title: Nosocomial invasive infection caused by Cunninghamella bertholletiae: case report.
abstract: Human infection by Cunninghamella bertholletiae occurs almost exclusively in immunocompromised patients. Infections due to this microorganism have been most frequently diagnosed in patients with hematological malignancies, with neutropenia and in diabetes mellitus patients. This work reports a case of fungal infection by Cunninghamella bertholletiae isolated from blood in a man with a complex clinical picture, involving diabetes and pharmacological immunosupression. Blood culture at room temperature and at 37 degrees C on Sabouraud agar grew a single mold with characteristic properties of Cunninghamella. In the microscopic morphology, were found wide, non-septate, branching hyphae with erect sporangiophores terminated in swollen vesicles and sporangioles borne off the vesicles. C. bertholetiae was identified after subculture on Sabouraud dextrose agar at 45 degrees C. The patient died 15 days after the beginning of amphotericin B therapy.
authors.affiliation: Universidade Paulista, Goiania, Goias, Brazil.
authors.forename: Xisto Sena
authors.initials: XS
authors.lastname: Passos
authors.forename: Werther Souza
authors.initials: WS
authors.lastname: Sales
authors.forename: Patrícia Jackeline
authors.initials: PJ
authors.lastname: Maciel
authors.forename: Carolina Rodrigues
authors.initials: CR
authors.lastname: Costa
authors.forename: Denise Milioli
authors.initials: DM
authors.lastname: Ferreira
authors.forename: Maria Rosário Rodrigues
authors.initials: MR
authors.lastname: do Silva
mesh_terms: D003428:Cross Infection / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D020093:Cunninghamella / Q000254:growth & development*; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy / Q000276:immunology*