Actin-dependent movement of bacterial pathogens.
Listeria, Rickettsia, Burkholderia, Shigella and Mycobacterium species subvert cellular actin dynamics to facilitate their movement within the host cytosol and to infect neighbouring cells while evading host immune surveillance and promoting their intracellular survival. 'Attaching and effacing' Escherichia coli do not enter host cells but attach intimately to the cell surface, inducing motile actin-rich pedestals, the function of which is currently unclear. The molecular basis of actin-based motility of these bacterial pathogens reveals novel insights about bacterial pathogenesis and fundamental host-cell pathways.
Stevens
Joanne M
JM
Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire, RG20 7NN, UK.
Galyov
Edouard E
EE
Stevens
Mark P
MP
D000199:Actins / Q000502:physiology*; D016957:Burkholderia pseudomallei / Q000502:physiology*; D008089:Listeria monocytogenes / Q000502:physiology*; D019910:Mycobacterium marinum / Q000502:physiology*; D020114:Rickettsia conorii / Q000502:physiology*; D012763:Shigella flexneri / Q000502:physiology*
D000199:Actins