Doxorubicin-loaded calcium phosphate cement in the management of bone and soft tissue tumors.
Several materials have been used as drug delivery systems to maintain a high concentration of anticancer drugs at localized sites. The feasibility of using doxorubicin-loaded calcium phosphate cement (CPC) as a new material, which can release the drug as well as fill a postoperative bony defect, was investigated. The mechanical strength of cylinders of doxorubicin-loaded CPC was not lower than that of CPC alone. Culture medium incubated with doxorubicin-loaded CPC from 1 to 7 days suppressed the proliferation of RMT-1 E4 rat breast cancer cells. In rabbits with doxorubicin-loaded CPC in their femurs, histological examinations showed diffuse edematous changes in the medullary space, but neither fracture nor skin necrosis occurred. Doxorubicin-loaded CPC markedly inhibited the proliferation of sarcoma 180 cells in the mouse air-pouch model. These results indicate that doxorubicin-loaded CPC may be useful in the local treatment of malignant bone and soft tissue tumors.
Tani
Takayuki
T
Department of Orthopedic Surgery, Akita University School of Medicine, Akita, Japan.
Okada
Kyoji
K
Takahashi
Shu
S
Suzuki
Norio
N
Shimada
Yoichi
Y
Itoi
Eiji
E
D000818:Animals; D001696:Biomechanical Phenomena; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002130:Calcium Phosphates / Q000737:chemistry*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D011817:Rabbits; D051381:Rats; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology
D002130:Calcium Phosphates; D004317:Doxorubicin; C020243:calcium phosphate