title: [Synthesis and antitumour activity of metal complexes of bacteriochlorophyll].
abstract: OBJECTIVE
  To find a new PDT sensitizer.
  
  
  METHODS
  There were four complexes (Cu, Zn, Co, Ni) synthesized through reaction of metal and deprivating-Mg bacteriochlorophyll in the organic solvent. Their antitumor action was detected by MTT.
  
  
  RESULTS
  The ultraviolet-visual spectrum and the fluorescence spectrum of these complexes showed that synthesis of these four complexes was succeeded. And these metal complexes have potent antitumor action on two kinds of leukaemic cells.
  
  
  CONCLUSIONS
  Metal bacteriochlorophylls as PDT sensitizers have very good properties and this is a way to develop new PDT sensitizers.
authors.affiliation: Institute of Modern Chemistry, Shanxi University, Taiyuan 030006, China. mlwang@sxu.edu.cn
authors.forename: Meng-Liang
authors.initials: ML
authors.lastname: Wang
authors.forename: Ru-Bo
authors.initials: RB
authors.lastname: Chang
authors.forename: Dian-Sheng
authors.initials: DS
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001429:Bacteriochlorophylls / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D018922:HL-60 Cells / Q000166:cytology; D006801:Humans; D020014:K562 Cells / Q000166:cytology; D019216:Metals, Heavy / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001429:Bacteriochlorophylls; D019216:Metals, Heavy; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc