title: Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission.
abstract: Cytokines and intrathecal IgG synthesis were determined in the cerebrospinal fluid (CSF) and sera to evaluate inflammatory activity in multiple sclerosis (MS) patients during clinical remission. Although the disease was stable, there had been a significant increase of proinflammatory cytokines such as TNFalpha and IFNgamma in the CSF and serum, with no significant changes of IL12 and IL10 production. The changes in the cytokine production patterns were associated with an increase of leukocytes in the CSF, as well as the presence of oligoclonal bands suggesting intrathecal IgG synthesis. These results suggest that even when the disease is clinically silent, one can observe inflammatory activity in these MS patients.
authors.affiliation: Department of Microbiology and Immunology, Medical School, University of Campinas, SP, Brazil.
authors.forename: Carlos Otávio
authors.initials: CO
authors.lastname: Brandão
authors.forename: Heloísa Helena
authors.initials: HH
authors.lastname: Ruocco
authors.forename: Alessandro dos Santos
authors.initials: Ados S
authors.lastname: Farias
authors.forename: Celina
authors.initials: C
authors.lastname: Oliveira
authors.forename: Dannie Eiko Maeda
authors.initials: DE
authors.lastname: Hallal-Longo
authors.forename: Sandra Regina
authors.initials: SR
authors.lastname: Mirandola
authors.forename: Elaine Conceição
authors.initials: EC
authors.lastname: Oliveira
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Benito Pereira
authors.initials: BP
authors.lastname: Damasceno
authors.forename: Leonilda Maria Barbosa
authors.initials: LM
authors.lastname: Santos
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D002648:Child; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D007249:Inflammation / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D043025:Oligoclonal Bands / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D015415:Biomarkers; D016207:Cytokines; D007074:Immunoglobulin G; D043025:Oligoclonal Bands