title: Serum gamma-glutamyl transpeptidase levels and hypertension in non-drinkers: a possible role of fatty liver in the pathogenesis of obesity related hypertension.
abstract: The relationships between increases in body mass index (BMI) and increases in hypertension were compared between non-drinkers with elevated serum gamma-glutamyl transpeptidase (gamma-GTP) levels (> or = 50 U/l) and those with normal levels, who comprised 10,952 men and 22,107 women aged 40-59 years recruited from an occupational health clinic. Hypertension was found in 16.1% and 13.5% of the men and women, and elevated serum g-GTP was found in 10.8% and 2.8% of the men and women, respectively. The prevalences of hypertension and elevated serum gamma-GTP levels were both increased with increased BMI. Hypertension was, however, shown to be 1.5 times more prevalent in the persons with elevated serum gamma-GTP levels than in those with normal levels in both sexes, even after adjusting for BMI by a multiple logistic analysis. It can be concluded that elevations of serum gamma-GTP, which are probably a reflection of fatty liver in the non-drinkers, are closely related to the development of hypertension associated with increased obesity.
authors.affiliation: Department of Hygiene, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-02 Japan.
authors.forename: E
authors.initials: E
authors.lastname: Ikai
authors.forename: Y
authors.initials: Y
authors.lastname: Noborizaka
authors.forename: I
authors.initials: I
authors.lastname: Tsuritani
authors.forename: R
authors.initials: R
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D005234:Fatty Liver / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications* / Q000209:etiology; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000209:etiology; D012044:Regression Analysis; D012737:Sex Factors; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase