title: Liquid nitrogen cryotherapy of advancing wavelike epitheliopathy.
abstract: OBJECTIVE
  To describe a method for treating advancing wavelike epitheliopathy (AWE) with liquid nitrogen cryotherapy spray.
  
  
  METHODS
  A Brymill liquid nitrogen cryotherapy canister with a "D" tip was used to freeze AWE in 5 cases in 4 patients. Freezing time was approximately 1-2 seconds and was performed twice. The affected limbus and corneal epithelium were treated in this manner.
  
  
  RESULTS
  In each case, AWE resolved within 2 weeks, with no recurrence at 1 year.
  
  
  CONCLUSIONS
  Liquid nitrogen cryotherapy is a safe and effective treatment of advancing wavelike epithelopathy.
authors.affiliation: The Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA. eyedrug@ohsu.edu
authors.forename: Frederick Web
authors.initials: FW
authors.lastname: Fraunfelder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003316:Corneal Diseases / Q000473:pathology / Q000628:therapy*; D017679:Cryotherapy / Q000379:methods*; D019573:Epithelium, Corneal / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009584:Nitrogen / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D009584:Nitrogen