title: Circulating leptin, zinc, and copper levels after extracorporeal circulation.
abstract: OBJECTIVE
  The role of leptin in the acute stress response to extracorporeal circulation has been well documented, however, the relationship between leptin and zinc has not been investigated previously. We aimed to research the circulating leptin, zinc, and copper levels before, during, and after the extracorporeal circulation, and effect of preoperative zinc administration to these.
  
  
  METHODS
  Twenty patients who were taken to elective coronary artery bypass grafting operations using extracorporeal circulation were taken to this research and divided into two equal groups (n1, n2). In both groups blood samples were taken just before the operation (T0), at the end of operation (T1), and at the first postoperative day (T2). In the second group (n2) oral zinc (50 mg, once a day) was administered to patients for 5 days, preoperatively. The serum leptin, zinc, and copper levels were studied.
  
  
  RESULTS
  In group n1 circulating leptin levels were significantly increased at T2 when compared to T0 and T1 (p<0.05); zinc levels were decreased at T2 when compared to T0 and T1 (p<0.05); copper levels were decreased at T2 when compared to T0 (p<0.05), and decreased at T1 when compared to T0 (p<0.05). In group n2 circulating leptin levels were significantly increased at T2 when compared to T0 and T1 (p<0.05); zinc levels were decreased at T2 when compared to T0 and T1 (p<0.05); copper levels were increased at T2 when compared to T1 (p<0.05).
  
  
  CONCLUSIONS
  These results indicate that circulating leptin levels increase after the extracorporeal circulation as an acute response, while zinc and copper levels decrease at the same period. Preoperative zinc administration does not prevent the leptin response after extracorporeal circulation.
authors.affiliation: Department of Physiology, Meram Medical School, Selcuk University, Konya, Turkey.
authors.forename: Zulfikare Isik
authors.initials: ZI
authors.lastname: Gormus
authors.forename: Niyazi
authors.initials: N
authors.lastname: Gormus
authors.forename: Abdulkerim Kasim
authors.initials: AK
authors.lastname: Baltaci
authors.forename: Ihsan
authors.initials: I
authors.lastname: Halifeoglu
authors.forename: Rasim
authors.initials: R
authors.lastname: Mogulkoc
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage; D003300:Copper / Q000097:blood*; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D020738:Leptin / Q000097:blood*; D011300:Preoperative Care; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology* / Q000517:prevention & control; D015032:Zinc / Q000008:administration & dosage / Q000097:blood*
chemical_list: D000975:Antioxidants; D020738:Leptin; D003300:Copper; D015032:Zinc