title: Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids.
abstract: Keeping in view the interesting chemistry and pharmacological importance of harmine series of bases -- the beta-carboline alkaloids, a number of new derivatives of tetrahydroharmine and harmalol have been prepared and characterized through spectral studies. Some of these derivatives showed spasmolytic activity. It was observed that all the N-acyl tetrahydroharmine derivatives are stable, not labile and no ring opening occurs in these compounds, as reported recently.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. sabira@khi.comsats.net.pk
authors.forename: Sabira
authors.initials: S
authors.lastname: Begum
authors.forename: Syed
authors.initials: S
authors.lastname: Imran Hassan
authors.forename: Bina S
authors.initials: BS
authors.lastname: Siddiqui
authors.forename: Rehana
authors.initials: R
authors.lastname: Ifzal
authors.forename: Sobiya
authors.initials: S
authors.lastname: Perwaiz
authors.forename: Tahira
authors.initials: T
authors.lastname: Kiran
authors.forename: Farhana
authors.initials: F
authors.lastname: Shaheen
authors.forename: M Nabeel
authors.initials: MN
authors.lastname: Ghayur
authors.forename: Anwar H
authors.initials: AH
authors.lastname: Gilani
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D006247:Harmine / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D010276:Parasympatholytics / Q000494:pharmacology*; D011817:Rabbits; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000470:Alkaloids; D010276:Parasympatholytics; D006247:Harmine