title: Gene regulation by histone H1: new links to DNA methylation.
abstract: Linker histones of the H1 family are among the most abundant components of chromatin. In this issue of Cell, the effect of H1 downregulation on gene expression is examined. Although a 50% reduction of histone H1 levels in embryonic stem cells affects chromatin structure globally, the expression of very few genes is altered. Intriguingly, this study reveals a new link between H1 and DNA methylation.
authors.affiliation: Adolf-Butenandt-Institut, Molekularbiologie, Schillerstr. 44 . 80336 München, Germany.
authors.forename: Ralph A W
authors.initials: RA
authors.lastname: Rupp
authors.forename: Peter B
authors.initials: PB
authors.lastname: Becker
mesh_terms: D000818:Animals; D019175:DNA Methylation; D005786:Gene Expression Regulation / Q000502:physiology*; D006657:Histones / Q000502:physiology*; D006801:Humans
chemical_list: D006657:Histones