Stilbenoids of Kobresia nepalensis (Cyperaceae) exhibiting DNA topoisomerase II inhibition.
Resveratrol oligomers, nepalensinol A, B and C, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were established on the basis of chemical properties and spectroscopic evidence including 2D NMR spectroscopic analysis. Nepalensinol A, B and C showed a potent inhibitory effect on topoisomerase II -- stronger than etoposide (VP-16), a topoisomerase II inhibitor used as an anti-cancer drug. Nepalensinol B, in particular, exhibited the most potent activity with an IC(50) of 0.02 microg/ml.
Yamada
Masashi
M
Meiji Dairies Corporation, 2-10, Shinsuna 1-chome, Koto-Ku Tokyo 136-8908, Japan.
Hayashi
Ken-Ichiro
K
Hayashi
Hiroshi
H
Ikeda
Shogo
S
Hoshino
Takuji
T
Tsutsui
Ken
K
Tsutsui
Kimiko
K
Iinuma
Munekazu
M
Nozaki
Hiroshi
H
D000818:Animals; D016831:Crithidia fasciculata / Q000235:genetics; D029785:Cyperaceae / Q000737:chemistry* / Q000378:metabolism; D018105:DNA, Kinetoplast / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
D018105:DNA, Kinetoplast; D004791:Enzyme Inhibitors; D013267:Stilbenes; D059005:Topoisomerase II Inhibitors