title: Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment.
abstract: Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD.
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. dabcns@uky.edu
authors.forename: D Allan
authors.initials: DA
authors.lastname: Butterfield
authors.forename: Tanea
authors.initials: T
authors.lastname: Reed
authors.forename: Marzia
authors.initials: M
authors.lastname: Perluigi
authors.forename: Carlo
authors.initials: C
authors.lastname: De Marco
authors.forename: Raffaella
authors.initials: R
authors.lastname: Coccia
authors.forename: Chiara
authors.initials: C
authors.lastname: Cini
authors.forename: Rukhsana
authors.initials: R
authors.lastname: Sultana
mesh_terms: D000369:Aged, 80 and over; D000447:Aldehydes / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism*; D003072:Cognition Disorders / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D010296:Parietal Lobe / Q000378:metabolism; D011485:Protein Binding
chemical_list: D000447:Aldehydes; C027576:4-hydroxy-2-nonenal