title: Inhibition of pemphigus vulgaris by targeting of the CD40-CD154 co-stimulatory pathway: a step toward antigen-specific therapy?
abstract: The signaling of CD40 by its ligand, CD154, between T and B cells is required for humoral immune responses. Thus, blockade of this ligand-receptor interaction can prevent the development of antibody-mediated autoimmune diseases through different mechanisms.
authors.affiliation: Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. zhiliu@med.unc.edu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Luis A
authors.initials: LA
authors.lastname: Diaz
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology*; D006801:Humans; D010392:Pemphigus / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000906:Antibodies; D019013:CD40 Antigens; D023201:CD40 Ligand