Diagnosis of polycystic ovaries by three-dimensional transvaginal ultrasound.
OBJECTIVE
To study diagnostic thresholds for polycystic ovary (PCO).


METHODS
Retrospective cohort study.


METHODS
Academic hospital.


METHODS
Normoandrogenic ovulatory women and patients with polycystic ovary syndrome (PCOS).


METHODS
Two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound.


METHODS
The mean follicle number per ovary (FNPO) of both ovaries and the maximum number follicles in a single sonographic plane (FSSP) of either ovary were determined using 3D transvaginal ultrasound. Ovarian volume was determined using 2D transvaginal ultrasound.


RESULTS
Twenty-nine normoandrogenic ovulatory women were compared with 10 patients with PCOS. Diagnostic thresholds for PCO with 100% specificity as determined by receiver operator characteristic (ROC) curves were > or =20 for mean FNPO, > or =10 for maximum FSSP, and > or =13 cm3 for ovarian volume. Both 2D and 3D transvaginal ultrasound were highly accurate in the diagnosis of PCO as determined by areas under the curve (AUC) that were >90% for all three measures.


CONCLUSIONS
Mean FNPO and maximum FSSP by 3D transvaginal ultrasound have comparable high accuracy for diagnosis of PCO. The diagnostic threshold with 100% specificity for mean FNPO is > or =20, which is greater than suggested by the Rotterdam Consensus Workshop in 2003. Use of the consensus standard, consequently, may result in overdiagnosis of PCO. A threshold of > or =20 mean FNPO using 3D transvaginal ultrasound may be appropriate to minimize false-positive diagnoses of PCO.
Allemand
Michael C
MC
Mayo Clinic College of Medicine, Rochester, Minnesota, USA. allemand.michael@mayo.edu
Tummon
Ian S
IS
Phy
Jennifer L
JL
Foong
Shu C
SC
Dumesic
Daniel A
DA
Session
Donna R
DR
D000328:Adult; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014463:Ultrasonography / Q000379:methods* / Q000592:standards; D014621:Vagina