[The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients].
Large multifunctional protease LMP2 (Arg60-->His) and LMP7 (Lys145-->Gln) gene allelic polymorphism in 200 patients with acute coronary syndrome and in 80 practically healthy people was determinated. It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; P > 0.05 by chi2-test). Analysis of LMP7 gene polymorphism has shown that Lys/Lys - 89.5 %, Lys/Gln - 10.5 %, Gin/Gin - 0 % (in control group 93.8, 6.2, 0 % correspondingly; P > 0.05). The data show that LMP2 and LMP7 gene polymorphism is not a risk factor of acute coronary syndrome in Ukrainian population.
Dosenko
V E
VE
Mikhal'chuk
D
D
Zagoriĭ
V Iu
VIu
Parkhomenko
A N
AN
Moĭbenko
A A
AA
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D020134:Catalytic Domain; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000235:genetics*
D046988:Proteasome Endopeptidase Complex