title: Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.
abstract: The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.
authors.affiliation: Laboratory of Medical Oncology, Department of Oncological Sciences, IRCC Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Turin, Italy. wanda.piacibello@ircc.it
authors.forename: Wanda
authors.initials: W
authors.lastname: Piacibello
authors.forename: Loretta
authors.initials: L
authors.lastname: Gammaitoni
authors.forename: Ymera
authors.initials: Y
authors.lastname: Pignochino
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000276:immunology; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000235:genetics / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D019098:Telomerase / Q000502:physiology; D016615:Telomere / Q000502:physiology
chemical_list: D018952:Antigens, CD34; D019098:Telomerase