From angiogenesis to neuropathology.
Angiogenesis--the growth of new blood vessels--is a crucial force for shaping the nervous system and protecting it from disease. Recent advances have improved our understanding of how the brain and other tissues grow new blood vessels under normal and pathological conditions. Angiogenesis factors, especially vascular endothelial growth factor, are now known to have roles in the birth of new neurons (neurogenesis), the prevention or mitigation of neuronal injury (neuroprotection), and the pathogenesis of stroke, Alzheimer's disease and motor neuron disease. As our understanding of pathophysiology grows, these developments may point the way towards new molecular and cell-based therapies.
Greenberg
David A
DA
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA. dgreenberg@buckinstitute.org
Jin
Kunlin
K
D000818:Animals; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology; D006801:Humans; D051379:Mice; D009389:Neovascularization, Pathologic; D009420:Nervous System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A