title: Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties.
abstract: Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy. Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed.
authors.affiliation: Microbiology and Immunology (M502), School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia.
authors.forename: C F
authors.initials: CF
authors.lastname: Carson
authors.forename: K A
authors.initials: KA
authors.lastname: Hammer
authors.forename: T V
authors.initials: TV
authors.lastname: Riley
mesh_terms: D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D031650:Melaleuca / Q000737:chemistry*; D008826:Microbial Sensitivity Tests / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D012874:Skin Diseases, Infectious / Q000188:drug therapy* / Q000209:etiology; D020947:Tea Tree Oil / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D020947:Tea Tree Oil