title: Does the proteome encode organellar pH?
abstract: Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the pI of proteins and the pH of organelles co-evolve to optimize function?
authors.affiliation: Department of Physiology, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Brett
authors.forename: Mark
authors.initials: M
authors.lastname: Donowitz
authors.forename: Rajini
authors.initials: R
authors.lastname: Rao
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015388:Organelles / Q000502:physiology*; D020543:Proteome / Q000502:physiology*
chemical_list: D020543:Proteome