title: [The relationship between the five beta-fibrinogen gene polymorphisms and cerebral infarction].
abstract: OBJECTIVE
  To investigate the relationship among beta-fibrinogen (Fg) concentration, related gene polymorphisms (including -148C/T, -249C/T, -455G/A, 448G/A, 1689T/G) and cerebral infarction.
  
  
  METHODS
  Fg level and its five gene polymorphisms were analyzed with by polymerase chain reaction-restriction fragment length polymorphism in 132 patients with cerebral infarction, 79 patients with other neurological diseases and 92 healthy elders.
  
  
  RESULTS
  The plasma Fg level in cerebral infarction patients was significantly higher than that in the patients with other neurological diseases or healthy elders (P < 0.05). In the three groups, the plasma Fg levels in individuals with T-148 and A-455 alleles were higher than those in individuals without T-148 and A-455 alleles (P < 0.05). However, there were no statistically significant differences in the genotype and allele frequencies in the five mutation gene polymorphisms among the three groups (P > 0.05).
  
  
  CONCLUSIONS
  Cerebral infarction is a multifactorial disease and an increased Fg level is a risk factor for cerebral infarction. T-148 and A-455 allele can lead to elevated Fg concentration.
authors.affiliation: Department of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Fu
authors.forename: Xin
authors.initials: X
authors.lastname: Wei
authors.forename: Pei-hua
authors.initials: PH
authors.lastname: Ni
authors.forename: Ya-yun
authors.initials: YY
authors.lastname: Ying
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Song
authors.forename: Sheng-di
authors.initials: SD
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005340:Fibrinogen