title: Phosphodiesterase 11: a brief review of structure, expression and function.
abstract: Phosphodiesterase 11 (PDE11) is the latest isoform of the phosphodiesterase family to be identified. Interest in PDE11 has increased recently because tadalafil, an oral phosphodiesterase 5 inhibitor, cross reacts with PDE11. The function of PDE11 remains largely unknown, but growing evidence points to a possible role in male reproduction. The published literature on PDE11 structure, function and expression is reviewed.
authors.affiliation: Department of Urology, University of Illinois at Chicago, Chicago, IL 60612-7316, USA. tonymakhlouf@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Makhlouf
authors.forename: A
authors.initials: A
authors.lastname: Kshirsagar
authors.forename: C
authors.initials: C
authors.lastname: Niederberger
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction / Q000502:physiology
chemical_list: D010727:Phosphoric Diester Hydrolases