title: The effects of local platelet rich plasma delivery on diabetic fracture healing.
abstract: Several studies have documented that diabetes impairs bone healing clinically and experimentally. The percutaneous delivery of platelet rich plasma (PRP) was used in the diabetic BB Wistar femur fracture model to investigate the use of PRP as a concentrated source of critical early growth factors on bone healing. PRP delivery at the fracture site normalized the early (cellular proliferation and chondrogenesis) parameters while improving the late (mechanical strength) parameters of diabetic fracture healing. These results suggest a role for PRP in mediating diabetic fracture healing and potentially other high risk fractures.
authors.affiliation: New Jersey Institute of Technology, Department of Biomedical Engineering, 323 Martin Luther King Jr. Boulevard, Newark, New Jersey 07102, USA.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gandhi
authors.forename: Christopher
authors.initials: C
authors.lastname: Doumas
authors.forename: Christopher
authors.initials: C
authors.lastname: Dumas
authors.forename: J Patrick
authors.initials: JP
authors.lastname: O'Connor
authors.forename: J Russell
authors.initials: JR
authors.lastname: Parsons
authors.forename: Sheldon S
authors.initials: SS
authors.lastname: Lin
mesh_terms: D000818:Animals; D001792:Blood Platelets; D001803:Blood Transfusion; D002455:Cell Division; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D017102:Fracture Healing; D008297:Male; D051381:Rats; D017208:Rats, Wistar