title: About a case of GIST occurring during pregnancy with immunohistochemical expression of epidermal growth factor receptor and progesterone receptor.
abstract: The coexistence of gastrointestinal stromal tumors (GISTs) and pregnancy is very rare. We are the first to add to the literature a case report of GIST occurring during pregnancy with immunohistochemical staining for epidermal growth factor receptor (EGFR) and progesterone receptor (PgR). A role of PgR and EGFR in tumor growth should not be excluded, and these findings indicate that the expression of these receptors could provide pertinent biological information required to determine adequate therapeutic regimens. In conclusion, considering that GIST occurring during pregnancy is a rare event, with frequent delay in diagnosis, it is important to consider this diagnosis for early recognition, correct diagnosis, and a better outcome.
authors.affiliation: Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Santa Sofia 87 Street, 95123 Catania, Italy. lanzafas@unict.it
authors.forename: S
authors.initials: S
authors.lastname: Lanzafame
authors.forename: V
authors.initials: V
authors.lastname: Minutolo
authors.forename: R
authors.initials: R
authors.lastname: Caltabiano
authors.forename: O
authors.initials: O
authors.lastname: Minutolo
authors.forename: B
authors.initials: B
authors.lastname: Marino
authors.forename: G
authors.initials: G
authors.lastname: Gagliano
authors.forename: S
authors.initials: S
authors.lastname: D'Asta
mesh_terms: D000328:Adult; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis*; D011374:Progesterone / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
chemical_list: D011980:Receptors, Progesterone; D011374:Progesterone; D004815:Epidermal Growth Factor; D066246:ErbB Receptors