Pravastatin-induced lichenoid drug eruption.
SUMMARY A 64-year-old woman presented with diffuse and numerous pigmented macules on her face and upper back. Histopathological examination of a skin punch biopsy of the rash showed a lichenoid dermatitis. The most likely offending drug was pravastatin. Cessation of pravastatin resulted in gradual fading of the pigmentation. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors have previously been reported to cause lichenoid drug eruptions.
Pua
Vernon Sc
VS
Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Scolyer
Richard A
RA
Barnetson
Ross Stc
RS
D001707:Biopsy, Needle; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D017035:Pravastatin / Q000009:adverse effects* / Q000627:therapeutic use; D012720:Severity of Illness Index
D017035:Pravastatin