title: Maternal care is similar for rat pups subjected to birth hypoxia and for controls.
abstract: The rat model of global anoxia during cesarean section birth has been used extensively to investigate effects of birth hypoxia on central nervous system function. This study tested whether differential maternal care mediates central nervous system alterations in this model. Maternal care of mixed litters of pups born vaginally, by cesarean section or by cesarean section with anoxia, was assessed. Frequency and duration of licking and grooming by dams were similar for all birth groups. No group differences were observed in order of retrieval, when pups were displaced from the nest. The results indicate that altered central nervous system function in anoxic animals in this model are not due to differential maternal care, but may be mediated by other mechanisms such as direct hypoxic insult to neurons.
authors.affiliation: Douglas Hospital Research Center, Department of Psychiatry, McGill University Montreal, Quebec, Canada.
authors.forename: Yonina
authors.initials: Y
authors.lastname: Levine
authors.forename: Patricia
authors.initials: P
authors.lastname: Boksa
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D002585:Cesarean Section / Q000379:methods; D036861:Delivery, Obstetric / Q000145:classification / Q000379:methods; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology*; D008297:Male; D008425:Maternal Behavior / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors