Anti-inflammatory activity of Coldenia procumbens Linn.
Anti-inflammatory activity of the ethanolic extract of the aerial parts of Coldenia procumbens Linn. was studied in Wister rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract (150 mg/kg, p.o.) produced the inhibition of carrageenan induced rat paw edema. It also showed an inhibitory effect on leukocyte migration and a reduction on the pleural exudates as well as reduction on the granuloma weight in the cotton pellet granuloma method. The results indicated that the ethanolic extract produced significant (P<0.001) anti-inflammatory activity when compared with the standard and untreated control.
Arul
B
B
Department of Pharmaceutics, Vinayaka Mission's College of Pharmacy, Yercaud Main Road, Salem-636 008, Tamilnadu, India. arul1971@yahoo.com
Kothai
R
R
Sureshkumar
K
K
Christina
A J M
AJ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D028082:Boraginaceae; D004487:Edema / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts