title: Meal-induced changes in splanchnic blood flow and oxygen uptake in middle-aged healthy humans.
abstract: OBJECTIVE
  For decades, the determination of changes in splanchnic blood flow and oxygen uptake after a meal has been used in the management of patients with suspected chronic intestinal ischaemia. However, little is known about the normal meal-induced responses. The aim of the present study was therefore to measure the splanchnic blood flow and oxygen uptake before and after a standardized meal in a group of middle-aged normal volunteers.
  
  
  METHODS
  Splanchnic blood flow and oxygen uptake were determined at baseline and after a 3600-kJ mixed meal in 8 healthy women (50-70 years) and 10 healthy men (52-76 years). Splanchnic blood flow was measured during hepatic vein catheterization by indirect Fick principle with indocyanine green as the indicator. Splanchnic oxygen uptake was calculated from splanchnic blood flow and the arteriovenous oxygen difference.
  
  
  RESULTS
  The meal induced a significant peak increase in splanchnic blood flow of 0.60 (0.26-1.07) l x min(-1) (mean, range) from a baseline level of 1.05 (0.66-1.33) l x min(-1). Splanchnic oxygen uptake showed a significant peak increase of 1.40 (0.44-4.13) mmol x min(-1) from a baseline level of 2.18 (1.41-3.31) mmol x min(-1). A close association was found between the meal-induced peak increases in splanchnic blood flow and oxygen uptake, but the variables were not related to gender or body surface area of the subjects.
  
  
  CONCLUSIONS
  A 3,600-kJ mixed meal induces a significant increase in splanchnic blood flow and oxygen uptake in middle-aged healthy humans. Our data may be relevant for the evaluation of corresponding data from patients with suspected chronic intestinal ischaemia.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Denmark. jan.lysgaard.madsen@hh.hosp.dk
authors.forename: Jan L
authors.initials: JL
authors.lastname: Madsen
authors.forename: Susanne B
authors.initials: SB
authors.lastname: Søndergaard
authors.forename: Søren
authors.initials: S
authors.lastname: Møller
mesh_terms: D000368:Aged; D002302:Cardiac Output / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D013152:Splanchnic Circulation / Q000502:physiology*
chemical_list: D007208:Indocyanine Green