title: Anti-inflammatory, analgesic and diuretic activity of Polygonum lanatum Roxb.
abstract: The hexane (PLH), ethyl acetate (PLE) and methanol (PLM) extracts of dried whole plant parts of Polygonum lanatum Roxb. (Family, Polygonaceae) obtained by successive cold extraction, were subjected to evaluate anti-inflammatory, analgesic and diuretic activity in experimental animals. Oral administration of either PLH and PLM at a dose of 300 mg/kg body weight showed statistically significant (p < 0.001) inhibition of rat paw edema by 41.09% and 30.15%, respectively, which was comparable to that of standard drug phenylbutazone (42.15%). Compared to the inhibition of acetic acid-induced writhing by aminopyrine (69.94%, p < 0.001), treatment with either PLH, PLE or PLM elicited significant inhibition of acetic acid-induced writhing reflex by 44.80% (p < 0.001), 33.87% (p < 0.01) and 62.29% (p < 0.001), respectively. In addition, mild to potent diuretic activity was observed after oral administration of these extracts in Swiss albino mice.
authors.affiliation: Faculty of Pharmacy University of Dhaka, Dhaka 1000, Bangladesh.
authors.forename: Achinto
authors.initials: A
authors.lastname: Saha
authors.forename: Kawshik Kumar
authors.initials: KK
authors.lastname: Chowdhury
authors.forename: Sitesh Chandra
authors.initials: SC
authors.lastname: Bachar
authors.forename: Suvash Chandra
authors.initials: SC
authors.lastname: Roy
authors.forename: Joydeb Kumar
authors.initials: JK
authors.lastname: Kundu
mesh_terms: D000085:Acetates; D019342:Acetic Acid; D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001522:Behavior, Animal / Q000187:drug effects; D004232:Diuretics; D005260:Female; D006586:Hexanes; D007194:India; D008297:Male; D000432:Methanol; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D028502:Polygonum / Q000737:chemistry*; D051381:Rats; D020318:Rats, Long-Evans; D012997:Solvents
chemical_list: D000085:Acetates; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics; D006586:Hexanes; D010936:Plant Extracts; D012997:Solvents; C007650:ethyl acetate; D019342:Acetic Acid; D000432:Methanol