Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia.
BACKGROUND
Patients with schizophrenia show deficits in facial affect and facial identity recognition and exhibit structural and neurophysiological abnormalities in brain regions known to mediate these processes. Functional neuroimaging studies of neural responses to emotional facial expressions in schizophrenia have reported both increases and decreases in medial temporal lobe (MTL) activity in schizophrenia. Some of this variability may be related to the tasks performed and the baseline conditions used. Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition.


METHODS
15 patients with schizophrenia and 16 healthy control subjects underwent functional magnetic resonance imaging (fMRI) while passively viewing human faces displaying fearful, happy, and neutral emotional expressions.


RESULTS
Relative to control subjects, the patients demonstrated (1) significantly greater activation of the left hippocampus while viewing all three facial expressions and (2) increased right amygdala activation during the initial presentation of fearful and neutral facial expressions.


CONCLUSIONS
In schizophrenia, hippocampal and amygdala activity is elevated during the passive viewing of human faces.
Holt
Daphne J
DJ
Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA. dholt@partners.org
Kunkel
Laura
L
Weiss
Anthony P
AP
Goff
Donald C
DC
Wright
Christopher I
CI
Shin
Lisa M
LM
Rauch
Scott L
SL
Hootnick
Jessica
J
Heckers
Stephan
S
D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005239:Fear / Q000502:physiology; D006240:Happiness; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000503:physiopathology*