title: Effect of monocyte chemoattractant protein-1 and estradiol on the secretion of vascular endothelial growth factor in endometrial stromal cells in vitro.
abstract: To explore the initial activity of endometrial stromal cells (ESCs) and the participation of monocyte chemoattractant protein-1 (MCP-1) in the histogenesis of endometriosis, vascular endothelial growth factor (VEGF) secretion of ESCs and the effect of MCP-1 on VEGF secretion of ESCs were observed in vitro. The VEGF level was detected in ESC culture media and was increased significantly when E2 or MCP-1 was added to the media, especially in the presence of E2 plus MCP-1. The VEGF secretion was higher in the ESCs of women with endometriosis than in those women without endometriosis.
authors.affiliation: Department of Gynecology, Obstetrics and Gynecology Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
authors.forename: Jinfang
authors.initials: J
authors.lastname: Lin
authors.forename: Yu
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000494:pharmacology*; D004357:Drug Synergism; D004715:Endometriosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000166:cytology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D042461:Vascular Endothelial Growth Factor A; D004958:Estradiol