[Wheat anaphylaxis enhanced by administration of acetylsalicylic acid or by exercise].
A 23-year-old woman experienced generalized urticaria and loss of consciousness during walking after ingestion of wheat. Skin prick test and CAP-RAST were positive for gluten. An oral challenge test using 100g wheat was positive without exercise. The patient was given diagnosis of wheat allergy. In addition, not only exercise but also administration of 500mg aspirin were found to exacerbate her symptoms after the ingestion of wheat, suggesting that acetylsalicylic acid could be an augmentation factor in wheat allergy. Etodorac failed to enhance the symptoms. Further, oral administration of Fexofenadine could prevent allergic reactions induced by ingestion of 100g wheat, but sodium cromoglycate partially reduced the reactions.
Fujita
Hiroyuki
H
Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. fuji_fuji_fuji_0101@yahoo.co.jp
Osuna
Hiroyuki
H
Kanbara
Takeshi
T
Inomata
Naoko
N
Ikezawa
Zenro
Z
D000284:Administration, Oral; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D004205:Cromolyn Sodium / Q000008:administration & dosage; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D011852:Radioallergosorbent Test; D012882:Skin Tests; D016593:Terfenadine / Q000008:administration & dosage / Q000031:analogs & derivatives; D021182:Wheat Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control
D016593:Terfenadine; C093230:fexofenadine; D004205:Cromolyn Sodium; D001241:Aspirin