A randomised placebo-controlled trial of prolonged prednisolone administration to patients with HELLP syndrome remote from term.
OBJECTIVE
To evaluate the effect of prolonged administration of high-dose prednisolone on early onset HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome during expectant management.


METHODS
A randomized, double-blind trial was performed in 31 pregnant women with HELLP syndrome with an onset before 30 weeks gestation. Patients received either 50mg prednisolone or placebo intravenously twice a day. Primary outcome measures were the entry-to-delivery interval and the number of recurrent HELLP exacerbations in the antepartum period.


RESULTS
Serious maternal morbidity was considerable, in particular in the placebo group where even on maternal occurred as a consequence of liver rupture. The mean entry-delivery interval did not differ between the prednisolone group (6.9 days) and the placebo group (8.0 days). However, patients in the prednisolone group had a significant lower risk of a recurrent HELLP exacerbation after the initial crisis had subsided, as compared to patients in the placebo group (HR 0.3, with 95% CI 0.3-0.9). Platelet count recovered faster in the prednisolone group as compared to the placebo group (mean 1.7 days versus 6.2 days, P<0.01).


CONCLUSIONS
HELLP syndrome remote from term causes high risk for serious maternal morbidity and mortality. When expectant management is pursued in selected patients with a HELLP syndrome remote from term, prolonged administration of prednisolone reduces the risk of recurrent HELLP syndrome exacerbations.
van Runnard Heimel
Pieter J
PJ
Department of Perinatology and Gynaecology, University Medical Centre Utrecht, Utrecht, The Netherlands. heimel@hotmail.com
Huisjes
Anjoke J M
AJ
Franx
Arie
A
Koopman
Corine
C
Bots
Michiel L
ML
Bruinse
Hein W
HW
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005865:Gestational Age; D017359:HELLP Syndrome / Q000188:drug therapy*; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage*; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects*; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second / Q000187:drug effects; D012008:Recurrence
D000893:Anti-Inflammatory Agents; D011239:Prednisolone