Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.
A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.
Vallance
Patrick
P
Department of Medicine, Rayne Building, 5 University Street London, WC1E 6JJ, UK. patrick.vallance@ucl.ac.uk
Bush
Hannah D
HD
Mok
B James
BJ
Hurtado-Guerrero
Ramon
R
Gill
Herpreet
H
Rossiter
Sharon
S
Wilden
Jonathan D
JD
Caddick
Stephen
S
D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002384:Catalysis; D003500:Cyclization; D006867:Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000737:chemistry*
D011480:Protease Inhibitors; D013451:Sulfonic Acids; D006867:Hydrolases; D000581:Amidohydrolases; C059999:dimethylargininase; C019723:arginine deiminase