Epidemiologic pictures of Kawasaki disease in Shanghai from 1998 through 2002.
BACKGROUND
Epidemiologic features of Kawasaki disease in China is still not clear.


METHODS
A questionnaire form and diagnostic guidelines for Kawasaki disease were sent to hospitals in Shanghai, which provided with pediatric medical care. All patients with Kawasaki disease diagnosed during January 1998 through December 2002 were recruited in this study.


RESULTS
A total of 768 patients with Kawasaki disease were reported. The incidence rates of Kawasaki disease for each year were 16.79 (1998), 25.65 (1999), 28.16 (2000), 28.05 (2001), and 36.76 (2002) per 100,000 children under 5 years of age. The male/female ratio was 1.83:1. The age at onset ranged from 1 month to 18.8 years (median: 1.8 years). The disease occurred more frequently in spring and summer. Fever was the most common clinical symptom, followed by oral changes, extremities desquamate, rash, conjunctive congestion, lymphadenopathy, extremities swelling, and crissum desquamate. Cardiac abnormalities were found in 24.3% of patients. The most common cardiac abnormality was coronary artery lesions including dilatation (68%) and aneurysm (10%). The case-fatality rate at acute stage of the disease was 0.26%. A second onset of the disease occurred in 1.82% of patients.


CONCLUSIONS
The incidence rate of Kawasaki disease in Shanghai is lower than that reported in Japan, but higher than those in western countries. The increasing trend in incidence, sex distribution and cardiac abnormalities are similar to those in previous reports. The seasonal distribution is similar to the report from Beijing and different from other reports.
Huang
Guo-Ying
GY
Children's Hospital of Fudan University, Department of Pediatrics of Shanghai Medical College, People's Republic of China. gyhuang@shmu.edu.cn
Ma
Xiao-Jing
XJ
Huang
Min
M
Chen
Shu-Bao
SB
Huang
Mei-Rong
MR
Gui
Yong-Hao
YH
Ning
Shou-Bao
SB
Zhang
Tuo-Hong
TH
Du
Zhong-Dong
ZD
Yanagawa
Hiroshi
H
Kawasaki
Tomisaku
T
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012621:Seasons; D011795:Surveys and Questionnaires; D005719:gamma-Globulins / Q000627:therapeutic use
D005719:gamma-Globulins