A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremor.
The authors performed an open-label, rater-blinded, add-on study of sodium oxybate in 20 patients with ethanol-responsive myoclonus or essential tremor. Blinded ratings of videotaped examinations showed improvements in myoclonus at rest, stimulus-sensitive myoclonus, action myoclonus, functional performance, and postural and kinetic tremor. Tolerability was acceptable, and more than half of the patients chose to continue treatment after the trial. Double-blind placebo-controlled studies in these disorders are warranted.
Frucht
S J
SJ
Columbia University Medical Center, New York, USA. sf216@columbia.edu
Houghton
W C
WC
Bordelon
Y
Y
Greene
P E
PE
Louis
E D
ED
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000009:adverse effects; D000328:Adult; D000342:Affective Symptoms / Q000139:chemically induced; D000368:Aged; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004244:Dizziness / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D020329:Essential Tremor / Q000188:drug therapy*; D000431:Ethanol / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000188:drug therapy*; D009325:Nausea / Q000139:chemically induced; D010349:Patient Compliance; D010352:Patient Dropouts / Q000706:statistics & numerical data; D012978:Sodium Oxybate / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
D000759:Adjuvants, Anesthesia; D000431:Ethanol; D012978:Sodium Oxybate