Abdominal Castleman disease with mixed histopathology in a patient with iron deficiency anemia, growth retardation and peliosis hepatis.
In Castleman disease, also known as giant lymph node hyperplasia, lesions are usually located in the chest. Peliosis hepatis is the presence of multiple blood-filled cysts in the liver. The combination of these two disorders in one patient is rare, with only three cases reported to date. We report the case of a 21-year-old man who presented with growth retardation and iron deficiency anemia. Work-up revealed hepatomegaly and multiple conglomerated giant lymph nodes near the splenic hilum. Once the mass was surgically removed, the patient's anemia rapidly resolved and he showed catch-up growth. The lymphoid tissue exhibited mixed histologic type, so the patient was diagnosed with both hyaline vascular type and plasma cell type Castleman disease. A liver biopsy obtained at surgery showed sinusoidal dilatation and blood-filled cysts, indicating peliosis hepatis. This is the fourth documented case of peliosis hepatis associated with Castleman disease. In addition to describing the case features, we discuss the possible pathogenesis of peliosis hepatis in the setting of Castleman disease.
Saritas
Ulku
U
Division of Gastroenterology, Ankara Numune Hospital, Turkey.
Ustundag
Yucel
Y
Isitan
Gokhan
G
Bastugrul
Settar
S
Erekul
Selim
S
D000005:Abdomen / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000150:complications*; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006130:Growth Disorders / Q000150:complications*; D006801:Humans; D010382:Peliosis Hepatis / Q000150:complications*; D014463:Ultrasonography