Use of alendronate in the treatment of vitamin D intoxication in infants.
Vitamin D intoxication remains a challenging problem due to lack of an efficient treatment. Bisphosphonates, inhibitors of osteoclast-mediated bone resorption, however, have been proposed as a safe and effective alternative in the treatment of vitamin D intoxication. We present here two infants with vitamin D intoxication who were successfully treated with alendronate. We propose that oral alendronate is an alternative to intravenous bisphosphonates in the treatment of vitamin D intoxication in infancy.
Hatun
Sükrü
S
Division of Pediatric Endocrinology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Cizmecioğlu
Filiz
F
D019386:Alendronate / Q000627:therapeutic use*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D014807:Vitamin D / Q000633:toxicity*
D050071:Bone Density Conservation Agents; D014807:Vitamin D; D002118:Calcium; D019386:Alendronate