title: Regulation of tumor angiogenesis by thrombospondin-1.
abstract: Angiogenesis plays a critical role in the growth and metastasis of tumors. Thrombospondin-1 (TSP-1) is a potent angiogenesis inhibitor, and down-regulation of TSP-1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types. Expression of TSP-1 is up-regulated by the tumor suppressor gene, p53, and down-regulated by oncogenes such as Myc and Ras. TSP-1 inhibits angiogenesis by inhibiting endothelial cell migration and proliferation and by inducing apoptosis. In addition, activation of transforming growth factor beta (TGF-beta) by TSP-1 plays a crucial role in the regulation of tumor progression. An understanding of the molecular basis of TSP-1-mediated inhibition of angiogenesis and tumor progression will aid in the development of novel therapeutics for the treatment of cancer.
authors.affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Ren
authors.forename: Karen O
authors.initials: KO
authors.lastname: Yee
authors.forename: Jack
authors.initials: J
authors.lastname: Lawler
authors.forename: Roya
authors.initials: R
authors.lastname: Khosravi-Far
mesh_terms: D020533:Angiogenesis Inhibitors / Q000502:physiology*; D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D019700:Thrombospondin 1 / Q000502:physiology*
chemical_list: D020533:Angiogenesis Inhibitors; D019700:Thrombospondin 1