title: Spirometry is related to perinatal outcomes in pregnant women with asthma.
abstract: OBJECTIVE
  The purpose of this study was to test the hypothesis that maternal asthma symptoms and pulmonary function are related to adverse perinatal outcomes.
  
  
  METHODS
  Asthmatic patients were recruited from the 16 centers of the Maternal Fetal Medicine Units. Forced expiratory volume in 1 second was obtained at enrollment and at monthly study visits, and the frequency of asthma symptoms was assessed from enrollment to delivery. Perinatal data were obtained at postpartum chart reviews.
  
  
  RESULTS
  The final cohort included 2123 participants with asthma. After adjustment for demographic characteristics, smoking, acute asthmatic episodes, and oral corticosteroid use, significant relationships were demonstrated between gestational hypertension and preterm birth and lower maternal gestational forced expiratory volume in 1 second. The data did not show any significant independent relationship between asthma symptom frequency and perinatal outcomes.
  
  
  CONCLUSIONS
  Lower pulmonary function during pregnancy is associated with increased gestational hypertension and prematurity in the pregnancies of women with asthma, which may be due to inadequate asthma control or factors that are associated with increased asthma severity.
authors.affiliation: Department of Allergy, Kaiser Permanente, San Diego, CA, USA. michael.x.schatz@kp.org
authors.forename: Michael
authors.initials: M
authors.lastname: Schatz
authors.forename: Mitchell P
authors.initials: MP
authors.lastname: Dombrowski
authors.forename: Robert
authors.initials: R
authors.lastname: Wise
authors.forename: Valerija
authors.initials: V
authors.lastname: Momirova
authors.forename: Mark
authors.initials: M
authors.lastname: Landon
authors.forename: William
authors.initials: W
authors.lastname: Mabie
authors.forename: Roger B
authors.initials: RB
authors.lastname: Newman
authors.forename: Dwight J
authors.initials: DJ
authors.lastname: Rouse
authors.forename: Marshall
authors.initials: M
authors.lastname: Lindheimer
authors.forename: Menachem
authors.initials: M
authors.lastname: Miodovnik
authors.forename: Steve N
authors.initials: SN
authors.lastname: Caritis
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Leveno
authors.forename: Paul
authors.initials: P
authors.lastname: Meis
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Wapner
authors.forename: Richard H
authors.initials: RH
authors.lastname: Paul
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: O'Sullivan
authors.forename: Michael W
authors.initials: MW
authors.lastname: Varner
authors.forename: Gary R
authors.initials: GR
authors.lastname: Thurnau
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Conway
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology*; D015331:Cohort Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D015994:Incidence; D008168:Lung / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000503:physiopathology*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D016032:Randomized Controlled Trials as Topic; D013147:Spirometry