Amino acid changes during successful pregnancy in a case of lysinuric protein insufficiency.
Lysinuric protein insufficiency (LPI) is a rare autosomal recessive disorder, and pregnancy in patients with this condition has been considered risky. We, however, observed a relatively favorable course of pregnancy in a woman with LPI, and even amelioration of symptoms during pregnancy. We believe that this unique observation is not only important for patients with LPI who are facing a choice of child-bearing, but is also of interest to obstetricians and researchers of amino acid metabolism.
Osada
Hisao
H
Department of Obstetrics and Gynecology, Chiba University Hospital, Division of Maternal-Fetal Medicine, Chiba, Japan.
Seki
Katsuyoshi
K
D000328:Adult; D000592:Amino Acid Metabolism, Inborn Errors / Q000178:diet therapy / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism; D001692:Biological Transport; D015415:Biomarkers / Q000097:blood; D018753:Diet, Protein-Restricted; D005260:Female; D006801:Humans; D022124:Hyperammonemia / Q000178:diet therapy / Q000378:metabolism; D008239:Lysine / Q000378:metabolism*; D009952:Ornithine / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy / Q000378:metabolism
D015415:Biomarkers; D001120:Arginine; D009952:Ornithine; D008239:Lysine