[Cyclopheron pretreatment in opisthorchiasis management in patients with viral hepatitis C].
OBJECTIVE
To assess efficacy of cyclopheron (Polysan production) as opisthorchiasis pretreatment in patients with chronic viral hepatitis C (CHC).


METHODS
Fifteen CHC patients received cyclopheron by 6 month scheme before dehelminthization. The effect was evaluated by dynamics of clinical symptoms, results of functional hepatic tests, levels of autoantibodies to antigens of native and denaturated DNA, CIC and lactoferrin. Fourteen control patients did not receive pretreatment with cyclopheron.


RESULTS
The study group patients exhibited a relief of asthenovegetative and pain syndromes, aminotranspherases lowered to normal in 11 patients, minimal activity of cytolytic syndrome--in 4 patients. Lactoferrin normalized in all the patients, coefficient of autoantibodies to antigens of native and denaturated DNA fell two-fold. No significant improvement in the clinical and laboratory picture was seen in the controls.


CONCLUSIONS
Cyclopheron in patients with CHC combination with chronic opisthorchiasis is recommended as pretreatment before dehelminthization.
Paltseva
A I
AI
Trunova
A N
AN
Iakhina
S V
SV
D000166:Acridines / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000097:blood; D018509:DNA, Helminth / Q000097:blood; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000469:parasitology*; D006801:Humans; D007369:Interferon Inducers / Q000009:adverse effects / Q000627:therapeutic use*; D007781:Lactoferrin / Q000097:blood; D008297:Male; D009889:Opisthorchiasis / Q000150:complications / Q000188:drug therapy*; D009891:Opisthorchis; D016896:Treatment Outcome
D000166:Acridines; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D018509:DNA, Helminth; D007369:Interferon Inducers; D007781:Lactoferrin; C026430:10-carboxymethyl-9-acridanone