title: No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands.
abstract: Extra-nodal marginal zone B cell lymphomas (MZBCLs) of the mucosa-associated lymphoid tissues (MALT) arise at sites of chronic antigenic stimulation due to organ-specific autoimmunity or infections, like Helicobacter pylori-associated chronic gastritis and Borrelia burgdorferi dermatitis. Recently, conflicting data have been published regarding a possible association between Chlamydia psittaci and ocular adnexal MZBCL. In the present study, we analyzed a cohort of ocular adnexal MZBLs from the Netherlands for the presence of C. psittaci DNA. We found no evidence for the presence of C. psittaci DNA in any of the tumor samples studied. Our data do not support a role for C. psittaci in the pathogenesis of ocular adnexal lymphomas in patients from the Netherlands.
authors.affiliation: Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Marijn M S
authors.initials: MM
authors.lastname: Mulder
authors.forename: Edou R
authors.initials: ER
authors.lastname: Heddema
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Pannekoek
authors.forename: Koorosh
authors.initials: K
authors.lastname: Faridpooya
authors.forename: Monique E C M
authors.initials: ME
authors.lastname: Oud
authors.forename: Esther
authors.initials: E
authors.lastname: Schilder-Tol
authors.forename: Peerooz
authors.initials: P
authors.lastname: Saeed
authors.forename: Steven T
authors.initials: ST
authors.lastname: Pals
mesh_terms: D002690:Chlamydia Infections / Q000150:complications*; D002691:Chlamydophila psittaci; D015331:Cohort Studies; D005134:Eye Neoplasms / Q000453:epidemiology* / Q000382:microbiology; D016393:Lymphoma, B-Cell / Q000453:epidemiology* / Q000382:microbiology; D018294:Neoplasms, Adnexal and Skin Appendage / Q000453:epidemiology* / Q000382:microbiology; D009426:Netherlands / Q000453:epidemiology; D015203:Reproducibility of Results; D012189:Retrospective Studies