title: [Young women with atypical endometrial hyperplasia or endometrial adenocarcinoma stage I: will conservative treatment allow pregnancy? Results of a French multicentric survey].
abstract: OBJECTIVE
  To analyse the carcinological and obstetrical results of young women with atypical endometrial hyperplasia or endometrial adenocarcinoma, treated in a conservative way to allow pregnancy.
  
  
  METHODS
  A retrospective analysis of 13 cases (5 adenocarcinomas and 8 atypical hyperplasias) followed in 8 French centers between 1997 and 2004.
  
  
  RESULTS
  After 4.6 months of conservative treatment, there were no residual lesions in 61.5% of the cases. Progestatives seem to be the most effective treatment. Tumoral regression makes it possible to plan a pregnancy, with childbirth in 25% of the cases. In these frequently infertile patients, all the techniques of assisted reproduction can be used. Recurrences are not rare after hormonal treatment (37.5%), so, total hysterectomy is justified after delivery.
  
  
  CONCLUSIONS
  Conservative treatment for young women with atypical endometrial hyperplasia or endometrial adenocarcinoma stage I can be considered in some cases to enable pregnancy.
authors.affiliation: Service de gynécologie-obstétrique, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France. jfledigabel@chu-angers.fr
authors.forename: J-F
authors.initials: JF
authors.lastname: Le Digabel
authors.forename: C
authors.initials: C
authors.lastname: Gariel
authors.forename: L
authors.initials: L
authors.lastname: Catala
authors.forename: C
authors.initials: C
authors.lastname: Dhainaut
authors.forename: P
authors.initials: P
authors.lastname: Madelenat
authors.forename: P
authors.initials: P
authors.lastname: Descamps
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D004714:Endometrial Hyperplasia / Q000188:drug therapy* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007246:Infertility / Q000209:etiology* / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D011256:Pregnancy Outcome; D011372:Progestins / Q000627:therapeutic use; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies
chemical_list: D011372:Progestins