[The influence of aminostigmine on the parameters of nonspecific resistance and immune system of the organism upon acute poisoning of benzyl 3-quinuclidylate].
The results of experiments on outbred rats weighing 180 -240 g showed that the acute poisoning with benzyl 3-quinuclidylate decreases the parameters of nonspecific resistance of the organism, reduces the antibody production mainly to T-dependent antigens (sheep red blood cells), decreases the activity of natural killers and the antibody-dependent cell-mediated cytotoxicity, and suppresses the formation of delayed-type hypersensitivity. Aminostigmine partly inhibits the immunotoxicity benzyl 3-quinuclidylate.
Zabrodskiĭ
P F
PF
Troshkin
N M
NM
Germanchuk
V G
VG
Sidel'nikova
N M
NM
Lim
V G
VG
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects* / Q000276:immunology; D002219:Carbamates / Q000008:administration & dosage* / Q000276:immunology; D002618:Chemical Warfare; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D018727:Muscarinic Antagonists / Q000276:immunology / Q000506:poisoning*; D011725:Pyridines / Q000008:administration & dosage* / Q000276:immunology; D011729:Pyridostigmine Bromide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000276:immunology; D011813:Quinuclidinyl Benzilate / Q000037:antagonists & inhibitors / Q000276:immunology / Q000506:poisoning*; D051381:Rats
D002219:Carbamates; D018727:Muscarinic Antagonists; D011725:Pyridines; D011813:Quinuclidinyl Benzilate; C070102:aminostigmine; D011729:Pyridostigmine Bromide