title: UPLC/MS for the identification of beta-blockers.
abstract: The beta-blockers Oxprenolol, Metoprolol, Acebutolol, Atenolol, Propranolol, Pindolol, and Alprenolol were analysed by both UPLC/MS and HPLC/MS using mobile phases containing acetonitrile, TFA and either H2O or D2O. UPLC gave superior separation performance and the quality of the mass spectra were at least as good as those from HPLC.
authors.affiliation: Analytical Development, PAR&D, AstraZeneca, Silk Business Park, Macclesfield, Cheshire SK10 2NA, UK. stephen.wren@astrazeneca.com
authors.forename: Stephen A C
authors.initials: SA
authors.lastname: Wren
authors.forename: Pierre
authors.initials: P
authors.lastname: Tchelitcheff
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003903:Deuterium; D004340:Drug Contamination; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods*; D008968:Molecular Conformation; D011786:Quality Control; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000319:Adrenergic beta-Antagonists; D007202:Indicators and Reagents; D012996:Solutions; D003903:Deuterium