title: [A case of corticobasal degeneration that progressed from primary progressive aphasia].
abstract: A 65-year-old woman began to experience slowly progressive speech disturbance from 2001. She was admitted to our hospital for examination on May 2003. She had dysprosody, paragraphia, and mild disturbance in comprehension of spoken language. Repetition was preserved. No clear paraphasia was found. Calculation was disturbed, but there were no other neurological abnormalities including apraxia and agnosia. Brain MRI showed atrophy of the left frontal and parietal lobes. 99mTc-ECD SPECT showed decreased blood flow in the left frontal lobe and parietal lobe, especially in the Broca area and supplemental motor cortex. Primary progressive aphasia was diagnosed, because aphasia lasted for 2 years without other neurological deficits, and her daily activity was well preserved. During follow up, facial apraxia appeared from December 2003, and limb apraxia appeared from May 2004, followed by rigidity predominantly in the right upper limb and dementia. She was diagnosed as having corticobasal degeneration (CBD). The second SPECT on December 2004 showed progression of the decrease in cerebral flow at the same area showed by the first SPECT. SPECT is useful examination to predict the progress of the disease because the decrease of blood flow was recognized before the progression to CBD.
authors.affiliation: Department of Neurology, Division of Neuroscience, Biophysical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawarabayashi
authors.forename: Etsuro
authors.initials: E
authors.lastname: Matsubara
authors.forename: Isao
authors.initials: I
authors.lastname: Nagano
authors.forename: Mikio
authors.initials: M
authors.lastname: Shoji
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000175:diagnosis* / Q000523:psychology; D001480:Basal Ganglia Diseases / Q000175:diagnosis* / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging*; D002540:Cerebral Cortex / Q000473:pathology; D003545:Cysteine / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000523:psychology; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine