Influence of cardiopulmonary bypass on the state of cognitive functions in patients with ischemic heart disease.
Forty patients with ischemic heart disease and undergoing aortocoronary shunting surgery with cardiopulmonary bypass were studied. All patients were subjected to neuropsychological assessment and immunochemical analysis of the production of chemokines (IL-8, IP-10, MCP-1, MCP-3, MIP-1 beta, SDF-1 alpha) and cytokines (TNF-alpha and IL-10). The aims of the study were to assess the presence and severity of cognitive deficit developing after surgery with cardiopulmonary bypass and to assess the effects of intraoperative Trasylol on its severity. Cognitive deficit on day 9 after coronary shunting with cardiopulmonary bypass was seen as impairments of attention, hearing-speech memory, visual memory, and dynamic praxis. Trasylol had a marked neuroprotective effect and suppressed the systemic inflammatory response. Patients given intraoperative Trasylol had no clinically significant cognitive deficit in the early post-operative period.
Buziashvili
Yu I
YI
A. N. Bakulev Scientific Center for Cardiovascular Surgery, Russian Academy of Medical Sciences, Moscow.
Ambat'ello
S G
SG
Aleksakhina
Yu A
YA
Pashchenkov
M V
MV
D007611:Aprotinin / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D018925:Chemokines / Q000097:blood*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome
D018925:Chemokines; D018696:Neuroprotective Agents; D007611:Aprotinin