title: Relationship between IL-10 and tumor markers in breast cancer patients.
abstract: Tumor markers are expressed due to molecular alterations of the tumor cells, and we can relate them to the immune system to find new associations to improve prognosis. IL-10 inhibits the generation of immune responses at the tumor site. To determine IL-10 expression in the tumor microenvironment and to associate it with certain tumor markers, 27 breast cancer patients were monitored by immunohistochemistry. The results showed that 23 breast cancer samples exhibited a strong expression of IL-10. IL-10 was associated with some poor prognosis tumor makers. A direct association between IL-10, Bcl-2, and Bax was detected. The relationship between IL-10 and Bax was statistically significant (P=0.001). An inverse association of IL-10 with p53 was observed. IL-10 reflects a suppressive tumor microenvironment, and its relationship with apoptosis markers can suggest an increase in the aggressiveness of the tumor even if it still is at an early stage.
authors.affiliation: Instituto Nacional de Oncología y Radiobiología, 29 y F, Vedado, Ciudad de la Habana cp 10400, Cuba. llanesleticia@yahoo.com.mx
authors.forename: Leticia
authors.initials: L
authors.lastname: Llanes-Fernández
authors.forename: Rosa Irene
authors.initials: RI
authors.lastname: Alvarez-Goyanes
authors.forename: Maria Del Carmen
authors.initials: Mdel C
authors.lastname: Arango-Prado
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Alcocer-González
authors.forename: Julia Cruz
authors.initials: JC
authors.lastname: Mojarrieta
authors.forename: Xiomara Escobar
authors.initials: XE
authors.lastname: Pérez
authors.forename: Maiby Orozco
authors.initials: MO
authors.lastname: López
authors.forename: Sonia Franco
authors.initials: SF
authors.lastname: Odio
authors.forename: Rolando
authors.initials: R
authors.lastname: Camacho-Rodríguez
authors.forename: Marta Elena
authors.initials: ME
authors.lastname: Guerra-Yi
authors.forename: Vicente
authors.initials: V
authors.lastname: Madrid-Marina
authors.forename: Reyes
authors.initials: R
authors.lastname: Tamez-Guerra
authors.forename: Cristina
authors.initials: C
authors.lastname: Rodríguez-Padilla
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000276:immunology; D018270:Carcinoma, Ductal, Breast / Q000097:blood; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood; D011960:Receptors, Estrogen / Q000097:blood; D016159:Tumor Suppressor Protein p53 / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D016753:Interleukin-10; D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D016159:Tumor Suppressor Protein p53