Parameterization of sex-limited autosomal linkage analysis for Mx.
Incorporation of sex-limitation (genotype-sex interaction) effects into a model of quantitative trait loci ( QTL) analysis has been shown to increase the power to detect linkage when analyzing traits in which sex limitation is present (Towne et al., 1997). The present note provides a parameterization of the nonscalar sex-limitation ACE model incorporating autosomal sex-limited QTL effects for use with the Mx matrix algebra program (Neale et al., 2002). An example script designed for use with extended sibships that takes advantage of the versatile treatment of covariates within Mx is included.
Medland
Sarah E
SE
Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia. Sarah.Medland@qimr.edu.au
D006801:Humans; D008957:Models, Genetic; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012737:Sex Factors