The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres: their evaluation in an animal osteomyelitis model.
Ciprofloxacin hydrochloride-loaded microspheres were prepared by a spray-drying method using pectin and chitosan. The effects of different polymers and drug ratios were investigated. The most appropriate carriers were selected by in vitro testing. A rat methicillin-resistant Staphylococcus aureus osteomyelitis model was used to evaluate the effects of the loaded microspheres. The drug was released rapidly from the pectin carrier but this was more sustained in the chitosan formulation.Chitosan microspheres loaded with ciprofloxacin hydrochloride were more effective for the treatment of osteomyelitis than equivalent intramuscular antibiotics.
Orhan
Z
Z
Department of Orthopaedics, Abant Izzet Baysal University, Düzce, Turkey. zorhan@excite.com
Cevher
E
E
Mülazimoglu
L
L
Gürcan
D
D
Alper
M
M
Araman
A
A
Ozsoy
Y
Y
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D048271:Chitosan / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D004195:Disease Models, Animal; D004339:Drug Compounding / Q000379:methods; D004353:Drug Evaluation, Preclinical; D008297:Male; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008863:Microspheres; D010019:Osteomyelitis / Q000188:drug therapy*; D010368:Pectins / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy*; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D002939:Ciprofloxacin; D010368:Pectins; D048271:Chitosan