Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus.
Earlier, we reported that oils rich in omega-3 eicosapentaenoic acid and docosahexaenoic acid and omega-6 gamma-linolenic acid and arachidonic acid prevented the development of alloxan-induced diabetes mellitus in experimental animals. Here we report the results of our studies with pure saturated stearic acid (SA), monounsaturated oleic acid (OA) and omega-6 arachidonic acid (AA) on alloxan-induced diabetes mellitus in Wistar male rats. Prior oral supplementation with AA prevented alloxan-induced diabetes mellitus, whereas both SA and OA were ineffective. Cyclo-oxygenase (COX) and lipoxygenase (LO) inhibitors did not block this protective action of AA against alloxan-induced diabetes, suggesting that both prostaglandins and leukotrienes are not involved, and that AA by itself is effective. Furthermore, AA restored the anti-oxidant status to normal range in various tissues. These results suggest that AA protects pancreatic beta cells against alloxan-induced diabetes in experimental animals by attenuating oxidant stress.
Suresh
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Y
UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA.
Das
Undurti N
UN
D000496:Alloxan; D000818:Animals; D016718:Arachidonic Acid / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D009637:Masoprocol / Q000494:pharmacology; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism; D019301:Oleic Acid / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013229:Stearic Acids / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D008054:Lipid Peroxides; D010743:Phospholipids; D013229:Stearic Acids; D016718:Arachidonic Acid; D019301:Oleic Acid; D009569:Nitric Oxide; D019344:Lactic Acid; C031183:stearic acid; D008315:Malondialdehyde; D000496:Alloxan; D009637:Masoprocol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005982:Glutathione Transferase; D007213:Indomethacin