title: Synthesis and biological activity of picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) analogues as potential antipsychotic agents.
abstract: A series of analogues related to picobenzide (CAS 51832-87-2) have been prepared and have been used as starting material to obtain new trisubstituted oxazole derivatives. Two compounds showed a promising pharmacological profile in screening tests of antipsychotic activity, since they affected apomorphine-induced hyperactivity without significant effects on stereotypies.
authors.affiliation: Departamento de Químicas, Facultad de Farmacia, Universidad San Pablo CEU, Boadilla del Monte, Madrid Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Gradillas
authors.forename: Berta
authors.initials: B
authors.lastname: López
authors.forename: Miguel F
authors.initials: MF
authors.lastname: Braña
authors.forename: Isabel
authors.initials: I
authors.lastname: Sancho
authors.forename: Carmen
authors.initials: C
authors.lastname: Pérez-García
authors.forename: Luis F
authors.initials: LF
authors.lastname: Alguacil
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001549:Benzamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006948:Hyperkinesis / Q000139:chemically induced / Q000517:prevention & control; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D014150:Antipsychotic Agents; D001549:Benzamides; D018491:Dopamine Agonists; D007202:Indicators and Reagents; C016938:picobenzide; D001058:Apomorphine