title: Dynamic transition in tRNA is solvent induced.
abstract: Dynamics of tRNA was studied using neutron scattering spectroscopy. Despite vast differences in the architecture and backbone structure of proteins and RNA, hydrated tRNA undergoes the dynamic transition at the same temperature as hydrated lysozyme. The similarity of the dynamic transition in RNA and proteins supports the idea that it is solvent induced. Because tRNA essentially has no methyl groups, the results also suggest that methyl groups are not the main contributor of the dynamic transition in biological macromolecules. However, they may explain strong differences in the dynamics of tRNA and lysozyme observed at low temperatures.
authors.affiliation: Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Caliskan
authors.forename: Robert M
authors.initials: RM
authors.lastname: Briber
authors.forename: D
authors.initials: D
authors.lastname: Thirumalai
authors.forename: Victoria
authors.initials: V
authors.lastname: Garcia-Sakai
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Woodson
authors.forename: Alexei P
authors.initials: AP
authors.lastname: Sokolov