Detection of von Willebrand factor and tissue factor in platelets-fibrin rich coronary thrombi in acute myocardial infarction.
The rapid closure of coronary arteries due to occlusive thrombi is the major cause of acute myocardial infarction. However, the mechanisms of coronary thrombus formation have not been elucidated. We immunohistochemically assessed the localizations and their changes over time of glycoprotein IIb/IIIa, fibrin, von Willebrand factor (vWF), and tissue factor (TF), after the onset of chest pain (<4, 4 to 6, or 6 to 12 hours), in fresh coronary thrombi causing acute myocardial infarction. The occlusive thrombi were consistently composed of platelets, fibrin, vWF, and TF from the early phase of onset, and glycoprotein IIb/IIIa and fibrin were closely associated with vWF and TF, respectively. vWF and/or TF may contribute to occlusive thrombus formation and be novel therapeutic candidates for treating patients with coronary thrombosis.
Yamashita
Atsushi
A
Department of Pathology, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Sumi
Takahiro
T
Goto
Shinya
S
Hoshiba
Yasunari
Y
Nishihira
Kensaku
K
Kawamoto
Riichirou
R
Hatakeyama
Kinta
K
Date
Haruhiko
H
Imamura
Takuroh
T
Ogawa
Hisao
H
Asada
Yujiro
Y
D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D003328:Coronary Thrombosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014841:von Willebrand Factor; D005337:Fibrin; D013925:Thromboplastin