[Effect on pharmacokinetics of pseudo-ephedrine in human plasma among herbs in Mahuang decoction].
OBJECTIVE
To develop a GC-MS method for the determination of pseudo-ephedrine in human plasma and study the mutative rules of the pharmacokinetic parameters of the pseudo-ephedrine in different compositions.


METHODS
Orthogonal design was used to determine 8 compositions from Mahuang decoction (MHD). The healthy volunteers were divided into groups in random, each group including 8 men. After taking the medicine orally, vena blood would be taken out at different time. Determining pseudo-ephedrine in plasma and plotting the concentration-time curve, the pharmacokinetic parameters of each composition were calculated by WinNonlin 4.0.1. The statistical analysis of the pharmacokinetic parameters was proceeded by SPSS 10.0.


RESULTS
All concentration-time curves were adequately modeled by one compartment, first order absorption model, no lag time. Some parameters of pseudo-ephedrine showed significant variance (P < 0.05) in different compositions. The statistic results showed interactions between drugs in MHD (P < 0.05).


CONCLUSIONS
The other herbs erds of MHD have some certain extent effects to the pharmacokinetic parameters of pseudo-ephedrine in the dominant drug.
He
Feng
F
Key Laboratory of Pharmacies Research of Traditional Chinese Medicine, South Medical University, Guangzhou 510515, China.
Luo
Jia-Bo
JB
D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D027424:Cinnamomum / Q000737:chemistry; D004338:Drug Combinations; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D029789:Ephedra / Q000737:chemistry; D004809:Ephedrine / Q000302:isolation & purification / Q000493:pharmacokinetics*; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D006801:Humans; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D027861:Prunus / Q000737:chemistry; D011897:Random Allocation
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004809:Ephedrine