Serotonergic mechanisms: a potential link between affective disorders and cardiovascular risk.
Cardiovascular disease and major depression are highly prevalent disorders in our society. Evidence has been found that confirms a reciprocal relationship between mechanisms of depression and those of cardiovascular pathology. This possible feedback between both pathologies is a subject of great concern. In recent years some studies suggest that platelets and serotonergic mechanisms could be involved in both conditions. The present review seeks a better understanding of the mechanisms that could link depression with an enhanced cardiovascular risk.
Escolar
Ginés
G
Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Faculty of Medicine, University of Barcelona, Barcelona, Spain. gescolar@clinic.ub.es
Díaz-Ricart
Maribel
M
Gomez-Gil
Esther
E
Serra
Montserrat
M
Gasto
Cristobal
C
Bozzo
Jordi
J
Galán
Ana Maria
AM
D000928:Antidepressive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D019964:Mood Disorders / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D012702:Serotonin Antagonists / Q000627:therapeutic use; D050486:Serotonin Plasma Membrane Transport Proteins / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D012701:Serotonin; D012702:Serotonin Antagonists; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors