title: Hereditary periodic fever syndrome sans fever or distinct periodicity presenting with psychosis.
abstract: The genetic basis for several hereditary periodic fever syndromes has been identified and consequently, the phenotypic spectrum of these disorders has broadened. We describe a young woman with tumor necrosis factor receptor-associated periodic syndrome (TRAPS), proven by mutational analysis, who presented with psychosis but without fever, symptom periodicity, or similar family medical history. This patient represents the first case of TRAPS-associated psychosis. This case illustrates the importance of mutation analysis for this group of disorders in individuals presenting with unexplained inflammatory symptoms and recurrent psychoses.
authors.affiliation: Department of Clinical Immunology, Auckland Hospital, New Zealand.
authors.forename: Miriam
authors.initials: M
authors.lastname: Hurst
authors.forename: Keith
authors.initials: K
authors.lastname: Hull
authors.forename: Dave
authors.initials: D
authors.lastname: Nicholls
authors.forename: Rohan
authors.initials: R
authors.lastname: Ameratunga
mesh_terms: D000293:Adolescent; D004247:DNA / Q000032:analysis; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D000068800:Etanercept; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D010507:Periodicity; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D007074:Immunoglobulin G; D007155:Immunologic Factors; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D011993:Recombinant Fusion Proteins; D004247:DNA; D000068800:Etanercept