title: Synthesis and analgesic activity of N-Arylhydrazone derivatives of mefenamic acid.
abstract: OBJECTIVE
  A series of N-Arylhydrazone derivatives of mefenamic acid (a known non-steroidal anti-inflammatory drug) were synthesized in order to obtain new compounds with potential analgesic and anti-inflammatory activity.
  
  
  METHODS
  The structures of all synthesized compounds were confirmed by means of infrared, proton magnetic resonance and mass spectroscopy. All compounds were evaluated for their analgesic and anti-inflammatory activities by abdominal constriction test (writhing test) and carrageenan-induced rat paw edema test respectively.
  
  
  RESULTS
  Most of the synthesized compounds induced significant reduction in the writhing response when compared to control. Among them, compounds 11, 12, 15, 16, 19, 20, and 21 were significantly more potent than mefenamic acid in the writhing test. The anti-inflammatory activity of these 7 compounds were evaluated and compounds 11, 12, 16, 19 and 20 showed significant anti-inflammatory activity in comparison to control but their effect was weaker than mefenamic acid.
  
  
  CONCLUSIONS
  The antinociceptive relative activity of some of these newly synthesized compounds is greater than mefenamic acid but they are not potent anti-inflammatory agents.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Almasirad
authors.forename: Mohammad
authors.initials: M
authors.lastname: Tajik
authors.forename: Davood
authors.initials: D
authors.lastname: Bakhtiari
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Zamani
authors.forename: Reza
authors.initials: R
authors.lastname: Khorasani
authors.forename: Hadi
authors.initials: H
authors.lastname: Esmaily
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D008528:Mefenamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006835:Hydrazones; D008528:Mefenamic Acid