Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS.
The authors calculated the progression rate (DeltaFS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the DeltaFS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the DeltaFS provides an additional predictive index beyond ALSFRS-R alone.
Kimura
F
F
Division of Neurology, First Department of Internal Medicine, Osaka Medical College, Osaka, Japan. in1110@poh.osaka-med.ac.jp
Fujimura
C
C
Ishida
S
S
Nakajima
H
H
Furutama
D
D
Uehara
H
H
Shinoda
K
K
Sugino
M
M
Hanafusa
T
T
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000401:mortality* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008136:Longevity; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012720:Severity of Illness Index