Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract.
The aqueous extract of the tuber of Smilax china L., popularly known in China as "jin gang ten", was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively. The aqueous extract in the dose of 1000 mg/kg (i.g.) had a significant anti-nociceptive and anti-inflammatory effect compared to physiological saline. The anti-inflammatory effects are similar to acetylsalicylic acid (200 mg/kg, i.g.). We also evaluated the aqueous extract for the inhibition of prostaglandin production (for COX-2 inhibitions) in lipopolysaccharide (LPS)-induced mouse macrophage cells. The result showed that both COX-2 activity and COX expression were inhibited by the extract. These active extracts suppressing activities warranted further studies of active principles and development of new anti-inflammatory and analgesic agents. Studies to determine correlation between chemical composition and pharmacological activity are underway.
Shu
Xiao-Shun
XS
Department of Biology, ChangSha University of Science & Technology, ChangSha 410076, Hunan, PR China. sxs732@sohu.com
Gao
Zhong-Hong
ZH
Yang
Xiang-Liang
XL
D019342:Acetic Acid; D000418:Albumins; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D051546:Cyclooxygenase 2 / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D032281:Smilax; D013997:Time Factors
D000418:Albumins; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D004365:Drugs, Chinese Herbal; D051546:Cyclooxygenase 2; D015232:Dinoprostone; D019342:Acetic Acid