title: Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection.
abstract: Drug hypersensitivity syndrome (DHS) is an idiosyncratic and life-threatening adverse drug reaction characterized by skin rash and multiorgan involvement. In rare cases, fulminant type1 diabetes mellitus (DM) may develop after DHS. Among proposed pathogenesis, human herpesvirus 6 (HHV-6) infections may play a role in the development of DHS. We report a case of DHS associated with HHV-6 reactivation, complicated with a rare sequela of irreversible fulminant type 1 DM. No diabetes-related autoantibodies were detected. Early detection and intervention for this serious complication should be given in patients with DHS. Fulminant type1 DM associated with DHS is reviewed. The role of HHV-6 in DHS associated with fulminant type 1 DM is also discussed.
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Chien-Chun
authors.initials: CC
authors.lastname: Chiou
authors.forename: Wen-Hung
authors.initials: WH
authors.lastname: Chung
authors.forename: Shuen-Iu
authors.initials: SI
authors.lastname: Hung
authors.forename: Li-Cheng
authors.initials: LC
authors.lastname: Yang
authors.forename: Hong-Shang
authors.initials: HS
authors.lastname: Hong
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D016883:Diabetic Ketoacidosis / Q000209:etiology; D003875:Drug Eruptions / Q000150:complications* / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D008297:Male; D012008:Recurrence; D019349:Roseolovirus Infections / Q000150:complications*; D014775:Virus Activation / Q000187:drug effects*