Sertraline delays the somatic growth and reflex ontogeny in neonate rats.
This study investigated the somatic maturation and ontogeny of reflexes in neonate rats treated with sertraline (Sert) during the suckling period. The animals were divided into four groups; three that received daily doses of Sert (5, 10 or 15 mg/kg s.c.; groups Sert5, Sert10, and Sert15, respectively), and a fourth group that received distilled water (Dw) (1 ml/kg/b.w.). Growth indicators (body weight, axis of the head and tail length) were measured daily, from the 1st to the 21st postnatal day. The reflexes (righting, free-fall righting, negative geotaxis, cliff avoidance, auditory startle response, vibrissa placing and palm grasp) and physical-feature maturation (ear unfolding, auditory conduit opening, irruption of the lower incisors and eye opening) were recorded each day of the animal's life. All groups were compared to the Dw group. The body weight gain was reduced in all the Sert groups. Moreover, a delay in the growth of the body length was observed in all the Sert groups. Higher Sert doses reduced the speed of growth in the tail length. The medio-lateral head axis reduced in Sert15 and Sert5 doses. Otherwise, Sert10 had a temporary acceleration in this growth, but the growth of the anteroposterior head axis had a delay in all the Sert groups. The highest doses induced a delay in physical-feature maturation. The palm grasp reflex (disappearance) was retarded in Sert10; cliff avoidance advanced in Sert10; negative-geotaxis and free-fall righting retarded in Sert15. The findings suggest that altered serotonergic system activity induced by sertraline early in life could play a role in the retardation of the somatic growth ontogeny as well as a delay in the maturation of some reflexes.
Deiró
T C B J
TC
Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Pernambuco (UFPE), Av. Morais Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Manhães-de-Castro
R
R
Cabral-Filho
J E
JE
Barreto-Medeiros
J M
JM
Souza
S L
SL
Marinho
S M O C
SM
Castro
F M M
FM
Toscano
A E
AE
Jesus-Deiró
R A
RA
Barros
K M F T
KM
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000833:Animals, Suckling; D001835:Body Weight / Q000187:drug effects; D006128:Growth / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D020280:Sertraline / Q000494:pharmacology*
D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline