Lingering mysteries of ubiquitin-chain assembly.
The small protein ubiquitin is often linked to substrates as a polymer. Such polymers vary in both linkage and length, which has important consequences for their function. Surprisingly, the mechanisms of ubiquitin-chain assembly are still not known. Deciphering them will shed light on why substrates differ in the extent and timing of polyubiquitin modification and how ancillary ubiquitination factors function.
Hochstrasser
Mark
M
Yale University, Department of Molecular Biophysics & Biochemistry, New Haven, CT 06520, USA. mark.hochstrasser@yale.edu
D001665:Binding Sites / Q000502:physiology; D008958:Models, Molecular; D025801:Ubiquitin / Q000096:biosynthesis* / Q000737:chemistry / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry / Q000502:physiology
D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes