Experience-dependent modification of mechanisms of long-term depression.
Mechanisms of long-term potentiation and depression (LTP and LTD) change considerably during development, but the importance of these changes and the factors that control them is not clear. We found that visual experience triggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recognition memory. Thus, changes in synaptic plasticity mechanisms were correlated with the changing physiological demands on the CNS.
Jo
Jihoon
J
Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
Ball
Simon M
SM
Seok
Heon
H
Oh
Seog Bae
SB
Massey
Peter V
PV
Molnar
Elek
E
Bashir
Zafar I
ZI
Cho
Kwangwook
K
D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism; D008027:Light; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009924:Organ Culture Techniques; D051381:Rats; D017470:Receptors, Glutamate / Q000096:biosynthesis; D011976:Receptors, Muscarinic / Q000096:biosynthesis; D014785:Vision, Ocular / Q000502:physiology
D017470:Receptors, Glutamate; D011976:Receptors, Muscarinic