title: Dendrimers for pharmaceutical and biomedical applications.
abstract: Dendrimers are a unique class of synthetic macromolecules having a highly branched, three-dimensional, nanoscale architecture with very low polydispersity and high functionality. Structural advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. This review discusses several aspects of dendrimers, including preparation, dendrimer-drug coupling chemistry, structural models of dendrimer-based drug delivery systems, and physicochemical and toxicological properties.
authors.affiliation: School of Pharmacy, University of Wisconsin-Madison, WI 53705, USA.
authors.forename: Hu
authors.initials: H
authors.lastname: Yang
authors.forename: Weiyuan John
authors.initials: WJ
authors.lastname: Kao
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D050091:Dendrimers / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D008954:Models, Biological; D008970:Molecular Weight; D049329:Nanostructures
chemical_list: D050091:Dendrimers; D004337:Drug Carriers