title: A sigma28-regulated nonflagella gene contributes to virulence of Campylobacter jejuni 81-176.
abstract: A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure.
authors.affiliation: Enteric Diseases Dept., Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
authors.forename: Scarlett
authors.initials: S
authors.lastname: Goon
authors.forename: Cheryl P
authors.initials: CP
authors.lastname: Ewing
authors.forename: Maria
authors.initials: M
authors.lastname: Lorenzo
authors.forename: Dawn
authors.initials: D
authors.lastname: Pattarini
authors.forename: Gary
authors.initials: G
authors.lastname: Majam
authors.forename: Patricia
authors.initials: P
authors.lastname: Guerry
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002169:Campylobacter Infections / Q000378:metabolism*; D016123:Campylobacter jejuni / Q000235:genetics* / Q000472:pathogenicity / Q000648:ultrastructure; D004195:Disease Models, Animal; D005289:Ferrets / Q000382:microbiology; D009154:Mutation; D012808:Sigma Factor / Q000502:physiology*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; C064971:FliA protein, Bacteria; D012808:Sigma Factor; D037521:Virulence Factors