Aberrant CD8 expression in B-chronic lymphocytic leukemia: report of five cases.
The expression of T cell-associated antigens on B cell non-Hodgkin lymphoma is rare. We describe 5 cases of B-chronic lymphocytic leukemia (B-CLL) with aberrant expression of CD8 on B cells. These B-CLL presented a typical immunophenotype CD19+, CD23+, FMC7- and CD5+ (except for 1 case) with a monotypic expression of surface immunoglobulin light chain kappa. The CD8 expression was confirmed on B-CLL cells by two-color flow cytometry staining. We could not find coexpression of CD3 or CD4 on B-CLL cells. The clinical implications, the sensitivity to therapy and the prognostic outcome of this aberrant expression remains to be determined.
Parisi-Duchêne
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Laboratoire d'Hématologie-Hémostase, Hôpital Pasteur, Colmar, France. elisabeth.parisi@ch-colmar.rss.fr
Mazurier
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I
Moskovtchenko
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P
D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D016827:CD8 Antigens / Q000096:biosynthesis*; D005260:Female; D005434:Flow Cytometry; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged
D015703:Antigens, CD; D016827:CD8 Antigens; D007145:Immunoglobulin kappa-Chains