[Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus].
BACKGROUND
Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer.


OBJECTIVE
To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus.


METHODS
Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus.


RESULTS
Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57).


CONCLUSIONS
Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr.
Corvalán
Alejandro
A
Departamento de Anatomía Patológica, Pontificia Universidad Católica de Chile, Santiago, Chile. corvalan@med.puc.cl
Akiba
Suminori
S
Valenzuela
María Teresa
MT
Cumsille
Miguel Angel
MA
Koriyama
Chihaya
C
Argandoña
Jorge
J
Backhouse
Claudia
C
Bal
Matilde
M
Mena
Fernando
F
Palma
Mariana
M
Eizuru
Yoshito
Y
D000328:Adult; D000368:Aged; D002299:Cardia / Q000473:pathology / Q000821:virology*; D016009:Chi-Square Distribution; D002677:Chile / Q000453:epidemiology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000401:mortality / Q000473:pathology; D005260:Female; D016158:Genes, p53; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000821:virology*