title: Detection of von Willebrand factor and tissue factor in platelets-fibrin rich coronary thrombi in acute myocardial infarction.
abstract: The rapid closure of coronary arteries due to occlusive thrombi is the major cause of acute myocardial infarction. However, the mechanisms of coronary thrombus formation have not been elucidated. We immunohistochemically assessed the localizations and their changes over time of glycoprotein IIb/IIIa, fibrin, von Willebrand factor (vWF), and tissue factor (TF), after the onset of chest pain (<4, 4 to 6, or 6 to 12 hours), in fresh coronary thrombi causing acute myocardial infarction. The occlusive thrombi were consistently composed of platelets, fibrin, vWF, and TF from the early phase of onset, and glycoprotein IIb/IIIa and fibrin were closely associated with vWF and TF, respectively. vWF and/or TF may contribute to occlusive thrombus formation and be novel therapeutic candidates for treating patients with coronary thrombosis.
authors.affiliation: Department of Pathology, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamashita
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sumi
authors.forename: Shinya
authors.initials: S
authors.lastname: Goto
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Hoshiba
authors.forename: Kensaku
authors.initials: K
authors.lastname: Nishihira
authors.forename: Riichirou
authors.initials: R
authors.lastname: Kawamoto
authors.forename: Kinta
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Date
authors.forename: Takuroh
authors.initials: T
authors.lastname: Imamura
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Asada
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D003328:Coronary Thrombosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014841:von Willebrand Factor; D005337:Fibrin; D013925:Thromboplastin