title: Impact of donor age and year of transplantation on graft and patient survival following liver transplantation for hepatitis C virus.
abstract: BACKGROUND
  Hepatitis C virus (HCV) infection has become the most common indication for liver transplantation (LT). Graft and patient survival are adversely affected by recurrent infection of the graft. Recent publications have described an inferior outcome for recently transplanted HCV patients and have highlighted the impact of advancing donor age on severity of recurrent HCV. The donor age at which a measurable impact on graft and patient outcome can be observed has not clearly been defined. In addition, the impact of donor age on graft and patient survival for non-HCV patients needs to be examined.
  
  
  METHODS
  We have examined a large European liver transplant database to define the impact of transplantation date and donor age on graft and patient survival for HCV patients (n = 4,736) and the impact for a comparison group of transplanted alcoholic liver disease patients (ALD, n = 5,406).
  
  
  RESULTS
  For the entire cohorts, graft and patient survival of HCV patients was inferior to ALD patients. Since 1987, there has been a steady and ongoing improvement in the outcome of transplanted ALD patients, an improvement not observed for HCV patients. Every year since 1989, there has been an increase in liver donor age. Graft and patient survival for both ALD and HCV cohorts was adversely affected by advancing donor age. Comparison of graft and patient survival for HCV and ALD cohorts was made according to donor age (donor age subgrouped <20, 20-30, 30-40, 40-50, 50-60 and >60 years of age). For donors younger than 40 years of age, HCV and ALD recipient graft and patient survival are not significantly different. For donors older than 40, HCV recipient graft survival is inferior to ALD graft survival, an inferiority that increases for each advancing decade of donor age. For donors older than 50 years, HCV recipient patient survival is inferior to ALD patient survival, an inferiority that increases when the donor age is greater than 60 years.
  
  
  CONCLUSIONS
  The results of liver transplantation for European HCV patients is inferior to a comparison group of ALD patients, and have not improved during the past 15 years. Liver donor age has increased significantly during that period. Advancing donor age has an adverse influence on graft and patient survival for ALD and HCV patients, but a significantly greater impact is observed for HCV patients when the donor is older than 40 years.
authors.affiliation: Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom.
authors.forename: David J
authors.initials: DJ
authors.lastname: Mutimer
authors.forename: Bridget
authors.initials: B
authors.lastname: Gunson
authors.forename: John
authors.initials: J
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
authors.forename: Peter
authors.initials: P
authors.lastname: Neuhaus
authors.forename: D
authors.initials: D
authors.lastname: Castaing
authors.forename: J C
authors.initials: JC
authors.lastname: Garcia-Valdecasas
authors.forename: M
authors.initials: M
authors.lastname: Salizzoni
authors.forename: Gonzalez E
authors.initials: GE
authors.lastname: Moreno
authors.forename: Darius
authors.initials: D
authors.lastname: Mirza
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000276:immunology*; D006526:Hepatitis C / Q000601:surgery*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D013997:Time Factors; D014019:Tissue Donors