title: [Study on the changes in the distribution and chemical states of the hepatic intra-and extra-cellular sodium ion in the rats with severe burns at early stage].
abstract: OBJECTIVE
  To investigate the changes in the distribution and chemical states of the hepatic intra- and extra-cellular sodium ion in the rats with severe burns, so as to provide guidance for fluid resuscitation at early postburn stage.
  
  
  METHODS
  Nineteen adult male Sprague-Dawley (SD) rats were employed in the study and were randomly divided into control (n = 12) and burn (n = 7) groups. The changes in the longitudinal (T1) and transverse (T2) relaxation times of hepatic intra-cellular and extra-cellular sodium in the two groups were studied with 23Na NMR spectroscopy and a shift reagent.
  
  
  RESULTS
  After infusion of the shift reagent,the extra-cellular sodium content in rat liver decreased by 17%, with obvious increase in fast T2 component (P < 0.01), indicating an increase in the fraction of Na+ binding sites in the extra-cellular space. The characteristics of relaxation of intra-cellular sodium remained unchanged despite a 57% increment in intra-cellular sodium content.
  
  
  CONCLUSIONS
  The deficiency of sodium as a permeable molecule might be related to the postburn movement of hypertonic sodium from extra-cellular to intra-cellular space. The results indicated that it is reasonable to administer high concentration of sodium in fluid resuscitation during the first 24 postburn hours.
authors.affiliation: Burn Center of PLA, Changhai Hospital, Second Military Medical University, Shanghai 200433, P. R. China.
authors.forename: Zhao-fan
authors.initials: ZF
authors.lastname: Xia
authors.forename: Jian-guang
authors.initials: JG
authors.lastname: Tian
authors.forename: Jie
authors.initials: J
authors.lastname: Xiong
authors.forename: Bing
authors.initials: B
authors.lastname: Ma
authors.forename: We
authors.initials: W
authors.lastname: Wei
authors.forename: Duo
authors.initials: D
authors.lastname: Wei
mesh_terms: D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology; D002412:Cations / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism*
chemical_list: D002412:Cations; D012964:Sodium