Endoscopic CO2 laser surgery for early glottic cancer in patients who are candidates for radiotherapy: results of a prospective nonrandomized study.
BACKGROUND
Treatment of early glottic malignancies is controversial, particularly if postoperative endoscopy shows minimal/no residual disease.


METHODS
In a prospective nonrandomized study, we performed endoscopic laser surgery with curative intent in 59 patients with early glottic carcinoma presenting for radiotherapy after diagnosis elsewhere by random biopsy or cordal stripping. We analyzed outcomes and residual cancer in the specimen.


RESULTS
Clinical staging elsewhere did not correspond to (usually underestimated) the pathologic stage in 60.7%. In 22%, no tumor was identified on pathologic examination. After 35.3 months (mean), 93.2% were alive with no evidence of disease. Local control was achieved in 98.3% of the patients, and 13.5% of the patients required radiotherapy. The larynx was conserved in 98.3%.


CONCLUSIONS
Biopsy/stripping are best abandoned for persistent glottic lesions. A single laser endoscopic procedure provides reliable staging and definitive treatment in most cases using fewer resources. Biopsied patients presenting for treatment should be offered laser surgery as an alternative to radiotherapy.
Ansarin
Mohssen
M
Division of Head and Neck Surgery, European Institute of Oncology, Via Ripamonti, 435, 20141 Milano, Italy.
Zabrodsky
Michal
M
Bianchi
Livia
L
Renne
Giuseppe
G
Tosoni
Antonella
A
Calabrese
Luca
L
Tredici
Paola
P
Jereczek-Fossa
Barbara A
BA
Orecchia
Roberto
R
Chiesa
Fausto
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D004724:Endoscopy; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies