Possible precipitation of myoclonic seizures with oxcarbazepine.
Oxcarbazepine is an antiepileptic drug widely used to treat partial seizures in children and adults. We report two children who developed mycolonic seizures and had abnormal electroencephalograms when oxcarbazepine was introduced. Although it is possible that the emergence of myoclonic seizures and deterioration of the electroencephalograms were due to the natural course of the disorder, clinicians should be aware of the possible detrimental effects of oxcarbazepine in children with seizures.
Kaddurah
Ahmad K
AK
Hurley Center, Flint, MI, USA.
Holmes
Gregory L
GL
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009207:Myoclonus / Q000139:chemically induced*; D000078330:Oxcarbazepine; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid; D000078330:Oxcarbazepine