Chemo-enzymatic synthesis of raffinose-branched polyelectrolytes and self-assembly application in microcapsules.
A novel biocompatible polyelectrolyte poly(vinyl raffinose-co-acrylic acid) (PRCA) containing a raffinose branch was prepared via redox polymerization using Fe(2+)/K(2)S(2)O(8)/H(2)O(2) starting from enzymatically-synthesized monomer: 1-O-vinyldecanedioyl raffinose. Copolymers with different monomer feed ratios were prepared and characterized with IR, NMR, and GPC. PRCA can be alternated with polycation to form microcapsules on a crystals template by electrostatic layer-by-layer technique. The multilayers of PRCA/poly(methacryloyloxyethyl dimethylbenzyl ammonium chloride) (PMBA) on quartz slides and PRCA/poly(dimethyldiallyl ammonium chloride) (PDDA) on acyclovir crystals template were fabricated and characterized with UV-Vis spectra, the microelectrophoretic measurement, and TEM. Hollow capsules can be formed after the removal of acyclovir crystals template in a buffer solution. The nano-capsule-carrying galactose residue is a potential targeting drug-controlled delivery systems.
Wu
Qi
Q
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Chen
Zhi-Chun
ZC
Lu
De-Shui
DS
Lin
Xian-Fu
XF
D000179:Acrylates / Q000737:chemistry*; D000212:Acyclovir; D001672:Biocompatible Materials; D002850:Chromatography, Gel; D016503:Drug Delivery Systems / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D011095:Polyethylenes / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D011887:Raffinose / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D000179:Acrylates; D001672:Biocompatible Materials; D011095:Polyethylenes; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; C036658:acrylic acid; D011887:Raffinose; D000212:Acyclovir