Which Doppler parameters are load independent? A study in normal volunteers after blood donation.
OBJECTIVE
We sought to assess the effects of blood donation on different echocardiographic parameters in healthy volunteers.


METHODS
A total of 101 healthy male volunteers were evaluated by echocardiography before and immediately after a 500-mL blood donation. In addition to traditional Doppler indices of left ventricular filling, Doppler tissue, color flow propagation, strain (epsilon), and epsilon rate were measured.


RESULTS
There was a statistically significant decrease in mitral peak E and A values after blood donation (E wave 0.85 +/- 0.12 vs 0.79 +/- 0.14 cm/s, P = .01; A wave 0.65 +/- 0.10 vs 0.60 +/- 0.12 cm/s, P = .05). Mitral color flow propagation velocity was not affected (560 +/- 123 vs 571 +/- 132 mm/s, P = not significant). There were no significant differences in the Doppler tissue parameters of peak systolic, and early and late diastolic velocities after blood donation (Sm 13.5 +/- 4.6 vs 13.3 +/- 4.9 cm/s, P = not significant; Em 15.5 +/- 4.9 vs 15.9 +/- 5.1 cm/s, P = not significant; and Am 14.1 +/- 3.9 vs 14.1 +/- 3.5 cm/s, P = not significant, respectively). The peak systolic decreased significantly (-28 +/- 8% vs -21 +/- 4%, P = .03) whereas the peak systolic rate was not affected (1.5 +/- 0.35 vs 1.4 +/- 0.40 s(-1), P = not significant).


CONCLUSIONS
In healthy male volunteers, preload reduction induced by a 500-mL blood donation does not affect the color propagation velocity, rate, and Doppler tissue velocities.
Abali
Gülcan
G
Hacettepe University, Ankara, Turkey. gulcanabali@yahoo.com
Tokgözoğlu
Lale
L
Ozcebe
Osman Ilhami
OI
Aytemir
Kudret
K
Nazli
Nasih
N
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013318:Stroke Volume / Q000502:physiology*; D014463:Ultrasonography; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*