[Analysis of cardiac parameters in animals with epilepsy: possible cause of sudden death?].
Among the causes for sudden death in epilepsy, cardiac dysfunction has been an area of interest. Based on this, the aim of our study was to evaluate the heart rate (in vivo and in vitro) and ventricular pressure in vitro of rats with epilepsy induced by pilocarpine. Adult male Wistar rats (n=6) were given pilocarpine hydrochloride to induce status epilepticus. Control rats (n=6) received saline solution instead pilocarpine. Our results showed significant differences in the mean of heart rate in vivo between the groups. In contrast, we did not find differences during in vitro experiments. Our results suggest a central nervous system modulation on the heart, which could explain the sudden unexpected death in epilepsy.
Colugnati
Diego Basile
DB
Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brasil.
Gomes
Paulo Alberto Paes
PA
Arida
Ricardo Mario
RM
de Albuquerque
Marly
M
Cysneiros
Roberta Monterazzo
RM
Cavalheiro
Esper Abrão
EA
Scorza
Fulvio Alexandre
FA
D000818:Animals; D003645:Death, Sudden / Q000209:etiology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology*; D008297:Male; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D017725:Ventricular Pressure / Q000502:physiology*
D010862:Pilocarpine