title: PET/CT: dose-escalated image fusion?
abstract: Clinical studies demonstrate a gain in diagnostic accuracy by employing combined PET/CT instead of separate CT and PET imaging. However, whole-body PET/CT examinations result in a comparatively high radiation burden to patients and thus require a proper justification and optimization to avoid repeated exposure or over-exposure of patients. This review article summarizes relevant data concerning radiation exposure of patients resulting from the different components of a combined PET/CT examination and presents different imaging strategies that can help to balance the diagnostic needs and the radiation protection requirements. In addition various dose reduction measures are discussed, some of which can be adopted from CT practice, while others mandate modifications to the existing hard- and software of PET/CT systems.
authors.affiliation: Federal Office for Radiation Protection, Division of Medical Radiation Hygiene and Dosimetry, Neuherberg, Germany. gbrix@bfs.de
authors.forename: G
authors.initials: G
authors.lastname: Brix
authors.forename: T
authors.initials: T
authors.lastname: Beyer
mesh_terms: D004781:Environmental Exposure; D006801:Humans; D007091:Image Processing, Computer-Assisted; D049268:Positron-Emission Tomography; D011829:Radiation Dosage; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed