Cladobotric acids A-F: new cytotoxic polyketides from a New Zealand Cladobotryum sp.
[reaction: see text] Cladobotric acids A-F (1-6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1-6 was concluded from feeding experiments with (13)C-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A-F (1-6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans.
Mitova
Maya I
MI
Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8020, New Zealand.
Lang
Gerhard
G
Blunt
John W
JW
Cummings
Nicholas J
NJ
Cole
Anthony L J
AL
Robinson
Ward T
WT
Munro
Murray H G
MH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020171:Botrytis / Q000737:chemistry* / Q000302:isolation & purification; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009520:New Zealand
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents