A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions.
A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show antiproliferative activities similar to discodermolide.
Shaw
Simon J
SJ
Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA. shaw@kosan.com
Sundermann
Kurt F
KF
Burlingame
Mark A
MA
Zhang
Dan
D
Petryka
Joseph
J
Myles
David C
DC
D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
D007783:Lactones; D014315:Triterpenes; C478086:23,24-dihydrocucurbitacin B