Acetogenins in Annona muricata L. (annonaceae) leaves are potent molluscicides.
An ethanolic extract of the leaves of Annona muricata was shown to be toxic to adult forms of the snail Biomphalaria glabrata (LC50 9.32 microg mL(-1)) and to larvae of the brine shrimp Artemia salina (LC50 0.49 microg mL(-1)). Activity-guided fractionation of the extract gave rise to a sample with high molluscicidal activity that contained the acetogenins, annonacin (90%), isoannonacin (6%) and goniothalamicin (4%).
Luna
J De S
Jde S
Departamento de Química Fundamental, Universidade Federal de Pernambuco, 50.740-901 Recife-PE, Brazil.
De Carvalho
J M
JM
De Lima
M R F
MR
Bieber
L W
LW
Bento
Edson De S
Ede S
Franck
X
X
Sant'ana
A E G
AE
D054378:Acetogenins; D000818:Animals; D031041:Annona / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008974:Mollusca / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry*
D054378:Acetogenins; D005233:Fatty Alcohols; D007783:Lactones