Growth hormone and its disorders.
Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting postnatal longitudinal growth as well as protein, lipid, and carbohydrate metabolism. GH hypersecretion results in gigantism or acromegaly, a condition associated with significant morbidity and mortality, while GH deficiency results in growth retardation in children and the GH deficiency syndrome in adults. This article, aimed at non-paediatric physicians, examines the clinical features, diagnosis, and current concepts in the management of these conditions.
Ayuk
J
J
Division of Medical Sciences, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK. j.ayuk@bham.ac.uk
Sheppard
M C
MC
D000172:Acromegaly / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D018491:Dopamine Agonists / Q000627:therapeutic use; D006130:Growth Disorders / Q000209:etiology* / Q000628:therapy; D013006:Growth Hormone / Q000172:deficiency* / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D011986:Receptors, Somatotropin / Q000037:antagonists & inhibitors; D012017:Referral and Consultation; D013004:Somatostatin / Q000031:analogs & derivatives
D018491:Dopamine Agonists; D011986:Receptors, Somatotropin; D013004:Somatostatin; D013006:Growth Hormone