Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins.
The endothelins are a family of hormones that have a biphasic action on pituitary lactotrophs. The initial effect is stimulatory, followed later by inhibition that persists long after the agonist has been removed. Recent research has uncovered several G protein pathways that mediate these effects.
Bertram
Richard
R
Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA. bertram@math.fsu.edu
Tabak
Joel
J
Toporikova
Natalia
N
Freeman
Marc E
ME
D000262:Adenylyl Cyclases / Q000502:physiology; D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D019332:Endothelin-1 / Q000494:pharmacology / Q000502:physiology; D016232:Endothelins / Q000235:genetics / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology; D044385:GTP-Binding Protein alpha Subunits / Q000502:physiology; D019204:GTP-Binding Proteins / Q000145:classification / Q000502:physiology*; D006801:Humans; D007295:Inositol Phosphates / Q000502:physiology; D008954:Models, Biological; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D024681:Potassium Channels, Calcium-Activated / Q000502:physiology; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D044022:Receptor, Endothelin A / Q000187:drug effects / Q000502:physiology; D017466:Receptors, Endothelin / Q000187:drug effects / Q000502:physiology*; D050600:SNARE Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000502:physiology
D019332:Endothelin-1; D016232:Endothelins; D044385:GTP-Binding Protein alpha Subunits; C490963:Gnaz protein, rat; D007295:Inositol Phosphates; D024681:Potassium Channels, Calcium-Activated; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin; D050600:SNARE Proteins; C118500:inositol 3,4,5-trisphosphate; D011388:Prolactin; D000242:Cyclic AMP; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases; D004298:Dopamine