title: Fish drug analysis--Phish-Pharm: a searchable database of pharmacokinetics data in fish.
abstract: Information about drug residues and pharmacokinetic parameters in aquatic species is relatively sparse. In addition, it is difficult to rapidly compare data between studies due to differences in experimental conditions, such as water temperatures and salinity. To facilitate the study of aquatic species drug metabolism, we constructed a Fish Drug/Chemical Analysis Phish-Pharm (FDA-PP) database. This database consists of more than 400 articles that include data from 90 species (64 genera) of fish. Data fields include genus, species, water temperatures, the average animal weight, sample types analyzed, drug (or chemical) name, dosage, route of administration, metabolites identified, method of analysis, protein binding, clearance, volume of distribution in a central compartment (Vc) or volume of distribution at steady-state (Vd), and drug half-lives (t((1/2))). Additional fields list the citation, authors, title, and Internet links. The document will be periodically updated, and users are invited to submit additional data. Updates will be announced in future issues of The AAPS Journal. This database will be a valuable resource to investigators of drug metabolism in aquatic species as well as government and private organizations involved in the drug approval process for aquatic species.
authors.affiliation: Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA. renate.reimschuessel@fda.hhs.gov
authors.forename: Renate
authors.initials: R
authors.lastname: Reimschuessel
authors.forename: Leslie
authors.initials: L
authors.lastname: Stewart
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Squibb
authors.forename: Keiko
authors.initials: K
authors.lastname: Hirokawa
authors.forename: Tiffany
authors.initials: T
authors.lastname: Brady
authors.forename: Deborah
authors.initials: D
authors.lastname: Brooks
authors.forename: Badar
authors.initials: B
authors.lastname: Shaikh
authors.forename: Clifford
authors.initials: C
authors.lastname: Hodsdon
mesh_terms: D000818:Animals; D016208:Databases, Factual / Q000706:statistics & numerical data*; D005399:Fishes / Q000378:metabolism*; D014018:Tissue Distribution / Q000187:drug effects / Q000502:physiology; D019155:Veterinary Drugs / Q000032:analysis* / Q000493:pharmacokinetics*
chemical_list: D019155:Veterinary Drugs