Total synthesis of ecteinascidin 743.
A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.
Chen
Jinchun
J
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
Chen
Xiaochuan
X
Bois-Choussy
Michèle
M
Zhu
Jieping
J
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis; D004149:Dioxoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin; D014561:Urochordata / Q000737:chemistry
D018906:Antineoplastic Agents, Alkylating; D004149:Dioxoles; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin