Comparative study of the enantioselective separation of several antiulcer drugs by high-performance liquid chromatography and supercritical fluid chromatography.
A comparative study of the enantiomeric separation of several antiulcer drugs such as omeprazole, lansoprazole, rabeprazole and pantoprazole using HPLC and supercritical fluid chromatography (SFC) on the Chrialpak AD column is presented in this work. The results show that employing the above mentioned column only two compounds (omeprazole and pantoprazole) could be enantiomerically resolved using HPLC, on the contrary SFC allowed the enantiomeric separation of all the compounds studied with higher resolutions and lower analysis times.
Toribio
L
L
Department of Analytical Chemistry, Faculty of Science, University of Valladolid, Prado de la Magdalena s/n, 47005 Valladolid, Spain. Itoribio@qa.uva.es
del Nozal
M J
MJ
Bernal
J L
JL
Alonso
C
C
Jiménez
J J
JJ
D019840:2-Propanol; D000897:Anti-Ulcer Agents / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D000432:Methanol; D013237:Stereoisomerism
D000897:Anti-Ulcer Agents; D019840:2-Propanol; D000432:Methanol