Capillary electrophoresis at the omics level: towards systems biology.
Emerging systems biology aims at integrating the enormous amount of existing omics data in order to better understand their functional relationships at a whole systems level. These huge datasets can be obtained through advances in high-throughput, sensitive, precise, and accurate analytical instrumentation and technological innovation. Separation sciences play an important role in revealing biological processes at various omic levels. From the perspective of systems biology, CE is a strong candidate for high-throughput, sensitive data generation which is capable of tackling the challenges in acquiring qualitative and quantitative knowledge through a system-level study. This review focuses on the applicability of CE to systems-based analytical data at the genomic, transcriptomic, proteomic, and metabolomic levels.
Babu C V
Suresh
S
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, Korea.
Song
Eun Joo
EJ
Babar
Sheikh Md Enayetul
SM
Wi
Mun Hyung
MH
Yoo
Young Sook
YS
D000818:Animals; D019075:Electrophoresis, Capillary; D023281:Genomics / Q000379:methods*; D006801:Humans; D010600:Pharmacology / Q000379:methods; D040901:Proteomics / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods