Evaluating the role of human papillomaviruses in conjunctival neoplasia.
Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putative new HPV, and two mucosal HPVs were detected in 25% (14 out of 56) of HIV-positive, in 10% (three out of 30) of HIV-negative conjunctival neoplasia samples, and rarely (0-1.6%) in control subjects. The absence of high-risk HPVs and the low detection frequency of EV-related HPV types in more advanced tumour stages (10%) raise doubts about their role in conjunctival carcinomas.
Tornesello
M L
ML
Viral Oncology and AIDS Reference Centre, National Cancer Institute Fond. Pascale, Cappella Cangiani, I-80131 Naples, Italy.
Duraturo
M L
ML
Waddell
K M
KM
Biryahwaho
B
B
Downing
R
R
Balinandi
S
S
Lucas
S B
SB
Buonaguro
L
L
Buonaguro
F M
FM
D000293:Adolescent; D000328:Adult; D003230:Conjunctival Neoplasms / Q000737:chemistry / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000821:virology*
D004279:DNA, Viral