Routine computed tomography screening of the chest in high-risk cardiac transplant recipients may improve survival.
BACKGROUND
Multiple studies have demonstrated an increased incidence of lung cancer in the heart transplant population. We reviewed our cardiac transplantation experience with respect to the development of bronchogenic carcinoma and explored the role of routine chest computed tomography (CT) in its surveillance.


METHODS
We performed a review of our cardiac transplantation experience, highlighting the incidence of lung cancer, and we analyzed our recent experience with screening chest CT in lung cancer surveillance in this patient group.


RESULTS
Eighteen patients developed 20 cases of bronchogenic carcinoma for an incidence of 6.83%. In 10 cases, the patients underwent surgical resection; however, in the remaining cases, the patients were either treated with chemotherapy and/or radiation or they died before initiation of therapy. The actuarial 1-, 2- and 5-year overall survival rates were 49%, 29% and 13%, respectively. The median survival of patients who underwent surgical resection was 28 months (3 to 85 months), whereas the median survival of patients who were either ineligible for surgery or died before initiation of treatment was only 1 month (1 to 13 months). All patients diagnosed with lung cancer by chest CT underwent surgical resection; however, only 37.5% of patients diagnosed with lung cancer by chest X-ray were found at an appropriate stage for resection (p = 0.025).


CONCLUSIONS
Cardiac transplant recipients have a significant risk of developing bronchogenic carcinoma. Routine chest CT screening in high-risk patients may enable clinicians to identify disease earlier, which is essential for the option of surgical resection and, therefore, prolonged survival.
Rosenbaum
David H
DH
Department of Thoracic and Cardiovascular Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8879, USA.
Bhojani
Rehal A
RA
Dikmen
Erkan
E
Kaiser
Patricia A
PA
Paul
Michelle C
MC
Wait
Michael A
MA
Meyer
Dan M
DM
Jessen
Michael E
ME
Yancy
Clyde W
CW
Rosenblatt
Randall L
RL
Torres
Fernando
F
Perkins
Steve
S
Ring
W Steves
WS
DiMaio
J Michael
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011379:Prognosis; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed