[Lipid peroxidation product as prognostic factors in acute necrotizing pancreatitis].
The aim of the study is the assessment of the role of oxygen free radicals (OFRs) in the pathology of acute pancreatitis (AP).


METHODS
It has been accomplished based on the analysis of lipid peroxidation products' and hydrogen peroxide blood concentration in 60 patients with AP. Spectrometric and spectrofluorometric methods were used. Patients were divided into 2 groups. Group 1 consisted of 42 patients, who survived the 30 day observation period. Group 2 included patients, with a systematic deterioration resulting in death. All patients were subjected to surgery between the 15th and 30th day of observation because of septic syndrome signs. On 1st, 5th, 10th, and 15th day of treatment we measured concentrations of lipid peroxidation products such as: conjugated dienes (CD), malonyl dialdehyde (MDA), Schiff's bases, lipid peroxides (LOOH), and hydrogen peroxide.


RESULTS
We observed high levels of CDs and MDA throughout the entire observation period as well as increase in lipid and hydrogen peroxide serum concentrations in patients with poor prognoses. Shiff's bases serum concentrations presented a non-characteristic pattern of changes.


CONCLUSIONS
Lipid peroxidation products' metabolism path observed in our study suggests a substantial role of oxygen free radicals in acute pancreatitis pathology. Authors claim, that the assessment of lipid peroxidation product serum concentrations may be a useful marker for prognosing in most severe forms of acute pancreatitis.
Modzelewski
Bogdan
B
Klinika Chirurgii Ogólnej i Gastroenterologicznej Uniwersytetu Medycznego, Lodzi. Bogdanm@ventura.pl
Janiak
Adam
A
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000378:metabolism* / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000097:blood*; D012720:Severity of Illness Index
D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D006861:Hydrogen Peroxide