Multifunctionality of human 17beta-hydroxysteroid dehydrogenases.
17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) belong to the family of short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs). Some of the enzymes were discovered and named due to their enzymatic activity on steroid substrates or according to their sequence homology to other 17beta-HSDs. During characterisation of these enzymes it turned out that their substrate specificity is broader than first expected and key functions of some 17beta-HSDs in vivo are probably not in steroid metabolism but in basic metabolic pathways. The issue of such multifunctionality is the topic of this review.
Moeller
Gabriele
G
GSF-National Research Center of Environment and Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany. gabriele.moeller@gsf.de
Adamski
Jerzy
J
D015067:17-Hydroxysteroid Dehydrogenases / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D011487:Protein Conformation; D013256:Steroids / Q000378:metabolism*; D013379:Substrate Specificity
D013256:Steroids; D015067:17-Hydroxysteroid Dehydrogenases