title: Surgical treatment of primary locally advanced rectal cancer in Norway.
abstract: OBJECTIVE
  Most reports on locally advanced rectal cancer come from specialized centres, with a selected patient material. The purpose of this study was to examine the results after surgical treatment of patients with locally advanced rectal cancer at a population level.
  
  
  METHODS
  National cohort study of 896 patients undergoing surgery for a locally advanced primary adenocarcinoma of the rectum from November 1993 to December 2001.
  
  
  RESULTS
  Surgery with resection was undertaken in 724 patients and 172 patients underwent palliative procedures. Of 557 patients treated for cure, a R0 resection was achieved in 342 (61%). In a multivariate analysis, pre-operative radiotherapy was the only factor with a positive association with R0 status (odds ratio 3.7, 95% confidence interval (CI) 2.1-6.4). Five-year local recurrence rates were 18% (CI 14-23) for R0 resections and 40% (CI 26-52) for R1 resections. Overall 5-year survival rate was 23%; for the group of patients with a R0 resection the survival rate was 49%.
  
  
  CONCLUSIONS
  The radical resection rate and survival rates in this national study were similar to those reported from specialized centres.
authors.affiliation: Department of Surgery, Buskerud Hospital, 3004 Drammen, Norway. mteriksen@start.no
authors.forename: M T
authors.initials: MT
authors.lastname: Eriksen
authors.forename: A
authors.initials: A
authors.lastname: Wibe
authors.forename: U E
authors.initials: UE
authors.lastname: Hestvik
authors.forename: J
authors.initials: J
authors.lastname: Haffner
authors.forename: J N
authors.initials: JN
authors.lastname: Wiig
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D013505:Digestive System Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009664:Norway / Q000453:epidemiology; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012737:Sex Factors; D015996:Survival Rate; D016896:Treatment Outcome