Autoimmune hemolytic anemia in an elderly patient with primary Sjögren's syndrome.
Primary Sjögren's syndrome is an autoimmune disease characterized by lymphocytic infiltration of the salivary glands and lacrimal glands. The histological features of chronic inflammation in primary Sjögren's syndrome may be associated with B cell hyper-reactivity. This syndrome also has various manifestations associated with other exocrine glands and nonglandular tissues. The hematological abnormalities usually seen in Sjögren's syndrome are lymphopenia, leucopenia, and thrombocytopenia. Although the direct Coomb's test is often positive, the occurrence of autoimmune hemolytic anemia (AIHA) is rare. Here, we report an elderly patient with primary Sjögren's syndrome who developed AIHA during the clinical course.
Kikawada
Masayuki
M
Department of Geriatric Medicine, Tokyo Medical University, Japan.
Watanabe
Daisuke
D
Kimura
Akihiro
A
Hanyu
Haruo
H
Serizawa
Hiromi
H
Iwamoto
Toshihiko
T
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D001706:Biopsy; D003298:Coombs Test; D003937:Diagnosis, Differential; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology