title: Synthesis of magnetic nanoparticles and their application to bioassays.
abstract: Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
authors.affiliation: Department of Applied Chemistry, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan. osakatet@waseda.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Osaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Takuya
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Arakaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Niwa
authors.forename: Hironori
authors.initials: H
authors.lastname: Iida
mesh_terms: D001710:Biotin / Q000032:analysis; D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008280:Magnetics; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry; D012680:Sensitivity and Specificity; D019809:Streptavidin / Q000032:analysis; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; D008823:Micelles; D017646:Organosilicon Compounds; C000499:ferric oxide; D001710:Biotin; D019809:Streptavidin