title: A case of Darier's disease successfully treated with topical tacrolimus.
abstract: Tacrolimus is a macrolide that inhibits T-cell activation. The most extensive experience with topical tacrolimus has been in treating atopic dermatitis but it has been used in various skin diseases, including Hailey-Hailey disease, with encouraging results. We report a case of extensive Darier's disease successfully treated with topical tacrolimus, after suspension of oral isotretrinoin due to major depression.
authors.affiliation: Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy. rubegni@unisi.it
authors.forename: P
authors.initials: P
authors.lastname: Rubegni
authors.forename: S
authors.initials: S
authors.lastname: Poggiali
authors.forename: P
authors.initials: P
authors.lastname: Sbano
authors.forename: M
authors.initials: M
authors.lastname: Risulo
authors.forename: M
authors.initials: M
authors.lastname: Fimiani
mesh_terms: D000287:Administration, Topical; D000328:Adult; D007644:Darier Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus