title: Alkaloid content of the seeds from Erythroxylum Coca var. Coca.
abstract: Alkaloid extracts from the seeds of Erythroxylum Coca var. Coca grown in the Chapare Valley of Bolivia were subjected to gas and liquid chromatographic-mass spectrometric analyses. Several alkaloids from these seeds were detected and characterized, including methylecgonidine, tropine, 3alpha-acetoxytropane, ecgonine methyl ester, cuscohygrine, N-norbenzoyltropine, benzoyltropine, hexanoylecgonine methyl ester, cocaine, cis-cinnamoylcocaine, and trans-cinnamoylcocaine. Methylecgonidine was determined to be the primary constituent and not an analytical artifact. Additionally, two significant new uncharacterized alkaloids were established as present. Recent evidence suggests that some cocaine processors are adding this seed extraction material to cocaine extracted from coca leaf and may impact cocaine impurity signature profiles.
authors.affiliation: Special Testing and Research Laboratory, Drug Enforcement Administration. U.S. Department of Justice, Dulles, VA 20166-9509, USA.
authors.forename: John F
authors.initials: JF
authors.lastname: Casale
authors.forename: Steven G
authors.initials: SG
authors.lastname: Toske
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Colley
mesh_terms: D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry; D002099:Cacao / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry*
chemical_list: D000470:Alkaloids