title: Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study.
abstract: BACKGROUND
  Reducing aspiration of gastric contents by placing mechanically ventilated patients in a semirecumbent position has been associated with lower incidences of ventilator-associated pneumonia (VAP). The feasibility and efficacy of this intervention in a larger patient population, however, are unknown.
  
  
  OBJECTIVE
  Assessment of the feasibility of the semirecumbent position for intensive care unit patients and its influence on development of VAP.
  
  
  METHODS
  In a prospective multicentered trial, critically ill patients undergoing mechanical ventilation were randomly assigned to the semirecumbent position, with a target backrest elevation of 45 degrees , or standard care (i.e., supine position) with a backrest elevation of 10 degrees .
  
  
  METHODS
  Backrest elevation was measured continuously during the first week of ventilation with a monitor-linked device. A deviation of position was defined as a change of the randomized position >5 degrees . Diagnosis of VAP was made by quantitative cultures of samples obtained by bronchoscopic techniques.
  
  
  RESULTS
  One hundred nine patients were assigned to the supine group and 112 to the semirecumbent group. Baseline characteristics were comparable for both groups. Average elevations were 9.8 degrees and 16.1 degrees at day 1 and day 7, respectively, for the supine group and 28.1 degrees and 22.6 degrees at day 1 and day 7, respectively, for the semirecumbent group (p < .001). The target semirecumbent position of 45 degrees was not achieved for 85% of the study time, and these patients more frequently changed position than supine-positioned patients. VAP was diagnosed in eight patients (6.5%) in the supine group and in 13 (10.7%) in the semirecumbent group (NS), after a mean of 6 (range, 3-9) and 7 (range, 3-12) days, respectively. There were no differences in numbers of patients undergoing enteral feeding, receiving stress ulcer prophylaxis, or developing pressure sores or in mortality rates or duration of ventilation and intensive care unit stay between the groups.
  
  
  CONCLUSIONS
  The targeted backrest elevation of 45 degrees for semirecumbent positioning was not reached in the conditions of the present randomized study. The achieved difference in treatment position (28 degrees vs. 10 degrees ) did not prevent the development of VAP.
authors.affiliation: University Hospital Maastricht, Department of Intensive Care Medicine.
authors.forename: Christianne A
authors.initials: CA
authors.lastname: van Nieuwenhoven
authors.forename: Christine
authors.initials: C
authors.lastname: Vandenbroucke-Grauls
authors.forename: Frank H
authors.initials: FH
authors.lastname: van Tiel
authors.forename: Hans C A
authors.initials: HC
authors.lastname: Joore
authors.forename: Rob J M Strack
authors.initials: RJ
authors.lastname: van Schijndel
authors.forename: Ingeborg
authors.initials: I
authors.lastname: van der Tweel
authors.forename: Graham
authors.initials: G
authors.lastname: Ramsay
authors.forename: Marc J M
authors.initials: MJ
authors.lastname: Bonten
mesh_terms: D018806:APACHE; D003422:Critical Care / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000209:etiology / Q000517:prevention & control*; D012121:Respiration, Artificial / Q000009:adverse effects*; D016683:Supine Position