Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization-embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures.
We performed a double-blinded retrospective cohort study to determine whether endometrial expression of mouse ascites Golgi mucin in a natural, unmedicated cycle predicts subsequent IVF-ET outcome among women with prior IVF-ET failure and poor pre-embryo quality. We found a statistically significant decrease in clinical pregnancy rate among women with abnormal mouse ascites Golgi expression, a test which was found to have high positive predictive value for failed IVF-ET.
Catalanotti
Jillian S
JS
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, Connecticut, USA.
Spandorfer
Stephen D
SD
Barmat
Larry I
LI
Rosenwaks
Zev
Z
McSweet
Juliette C
JC
Kliman
Harvey J
HJ
D000017:ABO Blood-Group System / Q000276:immunology / Q000378:metabolism*; D000328:Adult; D000906:Antibodies; D015415:Biomarkers; D001706:Biopsy; D015331:Cohort Studies; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D000939:Epitopes / Q000276:immunology / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009077:Mucins / Q000276:immunology / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D017211:Treatment Failure
D000017:ABO Blood-Group System; D000906:Antibodies; D015415:Biomarkers; D000939:Epitopes; D009077:Mucins