Dinuclear Zn-catalyzed asymmetric alkynylation of unsaturated aldehydes.
Our recent development of a proline-derived bimetallic catalyst has led to a number of efficient, catalytic, enantioselective transformations. Herein, we report a practical and general alkynylation of aromatic and alpha,beta-unsaturated aldehydes using our zinc catalyst system.
Trost
Barry M
BM
Department of Chemistry, Stanford University, Stanford, CA 94305-8080, USA. bmtrost@stanford.edu
Weiss
Andrew H
AH
von Wangelin
Axel Jacobi
AJ
D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000138:chemical synthesis*; D002384:Catalysis; D011392:Proline / Q000031:analogs & derivatives; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
D000447:Aldehydes; D000475:Alkenes; D000480:Alkynes; D011392:Proline; D015032:Zinc