Highly efficient methods for the one-pot synthesis of beta-substituted enones.
A mild and practically-convenient one-pot procedure for the direct beta-substitution of enones has been developed using a conjugate addition-oxidation strategy with a full range of copper-based reagents and N-tert-butylphenylsulfinimidoyl chloride; alkyl- and aryl-substituted enones are delivered in good to excellent yields.
Kerr
William J
WJ
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UK G1 1XL. w.kerr@strath.ac.uk
Pearson
Colin M
CM
Thurston
Graeme J
GJ
D002625:Chemistry, Organic / Q000379:methods; D003300:Copper; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013441:Sulfinic Acids / Q000737:chemistry
D007202:Indicators and Reagents; D007659:Ketones; D013441:Sulfinic Acids; D003300:Copper