title: Lung fibre burden in lung cancer cases employed in the rock and slag wool industry.
abstract: OBJECTIVE
  To evaluate the relationship between estimated exposure to man-made vitreous fibres (MMVF) and to asbestos fibres and their concentration in the lung tissue of lung cancer cases amongst MMVF production workers.
  
  
  METHODS
  Retrospective retrieval of available lung tissue specimens was conducted following a case-control study that assessed estimated occupational exposures of MMVF workers. Fibre recovery and analysis by transmission electron microscopy (TEM) were conducted to determine fibre type, fibre dimension and numbers per gram of dry lung tissue. For cases with detailed exposure data, geometric mean (GM) concentrations were compared across the exposure categories, and regression models were used to investigate the relationship between the lung fibres and the variables of estimated exposure, with and without additional variables that may affect fibre retention.
  
  
  RESULTS
  A total of 24 samples from 17 cases of lung cancer were available for analysis: MMVF were detected in all cases. Asbestos fibres were detected in 16. No difference or trend in GM MMVF concentration was observed across the estimated exposure categories. Odds ratio (OR) for MMVF g(-1) dry lung was 0.5 (95% confidence interval: 0.1-2.4) for the second, and 3.5 (0.6-18.9) for the third quartile of index of average exposure to MMVF in industry, compared with the first (lowest exposed) quartile (no cases in the highest quartile).
  
  
  CONCLUSIONS
  No observable relationship existed between estimated exposure and directly-measured lung fibres among this sample of cases. Retrospective specimen collection, intra-individual variability in fibre concentration, effect of unknown factors on fibre retention and small sample size militated against this study providing evidence for or against a relationship between estimated exposure and lung fibre concentrations.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: K
authors.initials: K
authors.lastname: Soldan
authors.forename: F D
authors.initials: FD
authors.lastname: Pooley
authors.forename: J
authors.initials: J
authors.lastname: Hansen
authors.forename: A
authors.initials: A
authors.lastname: Andersen
authors.forename: J
authors.initials: J
authors.lastname: Chang-Claude
authors.forename: G
authors.initials: G
authors.lastname: Ferro
authors.forename: H
authors.initials: H
authors.lastname: Ohgaki
authors.forename: B Guldhammer
authors.initials: BG
authors.lastname: Skov
authors.forename: J W
authors.initials: JW
authors.lastname: Cherrie
authors.forename: R
authors.initials: R
authors.lastname: Saracci
authors.forename: P
authors.initials: P
authors.lastname: Boffetta
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity; D001194:Asbestos / Q000032:analysis; D016022:Case-Control Studies; D002617:Chemical Industry; D004784:Environmental Monitoring / Q000379:methods; D006801:Humans; D008168:Lung / Q000737:chemistry*; D008175:Lung Neoplasms / Q000737:chemistry* / Q000209:etiology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D019016:Mineral Fibers / Q000032:analysis* / Q000633:toxicity; D009784:Occupational Diseases / Q000209:etiology / Q000378:metabolism*; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis
chemical_list: D000395:Air Pollutants, Occupational; D019016:Mineral Fibers; D001194:Asbestos