title: Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions.
abstract: OBJECTIVE
  Although evidence on elevated creatine phosphokinase (CPK) as a tool for the diagnosis of ectopic pregnancy (EP) is rather conflictive, no previous study on CPK isoenzyme levels and their relative ratio was found in the literature.
  
  
  METHODS
  Forty women with EP, 20 with intrauterine (IU) abortive gestation, and 20 regular pregnant women (controls) were studied. Serum total CPK, CPK-MB, and CPK-MM levels were measured at the time of presentation and 24 hours after surgery. Relative operating characteristic (ROC) curves were plotted.
  
  
  RESULTS
  Women with EP had significantly higher CPK concentrations and a significantly decreased CPK-MB relative ratio (CPK-MB%), compared with both women with IU abortive pregnancy and controls. The ROC curves demonstrated a significant discriminatory ability of both increased total CPK and decreased CPK-MB% ratio for the diagnosis of EP.
  
  
  CONCLUSIONS
  Determination of CPK isoenzyme fractions can significantly enhance the diagnostic value of total maternal CPK in the prediction of ectopic pregnancy.
authors.affiliation: Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Ilias
authors.initials: I
authors.lastname: Katsikis
authors.forename: David
authors.initials: D
authors.lastname: Rousso
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Farmakiotis
authors.forename: Anargyros
authors.initials: A
authors.lastname: Kourtis
authors.forename: Evanthia
authors.initials: E
authors.lastname: Diamanti-Kandarakis
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Zournatzi-Koiou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Panidis
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood*; D052283:Creatine Kinase, MM Form / Q000097:blood*; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000097:blood; D011271:Pregnancy, Ectopic / Q000097:blood* / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D052283:Creatine Kinase, MM Form