title: Vitamin E in the treatment of uveitis-associated macular edema.
abstract: OBJECTIVE
  To investigate whether high-dose alpha-tocopherol (vitamin E) could reduce vision loss and retinal thickening associated with uveitis-associated cystoid macular edema.
  
  
  METHODS
  A double-masked, randomized study.
  
  
  METHODS
  Uveitis patients with macular edema seen at the NIH were randomized and received either 1600 IU/day of vitamin E or placebo for 4 months. Visual acuity and retinal thickening were collected for the efficacy and the safety of the high dose of vitamin E.
  
  
  RESULTS
  Changes in visual acuity and retinal thickening.
  
  
  CONCLUSIONS
  Four-month oral supplementation with 1600 IU/d of vitamin E had no apparent effect on uveitis-associated macular edema or visual acuity in this small study.
authors.affiliation: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Rm. 10S219, 10 Center Drive, Bethesda, MD 20892, USA. drbob@nei.nih.gov
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: Jonghyeon
authors.initials: J
authors.lastname: Kim
authors.forename: Darby J S
authors.initials: DJ
authors.lastname: Thompson
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Davis
authors.forename: Emily
authors.initials: E
authors.lastname: Chew
authors.forename: Frederick L
authors.initials: FL
authors.lastname: Ferris
authors.forename: Ronald
authors.initials: R
authors.lastname: Buggage
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000187:drug effects; D014605:Uveitis / Q000150:complications / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D014810:Vitamin E