title: The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression.
abstract: The heterogeneous nuclear ribonucleoproteins (hnRNP) are a family of proteins which share common structural domains, and extensive research has shown that they have central roles in DNA repair, telomere biogenesis, cell signaling and in regulating gene expression at both transcriptional and translational levels. Through these key cellular functions, individual hnRNPs have a variety of potential roles in tumour development and progression including the inhibition of apoptosis, angiogenesis and cell invasion. The aims of this review are to provide an overview of the multi functional roles of the hnRNPs, and how such roles implicate this family as regulators of tumour development. The different stages of tumour development that are potentially regulated by the hnRNPs along with their aberrant expression profiles in tumour tissues will also be discussed.
authors.affiliation: Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
authors.forename: Brian
authors.initials: B
authors.lastname: Carpenter
authors.forename: Catriona
authors.initials: C
authors.lastname: MacKay
authors.forename: Ayham
authors.initials: A
authors.lastname: Alnabulsi
authors.forename: Morven
authors.initials: M
authors.lastname: MacKay
authors.forename: Colin
authors.initials: C
authors.lastname: Telfer
authors.forename: William T
authors.initials: WT
authors.lastname: Melvin
authors.forename: Graeme I
authors.initials: GI
authors.lastname: Murray
mesh_terms: D000818:Animals; D018450:Disease Progression; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000378:metabolism
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D019098:Telomerase