Alpha-peptide/beta-sulfonamidopeptide hybrids: analogs of the chemotactic agent for-Met-Leu-Phe-OMe.
In order to gain information on the activity shown by alpha-peptide/beta-sulfonamidopeptide hybrid analogs of the potent chemotactic agent fMLF-OMe, a structure-activity study is reported on N-Boc- and N-formyl tripeptide models containing an aminoalkanesulfonic acid as central residue. Directed migration (chemotaxis), superoxide anion production, and lysozyme release have been measured. The biochemical functions and the conformational properties of the new compounds are discussed and related to previously studied models containing beta-residues.
Giordano
Cesare
C
Dipartimento di Studi farmaceutici, Università di Roma La Sapienza and Istituto di Chimica Biomolecolare del CNR, Sezione di Roma, P.le A. Moro 5, 00185 Roma, Italy. cesare.giordano@uniroma1.it
Lucente
Gino
G
Masi
Annalisa
A
Paradisi
Mario Paglialunga
MP
Sansone
Anna
A
Spisani
Susanna
S
D002478:Cells, Cultured; D002630:Chemotactic Factors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*
D002630:Chemotactic Factors; D009842:Oligopeptides; D013449:Sulfonamides