title: Antifungal flavonoids from Hildegardia barteri.
abstract: A new isoflavan, (3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan, hildegardiol (1), and two known flavonoids, 2-hydroxymaackiain (2) and farrerol (3), were isolated from the antifungal root extract of Hildegardia barteri. The pterocarpan 2 was largely responsible for the observed antifungal activity.
authors.affiliation: Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA.
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Meragelman
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Tucker
authors.forename: Thomas G
authors.initials: TG
authors.lastname: McCloud
authors.forename: John H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: Robert H
authors.initials: RH
authors.lastname: Shoemaker
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019660:Malvaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013636:Tanzania
chemical_list: C506996:(3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan; D000935:Antifungal Agents; D002867:Chromones; D005419:Flavonoids; D007529:Isoflavones; C015881:farrerol