title: [Thinking and challenge induced by the hypothesis of breaking stagnant and eliminating blood stasis in Treating acute cerebral hemorrhage by rF VII a].
abstract: Definite therapeutic effect has obtained by TCM in treating acute cerebral hemorrhage (ACH) according the TCM theory of "blood circulating outside the vessels is the stasis" using breaking stagnant and eliminating blood stasis (Poxue Zhuyu) method, but no material involving the natural development of stoke in superacue stage (0 - 4 hrs after onset of the disease) being presented so far. It has been proved by randomized, double-blinded multi-centeric clinical trials that recombinant activated factor VII (rF VII a) could decreased the morbidity and disability of patients suffered from ACH, suggesting that use hemostasis treatment in ACH during superacu stage should be stressed, and the drugs for Poxue Zhuyu should be used cautiously in the period of 0 - 4 hrs after onset. The hemorrhagic disorder could be eliminated by using drugs for Poxue Zhuyu and other medicines in rational combination.
authors.affiliation: ment of Neurology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou. guojianwen1008@yahoo.com.cn
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Guo
authors.forename: Ye-feng
authors.initials: YF
authors.lastname: Cai
authors.forename: Bao-xin
authors.initials: BX
authors.lastname: Du
mesh_terms: D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015942:Factor VIIa / Q000096:biosynthesis / Q000235:genetics / Q000627:therapeutic use; D006801:Humans; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000627:therapeutic use
chemical_list: D004365:Drugs, Chinese Herbal; D011994:Recombinant Proteins; D015942:Factor VIIa