Thrombotic and nonthrombotic hepatic artery complications in adults and children following primary liver transplantation with long-term follow-up in 1000 consecutive patients.
Arterial complications have a major impact on survival after liver transplantation (LTx). The aim of this study was to examine arterial complications in adults and children after LTx. A total of 1000 consecutive primary LTx patients [mean age 40.5 years: 600 males, 400 females, 834 adults; 166 children (age <18 years)] were studied. Forty-two patients (4.2%; 31 adults, 11 children) developed hepatic artery thrombosis (HAT). Thrombosis in children occurred significantly early (mean 5.4 days) compared with adults (mean 418.7 days, P = 0.0001). Nonthrombotic complications occurred in 30 patients (29 adults, one child). Overall, 13-year patient survival after HAT was 43.2% (72.7% children, 32.9% adults). For nonthrombotic complications, 54.3% of adults died and 69.4% grafts were lost. An overall incidence of 4.2% thrombotic and 3.2% nonthrombotic complications was observed. Rate of HAT was higher in children, but survival was better compared with adults.
Jain
Ashokkumar
A
Department of Surgery, Division of Transplantation, University of Rochester Medical Centre, Rochester, NY 14642, USA. ashok_jain@urmc.rochester.edu
Costa
Guilherme
G
Marsh
Wallis
W
Fontes
Paulo
P
Devera
Michael
M
Mazariegos
George
G
Reyes
Jorge
J
Patel
Kusum
K
Mohanka
Ravi
R
Gadomski
Mary
M
Fung
John
J
Marcos
Amadeo
A
D000293:Adolescent; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000453:epidemiology*; D002648:Child; D005500:Follow-Up Studies; D006499:Hepatic Artery / Q000473:pathology*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000502:physiology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000145:classification*; D012189:Retrospective Studies; D013927:Thrombosis / Q000453:epidemiology*; D013997:Time Factors; D016896:Treatment Outcome