T cell targeted immunotherapy for autoimmune disease.
Much emphasis has been placed on the so-called "biologics" in the treatment of immune disorders within the last few years. Here we discuss the expanding horizon of potential strategies for immunotherapies targeting T lymphocytes as key effectors and regulators of autoimmunity. We review emerging reagents in a variety of animal models and human disorders that may offer new therapeutic options in current or modified iterations.
Lee
Erica
E
Department of Dermatology, Weill Medical College of Cornell University, New York, NY, USA.
Sinha
Animesh A
AA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000628:therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology*
D000911:Antibodies, Monoclonal