title: Melioidotic osteomyelitis treated with antibiotic-calcium hydroxyapatite composite: case report with four-year follow-up.
abstract: Melioidosis is caused by an infection by Burkholderia pseudomallei. Osteomyelitis is a recognised manifestation of melioidosis but Burkholderia pseudomallei is a relatively rare aetiological agent in musculoskeletal infections. We report a 32-year-old diabetic man with septicaemia due to melioidotic infection of the spleen, liver and distal femur. The osteomyelitis relapsed despite being treated with the standard radical debridement and insertion of gentamycinimpregnated polymethylmetacrylate (PMMA) beads, followed by an optimal antibiotic therapy. The PMMA-gentamycin beads were then removed. The bone defect was debrided and packed with calcium hydroxyapatite blocks filled with ceftazidime powder. The osteomyelitis was successfully treated and the patient remained free of infection four years postoperatively. Computed tomography demonstrated successful incorporation of the calcium hydroxyapatite into host bone.
authors.affiliation: Unit of Orthopaedic Surgery, Department of Surgery, Faculty of Medicine and Health Sciences, University Putra Malaysia, 50250 Kuala Lumpur, Malaysia.
authors.forename: W M
authors.initials: WM
authors.lastname: Ng
authors.forename: M K
authors.initials: MK
authors.lastname: Kwan
authors.forename: A M
authors.initials: AM
authors.lastname: Merican
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016957:Burkholderia pseudomallei / Q000302:isolation & purification; D002442:Ceftazidime / Q000008:administration & dosage*; D004333:Drug Administration Routes; D017886:Durapatite; D005269:Femur / Q000382:microbiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008554:Melioidosis / Q000188:drug therapy*; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents; D017886:Durapatite; D002442:Ceftazidime