Antifungal flavonoids from Hildegardia barteri.
A new isoflavan, (3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan, hildegardiol (1), and two known flavonoids, 2-hydroxymaackiain (2) and farrerol (3), were isolated from the antifungal root extract of Hildegardia barteri. The pterocarpan 2 was largely responsible for the observed antifungal activity.
Meragelman
Tamara L
TL
Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA.
Tucker
Kenneth D
KD
McCloud
Thomas G
TG
Cardellina
John H
JH
Shoemaker
Robert H
RH
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019660:Malvaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013636:Tanzania
C506996:(3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan; D000935:Antifungal Agents; D002867:Chromones; D005419:Flavonoids; D007529:Isoflavones; C015881:farrerol