title: Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide.
abstract: Two novel series of 4-thiazolidinone derivatives, namely 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid [2-(5-nitro-2-furyl/substituted phenyl)-4-thiazolidinone-3-yl]amides (5a-g) and 2-(2',4'-difluoro-4-hydroxybiphenyl-3-carbonylhydrazono)-3-alkyl/aryl-4-thiazolidinones (6a-e) together with 5-(2',4'-difluoro-4-hydroxybiphenyl-5-yl)-2-cyclohexylamino-1,3,4-oxadiazole (7a) have been synthesized as title compounds. 1-(2',4'-Difluoro-4-hydroxybiphenyl-3-carbonyl)-4-alkyl/arylthiosemicarbazides (4a-g) were also obtained and used as intermediate to give the title compounds. All synthesized compounds were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv, antiviral and antimicrobial activities against various virus, bacteria and fungi strains.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul, Turkey. gkucukguzel@marmara.edu.tr
authors.forename: Güniz
authors.initials: G
authors.lastname: Küçükgüzel
authors.forename: Ayla
authors.initials: A
authors.lastname: Kocatepe
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Fikrettin
authors.initials: F
authors.lastname: Sahin
authors.forename: Medine
authors.initials: M
authors.lastname: Güllüce
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D004061:Diflunisal / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure; D012663:Semicarbazides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D006834:Hydrazines; D012663:Semicarbazides; D013844:Thiazoles; D004061:Diflunisal