title: Clinical application of rapid assay of interleukin-6 in influenza-associated encephalopathy.
abstract: The characteristics of influenza-associated encephalopathy is the high mortality and nimble progress with coma which appears in general cases within 48 hours. Most of patients show no abnormalities in the standard blood checks on admission or in early stage. In this study we investigated if a rapid assay of interleukin (IL)-6 is useful in influenza-associated encephalopathy in early stages. The levels of IL-6 in patients with influenza-associated encephalopathy did not show any significant difference compared with those in patients with febrile convulsion and rotavirus-associated convulsion. However the levels of IL-6 in severe cases were significantly higher than those of mild cases with influenza-associated encephalopathy. Consequently the rapid assay of serum IL-6 is useful to evaluate and decide the therapies.
authors.affiliation: Department of Paediatrics, Tokyo Medical University, Japan.
authors.forename: Mikage
authors.initials: M
authors.lastname: Nakamura
authors.forename: Gaku
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ioi
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Kashiwagi
authors.forename: Kouji
authors.initials: K
authors.lastname: Takekuma
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
authors.forename: Mizuho
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
mesh_terms: D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000097:blood* / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D004760:Enterocolitis / Q000097:blood / Q000628:therapy / Q000821:virology; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007251:Influenza, Human / Q000097:blood* / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D012401:Rotavirus / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000097:blood / Q000628:therapy / Q000821:virology; D012640:Seizures / Q000097:blood / Q000628:therapy / Q000821:virology; D003294:Seizures, Febrile / Q000097:blood / Q000628:therapy / Q000821:virology; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D015850:Interleukin-6