title: Toxic effects of brominated indoles and phenols on zebrafish embryos.
abstract: Organobromine compounds in the marine environment have been the focus of growing attention in past years. In contrast to anthropogenic brominated flame retardants, other brominated compounds are produced naturally, e.g., by common polychaete worms and algae. Brominated phenols and indoles assumed to be of biogenic origin have been detected in water and sediment extracts from the German Bight. These substances as well as some of their isomers have been tested with the zebrafish embryo test and were found to cause lethal as well as nonlethal malformations. The zebrafish test was able to detect a log K(OW)-related toxicity for bromophenols, suggesting nonpolar narcosis as a major mode of action. Different effect patterns could be observed for brominated indoles and bromophenols. The comparison of effective concentrations in the zebrafish embryo test with the concentrations determined in water samples suggests the possibility that brominated indoles may affect early life stages of marine fish species in the North Sea.
authors.affiliation: Federal Research Centre for Fisheries, Institute for Fishery Ecology, Palmaille 9, Hamburg 22767, Germany. ulrike.kammann@ifo.bfa-fisch.de
authors.forename: U
authors.initials: U
authors.lastname: Kammann
authors.forename: M
authors.initials: M
authors.lastname: Vobach
authors.forename: W
authors.initials: W
authors.lastname: Wosniok
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000187:drug effects*; D007211:Indoles / Q000633:toxicity*; D007928:Lethal Dose 50; D010636:Phenols / Q000633:toxicity*; D010858:Pigmentation / Q000187:drug effects; D021281:Quantitative Structure-Activity Relationship; D013131:Spine / Q000187:drug effects / Q000196:embryology; D015017:Yolk Sac / Q000187:drug effects; D015027:Zebrafish / Q000196:embryology*
chemical_list: D007211:Indoles; D010636:Phenols