title: [Liver metastasis from sigmoid colon cancer with peritoneal dissemination showed a complete response to TS-1].
abstract: A 64-year-old man with unresectable sigmoid adenocarcinoma due to peritoneal dissemination (P3) and liver metastasis (H2) treated with TS-1, showed a complete response. TS-1 is an oral anticancer drug that produces biochemical modulation. It is composed of tegafur, gimestat and ostat potassium in a molar ratio of 1:0.4:1 to increase the effect of 5-FU and to decrease toxicity in the digestive canal. Treatment with TS-1 requires no hospitalization and can enhance the quality of life of the patient. TS-1 is expected to be an effective agent for the treatment of colon cancer with liver metastasis and peritoneal dissemination.
authors.affiliation: Dept. of Surgery, Division of General and Gastroenterological Surgery, Toho University School of Medicine.
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Akira
authors.initials: A
authors.lastname: Seo
authors.forename: Natsuki
authors.initials: N
authors.lastname: Tokura
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Honda
authors.forename: Hajime
authors.initials: H
authors.lastname: Kase
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Teramoto
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D014408:Biomarkers, Tumor / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D011725:Pyridines / Q000008:administration & dosage*; D012074:Remission Induction; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid