title: Killed Candida albicans yeasts and hyphae inhibit gamma interferon release by murine natural killer cells.
abstract: Killed yeasts and hyphae of Candida albicans inhibit gamma interferon secretion by highly purified murine NK cells in response to the Toll-like receptor ligands lipopolysaccharide and zymosan. This effect, which is also observed in the presence of NK-activating cytokines (interleukin-2 [IL-2], IL-12, and IL-15), may represent a novel mechanism of immune evasion that contributes to the virulence of C. albicans.
authors.affiliation: Departamento de Microbiología y Ecología, Facultad de Ciencias Biológicas, Edificio de Investigación, C/ Dr. Moliner 50, 46100 Burjasot, Valencia, Spain.
authors.forename: Celia
authors.initials: C
authors.lastname: Murciano
authors.forename: Eva
authors.initials: E
authors.lastname: Villamón
authors.forename: José-Enrique
authors.initials: JE
authors.lastname: O'Connor
authors.forename: Daniel
authors.initials: D
authors.lastname: Gozalbo
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Gil
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D025301:Hyphae / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D007371:Interferon-gamma / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007378:Interleukins / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000235:genetics; D051197:Toll-Like Receptor 4 / Q000172:deficiency / Q000235:genetics; D015054:Zymosan / Q000276:immunology / Q000378:metabolism
chemical_list: D007378:Interleukins; D008070:Lipopolysaccharides; C493486:Tlr2 protein, mouse; C493487:Tlr4 protein, mouse; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D007371:Interferon-gamma; D015054:Zymosan