Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis.
In the present study, we evaluated antimicrobial activity of clove oil against a range of fungal pathogens including that responsible for urogenital infection. Clove oil was found to possess strong antifungal activity against opportunistic fungal pathogens such as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, etc. The oil was found to be extremely successful in the treatment of experimental murine vaginitis in model animals. On evaluating various formulations, topical administration of the liposomized clove oil was found to be most effective against treatment of vaginal candidiasis.
Ahmad
N
N
Faculty of Pharmacy, Jamia Hamdard, New-Delhi, India.
Alam
M K
MK
Shehbaz
A
A
Khan
A
A
Mannan
A
A
Hakim
S Rashid
SR
Bisht
D
D
Owais
M
M
D000282:Administration, Intravaginal; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D045783:Clove Oil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003455:Cryptococcus neoformans / Q000187:drug effects; D004655:Emulsions; D005260:Female; D008081:Liposomes; D051379:Mice; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D045783:Clove Oil; D004655:Emulsions; D008081:Liposomes