title: A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families.
abstract: Many twin studies have identified sex differences in the influence of genetic and environmental factors on smoking behaviors. We explore the evidence for sex differences for smoking initiation and cigarette consumption in a sample of Australian twin families, and extend these models to incorporate sex differences in linkage analyses for these traits. We further examine the impact of including or excluding non-smokers in genetic analyses of tobacco consumption. Accounting for sex differences improved linkage results in some instances. We identified one region suggestive of linkage on chromosome 11p12. This locus, as well as another region identified on chromosome 6p12, replicates regions identified in previous studies.
authors.affiliation: Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia. kateM@qimr.edu.au
authors.forename: Katherine I
authors.initials: KI
authors.lastname: Morley
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Medland
authors.forename: Manuel Ar
authors.initials: MA
authors.lastname: Ferreira
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lynskey
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Heath
authors.forename: Pamela Af
authors.initials: PA
authors.lastname: Madden
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011793:Queensland; D012907:Smoking / Q000235:genetics*; D011795:Surveys and Questionnaires; D014029:Tobacco Use Disorder / Q000235:genetics; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic