Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection.
Drug hypersensitivity syndrome (DHS) is an idiosyncratic and life-threatening adverse drug reaction characterized by skin rash and multiorgan involvement. In rare cases, fulminant type1 diabetes mellitus (DM) may develop after DHS. Among proposed pathogenesis, human herpesvirus 6 (HHV-6) infections may play a role in the development of DHS. We report a case of DHS associated with HHV-6 reactivation, complicated with a rare sequela of irreversible fulminant type 1 DM. No diabetes-related autoantibodies were detected. Early detection and intervention for this serious complication should be given in patients with DHS. Fulminant type1 DM associated with DHS is reviewed. The role of HHV-6 in DHS associated with fulminant type 1 DM is also discussed.
Chiou
Chien-Chun
CC
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chung
Wen-Hung
WH
Hung
Shuen-Iu
SI
Yang
Li-Cheng
LC
Hong
Hong-Shang
HS
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D016883:Diabetic Ketoacidosis / Q000209:etiology; D003875:Drug Eruptions / Q000150:complications* / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D008297:Male; D012008:Recurrence; D019349:Roseolovirus Infections / Q000150:complications*; D014775:Virus Activation / Q000187:drug effects*