title: High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele.
abstract: We examined the relation between cutaneous melanoma risk and the intercellular adhesion molecule-1 (ICAM-1) gene single nucleotide polymorphisms G241R and K469E, as well as the circulating soluble form of ICAM-1 determined in plasma, in the population of Modena Province, northern Italy. Individuals carrying at least one R241 allele, versus those carrying the wild-type GG genotype, had a relative risk of melanoma of 4.3 (P = 0.022), whereas the K469E polymorphism was unrelated to disease risk. Soluble ICAM-1 levels above 10 ng/ml directly and strongly correlated with melanoma risk. In this population, individuals carrying the R241 allele of the ICAM-1 gene appeared to show an enhanced susceptibility to cutaneous melanoma, possibly because of increased ICAM-1 expression.
authors.affiliation: Department of Public Health Sciences, University of Modena and Reggio Emilia, Modena, Italy. marco.vinceti@unimore.it
authors.forename: Marco
authors.initials: M
authors.lastname: Vinceti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pellacani
authors.forename: Bruno
authors.initials: B
authors.lastname: Casali
authors.forename: Carlotta
authors.initials: C
authors.lastname: Malagoli
authors.forename: Davide
authors.initials: D
authors.lastname: Nicoli
authors.forename: Enrico
authors.initials: E
authors.lastname: Farnetti
authors.forename: Stefania
authors.initials: S
authors.lastname: Bassissi
authors.forename: Margherita
authors.initials: M
authors.lastname: Bergomi
authors.forename: Stefania
authors.initials: S
authors.lastname: Seidenari
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000235:genetics*; D007558:Italy; D008545:Melanoma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics*
chemical_list: D018799:Intercellular Adhesion Molecule-1