[DNA-repair modulation using derivatives of 1,4-dihydroisonicotinic acid as an example].
The influence of two derivatives of 1,4-dihydroisonicotinic acid on DNA-repair involved in chemical mutagenesis in Drosophila germ cells has been investigated. The compounds tested decreased the level of EMS-induced chromosome breakage and point mutations due to stimulation of maternal repair of DNA primary damage induced in spermatozoa as well as due to activation of DNA-repair in larvae and imago premeiotic stages of Drosophila males. Deficiency of DNA-repair systems leads to decrease in female and male germ-cell sensitivity to antimutagen action.
Dalivelia
O V
OV
Savina
N V
NV
Kuzhir
T D
TD
Goncharova
R I
RI
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D019457:Chromosome Breakage; D004260:DNA Repair; D004330:Drosophila / Q000187:drug effects / Q000235:genetics; D005020:Ethyl Methanesulfonate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007539:Isonicotinic Acids / Q000494:pharmacology*; D008297:Male; D016296:Mutagenesis / Q000187:drug effects; D009153:Mutagens / Q000494:pharmacology; D017354:Point Mutation / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
D016587:Antimutagenic Agents; D007539:Isonicotinic Acids; D009153:Mutagens; D005020:Ethyl Methanesulfonate