Listeria monocytogenes as a probe of immune function.
For almost half a century, the mouse model of Listeria monocytogenes infection has been used to analyse both innate and adaptive components of immunity and to discover key immune genes. Vast accumulated knowledge about the disease in mice provides a unique framework for identifying and characterising immune molecules using a variety of experimental approaches. To illustrate the range of questions that can be addressed using modern genetics and genomics tools, the authors provide an overview of the analysis of components of immune signalling networks using the mouse model of L. monocytogenes infection.
Garifulin
Oleg
O
Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA.
Boyartchuk
Victor
V
D000818:Animals; D003182:Complement C5 / Q000235:genetics; D014644:Genetic Variation; D005823:Genetics; D016678:Genome; D023281:Genomics; D006801:Humans; D007107:Immune System / Q000473:pathology; D007110:Immunity, Active; D007113:Immunity, Innate; D008089:Listeria monocytogenes / Q000378:metabolism*; D008088:Listeriosis / Q000235:genetics; D051379:Mice; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D019076:Transgenes
D003182:Complement C5