title: Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.
abstract: A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.
authors.affiliation: Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Ravindranadh V
authors.initials: RV
authors.lastname: Somu
authors.forename: Helena
authors.initials: H
authors.lastname: Boshoff
authors.forename: Chunhua
authors.initials: C
authors.lastname: Qiao
authors.forename: Eric M
authors.initials: EM
authors.lastname: Bennett
authors.forename: Clifton E
authors.initials: CE
authors.lastname: Barry
authors.forename: Courtney C
authors.initials: CC
authors.lastname: Aldrich
mesh_terms: D000904:Antibiotics, Antitubercular / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017262:Siderophores / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013329:Structure-Activity Relationship
chemical_list: D000904:Antibiotics, Antitubercular; D009705:Nucleosides; D017262:Siderophores