Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology.
OBJECTIVE
the aim of the study was to investigate size control of amphiphilic beta-cyclodextrin nanoparticles obtained by solvent displacement technique.


METHODS
An experimental design methodology for mixture design was undertaken using D-optimal approach with the following technique variables: water fraction X1 (40-70% v/v), acetone fraction X2 (0-60% v/v) and ethanol fraction X3 (0-60% v/v).


RESULTS
The resulting quadratic model obtained after logarithmic transformation of data and partial least-square regression was statistically validated and experimentally checked. Also, the morphology of the colloidal nanoparticles from selected experiments was observed by cryo-transmission electron microscopy.


CONCLUSIONS
This experimental design approach allowed to produce interesting amphiphilic beta-cyclodextrin nanoparticles with a predicted mean size varying from 60 to 400 nm.
Choisnard
Luc
L
Université Joseph Fournier, UFR Pharmacie, DPM UMR CNRS 5063, Pharmacotechnie, Avenue de Verdun, Meylan Cedex. luc.choisnard@ujf-grenoble.fr
Géze
Annabelle
A
Bigan
Muriel
M
Putaux
Jean-Luc
JL
Wouessidjewe
Denis
D
D003505:Cyclodextrins / Q000138:chemical synthesis*; D015195:Drug Design; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D013678:Technology, Pharmaceutical / Q000379:methods*
D003505:Cyclodextrins