title: Epithelioid malignant peripheral nerve sheath tumor involving maxillary sinus.
abstract: We present a case of epithelioid malignant peripheral nerve sheath tumor (MPNST) located in the maxillary sinus region in a young man. The clinical history was short, but at admission the neoplastic infiltration was so extensive that only diagnostic biopsy was performed. The patient received palliative treatment and died 6 months later. Histologically, the neoplasm had a predominant epithelioid component. Neoplastic tissue was vimentin, S-100, Cam 5.2 and neuron-specific enolase positive. P53 protein reaction was found in 6% of the cells and the proliferation index assessed with Ki-67 was 52%. An appropriate immunohistochemical panel was essential for the final diagnosis of this epithelioid malignant tumor, with the location rather unusual for MPNST.
authors.affiliation: Department of Pathology, Medical University of Gdansk, Debinki 7 str, 80-211 Gdansk, Poland. eczis@wp.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Izycka-Swieszewska
authors.forename: Barbara
authors.initials: B
authors.lastname: Drogoszewska
authors.forename: Joanna
authors.initials: J
authors.lastname: Filipowicz
authors.forename: Edyta
authors.initials: E
authors.lastname: Szurowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Kaminski
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Jaskiewicz
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000378:metabolism / Q000473:pathology*; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology*