Axon guidance processes in the retinotectal and vomeronasal projection are controlled by Eph receptor tyrosine kinases and ephrins.
The Eph family of receptor tyrosine kinases and their 'ligands', the ephrins, have been shown to play key roles in a number of different developmental processes such as cell migration, boundary formation, axon guidance, synapse formation and vasculogenesis. Here, we summarize recent findings derived from investigating the role of the EphA family during development of the retinotectal and vomeronasal projection uncovering a role of ephrin-A molecules as axon guidance receptors.
Drescher
U
U
MRC Centre for Developmental Neurobiology, King's College London, UK. uwe.drescher@kcl.ac.uk
Knoell
B
B