title: Epoxide hydrolases: structure, function, mechanism, and assay.
abstract: Epoxide hydrolases are a class of enzymes important in the detoxification of genotoxic compounds, as well as in the control of physiological signaling molecules. This chapter gives an overview on the function, structure, and enzymatic mechanism of structurally characterized epoxide hydrolases and describes selected assays for the quantification of epoxide hydrolase activity.
authors.affiliation: Institut fuer Pharmakologie und Toxikologie, Universitaet Wuerzburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Arand
authors.forename: Annette
authors.initials: A
authors.lastname: Cronin
authors.forename: Magdalena
authors.initials: M
authors.lastname: Adamska
authors.forename: Franz
authors.initials: F
authors.lastname: Oesch
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D004851:Epoxide Hydrolases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008658:Inactivation, Metabolic; D015394:Molecular Structure; D017510:Protein Folding; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D013229:Stearic Acids / Q000032:analysis / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D011994:Recombinant Proteins; D013229:Stearic Acids; D015262:Xenobiotics; C013519:9,10-epoxystearic acid; D004851:Epoxide Hydrolases; C043134:leukotriene A4 hydrolase