title: Neurodegenerative diseases: a common etiology and a common therapy.
abstract: The variety of names of neurodegenerative diseases (NDDs) does not indicate that there is a wide variety of causes and a multiple number of cures. In fact NDDs derive from a common and repetitive, almost monotonous multicausal origin. NDDs are initiated invariably by a sudden or silent insidious decrease in immunologic resistance of the T cell-dependent or delayed type, produced by a large variety of psychological-emotional and/or environmental "stressors" (e.g., social, family-domestic, economic, alimentary, traumatic, and professional). These stressors increase the vulnerability of tissues (in this case, a section of the central or peripheral nervous system) to attack by a common virus (e.g., adenoviruses and herpesviruses). This attack creates a vicious circle leading to emergence of virus-generated tissue autoantigens and then to formation of autoantibodies. Use of corticosteroids and immunosuppressive drugs dramatically worsen and "eternalize" the diseases with further immunosuppression. Invariably, onset of NDDs is anticipated by a clear-cut alteration of the hormonal cyclicity, which closely controls immunity. My experience with patients in the last five years indicates a new approach to prevent and cure NDDs, based on a system totally divergent from present therapies. In fact "resetting the hormonal cyclicity clock" results in restoration of hormone-dependent antiviral immunity, arrest of disease progression, and at least partial recovery of neural functions, whatever the origin, anatomic location, and course of pathology.
authors.affiliation: Walter Pierpaoli Foundation of Life Sciences, Orvieto, Italy. pierpaoli.fnd@bluewin.ch
authors.forename: Walter
authors.initials: W
authors.lastname: Pierpaoli
mesh_terms: D006801:Humans; D007165:Immunosuppression Therapy; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D015213:Neuroimmunomodulation