[Recent advances in proPSA on early detection in prostate cancer].
The precursor of prostate specific antigen (proPSA) are distinct molecular forms of free PSA in serum. proPSA is comprised of native proPSA as well as several truncated forms, in which [-2] proPSA and [-4] proPSA are more prostate cancer (PCa)-associated than [-7] proPSA and [-5] proPSA. Clinical studies have recently provided evidence that [-2] proPSA can significantly improve the detection of PCa, particularly in patients with total serum PSA values less than 4 microg/L. In this paper, the mechanism and characteristics of proPSA formation and impact of proPSA on the early detection of PCa are reviewed.
Zhu
Pei-yuan
PY
Laboratory of Immunohematology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China. wjzhu@jlonline.com
Hong
Ping
P
Huang
Yu-feng
YF
D042241:Early Diagnosis; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood* / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D011498:Protein Precursors / Q000097:blood* / Q000737:chemistry; D012680:Sensitivity and Specificity
D011498:Protein Precursors; D017430:Prostate-Specific Antigen