Choroidal dye filling velocity in patients with Vogt-Koyanagi-Harada disease.
OBJECTIVE
To evaluate quantitative choroidal dye filling velocity in patients with Vogt-Koyanagi-Harada disease (VKH) before and after corticosteroid treatment using indocyanine green (ICG) angiography.


METHODS
ICG angiography was performed in seven VKH patients before and after systemic corticosteroid treatment. Choroidal dye curves were obtained by image analysis software and analyzed using an exponential model. The model's time constant (tau) was used to evaluate choroidal dye filling velocity.


RESULTS
Compared with controls, acute phase choroidal tau values in VKH patients were significantly longer, suggesting choroidal circulation disturbance. During the recovery phase, choroidal tau values were significantly shortened, suggesting choroidal circulatory disturbance improvement.


CONCLUSIONS
Choroidal dye filling velocity may be useful for VKH diagnosis and verification of corticosteroid treatment effectiveness.
Mawatari
Yuki
Y
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
Hirata
Akira
A
Fukushima
Mikiko
M
Tanihara
Hidenobu
H
D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use; D001775:Blood Circulation / Q000502:physiology*; D001783:Blood Flow Velocity; D002829:Choroid / Q000098:blood supply*; D004396:Coloring Agents; D004359:Drug Therapy, Combination; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D014607:Uveomeningoencephalitic Syndrome / Q000188:drug therapy / Q000503:physiopathology*
D004396:Coloring Agents; D005938:Glucocorticoids; D001623:Betamethasone; D011239:Prednisolone; D007208:Indocyanine Green