Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species.
The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. The results demonstrate remarkable differences in the reactivation of inhibited brain AChE, depending on the oxime and species
Jun
Daniel
D
Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.
Kuca
Kamil
K
Cabal
Jiri
J
Bartosova
Lucie
L
Kunesova
Gabriela
G
Kassa
Jiri
J
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006801:Humans; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D012524:Sarin / Q000494:pharmacology*; D013552:Swine
D002800:Cholinesterase Inhibitors; D010091:Oximes; D012524:Sarin; D000110:Acetylcholinesterase