[Abnormalities of haemostasis in myocardial infarction with normal coronary artery].
Myocardial infarction with normal coronary artery is ussually inaugural, with electric and clinical characteristics similar to those with atheroma. The role of constitutional or acquired abnormalities of haemostasis has been more incriminated in the pathogenesis of myocardial infarction with normal coronary. The aim of our study was to research abnormalities of haemostasis in patients with myocardial infarction and angiographically absolutely normal coronary arteries.


METHODS
Thirty nine patients with myocardial infarction and normal coronary arteries where included in our study. They were 33 males and 6 females aged between 22 and 75 years (44 + 13 years), in whom the deficiency in protein C and S. antithrombin, activated protein C resistance and antiphospholipid antibodies were assessed.


RESULTS
Concurrent abnormalities of haemostasis were found in 10 patients: Antiphospholipid antibodies, found in 5 patients constitute the most frequent abnormality. The other abnormalities were deficiency in protein C in two cases, deficiency in protein S 2 cases, deficiency in antithrombin in 2 ceses and activated protein C resistance in 3 cases .


CONCLUSIONS
In our study. in face of the high prevalence of these abnormalities, it seems reasonable to research them, especially in young patients with myocardial infarction with normal coronary artery. This should have an impact on the management of these patients.
Mohsen
Hassine
H
Laboratoire d'hématologie, E.P.S Fattouman Bourguiba de Monastír.
Faouzi
Addad
A
Khaldoun
Ben Hamda
BH
Fatma
Abderrazak
A
Hanéne
Hmida
H
Zohra
Dridi
D
Habib
Gamr
G
Fethi
Betbout
B
Faouzi
Maatouk
M
Mohamed
Ben Farhat
BF
D020016:Activated Protein C Resistance / Q000175:diagnosis; D000328:Adult; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000097:blood; D000991:Antithrombins / Q000032:analysis / Q000172:deficiency; D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging; D011486:Protein C / Q000032:analysis; D020151:Protein C Deficiency / Q000175:diagnosis; D017293:Protein S / Q000032:analysis; D018455:Protein S Deficiency / Q000175:diagnosis; D012189:Retrospective Studies
D017152:Antibodies, Antiphospholipid; D000991:Antithrombins; D007074:Immunoglobulin G; D011486:Protein C; D017293:Protein S