title: Development of severe thyroid-associated ophthalmopathy in a patient with disseminated thyroid cancer treated with recombinant human thyrotropin/radioiodine and retinoic acid.
abstract: We present a case in which a patient with disseminated well-differentiated papillary thyroid cancer developed severe thyroid-associated ophthalmopathy. Eight years after initial surgery and ablative radioiodine therapy the patient was found to have multiple pulmonary metastases. The metastases showed poor uptake of radioiodine. An attempt was made to use 13-cis-retinoic acid in order to achieve a redifferentiation of the thyroid cancer cells before recombinant human thyrotropin (rhTSH) stimulated radioiodine therapy. The treatment did not improve the uptake of radioiodine. However, approximately 2 weeks after completion of the treatment the patient experienced discomfort in her eyes and then over the next months she developed a severe ophthalmopathy. The analyses of TSH receptor antibodies and S-thyroglobulin simultaneously showed a pronounced increase. An association between therapy given and severe ophthalmopathy cannot be excluded.
authors.affiliation: Department of Oncology, Sahlgrenska University Hospital, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. gertrud.berg@oncology.gu.se
authors.forename: Gertrud
authors.initials: G
authors.lastname: Berg
authors.forename: Tommy
authors.initials: T
authors.lastname: Andersson
authors.forename: Lena
authors.initials: L
authors.lastname: Sjödell
authors.forename: Svante
authors.initials: S
authors.lastname: Jansson
authors.forename: Ernst
authors.initials: E
authors.lastname: Nyström
mesh_terms: D000368:Aged; D005260:Female; D049970:Graves Ophthalmopathy / Q000209:etiology*; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000009:adverse effects; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000150:complications* / Q000628:therapy; D013965:Thyroidectomy; D013972:Thyrotropin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin; D013954:Thyroglobulin; D015474:Isotretinoin