title: Recurrent hyponatremia after intrathecal methotrexate not related to antidiuretic hormone: is a natriuretic peptide activated?
abstract: We report the development of recurrent hyponatremia after intrathecal methotrexate that was not associated with elevated levels of antidiuretic hormone. We speculate that a central nervous system natriuretic peptide may be involved in the pathogenesis of the naturesis following intrathecal methotrexate.
authors.affiliation: Hypertension, Nephrology, Dialysis and Transplantation Clinic, Auburn University, Opelika, AL 36801, USA. hndt512@bellsouth.net
authors.forename: Charles
authors.initials: C
authors.lastname: Diskin
authors.forename: Linda M
authors.initials: LM
authors.lastname: Dansby
authors.forename: Lautrec
authors.initials: L
authors.lastname: Radcliff
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Carter
authors.forename: Edith
authors.initials: E
authors.lastname: Graves
authors.forename: Allen
authors.initials: A
authors.lastname: Graves
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007278:Injections, Spinal; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D045265:Natriuretic Peptides / Q000378:metabolism*; D012008:Recurrence; D014667:Vasopressins / Q000502:physiology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D045265:Natriuretic Peptides; D014667:Vasopressins; D008727:Methotrexate