The neuronal histamine H(1) and pro-opiomelanocortin-melanocortin 4 receptors: independent regulation of food intake and energy expenditure.
Hypothalamic neuronal histamine and its H(1) receptor (H(1)-R) form part of the leptin signaling pathway in the brain, and regulate body weight and adiposity by affecting food intake and energy expenditure. The pro-opiomelanocortin (POMC)-melanocortin 4 receptor (MC4-R) is also important for leptin signaling. We investigated whether and how these two neuronal pathways interact in regulating energy metabolism. From studies of agouti yellow (A(y)/a) obese mice, a model of a defect in POMC-MC4-R signaling, we concluded that the histamine H(1)-R signaling pathway is independent of the POMC-MC4-R complex in regulating food intake, energy metabolism, and adiposity.
Yoshimatsu
Hironobu
H
Department of Internal Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Oita 879-5593, Japan. hiroy@oita-med.ac.jp
D000818:Animals; D001069:Appetite Regulation / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005247:Feeding Behavior; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology; D020738:Leptin / Q000502:physiology; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D009765:Obesity; D011333:Pro-Opiomelanocortin / Q000378:metabolism*; D051381:Rats; D044105:Receptor, Melanocortin, Type 4 / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*
D020738:Leptin; D044105:Receptor, Melanocortin, Type 4; D011969:Receptors, Histamine H1; D011333:Pro-Opiomelanocortin; D006632:Histamine; D009074:Melanocyte-Stimulating Hormones