title: Mid-infrared spectroscopy on skin using a silver halide fibre probe in vivo.
abstract: OBJECTIVE
  Mid-infrared spectroscopy is a versatile method for in vivo investigation of skin after topical treatment with skin care products.
  
  
  METHODS
  FTIR-spectrometer (Bruker Optics) with a flexible silver halide fibre probe (Infrared Fiber Sensors).
  
  
  RESULTS
  Absorbance spectra from 700 to 3000 cm(-1) have been recorded to gain information about proteins (amide-I and amide-II vibrations at 1650 and 1550 cm(-1)), esters (1740 cm(-1)), carboxylic acid (1710 cm(-1)), polyalcohols (1050 cm(-1)) and hydrocarbons (CH(n) vibrations at 2800-3000 cm(-1)).
  
  
  CONCLUSIONS
  Using the particular light guide, we were able to measure for the first time the effects of lip care products on lips directly. Furthermore, water binding and glycerol content of the skin could be determined simultaneously, as well as the replenishment of lipids by lipid-enriched bath oil.
authors.affiliation: Department of Research and Development, Beiersdorf AG, Hamburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ring
authors.forename: V
authors.initials: V
authors.lastname: Schreiner
authors.forename: H
authors.initials: H
authors.lastname: Wenck
authors.forename: K P
authors.initials: KP
authors.lastname: Wittern
authors.forename: L
authors.initials: L
authors.lastname: Küpper
authors.forename: R
authors.initials: R
authors.lastname: Keyhani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003358:Cosmetics / Q000008:administration & dosage; D046169:Dermoscopy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012834:Silver; D012867:Skin / Q000737:chemistry* / Q000187:drug effects; D017592:Skin Care / Q000379:methods; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods; D014867:Water / Q000032:analysis*
chemical_list: D003358:Cosmetics; D008055:Lipids; D014867:Water; D012834:Silver