Unexpected roles for deacetylation in interferon- and cytokine-induced transcription.
Protein acetylation is a reversible modification that has been implicated in epigenetic regulation of gene expression. It is widely accepted that acetylation enzymes are present at transcriptionally active promoters and deacetylation enzymes associate with transcriptionally silent loci. These results notwithstanding, recent findings indicate that positive regulation of gene expression by interferons and other cytokines requires both acetylation and deacetylation.
Nusinzon
Inna
I
Department of Medicine Northwestern University, 2200 Campus Drive, Evanston, IL 60208, USA. Inna-Nusinzon@northwestern.edu
Horvath
Curt M
CM
D000107:Acetylation; D000818:Animals; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D051548:Histone Acetyltransferases / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
D016207:Cytokines; D007372:Interferons; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases