title: Non-invasive coronary angiography using multislice computed tomography.
abstract: Non-invasive methods for detection of coronary atherosclerosis have been limited to indirect markers, such as myocardial perfusion or wall motion during exercise or pharmacological stress. However, advances in multislice computed tomography (MSCT) not allow sufficient spatial resolution for direct non-invasive imaging of the coronary arteries. This review focuses on imaging techniques and clinical applications of MSCT in human studies. Published studies of the diagnostic accuracy of MSCT in native coronary arteries and bypass grafts indicate excellent sensitivity and specificity for detection of 50% diameter stenosis. MSCT is particularly good for evaluating the origin and course of anomalous coronary arteries. MSCT offers the ability to visualise both the lumen and wall of artery, as well as to quantify coronary classification. Further technical developments promise to render MSCT the ideal non-invasive tool for direct visualisation of the coronary arteries.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Baylor University Medical Center/Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas, USA.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Schussler
authors.forename: Paul A
authors.initials: PA
authors.lastname: Grayburn
mesh_terms: D002114:Calcinosis / Q000000981:diagnostic imaging; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D005544:Forecasting; D006801:Humans; D036542:Tomography, Spiral Computed