Use of serum carbohydrate-deficient transferrin values to exclude alcoholic hepatitis from non-alcoholic steatohepatitis: a pilot study.
BACKGROUND
Since no clinical or biochemical parameters allow an accurate diagnosis of non-alcoholic steatohepatitis (NASH), the diagnosis by exclusion of alcoholic hepatitis is necessary. However, it is difficult to get the accurate amount of alcohol consumed from the patients, especially from females. To differentiate between NASH and alcoholic hepatitis, we investigated whether serum biochemical markers of chronic alcohol abuse are useful or not.


METHODS
Sera were obtained from 13 patients with NASH and 26 patients with alcoholic hepatitis. Diagnoses in these patients were confirmed histologically by needle biopsy of the liver. All patients with alcoholic hepatitis consumed more than 80 g of ethanol/day for more than 10 years. As markers of chronic alcohol abuse, serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), hyaluronate, mean corpuscular volume of red blood cells (MCV) and carbohydrate-deficient transferrin (CDT) were measured.


RESULTS
Among alcohol markers, serum values of AST, AST/ALT ratio, GGT, CDT and MCV in patients with alcoholic hepatitis were significantly higher than those in patients with NASH, respectively. However, serum values of these markers, except for CDT, were overlapped in many cases of NASH and alcoholic hepatitis. Serum CDT values of all patients with NASH were lower than the cutoff value, 2.66%, and those of all patients with alcoholic hepatitis were higher than the cutoff value.


CONCLUSIONS
The results of the present study suggest that serum CDT level could be used to differentiate between NASH and alcoholic hepatitis.
Ohtsuka
Toshimi
T
Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan.
Tsutsumi
Mikihiro
M
Fukumura
Atsushi
A
Tsuchishima
Mutsumi
M
Takase
Shujiro
S
D015415:Biomarkers; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006526:Hepatitis C / Q000473:pathology / Q000821:virology; D006519:Hepatitis, Alcoholic / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism
D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin