Effects of noise-induced hearing loss at young age on voice onset time and gap-in-noise representations in adult cat primary auditory cortex.
Here we show that mild hearing loss induced by noise exposure in early age causes a decrease in neural temporal resolution when measured in adulthood. We investigated the effect of this chronic hearing loss on the representation of a voice onset time (VOT) and a gap-duration continuum in primary auditory cortex (AI) in cats, which were exposed at the age of 6 weeks to a 120-dB SPL, 5-kHz 1/3 octave noise band for 2 h. The resulting hearing loss measured using auditory brainstem responses and cortical multiunit thresholds at 4-6 months of age was 20-40 dB between 1 and 32 kHz. Multiple single-unit activity was recorded in seven noise-exposed cats and nine control cats related to the presentation of a/ba/-/pa/ continuum in which VOT was varied in 5-ms step from 0 to 70 ms. We also obtained data for noise bursts with gaps, of duration equal to the VOT, embedded in noise 5 ms after the onset. Both stimuli were presented at 65 dB SPL. Minimum VOT and early-gap duration were defined as the lowest value in which an on-response, significantly above the spontaneous activity, to both the leading and trailing noise bursts or vowel was obtained. The mild chronic noise-induced hearing loss increased the minimum detectable VOT and gap duration by 10 ms. We also analyzed the maximum firing rate (FRmax) and the latency of the responses as a function of VOT and gap duration and found a significant reduction in the FRmax to the trailing noise burst for gap durations above 50 ms. This suggests that mild hearing loss acquired in early age may affect cortical temporal processing in adulthood.
Aizawa
Naotaka
N
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada.
Eggermont
Jos J
JJ
D000161:Acoustic Stimulation; D000375:Aging; D000818:Animals; D001303:Auditory Cortex / Q000254:growth & development / Q000503:physiopathology*; D001309:Auditory Threshold / Q000502:physiology; D002415:Cats; D004195:Disease Models, Animal; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D014828:Vocalization, Animal