title: Rosai-Dorfman syndrome.
abstract: Rosai-Dorfman syndrome is characterized by sinus histiocytosis with massive lymphadenopathy. A 25-year-old woman presented with multiple erythematous and yellowish papules on the forehead, cheeks, chin and thigh. She had massive generalized, firm, non-tender and non-matted lymphadenopathy and mild hepatomegaly. Her hemogram was normal. A skin biopsy showed collections of histiocytes with emperipolesis and plenty of plasma cells. A lymph node biopsy showed partial loss of architecture, dilated sinuses filled with histiocytes, which showed lymphocytophagocytosis, anisonucleosis and a clear cytoplasm. She was referred to an oncologist for further management.
authors.affiliation: Department of Dermatology, Medical College, Calicut, India. saif_gem@hotmail.com
authors.forename: Najeeba
authors.initials: N
authors.lastname: Riyaz
authors.forename: Anza
authors.initials: A
authors.lastname: Khader
authors.forename: S
authors.initials: S
authors.lastname: Sarita
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006529:Hepatomegaly / Q000175:diagnosis; D015618:Histiocytosis, Sinus / Q000175:diagnosis*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D012867:Skin / Q000473:pathology