title: Effects of acute preload reduction on myocardial velocity during isovolumic contraction and myocardial acceleration in pediatric patients.
abstract: We evaluated the effects of acute preload reduction with inferior vena cava (IVC) occlusion on myocardial velocities during systole (Sa), early (Ea) and late (Aa) diastole, isovolumic contraction (IVV), and myocardial acceleration (IVA) measured by tissue Doppler imaging (TDI) in pediatric patients. A total of 22 patients (5 +/- 3 years) were studied: 9 patients (4 +/- 3 years) with Kawasaki disease, 8 patients (6 +/- 3 years) with atrial septal defect and right ventricular (RV) volume overload, and 5 patients (5 +/- 4 years) with pulmonary stenosis and RV pressure overload. Using TDI, Sa, Ea, Aa, IVV were recorded at the base of the RV free wall from a four-chamber view. IVA was calculated by dividing IVV by the time interval from onset of IVV to the time at peak velocity of this wave. In each group, IVC occlusion caused significant decreases in peak Sa, peak Ea, and peak Aa (p < 0.05). However, IVV and IVA did not change during acute preload reduction. This study demonstrated the effects of acute preload reduction on TDI velocities. In contrast to peak Sa, peak Ea, and peak Aa, IVV and IVA were unaffected by preload within a physiological range.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan. duanyuqing@sohu.com.
authors.forename: Y Yuqing
authors.initials: YY
authors.lastname: Duan
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Toyono
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishii
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Takada
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D015150:Echocardiography, Doppler; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology*; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology*; D011666:Pulmonary Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D012016:Reference Values; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging / Q000503:physiopathology; D016278:Ventricular Function, Right / Q000502:physiology