title: Structure-antibacterial activity relationship of secondary metabolites from Ajuga pseudoiva Rob. leaves.
abstract: A selection of steroids, glycerides, clerodane diterpenoids, and a beta-hydroxy fatty acid methyl ester, all previously isolated from Ajuga pseudoiva leaves, were tested for their antibacterial activity toward three Gram- rods and one Gram+ coccus using the dilution method; MIC values were determined. The results suggested some importance for a free beta-hydroxy group in the fatty acid ester and also in the glycerides and clerodane derivatives; the absolute configurations of the latter, notably at C2, had little influence on activity.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles et de Synthèse Organique, Faculté des Sciences de Monastir, 5019 Monastir, Tunisia.
authors.forename: Hichem
authors.initials: H
authors.lastname: Ben Jannet
authors.forename: Atef
authors.initials: A
authors.lastname: Chaari
authors.forename: Amina
authors.initials: A
authors.lastname: Bakhrouf
authors.forename: Zine
authors.initials: Z
authors.lastname: Mighri
mesh_terms: D031328:Ajuga / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts