title: [Age-dependent cadmium accumulation in organs of intoxicated rats and changes of indices of acid-base balance of blood in different conditions of antioxidant defence].
abstract: Age peculiarities of cadmium cumulation in the organs of rats under different conditions of antioxidants administration. Considerable hepato- and nefrotoxic effect of the given xenobiotic under different conditions of its supply into the organism was revealed. The strongly pronounced differences between the age distribution of cadmium in the organisms have been marked. It is proved that the most antioxidantal activity is shown by sodium selenite when administered into the organism before poisoning with cadmium. It is stated that the indices showing the acid-alkaline state are subject to the greatest changes in the bodies of young animals. In this case they have more expressed toxic effects under the influence of ions of heavy metals as well as the receptivity to the positive influence of antioxidants.
authors.forename: D O
authors.initials: DO
authors.lastname: Mel'nychuk
authors.forename: N M
authors.initials: NM
authors.lastname: Mel'nykova
authors.forename: Ie A
authors.initials: IeA
authors.lastname: Derkach
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000375:Aging / Q000097:blood* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019187:Cadmium Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D013431:Sulfates / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D019187:Cadmium Compounds; D013431:Sulfates; C037123:cadmium sulfate