title: Antimicrobial beta-peptoids by a block synthesis approach.
abstract: Antimicrobial peptides and their mimetics offer a potential new disinfective tool. beta-Peptoids (oligo-N-substituted beta-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-beta-peptoids were first prepared and then ligated via amide bond formation to synthesize larger beta-peptoids was developed. The beta-peptoids were found to possess moderate activity in an Escheridchia coli assay.
authors.affiliation: DuPont Central Research and Development, PO Box 80328, Experimental Station, Wilmington, DE 19880-0328, USA. Steven.W.Shuey@usa.dupont.com
authors.forename: Steven W
authors.initials: SW
authors.lastname: Shuey
authors.forename: William J
authors.initials: WJ
authors.lastname: Delaney
authors.forename: Mukesh C
authors.initials: MC
authors.lastname: Shah
authors.forename: Mark A
authors.initials: MA
authors.lastname: Scialdone
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D034444:Peptoids