title: Ultrahigh resolution optical coherence tomography in macular dystrophy.
abstract: OBJECTIVE
  To visualize and investigate intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR OCT).
  
  
  METHODS
  Prospective observational case series.
  
  
  METHODS
  setting: Department of Ophthalmology and Center for Biomedical Engineering and Physics, Christian Doppler Laboratory, Medical University of Vienna, Vienna, Austria. patients: Thirteen patients (23 eyes) with adult-onset foveomacular vitelliform dystrophy (AOFVD) and 14 patients (27 eyes) with Stargardt's disease (SD) or fundus flavimaculatus (FF).
  
  
  METHODS
  Imaging using a compact, new generation UHR OCT system, achieving considerably improved visualization of intraretinal layers, especially the photoreceptor layer. main outcome measures: UHR OCT tomograms visualizing intraretinal differences in morphology of AOFVD and SD/FF as location and extension of deposits and loss of photoreceptors. Central foveal thickness defined as distance between internal limiting membrane and photoreceptors/retinal pigment epithelium interface.
  
  
  RESULTS
  Patients with AOFVD had a mostly intact photoreceptor layer, a central foveal thickness of 142 +/- 23 microm as well as subretinal deposits. Patients with SD generally had a diffuse degenerative change with a visible reduction in thickness of all intraretinal layers, resulting in a corresponding reduction of central foveal thickness (94 +/- 38 microm) and central loss of photoreceptors (PRs). Comparative central foveal thickness of patients with AOFVD and SD/FF was significantly different (P < .001). Patients with FF had pigment epithelial deposits and paracentral focal photoreceptor loss.
  
  
  CONCLUSIONS
  UHR OCT is a clinically feasible tool for examining intraretinal changes, in particular photoreceptor atrophy in macular dystrophies and, therefore, has the potential to be an adequate imaging system for monitoring the course of disease.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Währinger Strasse 13, 1090 Vienna, Austria.
authors.forename: Matthias G
authors.initials: MG
authors.lastname: Wirtitsch
authors.forename: Erdem
authors.initials: E
authors.lastname: Ergun
authors.forename: Boris
authors.initials: B
authors.lastname: Hermann
authors.forename: Angelika
authors.initials: A
authors.lastname: Unterhuber
authors.forename: Michael
authors.initials: M
authors.lastname: Stur
authors.forename: Christoph
authors.initials: C
authors.lastname: Scholda
authors.forename: Harald
authors.initials: H
authors.lastname: Sattmann
authors.forename: Tony H
authors.initials: TH
authors.lastname: Ko
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Drexler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*