title: Innate sensors of microbial infection.
abstract: The innate immune system utilizes multiple families of pattern-recognition receptors (PRRs) to protect the host from infection. Each of these families contributes certain elements to the complement of innate effector functions that is elicited during an infection. Here we review the families of PRRs and explore examples of their cooperativity.
authors.affiliation: HHMI and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. diana.hargreaves@yale.edu
authors.forename: Diana C
authors.initials: DC
authors.lastname: Hargreaves
authors.forename: Ruslan
authors.initials: R
authors.lastname: Medzhitov
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D002450:Cell Communication / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007424:Intracellular Fluid / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000821:virology; D005810:Multigene Family / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology / Q000821:virology
chemical_list: D051192:Receptors, Pattern Recognition