title: Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia?: A preliminary study.
abstract: The present study was conducted to examine the effect of eicosapentaenoic acid supplements on pulse wave velocity (PWV) in patients with dyslipidemia as a prospective open-labeled study. Eicosapentaenoic acid supplements (1,800 mg/day) were prescribed to 40 patients, and diet therapy in consultation with a nutritionist was conducted in 44 patients as a control group. These interventions were continued for 12 months, and PWV and blood examinations were performed at the start and end of these interventions. PWV increased in the control group but not in the eicosapentaenoic acid group. After adjustment for age, gender, the initial PWV, and the changes in mean blood pressure during the study period, a general linear model univariate analysis post hoc comparison demonstrated that the change in PWV during the period of study was significantly larger in the control group (42 +/- 20 cm/s) than in the eicosapentaenoic acid group (-9 +/- 19 cm/s) (p<0.05). Thus, this preliminary study suggested that eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia. A further study with a larger number of subjects is proposed to confirm this beneficial effect of eicosapentaenoic acid supplements on arterial stiffness.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Takazawa
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Osa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Hirose
authors.forename: Akio
authors.initials: A
authors.lastname: Hirai
authors.forename: Toshiro
authors.initials: T
authors.lastname: Iketani
authors.forename: Masami
authors.initials: M
authors.lastname: Monden
authors.forename: Kyo
authors.initials: K
authors.lastname: Sanoyama
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D001158:Arteries / Q000187:drug effects / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000503:physiopathology* / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001916:Brachial Artery / Q000502:physiology; D003627:Data Interpretation, Statistical; D019587:Dietary Supplements; D050171:Dyslipidemias / Q000178:diet therapy / Q000188:drug therapy* / Q000503:physiopathology; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004548:Elasticity / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse; D012044:Regression Analysis; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology
chemical_list: D015118:Eicosapentaenoic Acid