Comparison of unilateral and bilateral transfer of injected oocytes into fallopian tubes: a prospective, randomized clinical trial.
OBJECTIVE
To assess whether pregnancy rate differs in unilateral vs. bilateral transfer in "immediate transfer of injected oocytes into the fallopian tubes."


METHODS
Prospective randomized clinical trial.


METHODS
Tertiary university hospital.


METHODS
The study population included 160 patients presenting with male factor infertility who fulfilled the criteria for immediate transfer of injected oocytes into tubes.


METHODS
Four injected oocytes were transferred into two tubes (study group) or one tube (control group).


METHODS
Implantation rate, clinical pregnancy rate, multiple pregnancy rate, and incidence of pregnancy with unknown location (PUL).


RESULTS
A total of 72 (45%) pregnancies were achieved. There were 32 pregnancies (1 PUL, 4 multiple, and 27 singletons) in the bilateral transfer group and 40 pregnancies in the unilateral transfer group (1 PUL, 7 multiple, and 32 singletons). No significant difference was found in the implantation rate, clinical pregnancy rate, multiple pregnancy rate, and incidence of PUL.


CONCLUSIONS
This study demonstrates that no difference in outcome occurred between unilateral and bilateral transfer in microinjected oocytes intrafallopian transfer (MIFT). Therefore, along with the same outcome parameters, unilateral transfer is the preferred method of MIFT.
Alleyassin
Ashraf
A
Dr. Shariati Hospital, Department of Obstetrics and Gynecology, Vali-e-asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Khademi
Afsaneh
A
Aghahosseini
Marzieh
M
Safdarian
Leili
L
Saeidabadi
Hojatollah Saeidi
HS
Hedayati
Hylda
H
D000293:Adolescent; D000328:Adult; D005187:Fallopian Tubes; D005260:Female; D015181:Gamete Intrafallopian Transfer / Q000379:methods*; D006801:Humans; D008845:Microinjections; D009865:Oocytes / Q000166:cytology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple / Q000706:statistics & numerical data; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic