[A case-control study on the mxA polymorphisms and susceptibility to severe acute respiratory syndromes].
OBJECTIVE
To investigate the association between the genetic polymorphisms of myxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes (SARS).


METHODS
A case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the T/G polymorphism at position-88 in the mxA gene promoter. Information on related factors of SARS was collected using a pre-testing questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.


RESULTS
Sixty-six cases and sixty-four controls were selected for the study. Comparing with GG genotype, the proportion of GT genotype were significantly higher in the case group (81.3%) than that in the control group (62.5%)) with an OR (95% CI) of 2.700 (1.208-6.037). Multivariate logistic regression analysis revealed that the significant association remained after factors as wearing masks, protection gowns and eye-protection when contacting with SARS patient etc. were adjusted with an OR (95 % CI) of 2.911 (1.027-8.250).


CONCLUSIONS
mxA promoter-88G/T SNP might be confered to host genetic susceptibility to SARS in Chinese Han population.
Wang
Hong-wei
HW
Epidemiological Department of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
He
Jing
J
Zhang
Pan-he
PH
Tang
Fang
F
Wang
Tian-bao
TB
Luan
Yi-he
YH
Lv
Hui
H
Cao
Zhao-yang
ZY
Wu
Xiao-ming
XM
Zhao
Qiu-min
QM
Liu
Wei
W
Cao
Wu-chun
WC
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D064547:Myxovirus Resistance Proteins; D011110:Polymorphism, Genetic; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics*
C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins