title: Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin.
abstract: A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions immediately after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms.
authors.affiliation: Medical Inflammation Research, Lund University, Sweden. victor.matheu@med.lu.se
authors.forename: Victor
authors.initials: V
authors.lastname: Matheu
authors.forename: Eva
authors.initials: E
authors.lastname: Perez
authors.forename: Marta
authors.initials: M
authors.lastname: Hernández
authors.forename: Elisa
authors.initials: E
authors.lastname: Díaz
authors.forename: Ricardo
authors.initials: R
authors.lastname: Darias
authors.forename: Abel
authors.initials: A
authors.lastname: González
authors.forename: Jose C
authors.initials: JC
authors.lastname: García
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Sánchez
authors.forename: Laura
authors.initials: L
authors.lastname: Feliciano
authors.forename: Agueda
authors.initials: A
authors.lastname: Caballero
authors.forename: Fernando
authors.initials: F
authors.lastname: de la Torre