title: Malaria in a holoendemic area of Burkina Faso: a cross-sectional study.
abstract: A malaria survey of the entire population of a village in Western Burkina Faso (n=1,561) was conducted to assess malaria endemicity. The study population was examined for symptoms characteristic of malaria including fever, anaemia, splenomegaly and parasites present in thick blood films. In the overall study population, the prevalence of Plasmodium spp. infection by microscopic examination of thick blood films was 79.0% (1,233/1,561). In a subcohort with 201 individuals, PCR techniques found a prevalence rate for all Plasmodium spp. of 92.0% (185/201), while microscopy found one of 80.6% (162/201). A combination of both methods gives a rate of 95.5% (192/201). Though univariate logistic analyses of elevated body temperature, anaemia, splenomegaly and age showed them all to be predictors of or risk factors for an infection, only elevated body temperature and age were predictors in multivariate logistic analysis. However, the symptom of splenomegaly did show a highly significant association with infection by multiple species of Plasmodium.
authors.affiliation: Hygiene Institut, Abteilung Parasitologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany.
authors.forename: August
authors.initials: A
authors.lastname: Stich
authors.forename: Nadja
authors.initials: N
authors.lastname: Oster
authors.forename: Inas Z
authors.initials: IZ
authors.lastname: Abdel-Aziz
authors.forename: Gabriele
authors.initials: G
authors.lastname: Stieglbauer
authors.forename: Boubacar
authors.initials: B
authors.lastname: Coulibaly
authors.forename: Hannes
authors.initials: H
authors.lastname: Wickert
authors.forename: Jeremy
authors.initials: J
authors.lastname: McLean
authors.forename: Bocar A
authors.initials: BA
authors.lastname: Kouyaté
authors.forename: Heiko
authors.initials: H
authors.lastname: Becher
authors.forename: Michael
authors.initials: M
authors.lastname: Lanzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001769:Blood / Q000469:parasitology; D002050:Burkina Faso / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016054:DNA, Protozoan / Q000097:blood; D019353:Endemic Diseases; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D016054:DNA, Protozoan