Chemotherapy-induced amenorrhea from adjuvant breast cancer treatment: the effect of the addition of taxanes.
OBJECTIVE
Adjuvant chemotherapy for breast cancer can be associated with a variety of side effects, one of which is the induction of premature menopause in premenopausal patient. Although taxanes have increasingly been used in the adjuvant setting, there has been relatively little published on the frequency of amenorrhea related to their use.


METHODS
We review records of 159 premenopausal patients receiving adjuvant chemotherapy from our practice.


RESULTS
Altogether, 51% of all patients retained menstrual function after chemotherapy.


CONCLUSIONS
It was observed that patients receiving adjuvant anthracycline-based chemotherapy with sequential taxane therapy did not have a higher rate of amenorrhea than those not receiving a taxane.
Davis
Amy L
AL
Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, USA.
Klitus
Matthew
M
Mintzer
David M
DM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000568:Amenorrhea / Q000139:chemically induced*; D018943:Anthracyclines / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects*; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D013629:Tamoxifen / Q000627:therapeutic use; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
D018943:Anthracyclines; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D013629:Tamoxifen; D017239:Paclitaxel