title: Eosinophilic cytoplasmic inclusions in papillary renal cell carcinoma.
abstract: A case of a patient with papillary renal cell carcinoma (RCC) with eosinophilic inclusions is presented. Almost all neoplastic cells contained eosinophilic globules that were stained red by trichrome and were negative for periodic acid-Schiff (PAS) reaction. Immunohistochemically, globules were negative for actin, keratin, vimentin, glially fibrillary acidic protein (GFAP), and neurofilament. Ultrastructurally, globules consisted of electron-dense granular material that is more suggestive of a secretory substance than cytoskeletal filaments. The presence of eosinophilic cytoplasmic inclusions in RCC is rare. In this article, we review similar cases in the literature and discuss the nature of eosinophilic globules.
authors.affiliation: Department of Pathology II, Kansai Medical University, Moriguchi, Osaka, 570-8506, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Danbara
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shikata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shintaku
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura
mesh_terms: D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000648:ultrastructure; D004804:Eosinophils / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology* / Q000648:ultrastructure; D007564:Japan; D007680:Kidney Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D008297:Male