Mouse models for HIV-1 infection.
The generation of small animal models, which preserve the ability for the generation of primary and memory immune responses of the engrafted human immune cells and in which a robust HIV-1 infection may occur, may enable the rapid screening, development and evaluation of HIV-1 protective vaccines and adjuvants. This manuscript reviews the existing mouse HIV-1 models used to study virologic, immunologic and pathogenic aspects of HIV-1 infection and disease and discusses their limitations and advantages, especially in the context of vaccine development, with special focus on the recently developed Trimera-HIV-1 animal model.
Borkow
Gadi
G
Cupron Inc., Kfar Gibton, Israel. gadi@cupron.com
D016915:AIDS Vaccines; D000818:Animals; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology* / Q000517:prevention & control; D015497:HIV-1; D051379:Mice; D008817:Mice, Mutant Strains
D016915:AIDS Vaccines