Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia.
To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N=186), frontotemporal dementia (FTD) (N=29), mixed dementia (MXD) (N=28), dementia with Lewy bodies (DLB) (N=11) and Parkinson's disease dementia (PDD) (N=7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)). In FTD patients, we identified dose dependent effects of APOE epsilon4 on the Behave-AD total and cluster aggressiveness scores. APOE epsilon2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD patients were found. In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon4 with aggression (FTD) and of APOE epsilon2 with delusions (PDD/DLB).
Engelborghs
Sebastiaan
S
Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium.
Dermaut
Bart
B
Mariën
Peter
P
Symons
Anoek
A
Vloeberghs
Ellen
E
Maertens
Karen
K
Somers
Nore
N
Goeman
Johan
J
Rademakers
Rosa
R
Van den Broeck
Marleen
M
Pickut
Barbara
B
Cruts
Marc
M
Van Broeckhoven
Christine
C
De Deyn
Peter P
PP
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics / Q000473:pathology; D000704:Analysis of Variance; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001526:Behavioral Symptoms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D003704:Dementia / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D003710:Demography; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D008875:Middle Aged
D053327:Apolipoprotein E4; D001057:Apolipoproteins E