Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma.
Inhaled corticosteroids suppress airway inflammation and components of airway remodelling in bronchial asthma. In the tracheobronchial (airway) vasculature, these include the inhibition of inflammatory hyperperfusion, microvascular hyperpermeability, mucosal oedema formation, and the formation of new blood vessels (angiogenesis). Corticosteroids are now known to exert their effects on the airway vasculature through genomic and nongenomic mechanisms. Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. In contrast, nongenomic actions are mediated by rapid cellular mechanisms, and induce transient vasoconstriction in the airway, thereby reversing inflammatory hyperperfusion. The vascular actions of corticosteroids contribute to controlling clinical symptoms of asthma primarily by influencing airway calibre in the lung periphery and airway hyperreactivity. In this review article, recent advances into the understanding of cellular mechanisms and the clinical implications of the interaction of inhaled corticosteroids and the airway vasculature in asthma are reviewed.
Horvath
G
G
Division of Pulmonary and Critical Care Medicine, University of Miami School of Medicine, Miami, FL 33101, USA.
Wanner
A
A
D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000235:genetics; D000402:Airway Obstruction / Q000503:physiopathology; D000403:Airway Resistance / Q000187:drug effects / Q000235:genetics; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D001783:Blood Flow Velocity; D001980:Bronchi / Q000098:blood supply* / Q000187:drug effects; D016084:Bronchoconstriction / Q000187:drug effects; D016678:Genome; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D018919:Neovascularization, Physiologic / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D000305:Adrenal Cortex Hormones