A photochemical snapshot of CD22 binding.
Identification of endogenous glycan-binding ligands for cell-surface receptors has been difficult. Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.
Yarema
Kevin J
KJ
Sun
Zhonghui
Z
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D010777:Photochemistry; D011134:Polysaccharides / Q000378:metabolism*; D011485:Protein Binding; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000378:metabolism*
D011134:Polysaccharides; D051918:Sialic Acid Binding Ig-like Lectin 2