title: Intraoperative sentinel lymph node mapping using a new sterilizable magnetometer in patients with nonsmall cell lung cancer.
abstract: OBJECTIVE
  We recently developed a novel method for sentinel lymph node mapping using magnetic force. However, problems with the sterility and sensitivity of the magnetometer made intraoperative sentinel lymph node mapping impossible. The purpose of this study was to test the utility of a new, more sensitive, sterilizable magnetometer developed in our institute for in vivo sentinel lymph node mapping in patients with nonsmall cell lung cancer.
  
  
  METHODS
  Ferumoxides (magnetite) served as the tracer. Twenty patients with nonsmall cell lung cancer participated in the study. Each received 5 mL of ferumoxides, which were injected around their tumor. Magnetic force was then measured intraoperatively using the new sterilizable magnetometer.
  
  
  RESULTS
  The in vivo sentinel lymph node detection rate was 80.0% (16 of 20). The accuracy, sensitivity, and false-negative rates were 100% (16 of 16), 100% (4 of 4) and 0% (0 of 12), respectively. Our preliminary study indicates that our new magnetometer enables in vivo sentinel lymph node mapping in patients with nonsmall cell lung cancer.
  
  
  CONCLUSIONS
  This device safely and accurately detected sentinel lymph nodes in nonsmall cell lung cancer patients.
authors.affiliation: Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan. minamiya@med.akita-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Minamiya
authors.forename: Manabu
authors.initials: M
authors.lastname: Ito
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Katayose
authors.forename: Hajime
authors.initials: H
authors.lastname: Saito
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Imai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sato
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D003102:Colloids; D003911:Dextrans; D005188:False Negative Reactions; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D015552:Injections, Intralesional; D007501:Iron / Q000032:analysis; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008280:Magnetics / Q000295:instrumentation*; D058185:Magnetite Nanoparticles; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D010087:Oxides / Q000032:analysis; D010316:Particle Size; D011013:Pneumonectomy; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000295:instrumentation*; D013242:Sterilization; D013535:Suspensions
chemical_list: D003102:Colloids; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D013535:Suspensions; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide