title: No, it is not possible to be schizophrenic yet neuropsychologically normal.
abstract: Cognitive impairment is well documented in schizophrenia, though some reports have been interpreted to suggest that it is possible to have schizophrenia without neuropsychological impairment. The authors tested this by comparing the neuropsychological profiles of closely matched patients with schizophrenia and healthy comparison participants. Sixty-four patients with schizophrenia and 64 healthy comparison cases, matched to within 3 Full-Scale IQ points, were tested using the Wechsler Adult Intelligence Scale (3rd ed.; D. Wechsler, 1997b) and the Wechsler Memory Scale (3rd ed.; D. Wechsler, 1997c). Neuropsychological profiles for these groups were markedly different, with the group of patients with schizophrenia exhibiting performance deficits in memory and speeded visual processing but superior verbal comprehension and perceptual organization relative to the group of healthy comparison participants matched on Full-Scale IQ. Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness.
authors.affiliation: Maryland Psychiatric Research Center, University of Maryland School of Medicine, Department of Psychiatry, Baltimore, MD 21228-0747, and Mental Illness Research, Education, and Clinical Center, Veterans Affairs Capital Health Care Network, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Wilk
authors.forename: James M
authors.initials: JM
authors.lastname: Gold
authors.forename: Robert P
authors.initials: RP
authors.lastname: McMahon
authors.forename: Katherine
authors.initials: K
authors.lastname: Humber
authors.forename: Virginia N
authors.initials: VN
authors.lastname: Iannone
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014705:Verbal Behavior / Q000502:physiology; D014888:Wechsler Scales / Q000706:statistics & numerical data