Synaptic vesicles caught kissing again.
In this issue of Neuron, Harata et al. use a novel quenching technique to provide compelling evidence that kiss-and-run is the dominant mode of vesicle fusion at hippocampal synapses and that the prevalence of kiss-and-run can be modulated by stimulus frequency. The increased incidence of kiss-and-run at lower frequencies may ensure that vesicles are available for use during periods of high demand.
Sullivan
Jane M
JM
Department of Physiology and Biophysics, University of Washington School of Medicine, Box 357290, Seattle, Washington 98195, USA.
D004594:Electrophysiology; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D013572:Synaptic Vesicles / Q000502:physiology*
D018377:Neurotransmitter Agents