title: Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis.
abstract: This paper reports on a novel continuous-flow hydrogenation reactor and its integration with a liquid handler to generate a fully automated high-throughput hydrogenation system for library synthesis. The reactor, named the H-Cube, combines endogenous hydrogen generation from the electrolysis of water with a continuous flow-through system. The system makes significant advances over current batch hydrogenation reactors in terms of safety, reaction validation efficiency, and rates of reaction. The hydrogenation process is described along with a detailed description of the device's main parts. The reduction of a series of functional groups, varying in difficulty up to 70 degrees C and 70 bar are also described. The paper concludes with the integration of the device into an automated liquid handler followed by the reduction of a nitro compound in a high throughput manner. The system is fully automated and can conduct 5 reactions in the time it takes to perform and workup one reaction manually on a standard batch reactor.
authors.affiliation: Thales Nanotechnology, Inc., H-1031, Budapest, Zahony u.7, Hungary. richard.jones@thalesnano.com
authors.forename: Richard V
authors.initials: RV
authors.lastname: Jones
authors.forename: Lajos
authors.initials: L
authors.lastname: Godorhazy
authors.forename: Norbert
authors.initials: N
authors.lastname: Varga
authors.forename: Daniel
authors.initials: D
authors.lastname: Szalay
authors.forename: Laszlo
authors.initials: L
authors.lastname: Urge
authors.forename: Ferenc
authors.initials: F
authors.lastname: Darvas
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006358:Hot Temperature; D006865:Hydrogenation; D015394:Molecular Structure; D011312:Pressure