Effects of succinic acid derivatives on ex vivo acetylcholinesterase activity.
In the present study the acetylcholinesterase (AChE) inhibition and acute toxicity of two succinic acid derivatives were compared with tacrine. Administration of a single dose of each of two succinic acid derivatives produced a time and dose-dependent inhibition of brain AChE activity. Although the magnitude of the cholinergic effects observed with the two succinic acid derivatives was similar to that seen with tacrine and other AChE inhibitors, the toxicity study showed that the new inhibitors have less adverse side effects.
Espinosa Raya
J
J
Sección de Graduados y Departamento de Bioquímica, Escuela Superior de Medicina, Instituto Politécnico Nacional. Plan de San Luis y Díaz Mirón, México, DF, 11340 México, Mexico.
Correa-Basurto
J
J
Vázquez Alcántara
J I
JI
Trujillo-Ferrara
J G
JG
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D019802:Succinic Acid / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
D019802:Succinic Acid; D000110:Acetylcholinesterase