title: Correlation of exhaled nitric oxide, spirometry and asthma symptoms.
abstract: Asthma is the most common chronic disease of childhood. Asthma severity is monitored by spirometry. However, this does not directly measure airway inflammation. Exhaled nitric oxide (FeNO) is a proposed method to measure airway inflammation non-invasively. Previous studies have shown that FeNO correlates with endobronchial biopsies and symptoms in patients with asthma. We monitored daily asthma symptoms compared to monthly spirometry and FeNO. Total monthly symptom scores correlated with both forced expiratory volume at 1 sec (FEV1) and FeNO. FeNO had a strong correlation than FEV1. FeNO and FEV1 were not correlated. We propose that FeNO should be used as an additional monitoring tool for asthma.
authors.affiliation: Allergy Section, Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. spergel@email.chop.edu
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Spergel
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Fogg
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Bokszczanin-Knosala
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D045853:Exhalation; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*; D011014:Pneumonia / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D013147:Spirometry
chemical_list: D009569:Nitric Oxide