title: Serial angioscopic findings after successful intracoronary brachytherapy for in-stent restenosis.
abstract: The intracoronary changes that occur after brachytherapy for in-stent restenosis (ISR) have yet to be fully established. The purpose of this study in patients who had ISR was to examine the serial angioscopic changes in intracoronary lesions that occurred after brachytherapy. Forty-four patients who had ISR (49 lesions) underwent balloon angioplasty (n = 34) or directional atherectomy (n = 15), followed by intracoronary brachytherapy using a beta-emitting phosphorus-32 source wire. Angioscopic investigations were performed 3 and 9 months after brachytherapy. Uncovered stents were detected in 63.3% of lesions at 3 months. A significant decrease (p = 0.028) in this prevalence occurred over the next 6 months, with 36% of lesions having uncovered stents at 9 months. At 3 months, 33% of the lesions had visible erosion or ulceration and superficial thrombus. The prevalence of these characteristics was decreased at 9 months, although 17% of the lesions were still ulcerated or eroded at that time. Protruding thrombus was not observed in any lesion at 3 and 9 months. In conclusion, uncovered stents and intimal erosions or ulcerations were still present 9 months after brachytherapy in 36% and 17% of lesions, respectively. These results suggest that the healing process was not completed 9 months after brachytherapy in approximately 33% of lesions.
authors.affiliation: The Department of Cardiology, Shiga Medical Center for Adults, Shiga, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Okada
authors.forename: Hideo
authors.initials: H
authors.lastname: Tamai
authors.forename: Eisho
authors.initials: E
authors.lastname: Kyo
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kosuga
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Hata
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakamura
authors.forename: Shinya
authors.initials: S
authors.lastname: Fujita
authors.forename: Takafumi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Takeda
authors.forename: Nobutoyo
authors.initials: N
authors.lastname: Masunaga
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Motohara
authors.forename: Hiromu
authors.initials: H
authors.lastname: Uehata
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon; D017546:Angioscopy; D017225:Atherectomy, Coronary; D001918:Brachytherapy; D003324:Coronary Artery Disease / Q000473:pathology; D023903:Coronary Restenosis / Q000628:therapy*; D003328:Coronary Thrombosis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010761:Phosphorus Radioisotopes; D015607:Stents; D017539:Tunica Intima / Q000473:pathology
chemical_list: D010761:Phosphorus Radioisotopes