Viruses and lymphoma.
The aetiology of lymphomas is poorly understood and the striking increase in its incidence rate in developed societies remains unexplained. The concept of lymphoma as a virally-induced malignancy is not surprising since viruses are implicated in approximately 15% of all cancers. However, lymphoma represents a complex multistep process and, although viral associations have been identified, integration of the available epidemiological and scientific data poses substantial questions. The study of oncogenic viruses has and will continue to yield major insights into the pathogenesis of lymphoma. Further research is likely to uncover new lymphoma associations between both known and as yet unidentified viruses, may provide cellular and pharmacological targeted antiviral therapy strategies for the treatment of malignant lymphoma, and ultimately may generate the most promising avenue for lymphoma prevention.
Gandhi
Maher K
MK
Tumour Immunology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. maherG@qimr.edu.au
Khanna
Rajiv
R
D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000821:virology*; D009858:Oncogenic Viruses / Q000472:pathogenicity*; D014412:Tumor Virus Infections