Different modes of action of naphthyridones in gram-positive and gram-negative bacteria.
Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.
Buurman
Ed T
ET
Department of Microbiology, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachuetts 02451, USA. Ed.Buurman@astrazeneca.com
Johnson
Kenneth D
KD
Kelly
Roxanne K
RK
MacCormack
Kathy
K
D000890:Anti-Infective Agents / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009287:Naphthyridines / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D009287:Naphthyridines