Effect of triturated dilutions of ethanol on the peristaltic contractions of isolated rabbit intestine.
Effect of triturated dilutions of ethanol from to 10(-3) to 10(-24) were studied on the peristaltic contractions of isolated rabbit intestinal pieces. Triturated dilutions of ethanol were applied in two doses. It was generally observed that the addition of first dose was followed by a small increase of 1.1 gms. in the resting tension which occurred at a slower rate in about 36.5 sec. The second doses however, increased the resting tension by 24 gms, in about 21 sec. In addition, the active tensions showed large variations on the application of first doses of triturated ethanol, while the second doses always decreased this parameter below the first dose levels. The rate of contractions was however, unaltered by both the first and second doses of ethanol, although an increase in the contraction times was found to be balanced by a simultaneous decrease either in the peak duration or relaxation times. The results are discussed in terms of electrophysiological, active state and free ionic Ca++ release phenomena.
Nasreen
R
R
Department of Pharmacology, University of Karachi, Karachi-75270, Pakistan.
Shaikh
H A
HA
Ali
S T
ST
Ahmad
S I
SI