Role of macrophage migration inhibitory factor in paranasal sinus mucocele.
BACKGROUND
Little is known about the immunologic aspects and the pathogenesis of the paranasal sinus mucocele.


METHODS
The fluids of paranasal sinus mucoceles were obtained from 12 subjects. The concentration of macrophage migration inhibitory factor (MIF), interleukin 1beta, tumor necrosis factor alpha, and regulated on activation normal T cell expressed and secreted (RANTES) were determined by enzyme-linked immunosorbent assay, and the levels of endotoxin were detected with kinetic Turbidimetric Assay.


RESULTS
MIF and endotoxin were detected in the fluid of all samples, whereas interleukin-1beta and RANTES were detected in 1 and 3 subjects out of 12 samples. Tumor necrosis factor alpha was not detected in any of the samples. A significant positive correlation between the levels of MIF and the period with symptoms such as pain, swelling of face, and visual disturbance was observed.


CONCLUSIONS
These findings suggest that MIF and endotoxin may play an important role in the pathogenesis of paranasal sinus mucocele. MIF may be an important factor causing the development and exacerbation of the disease.
Kariya
Shin
S
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan.
Okano
Mitsuhiro
M
Aoji
Katsuya
K
Nakashima
Tomoko
T
Kasai
Norio
N
Onoda
Tomoo
T
Nishizaki
Kazunori
K
Schachern
Patricia A
PA
Cureoglu
Sebahattin
S
Paparella
Michael M
MM
D000368:Aged; D000369:Aged, 80 and over; D018946:Chemokine CCL5 / Q000032:analysis; D004731:Endotoxins / Q000032:analysis; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009078:Mucocele / Q000276:immunology*; D010254:Paranasal Sinus Diseases / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D018946:Chemokine CCL5; D004731:Endotoxins; D007375:Interleukin-1; D008263:Macrophage Migration-Inhibitory Factors; D014409:Tumor Necrosis Factor-alpha