High prevalence of patent foramen ovale in migraine with aura.
In this study we evaluated the presence of patent foramen ovale (PFO) in a cohort of 25 consecutive patients suffering from migraine with aura (MA) during an attack presenting to the emergency ward of an Italian hospital. Patients underwent brain magnetic resonance imaging (MRI) with contrast medium, routine coagulation tests, contrast transcranial echocolour-coded sonography (c-TCCS) and transoesophageal echocardiography (TEE). Of the enrolled patients, 88.7% showed a PFO according to the c-TCCS test, whereas only in 72% TEE confirmed the presence of PFO. This discordance could be due to the fact that c-TCCS is more sensitive even with shunts with minimal capacity also located in the pulmonary vasculature. After surgical treatment of the PFO, MA disappeared within two months. Also, the treatment with warfarin as well as with acetylsalicylic acid and flunarizine was able to dramatically reduce the frequency of migraine attacks. These data indicate a higher prevalence of PFO in MA vs. normal population (OR=2.92) and could suggest that the presence of arteriovenous (AV) shunts could represent a trigger for MA attacks as well as for stroke, but more studies are needed to confirm this preliminary hypothesis.
Ferrarini
Giovanni
G
Centro Cefalee Alta Specialità, Dipartimento Area Critica, Reggio Emilia, Italy.
Malferrari
Giovanni
G
Zucco
Riccardo
R
Gaddi
Oscar
O
Norina
Marcello
M
Pini
Luigi Alberto
LA
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D017548:Echocardiography, Transesophageal; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D015995:Prevalence; D017585:Ultrasonography, Doppler, Transcranial
D000925:Anticoagulants; D002121:Calcium Channel Blockers; D005444:Flunarizine