title: Cerebrospinal fluid mononuclear cell predominance is not related to symptom duration in children with enteroviral meningitis.
abstract: We used a binomial regression model to determine the relationship between the percent of cerebrospinal fluid (CSF) mononuclear white blood cells and symptom duration in children with proven enteroviral meningitis. The odds of a CSF white blood cell being mononuclear increased by 15.7% (95% confidence interval: -3.8% to 38.0%; P = .11) for each day of symptoms. Fifty percent of patients with symptoms of 1 day or less had predominance of mononuclear cells among CSF white blood cells. These findings suggest that factors other than symptom duration influence the composition and evolution of the CSF white blood cell response to enteroviral infection.
authors.affiliation: Division of Infectious Diseases, Clinical Virology Laboratory, and the Department of Infection Prevention and Control, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. shahs@email.chop.edu
authors.forename: Samir S
authors.initials: SS
authors.lastname: Shah
authors.forename: Richard L
authors.initials: RL
authors.lastname: Hodinka
authors.forename: Jacob L
authors.initials: JL
authors.lastname: Turnquist
authors.forename: Michael R
authors.initials: MR
authors.lastname: Elliott
authors.forename: Susan E
authors.initials: SE
authors.lastname: Coffin
mesh_terms: D000293:Adolescent; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000821:virology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004770:Enterovirus / Q000235:genetics / Q000254:growth & development; D004769:Enterovirus Infections / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000821:virology; D016133:Polymerase Chain Reaction; D013997:Time Factors