Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major.
Serum non-transferrin-bound iron (NTBI) levels assessed at arbitrary time points during transfusion cycles may not be representative if NTBI is undergoing significant changes during transfusion cycles. In 15 patients with beta-thalassemia major (age: 21 +/- 6 years, liver iron concentration: 2200 +/- 1200 microg/g-liver), NTBI and other hematologic parameters (transferrin saturation, transferrin receptor) were measured weekly. The largest variation of NTBI levels between individual patients was observed at midcycle. For long-term monitoring of NTBI levels, a particular time point relative to the last blood transfusion should be selected for blood drawing.
Grosse
Regine
R
University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology/Oncology, Martinistr. 52, Hamburg D-20246, Germany. regine_grosse@web.de
Lund
Ulrike
U
Caruso
Vincenzo
V
Fischer
Roland
R
Janka
Gritta E
GE
Magnano
Carmelo
C
Engelhardt
Rainer
R
Dürken
Matthias
M
Nielsen
Peter
P
D000293:Adolescent; D000328:Adult; D001800:Blood Specimen Collection; D001803:Blood Transfusion; D015913:Chelation Therapy; D003131:Combined Modality Therapy; D003676:Deferoxamine / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D007501:Iron / Q000097:blood*; D007502:Iron Chelating Agents / Q000627:therapeutic use; D008099:Liver / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D011446:Prospective Studies; D011990:Receptors, Transferrin / Q000032:analysis; D015203:Reproducibility of Results; D013997:Time Factors; D014168:Transferrin / Q000032:analysis; D017086:beta-Thalassemia / Q000097:blood / Q000188:drug therapy / Q000628:therapy*
D007502:Iron Chelating Agents; D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron; D003676:Deferoxamine