title: Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.
abstract: A 45-year-old man presented with deep vein thrombosis of the right leg and bilateral pulmonary embolism. Heparin was administered on the initial one and a half days. On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed. The platelet count was 221000/mm3, decreased 42% from the initial level, but remained within the normal range. Heparin was replaced by argatroban on the 13th day. The platelet count increased to 355000/mm3 on the 15th day. The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS). When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.
authors.affiliation: Department of Vascular Surgery, Aichi Medical University, Nagakute, Aichi, Japan. ishibash@aichi-med-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi
authors.forename: O
authors.initials: O
authors.lastname: Takashi
authors.forename: M
authors.initials: M
authors.lastname: Hosaka
authors.forename: I
authors.initials: I
authors.lastname: Sugimoto
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Nihei
authors.forename: J
authors.initials: J
authors.lastname: Kawanishi
authors.forename: T
authors.initials: T
authors.lastname: Ishiguchi
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D005268:Femoral Vein; D005500:Follow-Up Studies; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D011152:Popliteal Vein; D011475:Prosthesis Failure; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D014057:Tomography, X-Ray Computed; D016306:Vena Cava Filters / Q000009:adverse effects*; D014682:Vena Cava, Inferior; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D006493:Heparin