title: Small cell neuroendocrine carcinoma in the petrous apex.
abstract: With the exception of moderately differentiated neuroendocrine carcinoma of the larynx, neuroendocrine carcinomas are very rare head and neck malignancies. We report a case of a small cell neuroendocrine carcinoma in the petrous apex of the temporal bone. This unusual site for this tumour has not yet been reported in the literature. We confirmed the location and extent of the primary tumour by positron-emission tomography scan. The final histopathological diagnosis was of small cell carcinoma, and this was confirmed by immunohistochemistry. We treated this patient with surgery followed by radiotherapy and chemotherapy. After the treatment was completed there was subtotal remission of the tumour, with no distant metastases.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center, Zagreb, Croatia. dkovac@kbc-zagreb.hr
authors.forename: Lana
authors.initials: L
authors.lastname: Kovac
authors.forename: Mislav
authors.initials: M
authors.lastname: Gjurić
authors.forename: Srećko
authors.initials: S
authors.lastname: Branica
authors.forename: Krsto
authors.initials: K
authors.lastname: Dawidowsky
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
mesh_terms: D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013701:Temporal Bone / Q000473:pathology; D016896:Treatment Outcome