An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media.
The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release properties. Samples were characterized by measuring the swelling behavior and in vitro release of paracetamol as a model drug in aqueous media with different pH values. The two-factor, three-level experimental design and response surface methodology were applied to statistically evaluate the influence of investigated factors.
Stanojević
Marija
M
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro. marija@pharmacy.bg.ac.yu
Krusić
Melina Kalagasidis
MK
Filipović
Jovanka
J
Parojcić
Jelena
J
Stupar
Mirjana
M
D000180:Acrylic Resins / Q000737:chemistry*; D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers; D012044:Regression Analysis; D013386:Succinates / Q000737:chemistry*; D000099166:Polyacrylamides
D000180:Acrylic Resins; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D011108:Polymers; D013386:Succinates; D000099166:Polyacrylamides; C005229:itaconic acid