Microbiological outcomes in women with diabetes and untreated asymptomatic bacteriuria.
BACKGROUND
Asymptomatic bacteriuria is common in diabetic women. Treatment of asymptomatic bacteriuria is not beneficial, but the natural history of the microbiology of asymptomatic bacteriuria has not been well described.


OBJECTIVE
To describe the microbiological outcomes of bacteriuria in diabetic women with untreated asymptomatic bacteriuria.


METHODS
Study subjects were initially identified through ambulatory endocrinology clinics. They were enrolled if they had two positive urine cultures > or = 10(8) cfu/l with the same organism within 2 weeks and no symptoms referable to urinary tract infection. Women initially received a 2-week course of placebo with follow-up cultures obtained at the end of treatment and 4 weeks post-treatment. Subsequently, the prevalence of bacteriuria was determined with urine cultures obtained every 3 months to a maximum of 36 months. Outcomes at yearly intervals were designated as one of: persistent bacteriuria; spontaneous resolution; resolution with antibiotics for symptomatic urinary infection; or resolution with antibiotics given for other indications. Women with and without persistent or frequent bacteriuria were compared to identify variables associated with bacteriuria.


RESULTS
The prevalence of bacteriuria in the study cohort declined to about 50% by 9 months, and subsequently remained stable throughout 3 years follow-up. Almost 20% of subjects remained bacteriuric with the original infecting organism throughout the period of observation. With evaluation at 12-month intervals, approximately one-quarter of subjects had each of the four potential outcomes of: resolution following antibiotic therapy for symptomatic urinary infection, following antibiotic therapy for other indications, spontaneous resolution without antibiotics, and persistent bacteriuria with the same organism. Women infected with gram-negative organisms were more likely to have persistent bacteriuria. Many women with resolution of initial bacteriuria, with or without antibiotics, became bacteriuric again during follow-up.


CONCLUSIONS
Women with asymptomatic bacteriuria and diabetes tend to have persistent or recurrent asymptomatic bacteriuria. Bacteriuria is benign, and seldom permanently eradicable.
Nicolle
L E
LE
Section of Infectious Diseases, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada. lnicolle@hsc.mb.ca
Zhanel
G G
GG
Harding
G K M
GK
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage; D001437:Bacteriuria / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D016001:Confidence Intervals; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D010919:Placebos / Q000008:administration & dosage*; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D016482:Urinalysis; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*
D000892:Anti-Infective Agents, Urinary; D010919:Placebos