title: A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions.
abstract: A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show antiproliferative activities similar to discodermolide.
authors.affiliation: Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA. shaw@kosan.com
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Shaw
authors.forename: Kurt F
authors.initials: KF
authors.lastname: Sundermann
authors.forename: Mark A
authors.initials: MA
authors.lastname: Burlingame
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Joseph
authors.initials: J
authors.lastname: Petryka
authors.forename: David C
authors.initials: DC
authors.lastname: Myles
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D007783:Lactones; D014315:Triterpenes; C478086:23,24-dihydrocucurbitacin B