Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery.
OBJECTIVE
We investigated changes in serum uric acid across pregnancy in women with gestational hyperuricemia at delivery, with and without preeclampsia, compared with normal pregnant and women with preeclampsia without gestational hyperuricemia.


METHODS
This was a nested case-control study of 116 controls, 27 women with preeclampsia with predelivery hyperuricemia, 37 women with preeclampsia without predelivery hyperuricemia, and 35 women with gestational hypertension with hyperuricemia at delivery but without proteinuria. Serum uric acid and creatinine was measured across pregnancy.


RESULTS
Women with predelivery hyperuricemia, with and without preeclampsia, had increased uric acid concentrations across pregnancy compared with controls, after 25 weeks' gestation compared with women with preeclampsia without predelivery hyperuricemia. Adjusting for differences in glomerular filtration by serum creatinine accounted for part but not all of the increase in serum uric acid among women with preeclampsia and predelivery hyperuricemia.


CONCLUSIONS
Among women with hyperuricemia at delivery, elevations in uric acid occur early. Multiple mechanisms may contribute to increased uric acid including changes in renal function.
Powers
Robert W
RW
Magee-Womens Research Institute, Pittsburgh, PA 15213, USA. rsirwp@mwri.magee.edu
Bodnar
Lisa M
LM
Ness
Roberta B
RB
Cooper
Katheryn M
KM
Gallaher
Marcia J
MJ
Frank
Michael P
MP
Daftary
Ashi R
AR
Roberts
James M
JM
D000328:Adult; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D036861:Delivery, Obstetric; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000503:physiopathology; D009994:Osmolar Concentration; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000097:blood* / Q000503:physiopathology; D011261:Pregnancy Trimester, First; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D003404:Creatinine