of concurrent antiepileptic drugs (AEDs) were more likely to discontinue Lev, and those reaching higher maximum daily dosages were less likely to discontinue Lev. The retention rate for Lev compares favourably with that of other new AEDs.
authors.affiliation: Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, and the National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Depondt
authors.forename: A W C
authors.initials: AW
authors.lastname: Yuen
authors.forename: G S
authors.initials: GS
authors.lastname: Bell
authors.forename: T
authors.initials: T
authors.lastname: Mitchell
authors.forename: M J
authors.initials: MJ
authors.lastname: Koepp
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan
authors.forename: J W
authors.initials: JW
authors.lastname: Sander
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use*; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D008875:Middle Aged; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam