title: Steroid-free immunosuppression for pancreas-after-liver transplantation.
abstract: Simultaneous pancreas-kidney transplantation is presently a well-accepted procedure for patients with type 1 diabetes mellitus and renal failure. However, experiences with combined pancreas and liver transplantation are scarce, a few data are available about the best immunosuppression for these patients. We report our experience with two patients who received a pancreas after liver transplantation for long-standing insulin-dependent diabetes mellitus, with steroid-free immunosuppression based on daclizumab, tacrolimus, and mycophenolate mofetil. Short- and long-term evolution was uneventful. Currently, both patients are insulin free with appropriate metabolic control after 12 and 6 months follow-up. Considering our preliminary results, we suggest a steroid-free immunosuppressive regimen as an option for pancreas-after-liver transplantation.
authors.affiliation: Transplant Unit, Juan Canalejo University Hospital, La Coruña, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Suárez
authors.forename: A
authors.initials: A
authors.lastname: Otero
authors.forename: J
authors.initials: J
authors.lastname: Quintela
authors.forename: J
authors.initials: J
authors.lastname: Aguirrezabalaga
authors.forename: B
authors.initials: B
authors.lastname: Gala
authors.forename: M
authors.initials: M
authors.lastname: Gómez
mesh_terms: D000305:Adrenal Cortex Hormones; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D006432:Hemochromatosis / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents