title: [The effect of erythropoetin on doxorubicin-induced oxidative stress in rat kidney].
abstract: The early nephrotoxicity manifestations (oxidative stress) caused by a single administration of doxorubicin in rats and the therapeutic effect of erythropoietin have been studied. The introduction of doxorubicin leads to a decrease in the concentration of glutathione and the activity of glutathione reductase in rat kidneys, which is indicative of the development of oxidative stress. Erythropoietin restores glutathione content on the normal level. The pretreatment with erythropoietin reduces the doxorubicin induced damage in rat kidneys.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Saenko
authors.forename: A M
authors.initials: AM
authors.lastname: Shutov
authors.forename: S M
authors.initials: SM
authors.lastname: Napalkova
authors.forename: O S
authors.initials: OS
authors.lastname: Selivanova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Evstegneeva
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004921:Erythropoietin / Q000008:administration & dosage*; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000293:injuries / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats
chemical_list: D000903:Antibiotics, Antineoplastic; D004921:Erythropoietin; D004317:Doxorubicin; D005978:Glutathione