title: Bap: a family of surface proteins involved in biofilm formation.
abstract: A group of surface proteins sharing several structural and functional features is emerging as an important element in the biofilm formation process of diverse bacterial species. The first member of this group of proteins was identified in a Staphylococcus aureus mastitis isolate and was named Bap (biofilm-associated protein). As common structural features, Bap-related proteins: (i) are present on the bacterial surface; (ii) show a high molecular weight; (iii) contain a core domain of tandem repeats; (iv) confer upon bacteria the capacity to form a biofilm; (v) play a relevant role in bacterial infectious processes; and (vi) can occasionally be contained in mobile elements. This review summarizes recent studies that have identified and assigned roles to Bap-related proteins in biofilm biology and virulence.
authors.affiliation: Laboratory of Microbial Biofilms, Instituto de Agrobiotecnología and Dpto. de Producción Agraria, Universidad Pública de Navarra-CSIC, Pamplona-31006, Spain. ilasa@unavarra.es
authors.forename: Iñigo
authors.initials: I
authors.lastname: Lasa
authors.forename: José R
authors.initials: JR
authors.lastname: Penadés
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity; D001424:Bacterial Infections / Q000382:microbiology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018441:Biofilms / Q000254:growth & development*; D006801:Humans; D020071:Interspersed Repetitive Sequences; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D010944:Plants / Q000382:microbiology; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; C425726:Bap protein, Staphylococcus aureus; D008565:Membrane Proteins; D037521:Virulence Factors