title: [Role of cGMP-dependent protein kinase in the cardiovascular system].
abstract: cGMP-dependent protein kinase (PKG) is the major intracellular receptor for cyclic guanosine monophosphate (cGMP). Two forms of PKG, PKG-I and PKG-II, occur in mammalian tissues. PKG may mediate nitric oxide-cGMP-induced vasodilation through decreasing intracellular calcium concentration by the activation of calcium-activated potassium channel on the cell membrane and phosphorylation of phospholamban (PLB) and IP3 receptor-associated PKG-I substrate (IRAG) on the sarcoplasmic reticulum. PKG may also decrease the sensitivity of myosin to calcium by stimulating the activity of myosin light chain phosphatase and by inhibiting Rho kinase activity. PKG plays an important role in regulating the gene expression, phenotype, and proliferation of vascular smooth muscle cells. PKG activation inhibits platelet aggregation and myocardial hypertrophy. Recent studies indicate that the alternations of PKG expression and activity are closely related with the pathogenesis of atherosclerosis, restenosis, hypertension, hyperlipemia as well as nitrate tolerance.
authors.affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Tong
authors.forename: Dou
authors.initials: D
authors.lastname: Dou
authors.forename: J Raj
authors.initials: JR
authors.lastname: Usha
authors.forename: Yuan-Sheng
authors.initials: YS
authors.lastname: Gao
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002320:Cardiovascular Physiological Phenomena; D049109:Cell Proliferation; D017869:Cyclic GMP-Dependent Protein Kinases / Q000502:physiology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism*
chemical_list: D024681:Potassium Channels, Calcium-Activated; D017869:Cyclic GMP-Dependent Protein Kinases; D002118:Calcium