Nosocomial invasive infection caused by Cunninghamella bertholletiae: case report.
Human infection by Cunninghamella bertholletiae occurs almost exclusively in immunocompromised patients. Infections due to this microorganism have been most frequently diagnosed in patients with hematological malignancies, with neutropenia and in diabetes mellitus patients. This work reports a case of fungal infection by Cunninghamella bertholletiae isolated from blood in a man with a complex clinical picture, involving diabetes and pharmacological immunosupression. Blood culture at room temperature and at 37 degrees C on Sabouraud agar grew a single mold with characteristic properties of Cunninghamella. In the microscopic morphology, were found wide, non-septate, branching hyphae with erect sporangiophores terminated in swollen vesicles and sporangioles borne off the vesicles. C. bertholetiae was identified after subculture on Sabouraud dextrose agar at 45 degrees C. The patient died 15 days after the beginning of amphotericin B therapy.
Passos
Xisto Sena
XS
Universidade Paulista, Goiania, Goias, Brazil.
Sales
Werther Souza
WS
Maciel
Patrícia Jackeline
PJ
Costa
Carolina Rodrigues
CR
Ferreira
Denise Milioli
DM
do Silva
Maria Rosário Rodrigues
MR
D003428:Cross Infection / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D020093:Cunninghamella / Q000254:growth & development*; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy / Q000276:immunology*