title: Performance and reliability of the CPB/ECMO Initiative Forward Lines Casualty Management System.
abstract: The Cleveland Clinic Foundation CPB/ECMO Initiative Forward Casualty Management System is an economical, compact, transportable, disposable system designed to permit a rapid expansion of trauma management services requiring cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) pulmonary support. The system, composed of a rotary blood pump, a pump motor driver, and an electronic control console as the blood pumping subsystem, also includes commonly used compatible commercial oxygenators, venous reservoirs, and cannulae. In vitro durability testing accumulated over 100 hours without failure. In vivo reliability was tested in 10 calves under general anesthesia during 6 hours of CPB and ECMO under full heparinization at nominal operating conditions of 4-5 l/min and 2-4 l/min blood flow respectively, and mean arterial pressures between 65 and 100 mm Hg. A mean time to failure of 57 hours was reached during the animal series. Results of these test series demonstrated that this system has the capability to reliably operate during a 6-hour conventional CPB or ECMO procedure, while providing flexibility and ease of use for the operator.
authors.affiliation: Lerner Research Institute, Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. casasf@ccf.org
authors.forename: Fernando
authors.initials: F
authors.lastname: Casas
authors.forename: Andrew
authors.initials: A
authors.lastname: Reeves
authors.forename: David
authors.initials: D
authors.lastname: Dudzinski
authors.forename: Stephan
authors.initials: S
authors.lastname: Weber
authors.forename: Markus
authors.initials: M
authors.lastname: Lorenz
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akiyama
authors.forename: Keiji
authors.initials: K
authors.lastname: Kamohara
authors.forename: Michael
authors.initials: M
authors.lastname: Kopcak
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Firas
authors.initials: F
authors.lastname: Zahr
authors.forename: Martin
authors.initials: M
authors.lastname: Sinkewich
authors.forename: Robert
authors.initials: R
authors.lastname: Foster
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: William A
authors.initials: WA
authors.lastname: Smith
mesh_terms: D000818:Animals; D002417:Cattle; D001026:Coronary Artery Bypass / Q000191:economics / Q000295:instrumentation; D003365:Costs and Cost Analysis; D019468:Disease Management; D004209:Disposable Equipment; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000191:economics / Q000295:instrumentation; D006801:Humans; D008297:Male; D008887:Military Medicine; D015203:Reproducibility of Results; D014947:Wounds and Injuries / Q000628:therapy