title: Two cases of retroperitoneal haematoma caused by interaction between antibiotics and warfarin.
abstract: Several commonly prescribed antibiotics are known to interact with warfarin, increasing its anticoagulant effect by different mechanisms. Retroperitoneal bleeding with consequent haematoma is recognised as a complication of over-anticoagulation. Consequences, which are potentially fatal, include hypovolaemic shock and compression of retroperitoneal structures such as the ureter and inferior vena cava.
authors.affiliation: Department of Surgery, Royal Surrey County Hospital, Egerton Road, Guildford, Surrey GU2 7XX, UK. drsimonphillips@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Phillips
authors.forename: A
authors.initials: A
authors.lastname: Barr
authors.forename: E
authors.initials: E
authors.lastname: Wilson
authors.forename: T A
authors.initials: TA
authors.lastname: Rockall
authors.forename: J F
authors.initials: JF
authors.lastname: Stebbing
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000925:Anticoagulants / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006406:Hematoma / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D012187:Retroperitoneal Space / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D014859:Warfarin