The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations.
Loeb
Lawrence A
LA
Department of Pathology, University of Washington, Seattle, WA 98195, USA. laloeb@u.washington.edu
Wallace
Douglas C
DC
Martin
George M
GM
D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis; D001419:Bacteria; D016922:Cellular Senescence; D004249:DNA Damage; D000074002:DNA Polymerase gamma; D004272:DNA, Mitochondrial / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000473:pathology*; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D017382:Reactive Oxygen Species
D004272:DNA, Mitochondrial; D005609:Free Radicals; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase