Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia?
Abnormal levels of interleukin (IL)-6 were described in patients with ALS, related to an inflammatory process. The authors compared IL-6 and tumor necrosis factor alpha (TNF-alpha) levels in CSF and sera from 10 hypoxemics and 10 normoxemics patients with ALS to those of 10 hypoxemics and 10 normoxemics neurologic controls. The same pattern exists in patients with ALS and controls: the highest levels are found in hypoxic conditions and undetectable levels are found in normoxemic conditions. Elevated IL-6 levels in ALS could correspond to a normal response to hypoxemia.
Moreau
C
C
Department of Neurology, INSERM, Pasteur Institute of Lille, University Hospital, Lille, France.
Devos
D
D
Brunaud-Danel
V
V
Defebvre
L
L
Perez
T
T
Destée
A
A
Tonnel
A B
AB
Lassalle
P
P
Just
N
N
D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000276:immunology* / Q000503:physiopathology; D015850:Interleukin-6 / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D008297:Male; D017628:Microglia / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D009187:Myelitis / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000276:immunology; D011237:Predictive Value of Tests; D012131:Respiratory Insufficiency / Q000276:immunology / Q000503:physiopathology; D012132:Respiratory Muscles / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology
D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha