Prothrombin overload causes thromboembolic complications in prothrombin complex concentrates: in vitro and in vivo evidence.
Grundman
Claudia
C
Plesker
Roland
R
Kusch
Manuela
M
Hanschmann
Kay Martin
KM
Eich
Stefanie
S
Seitz
Rainer
R
König
Herbert
H
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000009:adverse effects* / Q000737:chemistry; D015949:Factor IXa / Q000008:administration & dosage / Q000494:pharmacology; D002836:Hemophilia B / Q000188:drug therapy; D066298:In Vitro Techniques; D011516:Prothrombin / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits; D013923:Thromboembolism / Q000209:etiology*
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D011516:Prothrombin; D015949:Factor IXa