Uterine artery embolization versus myomectomy: a multicenter comparative study.
OBJECTIVE
To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE) and to compare UAE and myomectomy outcomes.


METHODS
Prospective cohort controlled study.


METHODS
Sixteen medical centers in the United States.


METHODS
One hundred forty-nine UAE patients and 60 myomectomy patients. Patients were assigned to myomectomy or UAE on the basis of a best treatment decision made by the patient and her physician. All patients were observed for 6 months. The UAE patients also had follow-up examinations at 1 year.


METHODS
Myomectomy or UAE.


METHODS
Quality of life score changes, menstrual bleeding score changes, uterine size differences, time off, and adverse events.


RESULTS
Both groups experienced statistically significant improvements in the uterine fibroid quality of life score, menstrual bleeding, uterine volume, and overall postoperative quality of life. The mean hospital stay was 1 day for the UAE patients, compared with 2.5 days for the myomectomy patients. The UAE and myomectomy patients returned to their normal activities in 15 days and 44 days, respectively, and returned to work in 10 days and 37 days, respectively. At least one adverse event occurred in 40.1% of the myomectomy patients, compared with 22.1% in the UAE group.


CONCLUSIONS
The uterine fibroid quality of life score was significantly improved in both groups. No significant differences were observed in bleeding improvement, uterine volume reduction, uterine fibroid quality of life score improvement, and overall quality of life score improvement between groups. Patients receiving UAE required fewer days off work, fewer hospital days, and experienced fewer adverse events.
Goodwin
Scott C
SC
Department of Veterans Affairs, The University of California, Los Angeles, California, USA. scott.goodwin@med.va.gov
Bradley
Linda D
LD
Lipman
John C
JC
Stewart
Elizabeth A
EA
Nosher
John L
JL
Sterling
Keith M
KM
Barth
Merle H
MH
Siskin
Gary P
GP
Shlansky-Goldberg
Richard D
RD
D000328:Adult; D001158:Arteries; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007889:Leiomyoma / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D007902:Length of Stay; D009215:Myometrium / Q000601:surgery; D011183:Postoperative Complications; D011446:Prospective Studies; D011788:Quality of Life; D018582:Sick Leave; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D014599:Uterus / Q000098:blood supply / Q000473:pathology