title: Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus.
abstract: An association between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and type 1 diabetes has been described in adults, but not previously in children. Two adolescents with both CIDP and type 1 diabetes are reported here. In order to raise the awareness of CIDP among pediatricians, a description of the clinical and laboratory features, treatment, and prognosis of the condition is provided. A preliminary study was undertaken to determine whether responses to autoantigens in peri-islet Schwann cells and Schwann cells may account for the association between type 1 diabetes and CIDP. Lymphocyte proliferation in response to these autoantigens was abnormal in one of the two patients, but was also abnormal in one control subject.
authors.affiliation: Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fudge
authors.forename: James
authors.initials: J
authors.lastname: Carol
authors.forename: Jin-Xiong
authors.initials: JX
authors.lastname: She
authors.forename: Michael
authors.initials: M
authors.lastname: Dosch
authors.forename: Mark
authors.initials: M
authors.lastname: Atkinson
authors.forename: Andrew
authors.initials: A
authors.lastname: Muir
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D001323:Autoantibodies