Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis.
We examined the findings from single-fiber electromyography in extensor digitorum communis (EDC) and orbicularis oculi (OOc) in 13 myasthenia gravis (MG) patients with muscle-specific kinase antibodies (MuSK-MG) and 12 MG patients with acetylcholine receptor antibodies (AChR-MG) with similar clinical scores. More than 70% of AChR-MG patients had abnormal jitter in both EDC and OOc, but the majority of MuSK-MG patients had normal jitter in EDC despite abnormal jitter in OOc. These findings demonstrate clear differences between the neurophysiology of MuSK-MG and AChR-MG.
Farrugia
Maria Elena
ME
Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, UK.
Kennett
Robin P
RP
Newsom-Davis
John
J
Hilton-Jones
David
D
Vincent
Angela
A
D000110:Acetylcholinesterase / Q000378:metabolism; D000906:Antibodies / Q000032:analysis; D004185:Disability Evaluation; D004576:Electromyography; D004594:Electrophysiology; D005121:Extremities / Q000294:innervation; D005152:Facial Muscles / Q000294:innervation / Q000502:physiology*; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D009157:Myasthenia Gravis / Q000276:immunology / Q000378:metabolism*; D009460:Neurologic Examination; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000276:immunology / Q000378:metabolism*
D000906:Antibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases; D000110:Acetylcholinesterase