title: The efficacy of multiple courses of alefacept in patients with moderate to severe chronic plaque psoriasis.
abstract: Among patients with psoriasis who did not achieve Psoriasis Area and Severity Index 50 during the first course of alefacept therapy, 53% achieved Psoriasis Area and Severity Index 50 during the second course (odds ratio [95% confidence interval] vs placebo 2.30 [1.26-4.19]). Alefacept provided incremental efficacy over 5 successive 12-week treatment courses.
authors.affiliation: Baylor University Medical Center, Dallas, Texas, USA. amresearch@texasderm.com
authors.forename: Alan
authors.initials: A
authors.lastname: Menter
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Cather
authors.forename: Diane
authors.initials: D
authors.lastname: Baker
authors.forename: Harold F
authors.initials: HF
authors.lastname: Farber
authors.forename: Mark
authors.initials: M
authors.lastname: Lebwohl
authors.forename: Mohamed
authors.initials: M
authors.lastname: Darif
mesh_terms: D000077944:Alefacept; D002908:Chronic Disease; D017326:Clinical Trials, Phase III as Topic; D004334:Drug Administration Schedule; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D019233:Retreatment; D012720:Severity of Illness Index; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D011993:Recombinant Fusion Proteins; D000077944:Alefacept