[Study on Hg2+ distribution and speciation in different tissues of rats].
Mercury is one of the important pollutants that threaten people health greatly in environment. The purpose of this paper was to determine mercury distribution and mercury binding proteins in different tissues of rat fed orally with mercuric chloride by ICP-MS and SEC-UV-ICP-MS. The result showed that liver and kidney induced large amount of metallothioneins that was found to bind to mercury, copper and zinc after mercury intake in stomach and intestines. The metallothioneins induced may be prior to combine the mercury so that it would decrease mercury binding with the other proteins that would disable their normal function.
Shen
Jin-can
JC
Department of Chemistry, The Key Laboratory of Analytical Sciences of the Ministry of Education, Xiamen University, Xiamen 361005, China.
Huang
Zhi-yong
ZY
Zhuang
Zhi-xia
ZX
Wang
Xiao-ru
XR
Frank
Lee S C
LS
D000284:Administration, Oral; D000818:Animals; D007668:Kidney / Q000737:chemistry* / Q000378:metabolism; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D008628:Mercury / Q000008:administration & dosage / Q000032:analysis*; D008668:Metallothionein / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation
D008668:Metallothionein; D008628:Mercury