'Double hit' from streptococcal pneumonia and hypersensitivity pneumonitis associated with anagrelide.
We report a case of unresolved streptococcal pneumonia in a patient taking anagrelide for essential thrombocythaemia. Resolution only occurred after discontinuing anagrelide and the institution of corticosteroid therapy, which resulted in dramatic improvement. There has been only one previous case report of anagrelide causing hypersensitivity pneumonia. We postulate this patient suffered a 'double hit' from streptococcal infection and anagrelide.
Spencer
E M
EM
Department of Respiratory Medicine, Arrowe Park Hospital, Wirral, UK. elspeth.spencer@btopenworld.com
Lawrence
D S
DS
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D011018:Pneumonia, Pneumococcal / Q000139:chemically induced* / Q000188:drug therapy; D011799:Quinazolines / Q000008:administration & dosage / Q000009:adverse effects*; D013920:Thrombocythemia, Essential / Q000150:complications*
D000305:Adrenal Cortex Hormones; D010975:Platelet Aggregation Inhibitors; D011799:Quinazolines; C021139:anagrelide