The evolutionary rate of a protein is influenced by features of the interacting partners.
Rates of protein evolution are thought to be influenced by features of protein-protein interaction (PPI). However, the most important features of interaction for determining the evolutionary rate are poorly understood. Here, we consider four categories for PPIs in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function or different function (DF) and the extent to which these interactions involve connections in the dense part or sparse part (SP) of a PPI network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.
Makino
Takashi
T
Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Yata, Mishima, Japan.
Gojobori
Takashi
T
D016000:Cluster Analysis; D019143:Evolution, Molecular; D008954:Models, Biological; D008956:Models, Chemical; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000145:classification* / Q000235:genetics / Q000502:physiology*
D029701:Saccharomyces cerevisiae Proteins