title: Malignant hyperthermia following systemic rewarming after hypothermic cardiopulmonary bypass.
abstract: Malignant hyperthermia (MH) is a rare hypermetabolic disorder of skeletal muscle that can be fatal if not recognized and treated aggressively. We describe a patient with a suspected family history of MH who developed hyperpyrexia, acidosis, and hypermetabolism after cardiac surgery despite a nontriggering anesthetic. No drugs were identified as being causative and we theorize that systemic rewarming was the inciting cause of MH in this MH-susceptible individual via a mechanism similar to heat stroke.
authors.affiliation: Department of Anesthesiology, Weill-Cornell Medical Center, New York, New York, USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Lichtman
authors.forename: Charles
authors.initials: C
authors.lastname: Oribabor
mesh_terms: D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D011183:Postoperative Complications; D017694:Rewarming / Q000009:adverse effects*