Oligodendrocyte wars.
Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts. There are also ventral and dorsal sources in the forebrain, but here the more dorsal precursors prevail and the ventral-most lineage is eliminated during postnatal life. How do the different populations compete and what is the outcome of the competition? Do different embryonic origins signify different functional subgroups of oligodendrocyte?
Richardson
William D
WD
Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK. w.richardson@ucl.ac.uk
Kessaris
Nicoletta
N
Pringle
Nigel
N
D000818:Animals; D002454:Cell Differentiation; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D047108:Embryonic Development / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*