Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection.
Immunizations early in life, when the host is most susceptible to infection, allow protective immunological memory to develop. Decreasing the dose of Cas-Br-E murine leukemia virus when priming neonatal mice results in adult-like, Type 1 protective responses, but the resulting memory cell populations are smaller than after adult priming. After secondary challenge, virus-specific CD8+ memory cell populations expand twice as much in neonate-primed mice as in adult-primed mice. We found that when equivalent numbers of virus-specific cells were transferred into virus-susceptible mice, protection from disease was similar whether donor, immune mice were primed as neonates or adults, and IL-4 did not alter in vivo virus-specific CD8+ memory cell effector function. Hence, neonate-primed CD8+ cells develop into memory cells that rival adult-primed cells in proliferation and effector function.
Fadel
Shaza A
SA
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Cowell
Lindsay G
LG
Cao
Shui
S
Ozaki
Daniel A
DA
Kepler
Thomas B
TB
Steeber
Douglas A
DA
Sarzotti
Marcella
M
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D003602:Cytotoxicity, Immunologic; D007111:Immunity, Cellular; D007117:Immunization, Secondary; D007156:Immunologic Memory; D015847:Interleukin-4 / Q000502:physiology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D012192:Retroviridae Infections / Q000276:immunology / Q000517:prevention & control; D014412:Tumor Virus Infections / Q000276:immunology / Q000517:prevention & control
D000914:Antibodies, Viral; D000956:Antigens, Viral; D015847:Interleukin-4