title: Bleeding prophylaxis in a child with cleft palate and factor VII deficiency: a case report.
abstract: The association between factor VII deficiency and cleft palate has never been described. The case of a child with cleft palate and factor VII deficiency who successfully underwent palatoplasty is described in this article. To allow surgical treatment, through maintenance of a normal prothrombin time, the patient was given 15 microg/kg of recombinant factor VIIa every 12 hours, starting 20 minutes before surgery and ending the third postoperative day. No abnormal perioperative bleeding was observed. Use of recombinant factor VIIa in bleeding prophylaxis or treatment is widespread. Doses are much higher in these cases. The reduction of dosage allows easier administration, especially in pediatric patients, without affecting drug efficacy.
authors.affiliation: Dipartimento di Discipline Chirurgiche ed Oncologiche, Sezione di Chirurgia Plastica e Ricostruttiva, Università di Palermo, Palermo, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pirrello
authors.forename: Sergio
authors.initials: S
authors.lastname: Siragusa
authors.forename: Cristiano
authors.initials: C
authors.lastname: Giambona
authors.forename: Salvatore
authors.initials: S
authors.lastname: D'Arpa
authors.forename: Adriana
authors.initials: A
authors.lastname: Cordova
authors.forename: Francesco
authors.initials: F
authors.lastname: Moschella
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002675:Child, Preschool; D002972:Cleft Palate / Q000601:surgery*; D003029:Coagulants / Q000008:administration & dosage / Q000627:therapeutic use; D005168:Factor VII Deficiency / Q000517:prevention & control*; D015942:Factor VIIa / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010159:Palate / Q000601:surgery; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D011292:Premedication; D011517:Prothrombin Time; D011994:Recombinant Proteins; D019651:Plastic Surgery Procedures
chemical_list: D003029:Coagulants; D011994:Recombinant Proteins; D015942:Factor VIIa