title: Clinical impact of ganciclovir-resistant cytomegalovirus infections in solid organ transplant patients.
abstract: Clinical consequences of ganciclovir resistant cytomegalovirus (CMV) infections were studied during 2 large prophylactic trials consisting of 100 days of valganciclovir or ganciclovir prophylaxis in solid organ transplant (SOT) recipients. The first one involved 301 high-risk (CMV donor seropositive/recipient seronegative) SOT recipients excluding lung transplants followed for 12 months, whereas the second one involved 80 lung transplant patients evaluated over 6 months. Among the 7 patients (4 non-lung and 3 lung transplant patients) carrying viruses with known ganciclovir-resistance [corrected] mutations in blood, adverse clinical outcome was only observed in the lung transplant recipients. Additionally, no CMV resistance mutations were observed in non-lung transplant patients receiving valganciclovir.
authors.affiliation: Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Quebec City, Quebec, Canada. guy.boivin@crchul.ulaval.ca
authors.forename: G
authors.initials: G
authors.lastname: Boivin
authors.forename: N
authors.initials: N
authors.lastname: Goyette
authors.forename: C
authors.initials: C
authors.lastname: Gilbert
authors.forename: A
authors.initials: A
authors.lastname: Humar
authors.forename: E
authors.initials: E
authors.lastname: Covington
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018890:Chemoprevention; D003587:Cytomegalovirus / Q000187:drug effects / Q000235:genetics; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000821:virology; D024882:Drug Resistance, Viral / Q000235:genetics; D015774:Ganciclovir / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects; D009154:Mutation; D016377:Organ Transplantation / Q000009:adverse effects*; D016896:Treatment Outcome; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir