Novel bioactive parathyroid hormone and related peptides in teleost fish.
We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.
Canario
Adelino V M
AV
Centro de Ciências do Mar do Algarve, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. acanario@ualg.pt
Rotllant
Josep
J
Fuentes
Juan
J
Guerreiro
Pedro M
PM
Rita Teodósio
H
H
Power
Deborah M
DM
Clark
Melody S
MS
D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D008969:Molecular Sequence Data; D010281:Parathyroid Hormone / Q000096:biosynthesis* / Q000235:genetics; D010802:Phylogeny; D023741:Takifugu / Q000235:genetics / Q000378:metabolism*
D010281:Parathyroid Hormone