title: Total IgE levels do not change 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis.
abstract: BACKGROUND
  Total IgE levels positively correlate with the amount of mucosal thickening on sinus CT scans. Our objective was to investigate whether the levels of total serum IgE decreased 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis, suggesting that the total IgE was influenced by the sinus disease.
  
  
  METHODS
  55 patients about to undergo endoscopic sinus surgery for chronic rhinosinusitis were enrolled in a prospective clinical study. All patients had preoperative sinus computerized tomography (CT) scans and levels of total serum IgE measured before surgery and 1 year postoperatively.
  
  
  RESULTS
  Preoperative total IgE levels showed a significant correlation with the extent of disease on sinus CT (r(s) = 0.413, p = 0.002). Total serum IgE levels did not show any statistically significant change from the preoperative values when measured 1 year postoperatively (324.25 +/- 217.30 ng/ml vs. 326.35 +/- 204.50 ng/ml; p = 0.61).
  
  
  CONCLUSIONS
  The levels of total serum IgE do not change after sinus surgery for chronic rhinosinusitis. IgE levels in chronic rhinosinusitis may reflect a systemic factor in disease pathogenesis, and are probably not related to the amount of local inflammation within the sinuses.
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, IL 60637, USA.
authors.forename: Devyani
authors.initials: D
authors.lastname: Lal
authors.forename: Fuad M
authors.initials: FM
authors.lastname: Baroody
authors.forename: Eric K
authors.initials: EK
authors.lastname: Weitzel
authors.forename: Marcy
authors.initials: M
authors.lastname: deTineo
authors.forename: Robert M
authors.initials: RM
authors.lastname: Naclerio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000601:surgery*; D012220:Rhinitis / Q000276:immunology / Q000601:surgery*; D012852:Sinusitis / Q000276:immunology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D007073:Immunoglobulin E