title: Normothermic beating heart surgery with assistance of miniaturized bypass systems: the effects on intraoperative hemodynamics and inflammatory response.
abstract: The use of miniaturized cardiopulmonary bypass (CPB) circuits and avoidance of cardioplegic arrest are attempts to reduce the inflammatory response to cardiac surgery. We studied the effects of beating heart surgery (BHS) with assistance of simplified bypass systems (SBS) on global hemodynamics, myocardial function and the inflammatory response to CPB. We hypothesized that the use of SBS was associated with less hemodynamic instability after CPB resulting from attenuation of the inflammatory response when compared with surgery performed with a conventional CPB (cCPB) circuit. Forty-five patients undergoing coronary artery bypass grafting were prospectively studied. Fifteen patients were randomized to the use of a cCPB circuit, cold crystalloid cardioplegia, and moderate hypothermia. Two groups of 15 patients underwent BHS during normothermia with assistance of two different SBS consisting of only blood pump and oxygenator. Hemodynamic variables were assessed with transpulmonary thermodilution and transesophageal echocardiography. Plasma levels of proinflammatory and antiinflammatory mediators were measured perioperatively. After CPB, variables of global hemodynamics and systolic ventricular function did not differ among groups. Left ventricular diastolic function was impaired after CPB equally in all groups (P < 0.01 versus pre-CPB). At the end of surgery, there was more need for vasopressor (norepinephrine) support in both SBS groups than in the cCPB group (P < 0.01). After CPB, the release of interleukin (IL)-6 did not differ significantly among groups, whereas plasma levels of IL-10 were higher in the cCPB group (P < 0.01 versus SBS). The extent of myocardial necrosis (Troponin T) was comparable in all groups. We conclude that in our study, miniaturizing bypass systems and avoidance of cardioplegic arrest were not effective in improving hemodynamic performance and in attenuating the proinflammatory immune response after CPB.
authors.affiliation: Department of Anesthesiology, Universitätsklinikum der RWTH, Aachen, Germany. srex@ukaachen.de
authors.forename: Steffen
authors.initials: S
authors.lastname: Rex
authors.forename: Stefan
authors.initials: S
authors.lastname: Brose
authors.forename: Sebastian
authors.initials: S
authors.lastname: Metzelder
authors.forename: Lothar
authors.initials: L
authors.lastname: de Rossi
authors.forename: Sylvia
authors.initials: S
authors.lastname: Schroth
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Autschbach
authors.forename: Rolf
authors.initials: R
authors.lastname: Rossaint
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Buhre
mesh_terms: D000758:Anesthesia; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation; D006439:Hemodynamics; D006801:Humans; D007036:Hypothermia, Induced; D018836:Inflammation Mediators / Q000097:blood*; D008875:Middle Aged; D008904:Miniaturization; D016343:Monitoring, Intraoperative; D017680:Potassium Compounds
chemical_list: D018836:Inflammation Mediators; D017680:Potassium Compounds; C018369:potassium cardioplegic solution