Multiple tracheobronchial mucosal lesions in two cases of Churg-Strauss syndrome.
Churg-Strauss syndrome (CSS) is characterized by hypereosinophilia and a systemic necrotizing vasculitis seen almost exclusively in patients with asthma. The most common pathological findings in the chest in CSS are eosinophilic pneumonia, necrotizing vasculitis and granulomatous inflammation (extravascular granuloma). However, tracheobronchial mucosal lesions have rarely been reported in CSS. The authors report two patients with CSS who had multiple tracheobronchial mucosal lesions that were found by fibreoptic bronchoscopy. They were tiny nodular lesions and necrotizing bronchial inflammation with many eosinophils was observed upon pathological examination. The authors concluded that tracheobronchial mucosal lesions may be one of the manifestations of vasculitis seen in CSS.
Matsushima
Hidekazu
H
Department of Internal Medicine, Saitama Red Cross Hospital, Japan. himatsushima@sunny.ocn.ne.jp
Takayanagi
Noboru
N
Kurashima
Kazuyoshi
K
Tokunaga
Daido
D
Ubukata
Mikio
M
Kawabata
Yoshinori
Y
Sugita
Yutaka
Y
D000328:Adult; D001980:Bronchi / Q000473:pathology*; D001999:Bronchoscopy; D015267:Churg-Strauss Syndrome / Q000473:pathology*; D005336:Fiber Optic Technology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020545:Respiratory Mucosa / Q000473:pathology*; D014132:Trachea / Q000473:pathology*