Lentiviral vectors for use in the central nervous system.
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vectors, and the application of siRNA's using lentiviral vectors. We also describe some of the features that make lentiviral vectors a likely candidate for human gene therapy in the brain.
Jakobsson
Johan
J
Department of Experimental Medical Research, CNS Gene Therapy Unit, Section for Neuroscience, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden. johan.jakobsson@med.lu.se
Lundberg
Cecilia
C
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism*; D005822:Genetic Vectors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D016086:Lentivirus; D009422:Nervous System Diseases / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D052416:Targeted Gene Repair / Q000379:methods* / Q000639:trends*