title: Rickettsial infections around the world, part 1: pathophysiology and the spotted fever group.
abstract: BACKGROUND
  The rickettsial diseases are an important group of infectious agents that have dermatological manifestations. These diseases are important to consider in endemic areas, but in certain suspicious cases, possible acts of bioterrorism should warrant prompt notification of the appropriate authorities.
  
  
  OBJECTIVE
  In this two part review article, we review these diverse diseases by examining established and up-to-date information about the pathophysiology, epidemiology, clinical manifestations, and treatment of the ricksettsiae.
  
  
  METHODS
  Using PubMed to search for relevant articles, we browsed over 500 articles to compose a clinically based review article.
  
  
  RESULTS
  Part one focuses on pathophysiology of the rickettsial diseases and the clinical aspects of the spotted fever group.
  
  
  CONCLUSIONS
  At the completion of part one of this learning activity, participants should be able to discuss all of the clinical manifestations and treatments of the sported fever group. Participants should also be familiar with the pathophysiology of the rickettsial diseases.
authors.affiliation: Department of Dermatology, University of California, Irvine, California, USA.
authors.forename: Jashin J
authors.initials: JJ
authors.lastname: Wu
authors.forename: David B
authors.initials: DB
authors.lastname: Huang
authors.forename: Katie R
authors.initials: KR
authors.lastname: Pang
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Tyring
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001907:Boutonneuse Fever / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D003937:Diagnosis, Differential; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D007303:Insect Vectors; D011379:Prognosis; D013752:Tetracycline / Q000627:therapeutic use; D013987:Ticks
chemical_list: D000900:Anti-Bacterial Agents; D013752:Tetracycline; D004318:Doxycycline