title: Effectiveness of abbreviated and delayed 7-valent pneumococcal conjugate vaccine dosing regimens.
abstract: We estimated the effectiveness of abbreviated regimens of 7-valent pneumococcal conjugate vaccine (PCV7) based on serotyped cases of invasive pneumococcal disease (IPD) in children under 5 reported from 2001 to 2004 to two US surveillance programs. Vaccination regimens included in the analysis were 1 dose < 3 months old, 2 doses < 5 months old, 3 doses < 7 months old, full schedule (3 doses and a booster), 1 dose at 12-23 months, and 2 doses at 12-23 months. Vaccine effectiveness (VE) was calculated as (1-Mantel-Haenszel summary odds ratio in vaccinated children, as compared to unvaccinated children)x100% for each regimen, stratifying by year. Among 400 eligible cases, for vaccine-type IPD, VE was 90.5% for the full schedule, 76.6% for 3 doses < 7 months old, and 70.5% for 2 doses < 5 months old; 1 dose < 3 months provided no significant protection. No regimen provided significant protection against vaccine-related serotypes. Data for regimens begun at 12-23 months were inconclusive. These data support the use of the 2-dose and 3-dose infant PCV7 regimens when the full series cannot be delivered and detail the limitations of abbreviated dosing regimens.
authors.affiliation: Departments of Epidemiology and Pediatrics, T3E, Boston University School of Public Health and Medicine, 715 Albany Street, Boston, MA 02118, USA. mahonbe@bu.edu
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Mahon
authors.forename: Katherine
authors.initials: K
authors.lastname: Hsu
authors.forename: Sudharani
authors.initials: S
authors.lastname: Karumuri
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Kaplan
authors.forename: Edward O
authors.initials: EO
authors.lastname: Mason
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Pelton
mesh_terms: D002675:Child, Preschool; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D018074:Vaccines, Conjugate / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate