title: Routine histopathologic analysis of product of conception following first-trimester spontaneous miscarriages.
abstract: OBJECTIVE
  To evaluate the histopathologic findings relating to tissue samples collected at surgical uterine evacuation in first-trimester spontaneous miscarriages.
  
  
  METHODS
  In this retrospective study, histopathologic diagnosis of the tissue samples obtained via surgical uterine evacuation in patients who were admitted to the Early Pregnancy Clinic in a 12-month period with the diagnosis of incomplete miscarriage (n = 970), missed miscarriage (n = 406) and anembryonic miscarriage (n = 230) in the first trimester was recorded and compared with the presurgery diagnosis.
  
  
  RESULTS
  Uterine evacuation was performed in cases of incomplete miscarriage (n = 970, 60.4%), missed miscarriage (n = 406, 25.2%) and anembryonic miscarriage (n = 230, 14.3%). Histopathologic examination revealed the product of conception in 1119 patients (69.7%), while partial hydatidiform mole was diagnosed in 33 patients (2.1%). Complete hydatidiform mole was detected in only seven cases (0.43%). Exaggerated placental site and placental site trophoblastic nodule was detected in two cases (0.12%). Decidual tissue without chorionic villi was reported in 272 patients (16.9%), raising the suspicion of presence of other pathology.
  
  
  CONCLUSIONS
  By routine histopathologic assessment of products of first-trimester spontaneous miscarriages, important pathologies such as molar pregnancy and placental trophoblastic disease can be diagnosed. Histopathological assessment has great value in the identification of an ectopic pregnancy or infection when compared with clinical and laboratory findings.
authors.affiliation: Department of Obstetrics and Gynecology, Ministry of Health Ankara Etlik Maternity and Women's Health Research Teaching Hospital, Ankara, Turkey. yytasci@yahoo.com
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tasci
authors.forename: Serdar
authors.initials: S
authors.lastname: Dilbaz
authors.forename: Ozlem
authors.initials: O
authors.lastname: Secilmis
authors.forename: Berna
authors.initials: B
authors.lastname: Dilbaz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozfuttu
authors.forename: Ali
authors.initials: A
authors.lastname: Haberal
mesh_terms: D000027:Abortion, Incomplete / Q000473:pathology; D000030:Abortion, Missed / Q000473:pathology; D000022:Abortion, Spontaneous / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D003656:Decidua / Q000473:pathology; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000473:pathology; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology; D008875:Middle Aged; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000473:pathology