The prevention of infection post-transplant: the role of prophylaxis, preemptive and empiric therapy.
The close linkage of infection with the nature and intensity of the transplant immunosuppressive program has led to the concept of the therapeutic prescription. This has two components: an immunosuppressive one to prevent or treat rejection and graft-versus-host disease and an antimicrobial one to make it safe. This review provides a conceptual framework to approach the risk and risk periods for infection in solid organ and hematopoietic stem cell transplant recipients as well as an approach to antimicrobial use in this population.
Marty
Francisco M
FM
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Rubin
Robert H
RH
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control; D003140:Communicable Disease Control; D006801:Humans; D009181:Mycoses / Q000517:prevention & control; D016377:Organ Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000517:prevention & control*; D011184:Postoperative Period; D014777:Virus Diseases / Q000517:prevention & control
D000890:Anti-Infective Agents