title: Combined spinal epidural causes higher level of block than equivalent single-shot spinal anesthesia in elective cesarean patients.
abstract: Combined spinal epidural (CSE) is an established technique for lower segment cesarean delivery. In this study we tested the hypothesis that the spinal block from a CSE technique results in a more extensive spread of local anesthetic in the subarachnoid space than the single-shot spinal (SSS) technique. We recruited 30 ASA physical status I parturients admitted for elective lower segment cesarean delivery into our randomized, controlled, double-blind study. All patients intrathecally received 2 mL of 0.5% hyperbaric bupivacaine. The patients were randomized into one of the two groups using sealed opaque envelopes. Group S (n = 15) received a SSS technique. Group CS (n = 15) received a CSE technique using loss of resistance to 2 mL of air, but the epidural catheter was not inserted after the intrathecal drug administration. The maximal sensory block achieved in group CS was statistically higher than that in Group S (median C6 interquartile range, C5 to C8 versus median T3, T2 to T4, P < 0.001). Time taken to reach maximal sensory block was significantly longer in group CS. There were no differences in the time taken for the block to recede to T10, hemodynamic profile, or side effects. In conclusion, the CSE technique without placing an epidural catheter or administering epidural medication resulted in a significantly higher level of sensory block when compared with the SSS technique when the same dose of local anesthetic was given intrathecally.
authors.affiliation: Department of Women's Anesthesia, KK Women's and Children's Hospital, Singapore.
authors.forename: Farida
authors.initials: F
authors.lastname: Ithnin
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Lim
authors.forename: Alex T
authors.initials: AT
authors.lastname: Sia
authors.forename: Cecilia E
authors.initials: CE
authors.lastname: Ocampo
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000008:administration & dosage; D002045:Bupivacaine / Q000008:administration & dosage; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D011247:Pregnancy
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine