PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
Lee
Sun Young
SY
College of Pharmacy, Chungbuk National University, Chungbuk, Korea.
Hwang
Dae Youn
DY
Kim
Young Kyu
YK
Lee
Jae Woong
JW
Shin
Im Chul
IC
Oh
Ki Wan
KW
Lee
Myung Koo
MK
Lim
Jong Seok
JS
Yoon
Do Young
DY
Hwang
Se Jin
SJ
Hong
Jin Tae
JT
D016229:Amyloid beta-Peptides / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D003620:Dantrolene / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005786:Gene Expression Regulation; D041722:Genes, Transgenic, Suicide; D018698:Glutamic Acid / Q000494:pharmacology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009154:Mutation / Q000235:genetics*; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology / Q000633:toxicity*; D016716:PC12 Cells; D053766:Presenilin-2; D021381:Protein Transport; D051381:Rats; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D008565:Membrane Proteins; D009498:Neurotoxins; D053766:Presenilin-2; D019837:Ryanodine Receptor Calcium Release Channel; D018698:Glutamic Acid; C505409:Casp3 protein, mouse; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; D003620:Dantrolene; D002118:Calcium