Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid.
The authors studied 40 epileptic patients treated with valproate and 40 healthy controls for at least 2 years. At the end of follow-up, 15 epileptic patients (37.5%) had development of obesity. They showed circulating leptin and insulin levels significantly higher and ghrelin and adiponectin levels significantly lower than those of patients who did not gain weight.
Greco
R
R
Department of Medicine, University of Chieti, Italy.
Latini
G
G
Chiarelli
F
F
Iannetti
P
P
Verrotti
A
A
D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D054439:Ghrelin; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D036361:Peptide Hormones / Q000097:blood*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D014635:Valproic Acid / Q000009:adverse effects*
D052242:Adiponectin; D000927:Anticonvulsants; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D036361:Peptide Hormones; D014635:Valproic Acid