title: Evaluation of the topical effect of alendronate on the root surface of extracted and replanted teeth. Microscopic analysis on rats' teeth.
abstract: The treatment of choice for tooth avulsion is replantation. The ideal replantation should be realized as quickly as possible, or at least, the avulsed tooth should be kept in an adequate solution to preserve the periodontal ligament attached to the root. If that is not possible, treatment of the radicular surface should be done in order to prevent radicular resorption. The purpose of this study was to test sodium alendronate as a substance for topical treatment of the radicular surface of avulsed teeth in an attempt to prevent the occurrence of dental resorptions. Fifty-four rat maxillary right central incisors were extracted and replanted. Group I--extra-alveolar dry period of 15 min, intracanal dressing with calcium hydroxide (CALEN, S.S. White, Artigos Dentários LTDA, Rio de Janeiro, Brazil) and replantation; Groups II and III - extra-alveolar dry periods of 30 and 60 min, respectively, immersion in 1% sodium hypochlorite for 30 min for removal of the periodontal ligament, washing in saline solution for 5 min, and treatment of the radicular surface with 3.2 mg/l sodium alendronate solution for 10 min. Intracanal dressing with calcium hydroxide and replantation followed. At 15, 60, and 90 days post-reimplantation, the animals were killed and the samples obtained and processed for microscopic analysis. The results indicated that sodium alendronate was able to reduce the incidence of radicular resorption, but not of dental ankylosis. No significant differences were observed regarding variations in the extra-alveolar periods among the groups.
authors.affiliation: Department of Endodontics, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil. adrianalustosa2003@yahoo.com.br
authors.forename: Adriana
authors.initials: A
authors.lastname: Lustosa-Pereira
authors.forename: Roberto Brandão
authors.initials: RB
authors.lastname: Garcia
authors.forename: Ivaldo Gomes
authors.initials: IG
authors.lastname: de Moraes
authors.forename: Norberti
authors.initials: N
authors.lastname: Bernardineli
authors.forename: Clovis Monteiro
authors.initials: CM
authors.lastname: Bramante
authors.forename: Eduardo Antunes
authors.initials: EA
authors.lastname: Bortoluzzi
mesh_terms: D019386:Alendronate / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003890:Desiccation; D008297:Male; D051381:Rats; D012390:Root Canal Therapy; D012391:Root Resorption / Q000517:prevention & control*; D020254:Tooth Ankylosis / Q000517:prevention & control; D014090:Tooth Replantation; D014092:Tooth Root / Q000187:drug effects*
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate