title: Effect of age-related chronic immobility on markers of bone turnover.
abstract: The effects of acute immobilization on bone turnover are well known, but the effects of chronic hypomobility with aging have not been studied. In a cohort of 1064 frail elderly subjects, immobility was significantly associated with serum PINP but not serum CTx after adjusting for confounders. The effect of immobility may be more marked on bone formation than on bone resorption.
  
  
  BACKGROUND
  Accelerated bone turnover and rapid bone loss caused by acute immobilization is well recognized, but the effects of age-related chronic reduction in mobility on bone turnover have been less well studied. We assessed the associations between bone turnover and measures of mobility in a cohort of elderly subjects.
  
  
  METHODS
  We measured serum levels of the aminoterminal propeptide of type I collagen (PINP), a marker of bone formation, and serum concentrations of the carboxyterminal telopeptide of type I collagen (CTx), a marker of bone resorption, as well as serum intact PTH, serum 25 hydroxyvitamin D (25OHD), mobility, and static balance in a well-characterized sample of 1064 elderly men and women living in residential aged care facilities. Serum creatinine, phosphate, albumin, and calcium were measured in a randomly selected subgroup of 447 subjects.
  
  
  RESULTS
  The subjects were elderly and frail; their mean age was 86.0 years (range, 65-101 years); 69% used a walking aid; and 77% were vitamin D deficient (serum 25OHD level < 39 nM). Both serum PINP and CTx increased with age in both sexes. Elevated PINP or CTx was significantly correlated with high PTH, creatinine, and albumin in both genders, except for albumin in women. Age- and gender-adjusted serum CTx and PINP were significantly higher in those with poorer mobility and those with worse static balance. In multivariate analyses, higher serum PINP but not CTx was associated with poorer mobility and worse static balance.
  
  
  CONCLUSIONS
  Our findings suggest that poor mobility contributes to the state of accelerated bone turnover usually seen in the elderly. The effect of chronic relative immobility may be more marked on bone formation than bone resorption.
authors.affiliation: Institute of Bone and Joint Research, University of Sydney, Sydney, Australia.
authors.forename: Jian Sheng
authors.initials: JS
authors.lastname: Chen
authors.forename: Ian D
authors.initials: ID
authors.lastname: Cameron
authors.forename: Robert G
authors.initials: RG
authors.lastname: Cumming
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Lord
authors.forename: Lyn M
authors.initials: LM
authors.lastname: March
authors.forename: Philip N
authors.initials: PN
authors.lastname: Sambrook
authors.forename: Judy M
authors.initials: JM
authors.lastname: Simpson
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Seibel
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000097:blood / Q000378:metabolism*; D008297:Male; D010012:Osteogenesis; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011347:Procollagen / Q000097:blood*
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; D003094:Collagen