[Effect of adement preparation and its low-molecular fractions on development of neurodegenerative processes in Drosophila melanogaster mutants].
Neuroprotective and neuroactivative properties of Adement preparations and the influence of Adement and its low-molecular fractions (9-10 Da, 4-6 Da, 1-2 Da) on dinamics of neurodegenerations, viability and lifetime of Drosophila melanogaster mutants with changes of brain structures have been investigated. It was shown that Adement as neuroprotector causes the delay of neurodegenerative changes by 10-15 days and increase of lifetime by 14%. None of the studied low-molecular fractions did not reveal the better effect on these indices than the total preparation. The use of Adement as neuroactivating agent in the complex with other preparations (neuroprotective agent + neuroactivating agent + neuroretardant) is more effective as the development of neurodegenerative changes in mutant brain stops for 20-27 days depending on genotype and a mean lifetime increases by 10-33%.
Radysh
V
V
Stupnyts'ka
I
I
Kucherenko
M
M
Plakhta
O
O
Makarenko
O
O
Hasul'
E
E
Maksymiv
D
D
Chernyk
Ia
Ia
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004331:Drosophila melanogaster / Q000235:genetics*; D005838:Genotype; D008136:Longevity / Q000187:drug effects; D008970:Molecular Weight; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D018696:Neuroprotective Agents; D010446:Peptide Fragments