Pediatric primary leptomeningeal lymphoma treated without cranial radiotherapy.
We report a case of primary leptomenigeal lymphoma (PLML) in an 11-year-old boy presenting with headache, vomiting, and diplopia. The patient was treated on an advanced non-Hodgkin lymphoma protocol with systemic/intrathecal chemotherapy without cranial radiotherapy. He remains in complete remission 33 months after treatment.
Taga
Takashi
T
Department of Pediatrics, Shiga University of Medical Science, Ohtsu, Shiga, Japan. ttaga@belle.shiga-med.ac.jp
Sakaue
Yuko
Y
Anzai
Yuko
Y
Takeuchi
Yoshihiro
Y
Ohta
Shigeru
S
D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics / Q000648:ultrastructure; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004172:Diplopia / Q000209:etiology; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D005158:Facial Paralysis / Q000209:etiology; D006261:Headache / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D008228:Lymphoma, Non-Hodgkin / Q000737:chemistry / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D008727:Methotrexate / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D014178:Translocation, Genetic; D014750:Vincristine / Q000008:administration & dosage
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D003561:Cytarabine; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; C027260:pirarubicin; D006854:Hydrocortisone; D008727:Methotrexate