A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273.
A novel ketone derivative of artemisinin, artemisitone-9, was produced by the biotransformation of cultured Streptomyces griseus ATCC 13273. The structure of the ketone product was fully elucidated by various spectroscopic techniques, and the mechanism of generating such novel metabolite is also discussed.
Liu
Ji-Hua
JH
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 210038, People's Republic of China.
Chen
You-Gen
YG
Yu
Bo-Yang
BY
Chen
Yi-Jun
YJ
D000890:Anti-Infective Agents / Q000378:metabolism*; D037621:Artemisinins / Q000737:chemistry / Q000378:metabolism*; D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013305:Streptomyces griseus / Q000378:metabolism*
D000890:Anti-Infective Agents; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin