title: Long-term outcome of patients who require renal replacement therapy after cardiac surgery.
abstract: OBJECTIVE
  Acute renal failure is a serious complication of cardiac surgery. We studied the long-term survival and quality of life of patients requiring renal replacement therapy after cardiac surgery, since they represent a heavy burden on hospital resources and their outcome has never been adequately evaluated.
  
  
  METHODS
  Out of 7846 consecutive cardiac surgical patients, 126 (1.6%) required postoperative renal replacement therapy: their preoperative status and hospital course was compared with patients who had no need of postoperative renal replacement therapy. A multivariate analysis identified predictors of renal replacement therapy. Long-term survival and quality of life was collected in patients who had renal replacement therapy and in case-matched controls.
  
  
  RESULTS
  Hospital mortality in the study group was 84/126 (66.7%) vs. 118/7720 (1.5%) in the control population (P 1000 mL, chronic obstructive pulmonary disease and age.
  
  
  CONCLUSIONS
  This study confirms that the in-hospital mortality of patients requiring renal replacement therapy is high and shows a low long-term mortality with reasonable quality of life in patients discharged from hospital alive.
authors.affiliation: Università Vita-Salute di Milano, IRCCS San Raffaele Hospital, Department of Cardiovascular Anaesthesia and Intensive Care, Italy. landoni.giovanni@hsr.it
authors.forename: G
authors.initials: G
authors.lastname: Landoni
authors.forename: A
authors.initials: A
authors.lastname: Zangrillo
authors.forename: A
authors.initials: A
authors.lastname: Franco
authors.forename: G
authors.initials: G
authors.lastname: Aletti
authors.forename: A
authors.initials: A
authors.lastname: Roberti
authors.forename: M G
authors.initials: MG
authors.lastname: Calabrò
authors.forename: G
authors.initials: G
authors.lastname: Slaviero
authors.forename: E
authors.initials: E
authors.lastname: Bignami
authors.forename: G
authors.initials: G
authors.lastname: Marino
mesh_terms: D058186:Acute Kidney Injury / Q000601:surgery; D000758:Anesthesia; D006348:Cardiac Surgical Procedures / Q000401:mortality; D001026:Coronary Artery Bypass; D006334:Heart Function Tests; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D007902:Length of Stay; D016343:Monitoring, Intraoperative; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy; D011788:Quality of Life; D012121:Respiration, Artificial; D012307:Risk Factors; D013534:Survival; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000628:therapy