title: Toxicity and biodegradability assessment of raw and ozonated procaine penicillin G formulation effluent.
abstract: The effect of O3 (applied dose = 1440 mg h(-1); pH 7 and pH 12) and H2O2/O3 (applied dose = 1440 mg h(-1); pH 7; 10 mM H2O2) pretreatment of procaine penicillin G (PPG) formulation effluent on its biodegradability and acute toxicity was investigated. For that purpose ISO 8192 activated sludge inhibition and Daphnia magna acute toxicity tests were conducted. BOD5 measurements that were carried out to preevaluate the biocompatibility of untreated, ozonated, and perozonated PPG effluent have shown that BOD5 alone was not a very correct or useful tool to predict the actual biodegradability of PPG effluent. No significant correlation existed between the BOD5 and the toxicity test results. Acute toxicity studies carried out with D. magna and synthetic municipal sewage sludge have demonstrated the inhibitory effect of H2O2/O3 oxidation. COD removal of pharmaceutical wastewater containing PPG effluent with acclimated sewage sludge decreased from 79% to 50% after H2O2/O3 pretreatment.
authors.affiliation: Department of Environmental Engineering, Faculty of Civil Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey. arslanid@itu.edu.tr
authors.forename: Idil
authors.initials: I
authors.lastname: Arslan-Alaton
authors.forename: Ali Efe
authors.initials: AE
authors.lastname: Caglayan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D001673:Biodegradation, Environmental; D019149:Bioreactors; D003621:Daphnia / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000737:chemistry; D007220:Industrial Waste / Q000009:adverse effects*; D016877:Oxidants / Q000737:chemistry*; D010100:Oxygen / Q000378:metabolism; D010126:Ozone / Q000737:chemistry; D010402:Penicillin G Procaine; D012722:Sewage / Q000382:microbiology; D018675:Toxicity Tests; D014865:Waste Disposal, Fluid
chemical_list: D000900:Anti-Bacterial Agents; D007220:Industrial Waste; D016877:Oxidants; D012722:Sewage; D010402:Penicillin G Procaine; D010126:Ozone; D006861:Hydrogen Peroxide; D010100:Oxygen