Latex allergy: a follow up study of 1040 healthcare workers.
BACKGROUND
Natural rubber latex allergy can cause skin and respiratory symptoms The aim of this study was to evaluate the prevalence and incidence of latex related symptoms and sensitisation among a large group of healthcare workers in Trieste hospitals, followed for three years before and after the introduction of powder-free gloves with low latex release.


METHODS
In the years 1997-99 the authors evaluated 1040 healthcare workers exposed to latex allergen for latex related symptoms and sensitisation by means of a questionnaire, a medical examination, skin prick tests, and IgE specific antibody assay. The second evaluation was carried out in the years 2000-02, subsequent to the changeover to a powder-free environment.


RESULTS
Glove related symptoms were seen in 21.8% of the nurses (227), mostly consisting of mild dermatitis: 38 (3.6%) complaining of contact urticaria and 24 (2.3%) of asthma and/or rhinitis. These symptoms were significantly related to skin prick tests positive to latex (OR = 9.70; 95% CI 5.5 to 17) and to personal atopy (OR = 2.29; 95% CI 1.6 to 3.2). Follow up was completed in 960 subjects (92.3%): 19 new subjects (2.4%) complained of itching erythema when using gloves, but none was prick positive to latex. Symptoms significantly improved and in most cases disappeared (p<0.0001).


CONCLUSIONS
Simple measures such as the avoidance of unnecessary glove use, the use of non-powdered latex gloves by all workers, and use of non-latex gloves by sensitised subjects can stop the progression of latex symptoms and can avoid new cases of sensitisation.
Filon
F Larese
FL
UCO Medicina del Lavoro, Dipartimento di Scienze di Medicina Pubblica, Università degli Studi di Trieste, Trieste, Italy. Larese@univ.trieste.it
Radman
G
G
D000328:Adult; D017677:Age Distribution; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000209:etiology; D004812:Epidemiologic Methods; D005260:Female; D017575:Gloves, Protective / Q000009:adverse effects; D006801:Humans; D007558:Italy / Q000453:epidemiology; D020315:Latex Hypersensitivity / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D010564:Personnel, Hospital; D011208:Powders; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D012882:Skin Tests / Q000379:methods
D011208:Powders