title: Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.
abstract: Attention deficit hyperactivity disorder (ADHD) is a common childhood psychiatric disorder which affects between 3% and 5% of school aged children. Despite much research, little is known regarding the aetiology of the disorder. Maternal cigarette smoking during pregnancy has been linked to a number of negative effects in offspring in infancy, childhood and even into adulthood and has been proposed as a possible risk factor for ADHD. The aim of this review was to discuss the evidence associating maternal smoking during pregnancy and ADHD as well as methodological issues concerning this association. A literature search using PubMed was employed using relevant keywords. The relevant reference sections of articles found were also searched. All English language studies published before June 2005 were assessed. A pooled odds ratio derived from case-control studies was also obtained. Despite methodological limitations, the majority of studies identify maternal smoking during pregnancy as a risk factor for ADHD behaviours. A pooled odds ratio indicates more than a two-fold increase in risk for a diagnosis of ADHD in those individuals whose mothers smoked during pregnancy (odds ratio 2.39, 95% confidence intervals 1.61, 3.52 P<0.001). Maternal smoking during pregnancy is a risk factor for ADHD behaviour and diagnoses, although the mechanisms through which such risks work is unknown.
authors.affiliation: Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK. langleyk@cardiff.ac.uk
authors.forename: K
authors.initials: K
authors.lastname: Langley
authors.forename: F
authors.initials: F
authors.lastname: Rice
authors.forename: M B M
authors.initials: MB
authors.lastname: van den Bree
authors.forename: A
authors.initials: A
authors.lastname: Thapar
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology*; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008425:Maternal Behavior / Q000523:psychology*; D009035:Mothers / Q000706:statistics & numerical data*; D009538:Nicotine / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D009538:Nicotine