title: Iloprost infusion in diabetic patients with peripheral arterial occlusive disease and foot ulcers.
abstract: The aim of the study was to evaluate iloprost infusion as an alternative to open surgical revascularisation in diabetic patients with foot ulcers, also as a support measure in conjunction with endovascular procedures. We studied 244 patients with critical ischaemia of the lower limbs, 146 of whom (59.8%) affected by diabetes. A femoro-distal bypass was performed in 175 patients. In the 69 nonsurgical diabetic patients (47.3% of the diabetics) an iloprost infusion was started. These diabetics presented foot ulcers, a palpable or slightly hypo-sphygmic popliteal pulse and high distal arterial flow at the ankle. In 55 of these patients (79.7% of those not operated on and 37.6% of the diabetics) who were non-responders to medical therapy, an endovascular procedure was also performed. The results of the iloprost infusion (69 pts.) were evaluated after one week. In 14 responders treated only with iloprost infusion, complete healing of the lesions occurred during the 3 weeks following the end of the 4-week course of therapy. No severe ischaemia recurrences were reported in the follow-up of these 69 patients. In the 47.3% of subjects with diabetic arteriopathy presenting foot ulcers and high distal flow, it proved possible to avoid an open surgical revascularisation procedure and to resort to medical therapy with iloprost, completed in 79.7% of cases with endovascular procedures. Iloprost infusion improves limb perfusion and, in selected cases may be an important therapeutic tool for the care of ulcerative lesions of the diabetic foot, also as a support measure in conjunction with endovascular procedures.
authors.affiliation: Cattedra e UOC di Chirurgia Vascolare, Dipartimento di Scienze Toraciche e Cardiovascolari, Policlinico Universitario di Messina.
authors.forename: Francesco
authors.initials: F
authors.lastname: Mirenda
authors.forename: Michele
authors.initials: M
authors.lastname: La Spada
authors.forename: Domenico
authors.initials: D
authors.lastname: Baccellieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Stilo
authors.forename: Filippo
authors.initials: F
authors.lastname: Benedetto
authors.forename: Francesco
authors.initials: F
authors.lastname: Spinelli
mesh_terms: D000800:Angioplasty, Balloon / Q000379:methods; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D048909:Diabetes Complications / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D017719:Diabetic Foot / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use*; D007260:Infusion Pumps; D007866:Leg / Q000098:blood supply; D023821:Limb Salvage; D012189:Retrospective Studies; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost