title: [Effect of birth cohort, period of diagnosis and age on cancer incidence in Navarra, 1973-1997].
abstract: BACKGROUND
  Population-based registers are one source of information about cancer incidence. Systematic study of its incidence in a specific population is a fundamental tool for estimating the present-day and future magnitude of cancer and provides elements for taking decisions with regard to the allocation of health resources. The aim of this article was to investigate the time trend in the incidence pattern of cancer in Navarre during the period 1973-1997, and to identify the components of age, diagnosis period and birth cohort as determinants of the time trend of cancer incidence.
  
  
  METHODS
  Descriptive study of cancer incidence through age-period-cohort models. Monitoring of dynamic cohort over 25 years. Classical incidence summarizing indicators were analysed. Log-linear Poisson models were developed to quantify cancer risk and the relative annual trend. Age-period-cohort models were adjusted in order to ascertain the effect on the time trend exerted by the respective age, diagnosis period and birth cohort components.
  
  
  RESULTS
  The age-standardized rate incidence for all sites -except non melanoma skin tumours- is maximum in the five-year period 1993-1997, in men: 304,1 new cases per 100,000 person-years, and in women: 190,6 new cases per 100,000 person-years. The average incidence changes for each of the 25 years of monitoring of the set data studied is 1.88% (95% CI 1.69 to 2.07) in men and 1.32% (95% CI 1.09 to 1.54) in women. The cancer increase in women is more pronounced from 35 to 64 years, a fact which should alert health authorities about the future evolution of cancer incidence in women. In the analysis of the trend components sharp increases are observed for the consecutive generations of males born in Navarre since 1900. In women, the risk associated with the year of birth increases markedly in the generations born after 1930-1940.
  
  
  CONCLUSIONS
  There was an important increase in cancer incidence in Navarre from 1973 to 1997, in men and women. The cancer incidence pattern in Navarre does not yet show signs of stabilization.
authors.affiliation: Servicio de Docencia Investigación y Desarrollo Sanitarios, Departamento de Salud, Pamplona, 31008, Spain. riesgo.vascular@cfnavarra
authors.forename: P
authors.initials: P
authors.lastname: González Diego
authors.forename: M T
authors.initials: MT
authors.lastname: Jiménez Buñuales
authors.forename: J J
authors.initials: JJ
authors.lastname: Viñes
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology; D013997:Time Factors