title: Memory activation enhances EEG abnormality in mild cognitive impairment.
abstract: This exploratory study investigated EEG power changes during memory activation in patients with amnestic mild cognitive impairment (MCI). Twelve MCI patients and 16 age-matched controls underwent EEG registration during two conventional EEG conditions ('eyes closed' and 'eyes open') and three memory conditions ('word memory', 'picture memory' and 'animal fluency'). For all conditions, EEG power in the theta (4-8 Hz), lower alpha (8-10.5 Hz) and upper alpha (10.5-13 Hz) bands were expressed as percentile changes compared to 'eyes closed'. MCI patients showed significantly less decrease in the lower alpha band than controls (p=0.04) during picture memory activation. The word memory task showed a trend towards a similar effect (p=0.09). This study suggests that memory activation reveals EEG differences between MCI patients and controls while conventional EEG conditions do not.
authors.affiliation: Department of Neurology J3R, Clinical Neurophysiology and Neuropsychology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. K.van_der_Hiele@lumc.nl
authors.forename: K
authors.initials: K
authors.lastname: van der Hiele
authors.forename: A A
authors.initials: AA
authors.lastname: Vein
authors.forename: C G S
authors.initials: CG
authors.lastname: Kramer
authors.forename: R H A M
authors.initials: RH
authors.lastname: Reijntjes
authors.forename: M A
authors.initials: MA
authors.lastname: van Buchem
authors.forename: R G J
authors.initials: RG
authors.lastname: Westendorp
authors.forename: E L E M
authors.initials: EL
authors.lastname: Bollen
authors.forename: J G
authors.initials: JG
authors.lastname: van Dijk
authors.forename: H A M
authors.initials: HA
authors.lastname: Middelkoop
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology*; D010364:Pattern Recognition, Visual