title: Clinicopathological features of melanocytic skin lesions in Egypt.
abstract: Although melanocytic skin lesions have been recognized since antiquity, their literature was limited to Caucasians. To date, the clinicopathologic features of these lesions in Egyptians are still unknown. To define these features, diagnostic records of the melanocytic skin lesions received at the Pathology Department, Assuit University Hospitals (1989-2004) were reviewed. The lesions examined included 12 benign naevi (BN), 10 dysplastic naevi (DN), and 21 cutaneous malignant melanomas (CMMs). The DN and CMMs were more common in men than in women (2 : 1 and 1.5 : 1, respectively) while BN were more common in women (2 : 1). The average age incidence was 33+/-5, 38+/-7 and 54+/-3 years, for BN, DN and CMM, respectively. The lower limb (13/21, 62%), head and neck (7/21, 33%) were the most common sites for CMMs. The average size (mm) was 2+/-0.3, 4+/-0.6 and 21+/-0.3 for BN, DN and CMMs, respectively. Recurrence occurred in 10% of CMMs. Histologically, CMMs were of nodular type and composed of epithelioid (7/21, 33%), spindle cells (1/21, 5%), or mixed cells (13/21, 62%). The mean tumour thickness (Breslow) was 6+/-0.5 mm. CMMs included two of 21(9%), three of 21(14%), six of 21(38%), and 10 of 21(38%) with Clark level II, III, IV and V. In Egypt, CMM is the third most common cutaneous neoplasm following squamous and basal cell carcinomas. Compared with Western societies, melanoma has a male sex predilection, similar histological features but different topographical distribution and rare incidence. The striking difference from Western series is the incidence of nodular melanoma - in the West this represents 15-30% of melanomas, with superficial spreading being the majority. Another key difference from the West is the 'sun-bed' culture of the West and the desire to have suntans. This is the first study that reports the clinicopathologic features of melanocytic skin lesions in Egypt.
authors.affiliation: Department of Pathology, Assuit University Hospitals, Faculty of Medicine, Assuit University, Assuit, Egypt. mrh17@swissinfo.org
authors.forename: Mahmoud R
authors.initials: MR
authors.lastname: Hussein
authors.forename: Dalia A
authors.initials: DA
authors.lastname: Elsers
authors.forename: Sabah A
authors.initials: SA
authors.lastname: Fadel
authors.forename: Abd-Elhady M
authors.initials: AE
authors.lastname: Omar
mesh_terms: D000328:Adult; D017677:Age Distribution; D018912:Arabs; D004416:Dysplastic Nevus Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects; D044465:White People