Antimicrobial activity of some hydroxamic acids.
Several hydroxamic acids, viz., N-benzyl-N'-hydroxysuccinamide (BHS), poly[alpha,beta-(N-hydroxy)-DL-aspartamide] (PHA), poly[alpha,beta-(N-hydroxy-N-methyl-DL-aspartamide)] (PMHA) and poly[alpha,beta-(N-hydroxy)-DL- aspartamide]/poly[alpha,beta-(N-2-hydroxyethyl)-DL-aspartamide] (PHA-PHEA 1:1) were prepared and screened for their antimicrobial activity. Ten Gram-positive and 7 Gram-negative species of bacteria, 5 Candida species, 4 dermatophyte species and 3 mould species were used in tests. Compound showed no antimicrobial activity on any of the tested microorganisms. Other compounds showed a narrow spectrum of antibacterial activity, but no antifungal activity.
Pepeljnjak
Stjepan
S
Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. spep33@yahoo.com
Zorc
Branka
B
Butula
Ivan
I
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis; D015169:Colony Count, Microbial; D004202:Disinfectants / Q000138:chemical synthesis / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006462:Hemolytic Plaque Technique; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D004202:Disinfectants; D006877:Hydroxamic Acids; D001224:Aspartic Acid