Paroxetine toxicity in a newborn after in utero exposure: clinical symptoms correlate with serum levels.
There are several case reports and case series that have examined the acute effects of selective serotonin reuptake inhibitors (SSRIs) on the newborn. There is considerable controversy whether the reported symptoms represent withdrawal from the SSRI or toxicity caused by the SSRI. A case of an infant who was exposed to paroxetine during pregnancy is presented. This case supports the notion of serotonin toxicity and is believed to be the first report that substantiates clinical symptoms with serum levels of the offending SSRI.
Knoppert
David C
DC
Department of Pharmacy, St Joseph's Hospital, London, ON, Canada. dave.knoppert@sjhc.london.on.ca
Nimkar
Ranjan
R
Principi
Tania
T
Yuen
Doris
D
D000328:Adult; D001942:Breast Feeding; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009357:Neonatal Abstinence Syndrome / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D017374:Paroxetine / Q000009:adverse effects* / Q000097:blood; D011247:Pregnancy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000097:blood
D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors