title: Analgesic and disease modifying effects of interferential current in psoriatic arthritis.
abstract: Interferential current (IFC) was suggested to improve the skin manifestations of psoriasis vulgaris, possibly by enhancing the intracellular concentration of cyclic AMP. We assessed the efficacy of IFC on psoriatic arthritis (PsA). Nine consecutive patients were analyzed at baseline and after 16 weeks of IFC therapy. Bipolar IFC was applied twice daily to hands, feet plus all affected joints. IFC improved SF-36 assessed body pain, but not other SF-36 subscales. Morning stiffness, tender joint counts, and physician assessed disease activity improved. In contrast, visual analogue scale assessed pain, CRP and ESR measurements were unchanged. MRI of the most affected hand or foot documented a tendency towards worsened tendinitis, soft tissue swelling, and new joint space narrowing and erosions. Bone scintigraphy showed a trend towards deterioration. New joints became inflamed within treated sites. Thus IFC has analgesic effects in PsA, but does not have a satisfactory disease modifying effect.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Albert-Ludwigs University, Medizinische Universitätsklinik, Hugstetterstr. 55, 79106 Freiburg, Germany. ulrich.walker@klinikum.uni-freiburg.de
authors.forename: U A
authors.initials: UA
authors.lastname: Walker
authors.forename: M
authors.initials: M
authors.lastname: Uhl
authors.forename: S M
authors.initials: SM
authors.lastname: Weiner
authors.forename: K
authors.initials: K
authors.lastname: Warnatz
authors.forename: A
authors.initials: A
authors.lastname: Lange-Nolde
authors.forename: H
authors.initials: H
authors.lastname: Dertinger
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
authors.forename: S A
authors.initials: SA
authors.lastname: Jurenz
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010865:Pilot Projects; D011859:Radiography; D013997:Time Factors; D004561:Transcutaneous Electric Nerve Stimulation / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D018501:Antirheumatic Agents; D003287:Contrast Media; D019786:Gadolinium DTPA