title: In vitro elution of vancomycin from calcium phosphate cement.
abstract: Antibiotic-impregnated bone cement beads have become popular for the treatment of osteomyelitis and/or prosthesis infection. However, bone cement has the disadvantage of heating up during polymerization of cement. Recently, calcium phosphate cement (CPC) has been used as a bone replacement and augmentation, and it does not heat up during polymerization. First, we measured the release rate of vancomycin (VCM) from bone cement and CPC impregnated with VCM for 2 weeks in vitro. The mean concentration of VCM for CPC was 62.6 times at 7 days (258 +/- 29 vs 4.12 +/- 1.0) and 6.7 times at 13 days (15.5 +/- 5.5 vs 2.3 +/- 0.7). Second, we were successful in treating 2 cases of osteomyelitis and prosthesis infection with VCM-impregnated CPC. From this study, we concluded that VCM-impregnated CPC might be an effective material for the treatment of osteomyelitis and/or prosthesis infection.
authors.affiliation: Department of Orthopaedic Surgery, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Katano
authors.forename: Akira
authors.initials: A
authors.lastname: Nagumo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Toh
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D001843:Bone Cements; D002130:Calcium Phosphates; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D066298:In Vitro Techniques; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D002130:Calcium Phosphates; D014640:Vancomycin