title: Antihypertensive agents for aging patients who are at risk for cognitive dysfunction.
abstract: Observational and experimental data continue to accumulate about the impact of blood pressure (BP) and antihypertensive agents on cognitive function. Current evidence suggests that there is a U-shaped association between BP earlier in life and poor cognitive function and clinical dementia, including Alzheimer's disease. This association has been identified more consistently in longitudinal surveys due to the fact that BP declines when cognitive symptoms start. Lowering BP provides protection against this complication of high BP. This effect is present in the cognitively intact and in those with dementia. Antihypertensives that cross the blood brain barrier and affect the renin-angiotensin-aldosterone system (such as perindopril or losartan) or brain calcium metabolism (nitrendipine) provide additional protection beyond BP control against cognitive decline. These drugs may be preferred in such clinical situations.
authors.affiliation: Department of Internal Medicine, Palmetto Health Richland/University of South Carolina, 9 Medical Park Drive, Suite 230, Columbia, SC 29203, USA. Ihab.hajjar@palmettohealth.org
authors.forename: Ihab
authors.initials: I
authors.lastname: Hajjar
authors.forename: Michelle
authors.initials: M
authors.lastname: Keown
authors.forename: Brandy
authors.initials: B
authors.lastname: Frost
mesh_terms: D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003072:Cognition Disorders / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents