Psychiatric side effects of interferon-beta in multiple sclerosis.
Psychiatric disorders, especially depression, are frequent in patients with multiple sclerosis (MS). They are attributed both to the psychosocial impact of a chronic, usually progressive, disabling illness and to cerebral demyelination. Besides, drugs such as corticosteroids and possibly interferon (IFN) may also have depressogenic effects. Major depressive disorders and/or suicidal ideation are a major concern and efforts to identify and minimize these reactions are of much importance. Psychiatric side effects, particularly depression, are widely reported with IFN-alpha and have been suspected with IFN-beta but are not yet fully established. Our review of the literature revealed that most studies discard an association between IFN-beta and depression or suicide. However, few patients, especially those with a history of depression, might be at higher risk for depression when treated with IFN-beta. Overall, considering the uncertainty of a link between IFN-beta and depression and/or suicide, as well as the complete remission of psychiatric complications after IFN discontinuation and/or antidepressant treatment, physicians should closely monitor the psychiatric status of patients, but should not refrain from including them in IFN-beta treatment programs, even when they have past or present depression.
Goeb
J-L
JL
Service de Psychiatrie de l'Enfant et de l'Adolescent, CHRU, 2, avenue Oscar-Lambret, F-59037 Lille, France. jlgoeb@wanadoo.fr
Even
C
C
Nicolas
G
G
Gohier
B
B
Dubas
F
F
Garré
J B
JB
D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D003866:Depressive Disorder / Q000139:chemically induced / Q000209:etiology / Q000523:psychology*; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects*; D019964:Mood Disorders / Q000139:chemically induced / Q000209:etiology / Q000523:psychology; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D011618:Psychotic Disorders / Q000209:etiology / Q000523:psychology; D012307:Risk Factors; D013405:Suicide / Q000523:psychology
D000276:Adjuvants, Immunologic; D016899:Interferon-beta