Interindividual variability in the absorption of ciprofloxacin and hydrocortisone from continent ileal reservoir for urine.
OBJECTIVE
The neobladder created with a detubularized segment of ileum as standard treatment for the transitional cell carcinoma of the bladder may permit absorption of drugs. As a consequence, on the one hand the elimination of drugs excreted in the urine may be delayed and a change of dosage may be required, and on the other hand the intravesical administration of a drug may produce blood levels capable of inducing unwanted systemic effects. The purpose of the present study was to explore the possibility of drug absorption from a continent ileal reservoir for urine.


METHODS
The possibility of drug re-absorption from a continent ileal reservoir for urine was studied in 12 patients with well functioning reservoirs after a time interval of 3 months from surgery and also, in 7 of them, 6 months later. Saline solutions of ciprofloxacin or hydrocortisone were instilled and maintained in the reservoir for 2 h, and drug concentrations in plasma were measured 1 and 2 h after instillation.


RESULTS
Both ciprofloxacin and to a lower extent hydrocortisone were adsorbed from the reservoir, but with large interindividual variability. A comparison of the plasma concentrations produced by the two drugs 3 and 9 months after creation of the new bladder revealed that after 9 months the absorption was decreased in 3 patients, substantially unchanged in 2, and increased in 2.


CONCLUSIONS
The results of this study show that both ciprofloxacin, chosen for its use as possible radiosensitizing agent in bladder cancer patients, and hydrocortisone, chosen as an example of lypofilic endogenous compound, can be absorbed through the intestinal mucosa of a continent ileal reservoir, but to a different extent and with high interindividual variability.
Mattioli
F
F
Department of Internal Medicine, Pharmacology and Toxicology Unit, University of Genoa, 16132, Genoa, Italy.
Tognoni
P
P
Manfredi
V
V
Gosmar
M
M
Corbu
C
C
Garbero
C
C
Martelli
A
A
D000283:Administration, Intravesical; D000368:Aged; D000704:Analysis of Variance; D002295:Carcinoma, Transitional Cell / Q000601:surgery; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000493:pharmacokinetics*; D007082:Ileum / Q000378:metabolism* / Q000601:surgery; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000601:surgery; D014547:Urinary Diversion; D016476:Urinary Reservoirs, Continent
D002939:Ciprofloxacin; D006854:Hydrocortisone