[Apoptosis mononuclear cells in sarcoidosis].
Sarcoidosis (SA) is a systemic granulomatous disorder of unknown etiology. The diagnosis is firmly established when clinicoradiological findings are supported by histological evidence of noncaseating epithelioid cell granulomas found on tissue biopsy Diagnosis of SA requires exclusion of other causes of granuloma formation, first of all Mycobacterium tuberculosis. Sarcoidosis is a disease known to be associated with various immunological alterations, including depression of cutaneous delayed-type hypersensitivity and an activation of monocytes/macrophages and a heightened helper T cell type 1 immune response at sites of disease but the mechanism leading to the persistent accumulation of inflammatory cells is not understood. In some studies, apoptosis is considered as factor in pathogenesis of sarcoid and tuberculous granuloma. Apoptosis--programmed cell death is a genetically encoded cell elimination program which ensures equilibrium between cell proliferation and cell death and by which crippled, useless or infected cells are eliminated as part of normal physiology. Aberrations in signalling, in receptors or alterations in mechanism of apoptosis are involved in the occurrence of tuberculosis. To date, there are a few of papers concerning alternations of apoptosis of peripheral and alveolar mononuclear cells in sarcoidosis have been published but the results have been controversial.
Dubaniewicz
Anna
A
Akademia Medyczna w Gdańsku, Katedra i Zakład Fizjopatologii.
Dubaniewicz
Ada
A
D017209:Apoptosis; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000473:pathology; D012507:Sarcoidosis; D017565:Sarcoidosis, Pulmonary / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D014376:Tuberculosis / Q000276:immunology* / Q000473:pathology