title: Comparative genomic hybridization analysis on male breast cancer.
abstract: The spectrum of genetic alterations in primary male breast cancer is not well established. We analyzed chromosomal imbalances in 39 tumor samples from primary male breast cancer by comparative genomic hybridization (CGH) and correlated CGH findings with clinicopathological factors. Chromosomal gains were most frequent at 1q (46%), 8q (46%), 16p (36%), 17q (36%), Xq (28%), 20q (26%) and Xp (18%). Losses were most commonly observed at 8p (36%), 16q (28%), 13q (28%), 6q (18%), 11q (18%) and 22q (18%). Gains at 16p, 20q and Xq and losses at 13q correlated significantly with higher degree of cytogenetic complexity. Significant associations with clinicopathological factors were observed for +8q and -16q with larger tumor size and -16q with lower proliferative activity and lower grade of malignancy. A comparison with reported CGH data from female breast cancer showed a similar pattern of chromosomal imbalances, including +1q, -8p, +8q, -13q, +16p, -16q, +17q and +20q. Our results indicate that male breast cancer shares a common pattern of imbalances with female breast cancer, suggesting that similar genetic events may underlie the development and progression of male and female breast cancer.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bonn, Germany. rudlowski@t-online.de
authors.forename: Christian
authors.initials: C
authors.lastname: Rudlowski
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Schulten
authors.forename: Mariola Monika
authors.initials: MM
authors.lastname: Golas
authors.forename: Bjoern
authors.initials: B
authors.lastname: Sander
authors.forename: Roland
authors.initials: R
authors.lastname: Barwing
authors.forename: Jens-Ekkehard
authors.initials: JE
authors.lastname: Palandt
authors.forename: Bettina
authors.initials: B
authors.lastname: Schlehe
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lindenfelser
authors.forename: Roland
authors.initials: R
authors.lastname: Moll
authors.forename: Torsten
authors.initials: T
authors.lastname: Liersch
authors.forename: Volker
authors.initials: V
authors.lastname: Schumpelick
authors.forename: Bastian
authors.initials: B
authors.lastname: Gunawan
authors.forename: László
authors.initials: L
authors.lastname: Füzesi
mesh_terms: D000328:Adult; D018567:Breast Neoplasms, Male / Q000235:genetics*; D002869:Chromosome Aberrations; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009693:Nucleic Acid Hybridization