title: Morphologic evidence of subclinical atherosclerosis obtained by carotid ultrasonography in patients with Behcet's disease.
abstract: Subclinical atherosclerosis can be demonstrated by measuring the intima-media thickness (IMT) of the carotid arteries by high-resolution B-mode ultrasonography (US). Endothelial injury appears a key event in the atherogenesis. Endothelial cell activation and/or injury are the characteristic features of Behçet's disease (BD). In this study, we investigated morphologic evidence of subclinical atherosclerosis in the BD patients by using high-resolution B-mode US. Thirty-four patients with BD without arterial involvement (male/female 21/13; mean age 34.6+/-8.5 years) were individually matched to control subjects on the basis of age (within 2 years) and sex. Subjects with diabetes mellitus, hypertension, evidence of myocardial infarction or cerebrovascular disease, and patients on long-term steroids (i.e., >6 months) were excluded from the study. Mean IMT values of the right carotid arteries were 0.81+/-0.17 mm for patients with BD, and 0.54+/-0.13 mm for healthy controls (P<0.001). Mean IMT values of the left carotid arteries were 0.82+/-0.16 mm for patients with BD, and 0.55+/-0.12 mm for healthy controls (P<0.001). The overall prevalence of carotid atherosclerotic plaques was higher among the patients than the controls [prevalence of plaques were 17.6% (6/34) in BD patients and 0% in healthy controls, P<0.05]. In conclusion, our data indicate morphologic evidence of subclinical atherosclerosis in patients with BD.
authors.affiliation: Department of Rheumatology, Gazi University School of Medicine, Ankara, Turkey. makifozturk@yahoo.com
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Oztürk
authors.forename: Suna O
authors.initials: SO
authors.lastname: Oktar
authors.forename: Selman
authors.initials: S
authors.lastname: Unverdi
authors.forename: Kemal
authors.initials: K
authors.lastname: Ureten
authors.forename: Berna
authors.initials: B
authors.lastname: Göker
authors.forename: Seminur
authors.initials: S
authors.lastname: Haznedaroglu
authors.forename: Gülten
authors.initials: G
authors.lastname: Sungur
authors.forename: Kadriye A
authors.initials: KA
authors.lastname: Reis
authors.forename: A Mesut
authors.initials: AM
authors.lastname: Onat
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D001528:Behcet Syndrome / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography / Q000379:methods*