Large animal models: baboons for trauma, shock, and sepsis studies.
A few limited examples of large animal models are outlined, with the main emphasis on baboon models. The baboon offers all the advantages of a large animal and is comparable with humans in nearly all physiological and immunological aspects. In addition, cross-reactivity with human therapeutic and diagnostic reagents allows testing of new species-specific therapies such as antihuman antibodies, on the one hand, and monitoring with available human analytical procedures, on the other.
Redl
Heinz
H
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, A-1200 Vienna, Austria. office@lbitrauma.org
Bahrami
Soheyl
S
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D023421:Models, Animal; D010215:Papio; D018805:Sepsis / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D012771:Shock, Hemorrhagic / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D012774:Shock, Traumatic / Q000378:metabolism / Q000473:pathology / Q000628:therapy