title: Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy.
abstract: Renal osteodystrophy (ROD) is one of the most common complications affecting patients with chronic renal failure both before and after the initiation of maintenance dialysis, but macrognathia secondary to ROD is rare. Usually, enlarged jaws due to ROD do not return to their normal contours after the treatment of hyperparathyroidism. To the authors' knowledge, this article describes the second case of macrognathia secondary to dialysis-related ROD treated successfully by parathyroidectomy. Immunohistochemical study of the maxilla confirmed that parathyroidectomy could stop maladaptive parathyroid hormone stimulation, which leads not only to the formation of osteoblastic progenitors that become fibroblast-like cells but also to osteoclast formation.
authors.affiliation: Department of Oral Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki-shi, Okayama 701-0192, Japan. denthata@med.kawasaki-m.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Hata
authors.forename: I
authors.initials: I
authors.lastname: Irei
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Nagatsuka
authors.forename: M
authors.initials: M
authors.lastname: Hosoda
mesh_terms: D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008439:Maxillary Diseases / Q000000981:diagnostic imaging / Q000601:surgery; D008875:Middle Aged; D016105:Parathyroidectomy; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects