Fiber molecular model of atelocollagen-small interfering RNA (siRNA) complex.
Previously we represented molecular model of collagen triple helix-DNA double helix complex [G.M. Mrevlishvili, D.V. Svintradze, Int. J. Macromol. 36 (2005) 324-326; G.M. Mrevlishvili, D.V. Svintradze, Int. J. Macromol. 35 (2005) 243-245]. We also proved that during the complex formation hydration of triple helix destroys and forms new water bridges maintaining the complex nano-structure. In this paper we demonstrate that small interfering RNA binds to atelocollagen directly to form siRNA-atelocollagen fiber complex.
Svintradze
David V
DV
Department of Physics, Tbilisi State University, Chavchavadze av. 3, Tbilisi 0128, Georgia. dsvintra@yahoo.com
Mrevlishvili
George M
GM
D000818:Animals; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D017434:Protein Structure, Tertiary; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000378:metabolism
D034741:RNA, Small Interfering; C059821:atelocollagen; D003094:Collagen