[Effect of albumin on frequency of spontaneous mutations in somatic mammalian cells in vitro].
Human albumin is able to induce statistically significant increasing of the frequency of spontaneous mutations in the hprt locus in cultured somatic mammalian cells. The strait dependence of the mutagenic effect on the protein concentration has been shown. The products of albumin degradation reveal antimutagenic activity in the investigated test-system.
Kovalenko
O O
OO
Kostets'kyĭ
I Ie
IIe
Lukash
L L
LL
D000418:Albumins / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*
D000418:Albumins; D007041:Hypoxanthine Phosphoribosyltransferase