title: Ochronotic arthropathy: disappearance of alkaptonuria after liver transplantation for hepatitis B-related cirrhosis.
abstract: The deficiency of homogentisic acid oxidase, an enzyme that is mainly found in hepatocytes, is associated with alkaptonuria and ochronosis. We report a patient with clinical and radiologic findings of ochronotic arthropathy in whom alkaptonuria disappeared and the progressive course of the disease stopped after liver transplantation for hepatitis B-related cirrhosis.
authors.affiliation: Department of Medicine, Section of Gastroenterology and Hepatology, Ege University, School of Medicine, Bornova, Izmir, Turkey. arzukobak@yahoo.com
authors.forename: Arzu Celebi
authors.initials: AC
authors.lastname: Kobak
authors.forename: Gonca
authors.initials: G
authors.lastname: Oder
authors.forename: Senol
authors.initials: S
authors.lastname: Kobak
authors.forename: Mehmet
authors.initials: M
authors.lastname: Argin
authors.forename: Vedat
authors.initials: V
authors.lastname: Inal
mesh_terms: D000474:Alkaptonuria / Q000150:complications* / Q000000981:diagnostic imaging / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000150:complications*; D006713:Homogentisic Acid / Q000652:urine; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008159:Lumbar Vertebrae; D008875:Middle Aged; D009794:Ochronosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000652:urine; D011859:Radiography; D025241:Spondylarthritis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000652:urine
chemical_list: D006713:Homogentisic Acid