title: Macrophages isolated from chickens genetically resistant or susceptible to systemic salmonellosis show magnitudinal and temporal differential expression of cytokines and chemokines following Salmonella enterica challenge.
abstract: Macrophages from inbred chickens that are resistant to salmonellosis show greater and more rapid expression of proinflammatory chemokines and cytokines, including the key Th1-inducing cytokine interleukin-18, upon Salmonella challenge than those from susceptible birds. This suggests the possibility that salmonellosis resistant-line macrophages signal more effectively and rapidly and are more able to induce protective Th1 adaptive responses.
authors.affiliation: Department of Veterinary Pathology, University of Liverpool, Leahurst, Neston CH64 0SH, United Kingdom. Paul.Wigley@liverpool.ac.uk
authors.forename: Paul
authors.initials: P
authors.lastname: Wigley
authors.forename: Scott
authors.initials: S
authors.lastname: Hulme
authors.forename: Lisa
authors.initials: L
authors.lastname: Rothwell
authors.forename: Nat
authors.initials: N
authors.lastname: Bumstead
authors.forename: Pete
authors.initials: P
authors.lastname: Kaiser
authors.forename: Paul
authors.initials: P
authors.lastname: Barrow
mesh_terms: D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D002645:Chickens / Q000276:immunology / Q000382:microbiology*; D015169:Colony Count, Microbial; D016207:Cytokines / Q000378:metabolism*; D007113:Immunity, Innate; D008264:Macrophages / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D011201:Poultry Diseases / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D019779:Salmonella enterica / Q000276:immunology / Q000472:pathogenicity*; D012486:Salmonella typhimurium / Q000276:immunology / Q000472:pathogenicity*; D013047:Specific Pathogen-Free Organisms
chemical_list: D018925:Chemokines; D016207:Cytokines