title: The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysis.
abstract: BACKGROUND
  No clear consensus has been reached yet on how best to characterize children who suffer from pediatric bipolar disorder (PBD). The CBCL-PBD profile on the Child Behavior Checklist (CBCL) has been consistently reported showing deviant findings on the Attention Problems, Aggressive Behavior, and Anxious-Depressed subscales.
  
  
  OBJECTIVE
  To examine the sensitivity and specificity of the proposed CBCL-PBD profile for determining DSM diagnosis of PBD.
  
  
  METHODS
  We applied receiver operating characteristic (ROC) curve analysis to data from 471 probands from two family studies of attention-deficit hyperactivity disorder and their 410 siblings.
  
  
  RESULTS
  The CBCL-PBD score demonstrated an area under the curve (AUC) of 0.97 for probands and 0.82 for siblings for current diagnosis of PBD, suggesting that the CBCL-PBD provided a highly efficient way of identifying subjects with a current diagnosis of PBD in this sample.
  
  
  CONCLUSIONS
  These findings suggest that the CBCL-PBD may provide a highly efficient way of screening for childhood bipolar disorder.
authors.affiliation: Medical Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA. faraones@upstate.edu
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Robert R
authors.initials: RR
authors.lastname: Althoff
authors.forename: James J
authors.initials: JJ
authors.lastname: Hudziak
authors.forename: Michael
authors.initials: M
authors.lastname: Monuteaux
authors.forename: Joseph
authors.initials: J
authors.lastname: Biederman
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D001714:Bipolar Disorder / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D002648:Child; D002653:Child Behavior Disorders / Q000150:complications / Q000175:diagnosis*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005192:Family Health; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D010552:Personality Assessment; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D035781:Siblings