Clinicopathologic correlation of stage 2 macular hole.
OBJECTIVE
To provide histopathologic correlation of the appearance of a stage 2 macular hole.


METHODS
A 79-year-old woman presented with a recent onset of mildly decreased vision in the right eye. With slit-lamp biomicroscopic examination and fundus photography, she was diagnosed as having a stage 2 macular hole. Her vision remained stable thereafter without intervention for 15 months. She died 6 months after her final follow-up examination. Postmortem histopathologic examination of the right eye was carried out by light microscopy of conventional and immunoperoxidase-stained sections.


RESULTS
The clinical appearance of a stage 2 macular hole in this patient corresponded with findings of intraretinal splitting, which extended beyond an area of surface retinal defect.


CONCLUSIONS
Surface retinal defects associated with intraretinal splitting are a pathway in the development of a macular hole.
Hwang
Thomas S
TS
Casey Eye Institute, Oregon Health & Science University, Portland, 97239, USA.
Wilson
David J
DJ
Klein
Michael L
ML
D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D012167:Retinal Perforations / Q000145:classification / Q000473:pathology*