Current and future status of prostate cancer chemoprevention.
Prostate cancer remains one of the most common malignancies in Western countries and is also increasing in Asian countries. The high incidence, influence of environmental factors, such as androgen, and extended natural history of prostate cancer provide multiple opportunities for prevention; therefore prostate cancer is an ideal candidate for chemoprevention. The development of chemoprevention strategies against prostate cancer would have a huge impact, both medically and economically. Large-scale clinical trials suggest that some agents can prevent the development of prostate cancer. Active research into chemoprevention is ongoing and gathered evidence will provide effective and safe strategies to prevent prostate cancer. This review will highlight the present status of prostate cancer chemoprevention and other mechanisms of prevention, as well as discussing the issues to be addressed.
Fujimoto
Naohiro
N
Department of Urology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka Yahatanishi Kitakyushu, 807-8555, Japan. n-fuji@med.uoeh-u.ac.jp
Nomura
Masayoshi
M
Matsumoto
Tetsuro
T
D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000502:physiology; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D015398:Signal Transduction
D000975:Antioxidants; D016718:Arachidonic Acid