title: Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge.
abstract: The possible reemergence of smallpox through bioterrorism requires the preparation of adequate stockpiles of vaccine. Dryvax, the only US-licensed vaccinia virus smallpox vaccine, has an unacceptable safety profile in the pre-event setting. LC16m8 is a Japanese-licensed attenuated vaccinia virus strain that has been safely used in over 50,000 persons. Until now, efficacy of this vaccine was unproven. Using two animal models, we show that LC16m8 and Dryvax elicit comparable humoral immune responses after a single vaccination and equivalently protect against lethal poxvirus disease. Thus, LC16m8 shows promise as a safe and effective smallpox vaccine with the potential for replacing Dryvax.
authors.affiliation: VaxGen Inc., 347 Oyster Point Boulevard, Suite 102, South San Francisco, CA 94080, USA. cempig@vaxgen.com
authors.forename: Cyril
authors.initials: C
authors.lastname: Empig
authors.forename: Julie R
authors.initials: JR
authors.lastname: Kenner
authors.forename: Marcel
authors.initials: M
authors.lastname: Perret-Gentil
authors.forename: Bryan E
authors.initials: BE
authors.lastname: Youree
authors.forename: Edward
authors.initials: E
authors.lastname: Bell
authors.forename: Allen
authors.initials: A
authors.lastname: Chen
authors.forename: Marc
authors.initials: M
authors.lastname: Gurwith
authors.forename: Keith
authors.initials: K
authors.lastname: Higgins
authors.forename: Michael
authors.initials: M
authors.lastname: Lock
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Rice
authors.forename: Jill
authors.initials: J
authors.lastname: Schriewer
authors.forename: Faruk
authors.initials: F
authors.lastname: Sinangil
authors.forename: Elizabeth
authors.initials: E
authors.lastname: White
authors.forename: R Mark
authors.initials: RM
authors.lastname: Buller
authors.forename: Terence S
authors.initials: TS
authors.lastname: Dermody
authors.forename: Stuart N
authors.initials: SN
authors.lastname: Isaacs
authors.forename: Richard W
authors.initials: RW
authors.lastname: Moyer
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002460:Cell Line; D005260:Female; D051379:Mice; D018155:Orthopoxvirus; D011213:Poxviridae Infections / Q000517:prevention & control*; D011817:Rabbits; D012900:Smallpox Vaccine / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D012900:Smallpox Vaccine; D014613:Vaccines, Attenuated