title: Mycophenolic Acid Production by Penicillium brevicompactum on Solid Media.
abstract: When grown on Czapek-Dox agar, Penicillium brevicompactum produced mycophenolic acid after a vegetative mycelium had been formed and as aerial hyphae were developing. Nutrients were still plenteous in the agar when the synthesis began. If aerial hyphal development was prevented by placing a dialysis membrane over the growing fungus, no mycophenolic acid was produced. When the dialysis membrane was peeled back and, as a consequence, production of aerial hyphae began, mycophenolic acid biosynthesis was observed. We concluded that mycophenolic acid was produced only by P. brevicompactum colonies that possessed an aerial mycelium.
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
authors.forename: C D
authors.initials: CD
authors.lastname: Bartman
authors.forename: D L
authors.initials: DL
authors.lastname: Doerfler
authors.forename: B A
authors.initials: BA
authors.lastname: Bird
authors.forename: A T
authors.initials: AT
authors.lastname: Remaley
authors.forename: J N
authors.initials: JN
authors.lastname: Peace
authors.forename: I M
authors.initials: IM
authors.lastname: Campbell