Lipid class distribution of fatty acids including conjugated linoleic acids in healthy and cancerous parts of human kidneys.
In this study the FA compositions of healthy and cancerous human renal tissues from the same patients are compared with special reference to the CLA and PUFA content. CLA was preferentially incorporated into neutral lipid compared with phospholipid classes. Its distribution profile was similar to that of monounsaturated FA, but unlike that found with 18:2n-6. Different incorporation patterns were found for individual CLA isomers. Comparing renal cell carcinoma (RCC) and healthy kidney, the total CLA content was significantly lower in the cholesterylester fraction and significantly higher in the PE and PS fractions from RCC. The most significant differences between healthy and cancerous renal tissue were in the content of t10,c12-CLA. Furthermore, the lipid class distributions of n-6 PUFA were determined, and several significant differences between RCC and healthy renal tissue were found. This is of interest, as it has been proposed that the anticarcinogenic properties of dietary CLA are associated with their interference in the metabolism of 20:4n-6. The involvement of CLA in preventing renal cancer cannot be definitively demonstrated from the design of this study, nor was it intended, but the complete determination of the FA composition of adjacent healthy and cancerous tissues may provide an insight if lipids are involved in this disease.
Hoffmann
Kristina
K
lnstitute of Biochemistry and Food Chemistry, University of Hamburg, Germany.
Blaudszun
Jörg
J
Brunken
Claus
C
Höpker
Wilhelm-Wolfgang
WW
Tauber
Roland
R
Steinhart
Hans
H
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000473:pathology; D005227:Fatty Acids / Q000032:analysis*; D043371:Fatty Acids, Omega-6 / Q000032:analysis; D005260:Female; D006801:Humans; D007536:Isomerism; D007668:Kidney / Q000737:chemistry* / Q000473:pathology; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology; D044243:Linoleic Acids, Conjugated / Q000032:analysis*; D008055:Lipids / Q000032:analysis / Q000737:chemistry; D008297:Male; D008875:Middle Aged
D005227:Fatty Acids; D043371:Fatty Acids, Omega-6; D044243:Linoleic Acids, Conjugated; D008055:Lipids