Hemodynamic effects of bupropion in anesthetized dogs.
Bupropion is a non-nicotinic drug used in smoking cessation therapy. However, its acute effects remain unclear. In this study, we investigated the effects of bupropion on hemodynamic parameters in pentobarbital-anesthetized mongrel dogs. Bupropion administered either in bolus injections (3 or 6 mg/kg, i.v.) or in cumulative doses of 0.01, 0.1, 1, 3 and 10 mg/kg showed, in both studies, a significant increase of mean pulmonary arterial pressure and pulmonary vascular resistance index. These results show that bupropion can elevate the pulmonary pressure. Further investigations should be done to test this effect in smokers with chronic obstructive pulmonary disease.
Paganelli
Maria Ondina
MO
Cardiovascular Pharmacology and Hypertension Division, Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), SP, Brazil.
Tanus-Santos
José Eduardo
JE
Sabha
Maricene
M
do Prado
Joaquim Francisco
JF
Chaud
Marco Vinicíus
MV
Martins
Luís Cláudio
LC
Moreno
Heitor
H
D000771:Anesthesia, Intravenous; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D016642:Bupropion / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects*
D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D010424:Pentobarbital