title: Increased use of mental health services related to isotretinoin treatment: a 5-year analysis.
abstract: BACKGROUND
  The association between exposure to Isotretinoin, the development of depression and suicide attempts is controversial.
  
  
  OBJECTIVE
  To retrospectively assess pattern of utilization of mental health services in the Israeli Defense Forces (IDF) during a 5-year period for all subjects exposed to Isotretinoin in comparison to a control group consisting of army conscripts suffering from psoriasis. All subjects were young adults (18 to 21 years old) in compulsory military service.
  
  
  METHODS
  Exposure to Isotretinoin mandates reporting and marking as a coded medical profile in the IDFs' computerized medical record of each conscript and soldier. Medical data, tracked by military medical profiles, were summarized from medical records of all subjects treated by Isotretinion during the years 1999-2003 and for the control group for the same period. Use of mental health services was the a-priori defined primary outcome measure.
  
  
  RESULTS
  During the study period 1419 subjects were exposed to Isotretinoin and 1102 suffered from psoriasis. Utilization of mental health services was highest for the index group wherein 17.2% (245/1419) of subjects were evaluated or treated compared to 12.5% in the control group (psoriasis). The inter-group differences were statistically significant; Chi-square=15.9 (df=2), p=0.0003.
  
  
  CONCLUSIONS
  We suggest that psychiatric evaluation be regularly undertaken prior to initiation of Isotretinion treatment in young adults at risk, as well as providing follow-up visits during and at completion of treatment.
authors.affiliation: Medical Corps, IDF, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Friedman
authors.forename: Yonit
authors.initials: Y
authors.lastname: Wohl
authors.forename: Haim Y
authors.initials: HY
authors.lastname: Knobler
authors.forename: Gadi
authors.initials: G
authors.lastname: Lubin
authors.forename: Sarah
authors.initials: S
authors.lastname: Brenner
authors.forename: Yehezkel
authors.initials: Y
authors.lastname: Levi
authors.forename: Yoram
authors.initials: Y
authors.lastname: Barak
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D000293:Adolescent; D000328:Adult; D005260:Female; D006296:Health Services / Q000706:statistics & numerical data / Q000639:trends; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D007557:Israel; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced / Q000453:epidemiology; D008605:Mental Health Services / Q000706:statistics & numerical data* / Q000639:trends*; D008889:Military Personnel / Q000523:psychology; D011565:Psoriasis / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D012189:Retrospective Studies
chemical_list: D015474:Isotretinoin