Midazolam inhibits neophobia-induced Fos expression in the rat hippocampus.
The effect of midazolam on expression of c-Fos protein was examined in the rat hippocampus, following the open field test of neophobia. It was found that pretreatment of rats with midazolam, at the dose of 0.5 mg/kg, enhanced rat exploratory behavior, and inhibited neophobia related stimulation of c-Fos in the CA-1 and CA-3 areas of the hippocampus. The presented results provide new immunocytochemical data on the involvement of hippocampus in emotional processes related to neophobia, and indicate a possible site of action of benzodiazepines.
Wisłowska-Stanek
A
A
Department of Experimental and Clinical Pharmacology, Medical University, Warsaw, Poland.
Zienowicz
M
M
Lehner
M
M
Taracha
E
E
Bidziński
A
A
Maciejak
P
P
Skórzewska
A
A
Szyndler
J
J
Płaźnik
A
A
D000818:Animals; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008874:Midazolam / Q000494:pharmacology* / Q000627:therapeutic use; D010698:Phobic Disorders / Q000378:metabolism* / Q000517:prevention & control; D016760:Proto-Oncogene Proteins c-fos / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
D016760:Proto-Oncogene Proteins c-fos; D008874:Midazolam