title: Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS).
abstract: Autoimmune lymphoproliferative syndrome (ALPS) is associated with mutations that impair the activity of lymphocyte apoptosis proteins, leading to chronic lymphadenopathy, hepatosplenomegaly, autoimmunity, and an increased risk of lymphoma. We investigated the utility of fluorodeoxyglucose positron emission tomography (FDG-PET) in discriminating benign from malignant lymphadenopathy in ALPS. We report that FDG avidity of benign lymph nodes in ALPS can be high and, hence, by itself does not imply presence of lymphoma; but FDG-PET can help guide the decision for selecting which of many enlarged nodes in ALPS patients to biopsy when lymphoma is suspected.
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1888, USA.
authors.forename: V Koneti
authors.initials: VK
authors.lastname: Rao
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Carrasquillo
authors.forename: Janet K
authors.initials: JK
authors.lastname: Dale
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Bacharach
authors.forename: Millie
authors.initials: M
authors.lastname: Whatley
authors.forename: Faith
authors.initials: F
authors.lastname: Dugan
authors.forename: Jean
authors.initials: J
authors.lastname: Tretler
authors.forename: Thomas
authors.initials: T
authors.lastname: Fleisher
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Puck
authors.forename: Wyndham
authors.initials: W
authors.lastname: Wilson
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Jaffe
authors.forename: Nilo
authors.initials: N
authors.lastname: Avila
authors.forename: Clara C
authors.initials: CC
authors.lastname: Chen
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Straus
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D009154:Mutation; D049268:Positron-Emission Tomography / Q000379:methods* / Q000592:standards; D011446:Prospective Studies
chemical_list: D019788:Fluorodeoxyglucose F18