Self-assembling a molecular pegboard.
This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a "molecular pegboard". We used the indexed DNA nanogrids to identify single molecules of DNA that hybridize at particular locations.
Lund
Kyle
K
Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA.
Liu
Yan
Y
Lindsay
Stuart
S
Yan
Hao
H
D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D046228:Microarray Analysis; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D019809:Streptavidin / Q000737:chemistry
D004247:DNA; D019809:Streptavidin