title: The safety of nickel containing dental alloys.
abstract: Nickel is a constituent of many dental alloys. This paper reviews mainly papers published after 1985 with regards to biological reactions to nickel in dentistry. Nickel is an allergen, but there is no evidence that individual patients are at a significant risk of developing sensitivity solely due to contact with nickel-containing dental appliances and restorations. Hypersensitivity reactions to nickel are only likely to occur with prior sensitization from non-dental contacts and even these are rare. Clinical evidence has been presented to show that small doses of nickel, e.g. from dental appliances, may induce tolerance to this allergen. The papers reviewed report low rates of release of nickel from dental alloys. Some nickel compounds, which are mildly cytotoxic, have been implicated as carcinogens by inhalation in industrial settings, but these compounds are not present in dentistry-related operations, including dental technology procedures. Nickel-containing alloys and compounds have not been associated with increased cancer risk by oral or dermal routes of exposure. It is concluded that, subject to use according to established techniques, nickel-containing dental alloys do not pose a risk to patients or members of the dental team.
authors.affiliation: Restorative Dentistry, University of Manchester, UK.
authors.forename: James C
authors.initials: JC
authors.lastname: Setcos
authors.forename: Amir
authors.initials: A
authors.lastname: Babaei-Mahani
authors.forename: Lucy Di
authors.initials: LD
authors.lastname: Silvio
authors.forename: Ivar A
authors.initials: IA
authors.lastname: Mjör
authors.forename: Nairn H F
authors.initials: NH
authors.lastname: Wilson
mesh_terms: D002273:Carcinogens; D003257:Consumer Product Safety; D003343:Corrosion; D003722:Dental Alloys / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology; D009532:Nickel / Q000633:toxicity*; D009967:Orthodontic Appliances / Q000009:adverse effects
chemical_list: D002273:Carcinogens; D003722:Dental Alloys; D009532:Nickel