The serotonergic system and its role in cocaine addiction.
Cocaine is an alkaloid with psychostimulant action and high addictive potential. It possesses high affinity for the transporters of dopamine, serotonin (5-HT) and noradrenaline, and blocks reuptake of the above-mentioned monoamines. The present review summarized the contribution of 5-HT neurotransmitter system to rewarding and aversive properties of cocaine, to cocaine withdrawal and its long-term abuse. The present state of knowledge of 5-HT neurotransmission justifies the opinion that pharmacological manipulation in the 5-HT system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse.
Filip
Małgorzata
M
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. filip@if-pan.krakow.pl
Frankowska
Małgorzata
M
Zaniewska
Magdalena
M
Gołda
Anna
A
Przegaliński
Edmund
E
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000009:adverse effects* / Q000378:metabolism; D003042:Cocaine / Q000009:adverse effects* / Q000378:metabolism; D019970:Cocaine-Related Disorders / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D006801:Humans; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D009435:Synaptic Transmission
D000697:Central Nervous System Stimulants; D050483:Dopamine Plasma Membrane Transport Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; D003042:Cocaine