From sequences to a functional unit.
Functional insights at the gene product level would help the drug discovery industry to effectively tap targets for therapeutics and biomedical applications. A complete functional unit can be multidomain, and it is the co-occurrence and interaction of these multiple domains that determine the function and functional diversity of their gene products. With at least 10% of genes from complete genomes existing in fused form, identifying gene fusion events helps us categorize the protein universe into distinct functional units with only sequence information.
Sivakumar
Ashwin
A
Institute of Biotechnology, Department of Genetics, University of Helsinki, Helsinki, Finland. ashwin.sivakumar@helsinki.fi
Wilton
Christopher
C
Holm
Liisa
L
D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D004926:Escherichia coli / Q000235:genetics; D019143:Evolution, Molecular; D050939:Gene Fusion; D006801:Humans; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D001426:Bacterial Proteins; D011506:Proteins