title: Dual pharmacotherapy and motivational interviewing for tobacco dependence among drug treatment patients.
abstract: This pilot study is the first to examine the feasibility and outcomes of dual pharmacotherapy for smoking cessation among drug treatment patients. The intervention consisted of 7 weeks of bupropion (300 mg), 12 weeks of nicotine gum, and 6 sessions of motivational interviewing. The trial was conducted among 28 patients recruited from 5 methadone clinics and employed a pretest-posttest design. At 6 months post quit date, 14% of participants met criteria for biochemically-verified abstinence. Among those still smoking, number of cigarettes smoked decreased significantly and most (88%) had made at least 1 serious quit attempt. Participation rates were excellent and no adverse effects on alcohol or illicit drug use were found. Although not a definitive test of the intervention, findings suggest that a multi-component approach to tobacco dependence is feasible and potentially effective in helping drug treatment patients achieve smoking cessation well beyond the end of treatment and that a large-scale randomized trial is warranted.
authors.affiliation: Department of Preventative Medicine and Public Health, 3901 Rainbow Boulevard, Mail Stop 1008, Kansas City, KS 66160, USA. krichter@kumc.edu
authors.forename: Kimber P
authors.initials: KP
authors.lastname: Richter
authors.forename: Robert M
authors.initials: RM
authors.lastname: McCool
authors.forename: Delwyn
authors.initials: D
authors.lastname: Catley
authors.forename: Matthew
authors.initials: M
authors.lastname: Hall
authors.forename: Jasjit S
authors.initials: JS
authors.lastname: Ahluwalia
mesh_terms: D000287:Administration, Topical; D016642:Bupropion / Q000627:therapeutic use*; D003376:Counseling; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007407:Interviews as Topic; D008605:Mental Health Services / Q000706:statistics & numerical data*; D008691:Methadone / Q000627:therapeutic use*; D009042:Motivation; D009294:Narcotics / Q000627:therapeutic use*; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use*; D010349:Patient Compliance / Q000706:statistics & numerical data; D010865:Pilot Projects; D016540:Smoking Cessation / Q000379:methods*; D011795:Surveys and Questionnaires; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D018765:Dopamine Uptake Inhibitors; D009294:Narcotics; D016642:Bupropion; D009538:Nicotine; D008691:Methadone