Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms.
Several studies indicate that the mu-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the mu-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2+G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.
Ide
S
S
Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo, Japan.
Kobayashi
H
H
Ujike
H
H
Ozaki
N
N
Sekine
Y
Y
Inada
T
T
Harano
M
M
Komiyama
T
T
Yamada
M
M
Iyo
M
M
Iwata
N
N
Tanaka
K
K
Shen
H
H
Iwahashi
K
K
Itokawa
M
M
Minami
M
M
Satoh
M
M
Ikeda
K
K
Sora
I
I
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000235:genetics*; D017450:Receptors, Opioid, mu / Q000235:genetics*
D017450:Receptors, Opioid, mu; D008694:Methamphetamine