title: Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating.
abstract: A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedländer condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Cheng-Sheng
authors.initials: CS
authors.lastname: Jia
authors.forename: Ze
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Guan-Wu
authors.initials: GW
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001190:Arylsulfonates / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry*; D006358:Hot Temperature; D007659:Ketones / Q000737:chemistry; D008872:Microwaves; D011804:Quinolines / Q000138:chemical synthesis*; D014050:Toluene / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001190:Arylsulfonates; D001557:Benzenesulfonates; D007659:Ketones; D011804:Quinolines; D014050:Toluene; C029501:4-toluenesulfonic acid