title: [Effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparticles].
abstract: OBJECTIVE
  To investigate effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparuicles.
  
  
  METHODS
  Solid lipid nanoparticles (SLN) of various sizes (150 nm, 500 nm and 1000 nm) using Compritol 888 ATO as the material and silymarin (SM) as a model drug were prepared. Silybinin concentration in plasma of rats were determined by RP-HPLC with UV detector. The main pharmacokinetic parameters were calculated by 3p97.
  
  
  RESULTS
  Results showed that the AUC of 150 nm SLN was 2.08 fold that of 500 nm SLN and 2.54 fold of 1000 nm SLN treated orally to rats (P < 0.05). The oral bioavailability of 150 nm SLN was remarkably higher than the other two size SLN.
  
  
  CONCLUSIONS
  This has important implications in designing of SM-SLN as a new oral drug delivery system.
authors.affiliation: Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China.
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Shi-xiang
authors.initials: SX
authors.lastname: Hou
authors.forename: Jian-fang
authors.initials: JF
authors.lastname: Feng
authors.forename: Ben-qin
authors.initials: BQ
authors.lastname: Cai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005079:Excipients; D005227:Fatty Acids; D005260:Female; D008297:Male; D020944:Silybum marianum / Q000737:chemistry; D049329:Nanostructures; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012838:Silymarin / Q000008:administration & dosage* / Q000302:isolation & purification / Q000493:pharmacokinetics
chemical_list: D004337:Drug Carriers; D005079:Excipients; D005227:Fatty Acids; D012838:Silymarin; C086409:glyceryl behenate