title: Portal vein embolization with N-butyl cyanoacrylate before partial hepatectomy in patients with hepatocellular carcinoma and underlying cirrhosis or advanced fibrosis.
abstract: OBJECTIVE
  To describe the safety, complications, and liver regeneration associated with the left liver after embolization of the right portal vein (PV) in patients with hepatocellular carcinoma (HCC) developed in the setting of advanced liver fibrosis and cirrhosis.
  
  
  METHODS
  Forty patients (31 men, nine women; mean age, 62 years) with HCC underwent PV embolization over a 4-year period. Embolization was performed from a left PV percutaneous access with use of n-butyl cyanoacrylate (NBCA) mixed with iodized oil. Computed tomography (CT) volumetry was performed before and 1 month after PV embolization to measure the left lobe volume as well as the functional liver ratio defined by the ratio between the left lobe and the total liver volume minus tumoral volume. PV pressure and liver enzyme levels were compared before and 1 month after the procedure and complications were registered. Factors potentially affecting regeneration (age, sex, diabetes, chemoembolization, functional liver ratio before PV embolization, and Knodell histologic score) were evaluated by one-way and stepwise regression analysis.
  
  
  RESULTS
  PV embolization could be achieved successfully in all cases. Two patients had partial PV thrombosis on the 1-month follow-up CT and two patients developed transient ascites after PV embolization. The left lobe volume increase was 41% +/- 32% after PV embolization and the functional liver ratio increased from 28% +/- 10% to 36% +/- 10% (P < .0001). Hypertrophy of the left lobe was greater in patients with a low functional liver ratio before PV embolization and those with an F3 fibrosis score. Other factors had no influence on left lobe regeneration.
  
  
  CONCLUSIONS
  PV embolization with use of NBCA is feasible in patients with advanced fibrosis and cirrhosis. Hypertrophy of the left lobe of the liver after PV embolization has a statistically significant correlation with lower functional liver ratio and lower degrees of fibrosis.
authors.affiliation: Department of Radiology and Interventional Radiology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. alban.denys@chuv.hospvd.ch
authors.forename: Alban
authors.initials: A
authors.lastname: Denys
authors.forename: Celine
authors.initials: C
authors.lastname: Lacombe
authors.forename: Frederic
authors.initials: F
authors.lastname: Schneider
authors.forename: David C
authors.initials: DC
authors.lastname: Madoff
authors.forename: Francesco
authors.initials: F
authors.lastname: Doenz
authors.forename: Salah D
authors.initials: SD
authors.lastname: Qanadli
authors.forename: Nermin
authors.initials: N
authors.lastname: Halkic
authors.forename: Alain
authors.initials: A
authors.lastname: Sauvanet
authors.forename: Valerie
authors.initials: V
authors.lastname: Vilgrain
authors.forename: Pierre
authors.initials: P
authors.lastname: Schnyder
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology / Q000628:therapy*; D003287:Contrast Media / Q000008:administration & dosage; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004621:Embolization, Therapeutic / Q000379:methods*; D004659:Enbucrilate; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D007459:Iodized Oil / Q000008:administration & dosage; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011169:Portal Vein / Q000000981:diagnostic imaging; D015641:Radiography, Interventional; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D003487:Cyanoacrylates; D007459:Iodized Oil; D004659:Enbucrilate