Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis.
METHODS
Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes.


CONCLUSIONS
Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression-related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.
Rizkalla
Kamilia
K
Department of Pathology, University of Western Ontario, London, Ont.
Rodrigues
Sylvia
S
Proulx
Alain
A
Tingey
David P
DP
Heathcote
J Godfrey
JG
D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D015353:Eye Enucleation; D005260:Female; D013700:Giant Cell Arteritis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects*; D019572:Retinal Neoplasms / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor; D007166:Immunosuppressive Agents; D008727:Methotrexate