Bilateral uveitis manifesting as a complication of chronic graft-versus-host disease after allogeneic bone marrow transplantation.
OBJECTIVE
To document the rare occurrence of uveitis presumed secondary to chronic graft-versus-host disease (cGVHD).


METHODS
Observational case report.


RESULTS
A 52-year-old Filipino male who had undergone allogeneic BMT 10 years earlier presented with bilateral uveitis and biopsy-proven cutaneous cGVHD. There was no evidence of infection or other immune-related causes and the inflammation had a temporal correlation with his dermatological GVHD. The patient responded to treatment with oral cyclosporin A.


CONCLUSIONS
The coexistence of uveitis and cGVHD is rare. The ophthalmologist should be aware of such an association and work together with the oncologist to treat these patients appropriately.
Wertheim
Michael
M
The Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Rosenbaum
James T
JT
D000208:Acute Disease; D001706:Biopsy; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007951:Leukemia, Myeloid / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014184:Transplantation, Homologous; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine