title: Angiographic and clinical results in 316 coil-treated basilar artery bifurcation aneurysms.
abstract: OBJECTIVE
  The aim of this study was to analyze the effect of the endovascular treatment of basilar artery (BA) bifurcation aneurysms and to compare the results with those published by other neuroendovascular teams.
  
  
  METHODS
  The authors performed a retrospective analysis of 316 aneurysms of the BA bifurcation that had been treated using endovascular coil occlusion between November 6, 1992, and February 12, 2005. After the initial embolization procedure, a 90 to 100% occlusion rate was achieved in 86% of the aneurysms. No complication was evident in 80% of the lesions, although periprocedural aneurysm rupture (3.2%) and thromboembolic events (12.3%) were the most frequent complications. Clinical outcome according to the Glasgow Outcome Scale (GOS) was a score of 5 or 4 in 77%, 3 in 11%, 2 in 5%, and 1 in 7% of patients. Initial follow-up angiography studies were obtained in 56% of patients at a mean of 19 months posttreatment and demonstrated a 90 to 100% occlusion rate in 70%. No recurrence was seen on 65% of the aneurysms. Coil compaction was evident on 24% of the follow-up angiograms. A second treatment was performed on 48 aneurysms (15%) a mean of 27 months after the first therapeutic session and resulted in 90 to 100% occlusion in 83% of the lesions. Complications were encountered in 19% of the aneurysms. Rupture did not occur during any of the procedures. Clinical outcome was rated as GOS Score 5 or 4 in 83% of the patients and Grade 3 in 17%. During a cumulative clinical follow up of 821 years in 237 patients, 182 patients (81%) were independent (GOS Score 5 or 4), 33 (14%) were dependent (GOS Score 3), eight (3%) were in a vegetative state, and two (1%) had died. Clinical outcome was significantly worse after previous aneurysm rupture and following procedural complications.
  
  
  CONCLUSIONS
  These results are within the range of published data for coil treatment of BA tip aneurysms and confirm both the safety and efficacy of this endovascular treatment method.
authors.affiliation: Klinik für Radiologie und Neuroradiologie, Alfried Krupp Krankenhaus, Essen, Germany. HHHenkes@aol.com
authors.forename: Hans
authors.initials: H
authors.lastname: Henkes
authors.forename: Sebastian
authors.initials: S
authors.lastname: Fischer
authors.forename: Wagner
authors.initials: W
authors.lastname: Mariushi
authors.forename: Werner
authors.initials: W
authors.lastname: Weber
authors.forename: Thomas
authors.initials: T
authors.lastname: Liebig
authors.forename: Elina
authors.initials: E
authors.lastname: Miloslavski
authors.forename: Stefan
authors.initials: S
authors.lastname: Brew
authors.forename: Dietmar
authors.initials: D
authors.lastname: Kühne
mesh_terms: D017542:Aneurysm, Ruptured / Q000209:etiology; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation / Q000401:mortality; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D018458:Persistent Vegetative State / Q000209:etiology; D012008:Recurrence; D019233:Retreatment; D012189:Retrospective Studies; D013923:Thromboembolism / Q000209:etiology; D016896:Treatment Outcome