[Dynamics of cellular transformations in Candida-induced granulomas in lymph nodes after treatment with a lysosomotropic form of amphotericin B: an experimental study].
In an experiment conducted using male CBA mice, cellular events during granulomatous Candida-induced inflammation were studied both in untreated animals and in animals treated with a new lysosomotropic composition, consisting of amphotericin B in intracellularly prolonged dextran immunomodulating matrix. To induce systemic Candida granulomatous inflammation, mice were given a single 0.2 ml intraperitoneal injection of Candida albicans culture (2.5 x 10(9) microbial bodies) dissolved in 0.9% isotonic saline. The findings obtained indicate greater therapeutic effect of amphotericin B and dextran dialdehyde composition as compared with a free (unconjugated) form of amphotericin B, that was manifested by the disappearance of granulomas and the capacity to prevent the development of spontaneous destructive processes in granulomas. Independent antimycotic effect of dextran dialdehyde was also demonstrated.
Shkurupiĭ
V A
VA
Ovsianko
E V
EV
Nadeev
A P
AP
Izvekova
I Ia
IIa
Travin
M A
MA
Luzgina
N G
NG
D000666:Amphotericin B / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy*; D003911:Dextrans / Q000737:chemistry; D006099:Granuloma / Q000188:drug therapy* / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology*; D008206:Lymphatic Diseases / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D003911:Dextrans; C026948:dextran dialdehyde; D000666:Amphotericin B