title: Effect of bicarbonated Ringer's solution on the acid-base balance in patients undergoing abdominal aortic aneurysm repair.
abstract: OBJECTIVE
  The present study was designed to assess whether prophylactic use of bicarbonated Ringer's solution ameliorates metabolic acidosis in patients undergoing aortic surgery.
  
  
  METHODS
  Twenty patients undergoing elective infrarenal aortic aneurysm repair were randomly assigned to receive either bicarbonated Ringer's solution or acetated Ringer's solution. The pH, PaCO(2), and base excess (BE) were measured before surgical incision (T0), 5 min before reperfusion (T1), 5 min after reperfusion (T2), and 30 min after reperfusion (T3). Data were compared between the two groups.
  
  
  RESULTS
  Both pH and BE initially showed a slight decrease in both groups during clamping. After unclamping of the aorta, an additional decrease in pH was observed in both groups (T0 to T2, and T3). There were no significant differences in pH between the groups throughout the study period.
  
  
  CONCLUSIONS
  Aortic cross-clamping leads to the development of metabolic acidosis, with a decrease in pH and BE. The effect of administration of bicarbonated infusion fluid during elective abdominal aortic surgery had not significant compared with that of acetated Ringer's solution with respect to acid-base homeostasis.
authors.affiliation: Department of Anesthesiology, Nippon Medical School Second Hospital, Kanagawa, Japan. megu@nms.ac.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Shimada
authors.forename: Akira
authors.initials: A
authors.lastname: Kitamura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Hongo
authors.forename: Chol
authors.initials: C
authors.lastname: Kim
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Sakamoto
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000138:Acidosis / Q000517:prevention & control; D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D007552:Isotonic Solutions; C028570:Ringer's acetate; C506920:bicarbonated Ringer's solution