title: SMART 5: domains in the context of genomes and networks.
abstract: The Simple Modular Architecture Research Tool (SMART) is an online resource (http://smart.embl.de/) used for protein domain identification and the analysis of protein domain architectures. Many new features were implemented to make SMART more accessible to scientists from different fields. The new 'Genomic' mode in SMART makes it easy to analyze domain architectures in completely sequenced genomes. Domain annotation has been updated with a detailed taxonomic breakdown and a prediction of the catalytic activity for 50 SMART domains is now available, based on the presence of essential amino acids. Furthermore, intrinsically disordered protein regions can be identified and displayed. The network context is now displayed in the results page for more than 350 000 proteins, enabling easy analyses of domain interactions.
authors.affiliation: EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany.
authors.forename: Ivica
authors.initials: I
authors.lastname: Letunic
authors.forename: Richard R
authors.initials: RR
authors.lastname: Copley
authors.forename: Birgit
authors.initials: B
authors.lastname: Pils
authors.forename: Stefan
authors.initials: S
authors.lastname: Pinkert
authors.forename: Jörg
authors.initials: J
authors.lastname: Schultz
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
mesh_terms: D002384:Catalysis; D020134:Catalytic Domain; D030562:Databases, Protein; D023281:Genomics; D020407:Internet; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D014584:User-Computer Interface
chemical_list: D046912:Multiprotein Complexes