title: [Neuroendocrine tumor of the skin of head and neck].
abstract: BACKGROUND
  Merkel cell carcinom is a rare neuroendrocine tumor of skin which manifests it self through aggressive growth and early regional metastasis. It develops mainly in older population. Locally, the tumor spreads intracutaneously.
  
  
  METHODS
  We showed two cases (females of 89 and 70 years old) hospitalized within the last two years. The first patient was treated surgically three times. After the surgery, the patient was treated with radio therapy, and died 3 years from the begining of the treatment. The second patient with this neuroendocrine tumor with the high malignacy potential and huge regional metastasis, was treated surgiclly, and died a month and a half after the operation.
  
  
  CONCLUSIONS
  These two cases confirmed the aggressive and recidivant growth of this tumor with the difficut pathologic investigetion, and the extremlly bad prognosis inspite of the treatment.
authors.affiliation: Vojnomedicinska akademija, Klinika za maksilofacijalnu hirurgiju, Beograd.
authors.forename: Srboljub
authors.initials: S
authors.lastname: Stosić
authors.forename: Dejan
authors.initials: D
authors.lastname: Durdević
authors.forename: Ruzica
authors.initials: R
authors.lastname: Kozomara
authors.forename: Zoran
authors.initials: Z
authors.lastname: Mirković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Stosić-Opinćal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D012878:Skin Neoplasms / Q000473:pathology*