Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters.
This is the first report on proteomic analysis of the cerebrospinal fluid (CSF) in unmedicated suicide attempters and non-attempters with major depressive disorder. Two-dimensional (2D) gel electrophoresis revealed that suicide attempters differed from non-attempters in one protein with an approximate molecular weight of 33 kD and an isoelectric point of 5.2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research.
Brunner
Jürgen
J
Facharzt für Psychiatrie und Psychotherapie, Munich, Germany. jkbrunnr@gmx.de
Bronisch
Thomas
T
Uhr
Manfred
M
Ising
Marcus
M
Binder
Elisabeth
E
Holsboer
Florian
F
Turck
Christoph W
CW
D000328:Adult; D002556:Cerebrospinal Fluid Proteins / Q000737:chemistry*; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid* / Q000523:psychology*; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D040901:Proteomics; D011569:Psychiatric Status Rating Scales; D013406:Suicide, Attempted / Q000523:psychology*
D002556:Cerebrospinal Fluid Proteins