title: [Successful coping and experience-dependent brain plasticity].
abstract: Recent progress in brain research has shown that the human brain, i.e., the neuronal and synaptic connectivity especially in higher cortical association centres, is much more plastic and use-dependent than previously thought. This contribution summarizes the present knowledge about this phenomenon of experience-dependent plasticity. Irritation, anxiety and the activation of the neuroendocrine stress-response-system is the most important trigger for the adaptive modification and reorganization of neuronal networks and synaptic connectivity. The experience and successful mastery of a large spectrum of different challenges already during early childhood and during later life diminish the risk of the acquisition and facilitation of maladaptive coping-strategies. Once established, the strongly facilitated neuronal networks involved in the generation of maladaptive behavioural patterns are difficult to reorganize. The experience of loss of control and the long-lasting activation of an uncontrollable stress response may contribute to the destabilization of the neuronal connectivity established in the course of acquisition of such maladaptive coping strategies.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Göttingen, Germany. ghuethe@gwdg.de
authors.forename: Gerald
authors.initials: G
authors.lastname: Hüther
mesh_terms: D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000818:Animals; D001007:Anxiety / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D003213:Conditioning, Psychological; D006801:Humans; D008016:Life Change Events; D008959:Models, Neurological; D008960:Models, Psychological; D009473:Neuronal Plasticity; D013312:Stress, Physiological / Q000503:physiopathology* / Q000523:psychology