[Cryptococcal infections in non-HIV infected patients. Study of four cases and review of literature].
BACKGROUND
Cryptococcal infections are frequent in HIV-infected patients and are regularly looked after. This infection may occur in others immunosuppressives situations and, in those cases, diagnosis is often delayed.


METHODS
We report four cases of cryptococcal infections in patients whose immunosuppression isn't related with HIV infection but due to chronic lymphocytic leukemia, giant cell temporal arteritis, gastric neoplasm and lupus. Diagnosis, prognostic and treatment are detailed.


RESULTS
Four patients aged from 25 to 76 presented a cryptococcal infection (three meningitis). A woman died at the admission. Another died seven years later. The two others are still alive under treatment. When infected, all patients were immunodeficiency.


CONCLUSIONS
Cryptococcal infection may occur in patients non-HIV-infected patients. Early detection is needed to improve prognostic.
Revest
M
M
Service de Médecine Interne, Département de Médecine de l'Adulte, Hôpital Sud, 16, boulevard de Bulgarie, 35203 Rennes cedex, France.
Decaux
O
O
Frouget
T
T
Cazalets
C
C
Albert
J D
JD
Chevrier
S
S
Guiguen
C
C
Jego
P
P
Grosbois
B
B
D000328:Adult; D000368:Aged; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications; D018023:HIV Seronegativity; D006801:Humans; D016867:Immunocompromised Host; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications; D008177:Lupus Vulgaris / Q000150:complications; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis* / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000150:complications