title: Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home.
abstract: The lifelong IgG replacement therapy for patients with primary immunedeficiencies (PIDD) may be provided by intravenous (IVIG) or by subcutaneous IgG (SCIG) infusions. We investigated the impact of weekly SCIG self-infusions at home on the health-related quality of life, treatment satisfaction, and preferences in patients treated with IVIG at the hospital/doctor's office (Group A) or at home (Group B) before the study started. Forty-four adult North American PIDD patients were included in the study, 28 patients in Group A and 16 in Group B. Patients in Group A reported significantly less limitations with their work/daily activities, a significantly improved vitality, and better general health. Treatment satisfaction was significantly improved in Group A. The preference for the subcutaneous route and for home therapy was respectively 81% and 90% in Group A. In Group B, 69% preferred the subcutaneous route and 92% home therapy.
authors.affiliation: Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden. uwe.nicolay@labmed.ki.se
authors.forename: Uwe
authors.initials: U
authors.lastname: Nicolay
authors.forename: Peter
authors.initials: P
authors.lastname: Kiessling
authors.forename: Melvin
authors.initials: M
authors.lastname: Berger
authors.forename: Sudhir
authors.initials: S
authors.lastname: Gupta
authors.forename: Leman
authors.initials: L
authors.lastname: Yel
authors.forename: Chaim M
authors.initials: CM
authors.lastname: Roifman
authors.forename: Ann
authors.initials: A
authors.lastname: Gardulf
authors.forename: Florian
authors.initials: F
authors.lastname: Eichmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Haag
authors.forename: Cordula
authors.initials: C
authors.lastname: Massion
authors.forename: Hans D
authors.initials: HD
authors.lastname: Ochs
mesh_terms: D000328:Adult; D002170:Canada; D002648:Child; D005260:Female; D018718:Home Infusion Therapy; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D008137:Longitudinal Studies; D008297:Male; D017060:Patient Satisfaction; D011788:Quality of Life; D012646:Self Administration; D012680:Sensitivity and Specificity; D014481:United States
chemical_list: D007074:Immunoglobulin G