title: Oxcarbazepine in the treatment of child psychiatric disorders: a retrospective chart review.
abstract: Though not considered a first-line treatment, oxcarbazepine has become an option in the expanding effort to ameliorate severely dysregulated mood and behavioral symptoms in youth. Like most pharmaceuticals in child and adolescent psychiatry, oxcarbazepine is not U.S. Food and Drug Administration (FDA)-approved for the treatment of psychiatric disorders. A search of the world literature found a single case report pertaining to this topic. This paper is a chart review of 14 children and adolescents treated with oxcarbazepine who presented with moderate to severe problems with anger and irritability associated with a range of Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) diagnoses. A majority (70%) of patients was treatment-resistant to prior psychopharmacologic efforts, and 70% were receiving combined treatment with other agents in addition to oxcarbazepine. Moderate clinical global improvement was reported in 50% of patients receiving oxcarbazepine; tolerability was good in 86%.
authors.affiliation: Division of Child & Adolescent Psychiatry, SUNY Upstate Medical University, Syracuse, New York 13210, USA. StallerJ@upstate.edu
authors.forename: Jud A
authors.initials: JA
authors.lastname: Staller
authors.forename: Arun
authors.initials: A
authors.lastname: Kunwar
authors.forename: Mihai
authors.initials: M
authors.lastname: Simionescu
mesh_terms: D000293:Adolescent; D000786:Anger / Q000187:drug effects; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007508:Irritable Mood / Q000187:drug effects; D008297:Male; D019964:Mood Disorders / Q000188:drug therapy*; D000078330:Oxcarbazepine; D019233:Retreatment; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D002220:Carbamazepine; D000078330:Oxcarbazepine