title: Impact of an infection control program in an intensive care unit in France.
abstract: OBJECTIVE
  To evaluate the impact of an infection control program in an intensive care unit (ICU).
  
  
  METHODS
  Prospective before-after study. Two 6-month study periods were compared; between these periods, an infection control program based on isolation was implemented.
  
  
  METHODS
  Polyvalent ICU of Montpellier Teaching Hospital.Patients. Any patient who was hospitalized in the ICU for >48 hours and was discharged during 1 of the 2 periods.
  
  
  METHODS
  The main patient-related variables were sex, age at admission, type of patient (surgical, medical, or trauma), Simplified Acute Physiology Score II, length of ICU stay, need for intubation, duration of exposure to invasive devices, onset of nosocomial infection and pathogens responsible, and death. We compared the 2 study periods with respect to the incidence of 4 nosocomial infections (pneumonia, urinary tract infection, bacteremia, and catheter-associated infection), the frequency of infection with the main multidrug-resistant pathogens, and patient survival.
  
  
  RESULTS
  Patients in periods 1 and 2 were similar with regard to sex, age, physiology score, and exposure to invasive devices. The rates of infection with multidrug-resistant pathogens were significantly lower during period 2 than during period 1 (infection rate: 28.1% of patients in period 1 and 9.6% of patients in period 2 [P = .01]; pneumonia rate: 32.6% of patients in period 1 and 4.2% of patients in period 2 [P = .008]). The mortality rate among patients with nosocomial pneumonia was 38.2% in period 1 and 4.3% in period 2 (P = .009).
  
  
  CONCLUSIONS
  After implementation of an infection control program, the rate of infection with multidrug-resistant pathogens decreased, as did the mortality rate among patients with nosocomial pneumonia.
authors.affiliation: Department of Medical Information, University Hospital of Montpellier, France. verdier_regis@yahoo.fr
authors.forename: Regis
authors.initials: R
authors.lastname: Verdier
authors.forename: Sylvie
authors.initials: S
authors.lastname: Parer
authors.forename: Helene
authors.initials: H
authors.lastname: Jean-Pierre
authors.forename: Pierre
authors.initials: P
authors.lastname: Dujols
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Picot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D018432:Drug Resistance, Multiple; D005260:Female; D005602:France / Q000453:epidemiology; D006784:Hospitals, Teaching; D006801:Humans; D017053:Infection Control; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010356:Patient Isolation; D011014:Pneumonia / Q000453:epidemiology / Q000382:microbiology; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology; D012122:Ventilators, Mechanical / Q000009:adverse effects