Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: a morphological study.
Crataegus (hawthorn) has long been used as a folk medicine all around the world. Most of the studies with Crataegus species focus on effects on heart failure and cardiovascular disease. The pharmacological effects of Crataegus have been attributed mainly to the content of flavonoids, procyanidin, aromatic acid and cardiotonic amines. The present study investigated the blood pressure and the structure of the coronary arterial wall of L-NAME-induced hypertensive rats given an aqueous leaf extract of C. tanacetifolia (100 mg/kg), for 4 weeks via gavage. It was observed that C. tanacetifolia, especially the hyperoside fraction, prevented L-NAME-induced hypertension in rats and had beneficial effects on the cardiovascular system.
Koçyildiz
Z Celebi
ZC
Istanbul University, Faculty of Medicine, Department of Physiology, Capa, Istanbul, Turkey.
Birman
H
H
Olgaç
V
V
Akgün-Dar
K
K
Melikoğlu
G
G
Meriçli
A H
AH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003331:Coronary Vessels / Q000166:cytology / Q000187:drug effects*; D027825:Crataegus / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000633:toxicity; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D007668:Kidney / Q000201:enzymology; D008055:Lipids / Q000097:blood; D008297:Male; D009206:Myocardium / Q000166:cytology; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D019331:NG-Nitroarginine Methyl Ester / Q000633:toxicity; D019001:Nitric Oxide Synthase / Q000032:analysis / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats
D004791:Enzyme Inhibitors; D008055:Lipids; D010936:Plant Extracts; C007145:crataegus extract; C021304:hyperoside; D011794:Quercetin; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester