title: [Anxiodepressive and neuromediatory disorders in hypertensive patients. Effects of cypramil therapy].
abstract: OBJECTIVE
  To investigate psychic status and characteristics of neuromediatory metabolism in hypertensive patients, efficacy of antihypertensive therapy with lisinopril and hydrochlorthiaside with adjuvant citalopram (cipramil) which is a selective inhibitor of serotonin reuptake.
  
  
  METHODS
  Fifty patients with hypertension stage II (37 females, 13 males, mean age 48 years, mean duration of the disease 10.6 years) have undergone psychometric examination, estimation of evoked potentials P-300, 24-h monitoring of blood pressure. Plasma levels of epinephrine and norepinephrine, plasma and platelet levels of serotonin and 5-OIAA were measured at high-performance liquid chromatography.
  
  
  RESULTS
  Hypertensive patients were found to have high levels of depression, reactive and personality anxiety, subnormal quality of life. Blood pressure lowered more in patients given adjuvant cipramil.
  
  
  CONCLUSIONS
  Hypertensive patients have anxiodepressive disorders accompanied by monoamines disbolism. Cipramil effectively corrects these disorders.
authors.forename: A V
authors.initials: AV
authors.lastname: Nedostup
authors.forename: V I
authors.initials: VI
authors.lastname: Fedorova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Linevich
authors.forename: T G
authors.initials: TG
authors.lastname: Pukhal'skaia
authors.forename: G G
authors.initials: GG
authors.lastname: Toropina
authors.forename: V S
authors.initials: VS
authors.lastname: Kudrin
authors.forename: P M
authors.initials: PM
authors.lastname: Klodt
mesh_terms: D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001007:Anxiety / Q000150:complications / Q000188:drug therapy*; D015283:Citalopram / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000031:analogs & derivatives / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D017706:Lisinopril / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000959:Antihypertensive Agents; D015283:Citalopram; D006852:Hydrochlorothiazide; D017706:Lisinopril; D018377:Neurotransmitter Agents; D017367:Selective Serotonin Reuptake Inhibitors; C009732:buthiazide