title: A rare ganglioneuroblastoma secreting dopamine and the value of its measurement in diagnosis and prognosis.
abstract: A case is described of a patient with a ganglioneuroblastoma, initially located in the right adrenal, which produced an excess of dopamine (7646 and 7959 nmol/24 h), approximately two and a half times the upper limit of the normal daily urine output. The urinary excretion of noradrenaline, adrenaline and methylated derivatives was always within the normal reference ranges. The patient was generally well, with normal blood pressure and only mild flushes. Two years after surgical resection, recurrence was indicated by an increase in urinary dopamine (8507 nmol/24 h); it was located in the tumour bed and left side of the neck by CT and (123)I MIBG scans. The patient was treated with a high dose of (131)I MIBG, with subsequent reduction in dopamine production. This was repeated on four other occasions, the latest being in January 2005. The output of dopamine was thus used as a marker of tumour diagnosis and progression and it is recommended that the assay of dopamine be included in the screening of catecholamine-secreting tumours to avoid possible misdiagnosis.
authors.affiliation: Department of Clinical Biochemistry & Metabolic Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool, UK.
authors.forename: M
authors.initials: M
authors.lastname: Sargazi
authors.forename: M L
authors.initials: ML
authors.lastname: Smith
authors.forename: R C
authors.initials: RC
authors.lastname: Worth
authors.forename: N B
authors.initials: NB
authors.lastname: Roberts
mesh_terms: D004298:Dopamine / Q000378:metabolism*; D005260:Female; D018305:Ganglioneuroblastoma / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis
chemical_list: D004298:Dopamine