Assessment of dynamic susceptibility contrast cerebral blood flow response to amphetamine challenge: a human pharmacological magnetic resonance imaging study at 1.5 and 4 T.
Pharmacological MRI (phMRI) techniques can be used to monitor the neurophysiological effects of central nervous system (CNS) active drugs. In this study, we investigated whether dynamic susceptibility contrast (DSC) perfusion imaging employing the use of superparamagnetic iron oxide nanoparticles (Resovist) could be used to measure hemodynamic response to d-amphetamine challenge in human subjects at both 1.5 and 4 T. Significant changes in cerebral blood flow (CBF) were found in focal regions associated with the nigrostriatal circuit and mesolimbic and mesocortical dopaminergic pathways. More significant CBF responses were found at higher field strength, mainly within striatal structures. The results from this study indicate that DSC perfusion imaging using Resovist can be used to assess the efficacy of CNS-active drugs and may play a role in the development of novel psychiatric therapies at the preclinical level.
Rose
Stephen E
SE
Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia. Stephen.Rose@cmr.uq.edu.au
Janke
Andrew L
AL
Strudwick
Mark W
MW
McMahon
Katie L
KL
Chalk
Jonathan B
JB
Snyder
Peter
P
De zubicaray
Greig I
GI
D000328:Adult; D000661:Amphetamine / Q000493:pharmacokinetics*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D010087:Oxides
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D000661:Amphetamine; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide