title: [Prevalence of respiratory symptoms and diseases in neighbours of large-scale farming in Northern Germany].
abstract: BACKGROUND
  Up to now potential health effects of environmental exposure to intensive livestock production facilities have not been thoroughly studied. The aim of the Lower Saxony Lung Study (NiLS) was to assess the prevalence of respiratory symptoms and disease in an area with intensive animal production facilities taking into account environmental exposure to emissions from these large-scale farms.
  
  
  METHODS
  All 10 864 inhabitants (age 18 to 44 years) of four towns with a large number of intensive animal production facilities in the area were invited to answer a mail-in questionnaire. Of these, 6416 subjects were randomly selected for the clinical part of the study (specific IgE, lung function measurements, bronchial provocation with methacholine). Overall, 6937 subjects answered the questionnaire (68 %), 60 % took part in the clinical tests.
  
  
  RESULTS
  The prevalence of allergic disease in the study population was lower than in urban citizens. Subjects with more than 12 animal houses within 500 m of their home had an increased odds ratio for wheezing without a cold (odds ratio 2.7; 95 % confidence interval 1.4 - 5.4). They also showed a significantly decreased FEV (1) (mean 0.26 l; 0.04 l - 0.48 l) as well as a trend for a lower Tiffeneau-Index.
  
  
  CONCLUSIONS
  In result, a large number of intensive animal production facilities might be associated with decreased lung function results in the immediate neighbours. Further studies are necessary to confirm our findings.
authors.affiliation: Arbeitsgruppe Arbeits- und Umweltepidemiologie and NetTeaching, Institut und Poliklinik für Arbeits- und Umweltmedizin der Ludwig-Maximilians-Universität München. katja.radon@med.uni-muenchen.de
authors.forename: K
authors.initials: K
authors.lastname: Radon
authors.forename: A
authors.initials: A
authors.lastname: Schulze
authors.forename: R van
authors.initials: Rv
authors.lastname: Strien
authors.forename: V
authors.initials: V
authors.lastname: Ehrenstein
authors.forename: G
authors.initials: G
authors.lastname: Praml
authors.forename: D
authors.initials: D
authors.lastname: Nowak
mesh_terms: D000293:Adolescent; D000328:Adult; D000383:Agriculture; D000818:Animals; D005858:Germany / Q000453:epidemiology; D006799:Housing, Animal; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D015995:Prevalence; D012140:Respiratory Tract Diseases / Q000453:epidemiology*; D012424:Rural Population; D014505:Urban Population