Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome.
BACKGROUND
Polycystic ovary syndrome (PCOS) is associated with menstrual and reproductive abnormalities, insulin resistance, and obesity.


OBJECTIVE
The objective of this study was to determine the prevalence of diagnosed PCOS and its association with cardiovascular risk factors.


METHODS
The study is set in an integrated health care delivery system in northern California.


METHODS
A total of 11,035 women with PCOS were identified by one or more outpatient diagnoses of PCOS using health plan databases. An age-matched sample of women without PCOS was also selected.


METHODS
Prevalence of PCOS and targeted cardiovascular risk factors [hypertension, dyslipidemia, diabetes mellitus, and body mass index (BMI)] were measured.


RESULTS
During 2002-2004, the prevalence of diagnosed PCOS among female members aged 25-34 yr was 2.6% (95% confidence interval 1.6-1.7%). Women with diagnosed PCOS were more likely than those without PCOS to be obese [BMI > or = 30 mg/m(2); odds ratio (OR) 4.21, 3.96-4.47]. Furthermore, PCOS was associated with diabetes (OR 2.45, confidence interval 2.16-2.79), hypertension (OR 1.41, 1.31-1.51) and known dyslipidemia (OR 1.53, 1.39-1.68), even after adjusting for BMI and known confounders. Among women with PCOS, compared with whites, Blacks and Hispanics were more likely and Asians less likely to be obese; Asians and Hispanics were more likely to have diabetes; and Blacks were more likely and Hispanics less likely to have hypertension.


CONCLUSIONS
Within a large, community-based population receiving health care, diagnosed PCOS was highly prevalent and associated with a much higher frequency of cardiovascular risk factors that varied by race/ethnicity. Our prevalence estimates likely underestimate the true prevalence of PCOS. Further studies are needed to explore racial/ethnic differences and the extent to which PCOS contributes to future cardiovascular risk.
Lo
Joan C
JC
Division of Research, Kaiser Permanente of Northern California, 2000 Broadway Street, 2nd Floor, Oakland, CA 94612-2304, USA. Joan.C.Lo@kp.org
Feigenbaum
Seth L
SL
Yang
Jingrong
J
Pressman
Alice R
AR
Selby
Joe V
JV
Go
Alan S
AS
D000328:Adult; D015992:Body Mass Index; D002140:California / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D016208:Databases, Factual; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology*; D018570:Risk Assessment