Insect neuropeptide and peptide hormone receptors: current knowledge and future directions.
Peptides form a very versatile class of extracellular messenger molecules that function as chemical communication signals between the cells of an organism. Molecular diversity is created at different levels of the peptide synthesis scheme. Peptide messengers exert their biological functions via specific signal-transducing membrane receptors. The evolutionary origin of several peptide precursor and receptor gene families precedes the divergence of the important animal Phyla. In this chapter, current knowledge is reviewed with respect to the analysis of peptide receptors from insects, incorporating many recent data that result from the sequencing of different insect genomes. Therefore, detailed information is provided on six different peptide receptor families belonging to two distinct receptor categories (i.e., the heptahelical and the single transmembrane receptors). In addition, the remaining problems, the emerging concepts, and the future prospects in this area of research are discussed.
Claeys
Ilse
I
Laboratory for Developmental Physiology, Genomics and Proteomics Department of Animal Physiology and Neurobiology, Zoological Institute K.U.Leuven, Naamsestraat 59, B-3000 Leuven, Belgium.
Poels
Jeroen
J
Simonet
Gert
G
Franssens
Vanessa
V
Van Loy
Tom
T
Van Hiel
Matthias B
MB
Breugelmans
Bert
B
Vanden Broeck
Jozef
J
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D005544:Forecasting; D051157:Frizzled Receptors / Q000235:genetics / Q000502:physiology; D007313:Insecta / Q000235:genetics* / Q000502:physiology*; D007447:Invertebrate Hormones / Q000235:genetics / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology; D011964:Receptors, Gastrointestinal Hormone / Q000235:genetics / Q000502:physiology; D050705:Receptors, Guanylate Cyclase-Coupled / Q000235:genetics / Q000502:physiology; D018010:Receptors, Invertebrate Peptide / Q000235:genetics* / Q000502:physiology*; D018000:Receptors, Peptide / Q000235:genetics / Q000502:physiology; D018039:Receptors, Tachykinin / Q000235:genetics / Q000502:physiology; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology
D029721:Drosophila Proteins; C055209:FMRFamide receptor; D051157:Frizzled Receptors; D007447:Invertebrate Hormones; C474930:Proc-R protein, Drosophila; D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; D018010:Receptors, Invertebrate Peptide; D018000:Receptors, Peptide; D018039:Receptors, Tachykinin; D018125:Receptors, Transforming Growth Factor beta; C029937:secretin receptor; C002295:bursicon; D020794:Receptor Protein-Tyrosine Kinases; D050705:Receptors, Guanylate Cyclase-Coupled