title: Power and sample size calculation of comparative diagnostic accuracy studies with multiple correlated test results.
abstract: We consider the power and sample size calculation of diagnostic studies with normally distributed multiple correlated test results. We derive test statistics and obtain power and sample size formulas. The methods are illustrated using an example of comparison of CT and PET scanner for detecting extra-hepatic disease for colorectal cancer.
authors.affiliation: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, 6100 Executive Blvd., Rockville, MD 20852, USA. liua@mail.nih.gov
authors.forename: Aiyi
authors.initials: A
authors.lastname: Liu
authors.forename: Enrique F
authors.initials: EF
authors.lastname: Schisterman
authors.forename: Madhu
authors.initials: M
authors.lastname: Mazumdar
authors.forename: Jiang
authors.initials: J
authors.lastname: Hu
mesh_terms: D001699:Biometry; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging; D019937:Diagnostic Techniques and Procedures / Q000706:statistics & numerical data*; D006801:Humans; D015233:Models, Statistical; D049268:Positron-Emission Tomography; D012372:ROC Curve; D018401:Sample Size; D014057:Tomography, X-Ray Computed