[The effect of erythropoetin on doxorubicin-induced oxidative stress in rat kidney].
The early nephrotoxicity manifestations (oxidative stress) caused by a single administration of doxorubicin in rats and the therapeutic effect of erythropoietin have been studied. The introduction of doxorubicin leads to a decrease in the concentration of glutathione and the activity of glutathione reductase in rat kidneys, which is indicative of the development of oxidative stress. Erythropoietin restores glutathione content on the normal level. The pretreatment with erythropoietin reduces the doxorubicin induced damage in rat kidneys.
Saenko
Iu V
IuV
Shutov
A M
AM
Napalkova
S M
SM
Selivanova
O S
OS
Evstegneeva
E Iu
EIu
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004921:Erythropoietin / Q000008:administration & dosage*; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000293:injuries / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats
D000903:Antibiotics, Antineoplastic; D004921:Erythropoietin; D004317:Doxorubicin; D005978:Glutathione