Two cases of systemic lupus erythematosus complicated with colonic ulcers.
We report two cases of systemic lupus erythematosus (SLE) complicated with colonic ulcerations. One patient was successfully cured by steroid therapy, while the other did not respond to steroid but oral mesalazine was effective. Systemic lupus erythematosus is frequently accompanied by gastrointestinal symptoms, but colonic lesions are quite rare, and the regular treatment is not fixed yet. The high-dose steroidal regimen may be effective for microvasculitis, although it may increase the risk of perforated ulcer of the intestinal tract, which is a life-threatening complication. Further analysis of its outcomes, and establishment of the regular guideline for its treatment are expected.
Miyahara
Shoko
S
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
Ito
Satoshi
S
Soeda
Atsuko
A
Chino
Yusuke
Y
Hayashi
Taichi
T
Takahashi
Reiko
R
Goto
Daisuke
D
Matsumoto
Isao
I
Tsutsumi
Akito
A
Sumida
Takayuki
T
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003113:Colonoscopy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine