Role of complement and other innate immune mechanisms in the removal of apoptotic cells.
The complement system is regarded as an ancient host defense mechanism that helps to promote phagocytosis and/or killing of foreign microorganisms. Less well known is the facilitatory role that complement and other closely related molecules of the innate immune system play in the removal of dying cells. In this chapter, we review the complement system and the mechanisms of complement activation that include natural antibodies and acute phase proteins. The effects of spontaneous and genetically engineered mutations on function of these proteins and their relationship to autoimmune diseases such as lupus are discussed. We also review the known function of non-complement receptors and their roles in recognition and removal of dying cells in normal cellular homeostasis and in inflammation.
Ogden
Carol Anne
CA
Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA 98195-6428, USA.
Elkon
Keith B
KB
D000210:Acute-Phase Reaction; D000818:Animals; D000906:Antibodies / Q000276:immunology; D015703:Antigens, CD / Q000502:physiology; D017209:Apoptosis; D037282:Calreticulin / Q000502:physiology; D015922:Complement C1q / Q000502:physiology; D003176:Complement C3 / Q000502:physiology; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D018950:Lipopolysaccharide Receptors / Q000502:physiology; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D010586:Phagocytes / Q000502:physiology; D010587:Phagocytosis; D010718:Phosphatidylserines / Q000502:physiology
D000906:Antibodies; D015703:Antigens, CD; D037282:Calreticulin; D003176:Complement C3; C475476:LRP1 protein, human; D018950:Lipopolysaccharide Receptors; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D010718:Phosphatidylserines; D015922:Complement C1q; D003165:Complement System Proteins