title: [Influence of anthropogenic pollution on thyroid structure in Perm population].
abstract: The comparison of the thyroid structure in 73 Perm sitizens who died in the 1960s with that of 59 citizens who died in the 2000s revealed in the latter group symptoms of "tissue maladaptation" (retention of follicular colloid with cystic transformation of the follicles, lymphoplasma cell infiltration with oxyfilic thyrocytes transformation into B-cells, appearance of areas with a rough connective tissue in colloidrhagia and edema with capillary collapse, calcium deposits into the vessels and stroma). It is proven that these morphological changes are due to the effects of xenobiotics. Pronounced increase of heavy metals deposits in the thyroid by the 2000s was reported. Such thyroid pathomorphosis inevitably results in hypothyroidism.
authors.forename: V I
authors.initials: VI
authors.lastname: Bronnikov
authors.forename: T P
authors.initials: TP
authors.lastname: Goldyreva
authors.forename: I V
authors.initials: IV
authors.lastname: Tereshchenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000009:adverse effects* / Q000378:metabolism; D008875:Middle Aged; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology*
chemical_list: D019216:Metals, Heavy