Clinical profile and early surgical complications in the Cornea Donor Study.
OBJECTIVE
The Cornea Donor Study was designed to investigate the safety and efficacy of older donor corneal tissue compared with younger donor tissue in recipient eyes at moderate risk to the graft from progressive endothelial failure. Baseline patient data, including indications for transplant, intraoperative complication rates, and early postoperative complication rates are described herein.


METHODS
This study was a multicenter prospective, double-masked, controlled clinical trial.


RESULTS
Fuchs dystrophy was the most common indication for corneal transplantation (61%). Intraoperative complications occurred in 33 (3%) patients. A persistent epithelial defect was the most commonly reported postoperative complication, occurring in 92 patients (8%).


CONCLUSIONS
Intraoperative and postoperative complication rates were low. There was no apparent association between donor or recipient age and either intraoperative or early postoperative complication rates.
Mannis
Mark J
MJ
cds@jaeb.org
Holland
Edward J
EJ
Beck
Roy W
RW
Belin
Michael W
MW
Goldberg
Marc A
MA
Gal
Robin L
RL
Kalajian
Andrea D
AD
Kenyon
Kenneth R
KR
Kollman
Craig
C
Ruedy
Katrina J
KJ
Smith
Patricia
P
Sugar
Joel
J
Stark
Walter J
WJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003315:Cornea / Q000473:pathology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery; D005901:Glaucoma / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D013529:Surgical Wound Dehiscence / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D014019:Tissue Donors