title: Iridoid glucosides from the aerial parts of Globularia alypum L. (Globulariaceae).
abstract: From the hydromethanolic extract of the aerial parts of Globularia alypum grown in Morocco, a new chlorinated iridoid glucoside, globularioside has been isolated beside 5 known iridoid glycosides, globularin, globularicisin, globularidin, globularinin and globularimin. This is the first report of a chlorinated iridoid in G. alypum and in the Globulareaceae. Unlike all other known 7-chlorinated iridoid glucosides where the chlorine atom exhibits an alpha configuration, globularioside incorporate the chlorine atom as a 7beta substituent. The structures of the isolated compounds were established on the basis of ESI-MS, MS-MS, 1D and 2D NMR spectral analysis.
authors.affiliation: Unité de Phytopharmacie et Médiateurs Chimiques, INRA, Versailles Cedex, France. nouressafi@yahoo.fr
authors.forename: Nour-Eddine
authors.initials: NE
authors.lastname: Es-Safi
authors.forename: Samira
authors.initials: S
authors.lastname: Khlifi
authors.forename: Albert
authors.initials: A
authors.lastname: Kollmann
authors.forename: Lucien
authors.initials: L
authors.lastname: Kerhoas
authors.forename: Ahmed
authors.initials: A
authors.lastname: El Abbouyi
authors.forename: Paul-Henri
authors.initials: PH
authors.lastname: Ducrot
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds; D002240:Carbohydrate Sequence; D002853:Chromatography, Liquid; D005609:Free Radicals / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D028083:Scrophulariaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D005960:Glucosides; D039823:Iridoids; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl