title: Statistical voxel-wise analysis of ictal SPECT reveals pattern of abnormal perfusion in patients with temporal lobe epilepsy.
abstract: OBJECTIVE
  To investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion SPECT images (BSI) from patients with temporal lobe epilepsy (TLE).
  
  
  METHODS
  It was acquired interictal and ictal BSI from 24 patients with refractory TLE. BSIs were analyzed by visual inspection and statistical parametric mapping (SPM2). Statistical analysis compared the patients group to a control group of 50 volunteers. The images from patients with left-TLE were left-right flipped.
  
  
  RESULTS
  It was not observed significant perfusional differences in interictal scans with SPM. Ictal BSI in SPM analysis revealed hyperperfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipital region, ipsilateral posterior cingulate gyrus, occipital lobes and ipsilateral basal ganglia. Ictal BSI also showed areas of hypoperfusion.
  
  
  CONCLUSIONS
  In a group analysis of ictal BSI of patients with TLE, voxel-wise analysis detects a network of distant regions of perfusional alteration which may play active role in seizure genesis and propagation.
authors.affiliation: Department of Radiology, Faculdade de Ciências Médicas, UNICAMP, Campinas, Brazil. juarezbarbara@hotmail.com
authors.forename: Bárbara Juarez
authors.initials: BJ
authors.lastname: Amorim
authors.forename: Elba Cristina Sá de Camargo
authors.initials: EC
authors.lastname: Etchebehere
authors.forename: Edwaldo Eduardo
authors.initials: EE
authors.lastname: Camargo
authors.forename: Pablo Augusto
authors.initials: PA
authors.lastname: Rio
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bonilha
authors.forename: Chris
authors.initials: C
authors.lastname: Rorden
authors.forename: Li Min
authors.initials: LM
authors.lastname: Li
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003627:Data Interpretation, Statistical; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon