title: Risk factors and long-term outcome of transplant renal artery stenosis in adult recipients after treatment by percutaneous transluminal angioplasty.
abstract: Transplant renal artery stenosis (TRAS) is a common complication of kidney transplantation but attempts to identify predisposing risk factors for TRAS have yielded conflicting results. In order to determine the predisposing factors for transplant (TRAS), we retrospectively reviewed the records of 29 renal allograft recipients with TRAS treated with percutaneous transluminal angioplasty (PTA). The TRAS group was compared with a case-control group of 58 patients. Predisposing factors for TRAS included CMV infection (41.4% vs. 12.1% p = 0.0018) and initial delayed graft function (DGF) (48.3% vs. 15.5% p = 0.0018), respectively in the TRAS and the control group. Acute rejection occurred more frequently in patients from the TRAS group (48.3%) compared with the control group (27.6%), although the difference was not significant (p = 0.06). In a multivariate analysis, only CMV infection (p = 0.005) and DGF (p = 0.009) appear to be significantly and independently associated with TRAS. The long-term graft survival was significantly higher in the control group, compared with the TRAS group (p = 0.03). Our study suggests that CMV infection and DGF are two reliable risk factors for TRAS. Despite treatment by PTA with primary successful results, TRAS significantly affects long-term graft outcome.
authors.affiliation: Department of Nephrology and Transplantation and Université Paris XII, Henri Mondor Hospital, Créteil, France.
authors.forename: V
authors.initials: V
authors.lastname: Audard
authors.forename: M
authors.initials: M
authors.lastname: Matignon
authors.forename: F
authors.initials: F
authors.lastname: Hemery
authors.forename: R
authors.initials: R
authors.lastname: Snanoudj
authors.forename: P
authors.initials: P
authors.lastname: Desgranges
authors.forename: M C
authors.initials: MC
authors.lastname: Anglade
authors.forename: H
authors.initials: H
authors.lastname: Kobeiter
authors.forename: A
authors.initials: A
authors.lastname: Durrbach
authors.forename: B
authors.initials: B
authors.lastname: Charpentier
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.forename: P
authors.initials: P
authors.lastname: Grimbert
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon; D016022:Case-Control Studies; D003586:Cytomegalovirus Infections / Q000150:complications*; D051799:Delayed Graft Function / Q000150:complications; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D012078:Renal Artery Obstruction / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D012307:Risk Factors; D016896:Treatment Outcome