title: Impaired gastric motility and its relationship to gastrointestinal symptoms in patients with chronic renal failure.
abstract: BACKGROUND
  Gastrointestinal (GI) symptoms are common in patients with chronic renal failure (CRF), but the pathogenesis of these symptoms is unclear. Gastric motor function in CRF patients remains controversial, and the correlation between GI symptoms and gastric motility is also unclear. The aim of this study was to elucidate the relationship between gastric motility and GI symptoms in patients with CRF.
  
  
  METHODS
  Gastric motility was evaluated with cutaneously recorded electrogastrographs (EGGs) and gastric emptying of a solid meal, using 13C-octanoic acid breath testing, in 21 patients with predialysis endstage CRF and in 21 matched healthy controls. GI symptom severity was quantified in all patients.
  
  
  RESULTS
  The CRF patients had a significantly lower incidence of normogastria postprandially and a lower power ratio than did healthy controls on the EGGs, with the CRF patients showing delayed gastric emptying. Three patients with normal gastric motility had no GI symptoms, and ten patients with both abnormal EGG and delayed gastric emptying had significantly higher GI symptom scores than the patients without abnormalities.
  
  
  CONCLUSIONS
  The patients with CRF showed gastric hypomotility, including impaired gastric myoelectrical activity and delayed gastric emptying. Gastric hypomotility appears to be an important factor in the generation of GI symptoms in patients with CRF.
authors.affiliation: Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Nagoya 467-8601, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirako
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Naoko
authors.initials: N
authors.lastname: Misu
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Adachi
authors.forename: Michiko
authors.initials: M
authors.lastname: Shikano
authors.forename: Eriko
authors.initials: E
authors.lastname: Matsuhisa
authors.forename: Genjiro
authors.initials: G
authors.lastname: Kimura
mesh_terms: D000328:Adult; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male