[Clinical study of relationship between serum procalcitonin and severity of multiple organ dysfunction syndrome].
OBJECTIVE
To study the correlation between serum procalcitonin (PCT) level and severity of multiple organ dysfunction syndrome (MODS).


METHODS
Sixty-one patients with MODS were enrolled in this study. They were divided into infection group and non-infection group. Serum PCT were measured using an immunoluminometric assay. Acute physiology and chronic health evaluation II (APACHE II) scores and Marshall scores of the two groups were recorded and the relationship between PCT levels and APACHE II scores as well as Marshall scores was analysed.


RESULTS
Serum PCT levels in patients with MODS were higher. Serum PCT [13.01(2.73, 64.79) microg/L], APACHE II [(17.50+/-5.35) scores] and Marshall score [(6.38+/-2.46) scores] of infection group were significantly higher than non-infection group [1.50 (0, 2.98) microg/L, (14.67+/-3.01) scores, and (4.62+/-2.01) scores, respectively, P<0.05 or P<0.001]. Serum PCT of infection group and non-infection group did not show correlation with APACHE II (r=0.175, P=0.281; r=0.071, P=0.759). Serum PCT of all patients with MODS showed positive correlation with Marshall score (r=0.514, P<0.001), and correlation index of infection group was higher (r=0.535, P<0.001). Serum PCT of non-infection group did not show correlation with Marshall score (r=0.003, P=0.991).


CONCLUSIONS
Serum PCT has clinical values in judgment of the severity of infected patients complicated by MODS.
Ge
Qing-gang
QG
Intensive Care Unit, Third Hospital, Peking University, Beijing 100083, China.
Yin
Cheng-hong
CH
Wen
Yan
Y
Lü
Jing-qiao
JQ
Wang
Yi-bing
YB
D018806:APACHE; D000328:Adult; D000368:Aged; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D055815:Young Adult
C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide