title: Osteonecrosis of the jaws and bisphosphonates. Report of three cases.
abstract: Bisphosphonates are recently acquiring increasing relevance in the treatment of several diseases. In line with the increased use of these compounds, cases of mandibular osteonecrosis, and to a lesser extent, maxillary osteonecrosis, are being reported. This necrosis is difficult to treat in patients who usually have a previously limited quality of life. A surgical performance carried out by oral and maxillofacial surgeons, stomatologists and odontologists might lead to bone exposure. A treatment based on conservation and as harmless as possible seems to be the most advisable way of acting with these patients in order to minimize the incidence and treat the complications, once the lesions have been ascertained. We report three cases treated in our service of osteonecrosis of the jaws after exodontics. This side effect should be remembered before starting any surgical treatment in these patients.
authors.affiliation: Servicio de Cirugía Oral y Maxilofacial, Hospital Virgen del Camino, Pamplona, Navarra. dapazu@hotmail.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Pastor-Zuazaga
authors.forename: Joaquín
authors.initials: J
authors.lastname: Garatea-Crelgo
authors.forename: Raúl
authors.initials: R
authors.lastname: Martino-Gorbea
authors.forename: Amaya
authors.initials: A
authors.lastname: Etayo-Pérez
authors.forename: Cristina
authors.initials: C
authors.lastname: Sebastián-López
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy; D007093:Imidazoles / Q000009:adverse effects; D007571:Jaw Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000532:radiotherapy / Q000628:therapy; D010020:Osteonecrosis / Q000139:chemically induced*; D000077268:Pamidronate; D014081:Tooth Extraction / Q000009:adverse effects; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000077268:Pamidronate