title: Dendritic peptide release and peptide-dependent behaviours.
abstract: Neuropeptides that are released from dendrites, such as oxytocin and vasopressin, function as autocrine or paracrine signals at their site of origin, but can also act at distant brain targets to evoke long-lasting changes in behaviour. Oxytocin, for instance, has profound effects on social bonding that are exerted at sites that richly express oxytocin receptors, but which are innervated by few, if any, oxytocin-containing projections. How can a prolonged, diffuse signal have coherent behavioural consequences? The recently demonstrated ability of neuropeptides to prime vesicle stores for activity-dependent release could lead to a temporary functional reorganization of neuronal networks harbouring specific peptide receptors, providing a substrate for long-lasting effects.
authors.affiliation: Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK. mike.ludwig@ed.ac.uk
authors.forename: Mike
authors.initials: M
authors.lastname: Ludwig
authors.forename: Gareth
authors.initials: G
authors.lastname: Leng
mesh_terms: D000818:Animals; D019898:Autocrine Communication / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D009479:Neuropeptides / Q000502:physiology*; D010121:Oxytocin / Q000502:physiology; D013997:Time Factors; D014667:Vasopressins / Q000502:physiology
chemical_list: D009479:Neuropeptides; D014667:Vasopressins; D010121:Oxytocin