Location, movement and survival: the role of chemokines in haematopoiesis and malignancy.
Chemokines are a family of over 40 small (8 kDa) related proteins with the function of moving cells along a chemotactic gradient, either to organise cells within an organ or to facilitate the movement of leucocytes around the body. Mouse models have implicated the importance of the chemokine CXCL12 in haematopoiesis and this has lead to the use of the inhibitor AMD3100 for autologous transplantation. This review will briefly discuss the biology of chemokines and their role in haematopoiesis and haematological malignancy together with the possible benefits and hazards of therapeutic modification of the chemokine system.
Laurence
Arian D J
AD
University College Hospital London, Grafton Way, London, UK. arian.laurence@uclh.nhs.uk
D001853:Bone Marrow / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D054377:Chemokine CXCL12; D018925:Chemokines / Q000378:metabolism / Q000502:physiology*; D019743:Chemokines, CXC / Q000378:metabolism; D002633:Chemotaxis / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000503:physiopathology*; D008223:Lymphoma / Q000503:physiopathology*; D008954:Models, Biological; D019707:Receptors, Chemokine / Q000378:metabolism
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D018925:Chemokines; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D016298:Hematopoietic Cell Growth Factors; D019707:Receptors, Chemokine