title: Synthesis of some oxazolinones and imidazolinones and their antimicrobial screening.
abstract: A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phe- nyl-4-acetylidene/benzylidene-imidazolin-5[4H]-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff's bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5[4H]-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imi- dazolin-5[4H]-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.
authors.affiliation: Regional Institute of Pharmaceutical Science & Technology, Abhoynagar Agartala, Tripura-799005, India. biplab_32@yahoo.co.in
authors.forename: Biplab
authors.initials: B
authors.lastname: De
authors.forename: Jayanta Kumar
authors.initials: JK
authors.lastname: Gupta
authors.forename: Venkatapuram Sampath
authors.initials: VS
authors.lastname: Saravanan
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D048288:Imidazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D048288:Imidazolines; D010080:Oxazoles