Synthesis and biological evaluation of novel benzimidazol/benzoxazolylethoxypiperidone oximes.
Some novel benzimidazol/benzoxazolylethoxypiperidone oximes were synthesized and their antibacterial activity against Staphylococcus aureus (NCIM-2492), Bacillus subtilis (NCIM-2439), Escherichia coli (NCIM-2345) and Pseudomonas aeruginosa (NCIM-2035) and antifungal activity against Candida albicans (NCIM-C27), Candida-6 (NCIM-C27), Candida-51 (NCIM-C27), Aspergillus niger (NCIM-590) and Aspergillus flavus (NCIM-539) have been evaluated. Compounds 26 and 27 exerted potent in vitro antibacterial activity against Bacillus subtilis, Escherichia coli and Staphylococcus aureus while compounds 26, 29 and 30 exhibited potent in vitro antifungal activity against Candida albicans, Candida-51, and Aspergillus niger.
Balasubramanian
Srinivasan
S
Department of Chemistry, Annamalai University, Tamil Nadu, India.
Aridoss
Gopalakrishnan
G
Parthiban
Paramasivam
P
Ramalingan
Chennan
C
Kabilan
Senthamaraikannan
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D001583:Benzoxazoles; D010091:Oximes