title: Adolescents carrying a missense mutation in the CART gene exhibit increased anxiety and depression.
abstract: A Leu34Phe mutation in the cocaine- and amphetamine-regulated transcript (CART) gene has been associated with severe early-onset obesity in an affected family. It has been shown that, in a cell culture system, the mutation resulted in altered CART peptide levels, and animal studies suggest that CART is involved in anxiety as well. The availability of the affected family allowed for testing of anxiety and other traits in humans carrying a mutation in CART gene. This study shows that a small group of adolescents with the mutation exhibit higher anxiety and depression scores than control subjects.
authors.affiliation: Department of Pediatrics, Second University of Naples, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Miraglia del Giudice
authors.forename: N
authors.initials: N
authors.lastname: Santoro
authors.forename: P
authors.initials: P
authors.lastname: Fiumani
authors.forename: G
authors.initials: G
authors.lastname: Dominguez
authors.forename: M J
authors.initials: MJ
authors.lastname: Kuhar
authors.forename: L
authors.initials: L
authors.lastname: Perrone
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001007:Anxiety / Q000235:genetics*; D003863:Depression / Q000235:genetics*; D006801:Humans; D020125:Mutation, Missense; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
chemical_list: D009419:Nerve Tissue Proteins; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein