[Influence of lidocaine on systemic inflammation in perioperative patients undergoing cardiopulmonary bypass].
OBJECTIVE
To investigate the influence of lidocaine on systemic inflammation in the perioperative ventricular septal defect (VSD).


METHODS
Twenty patients, scheduled for ventricular septal defect were randomly divided into 2 groups: lidocaine and control groups. Before rebeat lidocaine 1 mg/kg was given. The venous blood samples were obtained from the central venous at the following points: after induction of anesthesia and before cardiopulmonary bypass(CPB,T1),1 h after CPB(T2),2 h after CPB(T3), and 4 h after CPB(T4). IL-6 and IL-8 were determined by radio-immunoassay.


RESULTS
Compared with those at T1, the levels of white blood cells,polymorphonuclear neutrophils,IL-6 and IL-8 increased significantly from T2 to T4 in both groups. IL-6 and IL-8 levels reached the peak at T2. Compared with those in control groups, IL-6 level decreased obviously in lidocaine group from T2 to T4, but IL-8 level remained unchanged significantly.


CONCLUSIONS
Under CPB and VSD repair the systemic inflammation is obvious, reaches the peak 30 min after CPB and persists to 4 h after CPB. Perioperative administration of lidocaine is effective against the inflammation.
Sun
Chuan-bin
CB
Department of Cardiosurgery, Peking University Shenzhen Hospital, Shenzhen 518036, China. sunchuanbin@yahoo.com.cn
Chen
Li-bo
LB
Cheng
Ying
Y
Feang
Gang
G
Zhang
Wei-xing
WX
D000293:Adolescent; D002315:Cardiopulmonary Bypass; D002648:Child; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000097:blood / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D019990:Perioperative Care; D011863:Radioimmunoassay; D016896:Treatment Outcome
D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D008012:Lidocaine