title: Distribution-based and anchor-based approaches provided different interpretability estimates for the Hydrocephalus Outcome Questionnaire.
abstract: OBJECTIVE
  To compare three separate methods for establishing interpretability for a health status measure, the Hydrocephalus Outcome Questionnaire (HOQ).
  
  
  METHODS
  The mothers of children with hydrocephalus attending the outpatient clinics at a pediatric hospital completed the HOQ (for which scores can range from 0 to 1.0 with the smallest possible incremental change being .005), the Health Utilities Index-2 (HUI-2), and a global rating of their child's health. The surgeon for the child also provided a global rating of the child's health following their visit. These data were used to calculate (i) the minimal important difference (MID) based on global health ratings, (ii) the MID based on an effect size approach, and (iii) the conversion of numerical HOQ scores into health utility scores obtained from the HUI-2.
  
  
  RESULTS
  Based on mothers' responses (n = 79) and surgeons' responses (n = 61), respectively, the MID for the HOQ was estimated to be .12 and .10. Using the effect size approach, the MID was estimated to be much lower at .03. HOQ scores were found to be readily translatable to HUI-2 utility scores using a simple linear transformation. The mean utility score for this sample of patients was .77.
  
  
  CONCLUSIONS
  Two methods for determining the MID yielded quantitatively different results. Conversion of numerical health status scores to utility scores was done successfully and providing another element of interpretability.
authors.affiliation: Department of Population Health Sciences and Division of Neurosurgery, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. abhaya.kulkarni@sickkids.on.ca
authors.forename: Abhaya V
authors.initials: AV
authors.lastname: Kulkarni
mesh_terms: D003627:Data Interpretation, Statistical; D006305:Health Status Indicators; D006801:Humans; D006849:Hydrocephalus / Q000628:therapy*; D016014:Linear Models; D009035:Mothers; D011795:Surveys and Questionnaires; D016896:Treatment Outcome