G-protein-coupled receptors: past, present and future.
The G-protein-coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have therapeutic actions across a wide range of human diseases ranging from allergic rhinitis to pain, hypertension and schizophrenia. This review provides a brief historical overview of the properties and signalling characteristics of this important family of receptors.
Hill
Stephen J
SJ
Institute of Cell Signalling, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH. stephen.hill@nottingham.ac.uk
D000818:Animals; D001665:Binding Sites; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008024:Ligands; D011869:Radioligand Assay; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000266:history* / Q000502:physiology; D015398:Signal Transduction
D008024:Ligands; D043562:Receptors, G-Protein-Coupled