title: Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease.
abstract: Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University.
authors.forename: Quan-Zhong
authors.initials: QZ
authors.lastname: Sun
authors.forename: Dao-Feng
authors.initials: DF
authors.lastname: Chen
authors.forename: Pei-Lan
authors.initials: PL
authors.lastname: Ding
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Ma
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kakuda
authors.forename: Norio
authors.initials: N
authors.lastname: Nakamura
authors.forename: Masao
authors.initials: M
authors.lastname: Hattori
mesh_terms: D002855:Chromatography, Thin Layer; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D017320:HIV Protease Inhibitors; D017705:Lignans; C508620:longipedunin A; C508621:longipedunin B; C508622:longipedunin C