Coupled dynamics of RNA folding and nanopore translocation.
The translocation of structured RNA or DNA molecules through narrow pores necessitates the opening of all base pairs. Here, we study the interplay between the dynamics of translocation and base pairing theoretically, using kinetic Monte Carlo simulations and analytical methods. We find that the transient formation of base pairs that do not occur in the ground state can significantly speed up translocation.
Bundschuh
Ralf
R
Department of Physics, The Ohio State University, Columbus, Ohio 43210-1117, USA.
Gerland
Ulrich
U
D020029:Base Pairing; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological; D009010:Monte Carlo Method; D049329:Nanostructures; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D034443:RNA Transport; D012330:RNA, Double-Stranded / Q000737:chemistry
D012330:RNA, Double-Stranded; D012313:RNA