title: Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population.
abstract: KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population.
authors.affiliation: Institute for Psychiatry, Clinical Center of Serbia, Belgrade, Serbia and Montenegro.
authors.forename: M
authors.initials: M
authors.lastname: Ivković
authors.forename: V
authors.initials: V
authors.lastname: Ranković
authors.forename: A
authors.initials: A
authors.lastname: Tarasjev
authors.forename: S
authors.initials: S
authors.lastname: Orolicki
authors.forename: A
authors.initials: A
authors.lastname: Damjanović
authors.forename: V R
authors.initials: VR
authors.lastname: Paunović
authors.forename: S
authors.initials: S
authors.lastname: Romac
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*; D051640:Small-Conductance Calcium-Activated Potassium Channels / Q000235:genetics*; D018709:Statistics, Nonparametric; D018911:Trinucleotide Repeats / Q000235:genetics*; D015022:Yugoslavia
chemical_list: C406328:KCNN3 protein, human; D051640:Small-Conductance Calcium-Activated Potassium Channels