title: [Metalloproteinases activity (MMP-2, MMP-9) in distal stumps of rat sciatic nerves].
abstract: In case of nerve transection we observed biochemical and morphological changes in axons. The aim of present study was to examine neurotrophic activity of two important metalloproteinases: MMP-2 and MMP-9. To examine their activity in nerve supernatants, gelatin zymography was used. We concluded that the levels of MMP-2 and MMP-9 expression are increased in 4th, 5th and 6th day after nerve transection. The identification of the molecular mechanism underlying this activity could be the main key for the elaborating of further strategies for repair of the damaged nervous system.
authors.affiliation: Katedry i Zakładu Fizjologii Slaskiej Akademii Medycznej w Katowicach.
authors.forename: Izabella
authors.initials: I
authors.lastname: Woszczycka-Korczyńska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Górka
authors.forename: Iwona
authors.initials: I
authors.lastname: Matuszek
authors.forename: Marita
authors.initials: M
authors.lastname: Pietrucha-Dutczak
authors.forename: Joanna
authors.initials: J
authors.lastname: Lewin-Kowalik
mesh_terms: D000672:Amputation Stumps; D000818:Animals; D004195:Disease Models, Animal; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009410:Nerve Degeneration / Q000201:enzymology; D009416:Nerve Regeneration / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000201:enzymology* / Q000473:pathology
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9