title: The effects of ethanol ingestion on the accuracy of pulmonary diffusing capacity measurement.
abstract: BACKGROUND
  Erroneous diffusing capacity of the lung for carbon monoxide (Dlco) values as measured by spectrophotometry were observed at our facility in ethanol-intoxicated subjects. An atypical methane curve tracing was noted in these subjects.
  
  
  OBJECTIVE
  We hypothesized that ethanol intoxication interferes with Dlco measurements obtained using methane and designed a study to assess the blood ethanol level at which this occurs.
  
  
  METHODS
  Dlco and breath ethanol levels were measured at baseline and after escalating doses of ethanol in seven healthy subjects.
  
  
  METHODS
  Pulmonary function testing laboratory of a university hospital.
  
  
  METHODS
  Seven healthy volunteers.
  
  
  METHODS
  Dlco measurement at baseline and after escalating doses of ethanol.
  
  
  RESULTS
  We found no significant change in measured Dlco values for a wide range of blood ethanol levels (from 0.006 to 0.12 mg/dL). However, subsequently, an abnormal methane curve and Dlco were again observed in an intoxicated subject whose ethanol blood level was 0.22 mg/dL.
  
  
  CONCLUSIONS
  We conclude that interference between breath ethanol level and Dlco measurement exists only for blood ethanol levels well above the legal limit for intoxication. Based on our observations, we suggest that ethanol intoxication should be suspected when an abnormal Dlco measurement occurs along with an abnormal methane curve tracing. If intoxication is confirmed, precautions should be taken and referral for treatment of possible ethanol dependence should be offered.
authors.affiliation: Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave, SL-9, New Orleans, LA 70112, USA.
authors.forename: Francesco
authors.initials: F
authors.lastname: Simeone
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wiese
authors.forename: Henry
authors.initials: H
authors.lastname: Glindmeyer
authors.forename: Joseph
authors.initials: J
authors.lastname: Lasky
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology*; D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000431:Ethanol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011653:Pulmonary Diffusing Capacity / Q000502:physiology*; D011659:Pulmonary Gas Exchange; D012016:Reference Values; D012129:Respiratory Function Tests; D012307:Risk Factors
chemical_list: D000431:Ethanol