title: Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan.
abstract: OBJECTIVE
  To investigate the relationship between the metabolic syndrome and its related factors among non-diabetic pre- and post-menopausal women in North Taiwan.
  
  
  METHODS
  A cross-sectional study in a medical center in North Taiwan.
  
  
  METHODS
  Five hundred and ninety-four, non-diabetic middle-aged women (age range=40-64 years, mean=48.9+/-5.4 years) were recruited.
  
  
  METHODS
  The fasting plasma glucose, insulin, lipids levels and anthropometric indices were measured. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMA-IR). Metabolic syndrome was defined by using the National Cholesterol Education Panel (NCEP) criteria and modified NCEP criteria (waist circumference >80 cm).
  
  
  RESULTS
  The prevalence of metabolic syndrome was 6.2% using NCEP criteria, and 8.9% using modified NCEP criteria. Post-menopausal women had a higher prevalence of metabolic syndrome and its individual components compared to pre-menopausal women except hyperglycemia and low HDL-C. In multiple logistic regression analysis with adjustment for age and menopausal status, both BMI and HOMA-IR were independently associated with the metabolic syndrome.
  
  
  CONCLUSIONS
  The prevalence of metabolic syndrome was higher in post-menopausal than pre-menopausal women. Both obesity and insulin resistance may play an important role in the development of metabolic syndrome among the middle-aged women in North Taiwan.
authors.affiliation: Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: W-Y
authors.initials: WY
authors.lastname: Lin
authors.forename: W-S
authors.initials: WS
authors.lastname: Yang
authors.forename: L-T
authors.initials: LT
authors.lastname: Lee
authors.forename: C-Y
authors.initials: CY
authors.lastname: Chen
authors.forename: C-S
authors.initials: CS
authors.lastname: Liu
authors.forename: C-C
authors.initials: CC
authors.lastname: Lin
authors.forename: K-C
authors.initials: KC
authors.lastname: Huang
mesh_terms: D000328:Adult; D000886:Anthropometry; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000208:ethnology; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids