title: Serum 17-alpha-hydroxyprogesterone and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs with suspected hyperadrenocorticism.
abstract: OBJECTIVE
  To assess serum 17-alpha-hydroxyprogesterone (17OHP) and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs being screened for hyperadrenocorticism.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  16 clinically normal dogs, 35 dogs with nonadrenal neoplasia, and 127 dogs with suspected hyperadrenocorticism.
  
  
  METHODS
  ACTH stimulation tests were performed in all dogs. Baseline serum cortisol and corticosterone concentrations were measured in the healthy dogs; baseline serum cortisol concentration and ACTH-stimulated cortisol, corticosterone, and 17OHP concentrations were measured in all dogs. Endogenous plasma ACTH concentration was also measured before administration of ACTH in dogs with neoplasia.
  
  
  RESULTS
  In 35 dogs with neoplasia, 31.4% had high serum 17OHP concentration and 22.9% had high serum corticosterone concentration. Of the 127 dogs with suspected hyperadrenocorticism, 59 (46.5%) had high ACTH-stimulated cortisol concentrations; of those, 42 of 59 (71.2%) and 32 of 53 (60.4%) had high serum 17OHP and corticosterone concentrations, respectively. Of dogs with serum cortisol concentration within reference range after ACTH administration, 9 of 68 (13.2%) and 7 of 67 (10.4%) had high serum 17OHP and corticosterone concentrations, respectively. In the dogs with neoplasia and dogs suspected of having hyperadrenocorticism, post-ACTH serum hormone concentrations were significantly correlated.
  
  
  CONCLUSIONS
  Serum concentrations of 17OHP or corticosterone after administration of ACTH may be high in dogs with nonadrenal neoplasia and no evidence of hyperadrenocorticism. Changes in serum 17OHP or corticosterone concentrations after administration of ACTH are proportionate with changes in cortisol concentration.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA.
authors.forename: Ellen N
authors.initials: EN
authors.lastname: Behrend
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Kemppainen
authors.forename: A Lindsay
authors.initials: AL
authors.lastname: Boozer
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Whitley
authors.forename: Annette N
authors.initials: AN
authors.lastname: Smith
authors.forename: K Ann
authors.initials: KA
authors.lastname: Busch
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood*; D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D005260:Female; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone