title: [Biochemical failure after curative treatment for localized prostate cancer].
abstract: Biochemical failure after curative treatment for localized prostate cancer is frequent. The diagnosis of biochemical failure is clear when PSA levels rise after radical prostatectomy, but may be more difficult after external beam radiation therapy. The main difficulty once biochemical failure is diagnosed is to distinguish between local and distant failure, given the low sensitivity of standard work-up exams. Metabolic imaging techniques currently under evaluation may in the future help us to localize the site of failures. There are several therapeutic options depending on the initial curative treatment, each with morbidity risks that should be considered in multidisciplinary decision-making.
authors.affiliation: Service de radio-oncologie, CHUV, 1011 Lausanne.
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Zouhair
authors.forename: Patrice
authors.initials: P
authors.lastname: Jichlinski
authors.forename: René-Olivier
authors.initials: RO
authors.lastname: Mirimanoff
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D017679:Cryotherapy; D003657:Decision Making; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012016:Reference Values; D016879:Salvage Therapy
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017430:Prostate-Specific Antigen