Anaphase topsy-turvy: Cdk1 a securin, separase a CKI.
Chromosome segregation in mitosis and meiosis is triggered by activation of a large protease, separase. While it has been known for some time that the anaphase inhibitor securin regulates separase activity recent work shows that this is only half the story. In vertebrates Cdk1-dependent inhibition of separase represents a second, securin-independent branch of anaphase regulation. Furthermore, an unanticipated ability of separase to inhibit Cdk1 suggests additional, nonproteolytic functions of separase.
Stemmann
Olaf
O
Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany. stemmann@biochem.mpg.de
Gorr
Ingo H
IH
Boos
Dominik
D
D000705:Anaphase; D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D064247:Separase
D018797:Cell Cycle Proteins; D016203:CDC2 Protein Kinase; D010450:Endopeptidases; C577987:ESPL1 protein, human; D064247:Separase