title: Pore size distributions of biodegradable polymer microparticles in aqueous environments measured by NMR cryoporometry.
abstract: NMR cryoporometry is a unique method permitting the investigation of pores in the microporous and mesoporous regimes for samples in aqueous environments. Here, we apply the technique to porous biodegradable polymer microparticles designed as devices for drug delivery in depot formulations. The results indicate that structural features too small to be captured in surface and fracture images obtained by SEM are able to be accessed using the technique, and that the evolution of pore structure can be studied for several days as the particles swell and degrade in the aqueous environment.
authors.affiliation: Division of Physical Chemistry and Industrial NMR Centre, Institute of Chemistry, School of Chemical Science and Engineering, Royal Institute of Technology, Teknikringen 30, SE-10044 Stockholm, Sweden.
authors.forename: Oleg
authors.initials: O
authors.lastname: Petrov
authors.forename: István
authors.initials: I
authors.lastname: Furó
authors.forename: Michael
authors.initials: M
authors.lastname: Schuleit
authors.forename: Rainer
authors.initials: R
authors.lastname: Domanig
authors.forename: Mark
authors.initials: M
authors.lastname: Plunkett
authors.forename: John
authors.initials: J
authors.lastname: Daicic
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers; D019344:Lactic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid