Dopamine transporter imaging study in parkinsonism occurring in fragile X premutation carriers.
The authors studied four patients with parkinsonism carrying the fragile X premutation using SPECT with ([23)I]FP-CIT. They found evidence of preserved presynaptic nigrostriatal function, suggesting that parkinsonism in the X fragile premutation might be related to postsynaptic dopaminergic changes or different neurotransmitter alterations.
Ceravolo
R
R
Department of Neurosciences, University of Pisa, Italy. r.ceravolo@med.unipi.it
Antonini
A
A
Volterrani
D
D
Rossi
C
C
Goldwurm
S
S
Di Maria
E
E
Kiferle
L
L
Bonuccelli
U
U
Murri
L
L
D000368:Aged; D001284:Atrophy / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000235:genetics* / Q000378:metabolism*; D013378:Substantia Nigra / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D009435:Synaptic Transmission / Q000235:genetics; D013577:Syndrome; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
D015415:Biomarkers; D050483:Dopamine Plasma Membrane Transport Proteins; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine