title: Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage.
abstract: The ability of engineered cerium oxide nanoparticles to confer radioprotection was examined. Human normal and tumor cells were treated with nanoceria and irradiated, and cell survival was measured. Treatment of normal cells conferred almost 99% protection from radiation-induced cell death, whereas the same concentration showed almost no protection of tumor cells. For the first time, nanoceria is shown to confer radioprotection to a normal human breast line but not to a human breast tumor line, MCF-7.
authors.affiliation: M. D. Anderson Cancer Center Orlando, Orlando Regional Healthcare, Orlando, FL 32806, USA. rtarnuzzer@cfl.rr.com
authors.forename: Roy W
authors.initials: RW
authors.lastname: Tarnuzzer
authors.forename: Jimmie
authors.initials: J
authors.lastname: Colon
authors.forename: Swanand
authors.initials: S
authors.lastname: Patil
authors.forename: Sudipta
authors.initials: S
authors.lastname: Seal
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001698:Biomedical Engineering / Q000379:methods; D001940:Breast / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000473:pathology*; D002563:Cerium / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods*; D011836:Radiation Tolerance / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D004304:Dosage Forms; D002563:Cerium; C030583:ceric oxide