Association of the circulating adiponectin concentration with coronary in-stent restenosis in haemodialysis patients.
BACKGROUND
Success of coronary stenting is limited by in-stent restenosis. We aimed to determine whether circulating levels of the cytokines, which have anti-inflammatory properties such as adiponectin or interleukin-10, could be associated with the occurrence of coronary in-stent restenosis in patients with end-stage renal disease (ESRD).


METHODS
We enrolled 71 consecutive ESRD patients undergoing haemodialysis (mean age: 64.9+/-8.9 years; 19 women, 52 men; mean haemodialysis duration: 78.2+/-87.5 months), who received stenting for a single coronary lesion. Plasma concentrations of adiponectin and IL-10 were measured within one week before coronary stenting.


RESULTS
Of the 71 patients who had received stenting, in-stent restenosis occurred in 37 patients (52.1%) within 6 months after stenting. In univariate logistic analysis, the homeostasis model assessment index of insulin resistance, blood haemoglobin, serum concentrations of high density lipoprotein-cholesterol or triglycerides and plasma concentrations of insulin or adiponectin were significantly associated with coronary in-stent restenosis. In a multiple logistic regression analysis among these variables, however, only the plasma adiponectin concentration was associated with the coronary in-stent restenosis: the odds ratio of the increase in 1 microg/ml of plasma adiponectin concentration for having restenosis was 0.651 (P = 0.001, 95% confidence interval: 0.506-0.839). Patients with restenosis had lower plasma adiponectin concentrations than those without [6.2+/-2.2 microg/ml (2.1-10.4 microg/ml; n = 37) vs 27.2+/-10.8 microg/ml (17.9-79.8 microg/ml; n = 34); P = 0.0001].


CONCLUSIONS
Circulating adiponectin concentrations may be associated with the occurrence of coronary in-stent restenosis in ESRD patients undergoing maintenance haemodialysis.
Nishimura
Masato
M
Cardiovascular Division, Toujinkai Hospital, 83-1, Iga, Kyoto 612-8026, Japan. mnishimura@tea.ocn.ne.jp
Hashimoto
Tetsuya
T
Kobayashi
Hiroyuki
H
Yamazaki
Satoru
S
Okino
Koji
K
Fujita
Hiroshi
H
Inoue
Naoto
N
Takahashi
Hakuo
H
Ono
Toshihiko
T
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D023903:Coronary Restenosis / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D006435:Renal Dialysis; D015607:Stents / Q000009:adverse effects*
D052242:Adiponectin