A study of autologous melanocyte transfer in treatment of stable vitiligo.
BACKGROUND
Replenishing melanocytes selectively in vitiliginous macules by autologous melanocytes is a promising treatment. With expertise in culturing melanocytes, it has now become possible to treat larger recipient areas with smaller skin samples.


OBJECTIVE
To study the extent of repigmentation after autologous melanocyte transplantation in patients with stable vitiligo.


METHODS
The melanocytes were harvested as an autologous melanocyte rich cell suspension from a donor split thickness graft. Melanocyte culture was performed in selected cases where the melanocyte cell count was insufficient to meet the requirement of the recipient area. These cells were then transplanted to the recipient area that had been superficially dermabraded.


RESULTS
An excellent response was seen in 52.17% cases with the autologous melanocyte rich cell suspension (AMRCS) technique and in 50% with the melanocyte culture (MC) technique.


CONCLUSIONS
Autologous melanocyte transplantation can be an effective form of surgical treatment in stable but recalcitrant lesions of vitiligo.
Pandya
Vishvabhavan
V
Department of Dermatology, Civil Hospital and BJ Medical College, Ahmedabad, India. vbpandya@rediffmail.com
Parmar
Kirti S
KS
Shah
Bela J
BJ
Bilimoria
F E
FE
D000328:Adult; D002469:Cell Separation / Q000379:methods; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000637:transplantation*; D016038:Skin Transplantation; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014820:Vitiligo / Q000601:surgery*