title: Adult-onset nemaline myopathy and monoclonal gammopathy.
abstract: A 45-year-old man with severe proximal muscle weakness had findings diagnostic of adult-onset nemaline myopathy. He also had a monoclonal gammopathy. This is the fifth report of adult-onset nemaline myopathy in a patient with monoclonal gammopathy, suggesting that the occurrence of these entities may be more than a chance association. Myocyte-bound immunoglobulin or light chains were not detected and immunotherapy was not effective in this patient. Other causes of adult-onset nemaline myopathy were ruled out, including the most common mutations of sarcomeric thin filament genes.
authors.affiliation: Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. chk9021@nyp.org
authors.forename: Christian E
authors.initials: CE
authors.lastname: Keller
authors.forename: Arthur P
authors.initials: AP
authors.lastname: Hays
authors.forename: Lewis P
authors.initials: LP
authors.lastname: Rowland
authors.forename: Behzad
authors.initials: B
authors.lastname: Moghadaszadeh
authors.forename: Alan H
authors.initials: AH
authors.lastname: Beggs
authors.forename: Govind
authors.initials: G
authors.lastname: Bhagat
mesh_terms: D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008875:Middle Aged; D017696:Myopathies, Nemaline / Q000150:complications* / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications* / Q000473:pathology