HPV-associated skin disease.
Human papillomaviruses (HPVs) are DNA tumour viruses that induce hyperproliferative lesions in cutaneous and mucosal epithelia. The relationship between HPV and non-melanoma skin cancer (NMSC) is important clinically since NMSC is the most common form of malignancy among fair-skinned populations. It is well established that solar ultraviolet (UV) irradiation is the major risk factor for developing NMSC, but a pathogenic role for HPV in the development of NMSC has also been proposed. Recent molecular studies reveal a likely role for HPV infection in skin carcinogenesis as a co-factor in association with UV. This review summarizes the literature describing these data, highlights some of the important findings derived from these studies, and speculates on future perspectives.
Akgül
Baki
B
Skin Tumour Laboratory, Cancer Research UK, London.
Cooke
James C
JC
Storey
Alan
A
D000818:Animals; D030801:Animals, Genetically Modified; D017209:Apoptosis / Q000528:radiation effects; D002453:Cell Cycle / Q000502:physiology; D002478:Cells, Cultured; D004260:DNA Repair / Q000235:genetics; D004819:Epidermodysplasia Verruciformis / Q000821:virology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D015603:Keratinocytes / Q000821:virology; D027383:Papillomaviridae / Q000502:physiology / Q000528:radiation effects; D030361:Papillomavirus Infections / Q000150:complications*; D012874:Skin Diseases, Infectious / Q000150:complications* / Q000821:virology; D012878:Skin Neoplasms / Q000235:genetics / Q000821:virology*; D014466:Ultraviolet Rays / Q000009:adverse effects