Successful treatment of hepatitis B virus-associated membranous nephropathy with lamivudine.
We present a case of chronic hepatitis B with membranous nephropathy, that was improved by lamivudine treatment. A 37-year-old man was admitted to our hospital for the evaluation of proteinuria. He was diagnosed as having chronic glomerulonephritis associated with chronic hepatitis B. Histopathological findings of the renal biopsy specimen indicated membranous nephropathy. He suffered from nephrotic syndrome associated with leg edema, which was parallel to the exacerbation of hepatitis. Lamivudine was started for the treatment of hepatitis, which caused the disappearance of serum hepatitis B virus DNA and the normalization of ALT level in 4 weeks. Additionally, proteinuria disappeared 120 weeks after the treatment was started. Lamivudine treatment may remit HBV-associated nephropathy.
Okuse
C
C
Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan. C2okuse@marianna-u.ac.jp
Yotsuyanagi
H
H
Yamada
N
N
Ikeda
H
H
Takahashi
H
H
Suzuki
M
M
Kondo
S
S
Kimura
K
K
Koike
J
J
Itoh
F
F
D000328:Adult; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy* / Q000209:etiology; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D011507:Proteinuria / Q000188:drug therapy; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*
D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine