title: Acteoside of Callicarpa dichotoma attenuates scopolamine-induced memory impairments.
abstract: We previously reported that ten phenylethanoid glycosides including acteoside isolated from the leaves and twigs of Callicarpa dichotoma significantly attenuated glutamate-induced neurotoxicity. In the present study, we examined anti-amnesic activity of acteoside using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and Morris water maze tests. Acute oral treatment (single administration prior to scopolamine treatment) of mice with acteoside (1.0, 2.5 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in the passive avoidance test. It is interesting to note that prolonged oral daily treatment of mice with much lower amount (0.1 mg/kg body weight) of acteoside for 10 d reversed the scopolamine-induced memory deficits. In the Morris water maze, prolonged oral treatment with acteoside (prolonged daily administration of 1.0 mg/kg body weight for 10 d) significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. We suggest, therefore, that acteoside has anti-amnesic activity that may ultimately hold significant therapeutic value in alleviating certain memory impairment observed in Alzheimer's disease.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Kore, Seoul, Korea.
authors.forename: Ki Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Jeong
authors.forename: Heum-Sook
authors.initials: HS
authors.lastname: Lee
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D032408:Callicarpa / Q000737:chemistry*; D003071:Cognition / Q000187:drug effects; D005960:Glucosides / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D018727:Muscarinic Antagonists / Q000633:toxicity*; D010636:Phenols / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D059808:Polyphenols
chemical_list: D005960:Glucosides; D018727:Muscarinic Antagonists; D010636:Phenols; D012601:Scopolamine; C058956:acteoside; D059808:Polyphenols