title: Antibody responses to meningococcal (groups A, C, Y and W135) polysaccharide diphtheria toxoid conjugate vaccine in children who previously received meningococcal C conjugate vaccine.
abstract: A randomised, modified, double-blind trial was conducted in children 2 to < 5 years of age to evaluate immunogenicity and reactogenicity of a meningococcal (serogroups A, C, Y, W135) diphtheria toxoid conjugate vaccine (MCV-4) in healthy children previously vaccinated with a monovalent meningococcal C conjugate vaccine. Participants received one dose of either MCV-4 or Haemophilus influenzae type b vaccine (Hib vaccine, control group). Serum bactericidal antibodies (SBA) were determined in sera obtained before and approximately 28 days following vaccination. MCV-4 was highly immunogenic for serogroups A, C, Y and W135, the response to serogroup C being consistent with a booster response in participants primed with monovalent C conjugate vaccine. No major between-group differences in solicited local and systemic reactions or adverse events (AEs).
authors.affiliation: Research Centre for Child Health, St. Bartholomew's and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. haitham.elbashir@haringey.nhs.uk
authors.forename: Haitham
authors.initials: H
authors.lastname: El Bashir
authors.forename: Paul T
authors.initials: PT
authors.lastname: Heath
authors.forename: Thomas
authors.initials: T
authors.lastname: Papa
authors.forename: Jens U
authors.initials: JU
authors.lastname: Ruggeberg
authors.forename: Nik
authors.initials: N
authors.lastname: Johnson
authors.forename: Ruchi
authors.initials: R
authors.lastname: Sinha
authors.forename: Gail
authors.initials: G
authors.lastname: Balfour
authors.forename: Robert
authors.initials: R
authors.lastname: Booy
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000276:immunology; D004311:Double-Blind Method; D006801:Humans; D007156:Immunologic Memory; D008585:Meningitis, Meningococcal / Q000276:immunology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D009345:Neisseria meningitidis / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology; D018074:Vaccines, Conjugate / Q000009:adverse effects / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate; C410218:serogroup C meningococcal conjugate vaccine