[Prospective 2-year clinical study of patients with positive IgG-antibodies after recovering from severe acute respiratory syndrome].
OBJECTIVE
To investigate the clinical characteristics of patients recovering from severe acute respiratory syndrome (SARS) during 2 years after the infection.


METHODS
The antibody of SARS-IgG, T cell subsets, chest CT, and the pulmonary function were observed in patients 1 month, 3 months, 6 months, and 2 years after convalescence from SARS.


RESULTS
In the 20 SARS cases, the level of antibodies was found to descend gradually and slowly during 2 years after convalescence. In the majority of patients T cell subsets recovered completely to normal range at the second examination. At the first re-examination, the rate of abnormal chest CT was 65%, and the main abnormal images included ground glass opacities, thickening of inter-lobular and intra-lobular septa, distorted lobular structure, thickened bronchovascular bundles, thickened pleura, arc shadow under the pleura, bronchiolar dilation, and honey comb like shadows. The rate of abnormal chest CT was 30% at the 4 fourth examination. At the first re-examination, the abnormal rate of KCO was highest, accompanied by abnormalities of forced expiratory volume in 1 second (FEV1) and the diffusing capacity of the lung for carbon monoxide (DLCO), and it began to recover since the third examination.


CONCLUSIONS
The level of SARS-IgG descends slowly, and it may last for a long time. The recovery of chest CT to normal may take a long time. The abnormality in pulmonary functions manifests mainly as impairment of diffusion function. Further research on SARS is necessary.
Yin
Cheng-hong
CH
Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100050, China.
Wang
Chao
C
Wen
Yan
Y
Jiang
Li
L
Lu
Qin
Q
Li
Jing-ling
JL
Wang
Jing
J
He
Zheng-yi
ZY
Zhang
Shu-wen
SW
Wang
Bao-en
BE
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology / Q000503:physiopathology; D055815:Young Adult
D000914:Antibodies, Viral; D007074:Immunoglobulin G