Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents.
This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-HT(1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Rats ovariectomized 3, 6 and 12 weeks previously, were tested in the burying behaviour paradigm and in an automatic activity counter. The highest values of time spent burying were observed in the 12-week group. In general, the 12-week group was more responsive to diazepam than the 3-week group, while 8-OH-DPAT showed similar effects on time spent burying, independently of how long ago the ovariectomy was done. Detection of anxiogenic-like behaviours by the shock-probe burying test in rats after chronic absence of gonadal hormones could help in the understanding of mood changes associated with human menopause.
Picazo
Ofir
O
Escuela Superior de Medicina del IPN Plan de San Luis y Diaz Mirón, Col. Sto. Tomás, México DF. rifo99mx@yahoo.com
Estrada-Camarena
Erika
E
Hernandez-Aragon
Azucena
A
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003975:Diazepam