title: Oxazaphospholidine-oxide as an efficient ortho-directing group for the diastereoselective deprotonation of ferrocene.
abstract: [reaction: see text] Ortho-lithiation of (2R,4S,5R)-3,4-dimethyl-2-ferrocenyl-5-phenyl[1,3,2]oxazaphospholidine 2-oxide 2 was carried out with diastereoselectivity of >99%, affording a new and efficient way for introducing planar chirality into the ferrocene backbone. Various electrophiles were used to quench the lithiated species, showing the wide applicability of the new ortho-directing group and its potential to generate ligands for use in asymmetric catalysis.
authors.affiliation: Department of Chemistry, University of Liverpool, UK.
authors.forename: Daniele
authors.initials: D
authors.lastname: Vinci
authors.forename: Nuno
authors.initials: N
authors.lastname: Mateus
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wu
authors.forename: Fred
authors.initials: F
authors.lastname: Hancock
authors.forename: Alexander
authors.initials: A
authors.lastname: Steiner
authors.forename: Jianliang
authors.initials: J
authors.lastname: Xiao