title: Clonal dissemination and mupA gene polymorphism of mupirocin-resistant Staphylococcus aureus isolates from long-term-care facilities in South Korea.
abstract: We identified 25 high-level mupirocin-resistant (MuH) and 21 low-level mupirocin-resistant (MuL) Staphylococcus aureus isolates from eight long-term-care facilities (LTCFs). The pulsed-field gel electrophoresis patterns of 19 MuH and 19 MuL isolates from two facilities were identical for 18 and 15 isolates, respectively. The most predominant mupA restriction fragment length polymorphism type was found in 21 MuH isolates. We conclude that clonal transmission of MuH and MuL S. aureus strains occurred in these LTCFs. This is the first report of clonal transfer of mupirocin resistance in LTCFs.
authors.affiliation: Laboratory of Antimicrobial Resistant Pathogens, Department of Microbiology, National Institute of Health, KCDC, 194, Tonil-Lo, Eunpyung-Gu, Seoul 122-701, South Korea.
authors.forename: Jae Il
authors.initials: JI
authors.lastname: Yoo
authors.forename: Eun Shim
authors.initials: ES
authors.lastname: Shin
authors.forename: Jeong Ok
authors.initials: JO
authors.lastname: Cha
authors.forename: Jeom Kyu
authors.initials: JK
authors.lastname: Lee
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Jung
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Lee
authors.forename: Bong Su
authors.initials: BS
authors.lastname: Kim
authors.forename: Yeong Seon
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008134:Long-Term Care; D016712:Mupirocin / Q000494:pharmacology*; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D013203:Staphylococcal Infections / Q000453:epidemiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D009687:Nuclear Proteins; C480380:mupA protein, Staphylococcus aureus; D016712:Mupirocin