Acrokeratosis paraneoplastica of Bazex as an indicator for underlying squamous cell carcinoma of the lung.
OBJECTIVE
Obligatory cutaneous paraneoplastic disorders comprising acanthosis nigricans maligna, erythema gyratum repens, paraneoplastic pemphigus, hypertrichosis lanuginosa acquisita, erythema necrolyticum migrans and acrokeratosis paraneoplastica are rare. However, as markers of an underlying internal malignancy they are of utmost importance for the patient. Acrokeratosis paraneoplastica (first described by Gougerot and Rupp in 1922) was named after Bazex who had then reported several cases in a French dermatological journal since 1965 (Bazex et al. in Bull Soc Fr Dermatol Syphiligr 72:182, 1965; Bazex and Griffiths in Br J Dermatol 102:301-306, 1980).


METHODS
The study is a clinical case of a patient with acrokeratosis paraneoplastica.


RESULTS
the patient was later diagnosed with a cervical lymph node metastasis and thereafter with a primary squamous cell carcinoma of the left upper lobe and upon treatment responded with the clearing of the skin changes.


CONCLUSIONS
Identification of a paraneoplastic syndrome may enhance the earlier diagnosis of the associated tumor and may thus enable curative treatment.
Strobel
Eva-Susanne
ES
Division of Hematology and Oncology, St. Georg Vorsorge- und Rehabilitationskliniken, Kurhausplatz 1, 79862 Höchenschwand, Germany. susanne.strobel@uniklinik-freiburg.de
Bouveret
Carolin
C
Kohl
Peter Karl
PK
D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D012086:Reoperation; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome