Microwave-assisted parallel synthesis of a 14-helical beta-peptide library.
To facilitate the preparation of beta-peptide libraries in parallel, we have adapted reaction conditions for the solid-phase synthesis of 14-helical beta-peptides for use in a multimode microwave reactor. The low temperature/pressure requirements of microwave-assisted beta-peptide synthesis were found to be compatible with multiwell filter plates composed of polypropylene. Microwave heating of the 96-well plate was sufficiently homogeneous to allow the rapid preparation of a beta-peptide library in acceptable purity.
Murray
Justin K
JK
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Gellman
Samuel H
SH
D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods; D006860:Hydrogen Bonding; D008872:Microwaves; D015394:Molecular Structure; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary
D019151:Peptide Library; D010455:Peptides