Synthesis and characterization of Sn(IV) complexes of lower rim 1,3-diacid derivative of calix[4]arene and their protective effects on tissue oxidative stress and essential metal concentration in lead exposed male Wistar rats.
The two Sn(IV) complexes synthesized using calix[4]arene-1,3-di-acid derivative were characterized by analytical, (1)H, (13)C and (119)Sn NMR, matrix assisted laser desorption ionization mass, and (119)Sn Mossbauer techniques and found that the complexes are tetranuclear possessing structurally two different types of tin centers. These complexes were evaluated for their protective value against blood and tissue oxidative stress in lead exposed male albino rats of Wistar strain. The results suggest that the two tin complexes significantly protect changes in lead induced biochemical variables indicative of heme synthesis pathway and exhibit only moderate effect on tissue oxidative stress. The beneficial effects could be attributed mainly to the ability of Sn(IV) complexes in preventing absorption of lead to the target sites/tissues.
Ali
Amjad
A
Bioinorganic Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India.
Flora
Swaran J S
SJ
Saxena
Geetu
G
Kolehmainen
Erkki
E
Mahieu
Bernard
B
Rao
Chebrolu P
CP
D000818:Animals; D001792:Blood Platelets / Q000166:cytology; D047250:Calixarenes / Q000008:administration & dosage / Q000737:chemistry*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009947:Organotin Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D015204:Spectroscopy, Mossbauer; D014001:Tin / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry*
D009947:Organotin Compounds; D047250:Calixarenes; D007854:Lead; D014001:Tin