title: Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics.
abstract: The present commentary aims to review the modern and innovative strategies in particle engineering by the supercritical fluid technologies and it is principally concerned with the aspects of solid-state chemistry. Supercritical fluids based processes for particle production have been proved suitable for controlling solid-state, morphology and particle size of pharmaceuticals, in some cases on an industrial scale. Supercritical fluids should be considered in a prominent position in the development processes of drug products for the 21st century. In this respect, this innovative technology will help in meeting the more and more stringent requirements of regulatory authorities in terms of solid-state characterisation and purity, and environmental acceptability.
authors.affiliation: Department of Pharmacy, University of Parma, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Pasquali
authors.forename: Ruggero
authors.initials: R
authors.lastname: Bettini
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Giordano
mesh_terms: D000420:Albuterol / Q000031:analogs & derivatives / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001993:Bronchodilator Agents / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry*; D015790:Cefonicid / Q000737:chemistry; D011232:Chemical Precipitation; D003460:Crystallization; D010316:Particle Size; D044367:Phase Transition; D011208:Powders; D011312:Pressure; D011786:Quality Control; D000068299:Salmeterol Xinafoate; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D001993:Bronchodilator Agents; D011208:Powders; D012997:Solvents; D002245:Carbon Dioxide; D015790:Cefonicid; D000068299:Salmeterol Xinafoate; D000420:Albuterol