Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams.
Microbeam radiosurgery (MBRS), also referred to as microbeam radiation therapy (MRT), was tested at the European Synchrotron Radiation Facility (ESRF). The left tibiofibular thigh of a mouse bearing a subcutaneously (sc) implanted mouse model (SCCVII) of aggressive human squamous-cell carcinoma was irradiated in two orthogonal exposures with or without a 16 mm aluminium filter through a multislit collimator (MSC) by arrays of nearly parallel microbeams spaced 200 microm on centre (oc). The peak skin-entrance dose from each exposure was 442 Gy, 625 Gy, or 884 Gy from 35 microm wide beams or 442 Gy from 70 microm wide beams. The 442/35, 625/35, 884/35 and 442/70 MBRSs yielded 25 day, 29 day, 37 day and 35 day median survival times (MST) (post-irradiation), respectively, exceeding the 20 day MST from 35 Gy-irradiation of SCCVIIs with a seamless 100 kVp X-ray beam.
Miura
M
M
Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA.
Blattmann
H
H
Bräuer-Krisch
E
E
Bravin
A
A
Hanson
A L
AL
Nawrocky
M M
MM
Micca
P L
PL
Slatkin
D N
DN
Laissue
J A
JA
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D035002:Lower Extremity; D051379:Mice; D008809:Mice, Inbred C3H; D023421:Models, Animal; D009368:Neoplasm Transplantation; D010166:Palliative Care; D016634:Radiosurgery / Q000379:methods*; D015996:Survival Rate; D017356:Synchrotrons