Antiinflammatory activity of Sambucus ebulus hexane extracts.
Hexane extracts of aerial parts (flowered browes), leaves and roots of Sambucus ebulus were investigated for their antiinflammatory activity in rats. Aerial parts and roots extracts produced statistically significant and dose dependent inhibition of edema induced by carrageenan at all doses when compared to the control groups. On the contrary, hexane extract of leaves did not show any activity up to 600 mg/kg i.p. The highest activity was showed in the aerial parts and roots that at 600 mg/kg i.p. inhibited inflammation by ca. 80% (78% for diclofenac at 100 mg /kg i.p.). No extracts exhibit toxicity when injected up to 2 g/ kg intraperitoneally in mice.
Ebrahimzadeh
M A
MA
Department of Medicinal Chemistry, School of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran. zadeh20@yahoo.com
Mahmoudi
M
M
Salimi
E
E
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006586:Hexanes / Q000737:chemistry; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027923:Sambucus / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D006586:Hexanes; D010936:Plant Extracts; D002351:Carrageenan