title: Fifty-three years since Hershey and Chase; much ado about pressure but which pressure is it?
abstract: The events that occur at the initiation of phage infection are discussed, from adsorption through DNA ejection from the virion into the cell. A new model for DNA translocation is described that not only overcomes difficulties associated with previous models of DNA ejection but also provides a mechanism by which both single-stranded genomes and internal phage proteins can be transported from the virion into the cell cytoplasm.
authors.affiliation: Molecular Genetics and Microbiology, Institute for Cell and Molecular Biology, The University of Texas, Austin, TX 78712, USA. Molineux@mail.utexas.edu
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Molineux
mesh_terms: D001435:Bacteriophages / Q000502:physiology* / Q000648:ultrastructure; D001692:Biological Transport; D004279:DNA, Viral / Q000378:metabolism; D016679:Genome, Viral / Q000502:physiology*; D006094:Gram-Positive Bacteria / Q000821:virology; D049673:History, 20th Century; D009997:Osmotic Pressure; D014764:Viral Proteins / Q000502:physiology; D014773:Virology / Q000266:history; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins