Addition of a chiral copper reagent derived from propargylic oxazolidininone to aldehydes.
[reaction: see text] The copper reagent arising from an optically pure propargylic oxazolidinone was found to react regio- and diastereoselectively with aldehydes, leading, in a one-pot procedure, to the anti homopropargylic amino alcohols derivatives in good yields.
Alouane
Nacira
N
Laboratoire de Chimie Organique, UMR 761, Institut de Chimie Moléculaire FR 2769, Université Pierre et Marie Curie, 75252 Paris Cedex 05, France.
Bernaud
Frederic
F
Marrot
Jerôme
J
Vrancken
Emmanuel
E
Mangeney
Pierre
P