Thioredoxin and its role in premature newborn biology.
Thioredoxin (Trx) is a redox-active protein that has been shown to regulate various cellular processes due to its thiol-disulfide exchange reaction. It has antioxidant properties and also induces the expression of critical antioxidant enzymes such as manganese superoxide dismutase. Trx along with thioredoxin reductase and peroxiredoxins forms a complete system similar to the glutathione system, but with different and divergent functions. This review is a mini-update on key advances in the role of Trx in signal transduction and premature newborn biology. In addition, this mini-update also reviews recently reported prooxidant properties of Trx that relate to anthracycline redox cycling.
Das
Kumuda C
KC
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR7205, USA. kdas@uams.edu
D000818:Animals; D018943:Anthracyclines / Q000737:chemistry / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D010084:Oxidation-Reduction; D015398:Signal Transduction; D013879:Thioredoxins / Q000378:metabolism*
D018943:Anthracyclines; D000975:Antioxidants; D013879:Thioredoxins