Virucidal effect of lipids on visna virus, a lentivirus related to HIV.
Natural lipids and fatty alcohols show virucidal activities against enveloped viruses. A virucidal profile of these compounds against visna virus (VV), a lentivirus related to HIV, or against other viruses of the genus Lentivirus has not been established before and could help elucidate how lipids inactivate enveloped viruses and assist in the development of virucidal drugs. The activity profile for VV may not exactly reflect the profile for HIV or for the lentivirus subgroup in general, but the results for VV are in agreement with earlier studies, which have shown that lipids become generally more virucidal at low pH.
Hilmarsson
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Institute of Biology, University of Iceland, Reykjavik, Iceland. hilmarh@hi.is
Larusson
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LV
Thormar
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D000998:Antiviral Agents / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000494:pharmacology*; D050178:Monoglycerides / Q000494:pharmacology; D038301:Virus Inactivation; D014790:Visna-maedi virus / Q000187:drug effects*
D000998:Antiviral Agents; D005233:Fatty Alcohols; D008055:Lipids; D050178:Monoglycerides