Effect of methisoprinol and KLP-602 on virus replication in chicken embryos.
The aim of the present study was to examine the effects of two immunomodulators (KLP-602 and Methisoprinol) on the proliferation of two strains of Newcastle disease virus in chick embryos. The effect of the maximum tolerable doses of both drugs (Methisoprinol--6 mg/embryo, KLP-602--5 mg/embryo) on lymphocyte reactivity were determined prior to the experiment. Both drugs inhibited the replication of the Roakin strain of NDV in various experimental designs, but neither of them affected the proliferation of the LaSota strain of NDV.
Małaczewska
J
J
Department of Infectious and Invasive Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland. stenia@uwm.edu.pl
Rotkiewicz
Z
Z
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D007542:Inosine Pranobex / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D009113:Muramidase / Q000494:pharmacology*; D009522:Newcastle disease virus / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; C488571:KLP602; D009113:Muramidase; D007542:Inosine Pranobex