title: A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
abstract: Dandruff is a chronic condition of the scalp requiring vigilant treatment to ameliorate the symptoms of scaling and itching. Frequent shampooing is key to controlling these symptoms while contributing to the cosmetic appearance of the hair. The success of the treatment depends not only on the ability of the shampoo to control the dandruff but also on patient compliance engendered by the cosmetic attributes of the shampoo. This double-blind cross-over study enrolled 40 women with mild to moderate dandruff. Following a 1-wk washout with an unmedicated basic cleansing shampoo, all subjects used each of the two study shampoos for 1 wk. Subjects preferred the 1% pyrithione zinc conditioning shampoo over the 2% ketoconazole shampoo by 75% in terms of overall performance. The dermatologist investigator confirmed the subject preference by noting that hair-combing ease, hair smoothness, and hair frizz/flyaway were statistically significantly better in subjects who used the 1% pyrithione zinc conditioning shampoo for 1 wk. This study suggests that hair condition is an important consideration in the treatment of dandruff due to compliance.
authors.affiliation: Department of Dematology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. zdraelos@northstate.net
authors.forename: Zoe Diana
authors.initials: ZD
authors.lastname: Draelos
authors.forename: Dianna Chute
authors.initials: DC
authors.lastname: Kenneally
authors.forename: Lauren Thaman
authors.initials: LT
authors.lastname: Hodges
authors.forename: Ward
authors.initials: W
authors.lastname: Billhimer
authors.forename: Megan
authors.initials: M
authors.lastname: Copas
authors.forename: Carl
authors.initials: C
authors.lastname: Margraf
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D018592:Cross-Over Studies; D012628:Dermatitis, Seborrheic / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004890:Erythema / Q000209:etiology; D005260:Female; D006197:Hair / Q000187:drug effects*; D006203:Hair Preparations / Q000494:pharmacology*; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D010349:Patient Compliance; D017060:Patient Satisfaction; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use; D012535:Scalp / Q000503:physiopathology; D013871:Thiones
chemical_list: D000935:Antifungal Agents; D006203:Hair Preparations; D011725:Pyridines; D013871:Thiones; C008704:pyrithione; D007654:Ketoconazole