title: Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis.
abstract: METHODS
  Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes.
  
  
  CONCLUSIONS
  Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression-related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.
authors.affiliation: Department of Pathology, University of Western Ontario, London, Ont.
authors.forename: Kamilia
authors.initials: K
authors.lastname: Rizkalla
authors.forename: Sylvia
authors.initials: S
authors.lastname: Rodrigues
authors.forename: Alain
authors.initials: A
authors.lastname: Proulx
authors.forename: David P
authors.initials: DP
authors.lastname: Tingey
authors.forename: J Godfrey
authors.initials: JG
authors.lastname: Heathcote
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D015353:Eye Enucleation; D005260:Female; D013700:Giant Cell Arteritis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects*; D019572:Retinal Neoplasms / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D007166:Immunosuppressive Agents; D008727:Methotrexate