title: Factors influencing nerve regeneration in a trial of timcodar dimesylate.
abstract: The authors assessed the ability of the neurophilin compound, timcodar dimesylate, to accelerate the return of epidermal nerve fiber density (ENFD) after a standardized nerve injury in a randomized double blind, placebo controlled trial. While there was no difference in the regeneration rate between the treatment and placebo arms, the baseline ENFD (p = 0.006), height (p = 0.02), and race (p = 0.03) were associated with the regeneration rate.
authors.affiliation: Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA. mpolyde@jhmi.edu
authors.forename: M
authors.initials: M
authors.lastname: Polydefkis
authors.forename: M
authors.initials: M
authors.lastname: Sirdofsky
authors.forename: P
authors.initials: P
authors.lastname: Hauer
authors.forename: B G
authors.initials: BG
authors.lastname: Petty
authors.forename: B
authors.initials: B
authors.lastname: Murinson
authors.forename: J C
authors.initials: JC
authors.lastname: McArthur
mesh_terms: D000328:Adult; D001706:Biopsy; D004311:Double-Blind Method; D004817:Epidermis / Q000294:innervation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009416:Nerve Regeneration / Q000187:drug effects*; D017288:Pain Threshold; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology; D011725:Pyridines / Q000627:therapeutic use*; D012684:Sensory Thresholds; D013848:Thigh; D014110:Touch; D014947:Wounds and Injuries / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology
chemical_list: D011725:Pyridines; C494139:timcodar