title: Experimental assessment of the pathogenicity of H5N1 influenza A viruses isolated in Japan.
abstract: We examined the pathogenicity for chickens of two H5N1 avian influenza viruses isolated in Japan, A/chicken/ Yamaguchi/7/2004 (Ck/Yamaguchi/7/04) isolated from outbreaks in commercial layer chickens, and A/duck/Yokohama/aq10/ 2003 (Dk/Yokohama/aq10/03) isolated from duck meat imported from China. All chickens inoculated intranasally with either strain died, and the viruses were reisolated from all organs examined. However, both the mean time of onset of clinical signs and the mean death time of Ck/Yamaguchi/7/04 were shorter than those of Dk/Yokohama/aq10/03.
authors.affiliation: Department of Infectious Diseases, National Institute of Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Masaji
authors.initials: M
authors.lastname: Mase
authors.forename: Tadao
authors.initials: T
authors.lastname: Imada
authors.forename: Kikuyasu
authors.initials: K
authors.lastname: Nakamura
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Tanimura
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Imai
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yamaguchi
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D002642:Chick Embryo; D002645:Chickens / Q000821:virology*; D002681:China; D004372:Ducks / Q000821:virology; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000209:etiology / Q000821:virology*; D007564:Japan; D013045:Species Specificity; D013997:Time Factors; D014774:Virulence