MAPKAP kinases - MKs - two's company, three's a crowd.
Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) - MK2, MK3 and MK5 - signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.
Gaestel
Matthias
M
Department of Biochemistry, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. gaestel.matthias@mh-hannover.de
D048948:14-3-3 Proteins / Q000378:metabolism; D020816:Amino Acid Motifs; D000818:Animals; D007249:Inflammation / Q000235:genetics; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D011487:Protein Conformation; D014158:Transcription, Genetic
D048948:14-3-3 Proteins; D020929:Mitogen-Activated Protein Kinase Kinases