title: Synthesis and characterization of new fluorene-based singlet oxygen sensitizers.
abstract: The synthesis, photophysical characterization, and determination of singlet oxygen quantum yields (Phi(Delta)) for a class of fluorene derivatives with potential application in two-photon photodynamic therapy (PDT) is reported. It has been demonstrated that these compounds possess the ability to generate singlet oxygen (1O2) upon excitation. A photochemical method, using 1,3-diphenylisobenzofuran (DPBF) as 1O2 chemical quencher, was employed to determine the singlet oxygen quantum yields (Phi(Delta)) of the fluorene-based photosensitizers in ethanol. Phi(Delta) values ranged from 0.35 to 0.75. These derivatives may have potential application as two-photon photosensitizers when pumped via two-photon excitation in the near-IR spectral region.
authors.affiliation: Department of Chemistry and College of Optics & Photonics: CREOL & FPCE, University of Central Florida, P.O. Box 162366, Orlando, Florida 32816-2366, USA. kbelfiel@mail.ucf.edu
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Belfield
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Corredor
authors.forename: Alma R
authors.initials: AR
authors.lastname: Morales
authors.forename: Marie A
authors.initials: MA
authors.lastname: Dessources
authors.forename: Florencio E
authors.initials: FE
authors.lastname: Hernandez
mesh_terms: D001572:Benzofurans / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D005449:Fluorenes / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry; D011789:Quantum Theory; D026082:Singlet Oxygen / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods
chemical_list: D001572:Benzofurans; D005449:Fluorenes; D016877:Oxidants; D017319:Photosensitizing Agents; D012997:Solvents; D026082:Singlet Oxygen; D000431:Ethanol; C041509:fluorene; C011238:1,3-diphenylisobenzofuran