title: [Deep brain stimulation in the posterior hypothalamus for chronic cluster headache. Case report and review of the literature].
abstract: Primary chronic cluster headache (CCH) is a rare but severe pain syndrome and pathophysiological explanations are still missing. PET studies revealed activation in the hypothalamus and therefore it became a target for therapeutic deep brain stimulation (DBS). A case of a 39-year-old woman and a literature review are presented. The patient suffered from left-sided primary CCH for 14 months. The headache was resistant to any pharmacological therapy or treatment was limited by major drug side effects. Using a stereotactic approach a quadripolar lead was inserted in the left posterior hypothalamus. A test trial was performed and attack frequency, intensity, and adverse events were noted. Intraoperative test stimulation evoked typical side effects like tachycardia, diplopia and panic attacks. During the trial test a marked reduction in frequency and intensity of CCH was recorded. After 7 days the stimulation device was implanted subcutaneously. DBS with implantation of a lead in the ipsilateral inferior posterior hypothalamus is an experimental treatment option and should be offered to selected patients in a prospective controlled clinical trial. Data concerning the long-term follow-up need to be collected.
authors.affiliation: Abteilung für Neurochirurgie, Campus Lübeck des Universitätsklinikums Schleswig-Holstein. Rasche@neurochirurgie.uni-luebeck.de
authors.forename: D
authors.initials: D
authors.lastname: Rasche
authors.forename: D
authors.initials: D
authors.lastname: Foethke
authors.forename: J
authors.initials: J
authors.lastname: Gliemroth
authors.forename: V M
authors.initials: VM
authors.lastname: Tronnier
mesh_terms: D000328:Adult; D003027:Cluster Headache / Q000175:diagnosis / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007034:Hypothalamus, Posterior / Q000502:physiology; D008279:Magnetic Resonance Imaging; D013238:Stereotaxic Techniques; D013997:Time Factors; D016896:Treatment Outcome