title: Accuracy of an electronic monitoring and reminder device for use with travoprost eye drops.
abstract: OBJECTIVE
  To evaluate the accuracy of a prototype electronic device for recording eye drop usage.
  
  
  METHODS
  Ten volunteers were randomly assigned to one of five usage patterns designed to mimic common patterns of use in glaucoma patients from 100% compliant to 50% compliant. All participants agreed to adhere to a pre-determined "dosing" schedule for 15 days using the monitoring/reminder device to instill artificial tears. Participants also recorded drop usage in a diary. The main outcome measures were device accuracy and reproducibility. Device accuracy was defined as the magnitude of the difference between the diary and device output for three variables: date, number of drops, and instillation time.
  
  
  RESULTS
  Date stamping by the device was 100% accurate. The mean +/- SD time difference between the device and the diary was -2.0 +/- 19.7 minutes when data from all participants was pooled. In seven of the ten participants, the device did not record at least one drop. The mean +/- SD difference in the number of drops recorded by the device minus the diary was 0.16 +/- 0.97 when data from all participants was pooled.
  
  
  CONCLUSIONS
  The prototype compliance reminder/monitoring device may underestimate compliance in some patients. The date and time stamping mechanisms were generally accurate and reproducible.
authors.affiliation: Hamilton Glaucoma Center, Department of Ophthalmology, University of California at San Diego, La Jolla, USA. cboden@eyecenter.ucsd.edu
authors.forename: Catherine
authors.initials: C
authors.lastname: Boden
authors.forename: Arthur
authors.initials: A
authors.lastname: Sit
authors.forename: Robert N
authors.initials: RN
authors.lastname: Weinreb
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004363:Drug Utilization; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D010349:Patient Compliance; D015203:Reproducibility of Results; D000069557:Travoprost
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D003008:Cloprostenol; D000069557:Travoprost