title: A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations.
abstract: BACKGROUND
  Low level laser therapy (LLLT) has gained increasing popularity in the management of tendinopathy and arthritis. Results from in vitro and in vivo studies have suggested that inflammatory modulation is one of several possible biological mechanisms of LLLT action.
  
  
  OBJECTIVE
  To investigate in situ if LLLT has an anti-inflammatory effect on activated tendinitis of the human Achilles tendon.
  
  
  METHODS
  Seven patients with bilateral Achilles tendinitis (14 tendons) who had aggravated symptoms produced by pain inducing activity immediately before the study.
  
  
  METHODS
  Infrared (904 nm wavelength) LLLT (5.4 J per point, power density 20 mW/cm2) and placebo LLLT (0 J) were administered to both Achilles tendons in random blinded order.
  
  
  RESULTS
  Ultrasonography Doppler measurements at baseline showed minor inflammation through increased intratendinous blood flow in all 14 tendons and measurable resistive index in eight tendons of 0.91 (95% confidence interval 0.87 to 0.95). Prostaglandin E2 concentrations were significantly reduced 75, 90, and 105 minutes after active LLLT compared with concentrations before treatment (p = 0.026) and after placebo LLLT (p = 0.009). Pressure pain threshold had increased significantly (p = 0.012) after active LLLT compared with placebo LLLT: the mean difference in the change between the groups was 0.40 kg/cm2 (95% confidence interval 0.10 to 0.70).
  
  
  CONCLUSIONS
  LLLT at a dose of 5.4 J per point can reduce inflammation and pain in activated Achilles tendinitis. LLLT may therefore have potential in the management of diseases with an inflammatory component.
authors.affiliation: Physiotherapy Science, University of Bergen, Bergen, Norway. jmbjor@broadpark.no
authors.forename: J M
authors.initials: JM
authors.lastname: Bjordal
authors.forename: R A B
authors.initials: RA
authors.lastname: Lopes-Martins
authors.forename: V V
authors.initials: VV
authors.lastname: Iversen
mesh_terms: D000125:Achilles Tendon / Q000000981:diagnostic imaging / Q000378:metabolism; D000328:Adult; D015232:Dinoprostone / Q000378:metabolism*; D004311:Double-Blind Method; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods*; D017551:Microdialysis / Q000379:methods; D008875:Middle Aged; D010147:Pain Measurement; D052256:Tendinopathy / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D015232:Dinoprostone