Trivalent inactivated influenza vaccine safety in children: assessing the contribution of telephone encounters.
We assessed the contribution of telephone medical care encounters to surveillance of adverse events (AE) following trivalent influenza vaccination in children age 6 months to 17 years. We used retrospective, self-controlled, case-series analysis to estimate adverse event incidence rate ratios for post-vaccination risk intervals relative to 15-28 days prior to vaccination. We confirmed possible vaccination reactions by medical record abstraction. Detection of 10 of 20 elevated incidence rate ratios required telephone data. We conclude that telephone encounters substantially contribute to the detection of possible influenza vaccination reactions, primarily local injection site and systemic reactions.
Mullooly
J P
JP
Kaiser Permanente, Center for Health Research, 3800 N. Interstate Ave., Portland, OR 97227, USA. John.Mullooly@kpchr.org
Crane
B
B
Chun
C
C
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000009:adverse effects*; D012189:Retrospective Studies; D012449:Safety; D013689:Telephone; D014611:Vaccination / Q000009:adverse effects*; D015164:Vaccines, Inactivated / Q000009:adverse effects
D007252:Influenza Vaccines; D015164:Vaccines, Inactivated