Hemodynamic effects of di-sec-butyl phenol, an anesthetic substituted phenol.
Dose- and age-related hemodynamic effects were determined for an anesthetic substituted phenol, 2,6-di-sec-butyl phenol (DSB). DSB, 7.5 mg/kg, induced hypnosis in young rabbits and increased mean blood pressure to 170 +/- 14% and heart rate to 150 +/- 21% of control values. In elderly rabbits, 7.5 mg/kg DSB induced hypnosis, had no effect on blood pressure, but increased the heart rate to 130 +/- 2% of control. After ganglionic blockade with hexamethonium, 7.5 mg/kg DSB caused a decline in mean blood pressure (71 +/- 5% of control) without change in heart rate. DSB increased norepinephrine release from SH-SY5Y cells, a human neuroblastoma cell line (5.4 +/- 1.7% vs. 3.5 +/- 0.3%). DSB produced age-dependent elevation of mean blood pressure in rabbits, probably by causing release of catecholamines from the sympathetic nervous system.
Ya Deau
Jacques T
JT
Hospital for Special Surgery, Weill Medical College, Cornell University, New York, NY 10021, USA. yadeauj@hss.edu
Heerdt
Paul M
PM
The
Andrew H S
AH
Wang
Qingwen
Q
D000367:Age Factors; D000777:Anesthetics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002073:Butanes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005730:Ganglionic Blockers / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D018738:Hexamethonium / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous; D009638:Norepinephrine / Q000378:metabolism; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors; D014316:Tritium
D000777:Anesthetics; D002073:Butanes; D005730:Ganglionic Blockers; D010636:Phenols; C509539:di-sec-butyl phenol; D014316:Tritium; D018738:Hexamethonium; D011188:Potassium; D009638:Norepinephrine; D004121:Dimethyl Sulfoxide