title: Acetates and benzoates of alkyl catechols and evaluation of their antibacterial activity.
abstract: Potential biologically active alkyl catechol esters were prepared and their antibacterial activity was determined against 12 Gram-positive and 16 Gram-negative bacteria. Esterification (acetylation and benzoylation) of mono-, di- and tetra- substituted alkyl catechols afforded the di-acetyl and di-benzoyl derivatives in each case. In the primary screening it was observed that the substitution of hydroxyl group in alkyl catechol with an acyl group generally resulted in a decrease of antibacterial activity. A number of acetyl and benzoyl derivatives inhibited the growth of Salmonella typhi. In case of Gram-positive bacteria only di-O-benzoyl-3,5,6,-tetra-(3-hexyl) catechol (26) showed a significant activity.
authors.affiliation: H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: B S
authors.initials: BS
authors.lastname: Siddiqui
authors.forename: S
authors.initials: S
authors.lastname: Begum
authors.forename: Q
authors.initials: Q
authors.lastname: Adil
authors.forename: M
authors.initials: M
authors.lastname: Akber
authors.forename: S
authors.initials: S
authors.lastname: Firdous
authors.forename: K A
authors.initials: KA
authors.lastname: Khan
authors.forename: S A
authors.initials: SA
authors.lastname: Khan
authors.forename: S M
authors.initials: SM
authors.lastname: Khalid