[Morphological changes of rat ovaries after their monopolar coagulation and ascovertin correction].
Using the methods of light and electron microscopy, morpho-functional changes of the ovaries of albino rats after their monopolar coagulation were studied. Electrocoagulation was shown to cause hemodynamic changes in a perifocal area and short-term stimulation of follicular growth, but starting already at postoperational day 3, their atresia was increased, while by day 30 a significant reduction in number of both primordial and growing follicles, as well as of corpora lutea, was found. Ultrastructural changes of oocytes in primary and secondary follicles outside the coagulation zone were demonstrated at early stages and included the reduction of porous plate, cortical and yolk granule numbers, and the increase in numbers of lysosomes and multivesicular bodies. Ascovertin, due to its antioxidant properties and by improving hemorheological parameters, exerts a protective action on ovarian generative apparatus and the state of microcirculation in the organ.
Logvinov
S V
SV
Tikhonovskaia
O A
OA
Plotnikov
M B
MB
Bukharina
I Iu
IIu
Petrov
I A
IA
Okorokov
A O
AO
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004338:Drug Combinations; D004564:Electrocoagulation; D005260:Female; D044948:Flavonols / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012038:Regeneration / Q000187:drug effects*
D000975:Antioxidants; D004338:Drug Combinations; D044948:Flavonols; D011794:Quercetin; C003377:taxifolin; D001205:Ascorbic Acid