Effect of diethylsulfoxide on the thermal denaturation of DNA.
DNA thermal denaturation has been investigated in aqueous solutions of diethylsulfoxide (DESO) by means of UV-vis and densimetry methods. It is suggested that, on the one hand, the structural change of entire solutions and, on the other hand, a direct interaction of DESO with DNA are responsible for the observed peculiar behavior. The results obtained were compared with those of dimethylsulfoxide (DMSO), also known from literature.
Markarian
Shiraz A
SA
Department of Chemistry, Yerevan State University, 375049 Yerevan, Armenia. shmarkar@ysu.am
Asatryan
Arpine M
AM
Grigoryan
Karine R
KR
Sargsyan
Hasmik R
HR
D000818:Animals; D002417:Cattle; D004247:DNA; D003720:Densitometry; D004121:Dimethyl Sulfoxide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006358:Hot Temperature; D009691:Nucleic Acid Denaturation; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013454:Sulfoxides / Q000494:pharmacology; D013950:Thymus Gland / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D012996:Solutions; D013454:Sulfoxides; C454662:diethyl sulfoxide; D014867:Water; D004247:DNA; D004121:Dimethyl Sulfoxide