Phosphoinositides in FCgamma receptor signaling.
Fcgamma receptors mediate a variety of immune responses to IgG-containing complexes. Virtually all of these responses appear to be regulated by phosphoinositides, in particular phosphatidylinositol (4,5)P2 and phosphatidylinositol (3,4,5)P3. Possible downstream effectors of phosphoinositides involved in multiple FcgammaR-mediated events are discussed, as are elements of the signaling pathways that may couple Fcgamma receptors to the enzymes of phosphoinositide metabolism.
Booth
James W
JW
Department of Immunology, University of Toronto, Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, M4N 3M5, Canada. James.Booth@sw.ca
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D010587:Phagocytosis; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010716:Phosphatidylinositols / Q000737:chemistry*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D015539:Platelet Activation; D017452:Receptors, IgG / Q000096:biosynthesis / Q000378:metabolism*; D015290:Second Messenger Systems; D015398:Signal Transduction
D016207:Cytokines; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D017452:Receptors, IgG; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases