title: Apoptosis in the hair follicle.
abstract: Apoptosis plays an important role in many physiological processes, ranging from morphogenetic events to adult tissue homeostasis, and defects in its regulation contribute to many disorders. Here we review molecular mechanisms of apoptosis in the hair follicle (HF), whose cyclical growth pattern is repeatedly interrupted by apoptosis-driven involution (catagen). We review the common mechanisms underlying apoptosis in the HF during catagen, as well as differences in the regulation of apoptosis between distinct HF cell populations. An overview is provided on the expression and function of molecules involved in the control of various phases of the apoptotic process during catagen.
authors.affiliation: Gillette Technology Center, Needham, Massachusetts 02492, USA. natasha_botchkareva@gillet.com
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Botchkareva
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Ahluwalia
authors.forename: Douglas
authors.initials: D
authors.lastname: Shander
mesh_terms: D000818:Animals; D017209:Apoptosis; D018859:Hair Follicle / Q000166:cytology* / Q000254:growth & development*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology; D008544:Melanocytes / Q000166:cytology / Q000502:physiology; D010587:Phagocytosis