NKG2D in NK and T cell-mediated immunity.
One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gammadelta-TcR+ T cells and alphabeta-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.
Ogasawara
Kouetsu
K
Department of Microbiology & Immunology and Cancer Research Institute, University of California-San Francisco, 513 Parnassus Avenue, HSE1001G, San Francisco, CA 94143, USA.
Lanier
Lewis L
LL
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism*; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
D055655:NK Cell Lectin-Like Receptor Subfamily K