The fetal dermal but not loose fascial mesenchymal cells possess regenerative activity of dermal structure.
Fetal skin possesses a regenerative activity until certain developmental stages. However, the origin of cells that regenerate dermis after wounding has not been clarified yet. In the present study we located the origin of cells that reconstruct fetal dermal structure by histological examination and by marking cells in the loose fascia. Next we evaluated the regenerative activity of fetal dermal mesenchymal cells by cotransplanting with fetal epidermal cells onto the skin defect of scid mice. We conclude that fetal dermal mesenchymal cells but not loose fascial cells possess regenerative activity even on the environment in scid mice.
Kishi
Kazuo
K
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan. kkishi@sc.itc.keio.ac.jp
Katsube
Kenichi
K
Satoh
Hiroko
H
Imanishi
Nobuaki
N
Nakajima
Hideo
H
Nakajima
Tatsuo
T
D000818:Animals; D020405:Dermis / Q000166:cytology; D005260:Female; D005333:Fetus / Q000166:cytology; D008297:Male; D008648:Mesoderm / Q000166:cytology; D051379:Mice; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D012038:Regeneration / Q000502:physiology*; D012867:Skin / Q000166:cytology* / Q000648:ultrastructure; D016038:Skin Transplantation; D014945:Wound Healing / Q000502:physiology