title: SEN virus prevalence among non-B and non-C hepatitis patients with high liver function tests in the south of Turkey.
abstract: We investigated the characteristics and detection rates of SEN virus (SENV) infection among 100 Turkish patients who had with high alanine aminotransferase (ALT) and aspartate aminotransferase levels but were negative for HBV DNA and HCV RNA and had no history of transfusion. As a control group, we also analyzed 50 healthy individuals who had normal ALT levels, were negative for HBV DNA and HCV RNA, and had no history of transfusion. The serum samples of patient and controls were analyzed by PCR to detect the presence of SENV DNA and its two genotypes (SENV-H and SENV-D). We detected SENV DNA in 13 of 100 (13%) patients. Five of 13 (38.46%) patients were positive for SENV-D and 8 of 13 (61.53%) patients were positive for SENV-H DNA. We also detected SENV DNA in 5 of 50 (10%) patients in the control group. Two of 5 (40%) patients were positive for SENV-D and 3 of 5 (60%) patients were positive for SENV-H DNA in the control group. SENV was detected at almost the same frequency in the patient and control group. SENV did not seem to contribute to the pathogenesis of liver disease (P > 0.05) in this cohort. Our results also showed that SENV transmission was not only associated with blood transfusion but also with some other possible routes.
authors.affiliation: Department of Microbiology, University of Mersin, Mersin, Turkey. serinm@mersin.edu.tr
authors.forename: Mehmet S
authors.initials: MS
authors.lastname: Serin
authors.forename: Fatih
authors.initials: F
authors.lastname: Koksal
authors.forename: Murat
authors.initials: M
authors.lastname: Oksuz
authors.forename: Bahri
authors.initials: B
authors.lastname: Abayli
authors.forename: Gonul
authors.initials: G
authors.lastname: Aslan
authors.forename: Seda
authors.initials: S
authors.lastname: Tezcan
authors.forename: Cilem
authors.initials: C
authors.lastname: Yildiz
authors.forename: Begum
authors.initials: B
authors.lastname: Kayar
authors.forename: Gurol
authors.initials: G
authors.lastname: Emekdas
mesh_terms: D000328:Adult; D004266:DNA Virus Infections / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D008099:Liver / Q000502:physiology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D022783:Torque teno virus / Q000302:isolation & purification*; D014421:Turkey / Q000453:epidemiology
chemical_list: D004279:DNA, Viral