title: [Functional status of haemostasis system in patients with visceral leishmaniasis].
abstract: During the last decades in Georgia was observed significant increase of cases of visceral leishmaniasis and fight against this disease became important problem as far as the management of this disease is rather problematic. According to references and our clinical experience patients with visceral leishmaniasis are predisposed to bleeding. The objective of our study was the assessment of functional status of hemostasis related to the degree of clinical severity. We have studied platelet count, activated partial thromboplastin time (APTT), prothrombin time, thrombin time, plasma concentration of fibrinogen, the soluble fibrin-monomeric complexes (SFMC), fibrinogen/fibrin degradation products (D-dimer) and anticoagulant protein C. Haemostatic functional tests were studied in 45 patients with visceral leishmaniasis before and after treatment (with 20-25 day intervals). Before treatment the reduction of platelet count was observed in 95%. Prolonged APTT and prothrombin time was found in severe forms of the disease. Thrombin time prolonged in 45.7%, SFMC level was increased in 80% (p=0.003) and D-dimer level in 95.6% (p=0.023). Protein C was in normal value in 73%. The results indicate that leishmania infection affects primary haemostasis, coagulation and fibrinolysis and these alterations are related to the severity of clinical symptoms. Investigation of SFMC and D-dimer showed that in case of visceral leishmaniasis activation of intravascular coagulation takes place, particularly during the severe forms of the disease, study of these markers is of the diagnostic and prognostic importance and the treatment at an early stage of infection may potentially avoid the possibility of developing an uncompensated DIC.
authors.forename: M L
authors.initials: ML
authors.lastname: Lomtadze
authors.forename: M A
authors.initials: MA
authors.lastname: Khochava
authors.forename: I A
authors.initials: IA
authors.lastname: Shalamberidze
authors.forename: M A
authors.initials: MA
authors.lastname: Shilakadze
authors.forename: T G
authors.initials: TG
authors.lastname: Dzhokhtaberidze
mesh_terms: D000293:Adolescent; D000981:Antiprotozoal Agents / Q000009:adverse effects; D002648:Child; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000469:parasitology / Q000503:physiopathology*; D008536:Meglumine / Q000009:adverse effects; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000009:adverse effects; D011517:Prothrombin Time; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate