Recognition of secondary structures in proteins by a diiron(III) complex via a hydrolytic pathway.
The diiron(III) complex Fe(2)(DTPB)(mu(2)-O)(mu(2)-OAc)Cl(BF(4))(2) [DTPB = 1,1,4,7,7-pentakis(2'-benzimidazol-2-yl-methyl)triazaheptane, OAc = acetate] exhibits a similar affinity for proteins belonging to different structural patterns. However, this diiron complex is sensitive to secondary structures in a protein when it is used to promote the protein hydrolysis, indicating that some metal complexes, such as artificial proteolytic agents, could become a new hydrolytic probe of protein structures.
Pan
Qunhui
Q
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
Jiang
Wei
W
Liao
Zhanru
Z
Zhang
Tianle
T
Liu
Changlin
C
D005290:Ferric Compounds / Q000737:chemistry*; D006868:Hydrolysis; D007501:Iron / Q000737:chemistry*; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
D005290:Ferric Compounds; D009942:Organometallic Compounds; D011506:Proteins; C511459:diiron(III)(1,1,4,7,7-pentakis(2'-benzimidazol-2-ylmethyl)triazaheptane)(mu2-O)(mu2-OAc); D007501:Iron