title: Genetic variation in DTNBP1 influences general cognitive ability.
abstract: Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.
authors.affiliation: Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA. kburdick@lij.edu
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Burdick
authors.forename: Todd
authors.initials: T
authors.lastname: Lencz
authors.forename: Birgit
authors.initials: B
authors.lastname: Funke
authors.forename: Christine T
authors.initials: CT
authors.lastname: Finn
authors.forename: Philip R
authors.initials: PR
authors.lastname: Szeszko
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
authors.forename: Raju
authors.initials: R
authors.lastname: Kucherlapati
authors.forename: Anil K
authors.initials: AK
authors.lastname: Malhotra
mesh_terms: D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D003071:Cognition; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005819:Genetic Markers; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000235:genetics / Q000523:psychology; D012559:Schizophrenia / Q000235:genetics; D012565:Schizophrenic Psychology
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005819:Genetic Markers