BiP regulates autoimmune inflammation and tissue damage.
The endoplasmic reticulum chaperone BiP, in addition to its many important intracellular functions, has anti-inflammatory and immunomodulatory properties when present in the extracellular environment by the stimulation of an anti-inflammatory gene programme from human monocytes and by the development of T-cells that secrete regulatory cytokines such as interleukin-10 and interleukin-4. It can both prevent as well as treat ongoing collagen-induced arthritis. It is, therefore, a potential new biologic therapy for rheumatoid arthritis.
Panayi
G S
GS
GKT School of Medicine, King's College London, Department of Academic Rheumatology, Guy's Hospital, London SE1 9RT, United Kingdom. gabriel.panayi@kcl.ac.uk
Corrigall
V M
VM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000517:prevention & control; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D007249:Inflammation / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism / Q000502:physiology*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; D007155:Immunologic Factors; D018832:Molecular Chaperones; D016753:Interleukin-10; D015847:Interleukin-4