title: Fragrance contact dermatitis in Korea: a joint study.
abstract: The purpose of this study is to determine the frequency of responses to selected fragrances in patients with suspected fragrance allergy and to evaluate the risk factors. 9 dermatology departments of university hospitals have participated in this study for the past 1 year. To determine allergic response to fragrances, 18 additional fragrances in addition to the Korean standard and a commercial fragrance series were patch-tested in patients with suspecting cosmetic contact dermatitis. Over 80% of the patients were women, and the most common site was the face. Cinnamic alcohol and sandalwood oil (Santalum album L.) showed high frequencies of positive responses. Of the specific fragrances, ebanol, alpha-isomethyl-ionone (methyl ionone-gamma) and Lyral (hydroxyisohexyl 3-cyclohexane carboxdaldehyde) showed high positive responses. We compared the results obtained during this study with those of other studies and concluded that including additional fragrance allergens may be useful for the detection of fragrance allergy.
authors.affiliation: AmorePacific Corporation, R&D Center, Yongin, Korea.
authors.forename: Susun
authors.initials: S
authors.lastname: An
authors.forename: Ai-Young
authors.initials: AY
authors.lastname: Lee
authors.forename: Cheol Heon
authors.initials: CH
authors.lastname: Lee
authors.forename: Do-Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Hahm
authors.forename: Kea-Jeung
authors.initials: KJ
authors.lastname: Kim
authors.forename: Kee-Chan
authors.initials: KC
authors.lastname: Moon
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Won
authors.forename: Young-Suck
authors.initials: YS
authors.lastname: Ro
authors.forename: Hee Chul
authors.initials: HC
authors.lastname: Eun
mesh_terms: D000447:Aldehydes / Q000009:adverse effects; D000485:Allergens; D053138:Cyclohexenes; D003517:Cyclopentanes / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D045792:Norisoprenoids / Q000009:adverse effects; D010328:Patch Tests; D000439:Pentanols / Q000009:adverse effects; D010476:Perfume / Q000009:adverse effects*; D010938:Plant Oils / Q000009:adverse effects; D020005:Propanols / Q000009:adverse effects; D012717:Sesquiterpenes / Q000009:adverse effects
chemical_list: D000447:Aldehydes; D000485:Allergens; D053138:Cyclohexenes; D003517:Cyclopentanes; D045792:Norisoprenoids; D000439:Pentanols; D010476:Perfume; D010938:Plant Oils; D020005:Propanols; D012717:Sesquiterpenes; C509149:ebanol; C494862:alpha-isomethylionone; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde; C020722:cinnamyl alcohol; C076763:sandalwood oil