title: Disruption of the SLC26A3-mediated anion transport is associated with male subfertility.
abstract: Male subfertility in congenital chloride diarrhea (CLD) was possible after identification of expression of an epithelial Cl-/HCO3- exchanger SLC26A3 in the male reproductive tract and by the observation that adult men with CLD had very few children. A prospective clinical and laboratory study among eight adult Finnish men with CLD revealed constant oligoasthenoteratozoospermia but normal spermatogenesis, high chloride and low pH in seminal plasma, and three spermatoceles, suggesting that male subfertility is a clinical manifestation of CLD and could be caused by an analogous defect in the epithelial Cl-/HCO3- and water transport, as described for the CLD intestine.
authors.affiliation: Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. Pia.Hoglund@Helsinki.Fi
authors.forename: Pia
authors.initials: P
authors.lastname: Höglund
authors.forename: Satu
authors.initials: S
authors.lastname: Hihnala
authors.forename: Minna
authors.initials: M
authors.lastname: Kujala
authors.forename: Aila
authors.initials: A
authors.lastname: Tiitinen
authors.forename: Leo
authors.initials: L
authors.lastname: Dunkel
authors.forename: Christer
authors.initials: C
authors.lastname: Holmberg
mesh_terms: D000293:Adolescent; D000328:Adult; D017920:Antiporters / Q000235:genetics* / Q000378:metabolism*; D001639:Bicarbonates / Q000378:metabolism; D027963:Chloride-Bicarbonate Antiporters; D002712:Chlorides / Q000378:metabolism; D003967:Diarrhea / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D012661:Semen / Q000378:metabolism; D000076988:Sulfate Transporters; D014883:Water-Electrolyte Imbalance / Q000235:genetics / Q000378:metabolism
chemical_list: D017920:Antiporters; D001639:Bicarbonates; D027963:Chloride-Bicarbonate Antiporters; D002712:Chlorides; C081011:SLC26A3 protein, human; D000076988:Sulfate Transporters