title: Secondary hemophagocytic lymphohistiocytosis in Turkish children.
abstract: Between January 1998 and January 2005, a total of 18 children 2 weeks-72 months of age were diagnosed as having secondary hemophagocytic lymphohistiocytosis. The frequency of secondary hemophagocytic lymphohistiocytosis among total hospitalized patients during this period was 0.05% (18 of 34,250). Of the 18 patients, 8 (44.5%) had bacterial infections; cytomegalovirus and Epstein-Barr virus infections were present in 5 (28%) and 1 (5.5%), patient, respectively. Leishmaniasis was diagnosed in 2 patients (11%), and herpes simplex virus was diagnosed in 2 patients (11%). Six patients died during treatment, and 1 patient was lost to follow-up. The survival rate was 61%.
authors.affiliation: Pediatric Hematology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey. agurgey@hacettepe.edu.tr
authors.forename: Aytemiz
authors.initials: A
authors.lastname: Gurgey
authors.forename: Gulten
authors.initials: G
authors.lastname: Secmeer
authors.forename: Betul
authors.initials: B
authors.lastname: Tavil
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ceyhan
authors.forename: Baris
authors.initials: B
authors.lastname: Kuskonmaz
authors.forename: Bulent
authors.initials: B
authors.lastname: Cengiz
authors.forename: Hasan
authors.initials: H
authors.lastname: Ozen
authors.forename: Ates
authors.initials: A
authors.lastname: Kara
authors.forename: Mualla
authors.initials: M
authors.lastname: Cetin
authors.forename: Fatma
authors.initials: F
authors.lastname: Gumruk
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000150:complications / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007896:Leishmaniasis / Q000150:complications* / Q000469:parasitology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D014421:Turkey / Q000453:epidemiology; D014777:Virus Diseases / Q000150:complications* / Q000821:virology