A brief history of cell labelling.
The term cell labelling is usually used in the context of labelled leukocytes for imaging inflammation and labelled platelets for imaging thrombosis. Erythrocyte labelling for in vitro measurements of red cell life span, in vivo measurements of splenic red cell pooling, radionuclide ventriculography and imaging sites of bleeding has developed rather separately and has a different history. Labelled platelets and leukocytes were originally developed for cell kinetic studies. Since the current-day applications of labelled platelets and leukocytes depend on a clear understanding of cell kinetics, these classical studies are important and relevant to the history of cell labelling.
Peters
A M
AM
School of Applied Physiology, Brighton and Sussex Medical School, Royal Sussex County Hospital, Eastern Road, Brighton BN2 4BE, UK. a.m.peters@bsms.ac.uk
D001773:Blood Cells / Q000000981:diagnostic imaging*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008297:Male; D009683:Nuclear Medicine / Q000266:history*; D049268:Positron-Emission Tomography / Q000266:history*; D013194:Staining and Labeling / Q000266:history*