Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice.
Myelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with Euphorbia tirucalli L. (ET) (125, 250 and 500 mg/kg) stimulated marrow myelopoiesis and reduced spleen colony formation, with no differences observed between the effects of the three doses. The changes produced by the tumour in total and differential marrow cell counts were restored by the treatment with ET. Prostaglandin E2 (PGE2) levels, which were dramatically increased in tumour bearers, was also abrogated by the treatment with the plant extract. Euphorbia tirucalli L. significantly enhanced survival and concurrently reduced tumour growth in the peritoneal cavity. We propose that the modulatory effect of Euphorbia tirucalli L. on myelopoietic response and on the levels of PGE2 may be related to its antitumour activity as a possible mechanism for the regulation of granulocyte and macrophage production and expression of functional activities.
Valadares
Marize C
MC
Departamento de Farmacologia/Hemocentro, Faculdade de Ciências Médicas, FCM, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil.
Carrucha
Silvia Granja
SG
Accorsi
Walter
W
Queiroz
Mary L S
ML
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D015232:Dinoprostone / Q000096:biosynthesis; D028481:Euphorbia / Q000737:chemistry*; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D038042:Myelopoiesis / Q000187:drug effects*; D014411:Neoplastic Stem Cells; D010936:Plant Extracts / Q000494:pharmacology; D013154:Spleen / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D016019:Survival Analysis
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D015232:Dinoprostone