The role of matrix metalloproteinase 9 in early neurological worsening of acute lacunar infarction.
The involvement of matrix metalloproteinases (MMPs) in ischemic-stroke-induced inflammatory response has recently been suggested; however, the relationship between MMPs and stroke progression has not been evaluated. We investigated the role of MMPs in neurological worsening of acute lacunar infarction. Forty-nine consecutive patients with an acute lacunar infarction (as defined by clinical and MRI criteria within 48 h after stroke onset) were evaluated. Clinical, biochemical, rheological, inflammatory and other parameters were compared between progressive and nonprogressive groups. Among the variables, only inflammatory parameters, including MMP-9 and erythrocyte sedimentation rate, were associated with neurological worsening of acute lacunar infarction (p<0.05). These results suggest that the inflammatory process could play an important role in early neurological worsening of acute lacunar infarction.
Kim
Young Seo
YS
Department of Neurology, College of Medicine, Hanyang University, Seoul, South Korea.
Lee
Kyu-Yong
KY
Koh
Seong-Ho
SH
Park
Chang Yun
CY
Kim
Hyun Young
HY
Lee
Young Joo
YJ
Kim
Hee Tae
HT
Kim
Juhan
J
Kim
Myung-Ho
MH
Kim
Kyung Suk
KS
Chang
Dae-il
DI
Kim
Seung Hyun
SH
D000208:Acute Disease; D000368:Aged; D001799:Blood Sedimentation; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D020520:Brain Infarction / Q000175:diagnosis / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000502:physiology*; D008875:Middle Aged; D009460:Neurologic Examination; D011379:Prognosis; D012307:Risk Factors
D020780:Matrix Metalloproteinase 9