title: Low-prime system minimizes transfusions and hemodilution in coronary bypass.
abstract: Standard heart-lung machines lead to substantial hemodilution with associated impaired organ function and increased need for blood transfusions. The aim of this study was to evaluate the effect of the new PRECiSe low prime volume system on perioperative myocardial damage, hemodilution, and transfusions. In a case-matched prospective study, 40 patients undergoing coronary artery bypass surgery using PRECiSe were compared with 40 patients on a standard heart-lung machine. In the PRECiSe group, the prime volume was significantly reduced, resulting in less hemodilution and transfusion requirements during and after extracorporeal circulation: only 10% of patients needed transfusions vs. 35% in the control group, with an average transfusion need of 0.16 vs. 1.25 units. There were no significant differences in perioperative cardiac-specific enzymes. The PRECiSe system was considered safe and effective for coronary artery bypass surgery.
authors.affiliation: Department of Cardiovascular Surgery, Charité-University Medicine Berlin, Berlin, Germany. sven.beholz@charite.de
authors.forename: Sven
authors.initials: S
authors.lastname: Beholz
authors.forename: Liling
authors.initials: L
authors.lastname: Zheng
authors.forename: Martin
authors.initials: M
authors.lastname: Rusche
authors.forename: Michael
authors.initials: M
authors.lastname: Kessler
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Konertz
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation* / Q000379:methods*; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006355:Heart-Lung Machine / Q000009:adverse effects / Q000592:standards*; D006438:Hemodilution / Q000706:statistics & numerical data*; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D016896:Treatment Outcome