[Expression of BAG-1 and p53 in laryngeal squamous cell carcinoma and their clinical significance].
OBJECTIVE
To study the expression of BAG-1 and p53 in laryngeal squamous cell carcinoma (LSCC), and the relation between BAG-1 and p53.


METHODS
BAG-1 and p53 protein were examined by using the method of immunohistochemical SP staining method in 40 cases of LSCC, 27 cases of pap- a-cancerous tissues and 20 cases of polyp specimens from vocal cord tissues.


RESULTS
The positive expression of BAG-1 in. LSCC was significantly higher than that in para-cancerous tissues and polyp specimens from vocal cord tissues (P < 0.05). The positive expressions of BAG-1 were related to the prognosis (P < 0.05), and BAG-1 in LSCC with nucleus staining had worse prognosis than that with cytoplasm staining (P < 0.05). The positive expression of p53 in LSCC was significantly higher than that in para-cancerous tissues and polyp specimens from vocal cord tissues (P < 0.05). The positive expressions of p53 were related to the differentiation grades, cervical lymph node metastasis and prognosis (P < 0.05). There was no significance correlation between BAG-1 and p53 expression (P > 0.05).


CONCLUSIONS
Over expression of BAG-1 and p53 play an important role in the process of development of LSCC; BAG-1 may be a biological predictor of early period in LSCC, especially nuclear BAG-1 localization may be a prediction of unfavorable outcome. Expression of p53 is related with cervical lymph node metastasis, and that is a prognostic target.
Wu
Shuhui
S
Department of Otolaryngology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. wsh-1227@163.com
Jiang
Xiaoqing
X
Zhou
Xuhong
X
Yin
Shucheng
S
D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D008207:Lymphatic Metastasis; D011379:Prognosis; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
C091732:BCL2-associated athanogene 1 protein; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53