title: Choroidal dye filling velocity in patients with Vogt-Koyanagi-Harada disease.
abstract: OBJECTIVE
  To evaluate quantitative choroidal dye filling velocity in patients with Vogt-Koyanagi-Harada disease (VKH) before and after corticosteroid treatment using indocyanine green (ICG) angiography.
  
  
  METHODS
  ICG angiography was performed in seven VKH patients before and after systemic corticosteroid treatment. Choroidal dye curves were obtained by image analysis software and analyzed using an exponential model. The model's time constant (tau) was used to evaluate choroidal dye filling velocity.
  
  
  RESULTS
  Compared with controls, acute phase choroidal tau values in VKH patients were significantly longer, suggesting choroidal circulation disturbance. During the recovery phase, choroidal tau values were significantly shortened, suggesting choroidal circulatory disturbance improvement.
  
  
  CONCLUSIONS
  Choroidal dye filling velocity may be useful for VKH diagnosis and verification of corticosteroid treatment effectiveness.
authors.affiliation: Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mawatari
authors.forename: Akira
authors.initials: A
authors.lastname: Hirata
authors.forename: Mikiko
authors.initials: M
authors.lastname: Fukushima
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Tanihara
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use; D001775:Blood Circulation / Q000502:physiology*; D001783:Blood Flow Velocity; D002829:Choroid / Q000098:blood supply*; D004396:Coloring Agents; D004359:Drug Therapy, Combination; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D014607:Uveomeningoencephalitic Syndrome / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D004396:Coloring Agents; D005938:Glucocorticoids; D001623:Betamethasone; D011239:Prednisolone; D007208:Indocyanine Green