title: Effect of 0.5% apraclonidine on ptosis in Horner syndrome.
abstract: To demonstrate the effect of apraclonidine on anisocoria and ptosis in Horner syndrome, one drop of 0.5% apraclonidine was instilled in both eyes of 3 patients who presented with acute Horner syndrome, and the effect on ptosis and anisocoria was documented. As reported in the literature, one drop of 0.5% apraclonidine reverses the anisocoria of Horner syndrome. In addition, 0.5% apraclonidine leads to a complete resolution of the ptosis associated with Horner syndrome, a finding reported once in the literature. Apraclonidine is a safe and readily available alternative to cocaine for the diagnosis of Horner syndrome.
authors.affiliation: Division of Oculoplastics Surgery, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Garibaldi
authors.forename: Holly B
authors.initials: HB
authors.lastname: Hindman
authors.forename: Michael P
authors.initials: MP
authors.lastname: Grant
authors.forename: Nicholas T
authors.initials: NT
authors.lastname: Iliff
authors.forename: Shannath L
authors.initials: SL
authors.lastname: Merbs
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D015875:Anisocoria / Q000188:drug therapy / Q000209:etiology; D001763:Blepharoptosis / Q000188:drug therapy* / Q000209:etiology; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006732:Horner Syndrome / Q000150:complications*; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions
chemical_list: D000316:Adrenergic alpha-Agonists; D009883:Ophthalmic Solutions; C016986:apraclonidine; D003000:Clonidine