title: Toxicity and gross pathology of ivermectin bath treatment in sea bream Sparus aurata, L.
abstract: The isopod parasite Ceratothoa oestroides becomes hard to eradicate in intensive fish rearing systems and in addition to causing weight loss in adult fish it causes mortalities in larval and juveniles stages of sea bass and sea bream. Faced with the fast emergence of this infection in Adriatic finfish facilities, an effective compound had to be tested for bath treatment. Ivermectin was chosen for this purpose on the basis of extensive practice in northern European countries which used ivermectin administered in food with good results in treatment of Lepeophtheirus sp. and Caligus sp. infections. For determination of toxicity of ivermectin, a short-term toxicity bioassay on 40-day-old sea bream, Sparus aurata, L., was conducted, following FAO and UNEP procedures for methodology in aquatic toxicity trials. Median survival time, slope functions, and 95% confidence limits for ivermectin showed moderate toxicity in sea bream, with first 100% mortalities during 96h at the concentration of 1.8 mg/L.
authors.affiliation: Institute of Oceanography and Fisheries, P.O. Box 500, 21000 Split, Croatia. mladineo@izor.hr
authors.forename: Ivona
authors.initials: I
authors.lastname: Mladineo
authors.forename: Jasna
authors.initials: J
authors.lastname: Marsic-Lucic
authors.forename: Mia
authors.initials: M
authors.lastname: Buzancic
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D005880:Gills / Q000187:drug effects / Q000473:pathology; D007559:Ivermectin / Q000633:toxicity*; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology; D008136:Longevity / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D021541:Sea Bream / Q000469:parasitology / Q000502:physiology*; D013997:Time Factors; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000977:Antiparasitic Agents; D014874:Water Pollutants, Chemical; D007559:Ivermectin