Cyclodextrin-grafted polysaccharides as supramolecular carrier systems for naproxen.
Dextran, mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with beta-cyclodextrin moieties by reductive alkylation in the presence of sodium borohydride. These polymers were used as supramolecular carriers for naproxen, improving the "in vivo" anti-inflammatory properties of this drug.
Ramírez
Héctor L
HL
Enzyme Technology Group, University of Matanzas, Matanzas 44740, Cuba.
Valdivia
Aymara
A
Cao
Roberto
R
Torres-Labandeira
Juan J
JJ
Fragoso
Alex
A
Villalonga
Reynaldo
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002273:Carcinogens / Q000737:chemistry; D002351:Carrageenan / Q000633:toxicity; D003911:Dextrans / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008351:Mannans / Q000737:chemistry*; D009288:Naproxen / Q000737:chemistry*; D010084:Oxidation-Reduction; D010504:Periodic Acid; D051381:Rats; D017208:Rats, Wistar; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002273:Carcinogens; D003911:Dextrans; D004337:Drug Carriers; D008351:Mannans; D047392:beta-Cyclodextrins; D010504:Periodic Acid; D009288:Naproxen; D002351:Carrageenan; C009288:metaperiodate; C031215:betadex; D002266:Carboxymethylcellulose Sodium