title: Inhibition of preadipocyte differentiation by germacranolides from Calea urticifolia in 3T3-L1 cells.
abstract: The effects of germacranolides isolated from Calea urticifolia on adipocytic differentiation of 3T3-L1 cells were examined. These germacranolides inhibited adipogenesis at a concentration of 1.25-5 microM. But no inhibitory activity against cell proliferation and no nonspecific binding activity to protein were observed. These results indicate that these germacranolides are the specific inhibitors of preadipocyte differentiation.
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, Japan. nobuyasu@dis.ous.ac.jp
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamada
authors.forename: Hiroto
authors.initials: H
authors.lastname: Suzuki
authors.forename: Naoko
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kurosaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Ubukata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
mesh_terms: D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects*; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D050356:Lipid Metabolism; D051379:Mice; D045788:Sesquiterpenes, Germacrane / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects*
chemical_list: D045788:Sesquiterpenes, Germacrane; C432449:germacranolide