title: Analysis of a hybrid spectral strain estimation technique in elastography.
abstract: Conventional spectral elastographic techniques estimate strain using cross-correlation methods. Despite promising results, decorrelation effects compromise the accuracy of these techniques and, subsequently, the tissue strain estimates. Since tissue compression in the time-domain corresponds to upscaling in the frequency-domain, decorrelation effects become more pronounced as tissue strains increase and are a fundamental concern in spectral cross-correlation elastography. In this paper, a two-stage hybrid spectral elastographic technique is introduced. For the first stage, an approximated spectral scaling factor (i.e. initial strain estimate) is employed to compensate for bandwidth broadening (due to tissue compression) between pre- and post-compression power spectra pairs. The second stage then estimates any residual strain information using spectral cross-correlation methods due to improper scaling factor selection in the first stage. This novel hybrid spectral elastographic technique was compared to both conventional spectral and adaptive temporal elastographic methods in simulation and experimentation. In addition to demonstrating enhancement in performance over the conventional spectral elastographic technique, the hybrid spectral-based method introduced in this paper is shown to outperform the adaptive temporal-based elastographic approach.
authors.affiliation: Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hoyt
authors.forename: Flemming
authors.initials: F
authors.lastname: Forsberg
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ophir
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004548:Elasticity; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D013314:Stress, Mechanical