title: Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease.
abstract: OBJECTIVE
  Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects.
  
  
  METHODS
  Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [(123)I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K(1)).
  
  
  RESULTS
  Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K(1).
  
  
  CONCLUSIONS
  These results indicate the importance of extending the study to demented patients.
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3-10, I Center Drive, MSC-0135, Bethesda, MD, USA. fujitam@intra.nimh.nih,gov
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujita
authors.forename: Masanori
authors.initials: M
authors.lastname: Ichise
authors.forename: Sami S
authors.initials: SS
authors.lastname: Zoghbi
authors.forename: Jeih-San
authors.initials: JS
authors.lastname: Liow
authors.forename: Subroto
authors.initials: S
authors.lastname: Ghose
authors.forename: Douglass C
authors.initials: DC
authors.lastname: Vines
authors.forename: Janet
authors.initials: J
authors.lastname: Sangare
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Lu
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Cropley
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Iida
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Robert M
authors.initials: RM
authors.lastname: Cohen
authors.forename: William
authors.initials: W
authors.lastname: Bara-Jimenez
authors.forename: Bernard
authors.initials: B
authors.lastname: Ravina
authors.forename: Robert B
authors.initials: RB
authors.lastname: Innis
mesh_terms: D000368:Aged; D001384:Azetidines / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001384:Azetidines; D007457:Iodine Radioisotopes; D011725:Pyridines; D011978:Receptors, Nicotinic; C023666:pyridine