Release behaviors of porous poly(butylene succinate)/poly(epsilon-caprolactone) microcapsules containing indomethacin.
The biodegradable poly(butylene succinate)/poly(epsilon-caprolactone) (PBS/PCL) microcapsules containing indomethacin were prepared by emulsion solvent evaporation method. The morphologies, thermal properties, and release behaviors of PBS/PCL microcapsules were investigated. As a result, the microcapsules exhibited porous and spherical form in the presence of gelatin as a surfactant. From the DSC result, the PBS/PCL microcapsules showed the two exothermic peaks meaning the melting points of PCL and PBS. The results of FT-IR and DSC proved that the PBS and PCL were mixed so that the PBS/PCL microcapsules were composed of two wall-forming materials. And the release rate of indomethacin from the microcapsules was decreased with increasing the PCL content. It was noted that an addition of PCL on the PBS led to the decrease of pore size in the PBS/PCL microcapsules.
Park
Soo-Jin
SJ
Advanced Materials Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Daejeon 305-600, Republic of Korea. psjin@krict.re.kr
Lee
Yun-Mok
YM
Hong
Sung-Kwon
SK
D002072:Butylene Glycols / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D007213:Indomethacin / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors
D002072:Butylene Glycols; D002214:Capsules; D011091:Polyesters; D011108:Polymers; C089797:bionole; C016240:polycaprolactone; D007213:Indomethacin