title: Lack of CD27 in myeloma delineates different presentation and outcome.
abstract: CD27 expression was evaluated on normal plasma cells (PC), PC from patients with multiple myeloma (MM) at diagnosis or relapse and on human myeloma cell lines (HMCL). CD27 was expressed by normal PC but was lacking in PC from MM patients at diagnosis (36%) and relapse (47%), and in HMCL (92%). The prognostic impact of CD27 expression was evaluated in 42 patients with de novo MM. Overall survival was 92% at 3 years in CD27(+) vs. 50% in CD27(-) MM (P = 0.017). CD27 expression seems to delineate two important subsets of MM with different presenting features and clinical outcomes.
authors.affiliation: Department of Clinical Haematology, Hôtel Dieu, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.forename: Nelly
authors.initials: N
authors.lastname: Robillard
authors.forename: Gaétan
authors.initials: G
authors.lastname: Jégo
authors.forename: Catherine
authors.initials: C
authors.lastname: Pellat
authors.forename: Steven
authors.initials: S
authors.lastname: Le Gouill
authors.forename: Soraya
authors.initials: S
authors.lastname: Thoumi
authors.forename: Hervé
authors.initials: H
authors.lastname: Avet-Loiseau
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Harousseau
authors.forename: Régis
authors.initials: R
authors.lastname: Bataille
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000628:therapy; D010950:Plasma Cells / Q000276:immunology; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000097:blood*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7