title: Effect of photodynamic therapy on tumor angiogenesis and metastasis in mice bearing Lewis lung carcinoma.
abstract: OBJECTIVE
  To investigate the influence of photodynamic therapy (PDT) on the tumor angiogenesis and metastasis.
  
  
  METHODS
  The effect of PDT with a photosensitizer 5-aminolaevulinic acid (ALA) on tumor metastasis and angiogenesis was studied on the model of subcutaneously implanted Lewis lung carcinoma (3LL) in C57Bl/6 mice. VEGF level in blood serum of animals was evaluated by ELISA.
  
  
  RESULTS
  It has been shown that application of ALA-PDT resulted in the lowered rate of metastatic spreading and decreased VEGF level in blood serum of 3LL-bearing mice, and morphologic alterations of vascular system in tumor tissue.
  
  
  CONCLUSIONS
  The antitumor action of PDT using ALA as a photosensitizer is caused partly by antimetastatic and photodamaging effect mediated by vascularization disturbances in tumor tissue.
authors.affiliation: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine.
authors.forename: I O
authors.initials: IO
authors.lastname: Lisnjak
authors.forename: V V
authors.initials: VV
authors.lastname: Kutsenok
authors.forename: L Z
authors.initials: LZ
authors.lastname: Polyschuk
authors.forename: O B
authors.initials: OB
authors.lastname: Gorobets
authors.forename: N F
authors.initials: NF
authors.lastname: Gamaleia
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use; D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000098:blood supply / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010789:Phototherapy; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D017319:Photosensitizing Agents; D042461:Vascular Endothelial Growth Factor A; D000622:Aminolevulinic Acid