title: The small peptide-catalyzed direct asymmetric aldol reaction in water.
abstract: Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding beta-hydroxy ketones with up to 86% ee in water and 99% ee in aqueous media.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
authors.forename: Pawel
authors.initials: P
authors.lastname: Dziedzic
authors.forename: Weibiao
authors.initials: W
authors.lastname: Zou
authors.forename: Jonas
authors.initials: J
authors.lastname: Háfren
authors.forename: Armando
authors.initials: A
authors.lastname: Córdova
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D014867:Water
chemical_list: D000447:Aldehydes; D007659:Ketones; D009842:Oligopeptides; D014867:Water