Spontaneous remission of acute myeloid leukemia associated with GnRH agonist treatment.
Spontaneous remission of acute myeloid leukemia (AML) in adults is a rare but well documented phenomenon. This study reports on a 64-year-old male patient with acute myelogenous leukemia (AML-M4, according to the French-American-British classification) that was developed on a background of chronic myelomonocytic leukemia (CMML) and then underwent remission after treatment with the gonadotropin-releasing hormone agonist (GnRH agonist) triptorelin for presumed prostate cancer. Remission persisted for at least 4 years before the patient was lost to follow-up. To the author' knowledge, this is the first report of remission in an AML-M4 case associated with hormone manipulation. Possible mechanisms of this phenomenon are discussed.
Tsavaris
Nicolas
N
Department of Pathophysiology, Medical Oncology Unit, 'Laikon' General Hospital, Athens University School of Medicine, Athens, Greece.
Kopterides
Petros
P
Kosmas
Christos
C
Siakantaris
Marina
M
Patsouris
Evangelos
E
Pangalis
Gerasimos
G
D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone