title: PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungbuk, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Dae Youn
authors.initials: DY
authors.lastname: Hwang
authors.forename: Young Kyu
authors.initials: YK
authors.lastname: Kim
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Lee
authors.forename: Im Chul
authors.initials: IC
authors.lastname: Shin
authors.forename: Ki Wan
authors.initials: KW
authors.lastname: Oh
authors.forename: Myung Koo
authors.initials: MK
authors.lastname: Lee
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lim
authors.forename: Do Young
authors.initials: DY
authors.lastname: Yoon
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Hwang
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D003620:Dantrolene / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005786:Gene Expression Regulation; D041722:Genes, Transgenic, Suicide; D018698:Glutamic Acid / Q000494:pharmacology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009154:Mutation / Q000235:genetics*; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology / Q000633:toxicity*; D016716:PC12 Cells; D053766:Presenilin-2; D021381:Protein Transport; D051381:Rats; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D008565:Membrane Proteins; D009498:Neurotoxins; D053766:Presenilin-2; D019837:Ryanodine Receptor Calcium Release Channel; D018698:Glutamic Acid; C505409:Casp3 protein, mouse; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; D003620:Dantrolene; D002118:Calcium