Novel strategies to identify relevant molecular signatures for complex human diseases based on data of identical-by-decent profiles and genomic context.
OBJECTIVE
To develop novel strategies to identify relevant molecular signatures for complex human diseases based on data of identical-by-decent profiles and genomic context.


METHODS
In the proposed strategies, we define four relevancy criteria for mapping SNP-phenotype relationships-point-wise IBD mean difference, averaged IBD difference for window, Z curve and averaged slope for window.


RESULTS
Application of these criteria and permutation test to 100 simulated replicates for two hypothetical American populations to extract the relevant SNPs for alcoholism based on sib-pair IBD profiles of pedigrees demonstrates that the proposed strategies have successfully identified most of the simulated true loci.


CONCLUSIONS
The data mining practice implies that IBD statistic and genomic context could be used as the informatics for locating the underlying genes for complex human diseases. Compared with the classical Haseman-Elston sib-pair regression method, the proposed strategies are more efficient for large-scale genomic mining.
Li
Chuan-xing
CX
Department of Bioinformatics, Harbin Medical University, Harbin 150086, China.
Du
Lei
L
Li
Xia
X
Gong
Bin-sheng
BS
Zhang
Jie
J
Rao
Shao-qi
SQ
D000437:Alcoholism / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods; D019295:Computational Biology; D008040:Genetic Linkage; D023281:Genomics / Q000379:methods*; D006801:Humans; D008957:Models, Genetic; D020412:Multifactorial Inheritance; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide