Ochronotic arthropathy: disappearance of alkaptonuria after liver transplantation for hepatitis B-related cirrhosis.
The deficiency of homogentisic acid oxidase, an enzyme that is mainly found in hepatocytes, is associated with alkaptonuria and ochronosis. We report a patient with clinical and radiologic findings of ochronotic arthropathy in whom alkaptonuria disappeared and the progressive course of the disease stopped after liver transplantation for hepatitis B-related cirrhosis.
Kobak
Arzu Celebi
AC
Department of Medicine, Section of Gastroenterology and Hepatology, Ege University, School of Medicine, Bornova, Izmir, Turkey. arzukobak@yahoo.com
Oder
Gonca
G
Kobak
Senol
S
Argin
Mehmet
M
Inal
Vedat
V
D000474:Alkaptonuria / Q000150:complications* / Q000000981:diagnostic imaging / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000150:complications*; D006713:Homogentisic Acid / Q000652:urine; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008159:Lumbar Vertebrae; D008875:Middle Aged; D009794:Ochronosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000652:urine; D011859:Radiography; D025241:Spondylarthritis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000652:urine
D006713:Homogentisic Acid