title: A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273.
abstract: A novel ketone derivative of artemisinin, artemisitone-9, was produced by the biotransformation of cultured Streptomyces griseus ATCC 13273. The structure of the ketone product was fully elucidated by various spectroscopic techniques, and the mechanism of generating such novel metabolite is also discussed.
authors.affiliation: Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 210038, People's Republic of China.
authors.forename: Ji-Hua
authors.initials: JH
authors.lastname: Liu
authors.forename: You-Gen
authors.initials: YG
authors.lastname: Chen
authors.forename: Bo-Yang
authors.initials: BY
authors.lastname: Yu
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Chen
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism*; D037621:Artemisinins / Q000737:chemistry / Q000378:metabolism*; D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013305:Streptomyces griseus / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin