title: Thoracic radiotherapy for limited-stage small-cell lung cancer: controversies and future developments.
abstract: Thoracic radiotherapy has an established role in the management of limited-disease small-cell lung cancer (LD SCLC). However, essential questions relating to the optimisation of thoracic radiotherapy remain unanswered, including volume of irradiation, optimal total dose, fractionation, timing and sequencing of radiation. This review highlights the need for well-designed multi-national trials aimed at the optimisation and standardisation of radiotherapy for LD SCLC.
authors.affiliation: Clinical Oncology Department, Christie Hospital NHS Trust, Manchester, UK. corinne.finn@christie-tr.nwest.nhs.uk
authors.forename: C
authors.initials: C
authors.lastname: Faivre-Finn
authors.forename: L W
authors.initials: LW
authors.lastname: Lee
authors.forename: P
authors.initials: P
authors.lastname: Lorigan
authors.forename: C
authors.initials: C
authors.lastname: West
authors.forename: N
authors.initials: N
authors.lastname: Thatcher
mesh_terms: D018288:Carcinoma, Small Cell / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D013997:Time Factors