Structural and functional properties of genes involved in human cancer.
BACKGROUND
One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer.


RESULTS
We have conducted an analysis of a set of genes known to be involved in cancer in order to unveil their unique features that can assist towards the identification of new candidate cancer genes.


CONCLUSIONS
We have detected key patterns in this group of genes in terms of the molecular function or the biological process in which they are involved as well as sequence properties. Based on these features we have developed an accurate Bayesian classification model with which human genes have been scored for their likelihood of involvement in cancer.
Furney
Simon J
SJ
Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK. simon.furney@ucd.ie
Higgins
Desmond G
DG
Ouzounis
Christos A
CA
López-Bigas
Núria
N
D000595:Amino Acid Sequence; D000818:Animals; D001499:Bayes Theorem; D017124:Conserved Sequence; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011506:Proteins / Q000737:chemistry / Q000235:genetics
D009363:Neoplasm Proteins; D011506:Proteins