title: Effect of curcumin on the expression of LDL receptor in mouse macrophages.
abstract: To investigate the molecular mechanisms of lipid-lowering drug, Rhizoma Curcumae Longae, we treated the mouse macrophages with curcumin, which was purified from the ethanol extraction of Rhizoma Curcumae Longae. The LDL receptors expressed in the macrophages were determined by ELISA, FLISA and assay of LDL uptake. Here for the first time, we found that curcumin obviously up-regulated the expression of LDL receptor in mouse macrophages, and the dose-effect relationship was demonstrated.
authors.affiliation: Institute of Molecular Medicine, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053, China. taijispear@126.com
authors.forename: Chunlei
authors.initials: C
authors.lastname: Fan
authors.forename: Xingde
authors.initials: X
authors.lastname: Wo
authors.forename: Ying
authors.initials: Y
authors.lastname: Qian
authors.forename: Jin
authors.initials: J
authors.lastname: Yin
authors.forename: Liping
authors.initials: L
authors.lastname: Gao
mesh_terms: D000818:Animals; D002460:Cell Line; D003474:Curcumin / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D011973:Receptors, LDL / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D011973:Receptors, LDL; D003474:Curcumin