New benzimidazoles as thrombopoietin receptor agonists.
A novel benzimidazole series of small-molecule thrombopoietin receptor agonists has been discovered. Herein, we discuss the preliminary exploration of structure-activity relationships within this chemotype.
Safonov
Igor G
IG
Medicinal Chemistry and Oncology Research Departments, Microbial, Musculoskeletal and Proliferative Diseases, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. igor.2.safonov@gsk.com
Heerding
Dirk A
DA
Keenan
Richard M
RM
Price
Alan T
AT
Erickson-Miller
Connie L
CL
Hopson
Christopher B
CB
Levin
Jenna L
JL
Lord
Kenneth A
KA
Tapley
Peter M
PM
D000143:Acids / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry; D018121:Receptors, Cytokine / Q000819:agonists* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013926:Thrombopoietin / Q000378:metabolism*
D000143:Acids; D001562:Benzimidazoles; D009284:Naphthols; D018121:Receptors, Cytokine; D013926:Thrombopoietin; C031000:benzimidazole