title: [Treatment with topical interferon alone in severe conjunctivo-corneal neoplasia].
abstract: METHODS
  A 78-year-old man was referred for evaluation of a limbic lesion in his left eye. This had a gelatinous appearance and an extension of 240 degrees . The lesion was clinically diagnosed to be a conjunctival and corneal intraepithelial neoplasia (CIN). Topical treatment with interferon alpha2b (INFalpha2b) four times daily was started and continued until the lesion had completely resolved at 4 months.
  
  
  CONCLUSIONS
  Topical INFalpha2b alone may be a safe and effective treatment of CIN instead of the other classic alternatives such as surgical excision with cryotherapy, which could induce the development of severe limbic deficiency in cases with extensive disease.
authors.affiliation: Unidad de Córnea e Inflamación Ocular, Hospital General de Móstoles, Madrid, Spain. ddiazval@nacom.es
authors.forename: D
authors.initials: D
authors.lastname: Díaz-Valle
authors.forename: J M
authors.initials: JM
authors.lastname: Benítez-del-Castillo
authors.forename: T
authors.initials: T
authors.lastname: Díaz-Valle
authors.forename: Y
authors.initials: Y
authors.lastname: Poza-Morales
authors.forename: A
authors.initials: A
authors.lastname: Arteaga-Sánchez
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D003230:Conjunctival Neoplasms / Q000188:drug therapy*; D003316:Corneal Diseases / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D011994:Recombinant Proteins; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins