title: A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra.
abstract: BACKGROUND
  Liposomal lidocaine 4% (L.M.X.4 cream, Ferndale Laboratories Inc., Ferndale, MI, USA) has been proposed as a more rapidly acting topical anesthetic than the eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream, AstraZeneca LP, Wilmington, DE, USA) for venipuncture and laser procedures. However, their anesthetic efficacy has not been previously compared for electrosurgical destruction of superficial skin lesions.
  
  
  OBJECTIVE
  To test the hypothesis that L.M.X.4 and EMLA differ in anesthetic efficacy when applied under occlusion for 30 minutes prior to electrodesiccation of papules of dermatosis papulosa nigra.
  
  
  METHODS
  Forty adults were randomly assigned to treatment with either agent for 30 minutes under Tegaderm. The study drug was administered for an additional 30 minutes if the electrodesiccation of the first few papules was too painful.
  
  
  RESULTS
  One subject treated with EMLA versus none treated with L.M.X.4 experienced complete anesthesia after a single 30-minute application. Nineteen of 20 (95%) subjects treated with EMLA versus 18 of 20 (90%) subjects treated with L.M.X.4 required only a single application (p = .49). Pain scores after the initial 30-minute application (scale: 0 = none to 10 = very severe) were EMLA 3.3 +/- 2.2 (mean +/- SD) versus L.M.X. 4 2.9 +/- 2.0 (p = .46).
  
  
  CONCLUSIONS
  EMLA and L.M.X.4 provide comparable levels of anesthesia after a single 30-minute application under occlusion prior to electrodesiccation of superficial skin lesions.
authors.affiliation: Department of Dermatology, Columbia University Medical Center, 161 Fort Washington Avenue, 12th Floor, New York, NY 10032, USA.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Carter
authors.forename: Carol A
authors.initials: CA
authors.lastname: Coppola
authors.forename: Franco A
authors.initials: FA
authors.lastname: Barsanti
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage*; D003890:Desiccation; D004311:Double-Blind Method; D004598:Electrosurgery; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000601:surgery*; D008012:Lidocaine / Q000008:administration & dosage*; D000077442:Lidocaine, Prilocaine Drug Combination; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D011318:Prilocaine / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D000077442:Lidocaine, Prilocaine Drug Combination; D008081:Liposomes; D011318:Prilocaine; D008012:Lidocaine