Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man.
BACKGROUND
It is unclear whether decreased serotonin transporter function contributes to sensorimotor abnormalities in irritable bowel syndrome.


OBJECTIVE
To study the influence of acute serotonin transporter inhibition on colonic sensorimotor function in man.


METHODS
Ten healthy subjects (five men, aged 20-29 years) underwent a combined manometry/barostat study of the descending colon on two occasions. Stepwise distentions by 2 mmHg increments were performed until discomfort. Subsequently, placebo or citalopram 20 mg were administered i.v. over 20 min and distentions were repeated. Afterwards, isobaric tone measurements were performed 30 min before and 90 min after ingestion of a meal. High-amplitude propagated contractions, colonic motility index, colonic compliance, sensitivity and colonic response to a meal after placebo or citalopram were compared by t-test and two-way ANOVA.


RESULTS
Citalopram induced a significant increase in colonic motility index (5.6 +/- 0.9 to 0.8 +/- 1.9 mL*min, P < 0.005) and high-amplitude propagated contractions (32 after citalopram vs. 2 after placebo, P < 0.05), which were associated with abdominal cramping. Administration of citalopram increased colonic compliance (10.3 +/- 1.5 vs. 14.5 +/- 2.2 mL/mmHg, P < 0.01) and inhibited colonic response to a meal (volume decrease 48 +/- 12 vs. 16 +/- 12 mL, P < 0.01).


CONCLUSIONS
Acute serotonin transporter inhibition in man increases colonic phasic contractility and the occurrence of high-amplitude propagated contractions, increases colonic compliance and suppresses the colonic tonic response to a meal. These data suggest that both release and elimination of 5-hydroxytryptamine by serotonin transporter are involved in the control of colonic motility in man.
Tack
J
J
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium. jan.tack@med.kuleuven.ac.be
Broekaert
D
D
Corsetti
M
M
Fischler
B
B
Janssens
J
J
D000328:Adult; D015283:Citalopram / Q000008:administration & dosage*; D003106:Colon / Q000187:drug effects / Q000502:physiology*; D004435:Eating / Q000502:physiology; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008365:Manometry / Q000379:methods; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*
D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors