Sulfation and glucuronidation of phenols: implications in coenyzme Q metabolism.
Phase II conjugation of phenolic compounds constitutes an important mechanism through which exogenous or endogenous toxins are detoxified and excreted. Species differences in the rates of glucuronidation or sulfation can lead to significant variation in the metabolism of this class of compounds. Conjugation of the hydroxyl groups of phenols can occur with glucuronate or sulfate. Quinone metabolism, deactivation, and detoxification are also affected by the same conjugatory systems as phenols; however, reduction of quinones to hydroquinols seems to be a prerequisite. This work reviews current knowledge on phenol conjugation and its implications on hydroquinone metabolism with special consideration for coenzyme Q metabolism.
Shangari
Nandita
N
Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada.
Chan
Tom S
TS
O'Brien
Peter J
PJ
D000818:Animals; D020719:Glucuronides / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism*; D006801:Humans; D006873:Hydroquinones / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000378:metabolism*; D015238:Sulfotransferases / Q000378:metabolism*; D014451:Ubiquinone / Q000378:metabolism*; D014535:Uridine Diphosphate Glucuronic Acid / Q000378:metabolism
D020719:Glucuronides; D006873:Hydroquinones; D010636:Phenols; D014451:Ubiquinone; D014535:Uridine Diphosphate Glucuronic Acid; D014453:Glucuronosyltransferase; D015238:Sulfotransferases; C025203:Ubiquinone Q1; C031927:hydroquinone