New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases.
Aronoff
David M
DM
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Mich, USA.
Oates
John A
JA
Boutaud
Olivier
O
D000082:Acetaminophen / Q000378:metabolism / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D016877:Oxidants / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism* / Q000502:physiology
D018712:Analgesics, Non-Narcotic; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D016877:Oxidants; D010545:Peroxides; D000082:Acetaminophen; D011451:Prostaglandin-Endoperoxide Synthases