title: Target motion measurement without implanted markers and its validation by comparison with manually obtained data.
abstract: For an effective radiotherapy the exact tumor location must be determined. The localization has to take into account patient's setup position as well as internal organ motion. Among the different localization methods, the use of a computer tomography (CT) scanner in the therapy room has been proposed recently. Achieving a CT with the patient on the therapy couch, a patient's treatment position is captured. We present a method to locate tumor considering internal organ motion and displacements due to respiration. We tested the method with prostate and lung patients. The method found the most probable tumor position as well as, for high-mobility tumors located in the lung, its trajectory during the respiratory cycle. The results of this novel method were validated by comparison with manually determined target position.
authors.affiliation: Klinik und Poliklinik für Strahlentherapie, Universität Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.
authors.forename: Lucia
authors.initials: L
authors.lastname: Vences
authors.forename: Jörn
authors.initials: J
authors.lastname: Wulf
authors.forename: Dirk
authors.initials: D
authors.lastname: Vordermark
authors.forename: Otto
authors.initials: O
authors.lastname: Sauer
authors.forename: Kajetan
authors.initials: K
authors.lastname: Berlinger
authors.forename: Michael
authors.initials: M
authors.lastname: Roth
mesh_terms: D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D009038:Motion; D009068:Movement; D009369:Neoplasms / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012119:Respiration; D012984:Software; D013382:Subtraction Technique; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*