title: SUSPECTS: enabling fast and effective prioritization of positional candidates.
abstract: SUSPECTS is a web-based server which combines annotation and sequence-based approaches to prioritize disease candidate genes in large regions of interest. It uses multiple lines of evidence to rank genes quickly and effectively while limiting the effect of annotation bias to significantly improve performance.
  
  
  BACKGROUND
  SUSPECTS is freely available at http://www.genetics.med.ed.ac.uk/suspects/
  
  
  BACKGROUND
  A quick-start guide in Macromedia Flash format is available at http://www.genetics.med.ed.ac.uk/suspects/help.shtml and Excel spreadsheets detailing the comparative performance of the software are included as Supplementary material.
authors.affiliation: Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK. euan.adie@ed.ac.uk
authors.forename: E A
authors.initials: EA
authors.lastname: Adie
authors.forename: R R
authors.initials: RR
authors.lastname: Adams
authors.forename: K L
authors.initials: KL
authors.lastname: Evans
authors.forename: D J
authors.initials: DJ
authors.lastname: Porteous
authors.forename: B S
authors.initials: BS
authors.lastname: Pickard
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D020407:Internet; D009862:Online Systems; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
chemical_list: D005819:Genetic Markers