title: Clinicopathological prognostic factors of adult granulosa cell tumor of the ovary--a study of 37 cases.
abstract: Adult granulosa cell tumor (GCT) of the ovary is the most common malignancy amongst the sex cord stromal tumors. Clinical stage, age, tumor size, residual disease and several histologic factors have been reported to be of prognostic significance. There were 839 ovarian malignancies at our institute during the period from 1998 to 2002. Out of 54 granulosa cell tumors, 40 cases were evaluable which includes 37 cases of adult GCT and 3 cases of juvenile GCT. They were studied retrospectively. Majority of patients presented with abdominal symptoms and FIGO stage I. All patients were treated surgically and 62.1% of adult GCTs were given post-operative chemotherapy. Clinical stage, presence of residual disease and tumor volume were the most important prognostic factors. Age of patient, menstrual status, post-operative chemotherapy, mitosis or histological patterns were of little significance in our study.
authors.affiliation: Department of Pathology, Gujarat Cancer & Research Institute, Civil Hospital Campus, Asarwa, Ahmedabad. himanshumehta_in@yahoo.com
authors.forename: Himanshu
authors.initials: H
authors.lastname: Mehta
authors.forename: Priti
authors.initials: P
authors.lastname: Trivedi
authors.forename: Biren
authors.initials: B
authors.lastname: Parikh
authors.forename: Kaushambi
authors.initials: K
authors.lastname: Shukla
authors.forename: M J
authors.initials: MJ
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006106:Granulosa Cell Tumor / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate