title: The serotonergic system and its role in cocaine addiction.
abstract: Cocaine is an alkaloid with psychostimulant action and high addictive potential. It possesses high affinity for the transporters of dopamine, serotonin (5-HT) and noradrenaline, and blocks reuptake of the above-mentioned monoamines. The present review summarized the contribution of 5-HT neurotransmitter system to rewarding and aversive properties of cocaine, to cocaine withdrawal and its long-term abuse. The present state of knowledge of 5-HT neurotransmission justifies the opinion that pharmacological manipulation in the 5-HT system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse.
authors.affiliation: Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. filip@if-pan.krakow.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Filip
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Frankowska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zaniewska
authors.forename: Anna
authors.initials: A
authors.lastname: Gołda
authors.forename: Edmund
authors.initials: E
authors.lastname: Przegaliński
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000009:adverse effects* / Q000378:metabolism; D003042:Cocaine / Q000009:adverse effects* / Q000378:metabolism; D019970:Cocaine-Related Disorders / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D006801:Humans; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D009435:Synaptic Transmission
chemical_list: D000697:Central Nervous System Stimulants; D050483:Dopamine Plasma Membrane Transport Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; D003042:Cocaine