Mass-dependent decline of skeletal muscle function in cancer cachexia.
CD2F1 mice were inoculated with C26 adenocarcinoma cells, followed by assessment of ex vivo muscular function. Muscles from tumor-bearing mice had a significantly lower force output during a single maximal contraction and during repeated contractions than control muscles. The relative force output, however, did not differ when corrected for muscle mass. Thus, cachexia significantly reduces absolute skeletal muscle function, but muscle "quality" appears unaltered.
Gorselink
Marchel
M
Numico Research, Department of BioMedical Research, Bosrandweg 20, 6704 PH Wageningen, The Netherlands. Marchel.Gorselik@Numeco-research
Vaessen
Stefan F C
SF
van der Flier
Laurens G
LG
Leenders
Inge
I
Kegler
Diane
D
Caldenhoven
Eric
E
van der Beek
Eline
E
van Helvoort
Ardy
A
D000230:Adenocarcinoma / Q000150:complications*; D000704:Analysis of Variance; D000818:Animals; D002100:Cachexia / Q000209:etiology*; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology* / Q000528:radiation effects; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009374:Neoplasms, Experimental; D013997:Time Factors