title: Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: a study of structure-activity relationships and molecular mechanism.
abstract: The inhibition of lipopolysaccharide-induced NOS by 19 bis(bibenzyls) isolated from liverworts in RAW 264.7 macrophages was evaluated. The presence of phenolic hydroxyls and saturation at 7,8 and/or 7'/8' are required for inhibition of NO production. Among the compounds tested, marchantin A was the most potent, and its inhibitory activity was consistent with the inhibition of LPS-induced iNOS mRNA.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Dang Ngoc
authors.initials: DN
authors.lastname: Quang
authors.forename: Nishizawa
authors.initials: N
authors.lastname: Takeshi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Chie
authors.initials: C
authors.lastname: Kohchi
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Soma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D000818:Animals; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035926:Hepatophyta / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000201:enzymology*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D013329:Structure-Activity Relationship
chemical_list: D001632:Bibenzyls; D004988:Ethers, Cyclic; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D009569:Nitric Oxide; C096123:marchantin A; D052247:Nitric Oxide Synthase Type II