title: Epstein-Barr virus-associated bronchial leiomyoma in a boy with cellular immunodeficiency.
abstract: Bronchial leiomyoma is a rare disease in children. Recently, the association of leiomyoma and HIV infection was reported. We describe a boy with a cellular immunodeficiency, who had endobronchial leiomyoma. The tumor cells were positive for Epstein-Barr virus-encoded RNA-1 (EBER-1) and Epstein-Barr virus-determined nuclear antigen-2, suggesting a role of Epstein-Barr virus in the pathogenesis of leiomyoma.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Hatano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takada
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nomura
authors.forename: Shouichi
authors.initials: S
authors.lastname: Ohga
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Isamu
authors.initials: I
authors.lastname: Saeki
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Tajiri
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Taguchi
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Suita
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D001984:Bronchial Neoplasms / Q000150:complications / Q000601:surgery / Q000821:virology*; D002648:Child; D003175:Complement C2 / Q000172:deficiency; D003186:Complement C9 / Q000172:deficiency; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007889:Leiomyoma / Q000150:complications / Q000601:surgery / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000032:analysis*; D014412:Tumor Virus Infections / Q000235:genetics
chemical_list: D003175:Complement C2; D003186:Complement C9; D019309:Epstein-Barr Virus Nuclear Antigens; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral