Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell.
Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.
Kang
Jee Hyun
JH
Department of Family Medicine, College of Medicine, Konyang University, Daejon 320-718, Korea.
Lee
Yoon Young
YY
Yu
Byung Yeon
BY
Yang
Beom-Seok
BS
Cho
Kyung-Hwan
KH
Yoon
Do Kyoung
DK
Roh
Yong Kyun
YK
D052242:Adiponectin / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000473:pathology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D010957:Plasmids / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles
D052242:Adiponectin; D011994:Recombinant Proteins; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue