Lunasensor, infradian rhythms, telomeres, and the chronomere program of aging.
According to the redusome hypothesis, the aging of an organism is determined by the shortening of chronomeres (small perichromosomal linear DNA molecules). In this paper, a presumptive role for infradian hormonal rhythms is considered. Endogenous infradian rhythms are supposed to actively interact with those hormonal shifts which are governed by an exogenous infradian gravitational lunar rhythm. As a result of this interaction, the so-called T-rhythm is formed. Peaks of T-rhythms are used as the pacemaker signals to keep the life-long "clockwork" of the brain running. The "ticking" of this clock is realized by the periodically repeated shortening of chronomeres in postmitotic neuroendocrine cells, which occurs just at the maxima of T-rhythms. Shortening of telomeres in mitotic cells in vivo is a witness of the aging of the organism, but not the cause of aging. The primary cause of aging is shortening of chronomeres, the material carriers of a temporal program of development and aging. To recognize exogenous gravitational infradian rhythms, a special physiological system--the "lunasensor" system--evolved. It is assumed that it is a necessity to have a lunasensor as a particular variant of sensors of gravitation.
Olovnikov
Alexey
A
Institute of Biochemical Physics of RAS, Chernyakhovskogo, 5-94, Moscow 125319, Russia. olovnikov@dol.ru
D000375:Aging / Q000235:genetics* / Q000502:physiology; D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D044127:Epigenesis, Genetic; D005260:Female; D006112:Gravitation; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism; D016081:Moon; D010641:Phenotype; D010870:Pineal Gland / Q000166:cytology / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011247:Pregnancy; D016615:Telomere / Q000378:metabolism*
D013006:Growth Hormone; D004247:DNA