[Antiviral effectiveness of the combined use of amixine and virasole in experimental hemorrhagic fever with renal syndrome in sucking albino mice].
The antiviral effectiveness of the combined and single use of superlow-dose amixine and virasole on the course of experimental hemorrhagic fever with renal syndrome was studied in sucking albino mice parenterally infected with their virus Hantaan. The co-administration of virasole and amixine was shown to protect 52% of the infected animals from death, which is superior to the effect of their monotherapy. The combined use of the drugs substantially prolongs the survival of albino mice after their infection and the level of brain viral reproduction suppression ( delta = 3.21 g) in the experimental group as compared to the controls and to the mice given only one of the drugs.
Loginova
S Ia
SIa
Koval'chuk
A V
AV
Borisevich
S V
SV
Kopylova
N K
NK
Pashchenko
Iu I
IuI
Khamitov
R A
RA
Maksimov
V A
VA
Shuster
A M
AM
D000818:Animals; D000833:Animals, Suckling; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000821:virology; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D018063:Hantaan virus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000188:drug therapy* / Q000821:virology; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D013994:Tilorone / Q000008:administration & dosage / Q000627:therapeutic use*
D000998:Antiviral Agents; D012254:Ribavirin; D013994:Tilorone