title: Effect of axial length on laser spot size during photodynamic therapy: an experimental study in monkeys.
abstract: OBJECTIVE
  To investigate the effect of shorter axial length on the laser spot size and laser energy during photodynamic therapy (PDT) in monkeys.
  
  
  METHODS
  Experimental study with four rhesus monkeys.
  
  
  METHODS
  PDT was performed on the normal retina of monkeys whose ocular axial lengths are shorter (19.55 to 20.25 mm) than that of humans. After the PDT, the eyes were enucleated, and the diameter of the irradiated laser spot was measured with a microcaliper.
  
  
  RESULTS
  The area of actual laser spot was only 0.56 to 0.61 times of the planned area, which indicated that the laser energy/area was 1.64 to 1.78 times more intense than planned initially.
  
  
  CONCLUSIONS
  These results are the in vivo demonstration that the diameter of PDT laser spot is smaller for eyes with shorter axial lengths.
authors.affiliation: Department of Ophthalmology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan. kondomi@med.nagoya-u.ac.jp
authors.forename: Mineo
authors.initials: M
authors.lastname: Kondo
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Ito
authors.forename: Kentaro
authors.initials: K
authors.lastname: Miyata
authors.forename: Nagako
authors.initials: N
authors.lastname: Kondo
authors.forename: Kohei
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Terasaki
mesh_terms: D000818:Animals; D000886:Anthropometry; D005123:Eye / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D007834:Lasers / Q000009:adverse effects*; D008253:Macaca mulatta; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011166:Porphyrins / Q000008:administration & dosage; D012160:Retina / Q000293:injuries* / Q000473:pathology; D014463:Ultrasonography; D000077362:Verteporfin
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin