The evolutionary relationship of the domain architectures in the RhoGEF-containing proteins.
Domain insertions and deletions lead to variations in the domain architectures of the proteins from their common ancestor. In this work, we investigated four groups of the RhoGEF-containing proteins from different organisms with domain architectures RhoGEF-PH-SH3, SH3-RhoGEF-PH, RhoGEF-PH, and SH3-RhoGEF defined in the Pfam database. The phylogenetic trees were constructed using each individual domain and/or the combinations of all the domains. The phylogenetic analysis suggests that RhoGEF-PH-SH3 and SH3-RhoGEF-PH might have evolved from RhoGEF-PH through the insertion of SH3 independently, while SH3-RhoGEF of proteins in fruit fly might have evolved from SH3-RhoGEF-PH by the degeneration of PH domain.
Sun
Qing Lan
QL
The Key Laboratory of the Ministry of Education for Biodiversity Science and Ecological Engineering, College of Life Sciences, Beijing Normal University, China.
Zhou
Hong Jun
HJ
Lin
Kui
K
D000818:Animals; D019143:Evolution, Molecular; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D064067:Rho Guanine Nucleotide Exchange Factors
D020662:Guanine Nucleotide Exchange Factors; D064067:Rho Guanine Nucleotide Exchange Factors