Primary anaplastic large cell lymphoma of central nervous system--a case report.
Central nervous system (CNS) involvement is extremely rare in anaplastic large cell lymphoma (ALCL). Primary ALCL of CNS on radiology is often misdiagnosed as tuberculosis. We report a fatal case of primary ALCL of CNS in a 17 year old male. He came with history of headache and left partial seizures. MRI showed a well- circumscribed lesion in the right fronto-parietal lobe eroding the skull bone. Biopsy showed large pleomorphic cells. Immunohistochemical stains showed positivity for CD30, CD43, EMA and ALK-1. In spite of radiotherapy and steroids, patient expired. Hence a high level of suspicion is essential for early diagnosis and for instituting appropriate treatment.
Rupani
A
A
Department of Pathology, T. N. Medical College, B. Y. L. Nair Charitable Hospital, Mumbai, India. asharupani@yahoo.com
Modi
C
C
Desai
S
S
Rege
J
J
D000293:Adolescent; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000628:therapy; D003951:Diagnostic Errors; D017809:Fatal Outcome; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D014376:Tuberculosis / Q000175:diagnosis