Synthesis and screening of bicyclic carbohydrate-based compounds: a novel type of antivirals.
A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure-activity relationship for this new type of antivirals is discussed.
Van Hoof
Steven
S
Laboratory for Organic and Bioorganic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 (S.4), B-9000 Ghent, Belgium.
Ruttens
Bart
B
Hubrecht
Idzi
I
Smans
Gert
G
Blom
Petra
P
Sas
Benedikt
B
Van hemel
Johan
J
Vandenkerckhove
Jan
J
Van der Eycken
Johan
J
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D003587:Cytomegalovirus / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000196:embryology / Q000821:virology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D002241:Carbohydrates