title: Methadone as a chemical weapon: two fatal cases involving babies.
abstract: Methadone is largely used for the substitution management of opiate-dependent individuals but can also be easily found on the black market. The first cases involving repetitive sedation linked to the use of methadone and subsequent death of 2 babies are reported. At the autopsy, no particular morphologic changes were noted except for pulmonary and visceral congestion. There was no evidence of violence, and the pathologist in both cases found no needle marks. Toxicological analyses, as achieved by GC/MS, demonstrated both recent and repetitive methadone exposure. In case 1, a 14-month-old girl was found dead at home. Blood concentrations were 1071 and 148 ng/mL for methadone and EDDP, respectively. Hair (6 cm) tested positive at 1.91 and 0.82 ng/mg for methadone and EDDP, respectively. In case 2, a 5-month-old girl was taken to hospital in a pediatric unit for coma. Antemortem blood analysis demonstrated methadone exposure (142 ng/mL), and the baby was declared dead 12 days after admission. Hair analysis (5 cm) by segmentation was positive for methadone in the range 1.0 (root) to 21.3 ng/mg (end). The death of the babies was attributed to accidental asphyxia ina situation where methadone was considered as a chemical weapon. The mothers, who were the perpetrators in both cases, did not deny the use of methadone as a sedative drug.
authors.affiliation: X'pertise Consulting, Laboratoire ChemTox, Illkirch, France. pascal.kintz@wanadoo.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Kintz
authors.forename: Marion
authors.initials: M
authors.lastname: Villain
authors.forename: Véronique
authors.initials: V
authors.lastname: Dumestre-Toulet
authors.forename: Bernard
authors.initials: B
authors.lastname: Capolaghi
authors.forename: Vincent
authors.initials: V
authors.lastname: Cirimele
mesh_terms: D017809:Fatal Outcome; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007223:Infant; D008691:Methadone / Q000097:blood / Q000506:poisoning*; D009294:Narcotics / Q000097:blood / Q000506:poisoning*; D015813:Substance Abuse Detection / Q000379:methods
chemical_list: D009294:Narcotics; D008691:Methadone