Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.
Crane
Christine M
CM
Laboratorium für Organische Chemie, ETH Hönggerberg, HCI, 8093 Zürich, Switzerland.
Kaiser
Johannes
J
Ramsden
Nicola L
NL
Lauw
Susan
S
Rohdich
Felix
F
Eisenreich
Wolfgang
W
Hunter
William N
WN
Bacher
Adelbert
A
Diederich
François
F
D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology*; D001665:Binding Sites; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000494:pharmacology*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D019761:Phosphorus-Oxygen Lyases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013729:Terpenes / Q000378:metabolism*
D000962:Antimalarials; D004791:Enzyme Inhibitors; D029968:Escherichia coli Proteins; D005456:Fluorescent Dyes; D008024:Ligands; D013729:Terpenes; D019761:Phosphorus-Oxygen Lyases; C400181:ISPF protein, E coli