Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives.
Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type 1 or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10(-3)). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10(-4)). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.
Besson
Caroline
C
Laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté Necker, Université de Paris René Descartes INSERM U550, France.
Amiel
Corinne
C
Le-Pendeven
Catherine
C
Brice
Pauline
P
Fermé
Christophe
C
Carde
Patrice
P
Hermine
Olivier
O
Raphael
Martine
M
Abel
Laurent
L
Nicolas
Jean-Claude
JC
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000276:immunology; D036022:Capsid Proteins / Q000276:immunology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology / Q000821:virology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008223:Lymphoma / Q000145:classification / Q000276:immunology / Q000821:virology*; D008297:Male; D014412:Tumor Virus Infections / Q000276:immunology*; D019562:Viral Load
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D007074:Immunoglobulin G