Neurochemical estimations of some new quaternary phenacyl-bromopiperidinium compounds.
Considering the fact that N-alkyl substituted quaternary ammonium salts of piperidinium bromide induce brain catecholamine and indoleamine metabolism (Black et al., 1986), we thought it may be valuable to investigate the effects of three selected phenacyl derivatives (I, V and VIII) of piperidine on brain monoamines metabolism in mice (100mg/kg body weight) assuming that these derivatives might alter the brain indoleamine and catecholamine levels differently. Studies are carried out by using HPLC technique. It was found that compound VIII possessed greater neuroleptic activity as compared to compounds I and V.
Akhtar
Shamim
S
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Saify
Zafar Saied
ZS
Arif
Muhammad
M
Mushtaq
Nousheen
N
Haleem
Darakhshan J
DJ
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists / Q000737:chemistry / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism
D018492:Dopamine Antagonists; D010880:Piperidines; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid