title: Quetiapine in the treatment of behavioral disturbances in patients with Huntington's disease.
abstract: The effect of quetiapine (an atypical antipsychotic with minimal extrapyramidal side effects) on motor as well as behavioral symptoms was studied in five consecutive patients with Huntington's disease in a long-term facility. Improvement of behavioral symptoms (i.e., psychotic symptoms, agitation, irritability, and insomnia) without worsening of motor functioning were noted.
authors.affiliation: Massachusetts General Hospital, Dept. of Psychiatry, Boston, USA. malpay@partners.org
authors.forename: Menekse
authors.initials: M
authors.lastname: Alpay
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Koroshetz
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003987:Dibenzothiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000523:psychology; D008134:Long-Term Care / Q000379:methods / Q000523:psychology; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000523:psychology; D011595:Psychomotor Agitation / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D011618:Psychotic Disorders / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D000069348:Quetiapine Fumarate
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate