title: Genome-based phylogeny of poxvirus.
abstract: A comprehensive phylogenetic analysis of Poxviridae was performed in this study. Phylogenetic trees were reconstructed from whole genomic information including gene order, gene content, and all conserved gene protein sequences. Gene content and gene order were the methods used for the first time in cladogram reconstruction of poxvirus. The results of the different methods finally shared mainly consistent tree topologies, which were supported by the classic taxonomy of Poxviridae. According to these topologies, the Entomopoxvirinae and Chordopoxvirinae subfamilies are divergent from each other. Subfamily Chordopoxvirinae could be divided into four main groupings, which could be further divided into subgroups. Parapoxvirus and Molluscipoxvirus have been considered distinct from other Chordopoxvirus. Results from our study consistently supported this suggestion. In our results, Parapoxvirus and Molluscipoxvirus were the most closely related genera and formed a group. This group could be the one that branched after the divergence of Avipoxviruses. Additionally, rabbitpox virus and vaccinia virus steadily formed clusters with high bootstrap support in all the cladograms.
authors.affiliation: State Key Laboratory for Biocontrol, School of Life Science, Sun Yat-Sen (Zhongshan) University, Guangzhou, PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xing
authors.forename: Riqiang
authors.initials: R
authors.lastname: Deng
authors.forename: Jinwen
authors.initials: J
authors.lastname: Wang
authors.forename: Jinghua
authors.initials: J
authors.lastname: Feng
authors.forename: Mingsong
authors.initials: M
authors.lastname: Huang
authors.forename: Xunzhang
authors.initials: X
authors.lastname: Wang
mesh_terms: D001483:Base Sequence; D017124:Conserved Sequence; D023061:Gene Order; D016679:Genome, Viral; D005810:Multigene Family; D010802:Phylogeny; D011212:Poxviridae / Q000145:classification* / Q000235:genetics*; D017422:Sequence Analysis, DNA