Role of the aldosterone-sensitive distal nephron in the sodium retention associated with liver cirrhosis.
The renal mechanisms underlying sodium retention during liver cirrhosis have been difficult to elucidate. Kim and associates describe a biphasic pattern of regulation of the renal epithelial sodium channel in the common bile duct ligation model, shedding some light on this issue.
Ecelbarger
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CA
Department of Medicine, Division of Endocrinology and Metabolism, Georgetown University, Washington, DC 20057-1412, USA. ecelbarc@georgetown.edu
D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000032:analysis / Q000502:physiology; D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D053503:Epithelial Sodium Channels; D007686:Kidney Tubules, Distal / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism*; D009399:Nephrons / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000502:physiology
D053503:Epithelial Sodium Channels; D015222:Sodium Channels; D000450:Aldosterone; D012964:Sodium; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2