AC-polarographic quantitation of tolmetin sodium.
Fundamental harmonic alternating current polarography has been described for the determination of tolmetin sodium and its capsules, (Tolectin-200 mg). The AC procedure was applied by superimposing 10 mV, rms, AC voltage on a DC ramp in the range -1200 to -1450 mV at a frequency of 50 Hz in acetate buffer of pH 5.0 containing 0.001% gelatin as a maxima suppressor. A three electrode assembly consisting of dropping mercury electrode (dme) and two Ag/AgCl/KCl (sat.) electrodes was employed. Mercury flow rate was 3 mg sec(-1) under a corrected head pressure of 80 cm. The electrode reaction was investigated by Kalousek K1 and K2 techniques which indicated the non-reversibility of the electrode process on the AC time scale. The percent result obtained by standard addition procedure was 101.4 +/- 2.0 for tolmetin sodium capsules.
Hagga
M E
ME
Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia.
Abounassif
M A
MA
Dawoud
A H
AH