title: [Comparative characteristic of structural-functional changes of the spleen in the offspring of female rats with chronic liver pathology of various etiology].
abstract: The aim of the study was a comparative analysis of structural-functional changes of the spleen in the offspring of female rats with chronic liver pathology of various genesis. In adult female Wistar rats various forms of liver lesions were modeled: toxic, autoimmune, cholestatic. The spleen of the offspring of the experimental animals with chronic liver disease was studied at different time points of postnatal ontogenesis. The increased numbers of Ig-producing cells and splenic karyocytes were detected in association with an increased surface area of the section, occupied by lymphoid nodules. Activation of proliferation and differentiation of B-lymphocytes was found together with an increase of the surface area of the section, occupied by B-dependent zones, indicating the increased intensity of humoral immunity in the offspring of female rats with chronic pathology of hepatobiliary system of various genesis.
authors.forename: G V
authors.initials: GV
authors.lastname: Briukhin
authors.forename: G I
authors.initials: GI
authors.lastname: Mikhaĭlova
authors.forename: E N
authors.initials: EN
authors.lastname: Pashnina
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D008107:Liver Diseases / Q000276:immunology* / Q000473:pathology*; D008213:Lymphocyte Activation; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000254:growth & development / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G