title: Amphidinolide B: asymmetric synthesis of a C7-C20 synthon.
abstract: [reaction: see text] An asymmetric synthesis of a C(7)-C(20) synthon of amphidinolide B is described. The synthesis entails the construction of C(7)-C(13) and C(14)-C(20) fragments and makes extensive use of catalytic asymmetric bond constructions to establish the requisite stereochemical relationships. Fragment coupling proceeds by Suzuki cross-coupling and installs the trisubstituted diene unit that is among amphidinolide B's defining structural features.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Apsara
authors.initials: A
authors.lastname: Gopalarathnam
authors.forename: Scott G
authors.initials: SG
authors.lastname: Nelson
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; C062197:amphidinolide D; D000097442:Amphidinolides