Walking with myosin V.
The cytoplasm of cells is teaming with vesicles and other cargo that are moving along tracks of microtubules or actin filaments, powered by myosins, kinesins and dyneins. Myosin V has been implicated in several types of intracellular transport. The mechanism by which myosin V moves processively along actin filaments has been the subject of many biophysical and biochemical studies and a consensus is starting to emerge about how this minute molecular motor operates.
Sellers
James R
JR
Laboratory of Molecular Physiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1762, USA. sellersj@nhlbi.nih.gov
Veigel
Claudia
C
D008841:Actin Cytoskeleton / Q000737:chemistry*; D001693:Biological Transport, Active; D008954:Models, Biological; D020409:Molecular Motor Proteins; D009068:Movement; D024701:Myosin Type V / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
D020409:Molecular Motor Proteins; D024701:Myosin Type V