title: Neuromagnetic responses to vowels vs. tones reveal hemispheric lateralization.
abstract: OBJECTIVE
  To evaluate whether a simple auditory paradigm could demonstrate a difference in cortical lateralization between right- and left-handed subjects. Such information would be important for later development of clinical noninvasive tests of hemispheric language dominance in candidates for brain surgery.
  
  
  METHODS
  Healthy subjects (10 strongly right-handed, 10 strongly left-handed, 5 weakly right-handed, and two ambidextrous) listened to binaural pairs of tones and pairs of Finnish vowels and decided whether the items in the pair were the same (target probability 20%). Cortical responses were recorded with whole-scalp magnetoencephalography.
  
  
  RESULTS
  The laterality index for strengths of the auditory-cortex 100 ms responses (N100m) to vowels vs. tones suggested left-hemispheric dominance in 8 of the 10 strongly right-handed subjects, and right-hemispheric dominance in 7 of the 10 left-handed subjects.
  
  
  CONCLUSIONS
  Our results demonstrate difference in hemispheric dominance for processing of vowels between right-handed and left-handed subjects. This difference resembles language lateralization suggested by previous invasive studies as well as by anatomical and functional comparisons in left- and right-handed subjects.
  
  
  CONCLUSIONS
  After comparison with the Wada test, this simple paradigm could prove useful as a noninvasive test for language lateralization in clinical settings.
authors.affiliation: Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Otakaari 3A, P.O. Box 2200, FIN-02015 HUT, Espoo, Finland. erika@neuro.hut.fi
authors.forename: E
authors.initials: E
authors.lastname: Kirveskari
authors.forename: R
authors.initials: R
authors.lastname: Salmelin
authors.forename: R
authors.initials: R
authors.lastname: Hari
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged