title: BioGRID: a general repository for interaction datasets.
abstract: Access to unified datasets of protein and genetic interactions is critical for interrogation of gene/protein function and analysis of global network properties. BioGRID is a freely accessible database of physical and genetic interactions available at http://www.thebiogrid.org. BioGRID release version 2.0 includes >116 000 interactions from Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens. Over 30 000 interactions have recently been added from 5778 sources through exhaustive curation of the Saccharomyces cerevisiae primary literature. An internally hyper-linked web interface allows for rapid search and retrieval of interaction data. Full or user-defined datasets are freely downloadable as tab-delimited text files and PSI-MI XML. Pre-computed graphical layouts of interactions are available in a variety of file formats. User-customized graphs with embedded protein, gene and interaction attributes can be constructed with a visualization system called Osprey that is dynamically linked to the BioGRID.
authors.affiliation: Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
authors.forename: Chris
authors.initials: C
authors.lastname: Stark
authors.forename: Bobby-Joe
authors.initials: BJ
authors.lastname: Breitkreutz
authors.forename: Teresa
authors.initials: T
authors.lastname: Reguly
authors.forename: Lorrie
authors.initials: L
authors.lastname: Boucher
authors.forename: Ashton
authors.initials: A
authors.lastname: Breitkreutz
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D003196:Computer Graphics; D030541:Databases, Genetic; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005796:Genes; D006801:Humans; D020407:Internet; D008957:Models, Genetic; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D018511:Systems Integration; D014584:User-Computer Interface
chemical_list: D046912:Multiprotein Complexes