title: Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese.
abstract: BACKGROUND
  Peroxisome proliferator-activated receptor gamma inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
  
  
  OBJECTIVE
  To study the association between peroxisome proliferator-activated receptor gamma gene polymorphism, Helicobacter pylori infection and gastric cancer in Chinese.
  
  
  METHODS
  One hundred and four consecutive patients with non-cardia gastric adenocarcinoma and 104 matched controls were examined. Peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The frequency of peroxisome proliferator-activated receptor gamma G (Ala12) allele was significantly higher among cancer patients (19.2%) than in control (8.7%; OR 2.5, 95% CI 1.1-5.8). While H. pylori infection was more prevalent in gastric cancer patients (OR 3.0; 95% CI 1.6-5.7), the combination of peroxisome proliferator-activated receptor gamma G allele and H. pylori infection further increased the risk of gastric cancer (OR 12.8, 95% CI 3.2-50.5). The presence of the Ala12 did not increase the risk of gastric cancer in H. pylori-negative subjects.
  
  
  CONCLUSIONS
  Our study suggests the potential association between peroxisome proliferator-activated receptor gamma polymorphism and H. pylori infection in the development of non-cardia gastric cancer.
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: S-Y
authors.initials: SY
authors.lastname: Liao
authors.forename: Z-R
authors.initials: ZR
authors.lastname: Zeng
authors.forename: W K
authors.initials: WK
authors.lastname: Leung
authors.forename: S-Z
authors.initials: SZ
authors.lastname: Zhou
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: J J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: P-J
authors.initials: PJ
authors.lastname: Hu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000382:microbiology; D005260:Female; D005838:Genotype; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology
chemical_list: D047495:PPAR gamma