title: Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization.
abstract: Here we report on early inflammatory events associated with Porphyromonas gingivalis-accelerated atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice. Animals challenged with P. gingivalis presented with increased macrophage infiltration, innate immune marker expression, and atheroma without elevated systemic inflammatory mediators. This early local inflammatory response was prevented in mice immunized with P. gingivalis. We conclude that localized up-regulation of innate immune markers early after infection, rather than systemic inflammation, contributes to pathogen-accelerated atherosclerosis.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Evans Biomedical Research Center, Room 637, 650 Albany St., Boston, MA 02118, USA.
authors.forename: Takanari
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yumoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Michael
authors.initials: M
authors.lastname: Davey
authors.forename: Frank C
authors.initials: FC
authors.lastname: Gibson
authors.forename: Caroline Attardo
authors.initials: CA
authors.lastname: Genco
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000276:immunology / Q000473:pathology; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D050197:Atherosclerosis / Q000382:microbiology* / Q000473:pathology / Q000517:prevention & control*; D016866:Bacteroidaceae Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D007113:Immunity, Innate; D007114:Immunization; D007249:Inflammation / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D008297:Male; D051379:Mice; D016966:Porphyromonas gingivalis / Q000276:immunology* / Q000472:pathogenicity; D013997:Time Factors
chemical_list: D001057:Apolipoproteins E