Control of transcription through intragenic patterns of nucleosome composition.
Several recent papers show that differences in histone modification and the use of histone variants at the 5' and 3' ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls access to DNA at specific genomic locations.
Lieb
Jason D
JD
Department of Biology and the Carolina Center for Genome Sciences, 202 Fordham Hall, CB 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jlieb@bio.unc.edu
Clarke
Neil D
ND
D000818:Animals; D004247:DNA / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008745:Methylation; D009707:Nucleosomes / Q000737:chemistry / Q000502:physiology*; D012441:Saccharomyces cerevisiae; D024363:Transcription Initiation Site / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
D006657:Histones; D009707:Nucleosomes; D004247:DNA