Preeclampsia: the death of Goliath.
In this review, a novel and unifying pathophysiologic mechanism of preeclampsia is presented whereby a minimal excess of placental immune complex production versus removal causes a proinflammatory autoamplification cascade of trophoblast apoptosis/necrosis and oxidative stress, culminating in clinical preeclampsia. This concept immediately leads to a plethora of new and robust therapeutic strategies.
Feinberg
Bruce B
BB
Women's Health Associates, 101 Prospect Street, Suite 202, Lakewood, NJ 08701, USA. bfeinberg@sbhcs.com
D000936:Antigen-Antibody Complex / Q000096:biosynthesis / Q000502:physiology* / Q000627:therapeutic use; D003165:Complement System Proteins / Q000502:physiology; D005260:Female; D017359:HELLP Syndrome / Q000628:therapy; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D011247:Pregnancy
D000936:Antigen-Antibody Complex; D003165:Complement System Proteins