title: Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium.
abstract: The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.
authors.affiliation: Department of Physiology and Biophysics, University of Miami, School of Medicine, P.O. Box 016430, 1600 NW 10th Avenue, Miami, FL 33136, USA.
authors.forename: Silviu
authors.initials: S
authors.lastname: Locovei
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
authors.forename: Gerhard
authors.initials: G
authors.lastname: Dahl
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects*; D002463:Cell Membrane Permeability / Q000187:drug effects; D017630:Connexins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D009419:Nerve Tissue Proteins; D009865:Oocytes; D018048:Receptors, Purinergic P2 / Q000235:genetics / Q000378:metabolism*; D058472:Receptors, Purinergic P2Y1; D014981:Xenopus
chemical_list: D017630:Connexins; D007295:Inositol Phosphates; D009419:Nerve Tissue Proteins; C546382:P2RY1 protein, human; C492764:PANX1 protein, human; D018048:Receptors, Purinergic P2; D058472:Receptors, Purinergic P2Y1; D000255:Adenosine Triphosphate; D002118:Calcium