title: Osteoporotic compression fractures: outcomes after single- versus multiple-level percutaneous vertebroplasty.
abstract: OBJECTIVE
  To compare single- and multiple-level percutaneous vertebroplasty (PV) in terms of pain relief, activity level, and analgesic use in patients with osteoporotic vertebral compression fractures (VCFs).
  
  
  METHODS
  Institutional review board approval and informed consent were obtained, and the study was HIPAA compliant. One hundred seventy-three patients (mean age at treatment, 73.8 years +/- 11.9 [standard deviation]) with 422 symptomatic osteoporotic VCFs underwent 204 treatment sessions for over 4 years. Pain immediately before and after PV was measured by using a visual analogue scale (VAS). Pain degree, activity level, and analgesic use were assessed at 2 weeks and 1, 3, 6, 12, and 24 months after PV by using telephone interview questionnaires. Data were analyzed by using a combination of paired t tests, analysis of variance, contingency tables, and chi2 tests.
  
  
  RESULTS
  Findings of 172 PV treatment sessions for 149 patients (mean age at treatment, 73.4 years +/- 12), 110 (74%) of whom were women, were assessed; 32 treatment cases were lost to follow-up or lost owing to death. A single fracture level was treated at 65 sessions; two fracture levels, at 52 sessions; and three or more fracture levels, at 55 sessions. The mean VAS pain score decreased significantly (P < .001), from 76 +/- 21 before to 19 +/- 27 immediately after PV. Of the outcomes reported at 24 months, 82% (64 of 78 treatment sessions) were marked to complete resolution of the initial pain, 51% were complete cessation of analgesic use, and 51% were increased activity levels. These results did not differ greatly over time or when stratified into groups according to the number of fracture levels treated.
  
  
  CONCLUSIONS
  PV performed at a single fracture level and that performed at multiple fracture levels were equally effective in facilitating long-term pain relief, increased activity level, and decreased analgesic use in patients with osteoporotic VCFs.
authors.affiliation: Barnes-Jewish Hospital, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St Louis, MO 63110, USA.
authors.forename: Anand K
authors.initials: AK
authors.lastname: Singh
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Pilgram
authors.forename: Louis A
authors.initials: LA
authors.lastname: Gilula
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001843:Bone Cements; D016009:Chi-Square Distribution; D005260:Female; D005471:Fluoroscopy; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications* / Q000000981:diagnostic imaging; D010147:Pain Measurement; D019904:Polymethyl Methacrylate / Q000008:administration & dosage; D011788:Quality of Life; D015641:Radiography, Interventional; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate