title: Expression of TFAP2beta and TFAP2gamma genes in Xenopus laevis.
abstract: The embryonic expression patterns of two additional members of the transcription factor TFAP2 family in Xenopus laevis, TFAP2beta and TFAP2gamma, are described. Both genes share overlapping expression domains with the previously characterized TFAP2alpha in this species, although differences exist. All three genes are expressed in the neural crest (NC) region at late gastrula to early neurula stages. TFAP2alpha and TFAP2gamma are also expressed in outer, epidermal cells, while TFAP2beta is essentially NC-specific. All three are induced by Wnt/beta-catenin -- BMP signals and all bind to a consensus TFAP2 recognition site from an epidermal keratin gene.
authors.affiliation: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 6B, Room 412, Bethesda, MD 20892, USA.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Luo
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Sargent
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D008969:Molecular Sequence Data; D010802:Phylogeny; D015398:Signal Transduction; D050656:Transcription Factor AP-2 / Q000235:genetics*; D051153:Wnt Proteins / Q000378:metabolism; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics*
chemical_list: D019485:Bone Morphogenetic Proteins; D050656:Transcription Factor AP-2; D051153:Wnt Proteins