title: Multiple bone fractures found in a young sarcoidosis patient with long stable disease.
abstract: A 22-year-old Japanese man was found to have bilateral hilar lymphadenopathy (BHL), and was diagnosed with sarcoidosis in 1995. He was followed without treatment until 2002, when a bone fracture due to osseous sarcoidosis was found in his left thumb. Despite systemic treatment with corticosteroid and methotrexate, a new bone lesion developed in his right foot and his right middle finger was fractured. The patient also suffered multiple organ involvements including brain and muscle lesions. This is the first report of a sarcoidosis patient who presented with BHL, and developed bone fractures after a long stable period of more than 5 years.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, and Department of Internal Medicine, Chitose City Hospital, Hokkaido, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Handa
authors.forename: Sonoko
authors.initials: S
authors.lastname: Nagai
authors.forename: Isao
authors.initials: I
authors.lastname: Ito
authors.forename: Michio
authors.initials: M
authors.lastname: Shigematsu
authors.forename: Kunio
authors.initials: K
authors.lastname: Hamada
authors.forename: Masanori
authors.initials: M
authors.lastname: Kitaichi
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ohta
authors.forename: Takateru
authors.initials: T
authors.lastname: Izumi
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005383:Finger Injuries / Q000175:diagnosis / Q000209:etiology*; D005500:Follow-Up Studies; D018409:Foot Injuries / Q000175:diagnosis / Q000209:etiology*; D050723:Fractures, Bone / Q000175:diagnosis / Q000209:etiology*; D005598:Fractures, Spontaneous; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents