The effects of mefenamic acid on the osmotic fragility of lacertilian erythrocytes.
Osmotic fragility of red cells is increased by the use of mefenamic acid. The use of this analgesic induces hemolytic anemia. Study of osmotic fragility of RBCs of control and test was observed following administration of 7.1 mg, 10.5 mg and 14 mg/day mefenamic acid to each lizard. Increased osmotic fragility was observed with increase in the amount of dose on day 6 and day 12.
Ahmad
Mahmood
M
Department of Physiology, University of Karachi, Karachi-75270, Pakistan.
Hasan
Ruqaiya
R
Qureshi
Anila
A
Ahmad
Mansoor
M
Ahmed
Zulfiqar
Z
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D007038:Hypotonic Solutions / Q000008:administration & dosage; D008116:Lizards / Q000097:blood*; D008528:Mefenamic Acid / Q000008:administration & dosage / Q000633:toxicity*; D009996:Osmotic Fragility / Q000187:drug effects; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007038:Hypotonic Solutions; D008528:Mefenamic Acid; D012965:Sodium Chloride