[Malignant neuroleptic syndrome and polyserositis associated to clozapine use: report of one case].
Malignant neuroleptic syndrome is a complication of antipsychotic medication use. Clozapine use is also associated with polyserositis and eosinophilia. We report a 17 years old female treated with clozapine, valproic acid, lithium carbonate and lorazepam that consulted in the emergency room for confusion, lethargy, catatonia, rigidity, myalgya and fever. Complete blood count showed eosinophilia. An abdominal CAT scan showed ascites and pleural effusion. Clozapine was discontinued and bromocriptine was started. One week after admission, the patient remained febrile and liver enzymes were elevated. Valproic acid was discontinued. Inflammatory parameters stated to subside and the patient was discharged afebrile days after admission.
Eymin
Gonzalo
G
Departamento de Medicina Interna, Hospital Clínico de la Pontificia Universidad Católica de Chile. eyminlago@yahoo.com
Andresen
Max
M
Godoy
Jaime
J
Rada
Gabriel
G
D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D003024:Clozapine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*
D014150:Antipsychotic Agents; D003024:Clozapine