title: Polyunsaturated fatty acid supplementation in MS.
abstract: This article focuses on polyunsaturated fatty acid (PUFA) supplementation, which is a popular form of complementary and alternative therapy among people with MS. Owing to their popularity, clinicians should be knowledgeable about the PUFA supplements that are widely available, and the efficacy and safety data from clinical studies. Small-scale studies have demonstrated trends towards some beneficial effects. PUFA supplementation is generally well tolerated, although some specific supplements are best avoided and some clinical situations warrant caution. A review of the efficacy and safety data suggests that PUFA supplementation may be a promising approach. Large-scale trials are required to confirm the benefits.
authors.affiliation: Complementary and Alternative Medicine Program, Rocky Mountain Multiple Sclerosis Center, Englewood, Colorado 80113, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Stewart
authors.forename: A C
authors.initials: AC
authors.lastname: Bowling
mesh_terms: D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D043371:Fatty Acids, Omega-6 / Q000627:therapeutic use*; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6