Mechanisms of abnormal gene expression in tumor cells.
Epigenetic mechanisms are involved in critical nuclear processes such as transcriptional control, genome stability, replication and repair. Recent evidence suggests that changes in the epigenetic repertoire can drive tumorigenesis. This review examines the latest experimental evidence that questions the mechanisms underlying the consequence of epigenetic changes in gene regulation and cancer development.
El-Osta
Assam
A
The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor Commercial Road, Prahran, Victoria 3181, Australia. assam.el-osta@baker.edu.au
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism
D002843:Chromatin; D004247:DNA; D008780:Methyltransferases