Photo-oxidation of sulphanilamide to azo and azoxy compounds.
The second-order kinetics for the photochemical formation of azobenzene-4, 4-disulphonamide has been studied at pH 1-11 and at pH 7.0 in the presence of five antioxidants. The rate constants are not affected by changes in pH in the region of 5-9 at which the molecule is predominantly in the unionised form. The rate of formation of azobenzene-4, 4'-disulphonamide is inhibited upto 80% by ascorbic acid. A scheme for the photo-oxidation of sulphanilamide to the azo and azoxy derivatives has been outlined.
Ahmad
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Ahmad
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