Systemic immunological response to exercise in patients with chronic obstructive pulmonary disease: what does it mean?
Chronic obstructive pulmonary disease (COPD) is no longer seen as a pulmonary disease, but is increasingly associated with systemic effects with important clinical relevance. Systemic immunological changes in COPD patients are characterized by an increased number of circulating inflammatory cells, functional changes of the inflammatory cells, elevated plasma levels of cytokines, and oxidative stress. Physical exercise induces an abnormal systemic inflammatory and oxidative response in COPD patients, which is seen in both the circulation and the peripheral muscles. Although mechanisms and consequences of these effects are not yet fully understood, they could be harmful in COPD patients by inducing damage or functional changes in, for example, skeletal muscles. Whether these changes of the immune system can also affect the susceptibility to infections in these patients is unknown. The concept of COPD as a systemic rather than only a pulmonary disease also opens new perspectives on the development for new therapeutic interventions. The effects of new antioxidative and anti-inflammatory agents are investigated. A better understanding of the complexity of the systemic effects will aid the development of new therapies and management strategies for patients with COPD.
van Helvoort
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Department of Pulmonary Diseases and Institute for Fundamental and Clinical Human Movement Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. H.vanHelvoort@long.umcn.nl
Heijdra
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D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D004198:Disease Susceptibility; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007239:Infections / Q000276:immunology; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology* / Q000503:physiopathology* / Q000628:therapy; D012138:Respiratory Therapy
D000893:Anti-Inflammatory Agents; D000975:Antioxidants