title: Emerin increase in regenerating muscle fibers.
abstract: The fate of emerin during skeletal muscle regeneration was investigated in an animal model by means of crush injury. Immunofluorescence, immunoblotting and mRNA analysis demonstrated that emerin level is increased in regenerating rat muscle fibers with respect to normal mature myofibers. This finding suggests an involvement of emerin during the muscle fiber regeneration process, in analogy with its reported involvement in muscle cell differentiation in vitro. The impairment of skeletal muscle physiological regeneration or reorganization could be a possible pathogenetic mechanism for Emery Dreifuss muscular dystrophy.
authors.affiliation: ITOI-CNR, Unit of Bologna c/o Istituti Ortopedici Rizzoli, Bologna, Italy. squarzoni@area.bo.cnr.it
authors.forename: S
authors.initials: S
authors.lastname: Squarzoni
authors.forename: P
authors.initials: P
authors.lastname: Sabatelli
authors.forename: C
authors.initials: C
authors.lastname: Capanni
authors.forename: G
authors.initials: G
authors.lastname: Lattanzi
authors.forename: C
authors.initials: C
authors.lastname: Rutigliano
authors.forename: M
authors.initials: M
authors.lastname: Columbaro
authors.forename: E
authors.initials: E
authors.lastname: Mattioli
authors.forename: M
authors.initials: M
authors.lastname: Rocca
authors.forename: N M
authors.initials: NM
authors.lastname: Maraldi
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D015151:Immunoblotting; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D023421:Models, Animal; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D032446:Myoblasts / Q000166:cytology / Q000378:metabolism; D009687:Nuclear Proteins; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology*; D013946:Thymopoietins / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D008565:Membrane Proteins; D009687:Nuclear Proteins; D012333:RNA, Messenger; D013946:Thymopoietins; C092710:emerin