4-Chloro-2,2-disubstituted chromen-3-carboxaldehyde: synthesis of some fused polycyclic heterocycles as anti-inflammatory, analgesic, anticonvulsant, and antiparkinsonian agents.
Some new aldazino 4, pyrazolo 5, thieno 8, and thiooxopyrimidino chromenes 10 were prepared via reaction of the corresponding beta-chlorocarboxaldehyde 3 with hydrazine hydrate, mercaptoacetic acid, and thiourea, respectively. Wherever, 4-chlorochromene derivatives 2 along with 4-chlorochromen-3-carboxaldehyde derivatives 3 were prepared from the corresponding ketone 1 with Vilsmeier-Haack reagent. Some of the new products showed good anti-inflammatory, analgesic, anticonvulsant, and antiparkinsonian activities comparable to indomethacin, diclofenace, carbamazepine, and benztropine.
Hegab
Mohamed I
MI
Photochemistry Department, National Research Centre, Giza, Cairo, Egypt. mihegab65@yahoo.com
Abdulla
Mohamed M
MM
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D000978:Antiparkinson Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D015232:Dinoprostone / Q000378:metabolism; D004487:Edema / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010095:Oxotremorine; D010146:Pain / Q000517:prevention & control; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013997:Time Factors; D015016:Yohimbine
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000978:Antiparkinson Agents; D001578:Benzopyrans; D006571:Heterocyclic Compounds; D015016:Yohimbine; D010095:Oxotremorine; D002351:Carrageenan; D015232:Dinoprostone