title: Cystatin C as a marker for detection of early renal failure in diabetes type 2 patients.
abstract: The epidemiological studies have show dramatic increase and prevalence of end stage renal disease in patients with type 2 diabetes therefore early markers of diabetic nephropathy need to be identified (1). During the treatment of patients at the Clinic of endocrinology, diabetes mellitus and metabolic diseases in Sarajevo, we observed a necessity of application of new markers in assessment of early renal failure. Serum cystatin C level is another marker of renal function. Cystatin C is freely filtered at the level of the glomerulus and virtually all is re-absorbed and metabolized by the proximal tubular cells. Serum cystatin C is a screening test and an early indicator and predictor of the development of renal failure.
  
  
  OBJECTIVE
  To estimate correlation among cystatin C, serum creatinine and albuminuria in diabetes type 2 patients for assessment of early renal failure. Serum cystatin C as a screening test has to be considered in the treatment of diabetes type 2 patients for assessment of early renal failure.
authors.affiliation: Clinic of Endocrinology, Diabetes Mellitus and Metabolic Diseases, University Clinical Center of Sarajevo, Bosnia and Herzegovina.
authors.forename: Belma
authors.initials: B
authors.lastname: Ascić-Buturović
authors.forename: Semra
authors.initials: S
authors.lastname: Cavaljuga
mesh_terms: D000419:Albuminuria / Q000175:diagnosis; D000704:Analysis of Variance; D015415:Biomarkers; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D003404:Creatinine; D055316:Cystatin C; D015891:Cystatins; D006442:Glycated Hemoglobin; C525030:CST3 protein, human