The Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context.
MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-protein interaction database (MPPI) and a database of mammalian protein complexes is interconnected with MfunGD. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme which is widely used for the analysis of protein networks. The dataset is also supplemented with information about the literature that was used in the annotation process as well as links to the SIMAP Fasta database, the Pedant protein analysis system and cross-references to external resources. Proteins that so far were not manually inspected are annotated automatically by a graphical probabilistic model and/or superparamagnetic clustering. The database is continuously expanding to include the rapidly growing amount of functional information about gene products from mouse. MfunGD is implemented in GenRE, a J2EE-based component-oriented multi-tier architecture following the separation of concern principle.
Ruepp
Andreas
A
Institute for Bioinformatics (MIPS), GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany. andreas.ruepp@gsf.de
Doudieu
Octave Noubibou
ON
van den Oever
Jos
J
Brauner
Barbara
B
Dunger-Kaltenbach
Irmtraud
I
Fobo
Gisela
G
Frishman
Goar
G
Montrone
Corinna
C
Skornia
Christine
C
Wanka
Steffi
S
Rattei
Thomas
T
Pagel
Philipp
P
Riley
Louise
L
Frishman
Dmitrij
D
Surmeli
Dimitrij
D
Tetko
Igor V
IV
Oesterheld
Matthias
M
Stümpflen
Volker
V
Mewes
H Werner
HW
D000818:Animals; D030541:Databases, Genetic; D023281:Genomics; D020407:Internet; D051379:Mice / Q000235:genetics*; D046912:Multiprotein Complexes / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D040901:Proteomics; D012984:Software; D014584:User-Computer Interface
D046912:Multiprotein Complexes