title: Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population.
abstract: AKT1 (V-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of AKT. Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia. We tested for the presence of these five single-nucleotide polymorphisms in a Taiwanese population by genotyping 218 co-affected schizophrenia families. Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population.
authors.affiliation: Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Liu
authors.forename: Cathy Shen-Jang
authors.initials: CS
authors.lastname: Fann
authors.forename: Chih-Min
authors.initials: CM
authors.lastname: Liu
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.forename: Shuen-Iu
authors.initials: SI
authors.lastname: Hung
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Chan
authors.forename: Jiahn-Jyh
authors.initials: JJ
authors.lastname: Chen
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Pan
authors.forename: Shih-Kai
authors.initials: SK
authors.lastname: Liu
authors.forename: Ming H
authors.initials: MH
authors.lastname: Hsieh
authors.forename: Tzung-Jeng
authors.initials: TJ
authors.lastname: Hwang
authors.forename: Wen-Chen
authors.initials: WC
authors.lastname: Ouyang
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Chen
authors.forename: Jin-Jia
authors.initials: JJ
authors.lastname: Lin
authors.forename: Frank Huang-Chih
authors.initials: FH
authors.lastname: Chou
authors.forename: Ching-Mo
authors.initials: CM
authors.lastname: Chueh
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Liu
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Tsuang
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
mesh_terms: D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013624:Taiwan
chemical_list: D005819:Genetic Markers; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt