RARRES1 expression is significantly related to tumour differentiation and staging in colorectal adenocarcinoma.
Retinoic acid receptor responder 1 (RARRES1) is a retinoid regulated gene. Its expression is frequently down-regulated through DNA hypermethylation in several types of malignant tissues. This study investigated the clinical significance of RARRES1 protein and its association with RARRES3 protein expression in 161 (26 adenoma, 13 distal normal mucosa and 122 primary colorectal adenocarcinoma) paraffin-embedded colorectal tissues by immunohistochemistry. RARRES1 protein was detected at the highest levels in terminally differentiated cells of normal mucosal tissues and all 26 adenoma tissues. Among 122 colorectal adenocarcinomas, the poorly differentiated adenocarcinomas and Dukes' stage D tumours showed a significant decrease in RARRES1 expression (P < 0.001 and P < 0.01, respectively). RARRES1 expression was significantly (P < 0.001) correlated with RARRES3 expression, which was positively associated with tumour differentiation (P < 0.001). Difference in expression of RARRES1 among 119 patients had no apparent effect on patient survival. Our results suggest the role of RARRES1 in colorectal epithelial differentiation, and the down-regulation of RARRES1 is related to stage D progression.
Wu
Chang-Chieh
CC
Graduate Institutes of Medical Sciences, National Defense Medical Center, 161 Minchuan East Road, Sec. 6, Taipei 114, Taiwan, ROC.
Shyu
Rong-Yaun
RY
Chou
Jung-Mao
JM
Jao
Shu-Wen
SW
Chao
Pei-Chieh
PC
Kang
Jung-Cheng
JC
Wu
Sheng-Tang
ST
Huang
Shiang-Long
SL
Jiang
Shun-Yuan
SY
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D016019:Survival Analysis
D008565:Membrane Proteins; C437968:PLAAT4 protein, human; C452562:RARRES1 protein, human; D018168:Receptors, Retinoic Acid