Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration.
The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effect on NOR blood-brain barrier transport.
Marchand
Sandrine
S
EA 3809, Faculté de Médecine et de Pharmacie, BP 199, Poitiers, France.
Forsell
Anna
A
Chenel
Marylore
M
Comets
Emmanuelle
E
Lamarche
Isabelle
I
Couet
William
W
D000818:Animals; D001692:Biological Transport / Q000187:drug effects*; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D017551:Microdialysis; D009643:Norfloxacin / Q000493:pharmacokinetics*; D011339:Probenecid / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009643:Norfloxacin; D011339:Probenecid