title: Epidemiology data on 108 MEN 1 patients from the GTE with isolated nonfunctioning tumors of the pancreas.
abstract: OBJECTIVE
  To analyze the penetrance and clinical course of isolated nonfunctioning tumors of the pancreas (NFTP) in MEN 1 patients, and to propose a strategy for managing them.
  
  
  BACKGROUND
  Pancreaticoduodenal tumors develop in a majority of MEN 1 patients and are a major cause of death. The natural history of NFTP is poorly defined, and no clear-cut guidelines have been widely accepted regarding treatment.
  
  
  METHODS
  Data on 108 patients with isolated NFTP among 579 MEN 1 patients from the French Endocrine Tumor Study Group (GTE) were analyzed. Survival rates were calculated using the Kaplan-Meier method.
  
  
  RESULTS
  The penetrance of NFTP was 34% at age 50, making it the most frequent pancreaticoduodenal tumor in MEN 1 patients. Forty-three patients (40%) underwent surgery, 32 of them curatively. No patient died because of surgery. Average life expectancy for patients with NFTP was shorter than that for MEN 1 patients who did not have pancreaticoduodenal tumors. Thirteen patients died during follow-up, 10 due to NFTP. Tumor size was correlated with the risks of metastasis and death. These risks were low for patients with tumors<or=20 mm.
  
  
  CONCLUSIONS
  NFTP are currently the most common tumors of the pancreaticoduodenal region in patients with MEN 1. Prevention of tumor spread by surgery should be balanced with potential operative mortality and morbidity. We do not recommend routine surgery for NFTP<or=20 mm.
authors.affiliation: General and Endocrine Surgery, University Hospital, Lille, France. frederic.triponez@hcuge.ch
authors.forename: Frederic
authors.initials: F
authors.lastname: Triponez
authors.forename: David
authors.initials: D
authors.lastname: Dosseh
authors.forename: Pierre
authors.initials: P
authors.lastname: Goudet
authors.forename: Patrick
authors.initials: P
authors.lastname: Cougard
authors.forename: Catherine
authors.initials: C
authors.lastname: Bauters
authors.forename: Arnaud
authors.initials: A
authors.lastname: Murat
authors.forename: Guillaume
authors.initials: G
authors.lastname: Cadiot
authors.forename: Patricia
authors.initials: P
authors.lastname: Niccoli-Sire
authors.forename: Jean-Alain
authors.initials: JA
authors.lastname: Chayvialle
authors.forename: Alain
authors.initials: A
authors.lastname: Calender
authors.forename: Charles A G
authors.initials: CA
authors.lastname: Proye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000453:epidemiology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000601:surgery; D012042:Registries; D015996:Survival Rate