Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2.
Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively.
Heesen
Michael
M
Department of Anesthesia, Bamberg Hospital and University Hospital Aachen, Bamberg, Germany. michael.heesen@sozialstiftung-bamberg.de
Renckens
Rosemarijn
R
de Vos
Alex F
AF
Kunz
Dagmar
D
van der Poll
Tom
T
D000293:Adolescent; D000328:Adult; D054410:Chemokine CCL7; D015536:Down-Regulation; D019446:Endotoxemia / Q000139:chemically induced / Q000378:metabolism*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D018945:Monocyte Chemoattractant Proteins / Q000378:metabolism; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
C515450:CCL7 protein, human; C515334:CCR2 protein, human; D054410:Chemokine CCL7; D008070:Lipopolysaccharides; D018945:Monocyte Chemoattractant Proteins; D054390:Receptors, CCR2; D019707:Receptors, Chemokine; D014409:Tumor Necrosis Factor-alpha