Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.
Charge delocalization (6+ to 8+) in "noncovalent" linear trinuclear platinum complexes produces compounds with cytotoxicity in some cases equivalent to cisplatin. The cellular uptake of a novel 8+ compound is greater than that of neutral cisplatin as well as other multinuclear Pt compounds.
Harris
Amanda L
AL
Chemistry Department, Virginia Commonwealth University, 1001 W. Main Street, Richmond, Virginia 23284-2006, USA.
Yang
Xiaohong
X
Hegmans
Alex
A
Povirk
Lawrence
L
Ryan
John J
JJ
Kelland
Lloyd
L
Farrell
Nicholas P
NP
D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*
D017671:Platinum Compounds