Marking emerging beta- and gammadelta-selected T cells.
How does signaling through the pre-TCR and gammadelta TCR generate distinct cell lineages? A new study shows that a cell-surface marker, CD27, identifies the first point of demarcation of these lineages and allows further probing into the critical regulatory factors that control beta and gammadelta selection.
Murre
Cornelis
C
Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, California 92093, USA.
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D019070:Cell Lineage; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis*
D015415:Biomarkers; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7