Cyclodextrin-based isolation of Ostwald's metastable polymorphs occurring during crystallization.
We describe a novel approach for the selective isolation of Ostwald's intermediate metastable polymorphs occurring during an early stage of crystallization, by utilizing the inclusion complex formed with a cyclic oligosaccharide derivative, 2,6-di-O-methyl-beta-cyclodextrin.
Sonoda
Yoh
Y
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. uekama@gpo.kumamoto-u.ac.jp
Hirayama
Fumitoshi
F
Arima
Hidetoshi
H
Yamaguchi
Yoshihiro
Y
Saenger
Wolfram
W
Uekama
Kaneto
K
D003460:Crystallization; D003505:Cyclodextrins / Q000737:chemistry*; D015394:Molecular Structure; D013997:Time Factors; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry
D003505:Cyclodextrins; D047392:beta-Cyclodextrins