Approach to novel functional foods for stress control: 1. Toward structure-activity relationship and data mining of food compounds by chemoinformatics.
Over the past several decades, thousands of natural organic compounds have been isolated from foods, and the information about their structures and biological activities has been accumulated. Despite the long research history of food products and their potential great promise as a medicine and functional food, the systematic research and development have not been carried out extensively. For understanding of the comprehensive structure-activity relationship, we have developed the database system of flavonoids, which are frequently found in vegetables and fruits. We also plan to execute a virtual screening of flavonoids with antidepressant activity by using the database and an advanced chemoinformatic tool. In this section, we will briefly describe (1) flavonoid database and (2) virtual screening of antidepressant compounds.
Kinoshita
Takashi
T
Department of Molecular Analytical Chemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
Lepp
Zsolt
Z
Chuman
Hiroshi
H
D000928:Antidepressive Agents / Q000737:chemistry; D016208:Databases, Factual; D005419:Flavonoids / Q000737:chemistry*; D005502:Food; D008956:Models, Chemical; D013312:Stress, Physiological / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D000928:Antidepressive Agents; D005419:Flavonoids