title: Assessment of dynamic susceptibility contrast cerebral blood flow response to amphetamine challenge: a human pharmacological magnetic resonance imaging study at 1.5 and 4 T.
abstract: Pharmacological MRI (phMRI) techniques can be used to monitor the neurophysiological effects of central nervous system (CNS) active drugs. In this study, we investigated whether dynamic susceptibility contrast (DSC) perfusion imaging employing the use of superparamagnetic iron oxide nanoparticles (Resovist) could be used to measure hemodynamic response to d-amphetamine challenge in human subjects at both 1.5 and 4 T. Significant changes in cerebral blood flow (CBF) were found in focal regions associated with the nigrostriatal circuit and mesolimbic and mesocortical dopaminergic pathways. More significant CBF responses were found at higher field strength, mainly within striatal structures. The results from this study indicate that DSC perfusion imaging using Resovist can be used to assess the efficacy of CNS-active drugs and may play a role in the development of novel psychiatric therapies at the preclinical level.
authors.affiliation: Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia. Stephen.Rose@cmr.uq.edu.au
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Rose
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Janke
authors.forename: Mark W
authors.initials: MW
authors.lastname: Strudwick
authors.forename: Katie L
authors.initials: KL
authors.lastname: McMahon
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Chalk
authors.forename: Peter
authors.initials: P
authors.lastname: Snyder
authors.forename: Greig I
authors.initials: GI
authors.lastname: De zubicaray
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000493:pharmacokinetics*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D010087:Oxides
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D000661:Amphetamine; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide