title: An exposure assessment for selected pharmaceuticals within a watershed in Southern Ontario.
abstract: Recent studies from a number of countries have shown that measurable concentrations of both human and veterinary pharmaceuticals can be found in a variety of environmental matrices such as surface and ground water, soils, and sediments. Few data are available that characterize the sources, exposure and effects of pharmaceuticals in the environment and there is clearly a need to define these parameters within a Canadian context. We present in this paper the first report in southern Ontario, Canada on the geographic and temporal distribution of pharmaceuticals detected within seven tributaries receiving primarily agricultural inputs in a typical watershed. Of the 28 pharmaceuticals surveyed, 14 were detected in the streams sampled (n=125). Temporal trends in concentration for five frequently detected pharmaceuticals show pulses occurring between May and November of 2003 at similar but varying times over the seasons, depending on the pharmaceuticals, flow rate, and precipitation. Fluctuations in concentration of ions indicative of agricultural run off, such as nitrate and phosphate, were not found to be useful predictors of changes in pharmaceutical concentration (P>0.4), however a significant correlation between dissolved organic carbon and monensin and carbamazepine concentrations were observed (P<0.013). Exposure profiles illustrating concentration distributions for three of the more prevalent pharmaceuticals detected, including lincomycin, monensin and carbamazepine, showed a log normal distribution, useful for calculating centiles of environmental concentrations. While distributions of estimated total potency of pharmaceuticals detected in the surface waters suggested small risks of environmental effects of mixtures to daphnia, green algae, Lemna gibba, and fish, the significance of non-target effects and impacts due to chronic low level exposures to chemical mixtures remains unclear.
authors.affiliation: Department of Environmental Biology, Bovey Building, Gordon Street, University of Guelph, Guelph, Ont., Canada N1G 2W1. llissemo@lsd.uoguelph.ca
authors.forename: Linda
authors.initials: L
authors.lastname: Lissemore
authors.forename: Chunyan
authors.initials: C
authors.lastname: Hao
authors.forename: Paul
authors.initials: P
authors.lastname: Yang
authors.forename: Paul K
authors.initials: PK
authors.lastname: Sibley
authors.forename: Scott
authors.initials: S
authors.lastname: Mabury
authors.forename: Keith R
authors.initials: KR
authors.lastname: Solomon
mesh_terms: D000818:Animals; D002170:Canada; D000460:Chlorophyta / Q000187:drug effects* / Q000254:growth & development; D003621:Daphnia / Q000187:drug effects* / Q000254:growth & development; D064420:Drug-Related Side Effects and Adverse Reactions; D004784:Environmental Monitoring; D005399:Fishes; D007220:Industrial Waste / Q000009:adverse effects / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis; D045483:Rivers / Q000737:chemistry; D012621:Seasons; D012722:Sewage / Q000009:adverse effects / Q000032:analysis; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis; D014881:Water Supply
chemical_list: D007220:Industrial Waste; D004364:Pharmaceutical Preparations; D012722:Sewage; D014874:Water Pollutants, Chemical