Phytochemistry and antimycobacterial activity of Chlorophytum inornatum.
In a project to investigate plant derived natural products from the Liliaceae with activity against fast-growing strains of mycobacteria, we have identified two new metabolites from Chlorophytum inornatum. The active principle, a new homoisoflavanone (1) was identified as 3-(4'-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one. The metabolite assigned as 7-(1'-hydroxyethyl)-2-(2''-hydroxyethyl)-3,4-dihydrobenzopyran (2) was characterised by extensive 1- and 2D NMR spectroscopy. The antimycobacterial activity of this plant was mainly due to the homoisoflavonoid which exhibited minimum inhibitory values ranging from 16-256 microg/ml against four strains of fast-growing mycobacteria.
O'Donnell
Gemma
G
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Bucar
Franz
F
Gibbons
Simon
S
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000070357:Asparagaceae / Q000737:chemistry* / Q000378:metabolism; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009161:Mycobacterium / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D012015:Reference Standards
C509450:3-(4'-methoxybenzyl)-7,8-methylenedioxychroman-4-one; C509451:7-(1'-hydroxyethyl)-2-(2''-hydroxyethyl)-3,4-dihydrobenzopyran; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D007529:Isoflavones