Regression models for hazard rates versus cumulative incidence probabilities in hematopoietic cell transplantation data.
In this article, we consider methods of regression modeling in the competing risks setting commonly encountered in analyzing stem cell transplantation data. We clarify the distinction between modeling the cause-specific hazard rate and modeling the cumulative incidence probability or function, and we review regression techniques for both types of quantities. We apply them to 2 examples: 1 comparing engraftment and 1 examining relapse. These examples illustrate that different conclusions may result depending on the type of regression model used for comparing treatments. Finally, we show how these discrepancies occur because 2 different characteristics of the time-to-event distribution are being modeled.
Logan
Brent R
BR
Division of Biostatistics and Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, USA.
Zhang
Mei-Jie
MJ
Klein
John P
JP
D006084:Graft Rejection; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D012008:Recurrence; D012044:Regression Analysis; D012307:Risk Factors; D013997:Time Factors