title: 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.
abstract: High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
authors.affiliation: Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. klopfenstein.sr@pg.com
authors.forename: Sean R
authors.initials: SR
authors.lastname: Klopfenstein
authors.forename: Artem G
authors.initials: AG
authors.lastname: Evdokimov
authors.forename: Anny-Odile
authors.initials: AO
authors.lastname: Colson
authors.forename: Neil T
authors.initials: NT
authors.lastname: Fairweather
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Neuman
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Maier
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Gray
authors.forename: Gina S
authors.initials: GS
authors.lastname: Gerwe
authors.forename: George E
authors.initials: GE
authors.lastname: Stake
authors.forename: Brian W
authors.initials: BW
authors.lastname: Howard
authors.forename: Julie A
authors.initials: JA
authors.lastname: Farmer
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Pokross
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Downs
authors.forename: Bhavani
authors.initials: B
authors.lastname: Kasibhatla
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Peters
mesh_terms: D001665:Binding Sites; D001667:Binding, Competitive; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D018716:Molecular Mimicry; D019000:Phosphotyrosine / Q000378:metabolism; D011485:Protein Binding; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D018909:src Homology Domains
chemical_list: D004791:Enzyme Inhibitors; D008024:Ligands; D013451:Sulfonic Acids; D044005:Tetrahydroisoquinolines; D019000:Phosphotyrosine; C014843:1,2,3,4-tetrahydroisoquinoline; C005741:sulfamic acid; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases