Subversion of actin dynamics by EPEC and EHEC.
During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC, respectively) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes. Much progress has been made recently in our understanding of how EPEC and EHEC regulate the pathways leading to local activation of two regulators of actin cytoskeleton dynamics, the Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex. A recent highlight is the unravelling of functions for effector proteins (particularly Tir, TccP, Map and EspG/EspG2) that are injected into the host cell by a type III secretion system.
Caron
Emmanuelle
E
Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.
Crepin
Valerie F
VF
Simpson
Nandi
N
Knutton
Stuart
S
Garmendia
Junkal
J
Frankel
Gad
G
D051376:Actin-Related Protein 2-3 Complex / Q000502:physiology; D000199:Actins / Q000502:physiology*; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D004926:Escherichia coli / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D037521:Virulence Factors / Q000502:physiology; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal / Q000502:physiology
D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D029968:Escherichia coli Proteins; C429282:EspG protein, E coli; C505458:EspG2 protein, E coli; D011956:Receptors, Cell Surface; C109287:Tir protein, E coli; D037521:Virulence Factors; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; C505370:tccP protein, E coli