title: [Effects of high-energy shock waves on the structure of the immature epiphysis--a histomorphological study].
abstract: OBJECTIVE
  Extracorporeal shock wave treatment of infantile skeleton diseases is theoretical reasonable. The aim of this study was to investigate if extracorporeal shock wave therapy (ESWT) may cause damage to the epiphysis within the energy range of human application doses.
  
  
  METHODS
  18 rabbits were treated with 800 extracorporeal shock waves (Philips lithotripter LDM-E, energy density 0.32 mJ/mm(2)) at the proximal tibia epiphysis. At 72 hours, 14 days and 4 weeks each after shock wave application 6 rabbits were sacrificed.
  
  
  RESULTS
  Histological examination showed no damage to the epiphysis in all treated subjects.
  
  
  CONCLUSIONS
  This experimental study demonstrates that, under the conditions used in human shock wave therapy, no damage to the rabbit epiphysis occurs.
authors.affiliation: Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Universitätsklinikum Essen, Deutschland. kai.nassenstein@uni-essen.de
authors.forename: K
authors.initials: K
authors.lastname: Nassenstein
authors.forename: I
authors.initials: I
authors.lastname: Nassenstein
authors.forename: R
authors.initials: R
authors.lastname: Schleberger
mesh_terms: D000818:Animals; D004838:Epiphyses / Q000293:injuries / Q000473:pathology / Q000528:radiation effects; D008096:Lithotripsy / Q000009:adverse effects; D011817:Rabbits; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013010:Sonication / Q000009:adverse effects*; D013977:Tibia / Q000293:injuries / Q000473:pathology* / Q000528:radiation effects*; D014464:Ultrasonic Therapy / Q000009:adverse effects*