Poor outcome of adult acute lymphoblastic leukemia patients carrying the (1;19)(q23;p13) translocation.
The (1;19)(q23;p13) translocation, leading to the production of the E2A/PBX1 fusion transcript, is one of the most common translocations in pediatric B-lineage acute lymphoblastic leukemia (ALL). It was assumed to be associated with a poor clinical outcome, although intensive therapy and bone marrow transplantation have been shown to be able to overcome the negative prognostic impact. Only few data are available concerning t(1;19)(q23;p13) in adult ALL. In particular, the prognostic significance of this genetic aberration is not yet clear. We describe three cases of adult ALL carrying the t(1;19)(q23;p13), who were all characterized by an aggressive clinical course and short survival, and discuss the molecular features of the disease as recently identified by gene expression profiling.
Piccaluga
Pier Paolo
PP
Institute of Haematology and Medical Oncology 'L. and A. Serànoli', S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. ppicca@med.unibo.it
Malagola
Michele
M
Rondoni
Michela
M
Ottaviani
Emanuela
E
Testoni
Nicoletta
N
Laterza
Claudio
C
Visani
Giuseppe
G
Pileri
Stefano A
SA
Martinelli
Giovanni
G
Baccarani
Michele
M
D000328:Adult; D016026:Bone Marrow Transplantation; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D011379:Prognosis; D012008:Recurrence; D014178:Translocation, Genetic; D017211:Treatment Failure