Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor.
Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A(2) and A(4) showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.
Liu
Yan
Y
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Xu
Yufang
Y
Qian
Xuhong
X
Xiao
Yi
Y
Liu
Jianwen
J
Shen
Liyun
L
Li
Junhui
J
Zhang
Yuanxing
Y
D000073:Acenaphthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D014408:Biomarkers, Tumor; D015687:Cell Hypoxia / Q000187:drug effects*; D002478:Cells, Cultured / Q000187:drug effects; D006224:Cricetinae; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000494:pharmacology*; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism
D000073:Acenaphthenes; D014408:Biomarkers, Tumor; D003517:Cyclopentanes; D005456:Fluorescent Dyes; D009570:Nitriles; D010100:Oxygen