title: Distribution of cervical intraepithelial neoplasia 2, 3 and cancer on the uterine cervix.
abstract: OBJECTIVE
  To determine the distribution of cervical intraepithelial neoplasia 2 or 3 on the uterine cervix.
  
  
  METHODS
  During two screening studies, 5,060 women underwent colposcopy with biopsy. If a cervical quadrant had no lesion, a random biopsy at the squamocolumnar junction was obtained.
  
  
  RESULTS
  Cervical intraepithelial neoplasia 2 or worse was more common on the posterior (426/806; 52.9%) than on the anterior (380/806; 47.2%) cervix (p < .05) and was equally likely on the right (411/806; 51.0%) and left (395/806; 49.0%) sides of the cervix. More quadrants with colposcopically detected lesions of human papillomavirus or worse came from the anterior (1,338; 57.5%) than posterior (991; 42.6%) cervix (p < .05), whereas similar numbers of these lesions were found on the left (1,163) and right (1,166) sides of the cervix.
  
  
  CONCLUSIONS
  Cervical intraepithelial neoplasia 2 or worse is slightly more common on the posterior cervix. Using colposcopically detected lesions as a surrogate for cervical intraepithelial neoplasia 2 or worse inflates the prevalence of cervical intraepithelial neoplasia on the anterior cervix.
authors.affiliation: Department of Obstetrics and Gynecology, Southern California Permanente Medical Group, Fontana, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Pretorius
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Belinson
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhang
authors.forename: Shen-Da
authors.initials: SD
authors.lastname: Ren
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Bao
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
mesh_terms: D000328:Adult; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012720:Severity of Illness Index; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*