title: Results of penetrating keratoplasty for visual rehabilitation after Acanthamoeba keratitis.
abstract: OBJECTIVE
  To assess the results of penetrating keratoplasty in quiet eyes after resolution of Acanthamoeba keratitis.
  
  
  METHODS
  A retrospective interventional case series.
  
  
  METHODS
  Penetrating keratoplasty was undertaken in 13 eyes of 13 patients with an average age of 29 +/- 13 years and a history of Acanthamoeba keratitis that was diagnosed by culture and/or confocal microscopy between January 1995 and September 2004. All eyes were observed for at least 3 months (average, 5 months) after the discontinuation of antiamebic therapy that had been administered for at least 4.5 months. In vivo confocal microscopy was used to ensure that no residual amoeba were present before the operation. Two keratoplasties were combined with a valve insertion; five keratoplasties were combined with cataract extraction, and one keratoplasty was preceded by a ciliary laser ablation.
  
  
  RESULTS
  Postoperative best-corrected visual acuity ranged from 20/40 to 20/15, with the exception of one eye with advanced glaucoma that did not improve from a preoperative vision of light perception. No eye experienced rejection or amoebic recurrences, and 12 grafts remained clear throughout the follow-up period (8 months to 9 years; median, 23 months). One graft failed at 4 months because of uncontrolled glaucoma. The eye was regrafted, and the graft remained clear during the 28 months of follow-up evaluation. Two eyes with preoperatively diagnosed glaucoma needed subsequent surgery to control their intraocular pressure.
  
  
  CONCLUSIONS
  Penetrating keratoplasty for visual restoration after Acanthamoeba keratitis appears to have an excellent long-term prognosis, provided amoebic infection has resolved and concurrent glaucoma is controlled.
authors.affiliation: Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA.
authors.forename: Shady T
authors.initials: ST
authors.lastname: Awwad
authors.forename: Dipak N
authors.initials: DN
authors.lastname: Parmar
authors.forename: Michelle
authors.initials: M
authors.lastname: Heilman
authors.forename: R Wayne
authors.initials: RW
authors.lastname: Bowman
authors.forename: James P
authors.initials: JP
authors.lastname: McCulley
authors.forename: H Dwight
authors.initials: HD
authors.lastname: Cavanagh
mesh_terms: D000048:Acanthamoeba / Q000302:isolation & purification; D015823:Acanthamoeba Keratitis / Q000469:parasitology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000818:Animals; D003315:Cornea / Q000469:parasitology / Q000601:surgery; D005260:Female; D006084:Graft Rejection; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D014786:Vision Disorders / Q000469:parasitology / Q000534:rehabilitation*; D014792:Visual Acuity