title: Synthesis and screening of bicyclic carbohydrate-based compounds: a novel type of antivirals.
abstract: A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure-activity relationship for this new type of antivirals is discussed.
authors.affiliation: Laboratory for Organic and Bioorganic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 (S.4), B-9000 Ghent, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Van Hoof
authors.forename: Bart
authors.initials: B
authors.lastname: Ruttens
authors.forename: Idzi
authors.initials: I
authors.lastname: Hubrecht
authors.forename: Gert
authors.initials: G
authors.lastname: Smans
authors.forename: Petra
authors.initials: P
authors.lastname: Blom
authors.forename: Benedikt
authors.initials: B
authors.lastname: Sas
authors.forename: Johan
authors.initials: J
authors.lastname: Van hemel
authors.forename: Jan
authors.initials: J
authors.lastname: Vandenkerckhove
authors.forename: Johan
authors.initials: J
authors.lastname: Van der Eycken
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D003587:Cytomegalovirus / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000196:embryology / Q000821:virology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D002241:Carbohydrates