title: Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.
abstract: A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.
authors.affiliation: Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. kathleen.mortell@abbott.com
authors.forename: Kathleen H
authors.initials: KH
authors.lastname: Mortell
authors.forename: David J
authors.initials: DJ
authors.lastname: Anderson
authors.forename: James J
authors.initials: JJ
authors.lastname: Lynch
authors.forename: Sherry L
authors.initials: SL
authors.lastname: Nelson
authors.forename: Kathy
authors.initials: K
authors.lastname: Sarris
authors.forename: Heath
authors.initials: H
authors.lastname: McDonald
authors.forename: Reza
authors.initials: R
authors.lastname: Sabet
authors.forename: Scott
authors.initials: S
authors.lastname: Baker
authors.forename: Prisca
authors.initials: P
authors.lastname: Honore
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Lee
authors.forename: Michael F
authors.initials: MF
authors.lastname: Jarvis
authors.forename: Murali
authors.initials: M
authors.lastname: Gopalakrishnan
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D001554:Benzene / Q000737:chemistry; D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000494:pharmacology*; D015220:Calcium Channels / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy / Q000378:metabolism; D021122:Protein Subunits / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D008024:Ligands; D021122:Protein Subunits; D001554:Benzene