Persistent impaired glucose tolerance has similar rate of risk factors as for diabetes--results of Indian diabetes prevention programme (IDPP).
OBJECTIVE
To determine the occurrence of persistent impaired glucose tolerance (IGT) (two times OGTT positive) and to compare the physical and clinical characteristics with subjects having transient IGT or diabetes.


METHODS
Nondiabetic subjects aged 35-55 years were screened (n=10,839, M:W 8667:2172) using 2h capillary blood glucose. IGT was diagnosed in 1332 (12.3%). Among them, 1025 (77%) responded for a second OGTT and 531 subjects (51.8%) had persistent IGT. Biochemical, demographic and anthropometric characteristics were compared among the normal (NGT, 30.1%), IGT and diabetic subjects (DM, 18%) at second GTT.


RESULTS
All had similar age. BMI, waist circumference and body fat percentage were lower in NGT than in IGT and diabetes. IGT and diabetes had similar characteristics. Family history of diabetes was the highest in persistent IGT.


CONCLUSIONS
Among the screened subjects, 1 in 20 had persistent IGT. Subject with persistent IGT had higher rates of risk factors for diabetes, such as high BMI, waist circumference and body fat percentage.
Ramachandran
A
A
M.V. Hospital for Diabetes, Diabetes Research Centre, WHO Collaborating Centre for Research, Education & Training in Diabetes, Royapuram, Chennai 600013, India. ramachandran@mvdiabetes.com
Snehalatha
C
C
Mukesh
B
B
Simon
Mary
M
Kumar
C K Sathish
CK
Vijay
V
V
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000209:etiology*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D001786:Blood Glucose