A novel strategy for protection against organophosphate toxicity: Evolution of cyclic inhibitors with high affinity for the acetylcholinesterase peripheral site.
Cusack
Bernadette
B
Mayo Clinic College of Medicine, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Romanovskis
Peteris
P
Johnson
Joseph L
JL
Etienne
Gathline
G
Rosenberry
Terrone L
TL
D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000633:toxicity*; D015195:Drug Design; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000633:toxicity*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D010456:Peptides, Cyclic; D000110:Acetylcholinesterase