Primer on molecular imaging technology.
A wide range of technologies is available for in vivo, ex vivo, and in vitro molecular and cellular imaging. This article focuses on three key in vivo imaging system instrumentation technologies used in the molecular imaging research described in this special issue of Eur J Nucl Med Mol Imaging: positron emission tomography, single-photon emission computed tomography, and bioluminescence imaging. For each modality, the basics of how it works, important performance parameters, and the state-of-the-art instrumentation are described. Comparisons and integration of multiple modalities are also discussed. The principles discussed in this article apply to both human and small animal imaging.
Levin
Craig S
CS
Division of Nuclear Medicine, Department of Radiology and Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, Room R354, Stanford, CA 94305-5344, USA. cslevin@stanford.edu
D000818:Animals; D001709:Biotechnology / Q000295:instrumentation / Q000379:methods / Q000639:trends; D006801:Humans; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D008967:Molecular Biology / Q000295:instrumentation / Q000379:methods; D015336:Molecular Probe Techniques / Q000295:instrumentation* / Q000639:trends; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D013673:Technology Assessment, Biomedical; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation* / Q000379:methods* / Q000639:trends