title: Subcutaneous sarcoidosis: is it a specific subset of cutaneous sarcoidosis frequently associated with systemic disease?
abstract: BACKGROUND
  Skin is involved in 25% of cases of sarcoidosis. The lesions are specific and nonspecific depending on the presence or absence of granulomas, respectively. Specific lesions are not thought to have prognostic significance and are not associated with systemic disease.
  
  
  OBJECTIVE
  We sought to evaluate for the presence or absence of systemic disease in patients with subcutaneous sarcoidosis.
  
  
  METHODS
  With diagnostic criteria of subcutaneous sarcoidosis, 33 cases were identified in the literature and 21 cases in our institutional database. A retrospective clinical and pathologic review of these cases was conducted.
  
  
  RESULTS
  Subcutaneous sarcoidosis is characterized by a peak incidence during the fourth decade; female predisposition; asymptomatic to slightly tender lesions typically involving the upper extremities; cutaneous lesional clustering and multiplicity; autoimmune disease associations at time of diagnosis in a subset of cases; systemic disease associations at diagnosis in most patients, typically consisting of bilateral hilar adenopathy; and a favorable response to oral corticosteroid therapy.
  
  
  CONCLUSIONS
  Retrospective analysis with inadequate documentation of therapeutic regimens and their responses in some cases is a limitation of this study.
  
  
  CONCLUSIONS
  The confirmatory diagnosis of subcutaneous sarcoidosis depends on identifying pannicular noninfectious sarcoidal or epithelioid granulomas with minimal lymphocytic inflammation. Subcutaneous sarcoidosis is the only specific subset of cutaneous sarcoidosis frequently associated with systemic disease.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Iftikhar
authors.initials: I
authors.lastname: Ahmed
authors.forename: Sujata R
authors.initials: SR
authors.lastname: Harshad
mesh_terms: D006801:Humans; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000145:classification* / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D012871:Skin Diseases / Q000145:classification* / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D040521:Subcutaneous Tissue