title: Bilirubin oxidase activity of Bacillus subtilis CotA.
abstract: The spore coat protein CotA from Bacillus subtilis was previously identified as a laccase. We have now found that CotA also shows strong bilirubin oxidase activity and markedly higher affinity for bilirubin than conventional bilirubin oxidase. This is the first characterization of bilirubin oxidase activity in a bacterial protein.
authors.affiliation: Asahi Kasei Pharma Corporation, Shizuoka 410-2321, Japan. sakasegawa.sb@om.asahi-kasei.co.jp.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Sakasegawa
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Imamura
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sakuraba
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Goda
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Ohshima
mesh_terms: D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000201:enzymology* / Q000502:physiology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood; D004795:Enzyme Stability; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D042845:Laccase; D008969:Molecular Sequence Data; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000737:chemistry / Q000378:metabolism*; D013171:Spores, Bacterial / Q000737:chemistry
chemical_list: D001426:Bacterial Proteins; D042845:Laccase; D044925:Oxidoreductases Acting on CH-CH Group Donors; C042401:bilirubin oxidase; D001663:Bilirubin