[Antihypoxant and antiamnesic effects of calcium ketopantoylaminobutyrate].
Experimental investigation of calcium ketopantoylaminobutyrate (Ca-KPAB), a new drug with a structure close to that of pantogam, showed that Ca-KPAB exhibits a pronounced antihypoxant effect on the normobaric and histotoxic hypoxia models. The new drug also produced a more pronounced antiamnesic action as compared to that of pantogam. A significant decrease in the effective drug dose in the case of Ca-KPAB is explained by its ability to readily bypass the blood - brain barrier.
Karavaev
A L
AL
Kozlova
G S
GS
Smirnova
T N
TN
Gunar
V I
VI
D000613:Aminobutyrates / Q000008:administration & dosage* / Q000378:metabolism; D000647:Amnesia / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000378:metabolism; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000613:Aminobutyrates; D018697:Nootropic Agents; C504809:ketopantoyl aminobutyric acid; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid