Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.
A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.
Zhang
Xiaoyan
X
Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA. xzhang11@prdus.jnj.com
Urbanski
Maud
M
Patel
Mona
M
Cox
Geoffrey G
GG
Zeck
Roxanne E
RE
Bian
Haiyan
H
Conway
Bruce R
BR
Beavers
Mary Pat
MP
Rybczynski
Philip J
PJ
Demarest
Keith T
KT
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000652:urine; D005947:Glucose / Q000378:metabolism; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D051381:Rats; D011924:Rats, Zucker; D051269:Sodium-Glucose Transporter 1 / Q000037:antagonists & inhibitors; D000077203:Sodium-Glucose Transporter 2 Inhibitors
D005960:Glucosides; D007211:Indoles; D051269:Sodium-Glucose Transporter 1; D000077203:Sodium-Glucose Transporter 2 Inhibitors; C030374:indole; D005947:Glucose