Characterization of the cDNA Encoding alphaIIb and beta3 in normal horses and two horses with Glanzmann thrombasthenia.
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin alpha(IIb)beta3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.
Christopherson
P W
PW
Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Insalaco
T A
TA
van Santen
V L
VL
Livesey
L
L
Bourne
C
C
Boudreaux
M K
MK
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D018076:DNA, Complementary / Q000235:genetics*; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses; D039661:Integrin beta3 / Q000235:genetics*; D008969:Molecular Sequence Data; D040201:Platelet Membrane Glycoprotein IIb / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000662:veterinary; D013915:Thrombasthenia / Q000235:genetics / Q000662:veterinary*
D017931:DNA Primers; D018076:DNA, Complementary; D039661:Integrin beta3; D040201:Platelet Membrane Glycoprotein IIb