[A clinical study on CD178 positive T lymphocyte in hemorrhagic fever with renal syndrome].
BACKGROUND
To further probe into the role of CD178 in the pathogenesis of hemorrhagic fever with renal syndrome (HFRS).


METHODS
The expression of CD178 and HLA-DR on T cell subsets in peripheral blood of patients with HFRS and their dynamic changes were detected by Flow cytometry.


RESULTS
CD4+ CD178+ and CD8+ CD178+ T lymphocytes both in fever and polyuria phases were significantly higher than those in normal controls, while there was no significant difference between the both phases of HFRS (P > 0.05). CD178 expression on CD4+ HLA-DR+ and CD8+ HLA-DR+ T lymphocytes were significantly higher than those in normal controls (P < 0.05, P < 0.01, P < 0.001, P < 0.001), while there was no significant difference between CD4+ HLA-DR+ and CD8+ HLA-DR+ T lymphocytes (P > 0.05).


CONCLUSIONS
CD178 was expressed on both CD4+ and CD8+ T cell subsets, but mainly on CD8+ T cell subsets both in early stage and in later stage in the pathogenesis of HFRS. Cytotoxic T lymphocyte (CTL) might kill target cells infected by hantavirus (HV) and eliminate HV via cell apoptosis mediated by CD178 in early stage of HFRS. In later stage of HFRS, CD178 might reduce antigen-specific T lymphocytes by activation induced cell death (AICD) and help to maintain the homeostasis of immune system.
Gai
Zhong-tao
ZT
Ji'nan Hospital for Infectious Diseases, Ji'nan 250021, China.
Zhang
Ying
Y
Dong
Ge-feng
GF
Zu
Yan-hui
YH
Zhang
Yong
Y
Wu
Si-ying
SY
D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D053222:Fas Ligand Protein / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000276:immunology*; D006482:Hemorrhagic Fevers, Viral / Q000097:blood / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D055815:Young Adult
D053222:Fas Ligand Protein