[Examination of the local antioxidative system of the eye in experimental corneal burn injury and the prospects for pharmacological correction of its parameters].
The present paper deals with the study of the efficiency of oral use of the antioxidative drug Immugen (a complex of alpha-tocopherol, oubichinone, selenium aspartate, methionine, and soyabean phospholipids) on a rabbit model of severe alkaline-induced corneal burn. The investigations have indicated that addition of Immugen to the rabbit feed exerts a significant positive effect on the parameters of the local antioxidative system of the eye and causes an increase in the activity of superoxide dismutase and catalase, and, on day 14, in antioxidative activity. The early experimental periods were marked by a slight rise in the frequency of deep corneal ulcerations. Moreover, the long-term clinical effect of use of Immugen appears as a significant increase in the area of the transparency-preserving affected cornea. The findings suggest that the antioxidants can show their optimal effect in the complex therapy for burn processes, including the use of proteinase inhibitors.
Makarov
P V
PV
Titkova
S M
SM
Anurov
M V
MV
Mikhal'chik
E V
EV
Chesnokova
N B
NB
Beznos
O V
OV
Stoliarova
E N
EN
Oganesian
O G
OG
Trofimova
M V
MV
Akopian
A V
AV
Kliuchikov
V Iu
VIu
Korkina
L G
LG
D000468:Alkalies / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D002057:Burns, Chemical / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D065306:Corneal Injuries; D016510:Corneal Neovascularization / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D005126:Eye Burns / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D005500:Follow-Up Studies; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism; D013666:Tears / Q000378:metabolism*; D016896:Treatment Outcome
D000468:Alkalies; D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase