title: A clinically relevant contact allergy to methyldibromo glutaronitrile at 1% (0.32 mg/cm) detected by a patch test.
abstract: Recently, the preservative methyldibromo glutaronitrile (MDBGN) at 0.5% w/w in petrolatum was included in the European standard patch test series based on the studies on chemical stability and consideration of rates of contact allergy, doubtful and irritant reactions as well as information on clinical relevance represented by results of a repeated open application test (ROAT) and patch test concentrations required to diagnose allergic contact dermatitis from MDBGN in individual cases. In this report, a case with a clinically relevant contact allergy to MDBGN, which on the mandatory reading occasion on D3 only was traced by a patch test with MDBGN at 1.0% (0.32 mg/cm2), is presented. The patient suffered from a chronic hand dermatitis, and when the patient stopped using a liquid soap containing MDBGN, the hand dermatitis substantially improved. A ROAT performed in a blinded and controlled way with applications twice daily on the hands with 2 moisturizers with and without MDBGN resulted in a deterioration of the hand dermatitis on the hand to which the MDBGN-preserved moisturizer had been applied.
authors.affiliation: Department of Occupational and Environmental Dermatology, Lund University, University Hospital, Malmö, Sweden. magnus.bruze@med.lu.se
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
authors.forename: Birgitta
authors.initials: B
authors.lastname: Gruvberger
authors.forename: Erik
authors.initials: E
authors.lastname: Zimerson
mesh_terms: D000485:Allergens / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D006229:Hand Dermatoses / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D010328:Patch Tests
chemical_list: D000485:Allergens; D009570:Nitriles; C039411:1,2-dibromo-2,4-dicyanobutane