Therapeutic drug monitoring assay development to improve efficacy and safety.
The development of therapeutic drug management (TDM) utilizing diagnostic assays as biomarker tests is described. TDM can be useful in establishing an individual patient's optimal blood concentration range, and benchmarking blood concentrations at which seizures are controlled, as well as those associated with AED-specific adverse effects. TDM requires the application of pharmacokinetic, pharmacodynamic, pharmacogenomic, pathophysiological and clinical principles to the management of patients in order to achieve safe and effective therapy. Optimal therapy requires rational application of all these principles to personalize patient care.
Pippenger
Charles E
CE
D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood*; D016903:Drug Monitoring / Q000266:history / Q000379:methods*; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D049673:History, 20th Century; D006801:Humans
D000927:Anticonvulsants