title: Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS.
abstract: The authors calculated the progression rate (DeltaFS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the DeltaFS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the DeltaFS provides an additional predictive index beyond ALSFRS-R alone.
authors.affiliation: Division of Neurology, First Department of Internal Medicine, Osaka Medical College, Osaka, Japan. in1110@poh.osaka-med.ac.jp
authors.forename: F
authors.initials: F
authors.lastname: Kimura
authors.forename: C
authors.initials: C
authors.lastname: Fujimura
authors.forename: S
authors.initials: S
authors.lastname: Ishida
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: D
authors.initials: D
authors.lastname: Furutama
authors.forename: H
authors.initials: H
authors.lastname: Uehara
authors.forename: K
authors.initials: K
authors.lastname: Shinoda
authors.forename: M
authors.initials: M
authors.lastname: Sugino
authors.forename: T
authors.initials: T
authors.lastname: Hanafusa
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000401:mortality* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008136:Longevity; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012720:Severity of Illness Index