title: Prenatal diagnosis in human immunodeficiency virus-infected women: a new screening program for chromosomal anomalies.
abstract: OBJECTIVE
  This study was undertaken to describe a new prenatal diagnosis program among human immunodeficiency virus (HIV)-infected women, and the perinatal outcome of this program's application over a more than 2-year period.
  
  
  METHODS
  From June 2000 to December 2003, all HIV-infected women who were booked into the antenatal clinic before 20 weeks were offered a screening for chromosomal anomalies, with midtrimester amniocentesis in the tests that were positive.
  
  
  RESULTS
  A total of 116 pregnancies (including 3 sets of twins) were seen: 96 women were offered and accepted screening for chromosomal anomalies. Thirteen pregnancies had a positive screening test and amniocentesis was performed in 10 at median 16.5 gestational weeks: a trisomy 21 and a monosomy X were diagnosed. No vertical transmissions were documented by age 6 months in the 6 liveborn infants who underwent amniocentesis.
  
  
  CONCLUSIONS
  A program of prenatal diagnosis for chromosomal anomalies appears to be effective when applied to HIV-infected women, although safety remains to be proven.
authors.affiliation: Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Barcelona, Spain.
authors.forename: Oriol
authors.initials: O
authors.lastname: Coll
authors.forename: Anna
authors.initials: A
authors.lastname: Suy
authors.forename: Sandra
authors.initials: S
authors.lastname: Hernandez
authors.forename: Sonia
authors.initials: S
authors.lastname: Pisa
authors.forename: Montserrat
authors.initials: M
authors.lastname: Lonca
authors.forename: Claire
authors.initials: C
authors.lastname: Thorne
authors.forename: Antoni
authors.initials: A
authors.lastname: Borrell
mesh_terms: D000328:Adult; D000649:Amniocentesis; D023241:Antiretroviral Therapy, Highly Active; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000175:diagnosis*; D002891:Chromosomes, Human, Pair 21; D041321:Chromosomes, Human, X; D005260:Female; D005820:Genetic Testing; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D009006:Monosomy / Q000175:diagnosis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D014314:Trisomy / Q000175:diagnosis