Normalization in quantitative [18F]FDG PET imaging: the 'body surface area' may be a volume.
Non-invasive methods for quantifying [(18)F]FDG uptake in tumours often require normalization to either body weight or body surface area (BSA), as a surrogate for [(18)F]FDG distribution volume (DV). Whereas three dimensions are involved in DV and weight (assuming that weight is proportional to volume), only two dimensions are obviously involved in BSA. However, a fractal geometry interpretation, related to an allometric scaling, suggests that the so-called 'body surface area' may stand for DV.
Laffon
Eric
E
CHU de Bordeaux, Hôpital du Haut-Lévêque, Service de Médecine Nucléaire, F-33076, Bordeaux, France. elaffon@u-bordeaux2.fr
Suárez
Kleydis
K
Berthoumieu
Yannick
Y
Ducassou
Dominique
D
Marthan
Roger
R
D055592:Biophysical Phenomena; D001703:Biophysics; D001830:Body Surface Area; D001835:Body Weight; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry*; D017709:Fractals; D006801:Humans; D008962:Models, Theoretical; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000494:pharmacology
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18