title: Feasibility of familial PSA screening: psychosocial issues and screening adherence.
abstract: This study examined factors that predict psychological morbidity and screening adherence in first-degree relatives (FDRs) taking part in a familial PSA screening study. Prostate cancer patients (index cases - ICs) who gave consent for their FDRs to be contacted for a familial PSA screening study to contact their FDRs were also asked permission to invite these FDRs into a linked psychosocial study. Participants were assessed on measures of psychological morbidity (including the General Health Questionnaire; Cancer Worry Scale; Health Anxiety Questionnaire; Impact of Events Scale); and perceived benefits and barriers, knowledge; perceived risk/susceptibility; family history; and socio-demographics. Of 255 ICs, 155 (61%) consented to their FDRs being contacted. Of 207 FDRs approached, 128 (62%) consented and completed questionnaires. Multivariate logistic regression revealed that health anxiety, perceived risk and subjective stress predicted higher cancer worry (P = 0.05). Measures of psychological morbidity did not predict screening adherence. Only past screening behaviour reliably predicted adherence to familial screening (P = 0.05). First-degree relatives entering the linked familial PSA screening programme do not, in general, have high levels of psychological morbidity. However, a small number of men exhibited psychological distress.
authors.affiliation: Academic Department of Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK.
authors.forename: J
authors.initials: J
authors.lastname: Sweetman
authors.forename: M
authors.initials: M
authors.lastname: Watson
authors.forename: A
authors.initials: A
authors.lastname: Norman
authors.forename: Z
authors.initials: Z
authors.lastname: Bunstead
authors.forename: P
authors.initials: P
authors.lastname: Hopwood
authors.forename: J
authors.initials: J
authors.lastname: Melia
authors.forename: S
authors.initials: S
authors.lastname: Moss
authors.forename: R
authors.initials: R
authors.lastname: Eeles
authors.forename: D
authors.initials: D
authors.lastname: Dearnaley
authors.forename: C
authors.initials: C
authors.lastname: Moynihan
mesh_terms: D000368:Aged; D001007:Anxiety; D015438:Health Behavior; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D009017:Morbidity; D010349:Patient Compliance; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000523:psychology*; D011594:Psychometrics; D013315:Stress, Psychological
chemical_list: D017430:Prostate-Specific Antigen