title: Sero-prevalence of hepatitis B surface antigen (HBsAg) in pregnant women in Port Harcourt, Nigeria.
abstract: OBJECTIVE
  Hepatitis B Virus (HBV) infection is a global public health problem and is endemic in Asia and Sub-Saharan Africa, including Nigeria. Vertical transmission of HBV infection is thought to be a major mode of transmission in endemic areas. This study was therefore undertaken to determine the sero-prevalence of Hepatitis B surface antigen (HBsAg) on pregnant women in Port Harcourt, Nigeria, in an effort to obtain baseline information on disease burden in this locality, in order to institute public health measures to reduce transmission.
  
  
  METHODS
  Serial recruitment of 600 women attending the ante-natal clinic at the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. HBsAg screening was done using a rapid ELISA Kit.
  
  
  RESULTS
  26(4.3%) of the 600 subjects tested positive to HBsAg. Blood transmission, dental manipulations, tattooing and circumcision were found not to be significant modes of transmission of HBV infection in Port Harcourt.
  
  
  CONCLUSIONS
  There is an intermediate prevalence (4.3%) of HBV infection in pregnant women in Port Harcourt, Nigeria. The need to institute public health measures to reduce disease burden and transmission, including routine screening of all pregnant mothers for HBV infection and early passive/active immunisation of babies born to HBsAg--positive mothers is advocated.
authors.affiliation: Department of Obstetrics and Gynaecology, College of Health Sciences, University of Port Harcourt, Port Harcourt, Nigeria.
authors.forename: C I
authors.initials: CI
authors.lastname: Akani
authors.forename: A C
authors.initials: AC
authors.lastname: Ojule
authors.forename: H C
authors.initials: HC
authors.lastname: Opurum
authors.forename: A A
authors.initials: AA
authors.lastname: Ejilemele
mesh_terms: D000293:Adolescent; D000328:Adult; D003906:Developing Countries / Q000706:statistics & numerical data; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006784:Hospitals, Teaching / Q000706:statistics & numerical data; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D009549:Nigeria / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000821:virology; D016036:Seroepidemiologic Studies
chemical_list: D006514:Hepatitis B Surface Antigens