Insulin levels, physical activity, and urinary catecholamine excretion of obese and non-obese rhesus monkeys.
The hypothesis that spontaneous obesity in rhesus monkeys is associated with abnormalities in energy expenditure was tested. Obese (n=7) and non-obese (n=5) monkeys were described in terms of body size and composition, food intake, and physical activity. Additionally, the relationships among fasting and stimulated insulin levels in serum, C-peptide levels in serum and urine, and urinary catecholamines were examined. Obese animals had primarily abdominal deposition of excess body fat, as indicated by markedly elevated abdominal circumferences and skin-fold thicknesses. Food intake did not differ between groups. Physical activity was much lower in the obese group. Obese monkeys had markedly higher serum insulin and C-peptide levels in the fasted state and in response to an intravenous glucose challenge. Urinary excretion of C-peptide and catecholamines was measured during successive 2-day periods of ad libitum feeding, food deprivation, and refeeding in order to examine potential differences between groups in sympathoadrenal activity and their relationship to insulin secretion. C-peptide excretion was greater for obese and decreased for both groups during food deprivation. Urinary dopamine (DA), norepinephrine (NE), and epinephrine (E) levels were significantly greater for obese animals in all conditions. DA excretion was lowest during deprivation and E excretion was lowest during refeeding, whereas NE excretion was relatively unaffected by feeding condition. The overall patterns of C-peptide and catecholamine excretion were qualitatively similar for both groups, and there were no reliable differences between obese and non-obese in their responses to the feeding manipulation. The results suggest that hyperinsulinemia associated with obesity in rhesus monkeys is linked to increased catecholamine secretion and a resistance to catecholaminergic action.
Wolden-Hanson
T
T
Wisconsin Regional Primate Research Center, Neuroscience Training Program, Univ. of Wisconsin, Madison, WI 53715-1299, USA.
Davis
G A
GA
Baum
S T
ST
Kemnitz
J W
JW
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001835:Body Weight; D002096:C-Peptide / Q000097:blood / Q000652:urine; D002395:Catecholamines / Q000378:metabolism / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000652:urine; D004435:Eating; D004837:Epinephrine / Q000652:urine; D005247:Feeding Behavior; D005260:Female; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood*; D050356:Lipid Metabolism; D008253:Macaca mulatta; D008297:Male; D009043:Motor Activity; D009638:Norepinephrine / Q000652:urine; D009765:Obesity / Q000097:blood / Q000473:pathology / Q000652:urine*; D010805:Physical Conditioning, Animal; D013997:Time Factors
D002096:C-Peptide; D002395:Catecholamines; D007328:Insulin; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine