Urinary transforming growth factor-beta1 in feline chronic renal failure.
Transforming growth factor-beta1 (TGF-beta1), an inflammatory cytokine, plays a role in tissue fibrosis, such as glomerular sclerosis and tubulointerstitial fibrosis of the kidneys. In the present study, the urinary TGF-beta1 level of cats diagnosed with chronic renal failure (CRF) was measured to investigate its relationship to the pathogenesis of feline CRF. Urinary TGF-beta1 levels (TGF-beta1/creatinine ratio) were significantly increased compared with healthy controls, whereas serum levels of TGF-beta1 were not. These results indicate that TGF-beta1 is expressed in the kidneys of CRF cats, and that it was reflected in the urinary TGF-beta1 level. Therefore, TGF-beta1 may play a role in feline CRF, and urinary TGF-beta1 could be used as a clinical marker for renal fibrosis.
Arata
Sayaka
S
Depertment of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Ohmi
Aki
A
Mizukoshi
Fuminori
F
Baba
Kenji
K
Ohno
Koichi
K
Setoguchi
Asuka
A
Tsujimoto
Hajime
H
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002371:Cat Diseases / Q000503:physiopathology* / Q000652:urine*; D002415:Cats; D003401:Creatine / Q000652:urine; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000652:urine / Q000662:veterinary*; D016212:Transforming Growth Factor beta / Q000097:blood / Q000652:urine*; D053773:Transforming Growth Factor beta1
D015415:Biomarkers; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D003401:Creatine