title: Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum.
abstract: A crystal structure is reported of the peptide Ac-Ala-Asn-Pro-Asn-Ala-NH2, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I beta-turn, which is stabilized by hydrogen bonding between the CO of Asn2 and the NH of Ala5 as well as between the O(delta) of Asn2 and the NH of Asn4.
authors.affiliation: Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
authors.forename: Arin
authors.initials: A
authors.lastname: Ghasparian
authors.forename: Kerstin
authors.initials: K
authors.lastname: Moehle
authors.forename: Anthony
authors.initials: A
authors.lastname: Linden
authors.forename: John A
authors.initials: JA
authors.lastname: Robinson
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000737:chemistry*; D015800:Protozoan Proteins / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009842:Oligopeptides; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan