title: Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatum.
abstract: Neurotrophic signaling is thought to be important for neuroplasticity in certain forebrain regions following psychostimulant exposure. In this study, we found that repeated administration of amphetamine (5 mg/kg, once daily, 5 days) to rats significantly increased tyrosine kinase-B receptor mRNA levels in the striatum, ventral bed nucleus, and piriform cortex. The most robust increase in tyrosine kinase-B expression occurred in dorsal aspects of the striatum, which also showed elevated levels after a single amphetamine injection. These findings indicate that changes in striatal tyrosine kinase-B signaling could play a role in neuroadaptations and behavioral changes induced by amphetamine treatment.
authors.affiliation: Department of Cellular and Molecular Pharmacology, Chicago Medical School/Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA. Gloria.Meredith@rosalindfranklin.edu
authors.forename: Gloria E
authors.initials: GE
authors.lastname: Meredith
authors.forename: Heinz
authors.initials: H
authors.lastname: Steiner
mesh_terms: D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation / Q000187:drug effects*; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000235:genetics / Q000378:metabolism*; D053634:TYK2 Kinase
chemical_list: D000697:Central Nervous System Stimulants; D012333:RNA, Messenger; D000661:Amphetamine; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; D053634:TYK2 Kinase; C499357:Tyk2 protein, rat