title: Woman aged 24 years with fourth ventricular mass.
abstract: April 2005. A woman aged 24 years presented with symptoms related to a tumor in the fourth ventricle. Cytologically, the tumor was biphasic with areas typical of a classic ependymoma, including rosettes, and other areas containing grossly atypical giant cells. Many tumor cells were GFAP-positive and ultrastructural examination revealed microvilli and cilia. The histopathologic abnormalities place this tumor among the ependymomas. Its focal giant cell phenotype is very rare, but has been reported in 4 intracranial or filum ependymomas.
authors.affiliation: Department of Neuropathology, Newcastle-upon-Tyne Hospitals Trust, Newcastle-upon-Tyne, United Kingdom.
authors.forename: Piyali
authors.initials: P
authors.lastname: Pal
authors.forename: Helen
authors.initials: H
authors.lastname: Fernandes
authors.forename: David W
authors.initials: DW
authors.lastname: Ellison
mesh_terms: D000328:Adult; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D004806:Ependymoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D020546:Fourth Ventricle / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005870:Giant Cell Tumors / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D046529:Microscopy, Electron, Transmission