[Association of TNFA-308 gene polymorphisms with susceptibility to chronic periodontitis in Chinese patients].
OBJECTIVE
The purpose of this study was to investigate the relationship between TNFalpha-308 gene polymorphisms and susceptibility to chronic periodontitis in Chinese patients.


METHODS
DNA samples with buccal swabs were collected from 63 severe CP patients, 103 initial to moderate CP patients, and 80 healthy controls in Chinese Han nationality. The TNFA-308 gene polymorphisms were analyzed with PCR-RFLP. The data were analyzed by X(2) test using SPSS10.0.


RESULTS
There were no significant genotype distribution differences of TNFA-308 between either two of the three subject groups.


CONCLUSIONS
Further study was needed since we did not find the relationship between TNFA-308 gene polymorphism and periodontitis in this present study.
Pang
Ruo-yu
RY
Guangdong Provincial Hospital of Stomatology, Affiliated Stomatological Hospital of Nanfang Medical University, Guangzhou 510280, Guangdong Province, China.
Chen
Kai-yun
KY
Zhang
Jin-cai
JC
Xu
Chen-rong
CR
Zhang
Xiong
X
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha