title: [Proton spectroscopy in Alzheimer's disease and cognitive impairment not dementia: a community study].
abstract: OBJECTIVE
  To describe the proton magnetic resonance spectroscopy (1H-ERM) data in Alzheimer's disease (AD) and Cognitive Impairment Not Dementia (CIND) in a community sample.
  
  
  METHODS
  We investigated subjects with AD (n=6), CIND (n=7) and normal control (n=7). 1H-ERM was performed with single voxel (8 cm3) placed in temporal, parietal and occipital regions and studied metabolites were: N-acetylaspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mI).
  
  
  RESULTS
  NAA concentration was higher in control subjects than AD and intermediated in CIND patients. Cho parietal plus occipital and Cr parietal plus Cho occipital classified correctly 92.3% of subjects Control vs AD. Temporal mI classified 78.6% of subjects between Control vs CIND.
  
  
  CONCLUSIONS
  Spectroscopy can be used in the diagnosis and follow-up of individuals with cognitive impairment; evaluation of community subjects may show different patterns of brain metabolites distribution.
authors.affiliation: Projeto Terceira Idade (PROTER), Instituto e Departamento de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil. dionosioazevedo@uol.com.br
authors.forename: Dionísio
authors.initials: D
authors.lastname: Azevedo
authors.forename: Cássio M C
authors.initials: CM
authors.lastname: Bottino
authors.forename: Mariana
authors.initials: M
authors.lastname: Tatsch
authors.forename: Sergio R
authors.initials: SR
authors.lastname: Hototian
authors.forename: Mario C
authors.initials: MC
authors.lastname: Bazzarella
authors.forename: Cláudio C
authors.initials: CC
authors.lastname: Castro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D016022:Case-Control Studies; D002794:Choline / Q000032:analysis / Q000378:metabolism; D003072:Cognition Disorders / Q000378:metabolism*; D003401:Creatine / Q000032:analysis / Q000378:metabolism; D004522:Educational Status; D005260:Female; D006801:Humans; D007294:Inositol / Q000032:analysis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009483:Neuropsychological Tests; D011522:Protons
chemical_list: D011522:Protons; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline