[Role of a comprehensive genetic prognosis in the treatment and prevention of respiratory tuberculosis in adolescents].
The paper presents the results of a follow-up and treatment of 75 adolescents with pulmonary tuberculosis. It assesses the predictive value of different alleles of the gene HLA-DRB1 and the genotype of Mycobacterium tuberculosis for the clinical course of pulmonary tuberculosis in the adolescents. An algorithm of examination of an adolescent with tuberculosis has been developed, by using a complex of genetic parameters. A differential approach to tuberculosis prevention and treatment regimens is presented by taking into account of genetic characteristics of gross and microorganisms.
Pavlova
M V
MV
Skvortsova
L A
LA
Kondakova
M N
MN
Kovaleva
R G
RG
D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005787:Gene Frequency; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D012140:Respiratory Tract Diseases / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy*; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000517:prevention & control*
D000995:Antitubercular Agents; D006684:HLA-DR Antigens