Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1alpha as mast cell chemoattractants.
Follicular dendritic cell tumor (FDCT) is a rare tumor mainly located in laterocervical lymph nodes. We report one case of mediastinal FDCT associated with a history of bullous skin disease and clinically obvious immunosuppression. This tumor was characterized by heavy mast cell infiltration. Mast cells were in close relationship with tumor cells as demonstrated by ultrastructural examination and their presence are probably related with the strong expression of mast cell chemoattractants as fraktalkine and stromal cell-derived factor-1alpha by tumor cells. The long follow-up period of more than 17 years allowed to us assess the relatively indolent evolution of this tumor characterized by three slowly growing local recurrences without metastasis.
Guettier
Catherine
C
Department of Pathology, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Paul Brousse, 12 avenue Paul Vaillant-Couturier, UPRES 3541 Université PARIS XI, Villejuif cedex 94804, France. catherine.guettier@pbr.ap-hop-paris.fr
Validire
Pierre
P
Emilie
Dominique
D
Tricottet
Viviane
V
Sebagh
Mylène
M
Anjo
Aurora
A
Misset
Jean-Louis
JL
Reynes
Michel
M
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000032:analysis; D002630:Chemotactic Factors / Q000032:analysis; D020566:Dendritic Cells, Follicular / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D008224:Lymphoma, Follicular / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000737:chemistry; D008479:Mediastinal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D012367:RNA, Viral / Q000235:genetics; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D012367:RNA, Viral; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C515255:CXCL12 protein, human