Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma.
Using whole genome expression microarray technology to discover clinically relevant biomarkers for pilocytic astrocytoma (PA), the authors identified matrilin-2 as a unique mRNA overexpressed in PA. Matrilin-2 protein expression was similarly elevated in the majority of sporadic PA, but in only one neurofibromatosis 1-associated PA with an unusually aggressive clinical phenotype. These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive PA.
Sharma
M K
MK
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Watson
M A
MA
Lyman
M
M
Perry
A
A
Aldape
K D
KD
Deák
F
F
Gutmann
D H
DH
D001254:Astrocytoma / Q000145:classification / Q000175:diagnosis* / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D004252:DNA Mutational Analysis; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D005820:Genetic Testing; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D064235:Matrilin Proteins; D009456:Neurofibromatosis 1 / Q000150:complications / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
D014408:Biomarkers, Tumor; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; C577541:MATN2 protein, human; D064235:Matrilin Proteins; D012333:RNA, Messenger