Molecular communication through stochastic synchronization induced by extracellular fluctuations.
We model a synthetic gene regulatory network in a microbial cell, and investigate the effect of noises on cell-cell communication in a well-mixed multicellular system. A biologically plausible model is developed for cellular communication in an indirectly coupled multicellular system. Without extracellular noises, all cells, in spite of interaction among them, behave irregularly due to independent intracellular noises. On the other hand, extracellular noises that are common to all cells can induce collective dynamics and stochastically synchronize the multicellular system by actively enhancing the integrated interchange of signaling molecules.
Zhou
Tianshou
T
School of Mathematics and Computational Sciences, Zhongshan University, Guangzhou 510275, China. tszhou@msn.com
Chen
Luonan
L
Aihara
Kazuyuki
K
D048908:Aliivibrio fischeri / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D002450:Cell Communication; D015972:Gene Expression Regulation, Neoplastic; D008954:Models, Biological; D008957:Models, Genetic; D009876:Operon; D012097:Repressor Proteins / Q000235:genetics; D013269:Stochastic Processes; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D001426:Bacterial Proteins; C085427:LuxI protein, Bacteria; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C064778:LuxR autoinducer binding proteins