Synthesis of the tetracyclic core of the kempanes by a ring-closing metathesis strategy.
[reaction: see text] The synthesis of the tetracyclic ring system of the kempane diterpenes was achieved through the highly regio- and stereoselective Diels-Alder reaction of an isopropenyl-diene with 2,6-dimethyl-p-benzoquinone, addition of an allyl group, and ring-closing metathesis of the isopropenyl and allyl groups.
Zhao
Liang
L
Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada.
Burnell
D Jean
DJ