On the formula for admixture linkage disequilibrium.
Admixture linkage disequilibrium (ALD), a phenomenon created by gene flow between genetically distinct populations, has for some time been used as a tool in gene mapping. It is therefore important to analyze the pattern of ALD over generations. In this study we explore two models of admixture: the gradual admixture (GA) model, in which admixture occurs at a variable rate in every generation; and the immediate admixture (IA) model, a special case of the GA model, in which admixture occurs in a single generation. In the case of ALD, the well-known formula of linkage disequilibrium (Delta(t)=(1-r)t Delta(0)) is not applicable under these two models. We note the effect of a random mating population (RMP) to the gametic frequencies from the parental population to the offspring population, and provide the correct formula for ALD.
Guo
Wei
W
Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, China. guoweidora@hkusua.hku.hk
Fung
Wing K
WK
Shi
Ningzhong
N
Guo
Jianhua
J
D002874:Chromosome Mapping / Q000379:methods*; D005828:Genetics, Population; D015810:Linkage Disequilibrium; D008957:Models, Genetic