Second and third malignant solid tumor in a girl with ovarian Sertoli-Leydig tumor.
We report a Sertoli-Leydig cell (SLC) tumor of the right ovary in a 10-year-old girl, which was dealt with surgical removal. Three months after resection, she presented with a new episode of acute abdomen because of an abdominal mass, which histologically was compatible with an undifferentiated embryonal rhabdomyosarcoma. Chemotherapy, according to SIOP-??? 89 protocol, was administered additionally to radiotherapy (3,960 cGy). Three years after completing treatment, the patient developed a painful swelling at her left upper arm. The diagnosis was Ewing sarcoma of the humerus, which was confirmed by identification of the typical 11; 22 translocation on cytogenetic and molecular analysis of the tumor tissue. The patient died 14 months from Ewing diagnosis due to progressive disease.
Panagiotou
John P
JP
Department of Pediatric Hematology/Oncology, "Aghia Sophia" Children's Hospital, Athens, Greece. pepisofou@hotmail.com
Polychronopoulou
Sophia
S
Sofou
Kalliopi
K
Vanvliet-Constantinidou
Catherine
C
Papandreou
Evangelos
E
Haidas
Stavros
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D018310:Sertoli-Leydig Cell Tumor / Q000473:pathology*; D014178:Translocation, Genetic