title: Thermosensitive and mucoadhesive delivery systems of mucosal vaccines.
abstract: Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers.
authors.affiliation: MyGene Bioscience Institute, Kangnam-gu, Seoul, Republic of Korea. ikhan@mygene.net
authors.forename: In-Kwon
authors.initials: IK
authors.lastname: Han
authors.forename: Young Bong
authors.initials: YB
authors.lastname: Kim
authors.forename: Hung-Sik
authors.initials: HS
authors.lastname: Kang
authors.forename: Donggeun
authors.initials: D
authors.lastname: Sul
authors.forename: Woon-Won
authors.initials: WW
authors.lastname: Jung
authors.forename: Hee Jeong
authors.initials: HJ
authors.lastname: Cho
authors.forename: Yu-Kyoung
authors.initials: YK
authors.lastname: Oh
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000281:Administration, Intranasal; D000282:Administration, Intravaginal; D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D000941:Antigens / Q000737:chemistry; D036022:Capsid Proteins / Q000737:chemistry / Q000276:immunology; D002772:Cholera Toxin / Q000737:chemistry / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005782:Gels / Q000737:chemistry; D018928:Immunity, Mucosal / Q000276:immunology*; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000737:chemistry; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000276:immunology; D011060:Poloxalene / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012212:Rheology; D044366:Transition Temperature; D014611:Vaccination / Q000379:methods*; D014621:Vagina / Q000276:immunology / Q000378:metabolism
chemical_list: D000180:Acrylic Resins; D000941:Antigens; D036022:Capsid Proteins; D005782:Gels; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D009856:Oncogene Proteins, Viral; D011092:Polyethylene Glycols; C063317:L1 protein, Human papillomavirus type 16; C030312:calcium polycarbophil; D011060:Poloxalene; D002772:Cholera Toxin