title: Cellulite: Is there a role for injectables?
abstract: BACKGROUND
  Cellulite describes the cutaneous dimpling of the thighs, buttocks, and hips that is seen predominately in women. Current evidence suggests that structural differences in fat architecture between the sexes account for its appearance. Mesotherapy, a method of delivering medication locally with the use of numerous cutaneous injections, has recently become a popular method to purportedly treat the condition.
  
  
  METHODS
  An overview of cellulite and adipocyte physiology, with a literature review and appraisal of compounds commonly used in mesotherapy.
  
  
  RESULTS
  Experimental studies using individual mesotherapy ingredients for other conditions suggest a number of mechanisms, including lipolysis, disrupting connective tissue and augmenting circulation, which may theoretically improve cellulite. Peer-reviewed studies have not evaluated whether these effects translate clinically.
  
  
  CONCLUSIONS
  Until further studies are performed, patients considering mesotherapy for cellulite must be aware that the substances currently being injected to treat this cosmetically disturbing, but medically benign, condition have not been thoroughly evaluated for safety or efficacy.
authors.affiliation: Department of Dermatology, University of Southern California Keck School of Medicine, Bennett Surgery Center, Santa Monica, CA 90404, USA. arotunda@hotmail.com
authors.forename: Adam M
authors.initials: AM
authors.lastname: Rotunda
authors.forename: Mathew M
authors.initials: MM
authors.lastname: Avram
authors.forename: Alison Sharpe
authors.initials: AS
authors.lastname: Avram
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000502:physiology*; D003357:Cosmetic Techniques; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D015552:Injections, Intralesional; D008066:Lipolysis / Q000502:physiology
chemical_list: D003879:Dermatologic Agents