Markers of inflammation, vascular endothelial dysfunction, and age-related cataract.
OBJECTIVE
To examine the associations of systemic markers of inflammatory disease and vascular endothelial dysfunction with three types of age-related cataract.


METHODS
Cross-sectional analyses of data from a population-based sample of adults.


METHODS
Standardized protocols for blood collection, measurement of markers, administration of a questionnaire, and grading of lens photographs to determine cataract were used. Univariable and multivariable analyses were performed.


METHODS
Cohort in Beaver Dam, Wisconsin.


METHODS
A random sample of 396 persons who were > or =50 years of age.


METHODS
Prevalent age-related nuclear, cortical, and posterior subcapsular cataract.


RESULTS
Interleukin-6 and intracellular adhesion molecule-1 were associated significantly with prevalent nuclear cataract (odds ratio for each quartile, 1.45 and 2.17, respectively). Many of the associations of markers with cataract types were not linear. There were no significant associations between the markers and cortical or posterior subcapsular cataract.


CONCLUSIONS
Two serum markers of systemic inflammation and vascular endothelial dysfunction were associated with nuclear cataract.
Klein
Barbara E K
BE
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 N. Walnut Street, 460 WARF, Madison, WI 53726, USA. kleinb@epi.opth.wisc.edu
Klein
Ronald
R
Lee
Kristine E
KE
Knudtson
Michael D
MD
Tsai
Michael Y
MY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers / Q000097:blood*; D002386:Cataract / Q000097:blood* / Q000145:classification; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011795:Surveys and Questionnaires
D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1