title: Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization.
abstract: Large uniform-sized polymer beads are desirable for "one-bead-one-compound" applications in the combinatorial synthesis of compound libraries. We have developed a technique for the preparation of large polymer spheres with narrow size distributions. Uniform-sized poly(styrene-co-divinylbenzene) beads with diameters in excess of 1 mm have been prepared by free radical polymerization in an ascension process through a heated column. The size of the beads can be adjusted by the diameter of the injection needle and the injection speed. The resin beads can be made porous by the incorporation of a porogen during the preparation; they reach a specific surface area in excess of 200 m(2)/g. The mechanical properties of the spheres and their use in organic synthesis have been studied.
authors.affiliation: Département de Chimie, Université de Montréal, C. P. 6128, succursale Centre-ville, Montréal, QC, H3C 3J7, Canada. julian.zhu@umontreal.ca
authors.forename: X X
authors.initials: XX
authors.lastname: Zhu
authors.forename: J H
authors.initials: JH
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Gauthier
authors.forename: J T
authors.initials: JT
authors.lastname: Luo
authors.forename: F S
authors.initials: FS
authors.lastname: Meng
authors.forename: F
authors.initials: F
authors.lastname: Brisse
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003432:Cross-Linking Reagents / Q000737:chemistry; D008422:Materials Testing; D008863:Microspheres; D010316:Particle Size; D011137:Polystyrenes / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity; D012117:Resins, Synthetic / Q000138:chemical synthesis* / Q000737:chemistry; D013314:Stress, Mechanical
chemical_list: D003432:Cross-Linking Reagents; D011137:Polystyrenes; D012117:Resins, Synthetic; C003771:Amberlite XAD-2 resin