[Peculiarities of hepatic experimental wound healing in rats treated with angiogenin].
Gel, containing recombinant human angiogenin (0.1 ml), was applied upon the injured liver (experimental wedge-shaped resection) of adult rats. Histological study has demonstrated that in animals treated with angiogenin, the zone of purulent-necrotic inflammation was reduced at already the early stages of an experiment, while by day 7 the scar was formed that was represented by a mature connective tissue free from inflammatory phenomena. Increased number of binucleate hepatocytes, positive time course of mononuclear hepatocyte/degenerating cell ratio also indicate the stimulation of regeneration processes in rat liver parenchyma, that is corroborated by the results of biochemical analysis of blood.
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D005782:Gels; D022781:Hepatocytes / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects*; D051381:Rats; D012259:Ribonuclease, Pancreatic / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D043925:Angiogenesis Inducing Agents; D005782:Gels; C046366:angiogenin; D012259:Ribonuclease, Pancreatic