title: [Liver regeneration after major hepatectomy. Evaluation of dogs hepatectomy].
abstract: OBJECTIVE
  The aim of our study is to evaluate anatomic regeneration and metabolic derangement of the liver after major resection in dogs.
  
  
  METHODS
  This is an experimental study on 9 dogs; we divided the dogs in two groups: the first group (5 dogs) underwent at one go major hepatectomy (90% of the liver). The second group (4 dogs) underwent successively a resection of 75% of the liver and a second resection of 90% of the restored liver six months later. All dogs underwent a metabolic and morphologic studies of the liver and of their kidney function.
  
  
  RESULTS
  In the first group; all dogs which underwent 90% hepatic resection died 48 hours after the surgical resection of hepatic insufficiency. The ultra microscopic study showed the role of portal hypertension in hepatic degeneration on the first group. In the second group, the dogs survived the first resection, and our study shows a regeneration of the liver after resection and sub normal hepatic function.
  
  
  CONCLUSIONS
  The liver is able to regenerate after minimally resection but major resection must be done by successively resection to avoid hepatic dysfunction, but the time between resection must be evaluate later.
authors.affiliation: Service de chirurgie viscérale, Hôpital militaire de Tunis.
authors.forename: Ben Aleya
authors.initials: BA
authors.lastname: Mohamed
authors.forename: Chahbani
authors.initials: C
authors.lastname: Sami
authors.forename: B Khlifa
authors.initials: BK
authors.lastname: Mohamed
authors.forename: Hlali
authors.initials: H
authors.lastname: Abdeljabar
authors.forename: Ben Ali
authors.initials: BA
authors.lastname: Ali
authors.forename: Moalla
authors.initials: M
authors.lastname: Noomen
authors.forename: N Gordah
authors.initials: NG
authors.lastname: Ahmed
authors.forename: H Manai
authors.initials: HM
authors.lastname: Mohamed
authors.forename: Jabbès
authors.initials: J
authors.lastname: Hatem
authors.forename: Essoussi
authors.initials: E
authors.lastname: Mohamed
authors.forename: Jaafoura
authors.initials: J
authors.lastname: Habib
authors.forename: Ben Amor
authors.initials: BA
authors.lastname: Awatef
authors.forename: Haddad
authors.initials: H
authors.lastname: Slim
authors.forename: Ammara
authors.initials: A
authors.lastname: Ali
mesh_terms: D000818:Animals; D004285:Dogs; D006498:Hepatectomy; D006975:Hypertension, Portal; D008099:Liver / Q000502:physiology; D008115:Liver Regeneration / Q000502:physiology*; D013534:Survival