title: Intravenous contrast material administration in multislice computed tomography coronary angiography.
abstract: OBJECTIVE
  to compare contrast material (CM) administration protocols in non-invasive coronary angiography (CA) using a 16-row multislice CT (16-MSCT).
  
  
  METHODS
  45 patients undergoing CA with 16-MSCT were divided into three CM protocols: group 1 (140 ml@4ml/s), group 2 (140 ml = 60 ml@5ml/s + 80 ml@3ml/s), and group 3 (100 ml@4ml/s). The attenuation at the origin of the coronary vessels was assessed. Three regions of interest were evaluated: 1) ascending aorta (ROI1); 2) descending aorta (ROI2); 3) pulmonary artery (ROI3). The resulting time-density curves generated the average attenuation and the slope of bolus geometry.
  
  
  RESULTS
  the attenuation at the origin of the coronary vessels, and the average attenuation of bolus geometry were not significantly different (p > 0.05). The slope of bolus geometry was in ROI1 and ROI2 significantly lower for group 2, in ROI3 significantly lower for group 3 (p < 0.05).
  
  
  CONCLUSIONS
  100 ml of CM provide the same attenuation in 16-MSCT CA as mono- or multi-phasic 140 ml protocols.
authors.affiliation: Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands. filippocademartiri@hotmail.com
authors.forename: Filippo
authors.initials: F
authors.lastname: Cademartiri
authors.forename: Giacomo
authors.initials: G
authors.lastname: Luccichenti
authors.forename: Massimo
authors.initials: M
authors.lastname: Gualerzi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Brambilla
authors.forename: Valerio
authors.initials: V
authors.lastname: Brambilla
authors.forename: Paolo
authors.initials: P
authors.lastname: Coruzzi
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media