Antibody responses to meningococcal (groups A, C, Y and W135) polysaccharide diphtheria toxoid conjugate vaccine in children who previously received meningococcal C conjugate vaccine.
A randomised, modified, double-blind trial was conducted in children 2 to < 5 years of age to evaluate immunogenicity and reactogenicity of a meningococcal (serogroups A, C, Y, W135) diphtheria toxoid conjugate vaccine (MCV-4) in healthy children previously vaccinated with a monovalent meningococcal C conjugate vaccine. Participants received one dose of either MCV-4 or Haemophilus influenzae type b vaccine (Hib vaccine, control group). Serum bactericidal antibodies (SBA) were determined in sera obtained before and approximately 28 days following vaccination. MCV-4 was highly immunogenic for serogroups A, C, Y and W135, the response to serogroup C being consistent with a booster response in participants primed with monovalent C conjugate vaccine. No major between-group differences in solicited local and systemic reactions or adverse events (AEs).
El Bashir
Haitham
H
Research Centre for Child Health, St. Bartholomew's and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. haitham.elbashir@haringey.nhs.uk
Heath
Paul T
PT
Papa
Thomas
T
Ruggeberg
Jens U
JU
Johnson
Nik
N
Sinha
Ruchi
R
Balfour
Gail
G
Booy
Robert
R
D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000276:immunology; D004311:Double-Blind Method; D006801:Humans; D007156:Immunologic Memory; D008585:Meningitis, Meningococcal / Q000276:immunology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D009345:Neisseria meningitidis / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology; D018074:Vaccines, Conjugate / Q000009:adverse effects / Q000276:immunology
D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate; C410218:serogroup C meningococcal conjugate vaccine