A case of atypical hemolytic uremic syndrome with a transient decrease in complement factor H.
We report a case of sporadic atypical hemolytic uremic syndrome (HUS) with a transient decrease in complement factor H. Referred for hemolysis and azotemia without diarrhea prodrome, this 31-month-old boy showed a decreased complement 3 (C3) and complement factor H (FH) level. However, the factor H gene (HF1) mutation was missing. After the hemolysis was controlled with plasma infusion, the C3 and FH levels recovered. The patient's renal function fully recovered and remained normal, and there was no recurrence of the HUS.
Hahn
Hyewon
H
Department of Pediatrics, Eulji University School of Medicine, Daejeon, Korea. petercat67@empal.com
Um
Eun Young
EY
Park
Young Seo
YS
Cheong
Hae Il
HI
D002675:Child, Preschool; D017242:Complement Factor H / Q000032:analysis*; D006463:Hemolytic-Uremic Syndrome / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008297:Male
D017242:Complement Factor H