Asymmetric hydrogenation of imines and olefins using phosphine-oxazoline iridium complexes as catalysts.
Herein we describe the synthesis of a new class of chiral phosphine-oxazolines and their application as ligands in iridium-catalyzed hydrogenations. Mechanistic aspects of olefin hydrogenation with this class of iridium catalysts are discussed and a selectivity model to help rationalize the results obtained is also presented.
Trifonova
Anna
A
Department of Chemistry, Organic Chemistry, Uppsala University, Box 599, SE-75124, Uppsala, Sweden.
Diesen
Jarle S
JS
Andersson
Pher G
PG
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006836:Hydro-Lyases; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*
D000475:Alkenes; D007097:Imines; D008024:Ligands; D010080:Oxazoles; D010720:Phosphines; D007495:Iridium; D006836:Hydro-Lyases