Towards a multidisciplinary and integrated strategy in the assessment of adverse health effects related to air pollution: the case study of Cracow (Poland) and asthma.
Complex interaction between anthropogenic activities, air quality and human health in urban areas, such as in Cracow sustains the need for the development of an interdisciplinary and integrated risk-assessment methodology. In such purpose, we propose a pilot study performed on asthmatics and based on a combined use of a biomarker, such as metallothionein 2A (MT-2A) in the characterization of human exposure to one or a mixture of pollutants and of Geographical Information Systems (G.I.S.) which integrates climatic and urban anthropogenic parameters in the assessment of spatio-temporal dispersion of air pollutants. Considering global incidence of air pollution on asthma and on peripheral blood lymphocytes MT-2A expression should provide a complementary information on biological risks linked to urban anthropogenic activities. Such study would help for the establishment of a sustainable development in urban areas that can maintain the integrity of air quality and preserve human health.
Oudinet
Jean-Paul
JP
Centre de Biogéographie-Ecologie FRE 2545 CNRS, Maison de la recherche, Université Paris-Sorbonne, Paris IV, 28 rue Serpente, 75006 Paris, France. biogeo@paris4.sorbonne.fr
Méline
Julie
J
Chełmicki
Wojciech
W
Sanak
Marek
M
Magdalena
Dutsch-Wicherek
DW
Besancenot
Jean-Pierre
JP
Wicherek
Stanislas
S
Julien-Laferrière
Bertrand
B
Gilg
Jean-Paul
JP
Geroyannis
Hélène
H
Szczeklik
Andrew
A
Krzemień
Kazimierz
K
D000392:Air Movements; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002947:Cities; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D040362:Geographic Information Systems; D006801:Humans; D008668:Metallothionein / Q000097:blood; D011044:Poland; D018570:Risk Assessment / Q000379:methods; D014504:Urban Health
D015415:Biomarkers; C491053:MT2A protein, human; D008668:Metallothionein