Hyperprolinemia is not associated with childhood onset schizophrenia.
In a previous report [Jacquet et al., 2005] we have shown that mild to moderate hyperprolinemia resulting from several alterations (either a complete deletion or missense mutations) of the proline dehydrogenase (PRODH) gene located on chromosome 22q11 is a risk factor for schizoaffective disorder but not for DSM3 R schizophrenia or bipolar disorder. We now report that hyperprolinemia is not associated with childhood onset schizophrenia (COS).
Jacquet
Hélène
H
INSERM U 614, Faculté de Médecine, Rouen, France.
Rapoport
Judith L
JL
Hecketsweiler
Bernadette
B
Bobb
Aaron
A
Thibaut
Florence
F
Frébourg
Thierry
T
Campion
Dominique
D
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D011392:Proline / Q000097:blood*; D011394:Proline Oxidase / Q000235:genetics* / Q000378:metabolism; D012559:Schizophrenia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*
D011392:Proline; D011394:Proline Oxidase