Specific probes for chemokine receptors.
Chemokine receptors have attracted a good deal of public attention as important therapeutic targets for many diseases and disorders. In this issue of Chemistry & Biology, Kumar and colleagues propose a new concept of synthetic modular modifications to generate unnatural chemokines, which exhibit high receptor selectivity .
Tamamura
Hirokazu
H
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Japan.
Tsutsumi
Hiroshi
H
D000818:Animals; D018925:Chemokines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008024:Ligands; D019707:Receptors, Chemokine / Q000378:metabolism*
D018925:Chemokines; D008024:Ligands; D019707:Receptors, Chemokine