title: [Cardiovascular prevention and large clinical trials].
abstract: Large clinical trials of the three last decades have transformed the therapeutic landscape in depth. After putting into question the multi-factorial approach and simplistic models such as that of isotropy, clinical trials have shown to which extent some drugs are an efficacious way of reducing the burden of premature cardiovascular events and of prolonging life. The optimal use of the results from large clinical trials requires a permanent updating process, which is not realistic for the non-specialist physician: dedicated and fitted interfacing tools have to be developed. Practitioners must be trained to use these new concepts and tools.
authors.affiliation: Service de pharmacologie clinique - EA 3736, centre d'investigation clinique - CIC de Lyon, hôpital Louis Pradel, 69677 Bron. francois.gueyffier@chu-lyon.fr
authors.forename: François
authors.initials: F
authors.lastname: Gueyffier
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D012307:Risk Factors