Receptor-mediated actions of renin and prorenin.
Renin can induce renal disease by generating angiotensin II and, thereby, increasing fibrosis. Huang et al describe a new mechanism of action whereby the renin-angiotensin system can also exert this effect. Direct activation of the renin/prorenin receptor in mesangial cells induced synthesis of TGF-beta and profibrotic proteins. Hence, like other proteases such as thrombin, renin and prorenin are capable of receptor-mediated cellular signaling.
Oliver
J A
JA
Columbia University, Department of Medicine, New York 10032, USA. Jao7@columbia.edu
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis; D005920:Glomerular Mesangium / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology*; D012083:Renin / Q000494:pharmacology*; D012084:Renin-Angiotensin System / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*; D053773:Transforming Growth Factor beta1; D025262:Vacuolar Proton-Translocating ATPases / Q000502:physiology*; D000093342:Prorenin Receptor
D000804:Angiotensin II; D016326:Extracellular Matrix Proteins; D011956:Receptors, Cell Surface; D012083:Renin; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D025262:Vacuolar Proton-Translocating ATPases; C458319:ATP6AP2 protein, human; D000093342:Prorenin Receptor; C508960:TGFB1 protein, human; C508962:Tgfb1 protein, rat