title: Comorbid migraine is associated with a negative impact on quality of life in patients with major depression.
abstract: This study investigated the impact of migraine on health-related quality of life (HRQoL) among patients with major depressive disorder (MDD). We prospectively enrolled 151 consecutive psychiatric out-patients meeting DSM-IV criteria for MDD. Migraine and other headache types were diagnosed based on the International Classification of Headache Disorders, 2nd edition (2004). The Short Form-36 (SF-36) was administered as a generic instrument of HRQoL. Among 151 patients with MDD, migraine (N = 73, 48.3%) was very common. Comorbidity of migraine predicted a significantly negative impact on all physical subscales and vitality but not on the other mental subscales of the SF-36 after controlling for depression, age and gender. The presence of migraine should be considered as an important physical symptom in clinic-based MDD samples. Simultaneous management of depression and severe headaches, especially migraine, might improve HRQoL in patients with MDD.
authors.affiliation: Department of Psychiatry, Chang-Gung Memorial Hospital and Chang-Gung University School of Medicine, Taipei, Taiwan.
authors.forename: C-I
authors.initials: CI
authors.lastname: Hung
authors.forename: C-Y
authors.initials: CY
authors.lastname: Liu
authors.forename: J-L
authors.initials: JL
authors.lastname: Fuh
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Juang
authors.forename: S-J
authors.initials: SJ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology* / Q000523:psychology*; D010045:Outpatients / Q000706:statistics & numerical data; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index