Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells.
The low density lipoprotein receptor-related protein 4 gene (Lrp4) was identified by subtractive screening of cDNAs of the migratory primordial germ cells (PGCs) of E8.5-9.5 embryo and E3.5 blastocysts. Lrp4 is expressed in PGCs in the hindgut and the dorsal mesentery of E9.5 embryos, and in germ cells in the genital ridges of male and female E10.5-13.5 embryos. Lrp4 is also expressed in spermatogonia of the neonatal and adult testes and in the immature oocytes and follicular cells of the adult ovary. The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells.
Yamaguchi
Yasuka L
YL
Department of Molecular Embryology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan.
Tanaka
Satomi S
SS
Kasa
Miyuki
M
Yasuda
Kunio
K
Tam
Patrick P L
PP
Matsui
Yasuhisa
Y
D000595:Amino Acid Sequence; D000818:Animals; D002465:Cell Movement; D018076:DNA, Complementary / Q000302:isolation & purification; D005260:Female; D040461:Gene Components; D005854:Germ Cells / Q000378:metabolism*; D006066:Gonads / Q000196:embryology / Q000378:metabolism; D026502:LDL-Receptor Related Proteins; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D039902:Multipotent Stem Cells / Q000378:metabolism; D011973:Receptors, LDL / Q000235:genetics*; D014018:Tissue Distribution
D018076:DNA, Complementary; D026502:LDL-Receptor Related Proteins; C116415:Lrp4 protein, mouse; D011973:Receptors, LDL