title: Isochromosome 7q in Down syndrome.
abstract: Isochromosome 7q is not an uncommon chromosomal abnormality. It has been reported in association with Shwachman-Diamond syndrome, Wilms tumor, and hepatosplenic T-cell lymphoma. In other hematolymphoid malignancies, it occurs almost invariably as a secondary change. A notable example is its association with t(4;11)(q21;q23) in acute lymphoblastic leukemia. It has rarely been described in myelodysplastic syndrome and acute myeloid leukemia. We report the occurrence of i(7q) as the primary abnormality in a 2-year-old boy with Down syndrome and minimally differentiated acute myeloid leukemia.
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong SAR, China. kfwong@ha.org.hk
authors.forename: K F
authors.initials: KF
authors.lastname: Wong
authors.forename: S C
authors.initials: SC
authors.lastname: Lam
authors.forename: Jennifer N S
authors.initials: JN
authors.lastname: Leung
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001854:Bone Marrow Cells / Q000473:pathology; D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7; D004314:Down Syndrome / Q000235:genetics*; D006801:Humans; D007223:Infant; D018404:Isochromosomes; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male