Can modulating corticotropin releasing hormone receptors alter visceral sensitivity?
Activation of corticotropin releasing hormone (CRH) receptor 2 (CRH-R2) reduces visceral sensitivity induced by colorectal distension in conscious rats. This finding is relevant to the increased interest in the potential use of therapeutic agents that act on CRH receptors in the treatment of irritable bowel syndrome.
Fukudo
S
S
Department of Behavioural Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. sfukudo@mail.tains.tohoku.ac.jp
Saito
K
K
Sagami
Y
Y
Kanazawa
M
M
D000818:Animals; D007420:Intestine, Large / Q000503:physiopathology*; D043183:Irritable Bowel Syndrome / Q000209:etiology / Q000503:physiopathology; D008297:Male; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*
D018019:Receptors, Corticotropin-Releasing Hormone