title: Efficacy of prophylaxis in women with sex induced cystitis.
abstract: Sexual intercourse has been established as one of the most important risk factors for both isolated and recurrent uncomplicated infections of the urinary tract. Prophylactic therapy requires only a small dose of an antimicrobial agent, which is generally given at bedtime for 6 to 12 months. An alternative method is to give an antimicrobial agent for six months post-intercourse. It is still unknown which of the two methods is most effective. A total of 123 women with suspected sexually induced recurrent cystitis (mean age 28 years, range 15 to 65) and a history of recurrent urinary tract infection (UTI) (the last one within the last six months) were subjected to prophylactic therapy for six months. Half of them were treated with low-dose trimethoprim-cotrimoxazole (TMP-SMX) and cefaclor given orally post-intercourse (spontaneous usage), while the other half were treated with low-dose TMP-SMX and cefaclor given at bedtime. The response to the prophylactic therapy was classified as continued cure in 106 cases (86.17%), failure in 13 cases (10.56%), and unknown in four cases (3.25%). TMP-SMX administered in continuous nightly prophylaxis showed similar efficacy and tolerability as cefaclor post-intercourse.
  
  
  OBJECTIVE
  To determine the efficacy of prophylaxis in women with recurrent sex induced cystitis and compare the post-intercourse versus the conventional bedtime given long-term, low-dose use of prophylactic antimicrobials.
authors.affiliation: Urology Department, Tzaneion General Hospital Piraeus, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Stamatiou
authors.forename: G
authors.initials: G
authors.lastname: Petrakos
authors.forename: C
authors.initials: C
authors.lastname: Bovis
authors.forename: P
authors.initials: P
authors.lastname: Panagopoulos
authors.forename: A
authors.initials: A
authors.lastname: Economou
authors.forename: C
authors.initials: C
authors.lastname: Karkanis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000627:therapeutic use*; D002433:Cefaclor / Q000008:administration & dosage / Q000627:therapeutic use*; D003556:Cystitis / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008875:Middle Aged; D055502:Secondary Prevention; D012725:Sexual Behavior; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control
chemical_list: D000892:Anti-Infective Agents, Urinary; D002433:Cefaclor; D015662:Trimethoprim, Sulfamethoxazole Drug Combination