title: Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall.
abstract: Ependymal cells appear to be totally differentiated during the first 3 weeks in the mouse brain. Early during postnatal development ependymal cells differentiate and undergo metabolic activation, which is accompanied by increased glucose uptake. We propose that ependymal cells induce an overexpression of the glucose transporter, GLUT1, during the first 2 weeks after delivery in order to maintain the early metabolic activation. During the first postnatal day, GLUT1 is strongly induced in the upper region of the third ventricle and in the ventral area of the rostral cerebral aqueduct. During the next 4 days, GLUT1 is expressed in all differentiated ependymal cells of the third ventricle and in hypothalamic tanycytes. At the end of the first week, ependymal cell differentiation and GLUT1 overexpression is concentrated in the latero-ventral area of the aqueduct. We propose that ependymal cell differentiation and GLUT1 overexpression is a synchronous process in the ventricular wall.
authors.affiliation: Departamento de Biología Celular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160C, Concepción, Chile.
authors.forename: Carmen
authors.initials: C
authors.lastname: Silva-Alvarez
authors.forename: Mónica
authors.initials: M
authors.lastname: Carrasco
authors.forename: Carolina
authors.initials: C
authors.lastname: Balmaceda-Aguilera
authors.forename: Patricia
authors.initials: P
authors.lastname: Pastor
authors.forename: María de los Angeles
authors.initials: Mde L
authors.lastname: García
authors.forename: Karin
authors.initials: K
authors.lastname: Reinicke
authors.forename: Luis
authors.initials: L
authors.lastname: Aguayo
authors.forename: Benedicto
authors.initials: B
authors.lastname: Molina
authors.forename: Manuel
authors.initials: M
authors.lastname: Cifuentes
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Medina
authors.forename: Francisco
authors.initials: F
authors.lastname: Nualart
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D002552:Cerebral Ventricles / Q000033:anatomy & histology* / Q000254:growth & development / Q000378:metabolism; D004805:Ependyma / Q000166:cytology*; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D051272:Glucose Transporter Type 1; C495678:Slc2a1 protein, mouse