title: Effect of chronic administration of fruit extract (Citrus unshiu Marc.) on glucose tolerance in GK rats, a model of type 2 diabetes.
abstract: Recent epidemiological studies have demonstrated that high dietary consumption of fruit and vegetables results in lower risks of diabetes. In this study, we investigated the effects of chronic administration of fruit extract (Citrus unshiu Marc.) on glucose tolerance in GK rats, a model of type 2 diabetes. After 10 weeks administration of the fruit extract, intraperitoneal glucose tolerance tests revealed significant decrements of blood glucose levels after glucose loading. Our findings further support an advantageous association of fruit consumption with diabetes.
authors.affiliation: Department of Citrus Research, National Institute of Fruit Tree Science, Shizuoka, Japan. msugiura@affrc.go.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Sugiura
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ogawa
authors.forename: Masamichi
authors.initials: M
authors.lastname: Yano
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002957:Citrus / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy*; D004195:Disease Models, Animal; D005638:Fruit / Q000737:chemistry*; D005951:Glucose Tolerance Test; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts