The aging myocardium: roles of mitochondrial damage and lysosomal degradation.
Myocardial aging, leading to circulatory dysfunction, complicates numerous pathologies and is an important contributor to overall mortality at old age. In cardiac myocytes, mitochondria and lysosomes suffer remarkable age-related alterations. Mitochondrial changes include structural disorganization and enlargement, while lysosomes, which are responsible for autophagic turnover of mitochondria, accumulate lipofuscin (age pigment), a polymeric, autofluorescent, undegradable material. These changes are caused by continuous physiological oxidative stress, and they advance with age because the cellular turnover machinery is inherently imperfect. Several mechanisms contribute to age-related accumulation of damaged mitochondria following initial oxidative injury. Such mechanisms may include clonal expansion of defective mitochondria, decreased propensity of altered mitochondria to become autophagocytosed (due to mitochondrial enlargement or decreased membrane damage associated with weakened respiration), suppressed autophagy because of heavy lipofuscin loading of lysosomes, and decreased efficiency of Lon and AAA proteases. Because lipofuscin-laden lysosomes still receive newly synthesized lysosomal enzymes, even though they fail to degrade the pigment, the cells become in short supply of lysosomal hydrolases for functional autophagy, further limiting mitochondrial turnover. This interrelated mitochondrial and lysosomal damage eventually results in functional failure and death of cardiac myocytes.
Terman
Alexei
A
Division of Pathology II, Faculty of Health Sciences, Linköping University, University Hospital, SE-58185 Linköping, Sweden. alex.terman@inr.liu.se
Brunk
Ulf T
UT
D000375:Aging / Q000502:physiology*; D001343:Autophagy / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000473:pathology* / Q000502:physiology; D032342:Muscle Cells / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology
D008062:Lipofuscin