Bilateral thalamic lesions affect recollection- and familiarity-based recognition memory judgments.
The contribution of the thalamus to different forms of explicit memory is poorly understood. In the current study, explicit memory performance was examined in a 40-year-old male (RG) with bilateral anterior and medial thalamic lesions. Standardized tests indicated that the patient exhibited more severe recall than recognition deficits and his performance was generally worse for verbal compared to nonverbal memory. Recognition memory tests using the remember-know (R/K) procedure and the confidence-based receiver operating characteristic (ROC) procedure were used to examine recollection- and familiarity-based recognition. These tests revealed that RG had deficits in recollection and smaller, but consistent deficits in familiarity. The results are in agreement with models indicating that the anteromedial thalamus is important for both recollection- and familiarity-based recognition memory.
Kishiyama
Mark M
MM
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94728-3190, USA. mmkishiyama@berkeley.edu
Yonelinas
Andrew P
AP
Kroll
Neal E A
NE
Lazzara
Michele M
MM
Nolan
Eric C
EC
Jones
Edward G
EG
Jagust
William J
WJ
D000328:Adult; D005145:Face; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D020766:Intracranial Embolism / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D011932:Reading; D021641:Recognition, Psychology / Q000502:physiology*; D020521:Stroke / Q000209:etiology / Q000473:pathology / Q000523:psychology*; D013788:Thalamus / Q000473:pathology*