Squinting at the zebrafish axis.
The Nodal family of signaling molecules includes critical intercellular regulators of early vertebrate development. In a recent issue of Nature, maternal transcripts encoding the zebrafish nodal squint were shown to be localized to the future organizer region by the four-cell stage, providing the earliest evidence of embryonic axis asymmetry in the zebrafish embryo.
Kimelman
David
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Department of Biochemistry, Box 357350, University of Washington, Seattle, Washington 98195, USA.
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D004625:Embryo, Nonmammalian; D004707:Endoderm; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D055456:Nodal Signaling Ligands; D015398:Signal Transduction / Q000502:physiology*; D015027:Zebrafish / Q000502:physiology*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
D055456:Nodal Signaling Ligands; D029961:Zebrafish Proteins; C485171:ndr1 protein, zebrafish