title: Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?
abstract: This study was carried out to evaluate the antifibrotic effect of ethanol extract of the fruits of Indian herb Piper longum Linn. Liver fibrosis was induced in rats by CCl(4) administration. The extent of liver fibrosis was assessed by measuring the level of liver hydroxy proline (HP) and serum enzyme levels. Following CCl(4) administration HP was significantly increased and serum enzyme levels were elevated. Treatment with the ethanol extract of Piper longum Linn. reduced the HP and also the serum enzymes. The liver weight that increased following CCl(4) administration due to the deposition of collagen was reduced by the ethanol extract. Hence, it is concluded that this extract inhibits liver fibrosis induced by CCl(4).
authors.affiliation: Department of Pharmacology, KM College of Pharmacy, Uthangudi, Madurai, Tamil Nadu, India. tinatina38@rediffmail.com
authors.forename: A J M
authors.initials: AJ
authors.lastname: Christina
authors.forename: G R
authors.initials: GR
authors.lastname: Saraswathy
authors.forename: S J Heison
authors.initials: SJ
authors.lastname: Robert
authors.forename: R
authors.initials: R
authors.lastname: Kothai
authors.forename: N
authors.initials: N
authors.lastname: Chidambaranathan
authors.forename: G
authors.initials: G
authors.lastname: Nalini
authors.forename: R L
authors.initials: RL
authors.lastname: Therasal
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride; D000431:Ethanol; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D031701:Piper / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D000431:Ethanol; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D006909:Hydroxyproline