title: Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition.
abstract: In this report, we demonstrate a possible molecular mechanism by which a hydrophilic extract of the leaves of the fern Polypodium leucotomos (Fernblock, PL) blocks ultraviolet (UV)-induced skin photodamage. The extract inhibits UVA and UVB light induced photoisomerization of trans-urocanic acid (t-UCA), a common photoreceptor located in the stratum corneum, and also blocks its photodecomposition in the presence of oxidizing reagents such as H2O2, and titanium dioxide (TiO2). PL protects in vitro human fibroblasts from UV-induced death as well. These results suggest the potential of employing the PL extract as a component of sunscreen moistures in order to prevent photodecomposition of t-UCA, to inhibit UV-induced deleterious effects of TiO2 and to protect skin cells and endogenous molecules directly involved in skin immunosurveillance.
authors.affiliation: R&D Department, Industrial Farmacéutica Cantabria, C Arequipa 1 EDIF Ofic 5 planta, IFC, 28043 Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Capote
authors.forename: J L
authors.initials: JL
authors.lastname: Alonso-Lebrero
authors.forename: F
authors.initials: F
authors.lastname: García
authors.forename: A
authors.initials: A
authors.lastname: Brieva
authors.forename: J P
authors.initials: JP
authors.lastname: Pivel
authors.forename: S
authors.initials: S
authors.lastname: González
mesh_terms: D002478:Cells, Cultured; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D010777:Photochemistry; D032494:Polypodium / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014025:Titanium / Q000737:chemistry; D014466:Ultraviolet Rays; D014560:Urocanic Acid / Q000737:chemistry*
chemical_list: D017382:Reactive Oxygen Species; C009495:titanium dioxide; D006861:Hydrogen Peroxide; D014025:Titanium; D014560:Urocanic Acid