Facile preparation and reactivity of polymer-supported N-(2-Iodyl-phenyl)-acylamide, an efficient oxidizing system.
A simple three-step preparation of polymer-supported N-(2-iodyl-phenyl)-acylamide (NIPA resin) starting from 2-iodoaniline is described. The resin was obtained with good loading levels (0.7-0.8 mmol g(-1)) and has been successfully used for efficient oxidation of a diverse collection of alcohols. Thus, treating alcohols with 1.0 equiv of the resin in 1,2-dichloroethane under reflux for 30-60 min allowed rapid and in most cases complete conversion to the corresponding carbonyl compound.
Ladziata
Uladzimir
U
Department of Chemistry and Biochemistry, University of Minnesota Duluth, 55812, USA.
Willging
Jeff
J
Zhdankin
Viktor V
VV