Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population.
AKT1 (V-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of AKT. Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia. We tested for the presence of these five single-nucleotide polymorphisms in a Taiwanese population by genotyping 218 co-affected schizophrenia families. Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population.
Liu
Yu-Li
YL
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Fann
Cathy Shen-Jang
CS
Liu
Chih-Min
CM
Wu
Jer-Yuarn
JY
Hung
Shuen-Iu
SI
Chan
Hung-Yu
HY
Chen
Jiahn-Jyh
JJ
Pan
Chia-Ching
CC
Liu
Shih-Kai
SK
Hsieh
Ming H
MH
Hwang
Tzung-Jeng
TJ
Ouyang
Wen-Chen
WC
Chen
Chun-Ying
CY
Lin
Jin-Jia
JJ
Chou
Frank Huang-Chih
FH
Chueh
Ching-Mo
CM
Liu
Wei-Ming
WM
Tsuang
Ming-Ming
MM
Faraone
Stephen V
SV
Tsuang
Ming T
MT
Chen
Wei J
WJ
Hwu
Hai-Gwo
HG
D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013624:Taiwan
D005819:Genetic Markers; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt