title: Articaine is more effective than lidocaine or mepivacaine in rat sensory nerve conduction block in vitro.
abstract: The reasons for the relatively high failure rate after inferior alveolar nerve block in dentistry are not fully understood. Therefore, the effectiveness of different anesthetic solutions (2% and 4% lidocaine, 3% mepivacine, 2% and 4% articaine) in depressing the compound action potential amplitude of the sensory fibers in the rat sural nerve was examined under strictly controlled conditions in vitro. After application of an anesthetic solution and stimulation of the nerve with a supramaximal electrical stimulus, a complete disappearance of the compound action potential of the C fibers, but not of the A fibers, was observed in all the experimental groups. Both 2% and 4% articaine more effectively depressed the compound action potential of the A fibers than did other anesthetic solutions. These results are discussed in the light of recent clinical reports finding no differences in the effectiveness between 4% articaine and 2% lidocaine regarding the inferior alveolar nerve block.
authors.affiliation: Department of Restorative Dentistry & Endodontics, University of Ljubljana, Dental School, Hrvatski trg 6,1000 Ljubljana, Slovenia. igor.potocnik@mf.uni-lj.si
authors.forename: I
authors.initials: I
authors.lastname: Potocnik
authors.forename: M
authors.initials: M
authors.lastname: Tomsic
authors.forename: J
authors.initials: J
authors.lastname: Sketelj
authors.forename: F F
authors.initials: FF
authors.lastname: Bajrovic
mesh_terms: D000200:Action Potentials; D000704:Analysis of Variance; D000779:Anesthetics, Local; D000818:Animals; D002355:Carticaine; D008012:Lidocaine; D008297:Male; D008619:Mepivacaine; D009407:Nerve Block / Q000379:methods*; D009413:Nerve Fibers, Myelinated; D036421:Nerve Fibers, Unmyelinated; D051381:Rats; D017208:Rats, Wistar; D013497:Sural Nerve
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D008619:Mepivacaine; D002355:Carticaine