title: Cytotoxic lignans from the stems of Helicteres hirsuta collected in Indonesia.
abstract: Cytotoxicity-guided fractionation of the stems of Helicteres hirsuta, of Indonesian origin, led to the isolation and identification of six lignans, namely, (+/-)-pinoresinol, (+/-)-medioresinol, (+/-)-syringaresinol, (-)-boehmenan, (-)-boehmenan H and (+/-)-trans-dihydrodiconiferyl alcohol. Of these isolates, (+/-)-pinoresinol exhibited potent cytotoxic effects when evaluated against a small panel of cancer cell lines.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: William P
authors.initials: WP
authors.lastname: Jones
authors.forename: Ismail
authors.initials: I
authors.lastname: Rachman
authors.forename: Soedarsono
authors.initials: S
authors.lastname: Riswan
authors.forename: Leonardus B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Cordell
authors.forename: Steven M
authors.initials: SM
authors.lastname: Swanson
authors.forename: John M
authors.initials: JM
authors.lastname: Cassady
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D007214:Indonesia; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D019660:Malvaceae / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D018675:Toxicity Tests
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans