Evidence of resilience: neuroimaging in former prisoners of war.
In this study, single voxel proton magnetic resonance spectroscopic imaging ((1)H-MRS) and volumetric analysis of hippocampal magnetic resonance imaging (MRI) images were used to determine if any differences in hippocampal biochemistry or volume were present between former prisoners of war (POWs) with and without posttraumatic stress disorder (PTSD) and control subjects matched for age and education. This study did not find lower hippocampal concentrations of N-acetylaspartate (NAA), smaller hippocampal volumes, or more impaired memory function in older veterans with PTSD compared with a group matched for traumatic experience or a nontraumatized control group.
Freeman
Thomas
T
Mental Health Service, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. THOMAS.FREEMAN@MED.VA.GOV
Kimbrell
Tim
T
Booe
Leroy
L
Myers
Michael
M
Cardwell
David
D
Lindquist
Diana M
DM
Hart
John
J
Komoroski
Richard A
RA
D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D003710:Demography; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008568:Memory; D011329:Prisoners / Q000523:psychology*; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism* / Q000523:psychology*; D014857:Warfare
D001224:Aspartic Acid; C000179:N-acetylaspartate