Effect of statin on restenosis after radius stent implantation in patients with acute coronary syndrome.
Despite reports that statin treatment reduces the rate of coronary restenosis with a balloon expandable stent, there is no evidence that statins affect the incidence of restenosis with a self-expanding Radius stent. Ninety-five patients with acute coronary syndrome who had been implanted with a Radius stent were classified into two groups: those with hyperlipidemia and initial statin treatment (statin group, n = 38) and those without statin treatment (comparative group, n = 57). At six months after stent implantation, the rate of coronary restenosis was significantly lower in the statin group (10.5%) than control group (28.1%) (p = 0.033), while there were no differences in morphology, maximal inflation pressure or stent size between the two groups. Interestingly, there was no difference in the serum lipid profile between the two groups at the 6-month follow-up, although the statin group had a significantly lower rate of restenosis. In conclusion, initial statin therapy reduced the rate of coronary restenosis even when a Radius stent was implanted.
Nishikawa
Hiroaki
H
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Miura
Shin-Ichiro
S
Shimomura
Hideki
H
Kawamura
Akira
A
Tsujita
Kenichi
K
Shirai
Kazuyuki
K
Matsuo
Kunihiro
K
Arai
Hidekazu
H
Saku
Keijiro
K
D000208:Acute Disease; D000368:Aged; D003131:Combined Modality Therapy; D003251:Constriction, Pathologic / Q000517:prevention & control*; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015607:Stents
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors