Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.
CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.
Polley
Rosalind
R
Immunology and Infection Unit, Dept. of Biology, University of York, P.O. Box 373, York YO10 5YW, United Kingdom.
Stager
Simona
S
Prickett
Sara
S
Maroof
Asher
A
Zubairi
Soombul
S
Smith
Deborah F
DF
Kaye
Paul M
PM
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016219:Immunotherapy, Adoptive; D007893:Leishmania donovani / Q000235:genetics / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000628:therapy*; D051379:Mice; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000096:biosynthesis / Q000235:genetics
D000953:Antigens, Protozoan; D010047:Ovalbumin