title: 5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis.
abstract: Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.
authors.affiliation: The Queensland Institute of Medical Research and ACITHN, P.O. Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Jacqui.Upcroft@qimr.edu.au
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Upcroft
authors.forename: Linda A
authors.initials: LA
authors.lastname: Dunn
authors.forename: Janelle M
authors.initials: JM
authors.lastname: Wright
authors.forename: Kamel
authors.initials: K
authors.lastname: Benakli
authors.forename: Peter
authors.initials: P
authors.lastname: Upcroft
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004351:Drug Resistance; D016829:Giardia lamblia / Q000187:drug effects*; D008795:Metronidazole / Q000494:pharmacology*; D008970:Molecular Weight; D009593:Nitroimidazoles / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D009593:Nitroimidazoles; D008795:Metronidazole