title: Apolipoprotein D is associated with long-term outcome in patients with schizophrenia.
abstract: Accumulating evidence implicates deficiencies in apolipoprotein D (ApoD) function and arachidonic acid signaling in schizophrenic disorders. We addressed two hypotheses in relation to ApoD: first, polymorphisms in the ApoD gene confer susceptibility to or are markers of disease, and, second, genetic variation in the ApoD is associated with long-term clinical outcome to antipsychotic treatment. We genotyped two single-nucleotide polymorphisms in the ApoD gene in 343 chronic patients with schizophrenia spectrum disorders (ICD-10) and 346 control subjects of Danish origin. We did not find ApoD alleles, genotypes or haplotypes to be associated with disease. However, we did find that long-term clinical outcome was associated with the ApoD polymorphism rs7659 (P = 0.041) following adjustment for lifetime clinical global impression, age at first admission and gender.
authors.affiliation: Research Institute of Biological Psychiatry, Copenhagen University Hospital, H:S Sct. Hans Hospital, Roskilde, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Hansen
authors.forename: R P
authors.initials: RP
authors.lastname: Hemmingsen
authors.forename: A G
authors.initials: AG
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Olsen
authors.forename: S
authors.initials: S
authors.lastname: Timm
authors.forename: K
authors.initials: K
authors.lastname: Søeby
authors.forename: K D
authors.initials: KD
authors.lastname: Jakobsen
authors.forename: M
authors.initials: M
authors.lastname: Fenger
authors.forename: J
authors.initials: J
authors.lastname: Parnas
authors.forename: H B
authors.initials: HB
authors.lastname: Rasmussen
authors.forename: T
authors.initials: T
authors.lastname: Werge
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001053:Apolipoproteins / Q000235:genetics*; D053399:Apolipoproteins D; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001053:Apolipoproteins; D053399:Apolipoproteins D; D004247:DNA