title: Synthesis and in vitro antitumor activity of platinum acetonimine complexes.
abstract: The cis- and trans-dichloro- and diiodo-platinum(II) complexes containing two acetonimines (cis- and trans-[PtX(2){HN=C(CH(3))(2)}(2)], 1 and 2 for X = Cl and 1' and 2' for X = I, respectively) or one acetonimine and one ammine (cis- and trans-[PtX(2)(NH(3)){HN=C(CH(3))(2)}], 3 and 4 for X = Cl and 3' and 4' for X = I, respectively) have been prepared from platinum-ammine precursors by condensation with acetone. Except for the cis-diiodo species, in all other cases the presence of a base was required. A crucial role of the ligand trans to the ammine undergoing condensation with acetone has been disclosed: the greater the trans effect the greater the reactivity. In a panel of human tumor cell lines representative of ovarian, colon, lung, and breast cancers, cis complexes 1 and 3 are less active than cis-DDP (mean IC(50) = 20, 12.5, and 2.8 microM, respectively), whereas trans complexes 2 and 4 are more active than trans-DDP (mean IC(50) = 10.6, 26, and 164 microM, respectively), thus indicating that substitution of acetonimine for one or two ammine ligands determines strikingly different effects depending upon the complex geometry.
authors.affiliation: Dipartimento di Scienze Biomediche ed Oncologia Umana, University of Bari, 70124 Bari, Italy.
authors.forename: Angelina
authors.initials: A
authors.lastname: Boccarelli
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Intini
authors.forename: Rossella
authors.initials: R
authors.lastname: Sasanelli
authors.forename: Maria F
authors.initials: MF
authors.lastname: Sivo
authors.forename: Mauro
authors.initials: M
authors.lastname: Coluccia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Natile
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008024:Ligands; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009944:Organoplatinum Compounds