Long-term expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus of the hypothalamus in response to an acute colonic inflammation.
This study examined the long-term effects of an acute colitis on central corticotropin-releasing factor (CRF) expression. An increase in CRF mRNA in the paraventricular nucleus of the hypothalamus (PVN) and the central nucleus of the amygdala (CeA) was observed during active colitis, and the effect in the PVN was maintained following recovery. In summary, hypothalamic gene expression of CRF persists in the PVN despite resolution of an acute colitis.
Greenwood-Van Meerveld
Beverley
B
Oklahoma Center for Neuroscience, Oklahoma University Health Sciences Center, Oklahoma City, 73104, USA. Beverley-Greenwood@ouhsc.edu
Johnson
Anthony C
AC
Schulkin
Jay
J
Myers
Dean A
DA
D000818:Animals; D001345:Autoradiography / Q000379:methods; D003092:Colitis / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology*; D003346:Corticotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D003952:Diagnostic Imaging / Q000379:methods; D024202:Electrophoretic Mobility Shift Assay / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism* / Q000503:physiopathology*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity
D016207:Cytokines; D014302:Trinitrobenzenesulfonic Acid; D003346:Corticotropin-Releasing Hormone; D009195:Peroxidase