The effect of centrally acting drug chlorpromazine on the secretion of prolactin in the lizard, Uromastix hardwickii.
This investigation deals with the effect of chlorpromazine, on Uromastix hypophyseal prolactin. Administration of the doses 0.125, 0.25, 0.5 and 1 mg chlorpromazine per 3 days per animal resulted in a significant increase pigeon crop-sac response (p<0.01). The degree of proliferation of crop-gland showed a dose dependent threshold. Chlorpromazine binds to the target cell specific receptors of PRL and GH, both at the same time.
Ahmad
Mahmood
M
Department of Physiology, University of Karachi, Karachi-75270, Pakistan.
Hasan
Ruqaiya
R
Yameen
Sohail
S
Ahmad
Mansoor
M