Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum.
A crystal structure is reported of the peptide Ac-Ala-Asn-Pro-Asn-Ala-NH2, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I beta-turn, which is stabilized by hydrogen bonding between the CO of Asn2 and the NH of Ala5 as well as between the O(delta) of Asn2 and the NH of Asn4.
Ghasparian
Arin
A
Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Moehle
Kerstin
K
Linden
Anthony
A
Robinson
John A
JA
D020816:Amino Acid Motifs; D000818:Animals; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000737:chemistry*; D015800:Protozoan Proteins / Q000737:chemistry*; D013237:Stereoisomerism
D009842:Oligopeptides; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan