Determinants of brain natriuretic peptide levels in patients with lone atrial fibrillation.
BACKGROUND
Although brain natriuretic peptide (BNP) is increasingly being used for screening and monitoring of congestive heart failure, its utility in patients with lone atrial fibrillation (AF) is unclear.


RESULTS
Plasma BNP levels were measured and comprehensive transthoracic echocardiography was performed in 96 subjects (47: sinus rhythm, 49: AF). Patients with structural heart disease were excluded. Potential determinants of BNP levels were identified by univariate and multivariate analyses. Individuals with AF had higher BNP levels than those with sinus rhythm (150 +/- 114 vs 49 +/- 61 pg/ml, p<0.001) The left atrial (LA) volume index (r=0.63, p<0.001), the pulmonary artery systolic pressure (r=0.45, p=0.006), and the early mitral inflow velocity (E)/mitral annular velocity (E') (r=0.36, p=0.04) were found to be independently correlated with BNP level. The correlations between BNP level and LA volume index (p=0.001) or E/E' (p=0.03) were unaltered when subjects with sinus rhythm were removed from the analysis.


CONCLUSIONS
BNP levels significantly correlated with LA volume index and E/E' in patients with lone AF, which indicates that the BNP level may reflect early left ventricular dysfunction and LA enlargement in this patient population.
Lee
Sang Hak
SH
Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea. shl1106@hallym.ac.kr
Jung
Jae-Hun
JH
Choi
Seung-Hyuk
SH
Lee
Namho
N
Park
Woo-Jung
WJ
Oh
Dong-Jin
DJ
Rhim
Chong-Yun
CY
Lee
Kwang-Hwak
KH
D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000000981:diagnostic imaging; D016279:Atrial Function, Left; D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012016:Reference Values; D012307:Risk Factors
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain