Chronic granulomatous disease.
A 2(1/2)-year-old child presented with multiple discrete granulomatous lesions on the face and flexural regions since the age of 2 months along with lymphadenopathy. The patient also had recurrent bouts of pyodermas and respiratory tract infections. Biopsy of the lesion showed necrosis of tissue with suppuration and histiocytes but no evidence of tuberculosis, fungal infections or atypical mycobacteria. Lymph node biopsy also showed necrosis with suppuration but no infective organism. Nitroblue tetrazolium test was negative indicating that the neutrophils failed to oxidize the dye. We are reporting here a rare case of chronic granulomatous disease.
Nair
Pradeep S
PS
Department of Dermatology and Venereology, Medical College Hospital, Trivandrum 695011, Kerala, India. bijili@asianetindia.com
Moorthy
Prasanna K
PK
Suprakasan
S
S
Jayapalan
Sabeena
S
Preethi
K
K
D001707:Biopsy, Needle; D002675:Child, Preschool; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000151:congenital* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009580:Nitroblue Tetrazolium; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index
D009580:Nitroblue Tetrazolium