[Low-dose weekly paclitaxel therapy proved useful for a case of recurrent gastric cancer with clinically latent hepatic cirrhosis].
The patient was a 68-year-old-man who suffered from recurrent peritoneal gastric cancer. He was initially treated with TS-1 as an outpatient. However, his serum CEA level elevated in March 2004, and he complained of epigastric pain in June. A chest and abdominal CT revealed lung and local recurrence. He began weekly paclitaxel as second-line chemotherapy in September. Paclitaxel was infused once a week for two weeks as one cycle, at a dose of 60 mg because of the clinically latent hepatic cirrhosis. One month after the first infusion therapy, epigastric pain was greatly reduced. A CT scan showed the lung metastasis had disappeared and the size of the tumor around the anastomosis was reduced to 50% after 2 months. The toxic events were appetite loss (grade 2) and alopecia (grade 2).
Yamada
Roppei
R
Dept. of Gastroenterological Center, Yokohama City University Medical Center.
Ohshima
Takashi
T
Sato
Tsutomu
T
Ohtsuka
Yuichi
Y
Kunisaki
Chikara
C
Imada
Toshio
T
D000368:Aged; D000713:Anastomosis, Roux-en-Y; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005743:Gastrectomy; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D009361:Neoplasm Invasiveness; D017239:Paclitaxel / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel