[Study of bone mineral density in complete androgen insensitivity syndrome patients].
OBJECTIVE
To explore the characteristics and treatment of bone mineral density (BMD) change in complete androgen insensitivity syndrome (CAIS) of Chinese patients.


METHODS
Fourteen cases of CAIS were studied retrospectively through analyzing and comparing BMD of pre- and post-orchidectomy with normal Chinese men and women. BMD at the lumbar spine and the femur were measured by dual energy X-ray absorptiometry (DXA).


RESULTS
Ten cases of CAIS had pre-orchidectomy DXA, in which 6 cases had very significantly reduced L(2-4) BMD (0.92 +/- 0.08) g/cm(2) compared with normal men and women (P < 0.01). Five cases had significantly reduced femur neck BMD (0.89 +/- 0.12) g/cm(2) compared with normal male (P < 0.05). Seven cases had 12 post-orchidectomy DXA, in which all L(2-4) BMD (0.95 +/- 0.06) g/cm(2) were very significantly reduced compared with normal male and female (P < 0.01), femur neck BMD (0.91 +/- 0.08) g/cm(2) was also significantly reduced compared with normal male (P < 0.01) and normal female (P < 0.05).


CONCLUSIONS
There are different degrees of osteopenia in patients of CAIS, especially in lumbar vertebra. This suggests that estrogen and androgen play important roles in the acquirement and maintenance of bone mass.
Tian
Qin-jie
QJ
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
Dai
Zhi-qin
ZQ
Yu
Wei
W
Tian
Jun-Ping
JP
Lang
Jing-he
JH
D000293:Adolescent; D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000378:metabolism*; D015519:Bone Density; D016022:Case-Control Studies; D002648:Child; D004967:Estrogens / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies
D004967:Estrogens