Phytochemical studies on Stemona plants: isolation of stemofoline alkaloids.
Six new stemofoline alkaloids, (2'R)-hydroxystemofoline (5), (3'R)-stemofolenol (6), (3'S)-stemofolenol (7), 1',2'-didehydrostemofoline-N-oxide (8), the first C(19) stemofoline alkaloid, methylstemofoline (9), and the first glycosidated Stemona alkaloid, stemofolinoside (10), and three known alkaloids, (2'S)-hydroxystemofoline (2), (11Z)-1',2'-didehydrostemofoline (3), and (11E)-1',2'-didehydrostemofoline (4), have been isolated from a root extract of an unidentified Stemona species. The structure and relative configuration of these new alkaloids have been determined by spectral data interpretation and from semisynthetic studies.
Sastraruji
Thanapat
T
Department of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia.
Jatisatienr
Araya
A
Pyne
Stephen G
SG
Ung
Alison T
AT
Lie
Wilford
W
Williams
Morwenna C
MC
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D041901:Stemonaceae / Q000737:chemistry*; D013237:Stereoisomerism; D013785:Thailand
D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; C430220:stemofoline