Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients.
Dengue virus infection can cause mild dengue fever (DF) or severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Cytokines are believed to be involved in the pathogenesis of dengue infection. However, the role of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) in dengue infection is unclear. In this study, serum levels of MIF in adult dengue patients with different disease severity and clinical outcome were determined and compared with the levels of other cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10, and interferon gamma (IFN-gamma), in the same patients. Serum levels of MIF, IL-6, and IL-10, but not IFN-gamma or TNF-alpha, were higher in all DHF patients who died than in DHF survivors and DF patients. We conclude that in addition to IL-6 and IL-10, elevated levels of serum MIF are a potential predictor of disease severity and clinical outcome in dengue patients.
Chen
Lien-Cheng
LC
Institute of Basic Medical Sciences, Department of Microbiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lei
Huan-Yao
HY
Liu
Ching-Chuan
CC
Shiesh
Shu-Chu
SC
Chen
Shun-Hua
SH
Liu
Hsiao-Sheng
HS
Lin
Yee-Shin
YS
Wang
Shan-Tair
ST
Shyu
Huey-Wen
HW
Yeh
Trai-Ming
TM
D000328:Adult; D000368:Aged; D002648:Child; D003715:Dengue / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D008263:Macrophage Migration-Inhibitory Factors; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma