Acetylcholinesterase effects on glutamate receptors.
We studied acetylcholinesterase (AChE) effects on glutamate receptors (GluR) in rat brain sections, synaptosomal membranes and cultured hippocampal neurones. A selective potentiation of AMPA receptors (AMPAR) binding in AMPAR-enriched layers undergoing synaptogenesis plus an increased surface expression of synaptic clusters of GluR1, GluR2, and SV2a was found. Thus, the AMPAR synaptic recruitment induced by AChE, could be a molecular mechanism underlying its non-classical synaptogenic actions.
Olivera Bravo
Silvia
S
Molecular Neuroscience Unit, Instituto Clemente Estable, Av. Italia 3318, Montevideo 11600, Uruguay.
Henley
Jeremy
J
Rodriguez-Ithurralde
Daniel
D
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017470:Receptors, Glutamate / Q000378:metabolism*
D017470:Receptors, Glutamate; D000110:Acetylcholinesterase