Protection of proteins from oxidative stress: a new illusion or a novel strategy?
Proteins damaged by oxidative stress have the most dangerous consequences. Oxidized protein derivatives inveigle lipids and carbohydrates into metabolic transformations that result in loss of protein functions and accumulation of glycated proteins and advanced glycated end products, which are difficult to remove from living tissues. Hydrophobic antioxidants are not very effective in protecting proteins from oxidative modification. At the same time, the natural hydrophilic antioxidant and anti-glycating agent carnosine efficiently prevents oxidative modification of proteins and increases the life span of experimental animals under unfavorable conditions. It can be considered a potent natural geroprotector.
Boldyrev
Alexander A
AA
M.V. Lomonosov Moscow State University and Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia . aaboldyrev@mail.ru
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002336:Carnosine / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008017:Life Expectancy; D015227:Lipid Peroxidation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D038204:beta-Crystallins / Q000378:metabolism
D011506:Proteins; D017382:Reactive Oxygen Species; D038204:beta-Crystallins; D002336:Carnosine; D002118:Calcium