title: [Aortic valve replacement for the patient with Osler-Rendu-Weber disease].
abstract: Osler Rendu-Weber (O-R W) disease (hereditary haemorrhagic telangiectasia) is characterized by an anormality of the peripheral blood vessels which often causes recurrent epistaxis. We presented a case of aortic valve replacement for the patient with O-R-W disease. A 75-year-old woman diagnosed as O-R-W disease with chest pain and dyspnea was admitted. Preoperative transthoratic echocardiography showed severe aortic valve stenosis (AS) with a pressure gradient (from left ventricle to ascending aorta) of 72.5 mmHg. Urgent aortic valve replacement (AVR) was performed after preoperative hormonal (estrogen-progesterone) therapy, that might be effective for bleeding from vascular ectasia. No hemorrhagic tendency was recognized and the postoperative course was uneventful.
authors.affiliation: Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Seike
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Nagashima
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: H
authors.initials: H
authors.lastname: Ishitoya
authors.forename: N
authors.initials: N
authors.lastname: Hibino
authors.forename: T
authors.initials: T
authors.lastname: Tomino
authors.forename: T
authors.initials: T
authors.lastname: Nakata
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D004844:Epistaxis / Q000209:etiology; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications*