title: Habituation of single CO2 laser-evoked responses during interictal phase of migraine.
abstract: A reduced habituation of averaged laser-evoked potential (LEP) amplitudes was previously found in migraine patients. The aim of the present study was to assess the habituation of single LEP responses and pain sensation during the interictal phase in migraine patients. Fourteen migraine patients were compared with ten control subjects. The pain stimulus was laser pulses, generated by CO2 laser, delivered to right supraorbital zone. Patients were evaluated during attack-free conditions. The LEP habituation was studied by measuring the changes of LEP amplitudes across and within three consecutive repetitions of 21 non-averaged trials. In migraine patients the N2-P2 wave amplitudes did not show a tendency toward habituation across and, above all, within the three repetitions. Anomalous behaviour of nociceptive cortex during the interictal phase of migraine may predispose patients to headache occurrence and persistence.
authors.affiliation: Clinica Neurologica, Policlinico, Piazza G. Cesare 11, I-70124, Bari, Italy. m.detommaso@neurol.niba.it
authors.forename: Marina
authors.initials: M
authors.lastname: de Tommaso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Libro
authors.forename: Marco
authors.initials: M
authors.lastname: Guido
authors.forename: Luciana
authors.initials: L
authors.lastname: Losito
authors.forename: Paolo
authors.initials: P
authors.lastname: Lamberti
authors.forename: Paolo
authors.initials: P
authors.lastname: Livrea
mesh_terms: D000328:Adult; D002245:Carbon Dioxide; D002540:Cerebral Cortex / Q000502:physiology; D015331:Cohort Studies; D005074:Evoked Potentials, Visual; D005260:Female; D006185:Habituation, Psychophysiologic; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*; D009619:Nociceptors / Q000502:physiology; D010775:Photic Stimulation
chemical_list: D002245:Carbon Dioxide