[Thyroid transcription factors involved in the thyroid hormones biosynthesis].
The thyroid hormone biosynthesis is dependent on the level of the expression and the correct action of the basic proteins involved in this process: TSH receptor (TSH-R), sodium-iodine symporter (NIS), thyroglobulin (Tg), thyroid peroxidase (TPO) and iodothyronine deodinases type 1 (D1) and type 2 (D2). Transcription of the genes coding these proteins is regulated by TSH via cAMP cascade. Despite the thyroid-specific transcription factors are necessary for the transcription regulation of TSH-R, NIS, TG, TPO, DIO1 and DIO2 genes. Three thyroid transcription factors Titf1/Nkx2-1, Foxel and Pax8 seem to be essential for thyroid development, growth and function. Disturbances of the expression of these transcription factors and their co-operation could be responsible for the congenital thyroid gland disorders as well as in thyroid cancerogenesis.
Ambroziak
Michał
M
Zakład Biochemii Klinicznej, Centrum Medyczne Kształcenia Podyplomowego, Warszawa. ambroz@amwaw.edu.pl
Nauman
Alicja
A
D000818:Animals; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D013959:Thyroid Diseases / Q000235:genetics / Q000503:physiopathology; D013961:Thyroid Gland / Q000254:growth & development; D013963:Thyroid Hormones / Q000096:biosynthesis*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism*
C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D013963:Thyroid Hormones; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors