Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonate.
In neonates, herpes simplex virus (HSV) infections can lead to severe diseases associated with high mortality. We report a 6-day-old girl who developed clinical signs of fulminant hepatic failure accompanied by infectious-toxic shock and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The diagnosis was performed postmortem by demonstration of HSV-1 DNA in liver tissue as well as by retrospective detection of HSV-specific antibodies.
Meerbach
Astrid
A
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University of Jena, Hans-Knöll-Street 2, 07745 Jena, Germany. astrid.meerbach@med.uni-jena.de
Sauerbrei
Andreas
A
Meerbach
Werner
W
Bittrich
Hans-Jörg
HJ
Wutzler
Peter
P
D000914:Antibodies, Viral / Q000097:blood; D004211:Disseminated Intravascular Coagulation; D017809:Fatal Outcome; D005260:Female; D006525:Hepatitis, Viral, Human / Q000401:mortality / Q000473:pathology / Q000821:virology*; D006561:Herpes Simplex / Q000150:complications* / Q000401:mortality / Q000821:virology; D018259:Herpesvirus 1, Human; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000473:pathology / Q000821:virology; D017114:Liver Failure, Acute; D009336:Necrosis
D000914:Antibodies, Viral