The Neber route to substituted indoles.
Two complementary procedures have been developed for the conversion of the oximes of alpha-aryl ketones to azirines. On heating, the azirines rearrange smoothly to the corresponding indoles. The overall transformation offers a versatile route to indoles, complementary to the Fischer indole synthesis.
Taber
Douglass F
DF
Department of Chemistry and Biochemistry, University of Delaware, Newark, 19716, USA. taberdf@udel.edu
Tian
Weiwei
W
D007211:Indoles / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry; D010091:Oximes / Q000737:chemistry
D007211:Indoles; D007659:Ketones; D010091:Oximes