title: Lateral compartment osteoarthritis of the knee after meniscectomy treated by the transplantation of tissue-engineered cartilage and osteochondral plug.
abstract: Management of osteoarthritis of the knee after meniscectomy has been challenging, especially for young patients, because articular cartilage has very poor healing capacity because of its lack of vessels, nerve supply, and isolation from systemic regulation. Osteoarthritic lesions often involve both femoral and tibial cartilage, requiring treatments for both lesions. We report the case of a 14-year-old girl with lateral compartment osteoarthritis of the knee after a total meniscectomy of the discoid meniscus, who was successfully treated by the transplantation of both tissue-engineered cartilage made ex vivo for a femoral lesion and an autologous osteochondral plug for a tibial lesion. We treated both femoral and tibial cartilage defects simultaneously with this procedure. We confirmed cartilaginous regeneration in both femoral and tibial lesions at second-look arthroscopy. This procedure is one option to prevent further development of osteoarthritis in young patients.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. nadachi@hiroshima-u.ac.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Adachi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
authors.forename: Masataka
authors.initials: M
authors.lastname: Deie
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ito
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Izuta
mesh_terms: D000293:Adolescent; D002358:Cartilage, Articular / Q000502:physiology / Q000637:transplantation*; D005260:Female; D005269:Femur / Q000601:surgery; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008592:Menisci, Tibial / Q000601:surgery*; D020370:Osteoarthritis, Knee / Q000209:etiology*; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods; D014182:Transplantation, Autologous