Survivin: a protein with dual roles in mitosis and apoptosis.
Survivin is a fascinating little protein that acts as a component of the chromosomal passenger complex, which is essential for cell division, and as an inhibitor of apoptosis. With dual roles in promoting cell proliferation and preventing apoptosis, it is considered a protein that interfaces life and death. Interest in survivin has been fueled by its abundance in human cancers, where it has potential as a prognostic marker for cancer, and as a target for chemotherapy. Accordingly, since its discovery in 1997, publications on survivin have risen exponentially in basic and clinical fields alike. This review highlights the key advances in our understanding of the cellular function of this protein.
Wheatley
Sally P
SP
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom.
McNeish
Iain A
IA
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D001483:Base Sequence; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D015853:Cysteine Proteinase Inhibitors / Q000502:physiology; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy; D020033:Protein Isoforms; D012097:Repressor Proteins; D000077022:Survivin; D029867:Xenopus Proteins / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; C107489:BIRC5 protein, human; C117749:Birc5 protein, mouse; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; C506387:Cflar protein, mouse; D015853:Cysteine Proteinase Inhibitors; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D020033:Protein Isoforms; D012097:Repressor Proteins; D000077022:Survivin; D029867:Xenopus Proteins; C472712:birc5.2 protein, Xenopus