Treatment with olanzapine increases cell proliferation in the subventricular zone and prefrontal cortex.
The present study examines the effect of chronic treatment with two atypical neuroleptics, commonly used to treat schizophrenia. Adult rats were given either risperidone or olanzapine in their drinking water for 21 days. Memory was assessed on the first and last day of treatment using an object discrimination test, and the rate of cell proliferation in the subventricular zone (SVZ), dentate gyrus (DG) and prefrontal cortex (PFC) was quantified by immuno staining for Ki-67. The results show that both risperidone and olanzapine significantly improved performance in object discrimination after 21 days, and additionally, olanzapine significantly increased cell proliferation in the SVZ and PFC but not the DG.
Green
William
W
Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.
Patil
Parag
P
Marsden
Charles A
CA
Bennett
Geoffery W
GW
Wigmore
Peter M
PM
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000166:cytology* / Q000378:metabolism; D003071:Cognition / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000378:metabolism; D004192:Discrimination, Psychological / Q000187:drug effects; D004334:Drug Administration Schedule; D007158:Immunologic Techniques; D019394:Ki-67 Antigen / Q000378:metabolism; D008568:Memory / Q000187:drug effects; D000077152:Olanzapine; D017397:Prefrontal Cortex / Q000166:cytology* / Q000378:metabolism; D051381:Rats; D018967:Risperidone / Q000494:pharmacology; D013194:Staining and Labeling
D014150:Antipsychotic Agents; D019394:Ki-67 Antigen; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine