title: Adenoviral keratoconjunctivitis in a tertiary care eye clinic.
abstract: OBJECTIVE
  To elucidate the natural history and epidemiology of adenoviral keratoconjunctivitis as seen in a tertiary care eye clinic.
  
  
  METHODS
  In a retrospective observational case series design, the medical records of 54 consecutive patients seen over a 6-year period at the Dean McGee Eye Institute (DMEI) with a diagnosis of adenoviral keratoconjunctivitis were analyzed retrospectively. The main outcome measure was the duration of symptomatic subepithelial corneal infiltrates following onset of acute conjunctivitis.
  
  
  RESULTS
  Annual case numbers ranged from 3 each in 1997 and 1998 to 26 in 2000. No more than 5 new cases presented in any single month, and no seasonal predominance was evident. The median duration of disease was 5 weeks, but the mean was 23.4 weeks, reflecting a subset of patients with a prolonged course. Indeed, 14 (25.9%) of 54 patients demonstrated symptomatic subepithelial corneal infiltrates for more than 45 days from the first examination for conjunctivitis.
  
  
  CONCLUSIONS
  These data suggest a significant level of long-term morbidity for adenoviral keratoconjunctivitis.
authors.affiliation: Molecular Pathogenesis of Eye Infection Research Center, Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Amir Latif
authors.initials: AL
authors.lastname: Butt
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
mesh_terms: D000256:Adenoviridae; D000258:Adenovirus Infections, Human / Q000453:epidemiology* / Q000821:virology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003428:Cross Infection / Q000453:epidemiology* / Q000821:virology; D015828:Eye Infections, Viral / Q000453:epidemiology* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006782:Hospitals, Special; D006801:Humans; D015994:Incidence; D007637:Keratoconjunctivitis / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors