title: [Lifestyle intervention in the treatment of severe obesity].
abstract: BACKGROUND
  The prevalence of overweight and obesity is escalating globally, and in Denmark more than 10% of the population are now severely overweight. The aim of this study was to estimate the short-term health effects of 15 weeks of intensive lifestyle intervention composed of physical activity, dietary changes and personal development in severely obese subjects of both sexes.
  
  
  METHODS
  The 27 subjects were weighed weekly. Fat percentage, abdominal circumference, maximum oxygen uptake, heart rate, oral glucose tolerance and blood lipids were measured at baseline and in week 15. The intensive lifestyle intervention was completed under supervision at a stay at Ebeltoft Kurcenter, and the goal was a weight loss of approximately 1% per week.
  
  
  RESULTS
  At baseline, the participants' average body mass index (BMI: kg/m2) was 44 +- 1; the BMI was reduced by 11% after the stay (p<0.001). Body weight was reduced by 14 +- 4 kg (p<0.001), corresponding to 76% of the desired weight loss. The subjects' fat mass was reduced by 4% (p<0.001), and their maximal oxygen uptake was enhanced by 25% (p<0.001). Concerning the blood lipids, total cholesterol was reduced by 8% (p = 0.03); there was no significant change in LDL level and a reduction of 15% (p<0.05) in HDL level. After the intervention, oral glucose tolerance was significantly improved (p<0.001).
  
  
  CONCLUSIONS
  After 15 weeks of intensive lifestyle intervention, there were significant improvements in aerobic fitness and metabolic risk parameters, and the observed weight loss was equivalent to that obtained by surgical treatment. Decisive in the choice of obesity treatment will continue to be the extent of success in permanent weight loss.
authors.affiliation: Københavns Universitet, Medicinsk Fysiologisk Institut, Center for Muskelforskning, Arhus Universitetshospital, Medicinsk Endokrinologisk Afdeling C, København N.
authors.forename: Jane Østergaard
authors.initials: JØ
authors.lastname: Pedersen
authors.forename: Esther
authors.initials: E
authors.lastname: Zimmermann
authors.forename: Bente Merete
authors.initials: BM
authors.lastname: Stallknecht
authors.forename: Jens Meldgaard
authors.initials: JM
authors.lastname: Bruun
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Kroustrup
authors.forename: Jens Fromholt
authors.initials: JF
authors.lastname: Larsen
authors.forename: Jørn Wulff
authors.initials: JW
authors.lastname: Helge
mesh_terms: D050153:Abdominal Fat / Q000033:anatomy & histology; D015992:Body Mass Index; D015444:Exercise; D005247:Feeding Behavior; D005260:Female; D005951:Glucose Tolerance Test; D006439:Hemodynamics; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000175:diagnosis / Q000178:diet therapy / Q000523:psychology / Q000628:therapy*; D012649:Self Concept; D013997:Time Factors; D015431:Weight Loss
chemical_list: D008055:Lipids