Phosphodiesterase 11: a brief review of structure, expression and function.
Phosphodiesterase 11 (PDE11) is the latest isoform of the phosphodiesterase family to be identified. Interest in PDE11 has increased recently because tadalafil, an oral phosphodiesterase 5 inhibitor, cross reacts with PDE11. The function of PDE11 remains largely unknown, but growing evidence points to a possible role in male reproduction. The published literature on PDE11 structure, function and expression is reviewed.
Makhlouf
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Department of Urology, University of Illinois at Chicago, Chicago, IL 60612-7316, USA. tonymakhlouf@yahoo.com
Kshirsagar
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Niederberger
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D000818:Animals; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction / Q000502:physiology
D010727:Phosphoric Diester Hydrolases