[Safety and effectiveness of opiate antagonist detoxification under general anesthesia].
OBJECTIVE
To evaluate safety and effectiveness of opiate antagonist detoxification under general anesthesia according to available prospective and retrospective data.


METHODS
We analyzed all detoxification cases that were performed in Vilnius University Emergency Hospital in the period of 2002-2005. Data of 65 patients from prospective, randomized, double-blind, placebo-controlled study and 21 retrospective cases were included in the study.


RESULTS
Full opiate receptor blockade was achieved in 85 cases (98.84%). No complications related to detoxification procedure or general anesthesia were recorded. Differences in procedure protocols and possible implications for clinical practice are discussed.


CONCLUSIONS
The protocol of the prospective study may be recommended as a safe and effective detoxification method.
Ivaskevicius
Juozas
J
Clinic of Anesthesiology and Intensive Care, Vilnius University, Siltnamiu 29, 04130 Vilnius, Lithuania.
Jovaisa
Tomas
T
Laurinenas
Giedrius
G
Vosylius
Saulius
S
Sipylaite
Jūrate
J
Badaras
Robertas
R
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D000931:Antidotes; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D010919:Placebos; D011446:Prospective Studies; D011957:Receptors, Opioid / Q000187:drug effects; D012449:Safety; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
D000931:Antidotes; D009292:Narcotic Antagonists; D010919:Placebos; D011957:Receptors, Opioid; D009271:Naltrexone