Do young women with polycystic ovary syndrome show early evidence of preclinical coronary artery disease?
BACKGROUND
It is thought that women with polycystic ovary syndrome (PCOS) are at increased risk of developing cardiovascular diseases.


METHODS
In this study, we used transthoracic echocardiography to measure coronary flow reserve (CFR) in 28 women with PCOS and in 26 healthy women.


RESULTS
The PCOS and the control groups were similar in terms of age (27.1 +/- 4.5 versus 28.8 +/- 4.4 years) and BMI (26.6 +/- 5.7 versus 24.7 +/- 4.4 kg/m2). Fasting insulin levels and homeostasis model assessment insulin resistance index were higher in the PCOS group. LH, the LH/FSH ratio, total testosterone, free testosterone and androstenedione were higher in the PCOS group. FSH, estradiol, prolactin, progesterone, cholesterol, triglyceride and high-sensitive C-reactive protein were similar between the two groups, but homocysteine levels were higher in the PCOS group. Baseline diastolic peak f low velocity (DPFV) (25.0 +/- 4.6 versus 23.3 +/- 2.7 cm/s, P > 0.05), hyperaemic DPFV (71.2 +/- 12.8 versus 73.0 +/- 12.9 cm/s, P > 0.05) and CFR (2.8 +/- 0.8 versus 3.2 +/- 0.8 cm/s, P > 0.05) of the left anterior descending coronary artery were similar between the two groups.


CONCLUSIONS
We conclude that in young women with PCOS and without cardiovascular risk factors, CFR is preserved.
Topcu
Semra
S
Cardiology Department and Obstetrics & Gynecology Department, Konya Teaching and Medical Research Center, Baskent University, Konya, Turkey. semratopcu2003@yahoo.com
Caliskan
Mustafa
M
Ozcimen
Emel Ebru
EE
Tok
Derya
D
Uckuyu
Ayla
A
Erdogan
Dogan
D
Gullu
Hakan
H
Yildirir
Aylin
A
Zeyneloglu
Hulusi
H
Muderrisoglu
Haldun
H
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis; D004452:Echocardiography; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D014280:Triglycerides / Q000097:blood
D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D007328:Insulin; D014280:Triglycerides; D006710:Homocysteine; D002097:C-Reactive Protein; D002784:Cholesterol