title: Silent cerebral white matter lesions and their relationship with vascular risk factors in middle-aged predialysis patients with CKD.
abstract: BACKGROUND
  Silent cerebral white matter lesions are observed on magnetic resonance imaging (MRI) scans in elderly people, and they are related to vascular risk factors, particularly hypertension. No data on the prevalence and risk factors of white matter lesions in patients with chronic kidney disease (CKD) are available. The aim is to analyze the prevalence of white matter lesions and their determinants in this population.
  
  
  METHODS
  We studied 52 patients without diabetes with CKD (stage 3 or 4) aged 30 to 60 years (average, 49 years) and a group of 32 normotensive control subjects. MRI studies were performed and subcortical and periventricular white matter lesions were evaluated by using semiquantitative measures. Patients were classified into 2 groups depending on the presence or absence of white matter lesions. Echocardiographic studies and measures of markers of systemic inflammation (C-reactive protein and interleukin 6) also were performed.
  
  
  RESULTS
  White matter lesions were more prevalent in patients with CKD than controls (33% versus 6%; P = 0.008). Patients with CKD who had white matter lesions were older; had a greater history of cardiovascular disease and vascular nephropathy as a primary cause of renal disease and greater levels of systolic blood pressure, pulse pressure, left ventricular mass index, and C-reactive protein; and were administered more antihypertensive drugs than patients with CKD without white matter lesions. Stage and duration of CKD were not related to the presence of white matter lesions. After adjusting for several factors, only vascular nephropathy (odds ratio, 15.6; 95% confidence interval, 1.27 to 191.54; P = 0.03) independently predicted an increased risk for white matter lesions.
  
  
  CONCLUSIONS
  One third of middle-aged patients with CKD have silent cerebral white matter lesions. Vascular nephropathy seems to be the most important factor related to the presence of these lesions, suggesting that white matter lesions reflect ischemic brain damage caused by generalized vascular damage.
authors.affiliation: Nephrology Service, Institut de Diagnostic per la Imatge, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain. amtz@hjxxiii.scs.es
authors.forename: Alberto
authors.initials: A
authors.lastname: Martinez-Vea
authors.forename: Esther
authors.initials: E
authors.lastname: Salvadó
authors.forename: Alfredo
authors.initials: A
authors.lastname: Bardají
authors.forename: Cristina
authors.initials: C
authors.lastname: Gutierrez
authors.forename: Ana
authors.initials: A
authors.lastname: Ramos
authors.forename: Carmen
authors.initials: C
authors.lastname: García
authors.forename: Teresa
authors.initials: T
authors.lastname: Compte
authors.forename: Carmen
authors.initials: C
authors.lastname: Peralta
authors.forename: Montse
authors.initials: M
authors.lastname: Broch
authors.forename: Rosa
authors.initials: R
authors.lastname: Pastor
authors.forename: Pere
authors.initials: P
authors.lastname: Angelet
authors.forename: Luis
authors.initials: L
authors.lastname: Marcas
authors.forename: Amadeo
authors.initials: A
authors.lastname: Saurí
authors.forename: Jesús Angel
authors.initials: JA
authors.lastname: Oliver
mesh_terms: D000328:Adult; D000367:Age Factors; D001927:Brain Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors