title: From total empiricism to a rational design of metronomic chemotherapy phase I dosing trials.
abstract: 'Metronomic chemotherapy' represents a novel anti-angiogenic strategy whereby low-dose chemotherapy is utilized in a continuous fashion in order to target tumor endothelium. There are many potential advantages of this strategy and clinical trials are already underway. However, although the scheduling of metronomic chemotherapy is relatively unequivocal, metronomic dosing principles are at present poorly defined. Arbitrarily, 10-33% of the maximum tolerated dose comprises 'the dose range'. We argue that this is too empirical and propose a set of phase I metronomic chemotherapy dosing strategies based on a principled approach which may help to reduce the problem of empiricism in dosing for metronomic chemotherapy trials.
authors.affiliation: Postgraduate Medical Institute, University of Hull, Hull, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lam
authors.forename: John W
authors.initials: JW
authors.lastname: Hetherington
authors.forename: John
authors.initials: J
authors.lastname: Greenman
authors.forename: Anthony
authors.initials: A
authors.lastname: Maraveyas
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000818:Animals; D017321:Clinical Trials, Phase I as Topic; D019348:Empiricism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors