title: Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis.
abstract: Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-gamma secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.
authors.affiliation: Section of Infectious Disease, Department of Internal Medicine, Korea University Medical College, Korea University Guro Hospital, 97 Guro Dong-Gil, Guro Gu, Seoul 152-703, South Korea. heejinmd@medimail.co.kr
authors.forename: Hee-Jin
authors.initials: HJ
authors.lastname: Cheong
authors.forename: Joon-Young
authors.initials: JY
authors.lastname: Song
authors.forename: Jeong-Won
authors.initials: JW
authors.lastname: Park
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Yeon
authors.forename: Kwan-Soo
authors.initials: KS
authors.lastname: Byun
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Lee
authors.forename: Hyun-Il
authors.initials: HI
authors.lastname: Cho
authors.forename: Tai-Gyu
authors.initials: TG
authors.lastname: Kim
authors.forename: Woo-Joo
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis; D008103:Liver Cirrhosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D007371:Interferon-gamma