Yersinia's stratagem: targeting innate and adaptive immune defense.
In contrast to Salmonella and Shigella, enteropathogenic Yersinia species are extracellular multiplying Gram-negative bacteria. This life style requires a sophisticated anti-host strategy, which is implemented by the Yersinia virulence plasmid. This plasmid encodes the type 3 secretion system (injectisome), at least six microinjected anti-host effector proteins, a trimeric coiled coil outer membrane protein (Yersinia adhesin) with cell adhesin and protective functions against complement and defensins, and the released V antigen, which has Toll-like receptor 2 agonist activity.
Heesemann
Jürgen
J
Max von Pettenkofer-Institut, Pettenkoferstrasse 9 a, D-80336 Muenchen, Germany. Heesemann@m3401.mpk.med.uni-muenchen.de
Sing
Andreas
A
Trülzsch
Konrad
K
D018829:Adhesins, Bacterial / Q000502:physiology; D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D003165:Complement System Proteins / Q000276:immunology; D023082:Defensins / Q000037:antagonists & inhibitors; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D010957:Plasmids; D021381:Protein Transport; D051195:Toll-Like Receptor 2 / Q000819:agonists; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*; D015007:Yersinia / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D015009:Yersinia Infections / Q000276:immunology / Q000382:microbiology*
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D023082:Defensins; D051195:Toll-Like Receptor 2; D037521:Virulence Factors; C064832:YadA protein, Yersinia; D003165:Complement System Proteins