Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo.
Reactivation potency of three newly developed oximes K027, K033 and K048 was tested using standard in vitro and in vivo reactivation tests. K027 and K048 seem to be efficacious reactivators of tabun-inhibited acetylcholinesterase. K033 is sufficient reactivator of cyclosarin-inhibited AChE. However, its potency is poor compared with current "gold standard" oxime HI-6.
Kuca
Kamil
K
Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.
Bartosova
Lucie
L
Kassa
Jiri
J
Cabal
Jiri
J
Bajgar
Jiri
J
Kunesova
Gabriela
G
Jun
Daniel
D
D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D004789:Enzyme Activation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology*; D009498:Neurotoxins / Q000494:pharmacology* / Q000633:toxicity; D010091:Oximes / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D009498:Neurotoxins; D010091:Oximes; D000110:Acetylcholinesterase