title: Adoptive transfer of allogeneic antigen-specific T cells.
abstract: Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. sriddell@fhcrc.org
authors.forename: Stanley R
authors.initials: SR
authors.lastname: Riddell
authors.forename: Marie
authors.initials: M
authors.lastname: Bleakley
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nishida
authors.forename: Carolina
authors.initials: C
authors.lastname: Berger
authors.forename: Edus H
authors.initials: EH
authors.lastname: Warren
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D020544:Graft vs Leukemia Effect / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D015778:Minor Histocompatibility Antigens / Q000276:immunology*
chemical_list: D007519:Isoantigens; D015778:Minor Histocompatibility Antigens