title: Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks.
abstract: Molecular chaperones (heat shock proteins) are important components of cellular networks, such as protein-protein and gene regulatory networks. Chaperones participate in the folding of immunologically important proteins, presentation of antigens and activation of the immune system. Here, we propose that chaperone-related immune dysfunction might be more general than was previously thought. Mutations and polymorphism of chaperones and the regulators of their synthesis, heat shock factor-1, chaperone diseases, sick chaperones and chaperone overload might all affect (mostly impairing) immune responses.
authors.affiliation: Department of Medical Chemistry, Semmelweis University, H-1088 Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Nardai
authors.forename: Eszter M
authors.initials: EM
authors.lastname: Végh
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Prohászka
authors.forename: Péter
authors.initials: P
authors.lastname: Csermely
mesh_terms: D000818:Animals; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011485:Protein Binding
chemical_list: D018832:Molecular Chaperones