title: [Study on treatment effectiveness and safety in children with chronic hepatitis B or C using bicyclo tablets].
abstract: BACKGROUND
  To evaluate treatment effectiveness and safety of bicyclo tablets in children with chronic hepatitis B or C.
  
  
  METHODS
  A randomized controlled trial was conducted in 148 children with chronic hepatitis B or C for evaluating safety, tolerability, and efficacy of treatment with bicyclo tablets or Hugan tablets. Children in therapy group were treated with bicyclo tablets and control group treated with Hugan tablets.
  
  
  RESULTS
  (1) ALT and AST level decreased more prominently in therapy group than in control group (P<0.01). (2) Bicyclo was more effective than Hugan tablets (P<0.01). (3) Symptoms were ameliorated more prominently in bicyclo group than in control group (P<0.01). (4) Both groups had no significant adverse events.
  
  
  CONCLUSIONS
  Satisfactory therapeutic effect and safety were obtained with bicyclo tablets in children with chronic hepatitis B or C.
authors.affiliation: Department of Pediatric Liver Disease, The No. 302 Hospital of The People's Liberation Army, Beijing 100039, China.
authors.forename: Hong-fei
authors.initials: HF
authors.lastname: Zhang
authors.forename: Xiao-jin
authors.initials: XJ
authors.lastname: Yang
authors.forename: Shi-shu
authors.initials: SS
authors.lastname: Zhu
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Chen
authors.forename: Wen-zheng
authors.initials: WZ
authors.lastname: Jia
authors.forename: Yu
authors.initials: Y
authors.lastname: Gan
authors.forename: Li-min
authors.initials: LM
authors.lastname: Wang
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D001713:Biphenyl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D013607:Tablets; D016896:Treatment Outcome
chemical_list: D001713:Biphenyl Compounds; D013607:Tablets; C477843:bicyclol