title: Genomics of the future: identification of quantitative trait loci in the mouse.
abstract: Positional cloning of quantitative trait loci in rodents is a common approach to identify genes involved in complex phenotypes, including genes important to human disease. However, cloning the causative genes has proved to be more difficult than determining their positions. New tools such as genomic sequence, clone libraries, and new genomic-based methods offer new approaches to identify these genes. Here we review how these new tools and approaches will improve our ability to discover the genes important in complex traits.
authors.affiliation: Genomics Institute, Wadsworth Center, Troy, New York 12180, USA. flaherty@wadsworth.org
authors.forename: Lorraine
authors.initials: L
authors.lastname: Flaherty
authors.forename: Bruce
authors.initials: B
authors.lastname: Herron
authors.forename: Derek
authors.initials: D
authors.lastname: Symula
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005544:Forecasting; D023281:Genomics / Q000379:methods* / Q000639:trends; D051379:Mice / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*