title: Towards a multidisciplinary and integrated strategy in the assessment of adverse health effects related to air pollution: the case study of Cracow (Poland) and asthma.
abstract: Complex interaction between anthropogenic activities, air quality and human health in urban areas, such as in Cracow sustains the need for the development of an interdisciplinary and integrated risk-assessment methodology. In such purpose, we propose a pilot study performed on asthmatics and based on a combined use of a biomarker, such as metallothionein 2A (MT-2A) in the characterization of human exposure to one or a mixture of pollutants and of Geographical Information Systems (G.I.S.) which integrates climatic and urban anthropogenic parameters in the assessment of spatio-temporal dispersion of air pollutants. Considering global incidence of air pollution on asthma and on peripheral blood lymphocytes MT-2A expression should provide a complementary information on biological risks linked to urban anthropogenic activities. Such study would help for the establishment of a sustainable development in urban areas that can maintain the integrity of air quality and preserve human health.
authors.affiliation: Centre de Biogéographie-Ecologie FRE 2545 CNRS, Maison de la recherche, Université Paris-Sorbonne, Paris IV, 28 rue Serpente, 75006 Paris, France. biogeo@paris4.sorbonne.fr
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Oudinet
authors.forename: Julie
authors.initials: J
authors.lastname: Méline
authors.forename: Wojciech
authors.initials: W
authors.lastname: Chełmicki
authors.forename: Marek
authors.initials: M
authors.lastname: Sanak
authors.forename: Dutsch-Wicherek
authors.initials: DW
authors.lastname: Magdalena
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Besancenot
authors.forename: Stanislas
authors.initials: S
authors.lastname: Wicherek
authors.forename: Bertrand
authors.initials: B
authors.lastname: Julien-Laferrière
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Gilg
authors.forename: Hélène
authors.initials: H
authors.lastname: Geroyannis
authors.forename: Andrew
authors.initials: A
authors.lastname: Szczeklik
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Krzemień
mesh_terms: D000392:Air Movements; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002947:Cities; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D040362:Geographic Information Systems; D006801:Humans; D008668:Metallothionein / Q000097:blood; D011044:Poland; D018570:Risk Assessment / Q000379:methods; D014504:Urban Health
chemical_list: D015415:Biomarkers; C491053:MT2A protein, human; D008668:Metallothionein