title: Clinical variables at age 2 predictive of mental retardation at age 5 in children with pervasive developmental disorder.
abstract: This study attempted to find clinical variables evaluated at age 2 that would predict mental retardation (MR, IQ/cognition-adaptation developmental quotient [C-A DQ]<70) at age 5 in 57 children with pervasive developmental disorder (PDD). About two-thirds of subjects had MR at both initial and outcome evaluations. The C-A DQ at initial evaluation was significantly lower in mentally retarded PDD (MRPDD) than in high-functioning (IQ >or= 70) PDD (HFPDD). MRPDD changed less than HFPDD in IQ/C-A DQ between ages 2 and 5. The C-A DQ at age 2 was a potent predictor for MR at age 5 and the total score and three item scores of Childhood Autism Rating Scale-Tokyo Version evaluated at age 2 were also useful in predicting MR at age 5.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. t-tak@umin.ac.jp
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Takeda
authors.forename: Tomonori
authors.initials: T
authors.lastname: Koyama
authors.forename: Chieko
authors.initials: C
authors.lastname: Kanai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurita
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis / Q000523:psychology; D002659:Child Development Disorders, Pervasive / Q000523:psychology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis* / Q000523:psychology*; D007361:Intelligence Tests; D007804:Language Development; D008297:Male; D011237:Predictive Value of Tests; D011581:Psychological Tests; D013060:Speech / Q000502:physiology