title: Supraesophageal reflux: validation of a symptom questionnaire.
abstract: OBJECTIVE
  To develop and validate a questionnaire for supraesophageal manifestations of reflux (SER) that will facilitate its study in clinical and research settings.
  
  
  METHODS
  The Supraesophageal Reflux Questionnaire (SERQ) and previously validated Reflux Symptom Index (RSI) were subjected to multiple types of validity testing, including content validity, concurrent validity, reproducibility, and predictive validity.
  
  
  RESULTS
  The concurrent validity and reproducibility of both instruments was good to excellent for most items tested. The predictive validity of the SERQ was superior to the RSI when it included the covariates of history of sinusitis, use of over-the-counter antacid medications, age, gender, and body mass index.
  
  
  CONCLUSIONS
  The SERQ will serve as both a useful clinical and research tool by offering not only SER symptom information, like the RSI, but also information about the patient's medical history and medication usage that will facilitate use of the SERQ in research protocols.
  
  
  METHODS
  B-2b.
authors.affiliation: Department of Otolaryngology, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: E
authors.initials: E
authors.lastname: Dauer
authors.forename: D
authors.initials: D
authors.lastname: Thompson
authors.forename: A R
authors.initials: AR
authors.lastname: Zinsmeister
authors.forename: R
authors.initials: R
authors.lastname: Dierkhising
authors.forename: A
authors.initials: A
authors.lastname: Harris
authors.forename: T
authors.initials: T
authors.lastname: Zais
authors.forename: J
authors.initials: J
authors.lastname: Alexander
authors.forename: J A
authors.initials: JA
authors.lastname: Murray
authors.forename: J L
authors.initials: JL
authors.lastname: Wise
authors.forename: K
authors.initials: K
authors.lastname: Lim
authors.forename: G R
authors.initials: GR
authors.lastname: Locke
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Romero
mesh_terms: D000863:Antacids / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D006305:Health Status Indicators; D006801:Humans; D008487:Medical History Taking; D010342:Patient Acceptance of Health Care; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D000863:Antacids; D000897:Anti-Ulcer Agents