Homocysteine and risk in end-stage renal disease: a matter of context.
Like blood pressure and cholesterol, homocysteine shows a paradoxical inverse relationship with cardiovascular complications in end-stage renal disease (ESRD). A paper by Ducloux et al. in this issue adds perhaps decisive evidence on malnutrition-hypoalbuminemia as the main factor explaining the counterintuitive association between homocysteine and clinical outcome reported in previous studies.
Zoccali
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Istituto di Biomedicina-Epidemiologia e Fisiopatologia Clinica delle Malattie Renali e dell'Ipertensione Arteriosa e Unità Operativa di Nefrologia, Dialisi e Trapianto Renale, Ospedali Riuniti, Reggio Calabria, Italy. carmine.zoccali@tin.it
Mallamaci
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D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D007249:Inflammation / Q000150:complications; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000401:mortality; D044342:Malnutrition / Q000150:complications; D012307:Risk Factors
D006710:Homocysteine