title: The first examples of Nazarov cyclizations leading to annulated pyrroles.
abstract: [reaction: see text] Reactions between alpha-substituted unsaturated carboxylic acids 20 and N-tosylpyrroles [14, 23] in the presence of trifluoroacetic anhydride result in smooth alpha-acylation of the pyrrole, followed by Nazarov cyclization to give 50-80% yields of cyclopenta[b]pyrroles. The presence of an alpha-substituent in the unsaturated acid appears to be mandatory.
authors.affiliation: School of Chemistry, Cardiff University, Main College, UK.
authors.forename: Chuanjun
authors.initials: C
authors.lastname: Song
authors.forename: David W
authors.initials: DW
authors.lastname: Knight
authors.forename: Maria A
authors.initials: MA
authors.lastname: Whatton