Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical "two-hit" model.
Golub
L M
LM
Department of Oral Biology & Pathology, School of Dental Medicine, SUNY at Stony Brook, Stony Brook, NY, USA. lgolub@epo.hsc.sunysb.edu
Payne
J B
JB
Reinhardt
R A
RA
Nieman
G
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003773:Dental Plaque / Q000150:complications; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D015663:Osteoporosis, Postmenopausal / Q000150:complications; D010518:Periodontitis / Q000188:drug therapy / Q000209:etiology*; D011480:Protease Inhibitors / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D011480:Protease Inhibitors