title: Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery.
abstract: OBJECTIVE
  We investigated changes in serum uric acid across pregnancy in women with gestational hyperuricemia at delivery, with and without preeclampsia, compared with normal pregnant and women with preeclampsia without gestational hyperuricemia.
  
  
  METHODS
  This was a nested case-control study of 116 controls, 27 women with preeclampsia with predelivery hyperuricemia, 37 women with preeclampsia without predelivery hyperuricemia, and 35 women with gestational hypertension with hyperuricemia at delivery but without proteinuria. Serum uric acid and creatinine was measured across pregnancy.
  
  
  RESULTS
  Women with predelivery hyperuricemia, with and without preeclampsia, had increased uric acid concentrations across pregnancy compared with controls, after 25 weeks' gestation compared with women with preeclampsia without predelivery hyperuricemia. Adjusting for differences in glomerular filtration by serum creatinine accounted for part but not all of the increase in serum uric acid among women with preeclampsia and predelivery hyperuricemia.
  
  
  CONCLUSIONS
  Among women with hyperuricemia at delivery, elevations in uric acid occur early. Multiple mechanisms may contribute to increased uric acid including changes in renal function.
authors.affiliation: Magee-Womens Research Institute, Pittsburgh, PA 15213, USA. rsirwp@mwri.magee.edu
authors.forename: Robert W
authors.initials: RW
authors.lastname: Powers
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Bodnar
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Ness
authors.forename: Katheryn M
authors.initials: KM
authors.lastname: Cooper
authors.forename: Marcia J
authors.initials: MJ
authors.lastname: Gallaher
authors.forename: Michael P
authors.initials: MP
authors.lastname: Frank
authors.forename: Ashi R
authors.initials: AR
authors.lastname: Daftary
authors.forename: James M
authors.initials: JM
authors.lastname: Roberts
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D036861:Delivery, Obstetric; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000503:physiopathology; D009994:Osmolar Concentration; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000097:blood* / Q000503:physiopathology; D011261:Pregnancy Trimester, First; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D003404:Creatinine