title: Postinfectious gastroparesis related to autonomic failure: a case report.
abstract: OBJECTIVE
  Severe dysautonomia may be secondary to viral infections, resulting in impaired autoimmune, cardiovascular, urinary and digestive dysfunction. Herein, we present a case of a 31-year-old white female patient who had severe gastroparesis related to autonomic failure following an episode of acute gastroenteritis. This seems to be the first report providing thorough assessment of the enteric and autonomic nervous system by analysis of full-thickness small intestinal biopsies, cardiovagal testing and autopsy.
  This patient affected by a severe gastroparesis was treated with antiemetics, prokinetics, analgesics and gastric electrical stimulation to control symptoms. Nutritional support was made using jejunal feeding tube and, in the final stage of disease, with total parenteral nutrition. Autonomic studies revealed minimal heart rate variability and a disordered Valsalva manoeuvre although the enteric nervous system and the smooth muscle layer showed a normal appearance. Hospital courses were complicated by episodes of bacteraemia and fungemia. Serum antiphospholipid antibodies were noted but despite anticoagulation, she developed a pulmonary embolism and shortly thereafter the patient died. Autopsy revealed acute haemorrhagic Candida pneumonia with left main pulmonary artery thrombus. Sympathetic chain analysis revealed decreased myelinated axons with vacuolar degeneration and patchy inflammation consistent with Guillain-Barre syndrome. The evaluation of the enteric nervous system in the stomach and small bowel revealed no evidence of enteric neuropathy or myopathy.
  
  
  CONCLUSIONS
  A Guillain-Barre-like disease with gastroparesis following acute gastroenteritis is supported by physiological and autonomic studies with histological findings.
authors.affiliation: Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lobrano
authors.forename: K
authors.initials: K
authors.lastname: Blanchard
authors.forename: T L
authors.initials: TL
authors.lastname: Abell
authors.forename: A
authors.initials: A
authors.lastname: Minocha
authors.forename: W
authors.initials: W
authors.lastname: Boone
authors.forename: J
authors.initials: J
authors.lastname: Wyatt-Ashmead
authors.forename: J
authors.initials: J
authors.lastname: Fratkin
authors.forename: C
authors.initials: C
authors.lastname: Subramony
authors.forename: A
authors.initials: A
authors.lastname: Wee
authors.forename: G
authors.initials: G
authors.lastname: Di Nardo
authors.forename: G
authors.initials: G
authors.lastname: Barbara
authors.forename: V
authors.initials: V
authors.lastname: Stanghellini
authors.forename: R
authors.initials: R
authors.lastname: De Giorgio
mesh_terms: D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D002177:Candidiasis / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D005759:Gastroenteritis / Q000150:complications*; D018589:Gastroparesis / Q000209:etiology*; D020275:Guillain-Barre Syndrome / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D011014:Pneumonia / Q000382:microbiology; D013270:Stomach / Q000294:innervation; D014777:Virus Diseases / Q000150:complications