Determination of oxidative metabolism in Collembolan Proisotoma minuta (Tullberg).
An oxidative metabolism of Collembolan Proisotoma minuta was determined with a model compound of aldrin and dieldrin in this paper. The seven-day LD(50) values for aldrin, dieldrin, and piperonyl butoxide in salt solution were 0.496, 0.367, and 8.346 mg L(-1), respectively. When P. minuta were exposed to aldrin, dieldrin was the sole metabolite. The conversion of aldrin to dieldrin was known to be catalyzed by P450 monooxygenases system. It has been shown that the synergist piperonyl butoxide inhibited the metabolism of aldrin in P. minuta.
Park
Eun-Kee
EK
Department of Entomology and Cancer Research Center, University of California, Davis, California 95616, USA. ekpark@ucdavis.edu
Lees
Edith M
EM
D000452:Aldrin / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D004026:Dieldrin / Q000378:metabolism / Q000633:toxicity; D007313:Insecta / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D007306:Insecticides / Q000378:metabolism* / Q000633:toxicity*; D007928:Lethal Dose 50; D010084:Oxidation-Reduction; D010882:Piperonyl Butoxide / Q000378:metabolism / Q000633:toxicity; D013997:Time Factors
D007306:Insecticides; D004026:Dieldrin; D010882:Piperonyl Butoxide; D000452:Aldrin