title: Identification of the target self-antigens in reperfusion injury.
abstract: Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
authors.affiliation: CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Elisabeth M
authors.initials: EM
authors.lastname: Alicot
authors.forename: Isaac
authors.initials: I
authors.lastname: Chiu
authors.forename: Jinan
authors.initials: J
authors.lastname: Li
authors.forename: Nicola
authors.initials: N
authors.lastname: Verna
authors.forename: Thomas
authors.initials: T
authors.lastname: Vorup-Jensen
authors.forename: Benedikt
authors.initials: B
authors.lastname: Kessler
authors.forename: Motomu
authors.initials: M
authors.lastname: Shimaoka
authors.forename: Rodney
authors.initials: R
authors.lastname: Chan
authors.forename: Daniel
authors.initials: D
authors.lastname: Friend
authors.forename: Umar
authors.initials: U
authors.lastname: Mahmood
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder
authors.forename: Francis D
authors.initials: FD
authors.lastname: Moore
authors.forename: Michael C
authors.initials: MC
authors.lastname: Carroll
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity; D002199:Capillary Permeability; D006614:Hindlimb; D018398:Homeodomain Proteins / Q000235:genetics; D007113:Immunity, Innate; D007075:Immunoglobulin M / Q000276:immunology*; D007511:Ischemia; D007583:Jejunum / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000276:immunology / Q000473:pathology; D024507:Nonmuscle Myosin Type IIA / Q000276:immunology*; D015427:Reperfusion Injury / Q000276:immunology*
chemical_list: D001324:Autoantigens; D018398:Homeodomain Proteins; D007075:Immunoglobulin M; C064658:RAG-1 protein; D024507:Nonmuscle Myosin Type IIA