Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents.
Schiff base conjugates of p-aminosalicylic acid have been synthesized and characterized by elemental analysis, IR and (1)H NMR spectroscopy and cyclic voltammetry. Compounds containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher ClogP values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.
Patole
Jayendra
J
Department of Chemistry, University of Pune, Pune 411 007, India.
Shingnapurkar
Dipti
D
Padhye
Subhash
S
Ratledge
Colin
C
D010131:Aminosalicylic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009163:Mycobacterium bovis / Q000187:drug effects*; D020102:Mycobacterium smegmatis / Q000187:drug effects*; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D012545:Schiff Bases; D010131:Aminosalicylic Acid