Solid-phase approach to tetrahydroquinolones using a sulfur linker cleaved by SmI2.
[reaction: see text] A sulfur alpha-heteroatom-substituted carbonyl (HASC) linker has been utilized in a solid-phase approach to tetrahydroquinolones. The route illustrates the compatibility of the linker system with palladium-catalyzed transformations and its utility for library synthesis. The linker is cleaved by electron transfer from samarium(II) iodide.
Turner
Kristy L
KL
The School of Chemistry, University of Manchester, UK.
Baker
Thomas M
TM
Islam
Saidul
S
Procter
David J
DJ
Stefaniak
Mark
M