title: Increased accumulations of N-isopropyl-p-[123I]-iodoamphetamine related to tumefactive multiple sclerosis.
abstract: We present a 21-year-old woman with tumefactive multiple sclerosis (MS) that exhibited a rapidly progressive course. There were multiple tumor-mimicking contrast-enhance lesions with surrounding edema and mass effect on magnetic resonance imaging. Both early and delayed brain single photon emission computed tomography (SPECT) with N-isopropyl-p-[123I]-iodoamphetamine demonstrated increased accumulations of the tracer and a high retention on the lesions. The SPECT findings represent a diagnostic pitfall for distinguishing MS from malignant brain tumors in patients with intracranial tumor-like lesions.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Kitamoto, Saitama, Japan. sagiuchi-t@kitasato.or.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Sagiuchi
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Oka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Utsuki
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Asano
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ishii
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujii
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control*; D005260:Female; D006801:Humans; D020367:Iofetamine / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging; D020528:Multiple Sclerosis, Chronic Progressive / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine