Seronegative Sjögren syndrome with asymptomatic autoimmune sclerosing pancreatitis.
We report two elderly patients with seronegative Sjögren syndrome who showed benign swelling of the pancreas on computed tomography. Immunostaining of the biopsied lip tissue or serum examination confirmed an increase in production of IgG4, leading to a diagnosis of autoimmune sclerosing pancreatitis (ASP) as a cause of the asymptomatic swelling of the pancreas. Sicca symptoms and ASP spontaneously improved in one patient, and the other responded well to oral prednisolone. Seronegative Sjögren syndrome and ASP can concurrently occur as a clinical manifestation of the IgG4-related systemic disorder, particularly in elderly subjects, and, in such a case, corticosteroid may be a potent therapeutic option.
Matsuda
Masayuki
M
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi, Matsumoto, Japan. matsuda@hsp.md.shinshu-u.ac.jp
Hamano
Hideaki
H
Yoshida
Takuhiro
T
Gono
Takahisa
T
Uehara
Takeshi
T
Kawa
Shigeyuki
S
Ikeda
Shu-ichi
S
D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012598:Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology
D007074:Immunoglobulin G