title: Clinical observations on the use of the muscle relaxant rocuronium bromide in the dog.
abstract: This study was designed to evaluate the effectiveness of neuromuscular blockade with rocuronium bromide (rocuronium) in eighty dogs anaesthetised for a variety of surgical procedures. Rocuronium 0.3 or 0.6 mg/kg (G03 and G06) was administered intravenously (IV) and neuromuscular function was monitored with an acceleromyograph. Lag time (LT) was >1 min in both groups. Onset time (OT) was 2+/-0.9 and 1.1+/-0.6 min in the groups given 0.3 and 0.6 mg/kg, respectively. There was a significantly longer time of action with 0.6 mg/kg in contrast to 0.3 mg/kg rocuronium. Time of no response (TonR) was 9.1+/-4.9-16.9+/-6.1 min in the groups given 0.3 and 0.6 mg/kg, respectively. The time from the end of injection until 25% recovery of the first twitch from the baseline value (T1(25)) was 13.8+/-5.5 and 22.3+/-6.7 min in the groups given 0.3 and 0.6 mg/kg, respectively. T1(25-75) was similar in both groups. Total recovery to baseline values was achieved in 23.8+/-6.6 and 31.9+/-6.5 min in the groups given 0.3 and 0.6 mg/kg, respectively (P<0.05). Premedication, maintenance agent, body position and stimulation site had no significant influence on the pharmacodynamic parameters in both groups. It was concluded that rocuronium is an effective non-depolarising muscle relaxant in the dog under clinical conditions.
authors.affiliation: Clinic of Anaesthesiology and Perioperative Intensive Care, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria. Ulrike.auer@vu-wien.ac.at
authors.forename: Ulrike
authors.initials: U
authors.lastname: Auer
mesh_terms: D000732:Androstanols / Q000494:pharmacology*; D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D004283:Dog Diseases / Q000601:surgery; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009465:Neuromuscular Agents / Q000494:pharmacology*; D000077123:Rocuronium; D013997:Time Factors
chemical_list: D000732:Androstanols; D009465:Neuromuscular Agents; D000077123:Rocuronium