title: Evaluating and defining the sharpness of intraocular lenses: part 1: Influence of optic design on the growth of the lens epithelial cells in vitro.
abstract: OBJECTIVE
  To develop a new method for the evaluation of the optic edge design of intraocular lenses (IOLs).
  
  
  METHODS
  Charité Humboldt University and Berlin Eye Research Institute (Beri), Berlin, Germany.
  
  
  METHODS
  Poly(methyl methacrylate) IOLs with 11 edge designs were manufactured. Each lens design was evaluated using EPCO 2000. Also, edge's ability to stop cell growth was observed by placing each IOL into cell culture and observing cell growth over 18 days on average.
  
  
  RESULTS
  Only 3 groups, those with the sharpest edge design, prevented the growth of lens epithelial cells onto the visual axis of the lens. The edge design that effectively stopped cell growth was characterized by an area above the edge of 13.5 microm2 at the most.
  
  
  CONCLUSIONS
  Results shows that the edge design of IOLs plays an important role in the prevention of posterior capsule opacification. A specific optic edge design was most effective in this prevention.
authors.affiliation: Berlin Eye Research Institute (Beri), Berlin, Germany. mntetz@aol.com
authors.forename: Manfred
authors.initials: M
authors.lastname: Tetz
authors.forename: Anne
authors.initials: A
authors.lastname: Wildeck
mesh_terms: D000818:Animals; D002386:Cataract / Q000517:prevention & control; D002417:Cattle; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000502:physiology*; D007903:Lens Capsule, Crystalline / Q000473:pathology; D007908:Lens, Crystalline / Q000254:growth & development*; D007910:Lenses, Intraocular; D008854:Microscopy, Electron; D011183:Postoperative Complications / Q000517:prevention & control; D011474:Prosthesis Design