title: Total synthesis of ecteinascidin 743.
abstract: A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Jinchun
authors.initials: J
authors.lastname: Chen
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Chen
authors.forename: Michèle
authors.initials: M
authors.lastname: Bois-Choussy
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis; D004149:Dioxoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin; D014561:Urochordata / Q000737:chemistry
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004149:Dioxoles; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin