title: Experience-dependent modification of mechanisms of long-term depression.
abstract: Mechanisms of long-term potentiation and depression (LTP and LTD) change considerably during development, but the importance of these changes and the factors that control them is not clear. We found that visual experience triggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recognition memory. Thus, changes in synaptic plasticity mechanisms were correlated with the changing physiological demands on the CNS.
authors.affiliation: Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Jo
authors.forename: Simon M
authors.initials: SM
authors.lastname: Ball
authors.forename: Heon
authors.initials: H
authors.lastname: Seok
authors.forename: Seog Bae
authors.initials: SB
authors.lastname: Oh
authors.forename: Peter V
authors.initials: PV
authors.lastname: Massey
authors.forename: Elek
authors.initials: E
authors.lastname: Molnar
authors.forename: Zafar I
authors.initials: ZI
authors.lastname: Bashir
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism; D008027:Light; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009924:Organ Culture Techniques; D051381:Rats; D017470:Receptors, Glutamate / Q000096:biosynthesis; D011976:Receptors, Muscarinic / Q000096:biosynthesis; D014785:Vision, Ocular / Q000502:physiology
chemical_list: D017470:Receptors, Glutamate; D011976:Receptors, Muscarinic