title: Death of an infant involving benzocaine.
abstract: This report describes the death of a four-month-old Hispanic male which may be related to benzocaine toxicity. A toxicological evaluation revealed benzocaine at a concentration of 3.48 mg/L, and postmortem methemoglobin of 36% (normal 0.4-1.5). Methemoglobinemia is a complication of benzocaine toxicity. In light of the toxicology findings, the coroner investigated the source of the benzocaine and discovered that the child was treated with Zenith Goldline Allergen Ear Drops containing 0.25% w/v benzocaine and 5.4% w/v antipyrine. There was an admission by a caregiver that on the day prior to the child's death, he had been treated with three times the prescribed dose. Blood benzocaine concentrations in nine other unrelated cases were determined and concentrations ranged from <0.05-5.3 mg/L (mean 1.48 mg/L). Seven of the nine cases were positive for drugs of abuse, and one additional case was described as a known drug user. Methemoglobin in these benzocaine positive cases ranged from 6-69%; however, methemoglobin concentrations in postmortem cases are frequently elevated and should be interpreted with caution. The unknown significance of the benzocaine, and the circumstances of the case raise questions about the ultimate attribution of this death to SIDS.
authors.affiliation: Washington State Toxicology Laboratory, Forensic Laboratory Services Bureau, Seattle 98134, USA. barry.logan@wsp.wa.gov
authors.forename: Barry K
authors.initials: BK
authors.lastname: Logan
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Gordon
mesh_terms: D000779:Anesthetics, Local / Q000097:blood*; D001566:Benzocaine / Q000097:blood*; D017248:Enzyme Multiplied Immunoassay Technique; D005554:Forensic Medicine; D006801:Humans; D007223:Infant; D008297:Male; D008708:Methemoglobinemia / Q000175:diagnosis*; D013398:Sudden Infant Death
chemical_list: D000779:Anesthetics, Local; D001566:Benzocaine