Epoxide hydrolases: structure, function, mechanism, and assay.
Epoxide hydrolases are a class of enzymes important in the detoxification of genotoxic compounds, as well as in the control of physiological signaling molecules. This chapter gives an overview on the function, structure, and enzymatic mechanism of structurally characterized epoxide hydrolases and describes selected assays for the quantification of epoxide hydrolase activity.
Arand
Michael
M
Institut fuer Pharmakologie und Toxikologie, Universitaet Wuerzburg, Germany.
Cronin
Annette
A
Adamska
Magdalena
M
Oesch
Franz
F
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D004851:Epoxide Hydrolases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008658:Inactivation, Metabolic; D015394:Molecular Structure; D017510:Protein Folding; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D013229:Stearic Acids / Q000032:analysis / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism
D011994:Recombinant Proteins; D013229:Stearic Acids; D015262:Xenobiotics; C013519:9,10-epoxystearic acid; D004851:Epoxide Hydrolases; C043134:leukotriene A4 hydrolase