Determination of ceftriaxone sodium in pharmaceutical formulations by flow injection analysis with acid potassium permanganate chemiluminescence detection.
Based on the chemiluminescence (CL) emission generated from the oxidation of ceftriaxone sodium alkali hydrolysate by potassium permanganate in polyphosphoric acid (PPA), a novel determination method for ceftriaxone sodium was developed by using a flow-injection technique. The calibration curve appears to be linear in the range between 0.05 and 100 microg mL(-1) with a detection limit (3sigma) of 25 ng mL(-1), and a relative standard deviation (RSD) of 0.6% for eleven replicate determinations of 5.0 microg mL(-1) ceftriaxone sodium. The proposed method has been successfully utilized for the determination of ceftriaxone sodium in pharmaceutical formulations, while the chemiluminescence reaction mechanisms were investigated.
Zhang
Deyi
D
Institute of Chemistry, Northwest Normal University, Lanzhou 730070, PR China.
Ma
Yongjun
Y
Zhou
Min
M
Li
Li
L
Chen
Hui
H
D002138:Calibration; D002443:Ceftriaxone / Q000032:analysis*; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011196:Potassium Permanganate / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013997:Time Factors
D004364:Pharmaceutical Preparations; D010756:Phosphoric Acids; D011108:Polymers; D011196:Potassium Permanganate; D002443:Ceftriaxone; C047269:polyphosphoric acid