[The course of chronic glomerulonephritis in chronic opisthorchiasis].
OBJECTIVE
To characterize clinical, functional and morphological features of chronic glomerulonephritis (CGN) running with chronic opisthorchiasis (CO) and to justify dehelminthization.


METHODS
Clinical, functional and morphological examinations of the kidneys, immunological characteristics were studied in 100 patients with primary CGN and CO (group 1), 30 patients with CGN free of CO (group 2) and 40 patients with long-term CO.


RESULTS
CGN in CO runs with frequent rise of creatinine, glomerular filtration and canal reabsorption fall. Pathogenetic therapy with addition of pulse cyclophosphamide in a dose 10 mg/kg and conduction of dehelminthization a year later lead to long-term remission and inhibition of nephrosclerosis development.


CONCLUSIONS
Clinicofunctional and morphological characteristics of the kidneys in mixed pathology necessitate addition of immunosuppressor cyclophosphamide in a dose 10 mg/kg and dehelminthization in combined treatment of patients with glomerulonephritis and opisthorchiasis.
Beloborodova
E I
EI
Zibnitskaia
L I
LI
Kaliuzhina
E V
EV
D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005921:Glomerulonephritis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D009400:Nephrosclerosis / Q000150:complications / Q000517:prevention & control; D009889:Opisthorchiasis / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
D003520:Cyclophosphamide; D003404:Creatinine