title: Comparison of hemodynamic, clinicopathologic, and gastrointestinal motility effects and recovery characteristics of anesthesia with isoflurane and halothane in horses undergoing arthroscopic surgery.
abstract: OBJECTIVE
  To compare hemodynamic, clinicopathologic, and gastrointestinal motility effects and recovery characteristics of halothane and isoflurane in horses undergoing arthroscopic surgery.
  
  
  METHODS
  8 healthy adult horses.
  
  
  METHODS
  Anesthesia was maintained with isoflurane or halothane (crossover study). At 6 intervals during anesthesia and surgery, cardiopulmonary variables and related derived values were recorded. Recovery from anesthesia was assessed; gastrointestinal tract motility was subjectively monitored for 72 hours after anesthesia. Horses were administered chromium, and fecal chromium concentration was used to assess intestinal transit time. Venous blood samples were collected for clinicopathologic analyses before and 2, 24, and 48 hours after anesthesia.
  
  
  RESULTS
  Compared with halothane-anesthetized horses, cardiac index, oxygen delivery, and heart rate were higher and systemic vascular resistance was lower in isoflurane-anesthetized horses. Mean arterial blood pressure and the dobutamine dose required to maintain blood pressure were similar for both treatments. Duration and quality of recovery from anesthesia did not differ between treatments, although the recovery periods were somewhat shorter with isoflurane. After isoflurane anesthesia, gastrointestinal motility normalized earlier and intestinal transit time of chromium was shorter than that detected after halothane anesthesia. Compared with isoflurane, halothane was associated with increases in serum aspartate transaminase and glutamate dehydrogenase activities, but there were no other important differences in clinicopathologic variables between treatments.
  
  
  CONCLUSIONS
  Compared with halothane, isoflurane appears to be associated with better hemodynamic stability during anesthesia, less hepatic and muscle damage, and more rapid return of normal intestinal motility after anesthesia in horses undergoing arthroscopic procedures.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
authors.forename: Sumit
authors.initials: S
authors.lastname: Durongphongtorn
authors.forename: Wayne N
authors.initials: WN
authors.lastname: McDonell
authors.forename: Carolyn L
authors.initials: CL
authors.lastname: Kerr
authors.forename: Francisco J Teixeira
authors.initials: FJ
authors.lastname: Neto
authors.forename: Kuldip K
authors.initials: KK
authors.lastname: Mirakhur
mesh_terms: D000704:Analysis of Variance; D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D001182:Arthroscopy / Q000662:veterinary*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology*; D006334:Heart Function Tests / Q000187:drug effects*; D006736:Horses / Q000502:physiology*; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D012123:Pulmonary Ventilation / Q000187:drug effects*
chemical_list: D007530:Isoflurane; D006221:Halothane