Exchange of lipooligosaccharide synthesis genes creates potential Guillain-Barre syndrome-inducible strains of Campylobacter jejuni.
Human ganglioside-like structures, such as GM1, found on some Campylobacter jejuni strains have been linked to inducing the Guillain-Barré Syndrome (GBS). This study shows that a C. jejuni strain without GM1-like molecules acquired large DNA fragments, including lipooligosaccharide synthesis genes, from a strain expressing GM1-like molecules and consequently transformed into a number of potential GBS-inducible transformants, which exhibited a high degree of genetic and phenotypic diversity.
Phongsisay
Vongsavanh
V
Biotechnology and Environmental Biology, School of Applied Sciences, Bundoora, 3083, RMIT University, Melbourne, Victoria, Australia.
Perera
Viraj N
VN
Fry
Benjamin N
BN
D001426:Bacterial Proteins / Q000235:genetics*; D016123:Campylobacter jejuni / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005677:G(M1) Ganglioside / Q000378:metabolism; D022761:Gene Transfer, Horizontal; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D008070:Lipopolysaccharides / Q000096:biosynthesis*; D018716:Molecular Mimicry; D005810:Multigene Family; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D014169:Transformation, Bacterial
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides; D005677:G(M1) Ganglioside