title: HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma.
abstract: Tumor-associated antigens (TAAs) have been the most actively employed targets in the clinical diagnosis and treatment of human carcinoma, such as PSA in the diagnosis of prostate cancer and NY-ESO-1 in the immunotherapy of melanoma and other cancers. However, identification of TAAs has often been hampered by the complicated and laborsome laboratory procedures. In order to accelerate the process of tumor antigen discovery, and thereby improve diagnosis and treatment of human carcinoma, we have made an effort to establish a publicly available Human Potential Tumor Associated Antigen database (HPtaa) with potential TAAs identified by in silico computing (http://www.hptaa.org). Tumor specificity was chosen as the core of tumor antigen evaluation, together with other relevant clues. Various platforms of gene expression, including microarray, expressed sequence tag and SAGE data, were processed and integrated by several penalty algorithms. A total of 3518 potential TAAs have been included in the database, which is freely available to academic users. As far as we know, this database is the first one addressing human potential TAAs, and the first one integrating various kinds of expression platforms for one purpose.
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Wang
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhao
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Xu
authors.forename: Weibo
authors.initials: W
authors.lastname: Jin
authors.forename: Changning
authors.initials: C
authors.lastname: Liu
authors.forename: Huagang
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Huang
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dianqi
authors.initials: D
authors.lastname: Xin
authors.forename: Andrew J G
authors.initials: AJ
authors.lastname: Simpson
authors.forename: Lloyd J
authors.initials: LJ
authors.lastname: Old
authors.forename: Yanqun
authors.initials: Y
authors.lastname: Na
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Weifeng
authors.initials: W
authors.lastname: Chen
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D030541:Databases, Genetic; D015870:Gene Expression; D006801:Humans; D007167:Immunotherapy; D020407:Internet; D014584:User-Computer Interface
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor