title: Morphometric and microscopic evaluation of the effect of solution of acetazolamide as an intracanal therapeutic agent in late reimplanted rat teeth.
abstract: The use of substances that inhibit root resorption may be an alternative for cases of unsuccessful reimplants. Hence, the purpose of this study was to test a solution of acetazolamide, a resorption inhibitor, as an intracanal therapeutic agent for late reimplanted teeth. Thirty rat maxillary right central incisors were avulsed and kept dry for 30 min. The teeth were instrumented, and the root surfaces treated with 1% hypochlorite solution followed by application of 2% sodium fluoride. Thereafter, the teeth were divided into two groups according to the intracanal dressing: Group I, solution of acetazolamide and Group II, calcium hydroxide paste. Teeth were then reimplanted in their respective sockets. The animals were killed at 15, 30, and 60 days after reimplantation and the samples processed for morphometric and microscopic analysis. The results showed that calcium hydroxide paste limited root resorption, even though not avoiding it. In contrast, no root resorption was observed after 60 days in the acetazolamide group, confirming the efficacy of the substance in inhibiting root resorption.
authors.affiliation: Endodontics of Dentistry School of Bauru, University of São Paulo, Bauru, São Paulo, Brazil. grazielagm@uol.com.br
authors.forename: Graziela Garrido
authors.initials: GG
authors.lastname: Mori
authors.forename: Roberto Brandão
authors.initials: RB
authors.lastname: Garcia
authors.forename: Ivaldo
authors.initials: I
authors.lastname: Gomes de Moraes
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000818:Animals; D002126:Calcium Hydroxide / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D003890:Desiccation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D012388:Root Canal Irrigants / Q000627:therapeutic use*; D012391:Root Resorption / Q000517:prevention & control*; D018709:Statistics, Nonparametric; D014090:Tooth Replantation
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D000086:Acetazolamide; D002126:Calcium Hydroxide