SNEP: SNP-derived epitope prediction program for minor H antigens.
The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIANT or CONFLICT in SWISS-PROT) and predicts potential T-cell epitopes within a chosen distance around the polymorphic residue. The prediction algorithm is based on the SYFPEITHI T-cell epitope prediction program. SNEP is able to search for proteins according to their accession numbers, sequence stretches or gene names, for example. The predictions are available for several human leucocyte antigen class I and class II allelic products, which allow for a rapid and precise evaluation of potential miHAgs within polymorphic antigens.
Schuler
Mathias M
MM
Abteilung Immunologie, Interfakultäres Institut für Zellbiologie, Universität Tübingen, Germany.
Dönnes
Pierre
P
Nastke
Maria-Dorothea
MD
Kohlbacher
Oliver
O
Rammensee
Hans-Georg
HG
Stevanovic
Stefan
S
D000595:Amino Acid Sequence; D003627:Data Interpretation, Statistical; D030562:Databases, Protein; D018984:Epitopes, T-Lymphocyte / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D012984:Software
D018984:Epitopes, T-Lymphocyte; D006680:HLA Antigens; D015778:Minor Histocompatibility Antigens