Thermosensitive and mucoadhesive delivery systems of mucosal vaccines.
Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers.
Han
In-Kwon
IK
MyGene Bioscience Institute, Kangnam-gu, Seoul, Republic of Korea. ikhan@mygene.net
Kim
Young Bong
YB
Kang
Hung-Sik
HS
Sul
Donggeun
D
Jung
Woon-Won
WW
Cho
Hee Jeong
HJ
Oh
Yu-Kyoung
YK
D000180:Acrylic Resins / Q000737:chemistry; D000281:Administration, Intranasal; D000282:Administration, Intravaginal; D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D000941:Antigens / Q000737:chemistry; D036022:Capsid Proteins / Q000737:chemistry / Q000276:immunology; D002772:Cholera Toxin / Q000737:chemistry / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005782:Gels / Q000737:chemistry; D018928:Immunity, Mucosal / Q000276:immunology*; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000737:chemistry; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000276:immunology; D011060:Poloxalene / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012212:Rheology; D044366:Transition Temperature; D014611:Vaccination / Q000379:methods*; D014621:Vagina / Q000276:immunology / Q000378:metabolism
D000180:Acrylic Resins; D000941:Antigens; D036022:Capsid Proteins; D005782:Gels; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D009856:Oncogene Proteins, Viral; D011092:Polyethylene Glycols; C063317:L1 protein, Human papillomavirus type 16; C030312:calcium polycarbophil; D011060:Poloxalene; D002772:Cholera Toxin