title: Sesquiterpenoids and norsesquiterpenoids from the Formosan soft coral Lemnalia laevis.
abstract: Eight new nornardosinane sequiterpenoids, laevinols A-H (1-8), a new neolemnane sesquiterpenoid, laevinone A (9), and the previously known 6beta-acetyl-4beta,5beta-dimethyl-1(10)alpha-epoxy-2beta-hydroxy-7-oxodecalin (10) and 11,12-dihydroxy-6,10-eremophiladiene (11) were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia laevis. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
authors.forename: Ali A H
authors.initials: AA
authors.lastname: El-Gamal
authors.forename: E-Ping
authors.initials: EP
authors.lastname: Chiu
authors.forename: Chia-Hua
authors.initials: CH
authors.lastname: Li
authors.forename: Shi-Yie
authors.initials: SY
authors.lastname: Cheng
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C506978:laevinone A