Association between the brain-derived neurotrophic factor (BDNF) gene and schizophrenia in the Chinese population.
Brain-derived neurotrophic factor (BDNF) belongs to a family of the neurotrophin which plays important roles in the development of the brain. BDNF has been suggested as a factor that increases the risk of schizophrenia. In this study, we genotyped three single nucleotide polymorphisms (SNPs) in the BDNF gene using a set sample of Han Chinese subjects consisting of 560 schizophrenes and 576 controls. No significant differences were found for either the genotype or allele distribution of analyzed polymorphisms, nor was any gender-specific association found. Thus, our data suggest that the BDNF gene may not be an important factor in susceptibility to schizophrenia.
Chen
Qing-Ying
QY
Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China.
Chen
Qi
Q
Feng
Guo-Yin
GY
Wan
Chun-Ling
CL
Lindpaintner
Klaus
K
Wang
Li-Jun
LJ
Chen
Zheng-Xiong
ZX
Gao
Zhen-Song
ZS
Tang
Ji-Sheng
JS
Li
Xing-Wang
XW
He
Lin
L
D000328:Adult; D044466:Asian People; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor