title: Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology.
abstract: OBJECTIVE
  the aim of the study was to investigate size control of amphiphilic beta-cyclodextrin nanoparticles obtained by solvent displacement technique.
  
  
  METHODS
  An experimental design methodology for mixture design was undertaken using D-optimal approach with the following technique variables: water fraction X1 (40-70% v/v), acetone fraction X2 (0-60% v/v) and ethanol fraction X3 (0-60% v/v).
  
  
  RESULTS
  The resulting quadratic model obtained after logarithmic transformation of data and partial least-square regression was statistically validated and experimentally checked. Also, the morphology of the colloidal nanoparticles from selected experiments was observed by cryo-transmission electron microscopy.
  
  
  CONCLUSIONS
  This experimental design approach allowed to produce interesting amphiphilic beta-cyclodextrin nanoparticles with a predicted mean size varying from 60 to 400 nm.
authors.affiliation: Université Joseph Fournier, UFR Pharmacie, DPM UMR CNRS 5063, Pharmacotechnie, Avenue de Verdun, Meylan Cedex. luc.choisnard@ujf-grenoble.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Choisnard
authors.forename: Annabelle
authors.initials: A
authors.lastname: Géze
authors.forename: Muriel
authors.initials: M
authors.lastname: Bigan
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Putaux
authors.forename: Denis
authors.initials: D
authors.lastname: Wouessidjewe
mesh_terms: D003505:Cyclodextrins / Q000138:chemical synthesis*; D015195:Drug Design; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D003505:Cyclodextrins