[Studies on peripheral blood & pathological index in inflammatory bowel disease of rats with clyster No. 1].
OBJECTIVE
To observe the effect of the clysters No. 1 of Traditional Chinese Medicine (TCM) in inflammatory bowel disease on rats and search the new way and evidence for IBD cures.


METHODS
The rats were divided into four groups: normal control group (I), model control group (II), Sulfasalazine( SASP) treating control group (III) and traditional Chinese medicine clysters No. 1 group (IV). There were 20 rats per group. Trinitrobenzenesulfonic Acid was used to induce the experimental models. The WBC, RBC, platelets of peripheral blood were monitored. The animals are put to death by dislocation in 4, 7, 14 and 21 d after giving the medicine respectively. The pathological changes of the intestines were observed in different times.


RESULTS
Compared with group II, the counting of platelets of group IV got rise in seventh day after administration, as of well as the group III. There were no statistical differences in WBC and RBC, compared with group II after the medicine administration for two weeks. There was no witness in effect of SASP for IBD on rats on organize pathology in this experiment. The enema No.1 lightened pathological injure and promoted the effect of restoration of IBD on rats obviously.


CONCLUSIONS
The TCM enema No. 1 has anti-IBD activities on inflammatory bowel disease in rats. The foundation is established that the IBD cure on clinic and the basis have been provided the action mechanism of Chinese medicine which is utilized to IBD further.
Liu
Ping
P
General Hospital of PA, Beijing 100853, China. liuping0707@yahoo.com.cn
Yang
Jie
J
Luo
Qing-liang
QL
Yu
Zu-yin
ZY
D000818:Animals; D003106:Colon / Q000473:pathology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004733:Enema / Q000379:methods; D006454:Hemoglobins / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000473:pathology; D007958:Leukocyte Count; D018655:Lymphocyte Count; D010946:Plants, Medicinal / Q000737:chemistry; D010976:Platelet Count; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012460:Sulfasalazine / Q000494:pharmacology
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D012460:Sulfasalazine