A missing sugar prevents glucose entry: a new twist on insulin secretion.
The signaling pathway that regulates glucose-stimulated insulin secretion depends on glucose metabolism, which is itself controlled by glucokinase. In a recent issue of Cell, show that altering N-glycosylation of the GLUT2 glucose transporter prevents its anchoring and retention at the cell surface; this impairs glucose uptake and insulin secretion.
Thorens
Bernard
B
Department of Physiology and Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015 Lausanne, Switzerland.
D000818:Animals; D037161:Galectins / Q000378:metabolism; D005947:Glucose / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051273:Glucose Transporter Type 2 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D051379:Mice; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics / Q000378:metabolism
D037161:Galectins; D051273:Glucose Transporter Type 2; D007328:Insulin; C105032:LGALS9 protein, human; D017351:N-Acetylglucosaminyltransferases; C038111:alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase; D005947:Glucose