title: [Acquired von Willebrand disease as an unusual manifestation of primary hypothyroidism: report of two cases].
abstract: Patients with hypothyroidism may have a minor increase in their bleeding tendency, causing easy bruising and menorrhagia. There is a positive correlation between factor VIII coagulant activity and thyroxin serum levels. Thus, patients with hypothyroidism have an acquired coagulation defect that is reversible with thyroxin supplementation. We report two sisters, aged 13 and 11 years, who met the criteria for von Willebrand's disease at the age of eight. Both sisters had a primary hypothyroidism due to Hashimoto's thyroiditis, diagnosed three years later. Thyroid hormone replacement normalized von Willebrand factor, factor VIII, and the bleeding diathesis disappeared. Acquired von Willebrand's disease is an unusual manifestation of hypothyroidism. However the possibility of hypothyroidism should be considered in patients presenting with von Willebrand disease.
authors.affiliation: Facultad de Medicina, Universidad de Concepción, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Concha
authors.forename: María Alejandra
authors.initials: MA
authors.lastname: Borzone
authors.forename: Marcelo
authors.initials: M
authors.lastname: Castillo
authors.forename: Alberto
authors.initials: A
authors.lastname: Rossle
authors.forename: Iván
authors.initials: I
authors.lastname: Quevedo
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D050031:Hashimoto Disease / Q000150:complications; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis; D013974:Thyroxine / Q000627:therapeutic use; D014842:von Willebrand Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor; D013974:Thyroxine