Antimicrobial beta-peptoids by a block synthesis approach.
Antimicrobial peptides and their mimetics offer a potential new disinfective tool. beta-Peptoids (oligo-N-substituted beta-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-beta-peptoids were first prepared and then ligated via amide bond formation to synthesize larger beta-peptoids was developed. The beta-peptoids were found to possess moderate activity in an Escheridchia coli assay.
Shuey
Steven W
SW
DuPont Central Research and Development, PO Box 80328, Experimental Station, Wilmington, DE 19880-0328, USA. Steven.W.Shuey@usa.dupont.com
Delaney
William J
WJ
Shah
Mukesh C
MC
Scialdone
Mark A
MA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D034444:Peptoids