An improved synthesis of resveratrol.
In this article we report an improved total synthesis of resveratrol, increasing the overall yield from 22 to 71%. The synthesis reported in our previous publication was made up of two fundamental steps: a Wittig reaction and a Heck coupling. Here we studied these steps separately to increase the individual yields. The yield of the Wittig reaction was increased up to 98%; however, we could not find better reaction conditions for the Heck coupling than those reported in the previous article.
Farina
Angela
A
Dipartimento di Chimica dell'Università "La Sapienza", Piazzale Aldo Moro 5, 00185 Roma, Italy.
Ferranti
Carolina
C
Marra
Carolina
C
D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis*
D013267:Stilbenes; D000077185:Resveratrol