Titanium(II)-mediated cyclizations of (silyloxy)enynes: a total synthesis of (-)-7-demethylpiericidin A1.
A concise total synthesis of 7-demethylpiericidin A1 has been completed. The synthesis features a titanium(II)-mediated cyclization of a (silyloxy)enyne as the key step and proceeds in nine steps from tiglic aldehyde.
Keaton
Katie A
KA
Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309-0215, USA.
Phillips
Andrew J
AJ
D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D003500:Cyclization; D011725:Pyridines / Q000138:chemical synthesis; D012821:Silanes / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D000475:Alkenes; D000480:Alkynes; D011725:Pyridines; C101453:SN 198-D; D012821:Silanes; D014025:Titanium