title: Removal of zero-quantum peaks from 1D selective TOCSY and NOESY spectra.
abstract: Selective 1D TOCSY and NOESY experiments are widely used for structure determination. However, they often give distorted peak shapes owing to coherence transfer though zero-quantum coherence (ZQ) which cannot be suppressed by conventional phase cycling or pulse-field gradients. This paper demonstrates that ZQ contributions can be removed from selective 1D spectra by introducing a ZQ evolution time, as previously demonstrated for 2D NOESY spectra by Wang et al. [A three-dimensional method for the separation of zero-quantum coherence and NOE in NOESY spectra, J. Magn. Reson. A 102 (1993) 116-121]. This approach is simple to implement and robust, and is not demanding of spectrometer hardware. Using a new approach to phase cycling described here, spectra can be acquired in a similar time to spectra without a ZQ evolution time.
authors.affiliation: Analytical Sciences, Syngenta, Jealott's Hill Research Centre, Bracknell, Berkshire RG42 6EY, UK. peter.howe@syngenta.com
authors.forename: Peter W A
authors.initials: PW
authors.lastname: Howe