title: APOA5 variant Ser19Trp influences a decrease of the total cholesterol in a male 8 year cohort.
abstract: OBJECTIVE
  To evaluate whether the relationship between dietary composition and plasma lipid levels is genetically determined.
  
  
  METHODS
  We have evaluated the influence of common apolipoprotein A5 (APOA5) variants (T-1131 > C, Ser19 > Trp and Val153 > Met) on plasma lipid concentrations in 117 males for whom dietary composition markedly changed and total cholesterol decreased (from 6.21 +/- 1.31 mmol/L in 1988 to 5.43 +/- 1.06 mmol/L in 1996) over an 8 year follow-up study.
  
  
  RESULTS
  APOA5 T-1131 > C and Val153 > Met variants did not influence the change in lipid measures over time. In Ser/Ser19 homozygotes, the plasma cholesterol was relatively stable over the years (6.1 +/- 1.2 mmol/L in 1988 and 5.6 +/- 1.0 mmol/L in 1996, -8%, P < 0.01). In contrast, in the Trp19 carriers, the decrease of the plasma cholesterol was more than 20% (6.5 +/- 1.6 mmol/L in 1988 and 5.1 +/- 1.0 mmol/L in 1996) (P < 0.001). The difference of the changes is significant (8% vs. 20%, P < 0.005). Changes in other analyzed lipid parameters have not been significantly associated with APOA5 variants.
  
  
  CONCLUSIONS
  Ser19 > Trp variant in the APOA5 gene may play an important role in an individual's sensitivity to dietary composition.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jaroslav.hubacek@medicon.cz
authors.forename: J A
authors.initials: JA
authors.lastname: Hubacek
authors.forename: Z
authors.initials: Z
authors.lastname: Skodová
authors.forename: V
authors.initials: V
authors.lastname: Adámková
authors.forename: V
authors.initials: V
authors.lastname: Lánská
authors.forename: J
authors.initials: J
authors.lastname: Pitha
mesh_terms: D000328:Adult; D000072040:Apolipoprotein A-V; D001053:Apolipoproteins / Q000235:genetics*; D001054:Apolipoproteins A; D002784:Cholesterol / Q000097:blood*; D015331:Cohort Studies; D018153:Czech Republic; D004032:Diet; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001053:Apolipoproteins; D001054:Apolipoproteins A; D002784:Cholesterol