[Retinoblastoma].
Retinoblastomas are the most frequent intraocular tumors in childhood. Untreated, the tumor is almost always fatal. Using a multidisciplinary approach combining the efforts of ophthalmologists, radiation oncologists, pediatric oncologists and geneticists a survival rate of more than 95% can be achieved. Molecular genetic research on the origin of retinoblastomas has substantially helped in our understanding of the origin of malignant tumors in general, as well as to the key role of the Rb-1 gene as a tumor suppressor.
Bornfeld
N
N
Zentrum für Augenheilkunde, Universitätsklinikum Essen. retina@uni-essen.de
Schüler
A
A
Bölöni
R
R
Jurklies
C
C
Wieland
R
R
Sauerwein
W
W
Lohmann
D
D
D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D012175:Retinoblastoma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy*