Analysis of the quantitative dermatoglyphic traits of the digito-palmar complex in patients with primary open angle glaucoma.
Patient with primary open angle glaucoma (PAOG), which is known to have a genetic predisposition, and their immediate relatives unaffected with PAOG, may have some changes in dermatoglyphic traits of the digito-palmar complex, since the trabecular meshwork develops at the same time and with the same hereditary base like dermatoglyphs, which have high genetic transmission. The objective of this study is to determine whether differences in quantitative dermatoglyphic traits of the digito-palmar complex exist between patients with glaucoma and the phenotipically healthy population and whether their family members have the same dermatoglyphic changes. The quantitative dermatoglyphic traits in patients suffering from glaucoma, first-degree members of their family and the phenotypically healthy population have been screened in this study. Descriptive statistics, univariate analysis of variance (ANOVA) and post hoc (Tukey HSD) method have been used. The results have shown that there is a link between the quantitative dermatoglyphic traits of the digito-palmar complex in patients affected by glaucoma and a first-degree healthy member of their family, as well as the difference between patients with glaucoma and their first-degree relatives, which may discriminate them from the phenotypically healthy population. The results of the study mostly affirm the existence of genetic predisposition for the development of primary open-angle glaucoma, thus emphasizing the relevance of hereditary factors in the etiopathogenesis of this disease.
Novak-Laus
Katia
K
University Department of Ophthalmology, University Hospital "Sestre milosrdnice", Zagreb, Croatia.
Milicić
Jasna
J
Tedeschi-Reiner
Eugenia
E
Iveković
Renata
R
Mijić
Vesna
V
Masnec-Paskvalin
Sanja
S
Zrinsćak
Ognjen
O
Mandić
Zdravko
Z
D000704:Analysis of Variance; D016022:Case-Control Studies; D017523:Croatia / Q000453:epidemiology; D003878:Dermatoglyphics; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005902:Glaucoma, Open-Angle / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male