Regeneration of teeth using stem cell-based tissue engineering.
Tooth autotransplantation, allotransplantation and dental implants have existed for many years, but have never been totally satisfactory. Thus, the development of new methods of tooth replacement has become desirable, and with the increasing knowledge of stem cell biology becomes a realistic possibility. Stem cell-based tissue engineering involving the recapitulation of the embryonic environment demonstrates that dental, non-dental, embryonic and adult stem cells can contribute to teeth formation in the appropriate setting. Evidence that stem cell populations may be present in human teeth provides the opportunity to consider biological tooth replacement 'new for old'.
Yen
Amanda H-H
AH
Dental Institute, Department of Craniofacial Development, Odontis Ltd, Kings College London, Guy's Hospital, London Bridge, SE1 9RT, UK.
Sharpe
Paul T
PT
D000818:Animals; D006801:Humans; D008954:Models, Biological; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D023822:Tissue Engineering / Q000379:methods*; D014070:Tooth / Q000166:cytology / Q000502:physiology*; D014180:Transplantation / Q000379:methods