title: Proton beam therapy for iris melanoma: a review of 15 cases.
abstract: OBJECTIVE
  To report results of proton beam therapy for iris melanoma.
  
  
  METHODS
  A retrospective case series of 15 patients with nonresectable iris melanomas treated with proton beam therapy between August 1998 and August 2004. The main outcome measures were (1) local tumour control, (2) complications, and (3) eye retention.
  
  
  RESULTS
  Of the 15 cases, 11 patients showed documented growth (including two cases of local recurrence following iridocyclectomy) while a further three cases were biopsy-proven melanoma. One patient presented with a newly acquired vascular nodule of the iris associated with angle seeding and glaucoma. Tumour control at mean follow-up of 34 months was 93% (14 of 15 eyes). Common complications included glaucoma in 53% (five patients had glaucoma prior to irradiation), dry eye (27%) and cataract in three patients (20%). Eye retention was possible in 80% (12 cases).
  
  
  CONCLUSIONS
  Proton beam therapy is an effective treatment for cases of nonresectable iris melanoma. The major complications are cataract and glaucoma.
authors.affiliation: Ocular Oncology Clinic, Royal Hallamshire Hospital, Sheffield, UK. Paul.Rundle@sth.nhs.uk
authors.forename: P
authors.initials: P
authors.lastname: Rundle
authors.forename: A D
authors.initials: AD
authors.lastname: Singh
authors.forename: I
authors.initials: I
authors.lastname: Rennie
mesh_terms: D000293:Adolescent; D000328:Adult; D002386:Cataract / Q000209:etiology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000209:etiology; D006801:Humans; D015811:Iris Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D061766:Proton Therapy; D011522:Protons / Q000009:adverse effects; D011832:Radiation Injuries / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011522:Protons