title: Influence of steroid drugs on orthodontically induced root resorption.
abstract: OBJECTIVE
  To investigate the effect of acute and chronic corticosteroid treatment on orthodontically induced root resorption.
  
  
  METHODS
  'Split mouth' design performing orthodontic tooth movement in 64, 6-month-old male rats divided into three groups: acute (n = 22), chronic (n = 23) and control group (n = 19). Acute and chronic group received corticosteroid treatment (8 mg/kg/day) for 3 and 7 weeks, respectively, while no pharmacological treatment was performed in the control group. Performed at the Department of Orthodontics, School of Dentistry, University of Aarhus, Aarhus, Denmark.
  
  
  METHODS
  The upper left first molar was moved mesially for 21 days in all three groups with 25 g of force. Undecalcified histological sections were cut at the coronal and apical level.
  
  
  METHODS
  The number of intersections hitting resorption lacunae (ES), defined as a scalloped surface with or without cementoclasts, over the total number of intersections hitting the root surface (RS) were recorded and expressed as percentage.
  
  
  RESULTS
  The acute group showed significantly more root resorption at the mesio-coronal level compared with the control and the chronic group.
  
  
  CONCLUSIONS
  This could be ascribed to the lack of balance between blastic activities (inhibited by the drug) and the clastic activities (enhanced or unchanged by drug administration) occurring in the initial phase of drug administration. As a consequence, a careful monitoring of patients undergoing acute corticosteroid treatment is suggested.
authors.affiliation: Department of Orthodontics, School of Dentistry, Aarhus University, Aarhus, Denmark. cverna@odont.au.dk
authors.forename: C
authors.initials: C
authors.lastname: Verna
authors.forename: L E
authors.initials: LE
authors.lastname: Hartig
authors.forename: S
authors.initials: S
authors.lastname: Kalia
authors.forename: B
authors.initials: B
authors.lastname: Melsen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D009969:Orthodontic Wires; D010010:Osteoclasts / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D019227:Tooth Apex / Q000187:drug effects / Q000473:pathology; D014087:Tooth Movement Techniques / Q000009:adverse effects* / Q000295:instrumentation; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D008775:Methylprednisolone