Effects of calcipotriol cream and ointment, clobetasol cream and ointment and tretinoin cream on the erythemogenicity of UVB.
Various studies have shown the blocking effects of topical agents on UVB penetration, which can be used in combination with phototherapy. In this study, the photoprotective effects of 0.005% calcipotriol, 0.05% clobetasol-17-propionate, and 0.1% tretinoin, which can be used in combination with broad-band UVB, were investigated in an in vivo test. In a study group of 20 patients, phototests were performed to determine minimal erythema doses (MED) and the tests were repeated with thin (0.1 cc/25 cm2) and thick (0.3 cc/25 cm2) calcipotriol, clobetasol-17-propionate, and tretinoin in cream forms and sunscreen. After determining the MED, the test was repeated in another 20 patients with thin and thick calcipotriol and clobetasol-17-propionate in both cream and ointment forms and sunscreen. MED was increased with thin and thick applications of all agents. Moreover, the photoprotective effects of each agent increased with their thick applications compared with thin ones. The application of calcipotriol cream and ointment, clobetasol cream and ointment, and tretinoin cream, all of which can block UVB, is not recommended just before phototherapy.
Fetil
Emel
E
Department of Dermatology, Faculty of Medicine, University of Dokuz Eylül, Izmir, Turkey.
Ilknur
Turna
T
Altiner
Didem
D
Ozkan
Sebnem
S
Güneş
Ali Tahsin
AT
D000328:Adult; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004890:Erythema / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D009824:Ointments; D012016:Reference Values; D016037:Single-Blind Method; D014212:Tretinoin / Q000627:therapeutic use*; D014466:Ultraviolet Rays
D003879:Dermatologic Agents; D009824:Ointments; C055085:calcipotriene; D014212:Tretinoin; D002990:Clobetasol; D002117:Calcitriol