NFAT transcription factors--new players in the pathogenesis of inflammatory arthropathies?
Inflammatory arthropathies are characterized by major changes in gene expression, which-ultimately-result from differential activities of intracellular signaling pathways and their associated inducible transcription factors. The nuclear factor of activated T cells' (NFAT) family of transcription factors plays diverse roles in a variety of processes in the immune system and other tissues. Preliminary evidence has recently emerged implicating NFAT family members directly in the pathogenesis of inflammatory arthropathies. Specific anti-NFAT drug therapy may add to the pharmacologic armamentarium against rheumatoid arthritis, other inflammatory arthropathies, and related autoimmune disorders.
Pessler
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Department of Pediatrics, Division of Rheumatology, The Children's Hospital of Philadelphia, 3405 Civic Center Boulevard, Philadelphia, PA 19104, USA. pessler@email.chop.edu
Dai
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Schumacher
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D018501:Antirheumatic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D016572:Cyclosporine / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D008264:Macrophages / Q000378:metabolism; D008954:Models, Biological; D050778:NFATC Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*
D018501:Antirheumatic Agents; D016207:Cytokines; D050778:NFATC Transcription Factors; D016572:Cyclosporine