Effect of continuous infusion of propofol on its concentration in blood with and without the liver in pigs.
In living donor liver transplantation, propofol, an intravenous anesthetic drug, has recently been used in both donors and recipients. Propofol is known to have intra- and extrahepatic metabolic pathways, but the effect of its continuous infusion during a long-term anhepatic state is yet to be determined. Recently, we successfully established a simplified pig model of the complete anhepatic state. In this state, we first evaluated hemodynamic parameters relating to the pharmacokinetics of continuously infused propofol (6 mg.kg(-1) x h(-1)). No significant changes in the concentration of hemoglobin or in hemodynamic parameters other than the heart rate were observed during the anhepatic phase when porpofol was continuously infused at the rate that maintains the state. Blood propofol concentrations in the mixed vein, artery, and portal vein were stable during the anhepatic phase. Finally, we confirmed the pharmacokinetics of continuously infused propofol using orthotropic liver transplantation in miniature pigs. The propofol concentration did not change markedly during the transplant procedure. In conclusion, the pharmacokinetics of continuously infused propofol was almost stable with and without the liver in pigs. Extrahepatic metabolism of propofol might help prevent changes in propofol concentrations.
Murayama
T
T
Department of Anesthesiology, Jichi Medical School, Tochigi, Japan.
Sato
Y
Y
Wainai
T
T
Enomoto
A
A
Seo
N
N
Yoshino
H
H
Kobayashi
E
E
D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006498:Hepatectomy; D007262:Infusions, Intravenous; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D016031:Liver Transplantation / Q000502:physiology*; D023421:Models, Animal; D010101:Oxygen Consumption / Q000187:drug effects; D015742:Propofol / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology*; D013552:Swine
D018686:Anesthetics, Intravenous; D015742:Propofol