Kinase cogs go forward and reverse in the Wnt signaling machine.
An important link between Wnt binding at the cell surface and nuclear -catenin-TCF-dependent transcription has been made with the identification of kinases that promote the association of the Wnt receptor and -catenin turnover complexes. Surprisingly, the enzymes implicated had previously been suggested to inhibit rather than promote Wnt signaling.
Dale
Trevor
T
D000818:Animals; D007527:Isoenzymes / Q000378:metabolism; D010770:Phosphotransferases / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
D007527:Isoenzymes; D051153:Wnt Proteins; D010770:Phosphotransferases