title: Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor gamma.
abstract: A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator-activated receptor gamma with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors alpha and sigma. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-alpha and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.
authors.affiliation: Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Jeong Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Xing Fu
authors.initials: XF
authors.lastname: Cai
authors.forename: Jin Chul
authors.initials: JC
authors.lastname: Shin
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Hong
authors.forename: Jung Joon
authors.initials: JJ
authors.lastname: Lee
mesh_terms: D003512:Cyclohexanones / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D018942:Macrolides / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D047495:PPAR gamma / Q000187:drug effects / Q000378:metabolism*
chemical_list: D003512:Cyclohexanones; D018942:Macrolides; D047495:PPAR gamma; C453419:sorbicillinol; D009569:Nitric Oxide