title: Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration.
abstract: The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effect on NOR blood-brain barrier transport.
authors.affiliation: EA 3809, Faculté de Médecine et de Pharmacie, BP 199, Poitiers, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Marchand
authors.forename: Anna
authors.initials: A
authors.lastname: Forsell
authors.forename: Marylore
authors.initials: M
authors.lastname: Chenel
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Comets
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lamarche
authors.forename: William
authors.initials: W
authors.lastname: Couet
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects*; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D017551:Microdialysis; D009643:Norfloxacin / Q000493:pharmacokinetics*; D011339:Probenecid / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009643:Norfloxacin; D011339:Probenecid