title: Rate constants for anilidyl radical cyclization reactions.
abstract: [reaction: see text] N-Aryl-5,5-diphenyl-4-pentenamidyl radicals (3) were produced by 266 nm laser-flash photolysis of the corresponding N-(phenylthio) derivatives, and the rate constants for the cyclizations of these radicals were measured directly. The 5-exo cyclization reactions were fast (k(c) > 2 x 10(5) s(-1)), and radicals 3 generally behaved as electrophilic reactants with a Hammett correlation of rho = 1.9 for five of the six radicals studied. However, the p-methoxyphenyl-substituted radical 3f cyclized much faster than expected from the Hammett analysis. Variable temperature studies of parent radical 3a (aryl = phenyl) gave an Arrhenius function with log k = 9.2 - 4.4/2.3RT (kcal/mol). The rate constant for the reaction of p-ethylphenyl-substituted anilidyl radical 3b with Bu(3)SnH at 65 degrees C was k(T) = 4 x 10(5) M(-1) s(-1).
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.
authors.forename: E
authors.initials: E
authors.lastname: Martinez
authors.forename: M
authors.initials: M
authors.lastname: Newcomb
mesh_terms: D000813:Anilides / Q000737:chemistry*; D007700:Kinetics; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D013416:Sulfamerazine / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000813:Anilides; D007769:Lactams; C471392:sulfenamide; D013416:Sulfamerazine