title: Effects of soluble TNF receptor II (sTNF-RII), IL-1 receptor antagonist (IL-1ra), tumor load and hypermetabolism on malnutrition in children with acute leukemia.
abstract: OBJECTIVE
  Soluble tumor necrosis factor receptor II (sTNF-RII) and interleukin-1 receptor antagonist (IL-1ra) might modulate nutritional status in acute leukemia since they are inhibitors of tumor necrosis factor-alpha and interleukin-1 that can induce tissue wasting. On the other hand, tumor load and hypermetabolism may induce malnutrition. We determined whether serum levels of sTNF-RII and IL-1ra are upregulated to prevent overt malnutrition and whether tumor load and hypermetabolism induce overt malnutrition.
  
  
  METHODS
  We examined 31 children with newly diagnosed acute leukemia and correlated sTNF-RII, IL-1ra, tumor load and energy expenditure to anthropometric characteristics (weight, weight for height, height, body mass index, fat free mass) and serum protein concentrations (albumin, transferrin, prealbumin). As controls, 68 healthy children were examined for anthropometric characteristics; 33 healthy controls were included for cytokine analysis and biochemical indices.
  
  
  RESULTS
  We found no correlations between sTNF-RII, IL-1ra, tumor load and energy expenditure and anthropometric characteristics or protein concentrations. Mean sTNF-RII level was significantly, mean IL-1ra level slightly increased (223% and 113% of the controls). 29% of the children had a high tumor load (> 100.000/microl white blood cells) and 53% had hypermetabolism (resting energy expenditure > 110% of predicted). Anthropometric characteristics were similar to those in controls, however, serum protein concentrations were decreased.
  
  
  CONCLUSIONS
  sTNF-RII and IL-1ra are upregulated in children with leukemia and may therefore prevent overt malnutrition. Tumor load and hypermetabolism do not induce overt malnutrition. The children presented with an early stage of malnutrition as evidenced by low serum protein concentrations but normal anthropometric characteristics.
authors.affiliation: Kinderklinik and Kinderpoliklinik im Dr. von Haunerschen Kinderspital, University of Munich, Lindwurmstrasse 4, D-80337 Munich, Germany. Irene.Schmid@med.uni-muenchen.de
authors.forename: I
authors.initials: I
authors.lastname: Schmid
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: M
authors.initials: M
authors.lastname: Streiter
authors.forename: R
authors.initials: R
authors.lastname: Meilbeck
authors.forename: R J
authors.initials: RJ
authors.lastname: Haas
authors.forename: D K
authors.initials: DK
authors.lastname: Stachel
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000886:Anthropometry; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007223:Infant; D053590:Interleukin 1 Receptor Antagonist Protein; D007938:Leukemia / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D044342:Malnutrition / Q000378:metabolism*; D011228:Prealbumin / Q000032:analysis; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis; D012795:Sialoglycoproteins / Q000097:blood*; D012995:Solubility; D014168:Transferrin / Q000032:analysis; D047368:Tumor Burden
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D011228:Prealbumin; D047889:Receptors, Tumor Necrosis Factor, Type II; D012709:Serum Albumin; D012795:Sialoglycoproteins; D014168:Transferrin