title: Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly.
abstract: Splenic volume and Helicobacter pylori (H. pylori) infection were evaluated in 67 patients with chronic idiopathic neutropenia (CIN) and 39 healthy individuals. Using ultrasound, splenomegaly was found in 61.7% of H. pylori-infected subjects compared to only 8.7% noted in the group of H. pylori-non-infected individuals (P < 0.0001). Splenomegaly was also found in 47.8% of CIN patients compared to 12.8% in the group of non-CIN subjects (P = 0.0003). However, applying the two-way ANOVA test, a statistically significant effect on splenic volume was documented for "factor H. pylori " (F1(102) = 16.800, P < 0.0001) but not for "factor CIN" (F1(102) = 3.213, P = 0.0760), suggesting that CIN-associated splenomegaly is probably due to H. pylori infection.
authors.affiliation: Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece. epapadak@med.uoc.gr
authors.forename: Helen A
authors.initials: HA
authors.lastname: Papadaki
authors.forename: Charis
authors.initials: C
authors.lastname: Pontikoglou
authors.forename: Dimitris G
authors.initials: DG
authors.lastname: Eliopoulos
authors.forename: Katerina
authors.initials: K
authors.lastname: Pyrovolaki
authors.forename: Rania
authors.initials: R
authors.lastname: Spyridaki
authors.forename: George D
authors.initials: GD
authors.lastname: Eliopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002908:Chronic Disease; D005260:Female; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000209:etiology*; D014463:Ultrasonography