[The genetic determinism of polygenic diseases].
Progress in molecular biology has opened the way to identifying genes involved in predisposition to multigene diseases. The two methods currently used for this purpose--analysis of candidate genes and systematic genomic screening--have given interesting but only very partial results. The problem is complicated by the large number of genes involved, their low penetrance, and linkage disequilibrium.
Bach
Jean-François
JF
D001327:Autoimmune Diseases / Q000235:genetics; D004777:Environment; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D020412:Multifactorial Inheritance