title: Genetics of restless legs syndrome.
abstract: Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.
authors.affiliation: Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
authors.forename: Ignacio F
authors.initials: IF
authors.lastname: Mata
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Bodkin
authors.forename: Charles H
authors.initials: CH
authors.lastname: Adler
authors.forename: Siong-Chi
authors.initials: SC
authors.lastname: Lin
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
mesh_terms: D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D012148:Restless Legs Syndrome / Q000453:epidemiology / Q000235:genetics*