Temporary diabetes mellitus secondary to a primary pancreatic Burkitt lymphoma.
Primary pancreatic lymphoma (PPL) is a rare form of extranodal lymphoma. So far, only in adults has a coincidence with diabetes mellitus (DM) been described. We report a nearly 9-year-old German boy presenting with a Burkitt lymphoma associated with a temporary insulin-dependent DM and exocrine insufficiency of the pancreas. After the patient went into remission, a spontaneous recovery of the endocrine pancreatic function was observed. On immunophenotyping, the lymphoma cells revealed expression of FasL suggesting a potentially apoptotic effect on pancreatic tissue. Beta cell impairment may have been caused by FasL resembling autoimmune diabetes.
Meier
Constance
C
Hospital for Children and Adolescents, University of Leipzig Medical Center, Leipzig, Germany.
Kapellen
Thomas
T
Tröbs
Ralph B
RB
Hirsch
Wolfgang
W
Parwaresch
Reto
R
Kiess
Wieland
W
Körholz
Dieter
D
D002051:Burkitt Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000209:etiology*; D053222:Fas Ligand Protein; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012075:Remission, Spontaneous; D048069:Tumor Necrosis Factors / Q000378:metabolism
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D048069:Tumor Necrosis Factors