title: Elevated postmortem ethanol concentrations in an insulin-dependent diabetic.
abstract: A 54-year-old woman (165 cm, 37 kg) was found dead in her home during a welfare check after not having been seen for at least three days. The body showed clear evidence of decomposition. Her head was in what appeared to be a pool of blood. The residence was clean, neat, and showed no evidence of violence. Insulin was found in the refrigerator, and syringes were in the kitchen cabinet. In agreement with these physical findings, her clinical history indicated that she suffered insulin-dependent diabetes mellitus. Autolytic changes were noticed at autopsy, and no obvious cause of death was demonstrated. The autopsy heart blood sample screened negative for cocaine and/or metabolite (benzoylecgonine), phenethylamines, opiates, and barbiturates by radioimmunoassay. The alcohol concentration was 0.51 g/dL in the blood, 0.04 g/dL in the brain, 0.08 g/dL in the liver, and 0.05 g/dL in the urine, and acetone levels were 42 mg/dL, 53 mg/dL, 14 mg/dL, and 19 mg/dL, respectively. Isopropanol was also present in all samples analyzed. The cause of death was ruled as metabolic acidosis due to diabetes mellitus. Possible bacterial postmortem production of ethanol is considered as an explanation for the increased concentration of ethanol found in the postmortem heart blood.
authors.affiliation: Forensic Science Services, Orange County Sheriff-Coroner Department, 320 North Flower, Santa Ana, California 92703, USA.
authors.forename: Ines B
authors.initials: IB
authors.lastname: Collison
mesh_terms: D002423:Cause of Death; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D016883:Diabetic Ketoacidosis / Q000097:blood* / Q000209:etiology; D000431:Ethanol / Q000097:blood*; D017809:Fatal Outcome; D005260:Female; D005554:Forensic Medicine; D006801:Humans; D008875:Middle Aged; D011180:Postmortem Changes
chemical_list: D000431:Ethanol