Is double renal transplantation a risk factor for cytomegalovirus disease?
We performed a retrospective study to identify the risk factors for cytomegalovirus (CMV) disease among 570 renal transplant recipients. By means of a multivariate analysis we identified antilymphocyte antibody therapy (odds ratio [OR]: 4.6; 95% confidence interval [CI]: 2.0 to 10.6), high doses of corticosteroids (OR: 3.4; 95% CI: 1.2 to 10.1), and double renal transplant (OR: 4.1; 95% CI: 1.5 to 11.5). To the best of our knowledge, this is the first study to suggest that in addition to other well-known risk factors for CMV disease (ie, therapy with anti-lymphocyte antibodies or high doses of corticosteroids), the use of double renal transplantation appears to increase the risk of CMV disease in this population.
Moreno-Cuerda
V J
VJ
Infectious Diseases Unit and Nephrology Department, University Hospital 12 de Octubre, Madrid, Spain.
Aguado
J M
JM
Morales
M
M
Andrés
A
A
Morales
J M
JM
López-Medrano
F
F
San Juan
R
R
Lumbreras
C
C
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D000961:Antilymphocyte Serum / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000821:virology*; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data
D000305:Adrenal Cortex Hormones; D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents