title: Oligofructose promotes satiety in healthy human: a pilot study.
abstract: OBJECTIVE
  The administration of a fermentable dietary fibre (oligofructose) in rats increases satietogenic gut peptides and lowered spontaneous energy intake. The aim of the study was to assess the relevance of those effects of oligofructose on satiety and energy intake in humans.
  
  
  METHODS
  Single-blinded, crossover, placebo-controlled design, pilot study.
  
  
  METHODS
  Volunteers included five men and five women aged 21-39 years, BMI ranging from 18.5 to 27.4 kg/m(2), were randomly assigned as described below.
  
  
  METHODS
  Subjects were included in two 2-week experimental phases during which they received either fibre (oligofructose (OFS)) or placebo (dextrine maltose (DM)); a 2-week washout period was included between crossover phases. In total, 8 g OFS or 8 g DM were ingested twice daily (16 g/day in total). Energy intake, hunger, satiety, fullness and prospective food consumption were assessed with analogue scales at the end of each experimental phase.
  
  
  RESULTS
  During breakfast, OFS significantly increases the satiety (P=0.04) without any difference on other sensations as compared to DM treatment periods. After lunch, no significant differences are observed between treatment period. At dinner, OFS significantly increases satiety (P=0.04), reduces hunger (P=0.04) and prospective food consumption (P=0.05). The energy intake at breakfast and lunch are significantly lower (P=0.01, 0.03, respectively) after OFS treatment than after DM treatment. Total energy intake per day is 5% lower during OFS than in DM period.
  
  
  CONCLUSIONS
  Oligofructose treatment increases satiety following breakfast and dinner, reduces hunger and prospective food consumption following dinner. This pilot study presents a rationale to propose oligofructose supplements in the management of food intake in overweight and obese patients.
authors.affiliation: Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Université catholique de Louvain, Brussels, Belgium.
authors.forename: P D
authors.initials: PD
authors.lastname: Cani
authors.forename: E
authors.initials: E
authors.lastname: Joly
authors.forename: Y
authors.initials: Y
authors.lastname: Horsmans
authors.forename: N M
authors.initials: NM
authors.lastname: Delzenne
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D002149:Energy Intake / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005285:Fermentation; D006801:Humans; D008297:Male; D009765:Obesity / Q000517:prevention & control*; D009844:Oligosaccharides / Q000008:administration & dosage*; D010865:Pilot Projects; D012527:Satiation / Q000187:drug effects* / Q000502:physiology; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D009844:Oligosaccharides; C120489:oligofructose