[Alteration of insulin secretion in the elderly].
Aging per se is associated with reduced insulin secretion, which is an important contributing factor for pandemic of diabetes worldwide. Although underlying mechanism for it is not fully elucidated, a combination of reduced beta cell mass and impairment of insulin granule handing in the cell is most likely which may be due to age-related mitochondrial dysfunction and/or dysregulation of transcriptional factors. For effective prevention of diabetes in the elderly population, restoration of beta cell function is desired. Meanwhile, identification of insulin-deficient elderly patients with diabetes and an earlier institution of insulin therapy for them are recommended for improvement of treatment outcome.
Aizawa
Toru
T
Center for Health, Safety and Environmental Management, Shinshu University.
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000818:Animals; D003920:Diabetes Mellitus / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000502:physiology; D014157:Transcription Factors
D007328:Insulin; D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1