Effects of the intraperitoneal lornoxicam on the formation of intraperitoneal adhesions in rat peritonitis model.
BACKGROUND
To investigate the effects of intraperitoneally administered lornoxicam on adhesion formation, bursting pressure, tissue antioxidant levels, morbidity and mortality after ileocolic anastomosis in a rat bacterial peritonitis model.


METHODS
Thirty-six rats were divided into three random groups. Bacterial peritonitis was induced by performing a cecal ligation and puncture, then the cecal was resected and ileocolic anastomosis was performed. Rats of groups 1, 2 and 3 were given 2 mL normal saline, 2 mL lornoxicam, and nothing, respectively. All groups were killed at day 14. Adhesions were scored, and the presence of intra-abdominal abscesses and fistulas were noted. Anastomotic healing was assessed by bursting pressure. Tissue antioxidant levels were tested from left abdominal walls.


RESULTS
One day after cecal ligation and puncture, microbiological examination showed polymicrobial bacterial peritonitis. The rats treated with lornoxicam had significantly lower adhesion scores than did the saline and nothing treated rats (P = 0.007). Bursting pressures of groups were unaffected by the treatment. Tissue antioxidant levels of groups were affected by the treatment. Morbidity and mortality were similar in all groups.


CONCLUSIONS
The present study demonstrated that a single intraperitoneal instillation of lornoxicam in buffer solution at the end of the surgery reduces adhesion formation in rats bacterial peritonitis model. It was also determined that lornoxicam had no negative effect on the healing of intestinal anastomosis, abscess and anastomotic leakage. Use of lornoxicam in peritonitis was effective in decreasing the oxidative stress of tissue during peritonitis.
Bulbuloglu
Ertan
E
Department of Surgery, University of Kahramanmaras, Faculty of Medicine, Kahramanmaras, Turkey. ertanbulbuloglu@mynet.com
Ezberci
Fikret
F
Gul
Mustafa
M
Kurutas
Ergul Belge
EB
Bozkurt
Serdar
S
Kale
I Taner
IT
Ciragil
Pinar
P
D000714:Anastomosis, Surgical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D018384:Oxidative Stress; D010538:Peritonitis / Q000601:surgery*; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011183:Postoperative Complications / Q000517:prevention & control*; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C059451:lornoxicam