New synthetic thiocolchicine derivatives as lowtoxic anticancer agents.
New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.
Lee
Sun-Hee
SH
Department of Chemistry, Seoul Women's University, Seoul, Korea.
Park
Sun-Kyoung
SK
Kim
Jeong-Mi
JM
Kim
Myung-Hwa
MH
Kim
Kwang-Hee
KH
Chun
Kwang-Woo
KW
Cho
Kyung-Hea
KH
Youn
Ji-Youn
JY
Namgoong
Sung Keon
SK
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D016466:CHO Cells; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003078:Colchicine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50
D000970:Antineoplastic Agents; C014856:thiocholchicine; D003078:Colchicine