title: Neurofibromatosis 2 (NF2) and malignant mesothelioma in a man with a constitutional NF2 missense mutation.
abstract: Neurofibromatosis 2 (NF2) is caused by inactivating mutations of the NF2 tumor suppressor gene. Somatic NF2 mutations also occur in a high proportion of human primary malignant mesotheliomas. We report an elderly man with NF2, malignant mesothelioma, and a constitutional NF2 missense mutation. The long latent period for mesothelioma in this patient (61 years) raises the possibility that the type of mutant NF2 allele could affect mesothelioma tumorigenesis or progression.
authors.affiliation: michael.baser@verizon.net
authors.forename: M E
authors.initials: ME
authors.lastname: Baser
authors.forename: H
authors.initials: H
authors.lastname: Rai
authors.forename: A J
authors.initials: AJ
authors.lastname: Wallace
authors.forename: D G R
authors.initials: DG
authors.lastname: Evans
mesh_terms: D000368:Aged; D001194:Asbestos / Q000009:adverse effects; D016515:Genes, Neurofibromatosis 2; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000150:complications* / Q000235:genetics*; D020125:Mutation, Missense; D016518:Neurofibromatosis 2 / Q000150:complications / Q000235:genetics*; D009464:Neuroma, Acoustic / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D010997:Pleural Neoplasms / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction
chemical_list: D001194:Asbestos