title: Splenic small B-cell lymphoma with IGH/BCL3 translocation.
abstract: Isolated chromosomal translocations are important defining features of many non-Hodgkin lymphomas, especially of B-cell type. In contrast to some other translocations, the significance of IGH/BCL3 translocations is not well defined. Although often considered a feature of the ill-defined entity atypical chronic lymphocytic leukemia, very few cases are reported in which involvement of BCL3 and the precise B-cell neoplasm are both well documented. For this reason, we report a splenic-based CD5(-), CD10(-), CD43(-), CD23(-), CD103(-), FMC7(+), CD25(+) small B-cell lymphoma associated with epithelioid histiocyte clusters and a t(14;19)(q32;q13) representing an IGH/BCL3 translocation based on classical cytogenetic studies, chromosomal painting, and fluorescence in situ hybridization studies. The previously reported neoplasms with t(14;19)(q32;q13) or IGH/BCL3 translocations are also reviewed. The present case did not fall into any of the classic B-cell lymphoma categories and clearly did not represent chronic lymphocytic leukemia/small lymphocytic lymphoma. This case suggests that the IGH/BCL3 translocation may help to define a new clinicopathologic entity.
authors.affiliation: Division of Hematopathology, University of Pittsburgh School of Medicine, PA 15213, USA.
authors.forename: Lorinda A
authors.initials: LA
authors.lastname: Soma
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Gollin
authors.forename: Ellen D
authors.initials: ED
authors.lastname: Remstein
authors.forename: Rhett P
authors.initials: RP
authors.lastname: Ketterling
authors.forename: Heather C
authors.initials: HC
authors.lastname: Flynn
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Rajasenan
authors.forename: Steven H
authors.initials: SH
authors.lastname: Swerdlow
mesh_terms: D000368:Aged; D000081242:B-Cell Lymphoma 3 Protein; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D013154:Spleen / Q000473:pathology; D013160:Splenic Neoplasms / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; D007143:Immunoglobulin Heavy Chains; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors