Anti-Müllerian hormone: a new marker for ovarian function.
Anti-Müllerian hormone (AMH) is a member of the transforming growth factor beta family of growth and differentiation factors. In the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growing follicles to follicle-stimulating hormone (FSH). The ovary-specific expression pattern in granulosa cells of growing nonselected follicles makes AMH an ideal marker for the size of the ovarian follicle pool. This review summarizes recent findings concerning AMH and its role as a marker for the quantitative aspect of ovarian reserve as well as ovarian dysfunction.
Visser
Jenny A
JA
Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands. j.visser@erasmusmc.nl
de Jong
Frank H
FH
Laven
Joop S E
JS
Themmen
Axel P N
AP
D000375:Aging / Q000097:blood; D054304:Anti-Mullerian Hormone; D015415:Biomarkers / Q000097:blood; D005260:Female; D005298:Fertility / Q000502:physiology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D010049:Ovarian Diseases / Q000175:diagnosis; D010053:Ovary / Q000502:physiology*; D017697:Premenopause / Q000097:blood*; D013735:Testicular Hormones / Q000097:blood*
D015415:Biomarkers; D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone