Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005.
BACKGROUND
In 1997, a Monograph from the International Agency for Research on Cancer (IARC) classified occupational exposure to crystalline silica as carcinogenic to humans. Large amounts of epidemiological data have been published subsequently.


METHODS
We conducted a systematic review of epidemiological investigations on silica exposure and lung cancer risk published after the IARC Monograph, including 28 cohort, 15 case-control and two proportionate mortality ratio (PMR) studies. These were identified in the available literature.


RESULTS
The pooled RR of lung cancer, calculated using random effects models, from all cohort studies considering occupational exposure to silica was 1.34. The RRs were 1.69 in cohort studies of silicotics only, 1.25 in studies where silicosis status was undefined and 1.19 among non silicotic subjects. The pooled RR was 1.41 for all case-control studies. The RRs were 3.27 in case-control studies of silicotics only, 1.41 in studies where silicosis status was undefined and 0.97 among non silicotic subjects. The RR was 1.24 for PMR studies.


CONCLUSIONS
In this re-analysis, the association with lung cancer was consistent for silicotics, but the data were limited for non silicotic subjects and not easily explained for undefined silicosis status workers. This leaves open the issue of dose-risk relation and pathogenic mechanisms and supports the conclusion that the carcinogenic role of silica per se in absence of silicosis is still unclear.
Pelucchi
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Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy. pelucchi@marionegri.it
Pira
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Piolatto
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Coggiola
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Carta
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La Vecchia
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D016022:Case-Control Studies; D015331:Cohort Studies; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects*; D018570:Risk Assessment; D012822:Silicon Dioxide / Q000009:adverse effects*; D012829:Silicosis / Q000150:complications* / Q000453:epidemiology
D012822:Silicon Dioxide