title: Management of opioid-induced sedation in patients with cancer.
abstract: Opioid-induced sedation is a common dose-limiting side effect of opioid therapy that can be very distressing and sometimes is more difficult to manage than pain. Opioid-induced sedation may prohibit patients from participating in certain activities of daily living, which can be a source of considerable distress for patients and their families. The issue presents a therapeutic dilemma for healthcare professionals caring for patients experiencing the side effect. Currently, several therapeutic approaches are used to counteract or minimize the severity of opioid-induced sedation, including reduction of the opioid dose, the addition of other drugs, opioid rotation, and the use of invasive routes of administration. This article will address the management of opioid-induced sedation.
authors.affiliation: Yale-New Haven Hospital, CT, USA. lbourdeanu@yahoo.com
authors.forename: Laura
authors.initials: L
authors.lastname: Bourdeanu
authors.forename: Diane B
authors.initials: DB
authors.lastname: Loseth
authors.forename: Marjorie
authors.initials: M
authors.lastname: Funk
mesh_terms: D000203:Activities of Daily Living; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D009369:Neoplasms / Q000451:nursing / Q000503:physiopathology*
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives