title: Alcohol metabolism of local Chinese in Hong Kong: a statistical determination on the effects of various physiological factors.
abstract: A study was designed to examine the elimination rate of alcohol from the body of the local Chinese after consumption of different types of alcoholic drinks. The breath alcohol of 184 healthy volunteers was determined and converted into blood alcohol levels after they finished drinking. Information on the type and volume of alcoholic drinks consumed, age group, sex, drinking habit, and drinking on empty stomach or with/after meal was recorded for each participant. The results show that the elimination rate of an individual can be explained in terms of physiological variables including sex and drinking habit. The determined elimination rates allow forensic toxicologists to back calculate the blood alcohol concentration (BAC) of the drivers at the time of accident in drunk driving cases. The elimination rates of blood alcohol at 95% prediction intervals for male and female are in the range of 9.5-23.8 mg/100 ml/h and 11.1-37.1 mg/100 ml/h, respectively.
authors.affiliation: Forensic Toxicology Section, Government Laboratory, 88 Chung Hau Street, Ho Man Tin, Kowloon, Hong Kong, China. wmtam@govtlab.gov.hk
authors.forename: Thomas W M
authors.initials: TW
authors.lastname: Tam
authors.forename: C T
authors.initials: CT
authors.lastname: Yang
authors.forename: W K
authors.initials: WK
authors.lastname: Fung
authors.forename: Vincent K K
authors.initials: VK
authors.lastname: Mok
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D000704:Analysis of Variance; D001944:Breath Tests; D002492:Central Nervous System Depressants / Q000097:blood / Q000493:pharmacokinetics*; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D005215:Fasting; D005260:Female; D006723:Hong Kong; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol