title: Serum alkaline phosphatase activity in Scottish Terriers versus dogs of other breeds.
abstract: OBJECTIVE
  To determine whether Scottish Terriers have higher serum alkaline phosphatase (ALP) activities and a higher prevalence of diseases commonly associated with high serum ALP activity than do dogs of other breeds.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  85 Scottish Terriers and 340 age-matched control dogs that were not Scottish Terriers.
  
  
  METHODS
  Medical records were reviewed, and data for year of evaluation, age, sex, breed, serum ALP activity, and final diagnosis were recorded.
  
  
  RESULTS
  Scottish Terriers had a significantly higher mean serum ALP activity than did control dogs (1,520 U/L vs 306 U/L). Regardless of breed, dogs that had a disease commonly associated with high serum ALP activity had a significantly higher mean serum ALP activity than did dogs without such diseases (1,304 U/L vs 427 U/L). Scottish Terriers were 2.4 times as likely to have a disease commonly associated with high serum ALP activity than were control dogs, but Scottish Terriers with diseases commonly associated with high serum ALP activity had a significantly higher mean ALP activity than did control dogs with such diseases (2,073 U/L vs 909 U/L), and Scottish Terriers without such diseases had a significantly higher mean serum ALP activity than did control dogs without such diseases (1,349 U/L vs 228 U/L).
  
  
  CONCLUSIONS
  Results suggest that Scottish Terriers have higher serum ALP activities than do dogs of other breeds. Although Scottish Terriers also have a higher prevalence of diseases associated with high serum ALP activity, this alone did not explain the higher mean serum ALP activity in the breed.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823, USA.
authors.forename: Derek D
authors.initials: DD
authors.lastname: Nestor
authors.forename: Kate M
authors.initials: KM
authors.lastname: Holan
authors.forename: Cheri A
authors.initials: CA
authors.lastname: Johnson
authors.forename: William
authors.initials: W
authors.lastname: Schall
authors.forename: John B
authors.initials: JB
authors.lastname: Kaneene
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000201:enzymology / Q000662:veterinary; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001947:Breeding; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000201:enzymology / Q000662:veterinary; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs / Q000097:blood* / Q000235:genetics*; D005260:Female; D008107:Liver Diseases / Q000201:enzymology / Q000662:veterinary; D008297:Male; D012189:Retrospective Studies
chemical_list: D000469:Alkaline Phosphatase