title: Renal transplantation from non-heart-beating donors: a single-center 10-year experience.
abstract: BACKGROUND
  Reluctance to accept non-heart-beating donors (NHBD) as a source of kidneys, is due to medical, ethical, and logistical reasons. Evidence suggest that the short-term graft survival is similar to that of kidneys obtained from heart-beating donors (HBD). However, few studies, with long-term follow-up are available. We conducted a single-center study of kidneys obtained from NHBD, in a 14-year period.
  
  
  METHODS
  We studied 100 patients transplanted with kidneys between 1989 and 2004, using NHBD, supported by heart compression and mechanical ventilation (n = 24), intravascular in situ cooling (n = 59), or cardiorespiratory resuscitation plus manual abdominal counterpulsation without cooling (n = 17), the last technique being used from 1998. The median follow-up was 51 +/- 51 months (range, 1 to 170). The outcomes of these procedures were compared to those of 1025 transplantations of kidneys from HBD performed during the same period.
  
  
  RESULTS
  The characteristics of the recipients did not differ significantly between the two groups. Kidneys from NHBD showed a significantly higher rate of delayed graft function (DGF; 84% vs 26%; (P < .001), furthermore, the primary nonfunction (PNF) incidence was significantly higher with NHBD vs HBD (16% vs 10%; P < .001). The incidence of acute rejection episodes (ARE) within 3 months and at 1 year did not differ between the groups of donors; however, more NHBD kidneys were lost from ARE. The short-term (3-month and 1 year) and long-term (5 and 10 years) renal function, determined by the serum creatinine levels, and patient and graft survival were not different for kidneys obtained from NHBD.
  
  
  CONCLUSIONS
  The incidences of PNF and DGF were significantly higher with NHBD, which produced poorer renal function at the time of hospital discharge. One-, 5-, and 10-year graft survivals and renal function did not differ between NHBD and HBD grafts. In our series, PNF was the main barrier to the use of NHBD.
authors.affiliation: Servicio de Nefrología, CHU Juan Canalejo, A Coruña, Spain. angel_alonso@canalejo.org
authors.forename: A
authors.initials: A
authors.lastname: Alonso
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Rivera
authors.forename: P
authors.initials: P
authors.lastname: Villaverde
authors.forename: J
authors.initials: J
authors.lastname: Oliver
authors.forename: S
authors.initials: S
authors.lastname: Cillero
authors.forename: D
authors.initials: D
authors.lastname: Lorenzo
authors.forename: F
authors.initials: F
authors.lastname: Valdés
mesh_terms: D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006323:Heart Arrest; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome