title: Interstitial cystitis and infectious agents.
abstract: Interstitial cystitis (IC) is a syndrome consisting of severe refractory bladder symptoms of unknown etiology. The disease tends to affect Caucasian women with a mean age of 40 years, with 25% of patients under the age of 30. Few population based epidemiological studies of IC have been performed. We analyzed a case of interstitial cystitis in a 42-year-old non-smoker woman. In two biopsy samples the presence of viral DNA of human polyomavirus BK (BKV), human herpes virus type 1 and type 2 (HHV- 1 and HHV-2), adenovirus, human papillomavirus (HPV) and bacterial DNA (Chlamydia trachomatis and Mycoplasma genitalium) were evaluated by means of polymerase chain reaction (PCR). Both samples resulted positive only for BKV and HPV DNA. HPV genotyping revealed the presence of HPV-66 that is associated with a high risk of cancer development. Thus the finding of a viral co-infection could support the hypothesis of the multi-factorial origin of this pathology.
authors.affiliation: Department of Public Health Sciences, La Sapienza University, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Fioriti
authors.forename: M
authors.initials: M
authors.lastname: Penta
authors.forename: M
authors.initials: M
authors.lastname: Mischitelli
authors.forename: A M
authors.initials: AM
authors.lastname: Degener
authors.forename: A
authors.initials: A
authors.lastname: Pierangeli
authors.forename: V
authors.initials: V
authors.lastname: Gentile
authors.forename: R
authors.initials: R
authors.lastname: Nicosia
authors.forename: C
authors.initials: C
authors.lastname: Gallinelli
authors.forename: F
authors.initials: F
authors.lastname: Chiarini
authors.forename: V
authors.initials: V
authors.lastname: Pietropaolo
mesh_terms: D000256:Adenoviridae / Q000737:chemistry; D000328:Adult; D001739:BK Virus / Q000737:chemistry / Q000235:genetics; D002692:Chlamydia trachomatis / Q000737:chemistry / Q000235:genetics; D018856:Cystitis, Interstitial / Q000382:microbiology* / Q000821:virology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D005838:Genotype; D018259:Herpesvirus 1, Human / Q000737:chemistry / Q000235:genetics; D018258:Herpesvirus 2, Human / Q000737:chemistry / Q000235:genetics; D006801:Humans; D045704:Mycoplasma genitalium / Q000737:chemistry / Q000235:genetics; D027383:Papillomaviridae / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D004269:DNA, Bacterial; D004279:DNA, Viral