title: Association between an estrogen receptor alpha gene polymorphism and the risk of prostate cancer in black men.
abstract: OBJECTIVE
  Studies suggest that SNPs within ESR1 may be associated with an increased risk of prostate cancer. We evaluated the association of the XbaI and PvuII ESR1 SNPs and prostate cancer risk in 3 different racial/ethnic populations.
  
  
  METHODS
  A total of 1,603 volunteers from the SABOR study (285 black, 876 white and 442 Hispanic men) were genotyped to assess allelic frequencies of the ESR1 SNPs. Case-control analysis was performed on 598 prostate cancer cases and 1,098 controls (260 black men, 1,013 non-Hispanic white men and 423 Hispanic white men) to assess the association between these polymorphisms and prostate cancer risk.
  
  
  RESULTS
  Allelic frequency was significantly different across ethnic/racial groups for both SNPs. Logistic regression analysis adjusted for age and stratified by race and ethnicity demonstrated an association between the AG genotype or presence of the G allele (GG or AG genotype) in the XbaI SNP and prostate cancer risk within black men (OR 2.25, 95% CI 1.07-4.70, p = 0.031; OR 2.14, 95% CI 1.05-4.35, p = 0.035, respectively). No association was observed among Hispanic and non-Hispanic white men for this SNP. Furthermore, there was no association between the PvuII SNP and prostate cancer risk across all groups.
  
  
  CONCLUSIONS
  Our study demonstrates an association between the AG genotype, as well as presence of the G allele within the XbaI ESR1 SNP and prostate cancer risk among black men.
authors.affiliation: Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Hernández
authors.forename: Ivana
authors.initials: I
authors.lastname: Balic
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Johnson-Pais
authors.forename: Betsy A
authors.initials: BA
authors.lastname: Higgins
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Torkko
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Leach
mesh_terms: D000368:Aged; D044383:Black People; D015257:DNA-Cytosine Methylases / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005787:Gene Frequency; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000235:genetics*; D044465:White People
chemical_list: D047628:Estrogen Receptor alpha; C047084:DNA modification methylase PvuII; C059639:DNA modification methylase XbaI; D015257:DNA-Cytosine Methylases; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)