Inflamed fat: what starts the fire?
Obesity is associated with increased macrophage infiltration of adipose tissue, and these macrophages may be an important component of the chronic inflammatory response playing a crucial role in the development of insulin resistance. This prompts the question as to how macrophages infiltrate obese adipose tissue. In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications.
Neels
Jaap G
JG
Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California 92093-0673, USA.
Olefsky
Jerrold M
JM
D000273:Adipose Tissue / Q000503:physiopathology*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009765:Obesity / Q000503:physiopathology* / Q000517:prevention & control; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics / Q000502:physiology*
C515334:CCR2 protein, human; C515335:Ccr2 protein, mouse; D054390:Receptors, CCR2; D019707:Receptors, Chemokine