[The role of interleukin-5 in manifestation of bronchial hyperreactivity (an experimental study)].
Mechanography was used to study contractile reaction of airway smooth muscles in experimental bronchial asthma in intact guinea-pigs and those incubated with IL-5. Development of experimental bronchial asthma (BA) in the animals leads to enhancement of contractile reactions of bronchial smooth muscles in response to histamine action. The exposure to IL-5 of the preparations of bronchial smooth muscles increases histamine-mediated bronchial contractility. This may explain the phenomenon of IL-5-mediated bronchial hyperreactivity in the absence of eosinophilic damage to the tissues. Expression of mRNA of IL-5 receptor alpha-chain suggests that development of IL-5-mediated hypersensitivity of bronchial smooth muscles occurs due to the presence of a relevant IL-5 receptor on their surface.
Sazonov
A E
AE
Ivanchuk
I I
II
Kapilevich
L V
LV
D'iakova
E Iu
EIu
Popova
I S
IS
Nosarev
A V
AV
Zaĭtseva
T N
TN
Tyryshkin
A M
AM
Ogorodova
L M
LM
D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000473:pathology*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000473:pathology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D015848:Interleukin-5 / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D018123:Receptors, Interleukin / Q000187:drug effects / Q000235:genetics; D053649:Receptors, Interleukin-5
D015848:Interleukin-5; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5; D006632:Histamine