[The neuroprotector effect of a new taurine derivative on a model of compression spinal cord trauma in rats].
The neuroprotector effect of a new taurine derivative, 2-(1-phenylethyl)-aminoethanesulfonyl-2-propylamide hydrochloride, has been studied in rats with model compression spinal cord trauma. The drug favored restoration of the motor function of posterior extremities in rats with the model spinal cord trauma and significantly decreased the lethality in test animals. The taurine derivative normalized the energy metabolism, lipid peroxidation and antioxidant system in animals with spinal cord trauma. The neuroprotector effect of the new taurine derivative significantly exceeds the action of cerebrolysine.
Sapronov
N S
NS
Bul'on
V V
VV
Kuznetsova
N N
NN
Selina
E N
EN
D000596:Amino Acids / Q000008:administration & dosage; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D051381:Rats; D020127:Recovery of Function / Q000187:drug effects*; D013117:Spinal Cord Compression / Q000188:drug therapy* / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D013654:Taurine / Q000008:administration & dosage* / Q000031:analogs & derivatives
D000596:Amino Acids; D018696:Neuroprotective Agents; D013654:Taurine; C006952:cerebrolysin