Protein recognition via surface molecularly imprinted polymer nanowires.
In this paper, we present a technique for the preparation of polymer nanowires with the protein molecule imprinted and binding sites at surface. These surface imprinting nanowires exhibit highly selective recognition for a variety of template proteins, including albumin, hemoglobin, and cytochrome c. This recognition may be through a multistep adsorption, with the specificity conferred by hydrogen bonding and shape selectivity. Due to the protein imprinted sites are located at, or close to, the surface; these imprinted nanowires have a good site accessibility toward the target protein molecules. Furthermore, the large surface area of the nanowires results in large protein molecule binding capacity of the imprinted nanowires.
Li
Yong
Y
The First Institute of Oceanography, SOA, Qingdao, 266061, PR China.
Yang
Huang-Hao
HH
You
Qi-Hua
QH
Zhuang
Zhi-Xia
ZX
Wang
Xiao-Ru
XR
D000327:Adsorption; D000538:Aluminum Silicates; D000818:Animals; D001672:Biocompatible Materials; D006801:Humans; D006860:Hydrogen Bonding; D011108:Polymers / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D013499:Surface Properties
D000538:Aluminum Silicates; D001672:Biocompatible Materials; D011108:Polymers; D011506:Proteins