title: Antianxiety effects of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice.
abstract: This work presents the behavioral effects of riparin I (methyl ether of N-benzoyl tyramine) from unripe fruit of Aniba riparia (Lauraceae) on the elevated plus maze, open field, rota rod and hole board tests in mice. Riparin I was administered acutely by intraperitoneal (i.p.) and oral routes to male mice at doses of 25 and 50 mg/kg. The results showed that riparin I (25 and 50 mg/kg, i.p. and per os) increased the number of entries and the time of permanence in the open arms in the plus maze test. Similarly, in the hole board test, riparin I in both routes increased the number of head dips. Riparin I with both doses and routes had no effects on spontaneous motor activity in mice or in the rota rod test, but decreased the number of groomings. These results showed that riparin I by both administration routes has effects on the central nervous system with antianxiety effects on the plus maze and hole board tests. The substance is devoid of myorelaxant effects.
authors.affiliation: Department of Physiology and Pharmacology, Federal University of Ceará, Brazil. clea@ufc.br
authors.forename: Francisca Cléa Florenço
authors.initials: FC
authors.lastname: de Sousa
authors.forename: Andreisa Paiva
authors.initials: AP
authors.lastname: Monteiro
authors.forename: Carla Thiciane Vasconcelos
authors.initials: CT
authors.lastname: de Melo
authors.forename: Glício Rebouças
authors.initials: GR
authors.lastname: de Oliveira
authors.forename: Silvânia Maria Mendes
authors.initials: SM
authors.lastname: Vasconcelos
authors.forename: Marta Maria
authors.initials: MM
authors.lastname: de França Fonteles
authors.forename: Stanley Juan Chavez
authors.initials: SJ
authors.lastname: Gutierrez
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.forename: Glauce Socorro Barros
authors.initials: GS
authors.lastname: Viana
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D005638:Fruit; D019770:Lauraceae; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D001549:Benzamides; D010936:Plant Extracts; C087987:riparin III; D003975:Diazepam; D014439:Tyramine