title: Should pre-operative troponin be a standard requirement in patients undergoing major lower extremity amputation?
abstract: OBJECTIVE
  The objective of this study was to ascertain the benefit of routine pre-operative cardiac troponin I (cTnI) measurement in patients undergoing major lower extremity amputation for critical limb ischaemia.
  
  
  METHODS
  This was a prospective, blinded observational study.
  
  
  METHODS
  All patients scheduled for lower extremity amputation, without evidence of unstable coronary artery disease were recruited prospectively over a period of 1 year. In addition to routine pre-operative evaluation, a blood sample was taken for measurement of serum cTnI. Post-operative screening was conducted for cardiac events with patients followed up to 6 weeks.
  
  
  RESULTS
  Ten of the 44 patients included suffered a non-fatal myocardial infarction or died from a cardiac cause post-operatively. A rise in pre-operative cTnI was associated with a very poor outcome (two cardiac deaths and one post-operative myocardial infarction) and was the only significant predictor of post-operative cardiac events.
  
  
  CONCLUSIONS
  Routine pre-operative cTnI measurement may be of use to identify patients at high risk of cardiac complication who would benefit from optimization of cardiac status or in whom surgery could be deferred.
authors.affiliation: Department of General and Vascular Surgery, Gartnavel General Hospital, Glasgow, UK. simoncgibson@hotmail.com
authors.forename: S C
authors.initials: SC
authors.lastname: Gibson
authors.forename: A
authors.initials: A
authors.lastname: Marsh
authors.forename: C
authors.initials: C
authors.lastname: Berry
authors.forename: C
authors.initials: C
authors.lastname: Payne
authors.forename: D S
authors.initials: DS
authors.lastname: Byrne
authors.forename: P N
authors.initials: PN
authors.lastname: Rogers
authors.forename: A J
authors.initials: AJ
authors.lastname: McKay
authors.forename: H
authors.initials: H
authors.lastname: Dargie
authors.forename: D B
authors.initials: DB
authors.lastname: Kingsmore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000401:mortality; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000401:mortality; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000601:surgery; D035002:Lower Extremity / Q000098:blood supply / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000401:mortality; D011300:Preoperative Care; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I