title: Association between migraine and HLA-DRB1 gene polymorphisms.
abstract: We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA-DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA-DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.
authors.affiliation: Neurology III-Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126, Turin, Italy. irainero@molinette.piemonte.it
authors.forename: Innocenzo
authors.initials: I
authors.lastname: Rainero
authors.forename: Edvige
authors.initials: E
authors.lastname: Fasano
authors.forename: Elisa
authors.initials: E
authors.lastname: Rubino
authors.forename: Chiara
authors.initials: C
authors.lastname: Rivoiro
authors.forename: Walter
authors.initials: W
authors.lastname: Valfrè
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gallone
authors.forename: Lidia
authors.initials: L
authors.lastname: Savi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gentile
authors.forename: Rossana
authors.initials: R
authors.lastname: Lo Giudice
authors.forename: Paola
authors.initials: P
authors.lastname: De Martino
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Dall'Omo
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pinessi
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000235:genetics*; D020326:Migraine without Aura / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains