title: Body surface potential mapping investigating the ventricular activation patterns in the cardiac resynchronization of patients with left bundle-branch block and heart failure.
abstract: Body surface potential mapping assessed mean cardiac electrical activation times displayed by isochronal maps in the right ventricle (RV; right ventricle mean activation time [mRV]), anterior septal area (anterior septal area mean activation time [mAS]), and left ventricle (left ventricle mean activation time [mLV]) of 28 patients (mean, 61.07 years; congestive heart failure class III-IV; ejection fraction, < or =40%; left bundle-branch block [LBBB] QRS, 180.17 milliseconds), before and after biventricular pacemaker implantation, comparing them, using reference values from a control group of healthy individuals with normal hearts (GNL), in (1) baseline native LBBB, where mRV and mAS values were similar (40.99 vs 43.62 milliseconds), with mLV delayed (80.99 milliseconds, P < .01) and dyssynchronous with RV/anterior septal area; (2) single-site RV pacing, where mRV was greater than in GNL (86.82 milliseconds, P < .001), with greater mAS/mLV difference (63.41 vs 102.7 milliseconds; P < .001); and (3) biventricular pacing (BIV-PM), where mLV and mRV were similar (71.99 vs 71.58 milliseconds), mRV was greater than in GNL and native LBBB (71.58 vs 35.1 and 40.99 milliseconds; P < .001), and mAS approached values in GNL and native LBBB (51.28 vs 50.14 and 43.62 milliseconds). Body surface potential mapping showed that similar RV/left ventricle activation times during biventricular pacing, nearing mAS, indicate synchronized ventricular activation pattern in patients with congestive heart failure/LBBB.
authors.affiliation: Heart Institute (InCor) of the University of São Paulo Medical School, Brazil. ecg_pastore@incor.usp.br
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Pastore
authors.forename: Nancy
authors.initials: N
authors.lastname: Tobias
authors.forename: Nelson
authors.initials: N
authors.lastname: Samesima
authors.forename: Martino Martinelli
authors.initials: MM
authors.lastname: Filho
authors.forename: Anisio
authors.initials: A
authors.lastname: Pedrosa
authors.forename: Silvana
authors.initials: S
authors.lastname: Nishioka
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Douglas
authors.forename: Luís Felipe
authors.initials: LF
authors.lastname: Moreira
authors.forename: José Franchini
authors.initials: JF
authors.lastname: Ramires
mesh_terms: D000328:Adult; D000368:Aged; D018780:Body Surface Potential Mapping; D002037:Bundle-Branch Block / Q000503:physiopathology* / Q000628:therapy; D002304:Cardiac Pacing, Artificial; D005260:Female; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D016276:Ventricular Function / Q000502:physiology