Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia.
OBJECTIVE
We determined whether single nucleotide polymorphisms (SNPs) in interleukin-6 (IL-6), hepatic lipase (HL) and calpain-10 (CAPN-10) genes contribute to susceptibility to develop preeclampsia.


METHODS
The study involved 133 preeclamptic and 115 healthy pregnant women who were genotyped for the C-174G polymorphism in the IL-6 gene, the G-250A polymorphism in the HL gene and SNP 43 (G/A) in the CAPN-10 gene. The chi2-test was used to assess genotype and allele frequency differences between the preeclamptic and control groups.


RESULTS
No significant differences were detected in genotype and allele distributions of the C-174G polymorphism in the IL-6 gene, between the preeclampsia and control groups (p=0.98 and 0.85, respectively). With respect to the G-250A polymorphism in the HL gene, the genotype and allele distributions were similar in both groups (p=0.64 and 0.48, respectively). The genotype and allele distributions of SNP 43 in the CAPN-10 gene also showed no statistical differences in the preeclampsia and control groups (p=0.73 and 0.45, respectively).


CONCLUSIONS
The C-174G polymorphism in the IL-6 gene, the G-250A polymorphism in the HL gene and SNP 43 (G/A) in the CAPN-10 gene are unlikely to be major genetic factors predisposing Finnish women to preeclampsia.
Saarela
Tanja
T
Department of Obstetrics and Gynecology, University of Kuopio, Finland.
Hiltunen
Mikko
M
Helisalmi
Seppo
S
Heinonen
Seppo
S
Laakso
Markku
M
D000328:Adult; D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008049:Lipase / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
D015850:Interleukin-6; C504173:LIPC protein, human; D008049:Lipase; D002154:Calpain; C415197:calpain 10