Stimulation on DNA triplet repeat strand slippage synthesis by the designed spirocycles.
The designed simpler chiral spirocyclic helical compounds that mimic the molecular architecture of the DNA bulge binder NCSi-gb have been prepared. It has been found that the synthesized spirocyclic compounds have strong stimulation effect on DNA slippage synthesis. Their stimulation activities on DNA strand slippage suggest that they may bind to or induce the formation of a non Watson-Crick structure during in vitro replication of DNA triplet repeats.
Xi
Zhen
Z
State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology, Nankai University, Tianjin 300071, China. zhenxi@nankai.edu.cn
Ouyang
Di
D
Mu
Hong-Tao
HT
D000586:Amination; D002241:Carbohydrates / Q000737:chemistry; D003500:Cyclization; D004247:DNA / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D004261:DNA Replication / Q000187:drug effects*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D013237:Stereoisomerism; D013268:Stimulation, Chemical; D018911:Trinucleotide Repeats / Q000235:genetics*
D002241:Carbohydrates; D004247:DNA; D004259:DNA-Directed DNA Polymerase