title: A simple model to assess and improve adherence to iron chelation therapy with deferoxamine in patients with thalassemia.
abstract: Adherence to deferoxamine (DFO) is vital for the long-term survival of patients with thalassemia; however, currently no measure exists to quantify adherence directly. In this study, 90 patients with thalassemia major underwent liver iron concentration (LIC) assessment by SQUID biosusceptometer, were asked to rate their adherence to DFO using a Numerical Likert Scale (NLS), and were educated about complications of iron overload. Of 38% (n = 28) of patients who rated themselves as very compliant, 19 had elevated LIC related to inadequate dosing of DFO and nine reported nonadherence in the past. Adherence improved after counseling and LIC decreased by 25% (7-60%) in eight previously noncompliant patients who returned for subsequent LIC over 15 months. In conclusion, the NLS seems to be a simple but reliable tool to assess patients' adherence to DFO. Education and frequent noninvasive LIC assessments can improve adherence and iron burden. Elevated LIC does not necessarily reflect concurrent noncompliance; however, it can be an indication of nonadherence in the past.
authors.affiliation: Children's Hospital & Research Center at Oakland, 747 52nd St., Oakland, CA 94609, USA. zpakbaz@mail.cho.org
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pakbaz
authors.forename: Roland
authors.initials: R
authors.lastname: Fischer
authors.forename: Marsha
authors.initials: M
authors.lastname: Treadwell
authors.forename: Robert
authors.initials: R
authors.lastname: Yamashita
authors.forename: Ellen B
authors.initials: EB
authors.lastname: Fung
authors.forename: Lisa
authors.initials: L
authors.lastname: Calvelli
authors.forename: Keith
authors.initials: K
authors.lastname: Quirolo
authors.forename: Drucilla
authors.initials: D
authors.lastname: Foote
authors.forename: Paul
authors.initials: P
authors.lastname: Harmatz
authors.forename: Elliott P
authors.initials: EP
authors.lastname: Vichinsky
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D015913:Chelation Therapy; D002648:Child; D002675:Child, Preschool; D003676:Deferoxamine / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007501:Iron / Q000032:analysis; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008099:Liver / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009929:Organ Size; D010349:Patient Compliance; D010353:Patient Education as Topic; D011446:Prospective Studies; D012650:Self Disclosure; D011795:Surveys and Questionnaires; D017086:beta-Thalassemia / Q000097:blood / Q000188:drug therapy*
chemical_list: D015415:Biomarkers; D007502:Iron Chelating Agents; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine