Differential segmental growth of the vertebral column of the rat (Rattus norvegicus).
Despite the pervasive occurrence of segmental morphologies in the animal kingdom, the study of segmental growth is almost entirely lacking, but may have significant implications for understanding the development of these organisms. We investigate the segmental and regional growth of the entire vertebral column of the rat (Rattus norvegicus) by fitting a Gompertz curve to length and age data for each vertebra and each vertebral region. Regional lengths are calculated by summing constituent vertebral lengths and intervertebral space lengths for cervical, thoracic, lumbar, sacral, and caudal regions. Gompertz curves allow for the estimation of parameters representing neonatal and adult vertebral and regional lengths, as well as initial growth rate and the rate of exponential growth decay. Findings demonstrate differences between neonatal and adult rats in terms of relative vertebral lengths, and differential growth rates between sequential vertebrae and vertebral regions. Specifically, relative differences in the length of vertebrae indicate increasing differences caudad. Vertebral length in neonates increases from the atlas to the middle of the thoracic series and decreases in length caudad, while adult vertebral lengths tend to increase caudad. There is also a general trend of increasing vertebral and regional initial growth and rate of growth decay caudad. Anteroposterior patterns of growth are sexually dimorphic, with males having longer vertebrae than females at any given age. Differences are more pronounced (a) increasingly caudad along the body axis, and (b) in adulthood than in neonates. Elucidated patterns of growth are influenced by a combination of developmental, functional, and genetic factors.
Bergmann
Philip J
PJ
Vertebrate Morphology Research Group, Department of Biological Sciences, University of Calgary, Alta., Canada. pbergman@tulane.edu
Melin
Amanda D
AD
Russell
Anthony P
AP
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D008297:Male; D051381:Rats / Q000033:anatomy & histology* / Q000254:growth & development*; D012727:Sex Characteristics; D013131:Spine / Q000033:anatomy & histology* / Q000254:growth & development*