title: Activation of cannabinoid CB1 receptors induces glucose intolerance in rats.
abstract: Recent reports have described the presence of cannabinoid CB1 receptors in pancreatic islets. Here we show that administration of the endogenous cannabinoid anandamide or the selective cannabinoid CB1 receptor agonist Arachidonyl-2'-chloroethylamide (ACEA) results in glucose intolerance after a glucose load. This effect is reversed by the selective cannabinoid CB1 receptor antagonist N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251). These results suggest that targeting cannabinoid CB1 receptors may serve as new therapeutic alternatives for metabolic disorders such as diabetes.
authors.affiliation: Fundación IMABIS, Hospital Carlos Haya, Avenida Carlos Haya s/n, 7(a) Planta, Pabellón A, Málaga 29010, Spain. franciscoj.bermudez.exts@juntadeandalucia.es
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Bermúdez-Siva
authors.forename: Antonia
authors.initials: A
authors.lastname: Serrano
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Diaz-Molina
authors.forename: Irene
authors.initials: I
authors.lastname: Sánchez Vera
authors.forename: Pablo
authors.initials: P
authors.lastname: Juan-Pico
authors.forename: Angel
authors.initials: A
authors.lastname: Nadal
authors.forename: Esther
authors.initials: E
authors.lastname: Fuentes
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez de Fonseca
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology; D063388:Endocannabinoids; D018149:Glucose Intolerance / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D001095:Arachidonic Acids; D001786:Blood Glucose; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; C119325:arachidonyl-2-chloroethylamide; C103505:AM 251; C078814:anandamide