title: [Prophylactic treatment of oral sildenafil citrate for pulmonary hypertension in an infant treated with inhaled nitric oxide after open-heart surgery].
abstract: A 3-month-old boy with coarctation of the aorta (CoA), ventricular septal defect (VSD), atrial septal defect, and severe pulmonary hypertension (PH) underwent one-stage repair consisting of patch closure of VSD and coarctation repair. Inhalation of nitric oxide (iNO) was commenced to treat residual severe PH on the day of the operation. Oral sildenafil citrate was commenced on the day 1 and iNO was gradually weaned off on the day 3. There was no "rebound", severe increase in pulmonary artery pressure, which commonly occurs after discontinuation of iNO. Then the patient was extubated without any difficulties or recurrent PH. The oral sildenafil citrate therapy was ceased on the day 8. Prophylactic use of oral sildenafil citrate for PH might be an useful alternative to shorten the duration of iNO therapy and intensive care unit (ICU) stay in the selected patients after congenital open heart surgery.
authors.affiliation: Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Nakatsu
authors.forename: S
authors.initials: S
authors.lastname: Nemoto
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Saji
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Nishina
authors.forename: N
authors.initials: N
authors.lastname: Ohno
authors.forename: M
authors.initials: M
authors.lastname: Komeda
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D001017:Aortic Coarctation / Q000150:complications / Q000601:surgery; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures; D002675:Child, Preschool; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery; D006801:Humans; D006976:Hypertension, Pulmonary / Q000517:prevention & control*; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D010879:Piperazines / Q000008:administration & dosage*; D011184:Postoperative Period; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D001993:Bronchodilator Agents; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D009569:Nitric Oxide; D000068677:Sildenafil Citrate