title: Outcomes of bupropion therapy for smoking cessation during routine clinical use.
abstract: BACKGROUND
  Knowledge pertaining to the effectiveness of smoking cessation treatments and patient characteristics that may affect success may enable smokers and clinicians to select individualized treatment for each patient and ultimately increase the success rate of smoking cessation in general.
  
  
  OBJECTIVE
  To evaluate the effectiveness of bupropion as a smoking cessation agent when used in routine clinical practice.
  
  
  METHODS
  This was a prospective, observational study with a one year follow-up period. Adult smokers presenting to community pharmacies in British Columbia, Canada, with an index prescription for bupropion for smoking cessation (N = 205) were eligible. The primary outcome was the biochemically validated 12 month point abstinence (PA) rate from smoking. Secondary outcomes included the frequency of adverse events, patterns of bupropion use in routine clinical practice, and possible predictors of bupropion effectiveness.
  
  
  RESULTS
  The validated 12 month PA rate was 21.0%. Of subjects who reported taking at least one dose of bupropion, 70.4% (126/179) experienced at least one adverse event and 29.6% (53/179) reported stopping the drug due to adverse effects. Greater length of time on bupropion (OR 0.98) and a lower cigarette pack-year history (OR 1.05) were associated with an increase in the odds of smoking cessation.
  
  
  CONCLUSIONS
  Subjects receiving bupropion in a real-life setting exhibited a similar abstinence rate at 12 months as has been observed in the active drug groups of placebo-controlled clinical trials. However, the patterns of use and discontinuation rate due to adverse events differed substantially from those observed in early efficacy studies.
authors.affiliation: Research and Performance Support, Regina Qu'Appelle Health Region, Regina, Saskatchewan, Canada. elan.paluck@rqhealth.ca
authors.forename: Elan C
authors.initials: EC
authors.lastname: Paluck
authors.forename: James P
authors.initials: JP
authors.lastname: McCormack
authors.forename: Mary H H
authors.initials: MH
authors.lastname: Ensom
authors.forename: Marc
authors.initials: M
authors.lastname: Levine
authors.forename: Judith A
authors.initials: JA
authors.lastname: Soon
authors.forename: David W
authors.initials: DW
authors.lastname: Fielding
mesh_terms: D000328:Adult; D016642:Bupropion / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D016642:Bupropion