Recurrent herpes labialis during isotretinoin therapy: is there a role for photosensitivity?
Isotretinoin (13-cis-retinoic acid) is one of the synthetic retinoids derived from vitamin A. Vitamin A derivatives demonstrate virucidal activity, both in vivo and in vitro. Isotretinoin has been used for the treatment of recurrent herpes simplex with encouraging results. However, we present a case with frequent attacks of herpes labialis during isotretinoin therapy for acne, who had a marked decrease in frequency of recurrences following strict use of sunscreens.
Yazici
A C
AC
Department of Dermatology, Faculty of Medicine, Mersin University, Mersin, Turkey. aycacordan@yahoo.com
Baz
K
K
Ikizoglu
G
G
D000152:Acne Vulgaris / Q000188:drug therapy*; D000328:Adult; D005260:Female; D006560:Herpes Labialis / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D012008:Recurrence; D013473:Sunscreening Agents / Q000627:therapeutic use
D013473:Sunscreening Agents; D015474:Isotretinoin