Bioavailability and disposition kinetics of rifampicin capsules.
Different drug manufactures claim better quality and bioavailability of the similar dosage from of a drug product. In view of this, bioequivalence on the basis of bioavailability and disposition kinetics of rifampicin capsules marketed under the brand names of Rifadin, Rifapin and Rimactane were investigated in normal human volunteers. Each drug was given orally and blood levels of active rifampicin at different times were measured by a microbiological assay procedure. The studies revealed that the absorption kinetics, bioavailability and disposition kinetics of three brands of rifampicin did not differ from each other significantly in human volunteers.
Nawaz
M
M
Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.