Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival.
OBJECTIVE
To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.


METHODS
We examined the genotypes of 125 colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR-restriction fragment length polymorphism (RFLP).


RESULTS
SULT1A1 *2/*2 genotype (OR=2.49, 95%CI=1.48-4.19, P=0.0002) and *2 allele (OR=1.56, 95%CI=1.16-2.10, P=0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender, age, Dukes' stage, growth pattern, and differentiation (P=0.03).


CONCLUSIONS
Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients.
Sun
Xiao-Feng
XF
Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoping, S-581 85 Linkoping, Sweden. xiasu@ibk.liu.se
Ahmadi
Ahmad
A
Arbman
Gunnar
G
Wallin
Asa
A
Asklid
Daniel
D
Zhang
Hong
H
D015239:Arylsulfotransferase / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D015996:Survival Rate; D013548:Sweden
D002352:Carrier Proteins; D007527:Isoenzymes; C484555:GSTA1 protein, human; D005982:Glutathione Transferase; D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human