Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.
Endo
A
A
Fermentation Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140, Japan.
Kuroda
M
M
Tanzawa
K
K
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent / Q000737:chemistry*; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry / Q000494:pharmacology*; D010407:Penicillium / Q000737:chemistry*; D051381:Rats
D000924:Anticholesteremic Agents; D009284:Naphthols; C012258:mevastatin; C013749:ML 236A; D008148:Lovastatin; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent