Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum.
The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. Drug release from hot-melt extruded (HME) tablets containing either chitosan or xanthan gum was pH and buffer species dependent and the release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also exhibited pH and buffer species dependent release. In contrast, the HME tablets containing both chitosan and xanthan gum exhibited pH and buffer species independent sustained release. When placed in 0.1N HCl, the HME tablets formed a hydrogel that functioned to retard drug release in subsequent pH 6.8 and 7.4 phosphate buffers even when media contained high ionic strength, whereas tablets without chitosan did not form a hydrogel to retard drug release in 0.1N HCl. The HME tablets containing both chitosan and xanthan gum showed no significant change in drug release rate when stored at 40 degrees C for 1 month, 40 degrees C and 75% relative humidity (40 degrees C/75% RH) for 1 month, and 60 degrees C for 15 days.
Fukuda
Mamoru
M
Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 78712, USA. mamoru.fukuda@mb.kyorin-pharm.co.jp
Peppas
Nicholas A
NA
McGinity
James W
JW
D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D002744:Chlorpheniramine / Q000737:chemistry; D003692:Delayed-Action Preparations; D006634:Histamine H1 Antagonists / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D013816:Thermodynamics
D003692:Delayed-Action Preparations; D006634:Histamine H1 Antagonists; D020100:Hydrogels; D011135:Polysaccharides, Bacterial; D013607:Tablets; D002744:Chlorpheniramine; D048271:Chitosan; C002563:xanthan gum