title: [Effect of Laminaria japonica polysaccharides on lowing serum lipid and anti-atherosclerosis in hyperlipemia quails].
abstract: OBJECTIVE
  To study the effect of Laminaria Japonica Polysaccharides on lowing serum lipid and anti-atherosclerosis in quails.
  
  
  METHODS
  The hyperlipemia atherosclerosis (As) models of quails were induced by high lipids. After administration with Laminaria Japonica Polysccharides for two weeks, the content of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) in serum and the ratio of HDL/TC were determined, index of liver was calculated, the extent of aortic atherosclerosis and the atherosclerotic lesion were observed.
  
  
  RESULTS
  The concentration of TC, TG, LDL in serum and index of liver decreased remarkedly, the ratio of HLD/TC increased remarkably, the the extent of aortic atherosclerosis and the atherosclerotic lesion lightened obviously.
  
  
  CONCLUSIONS
  Laminaria Japonica Polysaccharides can effectively decrease the serum lipid and prevent the formation of atherosclerosis.
authors.affiliation: School of Pharmacy, Yantai University, Yantai, Shandong.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Gao
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Wenhua
authors.initials: W
authors.lastname: Shi
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology*; D001835:Body Weight / Q000187:drug effects; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007795:Laminaria / Q000737:chemistry*; D008055:Lipids / Q000097:blood*; D008148:Lovastatin / Q000494:pharmacology; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D011784:Quail
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D011134:Polysaccharides; D008148:Lovastatin