Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease.
Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively.
Sun
Quan-Zhong
QZ
Department of Pharmacognosy, School of Pharmacy, Fudan University.
Chen
Dao-Feng
DF
Ding
Pei-Lan
PL
Ma
Chao-Mei
CM
Kakuda
Hiroko
H
Nakamura
Norio
N
Hattori
Masao
M
D002855:Chromatography, Thin Layer; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
D017320:HIV Protease Inhibitors; D017705:Lignans; C508620:longipedunin A; C508621:longipedunin B; C508622:longipedunin C