Peyronie's disease: a silent consequence of diabetes mellitus.
OBJECTIVE
To investigate the clinical characteristics of patients with Peyronie's disease (PD) and diabetes mellitus (DM).


METHODS
During an 8-year period, a total of 307 men seen at our outpatient clinic were diagnosed with PD. Clinical characteristics, penile deformities and the erectile status of patients with PD and DM together (n=102) were retrospectively analyzed and compared to patients with PD alone with no risk factors for systemic vascular diseases (n=97).


RESULTS
The prevalence of PD among men with DM and sexual dysfunction was 10.7%. The mean age of diabetic patients with PD was (55.9+/-8.9) years; in the no risk factor group it was (48.5+/-9.0) years (P < 0.05). The median duration of DM was 5 years. The majority of diabetic patients with PD (56.0%) presented in the chronic phase (P < 0.05), and they were more likely to have a severe penile deformity (>60 degrees) than the no risk factor group (P < 0.05). In the diabetic group, the most common presenting symptom was penile curvature (81.4%), followed by a palpable nodule on the shaft of the penis (22.5%) and penile pain with erection (14.7%). A total of 19.6% of patients were not aware of their penile deformities in the diabetic group. Erectile function, provided by history and in response to intracavernosal injection and a stimulation test, was significantly diminished in patients with PD and DM (P < 0.05).


CONCLUSIONS
DM probably exaggerates the fibrotic process in PD. Diabetic patients with PD have a higher risk of severe deformity and erectile dysfunction (ED). PD seems to be a silent consequence of DM and should be actively sought in diabetic men.
Tefekli
A
A
Department of Urology, Istanbul University, Istanbul Medical Faculty, Istanbul 34390, Turkey.
Kandirali
E
E
Erol
B
B
Tunc
M
M
Kadioglu
A
A
D000328:Adult; D048909:Diabetes Complications / Q000473:pathology; D007172:Erectile Dysfunction / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies