title: Glutamate-induced glutamate release: a proposed mechanism for calcium bursting in astrocytes.
abstract: Here we present a new model for the generation of complex calcium-bursting patterns in astrocytes, a type of brain cell recently implicated in a variety of neural functions including memory formation. The model involves two positive feedback processes, in which the key feedback species are calcium ion and glutamate. The latter is the most abundant excitatory neurotransmitter in the brain and has been shown to be involved in bidirectional communication between astrocytes and nearby neurons. The glutamate feedback process considered here is shown to be critical for the generation of complex bursting oscillations in the astrocytes and to, perhaps, code for information which may be passed from neuron to neuron via the astrocyte. These processes may be involved in memory storage and formation as well as in mechanisms which lead to dynamical diseases such as epilepsy.
authors.affiliation: Department of Chemistry, Indiana University--Purdue University at Indianapolis (IUPUI), Indianapolis, Indiana 46202, USA.
authors.forename: Raima
authors.initials: R
authors.lastname: Larter
authors.forename: Melissa Glendening
authors.initials: MG
authors.lastname: Craig
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology*; D001921:Brain / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018698:Glutamic Acid