title: Correlation of central venous and arterial blood gas measurements in mechanically ventilated trauma patients.
abstract: OBJECTIVE
  Central venous blood gas (VBG) measurements of pH, PCO2, and base excess can be substituted for the same values obtained from an arterial blood gas (ABG) analysis in mechanically ventilated trauma patients, obviating the need for arterial puncture.
  
  
  METHODS
  Prospective comparison of 99 sets of VBGs and ABGs at a level 1 academic trauma center.
  
  
  METHODS
  A consecutive sample of 25 trauma patients admitted to the intensive care unit who required mechanical ventilation and had both central venous and arterial catheters.
  
  
  METHODS
  Pearson correlations and Bland-Altman limits of agreement (LOAs) for pH, PCO2, and base excess values from each set of VBGs and ABGs.
  
  
  RESULTS
  When VBG and ABG values were compared, pH had R = 0.92, P<.001, and 95% LOAs of -0.09 to 0.03; PCO2, R = 0.88, P<.001, and 95% LOAs of -2.2 to 10.9; and base excess, R = 0.96, P<.001, and 95% LOAs of -2.2 to 1.8. A receiver operating characteristic curve showed that a central venous PCO2 of 50 mm Hg had 100% sensitivity and 84% specificity for determining significant hypercarbia (arterial PCO2 > 50 mm Hg).
  
  
  CONCLUSIONS
  Central venous and arterial PCO2, pH, and base excess values correlate well, but their LOAs represent clinically significant ranges that could affect management. Although VBGs cannot be substituted for ABGs in mechanically ventilated trauma patients during the initial phases of resuscitation, clinically reliable conclusions can be reached with VBG analysis.
authors.affiliation: Department of Surgery, Oregon Health and Science University, Portland, USA. dmalinoski@hotmail.com
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Malinoski
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Todd
authors.forename: Sue
authors.initials: S
authors.lastname: Slone
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Mullins
authors.forename: Martin A
authors.initials: MA
authors.lastname: Schreiber
mesh_terms: D001784:Blood Gas Analysis / Q000379:methods*; D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008991:Monitoring, Physiologic; D011446:Prospective Studies; D012372:ROC Curve; D012121:Respiration, Artificial; D014947:Wounds and Injuries / Q000097:blood*
chemical_list: D002245:Carbon Dioxide