[Effects of early intestinal application of sijunzi decoction on immune function in post-operational patients of gastrointestinal tumor].
OBJECTIVE
To assess the effects of early intestinal application of sijunzi decoction (SJZD) on the immune function in post-operational patients of gastrointestinal tumor.


METHODS
Ninety-two patients with malignant gastrointestinal tumor were randomly divided into two groups. Patients in both groups were given the isocaloric and isonitrogenous enteral nutritional support starting from the first day after operation for 1 week, but to the tested group, SJZD was given additionally. The concentration of serum cytokines such as interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), the peripheral blood cell counts of total lymphocyte, T-lymphocyte, B lymphocyte, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) as well as the levels of IgA, IgG, IGM and C-reactive protein (CRP) were measured on the day before operation, the first morning after operation and at the end of study.


RESULTS
At the end of the study, the concentration of IgA, IgG, 1gM, number of total lymphocyte, CD3, CD4 and CD4 lCD8, and serum IL-2 were obviously higher (P < 0.05), and levels of IL-6, TNF-alpha and CRP were obviously lower in the tested group than those in the control group (P < 0.05).


CONCLUSIONS
Early application of SJZD on the base of enteral nutritional therapy can lessen the degree of post-operational stress and inflammatory response, and enhance the immune function of patients.
Liang
Chao
C
Department of General Surgery, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437. LCHAO2003@msn.com
Zhang
Sheng-hua
SH
Cai
Zhao-di
ZD
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000276:immunology* / Q000601:surgery; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011184:Postoperative Period
D004365:Drugs, Chinese Herbal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007375:Interleukin-1; D007376:Interleukin-2; C403259:si-jun-zi-tang