Lambda light chain deposition disease in a renal allograft.
Light chain deposition disease (LCDD) of the kidney is characterized by deposition of monoclonal light chains predominantly in glomeruli and in tubular basement membranes. The disease is frequently associated with a lymphoproliferative disorder, and the majority of cases are caused by deposition of kappa light chains. Although the occurrence of de novo multiple myeloma after renal transplantation is uncommon, there are several reports of LCDD involving renal allografts, either de novo or in patients with a diagnosis of LCDD prior to transplantation. To the best of our knowledge, all previously described cases in allografts have been in patients with kappa chain deposition. The relative importance of intrinsic properties of the kidney in predisposing to either kappa or lambda light chain deposition is not known. We present a case of LCDD caused by deposition of lambda light chains in a patient who received a cadaveric renal transplant.
Tanenbaum
N D
ND
Division of Nephrology, Duke University Medical Center and Durham VA Medical Center, Durham, North Carolina 27717, USA. tanen001@mc.duke.edu
Howell
D N
DN
Middleton
J P
JP
Spurney
R F
RF
D058186:Acute Kidney Injury / Q000209:etiology; D000368:Aged; D002196:Capillaries / Q000473:pathology / Q000648:ultrastructure; D001026:Coronary Artery Bypass; D005920:Glomerular Mesangium / Q000276:immunology / Q000473:pathology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D007683:Kidney Tubular Necrosis, Acute / Q000150:complications; D008297:Male; D010265:Paraproteinemias / Q000276:immunology / Q000473:pathology; D012079:Renal Circulation
D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains