Stop Flow in abdominal and pelvic cancer relapses.
To determinate MTD, DLT and safe doses for phase II study, a dose finding study with Mitomycin and Adriamycin Stop-Flow administration was carried out. A phase II study focused on resectability of pelvic colorectal relapses is in progress. From November 1995, 84 pts, 52 male and 32 female (94 treatments), with advanced not resectable abdominal (14 pts) or pelvic (70 pts) relapses, and resistant to previous systemic chemotherapy, were enrolled in the study. 46 pts entered the phase I-early phase II study, while subsequently 38 pts were recruited in ongoing phase II study. Safe dose were: MMC 20 mg/mq and ADM 75 mg/mq. The phase II study focused on colorectal relapses registered very promising responses: 90% pain control, 1 pCR and 26 PR / 63 (OR 43%), 8 NC (13%) 9/27 responder patients (33%) obtained a complete resectability of colorectal relapses. Stop-Flow is a safe and feasible technique very useful as a palliation treatment.
Iaffaioli
Rosario Vincenzo
RV
Med Onc B INT Naples, Cagliari University, Italy. roberta.formato@tin.it
Facchini
Gaetano
G
Tortoriello
Anna
A
Crovella
Feliciano
F
Romano
Giovannni
G
Formato
Roberta
R
Santangelo
Michele
M
Barletta
Emiddio
E
Fiore
Francesco
F
Iaccarino
Vittorio
V
Memoli
Bruno
B
D'Angelo
Roberto
R
Pilati
Pier Luigi
PL
Rossi
Riccardo
R
Guadagni
Stefano
S
Deraco
Marcello
M
Pignata
Sandro
S
Daniele
Bruno
B
Rosati
Gerardo
G
Massidda
Bruno
B
Mantovani
Giovanni
G
Di Salvo
Enrico
E
Marzano
Nicola
N
Memeo
Vincenzo
V
Parisi
Valerio
V
Mallarini
Giorgio
G
Colucci
Giuseppe
G
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D010386:Pelvic Neoplasms / Q000628:therapy*; D012008:Recurrence; D016896:Treatment Outcome
D016685:Mitomycin; D004317:Doxorubicin