Identification of the target self-antigens in reperfusion injury.
Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
Zhang
Ming
M
CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.
Alicot
Elisabeth M
EM
Chiu
Isaac
I
Li
Jinan
J
Verna
Nicola
N
Vorup-Jensen
Thomas
T
Kessler
Benedikt
B
Shimaoka
Motomu
M
Chan
Rodney
R
Friend
Daniel
D
Mahmood
Umar
U
Weissleder
Ralph
R
Moore
Francis D
FD
Carroll
Michael C
MC
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity; D002199:Capillary Permeability; D006614:Hindlimb; D018398:Homeodomain Proteins / Q000235:genetics; D007113:Immunity, Innate; D007075:Immunoglobulin M / Q000276:immunology*; D007511:Ischemia; D007583:Jejunum / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000276:immunology / Q000473:pathology; D024507:Nonmuscle Myosin Type IIA / Q000276:immunology*; D015427:Reperfusion Injury / Q000276:immunology*
D001324:Autoantigens; D018398:Homeodomain Proteins; D007075:Immunoglobulin M; C064658:RAG-1 protein; D024507:Nonmuscle Myosin Type IIA