title: Effect of statin on restenosis after radius stent implantation in patients with acute coronary syndrome.
abstract: Despite reports that statin treatment reduces the rate of coronary restenosis with a balloon expandable stent, there is no evidence that statins affect the incidence of restenosis with a self-expanding Radius stent. Ninety-five patients with acute coronary syndrome who had been implanted with a Radius stent were classified into two groups: those with hyperlipidemia and initial statin treatment (statin group, n = 38) and those without statin treatment (comparative group, n = 57). At six months after stent implantation, the rate of coronary restenosis was significantly lower in the statin group (10.5%) than control group (28.1%) (p = 0.033), while there were no differences in morphology, maximal inflation pressure or stent size between the two groups. Interestingly, there was no difference in the serum lipid profile between the two groups at the 6-month follow-up, although the statin group had a significantly lower rate of restenosis. In conclusion, initial statin therapy reduced the rate of coronary restenosis even when a Radius stent was implanted.
authors.affiliation: Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Miura
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimomura
authors.forename: Akira
authors.initials: A
authors.lastname: Kawamura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tsujita
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shirai
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Arai
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D000208:Acute Disease; D000368:Aged; D003131:Combined Modality Therapy; D003251:Constriction, Pathologic / Q000517:prevention & control*; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015607:Stents
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors