The receptor concept: pharmacology's big idea.
Chemical signalling is the main mechanism by which biological function is controlled at all levels, from the single cell to the whole organism. Chemical recognition is the function of receptors, which, in addition to recognising endogenous chemical signals, are also the target of many important experimental and therapeutic drugs. Receptors, therefore, lie at the heart of pharmacology. This article describes the way in which the receptor concept originated early in the 20th century, and evolved through a highly innovative stage of quantitative theory based on chemical kinetics, to the point where receptors were first isolated and later cloned, until we now have a virtually complete catalogue of all the receptors present in the genome. Studies on signal transduction are revealing great complexity in the events linking ligand binding to the physiological or therapeutic response. Though some simple quantitative rules of 'receptor theory' are still useful, the current emphasis is on unravelling the pathways that link receptors to responses, and it will be some time before we know enough about them to embark on the next phase of 'receptor theory'.
Rang
H P
HP
Humphrey.rang@btopenworld.com
D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008024:Ligands; D010600:Pharmacology / Q000266:history*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000266:history* / Q000502:physiology; D015398:Signal Transduction
D008024:Ligands; D011956:Receptors, Cell Surface