Effects of cinchocaine cocaine analogs on brain mono amines and their metabolites in male mice.
Cinchocaine analogs were studied to determine the effects of acute administration of cocaine analogs on dopamine, 5- hydroxytryptamine (5-HT) and their metabolites. Psychomotor stimulants, (such as cinchocaine), potently influencing dopamine transport carrier were used to characterize in-vivo DA transmission. DA, DOPAC, HVA level and indoleamine were measured in brain after drug administration. Significant changes in levels of DA, DOPAC, 5-HT, 5HIAA and HVA were noted. The present findings suggests that acute administration of cinchocaine increases the level of Dopamine, 5-HT and their metabolites and alter the level of amines as compare to control group. These studies also indicate that difference in structure do not affect the binding sites and inhibition of amine uptake.
Naqvi
S T
ST
Department of Pharmacology, University of Karachi, Karachi-75270, Pakistan.
Ahmed
S P
SP
Najam
R
R
Haider
S
S
Zuberi
M S
MS
Haleem
D J
DJ