[Alkaloids from the root of Lindera angustifolia].
OBJECTIVE
To study the alkaloid constituents of the root of Lindera angustifolia Cheng.


METHODS
The constituents were isolated and purified by column chromatography and the structures were characterized by spectral analysis.


RESULTS
Seven aporphine alkaloids, laurotetanine (I), N-methyllaurotetanine (II), boldine (III), isoboldine (IV), norboldine (V), N-ethoxycarbonyllaurotetanine (VII) and a quaternary isoquinoline alkaloid, magnocurarine (VI), were isolated and identified. The structure of VII was further identified by semi-synthesis with I as starting material.


CONCLUSIONS
All compounds were obtained from this plant for the first time and compound VII was found as a naturally occurring compound for the first time.
Zhao
Qi-Zhi
QZ
Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China.
Zhao
Yi-Min
YM
Wang
Ke-Jun
KJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification*; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification; D027443:Lindera / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000470:Alkaloids; D001060:Aporphines; D007546:Isoquinolines; C048506:magnocurarine; C011686:boldine; C464744:isoboldine; C008256:laurotetanine