ABC lipid transporters: extruders, flippases, or flopless activators?
Many mammalian ABC transporters move membrane lipids to acceptor lipid assemblies in the extracellular aqueous milieu. Because the desorption from the membrane costs more energy than provided by two ATPs, the transporter probably only translocates the lipid to a partially hydrophilic site on its extracellular face. From this high-energy site, the lipid may efficiently move to the acceptor, which ideally is bound to the transporter, or, in the absence of an acceptor, fall back into the membrane. If the lipid originated from the cytosolic membrane surface, this represents lipid flop and is probably a side activity of the transporters.
van Meer
Gerrit
G
Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. g.vanmeer@chem.uu.nl
Halter
David
D
Sprong
Hein
H
Somerharju
Pentti
P
Egmond
Maarten R
MR
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D050356:Lipid Metabolism; D008052:Lipid Metabolism, Inborn Errors / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters