title: Gastrointestinal stromal tumor (GIST) with glandular component. A report of an unusual tumor resembling adenosarcoma.
abstract: A case of gastrointestinal stromal tumor (GIST) with an unusual glandular component is reported. The tumor was found in the gastric fundus of a 93-year-old woman. Histologically, the lesion showed a biphasic adenosarcoma-like structure. Typical low-grade spindle cell patterns of GIST were intermingled with numerous and partly cystic glands. The glandular epithelium had pyloric/foveolar-like appearance, with foci of intestinal metaplasia and low-grade dysplasia. The stromal component was immunoreactive for CD117 (c-kit) and CD34, and negative for myoid and neuroid markers. The ultrastructural examination found nondescript and undifferentiated spindle cells. The gastric mucosa and submucosa near the tumor contained a small area with features of gastritis cystica profunda, with glands similar to those present inside the tumor. Therefore, a collision of GIST and gastritis cystica profunda is suggested in the histogenesis of the lesion.
authors.affiliation: Sikl's Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic. zamecnik@medima.cz
authors.forename: M
authors.initials: M
authors.lastname: Zámecník
authors.forename: B
authors.initials: B
authors.lastname: Sosna
authors.forename: A
authors.initials: A
authors.lastname: Chlumská
mesh_terms: D018195:Adenosarcoma / Q000473:pathology*; D000369:Aged, 80 and over; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D006801:Humans; D013274:Stomach Neoplasms / Q000473:pathology*