title: Composite lymphocyte-rich Hodgkin lymphoma and peripheral T-cell lymphoma associated with Epstein-Barr virus: a case report and review of the literature.
abstract: We report a case of a 65-year-old black man with combined Hodgkin lymphoma and T-cell lymphoma. The patient presented with diffuse lymphadenopathy, fever, weight loss, and night sweats. Subsequent biopsy of an axillary lymph node revealed a composite lymphoma composed of classic Hodgkin lymphoma and a peripheral T-cell lymphoma. A needle biopsy of the liver also showed involvement by the composite lymphoma. In situ hybridization studies revealed positive Epstein-Barr virus in Reed-Sternberg cells. Development of T-cell lymphoma following chemotherapy for Hodgkin lymphoma has been reported, but synchronous composite occurrence of both lesions is very rare. Furthermore, this is the first report of such occurrence in a black patient. We present a review of the literature and a discussion of the potential pathophysiologic role of Epstein-Barr virus in the early stages of T-cell lymphomagenesis.
authors.affiliation: Department of Pathology, Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Sanchez
authors.forename: Houston
authors.initials: H
authors.lastname: Holmes
authors.forename: Nora
authors.initials: N
authors.lastname: Katabi
authors.forename: Joe
authors.initials: J
authors.lastname: Newman
authors.forename: Rana
authors.initials: R
authors.lastname: Domiatti-Saad
authors.forename: Marvin
authors.initials: M
authors.lastname: Stone
authors.forename: George
authors.initials: G
authors.lastname: Netto
mesh_terms: D000368:Aged; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006689:Hodgkin Disease / Q000473:pathology* / Q000821:virology; D006801:Humans; D017403:In Situ Hybridization; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008214:Lymphocytes / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology* / Q000821:virology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000821:virology; D016539:Reed-Sternberg Cells / Q000473:pathology
chemical_list: D004279:DNA, Viral