[Effect of respiratory infections on the clinical course of coronary artery disease].
The subjects of the study were 64 patients with coronary artery disease (CAD), and 38 healthy controls. The study included determination of Chlamydia pneumonia (CLPN), Toxoplasma gondii (TG), Herpes simplex virus (HSV) 1, 2, Epstein-Barr virus (EBV), and antibodies to these microorganisms. Diagnostically significant elevation of the serum levels of IgG antibodies to CLPN, HSV 1, 2, or TG was associated with CAD progression, and seropositivity to several of the agents strongly correlated with CAD progression. Moreover, the risk of future coronary events increased depending on the level of total pathogen burden. These results suggest that intracellular infectious agents are involved in the development of atherosclerosis and CAD.
Lobzin
Iu V
IuV
Boĭtsov
S A
SA
Filippov
A E
AE
Linchak
R M
RM
Mangutov
D A
DA
D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000209:etiology* / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D012307:Risk Factors; D012720:Severity of Illness Index
D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D007074:Immunoglobulin G