Salmonella enterica serovar Typhimurium ompS1 and ompS2 mutants are attenuated for virulence in mice.
Salmonella enterica serovar Typhimurium mutants with mutations in the ompS1 and ompS2 genes, which code for quiescent porins, were nevertheless highly attenuated for virulence in a mouse model, indicating a role in pathogenesis. Similarly, a strain with a mutation in the gene coding for LeuO, a positive regulator of ompS2, was also attenuated.
Rodríguez-Morales
Olivia
O
Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, México.
Fernández-Mora
Marcos
M
Hernández-Lucas
Ismael
I
Vázquez
Alejandra
A
Puente
José Luis
JL
Calva
Edmundo
E
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D012481:Salmonella Infections, Animal / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014774:Virulence
D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; C430340:LeuO protein, E coli; D014157:Transcription Factors