title: Multiple tracheobronchial mucosal lesions in two cases of Churg-Strauss syndrome.
abstract: Churg-Strauss syndrome (CSS) is characterized by hypereosinophilia and a systemic necrotizing vasculitis seen almost exclusively in patients with asthma. The most common pathological findings in the chest in CSS are eosinophilic pneumonia, necrotizing vasculitis and granulomatous inflammation (extravascular granuloma). However, tracheobronchial mucosal lesions have rarely been reported in CSS. The authors report two patients with CSS who had multiple tracheobronchial mucosal lesions that were found by fibreoptic bronchoscopy. They were tiny nodular lesions and necrotizing bronchial inflammation with many eosinophils was observed upon pathological examination. The authors concluded that tracheobronchial mucosal lesions may be one of the manifestations of vasculitis seen in CSS.
authors.affiliation: Department of Internal Medicine, Saitama Red Cross Hospital, Japan. himatsushima@sunny.ocn.ne.jp
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Matsushima
authors.forename: Noboru
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kurashima
authors.forename: Daido
authors.initials: D
authors.lastname: Tokunaga
authors.forename: Mikio
authors.initials: M
authors.lastname: Ubukata
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kawabata
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
mesh_terms: D000328:Adult; D001980:Bronchi / Q000473:pathology*; D001999:Bronchoscopy; D015267:Churg-Strauss Syndrome / Q000473:pathology*; D005336:Fiber Optic Technology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020545:Respiratory Mucosa / Q000473:pathology*; D014132:Trachea / Q000473:pathology*