Apoptotic and proliferation indexes in primary superficial bladder tumors.
Whether apoptotic index [AI] and/or Ki-67 labeling index [Ki-67LI] add prognostic information in bladder cancer remains unclear. Mean AI and Ki-67 LI increased with grade and stage in 147 superficial bladder tumors. AI (>1.7%) correlated with tumor size, grade and proliferation. Ki-67 LI (>10%) correlated with higher grade and stage. Tumor size and Ki-67 LI were independent predictors of disease-free and progression-free survival, respectively. Tumor size, patient's age and tumor's recurrence predicted overall survival. We conclude that conventional clinical parameters and Ki-67 LI define risk groups of bladder tumors, while AI has limited value.
Gonzalez-Campora
Ricardo
R
Department of Pathology, Virgen Macarena University Hospital and University of Seville Medical School, Seville, Spain. rcampora@us.es
Davalos-Casanova
Guillermo
G
Beato-Moreno
Antonio
A
Luque
Rafael J
RJ
Alvarez-Kindelan
Jose
J
Requena
Maria J
MJ
Montironi
Rodolfo
R
Lopez-Beltrán
Antonio
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D049109:Cell Proliferation; D015331:Cohort Studies; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
D019394:Ki-67 Antigen