Paraoxonase 1 gene polymorphisms influence clinical features of open-angle glaucoma.
BACKGROUND
The purpose of this study was to determine whether genetic polymorphisms affecting high-density lipoprotein (HDL)-associated antioxidant enzymes were associated with open-angle glaucoma (OAG). The rationale for this study was that the modification of low-density lipoprotein (LDL) by HDL prevents oxidative modification which can then cause dysfunction of endothelial cells.


METHODS
We studied 284 normal Japanese controls and 555 Japanese patients with OAG, including primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). The possible associations of polymorphisms of PON1/L55M, PON1/Q192R, PON2/S311C, and PAF-AH/V279F with OAG were investigated. We compared the genotype distributions and allele frequency in controls and patient groups. The age at diagnosis, intraocular pressure (IOP) at diagnosis, and visual field score at diagnosis were examined for association with polymorphisms.


RESULTS
The distributions of genotypes and allele frequency for the four polymorphisms were not significantly different between any patient group and controls. In NTG patients, 55M carriers of the PON1 gene were significantly older at diagnosis than 55M non-carriers (P=0.001). The IOP at diagnosis was significantly higher in glaucoma patients carrying 192R in the PON1 gene than in patients not carrying 192R (P=0.006). No significant differences were seen in clinical characteristics of OAG patients in relation to other polymorphisms.


CONCLUSIONS
PON1 gene polymorphisms may influence the features of Japanese patients with OAG.
Inagaki
Yoko
Y
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Mashima
Yukihiko
Y
Funayama
Tomoyo
T
Ohtake
Yuichiro
Y
Fuse
Nobuo
N
Yasuda
Noriko
N
Fukuchi
Takeo
T
Murakami
Akira
A
Hotta
Yoshihiro
Y
D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human