Role of transcription factors in commitment and differentiation of early B lymphoid cells.
B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted into antibody-producing plasma cells. B cell differentiation involves multiple steps, including cell specification, commitment to the B cell lineage, immunoglobulin rearrangements, maturation of B cells and terminal differentiation into plasma cells. Each of these steps is controlled by signaling pathways and transcription factors that act in synergy, feedback-loops or cross-antagonism to generate complex regulatory networks that allow for plasticity and stability of B cell differentiation.
Roessler
Stephanie
S
Max-Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, Stubeweg 51, 79108 Freiburg, Germany.
Grosschedl
Rudolf
R
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D014157:Transcription Factors / Q000502:physiology*
D014157:Transcription Factors