The effects of acetylsalicylic acid on the pituitary prolactin of the lizard, Uromastix hardwickii.
This study deals with the intravenous administration of 7 mg acetylsalicylic acid (ASA) solution to Uromastix hardwickii for 4 days. It enhances the activity of anterior pituitary lactotrophs, when 0.1 ml of pituitary homogenate of ASA treated was injected hypodermically to crop-sac showed a greater diametric response and increased activity with milk like secretion than that of the injections of 0.1 ml homogenate of control pituitary. The present study indicated that ASA induces hyperprolactinemia.
Ahmad
Mahmood
M
Department of Physiology, University of Karachi, Karachi-75270, Pakistan.
Hasan
Ruqaiya
R
Ahmad
Mansoor
M
Qureshi
Anila
A
Masroor
Shama
S
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D008116:Lizards; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D011453:Prostaglandins / Q000502:physiology
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011388:Prolactin; D001241:Aspirin