Determination of 112 halogenated pesticides using gas chromatography/mass spectrometry with selected ion monitoring.
A procedure for the analysis of 112 halogenated pesticides that do not contain phosphorus has been developed. The procedure uses gas chromatography with a mass selective detector (GC-MSD), electron impact ionization, and selected-ion monitoring. This GC-MSD procedure provided lower limits of quantitation and provided increased confirmational data compared to the traditional element-selective GC procedures that are commonly used for the detection of this class of pesticides. These analytical improvements were demonstrated by the 25 pesticides that were detected at < or =50 ng/g levels in a variety of fruit and vegetable matrixes using this procedure that were missed by the traditional element selective GC procedures. Validation of the procedure was performed using 20 representative target pesticides with an acetone extraction and a solid-phase extraction cleanup. These target pesticides were used to demonstrate repeatability and linearity of the chromatographic response and recovery from fruit and vegetable matrixes.
Mercer
Gregory E
GE
U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Dr SE, Bothell, WA 98021, USA. greg.mercer@fda.gov
D002212:Capsicum / Q000737:chemistry; D018552:Daucus carota / Q000737:chemistry; D004784:Environmental Monitoring / Q000379:methods* / Q000592:standards; D005506:Food Contamination / Q000032:analysis*; D031985:Fragaria / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D018545:Lactuca / Q000737:chemistry; D010575:Pesticides / Q000032:analysis* / Q000145:classification*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D010575:Pesticides