Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei.
A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.
Guo
Yuanqiang
Y
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Xu
Jing
J
Li
Yushan
Y
Watanabe
Ryuichi
R
Oshima
Yasukatsu
Y
Yamakuni
Tohru
T
Ohizumi
Yasushi
Y
D000818:Animals; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009414:Nerve Growth Factors / Q000737:chemistry*; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014632:Valerian / Q000737:chemistry*
D039823:Iridoids; D009414:Nerve Growth Factors; D012717:Sesquiterpenes