Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture.
Geniposide from Gardenia jasminoides protected neuronal cells from damage in oxygen and glucose deprivation-exposed hippocampal slice culture. Geniposide showed a greater protective effect on the granule cell layer than on the pyramidal cell layer including CA 1 and CA 3. On the basis of the experimental results, geniposide may be a therapeutic agent for ischemia in patients.
Lee
Pyeongjae
P
Department of Agricultural Biology, National Institute of Agricultural Science and Technology, Korea.
Lee
Jongseok
J
Choi
Sang Yoon
SY
Lee
Sang Eun
SE
Lee
Sanghyun
S
Son
Dongwook
D
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D032062:Gardenia / Q000737:chemistry*; D005947:Glucose / Q000172:deficiency*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D000860:Hypoxia / Q000473:pathology*; D039823:Iridoids / Q000302:isolation & purification / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D009924:Organ Culture Techniques; D017966:Pyramidal Cells / Q000187:drug effects; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D039823:Iridoids; D011714:Pyrans; C007835:geniposide; D005947:Glucose