ILSMRs (intensifier of beta-lactam-susceptibility in methicillin-resistant Staphylococcus aureus) from Tara [Caesalpinia spinosa (Molina) Kuntze].
Four quinic acid gallates were isolated from the dried pods of Tara [Caesalpinia spinosa (Molina) Kuntze]. These compounds intensified the susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to oxacillin. 3,4,5-Tri-O-galloylquinic acid methyl ester (2) was the most effective compound of them.
Kondo
K
K
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Takaishi
Y
Y
Shibata
H
H
Higuti
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D029911:Caesalpinia / Q000737:chemistry*; D004357:Drug Synergism; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D010068:Oxacillin / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*; D047090:beta-Lactams / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D047090:beta-Lactams; D011801:Quinic Acid; D005707:Gallic Acid; D010068:Oxacillin