[Hypolipidemic therapy in special situations: hypothyroidism and liver disease].
Hypothyroidism is common in the elderly, especially among women. It should be suspected in the presence of classic signals and symptoms, and can be detected by an elevation of serum thyroid stimulating hormone (TSH). Lipid abnormalities in the presence of subclinical hypothyroidism are of minor importance. However, the importance of specific treatment (hormone replacement) increases with the magnitude of thyroid disturbance. Some hypolipidemic agents can aggravate prior liver disease, however, recent studies have shown that statins might be useful in the presence of steatohepatitis. Some associations of hypolipidemic drugs can increase liver enzymes, and careful monitoring is recommended.
Cesena
Fernando H Y
FH
Unidade Clínica de Aterosclerose, Instituto do Coração, HCFMUSP.
Xavier
Hermes Toros
HT
Luz
Protásio L da
PL
D000367:Age Factors; D001384:Azetidines / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D002994:Clofibrate / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D004347:Drug Interactions; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy; D000069438:Ezetimibe; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D007037:Hypothyroidism / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D012737:Sex Factors; D013972:Thyrotropin / Q000097:blood
D001384:Azetidines; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013972:Thyrotropin; D000069438:Ezetimibe; D002994:Clofibrate