title: Novel modes of splicing repression by PTB.
abstract: Polypyrimidine-tract-binding protein (PTB) is a repressive regulator of alternative splicing. Models for PTB activity have ranged from simple binding competition with splicing factor U2AF(65) at regulated polypyrimidine tracts to looping out of repressed exons by binding of PTB to flanking sites. Structural analysis of PTB bound to RNA suggests how PTB monomers can induce loops, but two recent publications indicate that repression by PTB involves more than just binding to RNA.
authors.affiliation: Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Spellman
authors.forename: Christopher W J
authors.initials: CW
authors.lastname: Smith
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D016391:Genes, src / Q000235:genetics; D008957:Models, Genetic; D038941:Polypyrimidine Tract-Binding Protein / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D019014:fas Receptor / Q000235:genetics
chemical_list: D019014:fas Receptor; D038941:Polypyrimidine Tract-Binding Protein; D012313:RNA