title: Olfactory neuroblastoma causing ectopic ACTH syndrome.
abstract: A 39-year-old woman who presented with typical Cushingoid appearance (moon facies, central obesity, purpura) was admitted to our hospital because of pulmonary infection. She was found to have hypertension, severe hypokalemia, and metabolic alkalosis. Endocrine data revealed elevated plasma levels of ACTH and cortisol with lack of circadian rhythm, non-suppressibility to high-dose dexamethasone, and hyperresponsiveness to CRH stimulation. Although no pituitary mass was detected by MRI of the brain, inferior petrosal sinus sampling showed a step-up of central to peripheral ACTH levels; these data are consistent with the diagnosis of Cushing's disease. She was successfully treated with metyrapone to control hypercortisolemia. Ten months later, a mass was detected in the ethmoid sinus, which was surgically removed. After resection of the ethmoid sinus tumor, her Cushingoid features and hypercortisolemia disappeared, but recurred after enlargement of a second mass in the maxillary sinus. After resection of the maxillary sinus tumor, her hypercortisolemia subsided. Histologically, the tumor tissues from both the ethmoid and maxillary sinus were identical and consistent with the diagnosis of olfactory neuroblastoma. Immunohistochemically, the immunoreactivities of ACTH and POMC were positive in the cytoplasm of tumor cells, and immunoreactive ACTH was demonstrated in both tumor tissues. Thus, this is the second rare case with ectopic ACTH syndrome caused by olfactory neuroblastoma thus far reported.
authors.affiliation: Division of Endocrinology and Metabolism, Musashino Red Cross Hospital, Tokyo.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kanno
authors.forename: Yuki
authors.initials: Y
authors.lastname: Morokuma
authors.forename: Toru
authors.initials: T
authors.lastname: Tateno
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirono
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Taki
authors.forename: R Yoshiyuki
authors.initials: RY
authors.lastname: Osamura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hirata
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000097:blood; D000328:Adult; D002940:Circadian Rhythm; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D018304:Esthesioneuroblastoma, Olfactory / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007150:Immunohistochemistry; D009669:Nose Neoplasms / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis; D010255:Paranasal Sinus Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D011333:Pro-Opiomelanocortin / Q000032:analysis
chemical_list: D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone