Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental and theoretical models.
The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.
Kohl
Peter
P
The Cardiac Mechano-Electric Feedback Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. peter.kohl@physiol.ox.ac.uk
Bollensdorff
Christian
C
Garny
Alan
A
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D004594:Electrophysiology; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006329:Heart Conduction System; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D040542:Mechanotransduction, Cellular; D008564:Membrane Potentials; D008955:Models, Cardiovascular; D010812:Physical Stimulation; D012106:Research / Q000191:economics; D012107:Research Design; D016276:Ventricular Function
D007473:Ion Channels