Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk.
Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied 67 adults with advanced periodontitis requiring full-mouth tooth extraction. Blood samples were obtained: (1) at initial presentation, immediately prior to treatment of presenting symptoms; (2) one to two weeks later, before all teeth were removed; and (3) 12 weeks after full-mouth tooth extraction. After full-mouth tooth extraction, there was a significant decrease in C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen, and white cell and platelet counts. This study shows that elimination of advanced periodontitis by full-mouth tooth extraction reduces systemic inflammatory and thrombotic markers of cardiovascular risk. Analysis of the data supports the hypothesis that treatment of periodontal disease may lower cardiovascular risk, and provides a rationale for further randomized studies.
Taylor
B A
BA
Sydney Dental Hospital, 2 Chalmers Street, Surry Hills NSW 2010, Australia. barbara.taylor@email.cs.nsw.gov.au
Tofler
G H
GH
Carey
H M R
HM
Morel-Kopp
M-C
MC
Philcox
S
S
Carter
T R
TR
Elliott
M J
MJ
Kull
A D
AD
Ward
C
C
Schenck
K
K
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D006973:Hypertension / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood*; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000628:therapy*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010976:Platelet Count; D012307:Risk Factors; D012907:Smoking / Q000097:blood; D013927:Thrombosis / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood; D014081:Tooth Extraction
D018836:Inflammation Mediators; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D002097:C-Reactive Protein; D010959:Tissue Plasminogen Activator