title: Caffeic acid inhibits compound 48/80-induced allergic symptoms in mice.
abstract: The effect of caffeic acid on scratching behavior and vascular permeability changes induced by compound 48/80 in ICR mice were investigated. An oral dose of 500 mg/kg of caffeic acid significantly inhibited scratching behavior and vascular permeability induced by compound 48/80. The inhibitory effects of daily administration of lower doses of caffeic acid, 100 and 200 mg/kg, were also investigated; and it was found that 200 mg/kg significantly inhibited compound 48/80-induced scratching behavior after the second week of consecutive administration. The effect of 200 mg/kg of caffeic acid on scratching behavior was observed up to the third week of the treatment. The decrease in histamine content induced by compound 48/80 was significantly antagonized by 200 mg/kg. The findings suggest that caffeic acid may be effective for treating itch and edema in allergic dermatitis.
authors.affiliation: Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Maria Alejandra
authors.initials: MA
authors.lastname: Hossen
authors.forename: Toshio
authors.initials: T
authors.lastname: Inoue
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Shinmei
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Minami
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujii
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002109:Caffeic Acids / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006967:Hypersensitivity / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D016877:Oxidants / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; D016877:Oxidants; D013481:Superoxides; D003189:p-Methoxy-N-methylphenethylamine; C040048:caffeic acid