title: Polymorphism of the angiotensin-converting enzyme (ACE) and angiotesinogen (AGT) genes and their associations with blood pressure and carotid artery intima media thickness among healthy Finnish young adults--the Cardiovascular Risk in Young Finns Study.
abstract: The roles of angiotensin converting enzyme (ACE) insertion-deletion (I/D) and angiotensinogen (AGT) m235t polymorphisms in cardiovascular diseases have been investigated extensively during the past decade but results have been inconsistent. A sex-specific association between the ACE I/D polymorphism and systolic blood pressure (BP) was seen among Finnish children and adolescents previously. We investigated if these polymorphisms associate with the BP and carotid artery intima media thickness (IMT) in the same cohort during their adulthood. IMT data were available for 224 ACE I/D genotyped individuals and 202 AGT m235t genotyped individuals. Systolic and diastolic blood pressure values did not differ between ACE and AGT genotypes. Age and BMI adjusted mean IMT was 0.02 (95% CI: -0.05 to 0.02, p=0.33) and 0.03 mm (95% CI: -0.07 to 0.001, p=0.06) lower among the ID and DD genotype groups, respectively, compared to the II genotype group. MT and TT genotype groups had 0.02 mm (95% CI: -0.01 to 0.05, p=0.17) higher and 0.01 mm (95% CI: -0.04 to 0.02, p=0.59) lower mean IMT, respectively, compared to the MM genotype group. We conclude that ACE I/D and AGT m235t polymorphisms are not associated with carotid IMT in healthy young Finnish adults.
authors.affiliation: Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and The University of Tampere, Medical School, Finland.
authors.forename: Md Shaheenul
authors.initials: MS
authors.lastname: Islam
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Markus
authors.initials: M
authors.lastname: Juonala
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.forename: Nina
authors.initials: N
authors.lastname: Hutri-Kähönen
authors.forename: Katariina
authors.initials: K
authors.lastname: Kainulainen
authors.forename: Helena
authors.initials: H
authors.lastname: Miettinen
authors.forename: Leena
authors.initials: L
authors.lastname: Taittonen
authors.forename: Kimmo
authors.initials: K
authors.lastname: Kontula
authors.forename: Jorma S A
authors.initials: JS
authors.lastname: Viikari
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
mesh_terms: D000328:Adult; D000367:Age Factors; D000808:Angiotensinogen / Q000235:genetics*; D001053:Apolipoproteins / Q000032:analysis; D001794:Blood Pressure / Q000235:genetics*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000166:cytology*; D005260:Female; D005387:Finland; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017539:Tunica Intima / Q000166:cytology*
chemical_list: D001053:Apolipoproteins; D008055:Lipids; D000808:Angiotensinogen; D002097:C-Reactive Protein; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A