Vascular endothelial growth factor receptor blockade by SU5416 combined with pulsatile shear stress causes apoptosis and subsequent proliferation of apoptosis-resistant endothelial cells.
Sakao
Seiichiro
S
Pulmonary Hypertension Center, Denver, CO, USA. seiichiro.sakao@uchsc.edu
Taraseviciene-Stewart
Laimute
L
Lee
Jong Deog
JD
Wood
Kathy
K
Cool
Carlyne D
CD
Voelkel
Norbert F
NF
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D017209:Apoptosis / Q000502:physiology*; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000166:cytology; D011758:Pyrroles / Q000494:pharmacology*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors*; D013314:Stress, Mechanical
D020533:Angiogenesis Inhibitors; D007211:Indoles; D011758:Pyrroles; C116890:Semaxinib; D040262:Receptors, Vascular Endothelial Growth Factor