title: Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region.
abstract: Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.
authors.affiliation: Department of Pediatrics, Division of Neuroproteomics, Medical University of Vienna, Austria. gert.lubec@meduniwien.ac.at
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Shin
authors.forename: Talin
authors.initials: T
authors.lastname: Gulesserian
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Verger
authors.forename: Jean-Maurice
authors.initials: JM
authors.lastname: Delabar
authors.forename: Gert
authors.initials: G
authors.lastname: Lubec
mesh_terms: D000818:Animals; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D014176:Protein Biosynthesis / Q000235:genetics; D011506:Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D020543:Proteome / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism
chemical_list: D011506:Proteins; D020543:Proteome; D012333:RNA, Messenger