title: Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency.
abstract: With the introduction of automated assays for measuring serum cobalamin levels over the last decades, the hematological manifestations related to cobalamin deficiency have been changed from the description reported in 'old' studies or textbooks. We studied the hematological manifestations or abnormalities in 201 patients (median age: 67 +/- 6 years) with well-documented cobalamin deficiency (mean serum vitamin B12 levels 125 +/- 47 pg/ml) extracted from an observational cohort study (1995-2003). Assessment included clinical features, blood count and morphological review. Hematological abnormalities were reported in at least two-third of the patients: anemia (37%), leukopenia (13.9%), thrombopenia (9.9%), macrocytosis (54%) and hypegmented neutrophils (32%). The mean hemoglobin level was 10.3 +/- 0.4 g/dl and the mean erythrocyte cell volume 98.9 +/- 25.6 fl. Approximately 10% of the patients have life-threatening hematological manifestations with documented symptomatic pancytopenia (5%), 'pseudo' thrombotic microangiopathy (Moschkowitz; 2.5%), severe anemia (defined as Hb levels <6 g/dl; 2.5%) and hemolytic anemia (1.5%). Correction of the hematological abnormalities was achieved in at least two-thirds of the patients, equally well in patients treated with either intramuscular or oral crystalline cyanocobalamin. This study, based on real data from a single institution with a large number of consecutive patients with well-documented cobalamin deficiency, confirms several 'older' findings that were previously reported before the 1990s in several studies and in textbooks.
authors.affiliation: Department of Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. emmanuel.andres@chru-starsbourg.fr
authors.forename: E
authors.initials: E
authors.lastname: Andrès
authors.forename: S
authors.initials: S
authors.lastname: Affenberger
authors.forename: J
authors.initials: J
authors.lastname: Zimmer
authors.forename: S
authors.initials: S
authors.lastname: Vinzio
authors.forename: D
authors.initials: D
authors.lastname: Grosu
authors.forename: G
authors.initials: G
authors.lastname: Pistol
authors.forename: F
authors.initials: F
authors.lastname: Maloisel
authors.forename: T
authors.initials: T
authors.lastname: Weitten
authors.forename: G
authors.initials: G
authors.lastname: Kaltenbach
authors.forename: J-F
authors.initials: JF
authors.lastname: Blicklé
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D048429:Cell Size; D005260:Female; D005500:Follow-Up Studies; D006402:Hematologic Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000266:history / Q000473:pathology; D049673:History, 20th Century; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014805:Vitamin B 12 / Q000008:administration & dosage; D014806:Vitamin B 12 Deficiency / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000266:history / Q000473:pathology; D014803:Vitamin B Complex / Q000008:administration & dosage
chemical_list: D014803:Vitamin B Complex; D014805:Vitamin B 12