A tighter RVxF motif makes a finer Sift.
Most partners of protein phosphatase 1 rely on an instance of the so-called RVxF motif for interaction with the enzyme. In this issue of Chemistry & Biology, a stringent definition of the motif targeting high-affinity instances enabled Meiselbach and colleagues to recognize novel binding partners with high specificity .
Ceulemans
Hugo
H
Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Belgium.
Bollen
Mathieu
M
D020816:Amino Acid Motifs; D001665:Binding Sites; D010749:Phosphoprotein Phosphatases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D054645:Protein Phosphatase 1; D013379:Substrate Specificity
D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1