title: The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning.
abstract: Tob (transducer of ErbB-2) is a negative cell cycle regulator with anti-proliferative activity in peripheral tissues. Our previous study identified Tob as a protein involved in hippocampus-dependent memory consolidation (M.L. Jin, X.M. Wang, Y.Y. Tu, X.H. Zhang, X. Gao, N. Guo, Z.Q. Xie, G.P. Zhao, N.H. Jing, B.M. Li, Y.Yu, The negative cell cycle regulator, Tob (Transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory, Neuroscience 131 (2005) 647-659). Here, we provide evidence that Tob in the central nervous system is engaged in acquisition of motor skill. Tob has a relatively high expression in the cerebellum. Tob expression is up-regulated in the cerebellum after rats receive training on a rotarod-running task. Rats infused with Tob antisense oligonucleotides into the 4th ventricle exhibit a severe deficit in running on a rotating rod or walking across a horizontally elevated beam.
authors.affiliation: Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han-Dan Road, Shanghai 200433, China.
authors.forename: Xin-Ming
authors.initials: XM
authors.lastname: Wang
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Xue-Han
authors.initials: XH
authors.lastname: Zhang
authors.forename: Yan-Yang
authors.initials: YY
authors.lastname: Tu
authors.forename: Mei-Lei
authors.initials: ML
authors.lastname: Jin
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Nai-He
authors.initials: NH
authors.lastname: Jing
authors.forename: Bao-Ming
authors.initials: BM
authors.lastname: Li
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism*; D005246:Feedback / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012097:Repressor Proteins / Q000378:metabolism*; D045442:Rotarod Performance Test; D013647:Task Performance and Analysis; D014018:Tissue Distribution
chemical_list: D018797:Cell Cycle Proteins; D012097:Repressor Proteins; C508773:Tob1 protein, rat