Trichosporon pullulans as a complication of chronic granulomatous disease in a patient undergoing immunosuppressive therapy for inflammatory bowel disease.
We describe a patient with chronic granulomatous disease and receiving immunosuppressive therapy for refractory granulomatous colitis who developed fatal fulminant pneumonia, with Trichosporon pullulans isolated from multiple sites. This case highlights potential difficulties in treating chronic granulomatous disease colitis with high dose immunosuppressants and suggests that T. pullulans may represent an opportunistic organism with high morbidity and mortality in such patients.
Lestini
Brian J
BJ
General Pediatrics, Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
Church
Joseph A
JA
D000328:Adult; D017809:Fatal Outcome; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009181:Mycoses / Q000150:complications* / Q000382:microbiology; D011014:Pneumonia / Q000150:complications* / Q000382:microbiology; D014250:Trichosporon / Q000302:isolation & purification*
D007166:Immunosuppressive Agents