title: Enantioselective synthesis of vicinal halohydrins via dynamic kinetic resolution.
abstract: [reaction: see text] Expanding the scope of enantioselective catalysis via DKR, transfer hydrogenation of a variety of cyclic alpha-halo ketones was accomplished using the Noyori/Ikariya (R,R)- or (S,S)-I catalysts and either HCO(2)H/Et(3)N or HCO(2)Na/n-Bu(4)NBr in H(2)O/CH(2)Cl(2) as the hydrogen sources. Good yields of vicinal bromo-, chloro-, and fluorohydrins with excellent de and ee levels were achieved in most cases after a simple tuning of reaction conditions.
authors.affiliation: Instituto de Investigaciones Químicas, CSIC-USe, c/Américo, Seville, Spain.
authors.forename: Abel
authors.initials: A
authors.lastname: Ros
authors.forename: Antonio
authors.initials: A
authors.lastname: Magriz
authors.forename: Hansjörg
authors.initials: H
authors.lastname: Dietrich
authors.forename: Rosario
authors.initials: R
authors.lastname: Fernández
authors.forename: Eleuterio
authors.initials: E
authors.lastname: Alvarez
authors.forename: José M
authors.initials: JM
authors.lastname: Lassaletta