Pharmacological evaluation of newly synthesized piperidinium derivatives for their analgesic activity.
Two chemically synthesized piperidinium derivatives i.e l-methyl-1-(3,4) dihydroxy phenacyl-4-hydroxy piperidinium chloride and 1-methyl-(4-p) methoxy phenacyl 4-hydroxy piperidinium bromide have been evaluated for their analgesic activity in intact albino mice by tail immersion method because of their structural similarity with opioids. Both the compounds were administered in the doses of 50 mg/kg. The results were compared with pethidine used as the reference drug. The control animal received only the vehicle. The present study suggested that both the compounds exhibit significant analgesic activity.
Khan
R A
RA
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Rasheed
H
H
Saify
Z S
ZS
Rehman
A B
AB
Arif
M
M