Splicing regulators: targets and drugs.
Silencing of splicing regulators by RNA interference, combined with splicing-specific microarrays, has revealed a complex network of distinct alternative splicing events in Drosophila, while a high-throughput screen of more than 6,000 compounds has identified drugs that interfere specifically and directly with one class of splicing regulators in human cells.
Yeo
Gene Wei-Ming
GW
Crick-Jacobs Center for Computational and Theoretical Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. geneyeo@salk.edu
D017398:Alternative Splicing / Q000187:drug effects / Q000235:genetics; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D012326:RNA Splicing / Q000187:drug effects* / Q000235:genetics*