[Proton spectroscopy in Alzheimer's disease and cognitive impairment not dementia: a community study].
OBJECTIVE
To describe the proton magnetic resonance spectroscopy (1H-ERM) data in Alzheimer's disease (AD) and Cognitive Impairment Not Dementia (CIND) in a community sample.


METHODS
We investigated subjects with AD (n=6), CIND (n=7) and normal control (n=7). 1H-ERM was performed with single voxel (8 cm3) placed in temporal, parietal and occipital regions and studied metabolites were: N-acetylaspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mI).


RESULTS
NAA concentration was higher in control subjects than AD and intermediated in CIND patients. Cho parietal plus occipital and Cr parietal plus Cho occipital classified correctly 92.3% of subjects Control vs AD. Temporal mI classified 78.6% of subjects between Control vs CIND.


CONCLUSIONS
Spectroscopy can be used in the diagnosis and follow-up of individuals with cognitive impairment; evaluation of community subjects may show different patterns of brain metabolites distribution.
Azevedo
Dionísio
D
Projeto Terceira Idade (PROTER), Instituto e Departamento de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil. dionosioazevedo@uol.com.br
Bottino
Cássio M C
CM
Tatsch
Mariana
M
Hototian
Sergio R
SR
Bazzarella
Mario C
MC
Castro
Cláudio C
CC
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D016022:Case-Control Studies; D002794:Choline / Q000032:analysis / Q000378:metabolism; D003072:Cognition Disorders / Q000378:metabolism*; D003401:Creatine / Q000032:analysis / Q000378:metabolism; D004522:Educational Status; D005260:Female; D006801:Humans; D007294:Inositol / Q000032:analysis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009483:Neuropsychological Tests; D011522:Protons
D011522:Protons; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline