title: Small cell carcinoma of the larynx treated with irinotecan and cisplatin.
abstract: We report a case of advanced small cell carcinoma in the larynx, which was treated with Irinotecan hydrochloride (CPT-11) chemotherapy. The patient was free of disease for 4 years after treatment. Several chemotherapeutic agents for small cell carcinoma have been proposed; however, median survival time has been miserable, especially in advanced cases. For the cure of the aggressive lethal behavior of this disease, chemotherapy with CPT-11 might be effective to improve median survival of patients with small cell carcinomas of the larynx.
authors.affiliation: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. michsone@med.nagoya-u.ac.jp
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Ikue
authors.initials: I
authors.lastname: Uchida
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Tominaga
authors.forename: Saiko
authors.initials: S
authors.lastname: Sugiura
authors.forename: Testuro
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D002945:Cisplatin / Q000627:therapeutic use*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D002945:Cisplatin