Synthesis of reduced xanthatin derivatives and in vitro evaluation of their antifungal activity.
Abstract The synthesis of new xanthanolide derivatives is reported starting from xanthatin, a sesquiterpenic lactone isolated from Xanthium macrocarpum (Asteraceae). In vitro evaluation of their antifungal activity has been investigated.
Pinel
Benoit
B
EA 921, Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, 49100 Angers, France.
Landreau
Anne
A
Seraphin
Denis
D
Larcher
Gerald
G
Bouchara
Jean-Philippe
JP
Richomme
Pascal
P
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D031210:Xanthium / Q000737:chemistry
D000935:Antifungal Agents; D005663:Furans; C022186:xanthatin