Playing ping pong with pins: cortical and microtubule-induced polarity.
Cortical cell polarity controls mitotic spindle orientation in many cell types. In this issue of Cell, it is turned around and shown that the transfer of polarity information between the cortex and the spindle is not just one way. In Drosophila neuroblasts, the spindle also has polarizing activity on the cortex.
Ahringer
Julie
J
The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom. jaa@mole.bio.cam.ac.uk
D000818:Animals; D018797:Cell Cycle Proteins; D016764:Cell Polarity / Q000502:physiology*; D004330:Drosophila; D029721:Drosophila Proteins / Q000502:physiology*; D020730:Guanine Nucleotide Dissociation Inhibitors / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D020730:Guanine Nucleotide Dissociation Inhibitors; C405164:Pins protein, Drosophila