title: A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia.
abstract: OBJECTIVE
  To perform genetic linkage analysis in a family affected with ALS and frontotemporal dementia (FTD).
  
  
  METHODS
  The authors performed a genome-wide linkage analysis of a four-generation, 50-member Scandinavian family in which five individuals were diagnosed with ALS and nine with FTD. Linkage calculations assuming autosomal dominant inheritance of a single neurodegenerative disease manifesting as either ALS or FTD with age-dependent penetrance were performed. Further analyses for ALS alone and FTD alone were performed. A parametric logarithm of odds (lod) score of 2.0 or greater was required for further study of a potential locus and crossover (haplotype) analysis.
  
  
  RESULTS
  A new ALS-FTD locus was identified between markers D9s1870 and D9s1791 on human chromosome 9p21.3-p13.3. A maximum multipoint lod score of 3.00 was obtained between markers D9s1121 and D9s2154. Crossover analysis indicates this region covers approximately 21.8 cM, or 14Mb.
  
  
  CONCLUSIONS
  A locus on chromosome 9p21.3-p13.3 is linked to ALS-FTD.
authors.affiliation: Day Neuromuscular Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
authors.forename: M
authors.initials: M
authors.lastname: Morita
authors.forename: A
authors.initials: A
authors.lastname: Al-Chalabi
authors.forename: P M
authors.initials: PM
authors.lastname: Andersen
authors.forename: B
authors.initials: B
authors.lastname: Hosler
authors.forename: P
authors.initials: P
authors.lastname: Sapp
authors.forename: E
authors.initials: E
authors.lastname: Englund
authors.forename: J E
authors.initials: JE
authors.lastname: Mitchell
authors.forename: J J
authors.initials: JJ
authors.lastname: Habgood
authors.forename: J
authors.initials: J
authors.lastname: de Belleroche
authors.forename: J
authors.initials: J
authors.lastname: Xi
authors.forename: W
authors.initials: W
authors.lastname: Jongjaroenprasert
authors.forename: H R
authors.initials: HR
authors.lastname: Horvitz
authors.forename: L-G
authors.initials: LG
authors.lastname: Gunnarsson
authors.forename: R H
authors.initials: RH
authors.lastname: Brown
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003704:Dementia / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D040641:Quantitative Trait Loci / Q000235:genetics*
chemical_list: D005819:Genetic Markers