[Regression of hepatic fibrosis].
Extensive and persistent hepatic fibrosis has for a long time been considered irreversible. However, recent studies on the behavior of hepatic fibrosis, especially those related to evolution and involution of advanced schistosomiasis in man, have challenged this concept, and nowadays it is becoming clear that any type of fibrosis is reversible, including that associated with hepatic cirrhosis. The problem consists in identifying and eliminating its cause. Although fibrosis in the liver has little functional significance by itself, its severity derives from associated vascular changes. However, new data on fibrosis regression indicate that disappearance of fibrosis is usually accompanied by remodeling of vascular changes. But, there are peculiarities related to the anatomic type of fibrosis and to its functional significance, which suggest that sometimes fibrosis may indeed be irreversible. These aspects, some of which in need of further studies, are presented and discussed herein.
Andrade
Zilton A
ZA
Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA. zilton@cpqgm.fiocruz.br
D000818:Animals; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000469:parasitology / Q000503:physiopathology*; D008106:Liver Cirrhosis, Experimental / Q000469:parasitology / Q000503:physiopathology; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000503:physiopathology*; D012074:Remission Induction; D012552:Schistosomiasis / Q000150:complications*; D012720:Severity of Illness Index; D013997:Time Factors