title: The Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context.
abstract: MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-protein interaction database (MPPI) and a database of mammalian protein complexes is interconnected with MfunGD. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme which is widely used for the analysis of protein networks. The dataset is also supplemented with information about the literature that was used in the annotation process as well as links to the SIMAP Fasta database, the Pedant protein analysis system and cross-references to external resources. Proteins that so far were not manually inspected are annotated automatically by a graphical probabilistic model and/or superparamagnetic clustering. The database is continuously expanding to include the rapidly growing amount of functional information about gene products from mouse. MfunGD is implemented in GenRE, a J2EE-based component-oriented multi-tier architecture following the separation of concern principle.
authors.affiliation: Institute for Bioinformatics (MIPS), GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany. andreas.ruepp@gsf.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Ruepp
authors.forename: Octave Noubibou
authors.initials: ON
authors.lastname: Doudieu
authors.forename: Jos
authors.initials: J
authors.lastname: van den Oever
authors.forename: Barbara
authors.initials: B
authors.lastname: Brauner
authors.forename: Irmtraud
authors.initials: I
authors.lastname: Dunger-Kaltenbach
authors.forename: Gisela
authors.initials: G
authors.lastname: Fobo
authors.forename: Goar
authors.initials: G
authors.lastname: Frishman
authors.forename: Corinna
authors.initials: C
authors.lastname: Montrone
authors.forename: Christine
authors.initials: C
authors.lastname: Skornia
authors.forename: Steffi
authors.initials: S
authors.lastname: Wanka
authors.forename: Thomas
authors.initials: T
authors.lastname: Rattei
authors.forename: Philipp
authors.initials: P
authors.lastname: Pagel
authors.forename: Louise
authors.initials: L
authors.lastname: Riley
authors.forename: Dmitrij
authors.initials: D
authors.lastname: Frishman
authors.forename: Dimitrij
authors.initials: D
authors.lastname: Surmeli
authors.forename: Igor V
authors.initials: IV
authors.lastname: Tetko
authors.forename: Matthias
authors.initials: M
authors.lastname: Oesterheld
authors.forename: Volker
authors.initials: V
authors.lastname: Stümpflen
authors.forename: H Werner
authors.initials: HW
authors.lastname: Mewes
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D023281:Genomics; D020407:Internet; D051379:Mice / Q000235:genetics*; D046912:Multiprotein Complexes / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D040901:Proteomics; D012984:Software; D014584:User-Computer Interface
chemical_list: D046912:Multiprotein Complexes