Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides.
The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 microg/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS), lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system.
Yuan
Huamao
H
Institute of Oceanology, Chinese Academy of Sciences, 7 Nanchi Road, Qingdao, Shandong 266071, People's Republic of China.
Song
Jinming
J
Li
Xuegang
X
Li
Ning
N
Dai
Jicui
J
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016207:Cytokines / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007111:Immunity, Cellular / Q000187:drug effects; D007155:Immunologic Factors / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009844:Oligosaccharides / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012756:Sheep; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D005641:Tegafur / Q000494:pharmacology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; D016207:Cytokines; D007155:Immunologic Factors; D009844:Oligosaccharides; D005641:Tegafur; D002351:Carrageenan