title: [Immunological and clinical study on therapeutic efficacy of inosine pranobex].
abstract: Many studies in vitro and in vivo have shown immunomodulating and antiviral activities of inosine pranobex. The object of this research was to examine the potential beneficial effects of inosine pranobex (Groprinosin) on immune system in children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin. 50 mg/kg b.w/day of inosine pranobex in divided doses was given to the group of 30 children aged 3-15 years for 10 days in 3 following months. Clinical and immunological investigations were done before and after the treatment. Statistically significant rise of CD3T lymphocytes number (p = 0.02) and in this CD4T lymphocytes number (p = 0.02) as well as statistically significant improvement of their function (p = 0.005) evaluated with blastic transformation method were found. These laboratory findings were parallel to clinical benefits. Control study was performed in the group of children completed by randomization and treated in the same way with garlic (Alliofil).
authors.affiliation: Zakład Immunologii Klinicznej Instytutu Matki i Dziecka, Warszawie. immunolog@imid.med.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Gołebiowska-Wawrzyniak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Markiewicz
authors.forename: Agata
authors.initials: A
authors.lastname: Kozar
authors.forename: Piotr
authors.initials: P
authors.lastname: Derentowicz
authors.forename: Iwona
authors.initials: I
authors.lastname: Czerwińska-Kartowicz
authors.forename: Krystyna
authors.initials: K
authors.lastname: Jastrzebska-Janas
authors.forename: Jolanta
authors.initials: J
authors.lastname: Wacławek
authors.forename: Zbigniew M
authors.initials: ZM
authors.lastname: Wawrzyniak
authors.forename: Henryka
authors.initials: H
authors.lastname: Siwińska-Gołebiowska
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000490:Allium; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017252:CD3 Complex / Q000187:drug effects; D015704:CD4 Antigens / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D028321:Plant Preparations / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects*; D016896:Treatment Outcome; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D017252:CD3 Complex; D015704:CD4 Antigens; D028321:Plant Preparations; D007542:Inosine Pranobex