title: Chymotrypsin inhibitory triterpenoids from Silybum marianum.
abstract: Marianine, the new lanostane triterpene (1) and marianosides A (2) and B (3) have been isolated from the whole plant of Silybum marianum. Their structures were elucidated on the basis of extensive analysis of their one dimensional and two dimensional nuclear magnetic resonance (1D, 2D-NMR) spectral data. All inhibited chymotrypsin in a concentration-dependent manner.
authors.affiliation: International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmed
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Sadia
authors.initials: S
authors.lastname: Ferheen
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.lastname: Azhar-Ul-Haq
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002725:Chloroform; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D005960:Glucosides; D010936:Plant Extracts; D012997:Solvents; D014315:Triterpenes; D014361:Trypsin Inhibitors; C508591:marianine; C508593:marianoside A; C508595:marianoside B; D002725:Chloroform; D002918:Chymotrypsin