Mechanisms of increased acid secretion after eradication of Helicobacter pylori infection.
Eradication of Helicobacter pylori infection leads to recovery of gastric acid secretion in some individuals but the mechanism is not fully understood. In the short term, there is an impressive increase in expression of H+/K+-ATPase pumps without an increase in the number of parietal cells. Longer follow up studies are needed to see if the parietal cell mass eventually recovers.
El-Omar
E M
EM
Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK. e.el-omar@abdn.ac.uk
D005744:Gastric Acid / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase / Q000502:physiology; D016481:Helicobacter Infections / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D016480:Helicobacter pylori; D006801:Humans; D010295:Parietal Cells, Gastric / Q000473:pathology
D017506:H(+)-K(+)-Exchanging ATPase