Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice.
We have studied the effect of muscular dystrophy by merosin deficiency on mouse thymus acetyl- (AChE) and butyrylcholinesterase (BuChE). The organ contains AChE and BuChE activities. Merosin deficiency causes an important decrease (46%) in AChE specific activity. Thymus produces dimers, monomers and tetramers of AChE, and the three kinds of AChE mRNAs. The drop in AChE activity in dystrophic animals could affect the amount of ACh reaching cholinergic receptors in cells of lymphoid organs.
Sánchez del Campo
L
L
Dpto. de Bioquímica y Biología Molecular-A, Universidad de Murcia, Spain.
Nieto-Cerón
S
S
Muñoz-Delgado
E
E
Vidal
C J
CJ
Campoy
F J
FJ
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D007797:Laminin / Q000172:deficiency* / Q000235:genetics; D051379:Mice; D009137:Muscular Dystrophy, Animal / Q000201:enzymology* / Q000378:metabolism; D013950:Thymus Gland / Q000201:enzymology*
D007797:Laminin; C102645:laminin alpha 2; D000110:Acetylcholinesterase