title: Antimicrobial activity of flavonoids from Pelargonium radula (Cav.) L'Hérit.
abstract: Flavonoids from Pelargonium radula (Cav.) L'Hérit were purified by column chromatography. Two fractions were obtained: F1 (main flavonoid isoquercitrin) and F2 (main flavonoid rutin). In vitro antimicrobial activity of F1 and F2 were tested against eleven species of bacteria and eleven species of fungi. Both fractions demonstrated strong inhibitory activity against Staphylococcus aureus, Proteus rettgeri, Candida tropicalis and Microsporum gypseum. Staphylococcus sp. (coagulase-negative) and Candida lusitaniae were strongly inhibited only by fraction F1 and Fusarium graminearum only by fraction F2.
authors.affiliation: Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. spep33@yahoo.com
authors.forename: Stjepan
authors.initials: S
authors.lastname: Pepeljnjak
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Kalodera
authors.forename: Marijana
authors.initials: M
authors.lastname: Zovko
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D041022:Candida tropicalis / Q000187:drug effects / Q000254:growth & development; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects / Q000254:growth & development; D031316:Pelargonium / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D011511:Proteus / Q000187:drug effects / Q000254:growth & development; D011794:Quercetin / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D012431:Rutin / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D005419:Flavonoids; C016527:isoquercitrin; D012431:Rutin; D011794:Quercetin