title: BTLA, a new inhibitory B7 family receptor with a TNFR family ligand.
abstract: B and T lymphocyte attenuator (BTLA), identified as an immune inhibitory receptor recently, plays widespread roles on T and B cells. Emerging evidence has generated plentiful information on the mechanisms which BTLA mediates negative regulation in immune responses and involves in a variety of physiological and pathological processes. The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases.
authors.affiliation: Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zeng
authors.forename: Tinghe
authors.initials: T
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhen
authors.forename: Xue Pei
authors.initials: XP
authors.lastname: Xia
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008024:Ligands; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
chemical_list: D008024:Ligands; D011971:Receptors, Immunologic; D018124:Receptors, Tumor Necrosis Factor