title: Xanthogranuloma of the sellar region.
abstract: The incidence of diagnosed xanthogranuloma of the sellar region is very low [1, 2, 5, 6]. We report about two cases 1) in a 57-year-old female and 2) in a 5-year-old boy. In both cases radiographic findings revealed an inhomogeneous, contrast enhancing sellar lesion. Histopathology showed the typical features of a xanthogranuloma of the sellar region with cholesterol clefts, lympho-plasmacellular infiltrates, marked hemosiderin deposits, multinucleated foreign body giant cells around cholesterol clefts, accumulation of macrophages and only small epithelial cell clusters [6]. As xanthogranuloma of the sellar region are rarely diagnosed we want to draw attention to this rather unusual diagnosis.
authors.affiliation: Department of Neurosurgery, Johann-Wolfgang Goethe University Frankfurt, Frankfurt, Germany. c.s.jung@em.uni-frankfurt.de
authors.forename: C S
authors.initials: CS
authors.lastname: Jung
authors.forename: A
authors.initials: A
authors.lastname: Schänzer
authors.forename: E
authors.initials: E
authors.lastname: Hattingen
authors.forename: K H
authors.initials: KH
authors.lastname: Plate
authors.forename: V
authors.initials: V
authors.lastname: Seifert
mesh_terms: D002675:Child, Preschool; D002784:Cholesterol / Q000378:metabolism; D003397:Craniopharyngioma / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D006485:Hemosiderin / Q000378:metabolism; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010902:Pituitary Gland / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012658:Sella Turcica / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D016896:Treatment Outcome; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery
chemical_list: D006485:Hemosiderin; D002784:Cholesterol