Fluorine-18 DOPA PET imaging of paraganglioma syndrome.
A 12-year-old boy was admitted after recently having had a resection performed of an extraadrenal retroperitoneal paraganglioma and left adrenalectomy for pheochromocytoma. Despite these procedures, the blood pressure and urinary noradrenalin were elevated. Screening with fluorine-18 DOPA PET demonstrated increased tracer uptake in the right adrenal gland, in a second abdominal lesion, which was prevertebral, and 2 cervical hot spots near the carotid bifurcation, one on each side of the neck. The patient carries a mutation of the gene Succinate dehydrogenasis subunits D (SDHD) and is thus classified with the paraganglioma syndrome type 1.
Brink
Ingo
I
Department of Radiology, Albert-Ludwigs-University, Freiburg, Germany. ingo.brink@uniklinik-freiburg.de
Schaefer
Oliver
O
Walz
Martin
M
Neumann
Hartmut P H
HP
D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D002648:Child; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D006801:Humans; D008297:Male; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000235:genetics; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013385:Succinate Dehydrogenase / Q000235:genetics; D013577:Syndrome
D019275:Radiopharmaceuticals; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D013385:Succinate Dehydrogenase