Emergent complications following donepezil switchover to galantamine in three cases of dementia with Lewy bodies.
Delayed disease progression and symptomatic improvement occur with cholinesterase inhibitors (ChEIs) in dementia with Lewy bodies (DLB). In this study, complications (insomnia, dyskinesias, agitation, and delirium) occurred in three patients switched from donepezil to galantamine. The authors describe evidence-based recommendations for ChEI switchover in DLB.
Bhanji
Nadeem H
NH
Clinical Pharmacology Unit, Allan Memorial Institute, McGill University Health Centre, 1025 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1. nadeem.bhanji@mail.mcgill.ca
Gauthier
Serge
S
D000368:Aged; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D018450:Disease Progression; D000077265:Donepezil; D005702:Galantamine / Q000009:adverse effects*; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D020961:Lewy Body Disease / Q000188:drug therapy*; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D010880:Piperidines / Q000627:therapeutic use*
D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D005702:Galantamine; D000077265:Donepezil