The role of vascular and hormonal genes in migraine susceptibility.
Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor but nonetheless significant impact on susceptibility. Migraine candidate gene studies have concentrated mainly on genes involved in neurotransmitter pathways, however evidence also exists for a role for alterations in vascular and hormonal function in migraine susceptibility. We present here a mini-review of genetic studies, investigating the potential role of vascular and hormonal gene variants, and discuss how vascular and hormonal dysfunction may impact on migraine susceptibility. We propose that the potential role of vascular and hormonal genes in this disorder warrants further investigation.
Colson
Natalie J
NJ
Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Qld 9726, Australia.
Lea
Rod A
RA
Quinlan
Sharon
S
Griffiths
Lyn R
LR
D001808:Blood Vessels / Q000503:physiopathology*; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006728:Hormones / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008881:Migraine Disorders / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics
D047628:Estrogen Receptor alpha; D006728:Hormones; D011980:Receptors, Progesterone; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D007703:Peptidyl-Dipeptidase A