Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1.
Andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide, ent-labdene diterpenes isolated from Andrographis paniculata showed viricidal activity against herpes simplex virus 1 (HSV-1). None of these compounds exhibited significant cytotoxicity at viricidal concentrations.
Wiart
C
C
Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia. christophe_wiart@yahoo.com
Kumar
K
K
Yusof
M Y
MY
Hamimah
H
H
Fauzi
Z M
ZM
Sulaiman
M
M
D035685:Andrographis; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D014709:Vero Cells
D000998:Antiviral Agents; D004224:Diterpenes; D005960:Glucosides; D010936:Plant Extracts; D013764:Tetrahydronaphthalenes; C030419:andrographolide; C082497:neoandrographolide