title: Triplex formation with alpha-L-LNA (alpha-L-ribo-configured locked nucleic acid).
abstract: Using UV melting and CD spectroscopy, we show that alpha-l-LNA-modified oligonucleotides possess the ability to form triplexes at pH 6.8 with significantly increased thermostability relative to DNA triplexes.
authors.affiliation: Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
authors.forename: Niti
authors.initials: N
authors.lastname: Kumar
authors.forename: Katrine E
authors.initials: KE
authors.lastname: Nielsen
authors.forename: Souvik
authors.initials: S
authors.lastname: Maiti
authors.forename: Michael
authors.initials: M
authors.lastname: Petersen
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D019906:Nuclear Magnetic Resonance, Biomolecular; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D009841:Oligonucleotides; C051802:triplex DNA; D004247:DNA