title: Double primary lung carcinoma consisting of large cell neuroendocrine carcinoma and squamous cell carcinoma: report of a case.
abstract: We report a rare case of double primary lung carcinoma including large cell neuroendocrine carcinoma (LCNEC). A 67-year-old man underwent an annual medical checkup in 2000, pulmonary carcinoma was strongly suspected by sputum cytology and radiological images. Preoperative diagnosis was double primary lung carcinoma with a squamous cell carcinoma in the right lower lobe and non-small cell carcinoma in the right upper lobe. The histological carcinoma type in the right upper lobe could not be determined preoperatively. The patient underwent a right lower lobectomy and wedge resection of the right upper lobe. Histologically, the tumor in the right upper lobe was LCNEC and the tumor in the right lower lobe was a moderately differentiated squamous cell carcinoma. The patient had right supraclavicular lymph node metastases of LCNEC and died of multiple pulmonary metastases 10 months after the operation.
authors.affiliation: Department of Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Yamada
authors.forename: Akira
authors.initials: A
authors.lastname: Iyoda
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
authors.forename: Teruaki
authors.initials: T
authors.lastname: Mizobuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Baba
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ohwada
authors.forename: Takehiko
authors.initials: T
authors.lastname: Fujisawa
mesh_terms: D000368:Aged; D018287:Carcinoma, Large Cell / Q000473:pathology* / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D011013:Pneumonectomy