Synthesis of enantiopure allylamines by reductive alkylation of amino epoxides with organolithium reagents.
[reaction: see text] Transformation of enantiopure (2R,1'S)-2-(1-aminoalkyl)epoxides 1 into the corresponding allylamines 2 is described. The opening of the epoxide ring with different organolithium compounds takes place with total selectivity and in high yields.
Concellón
José M
JM
Departamento de Química Orgánica e Inorgánica, Facultad de Química Universidad de Oviedo, Julián Clavería, Spain. jmcg@uniovi.es
Suárez
José Ramón
JR
Del Solar
Virginia
V