title: Gallbladder adenosquamous cell carcinoma: report of two cases.
abstract: Adenocarcinoma is the usual histological presentation of the very rare gallbladder carcinoma. Adenosquamous cell carcinoma accounts for less than 3.5% of gallbladder carcinomas, and is characterised by invasive growth, a reduced tendency for lymph node metastasis, an increased tendency for hepatic infiltration or liver metastasis, and a poorer prognosis than adenocarcinoma. We present two cases. The first patient presented to our institution with increased bilirubin levels and dilated intra- and extrahepatic bile ducts. Adenosquamous carcinoma of the gallbladder was diagnosed on the post-operative pathological specimen. After surgery, bilirubin levels decreased, but hepatic metastases occurred that did not respond to conventional chemotherapy. The second patient was admitted to our hospital with jaundice and abdominal pain. Abdominal computed tomography (CT) imaging showed marked thickening of the gallbladder with direct extension of a mass into the left liver lobe. Cytology specimens obtained with an endoscopic retrograde cholangiopancreatography (ERCP) procedure revealed a malignant epithelial tumour. The patient underwent surgery but the tumour was incompletely resected. A regimen of oral UFT (Tegafur + uracil) chemotherapy was begun. Serum bilirubin levels increased due to occlusion in the surgical area 15 weeks after the start of chemotherapy.
authors.affiliation: Baskent University Faculty of Medicine, Ankara, Turkey, Division of Medical Oncology. zaferakcali@yahoo.com
authors.forename: Z
authors.initials: Z
authors.lastname: Akcali
authors.forename: O
authors.initials: O
authors.lastname: Ozyilkan
authors.forename: H
authors.initials: H
authors.lastname: Sakalli
authors.forename: N
authors.initials: N
authors.lastname: Bal
authors.forename: T
authors.initials: T
authors.lastname: Noyan
mesh_terms: D001707:Biopsy, Needle; D018196:Carcinoma, Adenosquamous / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D005706:Gallbladder Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018570:Risk Assessment; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005641:Tegafur; D005472:Fluorouracil