Antialgal, antibacterial and antifungal activity of two metabolites produced and excreted by cyanobacteria during growth.
The antimicrobial activity of two cyanobacterial exometabolites, norharmane (9H-pyrido(3,4-b)indole) and 4,4'-dihydroxybiphenyl, was determined in suspension assays. Good anticyanobacterial activities (concentrations of 8-80 microg ml(-1)) and moderate antibacterial (16-160 microg ml(-1)) and antifungal (32-40 microg ml(-1)) activities were found for both compounds. The natural function as allelopathic chemicals and a possible applicability as antifouling agents or leads for the development of new antifouling chemicals are discussed.
Volk
Rainer-B
RB
Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Kiel, Gutenbergstrasse 76, Kiel, D-24118, Germany. volk@pharmazie.uni-kiel.de
Furkert
Franz H
FH
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism / Q000494:pharmacology*; D002243:Carbolines; D000458:Cyanobacteria / Q000254:growth & development / Q000378:metabolism*; D006247:Harmine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001713:Biphenyl Compounds; D002243:Carbolines; D006247:Harmine; C010262:norharman; C027439:4,4'-dihydroxybiphenyl