Pronounced inhibitory effect of chlorcyclizine (CCZ) in experimental hepatocarcinoma.
Thepiperazine chlorcyclizine HCl (CCZ), possessing significant antimetabolic as well as virucidal and virustatic activities against the human immunodeficiency virus (HIV) and other retroviruses, was selected to determine its anticarcinogenic potential The anticancer activity of CCZ was evaluated against procarcinogen n-diethylnitrosamine (NDA)-initiated hepatocarcinogenesis, which was subsequently promoted by phenobarbital (PB) in male Sprague-Dawley rats. The anticancer efficacy of CCZ was monitored by estimating some potential markers of neoplastic and preneoplastic hepatic conditions, e.g., glutathione (GSH), glutathione-S-transferase (GST) and gamma-glutamyl transpeptidase (gammaGTP). CCZ exhibited antineoplastic activity on a long-term therapeutic basis. Furthermore, this drug restricted the exponential increase of the antioxidant markers in the hyperplastic nodule and the surrounding liver tissues in comparison with the carcinogen-controlled rats during the entire period of treatment. A decrease in the number of nodules was observed in the CCZ-treated group.
Dastidar
Sujata G
SG
Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.
Ganguly
Kumkum
K
Mahapatra
S K
SK
Dutta
Noton Kumar
NK
Mazumdar
Kaushiki
K
Chakrabarty
A N
AN
Motohashi
Noboru
N
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004052:Diethylnitrosamine / Q000633:toxicity; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010634:Phenobarbital / Q000633:toxicity; D010879:Piperazines / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D010879:Piperazines; D004052:Diethylnitrosamine; C084597:chlorcyclizine; D010634:Phenobarbital