title: Role of phase variation of type 1 fimbriae in a uropathogenic Escherichia coli cystitis isolate during urinary tract infection.
abstract: Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage.
authors.affiliation: Department of Microbiology and Immunology, Baltimore, MD 21201, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Snyder
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Lloyd
authors.forename: C Virginia
authors.initials: CV
authors.lastname: Lockatell
authors.forename: David E
authors.initials: DE
authors.lastname: Johnson
authors.forename: Harry L T
authors.initials: HL
authors.lastname: Mobley
mesh_terms: D000818:Animals; D015169:Colony Count, Microbial; D003556:Cystitis / Q000382:microbiology; D004926:Escherichia coli / Q000145:classification* / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007668:Kidney / Q000382:microbiology; D051379:Mice; D008808:Mice, Inbred CBA; D009154:Mutation; D001743:Urinary Bladder / Q000382:microbiology; D014552:Urinary Tract Infections / Q000382:microbiology*; D014556:Urine / Q000382:microbiology; D014774:Virulence
chemical_list: D029968:Escherichia coli Proteins