title: Fatal lactic acidosis due to leukemic transformation in a patient with non-Hodgkin's lymphoma: case report.
abstract: Lactic acidosis (LA) associated with hematologic malignancies is uncommon, life-threatening, and generally occurs in adults. Its pathogenesis is poorly understood. This is a case report of LA due to leukemic transformation that occurred in a patient with non-Hodgkin's lymphoma (NHL). A 24-year-old man with NHL was admitted to the hospital with dyspnea. Venous blood gas analysis revealed metabolic acidosis (pH 7.05; HCO3 6 mEq/L; BE 22 mmol/L; anion gap 28 mEq/L); the patient had an elevated plasma lactate concentration (12 mmol/L) and low glucose concentration (38 mg/dL). There was no reason other than leukemia-such as infection, circulatory failure, or drug use-for the development of severe LA. This case report shows that in patients with NHL, leukemic transformation may give rise to LA.
authors.affiliation: Division of Nephrology, Yüzüncü Yil University, Van, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Dogan
authors.forename: Reha
authors.initials: R
authors.lastname: Erkoc
authors.forename: Hayriye
authors.initials: H
authors.lastname: Sayarlioglu
authors.forename: Suleyman
authors.initials: S
authors.lastname: Alici
authors.forename: Imdat
authors.initials: I
authors.lastname: Dilek
authors.forename: Ozlem
authors.initials: O
authors.lastname: Alici
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology*; D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications*; D008297:Male