title: Cryosurgery for advanced malignant melanoma of the facial skin. A case report.
abstract: BACKGROUND
  Cryosurgery is safely employed for the treatment of skin precancerous and malignant lesions of the head and neck in selected patients. The case of a 101-year-old female patient with advanced malignant melanoma of the facial skin, undergoing cryosurgery, is reported in order to assess the feasibility and tolerability of the technique, as well as the biological implications of cryosurgical treatment in this specific neoplasm.
  
  
  METHODS
  A 101-year-old woman, with a large (pT4b N0 M0) cutaneous melanoma of the facial skin on the right cheek, was treated at the Division of Surgical Oncology of the National Cancer Research Institute, Italy, from June to August 2003. The treatment was accomplished by means of serial cryosurgical applications which were performed within three months; the bulk of the lesion was cryotreated with a liquid nitrogen cryoprobe, while the residual disease was treated with a nitrous protoxide cryoprobe, by means of the insertion technique. The treatment was well tolerated, with a good aesthetic result, and the patient is recurrence- and distant-disease-free two years after the initial cryosurgical application.
  
  
  CONCLUSIONS
  Cryosurgery is feasible in the treatment of head and neck melanoma, mostly for mucosal melanomas and cutaneous lesions in anatomically critical sites, as well as in high-risk surgical patients. Here, a good aesthetic result was obtained in a very elderly patient with a large cutaneous melanoma of the facial skin, avoiding skin flap transposition for tissue repair and postoperative complications (e.g., serious bleeding or postoperative pain), with a satisfactory functional and oncological outcome at two years.
authors.affiliation: S.C. Oncologia Chirurgica, National Cancer Research Institute, Genoa, Italy. marco.gipponi@unige.it
authors.forename: Marco
authors.initials: M
authors.lastname: Scala
authors.forename: Marco
authors.initials: M
authors.lastname: Gipponi
authors.forename: Paola
authors.initials: P
authors.lastname: Queirolo
authors.forename: Paola
authors.initials: P
authors.lastname: Mereu
authors.forename: Nicola
authors.initials: N
authors.lastname: Solari
authors.forename: Stefano
authors.initials: S
authors.lastname: Monteghirfo
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Cafiero
mesh_terms: D000369:Aged, 80 and over; D003452:Cryosurgery; D005260:Female; D006801:Humans; D008545:Melanoma / Q000601:surgery*; D012878:Skin Neoplasms / Q000601:surgery*; D016896:Treatment Outcome