[Local thermotherapy with rabdosia liquid as prophylactic measure for recurrence of superficial urinary bladder carcinoma: a non-randomized contemporary controlled study].
OBJECTIVE
To compare the actions of local thermotherapy with rabdosia liquid and repeated perfusion of mitomycin C for the postoperative prophylaxis of superficial urinary bladder carcinoma.


METHODS
In the prospective non-randomized contemporary controlled study, 123 patients were divided into 2 groups. The patients in group A received local thermotherapy with rabdosia liquid starting from 1-2 months after operation, once tri-monthly for one year. Those in group B received intravesical perfusion of mitomycin C, starting from 2 weeks after operation, once weekly, six times in total, thereafter once monthly for one year. The recurrence rate, disease free interval, and adverse reaction after operation were observed.


RESULTS
The follow-up lasted for 10-45 months with the average of 28.6 +/- 5.8 months. The recurrence rates in group A and B were 5.0% and 14.3%, respectively. Significant difference was shown when compared by Kaplan-Meier analysis of disease free interval and the recurrence rate between the two groups (P < 0.05). The occurrence rates of cystitis, hematuria, vesical contracture, urethral stricture were 28.3%, 5.0%, 1.7%, 1.7%, respectively in group A, 25.4%, 4.8%, 0%, 0%, respectively in group B, showing no significant difference between the two groups (P > 0.05).


CONCLUSIONS
The effect of local thermotherapy with rabdosia liquid is reliable in preventing the recurrence of superficial urinary bladder transitional cell carcinoma.
Xu
Pei-yuan
PY
Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052. xupeiyuan_zheng-dauro@sina.com
Zhao
Gao-xian
GX
Chang
Lian-sheng
LS
D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000517:prevention & control / Q000601:surgery*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D037602:Isodon / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D008517:Phytotherapy; D011184:Postoperative Period; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms / Q000517:prevention & control / Q000601:surgery*
D004365:Drugs, Chinese Herbal