title: Split therapy: planned neck dissection followed by definitive radiotherapy for a T1, T2 pharyngolaryngeal primary cancer with operable N2, N3 nodal metastases--a prospective study.
abstract: BACKGROUND
  The management of patients with a small pharyngolaryngeal cancer (T1 and T2) with large nodal metastases is a subject of debate. We present data on the feasibility and outcome of treating these patients with surgery for the nodal metastases followed by definitive radiotherapy.
  
  
  METHODS
  Prospective study of 59 patients of small pharyngolaryngeal primary squamous carcinomas with operable (N2/N3) nodal metastasis treated with neck dissection followed by radiotherapy.
  
  
  RESULTS
  Complete nodal clearance was achieved in 54 (90%). The mean nodal size was 4 cm and extranodal extension was seen in 88% of patients in the study group. There were no significant postoperative complications. Median interval between surgery and radiotherapy was 23 days. Forty-nine patients (83%) started their RT within 6 weeks of surgery. With a median follow-up of 25 months, the disease free and overall survival was 54% and 60% (5 years).
  
  
  CONCLUSIONS
  The management of patients with a radiocurable pharyngolaryngeal primary with large nodes by this approach is a feasible option with adequate control and survival.
authors.affiliation: Department of Head and Neck Surgery, Tata Memorial Hospital, Mumbai, India. adcruz@vsnl.com
authors.forename: A K
authors.initials: AK
authors.lastname: D'cruz
authors.forename: G H
authors.initials: GH
authors.lastname: Pantvaidya
authors.forename: J P
authors.initials: JP
authors.lastname: Agarwal
authors.forename: D A
authors.initials: DA
authors.lastname: Chaukar
authors.forename: K A
authors.initials: KA
authors.lastname: Pathak
authors.forename: M S
authors.initials: MS
authors.lastname: Deshpande
authors.forename: P S
authors.initials: PS
authors.lastname: Pai
authors.forename: P
authors.initials: P
authors.lastname: Chaturvedi
authors.forename: K A
authors.initials: KA
authors.lastname: Dinshaw
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology*; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D037981:Neck Dissection; D009367:Neoplasm Staging; D010610:Pharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D011446:Prospective Studies; D016896:Treatment Outcome