Issues of aging and geriatric medicine: relevance to cancer treatment and hematopoietic reconstitution.
Aging is not a disease. Nevertheless, diseases, including most malignancies, increase in frequency with advancing age. Although there are many reasons why this might be the case, perhaps most important is that it takes time to progress through the many steps of carcinogenesis and growth to reach a threshold for diagnosis. Other factors, including accumulated nonlethal damage to DNA (eg, by free radicals), increased proinflammatory factors, and age-associated declines in DNA repair and immune competence, are to some degree important. The median age for all cancer is approximately 70 years and will become even older over the next several decades. Myelodysplasia and hematologic malignancies, including lymphoma, myeloma, and leukemia, can be effectively treated in older age groups, but advanced age presents a number of additional challenges. With appropriate pretreatment assessment of organ reserve, physical performance, and cognitive function, individualized (tailored) therapy may ultimately prove to offer the greatest chance for successful outcomes. Such assessment would also identify those who are likely to benefit from more aggressive treatments, including bone marrow or stem cell transplantation.
Ershler
William B
WB
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA. wershler@iasia.org
Artz
Andrew S
AS
Keller
Evan T
ET
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000379:methods / Q000401:mortality / Q000639:trends; D004249:DNA Damage; D018572:Disease-Free Survival; D005260:Female; D005853:Geriatrics / Q000379:methods / Q000639:trends; D019337:Hematologic Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006410:Hematopoiesis; D006801:Humans; D007249:Inflammation / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008297:Male; D020127:Recovery of Function; D012074:Remission Induction / Q000379:methods; D016896:Treatment Outcome