title: Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate.
abstract: Recently a novel family of putative nitric oxide synthases, with AtNOS1, the plant member implicated in NO production, has been described. Here we present experimental evidence that a mammalian ortholog of AtNOS1 protein functions in the cellular context of mitochondria. The expression data suggest that a candidate for mammalian mitochondrial nitric oxide synthase contributes to multiple physiological processes during embryogenesis, which may include roles in liver haematopoesis and bone development.
authors.affiliation: Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany. zemojtel@molgen.mpg.de
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zemojtel
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kolanczyk
authors.forename: Nadine
authors.initials: N
authors.lastname: Kossler
authors.forename: Sigmar
authors.initials: S
authors.lastname: Stricker
authors.forename: Rudi
authors.initials: R
authors.lastname: Lurz
authors.forename: Ivan
authors.initials: I
authors.lastname: Mikula
authors.forename: Marlena
authors.initials: M
authors.lastname: Duchniewicz
authors.forename: Markus
authors.initials: M
authors.lastname: Schuelke
authors.forename: Pedram
authors.initials: P
authors.lastname: Ghafourifar
authors.forename: Pavel
authors.initials: P
authors.lastname: Martasek
authors.forename: Martin
authors.initials: M
authors.lastname: Vingron
authors.forename: Stefan
authors.initials: S
authors.lastname: Mundlos
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D004622:Embryo, Mammalian / Q000033:anatomy & histology; D006801:Humans; D017403:In Situ Hybridization; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000201:enzymology* / Q000648:ultrastructure; D008969:Molecular Sequence Data; D041681:NIH 3T3 Cells; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism*; D021382:Protein Sorting Signals; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D014018:Tissue Distribution
chemical_list: D007527:Isoenzymes; D021382:Protein Sorting Signals; D011993:Recombinant Fusion Proteins; D019001:Nitric Oxide Synthase