title: Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease.
abstract: OBJECTIVE
  To investigate for the first time whether the plasma CXCL16 concentration is altered in coronary artery disease (CAD) patients.
  
  
  BACKGROUND
  Accumulating evidence suggests that the novel chemokine/scavenger receptor CXCL16/SR-PSOX is involved in the development of atherosclerosis and CAD.
  
  
  METHODS
  Using ELISA we assessed the plasma CXCL16 concentration in 40 stable angina pectoris (SAP) patients, 17 unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/non-STEMI) patients, 387 survivors of a first myocardial infarction (MI) and healthy control subjects (44 controls for SAP and UAP/non-STEMI patient groups and 387 controls for post-MI patients).
  
  
  RESULTS
  SAP patients exhibited significantly lower median CXCL16 levels (2111 pg/ml) than the corresponding control subjects (2678 pg/ml) (P=0.0012). UAP/non-STEMI patients also appeared to have lower CXCL16 levels (2192 pg/ml) compared with controls (NS). Patients investigated 3 months after MI tended (P=0.07) to have lower CXCL16 levels (2529 pg/ml) than the corresponding controls (2638 pg/ml). There were no significant correlations between CXCL16 levels and different measures of CAD severity determined by quantitative coronary angiography in post-MI patients. Neither patients nor controls exhibited significant correlations between CXCL16 levels and plasma lipoprotein fractions, inflammatory cytokines, C-reactive protein or numbers of inflammatory cells in peripheral blood.
  
  
  CONCLUSIONS
  The finding that lower plasma CXCL16 concentration is associated with CAD might indicate a potential atheroprotective function of CXCL16.
authors.affiliation: Experimental Cardiovascular Research Unit, Center for Molecular Medicine, L8:03, S-17176, Karolinska University Hospital, Stockholm, Sweden. yuri.sheikine@cmm.ki.se
authors.forename: Yuri
authors.initials: Y
authors.lastname: Sheikine
authors.forename: Charlotte Sahlberg
authors.initials: CS
authors.lastname: Bang
authors.forename: Lennart
authors.initials: L
authors.lastname: Nilsson
authors.forename: Ann
authors.initials: A
authors.lastname: Samnegård
authors.forename: Anders
authors.initials: A
authors.lastname: Hamsten
authors.forename: Lena
authors.initials: L
authors.lastname: Jonasson
authors.forename: Per
authors.initials: P
authors.lastname: Eriksson
authors.forename: Allan
authors.initials: A
authors.lastname: Sirsjö
mesh_terms: D001774:Blood Chemical Analysis; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D051116:Receptors, Scavenger / Q000097:blood*; D018709:Statistics, Nonparametric; D013548:Sweden
chemical_list: C423727:CXCL16 protein, human; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger