title: Randomized, double-blind comparison of growth in infants receiving goat milk formula versus cow milk infant formula.
abstract: OBJECTIVE
  To compare growth of infants fed goat milk infant formula (GMF) or cow milk infant formula (CMF) and to compare tolerability and safety of the two formulas.
  
  
  METHODS
  The study was conducted in Auckland, New Zealand. This was a double-blind randomized controlled trial. Newborn term infants were randomized within 72 h of birth to GMF or CMF. Milk formula powder in single serve sachets were reconstituted and fed to infants from trial commencement until age 168 days. No other formula given from randomization until age 168 days. Infant weight, length and head circumference were measured at birth and age 14, 28, 56, 84, 112, 140 and 168 days. Bowel motion frequency and consistency, sleeping and crying patterns and adverse events were also measured.
  
  
  RESULTS
  Seventy-two infants were randomized, 36 each to GMF or CMF, with 62 infants completing the intervention. At enrollment the average weight of infants in the GMF group (mean +/- SD) was 3.33 +/- 0.43 kg and in the CMF group 3.43 +/- 0.47 kg; and at study completion 8.07 +/- 0.90 kg (GMF) and 7.87 +/- 0.99 kg (CMF). The difference in average weight gain over the study period for the GMF group versus the CMF group was not significant (+309 g; 95% CI = -49 to +668, P = 0.09). Median daily bowel motion frequency was greater in the GMF group than the CMF group (2.4 vs 1.7, P = 0.01). There were no group differences in bowel motion consistency, duration of crying, ease of settling, or frequency of adverse events.
  
  
  CONCLUSIONS
  Growth of infants fed GMF is not different to that of infants-fed CMF.
authors.affiliation: Department of Paediatrics, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand. cc.grant@auckland.ac.nz
authors.forename: C
authors.initials: C
authors.lastname: Grant
authors.forename: B
authors.initials: B
authors.lastname: Rotherham
authors.forename: S
authors.initials: S
authors.lastname: Sharpe
authors.forename: R
authors.initials: R
authors.lastname: Scragg
authors.forename: J
authors.initials: J
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Andrews
authors.forename: C
authors.initials: C
authors.lastname: Wall
authors.forename: J
authors.initials: J
authors.lastname: Murphy
authors.forename: D
authors.initials: D
authors.lastname: Lowry
mesh_terms: D000818:Animals; D001903:Bottle Feeding; D002417:Cattle; D004311:Double-Blind Method; D006041:Goats; D048788:Growth and Development / Q000502:physiology*; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D008892:Milk; D009520:New Zealand; D011446:Prospective Studies