title: Chemokines as markers for parasite-induced inflammation and tumors.
abstract: Chemokines are a group of small secreted proteins (8-10 kDa) produced and released by a wide variety of cell types. They were originally described as mediators of leukocyte recruitment, which is essential in acute and chronic inflammation. They also play a critical role in many pathophysiological processes such as allergic responses, infections and autoimmune diseases, tumor growth and hematopoietic development. This review introduces the three supergene families of chemokines (CXC, CC and C) with emphasis on their important role in different states in humans and in animal models with parasitic diseases. The concentration of transcription and translation of the cytokines and chemokines in the parasitic diseases may be an important marker for evaluation of the inflammatory state.
authors.affiliation: Department of Internal Medicine, Georgios Gennimatas Hospital, Thessaloniki.
authors.forename: C
authors.initials: C
authors.lastname: Trakatelli
authors.forename: S
authors.initials: S
authors.lastname: Frydas
authors.forename: M
authors.initials: M
authors.lastname: Hatzistilianou
authors.forename: E
authors.initials: E
authors.lastname: Papadopoulos
authors.forename: I
authors.initials: I
authors.lastname: Simeonidou
authors.forename: A
authors.initials: A
authors.lastname: Founta
authors.forename: D
authors.initials: D
authors.lastname: Paludi
authors.forename: C
authors.initials: C
authors.lastname: Petrarca
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: N
authors.initials: N
authors.lastname: Papaioannou
authors.forename: V
authors.initials: V
authors.lastname: Salini
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: D
authors.initials: D
authors.lastname: Kempuraj
authors.forename: J
authors.initials: J
authors.lastname: Vecchiet
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D018925:Chemokines / Q000097:blood* / Q000145:classification; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000469:parasitology; D009369:Neoplasms / Q000097:blood*; D010272:Parasitic Diseases / Q000097:blood* / Q000469:parasitology*
chemical_list: D015415:Biomarkers; D018925:Chemokines