Effects of diazepam and cinchocaine on biogenic amines.
Neurochemical and behavioural research show that benzodiazepines are well know anxiolytic drugs, which are also used for the treatment of epilepsy, hypnosis and insomnia. Administration of benzodiazepine to experimental animals produces anxiolytic-like effects in various animal and decreases exploratory activity. Psychomotor stimulants such as cinchocaine also showed potent effect on brain biogenic amines and their metabolite. The present studies indicate the changes in dopamine and 5-HT and their metabolites levels after acute administration of cinchocaine and diazepam.
Afroz
S
S
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Ahmed
S P
SP
Haider
S
S
Haleem
D J
DJ