title: Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.
abstract: Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.
authors.affiliation: Public Health Research Institute, 225 Warren St., Newark, New Jersey 07103, USA.
authors.forename: Xilin
authors.initials: X
authors.lastname: Zhao
authors.forename: Muhammad
authors.initials: M
authors.lastname: Malik
authors.forename: Nymph
authors.initials: N
authors.lastname: Chan
authors.forename: Alex
authors.initials: A
authors.lastname: Drlica-Wagner
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Wang
authors.forename: Xinying
authors.initials: X
authors.lastname: Li
authors.forename: Karl
authors.initials: K
authors.lastname: Drlica
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D002701:Chloramphenicol / Q000494:pharmacology; D004265:DNA Helicases / Q000235:genetics*; D004261:DNA Replication / Q000187:drug effects*; D053488:DnaB Helicases; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D015363:Quinolones / Q000494:pharmacology*; D013696:Temperature
chemical_list: D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D015363:Quinolones; D002701:Chloramphenicol; D004265:DNA Helicases; D053488:DnaB Helicases