title: [Vitamin B12 deficiency. New data on an old theme].
abstract: Cobalamin deficiency is a common finding. In the elderly the prevalence is 10-20%, but only 5-10% of these are clinically symptomatic. Typical clinical symptoms include macrocytic anemia, neuropsychiatric symptoms and glossitis. In many cases this triad is lacking, however. The serum cobalamin assay is the best first line test, but the results must be carefully interpreted, since a normal level does not exclude deficiency. Markers of cobalamin activity, such as serum homocysteine or methylmalonic acid may be helpful in this situation. The main cause of cobalamin deficiency is atrophic gastritis. It is either caused by an autoimmune process which leads to achlorhydria and severe intrinsic factor deficiency ("classical pernicious anemia") or by atrophic gastritis from other causes, in particular helicobacter pylori infection. In the latter cases the lack of gastric acid does not allow separation of cobalamin from proteins, but intrinsic factor, although low, is sufficient for cobalamin protection (food cobalamin malabsorption). Helicobacter pylori eradication may cure some of these patients. While in food cobalamin malabsorption syndrome small doses of oral cobalamin are effective, parenteral therapy or high oral doses are required for treatment of pernicious anemia. While almost all patients respond hematologically, only half of the patients with neurological signs, and a small minority of psychiatric patients respond to treatment. Patients with pernicious anemia and atrophic gastritis have a greatly increased long-term risk for gastric carcinoids.
authors.affiliation: Abteilung Hämatologie und Hämostaseologie, Universitätsklinik für Innere Medizin I, Medizinische Universität Wien, Wien, Osterreich. klaus.lechner@meduniwien.ac.at
authors.forename: Klaus
authors.initials: K
authors.lastname: Lechner
authors.forename: Manuela
authors.initials: M
authors.lastname: Födinger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Grisold
authors.forename: Andreas
authors.initials: A
authors.lastname: Püspök
authors.forename: Christian
authors.initials: C
authors.lastname: Sillaber
mesh_terms: D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011379:Prognosis; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000627:therapeutic use*; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D014805:Vitamin B 12