Multifocal Castleman disease in pediatrics: case report.
Multicentric Castleman disease is a rare lymphoproliferative disorder of unknown cause. It is especially rare in children. The authors describe a 4-year-old girl that presented with protracted fever, hypoalbuminemia, thrombocytopenia, anasarca, and disseminated lymphadenopathy. Despite a comprehensive evaluation, her diagnosis remained elusive for several weeks. Eventually, a lymph node biopsy showed the presence of multicentric Castleman disease of mixed type. Due to her relatively poor prognosis and severity of the disease, she was treated with combination chemotherapy consisting of cyclophosphamide, vincristine, doxorubicin, and prednisone. She tolerated her therapy well and is currently free of disease at 36 months of follow-up.
Baserga
Mariana
M
Department of Pediatrics, Children's Hospital of Orange County, Orange, CA, USA.
Rosin
Melissa
M
Schoen
Michael
M
Young
Guy
G
D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011379:Prognosis; D011654:Pulmonary Edema / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D016179:Granulocyte Colony-Stimulating Factor; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone