title: [Clinical observation of toothpaste containing zanthoxylum nitidum extract on dental plaque and gingivitis].
abstract: OBJECTIVE
  To observe the clinical efficacy of drug toothpaste containing 2% Zanthoxylum Nitidum extract in reducing accumulation of dental plaque and occurrence of gingivitis in adults.
  
  
  METHODS
  Adopting double-blind, stratified and parallel design, the status of dental plaque and gingivitis in 200 healthy adults enrolled in the trial (100 in the treated group took the drug toothpaste to clean teeth, and 100 in the control group use common toothpaste instead) were assessed at before experiment, 3 months and 6 months after experiment.
  
  
  RESULTS
  At the end of the 3rd month and the 6th month, as compared with the control group, the L e-Silness Gingival Index (GI) in the treated group was decreased by 9.1% (P > 0.05) and 13.9 % (P< 0.5), in the same period, the Quigley-Hein(Turesky Modification) Plaque Index (PlI) decreased by 18.7% and 22.6% (P<0.05), respectively.
  
  
  CONCLUSIONS
  Toothpaste containing Zanthoxylum Nitidum extract can obviously decrease the incidence of dental plaque and enhance gingival health.
authors.affiliation: West China College of Stomatology, Sichuan University, Chengdu 610041.
authors.forename: Hu-chun
authors.initials: HC
authors.lastname: Wan
authors.forename: De-yu
authors.initials: DY
authors.lastname: Hu
authors.forename: Hong-chun
authors.initials: HC
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003773:Dental Plaque / Q000188:drug therapy*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D014100:Toothpastes / Q000737:chemistry*; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D014100:Toothpastes