Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting.
CONCLUSIONS
Graphical modeling is used to extend the gene counting method to compute maximum likelihood estimates of allele frequencies for samples of individuals related in extended pedigrees. Genotypes may be missing or partially observed, and error rates can be simultaneously estimated.


BACKGROUND
The Java classes and Javadocs pages for \mathsf\hbox GeneCountAlleles can be obtained from bioinformatics.med.utah.edu/~alun, which also has more information on its use and file formats.
Thomas
Alun
A
Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, 84108, USA. alun@genepi.med.utah.edu
Camp
Nicola J
NJ
D005075:Biological Evolution; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D004252:DNA Mutational Analysis / Q000379:methods*; D005787:Gene Frequency / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population / Q000379:methods*; D016013:Likelihood Functions; D008957:Models, Genetic; D015233:Models, Statistical; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011381:Programming Languages; D012107:Research Design; D012984:Software