Platelet FcgammaRIIA expression is associated with the alpha2 integrin C807T gene polymorphism in type 2 diabetes.
"Patelet" FcgammaRIIA is stably overexpressed in type 2 diabetes and may also play a role in collagen-mediated platelet activation. Platelet surface integrin a(2)ss(1)-collagen interaction is an early step associated with platelet adhesion and activation and plays an important role in arterial thrombosis. The objective of this study was to characterize the relationship in diabetes and non-diabetes platelets between FcgammaRIIA expression and a polymorphism associated with arterial thrombotic events, polymorphism C807T on the gene encoding a(2)ss(1). Platelet flow cytometry and allele-specific PCR revealed a significant correlation in type 2 diabetes between low platelet FcgammaRIIA expression and the 807TT genotype that is associated with increased platelet a(2)ss(1) receptor density. We conclude that uni- or bi-directional modulation of surface expression may exist between the platelet FcgammaRIIA receptor and a a(2)ss(1) thrombogenic polymorphism that could play a role in platelet sensitivity to collagen in type 2 diabetes.
Calverley
David C
DC
Department of Medicine, University of Colorado, Denver, USA. david.calverley@uchsc.edu
Baldermann
Lyndy V
LV
Moran
Kathleen
K
Chen
Nancy N
NN
McFann
Kim
K
D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D005838:Genotype; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D013927:Thrombosis / Q000235:genetics
D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D038982:Integrin alpha2beta1; D017452:Receptors, IgG