Treatment of cervical dystonia with botulinum toxins.
Botulinum toxin (BoNT) treatment has been used extensively for the treatment of cervical dystonia. In most studies, there is significant improvement following treatment for head posture and pain. The common side effects following treatment include dysphagia, dry mouth, and neck weakness. There are five brands and two serotypes of BoNT available. The dosing of each serotype and brand differs. Perhaps more importantly, each brand and serotype may differ in immunogenic potential and occurrence of secondary unresponsiveness, an issue that is currently under active investigation. Although many aspects of the technique of injection have not been adequately studied, general guidelines are available.
Comella
C L
CL
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA. ccomella@rush.edu
Thompson
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PD
D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000627:therapeutic use*; D006801:Humans; D014103:Torticollis / Q000188:drug therapy*; D017211:Treatment Failure
D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins