title: Uncertainty of the thyroid dose conversion factor for inhalation intakes of 131I and its parametric uncertainty.
abstract: Inhalation exposures of 131I may occur in the physical form of a gas as well as a particulate. The physical characteristics pertaining to these different types of releases influence the intake and subsequent dose to an exposed individual. The thyroid dose received is influenced by the route through which 131I enters the body and its subsequent clearance, absorption and movement throughout the body. The radioactive iodine taken up in the gas-exchange tissues is cleared to other tissues or absorbed into the bloodstream of the individual and transferred to other organs. Iodine in the circulatory system is then taken up by the thyroid gland with resulting dose to that tissue. The magnitude of and uncertainty in the thyroid dose is important to the assessment of individuals exposed to airborne releases of radioiodine. Age- and gender-specific modelling parameters have resulted in significant differences between gas uptake, particulate deposition and inhalation dose conversion factors for each age and gender group. Inhalation dose conversion factors and their inherent uncertainty are markedly affected by the type of iodine intake. These differences are expected due to the modelling of particulate deposition versus uptake of gas in the respiratory tract. Inhalation dose estimates via iodine gases are very similar and separate classifications may not be necessarily based on this assessment.
authors.affiliation: Radiation Safety Department, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Richard.Harvey@RoswellPark.org
authors.forename: R P
authors.initials: RP
authors.lastname: Harvey
authors.forename: D M
authors.initials: DM
authors.lastname: Hamby
authors.forename: T S
authors.initials: TS
authors.lastname: Palmer
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D015233:Models, Statistical; D009928:Organ Specificity; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013961:Thyroid Gland / Q000378:metabolism*; D014481:United States / Q000453:epidemiology
chemical_list: D007457:Iodine Radioisotopes