Induction of gamma-turn-like structure in ferrocene bearing dipeptide chains via conformational control.
[structure: see text] A combination of the ferrocene scaffold as a central reverse-turn unit with the dipeptide chains (-L-Pro-L-Ala-NHPy) was demonstrated to induce both inverse gamma-turn-like and antiparallel beta-sheet-like structures. Only the antiparallel beta-sheet-like structure was formed in the ferrocene bearing the heterochiral dipeptide chains (-L-Pro-D-Ala-NHPy), in which highly organized self-assembly was achieved through a network of intermolecular hydrogen bonds.
Moriuchi
Toshiyuki
T
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamada-oka, Suita, Japan.
Nagai
Takayoshi
T
Hirao
Toshikazu
T
D004151:Dipeptides / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D000075163:Metallocenes; D019906:Nuclear Magnetic Resonance, Biomolecular; D011487:Protein Conformation; D014961:X-Ray Diffraction
D004151:Dipeptides; D005296:Ferrous Compounds; D000075163:Metallocenes; C004998:ferrocene