title: Effect of previous argon laser trabeculoplasty on the ocular hypotensive action of latanoprost.
abstract: OBJECTIVE
  To study the effect of previous argon laser trabeculoplasty (ALT) on the hypotensive activity of latanoprost in primary open-angle glaucoma (POAG).
  
  
  METHODS
  This was a prospective, observer-masked study. We measured the intraocular pressure (IOP) before and after 3 months of monotherapy with latanoprost in 43 eyes that had undergone a previous ALT, and in a control group (not treated with ALT) of 43 IOP-matched eyes with POAG.
  
  
  RESULTS
  Latanoprost induced a 17.4+/-16.6% IOP decrease in the study group (ALT-treated eyes) and a 25.8+/-17.2% IOP reduction in the control eyes (P=0.02, unpaired Student's t-test).
  
  
  CONCLUSIONS
  Latanoprost is less effective in ALT-treated eyes than in eyes with POAG not treated with ALT.
authors.affiliation: Vissum Hospital Oftalmológico Madrid, Madrid, Spain. e.arranzmarquez@gmail.com
authors.forename: Esther
authors.initials: E
authors.lastname: Arranz-Marquez
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Teus
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D053685:Laser Therapy; D000077338:Latanoprost; D008297:Male; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D014130:Trabeculectomy
chemical_list: D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost