title: Acute effects of hyperoxemia on dyspnoea and respiratory variables during pressure support ventilation.
abstract: OBJECTIVE
  To evaluate the acute effect of hyperoxemia on the comfort and the respiratory variables in patients undergoing pressure support ventilation (PSV) for acute respiratory failure (ARF).
  
  
  METHODS
  Prospective, observational study performed in the intensive care unit of a university hospital.
  
  
  METHODS
  Thirteen semirecumbent patients were ventilated in PSV mode, the setting of which was established by the treating physician who was blinded to the study.
  
  
  METHODS
  The variables measured at different levels (21-80%) of FiO(2) randomly applied were: minute volume (V (E)), respiratory frequency (f) and the pressure develing during the first 100 ms of an occluded breath (P(0.1)). These variables were firstly measured at the level of FiO(2) chosen by the treating physician. Severity of dyspnea was rated using the visual analogue scale 15' after each FiO(2) variation.
  
  
  RESULTS
  Modulation of FiO(2) was able to vary significantly the respiratory variables, since a FiO(2) increase was associated with a decrease in dyspnea, P(0.1), f, and V (E). While valuable variations were detected at both lower and higher values of FiO(2) than those established by the treating physician, a significant improvement in the respiratory variables was detected at FiO(2) 60%. The reduction in respiratory drive was statistically related to an amelioration of dyspnea (R(2)=0.89) even at values of FiO(2) higher than 60%.
  
  
  CONCLUSIONS
  During PSV the respiratory drive can be heavily modulated by varying the FiO(2) since even at FiO(2) greater than 0.6 dyspnea and respiratory variables continued to improve.
authors.affiliation: Department of Surgical, Anesthesiological and Radiological Science.Section of Anesthesia and Intensive Care, S.Anna Hospital, University of Ferrara, Corso Giovecca 203, 44100, Ferrara, Italy. vlc@unife.it.
authors.forename: Carlo Alberto
authors.initials: CA
authors.lastname: Volta
authors.affiliation: Department of Surgical, Anesthesiological and Radiological Science.Section of Anesthesia and Intensive Care, S.Anna Hospital, University of Ferrara, Corso Giovecca 203, 44100, Ferrara, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Alvisi
authors.affiliation: Department of Surgical, Anesthesiological and Radiological Science.Section of Anesthesia and Intensive Care, S.Anna Hospital, University of Ferrara, Corso Giovecca 203, 44100, Ferrara, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Bertacchini
authors.affiliation: Department of Surgical, Anesthesiological and Radiological Science.Section of Anesthesia and Intensive Care, S.Anna Hospital, University of Ferrara, Corso Giovecca 203, 44100, Ferrara, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Marangoni
authors.affiliation: Department of Surgical, Anesthesiological and Radiological Science.Section of Anesthesia and Intensive Care, S.Anna Hospital, University of Ferrara, Corso Giovecca 203, 44100, Ferrara, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ragazzi
authors.affiliation: Department of Surgical, Anesthesiological and Radiological Science.Section of Anesthesia and Intensive Care, S.Anna Hospital, University of Ferrara, Corso Giovecca 203, 44100, Ferrara, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Verri
authors.affiliation: Department of Surgical, Anesthesiological and Radiological Science.Section of Anesthesia and Intensive Care, S.Anna Hospital, University of Ferrara, Corso Giovecca 203, 44100, Ferrara, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Alvisi
mesh_terms: D000704:Analysis of Variance; D004417:Dyspnea / Q000503:physiopathology; D006801:Humans; D010100:Oxygen / Q000097:blood*; D011446:Prospective Studies; D012044:Regression Analysis; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy*; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D010100:Oxygen