title: BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study.
abstract: Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
authors.affiliation: Department of Neurology, Boston University School of Medicine, MA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Karamohamed
authors.forename: J C
authors.initials: JC
authors.lastname: Latourelle
authors.forename: B A
authors.initials: BA
authors.lastname: Racette
authors.forename: J S
authors.initials: JS
authors.lastname: Perlmutter
authors.forename: G F
authors.initials: GF
authors.lastname: Wooten
authors.forename: M
authors.initials: M
authors.lastname: Lew
authors.forename: C
authors.initials: C
authors.lastname: Klein
authors.forename: H
authors.initials: H
authors.lastname: Shill
authors.forename: L I
authors.initials: LI
authors.lastname: Golbe
authors.forename: M H
authors.initials: MH
authors.lastname: Mark
authors.forename: M
authors.initials: M
authors.lastname: Guttman
authors.forename: G
authors.initials: G
authors.lastname: Nicholson
authors.forename: J B
authors.initials: JB
authors.lastname: Wilk
authors.forename: M
authors.initials: M
authors.lastname: Saint-Hilaire
authors.forename: A L
authors.initials: AL
authors.lastname: DeStefano
authors.forename: R
authors.initials: R
authors.lastname: Prakash
authors.forename: S
authors.initials: S
authors.lastname: Tobin
authors.forename: J
authors.initials: J
authors.lastname: Williamson
authors.forename: O
authors.initials: O
authors.lastname: Suchowersky
authors.forename: N
authors.initials: N
authors.lastname: Labell
authors.forename: B N J
authors.initials: BN
authors.lastname: Growdon
authors.forename: C
authors.initials: C
authors.lastname: Singer
authors.forename: R
authors.initials: R
authors.lastname: Watts
authors.forename: S
authors.initials: S
authors.lastname: Goldwurm
authors.forename: G
authors.initials: G
authors.lastname: Pezzoli
authors.forename: K B
authors.initials: KB
authors.lastname: Baker
authors.forename: M L
authors.initials: ML
authors.lastname: Giroux
authors.forename: P P
authors.initials: PP
authors.lastname: Pramstaller
authors.forename: D J
authors.initials: DJ
authors.lastname: Burn
authors.forename: P
authors.initials: P
authors.lastname: Chinnery
authors.forename: S
authors.initials: S
authors.lastname: Sherman
authors.forename: P
authors.initials: P
authors.lastname: Vieregge
authors.forename: I
authors.initials: I
authors.lastname: Litvan
authors.forename: J F
authors.initials: JF
authors.lastname: Gusella
authors.forename: R H
authors.initials: RH
authors.lastname: Myers
authors.forename: A
authors.initials: A
authors.lastname: Parsian
mesh_terms: D017668:Age of Onset; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004252:DNA Mutational Analysis; D005192:Family Health; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006720:Homozygote; D015233:Models, Statistical; D020734:Parkinsonian Disorders / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor