Variation in expression of gastric leptin according to differentiation and growth pattern in gastric adenocarcinoma.
Leptin is an adipocyte-derived hormone that regulates body fat stores and feeding behavior. The presence of leptin in stomach epithelium was recently demonstrated in the rat and humans, and gastric leptin has been linked to the control of meal size, local inflammatory responses, and paracrine and autocrine functions through leptin receptors in the stomach. We compared the expression patterns of leptin and of the long variant of the leptin receptor (Ob-Rb) between areas with non-ulcerated mucosa and with hyperplastic polyps, adenoma, or adenocarcinoma to evaluate the expression relative to different disease states. Leptin and Ob-Rb were expressed in hyperplastic polyps, adenoma, and adenocarcinoma. In the gastric adenocarcinoma, leptin was expressed significantly less in the poorly differentiated and diffuse-type groups than in the well-differentiated and moderately differentiated groups or in the intestinal type. Based upon our findings, we suggest the possibility that leptin expression can have a pathophysiologic role about the differentiation or growth pattern of gastric adenocarcinoma. A further series of experiments is necessary to elucidate the pathophysiological role of leptin in the differentiation of gastric adenocarcinoma.
Hong
Su Jin
SJ
Department of Gastroenterology, Institute for Digestive Research, Soon Chun Hyang University College of Medicine, 1174 Jung-dong, Wonmi-ku, Bucheon 420-853, South Korea.
Kwon
Kye Won
KW
Kim
Sang Gyune
SG
Ko
Bong Min
BM
Ryu
Chang Beom
CB
Kim
Young Seok
YS
Moon
Jong Ho
JH
Cho
Joo Young
JY
Lee
Joon Seong
JS
Lee
Moon Sung
MS
Shim
Chan Sup
CS
Kim
Boo Sung
BS
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000096:biosynthesis / Q000378:metabolism*; D008875:Middle Aged; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*
D020738:Leptin