FR177391, a new anti-hyperlipidemic agent from Serratia. I. Taxonomy, fermentation, isolation, physico-chemical properties, structure elucidation and biological activities.
In the course of screening for a new anti-hyperlipidemic agent from microbial products, we found that FR177391, produced by Serratia liquefaciens No. 1821, alleviated the decrease in lipid droplet formation in differentiated 3T3-L1 adipocyte cells, induced by the addition of tumor necrosis factor-alpha. Structural elucidation by spectroscopic methods and X-ray crystallographic analysis of its propylamide derivative revealed that FR177391 was a chlorinated macrocyclic lactone.
Sato
Bunji
B
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co Ltd, Tsukuba, Ibaraki, Japan. bunji.sato@jp.astellas.com
Nakajima
Hidenori
H
Fujita
Takashi
T
Takase
Shigehiro
S
Yoshimura
Seiji
S
Kinoshita
Takayoshi
T
Terano
Hiroshi
H
D000085:Acetates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005285:Fermentation; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D012705:Serratia / Q000737:chemistry* / Q000145:classification / Q000378:metabolism
D000085:Acetates; C508031:FR177391; D006571:Heterocyclic Compounds; D000960:Hypolipidemic Agents