Role of Runx proteins in chondrogenesis.
The mammalian RUNX protein family comprises three transcription factorsRUNX1, RUNX2, and RUNX3. RUNX1 is involved in hematopoiesis, RUNX2 has multiple roles in osteogenesis and RUNX3 is associated with neural and gut development. In addition, all RUNX proteins are expressed during chondrogenesis, the process by which cartilage is formed. This review describes the involvement of Runx proteins in chondrogenesis, delineating their expression pattern and emphasizing their active roles in mesenchymal condensation, chondrocyte proliferation, and chondrocyte maturation. It also highlights how Runx proteins regulate transcription of target genes and how Runx proteins are regulated in the cartilaginous skeleton.
Yoshida
Carolina A
CA
Divisionof Oral Cytology/Cell Biology, Departmentof Developmental/Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan. fl895@cc.nagasaki-u.ac.jp
Komori
Toshihisa
T
D000595:Amino Acid Sequence; D000818:Animals; D049109:Cell Proliferation; D019902:Chondrocytes / Q000166:cytology* / Q000378:metabolism / Q000473:pathology; D020219:Chondrogenesis / Q000235:genetics*; D050657:Core Binding Factor alpha Subunits / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D008648:Mesoderm; D051379:Mice; D015533:Transcriptional Activation / Q000502:physiology
D050657:Core Binding Factor alpha Subunits