Antibiotic coating reduces penile prosthesis infection.
OBJECTIVE
To evaluate the efficacy of a new antibiotic-coated (rifampicin+monocycline) penile prosthesis in prevention of bacterial adhesion and reduction of penile prosthesis infection.


METHODS
In a retrospective analysis of medical records of men who had undergone implantation of American Medical Systems (AMS) inflatable penile prostheses between July 1990 and November 2003, we compared patients with AMS antibiotic-coated prostheses and patients with AMS nonantibiotic-coated prostheses. A total of 152 men aged from 27 to 79 years with erectile dysfunction underwent implantation of the AMS inflatable penile prosthesis. Fifty-eight patients received the antibiotic-coated prosthesis between July 2001 and November 2003, and 94 patients received the nonantibiotic-coated prosthesis between July 1990 and June 2001.


RESULTS
In most cases infection was present; it was detected 1-2 days or up to 3-6 months after implantation. Complications including infection, which required surgical intervention, were observed in 15 patients of the nonantibiotic-coated prosthesis group (three reoperations for infection), and noninfection-related failure in five patients of the antibiotic-coated prosthesis group. In the nonantibiotic-coated prosthesis group of patients, time to infection ranged from 1 day to 6 months (mean 3.5 months). The antibiotic-coated prosthesis group of patients immediately after surgery and during the short- and intermediate-term follow-up had no infection of the penile prosthesis.


CONCLUSIONS
We suggest that the antibiotic locally delivered from the prosthesis coating might be an effective supplement for prevention of prosthesis-related infection in penile prosthesis surgery.
Droggin
Dmitry
D
Department of Urology, University of Columbia, New York, NY 10032, USA. dima_A_d@mail.ru
Shabsigh
Ridwan
R
Anastasiadis
Aristotelis G
AG
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016022:Case-Control Studies; D004338:Drug Combinations; D016503:Drug Delivery Systems; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage* / Q000627:therapeutic use; D019935:Penile Implantation / Q000379:methods*; D015917:Penile Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012293:Rifampin / Q000008:administration & dosage* / Q000627:therapeutic use; D018570:Risk Assessment
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D008911:Minocycline; D012293:Rifampin