Sampling the antibiotic resistome.
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.
D'Costa
Vanessa M
VM
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada, L8N 3Z5.
McGrann
Katherine M
KM
Hughes
Donald W
DW
Wright
Gerard D
GD
D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D017576:Daptomycin / Q000378:metabolism / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004917:Erythromycin / Q000378:metabolism / Q000494:pharmacology; D005798:Genes, Bacterial; D048628:Ketolides / Q000378:metabolism / Q000494:pharmacology; D018942:Macrolides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D012293:Rifampin / Q000378:metabolism / Q000494:pharmacology; D012988:Soil Microbiology; D013302:Streptomyces / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D014296:Trimethoprim Resistance; D020713:Vancomycin Resistance / Q000235:genetics; D014769:Virginiamycin / Q000378:metabolism / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D002939:Ciprofloxacin; D004917:Erythromycin; C106791:telithromycin; D017576:Daptomycin; D012293:Rifampin