[Age- and sex-related differences in sensitivity to hepatotoxic action of estragole in mice].
As determined by blood activity of alanine- and aspartate aminotransferases, intraperitoneal injection of estragole in subcarcinogenic dose 300 mg/kg does not damage the liver of suckling off-spring of both sexes and of adult SWR/J males but drastically damages it in mature females of this strain. Castration only slightly decreases the resistance of males to hepatotoxic action of estragole but significantly increases it in females; exogenous administration of estradiole benzoate to castrated males decreases their resistance to the hepatotoxin, whereas administration of testosterone propionate to ovariectomyzed females does not elevate it. Morphologically, estragole damages the same number of liver cells in females and males, but in males it induces mostly hydropic degenerative, and in females--necrotic changes of hepatocytes.
Vasil'ev
E D
ED
Il'nitskaia
S I
SI
Nikitenko
E V
EV
Kaledin
V I
VI
D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000819:agonists / Q000037:antagonists & inhibitors / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D022781:Hepatocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D013739:Testosterone; D004958:Estradiol; C007633:estragole; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase