Genetics of restless legs syndrome.
Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.
Mata
Ignacio F
IF
Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Bodkin
Cynthia L
CL
Adler
Charles H
CH
Lin
Siong-Chi
SC
Uitti
Ryan J
RJ
Farrer
Matthew J
MJ
Wszolek
Zbigniew K
ZK
D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D012148:Restless Legs Syndrome / Q000453:epidemiology / Q000235:genetics*