title: Physical and biological characterizations of a novel multiphase anodic spark deposition coating to enhance implant osseointegration.
abstract: The present study assessed in vitro the short-term cellular response to surface physico-chemical properties of a new, purposed bioactive surface treatment called BioSpark performed on simply machined and on sand-blasted titanium. Material characterisation was carried out using scanning electron microscopy, energy dispersion spectroscopy, laser profilometry, and thin film X-ray diffraction. The in vitro biological study showed a suitable cellular response with adhesion and spreading level comparable for all the tested specimens. The proliferation analysis demonstrated that all the surfaces successfully supported cellular colonisation; in particular, higher cellular proliferation activity was observed on the BioSpark-treated materials, with values higher than machined titanium. The results suggest that the BioSpark treatment represents a smart way to enhance osteoblastic cellular colonisation and thus improve osteointegration processes of machined and sandblasted titanium for orthopaedic and dental implants.
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering G.Natta', Polytechnic of Milan, Via Mancinelli, 7, Milan, Italy. carmen.giordano@polimi.it
authors.forename: Carmen
authors.initials: C
authors.lastname: Giordano
authors.forename: Roberto
authors.initials: R
authors.lastname: Chiesa
authors.forename: Enrico
authors.initials: E
authors.lastname: Sandrini
authors.forename: Alberto
authors.initials: A
authors.lastname: Cigada
authors.forename: Gianluca
authors.initials: G
authors.lastname: Giavaresi
authors.forename: Milena
authors.initials: M
authors.lastname: Fini
authors.forename: Roberto
authors.initials: R
authors.lastname: Giardino
mesh_terms: D001842:Bone and Bones; D002448:Cell Adhesion; D002460:Cell Line; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D019736:Prostheses and Implants; D014961:X-Ray Diffraction