title: Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones.
abstract: A new class of oxazolidinone antibacterials incorporating oxygen-, nitrogen-, or sulfur-containing heterobicyclic C-rings is described. The in vitro potency and in vivo efficacy of these conformationally constrained oxazolidinone analogs are discussed.
authors.affiliation: Pfizer Global Research and Development, 34790 Ardentech Ct., Fremont, CA 94555, USA.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Renslo
authors.forename: Hongwu
authors.initials: H
authors.lastname: Gao
authors.forename: Priyadarshini
authors.initials: P
authors.lastname: Jaishankar
authors.forename: Revathy
authors.initials: R
authors.lastname: Venkatachalam
authors.forename: Marcela
authors.initials: M
authors.lastname: Gómez
authors.forename: Johanne
authors.initials: J
authors.lastname: Blais
authors.forename: Michael
authors.initials: M
authors.lastname: Huband
authors.forename: J V N
authors.initials: JV
authors.lastname: Vara Prasad
authors.forename: Mikhail F
authors.initials: MF
authors.lastname: Gordeev
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D051379:Mice; D008968:Molecular Conformation; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D023303:Oxazolidinones; D013438:Sulfhydryl Compounds