title: Chronic kidney disease following non-myeloablative hematopoietic cell transplantation.
abstract: Chronic kidney disease (CKD) following myeloablative allogeneic hematopoietic cell transplantation (HCT) occurs in 20% of survivors at 1 year and is believed to be due to radiation nephritis. Non-myeloablative allogeneic HCT is a recent procedure that employs significantly lower doses of chemoradiotherapy, however, incidence and risk factors for CKD following non-myleoablative HCT have not been defined. We performed a retrospective cohort study of 122 patients from three institutions who were available for analysis at 6 months following non-myeloablative HCT. Patients received two Gy of radiation; 62% received fludarabine as preconditioning. CKD was defined as at least a 25% reduction in glomerular filtration rate (GFR) from baseline using the abbreviated modified diet in renal disease (MDRD) equation. Eighty-one of 122 patients (66%) showed evidence of CKD at follow-up. Multivariate analysis revealed that acute renal failure (ARF) during the first 100 days post-transplant was associated with development of CKD (Adjusted OR 32.8 with 95% CI 4.3-250) after controlling for other variables. Previous autologous HCT, long-term calcineurin inhibitor use and extensive chronic GVHD were independently associated with CKD. CKD following non-myeloablative HCT appears to be a distinct clinical entity and likely not related to radiation nephritis. Future research should focus on possible mechanisms for alleviating chronic injury and decreasing use of calcineurin inhibitors.
authors.affiliation: University of Colorado Health Sciences Center, Denver, CO, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Weiss
authors.forename: B M
authors.initials: BM
authors.lastname: Sandmaier
authors.forename: B
authors.initials: B
authors.lastname: Storer
authors.forename: R
authors.initials: R
authors.lastname: Storb
authors.forename: P A
authors.initials: PA
authors.lastname: McSweeney
authors.forename: C R
authors.initials: CR
authors.lastname: Parikh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D065095:Calcineurin Inhibitors; D015331:Cohort Studies; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006977:Hypertension, Renal / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D007668:Kidney / Q000528:radiation effects; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008875:Middle Aged
chemical_list: D065095:Calcineurin Inhibitors