title: Prognostic factors for surgery of neocortical temporal lobe epilepsy.
abstract: OBJECTIVE
  In the current classification of epilepsies two forms of temporal lobe epilepsy (TLE) were included: mesial and lateral (neocortical) TLE. We aimed at identifying prognostic factors for the surgical outcome of lesional neocortical TLE.
  
  
  METHODS
  We included consecutive patients who had undergone presurgical evaluation including ictal video-EEG and high-resolution MRI, who had TLE due to neocortical lateral epileptogenic lesions, who had a lesionectomy and who had >2-year follow-up.
  
  
  RESULTS
  There were 29 patients who met the inclusion criteria. Twenty of them became postoperatively seizure-free. Patients' mean age was 34.8+/-9 years (range 18-52). The age at epilepsy onset was 20.1+/-8 years. We found that left-sided surgery (p=0.048) and focal cortical dysplasia (FCD) on MRI (p=0.005) were associated with non-seizure-free outcome, while lateralized/localized EEG seizure pattern (p=0.032), tumors on the MRI (p=0.013), and a favorable seizure situation at the 6-month postoperative evaluation were associated with 2-year postoperative seizure-freedom (p<0.001). Multivariate analysis indicated that the side of surgery was not an independent predictor.
  
  
  CONCLUSIONS
  More than two-thirds of the patients with neocortical TLE became seizure-free postoperatively. Lateralized/localized EEG seizure pattern and tumors on the MRI were associated with postoperative seizure-freedom, while FCD were associated with a poor outcome. The 6-month postoperative outcome is a reliable predictor for the long-term outcome.
authors.affiliation: Epilepsy Centre Bethel, Bielefeld, Germany; Department of Neurology, University of Pécs, Pécs, Hungary. jozsef.janszky@aok.pte.hu
authors.forename: J
authors.initials: J
authors.lastname: Janszky
authors.forename: H W
authors.initials: HW
authors.lastname: Pannek
authors.forename: A
authors.initials: A
authors.lastname: Fogarasi
authors.forename: B
authors.initials: B
authors.lastname: Bone
authors.forename: R
authors.initials: R
authors.lastname: Schulz
authors.forename: F
authors.initials: F
authors.lastname: Behne
authors.forename: A
authors.initials: A
authors.lastname: Ebner
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000473:pathology*; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome