title: The outcome of surgery in fulminant Clostridium difficile colitis.
abstract: BACKGROUND
  The clinical presentation of Clostridium difficile infection ranges from asymptomatic carriage, colitis with or without pseudomembranes, to fulminant colitis. Although not common, fulminant C. difficile colitis can result in bowel perforation and peritonitis with a high mortality rate. Colectomy is often indicated in these cases.
  
  
  METHODS
  We retrospectively analysed the outcome of 14 patients who underwent surgery for fulminant C. difficile colitis in the period 1996-2003 in our Unit.
  
  
  RESULTS
  The indications for surgery were systemic toxicity and peritonitis (n = 10), radiological and clinical evidence of progressive toxic colonic dilatation (n = 3) and progressive colonic dilatation with bowel perforation (n = 1). C. difficile infection as the cause of colitis was diagnosed pre-operatively in seven (50%) patients, six of whom underwent a total colectomy and one a right hemicolectomy. Overall mortality in our series was 35.7%. Total colectomy was associated with a lower mortality rate of 11.1% (1/9) when compared with left hemicolectomy was 100% (4/4) (P = 0.01). One patient who underwent a right hemicolectomy (on the basis of deceptively normal external appearance of the rest of the colon intra-operatively) survived after a prolonged hospital stay.
  
  
  CONCLUSIONS
  Early or pre-operative microbiological diagnosis of C. difficile infection can be difficult in patients with a fulminant presentation. Those patients with C. difficile colitis, who develop signs of toxicity, peritonitis or perforation, should undergo a total colectomy as the operation of choice.
authors.affiliation: Gastrointestinal Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK.
authors.forename: K
authors.initials: K
authors.lastname: Koss
authors.forename: M A
authors.initials: MA
authors.lastname: Clark
authors.forename: D S A
authors.initials: DS
authors.lastname: Sanders
authors.forename: D
authors.initials: D
authors.lastname: Morton
authors.forename: M R B
authors.initials: MR
authors.lastname: Keighley
authors.forename: J
authors.initials: J
authors.lastname: Goh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016360:Clostridioides difficile; D003082:Colectomy; D004761:Enterocolitis, Pseudomembranous / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome