title: Intratumor injections of cisplatin and laser thermal therapy for palliative treatment of recurrent cancer.
abstract: OBJECTIVE
  The aim of this work was to report initial findings on the clinical application of intratumor injection of cisplatin in a gel (CDDP/gel) combined with laser-induced thermal therapy (LITT) for cancer treatment in a single patient with advanced stage disease.
  
  
  BACKGROUND
  LITT with the neodymium:yttriumaluminum- garnet (Nd:YAG) laser via fiberoptics is a precise, minimally invasive alternative for thermoablation of unresectable or recurrent head and neck neoplasms, but recurrence is often seen at the treatment margins. Combining intratumor chemotherapy with interstitial laser should be most effective using drugs with thermally enhanced toxicity, such as cisplatin. The CDDP/gel therapeutic implant was expected to retain a higher concentration of cisplatin in the tumor margins for improved LITT treatment of the patient presented.
  
  
  METHODS
  In this case report, the cisplatin dose was 0.25 mL gel/cm(3) tumor volume (20 mg of CDDP) followed by LITT (Nd:YAG laser, 50 W, PD = 2,200 J/cm(2)) after the chemotherapy session.
  
  
  RESULTS
  The patient responded with local tumor eradication, and no signs of systemic toxicity were observed related to this therapy. However, the patient developed progressive metastatic disease in the lungs and died 2.5 months later.
  
  
  CONCLUSIONS
  This is a report of a patient with an accessible solid tumor who was treated with intratumor injection of CDDP/gel followed by LITT, which proved to be feasible. Based on preclinical evidence obtained at UCLA and the results of this study, we are encouraged to continue our refinement of LITT combined with chemotherapy for cancer treatment.
authors.affiliation: Department of Surgery, Division of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, 90095-1624, USA. mpaiva@mednet.ucla.edu
authors.forename: Marcos B
authors.initials: MB
authors.lastname: Paiva
authors.forename: Michael
authors.initials: M
authors.lastname: Bublik
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Castro
authors.forename: Matthew
authors.initials: M
authors.lastname: Udewitz
authors.forename: Marilene B
authors.initials: MB
authors.lastname: Wang
authors.forename: Luis Paulo
authors.initials: LP
authors.lastname: Kowalski
authors.forename: Joel
authors.initials: J
authors.lastname: Sercarz
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D005005:Ethmoid Sinus; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D015552:Injections, Intralesional; D053685:Laser Therapy; D008545:Melanoma / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010166:Palliative Care; D010255:Paranasal Sinus Neoplasms / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin