Matched control study of efficacy of lymphocyte immunotherapy in donor oocyte recipients to support or refute the concept of need for histocompatibility antigen sharing of the couple for benefits.
OBJECTIVE
To determine if lymphocyte immunotherapy (LIT) improves outcome in recalcitrant donor oocyte recipients. If LIT was found to be similarly effective in this group, the theory of shared maternal/paternal histocompatibility antigens would seem less plausible because the donor oocyte introduces another group of histocompatibility antigens.


METHODS
Donor oocyte recipients with a history of failure to conceive despite at least two previous ETs using donor oocytes were given the option of having LIT. They were matched with the very next recipient who declined LIT therapy. Lymphocyte immunotherapy using the male partner's lymphocytes was given two weeks before transfer and twice more if pregnant.


RESULTS
Only three controls delivered versus recipients treated with LIT.


CONCLUSIONS
The fact that benefit from LIT extended to oocyte recipients challenges the concept that lymphocyte immunotherapy is most beneficial for couples sharing histocompatibility antigens.
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J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, USA.
Liss
J R
JR
Diantonio
A
A
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M L
ML
Duroseau
M
M
D016022:Case-Control Studies; D004624:Embryo Transfer; D005260:Female; D006648:Histocompatibility / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007247:Infertility, Female / Q000628:therapy*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009865:Oocytes / Q000276:immunology*; D011247:Pregnancy; D018873:Pregnancy Rate
D006649:Histocompatibility Antigens