title: Alterations in 5-HT1B receptor function by p11 in depression-like states.
abstract: The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
authors.affiliation: Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA.
authors.forename: Per
authors.initials: P
authors.lastname: Svenningsson
authors.forename: Karima
authors.initials: K
authors.lastname: Chergui
authors.forename: Ilan
authors.initials: I
authors.lastname: Rachleff
authors.forename: Marc
authors.initials: M
authors.lastname: Flajolet
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Zhang
authors.forename: Malika
authors.initials: M
authors.lastname: El Yacoubi
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Vaugeois
authors.forename: George G
authors.initials: GG
authors.lastname: Nomikos
authors.forename: Paul
authors.initials: P
authors.lastname: Greengard
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D017306:Annexin A2 / Q000235:genetics / Q000378:metabolism*; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003863:Depression / Q000235:genetics / Q000378:metabolism*; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism; D051381:Rats; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D020798:Two-Hybrid System Techniques; D000099248:S100 Calcium Binding Protein A10
chemical_list: D017306:Annexin A2; D000928:Antidepressive Agents; D044302:Receptor, Serotonin, 5-HT1B; D009418:S100 Proteins; D012701:Serotonin; D000099248:S100 Calcium Binding Protein A10