title: Effects of methanol extracts of Caesalpinia bonducella and Bauhinia racemosa on hematology and hepatorenal function in mice.
abstract: The aim of the present investigation deals with the hematology and hepatorenal function of Caesalpinia bonducella Flem. and Bauhinia racemosa Lam. belonging to the Family: Caesalpiniaceae, and used in the traditional system of medicine. The tribal people of Kolli Hills, Tamil Nadu, India, use the leaves of Caesalpinia bonducella and the stem bark of Bauhinia racemosa in combination with some other herbs for the treatment of various tumors, liver disorders, inflammation and some other diseases. In ancient Ayurveda medicine these plants were mentioned to possess antitumor agents. Since there are no scientific reports regarding the toxicological aspects of these plants, the present investigation deals with the sub-chronic toxicity studies of a methanol extract of Caesalpinia bonducella (MECB) leaves and Bauhinia racemosa (MEBR) stem bark in Swiss albino mice. The MECB and MEBR were administered intraperitoneally (i.p) to Swiss albino mice twice a week for thirteen weeks. No significant alterations in hematological, biochemical and histopathological parameters were observed in the MECB- and MEBR-treated groups at the doses of 100 and 200 mg/kg body weight. Administration of MECB and MEBR at the dose of 400 mg/kg body weight elevated the levels of serum enzymes and altered the hematological parameters. Our results suggested that MECB and MEBR at doses 100 and 200 mg/kg body weight did not induce any toxic effects in the mice. Adverse effect was noted at the dose of 400 mg/kg body weight.
authors.affiliation: Division of Pharmacology and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. sambathju2002@yahoo.co.in
authors.forename: Ramanathan Sambath
authors.initials: RS
authors.lastname: Kumar
authors.forename: Malaya
authors.initials: M
authors.lastname: Gupta
authors.forename: Upal Kanti
authors.initials: UK
authors.lastname: Mazumdar
authors.forename: Yerra
authors.initials: Y
authors.lastname: Rajeshwar
authors.forename: Thangavel Siva
authors.initials: TS
authors.lastname: Kumar
authors.forename: Periaswamy
authors.initials: P
authors.lastname: Gomathi
authors.forename: Rathnamala
authors.initials: R
authors.lastname: Roy
mesh_terms: D000818:Animals; D036481:Bauhinia; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D029911:Caesalpinia; D004353:Drug Evaluation, Preclinical; D004435:Eating / Q000187:drug effects; D004798:Enzymes / Q000097:blood; D006400:Hematocrit; D006403:Hematologic Tests; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D004798:Enzymes; D010936:Plant Extracts