The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies.
The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin.
Dadwal
Mamta
M
Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
Mohan
Renu
R
Panda
Dulal
D
Mobin
Shaikh M
SM
Namboothiri
Irishi N N
IN
D000179:Acrylates / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001665:Binding Sites; D002074:Butanones / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects*; D005030:Ethylenes / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000737:chemistry; D018021:Lithium Chloride / Q000737:chemistry; D008956:Models, Chemical; D009574:Nitro Compounds / Q000737:chemistry / Q000494:pharmacology*; D013696:Temperature; D014404:Tubulin / Q000378:metabolism
D000179:Acrylates; D000475:Alkenes; D000970:Antineoplastic Agents; D002074:Butanones; D005030:Ethylenes; D005663:Furans; D007093:Imidazoles; D009574:Nitro Compounds; D014404:Tubulin; C018674:tetrahydrofuran; C029899:imidazole; C057920:3-buten-2-one; D018021:Lithium Chloride; C036658:acrylic acid