title: Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei.
abstract: A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.
authors.affiliation: Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yushan
authors.initials: Y
authors.lastname: Li
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Watanabe
authors.forename: Yasukatsu
authors.initials: Y
authors.lastname: Oshima
authors.forename: Tohru
authors.initials: T
authors.lastname: Yamakuni
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
mesh_terms: D000818:Animals; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009414:Nerve Growth Factors / Q000737:chemistry*; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014632:Valerian / Q000737:chemistry*
chemical_list: D039823:Iridoids; D009414:Nerve Growth Factors; D012717:Sesquiterpenes