title: Anti-diabetic effect of alkaline-reduced water on OLETF rats.
abstract: Alkalin-reduced water (ARW) is known to exert several anti-cancer effects, as well as to scavenge reactive oxygen species (ROS) and reduce blood-glucose levels. This study was performed in order to determine the effects of ARW on the control of spontaneous diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. We assigned 16 male OLETF rats (4 wk) to two groups: an experimental group, which was given ARW, and a control group, which received laboratory tap water. From week 6 to 32, the body weight, lipid composition, and glucose levels in the blood of the rats were measured. The glucose levels of both groups tended to increase. However, the ARW group's glucose levels were significantly lower than those of the control group after 12 weeks (p<0.05). The total cholesterol and triglyceride levels in the ARW group were found to be significantly lower than those of the control group during the experimental period. These results suggest that ARW spurred the growth of OLETF rats during the growth stage, and that long-term ingestion of ARW resulted in a reduction in the levels of glucose, triglycerides, and total cholesterol in the blood.
authors.affiliation: Department of Microbiology, Wonju College of Medicine, Yonsei University, Korea.
authors.forename: Dan
authors.initials: D
authors.lastname: Jin
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Ryu
authors.forename: Hyun Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Yang
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Lim
authors.forename: Yong Suk
authors.initials: YS
authors.lastname: Ryang
authors.forename: Choon Hee
authors.initials: CH
authors.lastname: Chung
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Kyu Jae
authors.initials: KJ
authors.lastname: Lee
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000468:Alkalies / Q000737:chemistry*; D000818:Animals; D001066:Appetite; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051381:Rats; D020334:Rats, Inbred OLETF; D014867:Water / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000468:Alkalies; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D008074:Lipoproteins; D014867:Water; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase