title: The role of matrix metalloproteinase 9 in early neurological worsening of acute lacunar infarction.
abstract: The involvement of matrix metalloproteinases (MMPs) in ischemic-stroke-induced inflammatory response has recently been suggested; however, the relationship between MMPs and stroke progression has not been evaluated. We investigated the role of MMPs in neurological worsening of acute lacunar infarction. Forty-nine consecutive patients with an acute lacunar infarction (as defined by clinical and MRI criteria within 48 h after stroke onset) were evaluated. Clinical, biochemical, rheological, inflammatory and other parameters were compared between progressive and nonprogressive groups. Among the variables, only inflammatory parameters, including MMP-9 and erythrocyte sedimentation rate, were associated with neurological worsening of acute lacunar infarction (p<0.05). These results suggest that the inflammatory process could play an important role in early neurological worsening of acute lacunar infarction.
authors.affiliation: Department of Neurology, College of Medicine, Hanyang University, Seoul, South Korea.
authors.forename: Young Seo
authors.initials: YS
authors.lastname: Kim
authors.forename: Kyu-Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Koh
authors.forename: Chang Yun
authors.initials: CY
authors.lastname: Park
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hee Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Juhan
authors.initials: J
authors.lastname: Kim
authors.forename: Myung-Ho
authors.initials: MH
authors.lastname: Kim
authors.forename: Kyung Suk
authors.initials: KS
authors.lastname: Kim
authors.forename: Dae-il
authors.initials: DI
authors.lastname: Chang
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000368:Aged; D001799:Blood Sedimentation; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D020520:Brain Infarction / Q000175:diagnosis / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000502:physiology*; D008875:Middle Aged; D009460:Neurologic Examination; D011379:Prognosis; D012307:Risk Factors
chemical_list: D020780:Matrix Metalloproteinase 9