Heterotopic ossification in Guillain-Barré syndrome: incidence and effects on functional outcome with long-term follow-up.
OBJECTIVE
To define the incidence, effects on functional abilities, and possible causation of heterotopic ossification (HO) in Guillain-Barré syndrome (GBS) patients admitted for inpatient rehabilitation.


METHODS
Long-term prospective study on neurologic and functional outcome of GBS patients admitted for rehabilitation.


METHODS
Rehabilitation department, inpatient and outpatient, within a university-affiliated medical center.


METHODS
All GBS patients admitted for rehabilitation and followed for a minimum of 3 years.


METHODS
Not applicable.


METHODS
Presence of HO, factors that may be etiologically significant, and effects on functionality. Data included: medical interventions, Disability Grading Scale, need for assisted ventilation, electrodiagnostic findings, autonomic function, standard neuro-musculo-skeletal evaluation, and hospital length of stay.


RESULTS
Four (6%) of 65 patients had HO, 24 of whom required mechanical ventilation. All had decreased range of motion in the involved hips that affected mobility.


CONCLUSIONS
Even though it has been rarely reported, HO does occur in GBS and affects functional outcome.
Zeilig
Gabi
G
Department of Neurological Rehabilitation, Chaim Sheba Medical Center, Tel Hashomer; and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. gavriel.zeilig@sheba.health.gov.il
Weingarden
Harold P
HP
Levy
Richard
R
Peer
Inbal
I
Ohry
Avi
A
Blumen
Nava
N
D000203:Activities of Daily Living; D000328:Adult; D000367:Age Factors; D000554:Ambulatory Care Facilities; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000453:epidemiology* / Q000534:rehabilitation; D006801:Humans; D007902:Length of Stay / Q000639:trends*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000175:diagnosis / Q000453:epidemiology* / Q000534:rehabilitation; D026741:Physical Therapy Modalities; D011336:Probability; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology; D012047:Rehabilitation Centers; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome