Quantum chemical analysis of alternative pathways for iron activation step for artemisinin, a new antimalarial drug.
Malaria is a mosquito-borne parasitic infection. It can be said that malaria is a very important tropical mosquito-borne infectious disease. The selection of antimalarial drugs depends on the species and the reported resistance pattern in each setting. Artemisinins are a new group of antimalarial drugs against the drug-resistant strains of malarial parasites. The mechanism of action of artemisinin compounds consists of two important steps: (a) activation and (b) alkylation. In the activation step by iron, there are two possible pathways for developing C-4 free radical: (a) 1.5 H-shift and (b) C-C cleavage. Here, the author performs a quantum chemical analysis of the activation reaction of artemisinin by the two alternative pathways. According to this study, the required energy for compound formation in C-C cleavage is more than that for C-O cleavage. It can be noted that the C-C cleavage pathway is less preferable, implying that the 1.5 H-shift should be the more common phenomenon.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. wviroj@yahoo.com
D000962:Antimalarials / Q000737:chemistry*; D037621:Artemisinins / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry*; D013816:Thermodynamics
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin; D007501:Iron