Fine-tuning of immune responses by SLAM-related receptors.
The modulation of antigen receptor signals is important for a productive immune response. The main function of the recently identified members of the signaling lymphocyte activating molecule (SLAM)-related receptors (SRR) is the fine-tuning of immune cell activation. Disruption of SRR function is the cause for severe immune disorders such as X-linked lymphoproliferative syndrome (XLP), where XLP patients carry a mutation in SLAM-associated protein (SAP) (SH2D1A), an important adaptor molecule for the signal transduction of SRR. Recent data also suggest that SRR may play a role in autoimmune diseases and the function of hematopoietic stem and progenitor cells. Here, we review the current understanding of SRR function in different immune cells.
Bhat
Rauf
R
Institute for Immunology, University Heidelberg, INF 305, 69120 Heidelberg, Germany.
Eissmann
Philipp
P
Endt
Johanna
J
Hoffmann
Sabrina
S
Watzl
Carsten
C
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007136:Immunoglobulins / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein; D000071176:Signaling Lymphocytic Activation Molecule Family; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1
D015703:Antigens, CD; C084093:CD244 protein, human; D006023:Glycoproteins; D007136:Immunoglobulins; D047908:Intracellular Signaling Peptides and Proteins; C430423:LY9 protein, human; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C114953:SH2D1A protein, human; C448987:SLAMF7 protein, human; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein; D000071176:Signaling Lymphocytic Activation Molecule Family; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1