title: New benzimidazoles as thrombopoietin receptor agonists.
abstract: A novel benzimidazole series of small-molecule thrombopoietin receptor agonists has been discovered. Herein, we discuss the preliminary exploration of structure-activity relationships within this chemotype.
authors.affiliation: Medicinal Chemistry and Oncology Research Departments, Microbial, Musculoskeletal and Proliferative Diseases, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. igor.2.safonov@gsk.com
authors.forename: Igor G
authors.initials: IG
authors.lastname: Safonov
authors.forename: Dirk A
authors.initials: DA
authors.lastname: Heerding
authors.forename: Richard M
authors.initials: RM
authors.lastname: Keenan
authors.forename: Alan T
authors.initials: AT
authors.lastname: Price
authors.forename: Connie L
authors.initials: CL
authors.lastname: Erickson-Miller
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Hopson
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Levin
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Lord
authors.forename: Peter M
authors.initials: PM
authors.lastname: Tapley
mesh_terms: D000143:Acids / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry; D018121:Receptors, Cytokine / Q000819:agonists* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013926:Thrombopoietin / Q000378:metabolism*
chemical_list: D000143:Acids; D001562:Benzimidazoles; D009284:Naphthols; D018121:Receptors, Cytokine; D013926:Thrombopoietin; C031000:benzimidazole