title: Treatment of Guillain-Barré syndrome induced by cyclosporine in a lung transplant patient.
abstract: We report the case of a 58-year-old man with severe chronic obstructive pulmonary disease who developed acute quadriparesis during the post-operative period following bilateral lung transplantation after receiving cyclosporine for immunosuppression. Electromyography with nerve conduction study and cerebrospinal fluid analysis supported a diagnosis of Guillain-Barré Syndrome, which improved upon the discontinuation of cyclosporine, replacement with tacrolimus, and initiation of plasmapheresis. We propose the discontinuation of cyclosporine and initiation of plasmapheresis as a treatment for cyclosporine-associated Guillain-Barré syndrome.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA. jfalk@usc.edu
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Falk
authors.forename: Francis C
authors.initials: FC
authors.lastname: Cordova
authors.forename: Anca
authors.initials: A
authors.lastname: Popescu
authors.forename: Gabriel
authors.initials: G
authors.lastname: Tatarian
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: Criner
mesh_terms: D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D020275:Guillain-Barre Syndrome / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine