title: Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus.
abstract: Ethnobotanists often utilize predictive models to analyze the potential of indigenously used medicinal plants. The most common of these prognostic models is the informant consensus model. This study evaluates use of this model through the analytical ethnopharmacology of Manus Province, Papua New Guinea (PNG). The informant consensus model enables researchers to prioritize plants for pharmacognostic evaluation, based on the relative frequency of plants cited in anthropological interviews. Fieldwork on Manus Island, PNG, led to the identification of 43 species of plants used in traditional medicine for persistent respiratory symptoms. Plants were collected, dried, micro-extracted using a new technique generated in our laboratory, and evaluated in vitro against Mycobacterium tuberculosis. The results, in the form of IC(50) values and modified selectivity indices (SI), were compared to the results of the anthropological models of informant consensus, and statistically compared through linear regression and t-tests. Results were not statistically significant (alpha=0.1), leading to the conclusions that the informant consensus assumptions were inaccurate in predicting anti-mycobacterial activity among the Manus for anti-TB claims.
authors.affiliation: Department of Medicinal Chemistry & Pharmacognosy, MC/781 College of Pharmacy, the University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Case
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: Yuehong
authors.initials: Y
authors.lastname: Wang
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Cho
authors.forename: D Doel
authors.initials: DD
authors.lastname: Soejarto
authors.forename: Guido F
authors.initials: GF
authors.lastname: Pauli
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D020834:Ethnopharmacology; D006801:Humans; D007407:Interviews as Topic; D008800:Mexico; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010219:Papua New Guinea; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018514:Plant Structures; D010946:Plants, Medicinal; D012140:Respiratory Tract Diseases / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D010936:Plant Extracts