IL-1 can act as number one.
Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.
Gamero
Ana M
AM
Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, FCRF, Frederick, Maryland 21702, USA.
Oppenheim
Joost J
JJ
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D007375:Interleukin-1 / Q000378:metabolism*; D051379:Mice; D053594:Myeloid Differentiation Factor 88; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000378:metabolism*; D013203:Staphylococcal Infections / Q000235:genetics / Q000276:immunology*; D013211:Staphylococcus aureus
D048868:Adaptor Proteins, Signal Transducing; D007375:Interleukin-1; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D017472:Receptors, Interleukin-1