title: Walking with myosin V.
abstract: The cytoplasm of cells is teaming with vesicles and other cargo that are moving along tracks of microtubules or actin filaments, powered by myosins, kinesins and dyneins. Myosin V has been implicated in several types of intracellular transport. The mechanism by which myosin V moves processively along actin filaments has been the subject of many biophysical and biochemical studies and a consensus is starting to emerge about how this minute molecular motor operates.
authors.affiliation: Laboratory of Molecular Physiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1762, USA. sellersj@nhlbi.nih.gov
authors.forename: James R
authors.initials: JR
authors.lastname: Sellers
authors.forename: Claudia
authors.initials: C
authors.lastname: Veigel
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry*; D001693:Biological Transport, Active; D008954:Models, Biological; D020409:Molecular Motor Proteins; D009068:Movement; D024701:Myosin Type V / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D020409:Molecular Motor Proteins; D024701:Myosin Type V