title: Stilbenoids of Kobresia nepalensis (Cyperaceae) exhibiting DNA topoisomerase II inhibition.
abstract: Resveratrol oligomers, nepalensinol A, B and C, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were established on the basis of chemical properties and spectroscopic evidence including 2D NMR spectroscopic analysis. Nepalensinol A, B and C showed a potent inhibitory effect on topoisomerase II -- stronger than etoposide (VP-16), a topoisomerase II inhibitor used as an anti-cancer drug. Nepalensinol B, in particular, exhibited the most potent activity with an IC(50) of 0.02 microg/ml.
authors.affiliation: Meiji Dairies Corporation, 2-10, Shinsuna 1-chome, Koto-Ku Tokyo 136-8908, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamada
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayashi
authors.forename: Shogo
authors.initials: S
authors.lastname: Ikeda
authors.forename: Takuji
authors.initials: T
authors.lastname: Hoshino
authors.forename: Ken
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Kimiko
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nozaki
mesh_terms: D000818:Animals; D016831:Crithidia fasciculata / Q000235:genetics; D029785:Cyperaceae / Q000737:chemistry* / Q000378:metabolism; D018105:DNA, Kinetoplast / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
chemical_list: D018105:DNA, Kinetoplast; D004791:Enzyme Inhibitors; D013267:Stilbenes; D059005:Topoisomerase II Inhibitors