title: Increased expression of c-myc is associated with thymoma in rats infected with murine leukemia virus A8.
abstract: Infection of rats with Friend murine leukemia virus (Fr-MLV) clone A8 causes thymoma in all the animals within 7 weeks. The rapid induction of thymoma is associated with a unique enhancer structure in the U3 region of the A8-LTR. Our Southern blot analyses showed that the thymomas were oligo clonal. The A8-induced thymomas showed 3-to 11-fold overexpression of c-myc mRNA. These results suggest that provirus insertion into particular positions of the host genome is correlated with tumorigenesis after A8 infection and that up-regulation of c-myc plays an important role in the induction of thymoma.
authors.affiliation: Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo 192-8577, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hirano
authors.forename: Rihito
authors.initials: R
authors.lastname: Watanabe
authors.forename: Sayaka
authors.initials: S
authors.lastname: Takase-Yoden
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015139:Blotting, Southern; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011917:Rats, Inbred Lew; D012192:Retroviridae Infections / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013945:Thymoma / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism; D014412:Tumor Virus Infections / Q000378:metabolism*; D015854:Up-Regulation; D016662:Virus Integration
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger