Synthesis and cytotoxicity of new heterocyclic terpenylnaphthoquinones.
Several 2-arylamino-, 2-aryloxy- and 2-arylsulfanyl-6(7)-alkyl-1,4-naphthoquinones (NQ) have been prepared and further transformed into the corresponding heterocyclic-fused naphthoquinones by palladium (II)-catalyzed oxidative cyclization. The compounds synthesized have been evaluated against neoplastic cell lines. The extension of the polycyclic system clearly decreased the cytotoxic potency of the 2-substituted terpenylnaphthoquinones.
Miguel del Corral
José M
JM
Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007-Salamanca, Spain. jmmcs@usal.es
Castro
Maria Angeles
MA
Gordaliza
Marina
M
Martín
Maria Luz
ML
Gamito
Ana Maria
AM
Cuevas
Carmen
C
Feliciano
Arturo San
AS
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000970:Antineoplastic Agents; D009285:Naphthoquinones