title: [The question of surgical therapy for necrolytic migratory erythema, a cutaneous disease].
abstract: Necrolytic migratory erythema (NME) is a rare paraneoplastic dermatologic condition. Its underlying cause is usually a pancreatic islet cell tumour with marked glucagon secretion. The glucagonoma syndrome is characterised by pancreatic neuroendocrine neoplasm, NME, and diabetes mellitus. We present a case of glucagonoma syndrome in a 58-year-old woman with a history of recurrent cutaneous manifestations who was referred for surgical resection of a pancreatic neoplasm after the NME was finally diagnosed. We discuss diagnostic methods, differential diagnosis, and therapeutic management of this disease.
authors.affiliation: Klinik für Chirurgie und Chirurgische Onkologie, Charité - Universitätsmedizin Berlin, Campus Buch, Robert-Rössle-Klinik im Helios-Klinikum Berlin.
authors.forename: R
authors.initials: R
authors.lastname: Siegel
authors.forename: R
authors.initials: R
authors.lastname: Linse
authors.forename: B
authors.initials: B
authors.lastname: Rau
mesh_terms: D001706:Biopsy; D004890:Erythema / Q000209:etiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005935:Glucagonoma / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D010257:Paraneoplastic Syndromes; D011860:Radiography, Abdominal; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome