Globular adiponectin activates nuclear factor-kappaB in vascular endothelial cells, which in turn induces expression of proinflammatory and adhesion molecule genes.
Hattori
Yoshiyuki
Y
Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, 321-0293, Japan. yhattori@dokkyomed.ac.jp
Hattori
Sachiko
S
Kasai
Kikuo
K
D052242:Adiponectin / Q000494:pharmacology*; D015815:Cell Adhesion Molecules / Q000235:genetics; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000187:drug effects / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects; D014471:Umbilical Veins
D052242:Adiponectin; D015815:Cell Adhesion Molecules; D016207:Cytokines; D016328:NF-kappa B