Immunocytochemical study of glycine receptors in the retina of the frog Xenopus laevis.
The expression of glycine receptors in the retina of clawed frog, Xenopus laevis was studied immunocytochemically. Glycine receptors (GlyRs), as revealed by means of several different antibodies, were mainly distributed in the inner (IPL) and the outer plexiform layers. Their composition was determined to include alpha2 and alpha3 subunits. Typical punctate appearance and specific lamination in the IPL were seen with each of the antibodies directed against the different GlyRs' subunits. A notion for diversity of the glycine receptors was put forward, according to which the alpha2 and alpha3 subunits are located in different subtypes of glycine synapses.
Vitanova
Lily
L
Department of Physiology, Medical University, 1, G.Sofiisky str., 1431 Sofia, Bulgaria. lilyvita@abv.bg
D000818:Animals; D007150:Immunohistochemistry; D021122:Protein Subunits / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D018009:Receptors, Glycine / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D012160:Retina / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism*; D014982:Xenopus laevis
D021122:Protein Subunits; D018009:Receptors, Glycine