Interleukin-8 CSF levels predict survival in patients with leptomeningeal metastases.
Median survival of patients with leptomeningeal metastases (LM) is 4 to 6 months, with a few long-term survivors. Current prognostic factors for survival have limited value. The authors measured the CSF levels of nine inflammatory proteins in 57 patients with LM and determined their prognostic value. High interleukin (IL)-8 CSF levels predicted short-term survival independently. The data indicate that IL-8 CSF levels may serve as a prognosticator in patients with LM, but prospective validation is needed.
Brandsma
D
D
Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands. d.brandsma@umcutrecht.nl
Taphoorn
M J B
MJ
de Jager
W
W
Bonfrer
H
H
Algra
A
A
Reijneveld
J C
JC
Boogerd
W
W
Korse
T
T
Verbeek
M M
MM
Rijkers
G T
GT
Voest
E E
EE
D000328:Adult; D000368:Aged; D001099:Arachnoid; D005260:Female; D006801:Humans; D007118:Immunoassay; D016209:Interleukin-8 / Q000134:cerebrospinal fluid*; D008297:Male; D008577:Meningeal Neoplasms / Q000401:mortality / Q000503:physiopathology* / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D010841:Pia Mater; D011237:Predictive Value of Tests; D011379:Prognosis; D012737:Sex Factors; D016019:Survival Analysis; D017741:Survivors
D016209:Interleukin-8