The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysis.
BACKGROUND
No clear consensus has been reached yet on how best to characterize children who suffer from pediatric bipolar disorder (PBD). The CBCL-PBD profile on the Child Behavior Checklist (CBCL) has been consistently reported showing deviant findings on the Attention Problems, Aggressive Behavior, and Anxious-Depressed subscales.


OBJECTIVE
To examine the sensitivity and specificity of the proposed CBCL-PBD profile for determining DSM diagnosis of PBD.


METHODS
We applied receiver operating characteristic (ROC) curve analysis to data from 471 probands from two family studies of attention-deficit hyperactivity disorder and their 410 siblings.


RESULTS
The CBCL-PBD score demonstrated an area under the curve (AUC) of 0.97 for probands and 0.82 for siblings for current diagnosis of PBD, suggesting that the CBCL-PBD provided a highly efficient way of identifying subjects with a current diagnosis of PBD in this sample.


CONCLUSIONS
These findings suggest that the CBCL-PBD may provide a highly efficient way of screening for childhood bipolar disorder.
Faraone
Stephen V
SV
Medical Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA. faraones@upstate.edu
Althoff
Robert R
RR
Hudziak
James J
JJ
Monuteaux
Michael
M
Biederman
Joseph
J
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D001714:Bipolar Disorder / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D002648:Child; D002653:Child Behavior Disorders / Q000150:complications / Q000175:diagnosis*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005192:Family Health; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D010552:Personality Assessment; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D035781:Siblings