Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis.
Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-gamma secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.
Cheong
Hee-Jin
HJ
Section of Infectious Disease, Department of Internal Medicine, Korea University Medical College, Korea University Guro Hospital, 97 Guro Dong-Gil, Guro Gu, Seoul 152-703, South Korea. heejinmd@medimail.co.kr
Song
Joon-Young
JY
Park
Jeong-Won
JW
Yeon
Jong-Eun
JE
Byun
Kwan-Soo
KS
Lee
Chang-Hong
CH
Cho
Hyun-Il
HI
Kim
Tai-Gyu
TG
Kim
Woo-Joo
WJ
D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis; D008103:Liver Cirrhosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014611:Vaccination
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D007371:Interferon-gamma