Adenocarcinoma of the uterine cervix with choriocarcinomatous metastasis.
BACKGROUND
Nongestational choriocarcinoma, in very rare instances, has been described as a component of other malignancies with a tendency for a very poor prognosis.


METHODS
A 55 year old woman was diagnosed with adenocarcinoma of the cervix, and incompletely treated with only external beam radiation. Adjuvant radical hysterectomy demonstrated no residual tumor, but the patient developed a tumor metastasis mimicking a pulmonary artery thrombus which by histology and immunohistochemistry was pure choriocarcinoma. While chemotherapy was successful in achieving a complete remission, the patient succumbed to complications of her pulmonary metastasis.


CONCLUSIONS
Choriocarcinomatous dedifferentiation of cervical adenocarcinoma is extremely rare, with only one other case reported in the literature. While the prognosis for patients with such a tumor is generally poor, aggressive combination chemotherapy may be of benefit in some.
Pavelka
James C
JC
The Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 160 W, Los Angeles, CA 90048, USA. pavelkaj@cshs.org
Bryant
David A
DA
Vaccarello
Luis
L
D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy; D002822:Choriocarcinoma / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D014594:Uterine Neoplasms / Q000556:secondary*