title: Determination of ceftriaxone sodium in pharmaceutical formulations by flow injection analysis with acid potassium permanganate chemiluminescence detection.
abstract: Based on the chemiluminescence (CL) emission generated from the oxidation of ceftriaxone sodium alkali hydrolysate by potassium permanganate in polyphosphoric acid (PPA), a novel determination method for ceftriaxone sodium was developed by using a flow-injection technique. The calibration curve appears to be linear in the range between 0.05 and 100 microg mL(-1) with a detection limit (3sigma) of 25 ng mL(-1), and a relative standard deviation (RSD) of 0.6% for eleven replicate determinations of 5.0 microg mL(-1) ceftriaxone sodium. The proposed method has been successfully utilized for the determination of ceftriaxone sodium in pharmaceutical formulations, while the chemiluminescence reaction mechanisms were investigated.
authors.affiliation: Institute of Chemistry, Northwest Normal University, Lanzhou 730070, PR China.
authors.forename: Deyi
authors.initials: D
authors.lastname: Zhang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Ma
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
mesh_terms: D002138:Calibration; D002443:Ceftriaxone / Q000032:analysis*; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011196:Potassium Permanganate / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations; D010756:Phosphoric Acids; D011108:Polymers; D011196:Potassium Permanganate; D002443:Ceftriaxone; C047269:polyphosphoric acid