A2B adenosine receptor antagonists: recent developments.
There are pharmacological evidences that A(2B) receptors are involved in inflammatory processes, such as asthma. For this reason, many efforts has been made for identifying selective A(2B) antagonists as anti-asthmatic agents. The updated material related to this field has been rationalised and arranged in order to offer an overview of the topic.
Cacciari
Barbara
B
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy.
Pastorin
Giorgia
G
Bolcato
Chiara
C
Spalluto
Giampiero
G
Bacilieri
Magdalena
M
Moro
Stefano
S
D058917:Adenosine A2 Receptor Antagonists; D000595:Amino Acid Sequence; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000473:pathology; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D011799:Quinazolines / Q000737:chemistry / Q000378:metabolism; D014230:Triazoles / Q000737:chemistry / Q000378:metabolism; D014970:Xanthines / Q000737:chemistry / Q000378:metabolism
D058917:Adenosine A2 Receptor Antagonists; D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D011799:Quinazolines; D014230:Triazoles; D014970:Xanthines