Determination of solute lipophilicity by reversed-phase high-performance liquid chromatography (RP-HPLC).
Lipophilicity was evaluated by the high-throughput RP-HPLC method. A set of 40 solutes with well-defined solvatochromic parameters were selected in this study. The chromatographic results show that, under the conditions of study, the lipophilicity index log kw was highly correlated with the experimental log Poct.
Liu
Xiangli
X
Department of Molecular Analytical Chemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
Chuman
Hiroshi
H
D002851:Chromatography, High Pressure Liquid; D008055:Lipids / Q000737:chemistry; D000442:Octanols / Q000032:analysis; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water / Q000032:analysis
D008055:Lipids; D000442:Octanols; D014867:Water