Durhamycin, a Pentaene Antifungal Antibiotic from Streptomyces durhamensis sp. n.
Durhamycin, derived from a previously undescribed soil isolate, is an apparently new antibiotic active against many of the fungi pathogenic for man and animals. Cultural and morphological characteristics and biochemical reactions of Streptomyces durhamensis are detailed. Methods of extraction of the antibiotic, physicochemical properties, antimicrobial spectrum, and results of mouse toxicity and protection tests are given.
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Division of Laboratories and Research, New York State Department of Health, and Institute of Preventive Medicine, Albany Medical College, Albany, New York.
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