title: Antidiarrhoeal evaluation of Aegle Marmelos (Correa) Linn. root extract.
abstract: A study was undertaken to evaluate the in vitro and in vivo antidiarrhoeal potential of chloroform extract of the root of Aegle marmelos (Correa) Linn. The in vitro activity was determined by agar dilution and disc diffusion techniques. The extract was studied in vivo in rats. Of the 35 tested pathogenic diarrhoea causing strains, the extract was found to be mostly active against the strains of Vibrio cholerae, followed by Escherichia coli and Shigella spp. The in vitro activity was found to be comparable to that of ciprofloxacin. Further, Aegle marmelos root extract (AMRE) treated animals showed significant inhibitory activity against castor oil-induced diarrhoea. The results so obtained thus established the efficacy of AMRE as an effective antidiarrhoeal agent.
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India. rupa_mazumder@rediffmail.com
authors.forename: R
authors.initials: R
authors.lastname: Mazumder
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Avijit
authors.initials: A
authors.lastname: Mazumder
authors.forename: A K
authors.initials: AK
authors.lastname: Pattnaik
authors.forename: P M
authors.initials: PM
authors.lastname: Tiwary
authors.forename: S
authors.initials: S
authors.lastname: Chaudhary
mesh_terms: D045471:Aegle / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000930:Antidiarrheals / Q000494:pharmacology* / Q000627:therapeutic use; D002368:Castor Oil / Q000008:administration & dosage / Q000633:toxicity; D002939:Ciprofloxacin / Q000494:pharmacology; D015169:Colony Count, Microbial / Q000379:methods; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D008297:Male; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012760:Shigella / Q000187:drug effects; D014734:Vibrio cholerae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000930:Antidiarrheals; D010936:Plant Extracts; D002939:Ciprofloxacin; D002368:Castor Oil