Intracranial gliofibroma mimicking a meningioma: a case report and review of literature.
Gliofibromas are rare glio-mesenchymal tumors composed of astrocytic and benign mesenchymal components, which commonly occur in the first two decades of life. They are not listed as a distinct entity in the current WHO classification of CNS tumors. Their biological behaviour is unknown, and histogenesis is debatable. We describe a case of histopathologically proven gliofibroma in the region of the left quadrigeminal plate in a 15-year-old child that mimicked a tentorial meningioma both at imaging and surgery. Post-operatively, the residual tumor regrew to a size similar to the initial mass (4 cm x 3.6 cm x 3.5 cm), within one and a half years after the first surgery. The histopathology of the tumor was similar on both occasions. Although a poor prognosis has been characteristically noted in gliofibromas with high-grade glial component, but the present case had recurrence despite being of low-grade, thus highlighting the uncertain behaviour of this rare tumor.
Deb
Prabal
P
Department of Pathology, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi 110029, India.
Sarkar
Chitra
C
Garg
Ajay
A
Singh
Virender Pal
VP
Kale
Shashank Sharad
SS
Sharma
Mehar Chand
MC
D000293:Adolescent; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000175:diagnosis* / Q000601:surgery; D005910:Glioma / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008579:Meningioma / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery; D020542:Third Ventricle