Idiopathic sclerosing orbital pseudotumor in seven cats.
OBJECTIVE
To review the clinical presentation and histopathologic findings on a series of cats with orbital fibrotic disease and compare the data to that of humans with sclerosing orbital pseudotumor.


METHODS
A retrospective study was undertaken, which identified tissue samples from seven cats between 1997 and 2002 with a history of orbital mass effect and pathology characterized by fibrous tissue proliferation.


METHODS
Information was obtained from medical records for affected cats, including age, sex, clinical signs, management, and outcome, with histopathology re-examined.


RESULTS
Six of seven cats presented with unilateral orbital involvement that progressed to bilateral orbital disease despite treatment. Onset was insidious, evolving over weeks to months and was associated with fixation of orbital structures. Owners of six of the cats opted for euthanasia because of disease progression and pain. Histopathology of affected orbital tissue included extensive fibrosis with encapsulation of normal tissues without characteristics of neoplasia.


CONCLUSIONS
Clinical findings and histopathology of globes and orbital tissues in cats bore many similarities to idiopathic sclerosing orbital pseudotumor in humans. In cats, the prognosis for the globe appears to be poor but an elucidation of the pathogenesis and earlier diagnosis coupled with more aggressive treatment modalities as indicated in humans may be beneficial.
Billson
F Mark
FM
Division of Small Animal Clinical Studies, Department of Veterinary Clinical Studies, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow, G61 1QH, UK. fmbills2002@yahoo.com.au
Miller-Michau
Tammy
T
Mould
John R B
JR
Davidson
Michael G
MG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy / Q000473:pathology*; D002415:Cats; D018450:Disease Progression; D037901:Euthanasia, Animal; D007150:Immunohistochemistry / Q000662:veterinary; D009916:Orbital Diseases / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D016727:Orbital Pseudotumor / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D011241:Prednisone