title: Regulation of CD 38 expression and function by steroid hormones in myometrium.
abstract: CD 38, a 45-kDa transmembrane glycoprotein, is expressed ubiquitously in many cell types, including the myometrial smooth muscle cells. CD 38 is a bifunctional protein, and has both ADP-ribosyl cyclase (cyclase) and cyclic ADP-ribose (cADPR)-hydrolase (hydrolase) activities. The cyclase converts beta-NAD to cADPR, a calcium mobilizing second messenger involved in fertilization, insulin secretion, and muscle contraction. CD 38 expression in smooth muscle is regulated by cytokines, by the steroid hormones estrogen and progesterone, and during gestation in the rat. Estrogen increases CD 38 expression, which is associated with increased cyclase, but not hydrolase, activity, indicating a differential post-translational regulation. Progesterone attenuates estrogen-induced effects on CD 38 expression and activities. This will have implications for increased calcium mobilization and contractility of the myometrium during parturition.
authors.affiliation: Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA.
authors.forename: Soner
authors.initials: S
authors.lastname: Dogan
authors.forename: Deepak A
authors.initials: DA
authors.lastname: Deshpande
authors.forename: Thomas A
authors.initials: TA
authors.lastname: White
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Walseth
authors.forename: Mathur S
authors.initials: MS
authors.lastname: Kannan
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism*; D000818:Animals; D004967:Estrogens / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D008954:Models, Biological; D009215:Myometrium / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology / Q000502:physiology; D051381:Rats
chemical_list: D004967:Estrogens; D011374:Progesterone; D051997:ADP-ribosyl Cyclase 1