Does the proteome encode organellar pH?
Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the pI of proteins and the pH of organelles co-evolve to optimize function?
Brett
Christopher L
CL
Department of Physiology, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
Donowitz
Mark
M
Rao
Rajini
R
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015388:Organelles / Q000502:physiology*; D020543:Proteome / Q000502:physiology*
D020543:Proteome