title: Resistant pure red cell aplasia after allogeneic bone marrow transplantation with major ABO mismatch treated by purified CD34+ cell infusion.
abstract: We report a case of pure red cell aplasia (PRCA) subsequent to an allogeneic bone marrow transplantation with a major ABO mismatch, which was resistant to the standard treatment options such as plasma exchange, erythropoietin and changes in the immunosuppressive treatment. Accordingly, two cycles of Rituximab therapy were administered without success. The patient had a chronic graft-vs.-host disease of the liver, which meant that an additional donor leukocyte infusion could not be introduced. Instead, purified CD34(+) cells were administered after fludarabine and antithymocyte globulin therapy. As a result, the PRCA was resolved and the antidonor isohemagglutinin titer became undetectable.
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hyun-Young
authors.initials: HY
authors.lastname: Woo
authors.forename: Chang-Ki
authors.initials: CK
authors.lastname: Min
authors.forename: Se-Min
authors.initials: SM
authors.lastname: Lee
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Cho
authors.forename: Seong-Yong
authors.initials: SY
authors.lastname: Kim
authors.forename: Seok
authors.initials: S
authors.lastname: Lee
authors.forename: Jong-Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Woo-Sung
authors.initials: WS
authors.lastname: Min
authors.forename: Chun-Choo
authors.initials: CC
authors.lastname: Kim
authors.forename: Yonggu
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D018952:Antigens, CD34 / Q000276:immunology*; D016026:Bone Marrow Transplantation; D004921:Erythropoietin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017708:Leukocyte Transfusion; D019300:Medical Errors; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D000069283:Rituximab; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018952:Antigens, CD34; D004921:Erythropoietin; D000069283:Rituximab; D014740:Vidarabine; C024352:fludarabine