Biological studies of photoinducible phenol quaternary ammonium derivatives.
Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.
Song
Yang
Y
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
Wang
Ping
P
Wu
Juanjuan
J
Zhou
Xiang
X
Zhang
Xiao-Lian
XL
Weng
Linhong
L
Cao
Xiaoping
X
Liang
Feng
F
D017209:Apoptosis / Q000187:drug effects*; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D005434:Flow Cytometry; D008027:Light; D010636:Phenols / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D003432:Cross-Linking Reagents; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D004247:DNA