title: Cladobotric acids A-F: new cytotoxic polyketides from a New Zealand Cladobotryum sp.
abstract: [reaction: see text] Cladobotric acids A-F (1-6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1-6 was concluded from feeding experiments with (13)C-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A-F (1-6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans.
authors.affiliation: Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8020, New Zealand.
authors.forename: Maya I
authors.initials: MI
authors.lastname: Mitova
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: John W
authors.initials: JW
authors.lastname: Blunt
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Cummings
authors.forename: Anthony L J
authors.initials: AL
authors.lastname: Cole
authors.forename: Ward T
authors.initials: WT
authors.lastname: Robinson
authors.forename: Murray H G
authors.initials: MH
authors.lastname: Munro
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020171:Botrytis / Q000737:chemistry* / Q000302:isolation & purification; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009520:New Zealand
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents