TrwB: an F(1)-ATPase-like molecular motor involved in DNA transport during bacterial conjugation.
The mechanism by which TrwB acts as a DNA transporter in bacterial conjugation is analyzed. Based on a parallelism between TrwB and F(1)-ATPase, TrwB would use the energy derived from ATP hydrolysis to pump DNA through its central channel, in a manner similar to that used by F(1)-ATPase to produce a rotary movement of the central gamma-subunit.
Cabezon
Elena
E
Departamento de Biología Molecular (Unidad Asociada al CIB-CSIC), Universidad de Cantabria, C. Herrera Oria s/n, 39011 Santander, Spain.
de la Cruz
Fernando
F
D000251:Adenosine Triphosphatases / Q000502:physiology*; D001692:Biological Transport; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology*; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000502:physiology*
D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D020409:Molecular Motor Proteins; C403125:trwB protein, E coli; D000251:Adenosine Triphosphatases