[Comparing serum tumor antigen detection combined with CT scan with PET-CT for lung cancer diagnosis].
OBJECTIVE
Positron emission tomography-computed tomography (PET-CT) is a new bio-imaging system which combined metabolic with anatomic imaging. This system has better three-dimensional definition and earlier tumor detection potential. This study was to compare the accuracy of tumor antigen detection combined with CT scan with PET-CT for lung cancer diagnosis and staging.


METHODS
A total of 43 lung cancer patients diagnosed by operation or acupuncture, received breast CT scan, tumor antigen detection, and PET-CT scan, were selected. The accuracies of these 2 methods and their impacts on lung cancer staging were compared.


RESULTS
The accurate diagnosis rate of tumor antigen detection combined with CT scan was 67.44%, and that of PET-CT scan was 90.70%. Local focus detection rates were 86.05% and 95.35%, respectively; mediastinal lymph nodes detection rates were 65.12% and 83.72%, respectively. PET-CT detected 6 cases of distant metastasis which were not detected by tumor antigen detection combined with CT scan. Compared with CT scan, 5 (11.63%) cases were upstaged and 7 (16.28%) cases were downstaged by PET-CT, which led to therapeutic strategy changes in 4 (9.3%) cases.


CONCLUSIONS
Compare with tumor antigen detection combined with CT scan, PET-CT scan is more sensitive and accurate in diagnosing and staging lung cancer.
Zhang
Xia
X
Department of Oncology, Nanjing Command Fuzhou General Hospital, Fuzhou, Fujian 350025, P. R. China.
Li
Tian-Ran
TR
Chen
Zhang-Shu
ZS
Ouyang
Xue-Nong
XN
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
D000951:Antigens, Neoplasm