title: Thin basement membrane nephropathy associated with minimal change disease in a 15-year-old boy.
abstract: Thin basement membrane nephropathy (TBMN) is characterized clinically by persistent hematuria, minimal proteinuria, normal renal function, another family member with hematuria, and a benign course. Especially in childhood TBMN, proteinuria of any degree is reported to be uncommon. We report on a boy with benign familial hematuria found by urinary screening at 3 years of age who presented with nephrotic syndrome (NS) at 15 years of age. His renal histology showed TBMN associated with minimal change disease (MCD). Treatment with corticosteroid resulted in complete remission of NS in a short period of time, while isolated hematuria persisted during the follow-up period despite this therapy. We speculate, therefore, that the nephrotic range proteinuria is not due to TBMN but rather is the manifestation of associated MCD. Several cases of TBMN with NS have been reported in adults, but it has not yet been reported in children in the literature. To our knowledge, this is the first case of childhood TBMN associated with NS resulting from coincidental MCD.
authors.affiliation: Division of Nephrology, Saitama Children's Medical Center, Japan. f_shuich@d2.dion.ne.jp
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Fujinaga
authors.forename: Kazunari
authors.initials: K
authors.lastname: Kaneko
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ohtomo
authors.forename: Hitohiko
authors.initials: H
authors.lastname: Murakami
authors.forename: Mayako
authors.initials: M
authors.lastname: Takemoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Takada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamashiro
mesh_terms: D000293:Adolescent; D001485:Basement Membrane / Q000473:pathology* / Q000648:ultrastructure; D002675:Child, Preschool; D005500:Follow-Up Studies; D006417:Hematuria / Q000150:complications*; D006801:Humans; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000473:pathology; D009404:Nephrotic Syndrome / Q000150:complications*