title: Autoimmune hemolytic anemia in an elderly patient with primary Sjögren's syndrome.
abstract: Primary Sjögren's syndrome is an autoimmune disease characterized by lymphocytic infiltration of the salivary glands and lacrimal glands. The histological features of chronic inflammation in primary Sjögren's syndrome may be associated with B cell hyper-reactivity. This syndrome also has various manifestations associated with other exocrine glands and nonglandular tissues. The hematological abnormalities usually seen in Sjögren's syndrome are lymphopenia, leucopenia, and thrombocytopenia. Although the direct Coomb's test is often positive, the occurrence of autoimmune hemolytic anemia (AIHA) is rare. Here, we report an elderly patient with primary Sjögren's syndrome who developed AIHA during the clinical course.
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kikawada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Watanabe
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kimura
authors.forename: Haruo
authors.initials: H
authors.lastname: Hanyu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Serizawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iwamoto
mesh_terms: D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D001706:Biopsy; D003298:Coombs Test; D003937:Diagnosis, Differential; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology