17Beta-hydroxysteroid dehydrogenases in human endometrium and its disorders.
In situ estrogen metabolism and synthesis have been considered to play a very important role in the development and progression of human endometrial carcinoma. 17Beta-hydroxysteroid dehydrogenases (17-HSDs) are enzymes involved in the formation of active sex steroids, including testosterone, estrone (E1) and estradiol (E2). Estrogens are interchanged by two enzymes, 17-HSD types 1 and 2, type 1 converts E1 to E2, and type 2 does reverse actions. 17-HSD type 5 catalyzes the reduction of androstenedione to testosterone. 17-HSD type 2 expression was decreased through normal endometrium, hyperplasia and carcinoma accordingly. There was a significant inverse correlation between intratumoral E2 concentration and the level of 17-HSD type 2 mRNA in endometrial carcinoma. 17-HSD type 5 expression was significantly increased through normal endometrium, hyperplasia and carcinoma accordingly. These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma.
Ito
Kiyoshi
K
Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Utsunomiya
Hiroki
H
Suzuki
Takashi
T
Saitou
Sumika
S
Akahira
Jun-Ichi
J
Okamura
Kunihiro
K
Yaegashi
Nobuo
N
Sasano
Hironobu
H
D015067:17-Hydroxysteroid Dehydrogenases / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000201:enzymology; D002277:Carcinoma / Q000201:enzymology* / Q000235:genetics; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000235:genetics; D004717:Endometrium / Q000201:enzymology*; D004967:Estrogens / Q000096:biosynthesis / Q000378:metabolism*; D005260:Female; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism
D004967:Estrogens; D012333:RNA, Messenger; D015067:17-Hydroxysteroid Dehydrogenases