Bone morphogenetic protein 7 in the treatment of congenital pseudarthrosis of the tibia.
We describe a 13-year-old boy with atrophic tibial pseudarthrosis associated with neurofibromatosis who had undergone nine unsuccessful operations. Eventually, union was obtained by the use of bone morphogenetic protein 7 in conjunction with intramedullary stabilisation and autologous bone graft.
Fabeck
L
L
Department of Orthopaedic Surgery, CHU Saint Pierre, 322 rue Haute, 1000 Brussels, Belgium. laurent_fabeck@stpierre-bru.be
Ghafil
D
D
Gerroudj
M
M
Baillon
R
R
Delincé
Ph
P
D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005360:Fibula / Q000293:injuries; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D017253:Neurofibromatoses / Q000150:complications; D011542:Pseudarthrosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D011859:Radiography; D013977:Tibia / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery; D013978:Tibial Fractures / Q000628:therapy; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta