title: Ketorolac tromethamine liposomes: encapsulation and release studies.
abstract: Liposomes loaded with ketorolac tromethamine salt were prepared by using a thin layer evaporation method. The physical properties of liposomes were studied by using atomic force microscopy (AFM) and transmission electron microscopy (TEM). The relationship between lipid composition, encapsulation efficiency, vesicle size, and the release of ketorolac tromethamine-loaded liposomes was studied. The drug content was found to be dependent on the lipidic composition used in the preparations and, in particular, vesicles containing both cationic lipids (dimethyldioctadecylammonium bromide and N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride), and phosphatidylcholine had a higher entrapped efficiency than liposomes with phosphatidylcholine alone or in the presence of cholesterol. Finally, the cationic liposomes appear to be useful as carriers for ketorolac tromethamine to control its in vitro release.
authors.affiliation: Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ruozi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tosi
authors.forename: Flavio
authors.initials: F
authors.lastname: Forni
authors.forename: Maria
authors.initials: M
authors.lastname: Angela Vandelli
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry; D004339:Drug Compounding; D006801:Humans; D020911:Ketorolac Tromethamine / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D010316:Particle Size
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D008081:Liposomes; D020911:Ketorolac Tromethamine