Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose.
A rapidly disintegration tablet in the oral cavity was prepared using a glycine as a disintegrant. Effect of disintegrant on the disintegration behavior of the tablet in the oral cavity was evaluated. Wetting time prepared from carboxymethylcellulose (NS-300) having the hardness of 4 kg was 3 s. Tablet containing NS-300 showed fastest disintegration compared to other formulations. These results suggested that NS-300 possessed excellent wetting nature and resulted in the rapid disintegration of tablet. Ethenzamide and ascorbic acid were added to the formulation, and their disintegration behavior were evaluated. Ethenzamide did not affect the disintegration property, however, ascorbic acid prolonged disintegration time. It was suggested that the tablet formulation containing NS-300 and glycine was highly applicable to water-insoluble drug, such as ethenzamide.
Fukami
Jinichi
J
Kyoto Pharmaceutical Industries Ltd., 38 Nishinokyo, Kyoto 604-8444, Japan.
Yonemochi
Etsuo
E
Yoshihashi
Yasuo
Y
Terada
Katsuhide
K
D001205:Ascorbic Acid / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry*; D006244:Hardness; D007700:Kinetics; D016062:Porosity; D012457:Salicylamides / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D005079:Excipients; D012457:Salicylamides; D013607:Tablets; D014867:Water; D002266:Carboxymethylcellulose Sodium; C018935:ethenzamide; D001205:Ascorbic Acid; D005998:Glycine