title: The effect of gynecologic laparoscopy on propofol concentrations administered by the target-controlled infusion system.
abstract: The purpose of this study was to assess the effect of gynecologic laparoscopy on propofol concentrations administered by the target-controlled infusion (TCI) system. Thirteen patients undergoing gynecologic laparoscopy (intraabdominal pressure of 10 mmHg) were enrolled in this study. Anesthesia was induced with vecuronium 0.1 mg.kg(-1) and propofol, then maintained by 60% nitrous oxide and sevoflurane in oxygen and a constant infusion of propofol. Propofol was administered to all subjects by means of a target-controlled infusion to achieve propofol plasma concentration at 6.0 microg.ml(-1) at intubation and 2.0 microg.ml(-1) after intubation. Before and during laparoscopy, plasma propofol concentration was determined using high-performance liquid chromatograhy. Cardiac output (CO) and effective liver blood flow (LBF) were also measured using indocyanine green as an indicator. Before and during pneumoperitoneum, there were no significant differences in propofol concentrations between each point. Propofol concentrations were well achieved to predicted concentrations administered by the TCI system during gynecologic laparoscopy under propofol and sevoflurane anesthesia.
authors.affiliation: Department of Anesthesiology, Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi 371-8511, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takizawa
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Hiraoka
authors.forename: Eri
authors.initials: E
authors.lastname: Sato
authors.forename: Toshio
authors.initials: T
authors.lastname: Aso
authors.forename: Chizu
authors.initials: C
authors.lastname: Aso
authors.forename: Fumio
authors.initials: F
authors.lastname: Kunimoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Goto
mesh_terms: D000328:Adult; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008102:Liver Circulation / Q000187:drug effects; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D015742:Propofol