Advances in glycoprotein synthesis.
The development of chemical and enzymatic methods for the synthesis of homogeneous glycoproteins is a fascinating challenge at the interface between chemistry and biology. Discussed here are the currently available methods for preparation of homogeneous glycoproteins. These methods include (1) glycopeptide ligation; (2) glycoprotein remodeling; and (3) in vivo suppressor tRNA technology.
Liu
Lei
L
Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Bennett
Clay S
CS
Wong
Chi-Huey
CH
D002236:Carbohydrate Conformation; D006023:Glycoproteins / Q000138:chemical synthesis*; D008958:Models, Molecular; D010447:Peptide Hydrolases; D011487:Protein Conformation
D006023:Glycoproteins; D010447:Peptide Hydrolases