High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele.
We examined the relation between cutaneous melanoma risk and the intercellular adhesion molecule-1 (ICAM-1) gene single nucleotide polymorphisms G241R and K469E, as well as the circulating soluble form of ICAM-1 determined in plasma, in the population of Modena Province, northern Italy. Individuals carrying at least one R241 allele, versus those carrying the wild-type GG genotype, had a relative risk of melanoma of 4.3 (P = 0.022), whereas the K469E polymorphism was unrelated to disease risk. Soluble ICAM-1 levels above 10 ng/ml directly and strongly correlated with melanoma risk. In this population, individuals carrying the R241 allele of the ICAM-1 gene appeared to show an enhanced susceptibility to cutaneous melanoma, possibly because of increased ICAM-1 expression.
Vinceti
Marco
M
Department of Public Health Sciences, University of Modena and Reggio Emilia, Modena, Italy. marco.vinceti@unimore.it
Pellacani
Giovanni
G
Casali
Bruno
B
Malagoli
Carlotta
C
Nicoli
Davide
D
Farnetti
Enrico
E
Bassissi
Stefania
S
Bergomi
Margherita
M
Seidenari
Stefania
S
D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000235:genetics*; D007558:Italy; D008545:Melanoma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics*
D018799:Intercellular Adhesion Molecule-1