[Significances of serum level and immunohistochemical stain of CA19-9 in simple hepatic cysts and intrahepatic biliary cystic neoplasms].
OBJECTIVE
In spite of various diagnostic modalities, biliary cystic neoplasms (biliary cystadenoma and cystadenocarcinoma) remain to be difficult to diagnose preoperatively. Recently, there are some reports that elevated CA19-9 level in serum and/or cystic fluid could be a useful finding in the differential diagnosis of biliary cystic neoplasm. This study aimed to evaluate the expression of CA19-9 and to elucidate its significances in intrahepatic biliary cystic neoplasms and simple hepatic cysts.


METHODS
In 8 patients with biliary cystic neoplasms and 6 simple hepatic cysts, symptoms, radiologic and laboratory findings were reviewed retrospectively. In 5 biliary cystic neoplasms (4 biliary cystadenomas, 1 biliary cystadenocarcinoma) and 5 simple hepatic cysts, immunohistochemical stainings for CA19-9 were performed with formalin-fixed, paraffin-embedded tissues.


RESULTS
In 8 biliary cystic neoplasms, two cases were suspected as biliary cystadenoma preoperatively and 6 cases could not be distinguished from simple cysts or cholangiocarcinoma preoperatively. In 6 simple hepatic cysts, 3 cases were diagnosed preoperatively and 3 cases could not be distinguished from biliary cystadenoma or pancreatic pseudocyst preoperatively. Expression of CA19-9 in simple hepatic cysts and biliary cystic neoplasms were 80% in both groups. Expression of CA19-9 is not related to the elevated level of CA19-9 in serum.


CONCLUSIONS
Our data suggests that the elevated level of CA19-9 in serum may not be helpful in the preoprative diagnosis of biliary cystic neoplasm.
Park
Ki Ho
KH
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Kim
Jae Seon
JS
Lee
Ju Han
JH
Kim
Hyo Jung
HJ
Kim
Jin Yong
JY
Yeon
Jong Eun
JE
Park
Jong-Jae
JJ
Byun
Kwan Soo
KS
Bak
Young-Tae
YT
Lee
Chang Hong
CH
D000328:Adult; D000368:Aged; D001661:Biliary Tract Neoplasms / Q000175:diagnosis*; D018395:CA-19-9 Antigen / Q000032:analysis* / Q000097:blood; D003536:Cystadenocarcinoma / Q000175:diagnosis*; D003537:Cystadenoma / Q000175:diagnosis*; D003560:Cysts / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008107:Liver Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
D018395:CA-19-9 Antigen