Considerations in the evaluation of haemophilia patients for short-term prophylactic therapy: a paediatric and adult case study.
The long-term prophylactic administration of clotting factor concentrate in patients with haemophilia reduces bleeding events, slows joint deterioration, and improves quality of life. Prophylaxis can also be effective when used short-term to prevent or reduce bleeding associated with trauma, surgery, and athletic activities. While clinical trials are needed to establish the optimal length of prophylaxis following injury, several weeks and possibly months of treatment may be needed. Discontinuing therapy prematurely can result in rebleeding in the injured area.
Luchtman-Jones
L
L
Washington University, St Louis, MO, USA.
Valentino
L A
LA
Manno
C
C
D000208:Acute Disease; D000328:Adult; D006259:Craniocerebral Trauma / Q000150:complications; D005169:Factor VIII / Q000627:therapeutic use*; D006406:Hematoma / Q000209:etiology / Q000517:prevention & control*; D020199:Hematoma, Subdural, Acute / Q000209:etiology / Q000517:prevention & control; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007869:Leg Injuries / Q000150:complications; D008297:Male; D009135:Muscular Diseases / Q000517:prevention & control; D013848:Thigh; D016896:Treatment Outcome
C078147:F8 protein, human; D005169:Factor VIII