title: Class 1 integrons in Enterobacteriaceae isolated from clinical infections of horses and dogs in the Netherlands.
abstract: Integrons in gentamicin- and cotrimoxazole-resistant Enterobacteriaceae from dogs and horses with clinical infections were analyzed by conserved segment PCR-RFLP. Five distinct integron types were found, most of which have previously been reported in Enterobacteriaceae isolated from humans and farm animals, indicating that resistance genes are exchanged between the reservoirs in humans, farm animals, and companion animals.
authors.affiliation: Veterinary Microbiological Diagnostic Center, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. E.duijkeren@vet.uu.nl
authors.forename: Engeline Van
authors.initials: EV
authors.lastname: Duijkeren
authors.forename: Adrienne T A
authors.initials: AT
authors.lastname: Box
authors.forename: Pepijn
authors.initials: P
authors.lastname: Schellen
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Houwers
authors.forename: Ad C
authors.initials: AC
authors.lastname: Fluit
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses; D032023:Integrons; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009426:Netherlands; D010641:Phenotype; D016133:Polymerase Chain Reaction; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination