Frequency of chromosomal aneuploidies and deletions of the RB and TP53 genes in MALT lymphomas harboring the t(14;18)(q32;q21).
The t(14;18)(q32;q21) involving the MALT1/MLT and IGH genes has been identified recently as a recurrent abnormality in mucosa-associated lymphoid tissue (MALT) lymphomas. The frequency of secondary chromosomal aberrations in MALT lymphomas harboring the t(14;18) is largely unknown. We therefore analyzed six t(14;18)-positive MALT lymphomas (five parotid, one conjunctiva) by interphase fluorescence in situ hybridization for aneuploidies of chromosomes 3, 7, 12, 18, and X, gains or disruption of the CMYC/8q24 and BCL6/3q27 genes, as well as deletions of the retinoblastoma and TP53 tumor suppressor genes. Except for one MALT lymphoma of the parotid with trisomy 3, neither aneuploidies nor deletions were detected in any of our cases.
Murga Penas
Eva Maria
EM
Department of Oncology and Hematology, University Hospital Hamburg-Eppendorf, Germany.
Hinz
Kristina
K
Biller
Laura
L
Zivkovic
Tijana
T
Röser
Kerstin
K
Löning
Thomas
T
Parwaresch
Reza
R
Bokemeyer
Carsten
C
Dierlamm
Judith
J
D000782:Aneuploidy; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D017353:Gene Deletion; D016161:Genes, Retinoblastoma; D016158:Genes, p53; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy