Cartilage hair hypoplasia and multiple basal cell carcinomas.
Cartilage hair hypoplasia (CHH) is an autosomal recessively inherited syndrome characterized by short stature, sparse hair, and immunodeficiency. An increased incidence of malignancy has been reported in this condition, but basal cell carcinoma and CHH has not previously been reported in the dermatology literature. We report the case of a 25-year-old woman with CHH and multiple basal cell carcinomas. A causal relationship is conceivable and, therefore, for patients with CHH, dermatologists should be aware of a possible increased risk of basal cell carcinomas.
Eisner
Jodi M
JM
Department of Dermatology, University of Virginia, Charlottesville, Virginia 22908, USA.
Russell
Mark
M
D000328:Adult; D002280:Basal Cell Carcinoma / Q000150:complications*; D005260:Female; D006197:Hair / Q000473:pathology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D009378:Neoplasms, Multiple Primary / Q000150:complications; D010009:Osteochondrodysplasias / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications*