title: Challenges facing the biologist doing chemical genetics.
abstract: The goal of high-throughput screening (HTS) from the perspective of the biologist is to identify a highly specific small molecule that can be used to inhibit a protein in its normal biological context. Although several useful small molecules have been identified with HTS, there are many challenges to be considered when contemplating a screen, especially by those unfamiliar with chemical biology.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA. jfs@berkeley.edu
authors.forename: Jon
authors.initials: J
authors.lastname: Soderholm
authors.forename: Mike
authors.initials: M
authors.lastname: Uehara-Bingen
authors.forename: Karsten
authors.initials: K
authors.lastname: Weis
authors.forename: Rebecca
authors.initials: R
authors.lastname: Heald
mesh_terms: D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D019295:Computational Biology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D008967:Molecular Biology; D012984:Software