Treatment of corticosteroid dependent optic neuropathy with intravenous immunoglobulin.
OBJECTIVE
To report a patient with corticosteroid dependent optic neuropathy treated with intravenous immunoglobulin (IVIg).


METHODS
Interventional case report.


METHODS
Records review.


RESULTS
A 25-year-old woman developed bilateral vision loss with pain on eye movement in association with disk edema, dilated retinal veins, and hemorrhage. The vision improved markedly with prednisone, but she required a minimum of 20 mg/d despite concomitant therapy with methotrexate, cyclosporine, and/or mycophenolate mofetil. IVIg, 0.5 g/kg/d for 3 days each month with subsequent reduction in frequency, allowed discontinuation of all immunosuppression.


CONCLUSIONS
Corticosteroid dependent optic neuropathy was successfully treated with IVIg.
Kurz
Daryl
D
The Retina Group, Columbus, Ohio, USA.
Egan
Robert A
RA
Rosenbaum
James T
JT
D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D009901:Optic Nerve Diseases / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use*
D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D011241:Prednisone