[Effects of recipe for invigorating kidney on expression of estrogen receptors in ovariectomized rats].
OBJECTIVE
To observe the effects of recipe for invigorating kidney on expression of estrogen receptors in ovariectomized rats.


METHODS
The rats, which were given high-cholesterol diet after ovariectomy, were chosen as experimental subjects. After fed kidney-invigorating recipe for 16 weeks, the rats were killed and the levels of serum lipid and estradiol of these rats were examined. The expressions of estrogen receptor alpha and beta mRNAs in aorta, pituitary gland and hypothalamus, and the affinity of estrogen receptor-ligand were also detected.


RESULTS
The kidney-invigorating recipe could increase the expression levels of estrogen receptor alpha and beta mRNAs in different parts such as aorta, pituitary gland and hypothalamus, and enhance the affinity of estrogen receptor-ligands.


CONCLUSIONS
The recipe for invigorating kidney may meliorate atherosclerosis in ovariectomized rats by regulating the estrogen receptors.
Yang
Wen-Bin
WB
Institute of Integrative Medicine, Fudan University, Shanghai 200040, China.
Wang
Wen-Jian
WJ
Fei
Zhen-Yu
ZY
D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D010052:Ovariectomy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000096:biosynthesis* / Q000235:genetics
D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D004958:Estradiol