title: FlyRNAi: the Drosophila RNAi screening center database.
abstract: RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21,000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. iflockha@genetics.med.harvard.edu
authors.forename: Ian
authors.initials: I
authors.lastname: Flockhart
authors.forename: Matthew
authors.initials: M
authors.lastname: Booker
authors.forename: Amy
authors.initials: A
authors.lastname: Kiger
authors.forename: Michael
authors.initials: M
authors.lastname: Boutros
authors.forename: Susan
authors.initials: S
authors.lastname: Armknecht
authors.forename: Nadire
authors.initials: N
authors.lastname: Ramadan
authors.forename: Kris
authors.initials: K
authors.lastname: Richardson
authors.forename: Andrew
authors.initials: A
authors.lastname: Xu
authors.forename: Norbert
authors.initials: N
authors.lastname: Perrimon
authors.forename: Bernard
authors.initials: B
authors.lastname: Mathey-Prevot
mesh_terms: D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D004330:Drosophila / Q000235:genetics*; D015723:Gene Library; D049750:Genome, Insect; D020407:Internet; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000235:genetics; D012984:Software; D014584:User-Computer Interface
chemical_list: D012330:RNA, Double-Stranded