Drosha versus ADAR: wrangling over pri-miRNA.
Processing of a mammalian hematopoietic microRNA precursor is suppressed when it is edited by ADARs. The edited pri-miRNA can subsequently be degraded by Tudor-SN.
O'Connell
Mary A
MA
Keegan
Liam P
LP
D000243:Adenosine Deaminase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D017393:RNA Editing / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional; D016601:RNA-Binding Proteins; D043244:Ribonuclease III / Q000378:metabolism*
D035683:MicroRNAs; D016601:RNA-Binding Proteins; D043244:Ribonuclease III; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase