Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis.
Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2',3'-dihydroxy-4',6'-dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. Of these constituents, compounds 2 (IC50: 3.89 +/- 0.39 microM) and 3 (IC50: 9.77 +/- 0.26 microM) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 (IC50: 28.4 +/- 2.62 microM) exhibited moderate inhibitory activity.
Kiem
Phan Van
PV
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Caugiay, Hanoi.
Minh
Chau Van
CV
Huong
Hoang Thanh
HT
Lee
Jung Joon
JJ
Lee
Im Seon
IS
Kim
Young Ho
YH
D029061:Annonaceae; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001593:Benzyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D000432:Methanol / Q000737:chemistry; D050778:NFATC Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C507559:2',3'-dihydroxy-4',6'-dimethoxydihydrochalcone; C507556:2-methoxybenzyl benzoate; D001565:Benzoates; D001593:Benzyl Compounds; D047188:Chalcones; D044950:Flavanones; D047309:Flavones; D044948:Flavonols; D050778:NFATC Transcription Factors; D010636:Phenols; D010936:Plant Extracts; C507557:negletein; C099069:astilbin; C012526:quercitrin; D011794:Quercetin; C028610:flavanone; D000432:Methanol