[Study on treatment effectiveness and safety in children with chronic hepatitis B or C using bicyclo tablets].
BACKGROUND
To evaluate treatment effectiveness and safety of bicyclo tablets in children with chronic hepatitis B or C.


METHODS
A randomized controlled trial was conducted in 148 children with chronic hepatitis B or C for evaluating safety, tolerability, and efficacy of treatment with bicyclo tablets or Hugan tablets. Children in therapy group were treated with bicyclo tablets and control group treated with Hugan tablets.


RESULTS
(1) ALT and AST level decreased more prominently in therapy group than in control group (P<0.01). (2) Bicyclo was more effective than Hugan tablets (P<0.01). (3) Symptoms were ameliorated more prominently in bicyclo group than in control group (P<0.01). (4) Both groups had no significant adverse events.


CONCLUSIONS
Satisfactory therapeutic effect and safety were obtained with bicyclo tablets in children with chronic hepatitis B or C.
Zhang
Hong-fei
HF
Department of Pediatric Liver Disease, The No. 302 Hospital of The People's Liberation Army, Beijing 100039, China.
Yang
Xiao-jin
XJ
Zhu
Shi-shu
SS
Xu
Zhi-qiang
ZQ
Dong
Yi
Y
Chen
Da-wei
DW
Jia
Wen-zheng
WZ
Gan
Yu
Y
Wang
Li-min
LM
Tang
Hong-mei
HM
D000293:Adolescent; D001713:Biphenyl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D013607:Tablets; D016896:Treatment Outcome
D001713:Biphenyl Compounds; D013607:Tablets; C477843:bicyclol