Strain-dependent differences in locomotor activity after local brain irradiation with 30 GyE of carbon ions.
This study investigated strain differences in brain damage among male A/J, C57BL/6JNrs and C3H/HeNrs mice after local brain irradiation. Whole brains were irradiated with a single dose of 30 GyE carbon ion beams and then locomotor activity was determined as body heat of each animal. The daily locomotor activities of untreated mice differed among strains. Non-irradiated C57BL/6JNrs mice were more active than A/J mice. This variance became more obvious immediately after irradiation, when the activity of A/J and C3H/HeNrs mice diminished, whereas that of C57BL/6JNrs mice increased at the beginning of the active phase and remained elevated for three days after irradiation. The altered activities of all three strains of irradiated mice gradually recovered to normal within three to four days.
Iwakawa
Mayumi
M
Frontier Research Center, National Institute of Radiological Institute, Anagawa, Inage-ku, Chiba, Japan.
Takai
Nobuhiko
N
Goto
Miyako
M
Noda
Shuhei
S
Ando
Koichi
K
Imai
Takashi
T
D000818:Animals; D001921:Brain / Q000528:radiation effects*; D002244:Carbon / Q000009:adverse effects*; D002250:Carbon Radioisotopes / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D013045:Species Specificity; D013997:Time Factors
D002250:Carbon Radioisotopes; D002244:Carbon