Adenoid basal epithelioma of the uterine cervix in 21-year-old patient. Report of a case with histologic and immunohistochemical study.
A case of adenoid basal epithelioma (ABE) of the uterine cervix in 21-year-old woman is reported. The patient's age appears to be lowest among cases of ABE reported to date. The tumor showed typical histologic features of ABE and was associated with CIN3. In addition, rare tumor cells had surface cilia-appearing structures suggesting tubal differentiation. Immunohistochemically, the tumor was reactive for p63, CD10, ER, PR, p16 and bcl-2, and negative for CEA. Thus, the immunophenotype also suggests possible partial tuboendometrioid differentiation in the glandular component of the lesion. It further indicates, along with finding of associated CIN, a role of oncogenic HPV in pathogenesis of ABE.
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Sikl's Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen, Czech Republic.
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D000328:Adult; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology