The role of transporters in drug interactions.
Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions can occur in the clinic. These interactions can lead to changes in toxicity and/or efficacy of the affected drug. Here, we review such interactions and ask if these interactions could have been predicted from in vitro data. Conducting such in vitro-in vivo correlation is important for predicting future transporter-based drug interactions.
Endres
Christopher J
CJ
Department of Pharmaceutics, Box 357610, University of Washington, Seattle, WA 98195, USA.
Hsiao
Peng
P
Chung
Francisco S
FS
Unadkat
Jashvant D
JD
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D004077:Digoxin / Q000493:pharmacokinetics; D004347:Drug Interactions; D015248:Gemfibrozil / Q000494:pharmacology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000493:pharmacokinetics; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D008954:Models, Biological; D027361:Organic Anion Transporters / Q000037:antagonists & inhibitors / Q000378:metabolism; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D011802:Quinidine / Q000494:pharmacology
D018528:ATP-Binding Cassette Transporters; D000889:Anti-Arrhythmia Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D026901:Membrane Transport Proteins; D027361:Organic Anion Transporters; D027701:Organic Cation Transport Proteins; D004077:Digoxin; D011802:Quinidine; D015248:Gemfibrozil