Ramadan fasting induces modifications of certain serum components in obese women with type 2 diabetes.
OBJECTIVE
To examine the effect of fasting during Ramadan on certain serum components such as fasting serum glucose (FSG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TGs), high density lipoproteins (HDL-C), and low density lipoproteins (LDL-C) parameters in obese women patients with type 2 diabetes.


METHODS
We conducted the study in Petit-Vichy Diabetology Center, Sidi-Bel-Abbes, Algeria from October 2003 to March 2004, on 60 obese outpatient women (BMI = 35.41 +/- 3.64 kg/m2), aged 51 +/- 10 years, who had diabetes for 5 +/- 2.5 years. The patients followed no specific diet, on medications, and presenting no degenerative complications. We carried out the study over 3 periods: before (pre-fasting), during (fasting), and after Ramadan month (post-fasting).


RESULTS
Comparing Ramadan (fasting period) with non-Ramadan days (pre- and post-fasting periods), we observed significant decreases in FSG (16.72%, p<0.001), in HbA1c (11.3%, p<0.005), and in HDL-C (26.81%, p<0.001) rates, while TC (13.85%, p<0.001), TGs (16.9%, p<0.003), and the LDL-C (22.39%, p<0.0001) levels increased significantly.


CONCLUSIONS
These findings show a beneficial effect of fasting during Ramadan on glucose homeostasis, however, we observed an unbalanced profile on lipids.
Khaled
Boumediene M
BM
Department of Biology, Faculty of Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria.
Bendahmane
Malika
M
Belbraouet
Slimane
S
D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D005215:Fasting; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007514:Islam; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D012068:Religion and Medicine; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D014280:Triglycerides