PIDD: a switch hitter.
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.
Wu
Zhao-Hui
ZH
Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.
Mabb
Angela
A
Miyamoto
Shigeki
S
D017209:Apoptosis / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology*; D053418:Death Domain Receptor Signaling Adaptor Proteins; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D025842:SUMO-1 Protein / Q000378:metabolism; D015398:Signal Transduction
D002352:Carrier Proteins; D053418:Death Domain Receptor Signaling Adaptor Proteins; C491731:IKBKG protein, human; D016328:NF-kappa B; C485896:PIDD1 protein, human; D025842:SUMO-1 Protein; D051550:I-kappa B Kinase