title: Cytotoxic activity of some natural and synthetic sesquiterpene lactones.
abstract: Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane, heliangolane and their hydroxy analogues 9 and 10, all containing an alpha,beta-unsaturated aldehyde substituent, were the most potent compounds.
authors.affiliation: Dipartimento di Chimica Organica, Università di Palermo, Palermo, Italy. bruno@dicpm.unipa.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosselli
authors.forename: Antonella
authors.initials: A
authors.lastname: Maggio
authors.forename: Rosa Angela
authors.initials: RA
authors.lastname: Raccuglia
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D045744:Cell Line, Tumor; D031179:Centaurea / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D007783:Lactones; D012717:Sesquiterpenes