title: First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early-onset Alzheimer's disease: comparison with senile dementia of Alzheimer's type.
abstract: We evaluated dementia symptoms to clarify the character of dementia with Alzheimer's disease (AD) observed in the oldest old patients and that of dementia with early-onset AD. Subjects were consecutive AD inpatients admitted for the first time at age of 90 years and over because of behavioral symptoms (demented nonagenarian group: D90G; n=18) and those with 24 consecutive inpatients with AD with early-onset (EOG). The Gottfries, Brane and Steen's scale and the Dementia Behavior Disturbance scale were used to evaluate the symptoms and troublesome behaviors. The scores of these scales in D90G and in EOG were compared with those of 26 sex distribution-, severity of dementia-, and disease duration-matched inpatients with AD with late-onset (LOG). Compared with LOG, wakefulness was more impaired and waking up at night was more frequent in D90G, while memory, orientation and inappropriate behaviors were more severe in EOG. These results suggest that the clinical features of dementia in EOG were quantitatively different from those of LOG. In contrast, the clinical feature of dementia of D90G were sleep-wake pattern disturbance and were qualitatively different from those of LOG.
authors.affiliation: Department of Psychiatry, Showa University Fujigaoka Hospital, Kanagawa, Japan. kojihori@showa-university-fujigaoka.gr.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Hori
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Oda
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Asaoka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Shoichi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Reiko
authors.initials: R
authors.lastname: Oyamada
authors.forename: Itaru
authors.initials: I
authors.lastname: Tominaga
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over / Q000523:psychology*; D000544:Alzheimer Disease / Q000523:psychology*; D001519:Behavior; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009949:Orientation; D011569:Psychiatric Status Rating Scales; D014851:Wakefulness / Q000502:physiology