title: ProTherm and ProNIT: thermodynamic databases for proteins and protein-nucleic acid interactions.
abstract: ProTherm and ProNIT are two thermodynamic databases that contain experimentally determined thermodynamic parameters of protein stability and protein-nucleic acid interactions, respectively. The current versions of both the databases have considerably increased the total number of entries and enhanced search interface with added new fields, improved search, display and sorting options. As on September 2005, ProTherm release 5.0 contains 17,113 entries from 771 proteins, retrieved from 1497 scientific articles (approximately 20% increase in data from the previous version). ProNIT release 2.0 contains 4900 entries from 273 research articles, representing 158 proteins. Both databases can be queried using WWW interfaces. Both quick search and advanced search are provided on this web page to facilitate easy retrieval and display of the data from these databases. ProTherm is freely available online at http://gibk26.bse.kyutech.ac.jp/jouhou/Protherm/protherm.html and ProNIT at http://gibk26.bse.kyutech.ac.jp/jouhou/pronit/pronit.html.
authors.affiliation: Department of Bioscience and Bioinformatics, Kyushu Institute of Technology (KIT), 680-4 Kawazu Iizuka, 820-8502 Japan.
authors.forename: M D Shaji
authors.initials: MD
authors.lastname: Kumar
authors.forename: K Abdulla
authors.initials: KA
authors.lastname: Bava
authors.forename: M Michael
authors.initials: MM
authors.lastname: Gromiha
authors.forename: Ponraj
authors.initials: P
authors.lastname: Prabakaran
authors.forename: Koji
authors.initials: K
authors.lastname: Kitajima
authors.forename: Hatsuho
authors.initials: H
authors.lastname: Uedaira
authors.forename: Akinori
authors.initials: A
authors.lastname: Sarai
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry; D030541:Databases, Genetic; D020407:Internet; D009154:Mutation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry; D013816:Thermodynamics; D014584:User-Computer Interface
chemical_list: D004268:DNA-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA