title: Ratio of inhaled corticosteroid to bronchodilator treatment and asthma hospitalisation.
abstract: BACKGROUND
  Previous research based on aggregated data has led to conflicting interpretations of the relationship between the corticosteroid:bronchodilator (C:B) ratio and outcome measures.
  
  
  OBJECTIVE
  To assess whether the C:B ratio is associated with hospital contact for asthma at individual patient level.
  
  
  METHODS
  The study was a retrospective multivariate analysis, using data from the U.K. General Practice Research Database from 1993 to 1996. The subjects were 3465 asthma-diagnosed patients receiving bronchodilator and corticosteroid medication. The main outcome measures were asthma-related hospital contacts.
  
  
  RESULTS
  There was an inverse association between the C:B ratio and hospital contact after controlling for age. The odds ratio for the C:B ratio was 0.87 (95 % CI 0.73-0.98) and 1.04 (95% CI 1.01-1.07) for five-year agebands among patients aged five years and over. There was no systematic relationship between the C:B ratio and hospital contacts for patients aged under five years.
  
  
  CONCLUSIONS
  The results of this study show that higher C:B ratios are associated with lower levels of hospital contacts at patient level, although there are exceptions possibly linked to disease severity. For patients under five years, the ratio may not be a good outcome measure, perhaps owing to the difficulty in diagnosing asthma or poor compliance.
authors.affiliation: Department of Medicines Management, Keele University, Keele, Staffordshire ST5 5BG, England. m.frischer@keele.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Frischer
authors.forename: H
authors.initials: H
authors.lastname: Heatlie
authors.forename: S
authors.initials: S
authors.lastname: Chapman
authors.forename: J
authors.initials: J
authors.lastname: Bashford
authors.forename: J
authors.initials: J
authors.lastname: Norwood
authors.forename: D
authors.initials: D
authors.lastname: Millson
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D019992:Databases as Topic; D004359:Drug Therapy, Combination; D004739:England; D005194:Family Practice; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents