One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water.
Selenocysteine containing peptoids and peptide-peptoid conjugates were synthesized by combinatorial Ugi-MCRs (multicomponent reactions) in water: for the first time, an acetal (selenoacetal 2a) was used in Ugi-MCR to furnish selenocysteine peptoids in one step as model compounds for selenocysteine peptides and proteins.
Abbas
Muhammad
M
Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.
Bethke
John
J
Wessjohann
Ludger A
LA
D000080:Acetals / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008956:Models, Chemical; D019151:Peptide Library; D034444:Peptoids / Q000138:chemical synthesis*; D017279:Selenocysteine / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
D000080:Acetals; D006571:Heterocyclic Compounds; D019151:Peptide Library; D034444:Peptoids; D014867:Water; D017279:Selenocysteine