title: Transcriptional regulation of mesendoderm formation in Xenopus.
abstract: Mesoderm and endoderm formation in Xenopus involves the coordinated efforts of maternally and zygotically expressed transcription factors together with growth factor signalling, including members of the TGFbeta and wnt families. In this review we discuss our current state of knowledge of these pathways, and describe in more detail some of the transcription factor-DNA interactions that are involved in mesendoderm formation.
authors.affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. fcw27@cam.ac.uk
authors.forename: Fiona C
authors.initials: FC
authors.lastname: Wardle
authors.forename: James C
authors.initials: JC
authors.lastname: Smith
mesh_terms: D000818:Animals; D019521:Body Patterning; D004707:Endoderm / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism; D029867:Xenopus Proteins / Q000378:metabolism
chemical_list: D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins