title: Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.
abstract: Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. Moreover, TPase, identified also as the angiogenic platelet-derived endothelial cell growth factor (PD-ECGF), stimulates endothelial cell migration in vitro and angiogenesis in vivo and plays an important role in tumour progression and metastasis. Here we have summarized the most recent approaches in the search for novel TPase inhibitors together with the potential therapeutic applications of such inhibitors.
authors.affiliation: Instituto de Química Médica (CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain. mjperez@iqm.csic.es
authors.forename: María-Jesús
authors.initials: MJ
authors.lastname: Pérez-Pérez
authors.forename: Eva-María
authors.initials: EM
authors.lastname: Priego
authors.forename: Ana-Isabel
authors.initials: AI
authors.lastname: Hernández
authors.forename: María-José
authors.initials: MJ
authors.lastname: Camarasa
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Sandra
authors.initials: S
authors.lastname: Liekens
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001665:Binding Sites; D015195:Drug Design; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D016228:Endothelial Growth Factors; D004791:Enzyme Inhibitors; D014498:Uracil; C013400:6-aminouracil; D013939:Thymidine Phosphorylase