title: Cocaine improves inhibitory control in a human model of response conflict.
abstract: The present study was designed to test the acute effects of cocaine on behavioral control in the presence and absence of motivational conflict. Adults (N = 14) with a history of stimulant use received oral cocaine hydrogen chloride (0, 100, 200, and 300 mg) and performed a cue-dependent go/no-go task to measure inhibitory and activational mechanisms of behavioral control either with or without motivated conflict between the inhibition and the activation of responses. Cocaine improved response inhibition in both conflict conditions, as evident by a decrease in inhibitory failures following active doses. The current study provides a useful model to investigate the effects of other drugs reported to have performance-enhancing effects.
authors.affiliation: Department of Psychology, University of Kentucky, Lexington, 40506, USA. fillmore@uky.edu
authors.forename: Mark T
authors.initials: MT
authors.lastname: Fillmore
authors.forename: Craig R
authors.initials: CR
authors.lastname: Rush
authors.forename: Lon
authors.initials: L
authors.lastname: Hays
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D001519:Behavior / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002214:Capsules; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003220:Conflict, Psychological; D003463:Cues; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011930:Reaction Time / Q000187:drug effects*; D011795:Surveys and Questionnaires; D013647:Task Performance and Analysis; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D002214:Capsules; D003042:Cocaine