Lycoperine A, A novel C27N3-type pentacyclic alkaloid from Lycopodium hamiltonii, inhibiting acetylcholinesterase.
[structure: see text] A novel C(27)N(3)-type pentacyclic Lycopodium alkaloid, lycoperine A (1) consisting of two octahydroquinoline rings and a piperidine ring, was isolated from the club moss Lycopodium hamiltonii. The structure and relative stereochemistry were elucidated on the basis of 2D NMR data and chemical transformation. Lycoperine A (1) exhibited an inhibitory activity against acetylcholinesterase.
Hirasawa
Yusuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.
Kobayashi
Jun'ichi
J
Morita
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032502:Lycopodium / Q000737:chemistry*; D008958:Models, Molecular; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011804:Quinolines; C507691:lycoperine A