[Study on the pretreatment of the series of HPD macroporous adsorption resin].
OBJECTIVE
To develop a method for the pretreatment of the series of HPD macroporous adsorption resin (MAR).


METHODS
The effect of 2% NaOH to pretreatment of the series of HPD MAR was studied by gas chromatography and UV spectrometery.


RESULTS
The eluting effect by ethanol was better after the MAR was marinated and eluted by 2% NaOH.


CONCLUSIONS
The pretreatment of the series of HPD MAR was: after marinated and eluted by 2% NaOH, the series of HPD MAR were eluted by ethanol at 2 BV x h(-1) at 60 degrees C for 3-4 bed volumes (BV). At then the UV absorbance of eluate was 0.2-0.5. Benzene was not detected and the other residues less than 10 mg x L(-1) in eluted-MAR by GC. And the MARs match to the standard of medicine.
Jia
Cun-Qin
CQ
School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.
Li
Yang-Chun
YC
Tu
Peng-Fei
PF
Zhang
Hong-Quan
HQ
D000327:Adsorption; D002849:Chromatography, Gas; D004340:Drug Contamination; D000431:Ethanol; D009281:Naphthalenes / Q000032:analysis; D012117:Resins, Synthetic / Q000737:chemistry; D012972:Sodium Hydroxide; D013056:Spectrophotometry, Ultraviolet; D014050:Toluene / Q000032:analysis
D009281:Naphthalenes; D012117:Resins, Synthetic; C031721:naphthalene; D014050:Toluene; D000431:Ethanol; D012972:Sodium Hydroxide