Synthesis of some oxazolinones and imidazolinones and their antimicrobial screening.
A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phe- nyl-4-acetylidene/benzylidene-imidazolin-5[4H]-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff's bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5[4H]-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imi- dazolin-5[4H]-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.
De
Biplab
B
Regional Institute of Pharmaceutical Science & Technology, Abhoynagar Agartala, Tripura-799005, India. biplab_32@yahoo.co.in
Gupta
Jayanta Kumar
JK
Saravanan
Venkatapuram Sampath
VS
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D048288:Imidazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D048288:Imidazolines; D010080:Oxazoles