Chromatin, transcript elongation and alternative splicing.
A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed.
Kornblihtt
Alberto R
AR
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D002843:Chromatin / Q000235:genetics*; D006801:Humans; D007700:Kinetics; D012319:RNA Polymerase II / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
D002843:Chromatin; C084011:SMARCA2 protein, human; D014157:Transcription Factors; D012319:RNA Polymerase II