Regional cerebral blood flow changes in a patient with delusional parasitosis before and after successful treatment with risperidone: a case report.
The pathophysiology and appropriate pharmacological interventions for delusional parasitosis (DP) remain unknown. Here, we present a case of DP following brain infarction of the right temporoparietal region. Pharmacotherapy with risperidone resulted in a dramatic therapeutic response over a short period. In a sequential N-isopropyl-p-[(123)I]-iodoamphetamine single photon emission computed tomography ([(123)I]-IMP SPECT) study, post-treatment SPECT images revealed a marked increase of rCBF in the large areas including the bilateral frontal and left temporoparietal regions, the right parietal operculum and the bilateral basal ganglia, in contrast to pre-treatment SPECT images showing a global decrease of rCBF. Our clinical outcome suggests the efficacy and safety of risperidone for treatment of DP and that both dopaminergic and serotonergic dysfunction may play a role in DP. Our sequential SPECT findings suggest that psychiatric improvement of DP is associated with increased rCBF.
Narumoto
Jin
J
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. jnaru@koto.kpu-m.ac.jp
Ueda
Hideki
H
Tsuchida
Hideto
H
Yamashita
Tatsuhisa
T
Kitabayashi
Yurinosuke
Y
Fukui
Kenji
K
D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010272:Parasitic Diseases / Q000523:psychology*; D012039:Regional Blood Flow / Q000187:drug effects; D018967:Risperidone / Q000627:therapeutic use*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D014150:Antipsychotic Agents; D018967:Risperidone