Determination of trace platinum by supramolecular catalytic kinetic spectrofluorimetry of beta-cyclodextrin-platinum-KBrO3-salicylaldehyde furfuralhydrazone.
A supramolecular catalytic kinetic spectrofluorimetric method was developed for the determination of platinum(IV) and the possible mechanism of catalytic reaction was discussed. The method was based on the fluorescence-enhancing reaction of salicylaldehyde furfuralhydrazone (SAFH) with potassium bromate, which was catalysed by platinum(IV) in a water-ethanol medium. beta-Cyclodextrin (beta-CD) obviously sensitized the determination at pH 5.20 and 25 degrees C. Under optimum conditions, the beta-CD-platinum-KBrO3-SAFH supramolecular kinetic catalytic reaction system had excitation and emission maxima at 372 and 461 nm, respectively. The linear range of this method was 0.60-180 ng ml-1 with a relative standard deviation of 1.2%, and the detection limit was 0.18 ng ml-1. Investigation of the mechanism and the effects of interferences is presented. The proposed method was applied successfully to determine trace platinum(IV) in the chemotherapeutic drug cisplatin and serum from patients with satisfactory results.
Tang
Bo
B
College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, 250014, People's Republic of China. tangb@sdnu.edu.cn
Zhang
Ning
N
Chen
Zhen-Zhen
ZZ
Kong
Qing-Cheng
QC