A novel convenient synthesis of benzoquinazolines.
[reaction: see text] A novel synthetic pathway to benzoquinazolines from naphthylamines is reported. Benzoquinazoline nucleus was cyclized in good yield from N-protected naphthylamines using hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH. This method is efficient and convenient with respect to previously reported synthetic pathways.
Marzaro
Giovanni
G
Department of Pharmaceutical Sciences, University of Padova, Italy.
Chilin
Adriana
A
Pastorini
Giovanni
G
Guiotto
Adriano
A
D015081:2-Naphthylamine / Q000031:analogs & derivatives* / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D007202:Indicators and Reagents; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis*
D001555:Benzene Derivatives; D007202:Indicators and Reagents; D011799:Quinazolines; D015081:2-Naphthylamine