Hepatocellular carcinoma missed on gadolinium enhanced MR imaging, discovered in liver explants: retrospective evaluation.
The main purpose of this study was to determine if hepatocellular carcinomas (HCCs) missed on prospective magnetic resonance (MR) study could be identified on retrospective MR analysis, and to determine the cause for misdiagnosis. Among 555 patients who underwent liver transplantation between 1993 and 2004, 279 were imaged with MR imaging and four of these revealed HCCs in explanted livers that were not reported on prospective MR reading. The main cause of missed lesions were suboptimal image quality due to inability of patients to suspend respiration; other causes were HCC misinterpreted as high-grade dysplastic nodule and isoenhancement of HCC on early phase images.
Karadeniz-Bilgili
Mirace Y
MY
Department of Radiology, University of North Carolina, Chapel Hill, North Carolina 27599-7510, USA.
Braga
Larissa
L
Birchard
Katherine R
KR
Gerber
David
D
Firat
Zeynep
Z
Woosley
John T
JT
Shrestha
Roshan
R
Semelka
Richard C
RC
D000328:Adult; D000368:Aged; D016477:Artifacts; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003287:Contrast Media; D003951:Diagnostic Errors; D005188:False Negative Reactions; D005260:Female; D005682:Gadolinium; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D003287:Contrast Media; D005682:Gadolinium