title: Syndrome of inappropriate antidiuretic hormone caused by continuous lumbar spinal fluid drainage after transphenoidal surgery.
abstract: A 53-year-old acromegalic woman had cerebrospinal fluid rhinorrhoea following transphenoidal surgery for a pituitary microadenoma. A continuous lumbar spinal fluid drainage catheter was inserted and on the sixth postoperative day, she developed hyponatremia with features of syndrome of inappropriate antidiuretic hormone (SIADH) requiring hypertonic saline administration. Over-drainage is potentially hazardous and close biochemical monitoring is required. To our knowledge, this is the first reported case of SIADH caused by continuous lumbar drainage in an adult.
authors.affiliation: Endocrine Unit, Department of Medicine, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia. drlela@mail.hukm.ukm.my
authors.forename: S
authors.initials: S
authors.lastname: Norlela
authors.forename: K N
authors.initials: KN
authors.lastname: Azmi
authors.forename: B A K
authors.initials: BA
authors.lastname: Khalid
mesh_terms: D000172:Acromegaly; D000236:Adenoma / Q000601:surgery; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology / Q000628:therapy; D004322:Drainage / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use
chemical_list: D012462:Saline Solution, Hypertonic