(P)PARsing epidermal development.
Overexpression of PPAR-alpha, a developmental transcription factor important in epidermal embryogenesis, in basal keratinocytes causes epidermal thinning when activated constitutively during development, but not if activated in adults; and lack of PPAR-alpha transiently delays stratum corneum formation within a window late in epidermal development (day 18.5 to birth). In contrast, pharmacologic activation of PPAR-alpha inhibits proliferation and induces differentiation in mouse epidermis regardless of developmental stage. Thus, PPAR-alpha is an important regulator of epidermal homeostasis.
Dubrac
Sandrine
S
Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria. sandrine.dubrac@uibk.ac.at
Schmuth
Matthias
M
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004817:Epidermis / Q000254:growth & development* / Q000378:metabolism; D015603:Keratinocytes / Q000378:metabolism; D051379:Mice; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation
D047493:PPAR alpha