[Theophylline semi-solid matrices containing polyethyleneglycols. 3--Mechanism of release].
Some rheologic mesures made on a PEG range ranking from PEG 300 to PEG 6000 and containing, as a theophylline plot indicate an expected result: the viscosity increases with the molecular mass of the polymer. These same measures made on a binary mixture of PEG composed of 95% PEG 300, liquid, and 5% of solid, thickening, make appear the peculiarity of the binary mixtures of PEG: the viscosity of the binary mixture of PEG is higher than the one of the solid PEG. This "paradoxical" viscosity results, apparently, on one side from the concomitant translation and opposed of the respective points of vitrous transition of the vehicle (liquid PEG) and of the thickening (solid PEG); and on the other side, of the different solidifications of the chains of different polymers forming the binary mixture.
Ortigosa
A Cl
AC
Laboratoire de Pharmacie Galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, Montpellier.
Lasserre
Y J
YJ
D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000737:chemistry; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D016503:Drug Delivery Systems; D005079:Excipients; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry
D001993:Bronchodilator Agents; D005079:Excipients; D011092:Polyethylene Glycols; D013806:Theophylline