title: Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics.
abstract: The histologic distinction between meningiomas and other tumors of the central nervous system occasionally can be difficult. Claudin-1 is a tight junction-associated protein recently shown to be expressed in anaplastic meningiomas. The purpose of this study was to determine whether immunohistochemical staining for claudin-1 could help distinguish meningiomas from histologic mimics, compared with commonly used markers. Tissue sections from 10 meningothelial meningiomas, 20 fibrous meningiomas, 10 atypical meningiomas, 7 solitary fibrous tumors of the meninges, 5 meningeal hemangiopericytomas, and 7 vestibular schwannomas were stained immunohistochemically for claudin-1, epithelial membrane antigen, S-100 protein, CD34, and glial fibrillary acidic protein. In total, 21 (53%) of 40 meningiomas were immunoreactive for claudin-1, whereas none of the other tumors were positive. In contrast, there was considerable overlap in the distribution of the other antibodies evaluated. Claudin-1 seems to be a specific marker for meningiomas in this context. Although its sensitivity is relatively low, claudin-1 may be helpful in a panel of immunostains to distinguish meningiomas from histologic mimics.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Hejin P
authors.initials: HP
authors.lastname: Hahn
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Bundock
authors.forename: Jason L
authors.initials: JL
authors.lastname: Hornick
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D062445:Claudin-1; D003937:Diagnosis, Differential; D006393:Hemangiopericytoma / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000032:analysis*; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000473:pathology*; D008579:Meningioma / Q000737:chemistry / Q000473:pathology*; D018396:Mucin-1 / Q000032:analysis; D013194:Staining and Labeling
chemical_list: D018952:Antigens, CD34; C568108:CLDN1 protein, human; D062445:Claudin-1; D008565:Membrane Proteins; D018396:Mucin-1