title: Second and third malignant solid tumor in a girl with ovarian Sertoli-Leydig tumor.
abstract: We report a Sertoli-Leydig cell (SLC) tumor of the right ovary in a 10-year-old girl, which was dealt with surgical removal. Three months after resection, she presented with a new episode of acute abdomen because of an abdominal mass, which histologically was compatible with an undifferentiated embryonal rhabdomyosarcoma. Chemotherapy, according to SIOP-??? 89 protocol, was administered additionally to radiotherapy (3,960 cGy). Three years after completing treatment, the patient developed a painful swelling at her left upper arm. The diagnosis was Ewing sarcoma of the humerus, which was confirmed by identification of the typical 11; 22 translocation on cytogenetic and molecular analysis of the tumor tissue. The patient died 14 months from Ewing diagnosis due to progressive disease.
authors.affiliation: Department of Pediatric Hematology/Oncology, "Aghia Sophia" Children's Hospital, Athens, Greece. pepisofou@hotmail.com
authors.forename: John P
authors.initials: JP
authors.lastname: Panagiotou
authors.forename: Sophia
authors.initials: S
authors.lastname: Polychronopoulou
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Sofou
authors.forename: Catherine
authors.initials: C
authors.lastname: Vanvliet-Constantinidou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Papandreou
authors.forename: Stavros
authors.initials: S
authors.lastname: Haidas
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D018310:Sertoli-Leydig Cell Tumor / Q000473:pathology*; D014178:Translocation, Genetic