title: [Successful use of levosimendan in a patient with cardiogenic shock complicating acute myocardial infarction].
abstract: Levosimendan is a new inodilator that improves cardiac contractility by sensitizing troponin C to calcium. This drug has proved to be effective in treating advanced congestive heart failure but has not been evaluated in cardiogenic shock. We present the case of a 54-year-old male patient treated successfully with levosimendan for cardiogenic shock following acute myocardial infarction. Treatment with dobulamine. revascularisation and itra-aortic balloon conterpulsation had first failed to improve his hemodynamic variables. Levosimendan induced a steady decline of increased pulmonary capillary wedge pressure, followed by an increase in cardiac index and mixed venous oxygen saturation. Left ventricular ejection fraction improved from 25% to 47%. Infusion of levosimendan can be used in cardiogenic shock without side effects and to improve hemodynamics and left ventricular function.
authors.affiliation: Service d'anesthésie réanimeation, Hôpital militaire principal d'instruction de Tunis.
authors.forename: Ferjani
authors.initials: F
authors.lastname: Mustapha
authors.forename: Hamdi
authors.initials: H
authors.lastname: Moufida
authors.forename: Barakette
authors.initials: B
authors.lastname: Nedia
authors.forename: Lebbi
authors.initials: L
authors.lastname: Anis
authors.forename: Labbene
authors.initials: L
authors.lastname: Iheb
authors.forename: Haouala
authors.initials: H
authors.lastname: Habib
mesh_terms: D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006801:Humans; D006835:Hydrazones / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy*; D011724:Pyridazines / Q000627:therapeutic use*; D012770:Shock, Cardiogenic / Q000188:drug therapy* / Q000209:etiology*; D000077464:Simendan; D013318:Stroke Volume; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D000077464:Simendan