title: Quantification of infant exposure to celecoxib through breast milk.
abstract: OBJECTIVE
  To determine the milk-to-plasma (M/P) concentration ratio of celecoxib, and estimate likely infant exposure.
  
  
  METHODS
  Blood and milk were sampled for 48 h after oral administration of celecoxib 200 mg to six lactating volunteers. The M/P ratio was derived from the area under the concentration-time curves (0-infinity) and the infant 'dose' estimated from celecoxib concentrations in milk.
  
  
  RESULTS
  The median (range) M/P ratio was 0.18 (0.15-0.26). The median (range) infant 'dose' was 0.23% (0.17-0.30%) of the maternal dose, adjusted for weight.
  
  
  CONCLUSIONS
  The relative 'dose' of celecoxib to which infants are exposed via milk is very low, suggesting that breastfeeding during routine dosing would pose minimal risk.
authors.affiliation: Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand. sharon.gardiner@cdhb.govt.nz
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Gardiner
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Doogue
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Begg
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D019540:Area Under Curve; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007774:Lactation; D008895:Milk, Human / Q000737:chemistry*; D009035:Mothers; D011720:Pyrazoles / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib