title: Determination of astemizole by a spectrophotometric charge- transfer method.
abstract: Iodine-astemizole charge-transfer complex has been utilized for the assay of astemizole. The complex formed in the proposed method shows strong absorption at 360 nm with a corresponding molar absorptivity. epsilon of 3.26 x 10 L mol1 cm-1 and obeyance of Beer's law over the concentration range 2-12 pg/mi. When the proposed method was applied to commercial tablets labeled to contain 10 mg of active ingredient per tablet, the mean percentage found was 99.72 +/- 1.36. Analysis of variance, (ANO VA), and added recovery experiments indicated adequate precision and accuracy for the method.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh-11451, Saudi Arabia.
authors.forename: O A
authors.initials: OA
authors.lastname: Al-Deeb
authors.forename: H A
authors.initials: HA
authors.lastname: Al-Khamees
authors.forename: M E
authors.initials: ME
authors.lastname: Hagga
authors.forename: M E
authors.initials: ME
authors.lastname: Al-Awady