title: Linkage disequilibrium sharing and haplotype-tagged SNP portability between populations.
abstract: The discovery of the block-like structure of linkage disequilibrium (LD) in human populations holds the promise of delineating the etiology of common diseases. However, understanding the magnitude, mechanism, and utility of between-population LD sharing is critical for future genome-wide association studies. In this study, substantial LD sharing between six non-African populations was observed, although much less between African-American and non-African, based on 20,000 SNPs of chromosome 21. We also demonstrated the respective roles of recombination and demographic events in shaping LD sharing. Furthermore, we showed that the haplotype-tagged SNPs chosen from one population are portable to the others in East Asia. Therefore, we concluded that the magnitude of LD sharing between human populations justifies the use of representative populations for selecting haplotype-tagged SNPs in genome-wide association studies of complex diseases.
authors.affiliation: Chinese National Human Genome Center, Shanghai 201203, China. huangwei@chgc.sh.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Yungang
authors.initials: Y
authors.lastname: He
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yangfan
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Xun
authors.initials: X
authors.lastname: Chu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Yayun
authors.initials: Y
authors.lastname: Shen
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xiong
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Wen
authors.forename: Ji
authors.initials: J
authors.lastname: Qian
authors.forename: Wentao
authors.initials: W
authors.lastname: Yuan
authors.forename: Chenhui
authors.initials: C
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Hongquan
authors.initials: H
authors.lastname: Jiang
authors.forename: Guoping
authors.initials: G
authors.lastname: Zhao
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Jin
mesh_terms: D000349:Africa; D000465:Algorithms; D044383:Black People; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D016678:Genome; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D015233:Models, Statistical; D008962:Models, Theoretical; D020641:Polymorphism, Single Nucleotide; D001741:Black or African American