Hereditary periodic fever syndrome sans fever or distinct periodicity presenting with psychosis.
The genetic basis for several hereditary periodic fever syndromes has been identified and consequently, the phenotypic spectrum of these disorders has broadened. We describe a young woman with tumor necrosis factor receptor-associated periodic syndrome (TRAPS), proven by mutational analysis, who presented with psychosis but without fever, symptom periodicity, or similar family medical history. This patient represents the first case of TRAPS-associated psychosis. This case illustrates the importance of mutation analysis for this group of disorders in individuals presenting with unexplained inflammatory symptoms and recurrent psychoses.
Hurst
Miriam
M
Department of Clinical Immunology, Auckland Hospital, New Zealand.
Hull
Keith
K
Nicholls
Dave
D
Ameratunga
Rohan
R
D000293:Adolescent; D004247:DNA / Q000032:analysis; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D000068800:Etanercept; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D010507:Periodicity; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D012008:Recurrence
D007074:Immunoglobulin G; D007155:Immunologic Factors; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D011993:Recombinant Fusion Proteins; D004247:DNA; D000068800:Etanercept