title: Exercise intolerance in patients with atrial fibrillation: clinical and echocardiographic determinants of exercise capacity.
abstract: Although exercise intolerance is a major symptom of patients with atrial fibrillation (AF), the factors limiting these patients' exercise capacity remains uncertain. This study evaluated the correlation of clinical and echocardiographic parameters with exercise capacity of patients with AF. In all, 73 patients (61 men and 12 women; mean age 61 years) with chronic AF were included in this study. Those patients with primary valvular diseases were excluded. Standard 2-dimensional and Doppler echocardiography was performed, and we averaged 10 consecutive measurements of each variable. Patients then underwent a symptom-limited treadmill exercise testing. We also measured patients' plasma levels of B-type natriuretic peptide before exercise testing. Of all clinical and echocardiographic parameters we assessed, age (r = -0.45, P = .006), ratio of early mitral inflow velocity to mitral annular velocity (r = -0.35, P = .032), and baseline heart rate were independent predictors of exercise capacity on multivariate regression analysis. In conclusion, patient's age, averaged ratio of early mitral inflow velocity to mitral annular velocity, and baseline heart rate provided useful information on exercise intolerance for patients with AF. Ratio of early mitral inflow velocity to mitral annular velocity, a noninvasive tool for estimating left ventricular filling pressure, may especially have important value for predicting functional capacity in this population as it has in individuals with in sinus rhythm.
authors.affiliation: Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. shl1106@hallym.ac.kr
authors.forename: Sang Hak
authors.initials: SH
authors.lastname: Lee
authors.forename: Jae-Hun
authors.initials: JH
authors.lastname: Jung
authors.forename: Seung-Hyuk
authors.initials: SH
authors.lastname: Choi
authors.forename: Namho
authors.initials: N
authors.lastname: Lee
authors.forename: Dong-Jin
authors.initials: DJ
authors.lastname: Oh
authors.forename: Kyu-Hyung
authors.initials: KH
authors.lastname: Ryu
authors.forename: Chong-Yun
authors.initials: CY
authors.lastname: Rhim
authors.forename: Kwang-Hwak
authors.initials: KH
authors.lastname: Lee
authors.forename: Yung
authors.initials: Y
authors.lastname: Lee
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D005080:Exercise Test / Q000379:methods*; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013318:Stroke Volume; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain