Metformin-associated lactic acidosis precipitated by acute renal failure.
Metformin-associated lactic acidosis (MALA) is a rare but serious clinical entity. It is almost always seen in patients with a serious underlying medical disorder, most often a degree of renal impairment or other factors that are known to predispose to the lactic acidosis. We report a case of MALA in which acute renal failure resulting from hypovolemia secondary to acute gastroenteritis likely precipitated the condition. Early recognition of this condition and initiation of treatment are important. Bicarbonate hemodialysis is the treatment of choice.
Shenoy
Chetan
C
Department of Internal Medicine, Guthrie/Robert Packer Hospital, Sayre, PA 18840, USA. chetan_shenoy@yahoo.com
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000209:etiology / Q000628:therapy; D058186:Acute Kidney Injury / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008687:Metformin / Q000009:adverse effects*; D008875:Middle Aged
D007004:Hypoglycemic Agents; D008687:Metformin