title: Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization-embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures.
abstract: We performed a double-blinded retrospective cohort study to determine whether endometrial expression of mouse ascites Golgi mucin in a natural, unmedicated cycle predicts subsequent IVF-ET outcome among women with prior IVF-ET failure and poor pre-embryo quality. We found a statistically significant decrease in clinical pregnancy rate among women with abnormal mouse ascites Golgi expression, a test which was found to have high positive predictive value for failed IVF-ET.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, Connecticut, USA.
authors.forename: Jillian S
authors.initials: JS
authors.lastname: Catalanotti
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Spandorfer
authors.forename: Larry I
authors.initials: LI
authors.lastname: Barmat
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
authors.forename: Juliette C
authors.initials: JC
authors.lastname: McSweet
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Kliman
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology / Q000378:metabolism*; D000328:Adult; D000906:Antibodies; D015415:Biomarkers; D001706:Biopsy; D015331:Cohort Studies; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D000939:Epitopes / Q000276:immunology / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009077:Mucins / Q000276:immunology / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D000017:ABO Blood-Group System; D000906:Antibodies; D015415:Biomarkers; D000939:Epitopes; D009077:Mucins