Changes in plasma testosterone levels and semen quality after 3 injections of a GnRH analogue in 3 dogs with spermatogenic dysfunction.
Three male Beagles with low plasma luteinizing hormone and testosterone levels and spermatogenic dysfunction (SD-dogs) were given 3 weekly subcutaneous injections of a gonadotropin-releasing hormone analogue (Buserelin; GnRH-AB). The plasma T level of all of the SD-dogs increased and peaked at 4-6 weeks after the first injection. The total number of sperm and the sperm motility of the three SD-dogs increased 5-7 weeks after the first injection. Therefore, the authors concluded that 3 weekly injections of GnRH-AB transiently improves semen quality in some cases of canine spermatogenic dysfunction.
Kawakami
Eiichi
E
Department of Reproduction, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Masaoka
Yosuke
Y
Hirano
Taichi
T
Hori
Tatsuya
T
Tsutsui
Toshihiko
T
D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy*; D004285:Dogs; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007248:Infertility, Male / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D012661:Semen / Q000166:cytology / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone