title: Auto-redox reaction: tin(II) chloride-mediated one-step reductive cyclization leading to the synthesis of novel biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity.
abstract: [reaction: see text] A tin(II) chloride-mediated short, efficient, and practical regioselective synthesis of biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity is reported. A one-step reductive transformation of 2-(2-nitrophenyl)-3H-quinazolin-4-one in various alcohols furnished the desired tetracyclic product in good yields with high purity.
authors.affiliation: Division of SAIF, Central Drug Research Institute, Lucknow 226 001, India.
authors.forename: Abhijeet Deb
authors.initials: AD
authors.lastname: Roy
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Subramanian
authors.forename: Raja
authors.initials: R
authors.lastname: Roy
mesh_terms: D002712:Chlorides / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D014001:Tin / Q000737:chemistry*
chemical_list: D002712:Chlorides; D011799:Quinazolines; D014001:Tin