title: Inheritance of rupture of the cranial cruciate ligament in Newfoundlands.
abstract: OBJECTIVE
  To determine prevalence, level of inbreeding, heritability, and mode of inheritance for rupture of the cranial cruciate ligament (RCCL) in Newfoundlands.
  
  
  METHODS
  Retrospective and recruitment study.
  
  
  METHODS
  574 client-owned Newfoundlands.
  
  
  METHODS
  Medical records from January 1, 1996, to December 31, 2002, were evaluated for prevalence of RCCL. A pedigree was constructed by use of recruited Newfoundlands with RCCL status based on results of veterinary examination; level of inbreeding, heritability, and mode of inheritance were calculated.
  
  
  RESULTS
  Hospital prevalence for RCCL was 22%; dogs in the pedigree from the recruitment study had a mean level of inbreeding of 1.19 x 10(4), heritability of 0.27, and a possible recessive mode of inheritance with 51% penetrance for RCCL.
  
  
  CONCLUSIONS
  Identification of a genetic basis for RCCL in Newfoundlands provided evidence that investigators can now focus on developing methods to identify carriers to reduce the prevalence of RCCL.
authors.affiliation: Department of Animal Sciences, Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011-1250, USA.
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Wilke
authors.forename: Michael G
authors.initials: MG
authors.lastname: Conzemius
authors.forename: Brian P
authors.initials: BP
authors.lastname: Kinghorn
authors.forename: Paula E
authors.initials: PE
authors.lastname: Macrossan
authors.forename: Weiguo
authors.initials: W
authors.lastname: Cai
authors.forename: Max F
authors.initials: MF
authors.lastname: Rothschild
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D004285:Dogs / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D007178:Inbreeding; D008297:Male; D015995:Prevalence; D012421:Rupture / Q000453:epidemiology / Q000235:genetics / Q000601:surgery / Q000662:veterinary; D014481:United States / Q000453:epidemiology