Dissolution characteristics of cylindrical particles and tablets.
In this paper, dissolution characteristics of primary-particles and compressed tablets were investigated by experiments using a mathematical model. For the primary-particle, it was found that the dissolution rate increased with a decrease in the particle size. Assuming that primary-particles of size distribution were of cylindrical shape and that the dissolution occurs from the total external surface, an extended Nernst-Noyes-Whitney equation fitted to the experimental data well. As the influences of particle size and shape on thickness of a diffusion-boundary film were found to be quite low, the dissolution rate was considered to be affected by the specific surface area dominantly. Furthermore, the same model was applied to a compressed tablet and fitted to the data well. Though the rate constant obtained were not affected by the properties of primary-particles forming the tablet, it was found to increase with the apparent voidage which occupies the inter-particle volume of tablet diluent among less soluble particles. Consequently, an increase in the apparent voidage is presumed to accelerate penetration of water into the internal voids of the tablet. Thus, the dissolution going, the effective surface area inside the tablet is considered to be extended.
Fukunaka
Tadashi
T
Banyu Pharmaceutical Co., Ltd. 9-1, Kamimutsuna 3-Chome, Okazaki, Aichi 444-0858, Japan. tadashi_fukunaka@merck.com
Yaegashi
Yoshiko
Y
Nunoko
Taku
T
Ito
Ryusei
R
Golman
Boris
B
Shinohara
Kunio
K
D007700:Kinetics; D007785:Lactose / Q000737:chemistry; D008956:Models, Chemical; D010316:Particle Size; D012457:Salicylamides / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D012457:Salicylamides; D013607:Tablets; D014867:Water; D007785:Lactose; C018935:ethenzamide