title: Polygalacturonase inhibiting proteins: players in plant innate immunity?
abstract: Polygalacturonase-inhibiting proteins (PGIPs) are extracellular leucine-rich repeat (LRR) proteins that recognize and inhibit fungal polygalacturonases (PGs). The PG-PGIP interaction favours the accumulation of elicitor-active oligogalacturonides and causes the activation of defence responses. Small gene families encode PGIP isoforms that differ in affinity and specificity for PGs secreted by different pathogens. The consensus motif within the LRR structure of PGIPs is the same as that of the extracellular receptors of the plant innate immune system. Structural and functional evidence suggest that PGIPs are versatile proteins involved in innate immunity and that they are capable of recognizing different surface motifs of functionally related but structurally variable PGs.
authors.affiliation: Ce.S.I. Centro Studi sull'Invecchiamento and Dipartimento di Scienze Biomediche. Universita' di Chieti "G. D'Annunzio". Via dei Vestini 31, 66013 Chieti, Italy. lfederici@unich.it
authors.forename: Luca
authors.initials: L
authors.lastname: Federici
authors.forename: Adele
authors.initials: A
authors.lastname: Di Matteo
authors.forename: Juan
authors.initials: J
authors.lastname: Fernandez-Recio
authors.forename: Demetrius
authors.initials: D
authors.lastname: Tsernoglou
authors.forename: Felice
authors.initials: F
authors.lastname: Cervone
mesh_terms: D005075:Biological Evolution; D004791:Enzyme Inhibitors / Q000276:immunology*; D005656:Fungal Proteins / Q000276:immunology; D005658:Fungi / Q000201:enzymology; D010935:Plant Diseases; D010940:Plant Proteins / Q000276:immunology*; D010944:Plants / Q000276:immunology*; D011096:Polygalacturonase / Q000037:antagonists & inhibitors* / Q000276:immunology; D011487:Protein Conformation; D020449:Repetitive Sequences, Amino Acid
chemical_list: D004791:Enzyme Inhibitors; D005656:Fungal Proteins; C081479:PGIP protein, plant; D010940:Plant Proteins; D011096:Polygalacturonase