Efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea.
OBJECTIVE
A double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea.


METHODS
All children from 6 months to 12 years with acute diarrhea were included. Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 received lactobacillus and 50 the placebo.


RESULTS
ORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in the lactobacillus group and none in the placebo group (OR 0.92, 95%CI 0.84-0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance.


CONCLUSIONS
There is no significant benefit of tyndalized Lactobacillus acidophilus in acute diarrhea.
Khanna
Vikrant
V
Department of Pediatrics, JN Medical College, Aligarh Muslim University, Aligarh, India.
Alam
Seema
S
Malik
Ashraf
A
Malik
Abida
A
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003967:Diarrhea / Q000628:therapy*; D004311:Double-Blind Method; D005440:Fluid Therapy; D006801:Humans; D007223:Infant; D007779:Lactobacillus acidophilus; D019936:Probiotics / Q000627:therapeutic use*