title: Currently used antimycotics: spectrum, mode of action and resistance occurrence.
abstract: The increasing incidence of fungal infections combined with the emerging problem of antifungal drug resistance have prompted investigations of the mode of action of the currently used antifungal therapeutics (antimycotics). The routinely used antimycotics can be grouped into six different classes based on their mode of action. In this review, the mode of action and antifungal spectrum of these classes are discussed, together with possible resistance development against them.
authors.affiliation: Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, B-3001 Heverlee, Belgium. isabelle.francois@biw.kuleuven.be
authors.forename: Isabelle E J A
authors.initials: IE
authors.lastname: Francois
authors.forename: An M
authors.initials: AM
authors.lastname: Aerts
authors.forename: Bruno P A
authors.initials: BP
authors.lastname: Cammue
authors.forename: Karin
authors.initials: K
authors.lastname: Thevissen
mesh_terms: D000499:Allylamine / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001393:Azoles / Q000737:chemistry / Q000494:pharmacology; D025141:Drug Resistance, Fungal; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D011090:Polyenes / Q000737:chemistry / Q000494:pharmacology; D013859:Thiocarbamates / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D011090:Polyenes; D013859:Thiocarbamates; D000499:Allylamine