title: Malondialdehyde level and adenosine deaminase activity in nasal polyps.
abstract: OBJECTIVE
  Although there are many reports on adenosine deaminase (ADA) activities in different tissues, no information is available about the enzyme activity in nasal mucosa and polyp tissues. Whereas ADA is related to the production of free radicals by neutrophils, malondialdehyde (MDA) is an indicator of lipid peroxidation that is a general mechanism of tissue damage by free radicals. This study is aimed at determining and comparing the ADA activity and MDA level in nasal polyps and normal mucosa.
  
  
  METHODS
  Twenty-three patients with nasal polyps and a control group consisting of 14 patients with septal deviation and lower turbinate hypertrophy were included in the study. Tissue MDA level was measured by the method of Okawa with modification and tissue ADA activity by the method of Giusti.
  
  
  RESULTS
  In patients with nasal polyp, mean tissue MDA level and ADA activity were 2.43 +/- 0.38 nmol/mg protein (Pr) and 0.235 +/- 0.055 U/mg Pr, respectively, which were significantly higher than those of control nasal mucosa (1.03 +/- 0.41 nmol/mg protein and 0.056 +/- 0.011 U/mg Pr, respectively) (P < 0.05). In addition, tissue MDA level was positively correlated to ADA activity in nasal polyps (r = 0.701, P < 0.001).
  
  
  CONCLUSIONS
  The present study showed the presence of detectable ADA activity in nasal mucosa, and also significant increases in both tissue MDA level and ADA activity in NP tissue when compared to normal turbinate tissue.
  
  
  METHODS
  B-2b.
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, Kahramanmaras Sutcu Imam University, Hastane Cad. No. 32, 46050-Kahramanmaras, Turkey. erdoganokur@yahoo.com
authors.forename: Erdogan
authors.initials: E
authors.lastname: Okur
authors.forename: Fatma
authors.initials: F
authors.lastname: Inanc
authors.forename: Ilhami
authors.initials: I
authors.lastname: Yildirim
authors.forename: Metin
authors.initials: M
authors.lastname: Kilinc
authors.forename: M Akif
authors.initials: MA
authors.lastname: Kilic
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism* / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism*; D008875:Middle Aged; D009297:Nasal Mucosa / Q000201:enzymology; D009298:Nasal Polyps / Q000201:enzymology* / Q000209:etiology; D014420:Turbinates / Q000201:enzymology
chemical_list: D008315:Malondialdehyde; D000243:Adenosine Deaminase