Epstein-Barr virus-associated bronchial leiomyoma in a boy with cellular immunodeficiency.
Bronchial leiomyoma is a rare disease in children. Recently, the association of leiomyoma and HIV infection was reported. We describe a boy with a cellular immunodeficiency, who had endobronchial leiomyoma. The tumor cells were positive for Epstein-Barr virus-encoded RNA-1 (EBER-1) and Epstein-Barr virus-determined nuclear antigen-2, suggesting a role of Epstein-Barr virus in the pathogenesis of leiomyoma.
Hatano
Miho
M
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takada
Hidetoshi
H
Nomura
Akihiko
A
Ohga
Shouichi
S
Ohshima
Koichi
K
Saeki
Isamu
I
Tajiri
Tatsuro
T
Taguchi
Tomoaki
T
Suita
Sachiyo
S
Hara
Toshiro
T
D001984:Bronchial Neoplasms / Q000150:complications / Q000601:surgery / Q000821:virology*; D002648:Child; D003175:Complement C2 / Q000172:deficiency; D003186:Complement C9 / Q000172:deficiency; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007889:Leiomyoma / Q000150:complications / Q000601:surgery / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000032:analysis*; D014412:Tumor Virus Infections / Q000235:genetics
D003175:Complement C2; D003186:Complement C9; D019309:Epstein-Barr Virus Nuclear Antigens; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral