CD45: all is not yet crystal clear.
CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the biology of the first recognized receptor tyrosine phosphatase, CD45, is reviewed.
Holmes
Nick
N
Division of Immunology, Department of Pathology, Cambridge University, UK. nh106@cam.ac.uk
D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D017493:Leukocyte Common Antigens / Q000235:genetics / Q000502:physiology*; D011110:Polymorphism, Genetic; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology
D007527:Isoenzymes; D017493:Leukocyte Common Antigens