Living donor lobar lung transplantation: current status and future directions.
Living lobar lung transplantation was developed as a procedure for adult and pediatric patients considered too ill to await cadaveric transplantation. One hundred thirty-eight living lobar transplants have been performed in 133 patients at our institution between January 1993 and September 2004. Actuarial 1-, 3-, and 5-year survival are similar to ISHLT registry data. There has been no donor mortality, and morbidity has been relatively low. Long-term postoperative pulmonary function studies demonstrate the relatively smaller-sized lobes can provide similar pulmonary function and exercise capacity to bilateral cadaveric lung transplants. Living lobar lung transplantation should be considered a viable option in patients with end-stage lung disease deemed unable to await a cadaveric organ and in those patients in which further deterioration would make cadaveric transplantation inappropriate.
Barr
M L
ML
Department of Cardiothoracic Surgery, University of Southern California, Los Angeles, 90033, USA. mbarr@surgery.usc.edu
Schenkel
F A
FA
Bowdish
M E
ME
Starnes
V A
VA
D000328:Adult; D002102:Cadaver; D002648:Child; D006801:Humans; D019520:Living Donors; D008168:Lung; D016040:Lung Transplantation / Q000401:mortality / Q000502:physiology / Q000639:trends*; D012129:Respiratory Function Tests; D016019:Survival Analysis; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome; D014850:Waiting Lists