[Soluble P-selectin levels in synovial fluid and serum from patients with psoriatic arthritis].
OBJECTIVE
P-selectin is an adhesion molecule expressed by activated endothelial cells and platelets favouring the leukocyte adherence to microvascular endothelium. A soluble form of this molecule has been described, whose serum levels were found to be elevated and correlate with disease activity in rheumatoid arthritis (RA) patients. Aim of this study was to determine soluble P-selectin levels in synovial fluid (SF) and serum from patients with psoriatic arthritis (PsA), where it has never been investigated, to define its involvement in PsA synovial damage.


METHODS
we analysed, by ELISA, soluble P-selectin serum and SF levels in 100 patients presenting a knee joint effusion: 38 of them presented PsA, 40 RA and 22 osteoarthritis (OA). We examined the main clinical and laboratory parameters of these patients. Soluble P-selectin serum levels were also detected in 15 healthy subjects.


RESULTS
soluble P-selectin SF levels were significantly higher in PsA and RA patients respect to OA subjects. Soluble P-selectin SF levels were lower than those found in serum and the SF/serum ratio was higher in PsA and RA patients respect to OA. Soluble P-selectin serum levels were not significantly different among patients and controls. No correlation was found between SF and serum levels of soluble P-selectin and the main clinical parameters.


CONCLUSIONS
our study of soluble P-selectin in PsA reveals a prominent local role of this molecule, with no differences respect to RA. Histological findings may be of help in understanding the role of this adhesion molecule in PsA.
Scrivo
R
R
Cattedra di Reumatologia, Dipartimento di Clinica e Terapia Medica Applicata, Azienda Policlinico Umberto I, Università di Roma La Sapienza, Viale del Policlinico, 155 - 00161 Roma, Italia.
Spadaro
A
A
Riccieri
V
V
Bombardieri
M
M
Di Franco
M
M
Celestino
D
D
Valesini
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism; D019007:P-Selectin / Q000097:blood / Q000378:metabolism*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D044967:Serum / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism*
D015415:Biomarkers; D019007:P-Selectin