Serum antioxidant enzymes and malondialdehyde levels in patients with premature ejaculation before and after pharmacotherapy.
BACKGROUND
In our previous study, significantly higher antioxidant enzymes and malondialdehyde (MDA) levels in patients with premature ejaculation (PE) compared to healthy controls were found. In the present study, we planned to evaluate antioxidant enzymes and MDA levels of patients with PE before and after citalopram treatment.


METHODS
The study comprised 30 patients with PE according to Diagnostic and Statistical Manual of Mental Disorders Fourth Version (DSM-IV) and 30 healthy controls. The patients were randomly assigned to two groups. Fifteen of them (group I) received 8 weeks of citalopram treatment but the remaining (group II) did not. The subjects were asked to determine the average intravaginal ejaculation latency time (IVELT). The fasting antioxidant enzymes and MDA levels were measured at baseline and after 8 weeks.


RESULTS
No statistically significant difference in the mean IVELT between groups at baseline was found. IVELT considerably elevated after 8 weeks of citalopram treatment in group I with a mean of 209 +/- 72.1 seconds but not in group II. Antioxidant enzymes and MDA levels did not differ between groups at baseline. At the evaluation of week 8, SOD, GSH-Px, and MDA levels significantly reduced during treatment in group I patients.


CONCLUSIONS
In conclusion, the results suggest that the ability for antioxidant enzymes and MDA to normalize through symptom alleviation reveals that they might be trait marker of PE. Further placebo-controlled studies are needed.
Atmaca
Murad
M
Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey.
Karadag
Figen
F
Tezcan
Ertan
E
D000328:Adult; D015283:Citalopram / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D010088:Oxidoreductases / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012735:Sexual Dysfunction, Physiological / Q000097:blood* / Q000188:drug therapy*
D015283:Citalopram; D008315:Malondialdehyde; D010088:Oxidoreductases; D017367:Selective Serotonin Reuptake Inhibitors