[Expression of GABA(A) receptor alpha1 subunit mRNA in rat flocculus after unilateral labyrinthectomy].
OBJECTIVE
To elucidate the role of the GABA(A) receptor alpha1 subunit in rat flocculus in the recovery from unilateral labyrinthectomy.


METHODS
We used a real-time quantitative reverse transcription polymerase chain reaction method to investigate the mRNA expression of the GABA(A) receptor a1 subunit in the flocculus of the rat 1 and 7 day following the lesion.


RESULTS
GABA(A) receptor a1 subunit was expressed in the flocculus, but no difference in the expression of GABA(A) receptor a1 subunit mRNA could be detected between the ipsilateral and contralateral flocculus at any time following the lesion.


CONCLUSIONS
Our study shows that there is GABA(A) receptor a1 subunit in the rat flocculus. Our data suggest that the expression change of GABA(A) receptor alpha1 subunit mRNA in the flocculus most probably is not involved in the early stage of the vestibular compensation process.
Yu
Qilin
Q
Department of Otorhinolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
Kong
Weijia
W
D000818:Animals; D002529:Cerebellar Nuclei / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000235:genetics / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism; D014722:Vestibule, Labyrinth / Q000378:metabolism / Q000601:surgery*
C546242:Gabra1 protein, rat; D012333:RNA, Messenger; D011963:Receptors, GABA-A