Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder.
Glycogen synthase kinase-3beta (GSK-3beta) has been implicated in the pathogenesis of major psychoses. In this paper, the T-50C polymorphism of the GSK-3beta gene has been studied in patients with schizophrenia (n=432), patients with bipolar disorder (n=416) and in a healthy control group (n=408). Consensus diagnosis by at least two psychiatrists was made for each patient, according to DSM-IV and ICD-10 criteria, using the Structured Clinical Interview for DSM-IV Axis I Disorders. Genotypes were established by the polymerase chain reaction-restriction fragment length polymorphism method. We have found a trend towards an association for the C allele in the whole group of schizophrenic patients (p=0.088) and for the heterozygous T/C genotype of bipolar patients (0.095). Significant differences of genotype distribution and allele frequencies of the T-50C polymorphism were found in the female group of bipolar II patients (p=0.015 for genotypes and p=0.009 for alleles). In conclusion, this polymorphism may be associated with female gender in bipolar II disorder.
Szczepankiewicz
Aleksandra
A
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. alszczep@amp.edu.pl
Skibinska
Maria
M
Hauser
Joanna
J
Slopien
Agnieszka
A
Leszczynska-Rodziewicz
Anna
A
Kapelski
Paweł
P
Dmitrzak-Weglarz
Monika
M
Czerski
Piotr M
PM
Rybakowski
Janusz K
JK
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D001714:Bipolar Disorder / Q000145:classification / Q000201:enzymology* / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012016:Reference Values; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*; D012737:Sex Factors; D018709:Statistics, Nonparametric
C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3