The neurobiology of postpartum depression.
Postpartum psychiatric changes can range from maternity blues to psychosis. Causality is still undetermined, but explanations for these disturbances often focus on hormonal changes and dysregulation. Researchers have begun the process of delineating what neurobiological factors may be associated with depressive disorders in pregnancy and the postpartum. This article reviews the current literature on the roles of gonadal and pituitary hormones in the psychopathophysiology of postpartum mood disorders. Other biological factors, such as biogenic amines, neuroactive steroids, cholesterol, and fatty acids, are also discussed. The potential benefits of neuroimaging to aid in understanding neuropsychiatric changes that occur in the context of postpartum depression are also considered.
Zonana
Jessica
J
New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY, USA. jez9004@nyp.org
Gorman
Jack M
JM
D001921:Brain / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood; D019052:Depression, Postpartum / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D005227:Fatty Acids / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D010907:Pituitary Hormones / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology
D005227:Fatty Acids; D012739:Gonadal Steroid Hormones; D010907:Pituitary Hormones; D002784:Cholesterol