Screening for crystalline salts via mechanochemistry.
Neat grinding and solvent-drop grinding methods are found to be effective screening tools for indicating the potential for crystalline salt formation involving a given acid-base pair, as demonstrated with two model pharmaceuticals.
Trask
Andrew V
AV
Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Haynes
Delia A
DA
Motherwell
W D Samuel
WD
Jones
William
W