title: Delicate percutaneous renal artery stenting minimizes postoperative renal injury and protects kidney in patients with severe atherosclerotic renal artery stenosis and impaired renal function.
abstract: Percutaneous transluminal renal artery stenting (PTRAS) is associated with declining renal function in a non-negligible portion of patients and is inflicted by different mechanisms, including atheroembolism. This study investigated whether delicate PTRAS to reduce atheroembolism might minimize postoperative renal injury and better preserve renal function. Patients undergoing PTRAS performed by experienced interventional cardiologists, applying coronary intervention concepts, techniques, devices and delicacy principles whenever possible, were prospectively studied. A total of 34 patients (29 M/5 F) with impaired renal function (group A, creatinine 2.4 +/- 0.1 mg/dL) and another 20 patients (16 M/4 F) with normal serum creatinine (group B, baseline creatinine 1.2 +/- 0.0 mg/dL) were studied. PTRAS was successfully performed in all but one group A patient. During a 6-month follow-up, systolic and diastolic blood pressure (130 +/- 2 versus 148 +/- 4 mmHg, P = 0.001 and 70 +/- 2 versus 78 +/- 3 mmHg, P = 0.006) and serum creatinine (2.1 +/- 0.1 versus 2.4 +/- 0.1 mg/dL, P < 0.001) were all significantly lowered in group A patients. Using a 20% change cut-off value, renal function improved in eight (24%), remained unchanged in 24 patients (73%), and deteriorated in only one patient (3%). The corresponding alterations in blood pressure and renal function were insignificant in group B patients. Patients with bilateral involvement (eleven patients) also had significantly lowered serum creatinine on follow-up. In conclusion, delicately practiced PTRAS can reduce the rate of postprocedural renal deterioration in patients with impaired renal function, and should be adopted in every renal intervention.
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Chen-Rong
authors.initials: CR
authors.lastname: Tsao
authors.forename: Wen-Lieng
authors.initials: WL
authors.lastname: Lee
authors.forename: Tsun-Jui
authors.initials: TJ
authors.lastname: Liu
authors.forename: Ying-Tsung
authors.initials: YT
authors.lastname: Chen
authors.forename: Chih-Tai
authors.initials: CT
authors.lastname: Ting
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods; D001161:Arteriosclerosis / Q000503:physiopathology / Q000628:therapy*; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D012077:Renal Artery / Q000473:pathology; D012078:Renal Artery Obstruction / Q000503:physiopathology / Q000628:therapy*; D015607:Stents
chemical_list: D003404:Creatinine