Efficacy of Citrus reticulata and Mirazid in treatment of Schistosoma mansoni.
This work has been carried out to investigate the effect of Schistosoma mansoni infection on mice livers after treatment with the ethanolic extract of Citrus reticulata root or the oleo-resin extract from Myrrh of Commiphora molmol tree (Mirazid), as a new antishistosomal drug. Marker enzymes for different cell organelles were measured; succinate dehydrogenase (SDH); lactate dehydrogenase (LDH) and its isoenzymes; glucose-6-phosphatase (G-6-Pase); acid phosphatase (AP) and 5'- nucleotidase. Liver function enzymes; aspartate aminotransferase (AST); alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were also estimated. Parasitological studies through ova count and worm burden will also be taken into consideration. The results showed a marked reduction in SDH, LDH, AST, and ALT enzyme activities and a significant increase in G-6-Pase, AP, 5'- nucleotidase, and ALP after S. mansoni infection. A noticeable alteration in LDH subunits were also noticed. Treatment with C. reticulata or Mirazid improved all the previous enzyme activities with a noticeable reduction in ova count and worm burden.
Hamed
Manal A
MA
Department of Medicinal Chemistry, National Research Centre, Dokki, Cairo, Egypt. manal_hamed@yahoo.com
Hetta
Mona H
MH
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002957:Citrus; D029744:Commiphora; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000201:enzymology / Q000469:parasitology; D008297:Male; D051379:Mice; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000201:enzymology; D012556:Schistosomicides / Q000627:therapeutic use*; D013729:Terpenes / Q000627:therapeutic use*
D015415:Biomarkers; D010936:Plant Extracts; D012556:Schistosomicides; D013729:Terpenes; C014119:myrrh oil