Cytotoxic lignans from the stems of Helicteres hirsuta collected in Indonesia.
Cytotoxicity-guided fractionation of the stems of Helicteres hirsuta, of Indonesian origin, led to the isolation and identification of six lignans, namely, (+/-)-pinoresinol, (+/-)-medioresinol, (+/-)-syringaresinol, (-)-boehmenan, (-)-boehmenan H and (+/-)-trans-dihydrodiconiferyl alcohol. Of these isolates, (+/-)-pinoresinol exhibited potent cytotoxic effects when evaluated against a small panel of cancer cell lines.
Chin
Young-Won
YW
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Jones
William P
WP
Rachman
Ismail
I
Riswan
Soedarsono
S
Kardono
Leonardus B S
LB
Chai
Hee-Byung
HB
Farnsworth
Norman R
NR
Cordell
Geoffrey A
GA
Swanson
Steven M
SM
Cassady
John M
JM
Kinghorn
A Douglas
AD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D007214:Indonesia; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D019660:Malvaceae / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D018675:Toxicity Tests
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans