Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus.
An association between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and type 1 diabetes has been described in adults, but not previously in children. Two adolescents with both CIDP and type 1 diabetes are reported here. In order to raise the awareness of CIDP among pediatricians, a description of the clinical and laboratory features, treatment, and prognosis of the condition is provided. A preliminary study was undertaken to determine whether responses to autoantigens in peri-islet Schwann cells and Schwann cells may account for the association between type 1 diabetes and CIDP. Lymphocyte proliferation in response to these autoantigens was abnormal in one of the two patients, but was also abnormal in one control subject.
Fudge
Elizabeth
E
Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA.
Carol
James
J
She
Jin-Xiong
JX
Dosch
Michael
M
Atkinson
Mark
M
Muir
Andrew
A
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000378:metabolism
D001323:Autoantibodies