title: In vitro activity of sitafloxacin compared with several fluoroquinolones against Streptococcus anginosus and Streptococcus constellatus.
abstract: The in vitro activities of sitafloxacin and seven other fluoroquinolones a (ciprofloxacin, tosufloxacin, sparfloxacin, levofloxacin, T-3811ME, moxifloxacin and trovafloxacin) were examined by the microdilution method against 79 clinically isolated 'Streptococcus milleri' group (SMG) microorganisms. No statistically significant differences were found between the minimum inhibitory concentrations (MIC(50) and MIC(90)) against Streptococcus anginosus and Streptococcus constellatus. Sitafloxacin was the most active agent of the eight fluoroquinolones tested against SMG, with a MIC(90) of 0.06 microg/mL, which was 8 times more active than ciprofloxacin and 16 times more active than levofloxacin. Although none of the SMG strains showed high resistance to any of the fluoroquinolones tested, three agents (trovafloxacin, sitafloxacin and T-3811ME) had low MICs against 23 SMG strains against which levofloxacin had a MIC> 1 microg/mL. In conclusion, several fluoroquinolones have low MICs against SMG, but sitafloxacin has the lowest.
authors.affiliation: Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903-0125, Japan.
authors.forename: Natsuo
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujita
authors.forename: Takashi
authors.initials: T
authors.lastname: Shinzato
authors.forename: Futoshi
authors.initials: F
authors.lastname: Higa
authors.forename: Masao
authors.initials: M
authors.lastname: Tateyama
authors.forename: Masato
authors.initials: M
authors.lastname: Tohyama
authors.forename: Isamu
authors.initials: I
authors.lastname: Nakasone
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Yamane
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D034366:Streptococcus anginosus / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity; D034365:Streptococcus constellatus / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C076246:sitafloxacin