title: Analysis of heartbeat dynamics by point process adaptive filtering.
abstract: Heartbeats are a point process yet, most of the current analysis methods do not model this important characteristic of these data. We describe human heartbeat time series as a history dependent inverse Gaussian model. We present a point process adaptive filter algorithm to estimate the model's time-varying parameters, and use it to compute new measures of heart rate variability. We apply our algorithm to analyze simulated heartbeat data and actual heartbeat data from a tilt table experiment and from healthy subjects and subjects with congestive heart failure during sleep. Our results suggest a new approach for characterizing heartbeat dynamics.
authors.affiliation: Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston 02114-2696, USA. barbieri@neurostat.mgh.harvard.edu
authors.forename: Riccardo
authors.initials: R
authors.lastname: Barbieri
authors.forename: Emery N
authors.initials: EN
authors.lastname: Brown
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D015233:Models, Statistical; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted