Pharmacology of intracellular signalling pathways.
This article provides a brief and somewhat personalized review of the dramatic developments that have occurred over the last 45 years in our understanding of intracellular signalling pathways associated with G-protein-coupled receptor activation. Signalling via cyclic AMP, the phosphoinositides and Ca(2+) is emphasized and these systems have already been revealed as new pharmacological targets. The therapeutic benefits of most of such targets are, however, yet to be realized, but it is certain that the discipline of pharmacology needs to widen its boundaries to meet these challenges in the future.
Nahorski
Stefan R
SR
Department of Cell Physiology and Pharmacology, University of Leicester, Medical Sciences Building, University Road, Leicester LE1 9HN. srn@le.ac.uk
D000818:Animals; D020013:Calcium Signaling; D000242:Cyclic AMP / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000502:physiology; D018020:Lithium Compounds / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects* / Q000266:history / Q000502:physiology; D015290:Second Messenger Systems; D015398:Signal Transduction
D053496:Inositol 1,4,5-Trisphosphate Receptors; D018020:Lithium Compounds; D010716:Phosphatidylinositols; D043562:Receptors, G-Protein-Coupled; D000242:Cyclic AMP