Fabrication of photo-encoded beads for bioanalysis.
Encoding large libraries of biomolecules is important to the applications such as immunoassay, drug screening and so on. By now a number of encoding schemes have been proposed and developed. In this paper, a new encoding approach was proposed based on the photonic crystal beads and an apparatus was developed for the fabrication. Encoded beads, with diameters in the range between 0.2 mm and 3 mm, were prepared using polymer and pearl dye. Pearl dye is a kind of photonic crystal, the color of which is from the ordered nanostructure. Such a colorizing mechanism makes the color of pearl dye much stable to high temperature, UV irradiation or longtime storage comparing with the conventional dyes.
Yang
Han
H
State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, P. R. China.
Nagai
Keiji
K
Zhao
Xiangwei
X
Chen
Haihua
H
Gul
Zhong-Ze
ZZ
D003116:Color; D004396:Coloring Agents / Q000737:chemistry; D003460:Crystallization; D007118:Immunoassay; D008027:Light; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D008863:Microspheres; D015335:Molecular Probes; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D017785:Photons; D011108:Polymers / Q000737:chemistry; D013696:Temperature; D014466:Ultraviolet Rays
D004396:Coloring Agents; D015335:Molecular Probes; D011108:Polymers