Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging.
Increased inflammatory activity is known to accompany aging. Single nucleotide polymorphisms of inflammatory mediator genes might therefore affect the aging process. Relation of eight SNPs (tumor necrosis factor-alpha [TNF-alpha] -1031 T/C, interleukin-10 [IL-10] -819 T/C, IL-1beta -511 C/T, IL-6 -634 C/G, IL-18 -607 A/C, transforming growth factor-beta [TGF-beta] +869 C/T, matrix metalloproteinase-1 [MMP-1] -1607 1G/2G, and MMP-3 -1171 5A/6A) with age or gender was evaluated in 500 Japanese persons (mean age: 56.7 years old, range: 19-100) by the chi-square test. There was a significant association of IL-10 -819 T/C with age (p =.0026). The association remained significant after multivariate logistic regression analysis (odds ratio for an age interval for 1 year, 1.009; 95% CI, 1.002-1.016). Furthermore, the genotype distribution of IL-10 -819 T/C was completely consistent with that of -592 A/C. These data suggest that IL-10 -819 T/C and -592 A/C may be a promising candidate for an aging-related gene in a Japanese population.
Okayama
Naoko
N
Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan.
Hamanaka
Yuichiro
Y
Suehiro
Yutaka
Y
Hasui
Yoshinori
Y
Nakamura
Junji
J
Hinoda
Yuji
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D016207:Cytokines; D016753:Interleukin-10; D019278:Matrix Metalloproteinase 3