title: LGICdb: a manually curated sequence database after the genomes.
abstract: Ligand-gated ion channels form transmembrane ionic pores controlled by the binding of chemicals. The LGICdb aims to be a non-redundant, manually curated resource offering access to the large number of subunits composing extracellularly activated ligand-gated ion channels, such as nicotinic, ATP, GABA and glutamate ionotropic receptors. Composed of more than 500 human curated entries, the XML native database has been relocated in 2004 to the EBI. Its facilities have been enhanced with a new search system, customized multiple sequence alignments and manipulation of protein structures (http://www.ebi.ac.uk/compneur-srv/LGICdb/). Despite the vast improvement of general sequence resources, the LGICdb still provide sequences unavailable elsewhere.
authors.affiliation: European Bioinformatics Institute, EMBL Wellcome-Trust Genome Campus, Hinxton CB10 1SD, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Donizelli
authors.forename: Marie-Ange
authors.initials: MA
authors.lastname: Djite
authors.forename: Nicolas
authors.initials: N
authors.lastname: Le Novère
mesh_terms: D030562:Databases, Protein; D023281:Genomics; D020407:Internet; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008024:Ligands; D020033:Protein Isoforms / Q000737:chemistry; D021122:Protein Subunits / Q000737:chemistry; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface
chemical_list: D007473:Ion Channels; D008024:Ligands; D020033:Protein Isoforms; D021122:Protein Subunits