Experimental posterior perforating ocular injury in rabbit eyes: effects of radiotherapy with or without intravitreal cyclosporin on vitreous proliferation.
Double perforating ocular injuries were made in 30 rabbits and the effects of radiotherapy (RT) alone or in combination with cyclosporin (CS) on vitreous proliferation investigated. Thirteen rabbits in group 1 received RT alone (600 cGy), and 13 rabbits in group 2 received RT combined with 100 microg of intravitreal CS. No treatment was given to 4 rabbits in the control group (group 3). All animals were ophthalmologically examined on the 1st, 3rd, 7th, 14th and 28th days following the injury and the clinical findings scored; they were sacrificed on the 28th day, and histopathological scoring was made. The median histopathological score of the RT group (4.0; range: 0-8) was significantly higher than that of the CS + RT group (1.0; range: 0-5; p = 0.018). We conclude that intravitreal CS may be used as an adjunctive agent to RT to inhibit intraocular proliferation following penetrating ocular injury in rabbits.
Karakücük
Sarper
S
Department of Ophthalmology, Erciyes University Faculty of Medicine, Kayseri, Turkey. sarper@erciyes.edu.tr
Soyuer
Serdar
S
Oner
Ayse Oztürk
AO
Soyuer
Isin
I
Yaray
Kadir
K
Mirza
Ertugrul
E
Baskol
Gülden
G
Akin
Aynur
A
D000818:Animals; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D015807:Eye Injuries, Penetrating / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007267:Injections; D011817:Rabbits; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D018630:Vitreoretinopathy, Proliferative / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D014822:Vitreous Body
D007166:Immunosuppressive Agents; D016572:Cyclosporine