title: History and recent advances in coronavirus discovery.
abstract: Human coronaviruses, first characterized in the 1960s, are responsible for a substantial proportion of upper respiratory tract infections in children. Since 2003, at least 5 new human coronaviruses have been identified, including the severe acute respiratory syndrome coronavirus, which caused significant morbidity and mortality. NL63, representing a group of newly identified group I coronaviruses that includes NL and the New Haven coronavirus, has been identified worldwide. These viruses are associated with both upper and lower respiratory tract disease and are likely common human pathogens. The global distribution of a newly identified group II coronavirus, HKU1, has not yet been established. Coronavirology has advanced significantly in the past few years. The SARS epidemic put the animal coronaviruses in the spotlight. The background and history relative to this important and expanding research area are reviewed here.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA. jeffrey.kahn@yale.edu
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Kahn
authors.forename: Kenneth
authors.initials: K
authors.lastname: McIntosh
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D021821:Communicable Diseases, Emerging / Q000266:history; D017934:Coronavirus / Q000145:classification* / Q000302:isolation & purification* / Q000472:pathogenicity; D028941:Coronavirus 229E, Human / Q000302:isolation & purification / Q000472:pathogenicity; D018352:Coronavirus Infections / Q000453:epidemiology / Q000266:history* / Q000821:virology; D005260:Female; D049673:History, 20th Century; D006801:Humans; D007223:Infant; D008297:Male; D045473:Severe acute respiratory syndrome-related coronavirus / Q000302:isolation & purification / Q000472:pathogenicity; D045169:Severe Acute Respiratory Syndrome