Transcriptional repression of interleukin-2 in human systemic lupus erythematosus.
T cells from patients with SLE produce decreased amounts of interleukin-2 (IL-2), a central cytokine in the regulation of the immune response. We discuss herein the abnormalities underlying IL-2 deficiency in SLE T cells.
Katsiari
Christina G
CG
Dept. of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20190, USA. christina.katsiari@na.amedd.army.mil
Tsokos
George C
GC
D001665:Binding Sites / Q000235:genetics; D051786:Cyclic AMP Response Element Modulator / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics* / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D011401:Promoter Regions, Genetic / Q000235:genetics; D018808:Transcription Factor AP-1 / Q000378:metabolism; D051996:Transcription Factor RelA / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics
C497410:CREM protein, human; D007376:Interleukin-2; D018808:Transcription Factor AP-1; D051996:Transcription Factor RelA; D051786:Cyclic AMP Response Element Modulator