title: Standard and experimental therapy in cutaneous T-cell lymphomas.
abstract: Cutaneous T-cell lymphomas are a heterogeneous group of lymphoproliferative disorders, characterized by the accumulation of clonal lymphocytes in the skin. Skin-directed therapies are the preferred first-line modalities. There are interesting new developments in topical therapy using retinoids and gene-therapy products such as adenovirus- interferon (IFN)-gamma. Systemic treatment uses biologicals such as fusion molecules, monoclonal antibodies and immune response modifiers (IFNs and retinoids), and well-tolerated antiproliferative drugs such as methotrexate. Evidence-based treatment recommendation exists but is hampered by the lack of large multicenter randomized trials.
authors.affiliation: Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland. reinhard.dummer@usz.ch
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dummer
authors.forename: Antonio
authors.initials: A
authors.lastname: Cozzio
authors.forename: Sibylle
authors.initials: S
authors.lastname: Meier
authors.forename: Mirjam
authors.initials: M
authors.lastname: Beyeler
authors.forename: Barbara
authors.initials: B
authors.lastname: Laetsch
authors.forename: Udo
authors.initials: U
authors.lastname: Doebbeling
authors.forename: Mirjana
authors.initials: M
authors.lastname: Urosevic
mesh_terms: D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology / Q000628:therapy*; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*