title: Age of first faint in patients with vasovagal syncope.
abstract: BACKGROUND
  Understanding whether vasovagal syncope is a lifelong disorder might shed insight into its physiology and affect management strategies. Accordingly, we determined the age of the first syncopal spell in adult patients who sought care for syncope.
  
  
  RESULTS
  Patients were 42 +/- 18 years old with 64% women. They had had a median 8 syncope spells (interquartile range [IQR]: 4, 20) with a median frequency of 1.0 syncopal spells per year. The range of syncopal spells was 1-3,375, and the range of duration of history of syncope was 0.003-70 years. The first syncopal spell occurred at ages 0-81 in a skewed distribution, with a marked mode age of 13 years, a median age of 18 years (IQR 12, 37), and a mean age of 26 +/- 20 years. The distributions were statistically indistinguishable across countries (P = 0.50), among Canadian regions (P = 0.69), and between the studies (P = 0.49). The same modal values were seen in males and females, and in patients <40 and > or =40 years old. However, patients > or =40 years had median ages of onset older than patients <40 years (36 +/- 23 vs 17 +/- 8 years). Patients had a recalled history of syncopal spells of median duration of 10 years (IQR: 2, 23), with a range of 0.003-70 years. An age of onset <44 years was 86% accurate for vasovagal syncope.
  
  
  CONCLUSIONS
  The most common age at which vasovagal syncope first presents is 13 years, and patients remain at risk of syncope for many years. Lifelong coping strategies may be desirable.
authors.affiliation: Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada. sheldon@ucalgary.ca
authors.forename: Robert S
authors.initials: RS
authors.lastname: Sheldon
authors.forename: Aaron G
authors.initials: AG
authors.lastname: Sheldon
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Connolly
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Morillo
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingenheben
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Krahn
authors.forename: Mary-Lou
authors.initials: ML
authors.lastname: Koshman
authors.forename: Debbie
authors.initials: D
authors.lastname: Ritchie
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000416:Alberta / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D019462:Syncope, Vasovagal / Q000175:diagnosis / Q000453:epidemiology*; D018667:Tilt-Table Test; D013997:Time Factors