Evaluation of CD7 and terminal deoxynucleotidyl transferase (TdT) expression in CD34+ myeloblasts from patients with myelodysplastic syndrome.
There is an emerging use of flow cytometry to evaluate patients with myelodysplastic syndrome (MDS). We have studied CD7 and TdT expression in the CD34+ myeloid blast cell population in 55 bone marrow samples of patients with MDS. CD7 and/or TdT were detected in 38 out of 55 patients (69%). CD7 expression was not related to other bad prognosis data but conversely, we found an association between TdT+ CD34 myeloblasts and high-risk MDS patients according to the International Prognostic Scoring System. Therefore, CD7 and TdT may help to establish the diagnosis of MDS and, TdT expression also seems to be a useful marker in distinguishing risk groups.
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Department of Haematology, Clínica Moncloa, Madrid, Spain.
Subirá
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D
Mtnez-Chamorro
C
C
Castañón
S
S
Arranz
E
E
Ramiro
S
S
Gil-Fernández
J J
JJ
López-Pascual
J
J
Alonso
A
A
Pérez-Sáenz
M A
MA
Alaez
C
C
Renedo
M
M
Blas
C
C
Escudero
A
A
Fdez-Rañada
J M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000096:biosynthesis*; D019011:Antigens, CD7 / Q000032:analysis / Q000096:biosynthesis*; D020732:Cytogenetic Analysis; D004253:DNA Nucleotidylexotransferase / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D042381:Granulocyte Precursor Cells / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000276:immunology*; D012307:Risk Factors; D015996:Survival Rate
D018952:Antigens, CD34; D019011:Antigens, CD7; D004253:DNA Nucleotidylexotransferase