title: HPLC investigated physicochemical compatibility between Artrosilene injectable solution and other pharmaceutical products frequently used for combined therapy into elastomeric Baxter LV5 infusion devices.
abstract: Ketoprofen lysine salt(Artrosilene injectable solution) is a non-steroidal anti-inflammatory agent frequently administered by slow intravenous infusion with portable elastomeric infusion systems in association regimen with other analgesic drugs. The aim of this study was to investigate the physicochemical compatibility between ketoprofen lysine salt(Artrosilene injectable solution) and other injectable drugs frequently used in association, such as tramadol hydrochloride, keterolac tromethamine and morphine hydrochloride, into the Infusor LV5, Baxter elastomeric infusion system. Physicochemical properties of drug mixture, including colour, clarity, pH and drug content were observed or measured by a reversed-phase HPLC method with UV detection, before and after (up to 7 days) mixing at room temperature and under light protection. The results obtained demonstrated the physicochemical compatibility of ketoprofen lysine salt(Artrosilene injectable solution) with all drug formulations at every tested mixing ratios into Baxer Infusor LV5 infusion devices.
authors.affiliation: Dompé Research and Development, Pharmaceutical Development Department, Dompé SpA, L'Aquila, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Anacardio
authors.forename: S
authors.initials: S
authors.lastname: Bartolini
authors.forename: M M
authors.initials: MM
authors.lastname: Gentile
authors.forename: M
authors.initials: M
authors.lastname: Bagnasco
authors.forename: G
authors.initials: G
authors.lastname: Carlucci
mesh_terms: D000701:Analgesics, Opioid / Q000032:analysis / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D003116:Color; D004338:Drug Combinations; D004344:Drug Incompatibility; D004349:Drug Packaging; D020724:Elastomers; D006863:Hydrogen-Ion Concentration; D007260:Infusion Pumps; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D020911:Ketorolac Tromethamine / Q000032:analysis / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D009020:Morphine / Q000032:analysis / Q000737:chemistry; D019999:Pharmaceutical Solutions; D014147:Tramadol / Q000032:analysis / Q000737:chemistry
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D020724:Elastomers; D019999:Pharmaceutical Solutions; D014147:Tramadol; D020911:Ketorolac Tromethamine; C029946:ketoprofen lysine; D009020:Morphine; D007660:Ketoprofen; D008239:Lysine