title: Mass-dependent decline of skeletal muscle function in cancer cachexia.
abstract: CD2F1 mice were inoculated with C26 adenocarcinoma cells, followed by assessment of ex vivo muscular function. Muscles from tumor-bearing mice had a significantly lower force output during a single maximal contraction and during repeated contractions than control muscles. The relative force output, however, did not differ when corrected for muscle mass. Thus, cachexia significantly reduces absolute skeletal muscle function, but muscle "quality" appears unaltered.
authors.affiliation: Numico Research, Department of BioMedical Research, Bosrandweg 20, 6704 PH Wageningen, The Netherlands. Marchel.Gorselik@Numeco-research
authors.forename: Marchel
authors.initials: M
authors.lastname: Gorselink
authors.forename: Stefan F C
authors.initials: SF
authors.lastname: Vaessen
authors.forename: Laurens G
authors.initials: LG
authors.lastname: van der Flier
authors.forename: Inge
authors.initials: I
authors.lastname: Leenders
authors.forename: Diane
authors.initials: D
authors.lastname: Kegler
authors.forename: Eric
authors.initials: E
authors.lastname: Caldenhoven
authors.forename: Eline
authors.initials: E
authors.lastname: van der Beek
authors.forename: Ardy
authors.initials: A
authors.lastname: van Helvoort
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000704:Analysis of Variance; D000818:Animals; D002100:Cachexia / Q000209:etiology*; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology* / Q000528:radiation effects; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009374:Neoplasms, Experimental; D013997:Time Factors