Improvement in dermatomyositis rash associated with the use of antiestrogen medication.
BACKGROUND
Dermatomyositis (DM) is an autoimmune disorder that occurs more often in women than men and causes highly symptomatic and inflammatory cutaneous and proximal muscle disease. Corticosteroids have been the treatment of choice for myositis in DM, and antimalarial agents for the skin disease of DM, with methotrexate sodium, azathioprine, mycophenolate mofetil, cyclosporine, and intravenous immunoglobulin used as steroid-sparing agents. Recently, reports supporting a role for anti-tumor necrosis factor alpha (TNF-alpha) therapy in the treatment of DM have emerged.


METHODS
We describe 2 women who experienced an improvement in their DM-associated skin eruptions while taking antiestrogen medication. The first patient was taking tamoxifen, a selective estrogen receptor modulator that has been found to have anti-TNF-alpha properties. The second was taking anastrozole, an aromatase inhibitor. When tamoxifen therapy was discontinued after 4 years of use in the first patient, her DM rash worsened and remained difficult to control with conventional immunosuppressant medication.


CONCLUSIONS
With the limited number of therapies available to manage DM skin eruptions, the discovery of novel agents effective in treating this disease is vital. Using antiestrogen medication in women with DM may result in a significant improvement in their rash, possibly via the inhibition of TNF-alpha production by immune or other cells. Further investigation into the use of antiestrogen therapy in DM is merited to evaluate long-term risks and benefits.
Sereda
Danya
D
Section of Dermatology, Université de Montréal.
Werth
Victoria P
VP
D000328:Adult; D000077384:Anastrozole; D001706:Biopsy; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy; D003882:Dermatomyositis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003937:Diagnosis, Differential; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005076:Exanthema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009570:Nitriles / Q000009:adverse effects; D012867:Skin / Q000473:pathology; D013629:Tamoxifen / Q000009:adverse effects; D014230:Triazoles / Q000009:adverse effects
D004965:Estrogen Antagonists; D005938:Glucocorticoids; D009570:Nitriles; D014230:Triazoles; D013629:Tamoxifen; D000077384:Anastrozole