title: Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis.
abstract: Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. However, the serum concentration of Klebs von den Lungen (KL)-6 remained high. Although the mechanisms of lung injury by MTX have not been well defined, serial measurements of serum SPD might be useful for the clinical evaluation of drug-induced acute lung injury.
authors.affiliation: Division of Rheumatic Diseases, Tokyo Metropolitan Bokutoh Hospital, Koutohbashi, Sumida-ku, Tokyo, Japan. kevmed1@excite.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Usui
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Fujiki
authors.forename: F
authors.initials: F
authors.lastname: Yakusiji
authors.forename: J
authors.initials: J
authors.lastname: Tomiyama
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: H
authors.initials: H
authors.lastname: Ilzuka
authors.forename: Y
authors.initials: Y
authors.lastname: Kuga
mesh_terms: D000208:Acute Disease; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D008727:Methotrexate