title: The importance of water quality and haemodialysis fluid composition.
abstract: Treatment of renal failure by haemodialysis uses dialysis fluid to facilitate the normalization of electrolyte and acid base abnormalities and the removal of low molecular weight uraemic compounds present in the plasma such as urea. The dialysis fluid is a continuously produced blend of treated tap water and a concentrated solution containing electrolytes, buffer, and glucose. The water used originates as drinking water but undergoes additional treatment. Recent surveys have indicated that the chemical and microbiological content of such water frequently fails to meet the requirements of established standards, and its bacterial content arising from the presence of a biofilm in the water distribution network or the hydraulic circuit of the dialysis machine is a contributory factor to the chronic inflammatory state in patients undergoing regular dialysis. The composition of the dialysis fluid plays an important role in the modulation of complications associated with end-stage renal disease, as well as those associated with the treatment itself. The avoidance of complications arising from water contaminants requires a constant and vigorous attention to water quality, whilst with the composition of electrolytes and buffer there is a trend towards greater individualization to provide a high degree of treatment tolerance.
authors.affiliation: School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. nicholas.hoenich@ncl.ac.uk
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Hoenich
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
authors.forename: Robert
authors.initials: R
authors.lastname: Levin
mesh_terms: D018441:Biofilms / Q000254:growth & development; D004866:Equipment Contamination / Q000517:prevention & control*; D015312:Hemodialysis Solutions / Q000592:standards; D006801:Humans; D011786:Quality Control; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000628:therapy; D018508:Water Purification
chemical_list: D015312:Hemodialysis Solutions