title: The pap operon of avian pathogenic Escherichia coli strain O1:K1 is located on a novel pathogenicity island.
abstract: We have identified a 56-kb pathogenicity island (PAI) in avian pathogenic Escherichia coli strain O1:K1 (APEC-O1). This PAI, termed PAI I(APEC-O1), is integrated adjacent to the 3' end of the pheV tRNA gene. It carries putative virulence genes of APEC (pap operon), other E. coli genes (tia and ireA), and a 1.5-kb region unique to APEC-O1. The kps gene cluster required for the biosynthesis of polysialic acid capsule was mapped to a location immediately downstream of this PAI.
authors.affiliation: Iowa State University, 1802 Elwood Drive, VMRI #2, Ames, IA 50011, USA.
authors.forename: Subhashinie
authors.initials: S
authors.lastname: Kariyawasam
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Johnson
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Nolan
mesh_terms: D000818:Animals; D016667:Bacterial Capsules / Q000096:biosynthesis / Q000235:genetics; D002645:Chickens; D004926:Escherichia coli / Q000235:genetics* / Q000472:pathogenicity*; D010861:Fimbriae, Bacterial / Q000235:genetics*; D044404:Genomic Islands / Q000235:genetics*; D008969:Molecular Sequence Data; D012794:Sialic Acids / Q000096:biosynthesis / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics
chemical_list: D012794:Sialic Acids; D037521:Virulence Factors; C021319:polysialic acid