Nanotechnologies for biomolecular detection and medical diagnostics.
Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.
Cheng
Mark Ming-Cheng
MM
Division of Hematology and Oncology, Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus OH 43210-1002, USA.
Cuda
Giovanni
G
Bunimovich
Yuri L
YL
Gaspari
Marco
M
Heath
James R
JR
Hill
Haley D
HD
Mirkin
Chad A
CA
Nijdam
A Jasper
AJ
Terracciano
Rosa
R
Thundat
Thomas
T
Ferrari
Mauro
M
D001704:Biopolymers / Q000737:chemistry*; D019937:Diagnostic Techniques and Procedures / Q000295:instrumentation*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods; D012680:Sensitivity and Specificity; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties
D001704:Biopolymers; D012825:Silicon