Localized Kaposi's sarcoma in a patient with pemphigus vulgaris.
We report the case of a patient with a 13-year history of pemphigus vulgaris (PV) treated with immunosuppressive agents, prednisone and mycophenolate mofetil who had developed lesions of Kaposi's sarcoma (KS) on a sole plaque of PV that had been previously treated with intralesional injections of steroids. The lesions were surgically removed and polymerase chain reaction (PCR) demonstrated human herpesvirus-8 (HHV-8) DNA. There were neither recurrences nor later dissemination of KS following gradual decrease of the immunosuppressive therapy. We suggest that the treatment with intralesional steroids may have influenced the local reactivation of a latent infection of the virus, determining the appearance of this localized KS.
Avalos-Peralta
P
P
Department of Dermatology, Virgen Macarena University Hospital, Seville, Spain. avalosperalta@yahoo.es
Herrera
A
A
Ríos-Martín
J J
JJ
Pérez-Bernal
A M
AM
Moreno-Ramírez
D
D
Camacho
F
F
D000368:Aged; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D010392:Pemphigus / Q000188:drug therapy*; D016133:Polymerase Chain Reaction; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000139:chemically induced* / Q000821:virology
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D011241:Prednisone