Asymmetric synthesis of functionalized diarylmethanols catalyzed by a new gamma-amino thiol.
[reaction: see text] A mild asymmetric arylation of aromatic aldehydes catalyzed by gamma-amino thiol 5 gave the corresponding diarylmethanols with 95 to >99.5% ee.
Wu
Ping-Yu
PY
Department of Chemistry, National Tsing Hua University, Hsinchu, 300 Taiwan.
Wu
Hsyueh-Liang
HL
Uang
Biing-Jiun
BJ
D000588:Amines / Q000737:chemistry*; D007202:Indicators and Reagents; D000432:Methanol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D000588:Amines; D007202:Indicators and Reagents; D013438:Sulfhydryl Compounds; D000432:Methanol