Gene-for-gene-mediated recognition of nuclear-targeted AvrBs3-like bacterial effector proteins.
Plant disease resistance (R) genes mediate specific recognition of pathogens via perception of cognate avirulence (avr) gene products. The numerous highly similar AvrBs3-like proteins from the bacterial genus Xanthomonas provide together with their corresponding R proteins a unique biological resource to dissect the molecular basis of recognition specificity. A central question in this context is if R proteins that mediate recognition of structurally similar Avr proteins are themselves functionally similar or rather dissimilar. The recent isolation of rice xa5, rice Xa27 and tomato Bs4, R genes that collectively mediate recognition of avrBs3-like genes, provides a first clue to the molecular mechanisms that plants employ to detect AvrBs3-like proteins. Their initial characterization suggests that these R proteins are structurally and functionally surprisingly diverge. This review summarizes the current knowledge on R-protein-mediated recognition of AvrBs3-like proteins and provides working models on how recognition is achieved at the molecular level.
Schornack
Sebastian
S
Institut für Genetik, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Saale), Germany.
Meyer
Annett
A
Römer
Patrick
P
Jordan
Tina
T
Lahaye
Thomas
T
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000235:genetics; D018506:Gene Expression Regulation, Plant; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000382:microbiology*; D011995:Recombination, Genetic; D020449:Repetitive Sequences, Amino Acid; D014774:Virulence; D014974:Xanthomonas / Q000235:genetics / Q000472:pathogenicity*
D001426:Bacterial Proteins; D010940:Plant Proteins