title: Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico.
abstract: Matrix gamma-carboxyglutamic acid protein (MGP) genotypes (G-7A and T-138C) were determined in 266 individuals from three Mexican populations. Mexicans showed increased frequencies of the G-7A G allele and the G7-A GG genotype compared to Europeans. For the T-138C genotype, we found differences among the Mexicans. This study could help to define the significance of MGP polymorphisms as genetic markers in Amerindian populations.
authors.affiliation: Department of Physiology and Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiología "Ignacio Chávez," Juan Badiano No. 1, Tlalpan 14080, Mexico City, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Hernández-Pacheco
authors.forename: Luis Enrique
authors.initials: LE
authors.lastname: Murguía
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Pérez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.forename: Nadia
authors.initials: N
authors.lastname: Pérez-Vielma
authors.forename: Nancy
authors.initials: N
authors.lastname: Martínez-Rodríguez
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D002135:Calcium-Binding Proteins / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D044465:White People / Q000235:genetics*; D000097568:Matrix Gla Protein
chemical_list: D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D005819:Genetic Markers; D000097568:Matrix Gla Protein