Evaluation of colonoscopic allergen provocation as a diagnostic tool in dogs with proven food hypersensitivity reactions.
OBJECTIVE
To evaluate the colonoscopic allergen provocation (COLAP) test as a new tool for the diagnosis of IgE-mediated food allergy.


METHODS
Oral food challenges as well as COLAP testing were performed in a colony of nine research dogs with proven immediate-type food allergic reactions. In addition, COLAP was performed in five healthy dogs.


RESULTS
When compared with the oral challenge test, COLAP accurately determined 18 of 23 (73 per cent) positive oral challenge reactions (73 per cent) in dogs with food allergies and was negative in the healthy dogs.


CONCLUSIONS
The accuracy of this new test may be higher than that for gastric sensitivity testing. Therefore, COLAP holds promise as a new test to confirm the diagnosis of suspect IgE-mediated food allergy in dogs.
Allenspach
K
K
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Vaden
S L
SL
Harris
T S
TS
Gröne
A
A
Doherr
M G
MG
Griot-Wenk
M E
ME
Bischoff
S C
SC
Gaschen
F
F
D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D016022:Case-Control Studies; D003106:Colon / Q000276:immunology; D003113:Colonoscopy / Q000379:methods / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male
D000485:Allergens; D007073:Immunoglobulin E