title: Identification of ammonia in gas emanated from human skin and its correlation with that in blood.
abstract: Identifying and measuring the ammonia gas that emanates from human skin, which we called skin gas, has been achieved using a modified gas chromatographic system with a nitrogen-selective detector (flame-thermoionic detector: FTD). The skin gas is collected with a home-made sampling probe or bag, which is used to cover the skin surface of a subject's wrist, or a finger, for 5 min. It was proved that ammonia was present in skin gas for healthy persons and patients with hepatic disease. The average amounts of ammonia were 1.7 +/- 0.4 and 2.7 +/- 0.8 ng/cm2; furthermore, there was a significant difference between them (p < 0.05). In addition, the ammonia levels present in skin gas were correlated with that in blood (r = 0.64, p < 0.05).
authors.affiliation: Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa, Nagoya 466-8555, Japan.
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nose
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Mizuno
authors.forename: Norio
authors.initials: N
authors.lastname: Yamane
authors.forename: Takaharu
authors.initials: T
authors.lastname: Kondo
authors.forename: Hajime
authors.initials: H
authors.lastname: Ohtani
authors.forename: Shuki
authors.initials: S
authors.lastname: Araki
authors.forename: Takao
authors.initials: T
authors.lastname: Tsuda
mesh_terms: D000641:Ammonia / Q000032:analysis* / Q000097:blood; D002138:Calibration; D002849:Chromatography, Gas; D005740:Gases / Q000737:chemistry*; D006801:Humans; D012867:Skin / Q000737:chemistry*
chemical_list: D005740:Gases; D000641:Ammonia