Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.
Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.
Liu
Rui
R
Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
Cui
Cheng-Bin
CB
Duan
Lin
L
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005591:Chemical Fractionation / Q000379:methods; D002725:Chloroform / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016930:Saccharopolyspora / Q000737:chemistry*
D000970:Antineoplastic Agents; D010860:Pigments, Biological; C098402:metacycloprodigiosin; C047347:undecylprodigiosin; D002725:Chloroform; D011353:Prodigiosin