[Temporal changes of diffusion-weighted MR images in a patient with transient global amnesia].
The pathogenesis of transient global amnesia (TGA) remains uncertain, although it is featured by characteristic clinical symptoms. We present a patient with TGA, in which diffusion-weighted MR image showed a punctuate hyperintense lesion in the left CA1 subfield of the hippocampus adjoining the lateral ventricle 24 hours after the onset. This lesion was observed with FLAIR image after 9 days from the onset, and therefore was considered to be a delayed ischemic lesion. A SPECT and PET studies 7 days after the onset showed a decrease of the CBF, CMRO2 and CMRglu, and was compatible with a delayed ischemic lesion. However, there were no cardiovascular risk factors nor abnormalities of vascular supply, and therefore the reason for microcirculatory disturbances remained unclear.
Matsui
Yusuke
Y
Department of Neurology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Saiki
Hidemoto
H
Tomimoto
Hidekazu
H
Takahashi
Ryosuke
R
Miki
Yukio
Y
Fukuyama
Hidenao
H
D020236:Amnesia, Transient Global / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging; D019788:Fluorodeoxyglucose F18; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013702:Temporal Lobe / Q000473:pathology
D019788:Fluorodeoxyglucose F18