Acteoside of Callicarpa dichotoma attenuates scopolamine-induced memory impairments.
We previously reported that ten phenylethanoid glycosides including acteoside isolated from the leaves and twigs of Callicarpa dichotoma significantly attenuated glutamate-induced neurotoxicity. In the present study, we examined anti-amnesic activity of acteoside using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and Morris water maze tests. Acute oral treatment (single administration prior to scopolamine treatment) of mice with acteoside (1.0, 2.5 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in the passive avoidance test. It is interesting to note that prolonged oral daily treatment of mice with much lower amount (0.1 mg/kg body weight) of acteoside for 10 d reversed the scopolamine-induced memory deficits. In the Morris water maze, prolonged oral treatment with acteoside (prolonged daily administration of 1.0 mg/kg body weight for 10 d) significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. We suggest, therefore, that acteoside has anti-amnesic activity that may ultimately hold significant therapeutic value in alleviating certain memory impairment observed in Alzheimer's disease.
Lee
Ki Yong
KY
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Kore, Seoul, Korea.
Jeong
Eun Ju
EJ
Lee
Heum-Sook
HS
Kim
Young Choong
YC
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D032408:Callicarpa / Q000737:chemistry*; D003071:Cognition / Q000187:drug effects; D005960:Glucosides / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D018727:Muscarinic Antagonists / Q000633:toxicity*; D010636:Phenols / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D059808:Polyphenols
D005960:Glucosides; D018727:Muscarinic Antagonists; D010636:Phenols; D012601:Scopolamine; C058956:acteoside; D059808:Polyphenols