Stem cells, tissue engineering and organogenesis in transplantation.
Tissue engineering is an attempt to generate living tissues for surgical transplantation. In vitro and in vivo approaches have led to the production of vascular and cardiovascular components, bones, cartilages and gastrointestinal tissues. Organogenesis has a different aim, which is to create transplantable organs from embryonic tissue implanted into the recipient's omentum. This approach has been successful in creating kidneys and pancreases in animals. The use of stem cells in organogenesis and in tissue engineering has vastly enlarged the potential for clinical applications. The technique of nuclear transfer offers the possibility of creating cells, which are genetically identical to the host. Tissue engineering and organogenesis represent the future of transplantation in medicine. The progress in this field is of tremendous importance because it can produce a new generation of morphologically complex tissues and organs. In this review, the most relevant experiences in this area are summarized, including its perspectives for therapeutical applications.
Cortesini
Raffaello
R
Columbia University, 630 West 168th Street-P&S 14-401, New York, NY 10032, USA. rc238@columbia.edu
D000818:Animals; D006801:Humans; D038081:Organogenesis / Q000276:immunology*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D014181:Transplantation Immunology