title: Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.
abstract: Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic changes; however, until now, there has been no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University of Pennsylvania, was held from December 1 to 3, 2004 with the goal of establishing an internationally accepted uniform nomenclature for the pathology of genetically engineered mouse models of pancreatic exocrine neoplasia. The pancreatic pathology in 12 existing mouse models of pancreatic neoplasia was reviewed at this workshop, and a standardized nomenclature with definitions and associated images was developed. It is our intention that this nomenclature will standardize the reporting of genetically engineered mouse models of pancreatic exocrine neoplasia, that it will facilitate comparisons between genetically engineered mouse models and human pancreatic disease, and that it will be broad enough to accommodate newly emerging mouse models of pancreatic neoplasia.
authors.affiliation: Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. rhruban@jhmi.edu
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
authors.forename: N Volkan
authors.initials: NV
authors.lastname: Adsay
authors.forename: Jorge
authors.initials: J
authors.lastname: Albores-Saavedra
authors.forename: Miriam R
authors.initials: MR
authors.lastname: Anver
authors.forename: Andrew V
authors.initials: AV
authors.lastname: Biankin
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Boivin
authors.forename: Emma E
authors.initials: EE
authors.lastname: Furth
authors.forename: Toru
authors.initials: T
authors.lastname: Furukawa
authors.forename: Alison
authors.initials: A
authors.lastname: Klein
authors.forename: David S
authors.initials: DS
authors.lastname: Klimstra
authors.forename: Gunter
authors.initials: G
authors.lastname: Kloppel
authors.forename: Gregory Y
authors.initials: GY
authors.lastname: Lauwers
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Longnecker
authors.forename: Jutta
authors.initials: J
authors.lastname: Luttges
authors.forename: Anirban
authors.initials: A
authors.lastname: Maitra
authors.forename: G Johan A
authors.initials: GJ
authors.lastname: Offerhaus
authors.forename: Lucía
authors.initials: L
authors.lastname: Pérez-Gallego
authors.forename: Mark
authors.initials: M
authors.lastname: Redston
authors.forename: David A
authors.initials: DA
authors.lastname: Tuveson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005818:Genetic Engineering; D006801:Humans; D051379:Mice; D046790:Pancreas, Exocrine / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology*; D009626:Terminology as Topic