Multi-drug transporter MDR1 gene polymorphism and prognosis in adult acute lymphoblastic leukemia.
P-glycoprotein (P-gp), a membrane transporter encoded by MDR1 gene, influences pharmacokinetics of anti-cancer drugs and contributes to multi-drug resistance phenotype in adult acute lymphoblastic leukemia (ALL). In this study, we explored prognostic and functional role of single nucleotide polymorphism C3435T in MDR1 gene in 44 adult Caucasian patients with ALL. We found that the outcome of chemotherapy as well as MDR1 gene expression, P-gp expression and P-gp activity in isolated ALL blast cells were comparable among the patients carrying different MDR1 genotypes. Our results suggest that C3435T polymorphism in MDR1 gene is not a major prognosticator in adult ALL.
Jamroziak
Krzysztof
K
Department of Haematology, Medical University of Łódź, Ciołkowskiego 2, PL 93-510 Łódź, Poland.
Balcerczak
Ewa
E
Cebula
Barbara
B
Kowalczyk
Monika
M
Panczyk
Mariusz
M
Janus
Agnieszka
A
Smolewski
Piotr
P
Mirowski
Marek
M
Robak
Tadeusz
T
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001854:Bone Marrow Cells / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy* / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D016019:Survival Analysis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D012333:RNA, Messenger