title: Comorbidity profile of dementia patients in primary care: are they sicker?
abstract: OBJECTIVE
  To compare the medical comorbidity of older patients with and without dementia in primary care.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Wishard Health Services, which includes a university-affiliated, urban public hospital and seven community-based primary care practice centers in Indianapolis.
  
  
  METHODS
  Three thousand thirteen patients aged 65 and older attending seven primary care centers in Indianapolis, Indiana.
  
  
  METHODS
  An expert panel diagnosed dementia using International Classification of Diseases, 10th Revision, criteria. Comorbidity was assessed using 10 physician-diagnosed chronic comorbid conditions and the Chronic Disease Score (CDS).
  
  
  RESULTS
  Patients with dementia attending primary care have on average 2.4 chronic conditions and receive 5.1 medications. Approximately 50% of dementia patients in this setting are exposed to at least one anticholinergic medication, and 20% are prescribed at least one psychotropic medication. After adjusting for patients' age, race, and sex, patients with and without dementia have a similar level of comorbidity (mean number of chronic medical conditions, 2.4 vs 2.3, P=.66; average CDS, 5.8 vs 6.2, P=.83).
  
  
  CONCLUSIONS
  Multiple medical comorbid conditions are common in older adults with and without dementia in primary care. Despite their cholinergic deficit, a substantial proportion of patients with dementia are exposed to anticholinergic medications. Models of care that incorporate this medical complexity are needed to improve the treatment of dementia in primary care.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Cathy C
authors.initials: CC
authors.lastname: Schubert
authors.forename: Malaz
authors.initials: M
authors.lastname: Boustani
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Callahan
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Perkins
authors.forename: Caroline P
authors.initials: CP
authors.lastname: Carney
authors.forename: Christopher
authors.initials: C
authors.lastname: Fox
authors.forename: Frederick
authors.initials: F
authors.lastname: Unverzagt
authors.forename: Siu
authors.initials: S
authors.lastname: Hui
authors.forename: Hugh C
authors.initials: HC
authors.lastname: Hendrie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D002908:Chronic Disease / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D019338:Polypharmacy; D011320:Primary Health Care
chemical_list: D018680:Cholinergic Antagonists