title: New synthetic thiocolchicine derivatives as lowtoxic anticancer agents.
abstract: New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.
authors.affiliation: Department of Chemistry, Seoul Women's University, Seoul, Korea.
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Lee
authors.forename: Sun-Kyoung
authors.initials: SK
authors.lastname: Park
authors.forename: Jeong-Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Myung-Hwa
authors.initials: MH
authors.lastname: Kim
authors.forename: Kwang-Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Kwang-Woo
authors.initials: KW
authors.lastname: Chun
authors.forename: Kyung-Hea
authors.initials: KH
authors.lastname: Cho
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Youn
authors.forename: Sung Keon
authors.initials: SK
authors.lastname: Namgoong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D016466:CHO Cells; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003078:Colchicine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: D000970:Antineoplastic Agents; C014856:thiocholchicine; D003078:Colchicine