Heat-epimerized tea catechins have the same cholesterol-lowering activity as green tea catechins in cholesterol-fed rats.
Tea catechins are known to be epimerized by heat treatment. The effect of heat-epimerized tea catechins on serum cholesterol concentration was compared with that of green tea catechins. Our observations strongly suggest that both tea catechins and heat-epimerized tea catechins lower serum cholesterol concentration by inhibiting cholesterol absorption in the intestine. There was no differential effect between the two catechin preparations.
Kobayashi
Makoto
M
Central Research Institute, Ito En, Ltd., Shizuoka, Japan. m-kobayasi@itoen.co.jp
Unno
Tomonori
T
Suzuki
Yuko
Y
Nozawa
Ayumu
A
Sagesaka
Yuko
Y
Kakuda
Takami
T
Ikeda
Ikuo
I
D000818:Animals; D000924:Anticholesteremic Agents; D001835:Body Weight / Q000187:drug effects; D002392:Catechin / Q000737:chemistry* / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D006358:Hot Temperature; D007408:Intestinal Absorption / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D013662:Tea / Q000737:chemistry*
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008055:Lipids; D013662:Tea; D002392:Catechin; D002784:Cholesterol