title: Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis.
abstract: Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2',3'-dihydroxy-4',6'-dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. Of these constituents, compounds 2 (IC50: 3.89 +/- 0.39 microM) and 3 (IC50: 9.77 +/- 0.26 microM) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 (IC50: 28.4 +/- 2.62 microM) exhibited moderate inhibitory activity.
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Caugiay, Hanoi.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Hoang Thanh
authors.initials: HT
authors.lastname: Huong
authors.forename: Jung Joon
authors.initials: JJ
authors.lastname: Lee
authors.forename: Im Seon
authors.initials: IS
authors.lastname: Lee
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D029061:Annonaceae; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001593:Benzyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D000432:Methanol / Q000737:chemistry; D050778:NFATC Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C507559:2',3'-dihydroxy-4',6'-dimethoxydihydrochalcone; C507556:2-methoxybenzyl benzoate; D001565:Benzoates; D001593:Benzyl Compounds; D047188:Chalcones; D044950:Flavanones; D047309:Flavones; D044948:Flavonols; D050778:NFATC Transcription Factors; D010636:Phenols; D010936:Plant Extracts; C507557:negletein; C099069:astilbin; C012526:quercitrin; D011794:Quercetin; C028610:flavanone; D000432:Methanol