title: Aggressive central nervous system demyelination in an adolescent.
abstract: A 15-year-old boy diagnosed with a severe, active, and aggressive form of multiple sclerosis (MS) failed conventional, evidence-based therapy. The optimal treatment of the child or adolescent failing federally approved therapy for MS is unclear, similar to the situation in adults. This case history demonstrates that aggressive immunosuppression might be of at least short-term value in controlling disease acutely in an adolescent, as in adults with MS, when evidence-based therapies do not provide an adequate response.
authors.affiliation: Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, and The Valley Hospital, Ridgewood, NJ, USA.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Solanky
authors.forename: Daniel
authors.initials: D
authors.lastname: Van Engel
authors.forename: Leo
authors.initials: L
authors.lastname: Wolansky
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Cook
mesh_terms: D000293:Adolescent; D017338:Cladribine / Q000008:administration & dosage*; D003711:Demyelinating Diseases / Q000188:drug therapy* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D007166:Immunosuppressive Agents; D017338:Cladribine