title: Diagnostic and predictive value of CSF d-ROM level in influenza virus-associated encephalopathy.
abstract: The aim of this study was to assess the validity of serum and CSF oxidative status of patients with IE in their initial stage through the d-ROM (Diacron-Reactive Oxygen Metabolites, Italy) test, compared to those with other neurological diseases. The study was conducted on the following four groups: (1) influenza virus-associated encephalopathy (IE, n = 8), including four patients showing neurological sequelae or mortal; (2) influenza virus-associated febrile seizures (IFS, n = 11); (3) febrile convulsion (FC, n = 10): (4) enterovirus-associated encephalopathy (EE, n = 4), including one patient with neurological sequelae. The CSF d-ROM levels in the IE group were significantly higher than those in the IFS and the FC groups but not in the EE group. In addition, general laboratory findings such as leukocytes, platelets, C-reactive protein, aspartate aminotransferase, creatinine, creatinine kinase and LDH, including interleukin-6 (IL-6), were analyzed in each group. The CSF d-ROM levels in the IE group were significantly higher than those in the IFS and FC groups but not in the EE group. As for the serum d-ROM levels and general laboratory findings, with the exception of CSF IL-6 levels in IE, no significant differences were detected compared with the other groups. In patients with IE, the CSF d-ROM levels could be a valid predictive biomarker of the severity, and oxidative stress may be related to the pathogenesis of IE.
authors.affiliation: Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku, Tokyo, 160-0023, Japan. gaku@tokyo-med.ac.jp
authors.forename: Gaku
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Suganami
authors.forename: Chiako
authors.initials: C
authors.lastname: Watanabe
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Tasuku
authors.initials: T
authors.lastname: Miyajima
authors.forename: Kouji
authors.initials: K
authors.lastname: Takekuma
authors.forename: Satoshi
authors.initials: S
authors.lastname: Oguchi
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D018792:Encephalitis, Viral / Q000097:blood / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D005260:Female; D005609:Free Radicals / Q000097:blood / Q000134:cerebrospinal fluid*; D006801:Humans; D007251:Influenza, Human / Q000150:complications*; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D009975:Orthomyxoviridae / Q000276:immunology*; D018384:Oxidative Stress / Q000502:physiology; D010976:Platelet Count; D011237:Predictive Value of Tests; D017382:Reactive Oxygen Species / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D005609:Free Radicals; D015850:Interleukin-6; D017382:Reactive Oxygen Species