Determination of astemizole by a spectrophotometric charge- transfer method.
Iodine-astemizole charge-transfer complex has been utilized for the assay of astemizole. The complex formed in the proposed method shows strong absorption at 360 nm with a corresponding molar absorptivity. epsilon of 3.26 x 10 L mol1 cm-1 and obeyance of Beer's law over the concentration range 2-12 pg/mi. When the proposed method was applied to commercial tablets labeled to contain 10 mg of active ingredient per tablet, the mean percentage found was 99.72 +/- 1.36. Analysis of variance, (ANO VA), and added recovery experiments indicated adequate precision and accuracy for the method.
Al-Deeb
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Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh-11451, Saudi Arabia.
Al-Khamees
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Hagga
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Al-Awady
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