title: Efficacy of Citrus reticulata and Mirazid in treatment of Schistosoma mansoni.
abstract: This work has been carried out to investigate the effect of Schistosoma mansoni infection on mice livers after treatment with the ethanolic extract of Citrus reticulata root or the oleo-resin extract from Myrrh of Commiphora molmol tree (Mirazid), as a new antishistosomal drug. Marker enzymes for different cell organelles were measured; succinate dehydrogenase (SDH); lactate dehydrogenase (LDH) and its isoenzymes; glucose-6-phosphatase (G-6-Pase); acid phosphatase (AP) and 5'- nucleotidase. Liver function enzymes; aspartate aminotransferase (AST); alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were also estimated. Parasitological studies through ova count and worm burden will also be taken into consideration. The results showed a marked reduction in SDH, LDH, AST, and ALT enzyme activities and a significant increase in G-6-Pase, AP, 5'- nucleotidase, and ALP after S. mansoni infection. A noticeable alteration in LDH subunits were also noticed. Treatment with C. reticulata or Mirazid improved all the previous enzyme activities with a noticeable reduction in ova count and worm burden.
authors.affiliation: Department of Medicinal Chemistry, National Research Centre, Dokki, Cairo, Egypt. manal_hamed@yahoo.com
authors.forename: Manal A
authors.initials: MA
authors.lastname: Hamed
authors.forename: Mona H
authors.initials: MH
authors.lastname: Hetta
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002957:Citrus; D029744:Commiphora; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000201:enzymology / Q000469:parasitology; D008297:Male; D051379:Mice; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000201:enzymology; D012556:Schistosomicides / Q000627:therapeutic use*; D013729:Terpenes / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D010936:Plant Extracts; D012556:Schistosomicides; D013729:Terpenes; C014119:myrrh oil