title: Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human.
abstract: c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin beta(7), and ARK5 were up-regulated in c-Maf transgenic lymphoma cells. Furthermore, 60% of human T-cell lymphomas (11 of 18 cases), classified as angioimmunoblastic T-cell lymphoma, were found to express c-Maf. These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation.
authors.affiliation: Department of Anatomy and Embryology, Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Morito
authors.forename: Keigyou
authors.initials: K
authors.lastname: Yoh
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujioka
authors.forename: Takako
authors.initials: T
authors.lastname: Nakano
authors.forename: Homare
authors.initials: H
authors.lastname: Shimohata
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Yamada
authors.forename: Atsuko
authors.initials: A
authors.lastname: Maeda
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Suzuki
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Imagawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitsuya
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Esumi
authors.forename: Akio
authors.initials: A
authors.lastname: Koyama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Mori
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D056742:Cyclin D2; D016213:Cyclins / Q000096:biosynthesis; D020869:Gene Expression Profiling; D006801:Humans; D039641:Integrin beta Chains / Q000096:biosynthesis; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D011494:Protein Kinases / Q000096:biosynthesis; D051257:Proto-Oncogene Proteins c-maf / Q000096:biosynthesis* / Q000502:physiology; D012097:Repressor Proteins / Q000096:biosynthesis; D015854:Up-Regulation
chemical_list: C080336:CCND2 protein, human; C486196:Ccnd2 protein, mouse; D056742:Cyclin D2; D016213:Cyclins; D039641:Integrin beta Chains; C495607:MAF protein, human; C495608:Maf protein, mouse; D051257:Proto-Oncogene Proteins c-maf; D012097:Repressor Proteins; C091368:integrin beta7; D011494:Protein Kinases; C470845:NUAK1 protein, human