Dementia in Parkinson's disease.
Dementia as a manifestation of idiopathic PD is an important feature of the disease in terms of QOL, prognosis, and clinical management. The pathophysiology of the disorder is likely a multifactorial process that encompasses derangement of multiple neuronal populations of both subcortical and cortical origin. This process results in a cognitive profile that largely reflects a dysexecutive syndrome. Currently, treatment of PDD is symptomatic. Further research is needed to elucidate the relationship of PDD to DLB and AD in hopes of developing and using appropriate therapeutic measures designed to address the underlying disease process.
Rippon
Gregory A
GA
Department of Neurology, Columbia University, New York, New York, USA.
Marder
Karen S
KS
D000978:Antiparkinson Agents / Q000627:therapeutic use; D003704:Dementia / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D015994:Incidence; D007802:Language; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D011340:Problem Solving / Q000502:physiology; D012307:Risk Factors; D013028:Space Perception / Q000502:physiology
D000978:Antiparkinson Agents