title: The radon inverse dose rate effect and high-LET galactic hazards.
abstract: The lung dose rate per unit 222Rn concentration in enclosed spaces is shown to experience transitions at high radon concentrations. This has implications on the radon inverse dose rate effect. At an air change rate (ACH) of 0.194 h(-1) and relative humidity (RH) of 52.3% in a 0.283 m3 test chamber, the total human lung dose for an adult male in a residential setting (breathing rate 0.78 m3 h(-1)) would undergo a reduction of 2.5 using the ICRP 66 human respiratory tract model and the BEIR VI methodology. Using the same methodology of both Cross (Pacific Northwest Laboratory rat exposures) and Lubin et al. (miners dose rates), adjustments are necessary for effects of RH and ACHs. These adjustments, however, do not affect the reduction behaviour. It is thus shown that the enhanced deposition effect (EDE) must influence the magnitude of the purported inverse dose rate effect (IDRE). In the analysis of animal data, Cross rat exposures in a 2.0 m3 chamber, a reduction in lung dose is estimated to be over a factor of 3 the transition between the 50 and 500 WLM week(-1) dose rate range. For an estimation of the EDE, using a hypothetical 30 m3 enclosure for underground miners, we obtain a factor of approximately 4 in human lung dose reduction. Although the extensive analyses required make these results qualitative, the EDE behaviour is sufficiently conclusive that these estimates show that the radon IDRE for lung cancer must be an EDE dosimetric issue as well as a radiological lung cell dose response issue. The consequence of analysis of other animal data would achieve the same conclusion.
authors.affiliation: International Academy, 693 Wellerburn Road, Severna Park, MD 21146, USA. VFLeonard@worldnet.att.net
authors.forename: Bobby E
authors.initials: BE
authors.lastname: Leonard
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000493:pharmacokinetics; D016902:Air Pollution, Indoor / Q000032:analysis*; D003198:Computer Simulation; D004781:Environmental Exposure / Q000032:analysis; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D011835:Radiation Protection / Q000379:methods*; D017687:Radon Daughters / Q000032:analysis* / Q000493:pharmacokinetics*; D018570:Risk Assessment / Q000379:methods*
chemical_list: D000393:Air Pollutants; D017687:Radon Daughters