title: A new variant of the mouse Akp1 locus.
abstract: A new electrophoretic migration type of alkaline phosphatase 1 (Akp1) was found on the cellulose acetate electrophoresis for kidney and liver homogenates of KWHM mouse, a newly established inbred strain derived from the Korean wild mouse (Mus musculus molossinus). This new type of alkaline phosphatase 1 was distinguished from previously reported AKP1A and AKP1B types in the mouse, and tentatively named AKP1C. In genetic analysis by mating experiments between KWHM and C57BL/6J (AKP1A) or BALB/cA (AKP1B), the phenotypic segregation ratios of AKP1A : AKP1AC : AKP1C or AKP1B : AKP1BC : AKP1C were 1 : 2 : 1 in both groups of F2 generations. It was therefore concluded that AKP1C type is controlled by Akp1c allele which is codominant with Akp1a and Akp1b alleles.
authors.affiliation: ICLAS Monitoring Subcenter Korea, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, Korea.
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Young-Suk
authors.initials: YS
authors.lastname: Won
authors.forename: Yang-Kyu
authors.initials: YK
authors.lastname: Choi
authors.forename: Ki-Hoan
authors.initials: KH
authors.lastname: Nam
authors.forename: Hyoung-Chin
authors.initials: HC
authors.lastname: Kim
authors.forename: Byung-Hwa
authors.initials: BH
authors.lastname: Hyun
authors.forename: Jun-Gyo
authors.initials: JG
authors.lastname: Suh
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Oh
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics* / Q000378:metabolism; D000483:Alleles; D000818:Animals; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D014644:Genetic Variation; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice / Q000235:genetics*; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains
chemical_list: D000469:Alkaline Phosphatase