title: A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.
abstract: JASPAR is the most complete open-access collection of transcription factor binding site (TFBS) matrices. In this new release, JASPAR grows into a meta-database of collections of TFBS models derived by diverse approaches. We present JASPAR CORE--an expanded version of the original, non-redundant collection of annotated, high-quality matrix-based transcription factor binding profiles, JASPAR FAM--a collection of familial TFBS models and JASPAR phyloFACTS--a set of matrices computationally derived from statistically overrepresented, evolutionarily conserved regulatory region motifs from mammalian genomes. JASPAR phyloFACTS serves as a non-redundant extension to JASPAR CORE, enhancing the overall breadth of JASPAR for promoter sequence analysis. The new release of JASPAR is available at http://jaspar.genereg.net.
authors.affiliation: Department for Molecular Biomedical Research (DMBR), VIB-Ghent University, Technologiepark 927 B-9052, Ghent (Zwijnaarde), Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Vlieghe
authors.forename: Albin
authors.initials: A
authors.lastname: Sandelin
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: De Bleser
authors.forename: Kris
authors.initials: K
authors.lastname: Vleminckx
authors.forename: Wyeth W
authors.initials: WW
authors.lastname: Wasserman
authors.forename: Frans
authors.initials: F
authors.lastname: van Roy
authors.forename: Boris
authors.initials: B
authors.lastname: Lenhard
mesh_terms: D000818:Animals; D001665:Binding Sites; D019295:Computational Biology; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D030561:Databases, Nucleic Acid; D023281:Genomics; D020407:Internet; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D014157:Transcription Factors; D004247:DNA