Influence of D-arabitol and ribitol on neuronal network activity.
To date, two new defects in the pentose phosphate pathway have been identified in patients with abnormalities in their polyol profiles. Some of them presented with neurological symptoms of so far unknown aetiology. The pathophysiological role of polyols, e.g. in the brain, is relatively unknown. We tested the neurotoxicity of polyols using a 'neurochip' model. After exposure of cortical rat neurons to D-arabitol and ribitol in increasing concentrations up to 10 mmol/L, the electrophysiological activity was measured. No acute effect on the spontaneous network activity of cortical neurons was observed. We speculate that polyols have only secondary effects on brain dysfunction.
Klusmann
A
A
Department of General Pediatrics, University Children's Hospital, Moorenstrasse 5, D-40225 Duesseldorf, Germany. Klusmann@med.uni-duesseldorf.de
Fleischer
W
W
Waldhaus
A
A
Siebler
M
M
Mayatepek
E
E
D000818:Animals; D001921:Brain / Q000378:metabolism; D050260:Carbohydrate Metabolism; D015925:Cryopreservation; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology; D009415:Nerve Net; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D012255:Ribitol / Q000378:metabolism*; D013402:Sugar Alcohols / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology
D013402:Sugar Alcohols; D013779:Tetrodotoxin; D012255:Ribitol; D008012:Lidocaine; C014999:arabitol