Heart surgery in infants with hemophilia.
We describe 2 infants with hemophilia A who had heart surgery under cardiopulmonary bypass with factor VIII replacement therapy, and we recommend a guideline for factor VIII support for cardiac surgery. One child had repair of total anomalous pulmonary venous connection. The second had cardiac catheterization followed by repair of ventricular septal defect and total anomalous pulmonary venous connection. Close collaboration between hematologist, laboratory, cardiologist, and cardiac surgeon is crucial in successful management of coagulation abnormalities during and after surgery.
Murugan
Subramanian Jothi
SJ
Department of Pediatric Cardiology, Leeds General Infirmary, Leeds, United Kingdom. jothidevi1@hotmail.com
Viswanathan
Sangeetha
S
Thomson
John
J
Parsons
Jonathan M
JM
Richards
Mike
M
D016063:Blood Loss, Surgical / Q000517:prevention & control*; D006328:Cardiac Catheterization; D002315:Cardiopulmonary Bypass; D019090:Case Management / Q000592:standards; D000013:Congenital Abnormalities / Q000601:surgery; D005169:Factor VIII / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery*; D006467:Hemophilia A / Q000150:complications*; D006474:Hemorrhagic Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D016343:Monitoring, Intraoperative; D010348:Patient Care Team; D011182:Postoperative Care; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D011300:Preoperative Care; D011667:Pulmonary Veins / Q000002:abnormalities* / Q000601:surgery
C427184:recombinant factor VIII SQ; C078147:F8 protein, human; D005169:Factor VIII