[Human immunodeficiency virus, hepatitis C virus and hepatitis B viruses in patients with sickle-cell disease in Togo].
BACKGROUND
The clinical features of sickle cell disease (SCD) are vaso-occlusive and/or hemolytic crises which treatment may require blood transfusions.


OBJECTIVE
This study aimed to determine the prevalence of HIV, Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) infections in a population of SCD patients.


METHODS
All the samples were analyzed by Elisa technique. We studied 119 sera for HIV using Elisa and a confirmation test in case of positive Elisa. We screened 91 sera for HCV and 119 sera for HBV.


RESULTS
The prevalence was 5.04% for HIV, 6.5% for HCV and 20.2% for HBs Ag. Homozygous (SS) patients were more infected than compound heterozygous patients SC, (p < 0.02). 24.6% of the children (0 to 15 years of age) were infected as well as adults (35.5%). The Relative Risk to be contaminated was 7.14 for HIV, 4.29 for HCV and 5.43 for HBV in transfused compared to non transfused SCD patients.


CONCLUSIONS
This high infectious risk in SCD patients should lead us to elaborate a better strategy to increase the safety of blood transfusion in Togo.
Ségbéna
A-Y
AY
Département des sciences fondamentales et biologiques, faculté mixte de médecine et de pharmacie, université de Lomé, boulevard Eyadema, Togo. asegbena@tg.refer.org
Prince-David
M
M
Kagoné
T Samdapawindé
TS
Dagnra
A-Y
AY
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000097:blood* / Q000453:epidemiology*; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology*; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology*; D006720:Homozygote; D006801:Humans; D007223:Infant; D015995:Prevalence; D012306:Risk; D014037:Togo / Q000453:epidemiology; D065227:Transfusion Reaction