title: Clostridium difficile associated severe enterocolitis: a feature of Hirschsprung's disease in a neonate presenting late.
abstract: We report a case of Hirschsprung's disease presenting late in the newborn period with severe enterocolitis and Clostridium difficile toxin detectable in the stool. Enterocolitis associated with Hirschsprung's disease is a potentially fatal complication that may occur at presentation or later in the life of an affected child. Its association with toxin-producing Clostridium difficile growth in the bowel may be under recognized, especially in newborns.
authors.affiliation: Department of Paediatrics, Royal Hobart Hospital, Liverpool Street, Tasmania, Australia.
authors.forename: S J
authors.initials: SJ
authors.lastname: Parsons
authors.forename: E
authors.initials: E
authors.lastname: Fenton
authors.forename: P
authors.initials: P
authors.lastname: Dargaville
mesh_terms: D001427:Bacterial Toxins / Q000302:isolation & purification; D016360:Clostridioides difficile / Q000302:isolation & purification; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology*; D005260:Female; D006627:Hirschsprung Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn
chemical_list: D001427:Bacterial Toxins; C488583:Clostridium difficile lethal toxin B