title: [Molecular targets for the treatment of bone metastases].
abstract: Bone is one of the most common sites of cancer metastases. Bone metastases cause devastating complications including intractable bone pain, pathologic fractures and hypercalcemia, and profoundly harm the quality of life of the patients. Therefore, intervention of bone metastases is critical for the management of cancer patients and improvement of their outcome. Nevertheless, cancer cells colonizing in bone are essentially uncontrollable with currently available therapies. In this review, the molecular targets for the treatment of bone metastases are discussed.
authors.affiliation: Department of Biochemistry, Osaka University Graduate School of Dentistry.
authors.forename: Toru
authors.initials: T
authors.lastname: Hiraga
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary*; D001842:Bone and Bones / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D015232:Dinoprostone / Q000096:biosynthesis; D006801:Humans
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D051546:Cyclooxygenase 2; D015232:Dinoprostone