title: [Capillary electrophoretic enantioseparation of arylglycine amides with highly sulfated beta-cyclodextrin as chiral selector].
abstract: Enantiomers of nine arylglycine amides synthesized were successfully separated by capillary electrophoresis (CE) using highly sulfated beta-cyclodextrin (HS-beta-CD) as a chiral selector. Baseline enantioseparation of the analytes was obtained within 6 min at neutral pH but not the commonly used acidic condition. HS-beta-CD content, buffer type and concentration, and non-chiral additive were studied and optimized for high resolution and fast speed. A reproducible running buffer system composed of 15 g/L HS-beta-CD, 0 or 10% (volume fraction) methanol and 20 mmol/L 3-(N-morpholino) propane sulfonic acid at pH 6.5 was obtained. The D-enantiomer always migrated ahead of the L-enantiomer for all the 9 pairs of arylglycine amides. The migration order was found to be dependent on the structure of the solutes.
authors.affiliation: Center for Molecular Science, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Shuang-Jun
authors.initials: SJ
authors.lastname: Lin
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Qi
authors.forename: Mei-Xiang
authors.initials: MX
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000295:instrumentation* / Q000379:methods*; D005998:Glycine / Q000031:analogs & derivatives*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000577:Amides; D047392:beta-Cyclodextrins; C031215:betadex; D005998:Glycine