Expression of a chemorepellent factor, Slit2, in peripheral nerve regeneration.
The expression of mRNA for chemorepellent factors slit1 and slit2 in rat peripheral nerve regeneration was examined. The mRNA of slit2 increased when the continuity of basal lamina tubes was disrupted, not when it remained and the Slit2 protein was located in Schwann cells. These results suggest that disruption of the continuity of basal lamina tubes induces the expression of slit2 in Schwann cells during peripheral nerve regeneration.
Tanno
Toshihiko
T
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan.
Fujiwara
Ayumi
A
Takenaka
Shigeo
S
Kuwamura
Mitsuru
M
Tsuyama
Shingo
S
D000199:Actins / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D001369:Axons / Q000378:metabolism; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D010525:Peripheral Nerves / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D011971:Receptors, Immunologic / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012583:Schwann Cells / Q000378:metabolism; D012584:Sciatic Nerve / Q000293:injuries / Q000378:metabolism; D000097905:Roundabout Proteins; D000098552:Slit Homolog 2 Protein
D000199:Actins; D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; D000098552:Slit Homolog 2 Protein; C120010:Slit1 protein, mouse