Random genetic drift and gamete frequency.
An analytic expression of conditional expectation of transient gamete frequency, given that one of the two loci remains polymorphic, is obtained in terms of the diffusion process by calculating the moments of the distribution. Using this expression, a model where linkage disequilibrium is introduced by a single mutation is considered. The conditional expectation of the gamete frequency given that the locus with the mutant allele remains polymorphic is presented. The behavior is significantly different from the monotonic decrease observed in the deterministic model without random genetic drift.
Mano
Shuhei
S
Institute of Natural Sciences, Nagoya City University, Nagoya 467-8501, Japan. mano@nsc.nagoya-cu.ac.jp
D003198:Computer Simulation; D040961:Genetic Drift; D005828:Genetics, Population; D005854:Germ Cells; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D011110:Polymorphism, Genetic