Synthetic approaches to the 2004 new drugs.
New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. In addition, these new chemical entities (NCEs) not only provide insights into molecular recognition, but also serve as leads for designing future drugs. To this end, this review covers the syntheses of 12 NCEs marketed in 2004.
Li
Jin
J
Pfizer Global Research and Development, Pfizer Inc, Groton CT 06340, USA. jin.li@pfizer.com
Liu
Kevin K-C
KK
Sakya
Subas
S
D017277:Drug Approval; D015195:Drug Design; D006801:Humans; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D014481:United States; D014486:United States Food and Drug Administration
D004364:Pharmaceutical Preparations