title: Transfusions of CPDA-1 red blood cells stored for up to 28 days decrease donor exposures in very low-birth-weight premature infants.
abstract: The goal of this research was to study the safety and the efficacy of transfusing citrate-phosphate-adenine anticoagulant-preservative (CPDA-1) RBC stored for up to 28 days to reduce donor exposures in premature infants. A prospective randomized two-group study was conducted with very low-birth-weight premature infants that received at least one RBC transfusion during hospital stay. Neonates randomly assigned to Group 1 (26 infants) were transfused with CPDA-1 RBC stored for up to 28 days; those assigned to Group 2 (26 infants) received CPDA-1 RBC stored for up to 3 days. Demographic and transfusion-related data were collected. Neonates from both groups showed similar demographics and clinical characteristics. The number of transfusions per infant transfused was 4.4 +/- 4.0 in Group 1 and 4.2 +/- 3.1 in Group 2, and the number of donors per infant transfused was 1.5 +/- 0.8 (Group 1) and 4.3 +/- 3.4 (Group 2), P < 0.001. RBC transfusions containing 29.7 +/- 18.3 mmol L(-1) of potassium (RBC stored for up to 28 days) did not cause clinical or biochemical changes and reduced donor exposures by 70.2%, compared to transfusions containing 19.8 +/- 12.3 mmol L(-1) of potassium (RBC stored for up to 3 days), P < 0.001. In conclusion, RBC stored for up to 28 days safely reduced donor exposures in premature infants.
authors.affiliation: Division of Neonatal Medicine, Department of Pediatrics, Hematology and Transfusion Medicine Service, Department of Biostatistics, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: D H
authors.initials: DH
authors.lastname: Fernandes da Cunha
authors.forename: A M
authors.initials: AM
authors.lastname: Nunes Dos Santos
authors.forename: B I
authors.initials: BI
authors.lastname: Kopelman
authors.forename: K N
authors.initials: KN
authors.lastname: Areco
authors.forename: R
authors.initials: R
authors.lastname: Guinsburg
authors.forename: C
authors.initials: C
authors.lastname: de Araújo Peres
authors.forename: A K
authors.initials: AK
authors.lastname: Chiba
authors.forename: S T
authors.initials: ST
authors.lastname: Kuwano
authors.forename: C C N
authors.initials: CC
authors.lastname: Terzian
authors.forename: J O
authors.initials: JO
authors.lastname: Bordin
mesh_terms: D000225:Adenine; D001774:Blood Chemical Analysis; D001782:Blood Donors; D001793:Blood Preservation / Q000379:methods*; D002951:Citrates; D003257:Consumer Product Safety; D017707:Erythrocyte Transfusion / Q000379:methods* / Q000592:standards; D005947:Glucose; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D010710:Phosphates; D013997:Time Factors
chemical_list: C034876:CPDA solutions; D002951:Citrates; D010710:Phosphates; D005947:Glucose; D000225:Adenine