Gene regulation by histone H1: new links to DNA methylation.
Linker histones of the H1 family are among the most abundant components of chromatin. In this issue of Cell, the effect of H1 downregulation on gene expression is examined. Although a 50% reduction of histone H1 levels in embryonic stem cells affects chromatin structure globally, the expression of very few genes is altered. Intriguingly, this study reveals a new link between H1 and DNA methylation.
Rupp
Ralph A W
RA
Adolf-Butenandt-Institut, Molekularbiologie, Schillerstr. 44 . 80336 München, Germany.
Becker
Peter B
PB
D000818:Animals; D019175:DNA Methylation; D005786:Gene Expression Regulation / Q000502:physiology*; D006657:Histones / Q000502:physiology*; D006801:Humans
D006657:Histones