Peroxisome proliferator-activated receptor gamma in malignant diseases.
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) belongs to the family of nuclear hormone receptors (NHRs) and is a ligand-activated transcription factor. There are four mRNAs, PPAR-gamma1, PPAR-gamma2, PPAR-gamma3 and PPAR-gamma4, which encode two proteins, PPAR-gamma1and PPAR-gamma2. PPAR-gamma consists of five or six structural regions (A-F) in four functional domains. The NH2-terminal A/B domain harbors a ligand-independent transcriptional activation function (AF-1), the C domain is a DNA binding domain (DBD), the D hinge region is important for co-factor docking and the complex multifunctional COOH-terminal portion (E/F) encompasses the ligand binding domain (LBD), a dimerization interface and the ligand-dependent activation domain AF-2. Some long-chain polyunsaturated fatty acids, arachidonic acid metabolites and fatty acid derived components are natural ligands of PPAR-gamma. The anti-diabetic thiazolidinedione class of drugs, certain non-steroidal anti-inflammatory drugs (NSAIDs) and some non-thiazolidinedione tyrosine are the synthetic ligands of PPAR-gamma. After activation, it forms heterodimer with the retinoid X receptor (RXR) and then binds to specific recognition sites in the target gene, the peroxisome proliferator response elements (PPREs), and regulates transcription of specific genes. PPAR-gamma has potential anti-neoplastic effects both in solid cancer and in leukemia through inhibition of cell proliferation, induction of apoptosis and terminal differentiation, as well as inhibition of angiogenesis. The ligands of PPAR-gamma may represent a promising, novel therapeutic approach for certain human malignancies.
Wang
Tingting
T
State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China.
Xu
Jian
J
Yu
Xiaofei
X
Yang
Renchi
R
Han
Zhong Chao
ZC
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism
D047495:PPAR gamma