Increased taste intensity perception exhibited by patients with chronic back pain.
There is overlap between brain regions involved in taste and pain perception, and cortical injuries may lead to increases as well as decreases in sensitivity to taste. Recently it was shown that chronic back pain (CBP) is associated with a specific pattern of brain atrophy. Since CBP is characterized by increased sensitivity to pain, we reasoned that the sense of taste might also be enhanced in CBP. Detection and recognition thresholds were established for a sour taste and ratings of both suprathreshold taste intensity and pleasantness-unpleasantness perception were collected for sweet, sour, salty and bitter stimuli in 11 CBP patients and 11 matched control subjects. As a control, ratings were also collected for visual assessment of degree of grayness. There was no difference between CBP and control subjects for visual grayness rating. On the other hand, CBP patients in comparison to control subjects rated gustatory stimuli as significantly more intense but no more or less pleasant and showed a trend towards a lower detection threshold (i.e. increased sensitivity). The selectivity of the taste disturbance suggests interaction between pain and taste at specific brain sites and provides further evidence that CBP involves specific brain abnormalities.
Small
Dana M
DM
The John B Pierce Laboratory, Yale University, New Haven, CT, USA Department of Surgery, Yale University, New Haven, CT, USA Department of Psychology, Yale University, New Haven, CT, USA Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Anesthesia, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Neuroscience Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Apkarian
Vania A
VA
D000328:Adult; D001416:Back Pain / Q000503:physiopathology*; D002908:Chronic Disease; D004056:Differential Threshold; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013649:Taste; D013652:Taste Threshold; D014796:Visual Perception