NO-releasing zeolites and their antithrombotic properties.
Transition metal-exchanged zeolite-A adsorbs and stores nitric oxide in relatively high capacity (up to 1 mmol of NO/g of zeolite). The stored NO is released on contact with an aqueous environment under biologically relevant conditions of temperature and pH. The release of the NO can be tuned by altering the chemical composition of the zeolite, by controlling the amount of water contacting the zeolite, and by blending the zeolite with different polymers. The high capacity of zeolite for NO makes it extremely attractive for use in biological and medical applications, and our experiments indicate that the NO released from Co-exchanged zeolite-A inhibits platelet aggregation and adhesion of human platelets in vitro.
Wheatley
Paul S
PS
School of Chemistry, University of St. Andrews, Purdie Building, UK.
Butler
Anthony R
AR
Crane
Michael S
MS
Fox
Sarah
S
Xiao
Bo
B
Rossi
Adriano G
AG
Megson
Ian L
IL
Morris
Russell E
RE
D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D020030:Nitric Oxide Donors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction; D017641:Zeolites / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D005343:Fibrinolytic Agents; D020030:Nitric Oxide Donors; D017641:Zeolites