Human tumor necrosis factor is a chemoattractant for the parasite Entamoeba histolytica.
In an analysis of the molecular factors triggering amebiasis, we investigated the chemotaxis of Entamoeba histolytica toward tumor necrosis factor (TNF) in vitro, using quantitative imaging techniques. Our findings enabled us to propose a hitherto unknown role for TNF as a chemokinetic and chemoattractant agent for this parasite.
Blazquez
Samantha
S
Cell Biology of Parasitism Unit, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
Zimmer
Christophe
C
Guigon
Ghislaine
G
Olivo-Marin
Jean-Christophe
JC
Guillén
Nancy
N
Labruyère
Elisabeth
E
D000818:Animals; D002630:Chemotactic Factors / Q000502:physiology*; D002633:Chemotaxis; D004748:Entamoeba histolytica / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D002630:Chemotactic Factors; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha