Epithelioid malignant peripheral nerve sheath tumor involving maxillary sinus.
We present a case of epithelioid malignant peripheral nerve sheath tumor (MPNST) located in the maxillary sinus region in a young man. The clinical history was short, but at admission the neoplastic infiltration was so extensive that only diagnostic biopsy was performed. The patient received palliative treatment and died 6 months later. Histologically, the neoplasm had a predominant epithelioid component. Neoplastic tissue was vimentin, S-100, Cam 5.2 and neuron-specific enolase positive. P53 protein reaction was found in 6% of the cells and the proliferation index assessed with Ki-67 was 52%. An appropriate immunohistochemical panel was essential for the final diagnosis of this epithelioid malignant tumor, with the location rather unusual for MPNST.
Izycka-Swieszewska
Ewa
E
Department of Pathology, Medical University of Gdansk, Debinki 7 str, 80-211 Gdansk, Poland. eczis@wp.pl
Drogoszewska
Barbara
B
Filipowicz
Joanna
J
Szurowska
Edyta
E
Kaminski
Maciej
M
Jaskiewicz
Kazimierz
K
D000328:Adult; D002277:Carcinoma / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000378:metabolism / Q000473:pathology*; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology*