[Synthesis and antitumour activity of metal complexes of bacteriochlorophyll].
OBJECTIVE
To find a new PDT sensitizer.


METHODS
There were four complexes (Cu, Zn, Co, Ni) synthesized through reaction of metal and deprivating-Mg bacteriochlorophyll in the organic solvent. Their antitumor action was detected by MTT.


RESULTS
The ultraviolet-visual spectrum and the fluorescence spectrum of these complexes showed that synthesis of these four complexes was succeeded. And these metal complexes have potent antitumor action on two kinds of leukaemic cells.


CONCLUSIONS
Metal bacteriochlorophylls as PDT sensitizers have very good properties and this is a way to develop new PDT sensitizers.
Wang
Meng-Liang
ML
Institute of Modern Chemistry, Shanxi University, Taiyuan 030006, China. mlwang@sxu.edu.cn
Chang
Ru-Bo
RB
Liu
Dian-Sheng
DS
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001429:Bacteriochlorophylls / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D018922:HL-60 Cells / Q000166:cytology; D006801:Humans; D020014:K562 Cells / Q000166:cytology; D019216:Metals, Heavy / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry
D000970:Antineoplastic Agents; D001429:Bacteriochlorophylls; D019216:Metals, Heavy; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc