title: Efficacy of vaccination against Fusobacterium necrophorum infection for control of liver abscesses and footrot in feedlot cattle in western Canada.
abstract: A randomized and blinded field trial was carried out to evaluate the efficacy of a Fusobacterium necrophorum bacterin for control of liver abscesses and footrot under commercial feedlot conditions in western Canada. Half of the vaccinated and half of the unvaccinated control animals had ad libitum access to a forage-based (ALF) growing diet. The other half of each group was limit-fed a grain-based (LFG) growing diet. The overall prevalence of A and A+ liver abscesses in this trial was 16.7%. A strong association was found between diet group and presence of A or A+ liver abscessation at slaughter. Diet group modified the effect of vaccination on the prevalence of liver abscesses at slaughter, and on the incidence of footrot during the feeding period. The odds that a vaccinated animal in the ALF group would have an A or A+ liver abscess at slaughter were less than 1/3 the odds that an unvaccinated animal in the same diet group would have an A or A+ liver abscess at slaughter (OR = 0.27, [95% CI: 0.07 to 1.02], P = 0.05). The overall incidence of footrot in this trial was 6.5%. The odds that a vaccinated animal in the ALF group would be treated for footrot were less than 1/5 the odds that an unvaccinated animal in the same group would be treated for foot-rot (OR = 0.18, [95% CI: 0.04 to 0.82], P = 0.03). Within the LFG group there were no differences between vaccinated and unvaccinated animals in the odds of an animal being treated for footrot, or in the odds of having an A or A+ liver abscess score at slaughter. This trial suggests that vaccination against F. necrophorum infection may have applications to decrease the prevalence of severe liver abscesses at slaughter and decrease footrot treatments in certain diet situations.
authors.affiliation: Food Safety Division Alberta Agriculture, Food and Rural Development, 116B, 6909-116 Street, Edmonton, Alberta. sylvia.checkley@gov.ab.ca
authors.forename: Sylvia L
authors.initials: SL
authors.lastname: Checkley
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Janzen
authors.forename: John R
authors.initials: JR
authors.lastname: Campbell
authors.forename: John J
authors.initials: JJ
authors.lastname: McKinnon
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002170:Canada / Q000453:epidemiology; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005535:Foot Rot / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D005674:Fusobacterium Infections / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D005675:Fusobacterium necrophorum / Q000276:immunology* / Q000302:isolation & purification; D015994:Incidence; D008100:Liver Abscess / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D016017:Odds Ratio
chemical_list: D001428:Bacterial Vaccines