CyNodal, the Japanese newt nodal-related gene, is expressed in the left side of the lateral plate mesoderm and diencephalon.
The nodal and nodal-related genes play fundamental roles during deuterostome left-right axis formation. Several of these genes show left-sided expression in the lateral plate mesoderm and brain region. We have isolated the nodal-related gene, CyNodal, from Cynops pyrrhogaster. CyNodal mRNA is detected at the marginal zone and left side of several tissues. The left-sideness of CyNodal mRNA expression is highly conserved throughout vertebrate evolution. However, CyNodal mRNA expression shows little variation from the Xenopus nodal-related gene 1, in that CyNodal gene expression in the left lateral plate mesoderm shifts from posterior to anterior at least twice.
Ito
Yuzuru
Y
International Cooperative Research Program (ICORP), Japan Science and Technology Agency (JST), Japan.
Oinuma
Tsutomu
T
Takano
Kazuhiro
K
Komazaki
Shinji
S
Obata
Shuichi
S
Asashima
Makoto
M
D000595:Amino Acid Sequence; D000818:Animals; D019521:Body Patterning / Q000235:genetics* / Q000502:physiology; D017124:Conserved Sequence; D003545:Cysteine / Q000737:chemistry; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D004027:Diencephalon / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D019143:Evolution, Molecular; D005260:Female; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008648:Mesoderm / Q000378:metabolism*; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D012455:Salamandridae / Q000196:embryology / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013194:Staining and Labeling
D018076:DNA, Complementary; D011506:Proteins; D003545:Cysteine