Postrenal transplant non-EBV multiple myeloma of donor origin.
Multiple myeloma occurring after solid organ transplantation is a rare condition, with only a few case reports found in the literature. We report a case of Epstein-Barr virus-negative, posttransplant multiple myeloma in a 67-year-old female, presenting 18 months after renal transplantation. Interestingly, fluorescence in situ hybridization analysis of the tumor revealed a Y chromosome in the majority of the cells, indicating that the neoplasm was derived from the donor kidney. To our knowledge, this represents the first reported case with these features.
Peri
N
N
Department of Radiology, University of Washington Medical Center, Seattle, Washington, USA.
Kussick
S
S
Bakthavatsalam
R
R
Mitsumori
L
L
Dighe
M
M
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D041322:Chromosomes, Human, Y; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology; D009101:Multiple Myeloma / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D011183:Postoperative Complications / Q000175:diagnosis* / Q000473:pathology; D014019:Tissue Donors