Managing the failing allograft.
Managing the failing allograft juxtaposes immunosuppressive management and routine chronic kidney disease care. The complications of immunosuppression can be more pronounced in those with renal failure (infection, anemia, bone disease). The withdrawal of immunosuppression may be associated with acute allograft rejection, arthralgias, and the development of antidonor antibodies. Likewise depression is prevalent. Improving well-being and overall survival necessitates proper titration of immunosuppressive medications and control of blood pressure, anemia, lipids, and glucose along with attention to treatment of depression.
Kendrick
Elizabeth A
EA
Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, Washington, USA.
Davis
Connie L
CL
D006084:Graft Rejection / Q000473:pathology* / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation / Q000276:immunology / Q000473:pathology* / Q000523:psychology; D014184:Transplantation, Homologous