title: Unclassified rhabdomyosarcoma in a patient with anti-Hu syndrome.
abstract: Anti-Hu syndrome is a paraneoplastic neurological syndrome, most frequently associated with small cell carcinoma of the lung. Subacute sensory neuronopathy is thought to be the most frequent presentation of the anti-Hu syndrome, but it seems that sensory-motor neuropathy is the most common form in the anti-Hu neuropathy. Neurological symptoms often appear before the associated cancer has been identified. Sometimes the tumor is discovered months or even a few years after the appearance of the neurological syndrome. FDG-PET scan seems a better method for finding the tumor in patients with paraneoplastic neurological syndrome and anti-Hu antibodies who had negative test results after an initial workup using radiological methods. In this case report we present a patient with the anti-Hu syndrome associated with an unclassified rhabdomyosarcoma with epitheloid cellular morphology and neuroendocrine differentiation.
authors.affiliation: Dienst longziekten, Academisch Ziekenhuis Maastricht. alexandraschilstra@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Schilstra
authors.forename: J H
authors.initials: JH
authors.lastname: van Tuijl
authors.forename: R J
authors.initials: RJ
authors.lastname: van Suylen
authors.forename: C G
authors.initials: CG
authors.lastname: Faber
authors.forename: G P M
authors.initials: GP
authors.lastname: ten Velde
mesh_terms: D000368:Aged; D051959:ELAV Proteins / Q000276:immunology*; D006801:Humans; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000150:complications / Q000276:immunology*; D012208:Rhabdomyosarcoma / Q000150:complications*; D013899:Thoracic Neoplasms / Q000150:complications* / Q000473:pathology
chemical_list: D051959:ELAV Proteins