title: The natural history: how has prostate cancer trend modified?
abstract: The patients' number submitted to prostate fine-needle biopsy has constantly increased in the last years, posing technical and diagnostic problems to the pathologist. The use of immunohistochemical tests can help to solve some questions. In other cases, when only a few atypical glands are present, a very cautious behaviour is the rule. The acronym "ASAP" (atypical small acinar proliferation) has been suggested in such cases.
authors.affiliation: Department of Pathology, San Carlo Borromeo Hospital, Milano, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Schiaffino
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*