Influence of endogenous glutathione level on X-ray induced cell cycle delay in human lymphocytes.
Here, induction of chromosomal aberration after X-irradiation and the pattern of cell cycle kinetics have been investigated in human lymphocytes, after exogenous addition of reduced glutathione or by depleting levels of reduced glutathione endogenously. Involvement of cell cycle regulator proteins such as p53 and p21 has been investigated to elucidate their role in induction of delay in cell cycle progression after irradiation.
Ray
S
S
Genetics Laboratory, Department of Biotechnology and Bioinformatics, North-Eastern Hill University, Shillong, India.
Chatterjee
A
A
D002453:Cell Cycle / Q000528:radiation effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000528:radiation effects; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D012854:Sister Chromatid Exchange; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*; D014965:X-Rays
D050759:Cyclin-Dependent Kinase Inhibitor p21; D016159:Tumor Suppressor Protein p53; D005978:Glutathione