Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety.
Lee
Dongho
D
Laboratory of Anticancer Agents, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 305-333, Korea.
Lee
Kyeong
K
Cai
Xing Fu
XF
Dat
Nguyen Tien
NT
Boovanahalli
Shanthaveerappa K
SK
Lee
Mijeoung
M
Shin
Jin Chul
JC
Kim
Woncheol
W
Jeong
Jae Kap
JK
Lee
Jong Suk
JS
Lee
Choong-Hwan
CH
Lee
Jeong-Hyung
JH
Hong
Young-Soo
YS
Lee
Jung Joon
JJ
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry; D016227:Benzoquinones / Q000737:chemistry / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D047029:Lactams, Macrocyclic; D015394:Molecular Structure; D011809:Quinones / Q000737:chemistry / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D011809:Quinones; C001277:geldanamycin