[The expressions of survivin and VEGF in squamous cell carcinoma of larynx and the correlation between the two marks].
OBJECTIVE
To study the expressions and biological behavior of Survivin and VEGF in squamous cell carcinoma of larynx (LSCC) and the correlation between Survivin and VEGF.


METHODS
The expressions of Survivin and VEGF in LSCC tissues of 40 cases and normal mucosa of larynx tissues of 5 cases were studied by immunohistochemical staining.


RESULTS
The expressions of Survivin and VEGF in LSCC tissues were higher than those in normal mucosa of laryngeal cavity (P <0.01). The expressions of the two marks in LSCC with the metastasis of lymph nodes were higher than those without metastasis (Survivin: P <0.05, VEGF: P <0.01). Age and sex did not change the expressions obviously (P > 0.05). There was a negative correlation between T-stage and Survivin expressions (P < 0.05). There was also a negative correlation between T-stage and VEGF expressions (P < 0.05). But, there was a positive correlation in staining intensity between Survivin and VEGF (r = 0.676, P < 0.01).


CONCLUSIONS
Significant correlation between Survivin/VEGF expression and T-stage (P <0.05), lymph node metastasis (P <0.05) and prognosis (P <0.01) was revealed in squamous cell carcinoma of larynx. The high expression of it suggests bad prognosis. The up-regulate of the two genes suggest that they play important roles in the formation and metastasis of LSCC.
Wang
Yanjun
Y
Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
Kong
Weijia
W
Xiong
Xingao
X
Zhang
Song
S
Sun
Dawei
D
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D000077022:Survivin; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A