title: Nonsuture dural repair using polyglycolic acid mesh and fibrin glue: clinical application to spinal surgery.
abstract: BACKGROUND
  In spinal surgery, repair of the dura is difficult when it is torn or fragile or is ossified as in cases with ossification of posterior longitudinal ligament. We report our experience with a nonsuture dural repair technique in patients undergoing spinal surgery; it uses a dura substitute composed of polyglycolic acid (PGA) mesh and fibrin glue. Here, we report the efficacy and safety of nonsuture duroplasty using PGA mesh and fibrin glue (PGA-fibrin sheet).
  
  
  METHODS
  The artificial dura mater is composed of a PGA-fibrin sheet. The dural defect is covered with a patch sprayed with fibrin glue without suturing to the dura mater. We first evaluated this technique in an experimental study by performing water leakage tests. Between May 2001 and January 2005, we used it in 160 spinal surgeries that required intraoperative dura repair.
  
  
  RESULTS
  Our preliminary tests showed that the threshold for water pressure without leakage was 161 +/- 42 and 96.5 +/- 32 mm Hg when the unsprayed margin around the perimeter of the patch was 5 and 2 mm, respectively. Of the 160 operated patients, 10 (6.3%) experienced subcutaneous cerebrospinal fluid (CSF) leakage. Of these, 6 required a second operation; in the other 4, the CSF collection diminished spontaneously. There were no other complications such as allergic reaction, adhesion, or infection.
  
  
  CONCLUSIONS
  In combination with CSF diversion, the PGA-fibrin sheet is a viable alternative method for dural repair in spinal surgery.
authors.affiliation: Department of Neurosurgery, University of Hokkaido, Graduate School of Medicine, Sapporo 060-8638, Japan. kazuhida@med.hokudai.ac.jp
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Hida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Seki
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yano
authors.forename: Minoru
authors.initials: M
authors.lastname: Akino
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Terasaka
authors.forename: Takanori
authors.initials: T
authors.lastname: Uchida
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D001139:Arnold-Chiari Malformation / Q000601:surgery; D002555:Cerebrospinal Fluid / Q000378:metabolism; D004388:Dura Mater / Q000601:surgery*; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008422:Materials Testing; D017887:Ossification of Posterior Longitudinal Ligament / Q000601:surgery; D011100:Polyglycolic Acid; D011312:Pressure; D013131:Spine / Q000601:surgery*; D013526:Surgical Mesh; D013595:Syringomyelia / Q000601:surgery; D014014:Tissue Adhesives; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D011100:Polyglycolic Acid