title: Cyclodextrin-based isolation of Ostwald's metastable polymorphs occurring during crystallization.
abstract: We describe a novel approach for the selective isolation of Ostwald's intermediate metastable polymorphs occurring during an early stage of crystallization, by utilizing the inclusion complex formed with a cyclic oligosaccharide derivative, 2,6-di-O-methyl-beta-cyclodextrin.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. uekama@gpo.kumamoto-u.ac.jp
authors.forename: Yoh
authors.initials: Y
authors.lastname: Sonoda
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Hirayama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Arima
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Wolfram
authors.initials: W
authors.lastname: Saenger
authors.forename: Kaneto
authors.initials: K
authors.lastname: Uekama
mesh_terms: D003460:Crystallization; D003505:Cyclodextrins / Q000737:chemistry*; D015394:Molecular Structure; D013997:Time Factors; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D047392:beta-Cyclodextrins