Unclassified rhabdomyosarcoma in a patient with anti-Hu syndrome.
Anti-Hu syndrome is a paraneoplastic neurological syndrome, most frequently associated with small cell carcinoma of the lung. Subacute sensory neuronopathy is thought to be the most frequent presentation of the anti-Hu syndrome, but it seems that sensory-motor neuropathy is the most common form in the anti-Hu neuropathy. Neurological symptoms often appear before the associated cancer has been identified. Sometimes the tumor is discovered months or even a few years after the appearance of the neurological syndrome. FDG-PET scan seems a better method for finding the tumor in patients with paraneoplastic neurological syndrome and anti-Hu antibodies who had negative test results after an initial workup using radiological methods. In this case report we present a patient with the anti-Hu syndrome associated with an unclassified rhabdomyosarcoma with epitheloid cellular morphology and neuroendocrine differentiation.
Schilstra
A
A
Dienst longziekten, Academisch Ziekenhuis Maastricht. alexandraschilstra@hotmail.com
van Tuijl
J H
JH
van Suylen
R J
RJ
Faber
C G
CG
ten Velde
G P M
GP
D000368:Aged; D051959:ELAV Proteins / Q000276:immunology*; D006801:Humans; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000150:complications / Q000276:immunology*; D012208:Rhabdomyosarcoma / Q000150:complications*; D013899:Thoracic Neoplasms / Q000150:complications* / Q000473:pathology
D051959:ELAV Proteins