Recent trends in analytical procedures in forensic toxicology.
Forensic toxicology is a very demanding discipline,heavily dependent on good analytical techniques. That is why new trends appear continuously. In the past years. LC-MS has revolutionized target compound analysis and has become the trend, also in toxicology. In LC-MS screening analysis, things are less straightforward and several approaches exist. One promising approach based on accurate LC-MSTOF mass measurements and elemental formula based library searches is discussed. This way of screening has already proven its applicability but at the same time it became obvious that a single accurate mass measurement lacks some specificity when using large compound libraries. CE too is a reemerging approach. The increasingly polar and ionic molecules encountered make it a worthwhile addition to e.g. LC, as illustrated for the analysis of GHB. A third recent trend is the use of MALDI mass spectrometry for small molecules. It is promising for its ease-of-use and high throughput. Unfortunately, re-ports of disappointment but also accomplishment, e.g. the quantitative analysis of LSD as discussed here, alternate, and it remains to be seen whether MALDI really will establish itself. Indeed, not all new trends will prove themselves but the mere fact that many appear in the world of analytical toxicology nowadays is, in itself, encouraging for the future of (forensic) toxicology.
Van Bocxlaer
Jan F
JF
Laboratory of Medical Biochemistry and Clinical Analysis, Vakgroep Bio-analysis, Ghent University, Belgium. Jan.VanBocxlaer@UGent.be
D002623:Chemistry Techniques, Analytical / Q000379:methods* / Q000639:trends; D002853:Chromatography, Liquid / Q000379:methods / Q000639:trends; D019075:Electrophoresis, Capillary / Q000379:methods / Q000639:trends; D005554:Forensic Medicine / Q000379:methods* / Q000639:trends; D006801:Humans; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods / Q000639:trends; D014116:Toxicology / Q000379:methods* / Q000639:trends