Vitamin E in the treatment of uveitis-associated macular edema.
OBJECTIVE
To investigate whether high-dose alpha-tocopherol (vitamin E) could reduce vision loss and retinal thickening associated with uveitis-associated cystoid macular edema.


METHODS
A double-masked, randomized study.


METHODS
Uveitis patients with macular edema seen at the NIH were randomized and received either 1600 IU/day of vitamin E or placebo for 4 months. Visual acuity and retinal thickening were collected for the efficacy and the safety of the high dose of vitamin E.


RESULTS
Changes in visual acuity and retinal thickening.


CONCLUSIONS
Four-month oral supplementation with 1600 IU/d of vitamin E had no apparent effect on uveitis-associated macular edema or visual acuity in this small study.
Nussenblatt
Robert B
RB
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Rm. 10S219, 10 Center Drive, Bethesda, MD 20892, USA. drbob@nei.nih.gov
Kim
Jonghyeon
J
Thompson
Darby J S
DJ
Davis
Matthew D
MD
Chew
Emily
E
Ferris
Frederick L
FL
Buggage
Ronald
R
D000328:Adult; D000368:Aged; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000187:drug effects; D014605:Uveitis / Q000150:complications / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E