title: Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers.
abstract: We demonstrate here the effective delivery of a dye payload into cells using 2-nm core gold nanoparticles, with release occurring via place exchange of glutathione onto the particle surface. In vitro experiments demonstrate effective release of drug analogues upon addition of glutathione. Cell culture experiments show rapid uptake of nanoparticle and effective release of payload. The role of glutathione in the release process was demonstrated through improved payload release upon transient increase in glutathione levels achieved via introduction of glutathione ethyl ester into the cell.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, 01003, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Hong
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Fernández
authors.forename: Byoung-jin
authors.initials: BJ
authors.lastname: Kim
authors.forename: Neil S
authors.initials: NS
authors.lastname: Forbes
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005978:Glutathione / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006046:Gold; D005978:Glutathione