Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene.
Sterol Regulatory Element Binding Proteins (SREBP) are transcription factors that regulate lipid synthesis. We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region. We describe here the function of an additional SREBP-responsive element located in the first intron. Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells.
Logette
E
E
INSERM U517, IFR100, Faculté de Médecine, 7 bd Jeanne of Arc, 21000 Dijon, France.
Solary
E
E
Corcos
L
L
D001665:Binding Sites; D053143:Caspase 2; D020169:Caspases / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D006801:Humans; D007438:Introns; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism*; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
C497390:SREBF2 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D051782:Sterol Regulatory Element Binding Protein 2; D004247:DNA; D053143:Caspase 2; D020169:Caspases