Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling.
A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTc-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.
Le Gal
Julien
J
Laboratoire de Chimie Inorganique, EA 807, Université Paul Sabatier, Bat. IIR1, 118, route de Narbonne, 31062 Toulouse, France.
Michaud
Sandra
S
Gressier
Marie
M
Coulais
Yvon
Y
Benoist
Eric
E
D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D008024:Ligands; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000737:chemistry; D013667:Technetium / Q000737:chemistry*
D002614:Chelating Agents; D008024:Ligands; D012211:Rhenium; D013667:Technetium