title: Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.
abstract: An intermediate molecular weight contrast agent P760 was used to investigate the ability of multi-slice dynamic contrast-enhanced MRI (DCE-MRI) to distinguish metastatic from non-metastatic rodent prostate tumors. Non-metastatic AT2.1 and metastatic AT3.1 prostate tumors originally derived from the Dunning prostate cancer model were implanted on the hind leg of Copenhagen rats. Multi-sliced DCE-MRI data were acquired on a SIGNA 1.5 T scanner and analyzed using a recently developed empirical mathematical model. The P760 multi-slice DCE-MRI data in combination with the empirical mathematical model successfully distinguished between metastatic and non-metastatic rodent prostate tumors. Specifically, fitting the data with the empirical model showed that metastatic tumors had significantly faster contrast media uptake (p<0.001) and slower washout rates (p<0.01) than non-metastatic tumors.
authors.affiliation: Department of Radiology, University of Chicago, IL 60637, USA. xfan@uchicago.edu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fan
authors.forename: Milica
authors.initials: M
authors.lastname: Medved
authors.forename: Sean
authors.initials: S
authors.lastname: Foxley
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: River
authors.forename: Marta
authors.initials: M
authors.lastname: Zamora
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Karczmar
authors.forename: Claire
authors.initials: C
authors.lastname: Corot
authors.forename: Philippe
authors.initials: P
authors.lastname: Robert
authors.forename: Philippe
authors.initials: P
authors.lastname: Bourrinet
mesh_terms: D000465:Algorithms; D019412:Anatomy, Cross-Sectional / Q000379:methods*; D000818:Animals; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D011471:Prostatic Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000556:secondary*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D009942:Organometallic Compounds; C120577:gadolinium compound P760