title: Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior.
abstract: BACKGROUND
  Abnormalities in the serotonergic (5-HT) system have been implicated in the pathogenesis of suicidal behavior. Studies on peripheral serotonergic parameters as a measure for central serotonergic function in suicidal patients appear to be promising, yet failed to show a clear association with suicidality. The objective of this study was to elucidate the role of serotonergic blood parameters in depressed suicidal patients and to examine their usefulness as a potential biological marker for suicidality. A number of personality traits were assessed in order to provide a basis for a psychobiological model of suicidal behavior.
  
  
  METHODS
  Depressed patients with a recent suicide attempt (SA; n = 59) were compared to those without history of suicide attempts (NSA; n = 28). 5-HT2A receptor binding in platelets and tryptophan/amino acid ratio in plasma were measured. Acute psychopathology and personality traits as well as characteristics of suicide attempts were assessed.
  
  
  RESULTS
  There was no significant difference between SA and NSA in terms of peripheral serotonergic parameters as well as personality traits. However, the whole sample showed associations between certain personality traits and serotonergic platelet parameters. Furthermore, we observed a relation between suicidal ideation, lethality of suicide attempts and peripheral serotonergic markers.
  
  
  CONCLUSIONS
  The number of cases with data on peripheral markers is relatively low. The potential influence of antidepressant medication previous to study inclusion has to be taken into account. The study focussed on depressed patients only.
  
  
  CONCLUSIONS
  Low serotonergic function is involved in the pathogenesis of suicidality, whereas the use of platelet 5-HT2A receptor activity and tryptophan availability as biological markers for suicidality in depressed patients could not be proven an appropriate tool. Alterations in the serotonergic system are associated with trait aggression and other character dimensions.
authors.affiliation: University of Schleswig-Holstein, Campus Luebeck, Department of Psychiatry and Psychotherapy, Ratzeburger Allee 160, 23538 Luebeck, Germany. lauterbach.e@psychiartry.uni-luebeck.de
authors.forename: Erik
authors.initials: E
authors.lastname: Lauterbach
authors.forename: Jürgen
authors.initials: J
authors.lastname: Brunner
authors.forename: Barbara
authors.initials: B
authors.lastname: Hawellek
authors.forename: Ute
authors.initials: U
authors.lastname: Lewitzka
authors.forename: Marcus
authors.initials: M
authors.lastname: Ising
authors.forename: Brigitta
authors.initials: B
authors.lastname: Bondy
authors.forename: Marie Luise
authors.initials: ML
authors.lastname: Rao
authors.forename: Christine
authors.initials: C
authors.lastname: Frahnert
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.forename: Bruno
authors.initials: B
authors.lastname: Müller-Oerlinghausen
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schley
authors.forename: Isabella
authors.initials: I
authors.lastname: Heuser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Fritz
authors.initials: F
authors.lastname: Hohagen
authors.forename: Werner
authors.initials: W
authors.lastname: Felber
authors.forename: Thomas
authors.initials: T
authors.lastname: Bronisch
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood* / Q000523:psychology; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment / Q000706:statistics & numerical data*; D011594:Psychometrics; D011869:Radioligand Assay; D044402:Receptor, Serotonin, 5-HT2A / Q000097:blood*; D012306:Risk; D013223:Statistics as Topic; D013406:Suicide, Attempted / Q000523:psychology*; D014364:Tryptophan / Q000097:blood*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D044402:Receptor, Serotonin, 5-HT2A; D014364:Tryptophan