Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
A new series of 3-benzyl-2-substituted quinoxalines have been synthesized by means of microwave enhancement of nucleophilic substitution reaction involving the corresponding 2-chloroquinoxaline analogs and substituted amines or hydrazine. The synthesized compounds were evaluated for their monoamine oxidase A and B inhibitory activity by determination of their IC(50). All the newly synthesized compounds showed more selective inhibitory activity toward MAO-A than MAO-B. In addition, the acute toxicity of the synthesized compounds was determined. This work may be a fruitful matrix of the synthesis of a new series of novel MAO-A inhibitors with good safety margins.
Hassan
Seham Y
SY
Department of Chemistry, Faculty of Science, University of Alexandria, Alexandria 21521, Egypt.
Khattab
Sherine N
SN
Bekhit
Adnan A
AA
Amer
Adel
A
D000818:Animals; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D008995:Monoamine Oxidase / Q000737:chemistry* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D008996:Monoamine Oxidase Inhibitors; D011810:Quinoxalines; D008995:Monoamine Oxidase