title: Therapeutic strategies for combined-modality therapy of locally advanced non-small-cell lung cancer: rationale for consolidation docetaxel therapy.
abstract: Currently, there is no accepted standard of care for locally advanced and surgically unresectable non-small-cell lung cancer. Typically, treatment for patients with good performance status consists of a combination of chemotherapy and thoracic radiation therapy (RT), but the integration of these modalities and the respective dose schedules vary considerably. Herein, we review the rationale for a treatment paradigm employing consolidation docetaxel therapy after concurrent chemotherapy/RT and the results of recent clinical trials using this approach.
authors.affiliation: Department of Hematology/Oncology, University of California Davis Cancer Center, Sacramento, CA 95817-2229, USA. david.gandara@ucdmc.ucdavis.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Gandara
authors.forename: Eric
authors.initials: E
authors.lastname: Vallières
authors.forename: Laurie E
authors.initials: LE
authors.lastname: Gaspar
authors.forename: Karen
authors.initials: K
authors.lastname: Kelly
authors.forename: Kathy S
authors.initials: KS
authors.lastname: Albain
authors.forename: Roy S
authors.initials: RS
authors.lastname: Herbst
authors.forename: Primo N
authors.initials: PN
authors.lastname: Lara
authors.forename: Philip
authors.initials: P
authors.lastname: Mack
authors.forename: Paul H
authors.initials: PH
authors.lastname: Gumerlock
authors.forename: John J
authors.initials: JJ
authors.lastname: Crowley
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D000077143:Docetaxel; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel