title: Virtual commissioning of a treatment planning system for proton therapy of ocular cancers.
abstract: The virtual commissioning of a treatment planning system (TPS) for ocular proton beam therapy was performed using Monte Carlo (MC) simulations and a model of a double-scattering ocular treatment nozzle. The simulations produced both the input data required by the TPS and the dose distributions to validate the analytical predictions from the TPS. An MC simulation of a typical ocular melanoma treatment was compared with the TPS predictions, revealing generally good agreement in the absorbed dose distribution. However, in the depth-dose profiles, differences >5% existed in the proximal region of all validation cases considered. Comparison of the radiation coverage at or above the 90% dose level, showed that MC calculated coverage was 82% and 68% of the coverage calculated by the TPS in two planes intersecting the tumour.
authors.affiliation: M.D. Anderson Cancer Center, Unit 130, The University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA. nckoch@mdanderson.org
authors.forename: N
authors.initials: N
authors.lastname: Koch
authors.forename: W
authors.initials: W
authors.lastname: Newhauser
mesh_terms: D001822:Body Burden; D003198:Computer Simulation; D005134:Eye Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity; D061766:Proton Therapy; D011835:Radiation Protection / Q000379:methods*; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000592:standards; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012984:Software; D012986:Software Validation; D013781:Texas; D014584:User-Computer Interface; D011522:Protons
chemical_list: D011522:Protons