[Expression and biological significance of survivin and p63 in laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the expression of Survivin and p63 and their biological significance in laryngeal squamous cell carcinomas (LSCC).


METHODS
The expression of Survivin and p63 in 47 cases of tumor tissues, adjacent and normal tissues were detected using in situ hybridization.


RESULTS
Percentage of Survivin expression was 59.6% (28/47), 25.5% (12/47) in tumor tissues and adjacent tissues respectively. In contrast, normal laryngeal tissues did not express Survivin. Over expression of Survivin was strongly associated with tumor grade, TNM stage and cervical nodal metastasis. Percentage of p63 expression was 91.5% (43/47), 93.6% (44/47), 57.1% (8/14) in tumor tissues, adjacent and normal tissues respectively. The expression of p63 was not related to any clinicopathological features.


CONCLUSIONS
Survivin may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target. The up-regulation of the expression of Survivin predicts more invasion and poor prognosis. p63 has less effect on biological behaviors of LSCC.
Wen
Xiaoxia
X
Department of Otolaryngology, the Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China. wenxinger@sina.com
Gao
Ying
Y
Ji
Wenyue
W
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D000077022:Survivin
C107489:BIRC5 protein, human; C081876:CKAP4 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin