Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: an unusual presentation of an unusual neoplasm.
Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.
Milne
Anya N A
AN
Department of Pathology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands. a.n.milne@amc.uva.nl
Sweeney
Karl J
KJ
O'Riordain
Diarmuid S
DS
Pauwels
Patrick
P
Debiec-Rychter
Maria
M
Offerhaus
G Johan A
GJ
Jeffers
Michael
M
D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D003937:Diagnosis, Differential; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D007080:Ileocecal Valve / Q000473:pathology* / Q000601:surgery; D017404:In Situ Hybridization, Fluorescence; D007443:Intussusception / Q000175:diagnosis* / Q000201:enzymology / Q000601:surgery; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D011993:Recombinant Fusion Proteins; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases