Inhalational model of cocaine exposure in mice: neuroteratological effects.
We developed a novel inhalation-based mouse model of prenatal cocaine exposure. This model approximates cocaine abuse via smoking, the preferred route of cocaine administration by heavy drug users. The model is also characterized by (i) absence of procedural stress from drug administration, (ii) long-term drug exposure starting weeks before pregnancy and continuing throughout the entire gestation, and (iii) self-administration of cocaine in multi-hour daily sessions reminiscent of drug binges, which allows animals to set up the levels of their own drug consumption. The offspring of female mice inhaling cocaine in our model displayed no gross alterations in their cortical cytoarchitecture. These offspring, however, showed significant impairments in sustained attention and spatial working memory. We hope that the introduction of the present model will lead to a significant increase in our understanding of outcomes of prenatal cocaine exposure.
He
Fang
F
Department of Biomedical Sciences and Program of Neuroscience, University of Maryland, Baltimore, 5-A-12, HHH, 666 W. Baltimore St., Baltimore, MD 21201, USA.
Lidow
Irina A
IA
Lidow
Michael S
MS
D000280:Administration, Inhalation; D000704:Analysis of Variance; D000818:Animals; D001288:Attention / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D003042:Cocaine / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D019970:Cocaine-Related Disorders / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004064:Digestive System / Q000187:drug effects; D004195:Disease Models, Animal; D018765:Dopamine Uptake Inhibitors / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011851:Radioactivity; D012867:Skin / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects; D013997:Time Factors; D014316:Tritium / Q000097:blood / Q000493:pharmacokinetics
D018765:Dopamine Uptake Inhibitors; D014316:Tritium; D003042:Cocaine