Unraveling the mystery of gammadelta T cell recognizing lipid A.
Traditionally, the materials which are regarded as antigens recognized by gammadelta T lymphocytes are protein and carbohydrate, not nucleic acid or lipid. Recently, it has been demonstrated that gammadelta T cells can recognize lipid A and directly induce immune responses that involve CD1 (cluster of differentiation type 1) family and Toll like receptors (TLRs). This is a review about the interacting-mechanism, immunological effect and clinical application of them.
Cui
Yongchun
Y
Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Cui
Lianxian
L
He
Wei
W
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology*; D006801:Humans; D008050:Lipid A / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
D018949:Antigens, CD1; D008050:Lipid A; D016692:Receptors, Antigen, T-Cell, gamma-delta; D051193:Toll-Like Receptors