title: Selective diethylzinc reduction of imines in the presence of ketones catalyzed by Ni(acac)2.
abstract: A selective reduction method of an electronically deficient imine in the presence of ketone was developed by employing Et(2)Zn and 5 mol % of Ni(acac)(2). The method was applied in the reduction of S(S)-tert-butanesulfinyl ketimines 1 to afford amines 2 in 23-92% yields and 73:27 to 98:2 diastereoselectivities. A plausible mechanism was proposed on the basis of an NMR study.
authors.affiliation: Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chendu, PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xiao
authors.forename: Haowei
authors.initials: H
authors.lastname: Wang
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Bian
authors.forename: Yong
authors.initials: Y
authors.lastname: Qin