title: Biocompatibility of nanofilm-encapsulated silicone and silicone-hydrogel contact lenses.
abstract: A material placed in or in contact with a biological system, that causes the minimum perturbation that can be tolerated by the host biological system, can be considered to be biocompatible. The major effects caused by a contact lens can be considered to be 1) the blocking of the natural supply of oxygen to the epithelium cells of the cornea, 2) interference with the normal evaporation of water from the tear fluid layer, and 3) hindrance of the normal functions of blinking for replenishing oxygen-saturated tear fluid and removing dead epithelium cells, which result from apoptosis. The encapsulation of a highly oxygen-permeable contact lens by a nanofilm with an imperturbable surface state minimizes all these terms. The encapsulated contact lens can be worn safely in extended wear.
authors.affiliation: Center for Surface Science and Plasma Technology, University of Missouri-Columbia, USA. YasudaH@missouri.edu
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Yasuda
mesh_terms: D001672:Biocompatible Materials; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects; D003315:Cornea / Q000502:physiology; D004058:Diffusion; D006801:Humans; D020100:Hydrogels; D008422:Materials Testing; D049329:Nanostructures; D010100:Oxygen / Q000378:metabolism; D011108:Polymers; D011312:Pressure; D012828:Silicones; D013499:Surface Properties; D013666:Tears / Q000502:physiology; D014867:Water / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers; D012828:Silicones; D014867:Water; D010100:Oxygen