title: Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias : report of six cases and review of literature.
abstract: We report 5 cases of chronic myelogenous leukemia (CML) and 1 case of acute myeloid leukemia (AML) with the dual presence of t(9;22) and inv(16). The 6 patients were 5 men and 1 woman with a median age of 42.5 years. All cases were BCR-ABL+ with p210 products detected in all CML cases and a p190 product detected in the AML case. An increase in bone marrow eosinophils was detected in 3 of 5 cases, and abnormal eosinophils were identified in these 3 cases. The CBFbeta-MYH11 fusion gene was confirmed in all 3 CML cases and the 1 AML case tested, and this correlated with the presence of abnormal eosinophils with coarse basophilic granules. Of 5 patients with CML, 4 had a rapid transformation to myeloid accelerated phase of blast crisis. The coexistence of t(9;22) and inv(16) in CML seems to correlate with more rapid transformation.
authors.affiliation: Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Wu
authors.forename: Marilyn L
authors.initials: ML
authors.lastname: Slovak
authors.forename: David S
authors.initials: DS
authors.lastname: Snyder
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Arber
mesh_terms: D000328:Adult; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D050658:Core Binding Factor beta Subunit / Q000235:genetics; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018995:Myosin Heavy Chains / Q000235:genetics; D010677:Philadelphia Chromosome; D011993:Recombinant Fusion Proteins / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C493692:CBFB protein, human; D050658:Core Binding Factor beta Subunit; D011993:Recombinant Fusion Proteins; D018995:Myosin Heavy Chains