Plasma levels of insulin and amyloid beta 42 are correlated in patients with amnestic Mild Cognitive Impairment.
Epidemiological and experimental data suggest that type 2 diabetes (DM2) and sporadic late-onset Alzheimer's disease (AD) share a common mechanism, that is able to produce accumulation of insulin and amyloid beta 42 (Abeta42), the major pathogenic events respectively of the two conditions. In 71 non diabetic patients with amnestic mild cognitive impairment we found a significant linear correlation between fasting plasma levels of insulin and Abeta42 (R = +0.25, P < 0.05). The levels of both peptides were elevated in comparison to 48 age-matched cognitively normal controls. The correlation of insulin and Abeta42 plasma levels suggests a pathogenic link between DM2 and sporadic AD.
Odetti
Patrizio
P
Gerontology and Geriatrics, Department of Internal Medicine University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy.
Piccini
Alessandra
A
Giliberto
Luca
L
Borghi
Roberta
R
Natale
Alessia
A
Monacelli
Fiammetta
F
Marchese
Monica
M
Assini
Andrea
A
Colucci
Monica
M
Cammarata
Sergio
S
Tabaton
Massimo
M
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism; D000647:Amnesia / Q000453:epidemiology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003072:Cognition Disorders / Q000453:epidemiology / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism*; D012720:Severity of Illness Index
D016229:Amyloid beta-Peptides; D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)