title: Influence of personality disorder on the treatment of panic disorder--comparison study.
abstract: Most clinicians tend to believe that the occurrence of the anxiety disorder in comorbidity with a personality disorder often leads to longer treatment, worsens the prognosis, and thus increasing treatment costs. The study is designed to compare the short-term effectiveness of combination of cognitive behavioral therapy and pharmacotherapy in patient suffering with panic disorder with and without personality disorder.
  
  
  METHODS
  We compare the efficacy of 6th week therapeutic program and 6th week follow up in patients suffering with panic disorder and/or agoraphobia and comorbid personality disorder (29 patients) and panic disorder and/or agoraphobia without comorbid personality disorder (31 patients). Diagnosis was done according to the ICD-10 research diagnostic criteria confirmed with MINI and support with psychological methods: IPDE, MCMI-III and TCI. Patients were treated with CBT and psychopharmacs. They were regularly assessed in week 0, 2, 4, 6 and 12 by an independent reviewer on the CGI (Clinical Global Improvement) for severity and change, PDSS (Panic Disorder Severity Scale), HAMA (Hamilton Anxiety Rating Scale), SDS (Sheehan Disability Scale), HDRS (Hamilton Depression Rating Scale), and in self-assessments BAI (Beck Anxiety Inventory) and BDI (Beck Depression Inventory).
  
  
  RESULTS
  A combination of CBT and pharmacotherapy proved to be the effective treatment of patients suffering with panic disorder and/or agoraphobia with or without comorbid personality disorder. The 12th week treatment efficacy in the patients with panic disorder without personality disorder had been showed significantly better compared with the group with panic disorder comorbid with personality disorder in CGI and specific inventory for panic disorder--PDSS. Also the scores in depression inventories HDRS and BDI showed significantly higher decrease during the treatment comparing with group without personality disorder. But the treatment effect between groups did not differ in objective anxiety scale HAMA, and subjective anxiety scale BAI.
authors.affiliation: Prague Psychiatric Center, Ustavní 91, 181 03 Prague, Czech Republic. prasko@pcp.lf3.cuni.cz
authors.forename: Ján
authors.initials: J
authors.lastname: Prasko
authors.forename: Petra
authors.initials: P
authors.lastname: Houbová
authors.forename: Tomás
authors.initials: T
authors.lastname: Novák
authors.forename: Richard
authors.initials: R
authors.lastname: Záleský
authors.forename: Katerina
authors.initials: K
authors.lastname: Espa-Cervená
authors.forename: Beata
authors.initials: B
authors.lastname: Pasková
authors.forename: Jana
authors.initials: J
authors.lastname: Vyskocilová
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000150:complications* / Q000628:therapy; D000525:Alprazolam / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000150:complications* / Q000628:therapy*; D017374:Paroxetine / Q000627:therapeutic use; D010554:Personality Disorders / Q000150:complications* / Q000628:therapy; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D000525:Alprazolam; D014151:Anti-Anxiety Agents; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors