title: The yield of subtelomeric FISH analysis in the evaluation of autistic spectrum disorders.
abstract: To assess the frequency of cryptic subtelomeric rearrangements in children and adolescents with autism spectrum disorders, blood samples were studied using a complete set of subtelomeric FISH probes in 72 children with autism spectrum disorders. All children had normal high resolution karyotype, DNA fra-X analysis, brain MRI, metabolic work-up, and physical/neurological examination. Subtelomeric analysis did not detect abnormalities in any of the subjects, suggesting the uselessness of such investigations in individuals with primary autism spectrum disorders.
authors.affiliation: University of Pisa, and Stella Maris Clinical Research Institute for Child and Adolescent Neuropsychiatry, via dei Giacinti 2, 56018 Calambrone, Pisa, Italy. abattaglia@inpe.unipi.it
authors.forename: Agatino
authors.initials: A
authors.lastname: Battaglia
authors.forename: Maria C
authors.initials: MC
authors.lastname: Bonaglia
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000235:genetics; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D016615:Telomere / Q000235:genetics*