Congenital uveal malignant melanoma: a case report.
We present a case of congenital choroidal mass in a male infant with multiple cutaneous pigmented lesions. Enucleation performed in the first weeks of life confirmed the diagnosis of diffuse uveal malignant melanoma with extraocular extension. The patient was also treated with 5 cycles of chemotherapy. He subsequently developed cutaneous and ocular pigmented lesions, including 2 choroidal nevi located within the posterior pole and a benign conjunctival lesion in the opposite eye, in addition to malignant melanoma of the skin.



At 10 years follow-up, the child is clinically well with no evidence of further malignancy. We believe this represents the fourth case ever reported in the literature and the longest follow-up of a congenital malignant melanoma originating within the eye.
Palazzi
Maristela A
MA
The Boldrini Children Center, Campinas, Brazil. palazzi@lexxa.com.br
Ober
Michael D
MD
Abreu
Helio F H
HF
Cardinalli
Izilda A
IA
Isaac
Cassiano R
CR
Odashiro
Alexandre N
AN
Burnier
Miguel N
MN
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D015353:Eye Enucleation; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008545:Melanoma / Q000151:congenital* / Q000188:drug therapy / Q000556:secondary; D009361:Neoplasm Invasiveness; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*; D014604:Uveal Neoplasms / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use
D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide