Detection of BK virus and adenovirus in the urine from children after allogeneic stem cell transplantation.
The development of hemorrhagic cystitis (HC) and urinary excretion of polyoma BK virus (BKV) and adenovirus (ADV) was investigated by polymerase chain reaction in 20 children undergoing allogeneic stem cell transplantation. Five children developed HC, and all of them excreted BKV; however, only 1 excreted ADV, suggesting that BKV is more significant cause of HC than ADV in children undergoing stem cell transplantation.
Hatakeyama
Naoki
N
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan. nhatake@sapmed.ac.jp
Suzuki
Nobuhiro
N
Yamamoto
Masaki
M
Kuroiwa
Yuki
Y
Hori
Tsukasa
T
Mizue
Nobuo
N
Tsutsumi
Hiroyuki
H
D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification*; D000257:Adenoviridae Infections / Q000175:diagnosis* / Q000821:virology; D000293:Adolescent; D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000821:virology*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000175:diagnosis* / Q000821:virology; D014184:Transplantation, Homologous / Q000009:adverse effects; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000821:virology; D014556:Urine / Q000821:virology