Differential glutamatergic modulation of monoamine release in the limbic lobe by selective anticonvulsant ionotropic and metabotropic glutamate receptor ligands.
Several researchers are currently trying to unravel neurobiological relationships between epilepsy and depression. After all, these disorders often develop in the same vulnerable brain regions and the importance of comorbid depression and epilepsy is still underscored. Facilitation of central serotonin (5-HT), dopamine (DA) and noradrenaline (NAD) release seems to be associated with both anticonvulsant and antidepressant effects. We show that selective ionotropic and metabotropic glutamate receptor ligands with anticonvulsant properties differentially modulate NAD, DA and 5-HT in rat limbic lobe structures.
Smolders
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Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information (FASC), Research Group Experimental Pharmacology (EFAR) Vrije Universiteit Brussel-Faculteit Geneeskunde, Brussels.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D002853:Chromatography, Liquid / Q000379:methods; D003863:Depression / Q000150:complications / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology*; D008024:Ligands; D008032:Limbic System / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008297:Male; D017551:Microdialysis / Q000379:methods; D009638:Norepinephrine / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000187:drug effects* / Q000378:metabolism; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D000927:Anticonvulsants; D000928:Antidepressive Agents; D008024:Ligands; D017470:Receptors, Glutamate; D018094:Receptors, Metabotropic Glutamate; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine