title: Oral magnesium administration prevents thermal hyperalgesia induced by diabetes in rats.
abstract: BACKGROUND
  Peripheral neuropathy is a common complication of diabetes mellitus. It has been shown that hyperglycemia may contribute to its development but the exact pathophysiology underlying this complication is not fully understood. Since oral magnesium supplementation can normalize hyperglycemia induced by diabetes in rats, this study was designed to examine the effect of oral magnesium administration on thermal hyperalgesia in streptozocin-induced diabetic rats.
  
  
  METHODS
  Twenty-four male adult wistar rats were divided equally into control, magnesium-treated control, diabetic and magnesium-treated diabetic groups. In magnesium-treated diabetic rats, magnesium sulfate (10g/l) was added into the drinking water once diabetes was established (10 days after STZ injection) and continued for 8 weeks. Mg-treated control animals received magnesium sulfate in the same dose and over the same time period. The other two groups; control and diabetic animals, only received tap water. At the end of the 8 weeks, thermal pain threshold was assessed by tail flick test and magnesium and glucose plasma levels were measured in all groups.
  
  
  RESULTS
  A significant decrease (p<0.001) in thermal pain threshold and plasma magnesium levels and an increase in plasma glucose levels (p<0.001) were seen in diabetic rats 8 weeks after diabetes induction. After 8 weeks of oral magnesium, thermal hyperalgesia was normalized and plasma magnesium and glucose levels were restored towards normal.
  
  
  CONCLUSIONS
  It is concluded that oral magnesium administration given at the time of diabetes induction may be able to restore thermal hyperalgesia, magnesium deficiency and hyperglycemia and in diabetic rats.
authors.affiliation: Department of Biology, Bu-Ali Sina University, Hamadan, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Hasanein
authors.forename: Mohsen
authors.initials: M
authors.lastname: Parviz
authors.forename: Mansoor
authors.initials: M
authors.lastname: Keshavarz
authors.forename: Kazem
authors.initials: K
authors.lastname: Javanmardi
authors.forename: Marzieh
authors.initials: M
authors.lastname: Mansoori
authors.forename: Nepton
authors.initials: N
authors.lastname: Soltani
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D003929:Diabetic Neuropathies / Q000517:prevention & control; D006358:Hot Temperature / Q000009:adverse effects; D006930:Hyperalgesia / Q000517:prevention & control*; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D008278:Magnesium Sulfate; D008274:Magnesium