[Today's tuberculosis: the specific features of its pathogen, clinical picture, and treatment].
Clinical Mycobacterium tuberculosis (MBT) strains (their genotype, drug resistance, and virulence) and the characteristics of their caused processes were studied. More than a half the studied MBT isolates belonged to the genetic family Beijing. As compared with mycobacteria of individual genotypes, they showed a significantly higher rate of multidrug resistance, polyresistance, and a high virulescence and caused more common and frequently progressive pulmonary lesions requiring the use of large-dose isoniazid and second-line drugs and early surgical treatment.
Skvortsova
L A
LA
Pavlova
M V
MV
Sapozhnikova
n V
nV
Veshnevskiĭ
B I
BI
Narvskaia
O V
OV
D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification*; D011110:Polymorphism, Genetic / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000235:genetics / Q000382:microbiology*
D000904:Antibiotics, Antitubercular