Serum alkaline phosphatase activity in Scottish Terriers versus dogs of other breeds.
OBJECTIVE
To determine whether Scottish Terriers have higher serum alkaline phosphatase (ALP) activities and a higher prevalence of diseases commonly associated with high serum ALP activity than do dogs of other breeds.


METHODS
Retrospective case-control study.


METHODS
85 Scottish Terriers and 340 age-matched control dogs that were not Scottish Terriers.


METHODS
Medical records were reviewed, and data for year of evaluation, age, sex, breed, serum ALP activity, and final diagnosis were recorded.


RESULTS
Scottish Terriers had a significantly higher mean serum ALP activity than did control dogs (1,520 U/L vs 306 U/L). Regardless of breed, dogs that had a disease commonly associated with high serum ALP activity had a significantly higher mean serum ALP activity than did dogs without such diseases (1,304 U/L vs 427 U/L). Scottish Terriers were 2.4 times as likely to have a disease commonly associated with high serum ALP activity than were control dogs, but Scottish Terriers with diseases commonly associated with high serum ALP activity had a significantly higher mean ALP activity than did control dogs with such diseases (2,073 U/L vs 909 U/L), and Scottish Terriers without such diseases had a significantly higher mean serum ALP activity than did control dogs without such diseases (1,349 U/L vs 228 U/L).


CONCLUSIONS
Results suggest that Scottish Terriers have higher serum ALP activities than do dogs of other breeds. Although Scottish Terriers also have a higher prevalence of diseases associated with high serum ALP activity, this alone did not explain the higher mean serum ALP activity in the breed.
Nestor
Derek D
DD
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823, USA.
Holan
Kate M
KM
Johnson
Cheri A
CA
Schall
William
W
Kaneene
John B
JB
D000308:Adrenocortical Hyperfunction / Q000201:enzymology / Q000662:veterinary; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001947:Breeding; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000201:enzymology / Q000662:veterinary; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs / Q000097:blood* / Q000235:genetics*; D005260:Female; D008107:Liver Diseases / Q000201:enzymology / Q000662:veterinary; D008297:Male; D012189:Retrospective Studies
D000469:Alkaline Phosphatase