title: A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report.
abstract: BACKGROUND
  Post-transplant malignancies are among the most important complications in organ transplantation. Hemangioblastoma (HB) is especially prevalent in the cerebellum.
  
  
  METHODS
  A 20-year-old male who first started dialysis therapy, and then underwent kidney transplantation from a living-relative donor. Five years after transplantation, the patient suffered from vertigo and imbalance when walking. On cranial magnetic resonance imaging (MRI), a mass lesion in the right cerebellar hemisphere was observed, 3 x 3 x 3 cm in size, which was pushing against the fourth ventricle, and the right cerebellar peduncle. The patient had significant hydrocephaly. The mass lesion was removed by craniectomy. The pathological diagnosis was cerebellar hemangioblastoma. The symptoms and clinical findings improved. The patient was diagnosed with sporadic hemangioblastoma. Rapamycin therapy was started instead of cyclosporine, and the patient is being followed up without further problems.
  
  
  CONCLUSIONS
  HB causes 2% of all intracranial tumors in the general population. It is generally sporadic in nature and approximately 20% can be associated with von Hippel-Lindau (VHL) syndrome. As in this case, MRI is preferred for the diagnosis. There was no pathology related to VHL disease in this patient's physical examination, family history, routine biochemical tests and abdominal MRI. The treatment is surgical excision of the tumor, as in this case.
  
  
  CONCLUSIONS
  When cerebellar symptoms occur or a cerebellar mass lesion is detected in an organ recipient, HB should be considered in the differential diagnosis. The examination of patients with HB for a possible association with VHL disease is also required.
authors.affiliation: Division of Nephrology, Istanbul Faculty of Medicine, Internal Medicine, Istanbul University, Istanbul - Turkey. savasozturkdr@yahoo.com
authors.forename: Savaş
authors.initials: S
authors.lastname: Oztürk
authors.forename: Ozlem
authors.initials: O
authors.lastname: Soyluk
authors.forename: Serpil
authors.initials: S
authors.lastname: Görçin
authors.forename: Sabahat
authors.initials: S
authors.lastname: Alişir
authors.forename: Dilek
authors.initials: D
authors.lastname: Güven
authors.forename: Aydin
authors.initials: A
authors.lastname: Türkmen
authors.forename: Mehmet S
authors.initials: MS
authors.lastname: Sever
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D003399:Craniotomy; D005500:Follow-Up Studies; D018325:Hemangioblastoma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male