[Remodeling of the basement membrane and airway epithelium in patients with asthma].
Chronic inflammation is recognized as a primary factor in the development of asthma, and its role in the induction of the remodeling of the airways has recently been emphasized. Changes in airway structure such as thickening of the airway wall are common findings in cases of asthma. Thickening of the epithelial reticular basement membrane has been reported to show a positive correlation with airway hyperresponsiveness, the frequency of asthma attacks, and the numbers of fibroblasts and myofibroblasts that lie external and adjacent to it. Studies on the pathology of asthma showed changes of airway epithelium. The most common of these changes are squamous cell metaplasia, goblet cell hyperplasia and damage and shedding of airway surface epithelium.
Pałgan
Krzysztof
K
Katedra i Klinika Alergologii i Chorób Wewnetrznych Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu. inchal@amb.bydgoszcz.pl
Dziedziczko
Andrzej
A
Bartuzi
Zbigniew
Z
D001249:Asthma / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology*; D001980:Bronchi / Q000473:pathology*; D016535:Bronchial Hyperreactivity / Q000473:pathology*; D006801:Humans