title: Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.
abstract: Histone deacetylases (HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and first-generation histone deacetylase inhibitors (HDACi) are currently being tested in phase I/II clinical trials. A wide-ranging knowledge of the role of HDACs in tumorigenesis, and of the action of HDACi, has been achieved. However, several basic aspects are not yet fully understood. Investigating these aspects in the context of what we now understand about HDACi action both in vitro and in vivo will further improve the design of optimized clinical protocols.
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, Via Ripamanti 435, 20141, Milan, Italy. saverio.minucci@ifom-ieo-campus.it
authors.forename: Saverio
authors.initials: S
authors.lastname: Minucci
authors.forename: Pier Giuseppe
authors.initials: PG
authors.lastname: Pelicci
mesh_terms: D044127:Epigenesis, Genetic; D051548:Histone Acetyltransferases / Q000502:physiology; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology / Q000628:therapy*
chemical_list: D056572:Histone Deacetylase Inhibitors; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases