title: A novel convenient synthesis of benzoquinazolines.
abstract: [reaction: see text] A novel synthetic pathway to benzoquinazolines from naphthylamines is reported. Benzoquinazoline nucleus was cyclized in good yield from N-protected naphthylamines using hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH. This method is efficient and convenient with respect to previously reported synthetic pathways.
authors.affiliation: Department of Pharmaceutical Sciences, University of Padova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Marzaro
authors.forename: Adriana
authors.initials: A
authors.lastname: Chilin
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pastorini
authors.forename: Adriano
authors.initials: A
authors.lastname: Guiotto
mesh_terms: D015081:2-Naphthylamine / Q000031:analogs & derivatives* / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D007202:Indicators and Reagents; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis*
chemical_list: D001555:Benzene Derivatives; D007202:Indicators and Reagents; D011799:Quinazolines; D015081:2-Naphthylamine