Comparative study of different formulations of atenolol.
Tablets are the most common dosage form. Tablets can be prepared by dry method and wet methods, both methods have their own significance as well as disadvantages. Dry method and particularly direct compression is most simplest method of tablet manufacturing. On the other hand granulation is a multiple processing method which add complexity and make validation and control difficult. For comparative study of atenolol tablets a new formulation was designed and compressed by direct compression method. Then it's physical parameters including hardness, friability, diameter, thickness, disintegration time, dissolution test were performed and finally assay carried out for evaluation and characterization of this new formulation against other formulation available in the market.
Yasmeen
Riffat
R
Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Shoaib
M Harris
MH
Khalid
Halima
H
D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D001262:Atenolol / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000319:Adrenergic beta-Antagonists; D005079:Excipients; D001262:Atenolol