Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives.
Novel 1,3,9-triazacyclopenta[b]fluorene-4,10-diones and 1,3,9-triazacyclopenta[b]fluorene, analogue of ellipticine, were synthesised, and evaluated in vitro for their antiproliferative activity on various breast cancer cell lines.
Desforges
Gwenaelle
G
Laboratoire de Chimie Organique 1, UMR-CNRS 5181, Université Claude Bernard, Lyon 1, CPE, Bâtiment 308, 43 Boulevard du 11 Novembre 1918 69622, Villeurbanne cedex, France.
Picot
Laurent
L
Montagne
Cyril
C
Thiéry
Valérie
V
Besson
Thierry
T
Joseph
Benoit
B
D001943:Breast Neoplasms / Q000188:drug therapy*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D002227:Carbazoles; D005449:Fluorenes; D007093:Imidazoles