title: Mouse models for the genetic study of tuberculosis susceptibility.
abstract: Tuberculosis, mainly caused by the pathogenic bacterium Mycobacterium tuberculosis, remains an inestimable public health problem, despite the established use of the Bacillus Calmette-Guerin (BCG) vaccine, multidrug therapy and the existence of global tuberculosis control programmes. Statistics show that nearly 2 billion people (approximately one-third of the world's population) are infected with M. tuberculosis. For unknown reasons, only about 10 per cent of those infected by M. tuberculosis will develop tuberculosis, resulting in 9 million new cases yearly and 2 million deaths. A better understanding of the host--mycobacterial--environmental interplay is central to developing better antituberculosis vaccines and treatments. This review will discuss how a clearer idea of this interplay is emerging with new genomic strategies in mouse models.
authors.affiliation: McGill University Health Centre Research Institute, 1650 Cedar Ave, L11-520, Montreal, PQ, H3G 1A4, Canada.
authors.forename: Tania
authors.initials: T
authors.lastname: Di Pietrantonio
authors.forename: Erwin
authors.initials: E
authors.lastname: Schurr
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease; D007371:Interferon-gamma / Q000378:metabolism; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D010641:Phenotype; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D014376:Tuberculosis / Q000235:genetics*; D032581:Tuberculosis Vaccines
chemical_list: D001500:BCG Vaccine; D032581:Tuberculosis Vaccines; D007371:Interferon-gamma