title: A highly selective synthesis of 3-hydroxy-2-methylpropionamide involving a one-pot tandem hydroformylation-hydrogenation sequence.
abstract: 3-Hydroxy-2-methylpropionamide, an important intermediate in the synthesis of methyl methacrylate, has been obtained with excellent conversion and high selectivity from acrylamide by a tandem hydroformylation-hydrogenation sequence catalysed by Rh/PPh3 and Raney Ni, respectively.
authors.affiliation: Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, Campus Sescelades, Tarragona, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: García
authors.forename: Carmen
authors.initials: C
authors.lastname: Claver
authors.forename: Montserrat
authors.initials: M
authors.lastname: Diéguez
authors.forename: Anna M
authors.initials: AM
authors.lastname: Masdeu-Bultó
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013696:Temperature
chemical_list: C518388:3-hydroxy-2-methylpropionamide; D000178:Acrylamides; D008024:Ligands; D009942:Organometallic Compounds; D020106:Acrylamide; D009532:Nickel; D012238:Rhodium