title: Recurrent painful unilateral gynaecomastia-interactions between hyperthyroidism and hypogonadism.
abstract: We report an unusual case of recurrent, painful, unilateral gynaecomastia (GM) in an elderly male with relapsing Graves' hyperthyroidism and co-existing primary hypogonadism. This patient presented to the Breast Clinic with a 4-month history of painful, right GM. Malignancy was excluded but T3 was noted to be raised at 7.3 pmol l(-1) (normal 3.5-5.5) with a suppressed thyroid-stimulating hormone. Testosterone, luteinizing hormone and follicle-stimulating hormone were consistent with primary hypogonadism. He was later referred to physicians with night sweats and painful right GM. FT3 was 7.4 and carbimazole was commenced. Within 4 months, the night sweats and right GM had resolved but he became hypothyroid. When carbimazole was stopped, right GM recurred together with hyperthyroidism. The male breast, which is sensitive to subtle changes in T/E2 ratio, is more likely to be stimulated in an elderly male with hyperthyroidism and pre-existing hypogonadism, and hence recurrence of GM with relapsing hyperthyroidism. Recognition of this association is clinically relevant to avoid unnecessary investigations and undue patient anxiety, and to facilitate appropriate early diagnosis and treatment.
authors.affiliation: Department of Endocrinology, Cumberland Infirmary, Carlisle, UK. m.k.jayapaul@ncl.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Jayapaul
authors.forename: M R
authors.initials: MR
authors.lastname: Williams
authors.forename: D P
authors.initials: DP
authors.lastname: Davies
authors.forename: D M
authors.initials: DM
authors.lastname: Large
mesh_terms: D000369:Aged, 80 and over; D000728:Androgens / Q000097:blood; D013956:Antithyroid Agents / Q000627:therapeutic use; D002231:Carbimazole / Q000627:therapeutic use; D004967:Estrogens / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006177:Gynecomastia / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007006:Hypogonadism / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010146:Pain / Q000503:physiopathology; D012008:Recurrence; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014284:Triiodothyronine / Q000097:blood / Q000627:therapeutic use
chemical_list: D000728:Androgens; D013956:Antithyroid Agents; D004967:Estrogens; D014284:Triiodothyronine; D013739:Testosterone; D002231:Carbimazole; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin