title: Hydrochlorothiazide-induced acute non-cardiogenic pulmonary edema.
abstract: We report the case of a 64 year-old male with non cardiogenic pulmonary edema episodes after oral administration of 12.5 mg of hydrochlorothiazide. In vitro immunologic study with basophil activation test and late cellular activation study (CD69 and production of interferon gamma) with chlorothiazide were performed, and no activation was observed. As a consequence, like in previous cases published, the pathogenic mechanism remains unknown, and it probably is an idiosyncratic reaction.
authors.affiliation: Servicio de Alergología, Hospital de Basurto, Bilbao, Spain. pgamboa@hbas.osakidetza.net
authors.forename: P M
authors.initials: PM
authors.lastname: Gamboa
authors.forename: V
authors.initials: V
authors.lastname: Achotegui
authors.forename: J
authors.initials: J
authors.lastname: Irigoyen
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Asenjo
authors.forename: J
authors.initials: J
authors.lastname: Merino
authors.forename: M L
authors.initials: ML
authors.lastname: Sanz
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D004232:Diuretics / Q000009:adverse effects*; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000139:chemically induced*; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide