Inflammation and stroke: therapeutic effects of adenoviral expression of secretory Leukocyte Protease Inhibitor.
Inflammation is a fundamental reaction of the organism aimed to protect, defend and amend diverse forms of injuries. Stroke, an ischemic condition of the brain, provokes acute and chronic inflammatory reactions composed of brain cells as well as circulating immune inflammatory cells. In response to ischemia, brain cells transcribe and express inflammatory proteins that orchestrate numerous biochemical pathways, some of which of potential detrimental effects. This review paper is aimed to delineate strategies that may enable the discovery of novel therapeutic targets for the discovery of drugs for stroke. Soluble Leukocyte Protease Inhibitor (SLPI) serves as a prime example for this strategy.
Feuerstein
Giora
G
Translational Medicine, A3153, Wyeth Research, Collegeville, Pennsylvania 19426, USA. feuersg@wyeth.com
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology*; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D006801:Humans; D007249:Inflammation; D007511:Ischemia / Q000473:pathology; D008954:Models, Biological; D009000:Monocytes / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D053481:Secretory Leukocyte Peptidase Inhibitor; D020521:Stroke / Q000378:metabolism / Q000473:pathology*
D018925:Chemokines; D016207:Cytokines; D011480:Protease Inhibitors; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D012333:RNA, Messenger; C506814:SLPI protein, human; D053481:Secretory Leukocyte Peptidase Inhibitor; C506816:Slpi protein, rat