Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms.
Resveratrol has been demonstrated to produce a variety of biological actions. Accumulating line of evidence supported the view that resveratrol may exert protective effect on the cardiovascular system. The aim of the study was to assess the antiarrhythmic profile as well as electrophysiological properties of resveratrol. We observe the antiarrhythmic effect of resveratrol on aconitine induced rat arrhythmia, ouabain induced guinea pig arrhythmia, and coronary ligation induced rat arrhythmia animal models. Resveratrol significantly and dose-dependently increased the doses of aconitine and ouabain required to induce the arrhythmia indexes. In coronary ligation induced rat arrhythmia model, resveratrol shortened duration of arrhythmia, decreased incidence of ventricular tachycardia and mortality. Electrophysiological experiment revealed that resveratrol could shorten APD through inhibition of ICa and selective enhancement of IKs without an effect on IKr.
Zhang
Yan
Y
Department of Pharmacology, Harbin Medical University, and Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, PR China.
Liu
Yanyan
Y
Wang
Tao
T
Li
Baoxin
B
Li
Houwei
H
Wang
Zhiguo
Z
Yang
Baofeng
B
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D006168:Guinea Pigs; D015640:Ion Channel Gating / Q000187:drug effects*; D032342:Muscle Cells / Q000187:drug effects* / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D015996:Survival Rate; D016896:Treatment Outcome; D027843:Vitis / Q000737:chemistry
D000889:Anti-Arrhythmia Agents; D010936:Plant Extracts; D013267:Stilbenes; D000077185:Resveratrol