No association between the microsatellite polymorphism (TTTTA)n in the promoter of the CYP11A gene and ovarian hyperstimulation syndrome.
OBJECTIVE
Women with ultrasonic evidence of polycystic ovaries are at higher risk of ovarian hyperstimulation syndrome (OHSS). We focused on investigating a possible association of the (TTTTA)(n) microsatellite polymorphism in the promoter of the CYP11A gene with OHSS during controlled ovarian hyperstimulation (COH).


METHODS
We evaluated 58 patients at high risk of OHSS (study group) and 58 control patients undergoing controlled ovarian hyperstimulation.


RESULTS
The difference in the allele distribution between both groups of patients was not statistically significant. The genotype distribution of 4+ (with at least one copy of the four-repeat-unit allele) and 4- (without the four-repeat-unit allele) genotypes was identical in the two groups.


CONCLUSIONS
An association between the (TTTTA)(n) microsatellite polymorphism in the promoter of the CYP11A gene and the pathogenesis of OHSS could not be confirmed.
Ferk
Polonca
P
Department of Obstetrics and Gynaecology, Division of Medical Genetics, University Medical Centre, SI-1000 Ljubljana, Slovenia.
Gersak
Ksenija
K
Teran
Natasa
N
D000483:Alleles; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D016471:Ovarian Hyperstimulation Syndrome / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012306:Risk
D002786:Cholesterol Side-Chain Cleavage Enzyme