[Antidepressants and cytokines--clinical and experimental studies].
Clinical and experimental studies indicate that stress and depression are associated with the up-regulation of the immune system, including increased production of pro-inflammatory cytokines. When administered to patients or laboratory animals, some of these cytokines induce typical symptoms of depression. It is known that cytokines modulate brain neurotransmission and the activity of the hypothalamic-pituitary-adrenal axis, both of which are disturbed in depression. This review summarizes in vivo, ex vivo and in vitro clinical and experimental studies of the effect of antidepressants on cytokine production. In vitro culture and animal studies in particular suggest that antidepressants of several classes decrease the production of pro-inflammatory cytokines and shift the pro/anti-inflammatory cytokine balance towards the latter. Some studies suggest that immunological disturbances, including changes in cytokine levels, are not shared by all depressive patients, which means that only in certain groups of patients may the immunomodulatory action of antidepressants play a significant role in producing the therapeutic effect.
Obuchowicz
Ewa
E
Zakład Farmakologii Klinicznej Katedry Farmakologii, Slaskiej AM w Katowicach.
Marcinowska
Agnieszka
A
Herman
Zbigniew S
ZS
D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects* / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System / Q000378:metabolism; D066298:In Vitro Techniques; D009490:Neurosecretory Systems / Q000378:metabolism
D000928:Antidepressive Agents; D016207:Cytokines