title: [Surgical therapy of infective endocarditis].
abstract: Therapy of infective endocarditis (IE) remains a particular challenge due to a relative high morbidity and mortality. Cardiac surgery is established as a cornerstone in therapy for native valve endocarditis (NVE) as well as for prosthetic valve endocarditis (PVE) and is required in 30% of patients with active IE. The basic aim of surgery in IE is the radical debridement of infected tissue and reconstruction of valve function either by reconstructive valve surgery or valve replacement. Indication for surgery depends on several clinical variables, the main indication remains heart failure due to severe heart valve defects or prosthetic valve dysfunction. Surgical therapy of NVE can be performed with good clinical results in the early and late follow-up. Surgical therapy of PVE is still associated with quite high mortality up to 80% in some risk groups. This indicates the particular importance of focus evaluation and antibiotic prophylaxis after primary surgery for infective endocarditis.
authors.affiliation: Herzzentrum Dresden, Universitätsklinik, Klinik für Kardiochirurgie, Fetscherstrasse 76, 01307 Dresden. c.lehmann@herzzentrum-dresden.com
authors.forename: S M
authors.initials: SM
authors.lastname: Tugtekin
mesh_terms: D019072:Antibiotic Prophylaxis; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000601:surgery*; D005500:Follow-Up Studies; D006333:Heart Failure / Q000601:surgery; D006349:Heart Valve Diseases / Q000175:diagnosis / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000601:surgery; D012086:Reoperation