Antidiabetic effects of ajoene in genetically diabetic KK-A(y) mice.
Antidiabetic effects of ajoene, derived from garlic, were investigated in genetically diabetic KK-A(y) mice. Four-week-old male KK-A(y) mice were kept on a laboratory diet containing 0.02 or 0.05% of ajoene for 8 wk. The elevation of water intake was suppressed depending on ajoene intake. The levels of plasma glucose in the 0.05% ajoene-containing diet group was significantly suppressed to 73.8% compared with the control group at the 8th wk. Similarly, the plasma triglyceride level was significantly suppressed. It is suggested that hyperglycemia and hypertriglyceridemia are suppressed by ajoene treatment.
Hattori
Atsuhiko
A
Biodevelopment Division, Central Institute, Nagoya Seiraku Co. Ltd., 310 Nakasuna-cho, Tempaku-ku, Nagoya, Aichi 468-0065, Japan.
Yamada
Norihiko
N
Nishikawa
Tomoaki
T
Fukuda
Hiroyuki
H
Fujino
Tsuchiyoshi
T
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D004220:Disulfides / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D004326:Drinking / Q000187:drug effects; D005737:Garlic / Q000737:chemistry; D006943:Hyperglycemia / Q000188:drug therapy / Q000503:physiopathology; D015228:Hypertriglyceridemia / Q000188:drug therapy / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013454:Sulfoxides; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D004220:Disulfides; D007004:Hypoglycemic Agents; D013454:Sulfoxides; D014280:Triglycerides; C048980:ajoene