title: Effects of sarpogrelate hydrochloride in a patient with chronic graft-versus-host disease: a case report.
abstract: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogenic bone marrow transplantation. Even with aggressive treatment, cGVHD is associated with a significant degree of morbidity and mortality. cGVHD resembles autoimmune disorder, particularly systemic sclerosis (SSc). Sarpogrelate hydrochloride (SH) is an antagonist of the 5-hydroxytryptamine2A (5HT2A) receptor and has been reported to be effective in the treatment of systemic sclerosis (SSc) patients with Raynaud phenomenon. We used SH to treat a cGVHD patient, and we measured plasma PDGF and total TGF-beta levels. After SH treatment, his plasma PDGF and total TGF-beta levels decreased, and he noticed improvement in his skin pigmentation. In the present case, SH may have improved the skin lesion by inhibiting the synthesis of PDGF and TGF-beta.
authors.affiliation: Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan. tomoe11@nifty.com
authors.forename: Tomoe
authors.initials: T
authors.lastname: Hayashi
authors.forename: Eriko
authors.initials: E
authors.lastname: Morishita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ontachi
authors.forename: Masahide
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Hidesaku
authors.initials: H
authors.lastname: Asakura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D017479:Receptors, Platelet-Derived Growth Factor / Q000097:blood / Q000187:drug effects; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000097:blood / Q000187:drug effects
chemical_list: D012702:Serotonin Antagonists; D013386:Succinates; D016212:Transforming Growth Factor beta; C064294:sarpogrelate; D017479:Receptors, Platelet-Derived Growth Factor