title: Cytomegalovirus infection in solid organ transplant recipients: new challenges and their implications for preventive strategies.
abstract: BACKGROUND
  Late-onset CMV disease is being increasingly recognized as a significant post-transplantation complication.
  
  
  OBJECTIVE
  To discern the impact of antiviral prophylactic strategies on the emerging syndrome of late-onset CMV disease in organ transplant recipients.
  
  
  METHODS
  Review of existing reports and published data relevant to antiviral prophylaxis in organ transplant recipients.
  
  
  RESULTS
  Prevention of CMV using prophylaxis has proven effective and is widely employed in organ transplant recipients. However, late-onset CMV disease is increasingly being recognized as a significant complication in these patients. The more potent the activity of the antiviral drug and the longer duration of prophylaxis, the greater likelihood of late-onset CMV disease. CMV seronegative recipients of seropositive donor allografts appear to be at a uniquely high risk. A higher proportion of patients with late-onset CMV have tissue invasive disease. Late-onset CMV disease in liver transplant recipients conferred an independently higher risk of mortality in the first post-transplant year. Prolonged antiviral therapy may impair the recovery of CMV-specific T-cell responses. Preemptive therapy appears to be less likely to be associated with CMV disease.
  
  
  CONCLUSIONS
  Discernment of the pathophysiologic basis of late-onset CMV warrants investigation. Preemptive therapy may be the preferable approach to CMV prophylaxis.
authors.affiliation: VA Medical Center and University of Pittsburgh, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA. nis5+@pitt.edu
authors.forename: Nina
authors.initials: N
authors.lastname: Singh
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D018890:Chemoprevention; D003586:Cytomegalovirus Infections / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents