title: Enantioseparation of acidic enantiomers in capillary electrophoresis using a novel single-isomer of positively charged beta-cyclodextrin: Mono-6A-N-pentylammonium-6A-deoxy- beta-cyclodextrin chloride.
abstract: The new single-isomer of positively charged beta-cyclodextrin, mono-6A-N-pentylammonium-6A-deoxy-beta-cyclodextrin chloride (PeAM-beta-CD), was employed for the first time for the enantioseparation of anionic and ampholytic analytes by capillary electrophoresis (CE). The synthesis and characterization of PeAM-beta-CD were reported. The effect of background electrolyte (BGE) pH and selector concentration on the enantioseparation was investigated. Good separation was obtained at low BGE pH (ca. 5.0-6.0). The effective mobilities of all analytes were found to decrease with increasing CD concentration. PeAM-beta-CD proved to be an effective chiral selector for most studied anionic analytes.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
authors.forename: Weihua
authors.initials: W
authors.lastname: Tang
authors.forename: Wayan
authors.initials: W
authors.lastname: Muderawanb
authors.forename: Teng-Teng
authors.initials: TT
authors.lastname: Ong
authors.forename: Siu-Choon
authors.initials: SC
authors.lastname: Ng
mesh_terms: D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D006880:Hydroxy Acids / Q000737:chemistry; D007536:Isomerism; D055672:Static Electricity; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D006880:Hydroxy Acids; D047392:beta-Cyclodextrins; C507648:mono-6A-N-pentylammonium-6A-deoxy- beta-cyclodextrin chloride