title: Experimental posterior perforating ocular injury in rabbit eyes: effects of radiotherapy with or without intravitreal cyclosporin on vitreous proliferation.
abstract: Double perforating ocular injuries were made in 30 rabbits and the effects of radiotherapy (RT) alone or in combination with cyclosporin (CS) on vitreous proliferation investigated. Thirteen rabbits in group 1 received RT alone (600 cGy), and 13 rabbits in group 2 received RT combined with 100 microg of intravitreal CS. No treatment was given to 4 rabbits in the control group (group 3). All animals were ophthalmologically examined on the 1st, 3rd, 7th, 14th and 28th days following the injury and the clinical findings scored; they were sacrificed on the 28th day, and histopathological scoring was made. The median histopathological score of the RT group (4.0; range: 0-8) was significantly higher than that of the CS + RT group (1.0; range: 0-5; p = 0.018). We conclude that intravitreal CS may be used as an adjunctive agent to RT to inhibit intraocular proliferation following penetrating ocular injury in rabbits.
authors.affiliation: Department of Ophthalmology, Erciyes University Faculty of Medicine, Kayseri, Turkey. sarper@erciyes.edu.tr
authors.forename: Sarper
authors.initials: S
authors.lastname: Karakücük
authors.forename: Serdar
authors.initials: S
authors.lastname: Soyuer
authors.forename: Ayse Oztürk
authors.initials: AO
authors.lastname: Oner
authors.forename: Isin
authors.initials: I
authors.lastname: Soyuer
authors.forename: Kadir
authors.initials: K
authors.lastname: Yaray
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Mirza
authors.forename: Gülden
authors.initials: G
authors.lastname: Baskol
authors.forename: Aynur
authors.initials: A
authors.lastname: Akin
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D015807:Eye Injuries, Penetrating / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007267:Injections; D011817:Rabbits; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D018630:Vitreoretinopathy, Proliferative / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D014822:Vitreous Body
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine