title: An efficient approach to the asymmetric total synthesis of (-)-anisodine.
abstract: -Anisodine (l-6,7-epoxy-3-tropyl-alpha-hydroxytropate), which was isolated from the medicinal plant Scopolia tanguticus Maxim, was the first efficiently prepared using 6-beta-acetyltropine as the starting material via a key step of the Sharpless asymmetric dihydroxylation (AD). The intermediate compounds 10 and 11 showed promising cholinergic activity.
authors.affiliation: School of Pharmaceuticals, Xinxiang Medical College, China. jbchang@public2.zz.ha.cn
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
authors.forename: Weilin
authors.initials: W
authors.lastname: Xie
authors.forename: Limin
authors.initials: L
authors.lastname: Wang
authors.forename: Nianchun
authors.initials: N
authors.lastname: Ma
authors.forename: Senxiang
authors.initials: S
authors.lastname: Cheng
authors.forename: Jingxi
authors.initials: J
authors.lastname: Xie
mesh_terms: D000818:Animals; D018680:Cholinergic Antagonists / Q000138:chemical synthesis / Q000737:chemistry; D006168:Guinea Pigs; D006900:Hydroxylation; D007082:Ileum / Q000187:drug effects; D015394:Molecular Structure; D012602:Scopolamine Derivatives / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D014326:Tropanes / Q000737:chemistry
chemical_list: D018680:Cholinergic Antagonists; D012602:Scopolamine Derivatives; D014326:Tropanes; C012183:anisodine