title: [Effect of vitamin C antioxidative protection on human red blood cells].
abstract: In order to investigate the effect of antioxidants on human blood, vitamin C was selected and added into plastic blood storage bags with CPD, and stored at 25 degrees C. During 6 days of storage, some indexes as ATP, SOD, MDA, K(+) concentration and superoxide radicals were detected and were compared with control group, The results showed that ATP and SOD activity in whole blood with vitamin C during 6 days of storage was higher then that in control group (P < 0.05, P < 0.01), the MDA and plasma K(+) concentrations in stored whole blood with vitamin C during 6 days of storage were lower than that in control group (P < 0.05, P < 0.01), the superoxide radical concentrations in stored whole blood with vitamin C decreased lower than that in control group (30%). The conclusion was made that vitamin C increases activities of ATP and SOD, decreases concentrations of MDA, plasma K(+) and superoxide radicals during blood preservation.
authors.affiliation: Blood Center of Jiangsu Province, Nanjing 210042, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zan
authors.forename: Jing
authors.initials: J
authors.lastname: Tao
authors.forename: Rong-Cai
authors.initials: RC
authors.lastname: Tang
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Huang
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Zhou
authors.forename: Min-Hui
authors.initials: MH
authors.lastname: Wu
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Liu
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001793:Blood Preservation / Q000379:methods*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D011188:Potassium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D013482:Superoxide Dismutase; D001205:Ascorbic Acid; D011188:Potassium