title: Study of efficacy and safety of losartan (losar) in Asian Indian hypertensives.
abstract: Although there has been widespread dissemination of knowledge about hypertension, it remains poorly treated in most populations. Systemic hypertension is associated with increased risk for coronary artery disease, stroke, nephrosclerosis, peripheral vascular disease, etc. The treatment of hypertension includes non-pharmacological measures and the specific drug therapy. Losartan potassium is an orally active, non-peptide angiotensin II receptor antagonist. It is the first of this new class of drugs introduced for clinical use in hypertension. Data was obtained of 347 patients from 140 general physicians. The study revealed that losartan potassium is used in the treatment of mild to moderate hypertension with excellent to good response in 98.8% of the cases. Mild adverse reactions were reported in 5.8% of the cases. None of the adverse reactions were severe enough which required discontinuation of therapy or needed hospitalisation. Thus, the present postmarketing surveillance study confirms the safety and efficacy of losartan potassium in Indian population.
authors.affiliation: Lilavati & Bhatia Hospital, Mumbai.
authors.forename: Shashank R
authors.initials: SR
authors.lastname: Joshi
authors.forename: Shailaja
authors.initials: S
authors.lastname: Kale
authors.forename: Abraham
authors.initials: A
authors.lastname: Oomman
authors.forename: Romesh M
authors.initials: RM
authors.lastname: Joshi
authors.forename: Dimple
authors.initials: D
authors.lastname: Chopra
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007194:India; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011358:Product Surveillance, Postmarketing; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D019808:Losartan