Erdheim-Chester's disease of the heart: a diagnostic conundrum and collision with the same mass in the orbit.
Erdheim-Chester's disease is a rare multisystem xanthogranulomatosis, afflicting the skeletal system with the occasional involvement of soft tissues. We delineate an unusual case of a cardiac variant of Erdheim-Chester's disease presenting with pericardial effusion and as a collision with a synchronous orbital manifestation. We describe our diagnostic pathway and propose a novel treatment option involving nonsteroidal anti-inflammatory drugs. The role of cyclo-oxygenase in the disease process and inhibition thereof by NSAIDs is hypothesized and discussed.
Bogáts
Gábor
G
Division of Cardiac Surgery, Center for Cardiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Piros
Györgyi
G
Tiszlavicz
László
L
Iványi
Béla
B
Sasi
Viktor
V
Csepregil
László
L
Simon
Judit
J
Babik
Barna
B
Csillik
Andrea
A
Kardos
Lilla
L
Palkó
András
A
Matin
Keyvan
K
Hanzély
Zoltán
Z
Korányi
Katalin
K
Nyáry
István
I
Végh
Mihály
M
Kolozsvári
Lajos
L
Kahán
Zsuzsanna
Z
Bajcsay
András
A
Tóth
Attila
A
Balázs
György
G
Simor
Tamás
T
Pávics
László
L
Palotás
András
A
D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D031249:Erdheim-Chester Disease / Q000175:diagnosis / Q000188:drug therapy*; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy*; D011720:Pyrazoles / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib