Autoaggressive immune-mediated movement disorders.
Poststreptococcal disorders exhibit a remarkable comorbidity of neurologic and psychiatric features. A similar combination of symptoms is also described in other conditions, such as connective tissue or paraneoplastic disorders, albeit less frequently. A better understanding of the underlying mechanisms associated with autoaggressive immune-mediated attack on the basal ganglia is required. This understanding will ideally aid clinicians in diagnosing these conditions and lead to appropriate clinical trials, for example, of chemoprophylaxis strategies to prevent recurrent streptococcal infection and of the use of immunosuppressive treatments.
Martino
Davide
D
Institute of Neurology, Department of Neuroimmunology, University College London, London, United Kingdom.
Giovannoni
Gavin
G
D001289:Attention Deficit Disorder with Hyperactivity; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D015551:Autoimmunity / Q000502:physiology*; D001480:Basal Ganglia Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002819:Chorea / Q000209:etiology; D006801:Humans; D001523:Mental Disorders / Q000209:etiology; D009069:Movement Disorders / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D009771:Obsessive-Compulsive Disorder; D020361:Paraneoplastic Syndromes, Nervous System; D013290:Streptococcal Infections / Q000150:complications; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D005879:Tourette Syndrome