Glutathione S-transferase T1 genetic mismatch is a risk factor for de novo immune hepatitis in liver transplantation.
Glutathione S-transferase T1 (GSTT1) is a drug metabolizing enzyme abundantly expressed in liver and kidney cells; it is encoded by a single gene that is absent in 20% of the Caucasian population. Our group found that some liver transplantation patients developed de novo immune hepatitis (IH) and that all of them had anti-GSTT1 antibodies. The main objective of this study was to analyze the influence of a GSTT1 mismatch between donor and recipient in the immune response and the outcome of the graft. We confirmed that only under one of the four possible genetic combinations (null recipient/positive donor) is an alloimmune response triggered with production of anti-GSTT1 antibodies. Therefore, we conclude that this genetic mismatch can be considered a risk factor for de novo IH.
Aguilera
I
I
Servicio de Inmunología, Hospital Universitario Virgen del Rocío, Sevilla, Spain. isabel.aguilera.exts@juntadeandalucia.es
Sousa
J M
JM
Gavilan
F
F
Bernardos
A
A
Wichmann
I
I
Nuñez-Roldan
A
A
D001323:Autoantibodies / Q000097:blood; D020137:Base Pair Mismatch / Q000235:genetics*; D015331:Cohort Studies; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics* / Q000276:immunology; D019693:Hepatitis, Autoimmune / Q000235:genetics*; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D016133:Polymerase Chain Reaction; D012307:Risk Factors
D001323:Autoantibodies; D005982:Glutathione Transferase; C495790:glutathione transferase T1-1, human