title: Recurrence of high-grade squamous intraepithelial neoplasia in neovagina: case report and review of the literature.
abstract: Recurrent carcinoma in situ in neovagina is rare, and the optimal modality of treatment is unclear. A 33-year-old multiparous woman was referred for vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, and cervical intraepithelial neoplasia, underwent skinning vulvectomy with perianal excision, total vaginectomy, vaginal hysterectomy, and vaginal reconstruction with split-thickness skin graft. Ten years after initial surgery, the recurrence as a high-grade intraepithelial neoplasia in the upper one third of neovagina was detected. For that reason, the upper one third of vaginectomy with at least 5-mm tumor-free border and vaginal reconstruction with split-thickness skin graft were performed. She has attended her regular follow-up for 3 years with no evidence of disease. All patients with vaginoplasty should undergo regular follow-up. This report is the seventh such report in English literature of patients previously treated for in situ carcinoma who later developed recurrence in the graft.
authors.affiliation: Department of Obstetrics and Gynecology and Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. suleymanguven@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Guven
authors.forename: E S
authors.initials: ES
authors.lastname: Guvendag Guven
authors.forename: A
authors.initials: A
authors.lastname: Ayhan
authors.forename: A
authors.initials: A
authors.lastname: Gokoz
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000601:surgery*; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D019651:Plastic Surgery Procedures; D012086:Reoperation; D016038:Skin Transplantation; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000601:surgery*; D014846:Vulvar Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery