title: Aneurysm shrinkage after endovascular repair of aortic diseases.
abstract: BACKGROUND
  There are two graft materials for endovascular repair of aortic diseases, i.e., polyester and expanded polytetrafluoroethylene (ePTFE). The latest reports have suggested that there is graft-specific difference in outcomes. The purpose of this article was to evaluate the difference in terms of aneurysm shrinkage.
  
  
  METHODS
  Eighty-six patients who underwent endovascular repair of aortic diseases were included. Forty patients had true aortic aneurysms, 8 had aortic pseudoaneurysms, and 38 had aortic dissections. Eighteen patients with true aortic aneurysms were treated with stent grafts fabricated with polyester, while the other 68 patients, including 22 patients with true aneurysms, 8 patients with pseudoaneurysms, and 38 patients with aortic dissections, were treated with stent grafts fabricated with ePTFE. All patients were followed-up by computed tomography (CT) for more than 1 year. The mean follow-up term was 28 months. Computed tomography confirmed that there were sufficiently long necks, and the aneurysm or the entry tear was completely excluded without any endoleak in all patients. The diameter of the preoperative lesion was compared with that measured on follow-up CT at 1 year and at the end of the follow-up term. Increase or decrease in the diameter by more than 5 mm was defined as a significant diameter change.
  
  
  RESULTS
  Aneurysm shrinkage was observed in 40% of patients with true aneurysms, 88% of patients with pseudoaneurysms, and 55% of patients with aortic dissections at 1 year. There was no significant increase in patients with aneurysm shrinkage at the end of follow-up in any groups. In the case of true aortic aneurysms, shrinkage of aneurysms was observed more frequently with polyester-fabricated stent grafts (67%, 13/18) than with ePTFE-fabricated ones (18%, 4/22) at 1 year (P<.01). In contrast, expansion of aneurysms was observed only in patients treated with ePTFE (14%, 3/22). Shrinkage of the descending aorta was observed in 55% of patients with acute aortic dissections and 36% of patients with chronic aortic dissections. There was no case with aortic enlargement in either group. There was no significant difference between acute and chronic dissection in terms of shrinkage of the descending aorta.
  
  
  CONCLUSIONS
  Expanded polytetrafluoroethylene appears to be effective for the treatment of pseudoaneurysms and aortic dissections. However, polyester seems to be more effective than ePTFE when true aneurysms are to be treated.
authors.affiliation: Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
authors.forename: Shao Hua
authors.initials: SH
authors.lastname: Cheng
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kato
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Shimono
authors.forename: Hideto
authors.initials: H
authors.lastname: Shinpo
authors.forename: Masaki
authors.initials: M
authors.lastname: Ishida
authors.forename: Tadanori
authors.initials: T
authors.lastname: Hirano
authors.forename: Kan
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000784:Aortic Dissection / Q000473:pathology / Q000601:surgery*; D017541:Aneurysm, False / Q000473:pathology / Q000601:surgery*; D001014:Aortic Aneurysm / Q000473:pathology / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D020959:Polyethylene; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D015607:Stents; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene; D020959:Polyethylene