Near death experiences: poxvirus regulation of apoptotic death.
Apoptosis, or programmed cell death, plays a critical role in the elimination of virus-infected cells. As a result, a growing number of viruses encode numerous potent anti-apoptotic proteins to counteract apoptosis in an effort to prolong their own survival. This review describes the numerous mechanisms by which poxviruses inhibit apoptosis thereby modulating life and death of the cell.
Taylor
John M
JM
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.
Barry
Michele
M
D000818:Animals; D000947:Antigens, Helminth; D017209:Apoptosis; D016923:Cell Death; D015801:Helminth Proteins; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D011212:Poxviridae / Q000378:metabolism / Q000502:physiology*; D011213:Poxviridae Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D015843:Serpins / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
D000947:Antigens, Helminth; D015801:Helminth Proteins; D051034:Inhibitor of Apoptosis Proteins; C052358:P28 antigen, Schistosoma; D018124:Receptors, Tumor Necrosis Factor; D015843:Serpins; D014764:Viral Proteins; C074641:interleukin-1beta-converting enzyme inhibitor; D044767:Ubiquitin-Protein Ligases