title: [Drug combinations: statins and niacin].
abstract: Combination of statins with niacin appears to be an attractive association, in the presence of mixed dyslipidemia with low HDL-c levels, when monotherapy is insufficient to achieve target lipid levels. Clinical benefits were observed by the combination of statins with niacin in the FATS, HATS and ARBITER 2 trials, showing attenuation of atherosclerosis development and/or reduction in coronary events following favorable lipid changes. In general, this combination can be well-tolerated. Recommendations for appropriate monitoring of liver and muscle enzymes are important to reduce the rate of side effects. In addition, careful titration of each drug is recommended.
authors.affiliation: Seção clínica de Cardiogeriatria, Instituto Dante Pazzanese de Cardiologia de São Paulo.
authors.forename: Jairo Lins
authors.initials: JL
authors.lastname: Borges
mesh_terms: D017677:Age Distribution; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism; D000069059:Atorvastatin; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006538:Heptanoic Acids / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D008297:Male; D009525:Niacin / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D011758:Pyrroles / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D012737:Sex Factors; D019821:Simvastatin / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D009525:Niacin; D000069059:Atorvastatin; D019821:Simvastatin