CDKN2A common variant and multi-organ cancer risk--a population-based study.
The population frequencies of the CDKN2A common variants remain undetermined. In Poland, there is a common variant of the CDKN2A: an alanine to threonine substitution (A148T), which has been detected in other populations. We have recently showed that it is significantly overrepresented among Polish melanoma patients when compared to general population. Herein, we ascertained the prevalence of the A148T variant in 3,583 unselected cancer cases and 3,000 random control subjects from the same Polish population. We evaluated eleven different malignancies, representing the majority of all common cancer sites. Positive association with A148T variant was observed for lung cancer (OR, 2.0; p = 0.0052). A similar trend, although nonsignificant after the Bonferroni correction, was observed for colorectal cancer (OR, 1.5; p = 0.5499). These results suggest that A148T variant may be associated with a multi-organ cancer risk in the Polish population.
Debniak
Tadeusz
T
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. debniak@wp.pl
Scott
Rodney J
RJ
Huzarski
Tomasz
T
Byrski
Tomasz
T
Rozmiarek
Andrzej
A
Debniak
Boguslaw
B
Górski
Bohdan
B
Cybulski
Cezary
C
Medrek
Krzysztof
K
Mierzejewski
Marek
M
Masojc
Bartłomiej
B
Matyjasik
Joanna
J
Złowocka
Elzbieta
E
Teodorczyk
Urszula
U
Lener
Marcin
M
Klujszo-Grabowska
Ewa
E
Nej-Wołosiak
Katarzyna
K
Jaworowska
Ewa
E
Oszutowska
Dorota
D
Szymańska
Anna
A
Szymańska
Jolanta
J
Castaneda
Jennifer
J
van de Wetering
Thierry
T
Suchy
Janina
J
Kurzawski
Grzegorz
G
Oszurek
Oleg
O
Narod
Steven
S
Lubinski
Jan
J
D000328:Adult; D000368:Aged; D000409:Alanine; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics*; D005260:Female; D019942:Genes, p16; D014644:Genetic Variation; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013912:Threonine
D019941:Cyclin-Dependent Kinase Inhibitor p16; D013912:Threonine; D000409:Alanine