Common pitfalls in the conduct of clinical research.
Recently, paradigm shift from expert opinion towards evidence-based medicine has occurred encouraging physicians to base their treatment decisions on the best available research evidence. In the hierarchy of evidence randomized clinical trials (level 1 evidence) are considered of the highest quality (least biased) while non-randomized studies represent lower levels (levels 2-4). Several pitfalls in the design and conduct of clinical research include: lack of randomization, lack of concealment, lack of blinding, and errors in hypothesis testing (type I and II errors). A basic understanding of these principles of research will empower both investigators and readers when applying the results of research to clinical practice.
Zlowodzki
Michael
M
Division of Orthopaedic Surgery, McMaster University, Hamilton, Canada.
Jonsson
Anders
A
Bhandari
Mohit
M
D035843:Biomedical Research / Q000458:organization & administration*; D019317:Evidence-Based Medicine; D005602:France; D006801:Humans; D012107:Research Design