title: Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: a 3-year follow-up study.
abstract: OBJECTIVE
  To investigate the effect of H pylori eradication on atrophic gastritis and intestinal metaplasia (IM).
  
  
  METHODS
  Two hundred and fifty-nine patients with atrophic gastritis in the antrum were included in the study, 154 patients were selected for H pylori eradication therapy and the remaining 105 patients served as untreated group. Gastroscopy and biopsies were performed both at the beginning and at the end of a 3-year follow-up study. Gastritis was graded according to the updated Sydney system.
  
  
  RESULTS
  One hundred and seventy-nine patients completed the follow-up, 92 of them received H pylori eradication therapy and the remaining 87 H pylori-infected patients were in the untreated group. Chronic gastritis, active gastritis and the grade of atrophy significantly decreased in H pylori eradication group (P<0.01). However, the grade of IM increased in H pylori -infected group (P<0.05).
  
  
  CONCLUSIONS
  H pylori eradication may improve gastric mucosal inflammation, atrophy and prevent the progression of IM.
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Zhejiang Traditional Chinese Medicine College, Hangzhou 310006, Zhejiang Province China. lvbin@medmail.com.cn
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
authors.forename: Ming-Tao
authors.initials: MT
authors.lastname: Chen
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Fan
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Meng
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005757:Gastritis, Atrophic / Q000382:microbiology* / Q000473:pathology* / Q000517:prevention & control; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011230:Precancerous Conditions / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents