title: Etiology of fungaemia and catheter colonisation in Argentinean paediatric patients.
abstract: Yeast strains obtained from blood cultures and catheters from intensive care units (ICU) and hospitalised oncology paediatrics were studied. Yeast were the first cause of catheter colonisation (51/627), and the third cause of bloodstream infection (44/6065). In catheter, the most frequent species were Candida albicans (34%), C. parapsilosis (27.7%) and C. tropicalis (15%). In blood, C. albicans (40.8%), C. parapsilosis (26.6%), C. tropicalis (15%). Malassezia furfur and Malassezia sympodialis were isolated from catheters from ICU patients. All isolates were susceptible to amphotericin B, 88.8% to itraconazole and 91.9% to fluconazole. Candida albicans and C. tropicalis strains resistant to fluconazole and itraconazol were detected. These results reveal a change in the predominant role of C. albicans as cause of candidemia in hospitalised children and the emergence of antifungal resistant species. These variations emphasise the importance of performing a permanent surveillance to observe and assess them.
authors.affiliation: Departamento Micología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Resistencia, Chile.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Giusiano
authors.forename: Magdalena
authors.initials: M
authors.lastname: Mangiaterra
authors.forename: Viviana García
authors.initials: VG
authors.lastname: Saito
authors.forename: Florencia
authors.initials: F
authors.lastname: Rojas
authors.forename: Verónica
authors.initials: V
authors.lastname: Gómez
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Díaz
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001118:Argentina / Q000453:epidemiology; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology; D016469:Fungemia / Q000453:epidemiology* / Q000382:microbiology; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D015278:Intensive Care Units, Pediatric; D017964:Itraconazole / Q000494:pharmacology; D008290:Malassezia / Q000187:drug effects / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole