title: Polyplex-embedding in polyelectrolyte multilayers for gene delivery.
abstract: In this work, incorporation of plasmid DNA, pre-complexed with PEI, into polyelectrolyte multilayers has been studied to further develop platforms for local gene delivery. Polyplex embedding in synthetic and naturally degradable architectures was efficient for transfection of human hepato-cellular carcinoma cells.
authors.affiliation: Inserm Unité 595, 11 rue Humann, F-67085 Strasbourg, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Meyer
authors.forename: Vincent
authors.initials: V
authors.lastname: Ball
authors.forename: Pierre
authors.initials: P
authors.lastname: Schaaf
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Voegel
authors.forename: Joelle
authors.initials: J
authors.lastname: Ogier
mesh_terms: D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D006801:Humans; D008113:Liver Neoplasms; D010957:Plasmids / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D014162:Transfection / Q000379:methods*
chemical_list: D004573:Electrolytes; D011094:Polyethyleneimine; D004247:DNA