SAPHO syndrome treated with pamidronate.
A middle aged man presented with a 4 year history of painful swelling of both knees and pustular acne on his back. The MRI scan of the knees showed gross synovitis, so did the histopathology of the synovium. A diagnosis of SAPHO syndrome was made and he was treated with IV pamidronate. His pain reduced and acne completely cleared up on therapy. A dermatologist has rarely made a diagnosis of SAPHO syndrome and treated it.
Tehrani
Rustom
R
Mallya Hospital, Bangalore, India. rustomtehrani@yahoo.co.in
D020083:Acquired Hyperostosis Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D008279:Magnetic Resonance Imaging; D008297:Male; D000077268:Pamidronate; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate