title: Idealhalers or realhalers? A comparison of Diskus and Turbuhaler.
abstract: Medication for the treatment of asthma and chronic obstructive pulmonary disease should be given locally by inhalation. There is, however, no such thing as an ideal inhaler, or 'Idealhaler', which has all desired properties with no drawbacks. In this short review, we have compared the relative merits of the two most commonly used dry powder inhalers -- Turbuhaler and Diskus. Clinical effect is related to the amount of inhaled drug that reaches the lungs, and this in turn depends on the amount of fine particles generated at inhalation. Turbuhaler is more than twice as effective as Diskus at generating fine particles, and the higher lung deposition with Turbuhaler is accompanied by a lower variability in lung deposition. Compared with Diskus, the lung deposition with Turbuhaler is affected less by factors such as humidity.
authors.affiliation: AstraZeneca R&D, Lund, Sweden. lars.borgstrom@astrazeneca.com
authors.forename: L
authors.initials: L
authors.lastname: Borgström
authors.forename: L
authors.initials: L
authors.lastname: Asking
authors.forename: L
authors.initials: L
authors.lastname: Thorsson
mesh_terms: D000280:Administration, Inhalation; D000730:Androstadienes / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide / Q000008:administration & dosage*; D000068298:Fluticasone; D006801:Humans; D009330:Nebulizers and Vaporizers / Q000592:standards*; D010316:Particle Size; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy
chemical_list: D000730:Androstadienes; D001993:Bronchodilator Agents; D019819:Budesonide; D000068298:Fluticasone