title: [Comparison CCR5de132 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in different groups of HIV-infected individuals].
abstract: The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 107), Tuvinians (n = 50), and HIV-infected individuals were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation.
authors.forename: S A
authors.initials: SA
authors.lastname: Apriatin
authors.forename: E R
authors.initials: ER
authors.lastname: Rakhmanaliev
authors.forename: I A
authors.initials: IA
authors.lastname: Nikolaeva
authors.forename: S V
authors.initials: SV
authors.lastname: Ruban
authors.forename: F G
authors.initials: FG
authors.lastname: Vazykhova
authors.forename: E A
authors.initials: EA
authors.lastname: Klimov
authors.forename: G E
authors.initials: GE
authors.lastname: Sulimova
authors.forename: I G
authors.initials: IG
authors.lastname: Sidorovich
mesh_terms: D000483:Alleles; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D006679:HIV Seropositivity / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000235:genetics*; D012426:Russia; D017384:Sequence Deletion; D044465:White People
chemical_list: D019713:Receptors, CCR5