title: The disappearing nail bed: a possible outcome of onycholysis.
abstract: Onycholysis is a separation of the nail plate from the underlying and/or lateral supporting structures (hyponychium, nail bed, lateral nail folds). It is a commonly seen disorder that is usually asymptomatic. We have observed a number of cases of onycholysis in which the distal nail bed appeared to shrink. The nail bed becomes keratinized and produces dermatoglyphics like the normal tip of a digit. This may explain why it is difficult to promote reattachment. If onycholysis persists, the condition is more likely to become irreversible and form the "disappearing nail bed." The best chance of resolving onycholysis is to try to identify the causative agent and institute early therapy.
authors.affiliation: Department of Medicine (Dermatology), University of Mississippi Medical Center, Jackson, USA.
authors.forename: C Ralph
authors.initials: CR
authors.lastname: Daniel
authors.forename: Antonella
authors.initials: A
authors.lastname: Tosti
authors.forename: Matilde
authors.initials: M
authors.lastname: Iorizzo
authors.forename: Bianca Maria
authors.initials: BM
authors.lastname: Piraccini
mesh_terms: D004817:Epidermis / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000378:metabolism; D009260:Nail Diseases / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
chemical_list: D007633:Keratins