Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis.
Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. However, the serum concentration of Klebs von den Lungen (KL)-6 remained high. Although the mechanisms of lung injury by MTX have not been well defined, serial measurements of serum SPD might be useful for the clinical evaluation of drug-induced acute lung injury.
Taniguchi
K
K
Division of Rheumatic Diseases, Tokyo Metropolitan Bokutoh Hospital, Koutohbashi, Sumida-ku, Tokyo, Japan. kevmed1@excite.co.jp
Usui
Y
Y
Matsuda
T
T
Suzuki
S
S
Fujiki
K
K
Yakusiji
F
F
Tomiyama
J
J
Kinoshita
K
K
Ilzuka
H
H
Kuga
Y
Y
D000208:Acute Disease; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D005938:Glucocorticoids; D008727:Methotrexate