title: Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer.
abstract: Near-infrared measurements of glucose in human plasma are performed using a custom, rapid, high-throughput filter-based spectrometer covering a spectral range between 2080 and 2315 nm. Quality of the measured glucose signals is quantified through the use of two figures of merit: selectivity and limit of detection. Selectivity measures the uniqueness of the glucose spectrum from among the interfering spectra. Limit of detection measures the smallest glucose concentration change detectable. The proposed system, which includes the spectroscopic hardware and a spectral preprocessing algorithm, is shown to produce a selectivity value of 0.57, with zero being nonselective and one being fully selective, and a limit of detection value of 2.2 mM. Prediction of an independent dataset is also performed using net analyte signal-based and partial least-squares multivariate calibration techniques, which produce standard error of prediction values of 1.14 and 1.45 mM, respectively.
authors.affiliation: Delta Search Labs, 400 Technology Square, Cambridge, Massachusetts 01239, USA. vidi@alum.mit.edu
authors.forename: Vidi
authors.initials: V
authors.lastname: Saptari
authors.forename: Kamal
authors.initials: K
authors.lastname: Youcef-Toumi
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods*
chemical_list: D001786:Blood Glucose