title: A tighter RVxF motif makes a finer Sift.
abstract: Most partners of protein phosphatase 1 rely on an instance of the so-called RVxF motif for interaction with the enzyme. In this issue of Chemistry & Biology, a stringent definition of the motif targeting high-affinity instances enabled Meiselbach and colleagues to recognize novel binding partners with high specificity .
authors.affiliation: Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Belgium.
authors.forename: Hugo
authors.initials: H
authors.lastname: Ceulemans
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bollen
mesh_terms: D020816:Amino Acid Motifs; D001665:Binding Sites; D010749:Phosphoprotein Phosphatases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D054645:Protein Phosphatase 1; D013379:Substrate Specificity
chemical_list: D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1