title: The effect of oral appliance therapy on blood pressure in patients with obstructive sleep apnea.
abstract: The objective of the study was to investigate the effects of oral appliance (OA) therapy on ambulatory blood pressure in patients with obstructive sleep apnea (OSA). Eleven OSA patients who received OA therapy were prospectively investigated. Ambulatory blood pressure was measured for 20 h from 4:00 P.M.: to 12:00 noon the next day using an ambulatory blood pressure monitor. The Respiratory Disturbance Index (RDI) was measured in the pretreatment and posttitration periods. The OA was titrated to reach a therapeutic jaw position over 2 to 8 months, and posttitration measurements were repeated. At posttitration, the RDI was significantly decreased from a mean (SD) of 24.7 (20.1) to 6.1 (4.5). Significant reductions in diastolic blood pressure (DBP) and mean arterial pressure (MAP) were found for the 20-h periods, and systolic blood pressure (SBP), DBP, and MAP while asleep. The mean values were 79.5 (5.5) to 74.6 (6.0) for DBP and 95.9 (5.4) to 91.2 (5.9) for MAP, for over a 20-h period, and 118.4 (10.0) to 113.7 (9.1) for SBP, 71.6 (8.0) to 67.2 (7.9) for DBP, and 88.4 (8.0) to 83.9 (7.5) for MAP, while asleep. This study suggests that successful OSA treatment with an OA may also be beneficial to lower blood pressure in OSA patients, as previously suggested for nasal continuous positive airway pressure therapy.
authors.affiliation: Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, Canada. r-otsuka@mx2.nisiq.net
authors.forename: Ryo
authors.initials: R
authors.lastname: Otsuka
authors.forename: Fernanda
authors.initials: F
authors.lastname: Ribeiro de Almeida
authors.forename: Alan A
authors.initials: AA
authors.lastname: Lowe
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Linden
authors.forename: Frank
authors.initials: F
authors.lastname: Ryan
mesh_terms: D000202:Activator Appliances; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D015992:Body Mass Index; D005260:Female; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008334:Mandible / Q000502:physiology; D008875:Middle Aged; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000453:epidemiology; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000628:therapy*
chemical_list: D000959:Antihypertensive Agents