title: [Management option for cervical metastases in tongue squamous cell carcinoma with clinically N0 neck].
abstract: OBJECTIVE
  This study was designed to explore the optimal management option for cervical metastases in tongue squamous cell carcinoma (SCC) with clinically N0 neck in order to avoid excessive or inadequate treatment in clinical practice.
  
  
  METHODS
  Clinical data of 327 cases of tongue SCC with cN0 neck were retrospectively analyzed. Neck control rates affected by different pathoclinical parameters were compared. Prognosis analysis and death analysis were also performed.
  
  
  RESULTS
  Overall 3-year survival was 69.7% (228/327), 3-year survival of neck recurrent group and non-recurrent group was 39.1% (25/64) and 77.2% (203/263), and 51.5% (51/99) of the death related to neck failure. Overall neck control rate was 80.4% (263/327); neck control rate of wait and watch group, level I neck dissection, level I + II neck dissection, supraomohyoid neck dissection, radical neck dissection, functional neck dissection, was 67.5% (27/40), 72.7% (24/33), 60.0% (15/25), 84.9% (45/55), 86.8% (131/151), 84.0% (21/25), respectively. Treatment modality and cervical lymph node involvement were independent factors for neck control.
  
  
  CONCLUSIONS
  Neck control is a key for prognosis of tongue SCC with cN0 neck. Supraomohyoid neck dissection is the first choice in management of cervical metastases in tongue SCC with cN0 neck, during which the suspected involved lymph nodes should be sent for frozen section to determine whether comprehensive neck dissection required. Multimodal metastasis and/or capsular spread are the indications for postoperative irradiation.
authors.affiliation: Department of Head and Neck Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Zhu-Ming
authors.initials: ZM
authors.lastname: Guo
authors.forename: Zong-Yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Fu-Jin
authors.initials: FJ
authors.lastname: Chen
authors.forename: Han-Wei
authors.initials: HW
authors.lastname: Peng
authors.forename: Mao-Wen
authors.initials: MW
authors.lastname: Wei
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: An-Kui
authors.initials: AK
authors.lastname: Yang
authors.forename: Wen-Kuan
authors.initials: WK
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000379:methods*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*