title: DBTSS: DataBase of Human Transcription Start Sites, progress report 2006.
abstract: DBTSS was first constructed in 2002 based on precise, experimentally determined 5' end clones. Several major updates and additions have been made since the last report. First, the number of human clones has drastically increased, going from 190,964 to 1,359,000. Second, information about potential alternative promoters is presented because the number of 5' end clones is now sufficient to determine several promoters for one gene. Namely, we defined putative promoter groups by clustering transcription start sites (TSSs) separated by <500 bases. A total of 8308 human genes and 4276 mouse genes were found to have putative multiple promoters. Third, DBTSS provides detailed sequence comparisons of user-specified TSSs. Finally, we have added TSS information for zebrafish, malaria and schyzon (a red algae model organism). DBTSS is accessible at http://dbtss.hgc.jp.
authors.affiliation: Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Riu
authors.initials: R
authors.lastname: Yamashita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Wakaguri
authors.forename: Katsuki
authors.initials: K
authors.lastname: Tsuritani
authors.forename: Kenta
authors.initials: K
authors.lastname: Nakai
authors.forename: Sumio
authors.initials: S
authors.lastname: Sugano
mesh_terms: D000818:Animals; D030561:Databases, Nucleic Acid / Q000706:statistics & numerical data; D006801:Humans; D020407:Internet; D051379:Mice; D010963:Plasmodium falciparum / Q000235:genetics; D011401:Promoter Regions, Genetic; D000461:Rhodophyta / Q000235:genetics; D024363:Transcription Initiation Site; D015027:Zebrafish / Q000235:genetics