title: Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters.
abstract: This is the first report on proteomic analysis of the cerebrospinal fluid (CSF) in unmedicated suicide attempters and non-attempters with major depressive disorder. Two-dimensional (2D) gel electrophoresis revealed that suicide attempters differed from non-attempters in one protein with an approximate molecular weight of 33 kD and an isoelectric point of 5.2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research.
authors.affiliation: Facharzt für Psychiatrie und Psychotherapie, Munich, Germany. jkbrunnr@gmx.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Brunner
authors.forename: Thomas
authors.initials: T
authors.lastname: Bronisch
authors.forename: Manfred
authors.initials: M
authors.lastname: Uhr
authors.forename: Marcus
authors.initials: M
authors.lastname: Ising
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Binder
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
authors.forename: Christoph W
authors.initials: CW
authors.lastname: Turck
mesh_terms: D000328:Adult; D002556:Cerebrospinal Fluid Proteins / Q000737:chemistry*; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid* / Q000523:psychology*; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D040901:Proteomics; D011569:Psychiatric Status Rating Scales; D013406:Suicide, Attempted / Q000523:psychology*
chemical_list: D002556:Cerebrospinal Fluid Proteins