title: Gender differences in handedness and speech lateralization related to early neurologic insults.
abstract: Left-handedness is a normal variant but also may result from early-life brain insults. Speech typically resides in the left cerebral hemisphere in normal subjects. In 170 subjects with past brain injuries, bilateral or right hemisphere speech lateralization, determined by the intracarotid amobarbital procedure, was more frequent in females (19 vs 5, p = 0.003) as was left-handedness (26 vs 10, p = 0.004). This could be attributed to greater plasticity or functional symmetry in females.
authors.affiliation: The Regional Epilepsy Center, Harborview Medical Center, Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. millerjw@u.washington.edu
authors.forename: John W
authors.initials: JW
authors.lastname: Miller
authors.forename: Suman
authors.initials: S
authors.lastname: Jayadev
authors.forename: Carl B
authors.initials: CB
authors.lastname: Dodrill
authors.forename: George A
authors.initials: GA
authors.lastname: Ojemann
mesh_terms: D000367:Age Factors; D000654:Amobarbital; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000254:growth & development / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007807:Language Tests; D008297:Male; D019957:Motor Skills Disorders / Q000209:etiology / Q000503:physiopathology; D009434:Neural Pathways / Q000254:growth & development / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology*; D012727:Sex Characteristics; D013060:Speech / Q000502:physiology*
chemical_list: D000654:Amobarbital