Effect of viscosity and buffer salts on the stability of sulphacetamide solutions.
A study of identification and rate determination of degradation products of sulphacetamide in aqueous solutions during UV irradiation and thermolysis at 70 degrees , 80 degrees and 90 degrees C is made. The effect of viscosity and buffer salts in presence of antioxidants on the rate of hydrolysis is investigated. An increase in the viscosity of solution results in a decrease in the rate of hydrolysis. Similar viscosity effect has been observed on the photolysis of sulphacetamide solutions. No significant salt effect on the rate of hydrolysis of sulphacetamide in citrate and phosphate buffers (pH7.4) has been noticed. The thermodynamic parameter, E(a), deltaH, deltaS for the reaction have been determined.
Ahmad
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Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan.