Evidence by molecular profiling for a placental origin of infantile hemangioma.
The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-beta hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium.
Barnés
Carmen M
CM
Vascular Biology Program and Department of Surgery, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Huang
Sui
S
Kaipainen
Arja
A
Sanoudou
Despina
D
Chen
Emy J
EJ
Eichler
Gabriel S
GS
Guo
Yuchun
Y
Yu
Ying
Y
Ingber
Donald E
DE
Mulliken
John B
JB
Beggs
Alan H
AH
Folkman
Judah
J
Fishman
Steven J
SJ
D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics; D016000:Cluster Analysis; D030541:Databases, Genetic; D004730:Endothelium, Vascular / Q000473:pathology; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000235:genetics; D006391:Hemangioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology; D010920:Placenta / Q000378:metabolism / Q000473:pathology*; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014018:Tissue Distribution; D019043:Vascular Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*
D006023:Glycoproteins; D012333:RNA, Messenger; C021240:tissue-factor-pathway inhibitor 2; D012313:RNA; D015067:17-Hydroxysteroid Dehydrogenases