title: Temporal integration in nasal lateralization of ethanol.
abstract: Two experiments examined the trade-off between concentration and stimulus duration in nasal lateralization of n-ethyl alcohol. In nasal lateralization, a common measure of irritation threshold, subjects receive chemical vapor in one nostril and clean air in the other. Subjects try to determine which nostril received the chemical. Within experimental runs, subjects received fixed concentrations (1650-5000 ppm) of ethanol, and duration was varied to find the shortest, lateralizable stimulus. In Experiment 1, a small group of subjects was tested intensively to obtain stable individual data. In Experiment 2, a larger group was studied using more rapid methods. In both cases, subjects could lateralize increasingly weaker concentrations with longer stimulus presentations. Hence integration occurred. However, more than a twofold increase in duration was required to compensate for a twofold decrease in concentration to maintain threshold lateralization. These results suggest that an imperfect, mass-integrator model can describe short-term integration of nasal lateralization of ethanol.
authors.affiliation: Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104-3308, USA. pwise@monell.org
authors.forename: Paul M
authors.initials: PM
authors.lastname: Wise
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Canty
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Wysocki
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000502:physiology; D012684:Sensory Thresholds / Q000187:drug effects; D012903:Smell / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D000431:Ethanol