HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR THEDETERMINATION OF PARACETAMOL, PSEUDOEPHEDRINE HCl ANDTRIPROLIDINE HCI IN PHARMACEUTICAL PREPARATIONS.
The knowledge of UV absorption characteristics of paracetatmol, pseudoephedrine HCl and triprolidine HCl has been used to determine these compounds by HPLC method in pharmaceutical preparations. The method involves reverse phase chromatography with isocratic mode of elusion. Rather selecting a compromised wavelength for all the three components, "wavelength switching" programme has been executed to give reasonable UV responses because of the widely different UV characteristics of these components. This method performs well in term of the precision and accuracy as indicated by linear regression analysis. The RSD of the method is 1.12 to 2.87% and the recovery is 103.10-95.56%.
Akhtar
M J
MJ
Research and Development Laboratories, Welcome Pakistan Ltd., D/43, S.I.T.E., Karachi, Pakistan.
Khan
S U
SU
Khan
M A
MA