title: Radioiodine therapy for thyroid cancer and hyperthyroidism in patients with end-stage renal disease on hemodialysis.
abstract: Treatment with radioactive iodine ((131)I) may be necessary for thyroid cancer or for hyperthyroidism in patients with end-stage renal disease who require hemodialysis. Because (131)I is cleared mainly by the kidneys in patients with normal renal function, many issues arise in patients who require (131)I treatment but who are on hemodialysis. This paper presents a case report of a patient on dialysis who required treatment with (131)I for thyroid cancer. We describe a mathematical model, which suggests that the treatment dose of (131)I for a patient with thyroid cancer on hemodialysis would be approximately 13%-28% of a typical empiric dose of (131)I for a patient with normal renal function. Also, we present a comprehensive review and discussion of the literature on patients who are receiving hemodialysis who were treated with (131)I for either thyroid cancer or hyperthyroidism. Using a multidisciplinary approach and special precautions, (131)I therapy can be administered safely and effectively for patients with thyroid cancer or hyperthyroidism who are receiving hemodialysis.
authors.affiliation: Georgetown University/Washington Hospital Center, Washington, DC, USA. jenpen27@yahoo.com
authors.forename: Jennifer P
authors.initials: JP
authors.lastname: Holst
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Burman
authors.forename: Frank
authors.initials: F
authors.lastname: Atkins
authors.forename: Jason G
authors.initials: JG
authors.lastname: Umans
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Jonklaas
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000532:radiotherapy*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008962:Models, Theoretical; D006435:Renal Dialysis; D013964:Thyroid Neoplasms / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes