Clinical toxicology: clinical science to public health.
1. The aims of the present paper are to: (i) review progress in clinical toxicology over the past 40 years and to place it in the context of modern health care by describing its development; and (ii) illustrate the use of clinical toxicology data from Scotland, in particular, as a tool for informing clinical care and public health policy with respect to drugs. 2. A historical literature review was conducted with amalgamation and comparison of a series of published and unpublished clinical toxicology datasets from NPIS Edinburgh and other sources. 3. Clinical databases within poisons treatment centres offer an important method of collecting data on the clinical effects of drugs in overdose. These data can be used to increase knowledge on drug toxicity mechanisms that inform licensing decisions, contribute to evidence-based care and clinical management. Combination of this material with national morbidity datasets provides another valuable approach that can inform public health prevention strategies. 4. In conclusion, clinical toxicology datasets offer clinical pharmacologists a new study area. Clinical toxicology treatment units and poisons information services offer an important health resource.
Bateman
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NPIS Edinburgh, Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK. Nick.bateman@luht.scot.nhs.uk
D000701:Analgesics, Opioid / Q000506:poisoning; D014150:Antipsychotic Agents / Q000506:poisoning; D001145:Arrhythmias, Cardiac / Q000209:etiology; D011431:Dextropropoxyphene / Q000506:poisoning; D004346:Drug Information Services; D004562:Electrocardiography / Q000187:drug effects; D019317:Evidence-Based Medicine; D006801:Humans; D010601:Pharmacology, Clinical / Q000379:methods / Q000639:trends*; D011039:Poison Control Centers; D011634:Public Health; D012606:Scotland; D013881:Thioridazine / Q000506:poisoning; D014116:Toxicology / Q000639:trends*
D000701:Analgesics, Opioid; D014150:Antipsychotic Agents; D013881:Thioridazine; D011431:Dextropropoxyphene