title: Salmonella enterica serovar Typhimurium ompS1 and ompS2 mutants are attenuated for virulence in mice.
abstract: Salmonella enterica serovar Typhimurium mutants with mutations in the ompS1 and ompS2 genes, which code for quiescent porins, were nevertheless highly attenuated for virulence in a mouse model, indicating a role in pathogenesis. Similarly, a strain with a mutation in the gene coding for LeuO, a positive regulator of ompS2, was also attenuated.
authors.affiliation: Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, México.
authors.forename: Olivia
authors.initials: O
authors.lastname: Rodríguez-Morales
authors.forename: Marcos
authors.initials: M
authors.lastname: Fernández-Mora
authors.forename: Ismael
authors.initials: I
authors.lastname: Hernández-Lucas
authors.forename: Alejandra
authors.initials: A
authors.lastname: Vázquez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Puente
authors.forename: Edmundo
authors.initials: E
authors.lastname: Calva
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D012481:Salmonella Infections, Animal / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014774:Virulence
chemical_list: D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; C430340:LeuO protein, E coli; D014157:Transcription Factors