Comparison of prednisolone with piroxicam in complex regional pain syndrome following stroke: a randomized controlled trial.
BACKGROUND
Complex regional pain syndrome (CRPS) following stroke aggravates morbidity. CRPS is categorized as CRPSI when no clear nerve injury is defined, and CRPSII when associated with clear nerve injury.


OBJECTIVE
To compare the effect of prednisolone with that of piroxicam in patients with CRPSI following stroke.


METHODS
Randomized controlled trial.


METHODS
Patients with CRPSI fulfilling the inclusion criteria (n = 60) underwent a detailed neurological examination, cranial CT scan, radiograph of chest and shoulder joint, blood counts and serum chemistry. Severity of stroke was assessed by the Canadian Neurological Scale (CNS), CRPS by scoring sensory, autonomic and motor symptoms, and activity of daily living by Barthel index (BI) score. Patients were randomly assigned prednisolone 40 mg or piroxicam 20 mg daily, and outcome was assessed at 1 month on the basis of CRPS and BI score.


RESULTS
Mean patient age was 56 years and 20 were female. Baseline clinical and radiological parameters were comparable between the two groups. In the prednisolone group, 83.3% patients showed significant improvement, compared to 16.7% in the piroxicam group. The mean change in CRPS score in prednisolone group was 6.47 (95%CI 4.37-7.36), whereas in piroxicam group it was only 0.47. The mean change in BI score was 7.9 (95%CI 0.82-5.98) in the prednisolone group, and 4.5 in the piroxicam group.


CONCLUSIONS
In this patient group, prednisolone resulted in significant improvement in the symptoms and signs of CRPSI following stroke, compared to piroxicam. Both drugs produced an improvement in the BI score.
Kalita
J
J
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow 226014, India. jkalita@sgpgi.ac.in
Vajpayee
A
A
Misra
U K
UK
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D020918:Complex Regional Pain Syndromes / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D020521:Stroke / Q000150:complications*
D000893:Anti-Inflammatory Agents; D010894:Piroxicam; D011239:Prednisolone