title: Rapid synthesis of triazole-modified resveratrol analogues via click chemistry.
abstract: Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency.
authors.affiliation: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale A. Avogadro, 28100 Novara, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pagliai
authors.forename: Tracey
authors.initials: T
authors.lastname: Pirali
authors.forename: Erika
authors.initials: E
authors.lastname: Del Grosso
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Brisco
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Tron
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sorba
authors.forename: Armando A
authors.initials: AA
authors.lastname: Genazzani
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D000077185:Resveratrol; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes; D014230:Triazoles; D000077185:Resveratrol