title: Vitamin E-coated filter decreases levels of free 4-hydroxyl-2-nonenal during haemodialysis sessions.
abstract: Uraemic subjects undergoing chronic haemodialysis show increased oxidative stress. The use of non-biocompatible filters and reduced antioxidative defences are important sources of reactive oxygen species (ROS) release. The highly oxidative environment accelerates the onset and progression of tissue damage and atherosclerotic cardiovascular disease. The aldehyde 4-hydroxyl-2-nonenal (HNE) is probably the best marker of oxidative stress. In this study, the concentration of plasma HNE was evaluated in eight uremic subjects during two sessions of haemodialysis: the first using a standard biocompatible filter and the second using a filter coated with vitamin E. Baseline plasma levels of HNE were elevated, and dropped during haemodialysis. At the end of the session, however, low levels were maintained only when the vitamin E-modified filter was used. By contrast, a marked increase in HNE was recorded at the end of the session in all subjects who underwent haemodialysis with the conventional filter. This study provides evidence that the vitamin E-coated filter plays a role in counteracting oxidative stress. The chronic use of vitamin E-modified filters in haemodialysed subjects might help to counterbalance oxidative attack and, consequently, contribute to preventing cardiovascular disease.
authors.affiliation: University of Genoa, Department of Internal Medicine and Medical Specialities, Genova, Italy. odetti@unige.it
authors.forename: Patrizio
authors.initials: P
authors.lastname: Odetti
authors.forename: Nicola
authors.initials: N
authors.lastname: Traverso
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Monacelli
authors.forename: Stefano
authors.initials: S
authors.lastname: Menini
authors.forename: Jana
authors.initials: J
authors.lastname: Vazzana
authors.forename: Bruno
authors.initials: B
authors.lastname: Tasso
authors.forename: Maria Adelaide
authors.initials: MA
authors.lastname: Pronzato
authors.forename: Cristina
authors.initials: C
authors.lastname: Robaudo
authors.forename: Giacomo
authors.initials: G
authors.lastname: Deferrari
mesh_terms: D000447:Aldehydes / Q000097:blood*; D020099:Coated Materials, Biocompatible; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism* / Q000473:pathology; D014810:Vitamin E
chemical_list: D000447:Aldehydes; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D014810:Vitamin E; C027576:4-hydroxy-2-nonenal