title: Titanium(II)-mediated cyclizations of (silyloxy)enynes: a total synthesis of (-)-7-demethylpiericidin A1.
abstract: A concise total synthesis of 7-demethylpiericidin A1 has been completed. The synthesis features a titanium(II)-mediated cyclization of a (silyloxy)enyne as the key step and proceeds in nine steps from tiglic aldehyde.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309-0215, USA.
authors.forename: Katie A
authors.initials: KA
authors.lastname: Keaton
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Phillips
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D003500:Cyclization; D011725:Pyridines / Q000138:chemical synthesis; D012821:Silanes / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000480:Alkynes; D011725:Pyridines; C101453:SN 198-D; D012821:Silanes; D014025:Titanium