title: Cytotoxic flavonoids and new chromenes from Ficus formosana f. formosana.
abstract: Two new chromenes, ficuformodiol A and ficuformodiol B, and nine known compounds including one chromene, spatheliachromen, six flavonoids, obovatin, carpachromene ( 5), apigenin ( 6), norartocarpetin ( 7), steppogenin, 6-prenylpinocembrin, one benzopyran, chromenylacrylic acid, and one isocoumarin, ( R)-(-)-mellein, were obtained from the cytotoxic chloroform-soluble fraction of the stems of Ficus formosana f. formosana (Moraceae). Their structures were determined by means of spectroscopic analyses. Compounds 5, 6 and 7 exhibited significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines in vitro.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Sheu
authors.forename: Lien-Chai
authors.initials: LC
authors.lastname: Chiang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Chen
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D030681:Ficus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D005419:Flavonoids