title: Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis.
abstract: We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA.
authors.forename: Michail S
authors.initials: MS
authors.lastname: Lionakis
authors.forename: Georgios
authors.initials: G
authors.lastname: Chamilos
authors.forename: Russell E
authors.initials: RE
authors.lastname: Lewis
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.forename: Issam I
authors.initials: II
authors.lastname: Raad
authors.forename: George
authors.initials: G
authors.lastname: Samonis
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005670:Fusarium / Q000187:drug effects* / Q000302:isolation & purification; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D009503:Neutropenia / Q000150:complications / Q000378:metabolism; D009894:Opportunistic Infections; D010419:Pentamidine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D010419:Pentamidine