[Study on the anticancer activities of the Clematis manshrica saponins in vivo].
OBJECTIVE
To study the anticancer activity of the Clematis manshrica saponins in vivo.


METHODS
Anticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo.


RESULTS
The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25% (P < 0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P < 0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39% (P < 0.05-0.01), respectively.


CONCLUSIONS
The results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.
Zhao
Ying
Y
College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, China.
Wang
Chun-Mei
CM
Wang
Bao-Gui
BG
Zhang
Chong-Xi
CX
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D039324:Clematis / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D007941:Leukemia P388 / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012503:Saponins / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000473:pathology*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins