title: Are blood cultures necessary in the management of women with complicated pyelonephritis?
abstract: OBJECTIVE
  Data from previous studies suggest that blood cultures in women with uncomplicated acute pyelonephritis (APN) are of limited value. Our objective was to assess the role of blood cultures in the management of complicated APN in women, and to examine the demographic and clinical characteristics, and the outcome as related to the bacteremic status of these patients.
  
  
  METHODS
  Data from medical records of 158 women hospitalized with complicated APN over a 2-year period were analyzed retrospectively. It included demographic, clinical and laboratory data, details of the empiric antimicrobial therapy, urine and blood culture results, complications and clinical outcome.
  
  
  RESULTS
  Out of 158 women with complicated APN, in 155 (98%) pathogens grew in the urine culture, and 33 (20.9%) of them had bacteremia. In the great majority of patients (98.7%), the blood cultures were sterile, or contained the same phenotypically profiled pathogen that was isolated from the urine. Only in two patients (1.3%), the blood cultures grew pathogens different from those found in the urine. The initial empiric antimicrobial therapy was not changed in any of the patients. No significant difference existed between the bacteremic and nonbacteremic patients in the demographic and clinical characteristics, the severity of disease or the outcome.
  
  
  CONCLUSIONS
  In the management of complicated APN, routine cultures of blood should be reevaluated.
authors.affiliation: Infectious Diseases Unit, Ha'emek Medical Center, Afula 18101, Israel. chen_ya@clalit.org.il
authors.forename: Yael
authors.initials: Y
authors.lastname: Chen
authors.forename: Orna
authors.initials: O
authors.lastname: Nitzan
authors.forename: Walid
authors.initials: W
authors.lastname: Saliba
authors.forename: Bibiana
authors.initials: B
authors.lastname: Chazan
authors.forename: Raul
authors.initials: R
authors.lastname: Colodner
authors.forename: Raul
authors.initials: R
authors.lastname: Raz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D001431:Bacteriological Techniques; D001769:Blood / Q000382:microbiology*; D003470:Culture Media; D005260:Female; D006801:Humans; D008875:Middle Aged; D011704:Pyelonephritis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology; D014556:Urine / Q000382:microbiology
chemical_list: D003470:Culture Media