title: ABS: a database of Annotated regulatory Binding Sites from orthologous promoters.
abstract: Information about the genomic coordinates and the sequence of experimentally identified transcription factor binding sites is found scattered under a variety of diverse formats. The availability of standard collections of such high-quality data is important to design, evaluate and improve novel computational approaches to identify binding motifs on promoter sequences from related genes. ABS (http://genome.imim.es/datasets/abs2005/index.html) is a public database of known binding sites identified in promoters of orthologous vertebrate genes that have been manually curated from bibliography. We have annotated 650 experimental binding sites from 68 transcription factors and 100 orthologous target genes in human, mouse, rat or chicken genome sequences. Computational predictions and promoter alignment information are also provided for each entry. A simple and easy-to-use web interface facilitates data retrieval allowing different views of the information. In addition, the release 1.0 of ABS includes a customizable generator of artificial datasets based on the known sites contained in the collection and an evaluation tool to aid during the training and the assessment of motif-finding programs.
authors.affiliation: Grup de Recerca en Informàtica Biomèdica, Institut Municipal d'Investigació Mèdica/Universitat Pompeu Fabra/Centre de Regulació Genòmica C/Doctor Aiguader 80, 08003 Barcelona, Spain. eblanco@imim.es
authors.forename: Enrique
authors.initials: E
authors.lastname: Blanco
authors.forename: Domènec
authors.initials: D
authors.lastname: Farré
authors.forename: M Mar
authors.initials: MM
authors.lastname: Albà
authors.forename: Xavier
authors.initials: X
authors.lastname: Messeguer
authors.forename: Roderic
authors.initials: R
authors.lastname: Guigó
mesh_terms: D000818:Animals; D001665:Binding Sites; D002645:Chickens / Q000235:genetics; D030561:Databases, Nucleic Acid; D023281:Genomics; D006801:Humans; D020407:Internet; D051379:Mice; D011401:Promoter Regions, Genetic; D051381:Rats; D014157:Transcription Factors / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D014157:Transcription Factors