[Hira gene and development: from yeast to human].
HIR/HIRA, one of the histone chaperones, encoded by Hir/Hira (histone regulation) genes, were initially identified in yeast as negative regulators of histone gene expression. It has been confirmed that HIRA contains a conserved family of proteins found in various species including low eukaryotes, invertebrates and vertebrates. It is essential for proper development. Mutations of Hir/Hira genes result in very serious defects in normal development not only in yeast but also in advanced eukaryotes. Combined with the work in our group, the roles of Hir/Hira genes in the development in different species are reviewed, and the recent advances concerning the mechanisms of HIRA functioning are also summarized in an attempt to promote the research further on the exact roles of hira genes in development of eukaryotes and on their deeply operating mechanisms.
Wang
Yu-Feng
YF
College of Life Science, Central China Normal University, Wuhan 430079, China. yfengw@public.wh.hb.cn
Du
Xin-Zheng
XZ
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D004062:DiGeorge Syndrome / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D056488:Histone Chaperones; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D018797:Cell Cycle Proteins; C078808:HIR1 protein, S cerevisiae; C078809:HIR2 protein, S cerevisiae; C086057:HIRA protein, human; C484187:Hira protein, mouse; D056488:Histone Chaperones; D009687:Nuclear Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors