[Chemical destruction of the prostate by Prostalyser-1 and Prostalyser-2 solutions: an experimental study in dogs].
The aim of the study was elaboration of a new minimally invasive but effective alternative method of BPH treatment. The experiments were carried out on 46 male dogs divided into two equal groups. 10 ml of Prostalyser-1 solution (natrii chloridi 9.5 g, dimethylsulfoxidi 0.5 g, aquae destill. Ad 1000.0 g) was given in a single injection into the prostates of the first group of animals. The same volume of Prostalyser-2 solution (spiritus ethilicus 96% - 76.5 g, DMSO 0.5 g, aq.destill ad 100.0 g)--into the prostates of the other group, respectively. The temperature of the solutions was +80 degrees C. Within the first 2 months, essential disorders were observed in the cellular Na-pump, membrane permeability system, there were lobular and diffusive necroses in prostatic alveolar epithelium and a decrease of the prostate weight by 68-66%. This condition of the prostate persisted for 4-6 months. Prostalyser-1 and Prostalyser-2 solutions can be recommended as very prospective substances for chemical destruction of the prostate in case of BPH.
Shioshvili
T I
TI
Chokhonelidze
G Z
GZ
Shulaia
Ts A
TsA
Kazaishvili
E D
ED
Gogoladze
T V
TV
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use; D007267:Injections; D008297:Male; D019999:Pharmaceutical Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D019999:Pharmaceutical Solutions; D000431:Ethanol; D012965:Sodium Chloride; D012964:Sodium; D011188:Potassium; D004121:Dimethyl Sulfoxide