title: Mucinous eccrine adenocarcinoma of the periocular region.
abstract: OBJECTIVE
  To report 4 patients with mucinous eccrine adenocarcinoma of the periocular region.
  
  
  METHODS
  Interventional case series of 4 patients with mucinous eccrine adenocarcinoma of the periocular region treated at 2 centers.
  
  
  RESULTS
  Two patients with mucinous eccrine adenocarcinoma of the upper eyelid, 1 with mucinous eccrine adenocarcinoma of the lower eyelid, and 1 with mucinous eccrine adenocarcinoma of the eyebrow were included in this report. The lower eyelid lesion and the eyebrow lesion recurred after Mohs micrographic surgery. Both recurrent lesions were treated with Mohs micrographic surgery and postoperative adjuvant external-beam radiation therapy. The other 2 primary tumors were treated with wide local excision with frozen section control of margins and did not recur. The follow-up time after the most recent surgical procedure ranged from 8 to 17 months (median, 12 months).
  
  
  CONCLUSIONS
  Mucinous eccrine adenocarcinoma is a rare ocular adnexal neoplasm that can involve the eyelid and periocular skin, can be locally invasive, and has a high risk of local recurrence despite Mohs surgery.
authors.affiliation: Department of Ophthalmology, University of Colorado Health Sciences Center, Denver, USA.
authors.forename: Vikram D
authors.initials: VD
authors.lastname: Durairaj
authors.forename: Eric M
authors.initials: EM
authors.lastname: Hink
authors.forename: Malik Y
authors.initials: MY
authors.lastname: Kahook
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hawes
authors.forename: Parwathi U
authors.initials: PU
authors.lastname: Paniker
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D000369:Aged, 80 and over; D001706:Biopsy; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015580:Mohs Surgery / Q000379:methods; D018714:Radiotherapy, Adjuvant; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery