title: Meprobamate-tranquilizer or anxiolytic? A historical perspective.
abstract: Meprobamate was the first successful anti-anxiety drug of the modern era. On the 50th anniversary of its introduction, the authors trace the development of its synthesis, marketing and runaway success to understand the scientific and socio-political factors that may have shaped its use in clinical psychiatry. The relationship of this drug to the earlier development of chlorpromazine is explored to clarify the imperatives of drug classification in modern psychiatry.
authors.affiliation: Psychiatry, Drexel University College of Medicine, Philadelphia, PA, USA. dr36@drexel.edu
authors.forename: Dilip
authors.initials: D
authors.lastname: Ramchandani
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Muñoz
authors.forename: Cecilio
authors.initials: C
authors.lastname: Alamo
mesh_terms: D014151:Anti-Anxiety Agents / Q000266:history*; D001008:Anxiety Disorders / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008620:Meprobamate / Q000266:history*; D014149:Tranquilizing Agents / Q000266:history*; D014481:United States
chemical_list: D014151:Anti-Anxiety Agents; D014149:Tranquilizing Agents; D008620:Meprobamate