Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters.
We present the three-dimensional structure of the N-terminal FK506-binding protein (FKBP)-like domain of the immunophilin FKBP42 from Arabidopsis thaliana. The data provide the structural background for the explanation of key functional properties reported previously.
Weiergräber
Oliver H
OH
Institut für Biologische Informationsverarbeitung, IBI-2, Biologische Strukturforschung, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany.
Eckhoff
Andreas
A
Granzin
Joachim
J
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D017360:Arabidopsis / Q000737:chemistry* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000737:chemistry* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D022021:Tacrolimus Binding Proteins / Q000737:chemistry* / Q000378:metabolism
D018435:ATP Binding Cassette Transporter, Subfamily B; D029681:Arabidopsis Proteins; C471286:TWD1 protein, Arabidopsis; D022021:Tacrolimus Binding Proteins