Transcription factor target practice.
In this issue of Cell, Hallikas et al. (2006) and Wei et al. (2006) describe different ways of identifying direct targets of transcription factors and their corresponding regulatory sequences in the genome. Although still under development, these studies provide an efficient way to decipher regulatory networks.
Holstege
Frank C P
FC
Department of Physiological Chemistry, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands. f.c.p.holstege@med.uu.nl
Clevers
Hans
H
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D053823:Hedgehog Proteins; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D051153:Wnt Proteins / Q000235:genetics
D002352:Carrier Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; C498447:Hhip protein, mouse; D008562:Membrane Glycoproteins; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D051153:Wnt Proteins; C077245:hh protein, Drosophila