Anti-inflammatory activity of alkanoids and triterpenoids from Trichodesma amplexicaule Roth.
The phytochemical investigation of Trichodesma amplexicaule guided by bioassay, to isolation of triterpenoids and aliphatic phytoconstituents. To evaluate the anti-inflammatory activities of isolated phytoconstituents, models with carrageenan-induced acute arthritis and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The investigated results showed that alkanoic acid significantly inhibited the carrageenan-induced acute arthritis. Moreover, alkane also supressed the development of chronic arthritis induced by CFA. It has been reported that alkane was the major phytoconstituent (1.03 +/- 0.00135%) in in vivo studies.
Singh
B
B
Department of Botany, University of Rajasthan, Jaipur, India.
Sahu
P M
PM
Lohiya
R K
RK
Sharma
M K
MK
Singh
H L
HL
Singh
S
S
D000473:Alkanes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001681:Biological Assay / Q000379:methods; D028082:Boraginaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005620:Freund's Adjuvant / Q000633:toxicity; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000473:Alkanes; D000893:Anti-Inflammatory Agents; D014315:Triterpenes; D005620:Freund's Adjuvant; D007213:Indomethacin