title: A phase II open-label trial of apomine (SR-45023A) in patients with refractory melanoma.
abstract: Metastatic melanoma continues to be a very difficult disease to treat. Options are limited and often have very little impact on the course of the disease. The objective of the current study was to evaluate the efficacy and safety of continuously administered Apomine (SR-45023A), a novel bisphosphonate, in patients with previously treated metastatic malignant melanoma. Adult patients with previously treated metastatic melanoma received Apomine 100 mg orally, twice daily (total dose 200 mg per day) continuously for 28 days (defined as a cycle). Treatment was continued until disease progression or unacceptable toxicity. A total of 42 patients received at least one dose of Apomine. Stable disease was achieved in 2 patients (5%). No complete or partial responses were observed. Progression free survival of at least 16 weeks was observed in 6 patients (14%). The median overall survival was 6.1 months (95% CI, 4.9-9.4 months). Time to treatment failure was 1.7 months (95% CI, 1.6-1.8 months) with Apomine therapy. By cycle 2, Apomine concentrations reached steady-state. Apomine was well tolerated with only 37% of patients experiencing any drug-related event. Abdominal pain was the most frequent adverse event occurring in 26% of patients. In conclusion, Apomine, at the current dose studied, failed to produce a 30% progression free survival rate at 16 weeks considered to be a meaningful benefit for further development.
authors.affiliation: University of Colorado, Cancer Center, 1665 North Ursula St, Mail Stop F-703, Aurora, CO 80045, USA.
authors.forename: Karl D
authors.initials: KD
authors.lastname: Lewis
authors.forename: John A
authors.initials: JA
authors.lastname: Thompson
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Weber
authors.forename: William A
authors.initials: WA
authors.lastname: Robinson
authors.forename: Steven
authors.initials: S
authors.lastname: O'Day
authors.forename: Jose
authors.initials: J
authors.lastname: Lutzky
authors.forename: Sewa S
authors.initials: SS
authors.lastname: Legha
authors.forename: Simon
authors.initials: S
authors.lastname: Floret
authors.forename: Francis
authors.initials: F
authors.lastname: Ruvuna
authors.forename: Rene
authors.initials: R
authors.lastname: Gonzalez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; C407151:apomine