title: Split for two adults: what is the real feasibility?
abstract: BACKGROUND
  A split liver for two adults is a good theoretical option but the number of cases is low. We have tried to assess the feasibility of this technique.
  
  
  METHODS
  From April 2002 to April 2004, we evaluated 81 donors of which only 59 (72.8%) were used for transplantation of which 10 were grafted in other centers (pediatric or emergency code). Among the 49 donors the criteria for splitting were: ages >14 and <50 years, weight >70 and <100 kg, less than 3 days in the intensive care unit (ICU), hemodynamic stability, Na(+) < 160 mg/L, liver enzymes elevated no more than twofold, no macroscopic steatosis, and procurement in our hospital.
  
  
  RESULTS
  The mean donor age was 50.7 years (range: 16 to 77) of whom 25 were men (51%). The mean weight was 65.7 kg (range: 50 to 100) and days of ICU stay, 3 (range: 1 to 23). Six grafts (12%) were split. The reasons for not splitting were: age (n = 26 [53%]), weight (n = 17 [34.7%]), UCI >3 days (n = 9 [18.3%]), Na(+) > 160 (n = 1 [2%]), blood liver test elevated (n = 5 [10.2%]), steatosis (n = 6 [12.2%]), and procurement outside our center (n = 20 [40.8%]). The donors not suitable for splitting had: only one criteria (n = 12 [24.4%]; 2 (n = 23 [46.9%], 3 (n = 6 [12.2%]) or 4 (n = 2 [4.1%]). If we had had two suitable recipients, we could performed six more liver transplantations (12.2% increase).
  
  
  CONCLUSIONS
  The theoretical feasibility of a split liver for two adults is 12.2%, but the actual probability is lower because of lack of two adequate candidates.
authors.affiliation: Unidad de Trasplante Hepático, Hospital Virgen de las Nieves, Granada, Spain. jose_ramia@hotmail.com
authors.forename: J M
authors.initials: JM
authors.lastname: Ramia
authors.forename: A
authors.initials: A
authors.lastname: Mansilla
authors.forename: J
authors.initials: J
authors.lastname: Villar
authors.forename: M A
authors.initials: MA
authors.lastname: Cabrera
authors.forename: D
authors.initials: D
authors.lastname: Garrote
authors.forename: J A
authors.initials: JA
authors.lastname: Ferron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D016031:Liver Transplantation; D008875:Middle Aged; D018579:Patient Selection; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods*