title: Release of mitochondrial DNA fragments from brain mitochondria of irradiated mice.
abstract: Recently, we demonstrated that the release of mtDNA fragments from mitochondria occurs as a result of the opening of a non-specific pore in the inner mitochondrial membrane. Here, we show that irradiation of mice stimulates the appearance of mtDNA fragments in the cytosolic fractions of the brain. The fragments of mtDNA were found as early as 1h after irradiation, when no observable alteration of mitochondrial functioning occurred. The involvement of mitochondrial permeability transition in this process is discussed.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Pushchino 142290, Russian Federation.
authors.forename: Maxim
authors.initials: M
authors.lastname: Patrushev
authors.forename: Vitaliy
authors.initials: V
authors.lastname: Kasymov
authors.forename: Valeria
authors.initials: V
authors.lastname: Patrusheva
authors.forename: Tatiana
authors.initials: T
authors.lastname: Ushakova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gogvadze
authors.forename: Azhub I
authors.initials: AI
authors.lastname: Gaziev
mesh_terms: D000818:Animals; D001921:Brain / Q000528:radiation effects*; D001923:Brain Chemistry; D003600:Cytosol / Q000737:chemistry; D004272:DNA, Mitochondrial / Q000032:analysis / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008928:Mitochondria / Q000235:genetics / Q000528:radiation effects*
chemical_list: D004272:DNA, Mitochondrial