title: Antidiabetic effects of ajoene in genetically diabetic KK-A(y) mice.
abstract: Antidiabetic effects of ajoene, derived from garlic, were investigated in genetically diabetic KK-A(y) mice. Four-week-old male KK-A(y) mice were kept on a laboratory diet containing 0.02 or 0.05% of ajoene for 8 wk. The elevation of water intake was suppressed depending on ajoene intake. The levels of plasma glucose in the 0.05% ajoene-containing diet group was significantly suppressed to 73.8% compared with the control group at the 8th wk. Similarly, the plasma triglyceride level was significantly suppressed. It is suggested that hyperglycemia and hypertriglyceridemia are suppressed by ajoene treatment.
authors.affiliation: Biodevelopment Division, Central Institute, Nagoya Seiraku Co. Ltd., 310 Nakasuna-cho, Tempaku-ku, Nagoya, Aichi 468-0065, Japan.
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hattori
authors.forename: Norihiko
authors.initials: N
authors.lastname: Yamada
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fukuda
authors.forename: Tsuchiyoshi
authors.initials: T
authors.lastname: Fujino
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D004220:Disulfides / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D004326:Drinking / Q000187:drug effects; D005737:Garlic / Q000737:chemistry; D006943:Hyperglycemia / Q000188:drug therapy / Q000503:physiopathology; D015228:Hypertriglyceridemia / Q000188:drug therapy / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013454:Sulfoxides; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D004220:Disulfides; D007004:Hypoglycemic Agents; D013454:Sulfoxides; D014280:Triglycerides; C048980:ajoene