Application of RCM reaction in the construction of ABC ring of micrandilactone A.
[reaction: see text] The functionalized ABC ring system of micrandilactone A was successfully constructed in 14 steps. The key reactions in this synthesis are the intermolecular Diels-Alder reaction (IMDA) and the eneyne ring-closing metathesis (RCM) reaction.
Zhang
Yan-Dong
YD
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Shenzhen Graduate School, Peking University, Beijing.
Tang
Ye-Feng
YF
Luo
Tuo-Ping
TP
Shen
Juan
J
Chen
Ji-Hua
JH
Yang
Zhen
Z