[Pregnancy outcome in five women after autologous bone marrow transplantation for acute lymphoblastic leukaemia].
There are reports of successful pregnancies in women with haematological malignancies after either autologous or allogeneic bone marrow transplantation (BMT). We report six cases of uncomplicated pregnancies in five women treated with high-dose chemotherapy, radiotherapy and autologous bone marrow transplantation (ABMT) for acute lymphoblastic leukaemia. One patient was diagnosed as having leukaemia during pregnancy. The pregnancy ended with medical termination. Each woman received conditioning regimens without total body irradiation (TBI). Of five women, who received AMBT, all resumed spontaneous cyclical menstruation post transplantation. All of them conceived naturally between 15-52 months following ABMT. We noted one miscarriage in our 29-year-old patient. Six pregnancies went to term and each resulted in the successful delivery of a full-term baby. We did not notice any case of relapse of leukaemia in pregnancy.
Hołowiecka
Aleksandra
A
Katedra i Klinika Hematologii i Transplantacji Szpiku Slaskiej Akademii Medycznej w Katowicach.
Zielińska
Monika
M
Rozmus
Wioletta
W
Krzemień
Sławomira
S
Hołowiecki
Jerzy
J
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D011184:Postoperative Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D014182:Transplantation, Autologous