title: Intrinsic bacterial contamination of a commercial iodophor solution: investigation of the implicated manufacturing plant.
abstract: After an outbreak of peritoneal infections attributed to intrinsic contamination of a poloxamer-iodine solution with Pseudomonas aeruginosa, the manufacturer of the contaminated solution permitted investigation and sampling of materials within the plant. Pseudomonas spp. were recovered from two different unopened lots of solution and from numerous water samples obtained at the plant. The isolates from water identical to those of an isolate recovered from Prepodyne solution (West-Agro Chemical Co., Inc., Westwood, Kans., manufactured for AMSCO Medical Products Div., Erie, Pa.) manufactured 1 month earlier at the same plant. P. aeruginosa was not recovered from incoming city water. P. aeruginosa was recovered from sterile water and poloxamer-iodine after 48 h of incubation in a plant polyvinyl chloride pipe. Scanning electron micrographs of polyvinyl chloride pipe used in the plant showed massive concentrations of rod-shaped and coccobacillary cells apparently embedded in interior deposits of the pipe. Manufacturers of iodophors should be aware that pipes or other surfaces colonized with bacteria may be a source of contamination of their products.
authors.affiliation: Hospital Infections Program, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
authors.forename: R L
authors.initials: RL
authors.lastname: Berkelman
authors.forename: R L
authors.initials: RL
authors.lastname: Anderson
authors.forename: B J
authors.initials: BJ
authors.lastname: Davis
authors.forename: A K
authors.initials: AK
authors.lastname: Highsmith
authors.forename: N J
authors.initials: NJ
authors.lastname: Petersen
authors.forename: W W
authors.initials: WW
authors.lastname: Bond
authors.forename: E H
authors.initials: EH
authors.lastname: Cook
authors.forename: D C
authors.initials: DC
authors.lastname: Mackel
authors.forename: M S
authors.initials: MS
authors.lastname: Favero
authors.forename: W J
authors.initials: WJ
authors.lastname: Martone