title: Angiotensin-converting enzyme genotype and adherence to aerobic exercise training.
abstract: Angiotensin-converting enzyme (ACE) has two common genetic variants: the insertion (I) and deletion (D) forms. ACE levels are greater in subjects with the D allele, and several studies suggest superior endurance performance in subjects with the I allele. The authors recently reported the results of a 6-month exercise training protocol examining the effect of apolipoprotein E on the lipid response. The present report examines the relationship of ACE genotype and exercise adherence. DNA samples were available for 110 subjects: 14 I/I, 52 I/D, and 44 D/D. Baseline and change in maximal oxygen uptake, body mass index, skinfold thickness, and serum lipids did not differ by ACE genotype, but adherence to exercise training was higher in I carriers than in D homozygotes. These preliminary results suggest that ACE genotype affects exercise adherence and raises the possibility that superior endurance capacity in subjects with the I allele is related to a genetic propensity to adhere to an exercise regimen.
authors.affiliation: Hartford Hospital, Hartford, CT 06102, USA. pthomps@harthosp.org
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Tsongalis
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ordovas
authors.forename: Richard L
authors.initials: RL
authors.lastname: Seip
authors.forename: Cherie
authors.initials: C
authors.lastname: Bilbie
authors.forename: Mary
authors.initials: M
authors.lastname: Miles
authors.forename: Robert
authors.initials: R
authors.lastname: Zoeller
authors.forename: Paul
authors.initials: P
authors.lastname: Visich
authors.forename: Paul
authors.initials: P
authors.lastname: Gordon
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Angelopoulos
authors.forename: Linda
authors.initials: L
authors.lastname: Pescatello
authors.forename: Niall
authors.initials: N
authors.lastname: Moyna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics; D015992:Body Mass Index; D015444:Exercise; D017079:Exercise Tolerance / Q000235:genetics; D005260:Female; D005838:Genotype; D006339:Heart Rate / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010806:Physical Education and Training
chemical_list: D001057:Apolipoproteins E; D007703:Peptidyl-Dipeptidase A