title: Preparation and evaluation of solid dispersions of nitrendipine prepared with fine silica particles using the melt-mixing method.
abstract: Solid dispersions (SD) of nitrendipine (NTD), a poorly water-soluble drug, were prepared using the melt-mixing method with hydrophilic silica particles (Aerosil and Sylysia) with different particle size and specific surface areas as carriers. Powder X-ray diffraction and differential scanning calorimetry evaluation showed that NTD in the SDs treated with the melt-mixing method was dispersed in the amorphous state. FT-IR spectroscopy obtained with the SDs indicated the presence of hydrogen bonding between the secondary amine groups of NTD and silanol groups of silica particles. The dissolution property of NTD in the SDs was remarkably improved regardless of the grade of silica. At the end of the dissolution test (60 min) the concentrations of NTD for the SDs with Aerosil 200 and Sylysia 350 were 8.88 and 10.09 microg/ml, corresponding to 28 and 31 times that of the original NTD crystals, respectively. The specific surface area and the adsorbed water amount of the SDs were also significantly improved. The rapid dissolution rate from the SDs was attributed to the amorphization of drug, improved specific surface area and wettability than the original drug crystals. In the stability test, powder X-ray diffraction pattern indicated that amorphous NTD in the SD with Aerosil 200 was stable for at least 1 month under the humid conditions (40 degrees C/75% RH).
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Fu De
authors.initials: FD
authors.lastname: Cui
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Sunada
mesh_terms: D000327:Adsorption; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D008855:Microscopy, Electron, Scanning; D009568:Nitrendipine / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D002121:Calcium Channel Blockers; D012822:Silicon Dioxide; D009568:Nitrendipine