title: Organometallic enantiomeric scaffolding: organometallic chirons. Total synthesis of (-)-Bao Gong Teng A by a molybdenum-mediated [5 + 2] cycloaddition.
abstract: Bao Gong Teng A, an optically active tropane alkaloid with hypotensive and miotic activity isolated from the Chinese herb Erycibe obtusifolia Benth, was synthesized by an "organometallic chiron" strategy in which single enantiomers of TpMo(CO)(2)(eta(3)-pyridinyl) complexes are produced in quantity and then elaborated easily and efficiently to generate, after demetalation, highly enantiopure advanced synthetic intermediates possessing the tropane core.
authors.affiliation: Sanford S. Atwood Chemistry Center, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lanny S
authors.initials: LS
authors.lastname: Liebeskind
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D003500:Cyclization; D008982:Molybdenum / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D013237:Stereoisomerism; D014326:Tropanes / Q000138:chemical synthesis
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D009942:Organometallic Compounds; D014326:Tropanes; C027863:bao gong teng A; D008982:Molybdenum