title: [Safety and effectiveness of opiate antagonist detoxification under general anesthesia].
abstract: OBJECTIVE
  To evaluate safety and effectiveness of opiate antagonist detoxification under general anesthesia according to available prospective and retrospective data.
  
  
  METHODS
  We analyzed all detoxification cases that were performed in Vilnius University Emergency Hospital in the period of 2002-2005. Data of 65 patients from prospective, randomized, double-blind, placebo-controlled study and 21 retrospective cases were included in the study.
  
  
  RESULTS
  Full opiate receptor blockade was achieved in 85 cases (98.84%). No complications related to detoxification procedure or general anesthesia were recorded. Differences in procedure protocols and possible implications for clinical practice are discussed.
  
  
  CONCLUSIONS
  The protocol of the prospective study may be recommended as a safe and effective detoxification method.
authors.affiliation: Clinic of Anesthesiology and Intensive Care, Vilnius University, Siltnamiu 29, 04130 Vilnius, Lithuania.
authors.forename: Juozas
authors.initials: J
authors.lastname: Ivaskevicius
authors.forename: Tomas
authors.initials: T
authors.lastname: Jovaisa
authors.forename: Giedrius
authors.initials: G
authors.lastname: Laurinenas
authors.forename: Saulius
authors.initials: S
authors.lastname: Vosylius
authors.forename: Jūrate
authors.initials: J
authors.lastname: Sipylaite
authors.forename: Robertas
authors.initials: R
authors.lastname: Badaras
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D000931:Antidotes; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D010919:Placebos; D011446:Prospective Studies; D011957:Receptors, Opioid / Q000187:drug effects; D012449:Safety; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000931:Antidotes; D009292:Narcotic Antagonists; D010919:Placebos; D011957:Receptors, Opioid; D009271:Naltrexone