title: Mapping of panda plumage color locus on the microsatellite linkage map of the Japanese quail.
abstract: BACKGROUND
  Panda (s) is an autosomal recessive mutation, which displays overall white plumage color with spots of wild-type plumage in the Japanese quail (Coturnix japonica). In a previous study, the s locus was included in the same linkage group as serum albumin (Alb) and vitamin-D binding protein (GC) which are mapped on chicken (Gallus gallus) chromosome 4 (GGA4). In this study, we mapped the s locus on the microsatellite linkage map of the Japanese quail by linkage analysis.
  
  
  RESULTS
  Segregation data on the s locus were obtained from three-generation families (n = 106). Two microsatellite markers derived from the Japanese quail chromosome 4 (CJA04) and three microsatellite markers derived from GGA4 were genotyped in the three-generation families. We mapped the s locus between GUJ0026 and ABR0544 on CJA04. By comparative mapping with chicken, this locus was mapped between 10.0 Mb and 14.5 Mb region on GGA4. In this region, the endothelin receptor B subtype 2 gene (EDNRB2), an avian-specific paralog of the mammalian endothelin receptor B gene (EDNRB), is located. Because EDNRB is responsible for aganglionic megacolon and spot coat color in mouse, rat and equine, EDNRB2 is suggested to be a candidate gene for the s locus.
  
  
  CONCLUSIONS
  The s locus and the five microsatellite markers were mapped on CJA04 of the Japanese quail. EDNRB2 was suggested to be a candidate gene for the s locus.
authors.affiliation: Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan. j4111028@guedu.cc.gifu-u.ac.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Miwa
authors.forename: Miho
authors.initials: M
authors.lastname: Inoue-Murayama
authors.forename: Naoki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Boniface Baboreka
authors.initials: BB
authors.lastname: Kayang
authors.forename: Makoto
authors.initials: M
authors.lastname: Mizutani
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shin'ichi
authors.initials: S
authors.lastname: Ito
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics; D002874:Chromosome Mapping; D003370:Coturnix / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005241:Feathers; D005808:Genes, Recessive; D008040:Genetic Linkage; D018895:Microsatellite Repeats; D010858:Pigmentation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D044023:Receptor, Endothelin B / Q000235:genetics
chemical_list: D044023:Receptor, Endothelin B; D004247:DNA