title: Membranous obstruction of the inferior vena cava and its causal relation to hepatocellular carcinoma.
abstract: Although rare in most countries, membranous obstruction of the inferior vena cava (MOIVC) occurs more frequently in Nepal, South Africa, Japan, India, China, and Korea. The occlusive lesion always occurs at approximately the level of the diaphragm. It commonly takes the form of a membrane, but may be a fibrotic occlusion of variable length. Controversy exists as to whether MOIVC is a developmental abnormality or a result of organization of a thrombus in the hepatic portion of the inferior vena cava. The outstanding physical sign associated with MOIVC are large truncal collateral vessels with a cephalad flow. A dilated vena azygous is seen on chest radiography. Definitive diagnosis is made by contrast inferior vena cavography. The long-standing obstruction to hepatic venous flow causes severe centrolobular fibrosis and predisposes to the development of hepatocellular carcinoma (HCC). Percutaneous balloon angioplasty, transatrial membranotomy, or more complex vena caval and portal decompression surgery should be performed to prevent these complications. HCC occurs in more than 40% of South African Black and Japanese patients with MOIVC, but less often in other populations. It is thought to result from the tumour-promoting effect of continuous hepatocyte necrosis, although the associated environmental risk factors have not been identified.
authors.affiliation: MRC/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, and Johannesburg and Baragwanath Hospitals, Johannesburg, South Africa. kewmc@medicine.wits.ac.za
authors.forename: M C
authors.initials: MC
authors.lastname: Kew
authors.forename: H J
authors.initials: HJ
authors.lastname: Hodkinson
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods; D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000208:ethnology; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D013019:South Africa / Q000453:epidemiology; D015607:Stents; D015996:Survival Rate; D015912:Thrombolytic Therapy / Q000379:methods; D014682:Vena Cava, Inferior / Q000002:abnormalities*; D020246:Venous Thrombosis / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy