title: Acetylcholinesterase effects on glutamate receptors.
abstract: We studied acetylcholinesterase (AChE) effects on glutamate receptors (GluR) in rat brain sections, synaptosomal membranes and cultured hippocampal neurones. A selective potentiation of AMPA receptors (AMPAR) binding in AMPAR-enriched layers undergoing synaptogenesis plus an increased surface expression of synaptic clusters of GluR1, GluR2, and SV2a was found. Thus, the AMPAR synaptic recruitment induced by AChE, could be a molecular mechanism underlying its non-classical synaptogenic actions.
authors.affiliation: Molecular Neuroscience Unit, Instituto Clemente Estable, Av. Italia 3318, Montevideo 11600, Uruguay.
authors.forename: Silvia
authors.initials: S
authors.lastname: Olivera Bravo
authors.forename: Jeremy
authors.initials: J
authors.lastname: Henley
authors.forename: Daniel
authors.initials: D
authors.lastname: Rodriguez-Ithurralde
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017470:Receptors, Glutamate / Q000378:metabolism*
chemical_list: D017470:Receptors, Glutamate; D000110:Acetylcholinesterase