[Experimental study on anti-DHBV effect of yu gan capsules].
OBJECTIVE
To observe the antiviral effect of Yu Gan capsules against DHBV in ducks.


METHODS
50 Guangzhou brown spot ducks were used in this experiment. After the ducks were infected DHBV, they were divided into four groups at random (ACV 200 mg/kg group, Yu Gan capsules 6.5 g/kg group, Yu Gan capsules 3.25 g/kg group and virus control group) and Drugs were given by stomach once a day. Blood samples were taken from each duck and tested for DHBV-DNA's level. Researches left liver tissue were, sheared and used for optical analysis.


RESULTS
In Yu Gan capsules 6.5 g/kg group, DHBV-DNA's level in ducks' serum decreased on the 5th and 10th days after treatment and the 3th day after recession of treatment. There was a significant difference in the DHBV-DNA's level between the days after treatment and before treatment. there was also significant difference in the DHBV-DNA's level between Yu Gan capsules 6. 5 g/kg group and virus control group (P <0.01). Whereas, no inhibition effect was found in Yu Gan capsules 3.25 g/kg group.


CONCLUSIONS
Yu Gan capsules have functions on anti-DHBV in duck.
Tan
Xinghua
X
The Eighth People' s Hospital of Guangzhou, Guangzhou.
Zhang
Aimin
A
Yu
Weihua
W
Cen
Yuwen
Y
Zhang
Fengxue
F
D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002214:Capsules; D004279:DNA, Viral / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004372:Ducks; D015611:Hepatitis B Virus, Duck / Q000187:drug effects*; D006524:Hepatitis, Viral, Animal / Q000473:pathology*; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D002214:Capsules; D004279:DNA, Viral; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D000212:Acyclovir