Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution.
Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi-1-positive cells exfoliated after damage, while Musashi-1 expression in neck cells were upregulated, and proliferating cells diminished before reappearing and increasing in number thereafter. We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation.
Nagata
Hiroshi
H
Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. nagtata@sc.itc.keio.ac.jp
Akiba
Yasutada
Y
Suzuki
Hidekazu
H
Okano
Hideyuki
H
Hibi
Toshifumi
T
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000096:biosynthesis; D002454:Cell Differentiation / Q000502:physiology; D004848:Epithelium / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D009417:Nerve Tissue / Q000166:cytology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010295:Parietal Cells, Gastric / Q000166:cytology / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology*; D012097:Repressor Proteins / Q000096:biosynthesis; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; C489686:Hes5 protein, rat; C491296:Msi1 protein, rat