title: Survival in France after childhood acute leukaemia and non-Hodgkin's lymphoma (1990-2000).
abstract: This article describes the survival after childhood acute leukaemia (AL) and non-Hodgkin's lymphoma (NHL) of French population aged less than 15 years. The French National Registry of Childhood Leukaemia and Lymphoma recorded 3995 cases of acute lymphoblastic leukaemia (ALL), 812 of acute myeloid leukaemia (AML) and 1137 of NHL over the period from 1990 to 2000. Overall survival rates at 5 years were 82% (95% CI 80-83), 58% (95% CI 54-61) and 87% (95% CI 85-89) for ALL, AML and NHL, respectively. Survival after AL increased from 77% (95% CI 75-80) in 1990-1992 to 85% (95% CI 83-87) in 1997-2000 for ALL and from 47% (95% CI 41-54) to 61% (95% CI 55-67) for AML. Among AL cases, children aged 1-4 years had the most favourable prognosis. Down's syndrome was associated with poor survival after ALL. No gender-related variations in survival were in evidence. The results reported herein are similar to those reported by other European registries and clinical trials.
authors.affiliation: INSERM, U754, Villejuif, France. goubin@vjf.inserm.fr
authors.forename: A
authors.initials: A
authors.lastname: Goubin
authors.forename: M F
authors.initials: MF
authors.lastname: Auclerc
authors.forename: A
authors.initials: A
authors.lastname: Auvrignon
authors.forename: C
authors.initials: C
authors.lastname: Patte
authors.forename: C
authors.initials: C
authors.lastname: Bergeron
authors.forename: D
authors.initials: D
authors.lastname: Hémon
authors.forename: J
authors.initials: J
authors.lastname: Clavel
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004314:Down Syndrome / Q000401:mortality; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000401:mortality*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents