title: Association of serum reactive oxygen metabolite levels with different histopathological types of lung cancer.
abstract: BACKGROUND
  Oxygen is required for respiration and the energetic processes that enable aerobic life. Costs associated with oxygen use are free radical and reactive oxygen metabolite (ROM) formations, which create oxidative stress and contribute to various processes including aging, degenerative diseases and cancer. Additionally, they may have a role in the pathogenesis of lung cancer with different histopathological types.
  
  
  OBJECTIVE
  In this study, we aimed to investigate the degree of oxidative stress in different types of carcinoma such as small cell carcinoma and non-small cell carcinoma, including epidermoid carcinoma and adenocarcinoma, and to find out whether the degree of oxidative stress shows any difference among them and whether it can be used as an index for their differential diagnosis.
  
  
  METHODS
  Thirty-eight patients with lung cancer and 26 healthy persons were included in the study. Of the patients with lung cancer, 14 had epidermoid carcinoma, 12 adenocarcinoma and 12 small cell carcinoma. Serum ROM levels were detected by using an available commercial kit according to the manufacturer's instructions.
  
  
  RESULTS
  The ROM levels were significantly lower in the controls than in the patients (p<0.001). Although all subtypes had significantly high ROM levels compared with the controls, the highest significance was found in the small cell carcinoma (p<0.001), and then in the adenocarcinoma and epidermoid carcinoma (p<0.01 and p<0.01, respectively).
  
  
  CONCLUSIONS
  In the light of these data, it might be possible to conclude that the serum ROM levels increase in patients with different types of lung cancers and may be an index parameter for lung cancer. It could be thought that this increase, particularly in small cell carcinoma, may contribute to its poor progression.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Harran University, Sanliurfa, Turkey. mgencer@harran.edu.tr
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gencer
authors.forename: Erkan
authors.initials: E
authors.lastname: Ceylan
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Kürsat
authors.initials: K
authors.lastname: Uzun
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000145:classification / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000145:classification / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000097:blood*; D012016:Reference Values; D012907:Smoking / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D017382:Reactive Oxygen Species