title: Newer antipsychotics and glucose metabolism: a comparison between olanzapine and risperidone.
abstract: In order to estimate the degree of glucose tolerance impairment, oral glucose tolerance test was conducted in the group of 15 schizophrenic patients taking olanzapine, the group of 15 schizophrenic patients taking risperidone and in the group of 14 healthy volunteers. In the olanzapine group the tolerance was impaired in 33% of the patients, contrary to the risperidone group in which impairment amounted to 20% of the patients. The authors discuss possible mechanisms responsible for impaired glucose tolerance in patients taking newer antipsychotic drugs.
authors.affiliation: Psychiatric Clinic, Clinical Hospital Osijek, Croatia. filakovic.pavo@kbo.hr
authors.forename: Pavo
authors.initials: P
authors.lastname: Filaković
authors.forename: Davor
authors.initials: D
authors.lastname: Laufer
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Radanović-Grgurić
authors.forename: Oliver
authors.initials: O
authors.lastname: Koić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Fijacko
authors.forename: Marta
authors.initials: M
authors.lastname: Durković
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000139:chemically induced*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D012306:Risk; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine