Fly Src: the Yin and Yang of tumor invasion and tumor suppression.
The non-receptor tyrosine kinase Src is inactivated by the C-terminal Src kinase Csk. In a recent paper in Developmental Cell, Vidal et al. show that loss of Drosophila Csk (dCsk) in a large field of cells results in cell proliferation and disorganization of tissue architecture. In contrast, local inactivation of dCsk in a small field of cells results in loss of cells that are adjacent to normal tissue. This loss occurs by basal migration and death by apoptosis. These findings may shed light on mechanisms that restrain tumor initiation.
Martin
G Steven
GS
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, 16 Barker Hall #3204, Berkeley, California 94720, USA. gsm@berkeley.edu
D000818:Animals; D017209:Apoptosis; D019521:Body Patterning; D002465:Cell Movement; D004330:Drosophila / Q000378:metabolism / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004789:Enzyme Activation; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D009154:Mutation; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology*; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000235:genetics / Q000502:physiology; D019061:src-Family Kinases / Q000235:genetics / Q000502:physiology*
D029721:Drosophila Proteins; D051417:Focal Adhesion Kinase 1; D016392:Proto-Oncogene Proteins pp60(c-src); D019061:src-Family Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D020778:Matrix Metalloproteinase 2