The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.
Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.
Berra
Edurne
E
Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne, France.
Ginouvès
Amandine
A
Pouysségur
Jacques
J
D017398:Alternative Splicing; D000818:Animals; D005786:Gene Expression Regulation; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013379:Substrate Specificity; D014018:Tissue Distribution
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D011393:Procollagen-Proline Dioxygenase; D010100:Oxygen