Discorhabdin W, the first dimeric discorhabdin.
Discorhabdin W (1), isolated from a New Zealand Latrunculia sp. sponge, is a symmetrical dimer with potent in vitro activity against the P388 murine leukemia cell line. The structure and stereochemistry were assigned by using 1D- and 2D-NMR experiments and mass spectrometry. Discorhabdins B (2), D (3), G/I (4), and L (5) were also isolated from the same sponge.
Lang
Gerhard
G
Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Pinkert
André
A
Blunt
John W
JW
Munro
Murray H G
MH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013841:Thiazepines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011809:Quinones; D013141:Spiro Compounds; D013841:Thiazepines; C507038:discorhabdin W