Comparative antiplasmodial, leishmanicidal and antitrypanosomal activities of several biflavonoids.
The antiplasmodial, leishmanicidal and antitrypanosomal activities of eight natural biflavonoids were estimated in vitro on a chloroquine-resistant strain of Plasmodium falciparum, axenically grown Leishmania donovani amastigotes and Trypanosoma cruzi trypomastigotes and Trypanosoma brucei rhodesiense bloodstream forms. Lanaroflavone showed the highest antiplasmodial activity (IC(50) = 0.48 microM), isoginkgetin was the most active leishmanicidal compound (IC(50) = 1.9 microM), whereas ginkgetin (IC(50) = 11 microM) and isoginkgetin (IC(50) = 13 microM) showed the best antitrypanosomal activity in our assays. The cytotoxicity and the selectivity indices for the most active compounds were also estimated. Lanaroflavone exhibited a high selectivity index value (SI = 159), indicating selective antiplasmodial activity.
Weniger
B
B
Pharmacognosie et Biomolécules Naturelles Actives, UMR no 7081, Faculté de Pharmacie, Université Louis Pasteur Strasbourg, Illkirch, France.
Vonthron-Sénécheau
C
C
Kaiser
M
M
Brun
R
R
Anton
R
R
D000818:Animals; D044946:Biflavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured; D007893:Leishmania donovani / Q000187:drug effects*; D032342:Muscle Cells / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects*; D051381:Rats; D012015:Reference Standards; D018675:Toxicity Tests; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D044946:Biflavonoids