title: Effect of temperature on the maximum rate of rise of tension in denervated rat diaphragm muscle.
abstract: Effects of chronic denervation and temperature were studied on the maximum rate of rise of tension in isometric twitch and tetanus of rat diaphragm muscles. The muscles were denervated for 15-20 days and the maximum rate of rise of tension was measured according to Hill (1951). The results showed that the maximum rate of rise of tension in twitch and tetanus was temperature dependent, exponentially increasing with increasing temperatures in both the normal and denervated muscles. A further observation was that the maximum rate of rise of tension in denervated muscle was always smaller than normal controls. It is suggested that probable changes in the series elasticity and duration of active state in the denervated muscle are responsible for the observed changes.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
authors.forename: K N
authors.initials: KN
authors.lastname: Shaikh
authors.forename: M A
authors.initials: MA
authors.lastname: Azeem
authors.forename: H A
authors.initials: HA
authors.lastname: Shaikh