title: Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor.
abstract: Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A(2) and A(4) showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Yufang
authors.initials: Y
authors.lastname: Xu
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Jianwen
authors.initials: J
authors.lastname: Liu
authors.forename: Liyun
authors.initials: L
authors.lastname: Shen
authors.forename: Junhui
authors.initials: J
authors.lastname: Li
authors.forename: Yuanxing
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000073:Acenaphthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D014408:Biomarkers, Tumor; D015687:Cell Hypoxia / Q000187:drug effects*; D002478:Cells, Cultured / Q000187:drug effects; D006224:Cricetinae; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000494:pharmacology*; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism
chemical_list: D000073:Acenaphthenes; D014408:Biomarkers, Tumor; D003517:Cyclopentanes; D005456:Fluorescent Dyes; D009570:Nitriles; D010100:Oxygen