Mitochondrial transfer between cells can rescue aerobic respiration.
Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria.
Spees
Jeffrey L
JL
Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Olson
Scott D
SD
Whitney
Mandolin J
MJ
Prockop
Darwin J
DJ
D000818:Animals; D001854:Bone Marrow Cells; D002460:Cell Line; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D018920:Coculture Techniques; D003470:Culture Media / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics; D005347:Fibroblasts / Q000378:metabolism; D015316:Genetic Therapy; D016678:Genome; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006801:Humans; D007511:Ischemia; D008928:Mitochondria / Q000378:metabolism*; D008957:Models, Genetic; D010101:Oxygen Consumption; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D014176:Protein Biosynthesis; D021381:Protein Transport; D013234:Stem Cells / Q000166:cytology; D013997:Time Factors
D003470:Culture Media; D004272:DNA, Mitochondrial; D049452:Green Fluorescent Proteins