Recombinant Salmonella vaccines for biodefence.
There is a requirement for vaccines to protect against pathogens that may be misused for bioterrorism or biowarfare purposes. In particular, biodefence vaccines are required that may be used for safe and easy immunisation of populations and that can rapidly induce mucosal immunity to provide protection at the lung surface against a range of airborne agents. To address this need, recombinant Salmonella vaccines are being developed. In this review, the technologies used, considerations needed, progress made, and future prospects for developing multivalent Salmonella-based vaccines for biodefence are discussed.
Atkins
Helen S
HS
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK. hsatkins@dstl.gov.uk
Morton
Margaret
M
Griffin
Kate F
KF
Stokes
Margaret G M
MG
Nataro
James P
JP
Titball
Richard W
RW
D001694:Biological Warfare; D023482:Bioterrorism; D006801:Humans; D012475:Salmonella / Q000235:genetics* / Q000276:immunology; D022562:Salmonella Vaccines / Q000235:genetics* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
D022562:Salmonella Vaccines; D014614:Vaccines, Synthetic