Phosphorylation of CARMA1: the link(er) to NF-kappaB activation.
Antigen receptor-induced NF-kappaB activation depends on receptor-proximal and -distal signaling events. Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB.
Rueda
Daniel
D
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
Thome
Margot
M
D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D053468:CARD Signaling Adaptor Proteins; D051528:Guanylate Kinases / Q000378:metabolism*; D007111:Immunity, Cellular / Q000502:physiology*; D016328:NF-kappa B / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D011946:Receptors, Antigen / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D015533:Transcriptional Activation / Q000276:immunology*
D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; C496467:Card11 protein, mouse; D016328:NF-kappa B; D011946:Receptors, Antigen; D011493:Protein Kinase C; D051528:Guanylate Kinases