title: Ring closing metathesis in the synthesis of biologically interesting peptidomimetics, sugars and alkaloids.
abstract: Olefin metathesis has rapidly established itself as an essential tool in the synthetic chemist's armoury. The ease of operation and functional group tolerance that is obtained with the modern generation of catalysts makes the use of metathesis an extremely attractive option when preparing medicinally interesting molecules. This article will outline some of the ways in which chemists from both industry and academia have been utilising and developing metathesis in the search for novel biological probes and drug leads.
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 135, D-10623 Berlin, Germany.
authors.forename: William H C
authors.initials: WH
authors.lastname: Martin
authors.forename: Siegfried
authors.initials: S
authors.lastname: Blechert
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D002241:Carbohydrates; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D010456:Peptides, Cyclic; D012428:Ruthenium; D008982:Molybdenum