title: The use of antidepressants to treat depression in children and adolescents.
abstract: The dramatic increase over the past 10 years in the amount of available clinical research on the use of antidepressants to treat major depression in children and adolescents has substantially improved our knowledge of the safety and efficacy of these medications in the pediatric population. Many questions remain, however, that highlight the need to continue research in this patient population rather than relying on the extrapolation of data from trials involving adults. In this article, we review the current state of research into antidepressant therapy for major depression in children and adolescents. In addition, we discuss methodologic issues and clinical implications specific to the pediatric population.
authors.affiliation: Department of Psychiatry, University of Toronto, Toronto, Ont. amy_cheung@camh.net
authors.forename: Amy H
authors.initials: AH
authors.lastname: Cheung
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Emslie
authors.forename: Taryn L
authors.initials: TL
authors.lastname: Mayes
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D003865:Major Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D013405:Suicide / Q000523:psychology
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors