SERPINA3 polymorphism is not associated with primary intracerebral hemorrhage in a Polish population.
OBJECTIVE
Genetic factors involved in the pathogenesis of primary intracerebral hemorrhage (PICH) remain unknown. One of the candidate genes is SERPINA3. Results of a Spanish study suggested that TT genotype of the A/T SERPINA3 polymorphism in the signal peptide sequence was a risk factor for PICH in normotensive subjects. The aim of the present study was to investigate whether SERPINA3 A/T polymorphism is associated with PICH in a Polish population.


METHODS
We analyzed 95 PICH patients and 190 unrelated healthy controls matched for age and sex. A/T polymorphism of the SERPINA3 gene was investigated using polymerase chain reaction restriction fragment length polymorphism method.


RESULTS
The distribution of SERPINA3 genotypes was similar among PICH patients (AA 27.4%; AT 46.3%; TT 26.3%) and controls (AA 23.7%; AT 50.5%; TT 25.8%; P=NS). There were also no significant differences in genotype distribution when analyzing separately hypertensive and normotensive PICH patients as well as patients with lobar and deeply located hemorrhage.


CONCLUSIONS
We failed to find an association between SERPINA3 A/T polymorphism and PICH in a Polish population.
Pera
Joanna
J
Department of Neurology, Jagiellonian University, Krakow, Poland. pera@su.krakow.pl
Slowik
Agnieszka
A
Dziedzic
Tomasz
T
Szczudlik
Andrzej
A
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006470:Hemorrhage; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012044:Regression Analysis; D012306:Risk; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
D000514:alpha 1-Antichymotrypsin