title: Additive contribution of multiple factors in the development of pneumatosis intestinalis: a case report and review of the literature.
abstract: We describe a 53-year-old patient with dermatomyositis, who developed pneumatosis intestinalis (PI) accompanied by pneumoperitoneum, pneumoretroperitoneum, pneumomediastinum, and subcutaneous emphysema of the neck. The development of PI in our patient was possibly attributed to the effect of factors such as dermatomyositis, corticosteroids, methotrexate, and alpha-glucosidase inhibitor (AGI). The coexistence of multiple factors associated with PI might enhance the risk of developing PI, even though each of them alone is not sufficient to induce it. In particular, the use of AGIs for patients treated with immunosuppressive agents such as corticosteroids requires evaluation.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, 160-8582 Tokyo, Japan. fwpg4063@mb.infoweb.ne.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Saito
authors.forename: Akiko
authors.initials: A
authors.lastname: Tanikawa
authors.forename: Katsuki
authors.initials: K
authors.lastname: Nakasute
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Takeji
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D007294:Inositol / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D011006:Pneumatosis Cystoides Intestinalis / Q000209:etiology* / Q000628:therapy
chemical_list: D000305:Adrenal Cortex Hormones; D007004:Hypoglycemic Agents; D007294:Inositol; C102817:voglibose