Malignant acanthosis nigricans with liver secondaries from an occult primary adenocarcinoma of gastrointestinal tract.
A 38-year-old female presented with hyperpigmented velvety plaques on the nape and the sides of the neck with diffuse pigmentation of the face and flexures suggestive of acanthosis nigricans. The dorsa of both the hands showed increased rugosity, hyperpigmentation and hyperkeratosis of the palms, suggestive of tripe palms. Investigations revealed multiple secondaries in the liver. Histopathology showed the secondaries to be from adenocarcinoma of the gastrointestinal tract.
Nair
Pradeep S
PS
Department of Dermatology and Venereology, Medical College Hospital, Trivandrum 695011, Kerala, India. bijili@asianetindia.com
Moorthy
Prasanna K
PK
Suprakasan
S
S
Jayapalan
Sabeena
S
Sarin
M
M
D000052:Acanthosis Nigricans / Q000175:diagnosis / Q000473:pathology*; D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007813:Laparotomy / Q000379:methods; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery