Role of 1,4-benzothiazine derivatives in medicinal chemistry.
1,4-Benzothiazine (1,4-BT) derivatives have been reported to exhibit a wide range of pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-rheumatic, anti-allergic, vasorelaxant, anti-arrhythmic, anti-hypertensive, neuroprotective and cytotoxic activities. These different effects indicate that 1,4-BT is a template potentially useful in medicinal chemistry research and therapeutic applications.
Fringuelli
R
R
Department of Drug Chemistry and Technology, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy. fringuel@unipg.it
Milanese
L
L
Schiaffella
F
F
D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D018501:Antirheumatic Agents / Q000737:chemistry / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000037:antagonists & inhibitors / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism; D013843:Thiazines / Q000737:chemistry* / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology
C446962:1,4-benzothiazine; D018926:Anti-Allergic Agents; D000889:Anti-Arrhythmia Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D018501:Antirheumatic Agents; D015220:Calcium Channels; D018696:Neuroprotective Agents; D015221:Potassium Channels; D013843:Thiazines; D014665:Vasodilator Agents; D042965:Methylenetetrahydrofolate Reductase (NADPH2)