Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.
Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic changes; however, until now, there has been no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University of Pennsylvania, was held from December 1 to 3, 2004 with the goal of establishing an internationally accepted uniform nomenclature for the pathology of genetically engineered mouse models of pancreatic exocrine neoplasia. The pancreatic pathology in 12 existing mouse models of pancreatic neoplasia was reviewed at this workshop, and a standardized nomenclature with definitions and associated images was developed. It is our intention that this nomenclature will standardize the reporting of genetically engineered mouse models of pancreatic exocrine neoplasia, that it will facilitate comparisons between genetically engineered mouse models and human pancreatic disease, and that it will be broad enough to accommodate newly emerging mouse models of pancreatic neoplasia.
Hruban
Ralph H
RH
Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. rhruban@jhmi.edu
Adsay
N Volkan
NV
Albores-Saavedra
Jorge
J
Anver
Miriam R
MR
Biankin
Andrew V
AV
Boivin
Gregory P
GP
Furth
Emma E
EE
Furukawa
Toru
T
Klein
Alison
A
Klimstra
David S
DS
Kloppel
Gunter
G
Lauwers
Gregory Y
GY
Longnecker
Daniel S
DS
Luttges
Jutta
J
Maitra
Anirban
A
Offerhaus
G Johan A
GJ
Pérez-Gallego
Lucía
L
Redston
Mark
M
Tuveson
David A
DA
D000818:Animals; D004195:Disease Models, Animal; D005818:Genetic Engineering; D006801:Humans; D051379:Mice; D046790:Pancreas, Exocrine / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology*; D009626:Terminology as Topic