title: [Treatment resistant schizophrenia, residual subtype: symptom improvement after additional treatment with amisulpride].
abstract: BACKGROUND
  Therapy resistant, severe residual schizophrenia poses major challenges for the psychiatric pharmacological treatment.
  
  
  METHODS
  We report about a 44-year old schizophrenic male who has been detained in a closed forensic ward for 10 years, following a conviction in one manslaughter case. Despite various pharmacological treatment efforts severe residual schizophrenia remained.
  
  
  RESULTS
  Adding Amisulpride to the ongoing treatment with Olanzapine achieved a noticeable improvement of symptoms, resulting in the possibility of relaxing imprisonment conditions.
  
  
  CONCLUSIONS
  A combination of Amisulpride and Olanzapine seems to be effective in treating severe residual schizophrenia.
authors.affiliation: Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Psychiatrie und Psychotherapie. k.wolf@uke.uni-hamburg.de
authors.forename: Karsten
authors.initials: K
authors.lastname: Wolf
authors.forename: Stefan
authors.initials: S
authors.lastname: Veismann
authors.forename: Guntram
authors.initials: G
authors.lastname: Knecht
authors.forename: Dieter
authors.initials: D
authors.lastname: Naber
mesh_terms: D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects; D003134:Commitment of Persons with Psychiatric Disorders / Q000331:legislation & jurisprudence; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006708:Homicide / Q000331:legislation & jurisprudence* / Q000523:psychology; D006801:Humans; D007298:Insanity Defense; D008297:Male; D000077152:Olanzapine; D011329:Prisoners / Q000523:psychology*; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D013469:Sulpiride / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D013469:Sulpiride; D000077582:Amisulpride; D003024:Clozapine; D006220:Haloperidol; D000077152:Olanzapine