title: Reversible hypocalcemic heart failure with T wave alternans and increased QTc dispersion in a patient with chronic renal failure after parathyroidectomy.
abstract: Despite the crucial role of calcium in myocardial contractility, hypocalcemia has very rarely been reported as a reversible cause of heart failure. In this article, we describe a case of a 51-year-old woman with advanced stages of chronic renal failure after parathyroidectomy who exhibited congestive heart failure, severe hypocalcemia, hypomagnesemia and hypokalemia. Severe hypocalcemia resulted from discontinuation of taking calcium supplements after parathyroidectomy and from reduced 1.25(OH)2D3 synthesis by damaged kidneys. The patient presented with reduced left ventricular ejection fraction (EF) and ECG abnormalities (T wave alternans and increased QTc dispersion), both of which improved after correction of serum calcium levels. Her serum levels of total calcium corrected for serum albumin, but not serum levels of magnesium or potassium, positively and negatively correlated with EF and QTc dispersion, respectively. In the present case, both heart failure and the ECG abnormalities are directly associated with hypocalcemia.
authors.affiliation: Department of Nephrology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwazu
authors.forename: S
authors.initials: S
authors.lastname: Muto
authors.forename: S
authors.initials: S
authors.lastname: Ikeuchi
authors.forename: S
authors.initials: S
authors.lastname: Yanagiba
authors.forename: Y
authors.initials: Y
authors.lastname: Miyata
authors.forename: Y
authors.initials: Y
authors.lastname: Asano
authors.forename: E
authors.initials: E
authors.lastname: Kusano
mesh_terms: D002118:Calcium / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D006996:Hypocalcemia / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D007008:Hypokalemia / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications*; D008274:Magnesium / Q000097:blood; D008875:Middle Aged; D016105:Parathyroidectomy; D011183:Postoperative Complications; D011188:Potassium / Q000097:blood; D013318:Stroke Volume
chemical_list: D008274:Magnesium; D011188:Potassium; D002118:Calcium