Genetics of early mammalian folliculogenesis.
Early ovarian folliculogenesis begins with the breakdown of germ cell clusters and formation of primordial follicles. Primordial follicles are the smallest ovarian follicle units continuously recruited to grow into primary and more advanced ovarian follicles. Genes expressed in the germ cells such as Figla, Nobox, Kit and Ntrk2, as well as genes expressed in the surrounding somatic cells such as Foxl2, Kitl and Ngf, play critical functions during early folliculogenesis. Transgenic mice continue to provide important insights into the genetic pathways that regulate early mammalian folliculogenesis. Genes critical in early folliculogenesis are important determinants of reproductive life span and represent candidate genes for human ovarian failure.
Choi
Y
Y
Department of Obstetrics and Gynecology, Baylor College of Medicine, Faculty Center, 1709 Dryden Street, Suite 1100, Houston 77030, USA.
Rajkovic
A
A
D000818:Animals; D054304:Anti-Mullerian Hormone; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D006080:Ovarian Follicle / Q000166:cytology* / Q000196:embryology / Q000378:metabolism*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism; D019089:Stem Cell Factor / Q000235:genetics / Q000378:metabolism; D013735:Testicular Hormones / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D054304:Anti-Mullerian Hormone; D051792:Basic Helix-Loop-Helix Proteins; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; D006023:Glycoproteins; D006133:Growth Substances; D018398:Homeodomain Proteins; D019009:Proto-Oncogene Proteins c-kit; D019089:Stem Cell Factor; D013735:Testicular Hormones; D014157:Transcription Factors; C109920:Figla protein, mouse; C498893:Foxl2 protein, mouse; C456265:Og2x protein, mouse