Soy diet worsens heart disease in mice.
We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the alpha-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen synthase kinase 3beta (GSK3beta), and caspase-3 activation.
Stauffer
Brian L
BL
Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado, USA.
Konhilas
John P
JP
Luczak
Elizabeth D
ED
Leinwand
Leslie A
LA
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D006321:Heart / Q000033:anatomy & histology / Q000187:drug effects; D006331:Heart Diseases / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics; D009929:Organ Size; D012727:Sex Characteristics; D030262:Soybean Proteins / Q000009:adverse effects*
D030262:Soybean Proteins; D018995:Myosin Heavy Chains