Total synthesis of UCS1025A.
The enantioselective total synthesis of the telomerase inhibitor UCS1025A has been accomplished. The key transformation involves a remarkable boron Reformatsky coupling of iodolactone 13 and aldehyde 17.
Lambert
Tristan H
TH
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.
Danishefsky
Samuel J
SJ
D000164:Acremonium / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis*; D019098:Telomerase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011763:Pyrrolizidine Alkaloids; C409195:UCS 1025A; D019098:Telomerase