Liver laceration associated with severe seizures after living donor liver transplantation.
Hemorrhagic complications commonly occur early after liver transplantation (LT), sometimes requiring emergent relaparotomy. However, active bleeding from the liver graft itself is a rare but life-threatening complication after living donor liver transplantation (LDLT). We report an unusual case of liver laceration with massive bleeding, associated with severe epileptic seizures as a result of tacrolimus-induced leukoencephalopathy, after LDLT. The patient was successfully rescued by conventional surgical management without a second transplantation. In conclusion, to our knowledge this is the first reported case of graft rupture due to immunosuppression-associated leukoencephalopathy after LT.
Sato
Kazushige
K
Advanced Surgical Science and Technology Division, Department of Surgery, Graduate School of Medicine, University of Tohoku, Sendai, Japan. satokazu@mail.tains.tohoku.ac.jp
Sekiguchi
Satoshi
S
Akamatsu
Yorihiro
Y
Kawagishi
Naoki
N
Enomoto
Yoshitaka
Y
Iwane
Takeru
T
Sato
Akira
A
Fujimori
Keisei
K
Satomi
Susumu
S
D000293:Adolescent; D001656:Biliary Atresia / Q000175:diagnosis / Q000601:surgery; D004630:Emergencies; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D022125:Lacerations / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D007813:Laparotomy / Q000379:methods; D008099:Liver / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors; D019106:Postoperative Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D018570:Risk Assessment; D012640:Seizures / Q000188:drug therapy / Q000209:etiology*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D007166:Immunosuppressive Agents