Lack of effect of some dopamine and non-dopamine receptor ligands on amphetamine-induced changes in the rat brain neuropeptide Y system.
None of the receptor ligands studied: the dopamine D2 antagonist eticlopride, D2/D3 antagonist haloperidol, alpha1-adrenergic antagonist prazosin, N-methyl-D-aspartate antagonist MK-801, 5-HT2/D2 antagonist mianserin, D2/D3 agonist quinpirole and alpha2-adrenergic agonist clonidine co-administrated with repeated amphetamine (AMPH) injections blocked the AMPH-induced decrease in the striatal and nucleus accumbens neuropeptide Y (NPY) levels. Only the D1/D5 receptor antagonist SCH 23390 insignificantly attenuated this effect what suggests that these dopamine receptor subtypes may partially mediate AMPH effect on NPY. Moreover, the results of multiple administrations of the receptor ligands to control rats indicate that the NPY systems in both structures under study are modulated in the same manner by dopaminergic activity and differentially by adrenergic, N-methyl-D-aspartate and serotonergic activity.
Obuchowicz
Ewa
E
Department of Pharmacology, Silesian University School of Medicine, Medykó 18, PL 40-752 Katowice, Poland. eobuchowicz@slam.katowice.pl
Herman
Zbigniew S
ZS
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects* / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008024:Ligands; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D011224:Prazosin / Q000494:pharmacology; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism; D012457:Salicylamides / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D018691:Excitatory Amino Acid Antagonists; D008024:Ligands; D009478:Neuropeptide Y; D017981:Receptors, Neurotransmitter; D012457:Salicylamides; D019257:Quinpirole; D016291:Dizocilpine Maleate; D000661:Amphetamine; C045989:eticlopride; D003000:Clonidine; D011224:Prazosin