title: Synthesis and antibacterial activity of 1beta-methyl-2-[5-(1,2-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem derivatives.
abstract: The synthesis of a new series of 1beta-methylcarbapenems having a 5-(1,2-disubstituted ethyl) pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the pyrrolidine ring was investigated. A particular compound IIIf having a 1-methoxyimino-2-carbamoylethyl substituted moiety showed the most potent antibacterial activity.
authors.affiliation: Department of Chemistry, Hanyang University, Seoul, Korea.
authors.forename: Soo-Hyun
authors.initials: SH
authors.lastname: Ahn
authors.forename: Heechol
authors.initials: H
authors.lastname: Jeon
authors.forename: Joung-Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Daejin
authors.initials: D
authors.lastname: Baek
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Seo
authors.forename: Jung-Hyuck
authors.initials: JH
authors.lastname: Cho
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015780:Carbapenems; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems