title: Flow mediated dilatation and cardiac function in type 1 diabetes mellitus.
abstract: The present study sought to examine the occurrence of subclinical markers of cardiovascular risk and cardiac dysfunction with increasing disease duration in type 1 diabetes mellitus (DM). There are few data on subclinical cardiovascular abnormalities in type 1 DM. The study included 100 patients without any cardiovascular complaints (mean age 46.6 years, range 22 to 63), with a history of type 1 DM ranging from 2 to 36 years, and 75 age-matched controls. Standard 2-dimensional and Doppler echocardiography and pulse-wave tissue Doppler (tD) mapping of systolic (Sm) and diastolic (Em, Am) velocities (12 left ventricular [LV] segments and right-sided cardiac) were performed. An Em/Am ratio of <1 was considered to represent abnormal segmental diastolic function. Flow-mediated dilation (FMD) of the brachial artery, carotid intima media thickness (IMT) measurement, and extensive laboratory analysis were performed. The FMD was reduced, and IMT increased in patients (p < 0.01). Regional tD-derived diastolic and systolic functional abnormalities were observed within the first decade of the disease. Significant correlations were found between FMD and LV segments with tD-derived dysfunction, the duration of DM, and fibrinogen (p < 0.0001 for all). Stepwise regression analysis showed that FMD was the strongest predictor of abnormal segmental function (p < 0.0001). Data further presented as an analysis of tertiles by DM duration show an increasing occurrence of subclinical cardiac dysfunction and cardiovascular risk markers compared with age-matched controls. In conclusion, FMD is associated with abnormal segmental cardiac function in type 1 DM.
authors.affiliation: Department of Cardiology, University Hospital Antwerp, Edegem, Belgium. bharati.shivalkar@skynet.be
authors.forename: Bharati
authors.initials: B
authors.lastname: Shivalkar
authors.forename: Dominique
authors.initials: D
authors.lastname: Dhondt
authors.forename: Inge
authors.initials: I
authors.lastname: Goovaerts
authors.forename: Luc
authors.initials: L
authors.lastname: Van Gaal
authors.forename: Josef
authors.initials: J
authors.lastname: Bartunek
authors.forename: Paul
authors.initials: P
authors.lastname: Van Crombrugge
authors.forename: Christiaan
authors.initials: C
authors.lastname: Vrints
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D013599:Systole / Q000502:physiology; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014664:Vasodilation / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D005340:Fibrinogen; D006442:Glycated Hemoglobin