No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population.
OBJECTIVE
A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.


METHODS
We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).


RESULTS
We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.


CONCLUSIONS
The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.
Lindberg
C
C
Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen & Rigshospitalet University Hospital, Copenhagen, Denmark.
Koefoed
P
P
Hansen
E S
ES
Bolwig
T G
TG
Rehfeld
J F
JF
Mellerup
E
E
Jørgensen
O S
OS
Kessing
L V
LV
Werge
T
T
Haugbøl
S
S
Wang
A G
AG
Woldbye
D P D
DP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D017931:DNA Primers / Q000235:genetics; D003718:Denmark / Q000453:epidemiology; D003866:Depressive Disorder / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D016584:Panic Disorder / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D012559:Schizophrenia / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*
D017931:DNA Primers; D009478:Neuropeptide Y