title: ShiBASE: an integrated database for comparative genomics of Shigella.
abstract: Among the major enteric bacterial pathogens, Shigella is found to display extreme genome diversity and dynamics, which imposes a challenge in comparative genomic studies. To facilitate further studies in this area, we have constructed an integrated online database, ShiBASE (http://www.mgc.ac.cn/ShiBASE/),which contains Shigella genomic sequences of four species and additional comparative genomic hybridization (CGH) data of 43 serotypes. ShiBASE offers online comparative analysis on DNA sequences, gene orders, metabolic pathways and virulence factors. In addition, ShiBASE has a newly developed online comparative visualization service, Shi-align, which enables the alignment of any query sequence with the reference genome sequences.
authors.affiliation: State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Lihong
authors.initials: L
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.forename: Lilian
authors.initials: L
authors.lastname: Sun
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
mesh_terms: D030561:Databases, Nucleic Acid; D016680:Genome, Bacterial; D023281:Genomics; D020407:Internet; D016415:Sequence Alignment; D012760:Shigella / Q000235:genetics*; D014584:User-Computer Interface