Effects of meloxicam on renal function in dogs with hypotension during anaesthesia.
OBJECTIVE
To evaluate the effects of meloxicam on renal function in dogs anaesthetized and rendered hypotensive with acepromazine-thiopental-isoflurane.


METHODS
Eight healthy beagles, four males and four females, 25.6 +/- 19.3 months old and weighing 12.8 +/- 2.0 kg.


METHODS
Either meloxicam suspension at a dose of 0.133 mL kg(-1) (0.2 mg kg(-1)) or 0.133 mL kg(-1) saline solution (control), were given by mouth (PO) in a randomized, cross-over fashion. The treatment or control was given 3 hours before anaesthesia. Dogs were sedated with intramuscular acepromazine 0.1 mg kg(-1). Anaesthesia was induced with intravenous thiopental, followed by tracheal intubation and maintenance with isoflurane in oxygen and air, delivered using a semi-closed breathing system. Renal function was quantified using serum biochemistry, urinalysis and glomerular filtration rate measured by scintigraphy. Analysis of variance or Friedman anova were used for statistical analysis.


RESULTS
Values (mean +/- SD) for mean arterial blood pressure did not differ significantly between treatments but was low (54 +/- 7 mmHg) during anaesthesia. Glomerular filtration rate did not differ significantly between treatments or over time, and results of urine and serum analysis were within reference ranges after meloxicam treatment.


CONCLUSIONS
Meloxicam caused no adverse effects on renal function when given to healthy dogs anaesthetized and rendered hypotensive with acepromazine, thiopental and isoflurane.
Boström
Ingrid M
IM
Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden. i.bostrum@spray.se
Nyman
Görel
G
Hoppe
Astrid
A
Lord
Peter
P
D000075:Acepromazine / Q000494:pharmacology; D000418:Albumins / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000768:Anesthesia, General / Q000009:adverse effects / Q000662:veterinary*; D000818:Animals; D001798:Blood Proteins; D018592:Cross-Over Studies; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary*; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology*; D007530:Isoflurane / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D008297:Male; D000077239:Meloxicam; D013843:Thiazines / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D013844:Thiazoles / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology
D000418:Albumins; D018712:Analgesics, Non-Narcotic; D001798:Blood Proteins; D013843:Thiazines; D013844:Thiazoles; D000075:Acepromazine; D007530:Isoflurane; D013874:Thiopental; D000077239:Meloxicam