title: Diabetes mellitus and impaired glucose regulation in the Canary Islands (Spain): prevalence and associated factors in the adult population of Telde, Gran Canaria.
abstract: OBJECTIVE
  To estimate the prevalence and the determinants of diabetes mellitus and impaired glucose regulation (IGR) in an adult Canarian population.
  
  
  METHODS
  Cross-sectional study. One thousand and thirty subjects aged 30-82 years were randomly selected. Participants completed a survey questionnaire and underwent blood pressure measurements, anthropometry, blood samples, and a 75-g standardized oral glucose tolerance test.
  
  
  RESULTS
  The age-standardized prevalence of diabetes was 15.8% (95% confidence interval: 11.8-19.8) in men and 10.6% (7.1-14.1) in women. Total prevalence was 13.2% (11.1-15.2). Among individuals with diabetes, 55.4% of men and 38.2% of women were not previously diagnosed. The age-standardized prevalences of impaired glucose tolerance and impaired fasting glycaemia were 11.4% (9.5-13.4) and 2.8% (1.8-3.8), respectively. In multivariate analyses, age, waist circumference, serum triglycerides, and familial history of diabetes were independently associated with diabetes in both sexes, while a value of C-reactive protein (CRP) >/= 1 mg/l showed an association with diabetes, but only in men. Age and triglycerides were related to impaired glucose regulation (IGR) in both sexes, waist circumference was related to IGR exclusively in men, and familial diabetes exclusively in women. Statistically significant interactions between gender and both CRP and triglycerides were found with respect to diabetes, and between gender and both waist circumference and triglycerides for IGR.
  
  
  CONCLUSIONS
  Compared with the rest of Spain, the prevalence of diabetes is moderately increased in this area of the Canary Islands. Along with other well-established risk factors, CRP was independently associated with diabetes, but only in the male population.
authors.affiliation: Section of Endocrinology and Nutrition, Hospital Universitario Insular, Las Palmas de Gran Canaria, Gran Canaria, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Boronat
authors.forename: V F
authors.initials: VF
authors.lastname: Varillas
authors.forename: P
authors.initials: P
authors.lastname: Saavedra
authors.forename: V
authors.initials: V
authors.lastname: Suárez
authors.forename: E
authors.initials: E
authors.lastname: Bosch
authors.forename: A
authors.initials: A
authors.lastname: Carrillo
authors.forename: F J
authors.initials: FJ
authors.lastname: Nóvoa
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001266:Atlantic Islands / Q000453:epidemiology; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology* / Q000378:metabolism; D005192:Family Health; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017678:Sex Distribution; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D005947:Glucose