title: [Prognostic significance of depth and mode of invasion of the neoplasm in the presence of micrometastases in laryngeal carcinoma--cytokeratin antigens expression in lymph nodes].
abstract: According to the recent reports analyses of characteristic of neoplasm's invasion is one of the most reliable methods of estimation the progress of the changes of tumor and prediction the outcome in patients with laryngeal cancer. Depth and mode of invasion are features which are able to assess the dynamics of the tumor growth quite precisely. In this study it was presented direct relation between morphological features of tumor front as a depth and mode of carcinoma's growth and the probability of micrometastases. The authors have analysed 22 cases of patients who were operated on the laryngeal squamous cell carcinoma in ENT Department Medical University of Lodz in the period of 1998-1999. Features of the TFG and its dependence on lymph node micrometastases, considered in immunohistochemistry with using of panel of cytokeratins (CKs) were analysed. Our study showed that feature such as depth and mode of invasion is very useful in prediction of micrometastases in patients with laryngeal squamous cell carcinoma.
authors.affiliation: Katedra Otolaryngologii, Klinika Laryngologii i Onkologii Laryngologicznej, Uniwersytet Medyczny, Lodzi.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Starska
authors.forename: Marek
authors.initials: M
authors.lastname: Lukomski
authors.forename: Iwona
authors.initials: I
authors.lastname: Lewy-Trenda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000276:immunology*; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism*; D008207:Lymphatic Metastasis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000951:Antigens, Neoplasm; D007633:Keratins