title: Leptin and its receptors in human fetal and adult ovaries.
abstract: The objective of the study was to investigate the immunocytochemical expression and presence of messenger RNA (mRNA) transcripts for leptin and its receptors in ovaries from human adults and adolescents and second- and third-trimester fetuses. Staining for leptin and the long form of its receptor was identified in oocytes of follicles from primordial stages onward, and for leptin only in granulosa cells of a minority of the samples. Expression of mRNA transcripts for both ligands was detected in all the samples tested.
authors.affiliation: Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel. ronita@clalit.org.il
authors.forename: Ronit
authors.initials: R
authors.lastname: Abir
authors.forename: Asangla
authors.initials: A
authors.lastname: Ao
authors.forename: Shaoguang
authors.initials: S
authors.lastname: Jin
authors.forename: Miriam
authors.initials: M
authors.lastname: Barnett
authors.forename: Hila
authors.initials: H
authors.lastname: Raanani
authors.forename: Avi
authors.initials: A
authors.lastname: Ben-Haroush
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fisch
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015870:Gene Expression; D005865:Gestational Age; D006107:Granulosa Cells / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D020738:Leptin / Q000235:genetics* / Q000378:metabolism; D008024:Ligands; D009865:Oocytes / Q000502:physiology; D006080:Ovarian Follicle / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D054411:Receptors, Leptin
chemical_list: C515448:LEPR protein, human; D020738:Leptin; D008024:Ligands; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin