Seroepidemiology of strongyloidiasis in the Peruvian Amazon.
A stool and serosurvey for Strongyloides stercoralis was conducted in a community in the Peruvian Amazon region. Strongyloidiasis stercoralis was identified in the stool of 69 (8.7%) of 792 participants. Six hundred nine sera were tested using by an enzyme-linked immunosorbent assay (ELISA), which had a sensitivity of 92% and a specificity of 94%; 442 (72%) were positive. In multivariable logistic regression models, having S. stercoralis in stool was associated with hookworm in the same specimen (odds ratio [OR] = 4.44, 95% confidence interval [CI] = 2.02-9.79), occasionally or never wearing shoes (OR = 1.89, 95% CI = 1.10-3.27), and increasing age (OR = 1.012 for each one-year increase, 95% CI = 1.00-1.03). Similarly, occasionally or never wearing shoes (OR = 1.54, 95% CI = 1.01-2.37) and increasing age (OR = 1.04 for each one-year increase, 95% CI = 1.02-1.06) were associated with an increased risk of a positive S. stercoralis ELISA result. The ELISA had a negative predictive value of 98% and is an excellent screening test for strongyloidiasis.
Yori
Pablo P
PP
Asociacion Benefica PRISMA, Lima, Peru.
Kosek
Margaret
M
Gilman
Robert H
RH
Cordova
Julianna
J
Bern
Caryn
C
Chavez
Cesar Banda
CB
Olortegui
Maribel Paredes
MP
Montalvan
Carmen
C
Sanchez
Graciela Meza
GM
Worthen
Bevelle
B
Worthen
James
J
Leung
Fay
F
Oré
Carlos Vidal
CV
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D005260:Female; D005368:Filariasis / Q000175:diagnosis; D006725:Hookworm Infections / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010568:Peru / Q000453:epidemiology; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012775:Shoes; D017171:Strongyloides stercoralis / Q000276:immunology / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000097:blood / Q000453:epidemiology* / Q000276:immunology