title: CDKN2A common variant and multi-organ cancer risk--a population-based study.
abstract: The population frequencies of the CDKN2A common variants remain undetermined. In Poland, there is a common variant of the CDKN2A: an alanine to threonine substitution (A148T), which has been detected in other populations. We have recently showed that it is significantly overrepresented among Polish melanoma patients when compared to general population. Herein, we ascertained the prevalence of the A148T variant in 3,583 unselected cancer cases and 3,000 random control subjects from the same Polish population. We evaluated eleven different malignancies, representing the majority of all common cancer sites. Positive association with A148T variant was observed for lung cancer (OR, 2.0; p = 0.0052). A similar trend, although nonsignificant after the Bonferroni correction, was observed for colorectal cancer (OR, 1.5; p = 0.5499). These results suggest that A148T variant may be associated with a multi-organ cancer risk in the Polish population.
authors.affiliation: Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. debniak@wp.pl
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Debniak
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Scott
authors.forename: Tomasz
authors.initials: T
authors.lastname: Huzarski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Byrski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Rozmiarek
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Debniak
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Medrek
authors.forename: Marek
authors.initials: M
authors.lastname: Mierzejewski
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Masojc
authors.forename: Joanna
authors.initials: J
authors.lastname: Matyjasik
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Złowocka
authors.forename: Urszula
authors.initials: U
authors.lastname: Teodorczyk
authors.forename: Marcin
authors.initials: M
authors.lastname: Lener
authors.forename: Ewa
authors.initials: E
authors.lastname: Klujszo-Grabowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Nej-Wołosiak
authors.forename: Ewa
authors.initials: E
authors.lastname: Jaworowska
authors.forename: Dorota
authors.initials: D
authors.lastname: Oszutowska
authors.forename: Anna
authors.initials: A
authors.lastname: Szymańska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Szymańska
authors.forename: Jennifer
authors.initials: J
authors.lastname: Castaneda
authors.forename: Thierry
authors.initials: T
authors.lastname: van de Wetering
authors.forename: Janina
authors.initials: J
authors.lastname: Suchy
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kurzawski
authors.forename: Oleg
authors.initials: O
authors.lastname: Oszurek
authors.forename: Steven
authors.initials: S
authors.lastname: Narod
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
mesh_terms: D000328:Adult; D000368:Aged; D000409:Alanine; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics*; D005260:Female; D019942:Genes, p16; D014644:Genetic Variation; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013912:Threonine
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D013912:Threonine; D000409:Alanine