title: Investigation and characterization of liquid two-phase systems for the separation of crystal mixtures by interfacial partitioning.
abstract: The interfacial partitioning behavior of ampicillin and phenylglycine crystals in different two-phase systems has been investigated. The two-phase systems employed are water/dodecane, water/1-butanol, and water/pentane/methanol. By means of partition experiments and microscopic imaging, it has been shown that the mechanism of separation strongly depends on the choice of the two-phase system. While water/dodecane features a mechanism of sheer competitive adsorption at the interface, separation in water/1-butanol is mainly due to partitioning into both liquid phases, leading to a higher degree of separation. Experiments with water/pentane/methanol have illustrated the large potential of three-component systems, as slight variations in the composition can have large effects on the separation.
authors.affiliation: Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands.
authors.forename: Martijn A
authors.initials: MA
authors.lastname: Hoeben
authors.forename: Pim
authors.initials: P
authors.lastname: van Hee
authors.forename: Rob G J M
authors.initials: RG
authors.lastname: van der Lans
authors.forename: Gerard
authors.initials: G
authors.lastname: Kwant
authors.forename: Luuk A M
authors.initials: LA
authors.lastname: van der Wielen
mesh_terms: D020001:1-Butanol / Q000737:chemistry; D000327:Adsorption; D000473:Alkanes / Q000737:chemistry; D000667:Ampicillin / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D005427:Flocculation; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D010420:Pentanes / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000473:Alkanes; D010420:Pentanes; D014867:Water; C007548:n-dodecane; C033353:pentane; C008852:2-phenylglycine; D000667:Ampicillin; D020001:1-Butanol; D005998:Glycine; D000432:Methanol