title: Hypoglycaemic activity of Pterocarpus marsupium Roxb.
abstract: The antidiabetic activity of various subfractions of the alcohol extract of the bark of Pterocarpus marsupium Roxb. was evaluated in alloxan-induced diabetic rats. The effect of these extracts on lipid profile and liver function tests were also assessed to evaluate their activity in controlling diabetes related metabolic alterations. The parameters measured were plasma glucose, total protein, cholesterol, triglycerides, alkaline phosphatase, SGOT and SGPT. The results indicate the effective role of Pterocarpus marsupium on the above mentioned parameters indicating that Pterocarpus marsupium can also control the diabetes related metabolic alterations apart from controlling the glucose levels. Among the fractions tested the butanol subfraction was found to be more active in comparison with other subfractions. It can be concluded that the butanol subfraction of the alcohol extract of Pterocarpus marsupium exhibits significant antidiabetic activity and corrects the metabolic alterations in diabetic rats and this activity may resemble insulin-like properties.
authors.affiliation: Department of Pharmacognosy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India. dhanskanaksahil@rediffmail.com
authors.forename: S P
authors.initials: SP
authors.lastname: Dhanabal
authors.forename: C K
authors.initials: CK
authors.lastname: Kokate
authors.forename: M
authors.initials: M
authors.lastname: Ramanathan
authors.forename: E P
authors.initials: EP
authors.lastname: Kumar
authors.forename: B
authors.initials: B
authors.lastname: Suresh
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001798:Blood Proteins / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008111:Liver Function Tests; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D035721:Pterocarpus; D051381:Rats; D012997:Solvents
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D012997:Solvents