Effect of naproxen on the pharmacokinetic parameters of rifampicin.
The effect of naproxen (500 mg) on the pharmacokinetics of rifampicin (450 mg) was evaluated in healthy human subjects (n = 10). Subjects participated in a two way crossover trial, the first dosing condition was rifampicin alone (control), and the second dosing condition was naproxen with rifampicin. The concentrations of rifampicin from the serum samples were determined by HPLC. The pharmacokinetic parameters indicated a significant (P < 0.05) increase in elimination rate constant (Ke), clearance (Cl), volume of distribution (Vd), while significant decrease in the mean residence time (MRT), and area under the concentration-time curve (AUC). Insignificant increase and decrease in absorption rate constant (Ka), and elimination half-life (t1/2), time for maximum concentration (Tmax), maximum drug concentration (Cmax) respectively was observed.
Ansari
M T
MT
Department of Pharmacy, Bahaudin Zakaria University, Multan.
Loothar
B A
BA
Khan
Q J
QJ