Fulminant Budd-Chiari syndrome associated with polycythemia rubra vera and factor V Leiden mutation.
Budd-Chiari syndrome (BCS) is a severe disorder characterized by hepatic venous outflow obstruction. Hypercoagulable states are the major etiological factors for the development of BCS and can be identified in about 75% of patients. Multiple etiological factors can be found in the same patient. Hematologic abnormalities, especially myeloproliferative disorders, are the most common causes of BCS. Furthermore, the prevalence of factor V Leiden mutation is three times greater in patients with BCS. Although the clinical course tends to be chronic, BCS may, on rare occasions, cause acute liver failure. Herein, we report a patient who had factor V Leiden mutation and polycythemia rubra vera, presented as fulminant BCS.
Akyildiz
Murat
M
Department of Gastroenterology, Ege University Medical School, Bornova, Izmir, Turkey. akyildizmr@yahoo.com
Karasu
Zeki
Z
Dheir
Hamad
H
Osmanoglu
Necla
N
Akay
Sinan
S
Ilter
Tankut
T