title: Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles.
abstract: A number of fluorinated 1-aryl-tetrahydrocyclopentapyrazoles were synthesized and their insecticidal activity was evaluated. Some of the fluorinated compounds had significant insecticidal properties.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, 665 Stockton Drive, Suite 104, Exton, PA 19341, USA. smeegall@prdus.jnj.com
authors.forename: Sanath K
authors.initials: SK
authors.lastname: Meegalla
authors.forename: Dario
authors.initials: D
authors.lastname: Doller
authors.forename: Ruiping
authors.initials: R
authors.lastname: Liu
authors.forename: DeYou
authors.initials: D
authors.lastname: Sha
authors.forename: YuKai
authors.initials: Y
authors.lastname: Lee
authors.forename: Richard M
authors.initials: RM
authors.lastname: Soll
authors.forename: Nancy
authors.initials: N
authors.lastname: Wisnewski
authors.forename: Gary M
authors.initials: GM
authors.lastname: Silver
authors.forename: Dale
authors.initials: D
authors.lastname: Dhanoa
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002462:Cell Membrane / Q000378:metabolism; D006793:Houseflies / Q000187:drug effects / Q000254:growth & development; D007313:Insecta / Q000187:drug effects*; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011869:Radioligand Assay; D018079:Receptors, GABA / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007306:Insecticides; D011720:Pyrazoles; D018079:Receptors, GABA; C091518:1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane