[Orthogonal experiments to select spraying granulation technique for Baoshen granules].
OBJECTIVE
To raise the end-product and economical efficiency of spraying granulation, we demand screening preparation technique.


METHODS
Adopting newly spraying granulation technique, taking extracting technique, adhesive material, temperature of exit and entry,and the matching of accessories as inspecting factors, two levels of each factors, end-product as inspecting marker, we selected the best Baoshen granules preparation technique by orthogonal design.


RESULTS
Among the 4 factors, adhesive material is most notable, next is temperature of exit and entry, the other two is of little importance.


CONCLUSIONS
The optimum spraying granulation technique of Baoshen granules is A2B1C2D1.
Qu
Cai-hong
CH
The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. hong-0601@sina.com
Yang
Li
L
Huang
Ji-wei
JW
Zheng
Qiong-liang
QL
D000269:Adhesives; D003505:Cyclodextrins; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D011208:Powders; D013696:Temperature
D000269:Adhesives; D003505:Cyclodextrins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011208:Powders