[Local cytokine levels and morphological parameters in chronic viral hepatitis C].
The association of the level of local cytokines, such as interleukin (IL)-1alpha, IL-2, IL-4, tumor necrosis factor-alpha (TNF-alpha), and gamma-interferon (gamma-INF) was studied in the liver biopsy specimens from patients with chronic hepatitis C (CHC) with clinical and morphological indices and biochemical and virological findings. There was a polymorphism of clinical symptoms, as well as extrahepatic manifestations in the group that had significantly elevated levels of IL-1alpha, IL-4, and TNF-alpha, as well as decreased concentrations of IL-2 and gamma-INF. The activity of necrotic inflammatory manifestations in the liver in CHC is also associated with a more pronounced shift towards an increase in the levels of IL-1alpha, IL-4, and TNF-alpha, and a decrease in those of IL-2 and gamma-INF.
Skliar
L F
LF
Markelova
E V
EV
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D019698:Hepatitis C, Chronic / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007371:Interferon-gamma / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007371:Interferon-gamma