title: Locally generated particulate pollution and respiratory symptoms in young children.
abstract: BACKGROUND
  Particulate matter <10 mum (PM(10)) from fossil fuel combustion is associated with an increased prevalence of respiratory symptoms in children and adolescents. However, the effect of PM(10) on respiratory symptoms in young children is unclear.
  
  
  METHODS
  The association between primary PM(10) (particles directly emitted from local sources) and the prevalence and incidence of respiratory symptoms was studied in a random sample cohort of 4400 Leicestershire children aged 1-5 years surveyed in 1998 and again in 2001. Annual exposure to primary PM(10) was calculated for the home address using the Airviro dispersion model and adjusted odds ratios (ORS) and 95% confidence intervals were calculated for each microg/m(3) increase.
  
  
  RESULTS
  Exposure to primary PM(10) was associated with the prevalence of cough without a cold in both 1998 and 2001, with adjusted ORs of 1.21 (1.07 to 1.38) and 1.56 (1.32 to 1.84) respectively. For night time cough the ORs were 1.06 (0.94 to 1.19) and 1.25 (1.06 to 1.47), and for current wheeze 0.99 (0.88 to 1.12) and 1.28 (1.04 to 1.58), respectively. There was also an association between primary PM(10) and new onset symptoms. The ORs for incident symptoms were 1.62 (1.31 to 2.00) for cough without a cold and 1.42 (1.02 to 1.97) for wheeze.
  
  
  CONCLUSIONS
  In young children there was a consistent association between locally generated primary PM(10) and the prevalence and incidence of cough without a cold and the incidence of wheeze which was independent of potential confounders.
authors.affiliation: MRC Institute for Environment and Health, University of Leicester, Leicester, UK.
authors.forename: N
authors.initials: N
authors.lastname: Pierse
authors.forename: L
authors.initials: L
authors.lastname: Rushton
authors.forename: R S
authors.initials: RS
authors.lastname: Harris
authors.forename: C E
authors.initials: CE
authors.lastname: Kuehni
authors.forename: M
authors.initials: M
authors.lastname: Silverman
authors.forename: J
authors.initials: J
authors.lastname: Grigg
mesh_terms: D000397:Air Pollution / Q000009:adverse effects*; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012111:Residence Characteristics; D012120:Respiration Disorders / Q000209:etiology*; D011795:Surveys and Questionnaires; D001335:Vehicle Emissions / Q000009:adverse effects*
chemical_list: D001335:Vehicle Emissions