[Diseases associated with protein aggregation].
The so-called conformational diseases constitute a specific subtype of protein folding diseases that is characterized by abnormal aggregation of improperly folded polypeptides. This review describes a series of examples of such disorders and summarizes the present knowledge on their molecular pathophysiology and new therapeutic strategies.
Bak
Daniel
D
Pracownia Biologii Komórki, Zakład Genetyki Medycznej, Instytut Matki i Dziecka, Warszawa. dbak@imid.med.pl
Milewski
Michał
M
D000544:Alzheimer Disease / Q000503:physiopathology; D000682:Amyloid / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology; D000818:Animals; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology; D046912:Multiprotein Complexes; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D017096:Prion Diseases / Q000503:physiopathology; D011328:Prions / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D011489:Protein Denaturation; D017510:Protein Folding; D019896:alpha 1-Antitrypsin Deficiency / Q000378:metabolism
D000682:Amyloid; D046912:Multiprotein Complexes; D010455:Peptides; D011328:Prions