title: Necrobiotic xanthogranuloma.
abstract: A 67-year-old man presented with a 13-year history of slowly enlarging yellow-red plaques on the face and lower extremity. A biopsy specimen was consistent with necrobiotic xanthogranuloma. Necrobiotic xanthogranuloma is a slowly progressive histiocytic disease that is associated with paraproteinemia in most cases; however, its pathogenesis remains unclear. Although there is no first-line therapy, anecdotal reports have shown variable benefit with chemotherapeutic agents.
authors.affiliation: Department of Dermatology, New York University School of Medicine, USA.
authors.forename: Sue Ann
authors.initials: SA
authors.lastname: Wee
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Shupack
mesh_terms: D000368:Aged; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D008297:Male; D017441:Necrobiotic Disorders / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*; D014973:Xanthomatosis / Q000473:pathology*