title: A randomised double-blind controlled study evaluating the hypothermic effect of 150 microg morphine during spinal anaesthesia for Caesarean section.
abstract: We studied the hypothermic effect of adding 150 microg morphine during spinal anaesthesia in 60 parturients scheduled for elective caesarean section. All the parturients received intrathecal injection of a solution containing 150 mug morphine or normal saline in addition to 10-12 mg hyperbaric bupivacaine 0.5%. In both groups, a significant decrease in body temperature was noted. There was no difference in the area under the curve for temperature against time for the two groups; however, the maximum decrease in temperature from baseline was significantly larger after morphine than after saline injection (mean (SD) 1.11 (0.61) degrees C vs 0.76 (0.39) degrees C, respectively; p = 0.01) and the time to nadir temperature was significantly longer (59.5 (17.6) min vs 50.4 (15.9) min, respectively; p = 0.047). The lowest temperature observed in the morphine group was 34.3 degrees C. We conclude that intrathecal injection of 150 microg morphine intensified the intra-operative hypothermic effect of bupivacaine spinal anaesthesia for caesarean section.
authors.affiliation: Department of Anaesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: C-K
authors.initials: CK
authors.lastname: Hui
authors.forename: C-H
authors.initials: CH
authors.lastname: Huang
authors.forename: C-J
authors.initials: CJ
authors.lastname: Lin
authors.forename: H-P
authors.initials: HP
authors.lastname: Lau
authors.forename: W-H
authors.initials: WH
authors.lastname: Chan
authors.forename: H-M
authors.initials: HM
authors.lastname: Yeh
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000009:adverse effects* / Q000379:methods; D000775:Anesthesia, Spinal / Q000009:adverse effects* / Q000379:methods; D000779:Anesthetics, Local / Q000009:adverse effects; D019540:Area Under Curve; D001831:Body Temperature / Q000187:drug effects; D002045:Bupivacaine / Q000009:adverse effects; D002585:Cesarean Section; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000139:chemically induced; D009020:Morphine / Q000009:adverse effects*; D011247:Pregnancy
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009020:Morphine; D002045:Bupivacaine