title: Multilocular cystic renal cell carcinoma : a report of 45 cases of a kidney tumor of low malignant potential.
abstract: The 2004 World Health Organization (WHO) classification of kidney tumors recognizes multilocular cystic renal cell carcinoma (MCRCC) as a rare variant of clear cell renal cell carcinoma with a good prognosis. Available information on its clinical significance is limited. The study cohort included 45 MCRCC cases classified according to 2004 WHO criteria obtained through a multi-institutional international search. Most patients had unilateral MCRCC with no side predominance that was found incidentally; 62% were men, but women had tumors at an earlier age (P = .385). MCRCC occurred slightly more often in men than in women (1.7:1). At diagnosis, 82% of patients had stage T1 and 16%, stage T2; 1 patient had stage T3. The Fuhrman grade was 1 (62%) or 2 (38%), with smaller tumors (<or=4 cm) most likely Fuhrman grade 1 (P = .911). All 45 patients were alive with no evidence of disease at mean follow-up of 66.1 months, confirming an extremely good prognosis after surgery and a 5-year disease-specific survival rate of 100%. To rename this tumor as multilocular cystic renal cell neoplasm of low malignant potential might help urologists approach the patients conservatively.
authors.affiliation: Laborclin Laboratory, São José do Rio Prêto, Brazil.
authors.forename: Sueli
authors.initials: S
authors.lastname: Suzigan
authors.forename: Antonio
authors.initials: A
authors.lastname: López-Beltrán
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.forename: Ricardo
authors.initials: R
authors.lastname: Drut
authors.forename: Ana
authors.initials: A
authors.lastname: Romero
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Ana L C
authors.initials: AL
authors.lastname: Gentili
authors.forename: Paulo S P
authors.initials: PS
authors.lastname: Fonseca
authors.forename: Ines
authors.initials: I
authors.lastname: deTorres
authors.forename: Athanase
authors.initials: A
authors.lastname: Billis
authors.forename: Lucia C
authors.initials: LC
authors.lastname: Japp
authors.forename: Enrico
authors.initials: E
authors.lastname: Bollito
authors.forename: Ferran
authors.initials: F
authors.lastname: Algaba
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Requena-Tapias
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged