Modified alpha-beta chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine exhibited improved and stereo-nonspecific triplex-forming ability.
Novel alpha-beta chimeric oligonucleotides bearing a propionic acid derivative of an anthraquinone-polyamine conjugate in the "linker" region sequence-specifically formed a substantially stable alternate-stranded triplex with dsDNA almost regardless of the stereochemistry of the derivative.
Azam
A T M Zafrul
AT
Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan.
Moriguchi
Tomohisa
T
Shinozuka
Kazuo
K
D000880:Anthraquinones / Q000737:chemistry*; D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D006880:Hydroxy Acids; D007364:Intercalating Agents / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry* / Q000235:genetics; D011073:Polyamines / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
D000880:Anthraquinones; D006880:Hydroxy Acids; D007364:Intercalating Agents; D009841:Oligonucleotides; D011073:Polyamines; D011422:Propionates; C051802:triplex DNA; C110034:2,2-bis(hydroxymethyl)-propionic acid; D004247:DNA