title: Study of GM immunoglobulin allotypic system in Berbers and Arabs from Morocco.
abstract: The GM immunoglobulin allotype polymorphism was investigated in four Moroccan populations: three Berber groups from Khenifra (Middle Atlas), Amizmiz (High Atlas), and Bouhria (Beni Snassen) and one Arabic-speaking sample from the Doukkala area (Abda, Chaouia, Doukkali, and Tadla districts in south-central Morocco). In order to characterize the genetic relationships between the populations, our results were compared with those obtained for other North African groups (from Morocco, Algeria, Tunisia, and Niger) and for Middle-East Africans, sub-Saharans, and Southwest Europeans. Based on GM haplotype frequencies, Factorial Correspondence Analyses, F(ST) significance testing, and hierarchical analyses of variance were performed. Our results reveal that Moroccan populations have heterogeneous GM profiles with high frequencies of GM haplotypes in Europeans (from 76% for Doukkala to 88% for Bouhria) and relatively high frequencies of GM haplotypes in sub-Saharans (from 11% for Bouhria to 23% for Amizmiz). The genetic diversity observed among Moroccans is not significantly correlated with either geographic or linguistic differentiation. In spite of their cultural and historical differentiation, we did not discover any significant genetic differences between Berbers and Arabic-speakers from Morocco. However, when large geographical areas are considered, our population samples are integrated in the North African GM variation, significantly distant from sub-Saharan groups but with a close relationship with Southwest European populations.
authors.affiliation: Centre d'Anthropologie, UMR 8555, CNRS, Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Coudray
authors.forename: E
authors.initials: E
authors.lastname: Guitard
authors.forename: M
authors.initials: M
authors.lastname: Kandil
authors.forename: N
authors.initials: N
authors.lastname: Harich
authors.forename: M
authors.initials: M
authors.lastname: Melhaoui
authors.forename: A
authors.initials: A
authors.lastname: Baali
authors.forename: A
authors.initials: A
authors.lastname: Sevin
authors.forename: P
authors.initials: P
authors.lastname: Moral
authors.forename: J M
authors.initials: JM
authors.lastname: Dugoujon
mesh_terms: D000704:Analysis of Variance; D018912:Arabs / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D008297:Male; D009018:Morocco; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D007129:Immunoglobulin Gm Allotypes