Adoptive transfer of allogeneic antigen-specific T cells.
Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect.
Riddell
Stanley R
SR
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. sriddell@fhcrc.org
Bleakley
Marie
M
Nishida
Tetsuya
T
Berger
Carolina
C
Warren
Edus H
EH
D019264:Adoptive Transfer; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D020544:Graft vs Leukemia Effect / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D015778:Minor Histocompatibility Antigens / Q000276:immunology*
D007519:Isoantigens; D015778:Minor Histocompatibility Antigens