title: HLA-DRB1 genotyping in Italian migraine patients.
abstract: We examined the distribution of HLA-DRB1 alleles in a cohort 255 Italian migraine patients and in a control group of 325 healthy subjects. 214 patients fulfilled the ICHD-II criteria for migraine without aura and 41 patients the criteria for migraine with aura. The frequency of DRB1*16 allele was found to be significantly increased in migraine without aura patients (p=0.02; OR 1.97, 95% CI: 1.10-3.54) than in healthy controls. The frequencies of HLA-DRB1 alleles were not significantly different between migraine with aura patients and controls. We did not detect any effect of DRB1 alleles on age at onset, duration of the disease, frequency and duration of migraine attacks. Our data suggest the presence of a genetic susceptibility factor for migraine without aura within the HLA region.
authors.affiliation: Neurology III-Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy. irainero@molinette.piemonte.it
authors.forename: Innocenzo
authors.initials: I
authors.lastname: Rainero
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Dall'Omo
authors.forename: Elisa
authors.initials: E
authors.lastname: Rubino
authors.forename: Walter
authors.initials: W
authors.lastname: Valfrè
authors.forename: Maria Edvige
authors.initials: ME
authors.lastname: Fasano
authors.forename: Chiara
authors.initials: C
authors.lastname: Rivoiro
authors.forename: Francesca
authors.initials: F
authors.lastname: Brancatello
authors.forename: Lidia
authors.initials: L
authors.lastname: Savi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gallone
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pinessi
mesh_terms: D000328:Adult; D000483:Alleles; D015331:Cohort Studies; D016001:Confidence Intervals; D003710:Demography; D004827:Epilepsy / Q000150:complications / Q000235:genetics; D005260:Female; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000145:classification / Q000150:complications / Q000235:genetics*; D016017:Odds Ratio
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains