Synthesis and antifungal activity of 6-hydroxycinnolines.
6-Hydroxycinnolines 2 and cyclohexa-2,5-diene-1,4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6-Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2,5-diene-1,4-diones. The results suggest that 6-hydroxycinnolines would be potent antifungal agents.
Ryu
Chung-Kyu
CK
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@mm.ewha.ac.kr
Lee
Jung Yoon
JY
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure
D000935:Antifungal Agents; D006574:Heterocyclic Compounds, 2-Ring; C476282:cinnoline