title: Recurrent primary plasmacytoma of the eyelid with rapid regional metastasis.
abstract: In this case, originally reported as primary eyelid plasmacytoma, the tumor recurred on the same eyelid within 2 years of surgery. No plasma cell infiltration was observed at bone marrow biopsy. No serum or urinary monoclonal component was detected at immunofixation. Histology and immunohistochemistry confirmed plasma cell infiltration. Tumor cell clonality was determined by immunohistological staining; cells were positive for kappa light chain like the first eyelid tumor. Surgery was followed by radiotherapy. Twenty months later, biopsy of one enlarged right cervical lymph node showed massive diffuse infiltration of atypical plasma cells (CD20(-), CD79a(+), CD138(+), MUM1/IRF4(+)). Given the rapid diffusion to lymph nodes and the appearance of the monoclonal component, the lymph node was removed surgically. No adjuvant chemotherapy was given. Unexpectedly, the serum monoclonal component normalized. No plasma cell infiltration was observed at bone marrow biopsy. As this case might be a particularly slow-progressing extra-medullary plasmacytoma, this study recommends closely monitored follow-ups so that the aggressive form can be treated in time.
authors.affiliation: Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ria
authors.forename: M
authors.initials: M
authors.lastname: Di Ianni
authors.forename: P
authors.initials: P
authors.lastname: Sportoletti
authors.forename: M
authors.initials: M
authors.lastname: Cimminiello
authors.forename: L
authors.initials: L
authors.lastname: Marcomigni
authors.forename: A
authors.initials: A
authors.lastname: Tabilio
mesh_terms: D000328:Adult; D001706:Biopsy; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D010954:Plasmacytoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012074:Remission Induction; D016896:Treatment Outcome