title: [Morpho-functional characteristic of kidneys in mother, fetus and the offspring subjected to vibration of industrial frequency during gestation].
abstract: The aims of the present study were to investigate the nature of morpho-functional changes in the kidneys in mother, fetus and the offspring subjected to the dosed effect of vibration during gestation. The study was performed in pregnant female Wistar rats (n = 28), fetuses (n = 26) and the offspring aged 3 months (n = 20). Rats were subjected to vibration from Day 9 to Day 19 of gestation (the period of intensive metanephros development), using vibration test bench with fixed parameters: frequency of 32 Hz and acceleration of 50 m/s2. Renal structures were studied using morphometric methods, the ultrastructure of renal cells was examined. In pregnant females and in mature offspring, the nephrons of subcapsular, inrtacortical and juxtamedullary zones were studied. Taking into account organo- and histogenesis of embryonic kidney, in fetuses only nephrons of the last three stages of differentiation and S-shaped tubules were studied. It was found that in adult animals juxtamedullary and subcapsular renal zones were most sensitive to the effect of vibration. Morpho-functional signs of the damage to the filtration barrier were also noted. In the metanephros of fetuses, the maturation of nephrons was retarded, and the regular formation of intercellular junctions was disturbed. In the kidneys of immature offspring the number of nephrons was increased.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Sklianov
authors.forename: G V
authors.initials: GV
authors.lastname: Pravotorov
authors.forename: O I
authors.initials: OI
authors.lastname: Balueva
authors.forename: G M
authors.initials: GM
authors.lastname: Vakulin
mesh_terms: D000818:Animals; D005260:Female; D005315:Fetal Diseases / Q000473:pathology* / Q000503:physiopathology; D005333:Fetus / Q000473:pathology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000196:embryology* / Q000473:pathology / Q000503:physiopathology; D018811:Maternal Exposure; D009399:Nephrons / Q000196:embryology / Q000503:physiopathology / Q000648:ultrastructure*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014732:Vibration