title: [Spontaneous skin necrosis from acquired protein S deficiency in a renal transplant recipient].
abstract: BACKGROUND
  Spontaneous skin necrosis revealed acquired protein S deficiency due to isotype G autoantibodies.
  
  
  METHODS
  This 31-year-old male renal transplant recipient, receiving immunosuppressive treatment, was hospitalized for necrotic purpural lesions. We were not able to detect any triggering factor. Sustained anticoagulant therapy remained essential to prevent new skin lesions and perhaps more thrombotic events.
  
  
  CONCLUSIONS
  This condition is rare in adulthood, but is well described in children's purpura fulminans, especially the post-varicella form. Its mechanism remains unclear.
authors.affiliation: Service de médecine 1, Hôpital d'Avranches (50). elisabeth.laurat@ch-avranches-granville.fr
authors.forename: E
authors.initials: E
authors.lastname: Laurat
authors.forename: T
authors.initials: T
authors.lastname: Frouget
authors.forename: V
authors.initials: V
authors.lastname: Joyeux
authors.forename: C
authors.initials: C
authors.lastname: Arvieux
authors.forename: M
authors.initials: M
authors.lastname: Pommereuil
authors.forename: J
authors.initials: J
authors.lastname: Chevrant-Breton
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D009336:Necrosis; D018455:Protein S Deficiency / Q000175:diagnosis* / Q000276:immunology; D012867:Skin / Q000473:pathology*
chemical_list: D000925:Anticoagulants; D001323:Autoantibodies; D007074:Immunoglobulin G; D006493:Heparin