Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: case report and review of literature.
A 7-year-old girl presented six hours after ingestion of a yellow oleander seed (Thevetia peruviana) with severe emesis, change in colour vision and complete heart block. Initial treatment with phenytoin and isoprenalin infusion led to intermittent supraventricular and ventricular tachycardia. The patient was then treated with two intravenous doses of 190 mg of digoxin-specific Fab antibody fragments (Digibind). Subsequently the patient's rhythm reverted to sinus rhythm and the symptoms resolved within 2 hours.


CONCLUSIONS
administration of digoxin-specific Fab antibody fragments in an otherwise healthy child after oleander intoxication is safe and without adverse reactions.
Camphausen
C
C
The Prince Charles Hospital, Rode Road, Chermside 4065, Australien. christoph_camphausen@health.qld.gov.au
Haas
N A
NA
Mattke
A C
AC
D002301:Cardiac Glycosides / Q000506:poisoning*; D002648:Child; D004077:Digoxin / Q000276:immunology; D005260:Female; D006327:Heart Block / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D010939:Plant Poisoning / Q000150:complications* / Q000188:drug therapy*; D031052:Thevetia / Q000506:poisoning*; D016896:Treatment Outcome
D002301:Cardiac Glycosides; D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments; D004077:Digoxin