title: No mutation was detected in the LMNA gene among sporadic Charcot-Marie-Tooth patients.
abstract: OBJECTIVE
  To intensively investigate sporadic CMT patients, we have analyzed the LMNA gene in this study in a series of 32 unrelated CMT patients.
  
  
  METHODS
  Twelve exons of the LMNA gene were amplified from genetic DNA. PCR products of each exon were analyzed by single strand conformational polymorphism (SSCP).
  
  
  RESULTS
  No abnormal SSCP pattern, suggesting no mutation in our CMT patients, was detected.
  
  
  CONCLUSIONS
  The CMT diseases resulted from the mutations of LMNA gene were rare.
authors.affiliation: Peking University Center of Medical Genetics, Beijing 100083, China.
authors.forename: Shu-juan
authors.initials: SJ
authors.lastname: Song
authors.forename: Yuan-zhi
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Biao
authors.initials: B
authors.lastname: Chen
authors.forename: Man-jie
authors.initials: MJ
authors.lastname: Wang
authors.forename: Yue-ying
authors.initials: YY
authors.lastname: Wang
authors.forename: Yuan-jin
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Nanbert
authors.initials: N
authors.lastname: Zhong
mesh_terms: D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis / Q000235:genetics*; D005091:Exons; D006801:Humans; D034904:Lamin Type A / Q000235:genetics*; D009154:Mutation; D018807:Polymorphism, Single-Stranded Conformational
chemical_list: C494847:LMNA protein, human; D034904:Lamin Type A