title: Does dexamethasone improve the quality of intravenous regional anesthesia and analgesia? A randomized, controlled clinical study.
abstract: We investigated the anesthetic and analgesic effectiveness of adding dexamethasone to lidocaine for IV regional anesthesia (IVRA). Seventy-five patients undergoing ambulatory hand surgery were randomly assigned to one of three groups: group L received 3 mg/kg lidocaine, group LD received 3 mg/kg lidocaine + 8 mg dexamethasone, and group LDc received 3 mg/kg lidocaine for IVRA and 8 mg dexamethasone IV to the nonsurgical arm. IVRA was established using 40 mL of a solution. Visual analog scale and verbal pain scores were recorded intraoperatively and for 2 h postoperatively. Postoperative pain was treated with oral acetaminophen 500 mg every 4 h when visual analog scale score was more than 3. Time to request for the first analgesic and the total dose in the first 24 h were noted. Times to onset of complete sensory and motor block were similar in the 3 groups. The times to recovery of motor block (L = 8 [5.91-10.08] min, LD = 13 [6.76-20.19] min, LDc = 6 [4.44-8.43] min) and sensory block (L = 7 [5.21-10.30] min, LD = 12 [6.11-19.40] min and LDc = 6 [4.2-8.11] min) were longer in group LD (P < 0.05). Patients in group LD reported significantly lower pain scores and required less acetaminophen in the first 24 h after surgery. In conclusion, the addition of 8 mg dexamethasone to lidocaine for IVRA in patients undergoing hand surgery improves postoperative analgesia during the first postoperative day.
authors.affiliation: Department of Anesthesiology, Akdeniz University Medical Faculty, Antalya, Turkey. zekiyebigat@hotmail.com
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Bigat
authors.forename: Neval
authors.initials: N
authors.lastname: Boztug
authors.forename: Necmiye
authors.initials: N
authors.lastname: Hadimioglu
authors.forename: Nihan
authors.initials: N
authors.lastname: Cete
authors.forename: Nesil
authors.initials: N
authors.lastname: Coskunfirat
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Ertok
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D000765:Anesthesia, Conduction; D000771:Anesthesia, Intravenous; D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002349:Carpal Tunnel Syndrome / Q000601:surgery; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000759:Adjuvants, Anesthesia; D000700:Analgesics; D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D008012:Lidocaine