New World monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity.
Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.
Jones
Franca R
FR
Naval Medical Research Center, Biological Defense Research Directorate, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. jonesf@nmrc.navy.mil
Baqar
Shahida
S
Gozalo
Alfonso
A
Nunez
Gladys
G
Espinoza
Nereyda
N
Reyes
Sharina M
SM
Salazar
Milagros
M
Meza
Rina
R
Porter
Chad K
CK
Walz
Stephen E
SE
D000818:Animals; D016645:Aotidae; D002169:Campylobacter Infections / Q000276:immunology* / Q000517:prevention & control; D016123:Campylobacter jejuni / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D007117:Immunization, Secondary; D008297:Male