title: Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia.
abstract: To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N=186), frontotemporal dementia (FTD) (N=29), mixed dementia (MXD) (N=28), dementia with Lewy bodies (DLB) (N=11) and Parkinson's disease dementia (PDD) (N=7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)). In FTD patients, we identified dose dependent effects of APOE epsilon4 on the Behave-AD total and cluster aggressiveness scores. APOE epsilon2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD patients were found. In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon4 with aggression (FTD) and of APOE epsilon2 with delusions (PDD/DLB).
authors.affiliation: Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium.
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Engelborghs
authors.forename: Bart
authors.initials: B
authors.lastname: Dermaut
authors.forename: Peter
authors.initials: P
authors.lastname: Mariën
authors.forename: Anoek
authors.initials: A
authors.lastname: Symons
authors.forename: Ellen
authors.initials: E
authors.lastname: Vloeberghs
authors.forename: Karen
authors.initials: K
authors.lastname: Maertens
authors.forename: Nore
authors.initials: N
authors.lastname: Somers
authors.forename: Johan
authors.initials: J
authors.lastname: Goeman
authors.forename: Rosa
authors.initials: R
authors.lastname: Rademakers
authors.forename: Marleen
authors.initials: M
authors.lastname: Van den Broeck
authors.forename: Barbara
authors.initials: B
authors.lastname: Pickut
authors.forename: Marc
authors.initials: M
authors.lastname: Cruts
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Peter P
authors.initials: PP
authors.lastname: De Deyn
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics / Q000473:pathology; D000704:Analysis of Variance; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001526:Behavioral Symptoms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D003704:Dementia / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D003710:Demography; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D008875:Middle Aged
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E