title: Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila melanogaster.
abstract: Previously we described highly unstable mutations in the yellow locus, induced by the chimeric element and consisting of sequences from a distally located 1A unique genomic region, flanked by identical copies of an internally deleted 1.2-kb P element. Here we show that a sequence, which is part of the yellow 1A region, can be transmitted to the AS-C by successive inversion and reinversion generated by yellow- and AS-C-located P elements. The chimeric element contains a regulatory element from the 1A region that specifically blocks yellow wing and body enhancers and simultaneously stimulates yellow expression in bristles. These results suggest that P-element-generated chimeric elements may play a certain role in rapid changes of regulatory regions of genes during evolution.
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Pomerantseva
authors.forename: Inna
authors.initials: I
authors.lastname: Biryukova
authors.forename: Rita
authors.initials: R
authors.lastname: Silicheva
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Savitskaya
authors.forename: Anton
authors.initials: A
authors.lastname: Golovnin
authors.forename: Pavel
authors.initials: P
authors.lastname: Georgiev
mesh_terms: D000483:Alleles; D000818:Animals; D004247:DNA / Q000378:metabolism; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D019143:Evolution, Molecular; D018095:Germ-Line Mutation; D019476:Insect Proteins; D008957:Models, Genetic; D016254:Mutagenesis, Insertional; D010641:Phenotype; D011993:Recombinant Fusion Proteins / Q000737:chemistry; D012045:Regulatory Sequences, Nucleic Acid; D015183:Restriction Mapping
chemical_list: D004251:DNA Transposable Elements; D019476:Insect Proteins; D011993:Recombinant Fusion Proteins; D004247:DNA