title: Novel bioactive parathyroid hormone and related peptides in teleost fish.
abstract: We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.
authors.affiliation: Centro de Ciências do Mar do Algarve, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. acanario@ualg.pt
authors.forename: Adelino V M
authors.initials: AV
authors.lastname: Canario
authors.forename: Josep
authors.initials: J
authors.lastname: Rotllant
authors.forename: Juan
authors.initials: J
authors.lastname: Fuentes
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Guerreiro
authors.forename: H
authors.initials: H
authors.lastname: Rita Teodósio
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Power
authors.forename: Melody S
authors.initials: MS
authors.lastname: Clark
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D008969:Molecular Sequence Data; D010281:Parathyroid Hormone / Q000096:biosynthesis* / Q000235:genetics; D010802:Phylogeny; D023741:Takifugu / Q000235:genetics / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone