title: Primary squamous cell carcinoma in unreconstructed exstrophic bladder.
abstract: Bladder exstrophy is associated with an increased incidence of primary adenocarcinoma of the bladder. We report a rare case of squamous cell carcinoma occurring in the unreconstructed, exstrophic bladder of a 53-year-old woman treated with radical cystectomy and radiochemotherapy. This case represents the oldest patient to present with squamous cell carcinoma of an unreconstructed exstrophic bladder. We discuss the potential mechanisms of carcinogenesis in this patient, noting how they may potentially differ from those in a patient with a reconstructed bladder.
authors.affiliation: Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Jocelyn Mary Delia
authors.initials: JM
authors.lastname: Rieder
authors.forename: J Kellogg
authors.initials: JK
authors.lastname: Parsons
authors.forename: John P
authors.initials: JP
authors.lastname: Gearhart
authors.forename: Mark
authors.initials: M
authors.lastname: Schoenberg
mesh_terms: D001746:Bladder Exstrophy / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000150:complications*