title: Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis.
abstract: We investigated the effects of clenbuterol, a beta2-adrenoceptor agonist with known anabolic and neuroprotective properties, on G93A-SOD1 mice, a transgenic murine model of familial amyotrophic lateral sclerosis (ALS). Relative to saline-treated vehicle controls (0.2 ml/kg/day; i.p.), early pathologic G93A-SOD1 mice treated with clenbuterol (1.5 mg/kg/day; i.p.) demonstrated a delayed onset of hindlimb signs as measured by rotarod performance, slowed disease progression, as well as trends toward mitigated losses of lumbar motoneurons and body weight. Responses in female G93A-SOD1 mice were favorable to those of males, suggesting synergistic effects between clenbuterol and sex-specific factors. Overall, our data suggest that clenbuterol offers therapeutic effects on ALS-related neuromuscular degeneration.
authors.affiliation: Department of Neurosurgery, Harvard Medical School/Children's Hospital Boston, MA, USA. yang_teng@hms.harvard.edu
authors.forename: Yang D
authors.initials: YD
authors.lastname: Teng
authors.forename: Howard
authors.initials: H
authors.lastname: Choi
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Huang
authors.forename: Renna C
authors.initials: RC
authors.lastname: Onario
authors.forename: Walter R
authors.initials: WR
authors.lastname: Frontera
authors.forename: Evan Y
authors.initials: EY
authors.lastname: Snyder
authors.forename: Sunil
authors.initials: S
authors.lastname: Sabharwal
mesh_terms: D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000367:Age Factors; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002976:Clenbuterol / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects*; D011897:Random Allocation; D045442:Rotarod Performance Test / Q000379:methods; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000235:genetics
chemical_list: D000318:Adrenergic beta-Agonists; C109415:SOD1 G93A protein; D013482:Superoxide Dismutase; D002976:Clenbuterol