Toxicity and anticoagulant activity of Salvia splendens.
Toxicological studies carried out on aqueous extract of Salvia splendens commonly known as Red Sage reveals that the drug is toxic only in higher doses and causes hemorrhages. LD50 of S. splendens is 1287.3 mg/Kg. Salvia splendens possesses anticoagulant property. The aqueous root extract of Salvia splendens increases the clotting time of dog's plasma by increasing the normal prothrombin time from 10-15 seconds to 35 seconds. Furthermore, the anticoagulant activity depends upon the part of the plant i.e. flowers, aerial parts and roots.
Qureshi
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Pharmaceutical and Fine Chemical Division, P.C.S.I.R. Laboratory, Karachi-39, Pakistan.
Ahmad
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Kapadia
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