[Antiviral agents in influenza--current recommendations. Anti-influenza agents are not a substitution for but a complement to vaccination].
This article summarizes a Swedish consensus guidance document on the use of antiviral drugs in the management of influenza. Vaccination remains the cornerstone for influenza prophylaxis. Treatment with neuraminidase inhibitors is recommended for high-risk groups and individuals hospitalised with influenza. Chemoprophylaxis is targeted at high-risk groups and should be considered on a case by case basis depending on the circumstances. Unvaccinated at-risk patients or seasonal vaccine strain mismatch were identified as potential indications for antiviral prophylaxis. Oseltamivir prophylaxis can otherwise be considered for influenza in a household including an at-risk individual and in outbreaks in hospitals and nursing homes. The use of antivirals in a pandemic situation is also discussed.
Uhnoo
Ingrid
I
Infektionskliniken, Akademiska sjukhuset, avdelningen for klinik och preklinik 1, Läkemedelsverket, Uppsala. ingrid.uhnoo@mpa.se
Linde
Annika
A
D000081:Acetamides / Q000008:administration & dosage; D000547:Amantadine / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage*; D032921:Consensus; D004196:Disease Outbreaks / Q000517:prevention & control; D024882:Drug Resistance, Viral; D006146:Guanidines / Q000008:administration & dosage; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000188:drug therapy* / Q000517:prevention & control; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D053139:Oseltamivir; D017410:Practice Guidelines as Topic; D011714:Pyrans / Q000008:administration & dosage; D012307:Risk Factors; D012794:Sialic Acids / Q000008:administration & dosage; D053243:Zanamivir
D000081:Acetamides; D000998:Antiviral Agents; D006146:Guanidines; D007252:Influenza Vaccines; D011714:Pyrans; D012794:Sialic Acids; D053139:Oseltamivir; D000547:Amantadine; D009439:Neuraminidase; D053243:Zanamivir