title: [Influence of recombinant human growth hormone on the prognosis of patients with severe burns a prospective multi-center clinical trial].
abstract: OBJECTIVE
  To investigate the influence of recombinant human growth hormone (rhGH) on the mortality of the patients with severe burns.
  
  
  METHODS
  In a prospective multi-center randomized clinical trial, 207 adult patients with severe burns were enrolled in the study, and they were randomly divided into treatment (T, with subcutaneous injection of rhGH) and placebo control (C, with subcutaneous injection of same amount of isotonic saline) groups. The mortality, incidence of hyperglycemia and sepsis in the two groups were observed.
  
  
  RESULTS
  The mortality rate in T group was 0.89% as compared with 5.26% in the C group (P >0.05). Hyperglycemia (blood glucose level over 10 mmol/L) was present in 36.61% of patients in T group but 18.95% in C group (P <0.01). There was no difference in the incidence of sepsis between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  The application of rhGH in appropriate dosage in adult patients with severe burns could be safe, but blood glucose level should be monitored during the administration.
authors.affiliation: Department of Burns, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, P. R. China.
authors.forename: Guo-xian
authors.initials: GX
authors.lastname: Chen
authors.forename: Chun-mao
authors.initials: CM
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose; D002056:Burns / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D019382:Human Growth Hormone