A new variant of the mouse Akp1 locus.
A new electrophoretic migration type of alkaline phosphatase 1 (Akp1) was found on the cellulose acetate electrophoresis for kidney and liver homogenates of KWHM mouse, a newly established inbred strain derived from the Korean wild mouse (Mus musculus molossinus). This new type of alkaline phosphatase 1 was distinguished from previously reported AKP1A and AKP1B types in the mouse, and tentatively named AKP1C. In genetic analysis by mating experiments between KWHM and C57BL/6J (AKP1A) or BALB/cA (AKP1B), the phenotypic segregation ratios of AKP1A : AKP1AC : AKP1C or AKP1B : AKP1BC : AKP1C were 1 : 2 : 1 in both groups of F2 generations. It was therefore concluded that AKP1C type is controlled by Akp1c allele which is codominant with Akp1a and Akp1b alleles.
Lee
Chul-Ho
CH
ICLAS Monitoring Subcenter Korea, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, Korea.
Kim
Eun-Hee
EH
Won
Young-Suk
YS
Choi
Yang-Kyu
YK
Nam
Ki-Hoan
KH
Kim
Hyoung-Chin
HC
Hyun
Byung-Hwa
BH
Suh
Jun-Gyo
JG
Oh
Yang-Seok
YS
D000469:Alkaline Phosphatase / Q000235:genetics* / Q000378:metabolism; D000483:Alleles; D000818:Animals; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D014644:Genetic Variation; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice / Q000235:genetics*; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains
D000469:Alkaline Phosphatase