Hemodynamic changes in depressive patients.
OBJECTIVE
This study is aimed at exploring the relationship between hemodynamic changes and depressive and anxious symptom in depression patients.


METHODS
The cardiac function indices including the left stroke index (LSI), ejection fraction (EF), heart rate (HR), diastolic pressure mean (DPM), systolic pressure mean (SPM), left ventricle end-diastolic volume (LVDV), effective circulating volume (ECV), resistance total mean (RTM) and blood flow smooth degree (BFSD) were determined in 65 patients with major depressive disorders and 31 healthy normal controls. The clinical symptoms were assessed with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA).


RESULTS
In patients with depression without anxiety, LSI, EF, LVDV, DPM, SPM, ECV, BFSD were significantly lower than those in controls, while RTM was higher than that in controls. Patients with comorbidity of depression and anxiety showed decreased LVDV, ECV, BFSD, and increased HR in comparison with the controls. The anxiety/somatization factor score positively correlated with LSI, EF, LVDV, but negatively correlated with RTM. There was negative correlation between retardation factor score and DPM, SPM, LVDV.


CONCLUSIONS
The study indicated that there are noticeable changes in left ventricle preload and afterload, blood pressure, peripheral resistance, and microcirculation in depressive patients, and that the accompanying anxiety makes the changes more complicated.
Ma
Ying
Y
Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. maying7211@sina.com
Li
Hui-chun
HC
Zheng
Lei-lei
LL
Yu
Hua-liang
HL
D000328:Adult; D001007:Anxiety / Q000150:complications; D001794:Blood Pressure; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000097:blood* / Q000150:complications; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011569:Psychiatric Status Rating Scales; D013599:Systole; D016277:Ventricular Function, Left