Phosphatidylserine and signal transduction: who needs whom?
The plasma membrane, long considered a simple barrier between the extracellular and intracellular compartments, is now thought to play a pivotal role in many physiological processes that regulate the communication of cells with their environment. On one hand, the plasma membrane directly participates in intracellular signaling; on the other hand, changes in membrane structure contribute to the transcellular transfer of biological information. Among the membrane constituents, phosphatidylserine is a major actor implicated in these effects. Evidence now exists for a role for phosphatidylserine redistribution in modulating the activities of several membrane proteins during signaling in nonapoptotic T lymphocytes.
Martínez
M Carmen
MC
Unité 143 INSERM and Institut d'Hématologie et d'Immunologie, Faculté de Médecine, Université Louis Pasteur, 67085 Strasbourg, France.
Kunzelmann
Corinne
C
Freyssinet
Jean-Marie
JM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology; D001773:Blood Cells / Q000378:metabolism / Q000648:ultrastructure; D001777:Blood Coagulation / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000648:ultrastructure; D006474:Hemorrhagic Disorders / Q000097:blood / Q000235:genetics; D017136:Ion Transport / Q000502:physiology; D008563:Membrane Lipids / Q000502:physiology*; D021962:Membrane Microdomains; D010718:Phosphatidylserines / Q000502:physiology*; D049294:Phospholipid Transfer Proteins / Q000502:physiology; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000502:physiology; D058486:Receptors, Purinergic P2X7; D015398:Signal Transduction / Q000502:physiology*; D012964:Sodium / Q000378:metabolism; D013577:Syndrome; D013601:T-Lymphocytes / Q000378:metabolism / Q000648:ultrastructure
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008563:Membrane Lipids; D010718:Phosphatidylserines; D049294:Phospholipid Transfer Proteins; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D012964:Sodium; D002118:Calcium