title: Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo.
abstract: Reactivation potency of three newly developed oximes K027, K033 and K048 was tested using standard in vitro and in vivo reactivation tests. K027 and K048 seem to be efficacious reactivators of tabun-inhibited acetylcholinesterase. K033 is sufficient reactivator of cyclosarin-inhibited AChE. However, its potency is poor compared with current "gold standard" oxime HI-6.
authors.affiliation: Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Lucie
authors.initials: L
authors.lastname: Bartosova
authors.forename: Jiri
authors.initials: J
authors.lastname: Kassa
authors.forename: Jiri
authors.initials: J
authors.lastname: Cabal
authors.forename: Jiri
authors.initials: J
authors.lastname: Bajgar
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kunesova
authors.forename: Daniel
authors.initials: D
authors.lastname: Jun
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D004789:Enzyme Activation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology*; D009498:Neurotoxins / Q000494:pharmacology* / Q000633:toxicity; D010091:Oximes / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D009498:Neurotoxins; D010091:Oximes; D000110:Acetylcholinesterase