Abdominal positron-emission tomography lesions with increased standardized uptake values correlate with intraoperative findings.
BACKGROUND
The reporting of standardized uptake value (SUV) on fluoro-2-deoxy-D-glucose positron-emission tomography (FDG-PET) in colorectal cancer is becoming common practice, but its clinical utility remains to be determined. This study was designed to compare FDG-PET uptake as measured by SUV with operative findings.


METHODS
A colorectal cancer database was queried to identify patients who underwent FDG-PET scans with reported SUVs followed by exploratory laparotomy within 3 months and compare these results to determine FDG-PET sensitivity.


RESULTS
Of 46 patients, 16 (34.8%) were found to be have increased extent of disease intraoperatively than seen on FDG-PET scan. This patient population had a statistically significant decreased mean maximal SUV than the patients whose FDG-PET scan equaled intraoperative findings (P < .025).


CONCLUSIONS
This initial study indicates patients with potentially resectable disease by PET scan but decreased FDG uptake should undergo laparoscopic evaluation before performing laparotomy.
Horst
Sara
S
Division of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Kocak
Ergun
E
Young
Donn
D
Mantil
Joseph
J
Martin
Edward W
EW
D000005:Abdomen / Q000000981:diagnostic imaging / Q000601:surgery; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18