In vivo and in vitro studies of antibiotic release from and bacterial growth inhibition by antibiotic-impregnated polymethylmethacrylate hip spacers.
The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wound healing cannot be insufficient antibiotic release.
Kelm
Jens
J
Klinik für Orthopädie und Orthopädische Chirurgie, Homburg/Saar, Germany. jk66421@hotmail.com
Regitz
Thilo
T
Schmitt
Eduard
E
Jung
Werner
W
Anagnostakos
Konstantinos
K
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001419:Bacteria / Q000187:drug effects; D016503:Drug Delivery Systems; D004359:Drug Therapy, Combination; D006621:Hip Joint / Q000382:microbiology; D006801:Humans; D008422:Materials Testing; D019904:Polymethyl Methacrylate / Q000008:administration & dosage* / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000209:etiology; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D019904:Polymethyl Methacrylate