title: Dicationic pyridium porphyrins appending different peripheral substituents: synthesis and studies for their interactions with DNA.
abstract: Twelve trans-dicationic pyridium porphyrins appending different peripheral substituents were synthesized and their abilities to bind and cleave DNA under irradiation have been investigated. Their binding modes to DNA were studied by UV-vis spectroscopy, circular dichroism. The apparent constants were measured by EB competitive fluorescence method and most of them were in the range of 10(4)-10(5) M(-1). We found that both the position of positive charges and steric hindrance could greatly influence their binding affinities and modes to DNA, and then affect their photocleaving abilities to DNA.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Lige
authors.initials: L
authors.lastname: Ren
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Tao
authors.initials: T
authors.lastname: Jia
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Cao
mesh_terms: D002412:Cations / Q000737:chemistry; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015394:Molecular Structure; D010777:Photochemistry; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*
chemical_list: D002412:Cations; D011166:Porphyrins; D011725:Pyridines; D004247:DNA; C023666:pyridine