Burn-induced alterations of chromium and the glucose/insulin system in rats.
Our objective was to demonstrate a role of chromium (Cr) in response to severe burn. A third-degree burn involving 20% of total body surface was applied under anaesthesia in accord with ethical guidelines. Chromium concentrations in liver decreased progressively and were non-detectable on days 5 and 10 following injury. In quadriceps muscle, Cr concentrations increased 6h after injury and then declined significantly within the first day and remained at these levels the following 9 days. Urinary Cr losses were also increased. Changes in kidney, brain and serum Cr were not significant. Non-fasting glucose rose 6h after injury and then returned to levels measured before the burn. There was a significant rise in corticosterone reaching a maximum the first day after injury that was accompanied by significant increases in circulating insulin and glucagon that were maximal after 2 days. Changes in IGF-1 were not significant. In summary, changes in Cr concentrations were associated with an early hyperglycemia, hyperinsulinemia and increased secretion of stress hormones. These observations strongly suggest a mobilization and utilization of Cr following severe burn. Additional studies are needed to document that improved Cr status might lead to improved recovery following burn.
Anderson
Richard A
RA
Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, Agriculture Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA. AndersonR@ba.ars.usda.gov
Sandre
Caroline
C
Bryden
Noella A
NA
Agay
Diane
D
Chancerelle
Yves
Y
Polansky
Marilyn M
MM
Roussel
Anne-Marie
AM
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002056:Burns / Q000150:complications / Q000378:metabolism*; D002857:Chromium / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism; D006943:Hyperglycemia / Q000209:etiology; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007328:Insulin; D002857:Chromium; D007334:Insulin-Like Growth Factor I; D005934:Glucagon; D003345:Corticosterone