Trypanosoma cruzi trans-sialidase inhibits human lymphocyte proliferation by nonapoptotic mechanisms: implications in pathogenesis and transplant immunology.
Chiefly an intracellular parasite, Trypanosoma cruzi has a transient blood-borne stage (trypomastigote), the acute phase of Chagas' disease, during which surface trans-sialidase is expressed and shed by the parasite. It's immunosuppressive through the induction of apoptosis. Herein, we investigated the role of trans-sialidase as an immune modulator of allo- and xenoreactions. Trans-sialidase strongly inhibited human lymphocyte proliferation; a role for the interleukin-2 receptor CD25 was suggested by flow cytometry. These results may have implications both for the pathogenesis of Chagas' disease and for transplantation immunology.
Vercelli
C A
CA
Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Hidalgo
A M
AM
Hyon
S H
SH
Argibay
P F
PF
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D017690:Cell Transplantation / Q000379:methods*; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D009439:Neuraminidase / Q000494:pharmacology*; D014181:Transplantation Immunology; D014349:Trypanosoma cruzi / Q000201:enzymology*
D015703:Antigens, CD; D006023:Glycoproteins; C069715:trans-sialidase; D009439:Neuraminidase