title: Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions.
abstract: [structure: see text] The binding affinities of a cholic-acid-based fluorescent neutral receptor toward dicarboxylate anions and amino acids have been investigated in a CH3OH/H2O system (1:1, 0.01 M HEPES buffer, pH = 7.4) by fluorescence titration experiments. The synthetic host bearing four convergent functionalities strongly binds glutamate via multiple hydrogen bonds with a binding constant of (5.57 +/- 0.88) x 10(6).
authors.affiliation: Department of Chemistry, Wuhan University, Hubei, China.
authors.forename: Shun-Ying
authors.initials: SY
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Fang
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: He
authors.forename: Wing-Hong
authors.initials: WH
authors.lastname: Chan
authors.forename: Kai-Tai
authors.initials: KT
authors.lastname: Yeung
authors.forename: Yuen-Kit
authors.initials: YK
authors.lastname: Cheng
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Yang
mesh_terms: D024342:Amino Acids, Acidic / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D001665:Binding Sites; D015374:Biosensing Techniques / Q000379:methods*; D002793:Cholic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D005453:Fluorescence; D005971:Glutamates / Q000737:chemistry; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D014867:Water / Q000737:chemistry
chemical_list: D024342:Amino Acids, Acidic; D000838:Anions; D002793:Cholic Acids; D003998:Dicarboxylic Acids; D005971:Glutamates; D014867:Water