Pt(II)- or Au(III)-catalyzed [3+2] cycloaddition of metal-containing azomethine ylides: highly efficient synthesis of the mitosene skeleton.
[reaction: see text] Only 1-3 mol % of PtCl(2) or AuBr(3) was sufficient to promote generation and [3+2] cycloaddition of transition-metal-containing azomethine ylides derived from N-(o-alkynylphenyl)imines bearing an internal alkyne moiety. A highly efficient method for the preparation of synthetically useful tricyclic indole derivatives having a substituent at the 3-position of the indole nucleus was established by this method.
Kusama
Hiroyuki
H
Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Japan.
Miyashita
Yuichi
Y
Takaya
Jun
J
Iwasawa
Nobuharu
N