title: Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.
abstract: The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p13.2 (LOD=3.39) and suggestive evidence of linkage to 14q11.2 (LOD=2.87), 14q11.2-q13.2 (LOD=2.33), and 20p12.1-p11.2 (LOD=2.33). Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study--which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent--indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.
authors.affiliation: Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki-ken, 305-8577, Japan. tarinami@md.tsukuba.ac.jp
authors.forename: Tadao
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authors.lastname: Arinami
authors.forename: Tsuyuka
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authors.lastname: Ohtsuki
authors.forename: Hiroki
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authors.lastname: Ishiguro
authors.forename: Hiroshi
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authors.lastname: Ujike
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authors.forename: Yukitaka
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authors.lastname: Shibuya
authors.forename: Kenshiro
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authors.lastname: Suzuki
authors.forename: Tatsuyuki
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authors.lastname: Muratake
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authors.lastname: Kaneko
authors.forename: Toshiyuki
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authors.lastname: Someya
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authors.lastname: Inada
authors.forename: Takeo
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authors.forename: Takuya
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authors.lastname: Kojima
authors.forename: Sakae
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authors.lastname: Takahashi
authors.forename: Ohmori
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authors.lastname: Shinkai
authors.forename: Michiko
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authors.lastname: Nakamura
authors.forename: Hiroshi
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authors.lastname: Fukuzako
authors.forename: Tomo
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authors.lastname: Hashiguchi
authors.forename: Shin-ich
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authors.lastname: Niwa
authors.forename: Takuya
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authors.lastname: Ueno
authors.forename: Hirokazu
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authors.lastname: Tachikawa
authors.forename: Takafumi
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authors.lastname: Hori
authors.forename: Takashi
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authors.lastname: Asada
authors.forename: Shinichiro
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authors.lastname: Nanko
authors.forename: Hiroshi
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authors.lastname: Kunugi
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Norio
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authors.lastname: Ozaki
authors.forename: Nakao
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authors.lastname: Iwata
authors.forename: Mutsuo
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authors.lastname: Harano
authors.forename: Heii
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authors.lastname: Arai
authors.forename: Tohru
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authors.lastname: Ohnuma
authors.forename: Ichiro
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authors.lastname: Kusumi
authors.forename: Tsukasa
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authors.lastname: Koyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoneda
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fukumaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shibata
authors.forename: Sunao
authors.initials: S
authors.lastname: Kaneko
authors.forename: Hisashi
authors.initials: H
authors.lastname: Higuchi
authors.forename: Norio
authors.initials: N
authors.lastname: Yasui-Furukori
authors.forename: Yohtaro
authors.initials: Y
authors.lastname: Numachi
authors.forename: Masanari
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authors.lastname: Itokawa
authors.forename: Yuji
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authors.lastname: Okazaki
mesh_terms: D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002890:Chromosomes, Human, Pair 20; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008126:Lod Score; D018895:Microsatellite Repeats; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D035781:Siblings
chemical_list: D005819:Genetic Markers