Intraoperative sentinel lymph node mapping using a new sterilizable magnetometer in patients with nonsmall cell lung cancer.
OBJECTIVE
We recently developed a novel method for sentinel lymph node mapping using magnetic force. However, problems with the sterility and sensitivity of the magnetometer made intraoperative sentinel lymph node mapping impossible. The purpose of this study was to test the utility of a new, more sensitive, sterilizable magnetometer developed in our institute for in vivo sentinel lymph node mapping in patients with nonsmall cell lung cancer.


METHODS
Ferumoxides (magnetite) served as the tracer. Twenty patients with nonsmall cell lung cancer participated in the study. Each received 5 mL of ferumoxides, which were injected around their tumor. Magnetic force was then measured intraoperatively using the new sterilizable magnetometer.


RESULTS
The in vivo sentinel lymph node detection rate was 80.0% (16 of 20). The accuracy, sensitivity, and false-negative rates were 100% (16 of 16), 100% (4 of 4) and 0% (0 of 12), respectively. Our preliminary study indicates that our new magnetometer enables in vivo sentinel lymph node mapping in patients with nonsmall cell lung cancer.


CONCLUSIONS
This device safely and accurately detected sentinel lymph nodes in nonsmall cell lung cancer patients.
Minamiya
Yoshihiro
Y
Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan. minamiya@med.akita-u.ac.jp
Ito
Manabu
M
Katayose
Yoshihisa
Y
Saito
Hajime
H
Imai
Kazuhiro
K
Sato
Yusuke
Y
Ogawa
Jun-ichi
J
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D003102:Colloids; D003911:Dextrans; D005188:False Negative Reactions; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D015552:Injections, Intralesional; D007501:Iron / Q000032:analysis; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008280:Magnetics / Q000295:instrumentation*; D058185:Magnetite Nanoparticles; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D010087:Oxides / Q000032:analysis; D010316:Particle Size; D011013:Pneumonectomy; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000295:instrumentation*; D013242:Sterilization; D013535:Suspensions
D003102:Colloids; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D013535:Suspensions; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide