[Smooth myocytes of cerebral arteries at the emergency stage of hypertension].
The objective of this study was to analyze the structural modifications of smooth myocytes (SM) in the tunica media of cerebral arteries at the emergency stage of hypertension. SM were isolated by the method of targeted alkaline dissociation from the tunica media of medial cerebral artery in 22 pups (10 animals comprising the control group). Emergency stage of hypertension was induced by an experimental aortal coarctation. Mathematical analysis of parameters of arterial pressure, inner diameter and tunica media thickness is indicative of a reduction of permissible tensile strength of cerebral arteries. The transformation of vascular SM was demonstrated that included the increase in their dimensions and the decrease of their nuclear/cytoplasmic ratio. Destructive and compensatory-adaptive SM changes (increase of nuclear DNA content and of the proportion of binuclear forms) were detected. These changes in the structure of arterial SM population in combination with the decrease of permissible tensile strength, may contribute to an increased risk of vascular wall rupture and the development of an acute dysfunction of cerebral circulation.
Ial'tsev
A V
AV
Gansburgskiĭ
A N
AN
D000818:Animals; D002536:Cerebral Arteries / Q000473:pathology*; D004285:Dogs; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D032389:Myocytes, Smooth Muscle / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology