title: Cornual gestation: a systematic literature review and two case reports of a novel treatment regimen.
abstract: OBJECTIVE
  To introduce a novel tubal-sparing regimen for the treatment of nonruptured cornual pregnancies.
  
  
  METHODS
  Case report and systematic review of the literature.
  
  
  METHODS
  Tertiary Care University setting.
  
  
  METHODS
  Two patients referred for care in our subspecialty clinic.
  
  
  METHODS
  Laparoscopic surgery, dilation and evacuation, and postoperative methotrexate injection. Systematic review of the literature.
  
  
  RESULTS
  Both medical and surgical treatments for cornual gestation exist; however, each is not without its shortcomings. Medical treatment is associated with failure rates that may result in uterine rupture and catastrophic hemorrhage. Surgical treatment that involves hysterectomy causes a loss of future childbearing capability. Surgical treatment that involves resection of the involved cornual region is associated with decreased fertility rates and increased rates of uterine rupture in future pregnancies. Our treatment regimen is safe and effective and conserves future fertility.
  
  
  CONCLUSIONS
  A cornual gestation is one of the most hazardous types of ectopic gestation. The diagnosis and treatment of such a pregnancy is challenging and constitutes an urgent medical situation. We herein introduce a novel regimen for the treatment of nonruptured cornual pregnancies. The existing treatment regimens are also systematically reviewed.
authors.affiliation: Department of Obstetrics and Gynecology, University of Wisconsin, Madison, USA.
authors.forename: Reneita
authors.initials: R
authors.lastname: Ross
authors.forename: Steven R
authors.initials: SR
authors.lastname: Lindheim
authors.forename: David L
authors.initials: DL
authors.lastname: Olive
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Pritts
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D010535:Laparoscopy / Q000379:methods*; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000628:therapy*; D016896:Treatment Outcome; D014463:Ultrasonography; D014599:Uterus / Q000601:surgery*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate