title: [Effect of iron ions on the antioxidant enzyme activities in yeast Saccharomyces cerevisiae].
abstract: A complex of physiological and biochemical indices has been compared in wild and isogenic catalase-deficient strains of Saccharomyces cerevisiae grown on the media with different iron ion concentrations is 2 times higher in cytosolic catalase deficient yeast. Superoxide dismutase activity grown in the medium with 500 microM of ferrous sulphate. Under such conditions, peroxisomal catalase deficient yeast had a 2-fold decreased activity of superoxide dismutase. There is a significant difference between TBA-reactive substances content of the wild and cytosolic catalase deficient strain. It has been suggested that the repletion of iron ions in the growth medium leads to the formation of lipid oxidation products. Catalase prevents TBA-reactive substances formation in the given conditions and plays a protective role.
authors.forename: D V
authors.initials: DV
authors.lastname: Hospodar'ov
authors.forename: V I
authors.initials: VI
authors.lastname: Lushchak
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005296:Ferrous Compounds / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
chemical_list: D000975:Antioxidants; D005296:Ferrous Compounds; D029701:Saccharomyces cerevisiae Proteins; D017392:Thiobarbituric Acid Reactive Substances; C020748:ferrous sulfate; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005952:Glucose-6-Phosphatase