title: Comparison study of a traditional pulsed dye laser versus a long-pulsed dye laser in the treatment of early childhood hemangiomas.
abstract: OBJECTIVE
  The role of pulsed dye laser (PDL) in the treatment of childhood hemangiomas is still controversial because of the inherent characteristics of hemangiomas as well as the side effects of the PDL. Recently, the long pulsed dye laser (LPDL) with cryogen spray cooling (CSC) has been found relatively more effective and safer than the PDL in the treatment of port-wine stains and telangiectasia. This study was designed to compare the efficacy and complication rate of PDL versus LPDL for treating childhood hemangiomas.
  
  
  METHODS
  We did a prospective, randomized, controlled trial in which we enrolled 52 Asian infants, aged 1-3 months, with early hemangiomas. These infants were assigned to PDL treatment (n = 26) or LPDL treatment (n = 26) and followed to age 1 year. A PDL with a wavelength of 585 nm and spot size of 7 mm and a LPDL with a wavelength of 595 nm and spot size of 7 mm were used. Each patient in the PDL group was treated with energy fluence between 6 and 7 J/cm(2) and a pulse duration of 0.45 milliseconds without epidermal cooling. Each patient in the LPDL group was treated with energy fluence between 9 and 15 J/cm(2) and a pulse duration of 10-20 milliseconds, utilizing CSC to protect the epidermis. Each group was treated at 4-week intervals until the lesion cleared. When each patient reached an age of 1 year, outcome measures such as clearance rate, time period of maximum proliferation, and complications were assessed.
  
  
  RESULTS
  The number of children whose lesions showed complete clearance or minimal residual signs at 1 year of age was 14 (54%) in the PDL group and 17 (65%) in the LPDL group (P = 0.397). Compared with the LPDL, PDL treated children had more hypopigmentation (3, 12% vs. 8, 31%; P = 0.001), more hyperpigmentation (2, 8% vs. 4, 15%; P = 0.005), and more textural changes (1, 4% vs. 6, 23%; P = 0.001). The average time period of maximum proliferation in the LPDL group was significantly shorter than that of the PDL group (106 days vs. 177 days; P = 0.01).
  
  
  CONCLUSIONS
  Early treatment of childhood hemangiomas with the LPDL is safer and more effective than the PDL.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Japan. tkono@prs.tmu.ac.jp
authors.forename: Taro
authors.initials: T
authors.lastname: Kono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakurai
authors.forename: William Frederick
authors.initials: WF
authors.lastname: Groff
authors.forename: Henry H
authors.initials: HH
authors.lastname: Chan
authors.forename: Masaki
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamaki
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Soejima
authors.forename: Motohiro
authors.initials: M
authors.lastname: Nozaki
mesh_terms: D044466:Asian People; D005260:Female; D006391:Hemangioma / Q000532:radiotherapy*; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology; D017496:Hypopigmentation / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome