Cytotoxic activity of some natural and synthetic sesquiterpene lactones.
Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane, heliangolane and their hydroxy analogues 9 and 10, all containing an alpha,beta-unsaturated aldehyde substituent, were the most potent compounds.
Bruno
Maurizio
M
Dipartimento di Chimica Organica, Università di Palermo, Palermo, Italy. bruno@dicpm.unipa.it
Rosselli
Sergio
S
Maggio
Antonella
A
Raccuglia
Rosa Angela
RA
Bastow
Kenneth F
KF
Wu
Chin-Chung
CC
Lee
Kuo-Hsiung
KH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D045744:Cell Line, Tumor; D031179:Centaurea / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D007783:Lactones; D012717:Sesquiterpenes