[Ultrastructural manifestations of disturbances of cardiomyocyte regeneration after the doxorubicin treatment].
The pattern of cardiomyocyte intracellular reorganization following administration of a antibiotic of anthracyclin series, doxorubicin, was studied. Cardiomyocyte injury following doxorubicin treatment included a triad of ultrastructural changes: nuclear deformation with a reorganization of nucleolar apparatus; diffuse and fine focal lysis of myofibrils, and a dilation of agranular sarcoplasmic reticulum with an associated perinuclear space. As the terminal stages of such disturbances, atrophy of some part of cardiomyocytes, their apoptotoc death and a resorption by mononuclear cells were found, which are the processes demonstrating successive stages of development of regenerative-plastic myocardial insufficiency and resulting in a dilation remodeling of the heart.
Lushnikova
E L
EL
Nepomniashchich
L M
LM
Klinnikova
M G
MG
Molodykh
O P
OP
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004317:Doxorubicin / Q000633:toxicity*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin