title: [Strategies targeted at optimising antimicrobial therapy in critically ill patients].
abstract: Antibiotics are widely used in critical care and adequate empirical treatments has a significant impact on the outcome of many patients. Most nosocomial infections may be due to multidrug-resistant pathogens and requires empirical borad spectrum coverage before identification of the etiologic agents. This is associated with overuse of antibiotics which contributes to the further increase in multidrug-resistances. In this context, new strategies targeted at antibiotic control, such as guidelines and de-escalation are needed to control this evolution.
authors.affiliation: Soins intensifs de chirurgie, Département de chirurgie, CHUV, Lausanne. philippe.eggimann@chuv.ch
authors.forename: Philippe
authors.initials: P
authors.lastname: Eggimann
authors.forename: Mauro
authors.initials: M
authors.lastname: Oddo
authors.forename: Pierre
authors.initials: P
authors.lastname: Voirol
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zanetti
authors.forename: René
authors.initials: R
authors.lastname: Chioléro
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016638:Critical Illness; D003428:Cross Infection / Q000517:prevention & control*; D004352:Drug Resistance, Microbial; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents