title: Increased circulating concentrations of growth-related oncogene (GRO)-alpha in patients with inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory state associated with increased risk of intestinal cancers. The aim of this study is to examine serum concentrations of growth-related oncogene (GRO)-alpha, a cytokine with inflammatory and growth-regulatory properties, in patients with IBD. We measured serum concentrations of GRO-alpha in 60 patients with ulcerative colitis, 42 patients with Crohn's disease, 16 patients with other colitides, 12 patients with colorectal cancer, and 40 normal subjects using an enzyme-linked immunosorbent assay. We then analyzed how the cytokine was related to clinical and laboratory variables. Serum GRO-alpha concentrations in patients with active IBD were significantly higher than those in patients with quiescent disease, which in turn were higher than those in normal controls. Concentrations in patients with active ulcerative colitis were higher than in patients with active Crohn's disease. Analysis of paired serum samples showed a decrease in GRO-alpha after initiation of therapy. Furthermore, serum GRO-alpha correlated well with laboratory markers of IBD activity. We conclude that GRO-alpha may have an important role in development of IBD, and might itself be used as a marker of activity. Manipulation of GRO-alpha function might prove therapeutically useful.
authors.affiliation: Second Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, Japan. ibd@med.kurume-u.ac.jp
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mitsuyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Tsuruta
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tomiyasu
authors.forename: Kosuke
authors.initials: K
authors.lastname: Takaki
authors.forename: Asuka
authors.initials: A
authors.lastname: Suzuki
authors.forename: Junya
authors.initials: J
authors.lastname: Masuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Toyonaga
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D054360:Chemokine CXCL1; D019743:Chemokines, CXC / Q000097:blood*; D003093:Colitis, Ulcerative / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood; D003424:Crohn Disease / Q000097:blood*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D036341:Intercellular Signaling Peptides and Proteins