Forearm vascular response to nitric oxide and calcitonin gene-related peptide: comparison between migraine patients and control subjects.
The forearm vascular response to nitric oxide (NO) and calcitonin gene-related peptide (CGRP) was investigated in 10 migraine patients and 10 matched control subjects. Changes in forearm blood flow (FBF) during intrabrachial infusion of: (i) serotonin (releasing endogenous NO), (ii) sodium nitroprusside (SNP, exogenous NO-donor), and (iii) CGRP were measured using venous occlusion plethysmography. Flow-mediated dilation (FMD) of the brachial artery, a measure for the endogenous release of NO reactive to occlusion, was measured using ultrasound and expressed as percentage change vs. baseline diameter. FBF ratio (i.e. FBF in the infused over the control arm) at baseline (1.1 +/- 0.1) did not differ between both populations. Serotonin, SNP and CGRP induced a dose-dependent increase (P < 0.001) in FBF ratio in controls (to 2.8 +/- 0.3, 6.7 +/- 1.4 and 6.9 +/- 1.2 at the highest dose, respectively) and migraineurs (2.5 +/- 0.4, 5.6 +/- 0.8 and 6.5 +/- 1.3, respectively); these ratios did not differ between both groups. FMD was comparable in control subjects (5.8 +/- 1%) and migraine patients (5.2 +/- 1%). Based on the forearm vascular response to NO and CGRP, migraine patients do not display generalized changes in vascular function.
de Hoon
J N J M
JN
Centre for Clinical Pharmacology, University Hospital Gasthuisberg (K.U.Leuven), Leuven, Belgium.
Smits
P
P
Troost
J
J
Struijker-Boudier
H A J
HA
Van Bortel
L M A B
LM
D000328:Adult; D001916:Brachial Artery / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage*; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008881:Migraine Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000008:administration & dosage; D009599:Nitroprusside / Q000008:administration & dosage; D010991:Plethysmography; D012039:Regional Blood Flow / Q000187:drug effects* / Q000502:physiology*; D012701:Serotonin / Q000008:administration & dosage; D018490:Serotonin Agents / Q000008:administration & dosage; D014664:Vasodilation / Q000187:drug effects
D020030:Nitric Oxide Donors; D018490:Serotonin Agents; D009599:Nitroprusside; D009569:Nitric Oxide; D012701:Serotonin; D015740:Calcitonin Gene-Related Peptide