Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection.
OBJECTIVE
To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI).


METHODS
A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neonates with risk factors, but without EOBI, served as controls. LBP, C-reactive protein (CRP) and interleukin-8 (IL-8) were determined.


RESULTS
LBP in the noninfected group increased until 24 h after birth (P < 0.05 vs 6 h). LBP and CRP correlated strongly in neonates with suspected EOBI (r = 0.63). Although LBP reached a higher sensitivity than CRP 6 and 12 h after clinical suspicion (45 (24-68) and 79% (54-94) vs 9 (0-24) and 39% (17-64); P < 0.05)), EOBI was most reliably detected by IL-8.


CONCLUSIONS
LBP kinetics were age-dependent. LBP was not sufficiently sensitive in the prediction of EOBI.
Orlikowsky
T W
TW
Department of Neonatology, University Children's Hospital, Tübingen, Germany.
Trüg
C
C
Neunhoeffer
F
F
Deperschmidt
M
M
Eichner
M
M
Poets
C F
CF
D000209:Acute-Phase Proteins / Q000032:analysis / Q000378:metabolism*; D001424:Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism*; D002352:Carrier Proteins / Q000032:analysis / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis / Q000378:metabolism*; D011237:Predictive Value of Tests; D011336:Probability; D012372:ROC Curve; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D015415:Biomarkers; D002097:C-Reactive Protein; D002352:Carrier Proteins; D016209:Interleukin-8; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein