title: The burden of rotavirus diarrhea in Khanh Hoa Province, Vietnam: baseline assessment for a rotavirus vaccine trial.
abstract: BACKGROUND
  In Vietnam, rotavirus is seen as a priority disease because studies have demonstrated that >50% of children hospitalized for treatment of diarrhea have rotavirus as the pathogen. To anticipate the availability of new vaccines, we have examined our field area in Nha Trang, Khanh Hoa Province, Vietnam, as a potential site to conduct a field trial of a future rotavirus vaccine.
  
  
  METHODS
  Data from a population census, incidence rates of diarrhea from a previous cholera vaccine trial and hospitalization rates from computerized records collected from the 2 main hospitals in the province were reviewed to estimate the burden of rotavirus-related diarrhea that might be expected during a field trial of a rotavirus vaccine.
  
  
  RESULTS
  For a birth cohort of approximately 5000 children, we would expect approximately 2500 clinic visits and 650-850 hospitalizations for treatment of diarrhea, of which approximately 375-425 would be attributable to rotavirus. For the Vietnamese birth cohort of 1,639,000 children, these numbers translate into approximately 820,000 clinic visits, 122,000-140,000 hospitalizations and 2900-5400 deaths annually attributable to rotavirus-related diarrhea.
  
  
  CONCLUSIONS
  Vietnam is an early adaptor of new vaccines, has high national coverage rates (>85%) for childhood immunization and receives international donor support for the introduction of new vaccines. We found the epidemiologic features of rotavirus in rural Vietnam to be more similar to those of rotavirus in a developed country than to those of rotavirus in India or Bangladesh.
authors.affiliation: National Institute for Hygiene and Epidemiology, Hanoi, Vietnam.
authors.forename: Dang Duc
authors.initials: DD
authors.lastname: Anh
authors.forename: Vu Dinh
authors.initials: VD
authors.lastname: Thiem
authors.forename: Thea K
authors.initials: TK
authors.lastname: Fischer
authors.forename: Do Gia
authors.initials: DG
authors.lastname: Canh
authors.forename: Truong Tan
authors.initials: TT
authors.lastname: Minh
authors.forename: Le Huu
authors.initials: le H
authors.lastname: Tho
authors.forename: Nguyen
authors.initials: N
authors.lastname: Van Man
authors.forename: Le Thi
authors.initials: le T
authors.lastname: Luan
authors.forename: Paul
authors.initials: P
authors.lastname: Kilgore
authors.forename: Lorenz
authors.initials: L
authors.lastname: von Seidlein
authors.forename: Roger I
authors.initials: RI
authors.lastname: Glass
mesh_terms: D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000401:mortality / Q000821:virology*; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000401:mortality; D014744:Vietnam / Q000453:epidemiology