title: The MicroRNA pathway plays a regulatory role in stem cell division.
abstract: One of the key characteristics of stem cells is their capacity for self-renewal for long periods of time. In this respect, stem cells are similar to cancer cells, which also have the ability to escape cell cycle stop signals. Therefore, a critical question in stem cell and cancer biology is how cell division is regulated in these cell types. In this review, we summarize recent progress and describe future challenges to understanding the role the microRNA pathway plays in regulating mechanisms controlling stem cell division.
authors.affiliation: Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Shcherbata
authors.forename: S
authors.initials: S
authors.lastname: Hatfield
authors.forename: E J
authors.initials: EJ
authors.lastname: Ward
authors.forename: S
authors.initials: S
authors.lastname: Reynolds
authors.forename: K A
authors.initials: KA
authors.lastname: Fischer
authors.forename: H
authors.initials: H
authors.lastname: Ruohola-Baker
mesh_terms: D000818:Animals; D002455:Cell Division; D016193:G1 Phase / Q000502:physiology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D016196:S Phase / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
chemical_list: D035683:MicroRNAs