[Anxiodepressive and neuromediatory disorders in hypertensive patients. Effects of cypramil therapy].
OBJECTIVE
To investigate psychic status and characteristics of neuromediatory metabolism in hypertensive patients, efficacy of antihypertensive therapy with lisinopril and hydrochlorthiaside with adjuvant citalopram (cipramil) which is a selective inhibitor of serotonin reuptake.


METHODS
Fifty patients with hypertension stage II (37 females, 13 males, mean age 48 years, mean duration of the disease 10.6 years) have undergone psychometric examination, estimation of evoked potentials P-300, 24-h monitoring of blood pressure. Plasma levels of epinephrine and norepinephrine, plasma and platelet levels of serotonin and 5-OIAA were measured at high-performance liquid chromatography.


RESULTS
Hypertensive patients were found to have high levels of depression, reactive and personality anxiety, subnormal quality of life. Blood pressure lowered more in patients given adjuvant cipramil.


CONCLUSIONS
Hypertensive patients have anxiodepressive disorders accompanied by monoamines disbolism. Cipramil effectively corrects these disorders.
Nedostup
A V
AV
Fedorova
V I
VI
Linevich
A Iu
AIu
Pukhal'skaia
T G
TG
Toropina
G G
GG
Kudrin
V S
VS
Klodt
P M
PM
D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001007:Anxiety / Q000150:complications / Q000188:drug therapy*; D015283:Citalopram / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000031:analogs & derivatives / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D017706:Lisinopril / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D000959:Antihypertensive Agents; D015283:Citalopram; D006852:Hydrochlorothiazide; D017706:Lisinopril; D018377:Neurotransmitter Agents; D017367:Selective Serotonin Reuptake Inhibitors; C009732:buthiazide