title: No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population.
abstract: OBJECTIVE
  A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.
  
  
  METHODS
  We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).
  
  
  RESULTS
  We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.
  
  
  CONCLUSIONS
  The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.
authors.affiliation: Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen & Rigshospitalet University Hospital, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Lindberg
authors.forename: P
authors.initials: P
authors.lastname: Koefoed
authors.forename: E S
authors.initials: ES
authors.lastname: Hansen
authors.forename: T G
authors.initials: TG
authors.lastname: Bolwig
authors.forename: J F
authors.initials: JF
authors.lastname: Rehfeld
authors.forename: E
authors.initials: E
authors.lastname: Mellerup
authors.forename: O S
authors.initials: OS
authors.lastname: Jørgensen
authors.forename: L V
authors.initials: LV
authors.lastname: Kessing
authors.forename: T
authors.initials: T
authors.lastname: Werge
authors.forename: S
authors.initials: S
authors.lastname: Haugbøl
authors.forename: A G
authors.initials: AG
authors.lastname: Wang
authors.forename: D P D
authors.initials: DP
authors.lastname: Woldbye
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D017931:DNA Primers / Q000235:genetics; D003718:Denmark / Q000453:epidemiology; D003866:Depressive Disorder / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D016584:Panic Disorder / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D012559:Schizophrenia / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*
chemical_list: D017931:DNA Primers; D009478:Neuropeptide Y