Ketotifen improves sperm motility and sperm morphology in male patients with leukocytospermia and unexplained infertility.
In an open, uncontrolled study, the effect of 12 weeks of daily administration of ketotifen, an antihistamine-like drug with a mast cell stabilizing effect, on the semen quality of 55 men with leukocytospermia and unexplained infertility was examined. After 4 weeks of treatment, white blood cell count dramatically diminished and was accompanied by a significant improvement in sperm motility. A significant increase of morphologically normal sperm cells was observed at 8 weeks of treatment, and these changes remained until at least 4 weeks after the end of treatment.
Oliva
Alejandro
A
Unidad de Andrologia, Servicio de Urologia, Hospital Italiano de Rosario, Rosario, Argentina.
Multigner
Luc
L
D000328:Adult; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000473:pathology; D007665:Ketotifen / Q000008:administration & dosage*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*
D006634:Histamine H1 Antagonists; D007665:Ketotifen