title: Stress-induced plasticity of monoamine axons.
abstract: Central serotonergic (5-HT) and noradrenergic (NA) neurons, which innervate the same regions of the brain, are known to play a crucial role in emotion and mood. These monoamine neurons have a great capacity to alter axonal morphology in response to repeated stress. The morphological responses of 5-HT and NA axons to repeated stress are different, and they sometimes even demonstrate opposite responses (namely, either sprouting or degeneration). Moreover, a morphological interaction also occurs between 5-HT and NA axons during axonal regeneration. This review describes the differential features of axonal plasticity of 5-HT and NA neurons in relation to stress, and discusses the possible roles that the morphological plasticity of 5-HT and NA axons may play in the pathophysiology of depression.
authors.affiliation: Department of Neuroscience, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000588:Amines / Q000737:chemistry*; D000928:Antidepressive Agents / Q000494:pharmacology; D001369:Axons / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003866:Depressive Disorder / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D009410:Nerve Degeneration / Q000378:metabolism; D009416:Nerve Regeneration; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
chemical_list: D000588:Amines; D000928:Antidepressive Agents; D011941:Receptors, Adrenergic; D012701:Serotonin; D009638:Norepinephrine