Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease.
OBJECTIVE
To investigate for the first time whether the plasma CXCL16 concentration is altered in coronary artery disease (CAD) patients.


BACKGROUND
Accumulating evidence suggests that the novel chemokine/scavenger receptor CXCL16/SR-PSOX is involved in the development of atherosclerosis and CAD.


METHODS
Using ELISA we assessed the plasma CXCL16 concentration in 40 stable angina pectoris (SAP) patients, 17 unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/non-STEMI) patients, 387 survivors of a first myocardial infarction (MI) and healthy control subjects (44 controls for SAP and UAP/non-STEMI patient groups and 387 controls for post-MI patients).


RESULTS
SAP patients exhibited significantly lower median CXCL16 levels (2111 pg/ml) than the corresponding control subjects (2678 pg/ml) (P=0.0012). UAP/non-STEMI patients also appeared to have lower CXCL16 levels (2192 pg/ml) compared with controls (NS). Patients investigated 3 months after MI tended (P=0.07) to have lower CXCL16 levels (2529 pg/ml) than the corresponding controls (2638 pg/ml). There were no significant correlations between CXCL16 levels and different measures of CAD severity determined by quantitative coronary angiography in post-MI patients. Neither patients nor controls exhibited significant correlations between CXCL16 levels and plasma lipoprotein fractions, inflammatory cytokines, C-reactive protein or numbers of inflammatory cells in peripheral blood.


CONCLUSIONS
The finding that lower plasma CXCL16 concentration is associated with CAD might indicate a potential atheroprotective function of CXCL16.
Sheikine
Yuri
Y
Experimental Cardiovascular Research Unit, Center for Molecular Medicine, L8:03, S-17176, Karolinska University Hospital, Stockholm, Sweden. yuri.sheikine@cmm.ki.se
Bang
Charlotte Sahlberg
CS
Nilsson
Lennart
L
Samnegård
Ann
A
Hamsten
Anders
A
Jonasson
Lena
L
Eriksson
Per
P
Sirsjö
Allan
A
D001774:Blood Chemical Analysis; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D051116:Receptors, Scavenger / Q000097:blood*; D018709:Statistics, Nonparametric; D013548:Sweden
C423727:CXCL16 protein, human; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger