title: Pilot study to determine the efficacy of ALA-PDT photo-rejuvenation for the treatment of facial ageing.
abstract: OBJECTIVE
  The study was divided into two parts. The objective of the preliminary study was to evaluate the optimum dose and tolerance of 5-aminolaevulinic acid (5-ALA) compared to a placebo cream with a 633-nm LED light in normal, healthy, volunteer forearm skin. The second study was to establish if ALA-PDT treatments improve the signs of ageing.
  
  
  RESULTS
  Threshold photosensitization was observed using 5% 5-ALA under plastic occlusion for 30 minutes following a dose response study of forearm skin. Mild improvement was observed, using this concentration and time, for periorbital skin aging. Other anecdotal positive results of photo-rejuvenation are reported for facial and chest areas.
authors.affiliation: Cranley Clinic, London, UK. cranleyuk@aol.com
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Lowe
authors.forename: Philippa
authors.initials: P
authors.lastname: Lowe
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005123:Eye; D005542:Forearm; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D010865:Pilot Projects; D012060:Rejuvenation; D015595:Skin Aging; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid