Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis.
We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.
Lionakis
Michail S
MS
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA.
Chamilos
Georgios
G
Lewis
Russell E
RE
Wiederhold
Nathan P
NP
Raad
Issam I
II
Samonis
George
G
Kontoyiannis
Dimitrios P
DP
D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005670:Fusarium / Q000187:drug effects* / Q000302:isolation & purification; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D009503:Neutropenia / Q000150:complications / Q000378:metabolism; D009894:Opportunistic Infections; D010419:Pentamidine / Q000494:pharmacology / Q000627:therapeutic use*
D000935:Antifungal Agents; D010419:Pentamidine