title: Small molecule inhibitors of plasma kallikrein.
abstract: Plasma kallikrein is a serine protease that is involved in pathways of inflammation, complement fixation, coagulation, and fibrinolysis. Herein, we describe the SAR and structural binding modes of a series of inhibitors of plasma kallikrein as well as the pharmacokinetics of a lead analog 11 in rat.
authors.affiliation: Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. wendy.young@yahoo.com
authors.forename: Wendy B
authors.initials: WB
authors.lastname: Young
authors.forename: Roopa
authors.initials: R
authors.lastname: Rai
authors.forename: William D
authors.initials: WD
authors.lastname: Shrader
authors.forename: Jana
authors.initials: J
authors.lastname: Burgess-Henry
authors.forename: Huiyong
authors.initials: H
authors.lastname: Hu
authors.forename: Kyle C
authors.initials: KC
authors.lastname: Elrod
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sprengeler
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Katz
authors.forename: Juthamas
authors.initials: J
authors.lastname: Sukbuntherng
authors.forename: Joyce
authors.initials: J
authors.lastname: Mordenti
mesh_terms: D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000097:blood; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D015842:Serine Proteinase Inhibitors; D007610:Kallikreins