title: Non-pigmented fixed drug eruption induced by eprazinone hydrochloride.
abstract: A 68-year-old woman developed an upper respiratory tract infection in November 2002 and was treated with eprazinone hydrochloride, serrapeptase, carbocysteine and clarithromycin. Three days after the start of treatment, the patient noted erythema on her axilla, buttock and inguinal regions. The erythema subsided in 7 days although slight pigmentation remained. However, 7 days later the pigmentation completely disappeared. Oral eprazinone hydrochloride was given as a challenge, and 1 day later the erythema re-appeared in the same areas as on initial presentation (axilla, buttock, and inguinal regions). A fixed erythema without lasting pigmentation is attributed to eprazinone hydrochloride. Therefore, the patient was diagnosed as having a nonpigmented fixed drug eruption associated with eprazinone hydrochloride.
authors.affiliation: Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tanabe
authors.forename: Hiromi
authors.initials: H
authors.lastname: Tsuboi
authors.forename: Hideki
authors.initials: H
authors.lastname: Maejima
authors.forename: Satoru
authors.initials: S
authors.lastname: Arai
authors.forename: Kensei
authors.initials: K
authors.lastname: Katsuoka
mesh_terms: D000368:Aged; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D011427:Propiophenones / Q000009:adverse effects*
chemical_list: D011427:Propiophenones; C007608:eprazinone