Immunotherapy for fungal infections.
Opportunistic fungal infections are major causes of morbidity and mortality among immunocompromised individuals. Fungi have evolved complex and coordinated mechanisms to survive in the environment and in the mammalian host. Fungi must adapt to "stressors" in the host (including scarcity of nutrients, pH, and reactive oxygen and nitrogen intermediates) in addition to evading host immunity. Knowledge of the immunopathogenesis of fungal infections has paved the way to promising strategies for immunotherapy. These include strategies that increase phagocyte number, activate innate host defense pathways in phagocytes and dendritic cells, and stimulate antigen-specific immunity (e.g., vaccines). Immunotherapy must be tailored to specific immunocompromised states. Challenges exist in bringing promising immunotherapies from the laboratory to clinical trials.
Segal
Brahm H
BH
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. brahm.segal@roswellpark.org
Kwon-Chung
June
J
Walsh
Thomas J
TJ
Klein
Bruce S
BS
Battiwalla
Minoo
M
Almyroudis
Nikolaos G
NG
Holland
Steven M
SM
Romani
Luigina
L
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000906:Antibodies / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000276:immunology; D002986:Clinical Trials as Topic; D003115:Colony-Stimulating Factors / Q000627:therapeutic use; D005657:Fungal Vaccines / Q000008:administration & dosage; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D007371:Interferon-gamma / Q000627:therapeutic use; D017708:Leukocyte Transfusion; D009181:Mycoses / Q000150:complications / Q000276:immunology* / Q000628:therapy*; D009503:Neutropenia / Q000150:complications / Q000628:therapy; D009894:Opportunistic Infections / Q000276:immunology; D011994:Recombinant Proteins; D000683:Serum Amyloid P-Component / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology; D000099153:Pentraxins
D000276:Adjuvants, Immunologic; D000906:Antibodies; D002097:C-Reactive Protein; D003115:Colony-Stimulating Factors; D005657:Fungal Vaccines; D007371:Interferon-gamma; D011994:Recombinant Proteins; D000683:Serum Amyloid P-Component; D051193:Toll-Like Receptors; D000099153:Pentraxins