Low triiodothyronine (T3) or reverse triiodothyronine (rT3) syndrome modifies gene expression in rats with congestive heart failure.
Heart failure (HF) is frequently associated with euthyroid "sick" syndrome (low T3 and elevated rT3). We investigated if altered thyroid hormone in HF could affect expression of the TH receptor (TRalpha1), and alpha and beta myosin heavy chains (alpha-MHC, beta-MHC). HF was provoked in rats by aortic stenosis. We showed that rT3 generated from liver and kidney deiodination significantly increased and T3 decreased in HF; there was significantly higher TRalpha1 expression, no alpha-MHC expression, but beta-MHC expression. Changes in TRalpha could be compensating for low T3 from HF.
Bauab
R C M
RC
Division of Endocrinology and Cardiology, Department of Internal Medicine, University Estadual Paulista, Medical School, Botucatu, São Paulo, Brazil.
Perone
D
D
Castro
A V B
AV
Cicogna
A C
AC
Nogueira
C R
CR
D000818:Animals; D005067:Euthyroid Sick Syndromes / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006333:Heart Failure / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D006352:Heart Ventricles / Q000378:metabolism; D008297:Male; D018995:Myosin Heavy Chains / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018709:Statistics, Nonparametric; D037021:Thyroid Hormone Receptors alpha / Q000096:biosynthesis / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D014284:Triiodothyronine / Q000172:deficiency* / Q000378:metabolism; D014285:Triiodothyronine, Reverse / Q000378:metabolism*
D012333:RNA, Messenger; D037021:Thyroid Hormone Receptors alpha; D016212:Transforming Growth Factor beta; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D018995:Myosin Heavy Chains