title: The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling.
abstract: The Grb2 associated binder (Gab) adaptor/scaffolding protein family comprises conserved proteins: mammalian Gab1, Gab2 and Gab3, Drosophila Dos and Caenorhabditis elegans Soc1. Gab adaptors are involved in multiple signaling pathways mediated by receptor- and non-receptor protein tyrosine kinases (PTKs), and become phosphorylated upon stimulation by growth factors-, cytokines-, Ig Fc- and antigen receptors. Through its phosphorylated tyrosine containing motifs, proline-rich sequences and pleckstrin homologue (PH) domain Gab adaptors may generate an interacting platform for proteins with SH2 and SH3 domains and may transfer these molecules to the plasma membrane, thereby contributing to their activation. This review will concentrate on the function of mammalian Gab proteins in the signal transduction triggered by immune receptors.
authors.affiliation: Eötvös Loránd University, Department of Immunology, Pázmány Péter Sétány 1/c, Budapest 1117, Hungary. sarmayg@cerberus.elte.hu
authors.forename: Gabriella
authors.initials: G
authors.lastname: Sármay
authors.forename: Adrienn
authors.initials: A
authors.lastname: Angyal
authors.forename: Akos
authors.initials: A
authors.lastname: Kertész
authors.forename: Máté
authors.initials: M
authors.lastname: Maus
authors.forename: Dávid
authors.initials: D
authors.lastname: Medgyesi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D010766:Phosphorylation; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D011971:Receptors, Immunologic; C098587:GAB1 protein, human; C490895:GAB2 protein, human; C443673:GAB3 protein, human