Diphtheria tetanus pertussis poliomyelitis vaccination and reported atopic disorders in 8-12-year-old children.
BACKGROUND
Evidence for the relationship between the diphtheria tetanus pertussis (DTP) vaccination and atopic disorders is inconclusive, because the available studies that constitute the evidence are liable to confounding by indication.


OBJECTIVE
To assess the relationship between diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination (DTP-IPV) in the first year of life and reported atopic disorders at primary school age.


METHODS
1875 children attending Orthodox Reformed (Protestant) primary schools in the Netherlands returned questionnaires with data on vaccination status, atopic symptoms and lifetime atopic disorders (asthma, hay fever, eczema and food allergy), and possible confounders.


RESULTS
The adjusted odds ratio of any atopic disorder (vaccinated/unvaccinated) was 1.00 (CI95%: 0.80-1.24). For asthma, hay fever, eczema and food allergy the results were respectively: 1.04 (CI95%: 0.76-1.42), 0.79 (CI95%: 0.55-1.12), 0.87 (CI95%: 0.66-1.14) and 1.13 (CI95%: 0.71-1.81).


CONCLUSIONS
The DTP-IPV vaccination was not related to reported atopic disorders at primary school age.
Bernsen
Roos M D
RM
Department of General Practice, Room FF 305, Erasmus MC-University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands.
de Jongste
Johan C
JC
Koes
Bart W
BW
Aardoom
Harry A
HA
van der Wouden
Johannes C
JC
D002648:Child; D003430:Cross-Sectional Studies; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology*; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects*; D017778:Vaccines, Combined / Q000009:adverse effects
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined