Localization of human T-cell lymphotropic virus-1 gag proviral sequences in dermato-immunological disorders with eosinophilia.
The mechanisms leading to the development of eosinophilia were investigated in 65 patients with immunodermatological disorders, including the role of eosinophilotactic cytokines and the possible involvement of human T-cell leukemia virus, HTLV. HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively. Increased level of GM-CSF was detected in 33% of disorders studied. Elevated level of IL-5 and eotaxin was detected in 27% and 30%, respectively, of patients with bullous diseases. Elevated level of GM-CSF and eotaxin was found in 33% and 46%, respectively, of patients with inflammatory diseases. Neither of the four cytokines, however proved to be responsible alone or together for the induction of eosinophilia. The possible indirect role of human retroviruses through induction of eosinophilic chemotactic cytokines is hypothesized.
Nagy
K
K
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary. nagykar@net.sote.hu
Marschalkó
Márta
M
Kemény
B
B
Horváth
A
A
D001483:Base Sequence; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000097:blood; D004279:DNA, Viral / Q000737:chemistry; D004802:Eosinophilia / Q000276:immunology / Q000821:virology*; D005260:Female; D015683:Gene Products, gag / Q000737:chemistry* / Q000235:genetics; D015750:Genes, gag; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D015490:HTLV-I Infections / Q000150:complications / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015848:Interleukin-5 / Q000097:blood; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000821:virology*; D008297:Male; D011533:Proviruses / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D012871:Skin Diseases / Q000276:immunology / Q000821:virology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000821:virology*
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D004279:DNA, Viral; D015683:Gene Products, gag; D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor