Prenatal diagnosis in human immunodeficiency virus-infected women: a new screening program for chromosomal anomalies.
OBJECTIVE
This study was undertaken to describe a new prenatal diagnosis program among human immunodeficiency virus (HIV)-infected women, and the perinatal outcome of this program's application over a more than 2-year period.


METHODS
From June 2000 to December 2003, all HIV-infected women who were booked into the antenatal clinic before 20 weeks were offered a screening for chromosomal anomalies, with midtrimester amniocentesis in the tests that were positive.


RESULTS
A total of 116 pregnancies (including 3 sets of twins) were seen: 96 women were offered and accepted screening for chromosomal anomalies. Thirteen pregnancies had a positive screening test and amniocentesis was performed in 10 at median 16.5 gestational weeks: a trisomy 21 and a monosomy X were diagnosed. No vertical transmissions were documented by age 6 months in the 6 liveborn infants who underwent amniocentesis.


CONCLUSIONS
A program of prenatal diagnosis for chromosomal anomalies appears to be effective when applied to HIV-infected women, although safety remains to be proven.
Coll
Oriol
O
Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Barcelona, Spain.
Suy
Anna
A
Hernandez
Sandra
S
Pisa
Sonia
S
Lonca
Montserrat
M
Thorne
Claire
C
Borrell
Antoni
A
D000328:Adult; D000649:Amniocentesis; D023241:Antiretroviral Therapy, Highly Active; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000175:diagnosis*; D002891:Chromosomes, Human, Pair 21; D041321:Chromosomes, Human, X; D005260:Female; D005820:Genetic Testing; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D009006:Monosomy / Q000175:diagnosis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D014314:Trisomy / Q000175:diagnosis