title: WBN/Kob-Ht rats spontaneously develop dermatitis under conventional conditions: another possible model for atopic dermatitis.
abstract: WBN/Kob-Ht rats (Ht-rats) raised under conventional conditions spontaneously developed dermatitis. In this study, we carried out histopathological analysis to elucidate the pathological features of the dermatitis in Ht-rats. We then tried to detect Staphylococcus species recovered from the skin lesions of Ht-rats. We also measured the serum levels of total IgE, IL-4 and IFN-gamma in these rats. The histopathological data indicated that inflammatory cells had infiltrated the skin lesions. Staphylococcus aureus was recovered from the skin lesions, and the serum levels of total IgE and IL-4 were elevated in Ht-rats with dermatitis. These results suggest that dermatitis in Ht-rats is similar to that in the DS-Nh mice, which has recently been proposed as an animal model for human atopic dermatitis.
authors.affiliation: Shionogi Discovery Research Laboratories, Shionogi Co., Ltd., Futaba-cho, Toyonaka, Osaka, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Asakawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hikita
authors.forename: Takaji
authors.initials: T
authors.lastname: Matsutani
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hirasawa
authors.forename: Akinori
authors.initials: A
authors.lastname: Arimura
authors.forename: Tsuneaki
authors.initials: T
authors.lastname: Sakata
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Horikawa
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D004195:Disease Models, Animal; D007073:Immunoglobulin E / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D051381:Rats; D011922:Rats, Mutant Strains; D012867:Skin / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma