Does yeast shmooing mean a commitment to apoptosis?
Treatment of yeast Saccharomyces cerevisiae with alpha-pheromone has been reported to lead to massive apoptosis of cells finding no conjugation partner [Severin FF, Hyman AA. Pheromone induces programmed cell death in S. cerevisiae. Curr Biol 2002;12:R233-5]. We report here that this effect is not common in yeast. Using different yeast strains, we demonstrate that identical treatment results in a low mortality even after prolonged treatment with the pheromone. These findings are followed by a general discussion of the biological relevance of apoptosis in yeast.
Zadrag
Renata
R
Department of Biochemistry and Cell Biology, University of Rzeszów, ul. Rejtana 16C, 35-959 Rzeszów, Poland.
Wojnar
Leszek
L
Bartosz
Grzegorz
G
Biliński
Tomasz
T
D017209:Apoptosis / Q000187:drug effects*; D000072235:Mating Factor; D010455:Peptides / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013997:Time Factors; D015003:Yeasts / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology
D010455:Peptides; D017382:Reactive Oxygen Species; D000072235:Mating Factor