title: Analytical theory of the stochastic dynamics of the power stroke in nonprocessive motor proteins.
abstract: Statistical distributions of the structural states of individual molecules of nonprocessive motor complexes such as actomyosins are examined theoretically by considering a two-state stochastic model coupled by chemical reactions along the reaction coordinate representing the internal conformational states of the motor. The use of a conformational reaction coordinate allows for the approximation of taking the rate constants as local in their dependence on the reaction coordinate, and yields a simple analytic solution of the stationary states. The approximation is also tested against numerical solutions with a nonlocal form of rate constants. The theory is well-suited for computational treatments based on atomic structures of protein constituents using free energy molecular dynamics simulations. With empirical sets of free energy functions, stationary distributions of forces exerted by a motor head compare well with known experimental data.
authors.affiliation: Department of Chemistry, University of Nevada, Reno, Nevada 89557, USA. woo.chem.unr.edu
authors.forename: H J
authors.initials: HJ
authors.lastname: Woo
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Moss
mesh_terms: D000199:Actins / Q000737:chemistry* / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D015233:Models, Statistical; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000502:physiology*; D009038:Motion; D009068:Movement / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000737:chemistry / Q000502:physiology; D009218:Myosins / Q000737:chemistry* / Q000502:physiology*; D013269:Stochastic Processes; D013314:Stress, Mechanical
chemical_list: D000199:Actins; D020409:Molecular Motor Proteins; D009218:Myosins