title: Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus.
abstract: Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4'- O- alpha-rhamnopyranoside, apigenin 7- O- beta-glucopyranosyl-4'- O- alpha-rhamnopyranoside, tricin 7- O- beta-glucopyranoside, tricin, and isoscopoletin possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.
authors.affiliation: Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Li
authors.forename: Changxin
authors.initials: C
authors.lastname: Zhou
authors.forename: Yunxue
authors.initials: Y
authors.lastname: Pan
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Gao
authors.forename: Xiumei
authors.initials: X
authors.lastname: Wu
authors.forename: Hua
authors.initials: H
authors.lastname: Bai
authors.forename: Linfu
authors.initials: L
authors.lastname: Zhou
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.forename: Shuili
authors.initials: S
authors.lastname: Zhang
authors.forename: Shuyun
authors.initials: S
authors.lastname: Shi
authors.forename: Jiali
authors.initials: J
authors.lastname: Luo
authors.forename: Juanhua
authors.initials: J
authors.lastname: Xu
authors.forename: Liurong
authors.initials: L
authors.lastname: Chen
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Zheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004272:DNA, Mitochondrial; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D008517:Phytotherapy; D031947:Ranunculus / Q000737:chemistry*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004272:DNA, Mitochondrial; D005419:Flavonoids