Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus.
Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4'- O- alpha-rhamnopyranoside, apigenin 7- O- beta-glucopyranosyl-4'- O- alpha-rhamnopyranoside, tricin 7- O- beta-glucopyranoside, tricin, and isoscopoletin possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.
Li
Haibo
H
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China.
Zhou
Changxin
C
Pan
Yunxue
Y
Gao
Xiaozhong
X
Wu
Xiumei
X
Bai
Hua
H
Zhou
Linfu
L
Chen
Zhi
Z
Zhang
Shuili
S
Shi
Shuyun
S
Luo
Jiali
J
Xu
Juanhua
J
Chen
Liurong
L
Zheng
Xiaoxiang
X
Zhao
Yu
Y
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004272:DNA, Mitochondrial; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D008517:Phytotherapy; D031947:Ranunculus / Q000737:chemistry*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004272:DNA, Mitochondrial; D005419:Flavonoids