title: Biological studies of photoinducible phenol quaternary ammonium derivatives.
abstract: Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiao-Lian
authors.initials: XL
authors.lastname: Zhang
authors.forename: Linhong
authors.initials: L
authors.lastname: Weng
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Cao
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D005434:Flow Cytometry; D008027:Light; D010636:Phenols / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D003432:Cross-Linking Reagents; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D004247:DNA