Autologous peripheral blood stem cell transplantation for POEMS syndrome.
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
Kuwabara
S
S
Department of Neurology, Chiba University School of Medicine, Japan. kuwabara-s@faculty.chiba-u.jp
Misawa
S
S
Kanai
K
K
Kikkawa
Y
Y
Nishimura
M
M
Nakaseko
C
C
Cho
R K
RK
Hattori
T
T
D000328:Adult; D000368:Aged; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use*; D016878:POEMS Syndrome / Q000503:physiopathology / Q000628:therapy*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D010954:Plasmacytoma / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism
D019653:Myeloablative Agonists; D042461:Vascular Endothelial Growth Factor A; D008558:Melphalan