The genetic basis for bronchopulmonary dysplasia.
While the 'original' bronchopulmonary dysplasia (BPD) was attributed to the iatrogenic effects of oxygen and barotrauma on the preterm lung, analyses of the 'new' BPD suggests that these environmental effects may contribute to arrested pulmonary development, and that there may also be genetic foundations for the susceptibility to BPD. Twinning, family and population studies implicate heritable factors in the evolution of BPD. The candidate genes examined for their potential role in BPD include surfactant apoprotein and inflammatory genes. With the identification and mapping of single nucleotide polymorphisms (SNPs), an explosion of testing for these genetic components that may contribute to a number of complex, multigenic disease conditions-including BPD-have been initiated. Sophisticated multiplex analyses are now available to link candidate SNPs to conditions such as BPD. However, there continues to be wide variation in the expression of BPD throughout neonatal units. Differentiating the effects caused by environmental and environmental-genetic interactions from isolated genetic etiologies is still problematic and will require carefully designed genetic analyses of preterm infant groups and their families.
Parton
Lance A
LA
Division of Neonatology, Department of Pediatrics, New York Medical College, Maria Fareri Children's Hospital, Westchester Medical Center, Valhalla, NY 10595, USA. Lance_Parton@NYMC.edu
Strassberg
Sonya S
SS
Qian
Dajun
D
Galvin-Parton
Patricia A
PA
Cristea
Ioana A
IA
D000483:Alleles; D001059:Apoproteins / Q000378:metabolism; D001997:Bronchopulmonary Dysplasia / Q000235:genetics*; D004200:Diseases in Twins; D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007249:Inflammation; D015810:Linkage Disequilibrium; D008168:Lung / Q000473:pathology; D008954:Models, Biological; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012127:Respiratory Distress Syndrome, Newborn / Q000235:genetics; D012306:Risk; D013501:Surface-Active Agents / Q000737:chemistry
D001059:Apoproteins; D013501:Surface-Active Agents