Influence of sodium fluoride and caffeine on the kidney function and free-radical processes in that organ in adult rats.
An experiment was carried out on Sprague-Dawley rats (adult males) that for 50 days were administered, in the drinking water, NaF and NaF with caffeine (doses, respectively: 4.9 mg of NaF/kg body mass/24 h and 3 mg of caffeine/kg body mass/24 h). Disturbances were noted in the functioning of kidneys, which were particularly noticeable after the administration of NaF with caffeine. Changes in the functioning of kidneys were also confirmed by such parameters as the level of creatinine, urea, protein, and calcium. Modifications of the enzymatic antioxidative system (superoxide dismutase, catalase, and glutathione peroxidase) and lipid peroxidation (malondialdehyde) were also observed. Changes in the contents of the above parameters as well as pathomorphological examinations suggest increased diuresis, resulting in dehydration of the rats examined.
Birkner
Ewa
E
Department of Biochemistry, Silesian Medical University in Katowice, Jordana 19, 41-808 Zabrze, Poland.
Grucka-Mamczar
Ewa
E
Zwirska-Korczala
Krystyna
K
Zalejska-Fiolka
Jolanta
J
Stawiarska-Pieta
Barbara
B
Kasperczyk
Slawomir
S
Kasperczyk
Aleksandra
A
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002110:Caffeine / Q000008:administration & dosage / Q000633:toxicity*; D002118:Calcium / Q000097:blood; D002374:Catalase / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D005609:Free Radicals / Q000378:metabolism; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000503:physiopathology; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000378:metabolism; D014508:Urea / Q000378:metabolism
D001798:Blood Proteins; D005609:Free Radicals; D002110:Caffeine; D014508:Urea; D012969:Sodium Fluoride; D003404:Creatinine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005634:Fructose-Bisphosphate Aldolase; D002118:Calcium