title: Effect of oral colestimide on the elimination of high-dose methotrexate in patients with primary central nervous system lymphoma--case report.
abstract: Delayed methotrexate (MTX) elimination occurred in two patients with primary central nervous system lymphoma undergoing high-dose MTX treatment. Oral administration of the anion exchange resin colestimide, which binds MTX effectively in vitro, effectively accelerated MTX elimination. Colestimide probably interrupts the enterohepatic circulation, and is a potential oral antidote to MTX toxicity.
authors.affiliation: Department of Neurosurgery, Kumamoto University School of Medicine, Japan. kmakino@fc.kuh.kumamoto-u.ac.jp
authors.forename: Keishi
authors.initials: K
authors.lastname: Makino
authors.forename: Masato
authors.initials: M
authors.lastname: Kochi
authors.forename: Hideo
authors.initials: H
authors.lastname: Nakamura
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Kuroda
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Honda
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ushio
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kuratsu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D004811:Epichlorohydrin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D012117:Resins, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D007093:Imidazoles; D012117:Resins, Synthetic; C417427:colestimide; D004811:Epichlorohydrin; D008727:Methotrexate