title: Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration.
abstract: The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Whitwell
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Senjem
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
mesh_terms: D000367:Age Factors; D000368:Aged; D001284:Atrophy / Q000175:diagnosis*; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D003704:Dementia / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D009046:Motor Neurons / Q000378:metabolism / Q000473:pathology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016875:tau Proteins