title: Proteomic analysis of pathogenic bacterium Vibrio vulnificus.
abstract: In this study we have constructed a proteome reference map of the pathogenic bacterium Vibrio vulnificus. From the reference map, we identified several virulence-related proteins, such as ToxR and ToxS, as well as numerous proteins involved in diverse cellular functions. To search for additional virulence-related proteins, we compared the whole proteomes from the wild-type and toxR mutant of V. vulnificus and found that several proteins were up- or down-regulated in the toxR mutant. We suggest that these differentially regulated proteins whose expression is coordinately controlled by a virulence regulator ToxR, some of which are already implicated in virulence, play roles in the pathogenesis of V. vulnificus.
authors.affiliation: Systemic Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, Korea.
authors.forename: Ah Young
authors.initials: AY
authors.lastname: Lee
authors.forename: Sung Goo
authors.initials: SG
authors.lastname: Park
authors.forename: Mi
authors.initials: M
authors.lastname: Jang
authors.forename: Sayeon
authors.initials: S
authors.lastname: Cho
authors.forename: Pyung Keun
authors.initials: PK
authors.lastname: Myung
authors.forename: Young Ran
authors.initials: YR
authors.lastname: Kim
authors.forename: Joon Haeng
authors.initials: JH
authors.lastname: Rhee
authors.forename: Do Hee
authors.initials: DH
authors.lastname: Lee
authors.forename: Byoung Chul
authors.initials: BC
authors.lastname: Park
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism*; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000235:genetics / Q000494:pharmacology*; D015180:Electrophoresis, Gel, Two-Dimensional; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014157:Transcription Factors / Q000235:genetics / Q000494:pharmacology*; D041261:Vibrio vulnificus / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D015415:Biomarkers; D004268:DNA-Binding Proteins; D020543:Proteome; D014157:Transcription Factors; C066719:toxR protein, bacteria