NMR study on cis-N-[4-[4-(1,2-benzisozole-3-yl)-1-piperazinyl] butyl]cyclohexane-1,2-dicarboximide monohydrochloride dihydrate.
Cis-N-[4-[4-(1,2-benzisozole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dihydrate was studied spectroscopically. Complete NMR assignments were made using DEPT, H-H COSY, as well as HMQC and HMBC heteronuclear correlation techniques. The hydrochloride salt was found at delta > 10. The dihydrate was present in the region delta 3-4 in DMSO-d6 solvent. Asymmetry carbon C3 brought chemical-shift-nonequivalent of cis-cyclohexanyl group, splitting four systems H1, H1', H2 and H2'. Diamagnetic anisotropy of benzisozolyl group results in three troops peaks of piperazinyl group.
Feng
Yongbin
Y
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
Lin
Jimao
J
Lin
Zhenguang
Z
Li
Hongmei
H
D002247:Carbon Isotopes; D003510:Cyclohexanes / Q000737:chemistry*; D007094:Imides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000737:chemistry*; D011522:Protons
D002247:Carbon Isotopes; D003510:Cyclohexanes; D007094:Imides; D010879:Piperazines; D011522:Protons; C509105:cis-N-(4-(4-(1,2-benzisozole-3-yl)-1-piperazinyl) butyl)cyclohexane-1,2-dicarboximide monohydrochloride dihydrate