title: Synthesis and biological evaluation of simplified mycothiazole analogues.
abstract: Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L(4) larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity.
authors.affiliation: Departamento de Química Orgánica, Cátedra de Química Farmacéutica Facultad de Química, Universidad de la República, Montevideo, Uruguay.
authors.forename: Graciela
authors.initials: G
authors.lastname: Mahler
authors.forename: Gloria
authors.initials: G
authors.lastname: Serra
authors.forename: Sylvia
authors.initials: S
authors.lastname: Dematteis
authors.forename: Jenny
authors.initials: J
authors.lastname: Saldaña
authors.forename: Laura
authors.initials: L
authors.lastname: Domínguez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Manta
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D009559:Nippostrongylus / Q000187:drug effects; D010081:Oxazolone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000871:Anthelmintics; D013844:Thiazoles; C508681:mycothiazole; C461065:trifluoromethyloxazolinone; D010081:Oxazolone