Chiari I malformation and idiopathic growth hormone deficiency in siblings.
BACKGROUND
The authors report a case of three brothers. Two of these siblings presented with congenital growth hormone deficiency and Chiari I malformation. The third and younger brother has been found not to have growth hormone deficiency or the Chiari I malformation.


RESULTS
Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa has been determined to be altered in patients with Chiari I malformation and growth hormone deficiency.


CONCLUSIONS
Our current case reports strengthen the association between these two pathological entities and are, to our knowledge, the first description of both defects in siblings.
Murphy
R L
RL
School of Medicine, University of Alabama, Birmingham, AL 35233, USA.
Tubbs
R S
RS
Grabb
P A
PA
Oakes
W J
WJ
D001139:Arnold-Chiari Malformation / Q000150:complications* / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D035781:Siblings; D013116:Spinal Cord / Q000473:pathology / Q000601:surgery
D010743:Phospholipids; C009371:syringomyelin; D013006:Growth Hormone