On the utility of data from the International HapMap Project for Australian association studies.
We compare patterns of linkage disequilibrium (LD) for 633 SNPs in two regions between samples collected in two Australian states and HapMap samples collected from Utah residents of Northern and Western (NW) European ancestry (CEU). Patterns of LD in the Australian and HapMap samples are similar, and tag SNPs chosen using HapMap genotypes perform almost as well on Australian samples as tags chosen using Australian genotypes.
Stankovich
Jim
J
Division of Genetics and Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050 Parkville, Victoria, Australia. stankovich@wehi.edu.au
Cox
Charles J
CJ
Tan
Rachel B
RB
Montgomery
Douglas S
DS
Huxtable
Stewart J
SJ
Rubio
Justin P
JP
Ehm
Margaret G
MG
Johnson
Laura
L
Butzkueven
Helmut
H
Kilpatrick
Trevor J
TJ
Speed
Terence P
TP
Roses
Allen D
AD
Bahlo
Melanie
M
Foote
Simon J
SJ
D005060:Europe / Q000208:ethnology; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013648:Tasmania; D014589:Utah; D014739:Victoria