title: Different modes of action of naphthyridones in gram-positive and gram-negative bacteria.
abstract: Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.
authors.affiliation: Department of Microbiology, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachuetts 02451, USA. Ed.Buurman@astrazeneca.com
authors.forename: Ed T
authors.initials: ET
authors.lastname: Buurman
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Johnson
authors.forename: Roxanne K
authors.initials: RK
authors.lastname: Kelly
authors.forename: Kathy
authors.initials: K
authors.lastname: MacCormack
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009287:Naphthyridines / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D009287:Naphthyridines