title: Cytotoxicity, haematotoxicity and genotoxicity of high molecular mass arborescent polyoxyethylene polymers with polyglycidol-block-containing shells.
abstract: We have examined the impact on biological systems of some newly synthesised polyoxyethylene polymers using in vitro assays. Toxicity was tested by the 3-[4,5-dimethylthiazole-2-yl]-2,5 diphenyltetrazolium bromide (MTT) assay, haemolysis was assessed, and an ethidium bromide (EB) assay was used to study interactions between the polymers and DNA. All the assay data showed that the polymers are biocompatible. No differences were found between generations (i.e. macromolecule sizes). The results encourage continuing studies on the clinical use of these molecules as drug carriers.
authors.affiliation: Department of General Biophysics, University of Lodz, 12/16 Banacha St., 90-237 Lodz, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Klajnert
authors.forename: Wojciech
authors.initials: W
authors.lastname: Walach
authors.forename: Maria
authors.initials: M
authors.lastname: Bryszewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dworak
authors.forename: Dzmitry
authors.initials: D
authors.lastname: Shcharbin
mesh_terms: D000818:Animals; D016466:CHO Cells; D016923:Cell Death / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004996:Ethidium; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008970:Molecular Weight; D009153:Mutagens / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000633:toxicity*; D011108:Polymers / Q000737:chemistry / Q000633:toxicity*; D011409:Propylene Glycols / Q000737:chemistry* / Q000633:toxicity; D017186:Titrimetry
chemical_list: D009153:Mutagens; D011108:Polymers; D011409:Propylene Glycols; C502907:polyglycidol; D011092:Polyethylene Glycols; D004996:Ethidium