title: FR177391, a new anti-hyperlipidemic agent from Serratia. I. Taxonomy, fermentation, isolation, physico-chemical properties, structure elucidation and biological activities.
abstract: In the course of screening for a new anti-hyperlipidemic agent from microbial products, we found that FR177391, produced by Serratia liquefaciens No. 1821, alleviated the decrease in lipid droplet formation in differentiated 3T3-L1 adipocyte cells, induced by the addition of tumor necrosis factor-alpha. Structural elucidation by spectroscopic methods and X-ray crystallographic analysis of its propylamide derivative revealed that FR177391 was a chlorinated macrocyclic lactone.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co Ltd, Tsukuba, Ibaraki, Japan. bunji.sato@jp.astellas.com
authors.forename: Bunji
authors.initials: B
authors.lastname: Sato
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujita
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Seiji
authors.initials: S
authors.lastname: Yoshimura
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Terano
mesh_terms: D000085:Acetates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005285:Fermentation; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D012705:Serratia / Q000737:chemistry* / Q000145:classification / Q000378:metabolism
chemical_list: D000085:Acetates; C508031:FR177391; D006571:Heterocyclic Compounds; D000960:Hypolipidemic Agents