title: Poor outcome of adult acute lymphoblastic leukemia patients carrying the (1;19)(q23;p13) translocation.
abstract: The (1;19)(q23;p13) translocation, leading to the production of the E2A/PBX1 fusion transcript, is one of the most common translocations in pediatric B-lineage acute lymphoblastic leukemia (ALL). It was assumed to be associated with a poor clinical outcome, although intensive therapy and bone marrow transplantation have been shown to be able to overcome the negative prognostic impact. Only few data are available concerning t(1;19)(q23;p13) in adult ALL. In particular, the prognostic significance of this genetic aberration is not yet clear. We describe three cases of adult ALL carrying the t(1;19)(q23;p13), who were all characterized by an aggressive clinical course and short survival, and discuss the molecular features of the disease as recently identified by gene expression profiling.
authors.affiliation: Institute of Haematology and Medical Oncology 'L. and A. Serànoli', S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. ppicca@med.unibo.it
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Piccaluga
authors.forename: Michele
authors.initials: M
authors.lastname: Malagola
authors.forename: Michela
authors.initials: M
authors.lastname: Rondoni
authors.forename: Emanuela
authors.initials: E
authors.lastname: Ottaviani
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Testoni
authors.forename: Claudio
authors.initials: C
authors.lastname: Laterza
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Visani
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Pileri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
authors.forename: Michele
authors.initials: M
authors.lastname: Baccarani
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D011379:Prognosis; D012008:Recurrence; D014178:Translocation, Genetic; D017211:Treatment Failure