Human microsomal prostaglandin E synthase 1: a member of the MAPEG protein superfamily.
In this chapter, we briefly review the MAPEG superfamily (membrane associated proteins in eicosanoid and glutathione metabolism), a family of proteins in which all human members except one possess glutathione conjugating capacity. Recent findings regarding the biological functions of MAPEG proteins are highlighted. More extensively, the characterization of human microsomal prostaglandin E synthase 1 is presented, including results and applied methodology.
Pettersson
Pär L
PL
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Thorén
Staffan
S
Jakobsson
Per-Johan
PJ
D005978:Glutathione / Q000378:metabolism; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology*; D015394:Molecular Structure; D005810:Multigene Family; D000071876:Prostaglandin-E Synthases
D007527:Isoenzymes; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases; D005978:Glutathione