title: White matter integrity of the whole brain is disrupted in first-episode schizophrenia.
abstract: Diffusion tensor imaging studies in schizophrenia have demonstrated lower diffusion anisotropy within white matter that provides information about brain white matter integrity. We have examined whether white matter is abnormal in first-episode schizophrenia by using diffusion tensor imaging. Twenty-one schizophrenic patients and healthy controls underwent diffusion tensor imaging scans that analyzed by using a rigorous voxel-based approach. We found that fractional anisotropy in white matter of the patients was lower than that in controls at the cerebral peduncle, frontal regions, inferior temporal gyrus, medial parietal lobes, hippocampal gyrus, insula, right anterior cingulum bundle and right corona radiata. These results suggested that white matter integrity of the whole brain was disrupted in early illness onset of schizophrenia.
authors.affiliation: The Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Hao
authors.forename: Zhening
authors.initials: Z
authors.lastname: Liu
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.forename: Gaolang
authors.initials: G
authors.lastname: Gong
authors.forename: Haihong
authors.initials: H
authors.lastname: Liu
authors.forename: Lihua
authors.initials: L
authors.lastname: Tan
authors.forename: Fan
authors.initials: F
authors.lastname: Kuang
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Yi
authors.forename: Zishu
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000473:pathology*