Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus.
Suppressors of cytokine signalling (SOCS) proteins play important roles in the negative regulation of cytokine signal. We first searched for polymorphisms in SOCS-1, SOCS-3 and SOCS-5 genes, and examined the association of the polymorphisms with type 1 diabetes (T1D). As a result, we did not find any significant associations between SOCS genes and T1D.
Ni
R
R
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan.
Ihara
K
K
Miyako
K
K
Takemoto
M
M
Ishimura
M
M
Kohno
H
H
Matsuura
N
N
Yoshimura
A
A
Hara
T
T
D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D020641:Polymorphism, Single Nucleotide; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*
D050826:Suppressor of Cytokine Signaling Proteins