title: Prediction of MEF2A-DNA interface by rigid body docking: a tool for fast estimation of protein mutational effects on DNA binding.
abstract: The protein-protein docking algorithm ZDOCK has been challenged for the first time to predict protein-DNA contacts. The computational approach defined in this study has proven effectiveness in fast in silico estimations of mutational effects of the MEF2A transcription factor on DNA binding.
authors.affiliation: Department of Chemistry, University of Modena and Reggio Emilia, Via Campi 183, Modena, Italy. fanelli@unimo.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Fanelli
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrari
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D026161:MADS Domain Proteins / Q000737:chemistry* / Q000235:genetics; D064326:MEF2 Transcription Factors; D008958:Models, Molecular; D009154:Mutation; D018006:Myogenic Regulatory Factors / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation; D012984:Software
chemical_list: D004268:DNA-Binding Proteins; D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; C578035:MEF2A protein, human; D018006:Myogenic Regulatory Factors; D004247:DNA