Macrophages isolated from chickens genetically resistant or susceptible to systemic salmonellosis show magnitudinal and temporal differential expression of cytokines and chemokines following Salmonella enterica challenge.
Macrophages from inbred chickens that are resistant to salmonellosis show greater and more rapid expression of proinflammatory chemokines and cytokines, including the key Th1-inducing cytokine interleukin-18, upon Salmonella challenge than those from susceptible birds. This suggests the possibility that salmonellosis resistant-line macrophages signal more effectively and rapidly and are more able to induce protective Th1 adaptive responses.
Wigley
Paul
P
Department of Veterinary Pathology, University of Liverpool, Leahurst, Neston CH64 0SH, United Kingdom. Paul.Wigley@liverpool.ac.uk
Hulme
Scott
S
Rothwell
Lisa
L
Bumstead
Nat
N
Kaiser
Pete
P
Barrow
Paul
P
D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D002645:Chickens / Q000276:immunology / Q000382:microbiology*; D015169:Colony Count, Microbial; D016207:Cytokines / Q000378:metabolism*; D007113:Immunity, Innate; D008264:Macrophages / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D011201:Poultry Diseases / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D019779:Salmonella enterica / Q000276:immunology / Q000472:pathogenicity*; D012486:Salmonella typhimurium / Q000276:immunology / Q000472:pathogenicity*; D013047:Specific Pathogen-Free Organisms
D018925:Chemokines; D016207:Cytokines