Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region.
Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.
Shin
Joo-Ho
JH
Department of Pediatrics, Division of Neuroproteomics, Medical University of Vienna, Austria. gert.lubec@meduniwien.ac.at
Gulesserian
Talin
T
Verger
Emmanuelle
E
Delabar
Jean-Maurice
JM
Lubec
Gert
G
D000818:Animals; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D014176:Protein Biosynthesis / Q000235:genetics; D011506:Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D020543:Proteome / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism
D011506:Proteins; D020543:Proteome; D012333:RNA, Messenger