title: Arthropod-derived protein EV131 inhibits histamine action and allergic asthma.
abstract: Histamine is an important mediator of allergic responses. Arthropods express several biologically active proteins in their saliva, which may allow a prolonged blood meal on the host. Proteins identified and expressed include histamine, serotonin, tryptase, and complement binding proteins. We review here data that scavenging of endogenous histamine by the histamine-binding protein EV131 has a profound inhibitory effect on allergic asthma. Aerosol administration of EV131 prevented airway hyperreactivity and abrogated peribronchial inflammation, eosinophil recruitment, mucus hypersecretion, and IL-4 and IL-5 secretion. Saturation with histamine abrogated the inhibitory effect of EV131 on bronchial hyperreactivity. The data suggest that histamine plays a role in allergies and that scavenging of histamine by EV131 may represent a novel therapeutic strategy in the treatment of allergic diseases.
authors.affiliation: Evolutec Ltd., Reading, United Kingdom.
authors.forename: Wynne
authors.initials: W
authors.lastname: Weston-Davies
authors.forename: Isabelle
authors.initials: I
authors.lastname: Couillin
authors.forename: Silvia
authors.initials: S
authors.lastname: Schnyder
authors.forename: Bruno
authors.initials: B
authors.lastname: Schnyder
authors.forename: Rene
authors.initials: R
authors.lastname: Moser
authors.forename: Olga
authors.initials: O
authors.lastname: Lissina
authors.forename: Guido C
authors.initials: GC
authors.lastname: Paesen
authors.forename: Patricia
authors.initials: P
authors.lastname: Nuttall
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ryffel
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001181:Arthropods; D002352:Carrier Proteins / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D011506:Proteins / Q000627:therapeutic use*
chemical_list: D018927:Anti-Asthmatic Agents; D002352:Carrier Proteins; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D011506:Proteins