title: Antiviral Terpenoid Constituents of Ganoderma pfeifferi.
abstract: Four sterols and 10 triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new triterpenes 3,7,11-trioxo-5alpha-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5alpha-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.
authors.affiliation: Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany.
authors.forename: Timo H J
authors.initials: TH
authors.lastname: Niedermeyer
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lindequist
authors.forename: Renate
authors.initials: R
authors.lastname: Mentel
authors.forename: Dirk
authors.initials: D
authors.lastname: Gördes
authors.forename: Enrico
authors.initials: E
authors.lastname: Schmidt
authors.forename: Kerstin
authors.initials: K
authors.lastname: Thurow
authors.forename: Michael
authors.initials: M
authors.lastname: Lalk
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032902:Ganoderma / Q000737:chemistry*; D005858:Germany; D009980:Influenza A virus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018139:Simplexvirus / Q000187:drug effects*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D013261:Sterols; D013729:Terpenes