ChimerDB--a knowledgebase for fusion sequences.
Chromosome translocation and gene fusion are frequent events in the human genome and are often the cause of many types of tumor. ChimerDB is the database of fusion sequences encompassing bioinformatics analysis of mRNA and expressed sequence tag (EST) sequences in the GenBank, manual collection of literature data and integration with other known database such as OMIM. Our bioinformatics analysis identifies the fusion transcripts that have non-overlapping alignments at multiple genomic loci. Fusion events at exon-exon borders are selected to filter out the cloning artifacts in cDNA library preparation. The result is classified into two groups--genuine chromosome translocation and fusion between neighboring genes owing to intergenic splicing. We also integrated manually collected literature and OMIM data for chromosome translocation as an aid to assess the validity of each fusion event. The database is available at http://genome.ewha.ac.kr/ChimerDB/ for human, mouse and rat genomes.
Kim
Namshin
N
Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea.
Kim
Pora
P
Nam
Seungyoon
S
Shin
Seokmin
S
Lee
Sanghyuk
S
D000818:Animals; D030561:Databases, Nucleic Acid; D020224:Expressed Sequence Tags / Q000737:chemistry; D050939:Gene Fusion; D023281:Genomics; D006801:Humans; D020407:Internet; D051379:Mice; D050506:Mutant Chimeric Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000737:chemistry; D051381:Rats; D014584:User-Computer Interface
D050506:Mutant Chimeric Proteins; D012333:RNA, Messenger