Effects of concentrated ambient particles on heart rate variability in spontaneously hypertensive rats.
In the present study, the cardiovascular toxicity of PM(2.5) was determined in spontaneously hypertensive (SH) rats using the standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences of adjacent normal-to-normal intervals (RMSSD) as outcome measurements. Four SH rats implanted with radiotelemetry transmitters were repeatedly exposed to concentrated PM(2.5) in nose-only exposure chambers. Gravimetric analysis revealed the mean post-concentrating mass concentration of particles during the 5 h of exposure was 202 mug/m(3). Using each animal as its own control and linear mixed-effects model, to adjust for circadian nature and individual differences, we found that SDNN decreased by 15% initially then gradually decreased to 60% of the initial value at the end of exposure. Our results indicate that concentrated PM(2.5) may decrease SDNN on SH rats during PM exposure. The study also showed that SDNN is more sensitive to PM induced effects than RMSSD.
Chang
Chuen-Chau
CC
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University.
Hwang
Jing-Shiang
JS
Chan
Chang-Chuan
CC
Wang
Peng-Yau
PY
Hu
Tsuey-Hwa
TH
Cheng
Tsun-Jen
TJ
D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D006339:Heart Rate / Q000502:physiology*; D019570:Inhalation Exposure; D008297:Male; D010316:Particle Size; D051381:Rats; D011918:Rats, Inbred SHR; D013624:Taiwan
D000393:Air Pollutants