A highly selective synthesis of 3-hydroxy-2-methylpropionamide involving a one-pot tandem hydroformylation-hydrogenation sequence.
3-Hydroxy-2-methylpropionamide, an important intermediate in the synthesis of methyl methacrylate, has been obtained with excellent conversion and high selectivity from acrylamide by a tandem hydroformylation-hydrogenation sequence catalysed by Rh/PPh3 and Raney Ni, respectively.
García
Luis
L
Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, Campus Sescelades, Tarragona, Spain.
Claver
Carmen
C
Diéguez
Montserrat
M
Masdeu-Bultó
Anna M
AM
D020106:Acrylamide / Q000737:chemistry*; D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013696:Temperature
C518388:3-hydroxy-2-methylpropionamide; D000178:Acrylamides; D008024:Ligands; D009942:Organometallic Compounds; D020106:Acrylamide; D009532:Nickel; D012238:Rhodium