title: Post-varicella intracranial haemorrhage in a child.
abstract: We report a case of a 7-month-old male with primary intracranial haemorrhage 2 months after infection with varicella zoster virus (VZV). His initial clinical course was complicated by seizures and right hemiparesis; when last seen at 22 months the only positive finding was of left hand preference. Although the literature has recently established the association of arterial ischaemic stroke and VZV infection, primary intracranial haemorrhage has been reported only in one case. The child reported here had anterior interhemispheric haemorrhage due to a focal arteritis of the left anterior cerebral artery. The vascular abnormality was transient and had radiological features compatible with either a focal arteritis or vasospasm as a direct result of blood surrounding the vessels. We postulate that direct invasion of VZV caused extensive inflammation of the vessel wall and aggressive tissue penetration resulting in necrotizing angiitis and intracranial haemorrhage. We suggest that VZV infection should be considered a potential risk factor for intracranial haemorrhage in children.
authors.affiliation: Department of Radiology, Great Ormond Street Hospital, UK.
authors.forename: Nasuda
authors.initials: N
authors.lastname: Danchaivijitr
authors.forename: Elena
authors.initials: E
authors.lastname: Miravet
authors.forename: Dawn E
authors.initials: DE
authors.lastname: Saunders
authors.forename: Tim
authors.initials: T
authors.lastname: Cox
authors.forename: Vijeya
authors.initials: V
authors.lastname: Ganesan
mesh_terms: D020771:Anterior Cerebral Artery / Q000473:pathology; D001167:Arteritis / Q000209:etiology / Q000821:virology; D006562:Herpes Zoster / Q000150:complications*; D014645:Herpesvirus 3, Human / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D007249:Inflammation; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000821:virology; D008297:Male; D009336:Necrosis; D012307:Risk Factors