title: Asymmetric synthesis of propargylamides via 3,3'-disubstituted binaphthol-modified alkynylboronates.
abstract: [reaction: see text] Alkynylboronates derived from 3,3'-disubstituted-2,2'-binaphthols react with various N-acylimines to give the expected chiral propargylamides with up to 99% ee. This new methodology was applied to the first enantioselective synthesis of the antitubulin agent (-)-N-acetylcolchinol.
authors.affiliation: Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, (GWC), Department of Chemistry, University of Waterloo, Ontario, Canada.
authors.forename: T Robert
authors.initials: TR
authors.lastname: Wu
authors.forename: J Michael
authors.initials: JM
authors.lastname: Chong