Residues of gentamicin in eggs following medication of laying hens.
1. Gentamicin was injected subcutaneously and intramuscularly into 5 groups of 10 laying hens and its concentration was determined in albumen, yolk and whole egg. 2. Groups 1 and 3 were intramuscularly injected with doses of 10 and 25 mg/kg while groups 2, 4 and 5 were subcutaneously injected with doses of 10, 25 and 50 mg/kg, respectively. 3. The final gentamicin concentration in albumen was measured on d 3 for groups 1 and 2; on d 4 for groups 3 and 4, and on d 5 for group 5. Concentrations in yolk and whole egg were measured on d 7, 10 and 12. 4. Gentamicin recovery was as follows: 2% in groups 1 and 2, 2.5% in groups 3 and 4, and 3% in group 5. 5. Most of the residue (approximately 90%) was recovered from the yolk.
Filazi
A
A
Department of Pharmacology and Toxicology Faculty of Veterinary Medicine, University of Ankara, Diskapi, Turkey. filazi@veterinary.ankara.edu.tr
Sireli
U T
UT
Cadirci
O
O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D010063:Ovum / Q000737:chemistry*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins