Protein sensors for membrane sterols.
Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
Goldstein
Joseph L
JL
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. joe.goldstein@utsouthwestern.edu
DeBose-Boyd
Russell A
RA
Brown
Michael S
MS
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D008954:Models, Biological; D013261:Sterols / Q000737:chemistry / Q000378:metabolism*
D008565:Membrane Proteins; D013261:Sterols