Inheritance of rupture of the cranial cruciate ligament in Newfoundlands.
OBJECTIVE
To determine prevalence, level of inbreeding, heritability, and mode of inheritance for rupture of the cranial cruciate ligament (RCCL) in Newfoundlands.


METHODS
Retrospective and recruitment study.


METHODS
574 client-owned Newfoundlands.


METHODS
Medical records from January 1, 1996, to December 31, 2002, were evaluated for prevalence of RCCL. A pedigree was constructed by use of recruited Newfoundlands with RCCL status based on results of veterinary examination; level of inbreeding, heritability, and mode of inheritance were calculated.


RESULTS
Hospital prevalence for RCCL was 22%; dogs in the pedigree from the recruitment study had a mean level of inbreeding of 1.19 x 10(4), heritability of 0.27, and a possible recessive mode of inheritance with 51% penetrance for RCCL.


CONCLUSIONS
Identification of a genetic basis for RCCL in Newfoundlands provided evidence that investigators can now focus on developing methods to identify carriers to reduce the prevalence of RCCL.
Wilke
Vicki L
VL
Department of Animal Sciences, Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011-1250, USA.
Conzemius
Michael G
MG
Kinghorn
Brian P
BP
Macrossan
Paula E
PE
Cai
Weiguo
W
Rothschild
Max F
MF
D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D004285:Dogs / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D007178:Inbreeding; D008297:Male; D015995:Prevalence; D012421:Rupture / Q000453:epidemiology / Q000235:genetics / Q000601:surgery / Q000662:veterinary; D014481:United States / Q000453:epidemiology