title: Advances in glycoprotein synthesis.
abstract: The development of chemical and enzymatic methods for the synthesis of homogeneous glycoproteins is a fascinating challenge at the interface between chemistry and biology. Discussed here are the currently available methods for preparation of homogeneous glycoproteins. These methods include (1) glycopeptide ligation; (2) glycoprotein remodeling; and (3) in vivo suppressor tRNA technology.
authors.affiliation: Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Clay S
authors.initials: CS
authors.lastname: Bennett
authors.forename: Chi-Huey
authors.initials: CH
authors.lastname: Wong
mesh_terms: D002236:Carbohydrate Conformation; D006023:Glycoproteins / Q000138:chemical synthesis*; D008958:Models, Molecular; D010447:Peptide Hydrolases; D011487:Protein Conformation
chemical_list: D006023:Glycoproteins; D010447:Peptide Hydrolases