title: Heart disease risk factors predict erectile dysfunction 25 years later (the Rancho Bernardo Study).
abstract: We prospectively examined common coronary artery disease (CAD) risk factors (age, smoking, hypertension, diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, and obesity) in 570 community-dwelling men, aged 30 to 69 years (mean age, 46 years) at baseline. After an average follow-up period of 25 years, incident erectile dysfunction (ED) was evaluated by the 5-item International Index of Erectile Function. Age, body mass index, and hypercholesterolemia were each significantly associated with an increased risk of ED. In all, 1 in 5 men had > or =3 risk factors and were at a 2.2-fold increased risk of ED. Improving CAD risk factors in midlife may decrease ED risk as well as CAD risk.
authors.affiliation: Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093-0607, USA. ebarrettconnor@ucsd.edu
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barrett-Connor
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002140:California / Q000453:epidemiology; D015986:Confounding Factors, Epidemiologic; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology*; D048909:Diabetes Complications / Q000503:physiopathology; D007172:Erectile Dysfunction / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology*; D005500:Follow-Up Studies; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects