Neutralizing and hemagglutination-inhibiting activities of antibodies elicited by the 2004-2005 influenza vaccine against drifted viruses.
Evaluation of the antibody responses induced by the 2004-2005 influenza vaccine strain against the homologous variant, the 2004-2005 field isolates, and a previous circulating strain showed that a correlation between neutralizing and hemagglutination-inhibiting activities exists only when the antigen is very close to the vaccine strain.
Ansaldi
Filippo
F
Department of Health Sciences, University of Genoa, Via Pastore 1, 16100 Genoa, Italy. filippo.ansaldi@unige.it
Bacilieri
Sabrina
S
Banfi
Federica
F
Durando
Paolo
P
Sticchi
Laura
L
Icardi
Giancarlo
G
Gasparini
Roberto
R
D000914:Antibodies, Viral / Q000276:immunology*; D040961:Genetic Drift; D014644:Genetic Variation; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007252:Influenza Vaccines / Q000627:therapeutic use*; D009500:Neutralization Tests; D009975:Orthomyxoviridae / Q000145:classification* / Q000235:genetics / Q000276:immunology*; D010802:Phylogeny
D000914:Antibodies, Viral; D007252:Influenza Vaccines