Drug release from core-shell type nanoparticles of poly(DL-lactide-co-glycolide)-grafted dextran.
This study prepared core-shell type nanoparticles of a poly(DL-lactide-co-glycolide) (PLGA) grafted-dextran. The synthesis of the PLGA-dextran conjugate was confirmed by Fourier transform-infrared (FT-IR) spectroscopy. The PLGA grafted-dextran was able to form nanoparticles in water by self-assembly and their particle size was 245.3 +/- 95.1 nm. From fluorescence probe study using pyrene as a hydrophobic probe, critical association concentration (CAC) values were determined from the fluorescence excitation spectra and were found to be 0.006 g l(-1). Morphological observations using a scanning electron microscope (SEM) showed that the polymeric nanoparticles of the PLGA-dextran conjugate have uniformly spherical shapes. Their size and morphology provide them with acceptable properties for use as a drug-targeting carriers. Drug release from core-shell type nanoparticles was faster in the presence of dextranase, indicating that core-shell type nanoparticles of PLGA grafted-dextran can be used as an oral drug carriers.
Jung
Sun-Woong
SW
College of Pharmacy, Chosun University, Gwangju, South Korea.
Jeong
Young-Il
YI
Kim
Young-Hoon
YH
Choi
Ki-Choon
KC
Kim
Sung-Ho
SH
D000284:Administration, Oral; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D003910:Dextranase; D003911:Dextrans / Q000008:administration & dosage; D004121:Dimethyl Sulfoxide; D004339:Drug Compounding / Q000379:methods; D005453:Fluorescence; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning / Q000379:methods; D049329:Nanostructures; D010316:Particle Size; D010952:Plasma Substitutes / Q000008:administration & dosage; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D012995:Solubility; D012997:Solvents; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013499:Surface Properties
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D003911:Dextrans; D010952:Plasma Substitutes; D011108:Polymers; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003910:Dextranase; D004121:Dimethyl Sulfoxide