title: Adverse effects of EMLA (lidocaine/prilocaine) cream and efficacy for the placement of jugular catheters in hospitalized cats.
abstract: EMLA is a lidocaine/prilocaine cream used for topical analgesia in human pediatric patients. The purpose of this study was to establish the safety of EMLA in clinically ill cats, to measure systemic absorption and to determine whether EMLA reduced the need for sedation for the placement of jugular catheters. Thirty-one cats were randomized to either a placebo or EMLA cream group. Cream was applied to a 10 cm(2) area over the jugular vein, with 1h of occlusive dressing. Neither anesthetic was systemically absorbed in any cat, and no adverse clinical signs were observed. Struggling during catheter placement was less in the EMLA-treated cats compared to placebo, but did not reach significance (P = 0.06). Jugular catheters were successfully placed in 60% of EMLA-treated cats and 38% of placebo cats; this difference was not statistically significant and may not justify the added steps of EMLA cream administration for this purpose. However, EMLA does appear to be safe in clinically ill cats, and may be useful for other applications such as for skin mass removal or repeated venepuncture.
authors.affiliation: Department of Medical Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, 53706-1102, USA.
authors.forename: Karin A
authors.initials: KA
authors.lastname: Wagner
authors.forename: Kristi J
authors.initials: KJ
authors.lastname: Gibbon
authors.forename: Tami L
authors.initials: TL
authors.lastname: Strom
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Kurian
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Trepanier
mesh_terms: D000698:Analgesia / Q000379:methods / Q000662:veterinary*; D019162:Anesthetics, Combined / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000662:veterinary*; D002415:Cats; D005260:Female; D007601:Jugular Veins; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D009824:Ointments / Q000008:administration & dosage / Q000009:adverse effects*; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary; D011318:Prilocaine / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine