Daily profile of plasma %CoQ10 level, a biomarker of oxidative stress, in patients with diabetes manifesting postprandial hyperglycaemia.
The purpose of this study was to investigate the effect of regular meals on the daily profile of blood oxidative stress markers in type 2 diabetic patients with postprandial hyperglycaemia. %CoQ10, calculated as the ratio of ubiquinone-10 (oxidised form of coenzyme Q10) to ubiquinol-10 (reduced form), was used as a sensitive marker of oxidative stress. Blood samples were collected from patients before and 2 h after breakfast, lunch and supper, and at 10 p.m. Patients were selected for the study if their blood glucose levels were <7 mmol/l before breakfast and > or =11.1 mmol/l on at least one occasion after breakfast. %CoQ10 levels after breakfast and throughout the day were significantly higher than those before breakfast (p=0.006-0.04). In contrast to the wave-like changes in plasma glucose levels, %CoQ10 levels increased after breakfast and remained at high levels throughout the day. These results indicated that diabetic patients with postprandial hyperglycaemia were exposed to meal-induced periods of oxidative stress during the day. Postprandial hyperglycaemia therefore has the potential to increase the risk of atherosclerotic cardiovascular disease through induction of oxidative stress.
Hasegawa
G
G
Department of Endocrinology and Metabolism, Kyoto Prefectural University, Medicine Graduate School of Medical Science, Hirokoji, Kawaramachi-dori, Kamikyo-ku, Japan. goji@koto.kpu-m.ac.jp
Yamamoto
Y
Y
Zhi
J G
JG
Tanino
Y
Y
Yamasaki
M
M
Yano
M
M
Nakajima
T
T
Fukui
M
M
Yoshikawa
T
T
Nakamura
N
N
D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003067:Coenzymes; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D018384:Oxidative Stress; D018579:Patient Selection; D019518:Postprandial Period; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D003067:Coenzymes; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10; D001205:Ascorbic Acid