Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds.
Flavonoids are found ubiquitously in higher plants and constitute an important component of the majority of people daily diets. The biological activities of flavonoids cover a very broad spectrum, from anticancer and antibacterial activities through to inhibition of bone resorption. In the present paper, the interactions between flavonoids and lipid bilayers as well as biological membranes and their components are reviewed, with special emphasis on the structure-activity relationships and mechanisms underlying the biological activity of flavonoids.
Hendrich
Andrzej B
AB
Department of Biophysics, Wroclaw Medical University, Poland. hendrich@biofiz.am.wroc.pl
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D018432:Drug Resistance, Multiple; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D008051:Lipid Bilayers / Q000378:metabolism*; D010945:Plants, Edible / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005419:Flavonoids; D007473:Ion Channels; D008051:Lipid Bilayers