title: Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects.
abstract: OBJECTIVE
  The aim of our work is to evaluate the efficacy of intracavernous sodium nitroprusside (SNP) in management of erectile dysfunction (ED) in a clinical comparative study with papaverine/phentolamine in ED patients.
  
  
  METHODS
  The study included 40 patients with ED divided into two groups. Group I include 20 patients receiving intracavernous (30 mg papaverine + 1 mg phentolamine) followed 1 week later by intracavernous 300 microg SNP. Group II included 20 patients receiving the same regimen of group I but with intracavernous SNP first followed by papaverine/phentolamine 1 week later. All patients were assessed clinically for their response and any developing complications.
  
  
  RESULTS
  The numbers of good and poor responders were not statistically significant (P > 0.05) among the two groups. The mean erectile duration of SNP was similar to bimix (P > 0.05). No side-effects whether local or systemic occurred with SNP while priapism and local penile pain were recorded with bimix solution.
  
  
  CONCLUSIONS
  Intracavernous pharmacotherapy is still a reliable method both for diagnosis and for treatment of ED. While preliminary results of our study show a potential of SNP to be an effective and safe intracavernous agent, long-term self-injection clinical trials are needed before large-scale usage is recommended.
authors.affiliation: Department of Andrology Sexology and STDs, Cairo University, Egypt. rannone74@hotmail.com
authors.forename: Rany
authors.initials: R
authors.lastname: Shamloul
authors.forename: Ahmed
authors.initials: A
authors.lastname: Atteya
authors.forename: Abdelrahman
authors.initials: A
authors.lastname: Elnashaar
authors.forename: Amr
authors.initials: A
authors.lastname: Gadallah
authors.forename: Wael
authors.initials: W
authors.lastname: Zohdy
authors.forename: Wael
authors.initials: W
authors.lastname: Abdelsalam
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008297:Male; D009599:Nitroprusside / Q000009:adverse effects / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced; D010208:Papaverine / Q000009:adverse effects / Q000627:therapeutic use; D010646:Phentolamine / Q000009:adverse effects / Q000627:therapeutic use; D011317:Priapism / Q000139:chemically induced; D018709:Statistics, Nonparametric; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000317:Adrenergic alpha-Antagonists; D014665:Vasodilator Agents; D009599:Nitroprusside; D010208:Papaverine; D010646:Phentolamine