title: Serum interleukin 8 levels correlate with synovial fluid levels in patients with aseptic loosening of hip prosthesis.
abstract: Levels of inflammatory cytokines (tumor necrosis factor alpha, interleukin [IL] 6, and IL-8) in serum from patients with osteolysis on radiographs after hip arthroplasty [osteolysis(+), n = 28], patients without osteolysis after hip arthroplasty [osteolysis(-), n = 24], and nonoperated healthy subjects [controls, n = 20] were determined. In addition, cytokine levels in synovial fluid from patients undergoing revision total hip arthroplasty (n = 14) for loosening were measured and compared with each other and with the area of osteolysis on radiographs. Serum IL-6 and IL-8 levels were significantly higher in the osteolysis(+) group than in the osteolysis(-) or the control groups. Furthermore, a significant correlation was found between the serum and synovial fluid IL-8 levels and between synovial fluid IL-8 levels and the area of osteolysis in patients undergoing revision total hip arthroplasty. Therefore, serum IL-8 levels could be a useful periprosthetic osteolysis marker.
authors.affiliation: Department of Orthopaedic Surgery, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Tanaka
authors.forename: Yugi
authors.initials: Y
authors.lastname: Yasunaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Hisatome
authors.forename: Takuma
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwamori
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
mesh_terms: D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D016209:Interleukin-8 / Q000032:analysis* / Q000097:blood*; D008297:Male; D010014:Osteolysis / Q000378:metabolism*; D011475:Prosthesis Failure; D018709:Statistics, Nonparametric; D013582:Synovial Fluid / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha