title: Pars plana vitrectomy with and without peeling of the inner limiting membrane for diabetic macular edema.
abstract: OBJECTIVE
  A prospective, comparative, nonrandomized study to evaluate the efficacy of pars plana vitrectomy (PPV) with and without inner limiting membrane (ILM) peeling for persistent diffuse clinically significant macular edema.
  
  
  METHODS
  Eighteen patients with persistent diffuse clinically significant macular edema despite laser photocoagulation were recruited for the study. Clinical assessment included determination of best-corrected visual acuity, fundus fluorescein angiography, optical coherence tomography, and perifoveal cone function testing. Eight patients underwent PPV with elevation and removal of the posterior hyaloid alone, and 10 patients underwent vitrectomy and ILM peeling. The follow-up was 12 months.
  
  
  RESULTS
  Patients with ILM peeling had improvement in foveal thickness (P = 0.07) and significant improvement in the macular volume (P = 0.039) 12 months after surgery but did not have significant improvement in Early Treatment Diabetic Retinopathy Study vision or perifoveal cone function. There was no significant difference in outcome parameters between the no peeling group and the ILM peeling group.
  
  
  CONCLUSIONS
  In this prospective, comparative study of PPV with and without ILM peeling for diffuse clinically significant macular edema, structural improvement was seen but with limited visual improvement after ILM peeling.
authors.affiliation: Moorfields Eye Hospital, London, UK.
authors.forename: Jignesh I
authors.initials: JI
authors.lastname: Patel
authors.forename: Phillip G
authors.initials: PG
authors.lastname: Hykin
authors.forename: Markus
authors.initials: M
authors.lastname: Schadt
authors.forename: Vy
authors.initials: V
authors.lastname: Luong
authors.forename: Fred
authors.initials: F
authors.lastname: Fitzke
authors.forename: Zdenek J
authors.initials: ZJ
authors.lastname: Gregor
mesh_terms: D000328:Adult; D000368:Aged; D001485:Basement Membrane / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003930:Diabetic Retinopathy / Q000503:physiopathology / Q000601:surgery*; D019773:Epiretinal Membrane / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008269:Macular Edema / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013459:Sulfur Hexafluoride / Q000627:therapeutic use; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy / Q000379:methods*
chemical_list: D013459:Sulfur Hexafluoride