title: Synthesis of reduced xanthatin derivatives and in vitro evaluation of their antifungal activity.
abstract: Abstract The synthesis of new xanthanolide derivatives is reported starting from xanthatin, a sesquiterpenic lactone isolated from Xanthium macrocarpum (Asteraceae). In vitro evaluation of their antifungal activity has been investigated.
authors.affiliation: EA 921, Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, 49100 Angers, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Pinel
authors.forename: Anne
authors.initials: A
authors.lastname: Landreau
authors.forename: Denis
authors.initials: D
authors.lastname: Seraphin
authors.forename: Gerald
authors.initials: G
authors.lastname: Larcher
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouchara
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D031210:Xanthium / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D005663:Furans; C022186:xanthatin