[Metalloproteinases activity (MMP-2, MMP-9) in distal stumps of rat sciatic nerves].
In case of nerve transection we observed biochemical and morphological changes in axons. The aim of present study was to examine neurotrophic activity of two important metalloproteinases: MMP-2 and MMP-9. To examine their activity in nerve supernatants, gelatin zymography was used. We concluded that the levels of MMP-2 and MMP-9 expression are increased in 4th, 5th and 6th day after nerve transection. The identification of the molecular mechanism underlying this activity could be the main key for the elaborating of further strategies for repair of the damaged nervous system.
Woszczycka-Korczyńska
Izabella
I
Katedry i Zakładu Fizjologii Slaskiej Akademii Medycznej w Katowicach.
Górka
Dariusz
D
Matuszek
Iwona
I
Pietrucha-Dutczak
Marita
M
Lewin-Kowalik
Joanna
J
D000672:Amputation Stumps; D000818:Animals; D004195:Disease Models, Animal; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009410:Nerve Degeneration / Q000201:enzymology; D009416:Nerve Regeneration / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000201:enzymology* / Q000473:pathology
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9