title: Antiepileptic drug trials in the elderly.
abstract: It is important to perform clinical trials of antiepileptic drugs (AEDs) in elderly because they differ in many ways from younger people. The response of elderly people to AEDs may not be predictable from studies focused exclusively on younger adults. Major issues of concern include altered absorption and metabolism, as well as the likelihood of interactions with concomitant medications.
authors.forename: I
authors.initials: I
authors.lastname: Leppik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000927:Anticonvulsants / Q000378:metabolism / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods; D004347:Drug Interactions; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans
chemical_list: D000927:Anticonvulsants