title: A call for the creation of personalized medicine databases.
abstract: The success of the Human Genome Project raised expectations that the knowledge gained would lead to improved insight into human health and disease, identification of new drug targets and, eventually, a breakthrough in healthcare management. However, the realization of these expectations has been hampered by the lack of essential data on genotype--drug-response phenotype associations. We therefore propose a follow-up to the Human Genome Project: forming global consortia devoted to archiving and analysing group and individual patient data on associations between genotypes and drug-response phenotypes. Here, we discuss the rationale for such personalized medicine databases, and the key practical and ethical issues that need to be addressed in their establishment.
authors.affiliation: Department of Human Genetics & Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel. gurwitz@post.tau.ac.il
authors.forename: David
authors.initials: D
authors.lastname: Gurwitz
authors.forename: Jeantine E
authors.initials: JE
authors.lastname: Lunshof
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
mesh_terms: D001675:Bioethics; D016208:Databases, Factual; D004358:Drug Therapy / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D010597:Pharmacogenetics