Inhibition of pemphigus vulgaris by targeting of the CD40-CD154 co-stimulatory pathway: a step toward antigen-specific therapy?
The signaling of CD40 by its ligand, CD154, between T and B cells is required for humoral immune responses. Thus, blockade of this ligand-receptor interaction can prevent the development of antibody-mediated autoimmune diseases through different mechanisms.
Liu
Zhi
Z
Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. zhiliu@med.unc.edu
Li
Ning
N
Diaz
Luis A
LA
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology*; D006801:Humans; D010392:Pemphigus / Q000188:drug therapy* / Q000276:immunology
D000906:Antibodies; D019013:CD40 Antigens; D023201:CD40 Ligand