Adult-onset nemaline myopathy and monoclonal gammopathy.
A 45-year-old man with severe proximal muscle weakness had findings diagnostic of adult-onset nemaline myopathy. He also had a monoclonal gammopathy. This is the fifth report of adult-onset nemaline myopathy in a patient with monoclonal gammopathy, suggesting that the occurrence of these entities may be more than a chance association. Myocyte-bound immunoglobulin or light chains were not detected and immunotherapy was not effective in this patient. Other causes of adult-onset nemaline myopathy were ruled out, including the most common mutations of sarcomeric thin filament genes.
Keller
Christian E
CE
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. chk9021@nyp.org
Hays
Arthur P
AP
Rowland
Lewis P
LP
Moghadaszadeh
Behzad
B
Beggs
Alan H
AH
Bhagat
Govind
G
D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008875:Middle Aged; D017696:Myopathies, Nemaline / Q000150:complications* / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications* / Q000473:pathology