title: Current difficulties in the diagnosis and management of spinal tuberculosis.
abstract: BACKGROUND
  The diagnosis of spinal tuberculosis (ST) is difficult and it commonly presents at an advanced stage. The management and follow up is complicated by a lack of guidance on the appropriate use and interpretation of spinal magnetic resonance studies (MR).
  
  
  OBJECTIVE
  A retrospective study was performed at a UK centre to identify the demographic and presenting features of a spinal TB population, their response to treatment, and the value of follow up MR studies.
  
  
  RESULTS
  Twenty one patients were identified with mean symptom duration of 11 (1.5-36) months having been assessed by a health practitioner on 3.2 (0-10) occasions before referral for investigation for ST. Twenty were born outside the UK. Their mean duration of residence in the UK was 6.67 (0.75-20) years, and six (32%) were resident for more than 10 years. Most (85.7%) did not have a medical history and one was HIV positive. Back pain, neurological, and constitutional symptoms were found in 100%, 29%, and 38% respectively. Musculoskeletal and neurological signs were found in 29% and 19% respectively. Spinal MR performed between 6 and 12 months suggests that six months of chemotherapy (for a fully sensitive organism) may not be sufficient to achieve disease resolution.
  
  
  CONCLUSIONS
  Awareness of the demographic, clinical, and laboratory features of an ST population may facilitate earlier diagnosis. Guidance is required on the appropriate use and interpretation of MRI in the follow up of these patients.
authors.affiliation: Department of Respiratory Medicine, Guy's and St Thomas' NHS Hospitals Trust, London, UK. liam.cormican@kingsch.nhs.co.uk
authors.forename: L
authors.initials: L
authors.lastname: Cormican
authors.forename: R
authors.initials: R
authors.lastname: Hammal
authors.forename: J
authors.initials: J
authors.lastname: Messenger
authors.forename: H J
authors.initials: HJ
authors.lastname: Milburn
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology; D014399:Tuberculosis, Spinal / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents