Epitheliotropic cutaneous lymphoma (mycosis fungoides) in a dog.
A seven-year-old castrated male Yorkshire terrier dog was presented for a recurrent skin disease. Erythematous skin during the first visit progressed from multiple plaques to patch lesions and exudative erosion in the oral mucosa membrane. Biopsy samples were taken from erythematous skin and were diagnosed with epitheliotropic T cell cutaneous lymphoma by histopathology and immunochemical stain. In serum chemistry, the dog had a hypercalcemia (15.7 mg/dl) and mild increased alkaline phosphatase (417 U/l). Immunohistochemistry was performed to detect parathyroid hormone-related peptide (PTH-rP) in epitheliotropic cutaneous lymphoma tissues but the neoplastic cells were not labeled with anti-PTH-rP antibodies. The patient was treated with prednisolone and isotretinoin. However, the dog died unexpectedly.
Bhang
Dong Ha
DH
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
Choi
Ul Soo
US
Kim
Min Kyu
MK
Choi
Eun-Hwa
EH
Kang
Min-Soo
MS
Hwang
Cheol-Yong
CY
Kim
Dae-Yong
DY
Youn
Hwa Young
HY
Lee
Chang Woo
CW
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D015474:Isotretinoin / Q000627:therapeutic use; D008297:Male; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D011239:Prednisolone; D015474:Isotretinoin