Scandium triflate catalyzed cycloaddition of imines with 1,1-cyclopropanediesters: efficient and diastereoselective synthesis of multi-substituted pyrrolidines.
A tandem ring-opening-cyclization reaction of cyclopropanes with imines in the presence of 5 mol% of scandium triflate was developed for the highly diastereoselective synthesis of multi-substituted pyrrolidines.
Kang
Yan-Biao
YB
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Tang
Yong
Y
Sun
Xiu-Li
XL
D002384:Catalysis; D003998:Dicarboxylic Acids / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis*; D012538:Scandium / Q000737:chemistry; D013237:Stereoisomerism
D003998:Dicarboxylic Acids; D007097:Imines; D008698:Mesylates; D011759:Pyrrolidines; C436603:scandium triflate; C069173:1,1-cyclopropanedicarboxylate; D012538:Scandium