title: [Influence of human gastrointestinal tract bacterial pathogens on host cell apoptosis].
abstract: Several pathogenic bacteria are able to trigger apoptosis in the host cell, but the mechanisms by which it occurs differ, and the resulting pathology can take different courses. Induction and/or blockage of programmed cell death upon infection is a result of complex interaction of bacterial proteins with cellular proteins involved in signal transduction and apoptosis. In this review we focus on pro/anti-apoptotic activities exhibited by two enteric pathogens Salmonella enterica, Yersinia spp. and gastric pathogen Helicobacter pylori. We present current knowledge on how interaction between mammalian and bacterial cell relates to the molecular pathways of apoptosis, and what is the role of apoptosis in pathogenesis.
authors.affiliation: Zakład Genetyki Bakterii, Instytut Mikrobiologii, Uniwersytet Warszawski, Warszawa.
authors.forename: Weronika
authors.initials: W
authors.lastname: Wronowska
authors.forename: Renata
authors.initials: R
authors.lastname: Godlewska
authors.forename: Elzbieta Katarzyna
authors.initials: EK
authors.lastname: Jagusztyn-Krynicka
mesh_terms: D017209:Apoptosis / Q000276:immunology*; D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology; D005759:Gastroenteritis / Q000276:immunology* / Q000382:microbiology*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D016905:Gram-Negative Bacterial Infections / Q000276:immunology*; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D012480:Salmonella Infections / Q000276:immunology; D019779:Salmonella enterica / Q000472:pathogenicity; D014774:Virulence; D015007:Yersinia / Q000472:pathogenicity; D015009:Yersinia Infections / Q000276:immunology