title: Clinical profile and early surgical complications in the Cornea Donor Study.
abstract: OBJECTIVE
  The Cornea Donor Study was designed to investigate the safety and efficacy of older donor corneal tissue compared with younger donor tissue in recipient eyes at moderate risk to the graft from progressive endothelial failure. Baseline patient data, including indications for transplant, intraoperative complication rates, and early postoperative complication rates are described herein.
  
  
  METHODS
  This study was a multicenter prospective, double-masked, controlled clinical trial.
  
  
  RESULTS
  Fuchs dystrophy was the most common indication for corneal transplantation (61%). Intraoperative complications occurred in 33 (3%) patients. A persistent epithelial defect was the most commonly reported postoperative complication, occurring in 92 patients (8%).
  
  
  CONCLUSIONS
  Intraoperative and postoperative complication rates were low. There was no apparent association between donor or recipient age and either intraoperative or early postoperative complication rates.
authors.affiliation: cds@jaeb.org
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mannis
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Holland
authors.forename: Roy W
authors.initials: RW
authors.lastname: Beck
authors.forename: Michael W
authors.initials: MW
authors.lastname: Belin
authors.forename: Marc A
authors.initials: MA
authors.lastname: Goldberg
authors.forename: Robin L
authors.initials: RL
authors.lastname: Gal
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Kalajian
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Kenyon
authors.forename: Craig
authors.initials: C
authors.lastname: Kollman
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Ruedy
authors.forename: Patricia
authors.initials: P
authors.lastname: Smith
authors.forename: Joel
authors.initials: J
authors.lastname: Sugar
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Stark
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003315:Cornea / Q000473:pathology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery; D005901:Glaucoma / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D013529:Surgical Wound Dehiscence / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D014019:Tissue Donors