Auto-redox reaction: tin(II) chloride-mediated one-step reductive cyclization leading to the synthesis of novel biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity.
[reaction: see text] A tin(II) chloride-mediated short, efficient, and practical regioselective synthesis of biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity is reported. A one-step reductive transformation of 2-(2-nitrophenyl)-3H-quinazolin-4-one in various alcohols furnished the desired tetracyclic product in good yields with high purity.
Roy
Abhijeet Deb
AD
Division of SAIF, Central Drug Research Institute, Lucknow 226 001, India.
Subramanian
Arunachalam
A
Roy
Raja
R
D002712:Chlorides / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D014001:Tin / Q000737:chemistry*
D002712:Chlorides; D011799:Quinazolines; D014001:Tin