title: Neurological soft signs as predictors of treatment response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder.
abstract: Neurological soft-sign abnormalities have been implicated in obsessive-compulsive disorder (OCD). This first comprehensive data analysis evaluated the association between baseline neurological soft signs and treatment response in 117 OCD patients treated with controlled-release fluvoxamine in a double-blind placebo-controlled trial. Total and right-sided soft signs for the responders and the nonresponders did not differ significantly. Left-sided visuospatial soft signs were significantly increased in treatment nonresponders compared to responders. These subtle neurological abnormalities may implicate a potential subgroup of OCD patients with poorer treatment response. This may have treatment implications and therefore serve as a screening tool in OCD.
authors.affiliation: Mt. Sinai School of Medicine, One Gustave Levy Place, Box 1230, NY, NY 10029, USA. Eric.Hollander@mssm.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Hollander
authors.forename: Alicia
authors.initials: A
authors.lastname: Kaplan
authors.forename: James
authors.initials: J
authors.lastname: Schmeidler
authors.forename: Haichen
authors.initials: H
authors.lastname: Yang
authors.forename: David
authors.initials: D
authors.lastname: Li
authors.forename: Lorrin M
authors.initials: LM
authors.lastname: Koran
authors.forename: Luigi M
authors.initials: LM
authors.lastname: Barbato
mesh_terms: D004311:Double-Blind Method; D016666:Fluvoxamine / Q000627:therapeutic use*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D010555:Personality Inventory / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors