Relationship between IL-10 and tumor markers in breast cancer patients.
Tumor markers are expressed due to molecular alterations of the tumor cells, and we can relate them to the immune system to find new associations to improve prognosis. IL-10 inhibits the generation of immune responses at the tumor site. To determine IL-10 expression in the tumor microenvironment and to associate it with certain tumor markers, 27 breast cancer patients were monitored by immunohistochemistry. The results showed that 23 breast cancer samples exhibited a strong expression of IL-10. IL-10 was associated with some poor prognosis tumor makers. A direct association between IL-10, Bcl-2, and Bax was detected. The relationship between IL-10 and Bax was statistically significant (P=0.001). An inverse association of IL-10 with p53 was observed. IL-10 reflects a suppressive tumor microenvironment, and its relationship with apoptosis markers can suggest an increase in the aggressiveness of the tumor even if it still is at an early stage.
Llanes-Fernández
Leticia
L
Instituto Nacional de Oncología y Radiobiología, 29 y F, Vedado, Ciudad de la Habana cp 10400, Cuba. llanesleticia@yahoo.com.mx
Alvarez-Goyanes
Rosa Irene
RI
Arango-Prado
Maria Del Carmen
Mdel C
Alcocer-González
Juan Manuel
JM
Mojarrieta
Julia Cruz
JC
Pérez
Xiomara Escobar
XE
López
Maiby Orozco
MO
Odio
Sonia Franco
SF
Camacho-Rodríguez
Rolando
R
Guerra-Yi
Marta Elena
ME
Madrid-Marina
Vicente
V
Tamez-Guerra
Reyes
R
Rodríguez-Padilla
Cristina
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000276:immunology; D018270:Carcinoma, Ductal, Breast / Q000097:blood; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood; D011960:Receptors, Estrogen / Q000097:blood; D016159:Tumor Suppressor Protein p53 / Q000097:blood
D014408:Biomarkers, Tumor; D016753:Interleukin-10; D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D016159:Tumor Suppressor Protein p53