title: Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome.
abstract: OBJECTIVE
  Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI).
  
  
  METHODS
  Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7-14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume.
  
  
  RESULTS
  Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects.
  
  
  CONCLUSIONS
  Our findings provide new evidence of abnormal thalamic volume in pediatric TS.
authors.affiliation: Department of Psychiatry, Inha University Hospital and College of Medicine, Incheon, South Korea. soulfree@inha.ac.kr
authors.forename: J-S
authors.initials: JS
authors.lastname: Lee
authors.forename: S-S
authors.initials: SS
authors.lastname: Yoo
authors.forename: S-Y
authors.initials: SY
authors.lastname: Cho
authors.forename: S-M
authors.initials: SM
authors.lastname: Ock
authors.forename: M-K
authors.initials: MK
authors.lastname: Lim
authors.forename: L P
authors.initials: LP
authors.lastname: Panych
mesh_terms: D000293:Adolescent; D002648:Child; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013788:Thalamus / Q000002:abnormalities* / Q000503:physiopathology*; D005879:Tourette Syndrome / Q000175:diagnosis* / Q000503:physiopathology*