title: Congenital leukemia cutis with subsequent development of leukemia.
abstract: We describe a newborn infant who was born with a purpuric rash and subcutaneous nodules. Skin biopsies demonstrated acute myeloid leukemia. Cytogenetic studies revealed an 11q23 rearrangement. Initial bone marrow and cerebrospinal fluid examination did not demonstrate medullary or meningeal disease. Chemotherapy was initiated on the basis of the abnormal cytogenetic findings in the skin biopsy. Intensive chemotherapy was, given but the infant's leukemia progressed. The patient died of refractory leukemia and secondary fungal disease. This case report supports the observation that leukemia cutis with an 11q23 rearrangement should be treated aggressively.
authors.affiliation: Department of Pediatrics, University of California-San Francisco, California 94143-0519, USA.
authors.forename: Inga Hofmann
authors.initials: IH
authors.lastname: Zhang
authors.forename: Lee T
authors.initials: LT
authors.lastname: Zane
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Braun
authors.forename: John
authors.initials: J
authors.lastname: Maize
authors.forename: Seymour
authors.initials: S
authors.lastname: Zoger
authors.forename: Mignon L
authors.initials: ML
authors.lastname: Loh
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000151:congenital / Q000188:drug therapy / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents