Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing.
Ethanolic extract of leaves of O. sanctum was investigated for normal wound healing and dexamethasone depressed healing using incision, excision and dead space wound models in albino rats. The extract of O. sanctum significantly increased the wound breaking strength in incision wound model. The extract treated wounds were found to epithelialize faster and the rate of wound contraction was significantly increased as compared to control wounds. Significant increase in wet and dry granulation tissue weight, granulation tissue breaking strength and hydroxyproline content in dead space wound model was observed. The extract significantly decreased the antihealing activities of dexamethasone in all the wound models. The results indicated that the leaf extract promotes wound healing significantly and able to overcome the wound healing suppressing action of dexamethasone. Histological examination of granulation tissue to determine the pattern of lay-down for collagen confirmed the results.
Udupa
S L
SL
Department of Biochemistry, Kasturba Medical College, Manipal 576 104, India. s_udupa@yahoo.com
Shetty
Somashekar
S
Udupa
A L
AL
Somayaji
S N
SN
D000818:Animals; D003907:Dexamethasone / Q000633:toxicity; D005260:Female; D008297:Male; D031339:Ocimum; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000473:pathology
D010936:Plant Extracts; D003907:Dexamethasone