Anti-HBV nucleotide prodrug analogs: synthesis, bioreversibility, and cytotoxicity studies.
Several pronucleotide analogs of the model anti-HBV dinucleotide 3'-dA-U(2'OMe) have been synthesized and evaluated for stability, bioreversibility and cytotoxicity. These studies have helped identify potential candidates for further evaluation.
Padmanabhan
Seetharamaiyer
S
Spring Bank Technologies Inc., 113, Cedar Street, Suite S-7, Milford, MA 01757, USA.
Coughlin
John E
JE
Zhang
Guangrong
G
Kirk
Cassandra J
CJ
Iyer
Radhakrishnan P
RP
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002417:Cattle; D064420:Drug-Related Side Effects and Adverse Reactions; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000494:pharmacology; D063065:Organophosphonates / Q000138:chemical synthesis / Q000494:pharmacology; D011355:Prodrugs; D011817:Rabbits; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D013552:Swine; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D011355:Prodrugs; D018894:Reverse Transcriptase Inhibitors; D000225:Adenine