title: Seroepidemiology of strongyloidiasis in the Peruvian Amazon.
abstract: A stool and serosurvey for Strongyloides stercoralis was conducted in a community in the Peruvian Amazon region. Strongyloidiasis stercoralis was identified in the stool of 69 (8.7%) of 792 participants. Six hundred nine sera were tested using by an enzyme-linked immunosorbent assay (ELISA), which had a sensitivity of 92% and a specificity of 94%; 442 (72%) were positive. In multivariable logistic regression models, having S. stercoralis in stool was associated with hookworm in the same specimen (odds ratio [OR] = 4.44, 95% confidence interval [CI] = 2.02-9.79), occasionally or never wearing shoes (OR = 1.89, 95% CI = 1.10-3.27), and increasing age (OR = 1.012 for each one-year increase, 95% CI = 1.00-1.03). Similarly, occasionally or never wearing shoes (OR = 1.54, 95% CI = 1.01-2.37) and increasing age (OR = 1.04 for each one-year increase, 95% CI = 1.02-1.06) were associated with an increased risk of a positive S. stercoralis ELISA result. The ELISA had a negative predictive value of 98% and is an excellent screening test for strongyloidiasis.
authors.affiliation: Asociacion Benefica PRISMA, Lima, Peru.
authors.forename: Pablo P
authors.initials: PP
authors.lastname: Yori
authors.forename: Margaret
authors.initials: M
authors.lastname: Kosek
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Julianna
authors.initials: J
authors.lastname: Cordova
authors.forename: Caryn
authors.initials: C
authors.lastname: Bern
authors.forename: Cesar Banda
authors.initials: CB
authors.lastname: Chavez
authors.forename: Maribel Paredes
authors.initials: MP
authors.lastname: Olortegui
authors.forename: Carmen
authors.initials: C
authors.lastname: Montalvan
authors.forename: Graciela Meza
authors.initials: GM
authors.lastname: Sanchez
authors.forename: Bevelle
authors.initials: B
authors.lastname: Worthen
authors.forename: James
authors.initials: J
authors.lastname: Worthen
authors.forename: Fay
authors.initials: F
authors.lastname: Leung
authors.forename: Carlos Vidal
authors.initials: CV
authors.lastname: Oré
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D005260:Female; D005368:Filariasis / Q000175:diagnosis; D006725:Hookworm Infections / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010568:Peru / Q000453:epidemiology; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012775:Shoes; D017171:Strongyloides stercoralis / Q000276:immunology / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000097:blood / Q000453:epidemiology* / Q000276:immunology