Effects of sleep deprivation on cortical excitability in patients affected by juvenile myoclonic epilepsy: a combined transcranial magnetic stimulation and EEG study.
OBJECTIVE
To investigate the effect of sleep deprivation on corticospinal excitability in patients affected by juvenile myoclonic epilepsy (JME) using different transcranial magnetic stimulation (TMS) parameters.


METHODS
Ten patients with JME and 10 normal subjects underwent partial sleep deprivation. Motor threshold (MT), motor evoked potential amplitude (MEP), and silent period (SP) were recorded from the thenar eminence (TE) muscles. Short latency intracortical inhibition (SICI) and short latency intracortical facilitation (SICF) were studied using paired magnetic stimulation. TMS was performed before and after sleep deprivation; EEG and TMS were performed simultaneously.


RESULTS
In patients with JME, sleep deprivation induced a significant decrease in SICI and an increase in SICF, which was associated with increased paroxysmal activity. A significant decrease in the MT was observed. No significant changes in any TMS parameters were noted in normal subjects after sleep deprivation. The F wave was unchanged by sleep deprivation in both control subjects and in patients with JME.


CONCLUSIONS
In patients with JME, sleep deprivation produces increases in corticospinal excitability in motor areas as measured by different TMS parameters.
Manganotti
P
P
Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Policlinico Borgo Roma, Via delle Menegone, 37134 Verona, Italy. paolo.manganotti@univr.it
Bongiovanni
L G
LG
Fuggetta
G
G
Zanette
G
G
Fiaschi
A
A
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D012892:Sleep Deprivation / Q000150:complications* / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation