Novel Allylic Oxidation of alpha-Cedrene to sec-Cedrenol by a Rhodococcus Strain.
A bacterial strain, designated KSM-7358, that can use alpha-cedrene for growth was isolated. The strain was identified as a member of the genus Rhodococcus and catalyzed the novel allylic oxidation of alpha-cedrene regiospecifically to produce (R)-10-hydroxycedrene (sec-cedrenol) with a very high yield. alpha-Curcumene was also produced as a possible metabolite of sec-cedrenol. A possible pathway for the microbial conversion of alpha-cedrene to sec-cedrenol and alpha-curcumene is proposed.
Takigawa
H
H
Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, and Wakayama Research Laboratories of Kao Corporation, 1334 Minato, Wakayama 640, Japan.
Kubota
H
H
Sonohara
H
H
Okuda
M
M
Tanaka
S
S
Fujikura
Y
Y
Ito
S
S