[Molecular pathogenesis in monogenic and polygenic obesity].
During the last few years, studies of the molecular pathogenesis of obesity both in mouse models and in the rare cases of monogenic obesity in humans have added significantly to our understanding of the key role of the hypothalamus in mediating hunger and satiety. These insights have brought us closer to the development of rational therapies of obesity, the epidemic of which is continuing in the post-industrial society, which is characterised by sedentary behaviour patterns.
Larsen
Philip J
PJ
Steno Diabetes Center, DK-2820 Gentofte. oluf@steno.dk.
Echwald
Søren M
SM
Sørensen
Thorkild I A
TI
Pedersen
Oluf Borbye
OB
D000818:Animals; D001066:Appetite / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology; D051379:Mice; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000378:metabolism; D054411:Receptors, Leptin; D012527:Satiation / Q000502:physiology
D011956:Receptors, Cell Surface; D054411:Receptors, Leptin