title: The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.
abstract: Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.
authors.affiliation: Department of Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: J Matthew
authors.initials: JM
authors.lastname: McDonald
authors.forename: Sarah
authors.initials: S
authors.lastname: Dunlap
authors.forename: David
authors.initials: D
authors.lastname: Cogdell
authors.forename: Valerie
authors.initials: V
authors.lastname: Dunmire
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Wei
authors.forename: Anna
authors.initials: A
authors.lastname: Starzinski-Powitz
authors.forename: Raymond
authors.initials: R
authors.lastname: Sawaya
authors.forename: Janet
authors.initials: J
authors.lastname: Bruner
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Fuller
authors.forename: Kenneth
authors.initials: K
authors.lastname: Aldape
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D002465:Cell Movement; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D018895:Microsatellite Repeats; D009154:Mutation; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology*; D016133:Polymerase Chain Reaction; D014162:Transfection
chemical_list: C483313:AJAP1 protein, human; D015815:Cell Adhesion Molecules; D008565:Membrane Proteins