Frailty and the aging male.
Frailty occurs in aging males for a variety of reasons. It is less common in males than females. Diseases which are particularly associated with frailty are diabetes mellitus, atherosclerosis, anemia and chronic obstructive pulmonary disease. Insulin resistance syndrome plays a pathogenetic role in the "fat-frail" syndrome. Sarcopenia occurs predominantly because of hormone deficiency and cytokine excess. Pain and anorexia are also associated with frailty. Stem cell research represents a potential promise for the treatment of frailty.
Morley
J E
JE
GRECC, VA Medical Center, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA. morley@slu.edu
Kim
M J
MJ
Haren
M T
MT
Kevorkian
R
R
Banks
W A
WA
D000367:Age Factors; D000368:Aged; D000375:Aging / Q000473:pathology / Q000502:physiology*; D016207:Cytokines; D018450:Disease Progression; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D016036:Seroepidemiologic Studies
D016207:Cytokines