An investigation into the behaviour of the electrolytes in presence of ionic urfactants.
The effect of various concentrations of Sodium Chloride and Lithium Sulphate in presence of Carbonate-bicarbonate buffer at pH 9.20 on the base-catalyzed hydrolysis of procaine was investigated. The whole study was done in the presence of different concentration of cetyltrimethyl ammonium bromide (CTAB) and Sodium dodecyl Sulphate (SDS) at 60 degrees C. Addition of different electrolytes suppressed the maxima in the Surfactant Effect Ratio (SER). The presence of these additives increase the inhibitory effect with a corresponding in their concentrations SDS/SO4, appeared to be most effective inhibitory amongst SDS/Li2SO4, SDS/NaCl, CTAB/Li2SO4, and CTAB/NaCl systems.
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Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
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