Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer.
OBJECTIVE
To examine the outcome of in vitro fertilization according to the body mass index of infertile patients.


METHODS
Between September 2003 and May 2005, 573 patients underwent 789 in vitro fertilization cycles or ICSI because of male factor, tubal factor, and unexplained infertility were retrospectively included from our IVF database. The patients were classified in four groups: BMI<20 kg/m2 (264 cycles), 20< or = BMI<25 (394 cycles), 25< or = BMI < 30 (83 cycles), and BMI> or = 30 (48 cycles). All patients had a long protocol for IVF with a combination of the GnRH agonist and recombinant FSH.


RESULTS
All parameters of ovarian response were comparable except the total required r-FSH dose. This dose was statistically higher in the group of BMI> or = 30 compared to the other groups (p = 0.0003). All parameters of IVF outcome were comparable, including the cancellation rate, the implantation rate, and pregnancy rates.


CONCLUSIONS
Obese patients require a higher r-FSH dose to achieve follicular maturation than normal weight patients. Obesity does not affect negatively results of in vitro fertilization.
Dechaud
Herve
H
Service de Gynécologie-Obstétrique et Médecine de la Reproduction, CHU Arnaud De Villeneuve, Faculté de Médecine, Université Montpellier I, 371 avenue du Doyen Gaston GIRAUD, 34295 Montpellier Cedex 5, France. h-dechaud@chu-montpellier.fr
Anahory
Tal
T
Reyftmann
Lionel
L
Loup
Vanessa
V
Hamamah
Samir
S
Hedon
Bernard
B
D000328:Adult; D015992:Body Mass Index; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005602:France / Q000453:epidemiology; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D009765:Obesity; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology; D010062:Ovulation Induction / Q000009:adverse effects; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic