Meta-analysis of association of rare mutations and common sequence variants in the MSR1 gene and prostate cancer risk.
BACKGROUND
MSR1 has been reported to be associated with increased risk of prostate cancer (PCa).


METHODS
We performed a meta-analysis of all eight published studies to evaluate the pooled effect of three rare mutations (R293X, S41T, and D174Y) and five common sequence variants (PRO3, INDEL1, IVS5-59, P275A, and INDEL7), stratified by race and sporadic/hereditary cancer.


RESULTS
Several variants were significantly or marginally significantly associated with sporadic, not hereditary PCa risk, including R293X in white men (random effect OR = 1.34, P = 0.09) and D174Y in black men (random effect OR = 2.41, P = 0.04). The associations were not significant when the initial study was excluded. However, the frequency of the D174Y mutation was consistently higher among cases in all three studies that examined black men.


CONCLUSIONS
Overall, this meta-analysis suggests the MSR1 gene does not independently confer a major risk to PCa but may confer a moderate risk to PCa, especially in black men.
Sun
Jielin
J
Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Hsu
Fang-Chi
FC
Turner
Aubrey R
AR
Zheng
S Lilly
SL
Chang
Bao-Li
BL
Liu
Wennuan
W
Isaacs
William B
WB
Xu
Jianfeng
J
D001741:Black or African American / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000235:genetics*; D012307:Risk Factors; D051117:Scavenger Receptors, Class A / Q000235:genetics*
C495139:MSR1 protein, human; D051117:Scavenger Receptors, Class A