The molecular basis for calcium-dependent axon pathfinding.
Ca(2+) signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca(2+) influx and release from stores by guidance cues shapes Ca(2+) signals, which determine the activation of downstream targets. Although the precise molecular mechanisms that underlie distinct Ca(2+)-mediated effects on growth cone behaviours remain unclear, recent studies have identified important players in both the regulation and targets of Ca(2+) signals in growth cones.
Gomez
Timothy M
TM
Department of Anatomy, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA. tmgomez@wisc.edu
Zheng
James Q
JQ
D000818:Animals; D001369:Axons / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000235:genetics*; D020439:Growth Cones / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology*
D002118:Calcium