title: Evaluation of CD7 and terminal deoxynucleotidyl transferase (TdT) expression in CD34+ myeloblasts from patients with myelodysplastic syndrome.
abstract: There is an emerging use of flow cytometry to evaluate patients with myelodysplastic syndrome (MDS). We have studied CD7 and TdT expression in the CD34+ myeloid blast cell population in 55 bone marrow samples of patients with MDS. CD7 and/or TdT were detected in 38 out of 55 patients (69%). CD7 expression was not related to other bad prognosis data but conversely, we found an association between TdT+ CD34 myeloblasts and high-risk MDS patients according to the International Prognostic Scoring System. Therefore, CD7 and TdT may help to establish the diagnosis of MDS and, TdT expression also seems to be a useful marker in distinguishing risk groups.
authors.affiliation: Department of Haematology, Clínica Moncloa, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Font
authors.forename: D
authors.initials: D
authors.lastname: Subirá
authors.forename: C
authors.initials: C
authors.lastname: Mtnez-Chamorro
authors.forename: S
authors.initials: S
authors.lastname: Castañón
authors.forename: E
authors.initials: E
authors.lastname: Arranz
authors.forename: S
authors.initials: S
authors.lastname: Ramiro
authors.forename: J J
authors.initials: JJ
authors.lastname: Gil-Fernández
authors.forename: J
authors.initials: J
authors.lastname: López-Pascual
authors.forename: A
authors.initials: A
authors.lastname: Alonso
authors.forename: M A
authors.initials: MA
authors.lastname: Pérez-Sáenz
authors.forename: C
authors.initials: C
authors.lastname: Alaez
authors.forename: M
authors.initials: M
authors.lastname: Renedo
authors.forename: C
authors.initials: C
authors.lastname: Blas
authors.forename: A
authors.initials: A
authors.lastname: Escudero
authors.forename: J M
authors.initials: JM
authors.lastname: Fdez-Rañada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000096:biosynthesis*; D019011:Antigens, CD7 / Q000032:analysis / Q000096:biosynthesis*; D020732:Cytogenetic Analysis; D004253:DNA Nucleotidylexotransferase / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D042381:Granulocyte Precursor Cells / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000276:immunology*; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D018952:Antigens, CD34; D019011:Antigens, CD7; D004253:DNA Nucleotidylexotransferase