[The effect of colchicine on the periodicity of the spontaneous and induced respiratory burst of granulocytes and monocytes during familial Mediterranean fever].
The influence of colchicine on the spontaneous and chemotaxis-, protein kinase C-, and phagocytosis-induced respiratory burst of neutrophils and monocytes in the peripheral blood of patients with familial Mediterranean fever (FMF) has been studied. The transient activation of neutrophils and monocytes on the level of a single cell has been monitored by means of flow cytofluorimetry. It is shown that colchicine blocks the induction of chemotaxis-, phagocytosis-, and proteinkinase C-dependent respiratory burst in vitro, as well as the increased pro-oxidant transient activation of neutrophils and monocytes of FMF patients, both in the period of remission and during the FMF attack. Colchicine stimulates the intensity of the spontaneous respiratory burst of neutrophils and monocytes in patients in the course of remission and during the FMF attack. At the same time, the drug effectively suppresses the periodicity of the multidirectional transient activation of the respiratory burst of effector cells during FMF.
Akopian
V P
VP
Avetisian
S A
SA
Davtian
T K
TK
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D010505:Familial Mediterranean Fever / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006074:Gout Suppressants / Q000494:pharmacology*; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D008262:Macrophage Activation / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D018375:Neutrophil Activation / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D011493:Protein Kinase C / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects*
D006074:Gout Suppressants; D011493:Protein Kinase C; D003078:Colchicine