title: Enhancement of antitumor effect of paclitaxel in combination with immunomodulatory Withania somnifera on benzo(a)pyrene induced experimental lung cancer.
abstract: The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. In our previous study, we reported the antioxidant and anticarcinogenic effect of W. somnifera (L.) Dunal along with paclitaxel. Immune dysfunction has been found to be associated with cancer and chemotherapy. Benzo(a)pyrene induced cancer animals were treated with 400mg/kg bodyweight of W. somnifera (L.) Dunal extract for 30 days significantly alters the levels of immunocompetent cells, immune complexes and immunoglobulins. Based on the data, the carcinogen as well as the paclitaxel affects the immune system, the toxic side effects on the immune system is more reversible and more controllable by W. somnifera (L.) Dunal. These results concluded the immunomodulatory activity of W. somnifera (L.) Dunal extract, which is a known immunomodulator in indigenous medicine.
authors.affiliation: Department of Medical Biochemistry, Dr. ALM Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India. senthilnpm@rediffmail.com
authors.forename: Palaniyandi
authors.initials: P
authors.lastname: Senthilnathan
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Padmavathi
authors.forename: Syed Mumtaz
authors.initials: SM
authors.lastname: Banu
authors.forename: Dhanapal
authors.initials: D
authors.lastname: Sakthisekaran
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000276:immunology / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001564:Benzo(a)pyrene / Q000494:pharmacology*; D004195:Disease Models, Animal; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007155:Immunologic Factors / Q000276:immunology / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D017239:Paclitaxel / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000276:immunology / Q000494:pharmacology*; D032341:Withania / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007136:Immunoglobulins; D007155:Immunologic Factors; D010936:Plant Extracts; D001564:Benzo(a)pyrene; D017239:Paclitaxel