Diagnostic value of tumor markers for differentiating malignant and benign pleural effusions of Iranian patients.
In order to evaluate the diagnostic yield of tumor markers in differentiating malignant and benign pleural effusions, we carried out a prospective study in a group of Iranian people. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA 15-3), neuron-specific enolase (NSE) and cancer antigen 125 (CA 125) were assayed prospectively in patients with pleural effusion (40 malignant and 37 benign). The highest sensitivity was obtained with a combination of CA 15-3 in serum, and CA 15-3 and CEA in pleural fluid (80%), also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in pleural fluid (80%). The highest specificity was obtained with combination of CA 15-3 in serum, and CA 15-3 and NSE in pleural fluid (100%), and also with combination of CA 15-3 in serum, and CA15-3, NSE and CEA in pleural fluid (100%).
Ghayumi
Sied Mohammad Ali
SM
Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. ghayyoumim@sums.ac.ir
Mehrabi
Samrad
S
Doroudchi
Mehrnossh
M
Ghaderi
Abbas
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D018394:CA-125 Antigen / Q000032:analysis / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000097:blood; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D002648:Child; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis / Q000097:blood; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000097:blood; D010996:Pleural Effusion / Q000097:blood / Q000175:diagnosis*; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D010751:Phosphopyruvate Hydratase