[Isolation and identification of two new epimer from the mother liquid of megestrol acetate].
OBJECTIVE
To study the impurity in the drug megestrol acetate.


METHODS
Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis.


RESULTS
Two new epimers were isolated from the mother liquid of the drug megestrol acetate.


CONCLUSIONS
These new epimers were identified as 17alpha-acetoxy-2beta,6alpha-dimethylprega-4-ene-3,20-dione (1) and 17alpha-acetoxy-2alpha,6alpha-dimethylprega-4-ene-3,20-dione (2).
Yang
Zhong-Duo
ZD
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
Chen
Hua
H
Wang
You-Fu
YF
Lin
Li-Bo
LB
Li
Yuan-Chao
YC
D004340:Drug Contamination; D019290:Megestrol Acetate / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D011277:Pregnanediones / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D011277:Pregnanediones; D019290:Megestrol Acetate