title: Immune responses to Aspergillus fumigatus infections.
abstract: Aspergillus fumigatus is an important fungal pathogen of the immunocompromised host. Innate inflammatory and adaptive T cell responses contribute to defense against this pathogen. Toll-like receptors are involved in the activation of innate immune defenses against fungal spores and hyphae and contribute to the recruitment of inflammatory cells to sites of infection. T cell responses to A. fumigatus are rapid and robust, and their differentiation is influenced by the metabolic activity of spores. Ongoing investigations of immune responses to A. fumigatus are likely to provide opportunities to enhance defenses against this pathogen in the immunocompromised host.
authors.affiliation: Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Amariliz
authors.initials: A
authors.lastname: Rivera
authors.forename: Tobias
authors.initials: T
authors.lastname: Hohl
authors.forename: Eric G
authors.initials: EG
authors.lastname: Pamer
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D016867:Immunocompromised Host / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D013172:Spores, Fungal / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D051193:Toll-Like Receptors