[Correlation between infiltration of local lesion and distant metastasis of nasopharyngeal carcinoma].
OBJECTIVE
The aim of this study was to study the correlation between local and regional infiltration and distant metastasis of nasopharyngeal carcinoma(NPC).


METHODS
Materials of 204 NPC cases primarily treated (including 101 cases with tumor free and a period of survived time for 5 or more years after radiotherapy and 103 cases with distant metastasis after radiotherapy ). The extent and the way of local aggressiveness were made sure by studying their CT. Then the single-factor and COX analysis were adopted to analyze.


RESULTS
Single-factor analysis showed the extent of aggressiveness of nasal sinuses, base of skull, cranial nerves, parapharyngeal space, laterals and number, size, fixation of neck lymph nodes of metastasis, clinical stage, T and N stage had statistical significance (P <0.05); Multi-factor analysis merely showed aggressiveness of nasal sinuses, cranial nerves, laterals and number, size of neck lymph nodes, clinical stage had statistical significance; Analysis of correlation between the situations of local aggressiveness and regional infiltration showed that the occurrence of metastasis of lymph nodes and its degree in metastasis group of post-radiotherapy was obviously higher than that in non-metastasis group (P < 0.05, P < 0.01), while the degree of local aggressiveness, the involvement of base of skull and the parapharyngeal space were not.


CONCLUSIONS
Regional infiltration and its degree are the most important and stable factors that affect the distant metastasis in NPC patients after radiotherapy, and primary lesion intrigues distant metastasis mainly through occurrence of metastasis of regional lymph nodes.
Mo
Ligen
L
Department of Head and Neck Surgery, the Affiliated Cancer Hospital, Guangxi Medical University, Nanning, 530021, China. moligen@gxmu.net.cn
Kuang
Guoqian
G
Zhang
Cheng
C
Yang
Rongning
R
Su
Danke
D
Wei
Zhengbo
Z
D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models