[The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance].
OBJECTIVE
To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma (SACC) and its significance.


METHODS
The expression levels of FAK and PTEN in 50 cases of SACC were detected by strepravidin-peroxidase immunohistochemical technique. SPSS10.0 software was used for Chi-square test, paried Student t test and correlation analysis.


RESULTS
The expressions of FAK in salivary adenoid cystic carcinoma was 94%, and the negative expressions of PTEN was 70%.There was a significant difference between normal salivary gland and salivary adenoid cystic carcinoma (P<0.01). A significant negative relation was found between the expression intensity of FAK protein and PTEN protein(P<0.01).No correlation between the expression intensity in cribriform,tubular, and solid group was found.


CONCLUSIONS
Activation of FAK may play a strong role in the development of SACC. PTEN was abnormally expressed in SACC. No significant different expression of FAK and PTEN were found in different clinic pathological types.
Zhang
Bin
B
Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China.
Sun
Chang-fu
CF
D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism*; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism*; D012469:Salivary Glands / Q000378:metabolism
D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human