title: Effect of diethylsulfoxide on the thermal denaturation of DNA.
abstract: DNA thermal denaturation has been investigated in aqueous solutions of diethylsulfoxide (DESO) by means of UV-vis and densimetry methods. It is suggested that, on the one hand, the structural change of entire solutions and, on the other hand, a direct interaction of DESO with DNA are responsible for the observed peculiar behavior. The results obtained were compared with those of dimethylsulfoxide (DMSO), also known from literature.
authors.affiliation: Department of Chemistry, Yerevan State University, 375049 Yerevan, Armenia. shmarkar@ysu.am
authors.forename: Shiraz A
authors.initials: SA
authors.lastname: Markarian
authors.forename: Arpine M
authors.initials: AM
authors.lastname: Asatryan
authors.forename: Karine R
authors.initials: KR
authors.lastname: Grigoryan
authors.forename: Hasmik R
authors.initials: HR
authors.lastname: Sargsyan
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA; D003720:Densitometry; D004121:Dimethyl Sulfoxide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006358:Hot Temperature; D009691:Nucleic Acid Denaturation; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013454:Sulfoxides / Q000494:pharmacology; D013950:Thymus Gland / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D012996:Solutions; D013454:Sulfoxides; C454662:diethyl sulfoxide; D014867:Water; D004247:DNA; D004121:Dimethyl Sulfoxide