title: Accelerator mass spectrometry for biomedical research.
abstract: Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of (14)C- and (3)H-labeled compounds in various experiment types.
authors.affiliation: Lawrence Livermore National Laboratory, Livermore, California, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Brown
authors.forename: Karen H
authors.initials: KH
authors.lastname: Dingley
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Turteltaub
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes / Q000032:analysis; D004247:DNA / Q000032:analysis*; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods*; D010315:Particle Accelerators / Q000295:instrumentation; D011506:Proteins / Q000032:analysis*; D014316:Tritium / Q000032:analysis
chemical_list: D002250:Carbon Radioisotopes; D011506:Proteins; D014316:Tritium; D004247:DNA