title: Predictors of intracytoplasmic sperm injection (ICSI) outcome in couples with and without male factor infertility.
abstract: OBJECTIVE
  To find out the predictors of ICSI outcome.
  
  
  METHODS
  Forty-three pregnancies in 100 consecutive ICSI cycles.
  
  
  RESULTS
  Every 1,000 pg/ml increase in hCG-day E2 (OR = 0.46, CI: 0.25-0.83, p = 0.01) and 1% decrease in the rate of normal sperm morphology (OR = 0.81, CI: 0.67-0.98, p = 0.03) caused a significant decrease in clinical pregnancy rate and live birth rate (respectively, OR = 0.5, CI: 0.32-0.96, p = 0.03, OR = 0.66, CI: 0.5-0.86, p = 0.002) while every increase in the number of good quality embryos transferred caused a two-time increase in the clinical pregnancy rate (OR = 2.1, CI: 1.2-4, p = 0.01). On the other hand, every increase in the number of four-cell cleavage embryos (OR = 1.02, CI: 1.002-1.04, p = 0.03) and hCG-day endometrial thickness (OR = 1.6, CI: 1.15-2.24, p = 0.005) were found to increase the live birth rate. Implantation rate (m = 8.3 +/- 14.6) was significantly lower in cases with leucocytospermia (n = 33) compared to cases without leucocytospermia (n = 67, m = 17.4 +/- 24.6, p = 0.02).
  
  
  CONCLUSIONS
  Leucocytospermia, hCG-day E2 level and endometrial thickness, normal sperm morphology, and number of good quality embryos are predictors of implantation, clinical pregnancy and live birth rate following ICSI.
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Vural
authors.forename: K
authors.initials: K
authors.lastname: Sofuoglu
authors.forename: E
authors.initials: E
authors.lastname: Caliskan
authors.forename: N
authors.initials: N
authors.lastname: Delikara
authors.forename: E
authors.initials: E
authors.lastname: Aksoy
authors.forename: H
authors.initials: H
authors.lastname: Uslu
authors.forename: A
authors.initials: A
authors.lastname: Karan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002970:Cleavage Stage, Ovum; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000033:anatomy & histology; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012044:Regression Analysis; D012661:Semen / Q000166:cytology; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods / Q000592:standards*; D013081:Sperm Motility; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004967:Estrogens