Chymotrypsin inhibitory triterpenoids from Silybum marianum.
Marianine, the new lanostane triterpene (1) and marianosides A (2) and B (3) have been isolated from the whole plant of Silybum marianum. Their structures were elucidated on the basis of extensive analysis of their one dimensional and two dimensional nuclear magnetic resonance (1D, 2D-NMR) spectral data. All inhibited chymotrypsin in a concentration-dependent manner.
Ahmed
Ejaz
E
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
Malik
Abdul
A
Ferheen
Sadia
S
Afza
Nighat
N
Azhar-Ul-Haq
Lodhi
Muhammad Arif
MA
Choudhary
Muhammad Iqbal
MI
D019659:Asteraceae / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002725:Chloroform; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*
D005960:Glucosides; D010936:Plant Extracts; D012997:Solvents; D014315:Triterpenes; D014361:Trypsin Inhibitors; C508591:marianine; C508593:marianoside A; C508595:marianoside B; D002725:Chloroform; D002918:Chymotrypsin