title: Stereocontrolled synthesis of (-)-kainic acid from trans-4-hydroxy-L-proline.
abstract: [reaction: see text] A highly stereoselective synthesis of (-)-kainic acid has been achieved in 14 steps and >7% overall yield starting from inexpensive trans-4-hydroxy-L-proline. The key steps are diastereoselective enolate alkylation and cuprate substitution reactions.
authors.affiliation: Chimie Recherche (LEDSS), Université Joseph Fourier, 38041 Grenoble, France jean-francois.poisson@ujf-grenoble.fr
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Poisson
authors.forename: Arturo
authors.initials: A
authors.lastname: Orellana
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Greene