Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma.
BACKGROUND
To examine the prognostic value of markers of bone metabolism (serum PINP, BAP, and CTX-I) and serum YKL-40 in metastatic prostate carcinoma (PC).


METHODS
The biomarkers were determined by ELISAs in 153 metastatic PC patients before treatment with parenteral estrogen or total androgen ablation. The median follow-up was 4.9 years. One hundred fifteen patients died.


RESULTS
The biomarkers were increased in the patients compared to controls (P < 0.001), and related to performance status and Soloway score (except YKL-40), but not to T-category and WHO tumor grade. PINP was elevated in 87%, BAP (55%), CTX-I (33%), and YKL-40 (43%). Univariate analysis showed an association to survival: PINP (HR = 1.6, P < 0.0001), BAP (HR = 1.4, P < 0.0001), CTX-I (HR = 1.7, P < 0.0001), and YKL-40 (HR = 1.4, P = 0.004). In multivariate Cox analysis performance status, WHO grade, Soloway score, PINP, and YKL-40 were independently predictive factors.


CONCLUSIONS
High serum PINP, BAP, CTX-I, and YKL-40 are associated with poor outcome of metastatic PC patients.
Brasso
Klaus
K
Department of Urology, H:S Rigshospitalet, University of Copenhagen, Cophenhagen, Denmark.
Christensen
Ib Jarle
IJ
Johansen
Julia S
JS
Teisner
Børge
B
Garnero
Patrick
P
Price
Paul A
PA
Iversen
Peter
P
D054392:Adipokines; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D000728:Androgens / Q000627:therapeutic use; D000071451:Chitinase-3-Like Protein 1; D003718:Denmark; D004797:Enzyme-Linked Immunosorbent Assay; D004967:Estrogens / Q000627:therapeutic use; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D037102:Lectins; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D001618:beta-Lactamases / Q000097:blood*
D054392:Adipokines; D000728:Androgens; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D004967:Estrogens; D006023:Glycoproteins; D037102:Lectins; D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide; D000469:Alkaline Phosphatase; C055184:beta-lactamase TEM-3; D001618:beta-Lactamases