title: Challenges and opportunities for pharmacoepidemiology in drug-therapy decision making.
abstract: Pharmacoepidemiology is a relatively new and evolving science that attempts to quantify mainly adverse drug events and patterns of drug use in a large population. The strength of pharmacoepidemiology over randomized trials is the ability to quantify rare adverse events that may occur over long periods. Recently, discordance in the results of pharmacoepidemiologic studies has made it difficult for clinicians and policy makers to make informed drug-therapy decisions. This commentary addresses the strength of pharmacoepidemiology and the advances in the methodology of pharmacoepidemiologic studies over the years. We also discuss the potential problem of discordant results and urge pharmacoepidemiologists to develop good practice guidelines for the conduct of pharmacoepidemiologic studies.
authors.affiliation: Center for Clinical Epidemiology and Evaluation, Vancouver Hosptial, 7th Floor, 828 West 10th Avenue, Vancouver, B.C., Canada. metminan@shaw.ca
authors.forename: Mahyar
authors.initials: M
authors.lastname: Etminan
authors.forename: Sudeep
authors.initials: S
authors.lastname: Gill
authors.forename: Mark
authors.initials: M
authors.lastname: Fitzgerald
authors.forename: Ali
authors.initials: A
authors.lastname: Samii
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D015982:Bias; D016022:Case-Control Studies; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects; D015340:Epidemiologic Research Design; D007783:Lactones / Q000009:adverse effects; D009203:Myocardial Infarction / Q000209:etiology; D010349:Patient Compliance; D017891:Pharmacoepidemiology / Q000379:methods / Q000639:trends; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D013450:Sulfones / Q000009:adverse effects; D013997:Time Factors
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib