title: Effect of nonabsorbed amounts of a fructose-sorbitol mixture on small intestinal transit in healthy volunteers.
abstract: Although malabsorption of small amounts of fructose-sorbitol mixtures occurs frequently in healthy humans, insights into their effects on gastrointestinal motility are poor. The present study addresses the hypothesis that malabsorption of a fructose-sorbitol challenge changes the small intestinal transit rate. Eleven healthy volunteers participated in a double-blind crossover investigation. In random order, the subjects ingested 30 g glucose or a mixture of 25 g fructose and 5 g sorbitol as 10% solutions. As a radiolabeled marker, (99m)Tc-diethylenetriaminepentaacetic acid was added to each test solution. Breath hydrogen and methane concentrations and gastrointestinal progress of the radiolabeled marker were followed for the next 6-hr period. Malabsorption of small amounts of the fructose-sorbitol mixture was evident in all subjects. The area under the gastric radioactivity-time curve after ingestion of glucose did not differ from that after ingestion of the fructose-sorbitol mixture (P = 0.7897). However, the mouth-to-cecum transit of the radiolabeled marker was faster (P = 0.0033) and the percentage content of the marker in colon was higher after ingestion of the fructose-sorbitol mixture than after ingestion of glucose (P = 0.0128). In healthy humans, malabsorption of small amounts of a fructose-sorbitol mixture accelerates small bowel transit.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Copenhagen, Denmark. jan.lysgaard.madsen@ hh.hosp.dk
authors.forename: Jan L
authors.initials: JL
authors.lastname: Madsen
authors.forename: Jan
authors.initials: J
authors.lastname: Linnet
authors.forename: Jüri J
authors.initials: JJ
authors.lastname: Rumessen
mesh_terms: D000328:Adult; D001944:Breath Tests; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005632:Fructose / Q000008:administration & dosage*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000502:physiology*; D008286:Malabsorption Syndromes / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012016:Reference Values; D013012:Sorbitol / Q000008:administration & dosage*; D013549:Sweetening Agents / Q000008:administration & dosage*; D016284:Technetium Tc 99m Pentetate
chemical_list: D004338:Drug Combinations; D019275:Radiopharmaceuticals; D013549:Sweetening Agents; D005632:Fructose; D013012:Sorbitol; D016284:Technetium Tc 99m Pentetate