Acceleration of murine amyloidosis by implantation of amyloid-containing grafts.
We examined the transmissibility of amyloidosis by the implantation of amyloid-containing tissue. If the transmissibility similar to prion diseases is applicable, using amyloid-containing tissue for transplantation in humans might be a risk factor. In this study, AA amyloidosis occurred in mice that underwent implantation of AA amyloid-containing grafts to the liver and subsequent inflammatory stimulation. AApoAII amyloidosis occurred after implantation of AApoAII amyloid-containing grafts to the liver or to the subcutaneous space without inflammatory stimulation. Both types of amyloidoses occurred in the recipient mice sooner than expected. Moreover, AA and AApoAII amyloid deposits were found at 12 weeks after implantation in mice given AApoAII amyloid-containing grafts and inflammatory stimulation. These results suggest that implanted amyloid deposits have an AEF effect and that implanted amyloid-containing tissue can promote and accelerate a different type of amyloidosis. In another experiment, mice received amyloid-containing or normal tissue grafts. The degree of amyloid deposition was compared after 6 days and 5 weeks of inflammatory stimulation and when the mice were killed. There was no obvious difference in the degree of amyloid deposition between each group, indicating that the lag-time is shortened by implantation of amyloid-containing tissue, resulting in severe amyloidosis in the short term.
Ono
Sayako
S
First Department of Pathology, Yamaguchi University Hospital, Japan. s-ono@umin.ac.jp
Cui
Dan
D
Kunitsugu
Ichiro
I
Hoshii
Yoshinobu
Y
Kawano
Hiroo
H
Takahashi
Mutsuo
M
Gondo
Toshikazu
T
Ishihara
Tokuhiro
T
D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D016633:Apolipoprotein A-II / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008806:Mice, Inbred AKR; D008813:Mice, Inbred ICR; D016378:Tissue Transplantation; D019737:Transplants / Q000009:adverse effects*
D000682:Amyloid; D016633:Apolipoprotein A-II