A study on stability of mestranol.
Mestranol, a synthetic oestrogcn, is an oral contraceptive given alongwith progestogens. It is light, heat and air sensitive and on uv irradiation new polymeric species of glucosiduronate and sulphate conjugate are formed. The new species fractions of mestranol are separatable over sephadex in column chromatography and characterized by analytical techniques employed in this investigation. This investigation is aimed to study formation of these species quantitatively for stability induced formulations.
Ahmad
T
T
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270.
Akhtar
S
S
Haider
S
S