Molecular motors hijacking by intracellular pathogens.
Cargoes are transported intracellularly along cytoskeletal tracks composed of actin or tubulin. Their movement involves the action of molecular motor proteins that generate directed movement along microtubules or actin filaments. The three classes of molecular motors--kinesins, dyneins and myosins--are involved in a multiplicity of biological movements such as mitosis, positioning of organelles, intracellular transports and also vesicular sorting through membrane tubulation and fission and delivery to their target compartment. Intracellular pathogens use this molecular machinery to reach their site of replication, to leave their host or to control the dynamics of membrane exchanges with their replication compartment.
Henry
Thomas
T
Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université Méditerranée, Parc Scientifique de Luminy, Case 906-13288 Marseille Cedex 9, France.
Gorvel
Jean-Pierre
JP
Méresse
Stéphane
S
D000199:Actins / Q000502:physiology; D001424:Bacterial Infections / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D001693:Biological Transport, Active; D004398:Dyneins / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D016547:Kinesins / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D020409:Molecular Motor Proteins / Q000502:physiology*; D009218:Myosins / Q000502:physiology; D012475:Salmonella / Q000502:physiology; D014404:Tubulin / Q000502:physiology; D014777:Virus Diseases / Q000378:metabolism; D018406:Virus Physiological Phenomena
D000199:Actins; D020409:Molecular Motor Proteins; D014404:Tubulin; D009218:Myosins; D004398:Dyneins; D016547:Kinesins