Preliminary report: Correct diagnosis of sex in fetal cells isolated from cervical mucus during early pregnancy.
The aim of this study was to determine the accuracy of sexing fetal cells isolated from cervical mucus. Immunopositive cells identified using a fetal-specific antibody were isolated and subjected to genetic analysis. Fetal sex was predicted in all 22 samples, as confirmed by analysis of the corresponding placental tissue. This study validates the accuracy of our test for sex diagnosis and confirms the ability to effectively recover and analyse fetal cells from the cervical mucus during early pregnancy.
Mantzaris
Debbie
D
Monash IVF, Clayton, Victoria, Australia. dmantzaris@monashivf.edu.au
Cram
David
D
Healy
Christine
C
Howlett
Donna
D
Kovacs
Gab
G
D000328:Adult; D002582:Cervix Mucus / Q000166:cytology*; D005260:Female; D005333:Fetus / Q000166:cytology*; D005865:Gestational Age; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D012307:Risk Factors; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012732:Sex Determination Analysis / Q000379:methods*