title: A binocular pupil model for simulation of relative afferent pupil defects and the swinging flashlight test.
abstract: Many important intracranial neural pathways are involved in the control of the two muscles of the human pupil and the observation and analysis of pupil responses to light or other stimuli is of great interest in many clinical procedures. The binocular pupil model presented in this document has a topology encompassing much of the complexity of the pupil system neurophysiology. The dynamic parameters of the model were matched against pupil experiments under multiple conditions. It is employed here to simulate responses to the swinging flashlight test, a procedure which is routinely practiced in ophthalmology to diagnose different degrees of relative afferent pupil defects often a consequence of severe optic nerve diseases or retinal dysfunctions. Other, not light-dependent, pupil stimuli are briefly discussed.
authors.affiliation: Neuroptics Research Laboratory, 2826 Telegraph Ave., Berkeley, CA 94705, USA. claudio@neuroptics.com
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Privitera
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Stark
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D017711:Nonlinear Dynamics; D010775:Photic Stimulation; D011680:Pupil / Q000502:physiology*; D011681:Pupil Disorders / Q000503:physiopathology*; D015348:Vision, Binocular / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology