title: The relationship of working memory, inhibition, and response variability in child psychopathology.
abstract: BACKGROUND
  The aim of this study was to investigate the relationship between working memory and inhibition in children with attention deficit hyperactivity disorder (ADHD), high-functioning autism (HFA), and Tourette syndrome (TS), compared to normally developing children. Furthermore, the contribution of variation in processing speed on working memory and inhibition was investigated in these childhood psychopathologies.
  
  
  METHODS
  Four groups of children are reported in this study: 65 children with ADHD, 66 children with HFA, 24 children with TS, and 82 normal control children. All children were in the age range of 6-13 years.
  
  
  RESULTS
  The relationship between working memory and inhibition was similar in children with ADHD, HFA, TS, and normally developing children. The relationship between both domains did not alter significantly for any of the groups, when variation in processing speed was taken into account. More symptoms of hyperactivity/impulsivity are related to a poorer inhibitory process and greater response variability. More symptoms of autism are related to a poorer working memory process.
  
  
  CONCLUSIONS
  The current study showed that working memory, inhibition, and response variability, are distinct, but related cognitive domains in children with developmental psychopathologies. Research with experimental manipulations is needed to tackle the exact relationship between these cognitive domains.
authors.affiliation: Department of Psychology, Ghent University, Belgium. sylvie.verte@UGent.be
authors.forename: Sylvie
authors.initials: S
authors.lastname: Verté
authors.forename: Hilde M
authors.initials: HM
authors.lastname: Geurts
authors.forename: Herbert
authors.initials: H
authors.lastname: Roeyers
authors.forename: Jaap
authors.initials: J
authors.lastname: Oosterlaan
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Sergeant
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000503:physiopathology*; D001321:Autistic Disorder / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011340:Problem Solving / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013223:Statistics as Topic; D005879:Tourette Syndrome / Q000503:physiopathology*