title: Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk.
abstract: Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied 67 adults with advanced periodontitis requiring full-mouth tooth extraction. Blood samples were obtained: (1) at initial presentation, immediately prior to treatment of presenting symptoms; (2) one to two weeks later, before all teeth were removed; and (3) 12 weeks after full-mouth tooth extraction. After full-mouth tooth extraction, there was a significant decrease in C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen, and white cell and platelet counts. This study shows that elimination of advanced periodontitis by full-mouth tooth extraction reduces systemic inflammatory and thrombotic markers of cardiovascular risk. Analysis of the data supports the hypothesis that treatment of periodontal disease may lower cardiovascular risk, and provides a rationale for further randomized studies.
authors.affiliation: Sydney Dental Hospital, 2 Chalmers Street, Surry Hills NSW 2010, Australia. barbara.taylor@email.cs.nsw.gov.au
authors.forename: B A
authors.initials: BA
authors.lastname: Taylor
authors.forename: G H
authors.initials: GH
authors.lastname: Tofler
authors.forename: H M R
authors.initials: HM
authors.lastname: Carey
authors.forename: M-C
authors.initials: MC
authors.lastname: Morel-Kopp
authors.forename: S
authors.initials: S
authors.lastname: Philcox
authors.forename: T R
authors.initials: TR
authors.lastname: Carter
authors.forename: M J
authors.initials: MJ
authors.lastname: Elliott
authors.forename: A D
authors.initials: AD
authors.lastname: Kull
authors.forename: C
authors.initials: C
authors.lastname: Ward
authors.forename: K
authors.initials: K
authors.lastname: Schenck
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D006973:Hypertension / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood*; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000628:therapy*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010976:Platelet Count; D012307:Risk Factors; D012907:Smoking / Q000097:blood; D013927:Thrombosis / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood; D014081:Tooth Extraction
chemical_list: D018836:Inflammation Mediators; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D002097:C-Reactive Protein; D010959:Tissue Plasminogen Activator