title: TRANSPATH: an information resource for storing and visualizing signaling pathways and their pathological aberrations.
abstract: TRANSPATH is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating between reactions that are evidenced by individual publications, generalizations of these reactions to construct species-independent 'reference pathways' and the 'semantic projections' of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuildertrade mark. The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH Public 6.0 is freely accessible for users from non-profit organizations under http://www.gene-regulation.com/pub/databases.html.
authors.affiliation: BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenbüttel, Germany. mathias.krull@biobase-international.com
authors.forename: Mathias
authors.initials: M
authors.lastname: Krull
authors.forename: Susanne
authors.initials: S
authors.lastname: Pistor
authors.forename: Nico
authors.initials: N
authors.lastname: Voss
authors.forename: Alexander
authors.initials: A
authors.lastname: Kel
authors.forename: Ingmar
authors.initials: I
authors.lastname: Reuter
authors.forename: Deborah
authors.initials: D
authors.lastname: Kronenberg
authors.forename: Holger
authors.initials: H
authors.lastname: Michael
authors.forename: Knut
authors.initials: K
authors.lastname: Schwarzer
authors.forename: Anatolij
authors.initials: A
authors.lastname: Potapov
authors.forename: Claudia
authors.initials: C
authors.lastname: Choi
authors.forename: Olga
authors.initials: O
authors.lastname: Kel-Margoulis
authors.forename: Edgar
authors.initials: E
authors.lastname: Wingender
mesh_terms: D003196:Computer Graphics; D030541:Databases, Genetic; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020407:Internet; D009154:Mutation; D010641:Phenotype; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000235:genetics; D014584:User-Computer Interface