Neuropsychiatric associations of apolipoprotein E alleles in subjects with combat-related posttraumatic stress disorder.
Previous studies have reported associations between apolipoprotein E (APOE) genotype, cognitive function, and psychopathology in psychiatric populations. The authors investigated the associations between APOE allele status, memory function, and posttraumatic stress disorder (PTSD) symptom severity in PTSD subjects. Presence of the APOE 2 allele was associated with significantly worse reexperiencing symptoms and impaired memory function in this population.
Freeman
Thomas
T
North Little Rock PTSD Program, North Little Rock Veterans' Affairs Medical Center, Mail Code: 116AP/NLR, 2200 Fort Roots Drive, North Little Rock, AR 72114, USA. THOMAS.FREEMAN@MED.VA.GOV
Roca
Vincent
V
Guggenheim
Fred
F
Kimbrell
Tim
T
Griffin
W S T
WS
D000483:Alleles; D001057:Apolipoproteins E / Q000145:classification / Q000235:genetics*; D003130:Combat Disorders / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data
D001057:Apolipoproteins E