title: Daily profile of plasma %CoQ10 level, a biomarker of oxidative stress, in patients with diabetes manifesting postprandial hyperglycaemia.
abstract: The purpose of this study was to investigate the effect of regular meals on the daily profile of blood oxidative stress markers in type 2 diabetic patients with postprandial hyperglycaemia. %CoQ10, calculated as the ratio of ubiquinone-10 (oxidised form of coenzyme Q10) to ubiquinol-10 (reduced form), was used as a sensitive marker of oxidative stress. Blood samples were collected from patients before and 2 h after breakfast, lunch and supper, and at 10 p.m. Patients were selected for the study if their blood glucose levels were <7 mmol/l before breakfast and > or =11.1 mmol/l on at least one occasion after breakfast. %CoQ10 levels after breakfast and throughout the day were significantly higher than those before breakfast (p=0.006-0.04). In contrast to the wave-like changes in plasma glucose levels, %CoQ10 levels increased after breakfast and remained at high levels throughout the day. These results indicated that diabetic patients with postprandial hyperglycaemia were exposed to meal-induced periods of oxidative stress during the day. Postprandial hyperglycaemia therefore has the potential to increase the risk of atherosclerotic cardiovascular disease through induction of oxidative stress.
authors.affiliation: Department of Endocrinology and Metabolism, Kyoto Prefectural University, Medicine Graduate School of Medical Science, Hirokoji, Kawaramachi-dori, Kamikyo-ku, Japan. goji@koto.kpu-m.ac.jp
authors.forename: G
authors.initials: G
authors.lastname: Hasegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: J G
authors.initials: JG
authors.lastname: Zhi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanino
authors.forename: M
authors.initials: M
authors.lastname: Yamasaki
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: M
authors.initials: M
authors.lastname: Fukui
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003067:Coenzymes; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D018384:Oxidative Stress; D018579:Patient Selection; D019518:Postprandial Period; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D003067:Coenzymes; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10; D001205:Ascorbic Acid