Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults.
BACKGROUND
Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression.


OBJECTIVE
We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study.


METHODS
Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up.


RESULTS
sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events.


CONCLUSIONS
While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.
Jenny
N S
NS
Department of Pathology, College of Medicine, University of Vermont, Burlington, VT, USA.
Arnold
A M
AM
Kuller
L H
LH
Sharrett
A R
AR
Fried
L P
LP
Psaty
B M
BM
Tracy
R P
RP
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000097:blood / Q000453:epidemiology / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D009026:Mortality; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000401:mortality; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D012995:Solubility; D020521:Stroke / Q000097:blood / Q000453:epidemiology / Q000401:mortality
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1