Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity.
Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.
Tanabe
Takamasa
T
Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Yokohama 223-8522, Japan.
Ogamino
Takahisa
T
Shimizu
Yoshifumi
Y
Imoto
Masaya
M
Nishiyama
Shigeru
S
D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D047188:Chalcones; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D013055:Spectrophotometry, Infrared
D047188:Chalcones; C433608:verbenachalcone; D002599:Chalcone; D020932:Nerve Growth Factor