Effect of marbofloxacin on cardiovascular variables in healthy isoflurane-anesthetized dogs.
OBJECTIVE
To study the hemodynamic effects of marbofloxacin (MBF) in isoflurane-anesthetized dogs.


METHODS
6 healthy 8-month-old Beagles.


METHODS
Anesthesia was induced with sodium thiopental and maintained with isoflurane. Cardiovascular variables were monitored throughout anesthesia. Marbofloxacin was administered by an IV bolus at 2 mg/kg, followed 10 minutes later by an infusion at a rate of 40 mg/kg/h for 30 minutes (total dose, 20 mg/kg). Plasma MBF concentrations were measured by high-performance liquid chromatography.


RESULTS
The mean peak concentration during MBF infusion was 34.2 +/- 6.4 microg/mL. The IV administration of the MBF bolus did not alter any cardiovascular variable in isoflurane-anesthetized dogs. Significant changes were found during infusion when a cumulative dose of 12 mg/kg had been given. The maximal decreases observed at the end of the infusion were 16% in heart rate, 26% in systolic left ventricular pressure, 33% in systolic aortic pressure, 38% in diastolic aortic pressure, 29% in cardiac output, and 12% in QT interval. All dogs recovered rapidly from anesthesia at the end of the experiment.


CONCLUSIONS
MBF may safely be used at 2 mg/kg IV in isoflurane-anesthetized dogs, and significant adverse cardiovascular effects are found only when 6 to 8 times the recommended dose is given.
Chanoit
Guillaume P
GP
UMR INRA Physiopathologie et Toxicologie Expérimentales, Ecole Vétérinaire de Toulouse, 31076 Toulouse Cedex, France.
Schneider
Marc
M
Woehrlé
Frédérique
F
Lefebvre
Hervé P
HP
D000704:Analysis of Variance; D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004285:Dogs / Q000502:physiology*; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous / Q000662:veterinary; D007530:Isoflurane; D015363:Quinolones / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects*
D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin; D007530:Isoflurane