Analysis of unknown compounds in gentamicin bulk samples with liquid chromatography coupled with ion trap mass spectrometry.
Six unknown compounds present in bulk gentamicin samples have been identified by ion-pairing reversed-phase liquid chromatography coupled with ion trap mass spectrometry. The structures of these unknown compounds were deduced by comparison of their fragmentation patterns with those of the available related substances and gentamicin reference substances. Seven other unknown components were partially identified.
Li
Bo
B
Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, O&N2, PB 923, Herestraat 49, B-3000 Leuven, Belgium.
Adams
Erwin
E
Van Schepdael
Ann
A
Hoogmartens
Jos
J
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002853:Chromatography, Liquid; D004340:Drug Contamination; D005839:Gentamicins / Q000737:chemistry*; D013058:Mass Spectrometry; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012680:Sensitivity and Specificity
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D004364:Pharmaceutical Preparations