title: Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species.
abstract: The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. The results demonstrate remarkable differences in the reactivation of inhibited brain AChE, depending on the oxime and species
authors.affiliation: Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.
authors.forename: Daniel
authors.initials: D
authors.lastname: Jun
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Jiri
authors.initials: J
authors.lastname: Cabal
authors.forename: Lucie
authors.initials: L
authors.lastname: Bartosova
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kunesova
authors.forename: Jiri
authors.initials: J
authors.lastname: Kassa
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006801:Humans; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D012524:Sarin / Q000494:pharmacology*; D013552:Swine
chemical_list: D002800:Cholinesterase Inhibitors; D010091:Oximes; D012524:Sarin; D000110:Acetylcholinesterase