title: [Study on the anticancer activities of the Clematis manshrica saponins in vivo].
abstract: OBJECTIVE
  To study the anticancer activity of the Clematis manshrica saponins in vivo.
  
  
  METHODS
  Anticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo.
  
  
  RESULTS
  The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25% (P < 0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P < 0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39% (P < 0.05-0.01), respectively.
  
  
  CONCLUSIONS
  The results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.
authors.affiliation: College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Wang
authors.forename: Bao-Gui
authors.initials: BG
authors.lastname: Wang
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D039324:Clematis / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D007941:Leukemia P388 / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012503:Saponins / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000473:pathology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins