[CD117 contribution in the diagnosic of mesenchymal tumors of the digestive tract].
Gastrointestinal stromal tumor (GIST) is a new distinct entity defined as CDI 17 or c-kit positive mesenchymal tumors, originaling in gastrointestinal pacemaker cells known as interstitial cells of Cajal. This study evaluate the percentage of GIST previously diagnosed as mesenchymal tumors in our hospital during 11 years.


METHODS
A total of 30 surgically resected gastrointestinal tumor specimens were collected from January 1990 to December 2000 in the pathology laboratory of la Rabta Jospital. Immunohistochemical studies were performed on these tumors with antibodies of CD 117, smooth muscle actin (SMA) and protein S-100.


RESULTS
Among the 30 tumors, 26 (86.6%) were CD117 positive and were classified as gastrointestinal stromal tumors. Among the 26 GIST, SMA was positive in 11 tumors (42.3%), 6 tumors (23%) expressed protein S-100. The 4 tumors classified as non-GIST were leiomyomas with the following immunohistochemical characteristics: CD117-negative with strong SMA-positive and protein S100 negative status.


CONCLUSIONS
The majority (86.6%) of mesenchymal gastrointestinal tumors were GIST, except for a smalls groups of smooth muscle tumors.
Khadija
Bellil
B
Service d'anatomie pathologique, hôpital la Rabta, 1007 Bab Saadoun, Tunis, Tunisie.
Saadia
Bouraoui
B
Ines
Chelly
C
Sami
Karoui
K
Mohamed
Jouini
J
Zina
Chikhaoui
C
Nidhammeddine
Kchir
K
Mohamed
M Zitouna
MZ
Slim
Haouet
H
D000199:Actins / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000473:pathology; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000175:diagnosis / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis*; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis
D000199:Actins; D014408:Biomarkers, Tumor; D009418:S100 Proteins; D019009:Proto-Oncogene Proteins c-kit