title: Effects of intravenous diazepam or microdose medetomidine on propofol-induced sedation in dogs.
abstract: This crossover study tested the hypothesis that both diazepam and microdose medetomidine would comparably reduce the amount of propofol required to induce sedation. Four different medications, namely high-dose diazepam (0.4 mg/kg intravenously [IV]), low-dose diazepam (0.2 mg/kg IV), medetomidine (1 mug/kg IV), and placebo (0.5 mL physiological saline IV) were followed by propofol (8 mg/kg IV) titrated to a point where intubation could be performed. The effects of medetomidine were comparable to the effects of high-dose diazepam and significantly better than the effects of low-dose diazepam or placebo. Dogs in all treatment groups had transient hypoxemia, and induction and recovery qualities were similar.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Arts and Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
authors.forename: Jeff C H
authors.initials: JC
authors.lastname: Ko
authors.forename: Mark E
authors.initials: ME
authors.lastname: Payton
authors.forename: Alison G
authors.initials: AG
authors.lastname: White
authors.forename: David S
authors.initials: DS
authors.lastname: Galloway
authors.forename: Tomohito
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000771:Anesthesia, Intravenous / Q000379:methods / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D018592:Cross-Over Studies; D003975:Diazepam / Q000008:administration & dosage*; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D020926:Medetomidine / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D015742:Propofol; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide; D020926:Medetomidine; D003975:Diazepam; D010100:Oxygen; D015742:Propofol