A new method of evaluating antitumor activity from measured tumor volumes.
In studies of antitumor activity, measurement of tumor growth delay is commonly used to evaluate treatment effects. However, this measurement sometimes provides no information. We propose an approach for comparing tumor response by using nonparametric regression. In a xenograft model, we found that a significant difference between two treatment effects was undetectable by comparison of tumor growth delays. The results of our finding suggest that measurements used to evaluate the treatment effects should be carefully selected in analyses of antitumor activity.
Liang
Hua
H
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 630 Rochester, NY 14642, USA. hliang@bst.rochester.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology*; D003627:Data Interpretation, Statistical; D051379:Mice; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents