Rifampin augments cytokine-induced nitric oxide production in human alveolar epithelial cells.
Rifampin increased nitric oxide production and inducible nitric oxide synthase expression in alveolar cells stimulated with cytokines. Nitric oxide concentrations after induction with cytokines, cytokines with 10 microg/ml rifampin, and cytokines with 50 microg/ml rifampin were 3.2, 4.5, and 8.8 microM, respectively (P < 0.02 versus cytokines alone). This indicates that rifampin modulates the immune response.
Yuhas
Yael
Y
Laboratory of Infectious Diseases, Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva 49100, Israel. yuhas@post.tau.ac.il
Berent
Eva
E
Ovadiah
Hila
H
Azoulay
Inbar
I
Ashkenazi
Shai
S
D016207:Cytokines / Q000378:metabolism*; D004790:Enzyme Induction; D004847:Epithelial Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000166:cytology; D012293:Rifampin / Q000494:pharmacology*
D016207:Cytokines; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D012293:Rifampin