title: Mid-trimester fetal-placental velocimetry response to nifedipine may predict early the onset of pre-eclampsia.
abstract: The effect of nifedipine on fetal-placental blood flow at 22-24 weeks in patients with pregnancy-induced hypertension (PIH) was evaluated. Twenty patients with PIH were submitted to the Doppler evaluation of fetal-placental perfusion at 22-24 weeks. The systo-diastolic (SID) ratio and the pulsatility index (PI) of uterine, umbilical and middle cerebral arteries and systemic blood pressure were recorded before and 7 days after nifedipine administration (10 mg/ per os 3 times/day until delivery). Statistical analysis was performed with paired and unpaired t-test and the two-tailed Fisher exact test. Nifedipine significantly (p < 0.05) decreased the mean systolic pressure in all patients (from 146 to 135 mmHg): 8 patients developed pre-eclampsia (PE) complicated by fetal growth restriction (FGR) (PE group), whilst the remaining were only affected by PIH (PIH group). The gestational age at delivery, neonatal birthweight and 1- and 5-min Apgar scores were significantly (p < 0.001) lower in PE than in PIH women. Nifedipine treatment significantly changed the PI and S/D ratio (mean +/- SEM) of the uterine (PI from 0.66 +/- 0.01 to 0.51 + 0.01; SID ratio: from 2.00 +/- 0.09 to 1.79 + 0.05) and umbilical (PI: from 1.55 +/- 0.04 to 1.40 +/- 0.02; S/D ratio: from 2.45 +/- 0.09 to 2.31+/- 0.09) arteries and the middle cerebral PI (from 1.45 +/- 0.03 to 1.61 +/- 0.01) artery only in PIH, but not in PE patients. Fetal-placental blood flow changes after nifedipine may early identify patients at risk of PE.
authors.affiliation: Department of Gynaecology, Obstetrics and Reproduction, Second University of Naples, Naples, Italy. luigi.cobellis@unina2.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Cobellis
authors.forename: Antonio
authors.initials: A
authors.lastname: De Luca
authors.forename: Emilia
authors.initials: E
authors.lastname: Pecori
authors.forename: Annunziata
authors.initials: A
authors.lastname: Mastrogiacomo
authors.forename: Laura
authors.initials: L
authors.lastname: Di Pietto
authors.forename: Iolanda
authors.initials: I
authors.lastname: Iannella
authors.forename: Felice
authors.initials: F
authors.lastname: Fornaro
authors.forename: Cono
authors.initials: C
authors.lastname: Scaffa
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cobellis
authors.forename: Nicola
authors.initials: N
authors.lastname: Colacurci
mesh_terms: D005260:Female; D005333:Fetus / Q000098:blood supply / Q000187:drug effects*; D006801:Humans; D009543:Nifedipine / Q000008:administration & dosage*; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second
chemical_list: D009543:Nifedipine