Positive selection can create false hotspots of recombination.
Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.
Reed
Floyd A
FA
Department of Biology, University of Maryland, College Park, Maryland 20742, USA. freed@umd.edu
Tishkoff
Sarah A
SA
D003198:Computer Simulation; D006801:Humans; D015810:Linkage Disequilibrium; D008540:Meiosis / Q000235:genetics; D008957:Models, Genetic; D011995:Recombination, Genetic; D012641:Selection, Genetic; D013045:Species Specificity