Are blood cultures necessary in the management of women with complicated pyelonephritis?
OBJECTIVE
Data from previous studies suggest that blood cultures in women with uncomplicated acute pyelonephritis (APN) are of limited value. Our objective was to assess the role of blood cultures in the management of complicated APN in women, and to examine the demographic and clinical characteristics, and the outcome as related to the bacteremic status of these patients.


METHODS
Data from medical records of 158 women hospitalized with complicated APN over a 2-year period were analyzed retrospectively. It included demographic, clinical and laboratory data, details of the empiric antimicrobial therapy, urine and blood culture results, complications and clinical outcome.


RESULTS
Out of 158 women with complicated APN, in 155 (98%) pathogens grew in the urine culture, and 33 (20.9%) of them had bacteremia. In the great majority of patients (98.7%), the blood cultures were sterile, or contained the same phenotypically profiled pathogen that was isolated from the urine. Only in two patients (1.3%), the blood cultures grew pathogens different from those found in the urine. The initial empiric antimicrobial therapy was not changed in any of the patients. No significant difference existed between the bacteremic and nonbacteremic patients in the demographic and clinical characteristics, the severity of disease or the outcome.


CONCLUSIONS
In the management of complicated APN, routine cultures of blood should be reevaluated.
Chen
Yael
Y
Infectious Diseases Unit, Ha'emek Medical Center, Afula 18101, Israel. chen_ya@clalit.org.il
Nitzan
Orna
O
Saliba
Walid
W
Chazan
Bibiana
B
Colodner
Raul
R
Raz
Raul
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D001431:Bacteriological Techniques; D001769:Blood / Q000382:microbiology*; D003470:Culture Media; D005260:Female; D006801:Humans; D008875:Middle Aged; D011704:Pyelonephritis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology; D014556:Urine / Q000382:microbiology
D003470:Culture Media