[Evaluation of the protective effect of magnesium on amikacin ototoxicity by electrophysiologic tests in guinea pigs].
OBJECTIVE
This experimental study was performed to evaluate the protective effect of magnesium on amikacin ototoxicity.


METHODS
Twenty-seven guinea pigs (54 ears) with normal auropalpebral reflexes and otomicroscopic examination, auditory brain stem responses (ABR), and transient evoked otoacoustic emissions (TEOAE) were randomly divided into four groups to receive amikacin once 15 mg/kg daily (group 1 and 3) and twice 7.5 mg/kg daily (group 2 and 4) for seven days. Groups 3 and 4 were administered oral MgCl an hour after amikacin use at a dose of 39 mmol/l and 19.5 mmol/l, respectively, for seven days. Otomicroscopic examination, ABR and TEOAE measurements were repeated on the third, fifth, and seventh days.


RESULTS
Compared to group 1, decreases in TEOAE amplitudes and reproducibility and increases in ABR thresholds were significant in group 2 (p<0.05). However, in groups 3 and 4, TEOAE amplitudes remained unchanged, or even increased and the reproducibility of TEOAE responses and ABR thresholds showed no significant changes (p>0.05).


CONCLUSIONS
Our data show that oral magnesium may play a protective role on amikacin ototoxicity.
Bulut
Erdoğan
E
Department of Otolaryngology, Medicine Faculty of Trakya University, Edirne, Turkey. erbulut2004@yahoo.com.
Yağiz
Recep
R
Taş
Abdullah
A
Uzun
Cem
C
Yildirim
Cetin
C
Kaymak
Kadir
K
Karasalioğlu
Ahmet R
AR
D000284:Administration, Oral; D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001309:Auditory Threshold / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced* / Q000517:prevention & control; D015636:Magnesium Chloride / Q000008:administration & dosage*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D020011:Protective Agents / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D020011:Protective Agents; D015636:Magnesium Chloride; D000583:Amikacin