[Monozygous female twins discordant for a pattern of X chromosome inactivation as a model for study on X-linked intellectual traits].
Ring the last decades, numerous genes for general cognitive ability were identified on human X-chromosome. They were discovered primarily because of X-linked mutations causing nonspecific mental retardation in males. Evidence for imprinted loci on the X chromosome affecting neurodevelopment was found in studies on 45,X females. Investigation of transmission of X-linked traits in normal individuals might further contribute to problem of shaping human being's mind ability. We suggest monozygous female twins discordant for a parent-of-origin of the X chromosome inactivation to be a proper subject for such explorations.
Kovaleva
N V
NV
Ivanov
I A
IA
D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008957:Models, Genetic; D014430:Twins, Monozygotic / Q000235:genetics*; D049951:X Chromosome Inactivation / Q000235:genetics*