[Botulinum toxin in spasm treatment in adults].
Botulinum toxin (BTX) is a powerful neurotoxin which blocks cholinergic transmission at the neuromuscular junction. Judiciously applied it can reduce local muscle over activity while maintaining the strength in other muscles. For focal or segmental dystony it has been a medication of choice. Refined botullinum toxin A being applied in affected groups of muscles weaker power of contraction. Basic mechanism which weaker contraction remands the same. Controlled trials have provided evidence of the effectiveness of BTX both in reducing spasticity itself and in achieving functional gain. The guidance given here to clinicians involved in the management of spasticity covers the types of patient suitable for treatment using BTX, the appropriate dosage, and the necessary follow-up procedures and documentation.
Alajbegović
Azra
A
Neuroloska klinika Klinickog centra Univerziteta u Sarajevu, Bosna i Hercegovina.
Mehmedika-Suljić
Enra
E
Alajbegović
Salem
S
D000328:Adult; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use*; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D006801:Humans; D009128:Muscle Spasticity / Q000188:drug therapy*
D018726:Anti-Dyskinesia Agents; D019274:Botulinum Toxins, Type A