title: The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in rats.
abstract: Behavioral effects of a hydroalcoholic (60% ethanol) extract from the leaves of Salvia elegans Vahl (Lamiaceae) were studied in male Sprague-Dawley rats. The extract was administered intraperitoneally and its effects on spontaneous motor activity (total motility, locomotion, rearing and grooming behavior) were monitored. Putative anxiolytic and antidepressant properties of Salvia elegans were studied in the elevated plus-maze test (EPM) and in the forced swimming test (FST), respectively. Deleterious effects of Salvia elegans on learning and memory were also studied by using active and passive avoidance paradigms. The results revealed that all doses (3.12, 12.5, 25 and 50 mg/kg) of the extract caused a significant decrease in total motility, locomotion, rearing and grooming behavior. Only the dose of 12.5 mg/kg increased the exploration of the EPM open arms in a similar way to that of diazepam (1 mg/kg). In the FST, all doses of the extract induced a reduction of immobility, in a similar way to that of fluoxetine (10 mg/kg) and imipramine (12.5 mg/kg), along with a significant increase in the time spent in swimming behavior. Acquisition of active avoidance responses was disrupted by pre-treatment with the extract, but retention of a passive avoidance response was not significantly modified. These results suggest that some of the components of the hydroalcoholic extract of Salvia elegans have psychotropic properties, which deserve further investigation.
authors.affiliation: Laboratorio de Farmacología del Comportamiento, Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile. smora@med.uchile.cl
authors.forename: S
authors.initials: S
authors.lastname: Mora
authors.forename: R
authors.initials: R
authors.lastname: Millán
authors.forename: H
authors.initials: H
authors.lastname: Lungenstrass
authors.forename: G
authors.initials: G
authors.lastname: Díaz-Véliz
authors.forename: J A
authors.initials: JA
authors.lastname: Morán
authors.forename: M
authors.initials: M
authors.lastname: Herrera-Ruiz
authors.forename: J
authors.initials: J
authors.lastname: Tortoriello
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027544:Salvia / Q000737:chemistry*; D013550:Swimming / Q000523:psychology
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010936:Plant Extracts