title: Feline ocular chlamydiosis: clinical and microbiological effects of topical and systemic therapy.
abstract: Conjunctival swabs taken from a two-month-old kitten showing ocular discharge were found to be positive for Chlamydophila felis by PCR and isolation. The cat was treated with topical 1% tetracycline ophthalmic ointment twice a day for 60 days. At the end of the treatment, the cat showed no ocular signs and conjunctival swabs resulted PCR and isolation negative for C. felis. Forty days later, the ocular discharge recurred and C. felis was isolated from conjunctival swabs taken from both the cat's eyes. Twenty days of doxycycline systemic treatment at 10 mg/kg once daily was started. The treatment resulted in a complete clinical recovery after a few days. C. felis was not isolated or amplified on the 10th day after beginning the treatment. The cat's conjunctival swabs were also PCR and isolation negative on the 10th, 30th, 60th, 90th, 120th and 240th days after the end of therapy.
authors.affiliation: Department of Veterinary Public Health and Animal Pathology, University of Bologna, Ozzano Emilia Bologna, Bologna, Italy. manuela.donati@unibo.it
authors.forename: Manuela
authors.initials: M
authors.lastname: Donati
authors.forename: Silvia
authors.initials: S
authors.lastname: Piva
authors.forename: Antonietta
authors.initials: A
authors.lastname: Di Francesco
authors.forename: Costanza
authors.initials: C
authors.lastname: Mazzeo
authors.forename: Marco
authors.initials: M
authors.lastname: Pietra
authors.forename: Roberto
authors.initials: R
authors.lastname: Cevenini
authors.forename: Raffaella
authors.initials: R
authors.lastname: Baldelli
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D002415:Cats; D023501:Chlamydophila / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D023521:Chlamydophila Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D003228:Conjunctiva / Q000382:microbiology; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D005122:Exudates and Transudates / Q000382:microbiology; D008297:Male; D016133:Polymerase Chain Reaction; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D013752:Tetracycline; D004318:Doxycycline