title: Ocular argyrosis after long-term self-application of eyelash tint.
abstract: OBJECTIVE
  To report cases of ocular argyrosis that developed after long-term self-application of commercially available eyelash tint.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Case review, clinicopathologic analysis, and literature review.
  
  
  RESULTS
  Three patients developed ocular argyrosis after the long-term self-application of Revlon Professional Roux Lash and Brow Tint (Colomer USA Corp, New York, New York, USA). Clinical evaluation revealed various degrees of silver deposition on the upper eyelid, lid margin, caruncle and conjunctiva, and diffuse Descemet's membrane deposits. In one case, histologic examination demonstrated silver deposition in the basement membrane and superficial substantia propria of the conjunctiva.
  
  
  CONCLUSIONS
  Argyrosis can occur after long-term application of readily available eyelash tints, and the deposition of silver may be permanent. In certain circumstances, conjunctival argyrosis may simulate benign and malignant lesions, including conjunctival melanoma. These products should only be applied by trained cosmetologists.
authors.affiliation: Department of Ophthalmology, University of Texas Health Sciences Center, San Antonio, TX, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Gallardo
authors.forename: J Bradley
authors.initials: JB
authors.lastname: Randleman
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Price
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Johnson
authors.forename: Sharon
authors.initials: S
authors.lastname: Acosta
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
authors.forename: R Doyle
authors.initials: RD
authors.lastname: Stulting
mesh_terms: D000368:Aged; D001129:Argyria / Q000209:etiology* / Q000473:pathology; D003229:Conjunctival Diseases / Q000209:etiology* / Q000473:pathology; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D003886:Descemet Membrane / Q000187:drug effects; D005140:Eyelashes; D005141:Eyelid Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006202:Hair Dyes / Q000009:adverse effects*; D006801:Humans; D012646:Self Administration
chemical_list: D006202:Hair Dyes