title: Impaired implicit sequence learning in depression: a probe for frontostriatal dysfunction?
abstract: BACKGROUND
  Implicit learning through motor sequencing tasks is sensitive to basal ganglia dysfunction. Consequently, it is ideally suited for testing elements of the frontostriatal model of major depression and performance can be related to key clinical, neuropsychological, vascular and biochemical data.
  
  
  METHODS
  Twenty-one subjects with moderate to severe unipolar depression and 21 age-, sex- and education-matched controls were recruited. Clinical, vascular and biochemical data were recorded. Subjects were administered a battery of neuropsychological tests that assessed speed of processing, working memory, learning, memory, language, perceptual organization and executive functioning. Additionally, subjects were administered a motor sequencing implicit learning task. Implicit learning is assumed when reaction times improve during the sequenced condition as compared to the pseudo-random baseline condition.
  
  
  RESULTS
  The rate of implicit learning in persons with depression was only half that of control subjects (3.6% v. 7.3%). Lower rates of implicit learning in patients were associated with poorer performance on neuropsychological tests of visuomotor speed and mental flexibility, longer duration of depressive episode and severity of acute stress. In a small number of subjects, poorer performance was also related to past suicide attempt.
  
  
  CONCLUSIONS
  Impaired implicit learning in persons with depression is consistent with frontostriatal dysfunction. Performance is related to some clinical characteristics and to neuropsychological functioning on tests of visuomotor speed and mental flexibility.
authors.affiliation: Brain & Mind Research Institute, University of Sydney, Sydney, Australia. snaismith@med.usyd.edu.au
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Naismith
authors.forename: Ian B
authors.initials: IB
authors.lastname: Hickie
authors.forename: Philip B
authors.initials: PB
authors.lastname: Ward
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Scott
authors.forename: Craig
authors.initials: C
authors.lastname: Little
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D003342:Corpus Striatum / Q000503:physiopathology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D007858:Learning; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology