title: New approaches to the genetic analysis of neuroticism and anxiety.
abstract: The completion of the human genome project and the complementary genome projects for other species has broadened the scope for novel bioinformatic approaches to quantitative trait locus (QTL) identification. A key issue for quantitative trait nucleotide (QTN) identification is progressing from a large QTL peak, spanning perhaps 50 cM and many hundreds of genes, to a gene or nucleotide variant which is responsible for that QTL effect. The complementary use of mouse models to dissect large syntenic loci in humans is a powerful method for reducing QTL intervals to the order of 1 Mb. This paper presents an overview of the approaches used in our laboratory to ultra-fine map QTLs for anxiety-related traits, and to identify quantitative trait genes (QTG). As new genetic techniques and statistical approaches arise, we are getting closer to identifying those long sought after QTNs.
authors.affiliation: The Wellcome Trust Centre for Human Genetics, The University of Oxford, Roosevelt Drive, OX37BN, UK. janf@well.ox.ac.uk
authors.forename: Jan
authors.initials: J
authors.lastname: Fullerton
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods; D005816:Genetic Complementation Test; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D023421:Models, Animal; D009497:Neurotic Disorders / Q000235:genetics*; D010551:Personality / Q000235:genetics*; D040641:Quantitative Trait Loci