title: Rifampin augments cytokine-induced nitric oxide production in human alveolar epithelial cells.
abstract: Rifampin increased nitric oxide production and inducible nitric oxide synthase expression in alveolar cells stimulated with cytokines. Nitric oxide concentrations after induction with cytokines, cytokines with 10 microg/ml rifampin, and cytokines with 50 microg/ml rifampin were 3.2, 4.5, and 8.8 microM, respectively (P < 0.02 versus cytokines alone). This indicates that rifampin modulates the immune response.
authors.affiliation: Laboratory of Infectious Diseases, Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva 49100, Israel. yuhas@post.tau.ac.il
authors.forename: Yael
authors.initials: Y
authors.lastname: Yuhas
authors.forename: Eva
authors.initials: E
authors.lastname: Berent
authors.forename: Hila
authors.initials: H
authors.lastname: Ovadiah
authors.forename: Inbar
authors.initials: I
authors.lastname: Azoulay
authors.forename: Shai
authors.initials: S
authors.lastname: Ashkenazi
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D004790:Enzyme Induction; D004847:Epithelial Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000166:cytology; D012293:Rifampin / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D012293:Rifampin