title: Periventricular leukomalacia specifically affects cortical MEG response to biological motion.
abstract: OBJECTIVE
  Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity.
  
  
  METHODS
  Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL.
  
  
  RESULTS
  Dynamics of MEG activity parallel behavioral deficits. Early (140-170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls.
  
  
  CONCLUSIONS
  This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL.
authors.affiliation: Department of Paediatric Neurology and Child Development, Children's Hospital, University of Tübingen Medical School, Tübingen, Germany. marina.pavlova@uni-tuebingen.de
authors.forename: Marina
authors.initials: M
authors.lastname: Pavlova
authors.forename: Fabio
authors.initials: F
authors.lastname: Marconato
authors.forename: Alexander
authors.initials: A
authors.lastname: Sokolov
authors.forename: Christoph
authors.initials: C
authors.lastname: Braun
authors.forename: Niels
authors.initials: N
authors.lastname: Birbaumer
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Krägeloh-Mann
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology / Q000503:physiopathology; D007969:Leukomalacia, Periventricular / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography; D008297:Male; D009038:Motion; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology