title: Bilateral endogenous endophthalmitis in a patient with hemoglobin SC disease.
abstract: METHODS
  Bilateral endogenous endophthalmitis in the setting of pneumococcal bacteremia was diagnosed in a woman with hemoglobin SC disease who presented with decreased vision, increased redness, burning pain, and photophobia. All gram stains and cultures remained negative, and the exact source of her bacteremia was not clear. Nonetheless, early diagnosis and prompt treatment were vital to avoiding a visually devastating outcome.
  
  
  CONCLUSIONS
  Aggressive treatment with intravitreal and systemic antibiotics, with or without pars plana vitrectomy, was successful in restoring final visual acuity.
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Chang
authors.forename: Michael
authors.initials: M
authors.lastname: Rizen
authors.forename: Albert S
authors.initials: AS
authors.lastname: Jun
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002442:Ceftazidime / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D007839:Functional Laterality; D006450:Hemoglobin SC Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014640:Vancomycin / Q000627:therapeutic use; D014821:Vitrectomy
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D003907:Dexamethasone; D002442:Ceftazidime