Anesthetic management in two siblings with glutaric aciduria type 1.
Glutaric aciduria type 1 (GA-1) is an inborn error of metabolism that results from a deficiency of glutaryl-CoA dehydrogenase. This disorder mainly manifests in early childhood and most patients with this condition develop a dystonic-dyskinetic syndrome. We report the anesthetic management of two sisters with GA-1, aged 30 and 17 months respectively at the time of surgery, who presented with macrocephaly and psychomotor delay. The children required CSF shunting procedures for hydrocephalus and subdural fluid collections, which were performed under total intravenous anesthesia with propofol and remifentanil.
Hernández-Palazón
Joaquín
J
Staff Anaesthesiologist, Department of Anaesthesia, H.U. Virgen de la Arrixaca, Murcia, Spain. joapal@ono.com
Sánchez-Ródenas
Lorenzo
L
Martínez-Lage
Juan F
JF
Collado
Isabel Castaño
IC
D000758:Anesthesia / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D002557:Cerebrospinal Fluid Shunts / Q000379:methods; D002675:Child, Preschool; D020821:Dystonic Disorders; D005260:Female; D005977:Glutarates / Q000378:metabolism*; D050770:Glutaryl-CoA Dehydrogenase / Q000172:deficiency*; D006257:Head / Q000002:abnormalities; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000601:surgery; D007223:Infant; D008661:Metabolism, Inborn Errors / Q000150:complications / Q000235:genetics / Q000601:surgery*; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D011596:Psychomotor Disorders / Q000150:complications; D000077208:Remifentanil; D035781:Siblings
D018686:Anesthetics, Intravenous; D005977:Glutarates; D010880:Piperidines; D050770:Glutaryl-CoA Dehydrogenase; C035736:glutaric acid; D000077208:Remifentanil; D015742:Propofol