title: Diagnosis and management of heterokaryotypic monochorionic twins.
abstract: The diagnosis, management, and outcome of six consecutive heterokaryotypic monochorionic twins were evaluated. All suspected cases, based on discordant ultrasound findings, underwent amniocentesis of both sacs. Two cases also had chorionic villous sampling (CVS). Dual amniocentesis was superior to CVS in diagnosing heterokaryotypic monochorionic twins. In four cases, the X-chromosome was involved and autosomal aneuploidy was noted in the others. In five cases, the anomalous twin was selectively reduced by cord coagulation. All pregnancies ended with a phenotypically normal liveborn and all children are developing normally at 1-7 years of age.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium.
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Lewi
authors.forename: Isaac
authors.initials: I
authors.lastname: Blickstein
authors.forename: Dominique
authors.initials: D
authors.lastname: Van Schoubroeck
authors.forename: Karl-Philipp
authors.initials: KP
authors.lastname: Gloning
authors.forename: Martine
authors.initials: M
authors.lastname: Casteels
authors.forename: Helen
authors.initials: H
authors.lastname: Brandenburg
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Fryns
authors.forename: Jan
authors.initials: J
authors.lastname: Deprest
mesh_terms: D000328:Adult; D000649:Amniocentesis; D002648:Child; D002675:Child, Preschool; D004200:Diseases in Twins / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal / Q000379:methods*; D014430:Twins, Monozygotic