Nonlinear dose-effect relationship of different parameters in cancer cell lines.
The dose-effect curves of most parameters in cancer cell lines in response to x-irradiation or toxic agents are usually nonlinear. Such a nature is demonstrated in this article with cell lines of the immune system. However, the shape of the nonlinear dose-effect curves was found to be different for lymphocytes (EL-4) and macrophages (J774A.1). The mechanisms and implications are briefly discussed.
Liu
Shu-Zheng
SZ
Department of Radiation Biology, Jilin University, Norman Bethune Medical Center, Changchun, China. drliusz@yahoo.com
D000222:Adaptation, Physiological / Q000276:immunology / Q000502:physiology; D002273:Carcinogens / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects* / Q000276:immunology; D045744:Cell Line, Tumor / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D008264:Macrophages / Q000187:drug effects* / Q000528:radiation effects; D019055:No-Observed-Adverse-Effect Level; D014965:X-Rays
D002273:Carcinogens