Radiation-induced osteosarcoma and papillary carcinoma of the thyroid.
OBJECTIVE
This article describes a patient with dual radiation-induced malignancies after treatment of neuroblastoma.


METHODS
A 12-year-old boy with a history of neuroblastoma was treated with chemotherapy, I-131 MIBG, and radiotherapy at age 4. He was disease-free for 8 years, but then developed left shoulder pain resulting from osteosarcoma. A thyroid malignancy was discovered during the evaluation.


RESULTS
The patient was treated with thyroidectomy and then chemotherapy according to a Children's Cancer Group Study protocol.


CONCLUSIONS
Radiation-induced sarcoma should be suspected whenever a patient who has received radiation several years previously presents with pain or swelling in the irradiated area.
Tonakie
Adam
A
Department of South Coast Radiology, Mermaid Beach, Australia. barry.shulkin@stjude.org
Shulkin
Barry L
BL
Sisson
James C
JC
Yanik
Gregory A
GA
Hutchinson
Raymond J
RJ
D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000209:etiology*; D002648:Child; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging* / Q000209:etiology; D009447:Neuroblastoma / Q000532:radiotherapy / Q000628:therapy; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000209:etiology*; D011877:Radionuclide Imaging; D011878:Radiotherapy / Q000009:adverse effects*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology*