title: Chemotherapy-induced amenorrhea from adjuvant breast cancer treatment: the effect of the addition of taxanes.
abstract: OBJECTIVE
  Adjuvant chemotherapy for breast cancer can be associated with a variety of side effects, one of which is the induction of premature menopause in premenopausal patient. Although taxanes have increasingly been used in the adjuvant setting, there has been relatively little published on the frequency of amenorrhea related to their use.
  
  
  METHODS
  We review records of 159 premenopausal patients receiving adjuvant chemotherapy from our practice.
  
  
  RESULTS
  Altogether, 51% of all patients retained menstrual function after chemotherapy.
  
  
  CONCLUSIONS
  It was observed that patients receiving adjuvant anthracycline-based chemotherapy with sequential taxane therapy did not have a higher rate of amenorrhea than those not receiving a taxane.
authors.affiliation: Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, USA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Davis
authors.forename: Matthew
authors.initials: M
authors.lastname: Klitus
authors.forename: David M
authors.initials: DM
authors.lastname: Mintzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000568:Amenorrhea / Q000139:chemically induced*; D018943:Anthracyclines / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects*; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D013629:Tamoxifen / Q000627:therapeutic use; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018943:Anthracyclines; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D013629:Tamoxifen; D017239:Paclitaxel