title: Reversible photoregulation of helical structures in short peptides under indoor lighting/dark conditions.
abstract: [reaction: see text] A photochromic cross-linking agent with a spiropyran skeleton was developed for the reversible photoregulation of helical structures in short peptides. The helical contents of the cross-linked peptides could be regulated by ambient light and dark conditions at room temperature. This switching of the helical contents could be repeated several times without substantial loss of any activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Toyama, Japan. fujimoto@ms.toyama-mpu.ac.jp
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Miwo
authors.initials: M
authors.lastname: Amano
authors.forename: Yohei
authors.initials: Y
authors.lastname: Horibe
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inouye
mesh_terms: D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D010777:Photochemistry; D017433:Protein Structure, Secondary; D013329:Structure-Activity Relationship
chemical_list: D003432:Cross-Linking Reagents; D010455:Peptides