Gallbladder cancer in a patient with Miller-Dieker syndrome.
We report the case of a male patient with Miller-Dieker syndrome (MDS) and gallbladder cancer. Chromosome analysis by fluorescence in situ hybridization revealed a deletion in the 17p13.3 region, an area thought to contain tumour suppressor genes, including the hypermethylated in cancer 1 gene. Considering the rarity of gallbladder cancer in children, we propose that MDS as the genetic background of this patient may have played a role in the occurrence of gallbladder cancer.


CONCLUSIONS
Our present report indicates that the emergence of cancers should be taken into consideration during the long-term follow-up of patients with MDS.
Ueda
Shizuyo
S
Department of Paediatrics, Kobe City General Hospital, Kobe, Japan. pepper-s@cg8.so-net.ne.jp
Kubota
Masaru
M
Kuroki
Shigekazu
S
Wada
Michihiko
M
D000015:Abnormalities, Multiple / Q000235:genetics*; D000230:Adenocarcinoma / Q000209:etiology*; D000293:Adolescent; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D005706:Gallbladder Neoplasms / Q000209:etiology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D013577:Syndrome