The AP-1/CJUN signaling cascade is involved in muscle differentiation: implications in muscle wasting during cancer cachexia.
The aim of the present study was to investigate a possible role of the AP-1 signaling cascade in the process of wasting associated with cancer cachexia at the level of skeletal muscle. The injection of virus containing the TAM67 protein (a blocker of the AP-1 protein) to the gastrocnemius muscle of tumour-bearing rats resulted in a significant recovery of the muscle mass (which is dramatically reduced as a result of tumour burden), therefore suggesting that AP-1 is certainly involved in the signaling associated with muscle protein accretion. In conclusion, the gene therapy approach presented here clearly suggests an important role for AP-1 in muscle signaling during catabolic states.
Moore-Carrasco
Rodrigo
R
Departament de Bioquímica i Biologia Molecular, Cancer Research Group, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain.
García-Martínez
Celia
C
Busquets
Sílvia
S
Ametller
Elisabet
E
Barreiro
Esther
E
López-Soriano
Francisco J
FJ
Argilés
Josep M
JM
D000818:Animals; D002100:Cachexia / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D015316:Genetic Therapy; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000378:metabolism / Q000473:pathology; D009133:Muscular Atrophy / Q000378:metabolism / Q000473:pathology; D017570:MyoD Protein / Q000378:metabolism; D018995:Myosin Heavy Chains / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D018808:Transcription Factor AP-1 / Q000378:metabolism*; D019282:Wasting Syndrome
D017570:MyoD Protein; D010446:Peptide Fragments; D016755:Proto-Oncogene Proteins c-jun; D011993:Recombinant Fusion Proteins; C439528:TAM67 peptide; D018808:Transcription Factor AP-1; D018995:Myosin Heavy Chains