Effect of a single early-gestational alcohol consumption on the insulin binding by immune cells of adult rats.
Rat dams were exposed to 15% ethanol containing water ad libitum for 24 h at the 3rd day of gestation. Adult progenies' immune cells (peritoneal, blood and thymic lymphocytes, monocyte-macrophage-granulocyte group and mast cells) were studied by flow cytometry for binding of FITC-labelled insulin (compared to the appropriate cells of untreated animals). All of the cell types studied bound significantly less insulin, except mast cells. The results call attention to the life-long effect of occasional alcohol consumption in early pregnancy manifested in the immune system.
Pállinger
E
E
Immunogenomic Research Group, Hungarian Academy of Sciences, 1445 Budapest, Hungary.
Csaba
G
G
D000428:Alcohol Drinking; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D005434:Flow Cytometry; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives; D006098:Granulocytes / Q000378:metabolism; D007328:Insulin / Q000031:analogs & derivatives / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008407:Mast Cells / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; C031573:insulin, fluorescein-isothiocyanated-; D000431:Ethanol; D016650:Fluorescein-5-isothiocyanate