title: Hyperprolinemia is not associated with childhood onset schizophrenia.
abstract: In a previous report [Jacquet et al., 2005] we have shown that mild to moderate hyperprolinemia resulting from several alterations (either a complete deletion or missense mutations) of the proline dehydrogenase (PRODH) gene located on chromosome 22q11 is a risk factor for schizoaffective disorder but not for DSM3 R schizophrenia or bipolar disorder. We now report that hyperprolinemia is not associated with childhood onset schizophrenia (COS).
authors.affiliation: INSERM U 614, Faculté de Médecine, Rouen, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Jacquet
authors.forename: Judith L
authors.initials: JL
authors.lastname: Rapoport
authors.forename: Bernadette
authors.initials: B
authors.lastname: Hecketsweiler
authors.forename: Aaron
authors.initials: A
authors.lastname: Bobb
authors.forename: Florence
authors.initials: F
authors.lastname: Thibaut
authors.forename: Thierry
authors.initials: T
authors.lastname: Frébourg
authors.forename: Dominique
authors.initials: D
authors.lastname: Campion
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D011392:Proline / Q000097:blood*; D011394:Proline Oxidase / Q000235:genetics* / Q000378:metabolism; D012559:Schizophrenia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*
chemical_list: D011392:Proline; D011394:Proline Oxidase