title: [The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract].
abstract: OBJECTIVE
  To study the pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract.
  
  
  METHODS
  The blood sample were obtained at 0,0.083,0.5,1,1.5,2,3,4,5,7,10 h after a single dose oral administration of rhubarb (50 mg x kg(-1)). The plasma rhein concentration was determined by HPLC. The pharmacokinetics of rhein were analysed by 3P97 program.
  
  
  RESULTS
  The absorption of rhein was very fastafter oral administration of rhubarb extract in the healthy volunteers. The main pharmacokinetic parameters of rhein were C(max) (3.20 +/- 1.08) microg x mL(-1); t(max) (1.03 +/- 0.41) h; t(1/2alpha) (0.21 +/- 0.02) h; t(1/2beta) (2.68 +/- 1.09) h; MRT(5.31 +/- 1.78) h; AUC(0-infinity) (1 573.08 +/- 366.48) microg x mL(-1) min(-1), respectively.
  
  
  CONCLUSIONS
  Rhein could be absorbed rapidly and its pharmacokinetics was consistent with two-compartment model.
authors.affiliation: Institute of Integrated Traditional and Western Medicine of Peking University First Hospital, Beijing 100034, China. zwwbx@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Wang
authors.forename: Bao-Xiu
authors.initials: BX
authors.lastname: Wang
authors.forename: Xiao-Ye
authors.initials: XY
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000880:Anthraquinones / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D012250:Rheum / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D004365:Drugs, Chinese Herbal; C020491:rhein