title: Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1.
abstract: The 3435C-->T polymorphism at the multidrug resistance gene 1 (MDR1) was examined in 74 patients with human immunodeficiency virus who initiated atazanavir therapy. The MDR1 genotype distribution at position 3435 was 28% CC, 45% CT, and 27% TT. Plasma levels of atazanavir were significantly higher in patients with genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations.
authors.affiliation: Clinical Pharmacokinetic Unit, Hospital Carlos III, Madrid, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodríguez Nóvoa
authors.forename: Pablo
authors.initials: P
authors.lastname: Barreiro
authors.forename: Ana
authors.initials: A
authors.lastname: Rendón
authors.forename: Ana
authors.initials: A
authors.lastname: Barrios
authors.forename: Angélica
authors.initials: A
authors.lastname: Corral
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Jiménez-Nacher
authors.forename: Juan
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use; D000069446:Atazanavir Sulfate; D018791:CD4 Lymphocyte Count; D005260:Female; D019450:Genes, MDR / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009842:Oligopeptides / Q000009:adverse effects* / Q000097:blood* / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D011725:Pyridines / Q000009:adverse effects* / Q000097:blood* / Q000627:therapeutic use; D012367:RNA, Viral / Q000097:blood; D012307:Risk Factors; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D009842:Oligopeptides; D011725:Pyridines; D012367:RNA, Viral; D000069446:Atazanavir Sulfate