Elevated levels of inducible heat shock 70 proteins in human brain.
Differential expression of heat shock genes can modulate protein folding and stress-related cell death. There have been no comparisons of their levels of expression in animals and humans. Levels of expression of heat shock 70 genes in human brain were compared to levels in non-stressed and heat-stressed brain of rat. Levels of hsp70 proteins in human brain were 43-fold higher than in non-stressed rat brain and 14-fold higher than highest induced levels in brains of heat-shocked rats. Levels of constitutively synthesized hsc70 proteins were approximately 1.5-fold higher in human than in rat. Higher levels of hsp70 proteins in human brain may serve to protect brain cells against stress-related death or dysfunction throughout the lifespan.
Pardue
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Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, United States.
Wang
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S
Miller
M M
MM
Morrison-Bogorad
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M
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002102:Cadaver; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013312:Stress, Physiological / Q000378:metabolism*; D014018:Tissue Distribution
D018840:HSP70 Heat-Shock Proteins