Acute eosinophilic pneumonia after allogeneic hematopoietic stem cell transplantation.
A 55-year old woman with multiple myeloma was treated with hematopoietic stem cell transplantation (HSCT). She developed cutaneous and hepatic graft-vs-host disease (GVHD). Sixty-five days after HSCT, acute respiratory failure occurred. A thoracic computed tomography scan showed bilateral patchy infiltrates. Bronchoalveolar lavage revealed 40% eosinophils on differential cell count with no infectious pathogens. These findings were in favor of acute eosinophilic pneumonia. High-dose steroid treatment was started, which had a rapid and lasting favorable course. After HSCT, clinicians should be aware that acute eosinophilic pneumonia mimics infectious pneumonitis and can be associated with GVHD.
Wagner
Thierry
T
Dhedin
Nathalie
N
Philippe
Bruno
B
Rivaud
Elisabeth
E
Vernant
Jean Paul
JP
Couderc
Louis-Jean
LJ
D000208:Acute Disease; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D011657:Pulmonary Eosinophilia / Q000000981:diagnostic imaging / Q000209:etiology; D011859:Radiography; D014184:Transplantation, Homologous