Sequence-encoded self-assembly of multiple-nanocomponent arrays by 2D DNA scaffolding.
Regular 2D arrays of multiple types of nanocomponents were constructed by self-assembly to DNA scaffolding with alternating rows of sequence-encoded hybridization sites. Different-sized Au particles coated with DNA complementary to one of the sites were bound to the scaffolding, producing alternating rows of the two nanocomponents with a 32-nm inter-row spacing. These results demonstrate the potential for using DNA to self-assemble complex arrays of components with nanometer-scale precision.
Pinto
Yariv Y
YY
Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Le
John D
JD
Seeman
Nadrian C
NC
Musier-Forsyth
Karin
K
Taton
T Andrew
TA
Kiehl
Richard A
RA
D001483:Base Sequence; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003460:Crystallization / Q000379:methods*; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D004867:Equipment Design; D017403:In Situ Hybridization / Q000295:instrumentation* / Q000379:methods; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation* / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods
D020099:Coated Materials, Biocompatible; D004247:DNA