title: Epitheliotropic cutaneous lymphoma (mycosis fungoides) in a dog.
abstract: A seven-year-old castrated male Yorkshire terrier dog was presented for a recurrent skin disease. Erythematous skin during the first visit progressed from multiple plaques to patch lesions and exudative erosion in the oral mucosa membrane. Biopsy samples were taken from erythematous skin and were diagnosed with epitheliotropic T cell cutaneous lymphoma by histopathology and immunochemical stain. In serum chemistry, the dog had a hypercalcemia (15.7 mg/dl) and mild increased alkaline phosphatase (417 U/l). Immunohistochemistry was performed to detect parathyroid hormone-related peptide (PTH-rP) in epitheliotropic cutaneous lymphoma tissues but the neoplastic cells were not labeled with anti-PTH-rP antibodies. The patient was treated with prednisolone and isotretinoin. However, the dog died unexpectedly.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors.forename: Dong Ha
authors.initials: DH
authors.lastname: Bhang
authors.forename: Ul Soo
authors.initials: US
authors.lastname: Choi
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Eun-Hwa
authors.initials: EH
authors.lastname: Choi
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kang
authors.forename: Cheol-Yong
authors.initials: CY
authors.lastname: Hwang
authors.forename: Dae-Yong
authors.initials: DY
authors.lastname: Kim
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Youn
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Lee
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D015474:Isotretinoin / Q000627:therapeutic use; D008297:Male; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D011239:Prednisolone; D015474:Isotretinoin