Disruption of the bradyzoite-specific P-type (H+)-ATPase PMA1 in Toxoplasma gondii leads to decreased bradyzoite differentiation after stress stimuli but does not interfere with mature tissue cyst formation.
Holpert
Mathias
M
Institute of Medical Microbiology, University of Göttingen, Kreuzbergring 57, Göttingen D-37075, Germany.
Gross
Uwe
U
Bohne
Wolfgang
W
D000818:Animals; D001921:Brain / Q000469:parasitology; D003470:Culture Media / Q000494:pharmacology; D017931:DNA Primers / Q000737:chemistry; D018274:Electroporation / Q000379:methods; D019084:Fluorescent Antibody Technique, Indirect / Q000379:methods; D020869:Gene Expression Profiling; D006360:Heat-Shock Proteins / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007527:Isoenzymes / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008018:Life Cycle Stages / Q000235:genetics / Q000502:physiology*; D051379:Mice; D016297:Mutagenesis, Site-Directed / Q000379:methods; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009693:Nucleic Acid Hybridization; D006180:Proton-Translocating ATPases / Q000502:physiology*; D015800:Protozoan Proteins / Q000032:analysis; D014122:Toxoplasma / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D014617:Vacuoles
C106179:BAG1 protein, Toxoplasma; D003470:Culture Media; D017931:DNA Primers; D006360:Heat-Shock Proteins; D007527:Isoenzymes; D020030:Nitric Oxide Donors; D015800:Protozoan Proteins; D007770:L-Lactate Dehydrogenase; C409676:lactate dehydrogenase 2; D006180:Proton-Translocating ATPases