The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.
Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.
McDonald
J Matthew
JM
Department of Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Dunlap
Sarah
S
Cogdell
David
D
Dunmire
Valerie
V
Wei
Qingyi
Q
Starzinski-Powitz
Anna
A
Sawaya
Raymond
R
Bruner
Janet
J
Fuller
Gregory N
GN
Aldape
Kenneth
K
Zhang
Wei
W
D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D002465:Cell Movement; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D018895:Microsatellite Repeats; D009154:Mutation; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology*; D016133:Polymerase Chain Reaction; D014162:Transfection
C483313:AJAP1 protein, human; D015815:Cell Adhesion Molecules; D008565:Membrane Proteins