Clinical trial recruitment and retention of a vulnerable population: HIV patients with chronic diarrhea.
This article describes the recruitment and retention strategies implemented for a prospective, randomized, clinical trial conducted at a single study facility. The purpose of the study was to examine the effects of a nutritional intervention to reduce the episodes of diarrhea in patients with the human immunodeficiency virus/acquired immune deficiency syndrome. This article reviews the challenges faced by the research team during the conduct of the study and discusses the approaches implemented to reduce the barriers to study participation.
Anastasi
Joyce K
JK
Clinical Nursing, Columbia University School of Nursing, New York, New York 10032, USA. jka8@columbia.edu
Capili
Bernadette
B
Kim
Gee H
GH
Chung
Ann
A
D000328:Adult; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000178:diet therapy*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D009519:New York City; D018579:Patient Selection; D035862:Vulnerable Populations