title: Migrations in clinical and pathological stage of prostatic carcinoma in patients undergoing radical prostatectomy in the period between 1993 and 2003.
abstract: The aim of this study based on an analysis of personal material was to establish stage migration in a relatively large number of patients who had undergone radical retropubic ascendant prostatectomy (RRP). Between 01.07.1993. and 31.06.2003. RRP was performed in 801 patients at the urology department of the Kliniken-Essen-Mitte. Data regarding diagnostic workup, treatment and postoperative course were collected prospectively into a database. An analysis was made regarding clinical and pathological stage and numbers of patients with positive lymph nodes. During the observation period the number of radical prostatectomies increased significantly from 8 in 1993 to 130 in 2002. The number of organ-confined tumors increased continuously between 1997 and 2003. In contrast to this, advanced and metastatic tumors showed a continuous decrease from 76% in 1997 to 66% in 2002. Between 1994 and 2003 the number of T1c tumors increased by 20%. Introduction of systematic 12-cylinder biopsy (S12C) increased the detection of prostatic carcinoma by 38% and the number of diagnosed tumors of a lower clinical stage increased. These facts confirm a trend towards clinical and pathological stage migration resulting from extensive use of prostate specific antigen (PSA) and S12C biopsy in the diagnosis of prostatic carcinoma.
authors.affiliation: Clinic of Urology, Pediatric Urology and Urologic Oncology, Clinics of Essen-Mitte, Essen, Germany.
authors.forename: Nikola
authors.initials: N
authors.lastname: Zebić
authors.forename: Ulla
authors.initials: U
authors.lastname: Roggenbuck
authors.forename: Daniela
authors.initials: D
authors.lastname: Mandt
authors.forename: Darko
authors.initials: D
authors.lastname: Kröpfl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D042241:Early Diagnosis; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000706:statistics & numerical data* / Q000639:trends; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*; D018709:Statistics, Nonparametric
chemical_list: D017430:Prostate-Specific Antigen