title: Assessment of age-related isoniazid hepatotoxicity during treatment of latent tuberculosis infection.
abstract: BACKGROUND
  Since the introduction of new recommendations for the treatment of latent tuberculosis infection (LTB1) disregarding age as a limitation, increasing numbers of older individuals are expected to undergo treatment with isoniazid for the prevention of tuberculosis, raising the potential for an increase in isoniazid hepatotoxicity.
  
  
  OBJECTIVE
  To compare the frequency of hepatotoxicity requiring withdrawal of isoniazid therapy for LTB1 in patients under and over 35 years of age, managed according to current practice guidelines.
  
  
  METHODS
  A retrospective analysis of 300 patients who underwent isoniazid therapy for LTB1 according to a protocol based on the current practice guidelines.
  
  
  METHODS
  Public health clinic of Passaic County, NJMain outcome measures: The frequency of symptomatic isoniazid hepatitis in various age groups.
  
  
  RESULTS
  Of 165 patients < 35 years of age, 3(2%) patients developed hepatitis (AST > 3 times the upper limit of normal). Of 135 patients > or = 35 years of age, 4(3%) patients developed hepatitis. Statistical comparison between the two groups failed to show a significant difference (p = 0.705).
  
  
  CONCLUSIONS
  No difference was detected in the frequency of isoniazid hepatotoxicity between patients < 35 and > or = 35 years of age. Clinically monitored isoniazid therapy of LTB1 patients > or = 35 years of age may not predispose subjects to an increased risk of hepatotoxicity. Limitations of this work include the small sample size and the retrospective nature of the study.
authors.affiliation: Pulmonary Division, Department of Medicine, St. Joseph's Regional Medical Center, Paterson, NJ 07503, USA.
authors.forename: Hany
authors.initials: H
authors.lastname: Aziz
authors.forename: Mohammed
authors.initials: M
authors.lastname: Shubair
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Debari
authors.forename: Medhat
authors.initials: M
authors.lastname: Ismail
authors.forename: M Anees
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid