title: Synthesis and cytotoxicity of new heterocyclic terpenylnaphthoquinones.
abstract: Several 2-arylamino-, 2-aryloxy- and 2-arylsulfanyl-6(7)-alkyl-1,4-naphthoquinones (NQ) have been prepared and further transformed into the corresponding heterocyclic-fused naphthoquinones by palladium (II)-catalyzed oxidative cyclization. The compounds synthesized have been evaluated against neoplastic cell lines. The extension of the polycyclic system clearly decreased the cytotoxic potency of the 2-substituted terpenylnaphthoquinones.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007-Salamanca, Spain. jmmcs@usal.es
authors.forename: José M
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: Castro
authors.forename: Marina
authors.initials: M
authors.lastname: Gordaliza
authors.forename: Maria Luz
authors.initials: ML
authors.lastname: Martín
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Gamito
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
authors.forename: Arturo San
authors.initials: AS
authors.lastname: Feliciano
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000970:Antineoplastic Agents; D009285:Naphthoquinones