title: Acquired amegakaryocytic thrombocytopenic purpura.
abstract: Acquired amegakaryocytic thrombocytopenia is an unusual hematologic disorder characterized by thrombocytopenia in association with markedly diminished bone marrow megakaryocytes. We report a case that responded to treatment with cyclosporine but not to IL-11. The bone marrow biopsy, repeated after resolution of thrombocytopenia, showed normal number of megakaryocytes.
authors.affiliation: Division of Hematology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Agarwal
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Spahr
authors.forename: Theresa L
authors.initials: TL
authors.lastname: Werner
authors.forename: David L
authors.initials: DL
authors.lastname: Newton
authors.forename: George M
authors.initials: GM
authors.lastname: Rodgers
mesh_terms: D001854:Bone Marrow Cells; D002452:Cell Count; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017370:Interleukin-11 / Q000494:pharmacology / Q000627:therapeutic use*; D008533:Megakaryocytes / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D017370:Interleukin-11; D016572:Cyclosporine