title: Single-institution experience in the management of patients with clinical stage I and II cutaneous melanoma: results of sentinel lymph node biopsy in 240 cases.
abstract: BACKGROUND
  Lymphatic mapping and sentinel lymph node biopsy (SLNB) has been developed as a minimally invasive technique to determine the pathologic status of regional lymph nodes in patients without clinically palpable disease and incorporated in the latest version of the American Joint Committee on Cancer (AJCC) staging system for cutaneous melanoma.
  
  
  OBJECTIVE
  To analyze the results of SLNB and the prognostic value of the micrometastases and the pattern of early recurrences in patients according to sentinel lymph node (SLN) status.
  
  
  METHODS
  Patients with cutaneous melanoma in stages I and II (AJCC 2002) who underwent lymphatic mapping and SLNB from 1997 to 2003 were included in a prospective database for analysis.
  
  
  RESULTS
  The rate of identification of the SLN was 100%. Micrometastases to SLN were found in 20.8% of patients. The rate of SLN micrometastases increased according to Breslow thickness and clinical stage. Breslow thickness of 0.99 mm was the optimal cutpoint for predicting the SLNB result. Twenty-four patients (12.3%) developed a locoregional or distant recurrence at a median follow-up of 31 months. Recurrences were more frequent in patients with a positive SLN. Among patients who had a recurrence, those with a positive SLN were more likely to have distant metastases than those with negative SLN. Nodal recurrences were more frequent in patients with a negative SLN compared with those with a positive SLN.
  
  
  CONCLUSIONS
  The status of the SLN provides accurate staging for identifying patients who may benefit from further therapy and is the most important prognostic factor of relapse-free survival.
authors.affiliation: Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Badalona, Spain. 32262jrc@comb.es
authors.forename: Jordi
authors.initials: J
authors.lastname: Rex
authors.forename: Cristina
authors.initials: C
authors.lastname: Paradelo
authors.forename: Cristina
authors.initials: C
authors.lastname: Mangas
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Hilari
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Fernández-Figueras
authors.forename: Manel
authors.initials: M
authors.lastname: Fraile
authors.forename: Antoni
authors.initials: A
authors.lastname: Alastrué
authors.forename: Carlos
authors.initials: C
authors.lastname: Ferrándiz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018579:Patient Selection; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology*; D018709:Statistics, Nonparametric; D016019:Survival Analysis