title: Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans.
abstract: Infarct size (IS) increases with vascular occlusion time, area at risk for infarction, lack of collateral supply, absence of preconditioning, and myocardial demand for O2 supply. ECG S-T segment elevation is used as a measure of severity of ischemia and a surrogate for IS. This study in 50 patients with coronary artery disease undergoing a first 120-s balloon occlusion of a stenosis sought to determine whether S-T segment elevation, corrected for the above-mentioned variables, in the left coronary artery (LCA group, n = 36) is different from that in the right coronary artery (RCA group, n = 14) territory. After consideration of all known determinants of IS, particularly mass at risk and collateral supply, the LCA territory is more sensitive than the RCA region to a 2-min period of myocardial ischemia.
authors.affiliation: Department of Cardiology, University Hospital, Bern, Switzerland.
authors.forename: Stefano F
authors.initials: SF
authors.lastname: De Marchi
authors.forename: Pascal
authors.initials: P
authors.lastname: Meier
authors.forename: Philipp
authors.initials: P
authors.lastname: Oswald
authors.forename: Christian
authors.initials: C
authors.lastname: Seiler
mesh_terms: D003324:Coronary Artery Disease / Q000145:classification / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D019194:Ischemic Preconditioning / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index