Prognostic indicators in an aggressive pituitary Crooke's cell adenoma.
OBJECTIVE
To investigate prognostic indicators in an aggressive Crooke's cell adenoma of the pituitary.


METHODS
The surgically removed tumor was studied by histology, immunohistochemistry and transmission electron microscopy.


RESULTS
An aggressive invasive sellar tumor removed by repeated surgeries from a 43-year-old woman with pituitary related Cushing's disease was classified as a Crooke's cell adenoma of the pituitary. The application of several cell proliferation markers confirmed the aggressive nature of the tumor.


CONCLUSIONS
The investigation of the present case provides additional evidence that pituitary Crooke's cell adenomas may possess aggressive behavior.
Kovacs
K
K
Department of Laboratory Medicine and Pathobiology, St. Michaels Hospital, University of Toronto, Toronto, ON, Canada.
Diep
C C
CC
Horvath
E
E
Cusimano
M
M
Smyth
H
H
Lombardero
C Coire M
CC
Scheithauer
B W
BW
Lloyd
R V
RV
D000236:Adenoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003480:Cushing Syndrome / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D011379:Prognosis
D014408:Biomarkers, Tumor