[Neuropharmacological study of the joint action of verapamil and olanzapine on the content of neurotransmitters in Wistar rat brain structures].
The effects of jointly administered olanzapine and verapamil on the level of neurotransmitters and their metabolites in Wistar rat brain structures have been studied. Verapamil (i) produces a statistically significant decrease in dopamine and serotonin turnover increased by olanzapine injections and (ii) increases the norepinephrine content in all the brain structures studied.
Kudrin
V S
VS
Klodt
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PM
Gulieva
S T
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D000818:Animals; D001569:Benzodiazepines / Q000008:administration & dosage; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D008297:Male; D018377:Neurotransmitter Agents / Q000032:analysis* / Q000378:metabolism; D000077152:Olanzapine; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D014700:Verapamil / Q000008:administration & dosage*
D001569:Benzodiazepines; D002121:Calcium Channel Blockers; D018377:Neurotransmitter Agents; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors; D014700:Verapamil