title: Increased cytochrome oxidase activity in adrenal glands of thioacetamide-cirrhotic rats.
abstract: OBJECTIVE
  Cytochrome oxidase activity has been determined in the adrenal glands of thioacetamide (TAA)-cirrhotic rats.
  
  
  METHODS
  Two groups of animals (Control group; n=10 and TAA group; n=11) of three months evolution were used to study the cytochrome oxidase activity in the suprarenal cortex (glomerular, fascicular and reticular layers) and medulla. TAA was administered orally and cytochrome oxidase (COX) activity was assayed by an immunohistochemical technique.
  
  
  RESULTS
  In TAA-cirrhotic rats, COX activity increases in the cortex fascicular layer (221 +/- 1.79 vs 181.9 +/- 2.75; p<0.001) as well as in the medulla (146.6 +/- 1.72 vs 129 +/- 3.09; p<0.001).
  
  
  CONCLUSIONS
  These results make it possible to consider the existence of hypothalamic-pituitary-adrenal-axis and adrenomedullary sympathetic system hyperactivity, both peripheral limbs of the stress system, in this experimental model of cirrhosis.
authors.affiliation: Psychobiology Department, School of Psychology, University of Oviedo, Asturias, Spain.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Méndez-López
authors.forename: Marta
authors.initials: M
authors.lastname: Méndez
authors.forename: Laudino
authors.initials: L
authors.lastname: López
authors.forename: Maria-Angeles
authors.initials: MA
authors.lastname: Aller
authors.forename: Héctor
authors.initials: H
authors.lastname: González-Pardo
authors.forename: María-Paz
authors.initials: MP
authors.lastname: Nava
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez-Patán
authors.forename: Jaime
authors.initials: J
authors.lastname: Arias
authors.forename: Jorge-Luis
authors.initials: JL
authors.lastname: Arias
mesh_terms: D000222:Adaptation, Physiological; D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D003576:Electron Transport Complex IV / Q000096:biosynthesis* / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008102:Liver Circulation / Q000187:drug effects / Q000502:physiology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D017082:Portal Pressure / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide
chemical_list: D013853:Thioacetamide; D003576:Electron Transport Complex IV