title: Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats.
abstract: In India, drumstick (Moringa oleifera Lam. (Moringaceae)) is commonly used as a phytotherapeutic agent. The effect of oral administration of aqueous and alcoholic extract of Moringa oleifera root-wood on calcium oxalate urolithiasis has been studied in male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with aqueous and alcoholic extract of Moringa oleifera root-wood significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was also significantly lowered by curative and preventive treatment using aqueous and alcoholic extracts. The results indicate that the root-wood of Moringa oleifera is endowed with antiurolithiatic activity.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, K.L.E.S's College of Pharmacy, J.N.M.C. Campus, Nehru Nagar, Belgaum 590010, Karnataka, India. rvkaradi@yahoo.com
authors.forename: Ravindra V
authors.initials: RV
authors.lastname: Karadi
authors.forename: Navneet B
authors.initials: NB
authors.lastname: Gadge
authors.forename: K R
authors.initials: KR
authors.lastname: Alagawadi
authors.forename: Rudraprabhu V
authors.initials: RV
authors.lastname: Savadi
mesh_terms: D000818:Animals; D019855:Ethylene Glycol / Q000633:toxicity*; D005260:Female; D006959:Hyperoxaluria / Q000139:chemically induced / Q000150:complications; D008297:Male; D029588:Moringa oleifera / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D052878:Urolithiasis / Q000188:drug therapy* / Q000209:etiology; D014934:Wood
chemical_list: D019855:Ethylene Glycol