Currently used antimycotics: spectrum, mode of action and resistance occurrence.
The increasing incidence of fungal infections combined with the emerging problem of antifungal drug resistance have prompted investigations of the mode of action of the currently used antifungal therapeutics (antimycotics). The routinely used antimycotics can be grouped into six different classes based on their mode of action. In this review, the mode of action and antifungal spectrum of these classes are discussed, together with possible resistance development against them.
Francois
Isabelle E J A
IE
Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, B-3001 Heverlee, Belgium. isabelle.francois@biw.kuleuven.be
Aerts
An M
AM
Cammue
Bruno P A
BP
Thevissen
Karin
K
D000499:Allylamine / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001393:Azoles / Q000737:chemistry / Q000494:pharmacology; D025141:Drug Resistance, Fungal; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D011090:Polyenes / Q000737:chemistry / Q000494:pharmacology; D013859:Thiocarbamates / Q000737:chemistry / Q000494:pharmacology
D000935:Antifungal Agents; D001393:Azoles; D011090:Polyenes; D013859:Thiocarbamates; D000499:Allylamine