title: [Molecular pathogenesis in monogenic and polygenic obesity].
abstract: During the last few years, studies of the molecular pathogenesis of obesity both in mouse models and in the rare cases of monogenic obesity in humans have added significantly to our understanding of the key role of the hypothalamus in mediating hunger and satiety. These insights have brought us closer to the development of rational therapies of obesity, the epidemic of which is continuing in the post-industrial society, which is characterised by sedentary behaviour patterns.
authors.affiliation: Steno Diabetes Center, DK-2820 Gentofte. oluf@steno.dk.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Larsen
authors.forename: Søren M
authors.initials: SM
authors.lastname: Echwald
authors.forename: Thorkild I A
authors.initials: TI
authors.lastname: Sørensen
authors.forename: Oluf Borbye
authors.initials: OB
authors.lastname: Pedersen
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology; D051379:Mice; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000378:metabolism; D054411:Receptors, Leptin; D012527:Satiation / Q000502:physiology
chemical_list: D011956:Receptors, Cell Surface; D054411:Receptors, Leptin