Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids.
Keeping in view the interesting chemistry and pharmacological importance of harmine series of bases -- the beta-carboline alkaloids, a number of new derivatives of tetrahydroharmine and harmalol have been prepared and characterized through spectral studies. Some of these derivatives showed spasmolytic activity. It was observed that all the N-acyl tetrahydroharmine derivatives are stable, not labile and no ring opening occurs in these compounds, as reported recently.
Begum
Sabira
S
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. sabira@khi.comsats.net.pk
Imran Hassan
Syed
S
Siddiqui
Bina S
BS
Ifzal
Rehana
R
Perwaiz
Sobiya
S
Kiran
Tahira
T
Shaheen
Farhana
F
Ghayur
M Nabeel
MN
Gilani
Anwar H
AH
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D006247:Harmine / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D010276:Parasympatholytics / Q000494:pharmacology*; D011817:Rabbits; D013057:Spectrum Analysis / Q000379:methods
D000470:Alkaloids; D010276:Parasympatholytics; D006247:Harmine