title: Preliminary study on treatment of partial androgen deficiency in aging males with Jingui Shenqi Pill.
abstract: OBJECTIVE
  To observe the efficacy and safety of Jingui Shengqi Pill in treating partial androgen deficiency in aging males (PADAM), and to explore the new approach in improving the quality of life in PADAM patients.
  
  
  METHODS
  Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function (IIEF) scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen (PSA), etc., and the data before treatment were compared with those after treatment in the same group.
  
  
  RESULTS
  After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85 +/- 0.36 before treatment and 5.02 +/- 0.83 after treatment (P < 0.05); luteinizing hormone of 7.33 +/- 2.14 and 4.84 +/- 1.43 (P < 0.01), follicle-stimulating hormone of 10.22 +/- 4.48 and 6.47 +/- 3.28 (P < 0.01), respectively. The level of PSA failed to change significantly (1.94 +/- 0.55 and 2.06 +/- 0.47, P > 0.05).
  
  
  CONCLUSIONS
  JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.
authors.affiliation: The First Hospital of Changzhou City, 3rd Affiliated Hospital of Suzhou University, Jiangsu 213003. erya_guo@hotmail.com
authors.forename: Wen-jun
authors.initials: WJ
authors.lastname: Che
authors.forename: Xiao-zhou
authors.initials: XZ
authors.lastname: He
authors.forename: Jian-pin
authors.initials: JP
authors.lastname: Jiang
authors.forename: Wen-yuan
authors.initials: WY
authors.lastname: Cai
authors.forename: Si-jie
authors.initials: SJ
authors.lastname: Xie
mesh_terms: D000368:Aged; D000728:Androgens / Q000172:deficiency*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000188:drug therapy; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D013739:Testosterone / Q000097:blood
chemical_list: D000728:Androgens; D004365:Drugs, Chinese Herbal; C510025:jingui shenqi; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017430:Prostate-Specific Antigen