Cross-metathesis: efficient preparation of trialkyl-substituted isoprenoid olefins as key-intermediates for tocopherol synthesis.
A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.
Netscher
Thomas
T
Research and Development, DSM Nutritional Products, P.O. Box 3255, CH-4002 Basel, Switzerland. thomas.netscher@dsm.com
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism; D024505:Tocopherols / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D009942:Organometallic Compounds; D012428:Ruthenium; D024505:Tocopherols