Interaction of botulinum toxin type A with local anesthetic agents: an experimental study with rabbits.
Injection of botulinum toxin is a painful procedure, limiting the number of patients treated. This study was designed to establish whether infiltration of local anesthetics plays a role in the effectiveness of botulinum toxin. For the study, 24 New Zealand white rabbits were divided into three groups. In all three groups, local anesthetics (prilocaine, lidocaine, lidocaine, and epinephrine) were injected into the right anterior auricular muscle before a 2.5-U injection of botox A. The contralateral anterior auricular muscle of all the rabbits was injected with the same dose of the toxin to serve as a control. Photographic documentation was recorded; electromyographic study was performed; and results were statistically analyzed. The results show that local anesthetics do not play a role in the efficacy of botulinum toxin. Thus, the use of infiltrative local anesthetics before botulinum toxin injection is a safe method for achieving a less painful procedure for the patient.
Görgü
Metin
M
Ataturk Training and Research Hospital, Izmir, Turkey.
Silistreli
Ozlem Karataş
OK
Karantinaci
Burçe
B
Ayhan
Meltem
M
Ozdemirkiran
Tolga
T
Celebisoy
Mehmet
M
D000779:Anesthetics, Local / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism*; D004576:Electromyography; D007279:Injections, Subcutaneous; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D011343:Procaine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D013748:Tetracaine / Q000494:pharmacology / Q000627:therapeutic use
D000779:Anesthetics, Local; D009465:Neuromuscular Agents; D013748:Tetracaine; D011343:Procaine; C004616:chloroprocaine; D019274:Botulinum Toxins, Type A