Dendrimers for pharmaceutical and biomedical applications.
Dendrimers are a unique class of synthetic macromolecules having a highly branched, three-dimensional, nanoscale architecture with very low polydispersity and high functionality. Structural advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. This review discusses several aspects of dendrimers, including preparation, dendrimer-drug coupling chemistry, structural models of dendrimer-based drug delivery systems, and physicochemical and toxicological properties.
Yang
Hu
H
School of Pharmacy, University of Wisconsin-Madison, WI 53705, USA.
Kao
Weiyuan John
WJ
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D050091:Dendrimers / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D008954:Models, Biological; D008970:Molecular Weight; D049329:Nanostructures
D050091:Dendrimers; D004337:Drug Carriers