Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria.
Quorum sensing (QS) systems comprise a new therapeutic target potentially substitutive or complementary to traditional antibiotic treatment of chronic diseases. One route to disrupt the previously established interrelationship between pathogenesis and QS is by blocking the dual functioning signal/receptor transcriptional regulator in some clinically relevant Gram-negative bacteria. The present review contains all reported compound types that are currently known to inhibit the QS transcriptional regulator in Gram-negative bacteria. These compounds are sub-divided into two main groups, one comprising structural analogs of the native signaling molecules and the other compounds lacking structural resemblance. Biological activity is rationalized on the basis of structure-activity relationships and structural insight into the target protein.
Persson
Tobias
T
Department of Natural Sciences, Bioorganic Chemistry Section, The Royal Danish Veterinary and Agricultural University, DK-1871 Frederiksberg C, Denmark.
Givskov
Michael
M
Nielsen
John
J
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D002450:Cell Communication / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000166:cytology / Q000472:pathogenicity / Q000502:physiology*; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000037:antagonists & inhibitors*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D014157:Transcription Factors