title: Cefuroxime axetil solid dispersions prepared using solution enhanced dispersion by supercritical fluids.
abstract: Cefuroxime axetil (CA) solid dispersions with HPMC 2910/PVP K-30 were prepared using solution enhanced dispersion by supercritical fluids (SEDS) in an effort to increase the dissolution rate of poorly water-soluble drugs. Their physicochemical properties in solid state were characterized by differential scanning calorimeter (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectrometry (FT-IR) and scanning electron microscopy. No endothermic and characteristic diffraction peaks corresponding to CA were observed for the solid dispersions in DSC and PXRD. FTIR analysis demonstrated the presence of intermolecular hydrogen bonds between CA and HPMC 2910/PVP K-30 in solid dispersions, resulting in the formation of amorphous or non-crystalline CA. Dissolution studies indicated that the dissolution rates were remarkably increased in solid dispersions compared with those in the physical mixture and drug alone. In conclusion, an amorphous or non-crystalline CA solid dispersion prepared using SEDS could be very useful for the formulation of solid dosage forms.
authors.affiliation: National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Korea.
authors.forename: Seoung Wook
authors.initials: SW
authors.lastname: Jun
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Guk Hyun
authors.initials: GH
authors.lastname: Jo
authors.forename: Sibeum
authors.initials: S
authors.lastname: Lee
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Woo
authors.forename: Jeong-Sook
authors.initials: JS
authors.lastname: Park
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Hwang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000737:chemistry; D025924:Chromatography, Supercritical Fluid; D006860:Hydrogen Bonding; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime; C040738:cefuroxime axetil