title: Aldosterone and telomere length in white blood cells.
abstract: BACKGROUND
  Aldosterone accelerates cardiovascular aging by mechanisms that generate reactive oxygen species. Telomere length in white blood cells (WBCs) may be a bioindicator that registers the accruing burden of systemic oxidative stress. The aim of the present study was, therefore, to examine the relationship between plasma aldosterone and telomere length in WBCs.
  
  
  METHODS
  We studied 75 normotensive and never-treated mildly hypertensive men whose blood was drawn for the measurements of plasma aldosterone concentration and the terminal restriction fragment (TRF) length in WBCs.
  
  
  RESULTS
  The slope of the TRF-age relationship in the entire cohort showed a decrease in telomere length of 26 +/- 5 base pairs per year (r = -0.46, p <.001). Age-adjusted TRF length was the longest in the lowest aldosterone quartile (6.74 +/- 0.12 kb) and shortest in the highest aldosterone quartile (6.36 +/- 0.11 kb), with intermediate TRF lengths in the second and third aldosterone quartiles (analysis of variance [ANOVA] trend test, p =.025). In telomeric attrition equivalence, participants in the upper aldosterone quartile were 15 years older than their peers in the lowest quartile.
  
  
  CONCLUSIONS
  The inverse relationship between aldosterone and WBC telomere length suggests not only that aldosterone is pro-oxidant but that elevated concentrations of this hormone might be linked to a higher rate of telomere attrition and perhaps increased biological aging in humans.
authors.affiliation: INSERM Unit 684, University of Nancy, 54511 Nancy-les-Vandoeuvre, France. a.benetos@chu-nancy.fr
authors.forename: Athanase
authors.initials: A
authors.lastname: Benetos
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Gardner
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kimura
authors.forename: Carlos
authors.initials: C
authors.lastname: Labat
authors.forename: Rosine
authors.initials: R
authors.lastname: Nzietchueng
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dousset
authors.forename: Faiez
authors.initials: F
authors.lastname: Zannad
authors.forename: Patrick
authors.initials: P
authors.lastname: Lacolley
authors.forename: Abraham
authors.initials: A
authors.lastname: Aviv
mesh_terms: D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D006801:Humans; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D016615:Telomere / Q000648:ultrastructure*
chemical_list: D000450:Aldosterone