title: Caffeine in the milk prevents respiratory disorders caused by in utero caffeine exposure in rats.
abstract: Consequences of postnatal caffeine exposure by the milk on ponto-medullary respiratory disturbances observed following an in utero caffeine exposure were analysed. Ponto-medullary-spinal cord preparations from newborn rats exposed to caffeine during gestation but not after the birth display an increase in respiratory frequency and an exaggeration of the hypoxic respiratory depression compared to not treated preparations. These data suggest that tachypneic and apneic episodes encountered in human newborns whose mother consumed caffeine during pregnancy are due in large part to central effect of caffeine at the ponto-medullary level. Both baseline respiratory frequency increase and emphasis of hypoxic respiratory depression are not encountered if rat dams consumed caffeine during nursing. Our hypothesis is that newborn rats exposed to caffeine during gestation but not after the birth would be in withdrawal situation whereas, when caffeine is present in drinking fluid of lactating dams, it goes down the milk and is able to prevent ponto-medullary respiratory disturbances.
authors.affiliation: Laboratoire de Dysrégulations Métaboliques Acquises et Génétiques, UPRES EA 3901, Faculté de Médecine, Université de Picardie Jules Verne, 3 rue des Louvels, 80036 Amiens Cedex 1, France. laurence.bodineau@u-picardie.fr
authors.forename: Laurence
authors.initials: L
authors.lastname: Bodineau
authors.forename: Fadoua
authors.initials: F
authors.lastname: Saadani-Makki
authors.forename: Hugues
authors.initials: H
authors.lastname: Jullien
authors.forename: Alain
authors.initials: A
authors.lastname: Frugière
mesh_terms: D000818:Animals; D002110:Caffeine / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D005260:Female; D000860:Hypoxia / Q000188:drug therapy; D008892:Milk; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012120:Respiration Disorders / Q000209:etiology / Q000517:prevention & control*; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine