Targeted drug delivery for refractory hemorrhagic Crohn disease.
Focal gastrointestinal inflammation and hemorrhage is a common problem associated with Crohn disease. The present report describes a case of chronic hemorrhage from an inflamed duodenum that was refractory to all endoscopic and systemic therapies, which was successfully treated with chemoembolization of the pancreaticoduodenal arcade with use of corticosteroids and gelatin sponge. The application of chemoembolization techniques need not be limited to treatment of malignancies.
Sze
Daniel Y
DY
Division of Cardiovascular/Interventional Radiology, H-3646, Stanford University Medical Center, Stanford, California 94305-5642, USA. dansze@stanford.edu
D001158:Arteries / Q000473:pathology; D016461:Chemoembolization, Therapeutic; D003424:Crohn Disease / Q000150:complications* / Q000601:surgery; D003907:Dexamethasone / Q000627:therapeutic use*; D004382:Duodenitis / Q000209:etiology / Q000628:therapy; D004386:Duodenum / Q000098:blood supply; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy*; D005781:Gelatin Sponge, Absorbable; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005938:Glucocorticoids; D003907:Dexamethasone