title: Maintenance antipsychotic medication patterns in outpatient schizophrenia patients: a naturalistic cohort study.
abstract: OBJECTIVE
  Newer antipsychotics are increasingly used in schizophrenia maintenance. The UK change has been slow with little known on switching patterns. We aimed to investigate antipsychotic prescribing patterns in schizophrenia patients.
  
  
  METHODS
  A naturalistic six-site cohort sample of 600 patients were interviewed by researchers at 6-monthly intervals for 2 years to record their clinical and social functioning; use of services and medication for the preceding 6 months was obtained by structured extraction from clinical case notes.
  
  
  RESULTS
  Alterations in antipsychotic medication were frequent in this group, mainly during periods of inpatient care. Atypical prescribing increased steadily, though slowly, across the period. Polypharmacy was less than anticipated.
  
  
  CONCLUSIONS
  Inpatient care remains the main forum for switching of antipsychotics. The UK maintains a slow shift to atypical antipsychotics.
authors.affiliation: University of Oxford, Oxford, UK. tom.burns@psych.ox.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Burns
authors.forename: L
authors.initials: L
authors.lastname: Christova
authors.forename: S
authors.initials: S
authors.lastname: Cooper
authors.forename: G
authors.initials: G
authors.lastname: Harrison
authors.forename: J
authors.initials: J
authors.lastname: McKendrick
authors.forename: R
authors.initials: R
authors.lastname: Laugharne
authors.forename: T
authors.initials: T
authors.lastname: Obuaya
authors.forename: R
authors.initials: R
authors.lastname: McCreadie
authors.forename: S
authors.initials: S
authors.lastname: O'Brien
authors.forename: S
authors.initials: S
authors.lastname: Perrington
authors.forename: D
authors.initials: D
authors.lastname: Stephenson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D004059:Diffusion of Innovation; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy*; D012423:Rural Health; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012959:Socioeconomic Factors; D006113:United Kingdom; D014504:Urban Health
chemical_list: D014150:Antipsychotic Agents