Caffeic acid inhibits compound 48/80-induced allergic symptoms in mice.
The effect of caffeic acid on scratching behavior and vascular permeability changes induced by compound 48/80 in ICR mice were investigated. An oral dose of 500 mg/kg of caffeic acid significantly inhibited scratching behavior and vascular permeability induced by compound 48/80. The inhibitory effects of daily administration of lower doses of caffeic acid, 100 and 200 mg/kg, were also investigated; and it was found that 200 mg/kg significantly inhibited compound 48/80-induced scratching behavior after the second week of consecutive administration. The effect of 200 mg/kg of caffeic acid on scratching behavior was observed up to the third week of the treatment. The decrease in histamine content induced by compound 48/80 was significantly antagonized by 200 mg/kg. The findings suggest that caffeic acid may be effective for treating itch and edema in allergic dermatitis.
Hossen
Maria Alejandra
MA
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Inoue
Toshio
T
Shinmei
Yoshifumi
Y
Minami
Kazuhisa
K
Fujii
Yoko
Y
Kamei
Chiaki
C
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002109:Caffeic Acids / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006967:Hypersensitivity / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D016877:Oxidants / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
D000975:Antioxidants; D002109:Caffeic Acids; D016877:Oxidants; D013481:Superoxides; D003189:p-Methoxy-N-methylphenethylamine; C040048:caffeic acid