Serum ferritin in renal cell carcinoma: effect of tumor size, volume grade, and stage.
OBJECTIVE
To study the levels of serum ferritin in patients of renal cell carcinoma (RCC).


METHODS
Serum ferritin levels were measured preoperatively in 32 patients with radiological evidence of RCC using an enzyme immunoassay. The largest diameter of the primary tumor was measured in the pathological specimens in patients undergoing radical nephrectomy while in patients with non-operable tumor maximum tumor dimension was taken from CT scan. Pathological staging was done according TNM-1997.


RESULTS
Mean serum ferritin value in patients of RCC was 283.23+/-77.38 ng/ml while in controls the mean value was 79.98+/-32.96 ng/ml (P CONCLUSIONS: Serum ferritin levels are elevated in patients with RCC although its actual source is unclear. Further studies are needed to establish the role of ferritin in RCC.
Singh
Kamal Jeet
KJ
Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. kamals@sgpgi.ac.in
Singh
S K
SK
Suri
Amit
A
Vijjan
Vivek
V
Goswami
A K
AK
Khullar
Madhu
M
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005293:Ferritins / Q000032:analysis / Q000097:blood*; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D047368:Tumor Burden
D014408:Biomarkers, Tumor; D005293:Ferritins