title: Relationship between plasma concentrations of cytokines, ratio of CD4 and CD8, lymphocyte proliferative responses, and depressive and anxiety state in bulimia nervosa.
abstract: OBJECTIVE
  Immunological dysfunction in participants with bulimia nervosa (BN) might be due to not only chaotic eating behavior but also psychological state, such as depression and anxiety, because studies have found a close relationship between depression, anxiety, and immunological dysfunction.
  
  
  METHODS
  Participants included 20 females with BN and 14 control females. In eight BN participants, immune function was measured twice, before and after inpatient treatment. Cytokines [interleukin (IL)-1 receptor antagonist, IL-2 soluble receptor alpha, IL-6 soluble receptor (sIL-6r), and tumor necrosis factor soluble receptor II (sTNF-rII)], lymphocyte subsets (CD4 and CD8), and lymphocyte proliferative responses were measured.
  
  
  RESULTS
  There were no differences in plasma cytokine levels or lymphocyte subsets between the BN participants and the controls. Conversely, lymphocyte proliferative responses were significantly lower in BN participants than in the controls. Lymphocyte proliferative responses negatively correlated with anxiety trait and improved with an improvement of bulimic state.
  
  
  CONCLUSIONS
  The comorbid nonspecific anxiety trait significantly contributes to suppressing lymphocyte proliferative responses in BN participants.
authors.affiliation: Department of Neuropsychiatry, Osaka City University Medical School, 1-4-3 Asahimachi, Abunoku, Osaka 545-8585, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Nagata
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamada
authors.forename: Toshiya
authors.initials: T
authors.lastname: Iketani
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kiriike
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D052018:Bulimia Nervosa / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D015704:CD4 Antigens / Q000097:blood* / Q000276:immunology; D016827:CD8 Antigens / Q000097:blood* / Q000276:immunology; D049109:Cell Proliferation; D003710:Demography; D003866:Depressive Disorder / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology*; D008297:Male
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D007375:Interleukin-1; D015850:Interleukin-6