title: Soluble adhesion molecules ICAM-1, VCAM-1, P-selectin in children with Helicobacter pylori infection.
abstract: OBJECTIVE
  To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children with Helicobacter pylori (H pylori) infection and to evaluate their significance for the morphological changes found in gastric mucosa.
  
  
  METHODS
  The study included 106 children: 59 children (55.7%) with chronic gastritis and positive IgG against H pylori, 29 children (27.3%) after previous H pylori infection without the bacterium colonization but with positive IgG against H pylori, and 18 children (17%) with functional disorders of the gastrointestinal system but with normal IgG against H pylori. Endoscopic and histopathological evaluation of gastric mucosa was performed based on the Sydney System classification. The evaluation of sP-selectin, sICAM-1, sVCAM-1 levels in the sera of children was carried out using ELISA test.
  
  
  RESULTS
  The assessment of gastritis activity degrees indicated statistically significant values in the antrum and corpus (P<0.001) of children examined. Serum sVCAM-1 levels were higher in group with gastritis due to H pylori infection than in group without infection and differed statistically (P<0.05). Serum sVCAM-1 levels proved to be the highest among other adhesive molecules in infected children and decreased after eradication of H pylori. Serum sICAM-1 levels were similar in all examined groups. Serum sP-selectin levels were similar in children with and without H pylori infection.
  
  
  CONCLUSIONS
  Assessment of adhesive molecules (sP-selectin, sICAM-1, sVCAM-1) in the sera of children with active H pylori infection can show the participation of sVCAM-1 in the pathogenesis of gastric mucosal inflammation. sP-selectin and sICAM-1 concentrations in the sera of children with H pylori infection after eradication cannot reveal any significant differences as compared to healthy children.
authors.affiliation: Department of Pediatric Nursing, Medical University of Bialystok, Waszyngtona Str., 15, 15-274 Bialystok, Poland. emaciorkowska@o2.pl
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Maciorkowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Kaczmarski
authors.forename: Anatol
authors.initials: A
authors.lastname: Panasiuk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kondej-Muszynska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kemonai
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D005756:Gastritis / Q000097:blood / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood* / Q000175:diagnosis; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D019007:P-Selectin / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013270:Stomach / Q000033:anatomy & histology / Q000382:microbiology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1