Normal hydrocarbons tumble rapidly in a deep, water-soluble cavitand.
A deep, water-soluble cavitand extracts n-alkanes and other water-insoluble species into its cavity via hydrophobic forces: alkanes bind in a helical manner, and tumble rapidly on the NMR timescale inside the binding pocket.
Hooley
Richard J
RJ
Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Biros
Shannon M
SM
Rebek
Julius
J
D000473:Alkanes / Q000737:chemistry; D001665:Binding Sites; D004988:Ethers, Cyclic / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012118:Resorcinols / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
D000473:Alkanes; D004988:Ethers, Cyclic; D006838:Hydrocarbons; D012118:Resorcinols; C442939:cavitand; D014867:Water