Effects of intravenous diazepam or microdose medetomidine on propofol-induced sedation in dogs.
This crossover study tested the hypothesis that both diazepam and microdose medetomidine would comparably reduce the amount of propofol required to induce sedation. Four different medications, namely high-dose diazepam (0.4 mg/kg intravenously [IV]), low-dose diazepam (0.2 mg/kg IV), medetomidine (1 mug/kg IV), and placebo (0.5 mL physiological saline IV) were followed by propofol (8 mg/kg IV) titrated to a point where intubation could be performed. The effects of medetomidine were comparable to the effects of high-dose diazepam and significantly better than the effects of low-dose diazepam or placebo. Dogs in all treatment groups had transient hypoxemia, and induction and recovery qualities were similar.
Ko
Jeff C H
JC
Department of Veterinary Clinical Sciences, College of Arts and Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
Payton
Mark E
ME
White
Alison G
AG
Galloway
David S
DS
Inoue
Tomohito
T
D000771:Anesthesia, Intravenous / Q000379:methods / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D018592:Cross-Over Studies; D003975:Diazepam / Q000008:administration & dosage*; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D020926:Medetomidine / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D015742:Propofol; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide; D020926:Medetomidine; D003975:Diazepam; D010100:Oxygen; D015742:Propofol