Neuronal activity related to elapsed time in prefrontal cortex.
We studied prefrontal cortex activity during a saccade task. On each trial, one of three delay periods elapsed between the onset of a visual stimulus and its offset, which triggered a saccade. After stimulus offset, many neurons showed phasic increases in activity that depended on the duration of the preceding delay period. This delay-dependent activity varied only weakly with reaction time and instead appeared to reflect a more general aspect of elapsed time.
Genovesio
Aldo
A
Laboratory of Systems Neuroscience, National Institute of Mental Health, Building 49, Room B1EE17, 49 Convent Drive, MSC 4401, Bethesda, MD 20892-4401, USA.
Tsujimoto
Satoshi
S
Wise
Steven P
SP
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D008253:Macaca mulatta; D009474:Neurons / Q000145:classification / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000166:cytology*; D011597:Psychomotor Performance; D011930:Reaction Time / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D013997:Time Factors