title: Primary testicular and intraocular lymphomas: two case reports and a review of the literature.
abstract: Testicular lymphoma is a rare neoplasm of the testis that is most commonly seen in older patients. It metastasizes preferentially to extranodal sites, including the skin, central nervous system, Waldeyer ring, contralateral testis, and lung. Two case reports of patients with a history of testicular lymphoma who developed involvement of the vitreous and retina are presented. These are interesting cases as the testis, central nervous system, and eye are all immune privileged organs, which may account for occurrence of disease in these sites. Histopathologic examination of diagnostic vitrectomy specimens from both cases showed atypical lymphoid cells with immunoglobulin heavy chain (IgH) gene rearrangements, consistent with the diagnosis of intraocular B-cell lymphoma. The results of a literature review of all reports of ocular involvement with testicular lymphoma are discussed. Patients with testicular lymphoma are at risk for relapse, particularly in the central nervous system. Clinicians should be suspicious for intraocular lymphoma in patients with a history of testicular lymphoma who present with vitritis or retinal lesions.
authors.affiliation: National Eye Institute/NIH, Bldg. 10, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Wallace
authors.forename: Chandra R
authors.initials: CR
authors.lastname: Altemare
authors.forename: De Fen
authors.initials: DF
authors.lastname: Shen
authors.forename: Marc D
authors.initials: MD
authors.lastname: deSmet
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Buggage
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents