title: [The changes of some vasoactive substances after operation in patients with obstructive sleep apnea-hypopnea syndrome].
abstract: OBJECTIVE
  To observe the changes of thromboxane B2 (TXB2), rennin, angiotensin II (AT-II), endothelin 1 (ET-1) and anticardiolipin antibody (ACA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the operation.
  
  
  METHODS
  Fifty-four cases of OSAHS confirmed by polysomnography (PSG) were selected as the OSAHS group and 20 normal donors without OSAHS were selected as the control group. Plasma levels of TXB2, rennin, AT- II, ET-1 and ACA were detected by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Plasma levels of TXB2, rennin, AT-II, ET-1 and ACA were higher in patients with OSAHS than those in control group (P < 0.05 or P < 0.01), and the operation therapy decreased them significantly (P < 0.05 or P <0.01). All the plasma parameters were correlated positively with AHI, and negatively with SaO2.
  
  
  CONCLUSIONS
  The results indicate the patients with OSAHS were susceptible to thromboembolism disease. Operation therapy is effective in correcting TXB2, rennin, AT-II, ET-1 and ACA.
authors.affiliation: Department of Otolaryngology, Wuhan General Hospital of PLA, Wuhan, 430070, China. yaohq64@sohu.com
authors.forename: Xingqi
authors.initials: X
authors.lastname: Yao
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: Chu
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Luo
authors.forename: Guifeng
authors.initials: G
authors.lastname: Zhang
authors.forename: Lun
authors.initials: L
authors.lastname: Wang
mesh_terms: D000804:Angiotensin II / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016022:Case-Control Studies; D012085:Chymosin / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D006801:Humans; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery*; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D017152:Antibodies, Antiphospholipid; D019332:Endothelin-1; D000804:Angiotensin II; D013929:Thromboxane B2; D012085:Chymosin