A method to produce evolving functional connectivity maps during the course of an fMRI experiment using wavelet-based time-varying Granger causality.
Functional magnetic resonance imaging (fMRI) is widely used to identify neural correlates of cognitive tasks. However, the analysis of functional connectivity is crucial to understanding neural dynamics. Although many studies of cerebral circuitry have revealed adaptative behavior, which can change during the course of the experiment, most of contemporary connectivity studies are based on correlational analysis or structural equations analysis, assuming a time-invariant connectivity structure. In this paper, a novel method of continuous time-varying connectivity analysis is proposed, based on the wavelet expansion of functions and vector autoregressive model (wavelet dynamic vector autoregressive-DVAR). The model also allows identification of the direction of information flow between brain areas, extending the Granger causality concept to locally stationary processes. Simulation results show a good performance of this approach even using short time intervals. The application of this new approach is illustrated with fMRI data from a simple AB motor task experiment.
Sato
João Ricardo
JR
Institute of Mathematics and Statistics, University of São Paulo, Rua do Matão, 1010, Cidade Universitária, CEP 05508-090, São Paulo, S.P., Brazil. jsato@imc.usp.br
Junior
Edson Amaro
EA
Takahashi
Daniel Yasumasa
DY
de Maria Felix
Marcelo
M
Brammer
Michael John
MJ
Morettin
Pedro Alberto
PA
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015233:Models, Statistical; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D012016:Reference Values; D012044:Regression Analysis
D010100:Oxygen