title: Effect of cimetidine, ranitidine and tiotidine on plasma testosterone and luteinizing hormone levels in rats.
abstract: This investigation was carried out to study the comparative effects of cimetidine, ranitidine and tiotidine on the plasma levels of testosterone and luetinizing hormone under local conditions. The three H(2)-blocking drugs were injected to the adult male albino rats twice daily at the recommended therapeutic dose levels for six weeks. The data obtained showed that only tiotidine caused a significant (<0.05) increase in the level of testosterone. However, all the three drugs caused a significant rise in the levels of luteinizing hormone with the most active ranitidine administration.
authors.affiliation: Department of Pharmacology, Punjab Medical College, Faisalabad.
authors.forename: R T
authors.initials: RT
authors.lastname: Mahmud
authors.forename: M S
authors.initials: MS
authors.lastname: Akhter