title: Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy.
abstract: BACKGROUND
  Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease.
  
  
  OBJECTIVE
  To quantify the structural neuroanatomical differences between CBDS and PSP.
  
  
  METHODS
  A survey of neurologic deficits was conducted in all patients. Voxel-based morphometry was used to quantify structural neuroanatomical differences on magnetic resonance images in each subject group.
  
  
  METHODS
  University hospital dementia clinic.
  
  
  METHODS
  Fourteen patients who met clinical research criteria for CBD and 15 patients who met clinical research criteria for PSP, who were matched for severity of disease, age, and functional status, and 80 age-matched control subjects.
  
  
  METHODS
  Statistically significant differences in regional gray and white matter volume, after multiple comparisons correction, between groups of subjects.
  
  
  RESULTS
  The patients with CBDS displayed an asymmetric (left > right) pattern of brain atrophy that involved the bilateral premotor cortex, superior parietal lobules, and striatum. Progressive supranuclear palsy was associated with atrophy of the midbrain, pons, thalamus, and striatum, with minimal involvement of the frontal cortex. Midbrain structures were more atrophied in PSP than in CBD, whereas dorsal frontal and parietal cortices were more atrophied in CBD than in PSP. The degree of atrophy of the midbrain and pontine tegmentum and the left frontal eye field differentiated the 2 patient groups with 93% accuracy.
  
  
  CONCLUSIONS
  Distinct patterns of brain atrophy exist in CBDS and PSP that can be used to differentiate the 2 diseases. Assessments of brain atrophy in these disorders should be focused on cortical and brainstem ocular motor control areas.
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143-1207, USA. aboxer@memory.ucsf.edu
authors.forename: Adam L
authors.initials: AL
authors.lastname: Boxer
authors.forename: Michael D
authors.initials: MD
authors.lastname: Geschwind
authors.forename: Nataliya
authors.initials: N
authors.lastname: Belfor
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Gorno-Tempini
authors.forename: Guido F
authors.initials: GF
authors.lastname: Schauer
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Rosen
mesh_terms: D000368:Aged; D001284:Atrophy / Q000473:pathology; D001479:Basal Ganglia / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D003710:Demography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000473:pathology* / Q000503:physiopathology; D013494:Supranuclear Palsy, Progressive / Q000473:pathology* / Q000503:physiopathology