title: Intraoperative jugular bulb desaturation during acute aneurysmal rupture.
abstract: OBJECTIVE
  To describe an episode of acute jugular venous desaturation during intraoperative rupture of a cerebral aneurysm.
  
  
  METHODS
  A 57-yr-old patient was scheduled for clipping of a large unruptured basilar tip aneurysm. Abrupt bulging of the brain was observed after bone flap removal, but before dura was opened. This was associated with concurrent development of systemic hypertension to 200/120 mmHg and jugular venous bulb (S(jv)O(2)) desaturation to 13%. Rupture of aneurysm was confirmed by frank blood in cerebrospinal fluid drainage from the lumbar subarachnoid catheter.
  
  
  CONCLUSIONS
  Abrupt S(jv)O(2) desaturation prior to dural opening may suggest an acute increase in intracranial pressure, which in our case followed aneurysmal rupture; the systemic response to increased intracranial pressure (Cushing's response) may be ineffective in maintaining cerebral perfusion.
authors.affiliation: Harborview Medical Center, Box 359724, 325 Ninth Avenue, Seattle, Washington 98104-2499, USA. irozet@u.washington.edu
authors.forename: Irene
authors.initials: I
authors.lastname: Rozet
authors.forename: David W
authors.initials: DW
authors.lastname: Newell
authors.forename: Arthur M
authors.initials: AM
authors.lastname: Lam
mesh_terms: D000208:Acute Disease; D017542:Aneurysm, Ruptured / Q000503:physiopathology* / Q000601:surgery; D002560:Cerebrovascular Circulation; D017809:Fatal Outcome; D006801:Humans; D006973:Hypertension / Q000209:etiology; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000601:surgery; D007427:Intracranial Pressure; D007431:Intraoperative Complications / Q000601:surgery; D007601:Jugular Veins / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*
chemical_list: D010100:Oxygen