Sequential pericyclic reaction of ene-diallenes: an efficient approach to the steroid skeleton.
[reaction: see text] The one-pot construction of polycyclic aromatic systems from acyclic ene-bis(propargyl alcohols) was achieved through a tandem dual [2,3]-sigmatropic rearrangement/6pi-electrocyclic reaction/intramolecular [4 + 2] cycloaddition sequence. A steroidal compound was conveniently synthesized using the present method.
Kitagaki
Shinji
S
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Japan. kitagaki@p.kanazawa-u.ac.jp
Ohdachi
Kazuhiro
K
Katoh
Kumiko
K
Mukai
Chisato
C