Leukocytes in tubulointerstitial inflammation.
The work of Lange-Sperandio et al in this issue explores the differential role of beta2 integrins in promoting the macrophage infiltration characteristic of the obstructed kidneys of neonatal mice. Future work is needed to define factors that regulate macrophage death within or emigration from the kidney as well as to explore strategies to modulate macrophage phenotype. This knowledge will assist the development of novel therapeutic agents to limit injury and promote tissue repair.
Hughes
J
J
Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, UK. jeremy.hughes@ed.ac.uk
D000818:Animals; D007249:Inflammation / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology*; D007962:Leukocytes / Q000502:physiology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000502:physiology*; D016177:Macrophage-1 Antigen / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D051379:Mice
D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen