Hemodynamic and electrophysiological relationship involved in human face processing: evidence from a combined fMRI-ERP study.
Functional magnetic resonance imaging (fMRI) and event-related potential (ERP) experiments were conducted in the same group of subjects and with an identical task paradigm to investigate a possible relationship between hemodynamic and electrophysiological responses within the brain. The subjects were instructed to judge whether visually presented stimuli were faces or houses and then press the corresponding button. Functional MRI identified face- and house-related regions in the lateral and medial part of the fusiform gyrus, respectively, while ERP showed significantly greater N170 negativity for face than for house stimuli in the temporo-occipital electrodes. Correlation analysis between the BOLD signal in the fusiform gyrus and ERP parameters demonstrated a close relationship between the signal and both latency and amplitude of N170 across the subjects. These correlations may indicate that the variation in cognitive demand and hemodynamic responses during the face/house discrimination task is coupled with the variation of N170 peak latency/amplitude across the subjects. Thus, integrative analysis of spatial and temporal information obtained from the two experimental modalities may help in studying neural correlates involved in a particular cognitive task.
Iidaka
Tetsuya
T
Department of Psychology, Nagoya University, Graduate School of Environmental Studies, Chikusa, Nagoya, Aichi 464-8601, Japan. iidaka@info.human.nagoya-u.ac.jp
Matsumoto
Atsushi
A
Haneda
Kaoruko
K
Okada
Tomohisa
T
Sadato
Norihiro
N
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003071:Cognition / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005145:Face; D005149:Facial Expression; D005260:Female; D005556:Form Perception / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008606:Mental Processes / Q000502:physiology; D010775:Photic Stimulation; D012016:Reference Values; D013702:Temporal Lobe / Q000098:blood supply / Q000502:physiology*