title: Genetics of deafness: recent advances and clinical implications.
abstract: Genetic research into the causes of deafness has advanced considerably in the last years. Progress has been made in both discovering loci and cloning genes associated with syndromic and non-syndromic hearing loss. To date, close to 75 loci have been identified and 29 genes have been cloned for non-syndromic deafness. The proteins these genes encode range from transcription factors to molecular motors to ion channels. We review the recent discoveries and discuss the impact of this research.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Goldfarb
authors.forename: Karen B
authors.initials: KB
authors.lastname: Avraham
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D003638:Deafness / Q000235:genetics* / Q000628:therapy*; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D014960:X Chromosome
chemical_list: D004272:DNA, Mitochondrial