Long-term results for liver transplantation from non-heart-beating donors maintained with chest and abdominal compression-decompression.
BACKGROUND
The aim of this study was to evaluate long-term results after liver transplantation from non-heart-beating donors (NHBD) using the method of chest and abdominal compression-decompression to maintain donors.


METHODS
From December 1995 to November 2004, 10 NHBD were identified and maintained by means of the method of chest and abdominal compression-decompression until family and judicial permission were granted. Nine donors were Maastricht type II and one was type IV.


RESULTS
The mean age of donors was 40.5 years and the mean time under cardiopulmonary resuscitation (CPR) was 80 minutes. Orthotopic liver transplantation (OLT) was performed using these 10 liver grafts after a mean cold ischemia time of 561.5 minutes. All patients developed good posttransplant function, except for one patient who presented with primary nonfunction corrected with retransplantation. This complication was directly related to a long CPR time (P < .01). After a mean follow-up of 57 months, only one patient died from a hepatitis C virus (HCV) recurrence. The rest of the patients have maintained good graft function over time.


CONCLUSIONS
NHBD maintained with the method of chest and abdominal compression-decompression are a valid choice to increase the donor pool. Liver transplantation using these grafts has proven good long-term results, comparable to their heart-beating counterparts.
Quintela
J
J
Transplant Unit, Juan Canalejo University Hospital, La Coruña, Spain.
Gala
B
B
Baamonde
I
I
Fernández
C
C
Aguirrezabalaga
J
J
Otero
A
A
Suárez
F
F
Fernández
A
A
Gomez
M
M
D000328:Adult; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D003664:Decompression / Q000379:methods*; D006323:Heart Arrest; D006801:Humans; D008099:Liver; D016031:Liver Transplantation / Q000379:methods / Q000502:physiology*; D008150:Lower Body Negative Pressure / Q000379:methods*; D018579:Patient Selection; D013909:Thorax; D014019:Tissue Donors; D016896:Treatment Outcome