Hormonology: a genomic perspective on hormonal research.
Recent advances in comparative genomics allow a new paradigm for hormonal research. At the centennial of the first use of the term hormone by Ernest Starling, we reflected on the changing approaches in elucidating hormonal signaling mechanisms and highlighted the inadequacy of the term endocrinology, implying remote activation, to describe the diverse modes of hormone actions. Several examples were presented to underscore the power of comparative genomics in the identification of new polypeptide hormones, receptors, and signaling pathways. We propose the use of the term hormonology to more accurately reflect the expanding boundaries of the discipline.
Hsueh
A J W
AJ
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5317, USA. aaron.hsueh@stanford.edu
Bouchard
P
P
Ben-Shlomo
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D055430:Bone Morphogenetic Protein 15; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology; D002450:Cell Communication / Q000235:genetics / Q000502:physiology; D015894:Genome, Human; D023281:Genomics; D055429:Growth Differentiation Factor 9; D006728:Hormones / Q000097:blood / Q000235:genetics / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D008024:Ligands; D036361:Peptide Hormones / Q000235:genetics / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology
C525901:BMP15 protein, human; C525718:BMP2 protein, human; D055430:Bone Morphogenetic Protein 15; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; C525897:GDF9 protein, human; D055429:Growth Differentiation Factor 9; D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D036361:Peptide Hormones; D043562:Receptors, G-Protein-Coupled; D016212:Transforming Growth Factor beta