title: Diacylglycerol-enriched structured lipids containing CLA and capric acid alter body fat mass and lipid metabolism in rats.
abstract: OBJECTIVE
  The present study compared the effect of corn oil, diacylglycerol (DG) oil, and DG-enriched structured lipids (SL-DG) produced from corn oil, capric and conjugated linoleic acid on adiposity in rats fed an AIN-76 diet (5% fat) for 6 weeks.
  
  
  METHODS
  The plasma and hepatic lipids, adipose tissue weight, and enzyme activities related to fatty acid metabolism were determined.
  
  
  RESULTS
  The weights of the epididymal white adipose tissue (WAT), perirenal WAT, and interscapular WAT were significantly lower in the SL-DG group than in the DG group. Reduction of fat mass in the SL-DG group was related to suppressing fatty acid synthase activities and enhancing beta-oxidation activity in perirenal WAT. The plasma leptin was lower in the SL-DG group than in the DG group, plus a lower plasma TG level was accompanied by an increase in adipocyte LPL activity. Meanwhile the SL-DG supplement lowered the plasma and hepatic cholesterol level. In addition, the hepatic HMG-CoA reductase and ACAT activities were significantly lower in the SL-DG group than in the other groups.
  
  
  CONCLUSIONS
  The DG-enriched SL used in this study was effective in enhancing triglyceride metabolism in adipose tissue, especially as regards reducing the abdominal fat mass and cholesterol metabolism in the liver.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Ki-Teak
authors.initials: KT
authors.lastname: Lee
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Seon-Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003314:Corn Oil; D003652:Decanoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D004075:Diglycerides / Q000008:administration & dosage / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000378:metabolism; D020738:Leptin / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D003652:Decanoic Acids; D004075:Diglycerides; D020738:Leptin; D044243:Linoleic Acids, Conjugated; D014280:Triglycerides; C031071:decanoic acid; D003314:Corn Oil; D064429:Fatty Acid Synthases; D008071:Lipoprotein Lipase