title: Subarachnoid hemorrhage associated with von Willebrand's disease--case report.
abstract: A 59-year-old woman with type IIA von Willebrand's disease (VWD) presented with subarachnoid hemorrhage (SAH). Computed tomography showed SAH in the right sylvian fissure and intracranial hemorrhage in the right temporal lobe. Angiography demonstrated an aneurysm at the bifurcation of the right middle cerebral artery. Neck clipping was performed on the 3rd day after the onset with intra- and postoperative administration of factor VIII/von Willebrand factor concentrate. No excessive bleeding occurred. Patients with prolonged bleeding time should be screened for VWD before surgery. This is a rare case of VWD presenting with SAH secondary to ruptured intracranial aneurysm. The clinical characteristics and the management of SAH in a patient with VWD are discussed.
authors.affiliation: Department of Neurosurgery, Kanazawa University School of Medicine, Ishikawa. reiko.nakau.@ujitoku.or.jp
authors.forename: Reiko
authors.initials: R
authors.lastname: Nakau
authors.forename: Motohiro
authors.initials: M
authors.lastname: Nomura
authors.forename: Shinya
authors.initials: S
authors.lastname: Kida
authors.forename: Junkoh
authors.initials: J
authors.lastname: Yamashita
authors.forename: Akira
authors.initials: A
authors.lastname: Kinoshita
authors.forename: Hisashi
authors.initials: H
authors.lastname: Nitta
authors.forename: Naoki
authors.initials: N
authors.lastname: Muramatsu
mesh_terms: D017542:Aneurysm, Ruptured / Q000150:complications*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000209:etiology*; D014842:von Willebrand Diseases / Q000150:complications*