title: Quantitative evaluation of acute mucosal reaction to interstitial brachytherapy using color histograms.
abstract: OBJECTIVE
  Color histograms of tongue photographs were used to make a quantitative evaluation of acute mucosal reaction to high-dose-rate fractionated interstitial brachytherapy.
  
  
  METHODS
  Six patients with oral cavity cancer were analyzed with two methods (color histogram and vinyl plate). Using a photograph of the tongue, we calculated the histogram of each pixel of 1mm(2) of the tongue surface. The results were compared with the physician's inspection and the radiation dose.
  
  
  RESULTS
  The histogram showed a difference between the reactive area (erythema and pseudomembranous mucositis [PM]) and the nonreactive area. The relationship between inspection and the histogram showed a good correlation, although the histogram tended to change earlier than the subjective judgment. The peak time was 12-13 days after delivery of the final fraction of brachytherapy. The minimum dose required to cause PM was 3.3-3.6Gy per fraction (total: 29.7-32.4Gy).
  
  
  CONCLUSIONS
  Our new method of using color histograms for quantitative evaluation is helpful in the analysis of the relationship between mucosal reaction and radiation dose. The minimum dose causing PM was considered to be about 30Gy per nine fractions.
authors.affiliation: Department of Radiology, Osaka National Hospital, Osaka, Japan. kyoshida@onh.go.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nose
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Tokuda
authors.forename: Soomi
authors.initials: S
authors.lastname: Choi
authors.forename: Takuya
authors.initials: T
authors.lastname: Hosoki
authors.forename: Masanori
authors.initials: M
authors.lastname: Mitomo
authors.forename: Osamu
authors.initials: O
authors.lastname: Inaba
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iida
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Okada
mesh_terms: D000208:Acute Disease; D001918:Brachytherapy / Q000009:adverse effects*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology / Q000473:pathology; D005720:Gamma Rays / Q000009:adverse effects; D006801:Humans; D009060:Mouth Floor / Q000473:pathology / Q000528:radiation effects; D009061:Mouth Mucosa / Q000473:pathology* / Q000528:radiation effects*; D009092:Mucous Membrane / Q000473:pathology / Q000528:radiation effects; D015588:Observer Variation; D010781:Photography; D013280:Stomatitis / Q000209:etiology* / Q000473:pathology*; D014062:Tongue Neoplasms / Q000532:radiotherapy