title: [Analysis of drug resistance spectrum and its mechanism in 1017 clinical bacterial isolates].
abstract: OBJECTIVE
  To investigate the drug susceptibility of the clinical bacterial isolates to provide evidence for more adequate use of antibiotics.
  
  
  METHODS
  Altogether 1017 clinical bacterial isolates were identified by BD Phoenix and tested for resistance against antimicrobial agents by K-B method. WHONET5 was applied for the analysis.
  
  
  RESULTS
  The most frequent bacteria detected included P. aeruginosa (19.37%), coagulase-negative Staphylococci (CNS, 17.70%), E. coli (13.27%), S. aureu (SA, 12.09%), E. faecalis (11.8%), and K. pneumoniae (7.57%). In gram-negative isolates, the susceptibility rate of imipenem was 81.5%, and that of ceftazidime was above 70%. The incidences of E.coli and K. pneumoniae isolates producing extended spectrum beta-lactamase (ESBLs) were 34.8% and 45.5% respectively. In gram-positive isolates, the susceptibility rates of vancomycin and Teicoplanin were 98.8% and 100.0% respectively, and those of furazolidone, imipenem, amikacin, piperacillin/ tazobactam were above 70%. The oxacillin resistant rates of CNS and SA were 78.2% and 46.8%.
  
  
  CONCLUSIONS
  The 1017 clinical bacterial isolates are characterized by high ratio of ESBL production and oxacillin resistance, suggesting the importance of adequate use of antimicrobial agents and effective control measures for reducing the drug resistance and preventing the spread of multi drug- resistant bacteria.
authors.affiliation: Clinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Sui-na
authors.initials: SN
authors.lastname: Geng
authors.forename: Yong-yu
authors.initials: YY
authors.lastname: Rui
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Cheng-hui
authors.initials: CH
authors.lastname: Mou
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem; D002442:Ceftazidime; D001618:beta-Lactamases; D010068:Oxacillin