Artificial ribonucleases.
Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists. During the past decade, mimics for RNA-cleaving enzymes, ribonucleases, or, more precisely, mimics of ribozymes that cleave RNA in sequence-selective rather than base-selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides (or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.
Niittymäki
Teija
T
Department of Chemistry, University of Turku, FIN-20014, Turku, Finland.
Lönnberg
Harri
H
D002384:Catalysis; D008670:Metals; D018716:Molecular Mimicry; D009841:Oligonucleotides / Q000138:chemical synthesis; D015202:Protein Engineering / Q000379:methods*; D012260:Ribonucleases / Q000138:chemical synthesis*; D013379:Substrate Specificity
D008670:Metals; D009841:Oligonucleotides; D012260:Ribonucleases