[The relationship between the five beta-fibrinogen gene polymorphisms and cerebral infarction].
OBJECTIVE
To investigate the relationship among beta-fibrinogen (Fg) concentration, related gene polymorphisms (including -148C/T, -249C/T, -455G/A, 448G/A, 1689T/G) and cerebral infarction.


METHODS
Fg level and its five gene polymorphisms were analyzed with by polymerase chain reaction-restriction fragment length polymorphism in 132 patients with cerebral infarction, 79 patients with other neurological diseases and 92 healthy elders.


RESULTS
The plasma Fg level in cerebral infarction patients was significantly higher than that in the patients with other neurological diseases or healthy elders (P < 0.05). In the three groups, the plasma Fg levels in individuals with T-148 and A-455 alleles were higher than those in individuals without T-148 and A-455 alleles (P < 0.05). However, there were no statistically significant differences in the genotype and allele frequencies in the five mutation gene polymorphisms among the three groups (P > 0.05).


CONCLUSIONS
Cerebral infarction is a multifactorial disease and an increased Fg level is a risk factor for cerebral infarction. T-148 and A-455 allele can lead to elevated Fg concentration.
Fu
Yi
Y
Department of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Wei
Xin
X
Ni
Pei-hua
PH
Ying
Ya-yun
YY
Song
Yan-yan
YY
Chen
Sheng-di
SD
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D005340:Fibrinogen