[HMGA proteins and their genes as a potential neoplastic biomarkers].
HMGA proteins and their genes are described in this article. HMGA proteins reveal ability to bind DNA in AT-rich regions, which are characteristic for gene promoter sequences. This interaction lead to gene silencing or their overexpression. In normal tissue HMGA proteins level is low or even undetectable. During embriogenesis their level is increasing. High HMGA proteins level is characteristic for tumor phenotype of spontaneous and experimental malignant neoplasms. High HMGA proteins expression correlate with bad prognostic factors and with metastases formation. HMGA genes expression can be used as a marker of tumor progression. Present studies connected with tumor gene therapy based on HMGA proteins sythesis inhibition by the use of viral vectors containing gene encoding these proteins in antisence orientation, as well as a new potential anticancer drugs acting as crosslinkers between DNA and HMGA proteins suggest their usefulness as a targets in cancer therapy.
Balcerczak
Ewa
E
Pracownia Biologii Molekularnej, Zakład Biochemii Farmaceutycznej, Uniwersytet Medyczny, Lódź.
Balcerczak
Mariusz
M
Mirowski
Marek
M
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D020868:Gene Silencing; D024003:HMGA Proteins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
D014408:Biomarkers, Tumor; D024003:HMGA Proteins