title: Investigation of a scanned cylindrical ultrasound system for breast hyperthermia.
abstract: This paper investigates the feasibility of a scanned cylindrical ultrasound system for producing uniform heating from the central to the superficial portions of the breast or localized heating within the breast at a specific location. The proposed system consists of plane ultrasound transducer(s) mounted on a scanned cylindrical support. The breast was immersed in water and surrounded by this system during the treatment. The control parameters considered are the size of the transducer, the ultrasound frequency, the scan angle and the shifting distance between the axes of the breast and the system. Three-dimensional acoustical and thermal models were used to calculate the temperature distribution. Non-perfused phantom experiments were performed to verify the simulation results. Simulation results indicate that high frequency ultrasound could be used for the superficial heating, and the scan angle of the transducer could be varied to obtain an appropriate high temperature region to cover the desired treatment region. Low frequency ultrasound could be used for deep heating and the high temperature region could be moved by shifting the system. In addition, a combination of low and high frequency ultrasound could result in a portion treatment from the central to the superficial breast or an entire breast treatment. Good agreement was obtained between non-perfused experiments and simulation results. The findings of this study can be used to determine the effects of the control parameters of this system, as well as to select the optimal parameters for a specific treatment.
authors.affiliation: Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
authors.forename: Kuen-Cheng
authors.initials: KC
authors.lastname: Ju
authors.forename: Li-Te
authors.initials: LT
authors.lastname: Tseng
authors.forename: Yung-Yaw
authors.initials: YY
authors.lastname: Chen
authors.forename: Win-Li
authors.initials: WL
authors.lastname: Lin
mesh_terms: D000162:Acoustics; D001831:Body Temperature; D001940:Breast / Q000473:pathology*; D003198:Computer Simulation; D005334:Fever; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced; D021621:Imaging, Three-Dimensional; D015233:Models, Statistical; D010477:Perfusion; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D013696:Temperature; D013997:Time Factors; D014464:Ultrasonic Therapy; D014465:Ultrasonics