Anesthetic management of autoimmune polyglandular syndrome (Schmidt's syndrome)--a case report-.
BACKGROUND
Autoimmune polyglandular syndromes (APS) are complex diseases with diverse clinical presentations resulting from involvement of multiple endocrine glands. Surgery under anesthetic in these patients is challenging. A case of Schmidt syndrome (autoimmune polyglandular syndrome type 11) that developed adrenocortical insufficiency in the postoperative period is reported. Etiology, pathogenesis, types and anesthetic problems associated with these cases are discussed.


METHODS
A 41 yr old female patient, diagnosed to have APS (Schmidt syndrome) presented for uterine surgery. She had autoimmune glandular involvement of pituitary, thyroid, parathyroid, adrenals and melanocytes and was on hormone replacements for the deficiencies incurred, which were continued till the morning of surgery. Surgery was conducted under general anesthetic combined with epidural analgesia. In spite of supplementation of steroid in physiological doses prior to surgery, she developed hemodynamic instability in the early postoperative period, but could be successfully resuscitated with additional steroid dosage and fluids.


CONCLUSIONS
This patient presented with multiglandular endocrine involvement necessitating timely, adequate hormone replacement and appropriate fluid management. These challenges require careful approach to anesthetic management.
Kuriakose
Renju
R
Regional Center, Trivandrum, Kerala, India. renjurcc@yahoo.co.in
Koshy
Rachel C
RC
D000328:Adult; D000768:Anesthesia, General; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000601:surgery*; D018231:Leiomyomatosis / Q000150:complications / Q000601:surgery*; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications / Q000503:physiopathology