title: Clinical challenges in pulmonary hypertension: Roger S. Mitchell lecture.
abstract: Despite major advances in our understanding of the pathophysiologic processes leading to pulmonary arterial hypertension and recent developments in therapeutic approaches, the long-term prognosis for patients with pulmonary arterial hypertension remains unsatisfactory. Early detection and adequate clinical classification of the disease, better assessment of patients' prognosis, and improved therapeutic strategies are important challenges for clinicians in coming years.
authors.affiliation: Centre des Maladies Vasculaires Pulmonaires (UP-RES EA 2705), Service de Pneumologie et Réanimation Respiratoire, AP-HP-Université Paris Sud XI, Hôpital Antoine Béclère, Clamart, France. steeveprovencher@hotmail.com
authors.forename: Steeve
authors.initials: S
authors.lastname: Provencher
authors.forename: Xavier
authors.initials: X
authors.lastname: Jais
authors.forename: Azzedine
authors.initials: A
authors.lastname: Yaici
authors.forename: Olivier
authors.initials: O
authors.lastname: Sitbon
authors.forename: Marc
authors.initials: M
authors.lastname: Humbert
authors.forename: Gérald
authors.initials: G
authors.lastname: Simonneau
mesh_terms: D006801:Humans; D006976:Hypertension, Pulmonary / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy*