title: Protein sensors for membrane sterols.
abstract: Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. joe.goldstein@utsouthwestern.edu
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Goldstein
authors.forename: Russell A
authors.initials: RA
authors.lastname: DeBose-Boyd
authors.forename: Michael S
authors.initials: MS
authors.lastname: Brown
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D008954:Models, Biological; D013261:Sterols / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D013261:Sterols