Studies on griseofulvin: part-ii effects on the liver and kidney of albino rat.
Studies were performed on albino rats to investigate any untoward effects of griseofulvin on their liver and kidneys. Animals weighing between 200-250g were selected and divided into control and test groups. Griseofulvin was administered to the test groups at a dose level of 20 mg/Kg/day for 2, 46 and 8 weeks respectively. Animals wee sacrificed at the end of their respective study periods for collection of blood and removal of the liver and kidneys. Histopathological examination of the liver and kidneys of the treated animals at the end of 4 and 8 weeks of griseofulvin administration showed no cytotoxic changes. It was, therefore, concluded that griseofulvin has no hepatotoxic effects in albino rats at a dose level of 20 mg/Kg/day.
Shamim
S M
SM
Department of Pharmacology, University of Karachi, Karachi-75270.
Mirza
M
M
Ahmad
Z
Z
Khalid
Q
Q
Qureshi
S A
SA
Ahmad
S I
SI