title: Long-term results of abdominal salvage surgery following restorative proctocolectomy.
abstract: BACKGROUND
  This study evaluated outcomes of patients who underwent abdominal salvage ileal pouch redo surgery and identified factors associated with pouch failure following restorative proctocolectomy.
  
  
  METHODS
  Data on patients who underwent abdominal salvage surgery in a tertiary referral centre between 1985 and 2003 were collected. Outcomes studied included failure of salvage and bowel function of patients with an intact intestine.
  
  
  RESULTS
  One hundred and twelve patients underwent 117 pouch salvage procedures for ulcerative colitis (86), indeterminate colitis/ulcerative colitis (eight), indeterminate colitis/Crohn's disease (three), familial adenomatous polyposis (ten) and other conditions (five). The most common indications for pouch salvage were intra-abdominal sepsis (45 patients), anastomotic stricture (13) and retained rectal stump (35). Median follow-up was 46 (range 1-147) months. Twenty-four patients (21.4 per cent) experienced pouch failure, the incidence of which increased with time. The pouch failed in all patients with Crohn's disease. Successful salvage at 5 years was significantly associated with non-septic (85 per cent) rather than septic (61 per cent) indications (P = 0.016). Frequency of night-time defaecation and faecal urgency improved after salvage surgery (P = 0.036 and P = 0.016 respectively at 5-year follow-up; n = 32).
  
  
  CONCLUSIONS
  Abdominal salvage surgery was associated with a failure rate of 21.4 per cent. A successful outcome was less likely when the procedure was carried out for septic compared with non-septic indications. The rate of pouch failure increased with length of follow-up.
authors.affiliation: Department of Surgery, St Mark's Hospital, Watford Road, Harrow HA1 3UJ, UK.
authors.forename: P P
authors.initials: PP
authors.lastname: Tekkis
authors.forename: A G
authors.initials: AG
authors.lastname: Heriot
authors.forename: J J
authors.initials: JJ
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: Das
authors.forename: A
authors.initials: A
authors.lastname: Canero
authors.forename: R J
authors.initials: RJ
authors.lastname: Nicholls
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003108:Colonic Diseases / Q000601:surgery*; D039021:Colonic Pouches; D005260:Female; D006085:Graft Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative; D016879:Salvage Therapy; D016019:Survival Analysis; D017211:Treatment Failure