Fourth-generation fluoroquinolones in the treatment of mycobacterial infectious keratitis after laser-assisted in situ keratomileusis surgery.
METHODS
Infectious keratitis after laser-assisted in situ keratomileusis (LASIK) is a rare complication that may be challenging to diagnose and treat. We discuss some of the reasons for difficulties diagnosing postoperative atypical or nontuberculous mycobacterial infection and establishing an effective treatment, with reference to reports of comparative antibacterial activity of the most commonly used antibiotics.


CONCLUSIONS
To the best of our knowledge, we are the first to report the use of the fourth-generation fluoroquinolone moxifloxacin in combination therapy for the successful treatment of this condition.
Lee
Sao Bing
SB
Department of Ophthalmology and Vision Science, University of Toronto, Ontario.
Oliver
Karine M
KM
Strube
Yi Ning J
YN
Mohan
Subhash K
SK
Slomovic
Allan R
AR
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001372:Aza Compounds / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D000077266:Moxifloxacin; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects / Q000302:isolation & purification; D011183:Postoperative Complications; D011804:Quinolines / Q000627:therapeutic use*; D013524:Surgical Flaps; D014031:Tobramycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D017291:Clarithromycin; D000077266:Moxifloxacin; D014031:Tobramycin