title: Eugenol depresses synaptic transmission but does not prevent the induction of long-term potentiation in the CA1 region of rat hippocampal slices.
abstract: Using field potential recording in the CA1 region of the rat hippocampal slices, the effects of eugenol on synaptic transmission and long-term potentiation (LTP) were investigated. Population spikes (PS) were recorded in the stratum pyramidal following stimulation of stratum fibers. To induce LTP, eight episodes of theta pattern primed-bursts (PBs) were delivered. Eugenol decreased the amplitude of PS in a concentration-dependent manner. The effect was fast and completely reversible. Eugenol had no effect on PBs-induced LTP of PS. It is concluded that while eugenol depresses synaptic transmission it does not affect the ability of CA1 synapses for tetanus-induced LTP and plasticity.
authors.affiliation: Department of Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Ardjmand
authors.forename: Y
authors.initials: Y
authors.lastname: Fathollahi
authors.forename: M
authors.initials: M
authors.lastname: Sayyah
authors.forename: M
authors.initials: M
authors.lastname: Kamalinejad
authors.forename: A
authors.initials: A
authors.lastname: Omrani
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D005054:Eugenol / Q000737:chemistry / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009822:Oils, Volatile / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012997:Solvents / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*; D027842:Syzygium / Q000737:chemistry; D013997:Time Factors
chemical_list: D009822:Oils, Volatile; D010938:Plant Oils; D012997:Solvents; D005054:Eugenol; D000241:Adenosine