title: Treatment with Met-RANTES decreases bacterial translocation in experimental colitis.
abstract: BACKGROUND
  During colitis, epithelial function is impaired, leading to increased bacterial translocation. Recent studies have shown the important role of proinflammatory cytokines and chemokines, including RANTES (regulated on activation, normal T-cell expressed and secreted), in inflammatory bowel diseases (IBDs). In this study, we evaluated the role of Met-RANTES, an antagonist of the RANTES receptor, on the impairment of bacterial translocation in a rat model of colitis.
  
  
  METHODS
  Rats were randomly assigned to 3 groups. Group 1 = control, group 2 = experimental colitis, and group 3 = colitis plus Met-RANTES treatment. On day 7 after colitis was induced, plasma tumor necrosis factor-alpha colon tissue myeloperoxidase and portal blood endotoxin levels were measured. Lymph node, liver, and spleen culture quantified bacterial translocation.
  
  
  RESULTS
  Met-RANTES treatment resulted in significant decreases in colonic damage as well as bacterial translocation in experimental colitis.
  
  
  CONCLUSIONS
  These results suggest that chemokine receptor antagonists may potentially be useful in the treatment of IBDs.
authors.affiliation: Department of General Surgery, Erciyes University School of Medicine, 38039, Kayseri, Turkey. cankucuk@erciyes.edu.tr
authors.forename: Can
authors.initials: C
authors.lastname: Kucuk
authors.forename: Erdogan
authors.initials: E
authors.lastname: Sozuer
authors.forename: Sebnem
authors.initials: S
authors.lastname: Gursoy
authors.forename: Ozlem
authors.initials: O
authors.lastname: Canoz
authors.forename: Tarik
authors.initials: T
authors.lastname: Artis
authors.forename: Alper
authors.initials: A
authors.lastname: Akcan
authors.forename: Hizir
authors.initials: H
authors.lastname: Akyildiz
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Muhtaroglu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D018988:Bacterial Translocation / Q000187:drug effects*; D018946:Chemokine CCL5 / Q000031:analogs & derivatives* / Q000494:pharmacology; D003092:Colitis / Q000139:chemically induced / Q000382:microbiology / Q000503:physiopathology*; D003106:Colon / Q000187:drug effects*; D004195:Disease Models, Animal; D008297:Male; D009676:Noxae / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D014302:Trinitrobenzenesulfonic Acid / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D018946:Chemokine CCL5; D009676:Noxae; C108335:RANTES, Met-; D014302:Trinitrobenzenesulfonic Acid