Spatial profile of back-propagating action potential-evoked Ca2+ transients in basal dendrites.
Calcium influx in basal dendrites evoked by back-propagating action potentials is important for understanding the input-specific modulation of synaptic transmission. Calcium transients evoked by back-propagating action potentials were measured for the basal dendrites of layer II/III pyramidal neurons in visual cortex slices. In contrast to apical dendrites, the peak calcium transients evoked by a single somatic action potential increased with distance from the soma. The peak calcium transients evoked by bursts of back-propagating action potentials (three or five pulses, 20 Hz) were greater than those evoked by a single back-propagating action potential. These different spatial profiles for calcium transients triggered by back-propagating action potentials between apical and basal dendrites suggest that the segregated inputs from brain areas might be modulated in different ways, according to their synaptic location.
Cho
Kwang-Hyun
KH
Department of Physiology, College of Medicine, South Korea.
Kim
Myung-Jun
MJ
Yoon
Shin Hee
SH
Hahn
Sang June
SJ
Jo
Yang-Hyeok
YH
Kim
Myung-Suk
MS
Rhie
Duck-Joo
DJ
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D000814:Aniline Compounds / Q000493:pharmacokinetics; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism*; D003712:Dendrites / Q000187:drug effects / Q000502:physiology*; D003952:Diagnostic Imaging / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D005246:Feedback / Q000502:physiology; D005452:Fluoresceins / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D018408:Patch-Clamp Techniques / Q000379:methods; D017966:Pyramidal Cells / Q000166:cytology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014793:Visual Cortex / Q000166:cytology
D000814:Aniline Compounds; D005452:Fluoresceins; C503942:Oregon green 488 BAPTA-1; D002118:Calcium