title: Synthesis and pharmacological evaluation of novel quinoxalines as potential nonulcerogenic anti-inflammatory and analgesic agents.
abstract: Some new substituted quinoxaline and furo[2,3-b]quinoxaline derivatives have been synthesized and tested for their anti-inflammatory and analgesic activities and for their ulcerogenic potential. The pharmacological evaluation of selected synthesized compounds revealed that 5a was equipotent and compounds 3, 4b, 4e and 5b possessed strong anti-inflammatory activity in chronic inflammatory models compared with indometacin (CAS 53-86-1) as reference drug. In addition, compound 4a was the safest one and the others showed little ulcerogenic activity. All the tested compounds showed moderate analgesic activity compared to the reference drug.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy Girls, Al-Azhar University, Nasr City, Cairo Egypt. magda_f_ismail@yahoo.com
authors.forename: Magda M F
authors.initials: MM
authors.lastname: Ismail
authors.forename: Yousry A
authors.initials: YA
authors.lastname: Ammar
authors.forename: Mohamed K
authors.initials: MK
authors.lastname: Ibrahim
authors.forename: Heba S A
authors.initials: HS
authors.lastname: El-Zahaby
authors.forename: Sawsan S
authors.initials: SS
authors.lastname: Mahmoud
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D007202:Indicators and Reagents; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D011810:Quinoxalines / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced*
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D011810:Quinoxalines; D002351:Carrageenan