BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study.
Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
Karamohamed
S
S
Department of Neurology, Boston University School of Medicine, MA, USA.
Latourelle
J C
JC
Racette
B A
BA
Perlmutter
J S
JS
Wooten
G F
GF
Lew
M
M
Klein
C
C
Shill
H
H
Golbe
L I
LI
Mark
M H
MH
Guttman
M
M
Nicholson
G
G
Wilk
J B
JB
Saint-Hilaire
M
M
DeStefano
A L
AL
Prakash
R
R
Tobin
S
S
Williamson
J
J
Suchowersky
O
O
Labell
N
N
Growdon
B N J
BN
Singer
C
C
Watts
R
R
Goldwurm
S
S
Pezzoli
G
G
Baker
K B
KB
Giroux
M L
ML
Pramstaller
P P
PP
Burn
D J
DJ
Chinnery
P
P
Sherman
S
S
Vieregge
P
P
Litvan
I
I
Gusella
J F
JF
Myers
R H
RH
Parsian
A
A
D017668:Age of Onset; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004252:DNA Mutational Analysis; D005192:Family Health; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006720:Homozygote; D015233:Models, Statistical; D020734:Parkinsonian Disorders / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors
D019208:Brain-Derived Neurotrophic Factor