Synthesis of some phenacyl derivatives of 1-methyl-7-methoxy-beta-carboline and their behavioural study.
In the present study two phenacyl derivatives of Harmaline; 2-(7-Methoxy-1-methyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-1-(3-nitro-phenyl)-ethanone and 1-(3,4-Dihydroxy-phenyl)-2-(7-methoxy-1-methyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-ethanone were synthesized and evaluated for their effect on behaviour of mice, only meta-nitro phenacyl derivative showed activity, which can be compared with parent compound.
Saify
Z S
ZS
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Farhad
Jawaid
J
Mushtaq
Nousheen
N
Noor
Fozia
F
Takween
Shamoona
S
Akhtar
Shamim
S
Hussain
Waqar
W
Hussain
Shaheen A
SA
Khan
Khalid M
KM