Genomic regulation of Hox collinearity.
During vertebrate limb development, Hoxd genes are transcribed in two temporal phases; an early wave controls growth and polarity up to the forearm and a late wave patterns the digits. In this issue of Developmental Cell, Tarchini and Duboule (2006) report that two opposite regulatory modules direct early collinear expression of Hoxd genes.
Freitas
Renata
R
Department of Zoology, University of Florida, P.O. Box 118525, Gainesville, Florida 32611, USA.
Cohn
Martin J
MJ
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D005121:Extremities / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox / Q000235:genetics / Q000502:physiology*; D023281:Genomics; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice
D018398:Homeodomain Proteins