title: Mechanical thrombolysis in ischemic stroke attributable to basilar artery occlusion as first-line treatment.
abstract: OBJECTIVE
  To report results of mechanical disruption or retrieval of thrombus as first-line treatment in patients with stroke attributable to occlusion of the basilar artery, in particular regarding efficiency and safety.
  
  
  METHODS
  In 12 consecutive patients with acute stroke attributable to basilar occlusion, mechanical disruption or thrombus retrieval using various loop-shaped tools was tried before eventually starting local intra-arterial thrombolysis with recombinant tissue plasminogen activator (r-tPA). Main inclusion criteria were: National Institutes of Health Stroke Scale score >8 or Glasgow Coma Scale score <12; onset or worsening of symptoms <8 hours; no hemorrhages or large hypodensities on computed tomography scan; and occlusion of the basilar artery matching clinical symptoms. Efficiency included recanalization, procedure time, and r-tPA dose; safety was defined as rate of procedure-related complications. Outcome was evaluated at 3 months.
  
  
  RESULTS
  Mechanical recanalization was successful in 6 patients. A single brain infarction, possibly attributable to distal embolization, occurred. Three patients had good outcomes. In 5 of 6 remaining patients, the artery was recanalized using r-tPA. A single asymptomatic hemorrhage occurred; 3 patients had good outcomes. Procedure time and r-tPA were significantly less in patients with successful mechanical thrombolysis (43.33 minutes and 13.33 mg versus 112.33 minutes and 55.83 mg, respectively).
  
  
  CONCLUSIONS
  Mechanical recanalization was effective in half of the patients and at least as safe as local intra-arterial thrombolysis. It allowed to save r-tPA and time. Although the low success rate remains a limit, the excellent and quick anatomical recanalization obtained after successful procedures makes this approach promising.
authors.affiliation: Neuroscience Department, S.G. Battista Hospital, University of Turin, Italy. mauro.bergui@unito.it
authors.forename: Mauro
authors.initials: M
authors.lastname: Bergui
authors.forename: Guido
authors.initials: G
authors.lastname: Stura
authors.forename: Dino
authors.initials: D
authors.lastname: Daniele
authors.forename: Paolo
authors.initials: P
authors.lastname: Cerrato
authors.forename: Maurizio
authors.initials: M
authors.lastname: Berardino
authors.forename: Gianni Boris
authors.initials: GB
authors.lastname: Bradac
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000601:surgery / Q000628:therapy*; D001488:Basilar Artery / Q000473:pathology; D001933:Brain Stem / Q000473:pathology; D017128:Embolectomy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000737:chemistry; D020521:Stroke / Q000601:surgery / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator