Doubling up on microtubule stabilizers: synergistic functions of doublecortin-like kinase and doublecortin in the developing cerebral cortex.
Dynamic regulation of neuronal cytoskeletal machinery in response to extracellular cues enables distinct changes in neuronal development in the cerebral cortex. In this issue of Neuron, three related studies on doublecortin-like kinase, a microtubule-associated protein related to doublecortin, by Shu et al., Koizumi et al., and Deuel et al., provide evidence that doublecortin-like kinase is essential for proper neurogenesis, neuronal migration, and axonal wiring.
Weimer
Jill M
JM
Neuroscience Center, Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
Anton
E S
ES
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D002540:Cerebral Cortex / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D000089622:Doublecortin Domain Proteins; D000089742:Doublecortin-Like Kinases; D004357:Drug Synergism; D004622:Embryo, Mammalian / Q000378:metabolism; D004625:Embryo, Nonmammalian; D047108:Embryonic Development; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*
D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D000089742:Doublecortin-Like Kinases; C485525:Dclk1 protein, mouse; D017346:Protein Serine-Threonine Kinases