Diffuse large cell non-Hodgkin's lymphoma, CD30+, T-cell phenotype.
A 63-year-old Chinese man presented with an eczematous dermatitis that progressed into a multifocal nodular eruption. Histopathologic examination demonstrated a nodular and diffuse infiltrate in the reticular dermis, which was composed of lymphocytes, macrophages with granulomatous inflammation, and numerous eosinophils. Reactive lymphoid follicles with germinal centers also were present. Immunohistochemistry showed CD30 and LCA. ALK-1 and CD20 were negative. A diagnosis of CD30+ cutaneous T-cell lymphoma was made, and the patient is currently undergoing staging of his disease. Treatment options include excision of nodules, radiation therapy, and systemic chemotherapy.
Gruson
Lisa Moed
LM
Department of Dermatology, New York University School of Medicine, USA.
Latkowski
Jo-Ann
JA
D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*
D017730:Ki-1 Antigen