Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions.
[structure: see text] The binding affinities of a cholic-acid-based fluorescent neutral receptor toward dicarboxylate anions and amino acids have been investigated in a CH3OH/H2O system (1:1, 0.01 M HEPES buffer, pH = 7.4) by fluorescence titration experiments. The synthetic host bearing four convergent functionalities strongly binds glutamate via multiple hydrogen bonds with a binding constant of (5.57 +/- 0.88) x 10(6).
Liu
Shun-Ying
SY
Department of Chemistry, Wuhan University, Hubei, China.
Fang
Lei
L
He
Yong-Bing
YB
Chan
Wing-Hong
WH
Yeung
Kai-Tai
KT
Cheng
Yuen-Kit
YK
Yang
Rong-Hua
RH
D024342:Amino Acids, Acidic / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D001665:Binding Sites; D015374:Biosensing Techniques / Q000379:methods*; D002793:Cholic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D005453:Fluorescence; D005971:Glutamates / Q000737:chemistry; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D014867:Water / Q000737:chemistry
D024342:Amino Acids, Acidic; D000838:Anions; D002793:Cholic Acids; D003998:Dicarboxylic Acids; D005971:Glutamates; D014867:Water