title: Influence of leisure-time physical activity on the relationship between C-reactive protein and hypertension in a community-based elderly population of Japan: the Tsurugaya project.
abstract: There are several studies indicating an association between C-reactive protein (CRP) and blood pressure (BP) in the Japanese population, but the influence of physical activity has not been considered. Therefore, we designed a cross-sectional survey to determine whether leisure-time physical activity (LTPA) modifies the relation between CRP and hypertension among Japanese elderly. Our study population comprised 643 subjects aged 70 years and over in whom CRP, home BP, and self-reported LTPA were measured. LPTA was categorized into three levels of intensity--walking, brisk walking, and sports-and a questionnaire was used to estimate the level in each patient. Hypertension was defined as a home systolic BP of 135 mmHg or over and/or home diastolic BP of 85 mmHg or over or current use of antihypertensive agents. LTPA levels were associated with both CRP and hypertension. After adjustment for factors affecting CRP and hypertension, and additional adjustment for LTPA levels, the odds ratio (95% confidence interval) of hypertension by CRP was 2.21 (range: 1.33-3.72), 1.99 (1.17-3.42), and 2.38 (1.36-4.21) times higher in subjects in the second, third, and fourth quartiles of CRP, as compared to subjects in the first quartile, respectively. A multiple regression model showed a positive and significant relation between log-transformed CRP and systolic BP after adjustment for potential confounding factors when participants taking antihypertensive medication were excluded. This is the first study to clarify that the positive significant relation between CRP and hypertension was independent of LTPA levels among Japanese elderly.
authors.affiliation: Department of Medicine and Science in Sports and Exercise, Tohoku University Graduate School of Medicine, Sendai, Japan. ggg@mail.tains.tohoku.ac.jp
authors.forename: Kaijun
authors.initials: K
authors.lastname: Niu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hozawa
authors.forename: Kazuki
authors.initials: K
authors.lastname: Fujita
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohmori
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Okutsu
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Nagatomi
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000209:etiology; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D009043:Motor Activity; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein