title: Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives.
abstract: Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type 1 or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10(-3)). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10(-4)). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.
authors.affiliation: Laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté Necker, Université de Paris René Descartes INSERM U550, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Besson
authors.forename: Corinne
authors.initials: C
authors.lastname: Amiel
authors.forename: Catherine
authors.initials: C
authors.lastname: Le-Pendeven
authors.forename: Pauline
authors.initials: P
authors.lastname: Brice
authors.forename: Christophe
authors.initials: C
authors.lastname: Fermé
authors.forename: Patrice
authors.initials: P
authors.lastname: Carde
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Martine
authors.initials: M
authors.lastname: Raphael
authors.forename: Laurent
authors.initials: L
authors.lastname: Abel
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Nicolas
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000276:immunology; D036022:Capsid Proteins / Q000276:immunology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology / Q000821:virology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008223:Lymphoma / Q000145:classification / Q000276:immunology / Q000821:virology*; D008297:Male; D014412:Tumor Virus Infections / Q000276:immunology*; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D007074:Immunoglobulin G