Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: a 3-year follow-up study.
OBJECTIVE
To investigate the effect of H pylori eradication on atrophic gastritis and intestinal metaplasia (IM).


METHODS
Two hundred and fifty-nine patients with atrophic gastritis in the antrum were included in the study, 154 patients were selected for H pylori eradication therapy and the remaining 105 patients served as untreated group. Gastroscopy and biopsies were performed both at the beginning and at the end of a 3-year follow-up study. Gastritis was graded according to the updated Sydney system.


RESULTS
One hundred and seventy-nine patients completed the follow-up, 92 of them received H pylori eradication therapy and the remaining 87 H pylori-infected patients were in the untreated group. Chronic gastritis, active gastritis and the grade of atrophy significantly decreased in H pylori eradication group (P<0.01). However, the grade of IM increased in H pylori -infected group (P<0.05).


CONCLUSIONS
H pylori eradication may improve gastric mucosal inflammation, atrophy and prevent the progression of IM.
Lu
Bin
B
Department of Gastroenterology, Affiliated Hospital of Zhejiang Traditional Chinese Medicine College, Hangzhou 310006, Zhejiang Province China. lvbin@medmail.com.cn
Chen
Ming-Tao
MT
Fan
Yi-Hong
YH
Liu
Yan
Y
Meng
Li-Na
LN
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005757:Gastritis, Atrophic / Q000382:microbiology* / Q000473:pathology* / Q000517:prevention & control; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011230:Precancerous Conditions / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control
D000900:Anti-Bacterial Agents