Nonsurgical treatment of patent arterial duct in term neonates with congenital heart disease: the role of intravenous indomethacin.
We present two term neonates in which intravenous indomethacin usage was associated with successful closure of a persistently patent arterial duct. Both children had congenital heart disease with high pulmonary blood flow following surgical placement of contralateral systemic-pulmonary artery shunts.
Vandekerckhove
K
K
Paediatric Intensive Care Unit, Royal Brompton Hospital, Royal Brompton & Harefield NHS Trust, Sydney Street, London SW3 6NP, UK.
Macrae
D
D
Slavik
Z
Z
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D006330:Heart Defects, Congenital / Q000188:drug therapy; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D008297:Male; D014694:Ventricular Outflow Obstruction / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin