[The changes of some vasoactive substances after operation in patients with obstructive sleep apnea-hypopnea syndrome].
OBJECTIVE
To observe the changes of thromboxane B2 (TXB2), rennin, angiotensin II (AT-II), endothelin 1 (ET-1) and anticardiolipin antibody (ACA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the operation.


METHODS
Fifty-four cases of OSAHS confirmed by polysomnography (PSG) were selected as the OSAHS group and 20 normal donors without OSAHS were selected as the control group. Plasma levels of TXB2, rennin, AT- II, ET-1 and ACA were detected by enzyme-linked immunosorbent assay (ELISA).


RESULTS
Plasma levels of TXB2, rennin, AT-II, ET-1 and ACA were higher in patients with OSAHS than those in control group (P < 0.05 or P < 0.01), and the operation therapy decreased them significantly (P < 0.05 or P <0.01). All the plasma parameters were correlated positively with AHI, and negatively with SaO2.


CONCLUSIONS
The results indicate the patients with OSAHS were susceptible to thromboembolism disease. Operation therapy is effective in correcting TXB2, rennin, AT-II, ET-1 and ACA.
Yao
Xingqi
X
Department of Otolaryngology, Wuhan General Hospital of PLA, Wuhan, 430070, China. yaohq64@sohu.com
Sun
Yi
Y
Chu
Yong
Y
Luo
Yanyun
Y
Zhang
Guifeng
G
Wang
Lun
L
D000804:Angiotensin II / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016022:Case-Control Studies; D012085:Chymosin / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D006801:Humans; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery*; D013929:Thromboxane B2 / Q000097:blood
D017152:Antibodies, Antiphospholipid; D019332:Endothelin-1; D000804:Angiotensin II; D013929:Thromboxane B2; D012085:Chymosin