title: Fanconi anemia (cross)linked to DNA repair.
abstract: Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.
authors.affiliation: Center for Biomedical Genetics, Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Niedernhofer
authors.forename: Astrid S
authors.initials: AS
authors.lastname: Lalai
authors.forename: Jan H J
authors.initials: JH
authors.lastname: Hoeijmakers
mesh_terms: D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics; D004265:DNA Helicases / Q000235:genetics* / Q000502:physiology*; D004260:DNA Repair / Q000235:genetics*; D005199:Fanconi Anemia / Q000209:etiology* / Q000235:genetics*; D051856:Fanconi Anemia Complementation Group Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans
chemical_list: C102108:BACH1 protein, human; D050976:Basic-Leucine Zipper Transcription Factors; D051856:Fanconi Anemia Complementation Group Proteins; D004265:DNA Helicases