Hypoxia down-regulates cyclic guanidine monophosphate-dependent protein kinase in fetal pulmonary vascular smooth muscle cell through generation of reactive oxygen species and promotes development of pulmonary hypertension.
Sander
Fred
F
Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA 90502, USA.
Gao
Yuansheng
Y
Raj
J Usha
JU
D000818:Animals; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism*; D015536:Down-Regulation; D005311:Fetal Hypoxia / Q000503:physiopathology*; D006976:Hypertension, Pulmonary / Q000209:etiology*; D032446:Myoblasts / Q000502:physiology; D011651:Pulmonary Artery / Q000503:physiopathology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012756:Sheep
D017382:Reactive Oxygen Species; D017869:Cyclic GMP-Dependent Protein Kinases