title: New World monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity.
abstract: Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.
authors.affiliation: Naval Medical Research Center, Biological Defense Research Directorate, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. jonesf@nmrc.navy.mil
authors.forename: Franca R
authors.initials: FR
authors.lastname: Jones
authors.forename: Shahida
authors.initials: S
authors.lastname: Baqar
authors.forename: Alfonso
authors.initials: A
authors.lastname: Gozalo
authors.forename: Gladys
authors.initials: G
authors.lastname: Nunez
authors.forename: Nereyda
authors.initials: N
authors.lastname: Espinoza
authors.forename: Sharina M
authors.initials: SM
authors.lastname: Reyes
authors.forename: Milagros
authors.initials: M
authors.lastname: Salazar
authors.forename: Rina
authors.initials: R
authors.lastname: Meza
authors.forename: Chad K
authors.initials: CK
authors.lastname: Porter
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Walz
mesh_terms: D000818:Animals; D016645:Aotidae; D002169:Campylobacter Infections / Q000276:immunology* / Q000517:prevention & control; D016123:Campylobacter jejuni / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D007117:Immunization, Secondary; D008297:Male