title: Impaired ambulatory venous function in lymphedema assessed by near-infrared spectroscopy.
abstract: OBJECTIVE
  The aim of this study was to investigate venous function in patients with leg lymphedema during exercise using near-infrared spectroscopy (NIRS), compared with that of patients with chronic venous insufficiency (CVI).
  
  
  METHODS
  Forty-three legs of 33 patients (5 males, 28 females; mean age: 53 years) with leg lymphedema without varicose veins or deep vein thrombosis underwent a treadmill walking test with simultaneous NIRS. For comparison, 136 legs of 91 patients (35 males, 56 females; mean age: 56 years) with varicose veins as a CVI group and 45 legs of 38 healthy volunteers (23 males, 15 females; mean age: 50 years) were also evaluated in the same method. Deoxygenated hemoglobin (HHb) was continuously measured during exercise, and the ambulatory venous retention index (AVRI) of each leg was obtained from the serial changes in HHb.
  
  
  RESULTS
  The mean AVRI of the lymphedema group was significantly higher than that of healthy legs and significantly lower than of legs with moderate or severe CVI. Furthermore, it was similar to that in the mild CVI group.
  
  
  CONCLUSIONS
  Venous function is impaired in exercising legs with lymphedema, and corresponds to that in legs with mild venous insufficiency. The treatment of lymphedema should take CVI into consideration.
authors.affiliation: Division of Vascular Surgery, Department of Surgery, The University of Tokyo, Hongo, Tokyo, Japan. taketo@sage.ocn.ne.jp
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Hosoi
authors.forename: A
authors.initials: A
authors.lastname: Onozuka
authors.forename: T
authors.initials: T
authors.lastname: Komiyama
authors.forename: T
authors.initials: T
authors.lastname: Miyata
authors.forename: H
authors.initials: H
authors.lastname: Shigematsu
authors.forename: H
authors.initials: H
authors.lastname: Nagawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006801:Humans; D008209:Lymphedema / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D019265:Spectroscopy, Near-Infrared; D014689:Venous Insufficiency / Q000097:blood* / Q000209:etiology / Q000503:physiopathology
chemical_list: D006451:Hemoglobin, Sickle