[Combined (chemo-radiation) treatment of patients with nasopharyngeal cancer].
The efficacy of parallel and successive chemoradial treatment of patients with nasopharynx carcinoma was investigated in the radiological center of Burdenko MMCH. The main group consisted of 42 patients, the control group included 44 patients. They were from 21 to 78 years old. 71% of the patients had the 3rd and the 4th stages of the tumor process; 29% had the 1st and the 2nd stages; 68,6% had the metastatic nodal involvement of regional zones. The radial therapy of the locoregional zone was administered by means of the splitting course using the classic method of fractionating a dose up to the total optimal dose of 64-70 Gr. Polychemotherapy consisted of 6 courses cisplatin, farmarubicin, and platinum. Due to the treatment the 5-year survival rate increased from 41,2% to 78,5% (P < 0,001). With the metastatic nodal involvement of regional zones that rate reduced from 83,3% to 72,8% (P > 0,05) in the main group and from 63,8% to 31,9% (P < 0,001) in the control group.
Seriakov
A P
AP
Kopychev
Iu E
IuE
Gorbunov
V A
VA
Zav'ialov
M S
MS
Kubyshkin
S I
SI
Smolin
A V
AV
Sukirko
V A
VA
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011829:Radiation Dosage
D015251:Epirubicin; D002945:Cisplatin; D005472:Fluorouracil