Acquired amegakaryocytic thrombocytopenic purpura.
Acquired amegakaryocytic thrombocytopenia is an unusual hematologic disorder characterized by thrombocytopenia in association with markedly diminished bone marrow megakaryocytes. We report a case that responded to treatment with cyclosporine but not to IL-11. The bone marrow biopsy, repeated after resolution of thrombocytopenia, showed normal number of megakaryocytes.
Agarwal
Neeraj
N
Division of Hematology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
Spahr
Joseph E
JE
Werner
Theresa L
TL
Newton
David L
DL
Rodgers
George M
GM
D001854:Bone Marrow Cells; D002452:Cell Count; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017370:Interleukin-11 / Q000494:pharmacology / Q000627:therapeutic use*; D008533:Megakaryocytes / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*
D017370:Interleukin-11; D016572:Cyclosporine