title: Intravenous immunoglobulin and dendritic cells.
abstract: Intravenous immunoglobulin (IVIg) has increasingly been used for the treatment of autoimmune and systemic inflammatory diseases, and in supportive therapy of immunodeficient patients. Available clinical and experimental evidence suggests, however, that a wide spectrum of immune-mediated conditions could benefit from IVIg, including acute and chronic/relapsing diseases and autoimmune diseases mediated by pathogenic autoantibodies or by autoaggressive T-cells. Dendritic cells (DCs) are professional antigen-presenting cells and because of their capacity to stimulate naïve T-cells, they play a central role in the initiation of primary immune responses. Several immunomodulatory agents have been shown to inhibit DC activation. Recently, we examined the effects of IVIg on differentiation, maturation, and functions of DCs. We demonstrate that DCs are one of the targets for the immunomodulatory effects of IVIg.
authors.affiliation: Inserm, U681, Paris, France.
authors.forename: Namita
authors.initials: N
authors.lastname: Misra
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayary
authors.forename: Sooryasarathi
authors.initials: S
authors.lastname: Dasgupta
authors.forename: Amal
authors.initials: A
authors.lastname: Ephrem
authors.forename: Jean-Paul Duong Van
authors.initials: JP
authors.lastname: Huyen
authors.forename: Sandrine
authors.initials: S
authors.lastname: Delignat
authors.forename: Gazzala
authors.initials: G
authors.lastname: Hassan
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Caligiuri
authors.forename: Antonino
authors.initials: A
authors.lastname: Nicoletti
authors.forename: Sebastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
authors.forename: Michel D
authors.initials: MD
authors.lastname: Kazatchkine
authors.forename: Srini V
authors.initials: SV
authors.lastname: Kaveri
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects / Q000276:immunology; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000276:immunology* / Q000494:pharmacology*
chemical_list: D016756:Immunoglobulins, Intravenous