Large, nonhealing scalp ulcer associated with scarring alopecia and sclerodermatous change in a patient with porphyria cutanea tarda.
Porphyria cutanea tarda (PCT) is a disorder caused by deficient activity of a liver enzyme that leads to the accumulation of photoactive metabolites in the skin. The initial clinical presentation commonly includes mechanical fragility of the skin and blisters in sun-exposed areas. Sclerodermatous skin changes and scarring alopecia are described in up to 20% of patients. Although these unique skin changes have been reported in the literature, information regarding nonhealing ulcers of extraordinary size is lacking. We report a unique cutaneous manifestation of PCT that is not well documented: unusually large, nonhealing ulcers in the setting of sclerodermatous skin changes and scarring alopecia.
Inglese
Marc J
MJ
Department of Medicine, University of Florida, Gainesville 32610, USA. inglese@ufl.edu
Bergamo
Bethany M
BM
D000410:Alanine Transaminase / Q000032:analysis; D000505:Alopecia / Q000150:complications*; D001219:Aspartate Aminotransferases / Q000032:analysis; D001799:Blood Sedimentation; D002921:Cicatrix / Q000150:complications*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D017119:Porphyria Cutanea Tarda / Q000150:complications / Q000175:diagnosis*; D012535:Scalp; D012594:Scleroderma, Localized / Q000150:complications*; D012883:Skin Ulcer / Q000150:complications*
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase