[A Case of Cronkhite-Canada syndrome showing resolution with Helicobacter pylori eradication and omeprazole].
We describe a 58-year-old woman who was incidentally found to have gastric and colonic polyposis, hypoalbuminemia, cutaneous hyperpigmentation and onychodystrophy (Cronkhite-Canada syndrome). Histology of polyps from the stomach showed features of juvenile or retention type (hamartomatous) polyps with Helicobacter pylori (H. pylori) infection. The large pedunculated colonic polyps showed hamartomatous polyps with adenomatous component and polypectomy was performed. After the treatment with H. pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed. After the continuous use of omeprazole for 14 months, the patient showed complete resolution of clinical features of Cronkhite-Canada syndrome. The experience of this case suggests that eradication of H. pylori and proton pump inhibitor treatment might be considered in patients with gastric polyposis combined with Cronkhite-Canada syndrome.
Kim
Myung Shin
MS
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
Jung
Hye-Kyung
HK
Jung
Hae Sun
HS
Choi
Ju Young
JY
Na
Yoon Ju
YJ
Pyun
Gun Woo
GW
Ryu
Jung Hwa
JH
Moon
Il Hwan
IH
Jo
Min Sun
MS
D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D003111:Colonic Polyps / Q000150:complications / Q000382:microbiology / Q000473:pathology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D017495:Hyperpigmentation / Q000473:pathology; D008875:Middle Aged; D009264:Nails, Malformed / Q000473:pathology; D009853:Omeprazole / Q000627:therapeutic use*; D011127:Polyps / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D054328:Proton Pump Inhibitors; D013274:Stomach Neoplasms / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D013577:Syndrome
D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D009853:Omeprazole