The APOA4 Thr347->Ser347 polymorphism is not a major risk factor of obesity.
OBJECTIVE
The goal of this study was to assess the association between the APOA4 Thr(347)-->Ser(347) polymorphism and BMI and obesity.


METHODS
Men and women (n = 3320), randomly recruited in three independent population surveys from the north, east, and south of France, were genotyped for the APOA4 Thr(347)-->Ser(347) polymorphism.


RESULTS
There were 1327 overweight (825 men, 502 women) and 611 obese (313 men, 298 women) subjects. The prevalences of subjects carrying at least one Ser(347) allele (*/Ser(347)) were 36.5%, 33.8%, and 34.3% in controls, overweight, and obese subjects, respectively (not significant), and those of the Ser(347)/Ser(347) genotype were 4.5%, 3.0%, and 2.2%, respectively (not significant). In both men and women, mean BMI and body weight were not significantly different among APOA4 genotypes. There was no evidence of heterogeneity among centers, smoking status, alcohol intake, physical activity, and educational level categories. In men, mean waist girth was lower in Ser(347)/Ser(347) (92.2 +/- 9.4 cm) than in Thr(347) carriers (95.9 +/- 10.9 cm; p = 0.01), and plasma triglycerides levels were lower in Ser(347) (1.41 +/- 1.04 mM) than in Thr(347)/Thr(347) carriers (1.55 +/- 1.23 mM; p = 0.01).


CONCLUSIONS
These results suggest that the APOA4 347Ser allele is not a major risk factor for obesity or overweight.
Dallongeville
Jean
J
INSERM U 508, Institut Pasteur de Lille, France. jean.dallongeville@pasteur-lille.fr
Delcroix
Anne-Gaëlle
AG
Wagner
Aline
A
Ducimetière
Pierre
P
Ruidavets
Jean-Bernard
JB
Arveiler
Dominique
D
Bingham
Annie
A
Ferrières
Jean
J
Amouyel
Philippe
P
Meirhaeghe
Aline
A
D000328:Adult; D000483:Alleles; D001054:Apolipoproteins A / Q000235:genetics*; D015992:Body Mass Index; D015444:Exercise; D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors; D012694:Serine; D013912:Threonine
D001054:Apolipoproteins A; D008055:Lipids; D008074:Lipoproteins; C022205:apolipoprotein A-IV; D013912:Threonine; D012694:Serine