title: Psoriatic arthritis and Klinefelter syndrome: case report.
abstract: Psoriatic arthritis (PsA) is a well-known disease characterized by psoriasis and inflammatory joint disease, with distinct clinical and radiological features to differentiate it from other arthropathies. Whereas many cases of coexistence of arthritis and other autoimmune disorders with chromosomal abnormalities have been reported, the occurrence of PsA and Klinefelter syndrome has not been reported previously. A case of Klinefelter syndrome and PsA was reported. This case report emphasizes the role played by sex hormones and chromosomal abnormalities in the pathogenesis of autoimmune disorder, and to our knowledge, this is an uncommon case of a patient with Klinefelter syndrome who developed PsA.
authors.affiliation: Department of Rheumatology, University of Foggia ''D'Avanzo'' Hospital, Viale degli Aviatori n.1, Foggia, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Melillo
authors.forename: A
authors.initials: A
authors.lastname: Corrado
authors.forename: L
authors.initials: L
authors.lastname: Quarta
authors.forename: F
authors.initials: F
authors.lastname: D'Onofrio
authors.forename: F P
authors.initials: FP
authors.lastname: Cantatore
mesh_terms: D000728:Androgens / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D012460:Sulfasalazine / Q000627:therapeutic use; D013739:Testosterone / Q000627:therapeutic use
chemical_list: D000728:Androgens; D018501:Antirheumatic Agents; D012460:Sulfasalazine; D013739:Testosterone; D008727:Methotrexate