title: Population-based demographic study of karyotypes in 1709 patients with adult acute myeloid leukemia.
abstract: Few large demographic studies of acute myeloid leukemia (AML) are derived from population-based registries. Demographic and karyotypic data were provided for AML cases from two regional leukemia registry databases in Scotland and the Northern Region of England. A population-based dataset was compiled, comprising 1709 patients aged >16 years (1235 North England/474 Scotland patients). The most common cytogenetic abnormalities involved chromosomes 5 and/or 7 (17%). Patients with the following abnormal chromosome 5/7 combinations: -5, del(5q), -5/-7 and del(5q)/-7 represented a significantly older population (P < 0.01, ANOVA). t(8;21) was the only 'favourable' karyotype found in older age. Karyotypic complexity varied within chromosome 5/7 combination groups; those containing -5, -5/-7, -5/del(7q), del(5q)/-7 or del(5q)/del(7q) combinations were significantly more frequently complex than those containing -7 and del(7q) (P < 0.01, chi2 test). Additional recurring cytogenetic abnormalities within complex karyotypes containing chromosome 5/7 combinations included (in order of frequency), abnormalities of chromosomes 17, 12, 3 and 18. Complex karyotypes not involving chromosomes 5 or 7 represented 30% of all complex karyotypes, occurred in younger patients than those involving chromosomes 5 and 7, and frequently included additional trisomy 8 (26%). In conclusion, we describe subgroups within adverse karyotypes, with different demographics, degree of complexity and additional chromosome abnormalities.
authors.affiliation: Division of Pathology & Neuroscience, University of Dundee, Dundee, UK.
authors.forename: R N
authors.initials: RN
authors.lastname: Sanderson
authors.forename: P R E
authors.initials: PR
authors.lastname: Johnson
authors.forename: A V
authors.initials: AV
authors.lastname: Moorman
authors.forename: E
authors.initials: E
authors.lastname: Roman
authors.forename: E
authors.initials: E
authors.lastname: Willett
authors.forename: P R
authors.initials: PR
authors.lastname: Taylor
authors.forename: S J
authors.initials: SJ
authors.lastname: Proctor
authors.forename: N
authors.initials: N
authors.lastname: Bown
authors.forename: S
authors.initials: S
authors.lastname: Ogston
authors.forename: D T
authors.initials: DT
authors.lastname: Bowen
mesh_terms: D000208:Acute Disease; D000328:Adult; D003710:Demography; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D011159:Population Surveillance; D012042:Registries