title: Crohn's disease in people exposed to clinical cases of bovine paratuberculosis.
abstract: Mycobacterium avium subspecies paratuberculosis (Map), the cause of ruminant paratuberculosis, has been proposed as the causative agent of Crohn's disease. The objective of this study was to determine whether exposure to clinical cases of bovine paratuberculosis was a risk factor for Crohn's disease. A questionnaire was sent to dairy farmers living on premises where the occurrence or absence of clinical cases of bovine paratuberculosis had previously been determined. The prevalence of Crohn's disease was found to be similar to that reported in other studies in the United Kingdom and showed no association with bovine paratuberculosis. There was, however, a univariate association with geographical region. Ulcerative colitis showed univariate associations with age, frequency of contact with cattle and with smoking. The results do not support the hypothesis that Map plays a causative role in the aetiology of Crohn's disease.
authors.affiliation: Division of Farm Animal Science, School of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol, UK. p.h.jones@bris.ac.uk
authors.forename: P H
authors.initials: PH
authors.lastname: Jones
authors.forename: T B
authors.initials: TB
authors.lastname: Farver
authors.forename: B
authors.initials: B
authors.lastname: Beaman
authors.forename: B
authors.initials: B
authors.lastname: Cetinkaya
authors.forename: K L
authors.initials: KL
authors.lastname: Morgan
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D003424:Crohn Disease / Q000453:epidemiology* / Q000209:etiology*; D003612:Dairying; D003625:Data Collection; D004781:Environmental Exposure; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016927:Mycobacterium avium subsp. paratuberculosis / Q000472:pathogenicity; D010283:Paratuberculosis / Q000150:complications*; D015995:Prevalence; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology