title: Circulating oxidized LDL is associated with increased waist circumference independent of body mass index in men and women.
abstract: BACKGROUND
  Obesity is associated with oxidative stress, and the oxidation of LDL is thought to play a crucial role in the generation of atherosclerotic lesions.
  
  
  OBJECTIVE
  The objective was to describe the association of waist circumference (WC) and body mass index (BMI; in kg/m2) with plasma circulating oxidized LDL (ox-LDL) and C-reactive protein (CRP).
  
  
  METHODS
  This cross-sectional study included data for circulating ox-LDL and CRP from a subpopulation of 586 men and women enrolled in a population-based survey conducted in 2000 in Girona, Spain. Multivariate analysis was performed to describe the independent association of WC and BMI with ox-LDL and CRP.
  
  
  RESULTS
  Multivariate logistic regression analysis adjusted for lifestyle, educational level, and dietary confounders showed a direct association of WC (quartile distribution) and BMI categories with ox-LDL (P for linear trend = 0.002) and CRP (P for linear trend = 0.004). Subjects in the top quartile of WC and with a BMI > 29.9 were at high risk of elevated circulating concentrations of ox-LDL and CRP. Further adjustment for cardiovascular disease risk factors did not substantially modify these associations. The risk of high ox-LDL concentrations in overweight (BMI = 25.0-29.9) or obese (BMI > or = 30) subjects with a WC < 102 cm (men) or < 88 cm (women) was not significantly different from that in normal-weight subjects with these WCs. In contrast, overweight or obese subjects with higher WCs (WC > or = 102 cm for men and > or = 88 cm for women) were at significantly higher risk of increased ox-LDL.
  
  
  CONCLUSIONS
  High WC was associated with high concentrations of ox-LDL independently of BMI in the study population.
authors.affiliation: Department of Public Health, Universidad Miguel Hernández, Campus San Juan, Alicante, Spain.
authors.forename: Tanja
authors.initials: T
authors.lastname: Weinbrenner
authors.forename: Helmut
authors.initials: H
authors.lastname: Schröder
authors.forename: Veronica
authors.initials: V
authors.lastname: Escurriol
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fito
authors.forename: Roberto
authors.initials: R
authors.lastname: Elosua
authors.forename: Joan
authors.initials: J
authors.lastname: Vila
authors.forename: Jaume
authors.initials: J
authors.lastname: Marrugat
authors.forename: Maria-Isabel
authors.initials: MI
authors.lastname: Covas
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors; D049629:Waist-Hip Ratio
chemical_list: D008077:Lipoproteins, LDL; D002097:C-Reactive Protein