title: Ketotifen improves sperm motility and sperm morphology in male patients with leukocytospermia and unexplained infertility.
abstract: In an open, uncontrolled study, the effect of 12 weeks of daily administration of ketotifen, an antihistamine-like drug with a mast cell stabilizing effect, on the semen quality of 55 men with leukocytospermia and unexplained infertility was examined. After 4 weeks of treatment, white blood cell count dramatically diminished and was accompanied by a significant improvement in sperm motility. A significant increase of morphologically normal sperm cells was observed at 8 weeks of treatment, and these changes remained until at least 4 weeks after the end of treatment.
authors.affiliation: Unidad de Andrologia, Servicio de Urologia, Hospital Italiano de Rosario, Rosario, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Oliva
authors.forename: Luc
authors.initials: L
authors.lastname: Multigner
mesh_terms: D000328:Adult; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000473:pathology; D007665:Ketotifen / Q000008:administration & dosage*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*
chemical_list: D006634:Histamine H1 Antagonists; D007665:Ketotifen