Eczema-like plaques secondary to enoxaparin.
Low-molecular-weight heparins are used extensively in acute medicine. They are generally well tolerated but may cause a rare, eczema-like type IV hypersensitivity reaction. We report 3 cases of this eruption and speculate that it may be significantly under-reported due to misidentifying the causal drug, which may have serious consequences. We discuss treatment alternatives such as fondaparinux sodium, which may rarely cross-react.
White
J M L
JM
Department of Dermatology, Orpington Hospital, Sevenoaks Road, Orpington, Kent BR6 9JU, UK. onathanmlwhite@hotmail.com
Munn
S E
SE
Seet
J-E
JE
Adams
N
N
Clement
M
M
D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004485:Eczema / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D017984:Enoxaparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D020246:Venous Thrombosis / Q000188:drug therapy; D014946:Wound Infection / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D017984:Enoxaparin; D019980:Amoxicillin-Potassium Clavulanate Combination