The mitochondria and insulin release: Nnt just a passing relationship.
Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, demonstrate that Nnt in pancreatic beta cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.
Remedi
M S
MS
The Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nichols
C G
CG
Koster
J C
JC
D000818:Animals; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000201:enzymology*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000502:physiology*; D009250:NADP Transhydrogenases / Q000235:genetics / Q000502:physiology*
D007328:Insulin; D024101:Mitochondrial Proteins; D009250:NADP Transhydrogenases