title: A novel series of urea-based peptidomimetic calpain inhibitors.
abstract: A series of peptide aldehyde derivatives in which the P(2) chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of mu-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for mu-calpain over cathepsin B.
authors.affiliation: Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: M Lee
authors.initials: ML
authors.lastname: Sanders
authors.forename: Isaac O
authors.initials: IO
authors.lastname: Donkor
mesh_terms: D002154:Calpain / Q000037:antagonists & inhibitors*; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D018716:Molecular Mimicry; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D015853:Cysteine Proteinase Inhibitors; D014508:Urea; D002154:Calpain