Longitudinal analysis of Severe Acute Respiratory Syndrome (SARS) coronavirus-specific antibody in SARS patients.
The serum antibodies to severe acute respiratory syndrome (SARS) coronavirus of 18 SARS patients were checked at 1 month and every 3 months after disease onset. All of them except one, who missed blood sampling at 1 month, tested positive for the immunoglobulin G (IgG) antibody at 1 month. Fifteen out of 17 tested positive for the IgM antibody at 1 month. The serum IgM antibody of most patients became undetectable within 6 months after the onset of SARS. The IgG antibody of all 17 patients, whose serum was checked 1 year after disease onset, remained positive.
Chang
Shan-Chwen
SC
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. sc4030@ha.mc.ntu.edu.tw
Wang
Jann-Tay
JT
Huang
Li-Min
LM
Chen
Yee-Chun
YC
Fang
Chi-Tai
CT
Sheng
Wang-Huei
WH
Wang
Jiun-Ling
JL
Yu
Chong-Jen
CJ
Yang
Pan-Chyr
PC
D000914:Antibodies, Viral / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D008137:Longitudinal Studies; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D045169:Severe Acute Respiratory Syndrome / Q000821:virology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M