title: Duloxetine treatment for women awaiting continence surgery.
abstract: The study assessed the effect of offering a 4-week course of duloxetine therapy to 73 women awaiting a tension-free vaginal tape (TVT) operation. Twenty-seven women (37%) declined taking the drug, leaving 46 women (63%) willing to take drug therapy. Thirteen women were scheduled for a TVT with concurrent prolapse surgery, and 1 of these women decided that she no longer needed the surgery. Eight of the 33(24%) women scheduled for a TVT without concurrent prolapse surgery came off the waiting list. Nine women of the 33 women scheduled for a TVT without concurrent surgery (27%) found that the medication did not work sufficiently well. Sixteen of the 33 women (48%) discontinued medication due to side-effects. Women on a waiting list for surgery may be unwilling to take duloxetine therapy and less tolerant of side-effects.
authors.affiliation: Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Gillingham, Kent, ME7 5NY, UK. jraduckett@hotmail.com
authors.forename: J R A
authors.initials: JR
authors.lastname: Duckett
authors.forename: I
authors.initials: I
authors.lastname: Aggarwal
authors.forename: A
authors.initials: A
authors.lastname: Patil
mesh_terms: D003131:Combined Modality Therapy; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D019736:Prostheses and Implants; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*; D014550:Urinary Incontinence, Stress / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery; D014596:Uterine Prolapse / Q000453:epidemiology; D014850:Waiting Lists
chemical_list: D000068736:Duloxetine Hydrochloride; D017367:Selective Serotonin Reuptake Inhibitors; D013876:Thiophenes