title: Evidence for an exaggerated postprandial lipemia in chronic paraplegia.
abstract: OBJECTIVE
  Excessive delay in triglyceride (TG) metabolism after ingestion of dietary fat represents a significant cardiovascular disease (CVD) risk. The objective of this study was to compare the postprandial lipemic responses of individuals with paraplegia with those of healthy nondisabled individuals.
  
  
  METHODS
  The ability of 3 recreationally active individuals with paraplegia having normal fasting TG (mean = 103 mg/dL) to metabolize TG after ingestion of a high-fat test meal was compared with a previously published cohort of 21 recreationally active individuals without paraplegia (TG mean = 86 mg/dL) who underwent identical testing. The subjects with paraplegia had venous blood taken under fasting conditions, and then ingested a milkshake containing premium ice cream blended with heavy whipping cream (approximately 92% of calories from fat). Additional blood samples were obtained at 2, 4, and 6 hours after ingestion. The area under the curve (AUC) for TG clearance for both subject groups was measured with an area planimeter.
  
  
  RESULTS
  TG uptake for both groups was almost identical for the first 2 hours after ingestion. At 4 and 6 hours after ingestion, the TG levels were 50 and 35 mg/dL higher, respectively, in subjects with paraplegia than in nondisabled subjects. When corrected for small baseline differences in TG concentrations (16 mg/dL), the AUC was 46.5% greater for the group with paraplegia than in the nondisabled group. A near mirror association across time was observed between postprandial serum high-density lipoprotein cholesterol (HDL-C) and TG levels in subjects with paraplegia.
  
  
  CONCLUSIONS
  This case series finds an exaggerated postprandial lipemia (PPL) in persons with paraplegia with normal fasting TGs. This finding is the first evidence, in a small population, of an unreported potential CVD risk in persons with paraplegia.
authors.affiliation: Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA. msnash@miami.edu
authors.forename: Mark S
authors.initials: MS
authors.lastname: Nash
authors.forename: Joris
authors.initials: J
authors.lastname: DeGroot
authors.forename: Alberto
authors.initials: A
authors.lastname: Martinez-Arizala
authors.forename: Armando J
authors.initials: AJ
authors.lastname: Mendez
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D002908:Chronic Disease; D015331:Cohort Studies; D004435:Eating; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000097:blood*; D012307:Risk Factors; D013119:Spinal Cord Injuries / Q000097:blood*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides