title: Pseudomyxoma peritonei and the urinary tract: involvement and treatment related complications.
abstract: BACKGROUND
  Pseudomyxoma peritonei (PMP) is a rare clinical syndrome characterized by intraperitoneal accumulation of mucus produced by neoplastic cells of mostly appendiceal origin. The aim of this study was to analyze primary and secondary involvement and treatment-related complications of the urinary tract in PMP.
  
  
  METHODS
  A retrospective study of 92 patients with PMP, treated by cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) at The Netherlands Cancer Institute between 1996 and 2004.
  
  
  RESULTS
  Seven patients presented with involvement of the urinary tract. Major urologic complications occurred in five patients, of which two had secondary involvement of the urinary tract. Major urologic complications consisted predominantly of surgical complications related to the bladder. All patients with secondary involvement and/or urologic complications had undergone previous pelvic surgery.
  
  
  CONCLUSIONS
  The urinary tract is rarely involved in patients with PMP. Secondary involvement is mostly observed and may be a result of seeding of PMP of pelvic origin after prior pelvic surgery. There is a low urologic complication risk of treatment with cytoreduction and HIPEC. The combination of secondary involvement and previous pelvic surgery is an omen of treatment-related urologic complications, necessitating (surgical) re-interventions and further management in close collaboration with urologists.
authors.affiliation: Department of Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: Smeenk
authors.forename: A
authors.initials: A
authors.lastname: Bex
authors.forename: V J
authors.initials: VJ
authors.lastname: Verwaal
authors.forename: S
authors.initials: S
authors.lastname: Horenblas
authors.forename: F A N
authors.initials: FA
authors.lastname: Zoetmulder
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D009366:Neoplasm Seeding; D010388:Pelvis / Q000601:surgery*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D011553:Pseudomyxoma Peritonei / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D001747:Urinary Bladder Fistula / Q000453:epidemiology; D014550:Urinary Incontinence, Stress / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology
chemical_list: D000970:Antineoplastic Agents