title: [Three patients with nephrotic syndrome due to membranous nephropathy complicated by Sjögren's syndrome].
abstract: We describe three females patients (age 40, 62 and 63 y) with nephrotic syndrome due to membranous nephropathy complicated by Sjögren's syndrome(SS). The patients satisfied the criteria for SS, but not those for systemic lupus erythematosus(SLE). All of them developed nephrotic syndrome, and light immunofluorescence as well as electron microscopy of renal biopsy specimens revealed membranous nephropathy. Two were positive for the SS-A antibody, and the other was positive for the SS-B antibody. Two were complicated with primary biliary cirrhosis (PBC) and autoimmune thyroiditis, whereas the other was complicated with interstitial pneumonia, but not with either PBC or autoimmune thyroiditis. Prednisolone (PSL) with or without cyclophosphamide improved the nephrotic syndrome in two of the patients. In conclusion, some patients with SS might become complicated with nephrotic syndrome due to membranous nephropathy if another systemic autoimmune disease exists.
authors.affiliation: First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Baba
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Hara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sato
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamada
authors.forename: Shouichi
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Tanenao
authors.initials: T
authors.lastname: Eto
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage; D012859:Sjogren's Syndrome / Q000150:complications*; D013967:Thyroiditis, Autoimmune / Q000150:complications
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone