title: How to make a curved Drosophila bristle using straight actin bundles.
abstract: This, our Inaugural Article as Academy Members, is ironically our swan song from the field of the actin cytoskeleton. By reviewing what we have learned and what we think is going on during development, we hope to lure you, the reader, into applying your skills to the bristle cell. The processes of the assembly and disassembly of actin bundles is laid out in time and space in an organism that lends itself to genetic manipulation. The cell provides every process you could want: filament nucleation, growth of microvilli, joining of microvillar bundles into modules, assembly of modules into bundles, time-dependent use of at least two crossbridging proteins, filament turnover, treadmilling, disassembly, and filament translocation.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Lewis G
authors.initials: LG
authors.lastname: Tilney
authors.forename: David J
authors.initials: DJ
authors.lastname: DeRosier
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry; D000199:Actins / Q000737:chemistry*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000737:chemistry; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D004330:Drosophila; D008840:Microfilament Proteins / Q000737:chemistry; D008856:Microscopy, Fluorescence; D011485:Protein Binding; D012106:Research; D013997:Time Factors
chemical_list: D000199:Actins; D003598:Cytoskeletal Proteins; D008840:Microfilament Proteins