title: Effects of propofol and fentanyl on duodenal motility activity in pigs.
abstract: To investigate the effects of propofol and fentanyl on the postprandial duodenal motility the intraluminal impedance technique was used. Six pigs were instrumented with a central venous catheter, a percutaneous enterogastrostomy (PEG), and an impedance catheter, which was introduced via the PEG into the duodenum through endoscopy. Over the following 3 d, duodenal motility was measured for 8-hour periods. Measurements were taken on each subject under 3 different sets of conditions: in the conscious unrestrained pig, during propofol sedation, and during sedation with propofol-fentanyl. Both, after morning feeding and during gastric nutrition via the PEG, duodenal feeding patterns and duodenal phase II of the migrating motor cycle were shortened during propofol and propofol-fentanyl sedation. In contrast, the duration of phase I was prolonged by propofol and propofol-fentanyl. In conclusion, either propofol or propofolfentanyl sedation shortens duodenal feeding patterns, as well as phase II of the migrating motor cycle.
authors.affiliation: Department of Anesthesiology, University Hospital Aachen, Aachen, Germany. joerg.schnoor@gmx.de
authors.forename: J
authors.initials: J
authors.lastname: Schnoor
authors.forename: J K
authors.initials: JK
authors.lastname: Unger
authors.forename: T
authors.initials: T
authors.lastname: Kuepper
authors.forename: B
authors.initials: B
authors.lastname: Bode
authors.forename: A
authors.initials: A
authors.lastname: Hofeditz
authors.forename: J
authors.initials: J
authors.lastname: Silny
authors.forename: R
authors.initials: R
authors.lastname: Rossaint
mesh_terms: D000818:Animals; D004384:Duodenoscopy / Q000662:veterinary; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D017097:Electric Impedance; D005283:Fentanyl / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D015742:Propofol / Q000494:pharmacology*; D011897:Random Allocation; D013552:Swine / Q000502:physiology*
chemical_list: D006993:Hypnotics and Sedatives; D005283:Fentanyl; D015742:Propofol