[Study on pharmacodynamics of run chang tong bian granules].
OBJECTIVE
To study the effect of Run Chang Tong Bian Granules (RCTBG) on stomach and intestine peristalsis in mice and rabbits.


METHODS
We conducted the intestine peristalsis test and gastric emptying test to observe the purgative action of RCTBG and the effect on isolated intestine of rabbits.


RESULTS
RCTBG could effectively expedite the advance speed of charcoal powder in the small intestine and improve the velocity of intestine. It could also reduce the residual rate of methyl orange in stomach and improve the velocity of gastric emptying. RCTBG could remarkably shorten the time of defecation, increase excrement quantity of mice, excite the isolated intestine of rabbits and increase its tension and contraction amplitude.


CONCLUSIONS
RCTBG has remarkable effect on catharsis.
Yu
Liping
L
Drug development center of Sun Yet-sen University, Guangzhou.
Wen
Jie
J
Sun
Sulan
S
Ye
Qingshan
Q
D000818:Animals; D003672:Defecation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010528:Peristalsis / Q000187:drug effects; D011817:Rabbits
D004365:Drugs, Chinese Herbal