title: IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia.
abstract: To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan. matsumok@mui.biglobe.ne.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yasugi
authors.forename: Akinori
authors.initials: A
authors.lastname: Oki
authors.forename: Takuma
authors.initials: T
authors.lastname: Fujii
authors.forename: Chisato
authors.initials: C
authors.lastname: Nagata
authors.forename: Souei
authors.initials: S
authors.lastname: Sekiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hoshiai
authors.forename: Yuji
authors.initials: Y
authors.lastname: Taketani
authors.forename: Tadahito
authors.initials: T
authors.lastname: Kanda
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawana
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002213:Capsid / Q000276:immunology*; D036022:Capsid Proteins / Q000276:immunology*; D016022:Case-Control Studies; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D009365:Neoplasm Regression, Spontaneous; D009856:Oncogene Proteins, Viral / Q000276:immunology; D027383:Papillomaviridae / Q000145:classification / Q000276:immunology; D030361:Papillomavirus Infections / Q000276:immunology* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000821:virology; D014764:Viral Proteins; D002578:Uterine Cervical Dysplasia / Q000276:immunology* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins; D004279:DNA, Viral; D007074:Immunoglobulin G; D009856:Oncogene Proteins, Viral; D014764:Viral Proteins; C091560:L1 protein, Human papillomavirus type 6; C063317:L1 protein, Human papillomavirus type 16