Antidiabetic potential of Butea monosperma in rats.
The antihyperglycemic activity of the ethanolic extract of Butea monosperma (BMEE) was studied in glucose-loaded and alloxan-induced diabetic rats. Single dose treatment of BMEE (200 mg/kg, p.o.) significantly improved glucose tolerance and caused reduction in blood glucose level in alloxan-induced diabetic rats. Repeated oral treatment with BMEE (200 mg/kg/day) for 2 weeks significantly reduced blood glucose, serum cholesterol and improved HDL-cholesterol and albumin as compared to diabetic control group.
Somani
Rahul
R
NDMVP's College of Pharmacy, Nashik, India. rahulsomani2001@yahoo.com
Kasture
Sanjay
S
Singhai
Abhay Kumar
AK
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D031290:Butea / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000032:analysis / Q000187:drug effects; D003920:Diabetes Mellitus / Q000188:drug therapy; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D000431:Ethanol / Q000737:chemistry; D005260:Female; D035264:Flowers / Q000737:chemistry; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D008076:Cholesterol, HDL; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000431:Ethanol; D002784:Cholesterol