title: EPD in its twentieth year: towards complete promoter coverage of selected model organisms.
abstract: The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collection of eukaryotic POL II promoters, experimentally defined by a transcription start site (TSS). Access to promoter sequences is provided by pointers to positions in the corresponding genomes. Promoter evidence comes from conventional TSS mapping experiments for individual genes, or, starting from release 73, from mass genome annotation projects. Subsets of promoter sequences with customized 5' and 3' extensions can be downloaded from the EPD website. The focus of current development efforts is to reach complete promoter coverage for important model organisms as soon as possible. To speed up this process, a new class of preliminary promoter entries has been introduced as of release 83, which requires less stringent admission criteria. As part of a continuous integration process, new web-based interfaces have been developed, which allow joint analysis of promoter sequences with other bioinformatics resources developed by our group, in particular programs offered by the Signal Search Analysis Server, and gene expression data stored in the CleanEx database. EPD can be accessed at http://www.epd.isb-sib.ch.
authors.affiliation: Swiss Institute of Bioinformatics, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
authors.forename: Christoph D
authors.initials: CD
authors.lastname: Schmid
authors.forename: Rouaïda
authors.initials: R
authors.lastname: Perier
authors.forename: Viviane
authors.initials: V
authors.lastname: Praz
authors.forename: Philipp
authors.initials: P
authors.lastname: Bucher
mesh_terms: D000818:Animals; D003196:Computer Graphics; D030561:Databases, Nucleic Acid / Q000266:history; D004331:Drosophila melanogaster / Q000235:genetics; D023281:Genomics; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D020407:Internet; D012275:Oryza / Q000235:genetics; D011401:Promoter Regions, Genetic; D014584:User-Computer Interface