title: [Characteristics of cosmonauts' metabolism after extended missions on the international space station].
abstract: In eight Russian members of the ISS crews 1 to 5 enzymes and some other metabolites were analyzed in blood in the pre- launch period, on the landing day, and on days 6-8 and 14-19 of recovery. Deviations in the biochemical parameters were typically within the physiological norm without clinical implications. Biochemical deviations on the landing day seemed to relate to metabolic shifts due to long-term microgravity and, on the other hand, were a reaction to acute gravitational stress on return to 1 g. Dynamics of a number of parameters was markedly different as compared with the data from cosmonauts who had made long missions to the Mir space station, but this can be attributed to different g-profiles during descent and blood sampling schedule. In two to three wks the parameters regained normal values suggesting that negative effects of readaptation to the Earth's gravity were fully remedied.
authors.forename: A A
authors.initials: AA
authors.lastname: Markin
authors.forename: O A
authors.initials: OA
authors.lastname: Zhuravleva
authors.forename: B V
authors.initials: BV
authors.lastname: Morukov
authors.forename: L V
authors.initials: LV
authors.lastname: Vostrikova
authors.forename: I V
authors.initials: IV
authors.lastname: Zabolotskaia
authors.forename: V P
authors.initials: VP
authors.lastname: Poluĕktova
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000337:Aerospace Medicine; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D018480:Astronauts; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D007391:International Cooperation; D013026:Space Flight; D018531:Spacecraft; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase