Total synthesis of (+)-cylindramide A.
A total synthesis of cylindramide A has been completed in 19 steps. The key step of the synthesis is a tandem ring-opening-ring-closing-cross metathesis that converts a readily available norbornene into an advanced intermediate.
Hart
Amy C
AC
Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309-0215, USA.
Phillips
Andrew J
AJ
D000818:Animals; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009636:Norbornanes / Q000737:chemistry; D011161:Porifera / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry
D047028:Macrocyclic Compounds; D009636:Norbornanes; D011760:Pyrrolidinones; C009435:tetramic acid