title: Autologous peripheral blood stem cell transplantation for POEMS syndrome.
abstract: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Japan. kuwabara-s@faculty.chiba-u.jp
authors.forename: S
authors.initials: S
authors.lastname: Kuwabara
authors.forename: S
authors.initials: S
authors.lastname: Misawa
authors.forename: K
authors.initials: K
authors.lastname: Kanai
authors.forename: Y
authors.initials: Y
authors.lastname: Kikkawa
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: C
authors.initials: C
authors.lastname: Nakaseko
authors.forename: R K
authors.initials: RK
authors.lastname: Cho
authors.forename: T
authors.initials: T
authors.lastname: Hattori
mesh_terms: D000328:Adult; D000368:Aged; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use*; D016878:POEMS Syndrome / Q000503:physiopathology / Q000628:therapy*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D010954:Plasmacytoma / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism
chemical_list: D019653:Myeloablative Agonists; D042461:Vascular Endothelial Growth Factor A; D008558:Melphalan