An SDF-1 trap for myeloid cells stimulates angiogenesis.
In this issue of Cell, Grunewald et al. (2005) examine the role of hematopoietic cells in the formation of new blood vessels. They show that organ-specific expression of vascular endothelial growth factor (VEGF) is sufficient to mobilize and recruit hematopoietic cells from the bone marrow to the blood, but retention of the proangiogenic subpopulation of hematopoietic cells in peripheral organs requires an additional factor, stromal-derived factor 1 (SDF-1).
Ruiz de Almodovar
Carmen
C
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium.
Luttun
Aernout
A
Carmeliet
Peter
P
D000818:Animals; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology; D022423:Myeloid Cells / Q000187:drug effects / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology / Q000502:physiology
D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D042461:Vascular Endothelial Growth Factor A