Study of energy metabolism of skeletal muscles in alcoholic liver disease--expired gas analysis during exercise.
BACKGROUND
The effects of chronic alcohol intake on skeletal muscle are clinically observed as muscle cramps with decrease in the amount of muscle. It was clarified by expired gas analysis that acute alcohol load affects disturbed energy metabolism of skeletal muscle. We studied abnormal energy metabolism of skeletal muscles in alcoholic liver diseases using expired gas analysis.


METHODS
Subjects of the study were five inpatients with alcoholic liver disease (fatty liver: one case, hepatic fibrosis: one case, liver cirrhosis: three case). Expired gas analysis during exercise was performed using AEROMONITOR. Minute ventilation, oxygen consumption and carbon dioxide output were monitored, and anaerobic threshold (AT) and respiratory compensation point (RCP) were calculated.


RESULTS
The anaerobic threshold, which is the limit of the aerobic exercise, was significantly reduced in patients with alcoholic disease (p < 0.01). The respiratory compensation point, which is the limit of the metabolic compensation of intracellular lactic acidosis, was decreased (p < 0.01).


CONCLUSIONS
The results of expired gas analysis during exercise indicate that the aerobic energy metabolism of skeletal muscle had been disturbed in alcoholic liver disease. The reduced RCP suggests that the lactate metabolism in skeletal muscle is also disturbed in alcoholic liver disease. Expired gas analysis during exercise allows determination of the amount of exercise required to treat liver diseases through analysis of AT.
Shiraishi
Koichi
K
Department of Gastroenterology, Tokai University, Hachioji Hospital, Tokyo, Japan.
Motegi
Shigeyuki
S
Nagaoka
Reiko
R
Ogasawara
Fusao
F
Saito
Tetsuro
T
Watanabe
Mitsuyuki
M
Matsuzaki
Shohei
S
D000328:Adult; D000332:Aerobiosis / Q000502:physiology; D015308:Anaerobic Threshold; D048909:Diabetes Complications / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005740:Gases / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*
D005740:Gases; D019344:Lactic Acid