title: Hemodynamic effects of bupropion in anesthetized dogs.
abstract: Bupropion is a non-nicotinic drug used in smoking cessation therapy. However, its acute effects remain unclear. In this study, we investigated the effects of bupropion on hemodynamic parameters in pentobarbital-anesthetized mongrel dogs. Bupropion administered either in bolus injections (3 or 6 mg/kg, i.v.) or in cumulative doses of 0.01, 0.1, 1, 3 and 10 mg/kg showed, in both studies, a significant increase of mean pulmonary arterial pressure and pulmonary vascular resistance index. These results show that bupropion can elevate the pulmonary pressure. Further investigations should be done to test this effect in smokers with chronic obstructive pulmonary disease.
authors.affiliation: Cardiovascular Pharmacology and Hypertension Division, Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), SP, Brazil.
authors.forename: Maria Ondina
authors.initials: MO
authors.lastname: Paganelli
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Tanus-Santos
authors.forename: Maricene
authors.initials: M
authors.lastname: Sabha
authors.forename: Joaquim Francisco
authors.initials: JF
authors.lastname: do Prado
authors.forename: Marco Vinicíus
authors.initials: MV
authors.lastname: Chaud
authors.forename: Luís Cláudio
authors.initials: LC
authors.lastname: Martins
authors.forename: Heitor
authors.initials: H
authors.lastname: Moreno
mesh_terms: D000771:Anesthesia, Intravenous; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D016642:Bupropion / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D010424:Pentobarbital