title: Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma.
abstract: OBJECTIVE
  To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects.
  
  
  METHODS
  MnSOD genotypes were determined by PCR with subsequent restriction analysis by the BsaWI enzyme.
  
  
  RESULTS
  Significant differences in allele frequencies between groups were not ascertained.
  
  
  CONCLUSIONS
  Pursuant to these results, Ala-9Val polymorphism does not seem to be a significant predisposing factor for bronchial asthma in the Czech population.
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Masaryk University Brno, Komenskeho nam. 2, 662 43 Brno, Czech Republic. holla@med.muni.cz
authors.forename: Lydie Izakovicova
authors.initials: LI
authors.lastname: Holla
authors.forename: Katerina
authors.initials: K
authors.lastname: Kankova
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
mesh_terms: D000328:Adult; D000483:Alleles; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D013482:Superoxide Dismutase