Multilocular cystic renal cell carcinoma : a report of 45 cases of a kidney tumor of low malignant potential.
The 2004 World Health Organization (WHO) classification of kidney tumors recognizes multilocular cystic renal cell carcinoma (MCRCC) as a rare variant of clear cell renal cell carcinoma with a good prognosis. Available information on its clinical significance is limited. The study cohort included 45 MCRCC cases classified according to 2004 WHO criteria obtained through a multi-institutional international search. Most patients had unilateral MCRCC with no side predominance that was found incidentally; 62% were men, but women had tumors at an earlier age (P = .385). MCRCC occurred slightly more often in men than in women (1.7:1). At diagnosis, 82% of patients had stage T1 and 16%, stage T2; 1 patient had stage T3. The Fuhrman grade was 1 (62%) or 2 (38%), with smaller tumors (<or=4 cm) most likely Fuhrman grade 1 (P = .911). All 45 patients were alive with no evidence of disease at mean follow-up of 66.1 months, confirming an extremely good prognosis after surgery and a 5-year disease-specific survival rate of 100%. To rename this tumor as multilocular cystic renal cell neoplasm of low malignant potential might help urologists approach the patients conservatively.
Suzigan
Sueli
S
Laborclin Laboratory, São José do Rio Prêto, Brazil.
López-Beltrán
Antonio
A
Montironi
Rodolfo
R
Drut
Ricardo
R
Romero
Ana
A
Hayashi
Tomayoshi
T
Gentili
Ana L C
AL
Fonseca
Paulo S P
PS
deTorres
Ines
I
Billis
Athanase
A
Japp
Lucia C
LC
Bollito
Enrico
E
Algaba
Ferran
F
Requena-Tapias
Maria J
MJ
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged