Serum lipoproteins: Trojan horses of the immune response?
T cells recognizing lipid antigens presented by CD1 molecules have an important role in the immune response. Several lipid antigens for CD1-restricted T cells have been identified, as have some rules of CD1 loading and CD1-restricted presentation. Little is known, however, about the delivery of lipid antigens from either extracellular compartments or CD1-negative cells to CD1-expressing antigen-presenting cells (APCs). A recent study provides evidence for a role for apolipoprotein E in binding lipid antigens and delivering them to APCs.
Schümann
Jens
J
Experimental Immunology, Department of Research, University Hospital, Basel, Switzerland.
De Libero
Gennaro
G
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D008055:Lipids / Q000276:immunology; D008074:Lipoproteins / Q000097:blood* / Q000276:immunology*; D014611:Vaccination
D000941:Antigens; D008055:Lipids; D008074:Lipoproteins