Diacylglycerol-enriched structured lipids containing CLA and capric acid alter body fat mass and lipid metabolism in rats.
OBJECTIVE
The present study compared the effect of corn oil, diacylglycerol (DG) oil, and DG-enriched structured lipids (SL-DG) produced from corn oil, capric and conjugated linoleic acid on adiposity in rats fed an AIN-76 diet (5% fat) for 6 weeks.


METHODS
The plasma and hepatic lipids, adipose tissue weight, and enzyme activities related to fatty acid metabolism were determined.


RESULTS
The weights of the epididymal white adipose tissue (WAT), perirenal WAT, and interscapular WAT were significantly lower in the SL-DG group than in the DG group. Reduction of fat mass in the SL-DG group was related to suppressing fatty acid synthase activities and enhancing beta-oxidation activity in perirenal WAT. The plasma leptin was lower in the SL-DG group than in the DG group, plus a lower plasma TG level was accompanied by an increase in adipocyte LPL activity. Meanwhile the SL-DG supplement lowered the plasma and hepatic cholesterol level. In addition, the hepatic HMG-CoA reductase and ACAT activities were significantly lower in the SL-DG group than in the other groups.


CONCLUSIONS
The DG-enriched SL used in this study was effective in enhancing triglyceride metabolism in adipose tissue, especially as regards reducing the abdominal fat mass and cholesterol metabolism in the liver.
Kim
Hye-Jin
HJ
Department of Food Science and Nutrition, Kyungpook National University, Daegu, Korea.
Lee
Ki-Teak
KT
Lee
Mi-Kyung
MK
Jeon
Seon-Min
SM
Choi
Myung-Sook
MS
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003314:Corn Oil; D003652:Decanoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D004075:Diglycerides / Q000008:administration & dosage / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000378:metabolism; D020738:Leptin / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D003652:Decanoic Acids; D004075:Diglycerides; D020738:Leptin; D044243:Linoleic Acids, Conjugated; D014280:Triglycerides; C031071:decanoic acid; D003314:Corn Oil; D064429:Fatty Acid Synthases; D008071:Lipoprotein Lipase