title: Ultrasound assessment of detrusor thickness in children and young adults with myelomeningocele.
abstract: OBJECTIVE
  We determine by ultrasonography the range of dT in carefully treated and followed children with myelomeningocele, and evaluate the role of such measurements for the understanding of bladder abnormalities in these patients.
  
  
  METHODS
  We studied 66 children and young adults with MMC (34 males and 32 females, median age 8.1 years, range 1.1 to 20.1). Detrusor thickness was measured with a previously established ultrasonographic technique and the results were compared to those in normal children. The variation in detrusor thickness with degree of bladder dysfunction as well as with bladder wall trabeculation, kidney function and anticholinergic treatment was studied.
  
  
  RESULTS
  The detrusor of the ventral wall was slightly thinner in children with MMC compared to normal. No significant variation in dT was found for different degrees of bladder dysfunction, bladder wall trabeculation, kidney function or anticholinergic treatment. Boys had thicker detrusor of the ventral wall than girls.
  
  
  CONCLUSIONS
  Children with MMC, followed closely and treated according to international standards, do not acquire detrusor thickening as measured by ultrasonography. The detrusor thickness did not correlate with the degree of bladder dysfunction or renal function, or with anticholinergic treatment. Bladder wall trabeculation at VCU was not associated with bladder wall thickening on ultrasonography. We postulate that in a closely monitored and actively treated population of patients with MMC muscular hypertrophy and the development of connective tissue in the bladder wall is kept to a minimum.
authors.affiliation: Department of Pediatric Radiology, Queen Silvia Children's Hospital, Göteborg, Sweden. lennart.muller@lthalland.se
authors.forename: L
authors.initials: L
authors.lastname: Müller
authors.forename: K
authors.initials: K
authors.lastname: Abrahamsson
authors.forename: U
authors.initials: U
authors.lastname: Sillén
authors.forename: B
authors.initials: B
authors.lastname: Jacobsson
authors.forename: A
authors.initials: A
authors.lastname: Odén
authors.forename: M
authors.initials: M
authors.lastname: Hellström
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008591:Meningomyelocele / Q000150:complications*; D014463:Ultrasonography; D001743:Urinary Bladder / Q000000981:diagnostic imaging* / Q000473:pathology*