Expanding the scope of Lewis acid catalysis in water: remarkable ligand acceleration of aqueous ytterbium triflate catalyzed Michael addition reactions.
[reaction: see text] Significant rate acceleration of metal-catalyzed Michael addition reactions in water was observed upon addition of small, dibasic ligands. Ytterbium triflate and TMEDA was the most effective combination leading to a nearly 20-fold faster reaction than in the absence of ligand.
Ding
Rui
R
Department of Organic Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
Katebzadeh
Kambiz
K
Roman
Lisa
L
Bergquist
Karl-Erik
KE
Lindström
Ulf M
UM