title: Temporary diabetes mellitus secondary to a primary pancreatic Burkitt lymphoma.
abstract: Primary pancreatic lymphoma (PPL) is a rare form of extranodal lymphoma. So far, only in adults has a coincidence with diabetes mellitus (DM) been described. We report a nearly 9-year-old German boy presenting with a Burkitt lymphoma associated with a temporary insulin-dependent DM and exocrine insufficiency of the pancreas. After the patient went into remission, a spontaneous recovery of the endocrine pancreatic function was observed. On immunophenotyping, the lymphoma cells revealed expression of FasL suggesting a potentially apoptotic effect on pancreatic tissue. Beta cell impairment may have been caused by FasL resembling autoimmune diabetes.
authors.affiliation: Hospital for Children and Adolescents, University of Leipzig Medical Center, Leipzig, Germany.
authors.forename: Constance
authors.initials: C
authors.lastname: Meier
authors.forename: Thomas
authors.initials: T
authors.lastname: Kapellen
authors.forename: Ralph B
authors.initials: RB
authors.lastname: Tröbs
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hirsch
authors.forename: Reto
authors.initials: R
authors.lastname: Parwaresch
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
authors.forename: Dieter
authors.initials: D
authors.lastname: Körholz
mesh_terms: D002051:Burkitt Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000209:etiology*; D053222:Fas Ligand Protein; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012075:Remission, Spontaneous; D048069:Tumor Necrosis Factors / Q000378:metabolism
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D048069:Tumor Necrosis Factors