Coronary flow reserve and coronary microvascular functions are strongly related to serum uric acid concentrations in healthy adults.
BACKGROUND
Uric acid is a well known antioxidant; however, the relationship between serum uric acid levels and oxidative stress-caused disorders including cardiovascular diseases is not clear yet. Transthoracic Doppler echocardiographic measurement of coronary flow reserve is a useful tool to investigate coronary flow reserve and coronary microvascular functions. In this study, we investigated the possible association between serum uric acid concentrations and coronary flow reserve in healthy adults.


METHODS
One hundred healthy volunteers with normal uric acid levels, between 18 and 55 years of age, were included in this study. The study group was divided into two with regard to the serum uric acid levels. Coronary diastolic peak flow velocities were measured at baseline and after dipyridamole infusion (0.56 mg/kg over 4 min) using echocardiography.


RESULTS
Coronary flow reserve and hyperemic mean peak flow velocity were significantly greater in participants with lower serum uric acid concentrations (< or =234 micromol/l for women, < or =302 micromol/l for men) than in those with higher serum uric acid concentrations (>234 micromol/l for women, >302 micromol/l for men) (2.91+/-0.5 vs. 2.47+/-0.5, P<0.001; 66.8+/-11.4 vs. 61.1+/-16.5, P=0.04). The baseline mean peak flow velocity was significantly greater in participants with higher serum uric acid concentrations than in those with lower serum uric acid concentrations (24.7+/-4.1 vs. 23.1+/-2.4, P=0.02).


CONCLUSIONS
Lower serum uric acid concentrations might be regarded as indicative of coronary microvascular and conductance vessel functionality.
Erdogan
Dogan
D
Department of Cardiology, Konya Teaching and Medical Research Center, Baskent University, Konya, Turkey. ayodoganer@yahoo.com
Gullu
Hakan
H
Caliskan
Mustafa
M
Yildirim
Ibrahim
I
Ulus
Taner
T
Bilgi
Muhammet
M
Yilmaz
Sema
S
Muderrisoglu
Haldun
H
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000502:physiology*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D012016:Reference Values; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid