title: Protein complexes regulating Arp2/3-mediated actin assembly.
abstract: Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3 complex and formins are the best studied. Arp2/3-complex activity is controlled through signalling-dependent association with nucleation-promoting factors, such as the WASP/WAVE family proteins. A common theme for these molecules, which is well established for WAVEs but is only just beginning to emerge for WASPs, is that they act as coincident detectors of a variety of signalling pathways through the formation of large multi-molecular complexes.
authors.affiliation: Signalling and Motility Group, German Research Centre for Biotechnology (GBF), Mascheroder Weg 1, D-38124 Braunschweig, Germany. ths@gbf.de
authors.forename: Theresia E B
authors.initials: TE
authors.lastname: Stradal
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scita
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism / Q000502:physiology*; D000199:Actins / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D001704:Biopolymers; D022081:Cell Surface Extensions / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D051300:Wiskott-Aldrich Syndrome Protein Family / Q000378:metabolism / Q000502:physiology*
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D001704:Biopolymers; D051300:Wiskott-Aldrich Syndrome Protein Family