Natural and synthetic G-quadruplex interactive berberine derivatives.
The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding.
Franceschin
Marco
M
Dipartimento di Chimica, Università di Roma La Sapienza, Piazzale A. Moro 5, 00185 Rome, Italy.
Rossetti
Luigi
L
D'Ambrosio
Anna
A
Schirripa
Stefano
S
Bianco
Armandodoriano
A
Ortaggi
Giancarlo
G
Savino
Maria
M
Schultes
Christoph
C
Neidle
Stephen
S
D000970:Antineoplastic Agents / Q000378:metabolism*; D001600:Berberine Alkaloids / Q000138:chemical synthesis* / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D006801:Humans; D007364:Intercalating Agents / Q000378:metabolism; D008024:Ligands; D009691:Nucleic Acid Denaturation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry* / Q000378:metabolism; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism; D019098:Telomerase / Q000037:antagonists & inhibitors*; D016615:Telomere / Q000187:drug effects*
D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D007364:Intercalating Agents; D008024:Ligands; D009692:Nucleic Acid Heteroduplexes; D010880:Piperidines; C032727:piperidine; C000666:coralyne; D004247:DNA; D019098:Telomerase