title: Gastric cancer: standards for the 21st century.
abstract: Although the incidence of gastric cancer has been decreasing in the United States, it remains a leading cause of cancer death in the world, only lung cancer causes more deaths worldwide. The combination of relatively low prevalence, lack of pathognomonic symptoms, and lack of defined risk factors are associated with a delay in diagnosis leading to a dismal prognosis. For localized disease, surgery remains a cornerstone of treatment but much controversy remains regarding optimal peri-operative therapy. For advanced disease, several new agents and new combination chemotherapies have offered encouraging results. This paper seeks to review the major topics surrounding gastric cancer and cover the results of recently reported and ongoing trials.
authors.affiliation: Department of Radiation Oncology, The David Geffen U.C.L.A. School of Medicine, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Archie
authors.forename: John
authors.initials: J
authors.lastname: Kauh
authors.forename: Dennie V
authors.initials: DV
authors.lastname: Jones
authors.forename: Victor
authors.initials: V
authors.lastname: Cruz
authors.forename: Martin S
authors.initials: MS
authors.lastname: Karpeh
authors.forename: Charles R
authors.initials: CR
authors.lastname: Thomas
mesh_terms: D017024:Chemotherapy, Adjuvant / Q000592:standards; D003131:Combined Modality Therapy / Q000592:standards; D006801:Humans; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000628:therapy