Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population.
KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population.
Ivković
M
M
Institute for Psychiatry, Clinical Center of Serbia, Belgrade, Serbia and Montenegro.
Ranković
V
V
Tarasjev
A
A
Orolicki
S
S
Damjanović
A
A
Paunović
V R
VR
Romac
S
S
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*; D051640:Small-Conductance Calcium-Activated Potassium Channels / Q000235:genetics*; D018709:Statistics, Nonparametric; D018911:Trinucleotide Repeats / Q000235:genetics*; D015022:Yugoslavia
C406328:KCNN3 protein, human; D051640:Small-Conductance Calcium-Activated Potassium Channels