[Interregulation of VEGF/R endostatin and MMP in the angiogenesis of hematologic malignancies--review].
Some kinds of angiogenic correlation factors, e.g. VEGF/R, MMP, endo statin, are relative to the process of hematologic malignancies. The mechanisms of adjusting themselves and controlling mutually have been hot points of the academic research in last few years. Although the rapid progress has been made in studies of this field, it is still hard to come into a systematic theory now. This article introduces the last progress in the field of positive and negative regulatory factors of VEGF/R system in the angiogenesis of hematologic malignancies, the regulation of MMP and its relation with VEGF/R, the regulation of ES and its relation with VEGF/R and MMP.
Zhang
Jian-Dong
JD
Department of Internal Medicine, Medical College of Yangzhou University, Yangzhou 225001, China.
Zhang
Yu
Y
D043169:Endostatins / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism*
D043169:Endostatins; D040262:Receptors, Vascular Endothelial Growth Factor; D020782:Matrix Metalloproteinases