Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three cases.
Cutaneous side effects from heparin administration are rare and usually located at injection sites. We report 3 cases of intraepidermal hemorrhagic blisters occurring distant from sites of subcutaneous injections of heparin. A causative link is suggested by a temporal relationship between heparin introduction and onset of disease as well as exclusion of other causes, but the mechanism remains unknown.
Perrinaud
Adeline
A
Department of Dermatology, Université François-Rabelais, University Hospital of Tours, Tours, France.
Jacobi
David
D
Machet
Marie-Christine
MC
Grodet
Claire
C
Gruel
Yves
Y
Machet
Laurent
L
D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
D000925:Anticoagulants; D006493:Heparin