Recurrent hyponatremia after intrathecal methotrexate not related to antidiuretic hormone: is a natriuretic peptide activated?
We report the development of recurrent hyponatremia after intrathecal methotrexate that was not associated with elevated levels of antidiuretic hormone. We speculate that a central nervous system natriuretic peptide may be involved in the pathogenesis of the naturesis following intrathecal methotrexate.
Diskin
Charles
C
Hypertension, Nephrology, Dialysis and Transplantation Clinic, Auburn University, Opelika, AL 36801, USA. hndt512@bellsouth.net
Dansby
Linda M
LM
Radcliff
Lautrec
L
Carter
Thomas B
TB
Graves
Edith
E
Graves
Allen
A
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007278:Injections, Spinal; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D045265:Natriuretic Peptides / Q000378:metabolism*; D012008:Recurrence; D014667:Vasopressins / Q000502:physiology*
D000964:Antimetabolites, Antineoplastic; D045265:Natriuretic Peptides; D014667:Vasopressins; D008727:Methotrexate