title: Nasobiliary drainage induces long-lasting remission in benign recurrent intrahepatic cholestasis.
abstract: Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. Effective medical treatment is not available. We report complete and long-lasting disappearance of pruritus and normalization of serum bile salt concentrations in cholestatic BRIC patients within 24 hours after endoscopic nasobiliary drainage (NBD). Relative amounts of phospholipids and bile salts in bile collected during NBD appeared to be normal, but phospholipids other than phosphatidylcholine (especially sphingomyelin) were increased. In conclusion, we propose that temporary endoscopic nasobiliary drainage should be considered in cholestatic BRIC patients.
authors.affiliation: Department of Pediatric Gastroenterology, University Medical Center Utrecht, The Netherlands.
authors.forename: Janneke M
authors.initials: JM
authors.lastname: Stapelbroek
authors.forename: Karel J
authors.initials: KJ
authors.lastname: van Erpecum
authors.forename: Leo W J
authors.initials: LW
authors.lastname: Klomp
authors.forename: Niels G
authors.initials: NG
authors.lastname: Venneman
authors.forename: Thijs P
authors.initials: TP
authors.lastname: Schwartz
authors.forename: Gerard P
authors.initials: GP
authors.lastname: van Berge Henegouwen
authors.forename: John
authors.initials: J
authors.lastname: Devlin
authors.forename: Carin M J
authors.initials: CM
authors.lastname: van Nieuwkerk
authors.forename: A S
authors.initials: AS
authors.lastname: Knisely
authors.forename: Roderick H J
authors.initials: RH
authors.lastname: Houwen
mesh_terms: D000328:Adult; D001646:Bile / Q000737:chemistry; D001647:Bile Acids and Salts / Q000032:analysis; D002780:Cholestasis, Intrahepatic / Q000628:therapy*; D004322:Drainage / Q000379:methods*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009666:Nose; D010743:Phospholipids / Q000032:analysis; D012008:Recurrence
chemical_list: D001647:Bile Acids and Salts; D010743:Phospholipids