[Treatment resistant schizophrenia, residual subtype: symptom improvement after additional treatment with amisulpride].
BACKGROUND
Therapy resistant, severe residual schizophrenia poses major challenges for the psychiatric pharmacological treatment.


METHODS
We report about a 44-year old schizophrenic male who has been detained in a closed forensic ward for 10 years, following a conviction in one manslaughter case. Despite various pharmacological treatment efforts severe residual schizophrenia remained.


RESULTS
Adding Amisulpride to the ongoing treatment with Olanzapine achieved a noticeable improvement of symptoms, resulting in the possibility of relaxing imprisonment conditions.


CONCLUSIONS
A combination of Amisulpride and Olanzapine seems to be effective in treating severe residual schizophrenia.
Wolf
Karsten
K
Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Psychiatrie und Psychotherapie. k.wolf@uke.uni-hamburg.de
Veismann
Stefan
S
Knecht
Guntram
G
Naber
Dieter
D
D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects; D003134:Commitment of Persons with Psychiatric Disorders / Q000331:legislation & jurisprudence; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006708:Homicide / Q000331:legislation & jurisprudence* / Q000523:psychology; D006801:Humans; D007298:Insanity Defense; D008297:Male; D000077152:Olanzapine; D011329:Prisoners / Q000523:psychology*; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D013469:Sulpiride / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D013469:Sulpiride; D000077582:Amisulpride; D003024:Clozapine; D006220:Haloperidol; D000077152:Olanzapine