title: The role of preoperative prophylactic antibiotic administration in periapical endodontic surgery: a randomized, prospective double-blind placebo-controlled study.
abstract: OBJECTIVE
  To determine the value of clindamycin prophylaxis in the prevention of postoperative wound infections in patients undergoing endodontic surgery.
  
  
  METHODS
  This study included 256 patients undergoing endodontic surgery in a prospective double-blind placebo-controlled trial comparing oral administration of an oral placebo versus a preoperative 600 mg dose of clindamycin. After randomization the study medication was administered orally 1 h before surgery in a double-blind fashion. For a period of 4 weeks the postoperative course was observed according to clinical parameters of infection. Primary end-point was infection at the surgical site.
  
  
  RESULTS
  The mean age of the study population was 44.4 years (SD 11.4, range 18-82 years) with a sex distribution of 147 females (47.4%) and 109 males (42.6%). Mean age of the patients in the clindamycin group was 44.7 years (SD 12.0), and the mean age in the placebo group was 44.1 years (SD 10.8) (P = 0.49). In the clindamycin group, the mean duration of surgery was 32.3 min (SD 8.8) and in the placebo group the mean duration of surgery was 32.5 min (SD 8.4) (P = 0.89). Two infections [1.6%; 95 confidence interval (CI): 0.48-4.72] were identified in the clindamycin group and four (3.2%; 95 CI: 0.42-1.33) in the placebo group (P = 0.448).
  
  
  CONCLUSIONS
  No statistically significant difference was found between clindamycin prophylaxis and placebo with regard to the prevention of postoperative infection in endodontic surgical procedures.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Academic Medical Centre Amsterdam and Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam, The Netherlands. j.a.lindeboom@amc.uva.nl
authors.forename: J A H
authors.initials: JA
authors.lastname: Lindeboom
authors.forename: J W H
authors.initials: JW
authors.lastname: Frenken
authors.forename: P
authors.initials: P
authors.lastname: Valkenburg
authors.forename: H P
authors.initials: HP
authors.lastname: van den Akker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001047:Apicoectomy; D002981:Clindamycin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008768:Methylmethacrylates / Q000627:therapeutic use; D008875:Middle Aged; D010485:Periapical Periodontitis / Q000601:surgery*; D010919:Placebos; D011300:Preoperative Care; D011446:Prospective Studies; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors; D015035:Zinc Oxide-Eugenol Cement / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D008768:Methylmethacrylates; D010919:Placebos; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; D002981:Clindamycin; C031667:IRM cement