title: MR-guided intervention in women with a family history of breast cancer.
abstract: OBJECTIVE
  A study was undertaken to assess the clinical value of magnetic resonance (MR) imaging-guided interventions in women with a family history, but no personal history of breast cancer.
  
  
  METHODS
  Retrospective review was performed on 63 consecutive women who had a family history, but no personal history of breast cancer. A total of 97 lesions were referred for an MR-guided intervention. Standardized MR examinations (1.0 T, T1-weighted 3D FLASH, 0.15 mmolGd-DTPA/kg body weight, prone position) were performed using a dedicated system which allows vacuum assisted breast biopsy or wire localization.
  
  
  RESULTS
  Histologic findings in 87 procedures revealed 9 (10%) invasive carcinomas, 12 (14%) ductal carcinomas in situ, 2 atypical ductal hyperplasias (2.5%) and 2 atypical lobular hyperplasias (2.5%). Sixty-two (71%) benign histologic results are verified by an MR-guided intervention, retrospective correlation of imaging and histology and by subsequent follow-up. In ten lesions the indication dropped since the enhancing lesion was no longer visible. Absent enhancement was confirmed by short-term re-imaging of the noncompressed breast and by follow-up.
  
  
  CONCLUSIONS
  Malignancy was found in 24%, high-risk lesions in 5% of successfully performed MR-guided biopsy procedures. A 57% of MR-detected malignancies were ductal carcinoma in situ. In 10% of the lesions the intervention was not performed, since no enhancing lesion could be reproduced at the date of anticipated intervention. Such problems may be avoided if the initial MRI is performed in the appropriate phase of the menstrual cycle and without hormonal replacement therapy.
authors.affiliation: Institute of Diagnostic Radiology, Technical University Dresden, Germany. Petra.Viehweg@uniklinikum-dresden.de
authors.forename: P
authors.initials: P
authors.lastname: Viehweg
authors.forename: T
authors.initials: T
authors.lastname: Bernerth
authors.forename: M
authors.initials: M
authors.lastname: Kiechle
authors.forename: J
authors.initials: J
authors.lastname: Buchmann
authors.forename: A
authors.initials: A
authors.lastname: Heinig
authors.forename: H
authors.initials: H
authors.lastname: Koelbl
authors.forename: M
authors.initials: M
authors.lastname: Laniado
authors.forename: S H
authors.initials: SH
authors.lastname: Heywang-Köbrunner
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA