Use of simplified strategies to evaluate early treatment response in childhood acute lymphoblastic leukemia.
Early treatment response assessment has become an import prerequisite in the selection therapy in childhood ALL. In this study we compare classical diagnostic factors and the significance of three simplified strategies, WBC count at day 7 and a simplified PCR methodology to minimal residual disease detection on days 14 and 28, to evaluate early treatment response in 84 consecutive children with ALL. The use of these simplified methods for the evaluation of early response, proved to be a good predictor of an unfavorable course in children with ALL and could be used as a stratification criterion in treatment protocols, specially in low-budget countries.
Scrideli
Carlos Alberto
CA
Department of Pediatrics, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil. cascrideli@hcrp.fmrp.usp.br
de Paula Queiróz
Rosane
R
Bernardes
José Eduardo
JE
Defavery
Ricardo
R
Valera
Elvis Terci
ET
Tone
Luiz Gonzaga
LG
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D007958:Leukocyte Count; D008297:Male; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity; D016896:Treatment Outcome