A triterpenoid saponin possessing antileishmanial activity from the leaves of Careya arborea.
Bioguided-fractionation of the methanol extract of the leaves of Careya arborea led to isolation of a triterpenoid saponin, designated arborenin, and characterized as 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl-2 alpha,3beta-dihydroxy-taraxast-20-en-28-oic acid (1), together with desacylescin III (2). The structures were determined on the basis of extensive 2D NMR spectroscopic analysis. The saponin showed in vitro antileishmanial activity against Leishmania donovani (strain AG 83).
Mandal
Debayan
D
Indian Institute of Chemical Biology, Department of Steroids and Terpenoids Chemistry, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India.
Panda
Nilendu
N
Kumar
Shrabanti
S
Banerjee
Sukdeb
S
Mandal
Nirup B
NB
Sahu
Niranjan P
NP
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D031381:Lecythidaceae / Q000737:chemistry*; D007893:Leishmania donovani / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D012015:Reference Standards; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes