Synthesis of various glycopolymer architectures via RAFT polymerization: from block copolymers to stars.
Well-defined linear poly(acryloyl glucosamine) (PAGA) exhibiting molar masses ranging from 3 to 120 K and low polydispersities have been prepared via reversible addition-fragmentation chain transfer polymerization (RAFT) in aqueous solution without recourse to protecting group chemistry. The livingness of the process was further demonstrated by successfully chain-extending one of these polymers with N-isopropylacrylamide affording narrow dispersed thermosensitive diblocks. This strategy of polymerization was finally extended to the preparation of glycopolymer stars from Z designed non-water-soluble trifunctional RAFT agent. After the growth of very short blocks of poly(hydroxyethyl acrylate) ((-)DP(n)(branch) = 10), AGA was polymerized in aqueous solution in a controlled manner affording well-defined 3-arm glycopolymer stars.
Bernard
Julien
J
Centre for Advanced Macromolecular Design (CAMD), School of Engineering and Industrial Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
Hao
Xiaojuan
X
Davis
Thomas P
TP
Barner-Kowollik
Christopher
C
Stenzel
Martina H
MH
D000178:Acrylamides / Q000737:chemistry; D006031:Glycosylation; D015394:Molecular Structure; D008970:Molecular Weight; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature
D000178:Acrylamides; D011108:Polymers; C067295:N-isopropylacrylamide