Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16.
OBJECTIVE
To compare the fundus photographic and fluorescein angiographic features with the histologic findings in eyes from patients enrolled in the Submacular Surgery Trials (SST).


METHODS
Clinical trials with clinicopathologic correlation.


METHODS
Eyes that were obtained postmortem from patients who participated in the donor program were processed at the SST Pathology Center and examined histologically; the macular regions were reconstructed topographically with two-dimensional cartography. Fundus photographic and fluorescein angiographic features were correlated with the histopathologic and two-dimensional cartographic findings.


RESULTS
The eyes from two patients each from the SST Group N and B Trials were studied. The study eye of one patient that had been assigned randomly to observation contained a subretinal fibrovascular scar that corresponded to a histologic growth pattern of a thick, collagenized subretinal component combined with a subretinal pigment epithelium (subRPE) fibrovascular component. The study eye of the other patient who was assigned randomly to observation showed angiographic occult without classic choroidal neovascularization (CNV) that corresponded to subRPE CNV. The study eye of one patient who was assigned randomly to surgery showed an angiographic surgical defect without CNV and histologic retinal pigment epithelium (RPE)/photoreceptor atrophy that was associated with a thin layer of subRPE CNV. The study eye of the other patient who was assigned randomly to surgery showed an angiographic surgical defect with classic CNV that corresponded to histologic RPE/photoreceptor atrophy that was associated with subRPE fibrovascular tissue and subretinal CNV. Both surgical eyes contained linear breaks in Bruch's membrane that included chevron-shaped breaks.


CONCLUSIONS
Four SST study eyes that were examined postmortem contained CNV. The angiographic patterns and histologic features of the CNV support previous correlations of surgically excised CNV.
Grossniklaus
Hans E
HE
Department of Ophthalmology, Emory University School of Medicine, 428 Emory Eye Center, 1365 Clifton Road, Atlanta, GA 30322, USA. ophtheg@emory.edu
Wilson
David J
DJ
Bressler
Susan B
SB
Bressler
Neil M
NM
Toth
Cynthia A
CA
Green
W Richard
WR
Miskala
Päivi
P
D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D020256:Choroidal Neovascularization / Q000473:pathology* / Q000601:surgery; D005260:Female; D005355:Fibrosis; D005451:Fluorescein Angiography; D006801:Humans; D008266:Macula Lutea / Q000473:pathology* / Q000601:surgery; D008268:Macular Degeneration / Q000473:pathology* / Q000601:surgery; D008297:Male; D010781:Photography; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D016032:Randomized Controlled Trials as Topic; D014019:Tissue Donors