Perspicamides A and B, quinolinecarboxylic acid derivatives from the Australian ascidian Botrylloides perspicuum.
Two novel quinoline-2-carboxylic acid derivatives, perspicamides A (2) and B (3), were isolated from the Australian ascidian Botrylloides perspicuum. Extraction of the freeze-dried ascidian with methanol and purification of the extract by C18 MPLC followed by repeated C18 HPLC yielded the new compounds 2 and 3 as well as the known compounds botryllamides A-C (4-6). The structures of 2 and 3 were determined from analysis of 2D NMR spectra.
McKay
Matthew J
MJ
Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Queensland, Australia 4111.
Carroll
Anthony R
AR
Quinn
Ronald J
RJ
D000818:Animals; D001315:Australia; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification*; D014561:Urochordata / Q000737:chemistry*
D002264:Carboxylic Acids; D011804:Quinolines; C506988:perspicamide A; C506989:perspicamide B