title: Primary carcinosarcoma of the helix of the ear.
abstract: We report our histologic and immunohistochemical findings in a rare case of cutaneous carcinosarcoma involving the helix of the ear. The tumor exhibited cellular features of both basal cell and squamous cell carcinoma and a malignant mesenchymal component that was consistent with malignant fibrous histiocytoma. The epithelial component exhibited a positive immunohistochemical reaction to cytokeratin and a negative reaction to vimentin, whereas the mesenchymal component showed a positive immunohistochemical reaction to vimentin and a negative reaction to cytokeratin. To the best of our knowledge, this is only the third reported case of a carcinosarcoma of the ear and the second case in which it developed on the helix.
authors.affiliation: Department of Pathology, University of Miami School of Medicine, FL, USA. vvincek@med.miami.edu
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vincek
authors.forename: Marjan
authors.initials: M
authors.lastname: Mirzabeigi
authors.forename: Brian S
authors.initials: BS
authors.lastname: Jewett
authors.forename: W Jarrard
authors.initials: WJ
authors.lastname: Goodwin
mesh_terms: D000368:Aged; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004428:Ear Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004431:Ear, External; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery