5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis.
Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.
Upcroft
Jacqueline A
JA
The Queensland Institute of Medical Research and ACITHN, P.O. Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Jacqui.Upcroft@qimr.edu.au
Dunn
Linda A
LA
Wright
Janelle M
JM
Benakli
Kamel
K
Upcroft
Peter
P
Vanelle
Patrice
P
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004351:Drug Resistance; D016829:Giardia lamblia / Q000187:drug effects*; D008795:Metronidazole / Q000494:pharmacology*; D008970:Molecular Weight; D009593:Nitroimidazoles / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000981:Antiprotozoal Agents; D009593:Nitroimidazoles; D008795:Metronidazole