title: Aspergillus flavus scleritis: successful treatment with voriconazole and caspofungin.
abstract: Aspergillus scleritis is a potentially devastating ocular infection difficult to treat because of poor scleral vascularity. Most Aspergillus cases occur following ocular surgery, but others have been associated with trauma or intravenous drug use. No anti-fungal agents are consistently efficacious in the treatment of scleral fungal infections. We report a case of Aspergillus scleritis successfully treated with a combination of voriconazole and caspofungin, as well as a review of the literature concerning treatment of Aspergillus scleritis.
authors.affiliation: Department of Internal Medicine, Division of Infectious Disease, Scott & White Memorial Hospital and Clinic, Temple, Texas 76508, USA. ahowell@swmail.sw.org
authors.forename: Alan
authors.initials: A
authors.lastname: Howell
authors.forename: John
authors.initials: J
authors.lastname: Midturi
authors.forename: Miguel
authors.initials: M
authors.lastname: Sierra-Hoffman
authors.forename: John
authors.initials: J
authors.lastname: Carpenter
authors.forename: Douglas
authors.initials: D
authors.lastname: Hurley
authors.forename: Richard
authors.initials: R
authors.lastname: Winn
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy*; D001231:Aspergillus flavus; D000077336:Caspofungin; D054714:Echinocandins; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D015423:Scleritis / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole