title: Tumor necrosis factor-alpha gene is not associated with obsessive-compulsive disorder.
abstract: Dysregulation of the immune system has been suggested to play a role in the complex etiology of obsessive-compulsive disorder. In this context, tumor necrosis factor-alpha is considered an interesting candidate for genetic studies as overproduction of tumor necrosis factor-alpha, which may be genetically modulated, can exert neurotoxic effects and influence neural cell growth and proliferation. Moreover, the tumor necrosis factor-alpha gene is located on chromosome 6p21.3, a region that has been found to be weakly associated with obsessive-compulsive disorder in linkage studies. One functional polymorphism, G-308A, has been found within the gene.
authors.affiliation: Institute of Medical Science, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Gwyneth
authors.initials: G
authors.lastname: Zai
authors.forename: Paul D
authors.initials: PD
authors.lastname: Arnold
authors.forename: Eliza
authors.initials: E
authors.lastname: Burroughs
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Richter
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D000483:Alleles; D005838:Genotype; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha