title: Toxic epidermal necrolysis in systemic lupus erythematosus.
abstract: Toxic epidermal necrolysis (TEN) is an acute, rapidly evolving mucocutaneous reaction with a high mortality rate characterized by extensive painful cutaneous and mucosal exfoliation and systemic involvement that is frequently associated with medication use. The treatment of this condition is controversial. Systemic lupus erythematosus (SLE) is a generalized autoimmune disease of unknown etiology characterized by the production of autoantibodies to self antigens. Several case reports in the literature have demonstrated an association between SLE and TEN, and it has been postulated that lupus-associated TEN may exist. In this review, we will explore the association of SLE and TEN, and its diagnosis and treatment.
authors.affiliation: Nassau University Medical Center, East Meadow, New York, USA. nshorne@yahoo.com
authors.forename: Nathanael S
authors.initials: NS
authors.lastname: Horne
authors.forename: Archana R
authors.initials: AR
authors.lastname: Narayan
authors.forename: Rose-Marie
authors.initials: RM
authors.lastname: Young
authors.forename: Marianne
authors.initials: M
authors.lastname: Frieri
mesh_terms: D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D013256:Steroids / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D013256:Steroids