Induction of CITED2 expression in the rat hippocampus following transient global ischemia.
CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen-glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.
Sun
Woong
W
Department of Anatomy and Division of Brain Korea 21 Biomedical Science, College of Medicine, Korea University, 126-1 Anam-Dong, Sungbuk-Gu, Seoul, South Korea.
Kim
Kye-Hyun
KH
Noh
Mira
M
Hong
Soontaek
S
Huh
Pil Woo
PW
Kim
Younghwa
Y
Kim
Hyun
H
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology / Q000503:physiopathology; D017362:Cyclic AMP Response Element-Binding Protein / Q000096:biosynthesis*; D017931:DNA Primers; D006624:Hippocampus / Q000502:physiology* / Q000503:physiopathology; D051793:Hypoxia-Inducible Factor 1 / Q000096:biosynthesis; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D051381:Rats; D012097:Repressor Proteins / Q000096:biosynthesis*; D015534:Trans-Activators / Q000096:biosynthesis*; D014158:Transcription, Genetic
D017362:Cyclic AMP Response Element-Binding Protein; D017931:DNA Primers; D051793:Hypoxia-Inducible Factor 1; D012097:Repressor Proteins; D015534:Trans-Activators