title: Erdheim-Chester's disease of the heart: a diagnostic conundrum and collision with the same mass in the orbit.
abstract: Erdheim-Chester's disease is a rare multisystem xanthogranulomatosis, afflicting the skeletal system with the occasional involvement of soft tissues. We delineate an unusual case of a cardiac variant of Erdheim-Chester's disease presenting with pericardial effusion and as a collision with a synchronous orbital manifestation. We describe our diagnostic pathway and propose a novel treatment option involving nonsteroidal anti-inflammatory drugs. The role of cyclo-oxygenase in the disease process and inhibition thereof by NSAIDs is hypothesized and discussed.
authors.affiliation: Division of Cardiac Surgery, Center for Cardiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Bogáts
authors.forename: Györgyi
authors.initials: G
authors.lastname: Piros
authors.forename: László
authors.initials: L
authors.lastname: Tiszlavicz
authors.forename: Béla
authors.initials: B
authors.lastname: Iványi
authors.forename: Viktor
authors.initials: V
authors.lastname: Sasi
authors.forename: László
authors.initials: L
authors.lastname: Csepregil
authors.forename: Judit
authors.initials: J
authors.lastname: Simon
authors.forename: Barna
authors.initials: B
authors.lastname: Babik
authors.forename: Andrea
authors.initials: A
authors.lastname: Csillik
authors.forename: Lilla
authors.initials: L
authors.lastname: Kardos
authors.forename: András
authors.initials: A
authors.lastname: Palkó
authors.forename: Keyvan
authors.initials: K
authors.lastname: Matin
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Hanzély
authors.forename: Katalin
authors.initials: K
authors.lastname: Korányi
authors.forename: István
authors.initials: I
authors.lastname: Nyáry
authors.forename: Mihály
authors.initials: M
authors.lastname: Végh
authors.forename: Lajos
authors.initials: L
authors.lastname: Kolozsvári
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Kahán
authors.forename: András
authors.initials: A
authors.lastname: Bajcsay
authors.forename: Attila
authors.initials: A
authors.lastname: Tóth
authors.forename: György
authors.initials: G
authors.lastname: Balázs
authors.forename: Tamás
authors.initials: T
authors.lastname: Simor
authors.forename: László
authors.initials: L
authors.lastname: Pávics
authors.forename: András
authors.initials: A
authors.lastname: Palotás
mesh_terms: D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D031249:Erdheim-Chester Disease / Q000175:diagnosis / Q000188:drug therapy*; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy*; D011720:Pyrazoles / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib