title: [A case of systemic lupus erythematosus associated with hypertrophic cardiomyopathy].
abstract: The patient was a 37-year-old female, who was diagnosed as having systemic lupus erythematosus (SLE) with nephrotic syndrome in 1991. SLE has been well controlled with a combination therapy of prednisolone, cyclophosphamide and mizoribine. She was admitted to our hospital for chest pain on exertion in June 2002. A grade of 2 systolic murmur was heard along left sternal border and edema in the both lower legs was present. Laboratory findings showed proteinuria and anemia. Serological tests did not show decrease in complements and was negative for autoantibodies including anti-ds-DNA antibody. The serum level of brain natriuretic peptide was 651 pg/ml. On chest X-ray films, there were no remarkable findings. An electrocardiogram showed a pattern of left ventricular hypertrophy with inverted T wave. The heart ultrasonic test recognized asymmetric hypertrophy of the septum, being more prominent in the apex, but there was no obstruction of the left ventricular outflow tract. Examination of an endomyocardial biopsy specimen showed disarray and mild hypertrophy of myocardial cells, which were compatible with hypertrophic cardiomyopathy (HCM), but there were no pathological findings specific for SLE. Additional treatment with beta-blocker under a diagnosis of HCM resulted in a favorable response. Although 7 SLE patients with HCM have been reported, endomyocardial biopsy was not performed. There appears to have been a chance association between SLE and HCM, considering the clinical courses in reported cases and the pathological findings in our case.
authors.affiliation: First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kotani
authors.forename: Tohru
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Michiyo
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Suzue
authors.initials: S
authors.lastname: Hirano
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tabushi
authors.forename: Maki
authors.initials: M
authors.lastname: Kagitani
authors.forename: Shigeki
authors.initials: S
authors.lastname: Makino
authors.forename: Fumio
authors.initials: F
authors.lastname: Terasaki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D001706:Biopsy; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D009206:Myocardium / Q000473:pathology
chemical_list: D000319:Adrenergic beta-Antagonists