Gene polymorphisms in patients below 35 years of age who underwent coronary artery bypass surgery.
OBJECTIVE
Genetic bases for novel prothrombotic, inflammatory risk factors may play a role in the early onset of coronary artery disease.


METHODS
Twenty-one patients below 35 years of age who underwent coronary bypass grafting between 2002 and 2004 constituted the study group and were compared with 50 healthy, age and sex-matched controls. Gene analysis for genetic polymorphisms of angiotensin-converting enzyme, prothrombin G20210A, tumour necrosis factor-alpha G308A, factor V Leiden and interleukin-6 genes was carried out.


RESULTS
The control group was 98% homozygous for the factor V Leiden GG allele and 2% heterozygous for the GA allele. On the other hand, the study group was 76.2% homozygous for the GG allele, and 23.8% heterozygous for the GA allele (P<0.05). Homozygosity for factor V Leiden mutation (AA) was not encountered in either group. With regard to interleukin-6, 70.0% of the control group demonstrated homozygosity for the GG allele and 30.0% showed heterozygosity (GC). The study group was 52.4% homozygous for the GG allele and heterogenicity was similar in this group (28.6% GC). On the other hand, 19.0% of this group demonstrated CC homogenicity (P<0.05). No difference was observed with regard to gene polymorphisms.


CONCLUSIONS
Gene polymorphisms with regard to prothrombotic factor V Leiden mutation and inflammatory marker interleukin-6 may play a role in the pathogenesis of early-onset coronary artery stenosis in patients below 35 years of age.
Tütün
Ufuk
U
Cardiovascular Surgery Clinic, Türkiye Yüksek Ihtisas Hospital, Turkey. ufuktutun@yahoo.com
Aksöyek
Ayşen
A
Ulus
Ahmet Tulga
AT
Misirlioğlu
Müge
M
Ciçekçioğlu
Ferit
F
Ozişik
Kanat
K
Ihsan Parlar
Ali
A
Baran Budak
Ali
A
Gedik
Selçuk
S
Katircioğlu
Salih Fehmi
SF
D000328:Adult; D000367:Age Factors; D000483:Alleles; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000235:genetics* / Q000601:surgery; D004247:DNA / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005165:Factor V / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D011379:Prognosis; D011516:Prothrombin / Q000235:genetics; D012189:Retrospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D005819:Genetic Markers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D004247:DNA; D007703:Peptidyl-Dipeptidase A