The effects of local platelet rich plasma delivery on diabetic fracture healing.
Several studies have documented that diabetes impairs bone healing clinically and experimentally. The percutaneous delivery of platelet rich plasma (PRP) was used in the diabetic BB Wistar femur fracture model to investigate the use of PRP as a concentrated source of critical early growth factors on bone healing. PRP delivery at the fracture site normalized the early (cellular proliferation and chondrogenesis) parameters while improving the late (mechanical strength) parameters of diabetic fracture healing. These results suggest a role for PRP in mediating diabetic fracture healing and potentially other high risk fractures.
Gandhi
Ankur
A
New Jersey Institute of Technology, Department of Biomedical Engineering, 323 Martin Luther King Jr. Boulevard, Newark, New Jersey 07102, USA.
Doumas
Christopher
C
Dumas
Christopher
C
O'Connor
J Patrick
JP
Parsons
J Russell
JR
Lin
Sheldon S
SS
D000818:Animals; D001792:Blood Platelets; D001803:Blood Transfusion; D002455:Cell Division; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D017102:Fracture Healing; D008297:Male; D051381:Rats; D017208:Rats, Wistar