MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients.
BACKGROUND
The multidrug resistance MDR1 gene codes for a membrane transporter associated with inflammatory bowel disease. The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC). We studied the association of both polymorphisms in an independent population to reveal the impact of the MDR1 gene on predisposition to inflammatory bowel disease.


METHODS
Case-control study with 321 CD and 330 UC white Spanish patients recruited from the same center, and 352 healthy ethnically matched controls.


RESULTS
A significant association of MDR1 C3435T with CD was observed (CC vs (CT + TT): P = 0.007; OR [95% CI] = 1.58 [1.12-2.23]). A CD susceptibility haplotype 2677T/C3435 was identified. No difference between UC patients as a whole and controls could be detected.


CONCLUSIONS
New evidence supports the role of the MDR1 gene on CD susceptibility. Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC. We discovered that the C3435 allele conferring susceptibility to CD is different from the described 3435T UC risk allele.
Urcelay
Elena
E
Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain. eurcelay@hcsc.es
Mendoza
Juan L
JL
Martín
M Carmen
MC
Mas
Ana
A
Martínez
Alfonso
A
Taxonera
Carlos
C
Fernandez-Arquero
Miguel
M
Díaz-Rubio
Manuel
M
de la  Concha
Emilio G
EG
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D019450:Genes, MDR; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013030:Spain; D044465:White People