Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.
By comparing mammalian genomes, we and others have identified actively transcribed Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences and insertion sites. To elucidate the functions of evolutionarily conserved retrotransposon-derived genes in mammalian development, we produced mice that lack one of these genes, Peg10 (paternally expressed 10), which is a paternally expressed imprinted gene on mouse proximal chromosome 6. The Peg10 knockout mice showed early embryonic lethality owing to defects in the placenta. This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development.
Ono
Ryuichi
R
Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Nakamura
Kenji
K
Inoue
Kimiko
K
Naruse
Mie
M
Usami
Takako
T
Wakisaka-Saito
Noriko
N
Hino
Toshiaki
T
Suzuki-Migishima
Rika
R
Ogonuki
Narumi
N
Miki
Hiromi
H
Kohda
Takashi
T
Ogura
Atsuo
A
Yokoyama
Minesuke
M
Kaneko-Ishino
Tomoko
T
Ishino
Fumitoshi
F
D000818:Animals; D051017:Apoptosis Regulatory Proteins; D019175:DNA Methylation; D004268:DNA-Binding Proteins; D020964:Embryo Loss / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D051379:Mice; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D010312:Parthenogenesis / Q000235:genetics; D010920:Placenta / Q000473:pathology* / Q000502:physiology; D011247:Pregnancy; D016601:RNA-Binding Proteins; D018626:Retroelements; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C110780:Peg10 protein, mouse; D016601:RNA-Binding Proteins; D018626:Retroelements; D014157:Transcription Factors