Current status of genetic modulation of growth factors in wound repair.
Growth factors are members of a large functional group of polypeptide regulatory molecules secreted by different cells. They are important players in orchestrating all stages of wound healing exerting their influence through autocrine and paracrine fashions within sites of injury and repair. They are mitogen, chemotactic, they regulate cell-cell interactions and influence synthesis and composition of extracellular matrix components. The use of growth factors to stimulate wound healing is a promising therapeutic approach to repair chronic tissue defects. The delivery of genetic material offers an attractive treatment modality to produce an appropriate amount of growth factor proteins within the wound site. Gene therapy might become a significant treatment modality for those wound healing pathologies refractory to other wound management approaches. This review discusses several methods of growth factor gene transfer into wound tissue.
Riedel
Katrin
K
Department of Hand, Plastic and Reconstructive Surgery, Burn Centre, BG Trauma Centre, Plastic and Hand Surgery at the University of Heidelberg, D-67071 Ludwigshafen, Germany. k_riedel1@gmx.de
Riedel
Frank
F
Goessler
Ulrich R
UR
Holle
Gisbert
G
Germann
Günter
G
Sauerbier
Michael
M
D000818:Animals; D002986:Clinical Trials as Topic; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006133:Growth Substances / Q000235:genetics*; D006801:Humans; D014945:Wound Healing / Q000235:genetics*
D006133:Growth Substances