title: Hippocampal atrophy in Alzheimer disease: age matters.
abstract: Hippocampal atrophy is a marker of Alzheimer disease (AD). It remains unclear whether this holds true for younger patients as well. Hippocampal volume was measured on MRI scans of 103 clinically diagnosed AD patients and 73 controls (aged 51 to 85 years). Aging and AD were independently associated with smaller hippocampal volume. Both young and old AD patients have hippocampal atrophy abnormal for age. Age-dependent criteria for hippocampal atrophy, suggestive of AD, are needed.
authors.affiliation: Department of Neurology, Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands. L.vandepol@vumc.nl
authors.forename: L A
authors.initials: LA
authors.lastname: van de Pol
authors.forename: A
authors.initials: A
authors.lastname: Hensel
authors.forename: F
authors.initials: F
authors.lastname: Barkhof
authors.forename: H J
authors.initials: HJ
authors.lastname: Gertz
authors.forename: P
authors.initials: P
authors.lastname: Scheltens
authors.forename: W M
authors.initials: WM
authors.lastname: van der Flier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease / Q000175:diagnosis*; D001284:Atrophy; D016022:Case-Control Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged