title: Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages.
abstract: OBJECTIVE
  To improve the effectiveness of boron neutron capture therapy (BNCT) for malignant gliomas, the authors used epithermal rather than thermal neutrons for deep penetration and two boron compounds-sodium borocaptate (BSH) and boronophenylalanine (BPA)-with different accumulation mechanisms to increase the boron level in tumors while compensating for each other's faults.
  
  
  METHODS
  Thirteen patients, 10 of whom harbored a glioblastoma multiforme (GBM), one a gliosarcoma, one an anaplastic astrocytoma, and one an anaplastic oligoastrocytoma, were treated using this modified BNCT between January 2002 and December 2003. Postoperatively, neuroimaging revealed that only one patient with a GBM had no lesion enhancement postoperatively. The patients underwent 18F-BPA positron emission tomography, if available, to assess the accumulation and distribution of BPA before neutron radiotherapy. The neutron fluence rate was estimated using the Simulation Environments for Radiotherapy Applications dose-planning system before irradiation. The patients' volume assessments were performed using magnetic resonance (MR) imaging or computerized tomography (CT) scanning. Improvements in the disease as seen on neuroimages were assessed between 2 and 7 days after irradiation to determine the initial effects of BNCT; its maximal effects were also analyzed on serial neuroimages. The mean tumor volume before BNCT was 42.3 cm3. Regardless of the pre-BNCT tumor volume, in every patient harboring an assessable lesion, improvements on MR or CT images were recognized both at the initial assessment (range of volume reduction rate 17.4-71%, mean rate 46.4%) and at follow-up assessments (range of volume reduction rates 30.3-87.6%, mean rate 58.5%). More than 50% of the contrast-enhanced lesions disappeared in eight of the 12 patients during the follow-up period.
  
  
  CONCLUSIONS
  This modified BNCT produced a good improvement in malignant gliomas, as seen on neuroimages.
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki City, Japan. neu070@poh.osaka-med.ac.jp
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Miyatake
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawabata
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Kajimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Aoki
authors.forename: Kunio
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamada
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kuroiwa
authors.forename: Motomu
authors.initials: M
authors.lastname: Tsuji
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Imahori
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Masunaga
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagata
authors.forename: Akira
authors.initials: A
authors.lastname: Maruhashi
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000532:radiotherapy; D001896:Boron Compounds / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000009:adverse effects / Q000379:methods*; D001929:Brain Edema / Q000175:diagnosis / Q000209:etiology; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy; D005910:Glioma / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D018316:Gliosarcoma / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009502:Neutrons; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D001896:Boron Compounds