title: Anaplastic thyroid carcinoma associated with granulocyte colony-stimulating factor: report of a case.
abstract: A 75-year-old woman was hospitalized due to a right axillary mass. She had undergone a resection of thyroid carcinoma 13 years earlier, followed by two subsequent operations for recurrent thyroid disease. A physical examination revealed a right axillary mass associated with skin ulceration. Persistent bleeding was observed at the skin ulcer associated with the right axillary lymph node, despite conservative treatment for the lesion. Surgery was thus performed to control persistent bleeding from the axillary ulcer, and a histopathological examination resulted in a diagnosis of poorly differentiated thyroid carcinoma. The postoperative course was uneventful, but marked leukocytosis and extensive skin metastases were recognized 30 days postoperatively. A systemic examination revealed no other lesions associated with marked leukocytosis, but elevated levels of granulocyte colony-stimulating factor were noted in a blood examination. As a result, her general condition deteriorated rapidly and the patient died 2 weeks after the onset of leukocytosis.
authors.affiliation: Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Fujita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ogasawara
authors.forename: Minoru
authors.initials: M
authors.lastname: Naito
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Doihara
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D000368:Aged; D002291:Carcinoma, Papillary / Q000150:complications* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D007964:Leukocytosis / Q000209:etiology* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor