title: Fibrodysplasia ossificans progressiva: case report.
abstract: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by postnatal progressive heterotopic ossification of the connective tissue and congenital malformation of the big toes. We report on a nine-year-old girl with clinical and radiological features of FOP. She was born with bilateral hallux valgus and at the age of nine presented an indurate mass in the left cervical region that was painful. A significant decreased range of motion in all levels of the spine and shoulder girdle was found. The radiographs showed heterotopic ossification in the thoracic region. The patient had two outbreaks of the disease ("flare-ups") that were treated with prednisone 2 mg/kg/day for four days. After the "flare-ups", she had a continuous therapy with a Cox-2 inhibitor (25 mg/day) and a leukotriene inhibitor, montelukast (10 mg/day).
authors.affiliation: Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, SP, Brazil. goncalvesnp@yahoo.com.br
authors.forename: Andre Leite
authors.initials: AL
authors.lastname: Gonçalves
authors.forename: Marcelo Rodrigues
authors.initials: MR
authors.lastname: Masruha
authors.forename: Carmelinda Correia
authors.initials: CC
authors.lastname: de Campos
authors.forename: Patricia Longo Ribeiro
authors.initials: PL
authors.lastname: Delai
authors.forename: Luiz Celso Pereira
authors.initials: LC
authors.lastname: Vilanova
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D002648:Child; D003521:Cyclopropanes; D005260:Female; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D009221:Myositis Ossificans / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011804:Quinolines / Q000627:therapeutic use*; D013440:Sulfides; D014057:Tomography, X-Ray Computed
chemical_list: D000085:Acetates; D000305:Adrenal Cortex Hormones; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast