Evaluation of nailfold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus.
OBJECTIVE
Nailfold capillaroscopy (NFC) has been shown to have a remarkable value in the differential diagnosis of connective tissue diseases. In fact, NFC patterns reflect the microvascular changes that may play a significant role in pathogenesis. The aims of this study were to determine in patients with systemic lupus erythematosus (SLE) the prevalence of NFC patterns, to evaluate any association with clinical features and laboratory parameters.


METHODS
One hundred twenty-three patients with SLE were included in this retrospective study. Video NFC parameters were analyzed in each patient. In all cases, the following parameters were evaluated: capillary arrangement, density, size, and shape.


RESULTS
In patients with SLE, major capillary abnormalities were frequently observed (44 of 123 = 35.8%); however, no specific pattern was noted. There was a significant correlation between the SLEDAI index and the severity of capillary abnormalities (P < 0.0001). Pathologic capillary abnormalities were also significantly increased in SLE with positive anti-U1-RNP antibodies (P < 0.05).


CONCLUSIONS
NFC may be a useful method to evaluate the microvascular changes in patients with SLE, and the presence of major capillary abnormalities seems to herald a more severe clinical course of the illness.
Ingegnoli
Francesca
F
Department of Rheumatology, Istituto Gaetano Pini, Milano, Chair of Rheumatology, University of Milano, Italy. francesca.ingegnoli@unimi.it
Zeni
Silvana
S
Meani
Laura
L
Soldi
Amedeo
A
Lurati
Alfredo
A
Fantini
Flavio
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D002196:Capillaries / Q000648:ultrastructure*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008297:Male; D020678:Microscopic Angioscopy / Q000379:methods*; D008875:Middle Aged; D009262:Nails / Q000098:blood supply*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014741:Video Recording