title: [Effect of changji' an oral liquid on activated signal alterative intensity in algesthesia domain in patients with diarrhea type irritable bowel syndrome due to gan-pi disharmony].
abstract: OBJECTIVE
  To observe the effect of Changji' an (CJA) oral liquid on the activated signal alterative intensity (ASAI) in intracranial algesthesia domain in patients with diarrhea type irritable bowel syndrome (IBS) due to Gan-Pi disharmony.
  
  
  METHODS
  Twenty-four patients were randomly divided into 2 groups, 14 in the treated group and 10 in the control group, they were administrated with CJA and placebo respectively. The sensory threshold and score in the two groups recorded by rectal inflation test were compared and analyzed. The change of ASAI in intracranial algesthesia domain was analyzed by functional magnetic resonance imagine (fM-RI) during rectum being inflated with 30 ml, 60 ml, 90 ml and 120 ml of gas respectively.
  
  
  RESULTS
  The initial sensory thresholds in the two groups were insignificantly different, but significant difference did show between the two groups in urgent defecation threshold and pain threshold after treatment (P < 0.05). Comparison in visual simulative scores between the two groups after treatment at rectal inflated for 30 ml showed no significant difference, but it showed significant difference when the inflation was over 30 ml (P < 0.05). In the treated group, the ASAI in insula cortex when rectal inflation being 90 ml or 120 ml and that in thalamus when rectal inflation being 120 ml were significantly decreased (P < 0.05). But in the control group, it changed insignificantly after treatment.
  
  
  CONCLUSIONS
  The treatment of CJA on Gan-Pi disharmony caused diarrhea type IBS might be effected by regulating the ASAI in intracranial insula cortex and thalamus.
authors.affiliation: Department of Gastroenterology, Ruijin Hospital, Shanghai, Second Medical University Shanghai.
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhu
authors.forename: Yao-zong
authors.initials: YZ
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D017288:Pain Threshold / Q000187:drug effects; D008517:Phytotherapy; D012684:Sensory Thresholds / Q000187:drug effects*; D015398:Signal Transduction
chemical_list: D004365:Drugs, Chinese Herbal