title: Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in seven European countries to antimicrobial agents licensed in veterinary medicine.
abstract: The susceptibility of Streptococcus suis strains (n=384) isolated from diseased pigs in seven European countries to 10 antimicrobial agents was determined. For that purpose a microbroth dilution method was used according to CLSI recommendations. The following antimicrobial agents were tested: ceftiofur, cefquinome, enrofloxacin, florfenicol, gentamicin, penicillin, spectinomycin, tetracycline, tilmicosin and trimethoprim/sulphamethoxazole. Using breakpoints established by CLSI for veterinary pathogens, all strains were susceptible to ceftiofur, florfenicol, enrofloxacin and penicillin. MIC-90 values of these antibiotics were < or = 0.03, 0.5, 2 and < or = 0.13 microg/mL, respectively. A low degree of resistance was observed for gentamicin (1.3%), spectinomycin (3.6%) and trimethoprim/sulphamethoxazole (6.0%). MIC-90 values of these antibiotics were 8, 16 and 2 microg/mL, respectively. A high level of resistance was observed for tetracycline (75.1%). A MIC-90 value of 64 microg/mL was found for this antibiotic. Serotype-associated differences in MIC-90 values were observed for tetracycline, tilmicosin and trimethoprim/suphamethoxazole.
authors.affiliation: Animal Sciences Group, P.O. Box 65, 8200 AB Lelystad, The Netherlands. henk.wisselink@wur.nl
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Wisselink
authors.forename: Kees T
authors.initials: KT
authors.lastname: Veldman
authors.forename: Chris
authors.initials: C
authors.lastname: Van den Eede
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Salmon
authors.forename: Dik J
authors.initials: DJ
authors.lastname: Mevius
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D005060:Europe; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D012703:Serotyping / Q000662:veterinary; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D017011:Streptococcus suis / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents