title: Proton transfers in the bacteriorhodopsin photocycle.
abstract: The steps in the mechanism of proton transport in bacteriorhodopsin include examples for most kinds of proton transfer reactions that might occur in a transmembrane pump: proton transfer via a bridging water molecule, coupled protonation/deprotonation of two buried groups separated by a considerable distance, long-range proton migration over a hydrogen-bonded aqueous chain, and capture as well as release of protons at the membrane-water interface. The conceptual and technical advantages of this system have allowed close examination of many of these model reactions, some at an atomic level.
authors.affiliation: Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA. jlanyi@orion.oac.uci.edu
authors.forename: Janos K
authors.initials: JK
authors.lastname: Lanyi
mesh_terms: D001436:Bacteriorhodopsins / Q000737:chemistry* / Q000378:metabolism*; D001692:Biological Transport; D006860:Hydrogen Bonding; D007700:Kinetics; D008027:Light; D008954:Models, Biological; D011522:Protons
chemical_list: D011522:Protons; D001436:Bacteriorhodopsins