Multimodal effects of available drugs for ischemic stroke.
Recent research demonstrates the complexity and variety of pathophysiologic processes underlying cerebral ischemia. This review will focus on the multimodal effects of the various drugs currently used for stroke prevention. The most recent clinical studies of each will also be reviewed, and the implications for clinical use and future research discussed. An evolving approach for stroke prevention will include a combination of antiplatelets, increased use of statins, ACE inhibitors and possibly vitamin therapy.
Chen
Michael
M
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. chenm888@yahoo.com.
Selim
Magdy
M
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy; D002544:Cerebral Infarction / Q000188:drug therapy; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D002546:Ischemic Attack, Transient / Q000188:drug therapy; D011619:Psychotropic Drugs / Q000627:therapeutic use; D020521:Stroke / Q000188:drug therapy
D000806:Angiotensin-Converting Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011619:Psychotropic Drugs