Hyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: protective role of melatonin.
OBJECTIVE
The present study aimed at determining how 3-week intraperitoneal melatonin administration affected oxidative stress caused by experimental hyperthyroidism.


METHODS
The study was conducted on 30 male rats of Sprague-Dawley species. The experimental animals were divided to 3 groups (control, hyperthyroidism and hyperthyroidism+melatonin). The supplementation was continued for 3 weeks after which the animals were sacrificed and tissue malondyaldehyde (MDA) and glutathione (GSH) levels were determined.


RESULTS
MDA levels in kidney and testis tissues in hyperthyroidism group were higher than those in control and hyperthyroidism+melatonin administered groups (p<0.001) and levels in hyperthyroidism+melatonin administered group were higher than those in the control group (p<0.001). The highest GSH levels were obtained in hyperthyroidism+melatonin-administered group (p<0.001) and GSH levels in hyperthyroidism group were higher than those in the control group (p<0.001).


CONCLUSIONS
Results of the study demonstrate that hyperthyroidism induced by 3-week L-thyroxine administration increased oxidative stress in kidney and testis tissues and that although melatonin administration inhibited this stress to a certain extent, it could not bring the stress down to the level in controls.
Mogulkoc
Rasim
R
Department of Physiology, Meram Medical School, Selcuk University, 42080 Konya, Turkey. rasimmogulkoc@yahoo.com
Baltaci
Abdulkerim Kasim
AK
Oztekin
Esma
E
Aydin
Leyla
L
Tuncer
Isik
I
D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000378:metabolism*; D013974:Thyroxine
D008315:Malondialdehyde; D005978:Glutathione; D008550:Melatonin; D013974:Thyroxine