Regulatory cells and human cancer.
While there is now little debate about the existence or relevance of regulatory populations of T cells to a variety of human diseases, including cancer, there is considerable debate about the ontogeny, phenotype, and mechanisms of action of given regulatory T cell populations. This review will limit itself to discussion to two distinct populations of CD4+ regulatory T cells: T cells co-expressing the CD25 receptor (Tregs), and type 1 regulatory (Tr1) T cells. Attention will be focused on the definition and role of these regulatory T cell populations in human cancers.
Baecher-Allan
Clare
C
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur NRB 641, Boston, MA 02115, USA. callan@rics.bwh.harvard.edu
Anderson
David E
DE
D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D015375:Receptors, Interleukin-2