title: Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling.
abstract: A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTc-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.
authors.affiliation: Laboratoire de Chimie Inorganique, EA 807, Université Paul Sabatier, Bat. IIR1, 118, route de Narbonne, 31062 Toulouse, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Le Gal
authors.forename: Sandra
authors.initials: S
authors.lastname: Michaud
authors.forename: Marie
authors.initials: M
authors.lastname: Gressier
authors.forename: Yvon
authors.initials: Y
authors.lastname: Coulais
authors.forename: Eric
authors.initials: E
authors.lastname: Benoist
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D008024:Ligands; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000737:chemistry; D013667:Technetium / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D008024:Ligands; D012211:Rhenium; D013667:Technetium