title: A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest.
abstract: Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.
authors.affiliation: Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Ujiki
authors.forename: Ben
authors.initials: B
authors.lastname: Milam
authors.forename: Xian-Zhong
authors.initials: XZ
authors.lastname: Ding
authors.forename: Alexandra B
authors.initials: AB
authors.lastname: Roginsky
authors.forename: M Reza
authors.initials: MR
authors.lastname: Salabat
authors.forename: Mark S
authors.initials: MS
authors.lastname: Talamonti
authors.forename: Richard H
authors.initials: RH
authors.lastname: Bell
authors.forename: Wenxin
authors.initials: W
authors.lastname: Gu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Silverman
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Adrian
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D047630:Depsipeptides / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; C119376:sansalvamide A