title: Acetogenins in Annona muricata L. (annonaceae) leaves are potent molluscicides.
abstract: An ethanolic extract of the leaves of Annona muricata was shown to be toxic to adult forms of the snail Biomphalaria glabrata (LC50 9.32 microg mL(-1)) and to larvae of the brine shrimp Artemia salina (LC50 0.49 microg mL(-1)). Activity-guided fractionation of the extract gave rise to a sample with high molluscicidal activity that contained the acetogenins, annonacin (90%), isoannonacin (6%) and goniothalamicin (4%).
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, 50.740-901 Recife-PE, Brazil.
authors.forename: J De S
authors.initials: Jde S
authors.lastname: Luna
authors.forename: J M
authors.initials: JM
authors.lastname: De Carvalho
authors.forename: M R F
authors.initials: MR
authors.lastname: De Lima
authors.forename: L W
authors.initials: LW
authors.lastname: Bieber
authors.forename: Edson De S
authors.initials: Ede S
authors.lastname: Bento
authors.forename: X
authors.initials: X
authors.lastname: Franck
authors.forename: A E G
authors.initials: AE
authors.lastname: Sant'ana
mesh_terms: D054378:Acetogenins; D000818:Animals; D031041:Annona / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008974:Mollusca / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D054378:Acetogenins; D005233:Fatty Alcohols; D007783:Lactones