title: Metabolic syndrome negatively impacts early patency of saphenous vein grafts.
abstract: BACKGROUND
  Coronary artery bypass grafting has been performed for a long period utilizing saphenous vein grafts, the fate of which might be crucial to prognosis following the operation. Metabolic syndrome, on the other hand, has become an increasingly important part of cardiovascular practice. We examined whether there was any negative effect of metabolic syndrome on saphenous vein graft patency in a relatively short term (< or =5 years).
  
  
  METHODS
  Coronary angiograms of 314 consecutive patients (mean age 62.6+/-8.5 years), having at least one saphenous vein bypass graft within the last 5 years, were evaluated.
  
  
  RESULTS
  One hundred and twenty-one patients (group 1) had either an occluded saphenous vein graft or a saphenous vein graft with a significant lesion, and 193 patients (group 2) had patent saphenous vein grafts. Metabolic syndrome was present in 46.2% of all patients (n=145), in 57% of patients in group 1 and in 39.4% of patients in group 2 (P=0.002). Having metabolic syndrome increased the risk of saphenous vein graft occlusion or having a significant lesion on saphenous vein grafts by 2.04-folds. In multivariable logistic regression, smoking (P=0.015, odds ratio=1.88), metabolic syndrome (P=0.019, odds ratio=1.81) and diabetes mellitus (P=0.048, odds ratio=1.36) were found to be associated with poor venous graft fate in the relatively short-term period after bypass.
  
  
  CONCLUSIONS
  Metabolic syndrome seems to impact saphenous vein graft patency negatively in the relatively short term.
authors.affiliation: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey. cardioreceptor@gmail.com
authors.forename: Mehmet Birhan
authors.initials: MB
authors.lastname: Yilmaz
authors.forename: Umit
authors.initials: U
authors.lastname: Guray
authors.forename: Yesim
authors.initials: Y
authors.lastname: Guray
authors.forename: Senay Funda
authors.initials: SF
authors.lastname: Biyikoglu
authors.forename: Izzet
authors.initials: I
authors.lastname: Tandogan
authors.forename: Hatice
authors.initials: H
authors.lastname: Sasmaz
authors.forename: Sule
authors.initials: S
authors.lastname: Korkmaz
mesh_terms: D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012501:Saphenous Vein / Q000503:physiopathology* / Q000637:transplantation; D016896:Treatment Outcome; D014654:Vascular Patency / Q000502:physiology*