Domain growth, budding, and fission in phase-separating self-assembled fluid bilayers.
A systematic investigation of the phase-separation dynamics in self-assembled binary fluid vesicles and open membranes is presented. We use large-scale dissipative particle dynamics to explicitly account for solvent, thereby allowing for numerical investigation of the effects of hydrodynamics and area-to-volume constraints. In the case of asymmetric lipid composition, we observed regimes corresponding to coalescence of flat patches, budding, vesiculation, and coalescence of caps. The area-to-volume constraint and hydrodynamics have a strong influence on these regimes and the crossovers between them. In the case of symmetric mixtures, irrespective of the area-to-volume ratio, we observed a growth regime with an exponent of 1/2. The same exponent is also found in the case of open membranes with symmetric composition.
Laradji
Mohamed
M
Department of Physics, The University of Memphis, Tennessee 38152, USA. mlaradji@memphis.edu
Sunil Kumar
P B
PB
D000465:Algorithms; D002627:Chemistry, Physical / Q000379:methods*; D003198:Computer Simulation; D008051:Lipid Bilayers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008566:Membranes / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D015233:Models, Statistical; D008962:Models, Theoretical; D008968:Molecular Conformation; D016011:Normal Distribution; D012984:Software; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
D008051:Lipid Bilayers; D008055:Lipids; D012997:Solvents