title: Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.
abstract: A xanthone derivative, named gaboxanthone (1), has been isolated from the seed shells of Symphonia globulifera, together with known compounds, symphonin (2), globuliferin (3), guttiferone A (4), sistosterol, oleanolic acid and methyl citrate. The structure of the compound was assigned as 5,10-dihydroxy-8,9-dimethoxy-2,2-dimethyl-12-(3-methylbut-2-enyl) pyrano [3,2-b]xanthen-6(2H)-one, by means of spectroscopic analysis. The anti-plasmodial and antioxidant activities of the phenolic compounds were evaluated, respectively, in culture against W2 strain of Plasmodium falciparum and using the free radical scavenging activity of the DPPH radical, respectively. Compounds 1-4 were found to be active against the Plasmodium parasites (IC(50) of 3.53, 1.29, 3.86 and 3.17 microM, respectively). Guttiferone A (4) showed a potent free radical scavenging activity compared to the well-known antioxidant caffeic acid.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
authors.forename: Silvère
authors.initials: S
authors.lastname: Ngouela
authors.forename: Bruno Ndjakou
authors.initials: BN
authors.lastname: Lenta
authors.forename: Diderot Tchamo
authors.initials: DT
authors.lastname: Noungoue
authors.forename: Joseph
authors.initials: J
authors.lastname: Ngoupayo
authors.forename: Fabrice Fekam
authors.initials: FF
authors.lastname: Boyom
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
authors.forename: Jiri
authors.initials: J
authors.lastname: Gut
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenthal
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Connolly
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry* / Q000196:embryology; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification; D010963:Plasmodium falciparum / Q000187:drug effects; D012639:Seeds / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000975:Antioxidants; D044004:Xanthones; C508575:gaboxanthone; D009828:Oleanolic Acid