Antioxidative flavanone glycosides from the branches and leaves of Viscum coloratum.
Two new flavanone glucosides, (2S)-homoeriodictyol 7,4'-di-O-beta-D-glucopyranoside (4) and (2R)-eriodictyol 7,4'-di-O-beta-D-glucopyranoside (5) were isolated from the branches and leaves of Viscum coloratum (KOMAR) NAKAI (Loranthaceae), along with three known flavanone glucosides: (2S)-homoeriodictyol 7-O-beta-D-glucopyranoside (1), (2S)-eriodictyol 7-O-beta-D-glucopyranoside (2), and (2S)-naringenin 7-O-beta-D-glucopyranoside (3). The structures of these compounds were elucidated using spectroscopic methods. The antioxidant activities of these isolated compounds were evaluated by colorimetric methods based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. All the compounds showed potent albeit varied degrees of antioxidative activities and the structure-activity relationship is discussed.
Yao
Hui
H
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, PR China.
Liao
Zhi-Xin
ZX
Wu
Qiong
Q
Lei
Guang-Qing
GQ
Liu
Zhi-Jun
ZJ
Chen
Dao-Feng
DF
Chen
Jia-Kuan
JK
Zhou
Tong-Shui
TS
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D017665:Hydroxyl Radical / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D016877:Oxidants / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry; D028181:Viscum / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000737:chemistry
C508625:(2R)-eriodictyol 7,4'-di-O-beta-D-glucopyranoside; C508624:(2S)-homoeriodictyol 7,4'-di-O-beta-D-glucopyranoside; D000975:Antioxidants; D044950:Flavanones; D016166:Free Radical Scavengers; D005960:Glucosides; D016877:Oxidants; D010936:Plant Extracts; D013481:Superoxides; D017665:Hydroxyl Radical; D014969:Xanthine Oxidase