title: The value of combining serum alanine aminotransferase levels and body mass index to predict mortality and medical costs: a 10-year follow-up study of National Health Insurance in Shiga, Japan.
abstract: BACKGROUND
  Evidence suggests that the predictive value of serum alanine aminotransferase (ALT) levels for prognosis, measured by indices such as all-cause mortality and medical costs, may be modified by body mass index (BMI). However, the relationship between serum ALT and BMI has not been satisfactorily elucidated.
  
  
  METHODS
  Four thousand, five hundred and twenty-four community dwelling Japanese National Health Insurance beneficiaries, 40-69 years old, were classified into five categories according to their serum ALT levels (IU/L) (ALT<20, 20< or =ALT<30, 30< or =ALT<40, 40< or =ALT<50 and 50< or =ALT) and followed for 10 years. Hazard ratios for all-cause mortality, with reference to the lowest serum ALT category, and medical costs per person were evaluated for each serum ALT category after analyzing interactions between serum ALT levels and BMI for all-cause mortality and for medical costs.
  
  
  RESULTS
  A significant interaction between serum ALT levels and BMI was observed. In participants below the median BMI, positive, graded relationships were identified between serum ALT levels and all-cause mortality as well as between serum ALT levels and personal medical costs. The multivariate-adjusted hazard ratio in the "50< or =ALT" category showed an approximately 8-fold increase. However, in the participants at or above the median BMI, no significant relationships between serum ALT levels and all-cause mortality or personal medical costs were identified.
  
  
  CONCLUSIONS
  In these Japanese participants, the predictive value of serum ALT levels for prognosis was more evident if BMI was taken into account. A combination of high serum ALT levels and below median BMI was associated with excess mortality and medical costs.
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Japan. ksnkmr@belle.shiga-med.ac.jp
authors.forename: Koshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kanda
authors.forename: Takehito
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Akira
authors.initials: A
authors.lastname: Okayama
authors.forename: Hitotsugu
authors.initials: H
authors.lastname: Ueshima
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D015992:Body Mass Index; D005260:Female; D005102:Health Expenditures / Q000706:statistics & numerical data; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D000410:Alanine Transaminase