title: [Molecular mechanism of bone absorption in osteoclast].
abstract: The physiological reconstruction of bone is strictly dependent on bone resorption. Bone resorption is believed to be a complicated molecular reaction process that occurs in the microcircumstance of bone tissue. A lot of enzymes and factors take part in this process, yet there are not enough data with reference to the activation of osteoclast, resorption of bone matrix, regulation of bone resorption. In this paper we review the importance of matrix metalloproteinases (MMPs) in transfer of osteoclast and degradation of bone matrix, and the function of receptor activator of NF-kappaB-ligand (RANKL) and osteoprotegerin (OPG) in regulation of bone resorption.
authors.affiliation: Key Laboratory of Biomechanics & Tissue Engineering , Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Pan
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Deng
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Yuanliang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001862:Bone Resorption; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D010010:Osteoclasts / Q000502:physiology*; D053244:Osteoprotegerin / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology*
chemical_list: D053244:Osteoprotegerin; D053245:RANK Ligand; C505688:TNFSF11 protein, human; D020782:Matrix Metalloproteinases