title: Scleroderma and repeated spontaneous abortions treated with vitamin E--a case report--.
abstract: A 33-year-old woman was referred to our hospital due to repeated spontaneous abortions and positive autoantibodies. She had noticed Raynaud's phenomenon 13 years earlier. We diagnosed scleroderma based on the presence of Raynaud's phenomenon, proximal scleroderma, presence of anti-centromere antibodies, and histological findings on skin biopsy. Neither lupus anticoagulant nor anti-cardiolipin-beta2-glycoprotein 1 antibody was detected. We administered tocopherol nicotinate. Five months after the initiation of the treatment, she became pregnant and later delivered a healthy baby.
authors.affiliation: Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Harada
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kumemura
authors.forename: Riko
authors.initials: R
authors.lastname: Harada
authors.forename: Kan
authors.initials: K
authors.lastname: Komai
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D001324:Autoantigens / Q000097:blood; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D020733:RNA, Small Cytoplasmic / Q000097:blood; D012261:Ribonucleoproteins / Q000097:blood; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy*; D014810:Vitamin E / Q000627:therapeutic use*; D000099207:SS-A Antigen
chemical_list: D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D014810:Vitamin E; C116006:RO60 protein, human; D000099207:SS-A Antigen