delta-Lactone from Oedogonium capillare and their effects on rat ileum.
Antispasmodic activity-guided fractionation together with chemical analysis led to the isolation of one novel delta-lactone named oedogonolide from Oedogonium capillare. Identification was based on spectroscopic methods. The oedogonolide produces a significant antispasmodic effect on the contractions of the rat ileum induced by acetylcholine, histamine and barium chloride.
Perez Gutierrez
Rosa Martha
RM
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industias extractivas IPN, Punto fijo 16, col. Torres Lindavista cp 07708, México D.F., México. rmpg@prodigy.net.mx
Rosario Vargas
Solis
S
Martinez Martinez
Francisco
F
Garcia Baez
Efren
E
Figueroa Torres
Guadalupe
G
D000818:Animals; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats
D007783:Lactones