Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese apricot.
A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml.
Miyazawa
Mitsuo
M
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University. miyazawa@apch.kindai.ac.jp
Utsunomiya
Hirotoshi
H
Inada
Ken-Ichi
K
Yamada
Tomoki
T
Okuno
Yoshiharu
Y
Tanaka
Harunari
H
Tatematsu
Masae
M
D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D000432:Methanol; D027861:Prunus / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D005663:Furans; D017705:Lignans; D012997:Solvents; C042192:syringaresinol; D000432:Methanol