title: [A case-control study on the mxA polymorphisms and susceptibility to severe acute respiratory syndromes].
abstract: OBJECTIVE
  To investigate the association between the genetic polymorphisms of myxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes (SARS).
  
  
  METHODS
  A case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the T/G polymorphism at position-88 in the mxA gene promoter. Information on related factors of SARS was collected using a pre-testing questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.
  
  
  RESULTS
  Sixty-six cases and sixty-four controls were selected for the study. Comparing with GG genotype, the proportion of GT genotype were significantly higher in the case group (81.3%) than that in the control group (62.5%)) with an OR (95% CI) of 2.700 (1.208-6.037). Multivariate logistic regression analysis revealed that the significant association remained after factors as wearing masks, protection gowns and eye-protection when contacting with SARS patient etc. were adjusted with an OR (95 % CI) of 2.911 (1.027-8.250).
  
  
  CONCLUSIONS
  mxA promoter-88G/T SNP might be confered to host genetic susceptibility to SARS in Chinese Han population.
authors.affiliation: Epidemiological Department of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: Pan-he
authors.initials: PH
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Tang
authors.forename: Tian-bao
authors.initials: TB
authors.lastname: Wang
authors.forename: Yi-he
authors.initials: YH
authors.lastname: Luan
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.forename: Zhao-yang
authors.initials: ZY
authors.lastname: Cao
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Wu
authors.forename: Qiu-min
authors.initials: QM
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Wu-chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D064547:Myxovirus Resistance Proteins; D011110:Polymorphism, Genetic; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics*
chemical_list: C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins