Diagnosis and management of heterokaryotypic monochorionic twins.
The diagnosis, management, and outcome of six consecutive heterokaryotypic monochorionic twins were evaluated. All suspected cases, based on discordant ultrasound findings, underwent amniocentesis of both sacs. Two cases also had chorionic villous sampling (CVS). Dual amniocentesis was superior to CVS in diagnosing heterokaryotypic monochorionic twins. In four cases, the X-chromosome was involved and autosomal aneuploidy was noted in the others. In five cases, the anomalous twin was selectively reduced by cord coagulation. All pregnancies ended with a phenotypically normal liveborn and all children are developing normally at 1-7 years of age.
Lewi
Liesbeth
L
Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium.
Blickstein
Isaac
I
Van Schoubroeck
Dominique
D
Gloning
Karl-Philipp
KP
Casteels
Martine
M
Brandenburg
Helen
H
Fryns
Jean-Pierre
JP
Deprest
Jan
J
D000328:Adult; D000649:Amniocentesis; D002648:Child; D002675:Child, Preschool; D004200:Diseases in Twins / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal / Q000379:methods*; D014430:Twins, Monozygotic