A possible role of GLP-1 in the pathophysiology of early dumping syndrome.
Exaggerated plasma concentrations of GLP-1 precede reactive hypoglycemia after oral glucose in gastrectomy patients, resulting in late dumping syndrome. Recently, we showed that GLP-1 elicits the activation of sympathetic outflow. Because sympathetic activation is thought to be a cause of early dumping, we hypothesized that exaggerated GLP-1 may contribute to the pathophysiology of early dumping syndrome. In 11 patients after gastrectomy and 14 controls, blood pressure, heart rate, and plasma concentrations of norepinephrine, epinephrine, GLP-1, glucagon, insulin, and glucose were measured after oral glucose. In gastrectomy patients, GLP-1, norepinephrine, and heart rate peaked 15 to 30 min after oral glucose. Significant positive correlations were found among GLP-1, norepinephrine, and heart rate at 30 min, and these parameters at 30 min were significantly higher in patients with early dumping syndrome. These results suggest that GLP-1 is involved in the pathophysiology of early dumping syndrome.
Yamamoto
Hiroshi
H
Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan. yhiroshi@belle.shiga-med.ac.jp
Mori
Tsuyoshi
T
Tsuchihashi
Hiroshi
H
Akabori
Hiroya
H
Naito
Hiroyuki
H
Tani
Tohru
T
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D002395:Catecholamines / Q000097:blood; D004377:Dumping Syndrome / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000379:methods; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery
D015415:Biomarkers; D001786:Blood Glucose; D002395:Catecholamines; D007328:Insulin; D052216:Glucagon-Like Peptide 1