Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor gamma.
A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator-activated receptor gamma with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors alpha and sigma. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-alpha and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.
Lee
Dongho
D
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
Lee
Jeong Hyung
JH
Cai
Xing Fu
XF
Shin
Jin Chul
JC
Lee
Kyeong
K
Hong
Young-Soo
YS
Lee
Jung Joon
JJ
D003512:Cyclohexanones / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D018942:Macrolides / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D047495:PPAR gamma / Q000187:drug effects / Q000378:metabolism*
D003512:Cyclohexanones; D018942:Macrolides; D047495:PPAR gamma; C453419:sorbicillinol; D009569:Nitric Oxide