Expedited palladium-catalyzed amination of aryl nonaflates through the use of microwave-irradiation and soluble organic amine bases.
[reaction: see text] Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using the soluble amine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) or MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene) and ligands (1-3) resulted in good to excellent yields (71-99%) of arylamines in short reaction times (1-45 min).
Tundel
Rachel E
RE
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Anderson
Kevin W
KW
Buchwald
Stephen L
SL
D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D004583:Electrons; D007097:Imines / Q000737:chemistry; D008024:Ligands; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012995:Solubility
D000588:Amines; D007097:Imines; D008024:Ligands; D010165:Palladium