Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan.
OBJECTIVE
To investigate the relationship between the metabolic syndrome and its related factors among non-diabetic pre- and post-menopausal women in North Taiwan.


METHODS
A cross-sectional study in a medical center in North Taiwan.


METHODS
Five hundred and ninety-four, non-diabetic middle-aged women (age range=40-64 years, mean=48.9+/-5.4 years) were recruited.


METHODS
The fasting plasma glucose, insulin, lipids levels and anthropometric indices were measured. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMA-IR). Metabolic syndrome was defined by using the National Cholesterol Education Panel (NCEP) criteria and modified NCEP criteria (waist circumference >80 cm).


RESULTS
The prevalence of metabolic syndrome was 6.2% using NCEP criteria, and 8.9% using modified NCEP criteria. Post-menopausal women had a higher prevalence of metabolic syndrome and its individual components compared to pre-menopausal women except hyperglycemia and low HDL-C. In multiple logistic regression analysis with adjustment for age and menopausal status, both BMI and HOMA-IR were independently associated with the metabolic syndrome.


CONCLUSIONS
The prevalence of metabolic syndrome was higher in post-menopausal than pre-menopausal women. Both obesity and insulin resistance may play an important role in the development of metabolic syndrome among the middle-aged women in North Taiwan.
Lin
W-Y
WY
Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yang
W-S
WS
Lee
L-T
LT
Chen
C-Y
CY
Liu
C-S
CS
Lin
C-C
CC
Huang
K-C
KC
D000328:Adult; D000886:Anthropometry; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000208:ethnology; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids