Hyponatremia in patients with heart failure.
Mild hyponatremia is encountered frequently in patients hospitalized for worsening heart failure. Admission plasma sodium concentration appears to be an independent predictor of increased mortality after discharge and rehospitalization. Recent studies have suggested that correction of hyponatremia may be associated with improved survival. This hypothesis is currently being studied in large prospective randomized clinical trials.
De Luca
Leonardo
L
Department of Cardiovascular and Respiratory Sciences, La Sapienza University, Rome, Italy.
Klein
Liviu
L
Udelson
James E
JE
Orlandi
Cesare
C
Sardella
Gennaro
G
Fedele
Francesco
F
Gheorghiade
Mihai
M
D006333:Heart Failure / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007010:Hyponatremia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy