Quantifying regional right ventricular function in tetralogy of Fallot.
Right ventricular (RV) function is notoriously difficult to quantify. Patients with tetralogy of Fallot (TOF) have decreased systolic performance. We measure regional RV performance using MRI with 1-dimensional myocardial tissue tagging. By tagging cine-MRI in two views, we measured regional shortening in 12 regions throughout the RV. We image 32 pediatric patients: 21 normal patients and 11 patients with repaired TOF. We establish a normal range for each RV region. TOF patients have decreased shortening on a region-by-region basis. We conclude that regional RV performance can be measured using this technique, and that decreased performance can be demonstrated in TOF patients.
Menteer
Jondavid
J
Division of Cardiology, Children's Hospital Los Angeles, MS #34, 4650 Sunset Blvd., Los Angeles, CA 90027, USA. jmenteer@chla.usc.edu
Weinberg
Paul M
PM
Fogel
Mark A
MA
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D006348:Cardiac Surgical Procedures; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015986:Confounding Factors, Epidemiologic; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009200:Myocardial Contraction; D011665:Pulmonary Valve Insufficiency / Q000503:physiopathology; D013318:Stroke Volume; D013771:Tetralogy of Fallot / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D016278:Ventricular Function, Right