Patients with prion disease: planning for eye surgery.
Human prion diseases are characterized by rapidly progressive fatal neurodegenerative symptoms. In prion diseases, neural tissues have the greatest potential for infectivity, and ocular tissues are included in the category of high infection risk. The Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) have published specific infection control guidelines for prion diseases. Standard Precautions are utilized for all patient care. Additional and more stringent measures are indicated when patients with known or suspected prion disease require ocular surgery. Measures include: notification of infection control, operating room, and decontamination personnel; use of disposable instruments whenever possible; special processing for non-disposable instruments; identification of tissue and laboratory specimens; and incineration or other appropriate treatment of infectious waste. Clumsiness, vision changes, and myoclonus in association with prion disease may predispose patients to traumatic ocular emergencies. Proactively, procedure areas should utilize a multidisciplinary approach to do the following: identify urgent surgical procedures that are likely to be required by these patients; evaluate cleaning procedures that will result in effective tissue removal; identify critical, non-disposable equipment for which there are no disposable alternatives; identify decontamination methods available to the specific facility as well as to identify which recommended decontamination procedures may not be appropriate for ocular instrumentation; and develop precautionary procedures specifically for decontamination of equipment and instruments.
O'Brien
Maureen A
MA
The Wilmer Eye Institute, Johns Hopkins Hospital, Wilmer Building, Room 504, 600 North Wolfe Street, Baltimore, Maryland 21287, USA.
Navarro
Victoria
V
Hancock
Cora
C
O'Brien
Terrence P
TP
D004866:Equipment Contamination / Q000517:prevention & control; D006801:Humans; D017053:Infection Control; D013508:Ophthalmologic Surgical Procedures; D017410:Practice Guidelines as Topic; D017096:Prion Diseases / Q000517:prevention & control; D013242:Sterilization / Q000379:methods; D013525:Surgical Instruments