[Pharmacokinetic study of intraperitoneal chemotherapy with HCPT].
OBJECTIVE
To study the pharmacokinetic of 10-Hydroxycamptothecin HCPT by intraperitoneal administration.


METHODS
Six dogs were given HCPT by intraperitoneal perfusion: HCPT 2 mg x kg(-1), dissolved in 300 mL NS. During the course of experiments, peritoneal fluids and blood were sampled using a standardized protocol. The concentration of HCPT in all samples was determined by high performance liquid chromatography (HPLC).


RESULTS
The area under the curve (AUC) of peritoneal fluids was significantly highly as compared to the AUC of femoral vein and portal vein (P < 0.001).


CONCLUSIONS
These experiments demonstrate that intraperitoneal chemotherapy has significant effect on the pharmacokinetics of IP route of HCPT administration. This method should be a more reasonable chemotherapy for the prevention of recurrence and liver metastasis of gastric cancer, colon cancer and ovary cancer after radical resection.
Ye
Meng
M
Oncology center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China.
Lin
Xiao-xia
XX
Pan
Hong-ming
HM
Li
Nan
N
Lou
Fang
F
Jin
Wei
W
Zheng
Yu
Y
Wu
Jing-min
JM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001202:Ascitic Fluid / Q000378:metabolism*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004285:Dogs; D007263:Infusions, Parenteral; D008297:Male
D000972:Antineoplastic Agents, Phytogenic; C028098:10-hydroxycamptothecin; D002166:Camptothecin