title: Assessment of the efficacy of cryosurgery in the treatment of granuloma faciale.
abstract: BACKGROUND
  Granuloma faciale (GF) is an uncommon dermatosis of unknown pathogenesis. Multiple treatments have been proposed with varying results. We report nine cases treated successfully with cryosurgery and we review the literature.
  
  
  OBJECTIVE
  To study the efficacy, tolerability and safety of cryosurgery techniques in the treatment of GF.
  
  
  METHODS
  Nine immunocompetent adults with GF were treated by cryosurgery. The initiation of the therapy was preceded by a 60-day washout period in all subjects using other medication. Two different techniques were used (open-spray and contact cryo-probe).
  
  
  RESULTS
  All patients were treated successfully. Apart from mild postinflammatory hypopigmentation in two patients that resolved within 4 months, no other adverse event was mentioned. During an average 24-month follow-up period after the integration of therapy, no recurrences were observed.
  
  
  CONCLUSIONS
  Cryosurgery is an efficient, safe, inexpensive, easily used method for this uncommon dermatosis, which can be proposed as a treatment of first intention.
authors.affiliation: Department of Cryosurgery, A. Sygros Hospital, 5I. Dragoumi Str, 16121, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Panagiotopoulos
authors.forename: V
authors.initials: V
authors.lastname: Anyfantakis
authors.forename: E
authors.initials: E
authors.lastname: Rallis
authors.forename: V
authors.initials: V
authors.lastname: Chasapi
authors.forename: P
authors.initials: P
authors.lastname: Stavropoulos
authors.forename: C
authors.initials: C
authors.lastname: Boubouka
authors.forename: A
authors.initials: A
authors.lastname: Katsambas
mesh_terms: D000328:Adult; D003452:Cryosurgery; D004803:Eosinophilic Granuloma / Q000473:pathology / Q000601:surgery*; D005148:Facial Dermatoses / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome