title: Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives.
abstract: Novel 1,3,9-triazacyclopenta[b]fluorene-4,10-diones and 1,3,9-triazacyclopenta[b]fluorene, analogue of ellipticine, were synthesised, and evaluated in vitro for their antiproliferative activity on various breast cancer cell lines.
authors.affiliation: Laboratoire de Chimie Organique 1, UMR-CNRS 5181, Université Claude Bernard, Lyon 1, CPE, Bâtiment 308, 43 Boulevard du 11 Novembre 1918 69622, Villeurbanne cedex, France.
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Desforges
authors.forename: Laurent
authors.initials: L
authors.lastname: Picot
authors.forename: Cyril
authors.initials: C
authors.lastname: Montagne
authors.forename: Valérie
authors.initials: V
authors.lastname: Thiéry
authors.forename: Thierry
authors.initials: T
authors.lastname: Besson
authors.forename: Benoit
authors.initials: B
authors.lastname: Joseph
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D002227:Carbazoles; D005449:Fluorenes; D007093:Imidazoles