title: High-rate pulmonary involvement in autoimmune pancreatitis.
abstract: Autoimmune pancreatitis (AIP) has extrapancreatic complications such as Sjögren's syndrome, retroperitoneal fibrosis and sclerosing cholangitis. We studied 30 patients with AIP. Of these, we identified pulmonary involvement in four patients during follow up. Among them, two patients had respiratory failure. They showed good response to steroid therapy, but a higher dose of prednisolone was necessary to maintain remission than that required in biliary involvement. Elevation of immunoglobulin G(4) and Krebs von den Lungen-6 levels were characteristic of pulmonary involvement. They may be useful for early detection of pulmonary complication.
authors.affiliation: Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan. khirano-tky@umin.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Hirano
authors.forename: T
authors.initials: T
authors.lastname: Kawabe
authors.forename: Y
authors.initials: Y
authors.lastname: Komatsu
authors.forename: S
authors.initials: S
authors.lastname: Matsubara
authors.forename: O
authors.initials: O
authors.lastname: Togawa
authors.forename: T
authors.initials: T
authors.lastname: Arizumi
authors.forename: N
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.forename: N
authors.initials: N
authors.lastname: Sasahira
authors.forename: T
authors.initials: T
authors.lastname: Tsujino
authors.forename: N
authors.initials: N
authors.lastname: Toda
authors.forename: H
authors.initials: H
authors.lastname: Isayama
authors.forename: M
authors.initials: M
authors.lastname: Tada
authors.forename: M
authors.initials: M
authors.lastname: Omata
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D010195:Pancreatitis / Q000150:complications* / Q000276:immunology; D011239:Prednisolone / Q000008:administration & dosage; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone