title: Subcutaneous panniculitis-like T-cell lymphoma misdiagnosed as lupus erythematosus panniculitis.
abstract: We report a case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL), associated with macrophage activation syndrome, mimicking a lupus erythematosus panniculitis (LEP). A 29-year-old woman presented with high fever, general malaise, nausea, vomiting, and subcutaneous nodules and ulcerating lesions located on the lower extremities. The histopathology showed an infiltration of the panniculus, mostly involving fat, and periadnexial and perivascular structures consistent with lymphocytic lobular panniculitis (LLP). LLP is a shared feature of LEP and SPTCL. The immunophenotyping of the cell infiltrate was crucial for a correct diagnosis.
authors.affiliation: Section of Rheumatology, Clinical Medicine and Immunological Science, University of Siena, Siena, Italy. estrellagarcia@hotmail.com
authors.forename: Estrella Garcia
authors.initials: EG
authors.lastname: Gonzalez
authors.forename: Enrico
authors.initials: E
authors.lastname: Selvi
authors.forename: Sauro
authors.initials: S
authors.lastname: Lorenzini
authors.forename: Roberta
authors.initials: R
authors.lastname: Maggio
authors.forename: Susanna
authors.initials: S
authors.lastname: Mannucci
authors.forename: Mauro
authors.initials: M
authors.lastname: Galeazzi
authors.forename: Roberto
authors.initials: R
authors.lastname: Marcolongo
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D009102:Multiple Organ Failure; D015434:Panniculitis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D015435:Panniculitis, Lupus Erythematosus / Q000175:diagnosis*; D040521:Subcutaneous Tissue / Q000276:immunology / Q000473:pathology*; D013577:Syndrome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide