[Development of immunopathology in patients with yersinia infection].
OBJECTIVE
To evaluate clinical significance of changes in IL-6 concentration and neopterin in peripheral blood of patients for prognosis of the course and outcome of yersinia infection (YI).


METHODS
Clinical examination and laboratory tests, 1-5-year follow-up were conducted in 68 patients with a cyclic, recurrent and lingering course of the disease. IL-6 and neopterin concentrations were measured in the course of the disease.


RESULTS
Dynamic control over IL-6 concentrations in the blood of patients with yersinia infection provides information predicting the disease course and prognosis. Blood concentrations of neopterin are of help in prognostication of long-term outcomes of acute infection.


CONCLUSIONS
Pathological syndromes forming in acute stage of yersinia infection are related to interleukin-dependent immunopathology.
Shestakova
I V
IV
Iushchuk
N D
ND
Andreev
I V
IV
Shepeleva
G K
GK
Popova
T I
TI
D000293:Adolescent; D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D007107:Immune System / Q000382:microbiology / Q000473:pathology; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D019798:Neopterin / Q000097:blood*; D011379:Prognosis; D012008:Recurrence; D015009:Yersinia Infections / Q000175:diagnosis* / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000302:isolation & purification
D015850:Interleukin-6; D019798:Neopterin