title: Typhoid fever in Dhulikhel hospital, Nepal.
abstract: One hundred and twelve cases of typhoid fever presenting in outpatient and emergency department of Dhulikhel Hospital in Nepal were studied. In this study, it was found that 71% typhoid fever cases were less than 30 years of age group with male to female ratio of 3:1. Fever over 5 days followed by headache and chills were major presenting symptoms. Widal test and blood culture for Salmonella typhi were positive in 59% and 49% cases respectively. Two third of our study population had total leucocyte count of normal range. The fever clearance time was significantly better with ofloxacin compared to ciprofloxacin (p < 0.05) and ceftriaxone compared to chloramphenicol (p < 0.05). The release from treatment was significantly shorter with ceftriaxone compared to ofloxacin, ciprofloxacin and chloramphenicol (p < 0.01). Ceftriaxone was found to be 100% sensitive to salmonella typhi. Amoxicillin was only 52.1% sensitive to Salmonella typhi. Early diagnosis and institution of appropriate antibiotic therapy is of paramount importance in the management of typhoid patients.
authors.affiliation: Kathmandu University Teaching Hospital, Dhulikhel. dhos@mail.com.np
authors.forename: N
authors.initials: N
authors.lastname: Sharma
authors.forename: R
authors.initials: R
authors.lastname: Koju
authors.forename: B
authors.initials: B
authors.lastname: Karmacharya
authors.forename: M-D
authors.initials: MD
authors.lastname: Tamang
authors.forename: R
authors.initials: R
authors.lastname: Makaju
authors.forename: N
authors.initials: N
authors.lastname: Nepali
authors.forename: P
authors.initials: P
authors.lastname: Shrestha
authors.forename: D
authors.initials: D
authors.lastname: Adhikari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009390:Nepal; D014435:Typhoid Fever / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents