The immune system and neuropsychiatric diseases.
The immune system has a complex and dynamic relationship with the nervous system, both in health and disease. The immune system surveys the central and peripheral nervous systems, becoming activated in response to foreign substances, infectious particles or neoplasms. Conversely, the nervous system modulates immune system function both through the neuroendocrine axis and through vagus nerve efferents. In disease states, this dynamic relationship is perturbed, resulting in neuropsychiatric diseases. In this manuscript, we will summarize fundamental principles of the immune system and its interaction with the nervous system. We will describe the critical components of the adaptive and innate branches of the immune system and will describe important effectors and signalling pathways in each. By understanding the principles of the immune system and how these principles relate to nervous system function, the reader will be prepared to interpret subsequent manuscripts in this issue.
Kerr
Douglas
D
Department of Neurology, Johns Hopkins Hospital, 600 N. Wolfe St, Pathology 627C, Baltimore MD 21287, USA. dkerr@jhmi.edu
Krishnan
Chitra
C
Pucak
Michele L
ML
Carmen
Jessica
J
D001921:Brain / Q000503:physiopathology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007113:Immunity, Innate / Q000276:immunology; D007239:Infections / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D009420:Nervous System / Q000503:physiopathology*; D009490:Neurosecretory Systems / Q000503:physiopathology; D011598:Psychoneuroimmunology; D014630:Vagus Nerve / Q000503:physiopathology
D016207:Cytokines