title: [The problem of reinforcement. From behavioural control to neurochemical background and the development of psychopathologies].
abstract: At the first part of the paper a number of conceptions about psychophysiological mechanisms of reinforcement and its role in brain system activity is presented. At the second part, a significance of the mesolimbic and mesocortical dopaminergic systems in reinforcement process and the relationships between different components of behavioural control (signal, memory, actions, etc.) and intensity of dopamine transmission at the level of n. accumbens and frontal cortex are considered. At the final part of the paper the results of development of some psychopathologies and marginal conditions, related to a low or high content of dopamine in the above-mentioned structures, and possible neurophysiological mechanisms of their formation are presented.
authors.forename: G A
authors.initials: GA
authors.lastname: Grigor'ian
mesh_terms: D001519:Behavior / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000209:etiology* / Q000378:metabolism / Q000523:psychology*; D012054:Reinforcement, Psychology
chemical_list: D004298:Dopamine