title: Different patterns of the fall of impedance as the result of heating during ostial pulmonary vein ablation: implications for power titration.
abstract: BACKGROUND
  A variety of strategies have been proposed to avoid the risks of pulmonary vein ablation for atrial fibrillation. The fall of impedance during radiofrequency catheter ablation can be used as a real time measure of tissue heating. The aim of this study was to analyze the impedance fall during ostial pulmonary vein ablation and to evaluate whether adjusting power to the fall of impedance may contribute to a reduction of the risk of complications.
  
  
  METHODS
  Analysis of biophysical parameters of ablation and determination of ostial diameters during follow-up were performed in 70 patients undergoing impedance-guided segmental ostial pulmonary vein ablation. Repeat radiographic angiography, local electrograms, and baseline impedance were the criteria to define the position of the 4-mm electrode tip at atrial sites or inside the proximal pulmonary veins.
  
  
  RESULTS
  Energy application inside the proximal pulmonary veins led to an increased impedance fall inside the first 5-10 mm of the pulmonary veins (1.1 +/- 0.5 Omega/W) as compared to ablation at atrial sites (0.7 +/- 0.3 Omega/W) (P < 0.01). The analysis of temperature and impedance fall during ostial ablation demonstrated an increased impedance fall with heating at sites inside the proximal pulmonary veins (1.5 +/- 0.6 Omega/ degrees C) as compared to atrial sites (1.2 +/- 0.5 Omega/ degrees C) (P < 0.001). The regression lines analyzing these correlations indicated that adjusting power to a maximum impedance fall of 20 Omega would limit heating at pulmonary venous sites to lower temperatures (average maximum temperature: 48 degrees C) than at atrial sites (average maximum temperature: 63 degrees C). The ablation strategy used for segmental ostial ablation in 70 patients, which involved power limitation to a maximum impedance fall of 20 Omega, allowed isolation of 89% of targeted pulmonary veins with a low rate of impedance rises (0.3% of applications). No pulmonary vein stenoses >30% were detected by follow-up computed tomography analysis.
  
  
  CONCLUSIONS
  An increased impedance fall as the result of heating during ostial ablation was found inside the proximal pulmonary veins as compared to atrial sites. Adjusting power to the fall of impedance during segmental ostial pulmonary vein ablation contributes to the prevention of overheating inside the pulmonary veins and may lower the risk of coagulum formation and pulmonary vein stenosis.
authors.affiliation: Medizinische Klinik I, Klinikum Grosshadern, Universität München, München, Germany. Christopher.Reithmann@med.uni-muenchen.de
authors.forename: Christopher
authors.initials: C
authors.lastname: Reithmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Remp
authors.forename: Ellen
authors.initials: E
authors.lastname: Hoffmann
authors.forename: Tomas
authors.initials: T
authors.lastname: Matis
authors.forename: Reza
authors.initials: R
authors.lastname: Wakili
authors.forename: Gerhard
authors.initials: G
authors.lastname: Steinbeck
mesh_terms: D001281:Atrial Fibrillation / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D017023:Coronary Angiography; D017097:Electric Impedance; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D011183:Postoperative Complications; D011667:Pulmonary Veins / Q000601:surgery*; D012086:Reoperation; D018709:Statistics, Nonparametric; D013696:Temperature; D014057:Tomography, X-Ray Computed