Antianxiety effects of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice.
This work presents the behavioral effects of riparin I (methyl ether of N-benzoyl tyramine) from unripe fruit of Aniba riparia (Lauraceae) on the elevated plus maze, open field, rota rod and hole board tests in mice. Riparin I was administered acutely by intraperitoneal (i.p.) and oral routes to male mice at doses of 25 and 50 mg/kg. The results showed that riparin I (25 and 50 mg/kg, i.p. and per os) increased the number of entries and the time of permanence in the open arms in the plus maze test. Similarly, in the hole board test, riparin I in both routes increased the number of head dips. Riparin I with both doses and routes had no effects on spontaneous motor activity in mice or in the rota rod test, but decreased the number of groomings. These results showed that riparin I by both administration routes has effects on the central nervous system with antianxiety effects on the plus maze and hole board tests. The substance is devoid of myorelaxant effects.
de Sousa
Francisca Cléa Florenço
FC
Department of Physiology and Pharmacology, Federal University of Ceará, Brazil. clea@ufc.br
Monteiro
Andreisa Paiva
AP
de Melo
Carla Thiciane Vasconcelos
CT
de Oliveira
Glício Rebouças
GR
Vasconcelos
Silvânia Maria Mendes
SM
de França Fonteles
Marta Maria
MM
Gutierrez
Stanley Juan Chavez
SJ
Barbosa-Filho
José Maria
JM
Viana
Glauce Socorro Barros
GS
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D005638:Fruit; D019770:Lauraceae; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001549:Benzamides; D010936:Plant Extracts; C087987:riparin III; D003975:Diazepam; D014439:Tyramine