title: Dibutyl phthalate, the bioactive compound produced by Streptomyces albidoflavus 321.2.
abstract: It was found that the bioactive compound, dibutyl phthalate, was produced by a new soil isolate Streptomyces albidoflavus 321.2. Once this active compound was recovered by ethyl acetate from the fermented broth, being possible to isolate 13.4 mg/l, it was purified by paper, silica gel column, thin layer and gas chromatography. Structure was determined by analysing UV, IR and GC-MS spectra. During analysis, such active compound showed strong activity against gram-positive and gram-negative bacteria, as well as unicellular and filamentous fungi. The antimicrobial activity of the compound was reversed by the amino acid proline. No acute toxicity was observed.
authors.affiliation: Department of Botany, School of Life Sciences, Visva-Bharati, Santiniketan-731235, India.
authors.forename: R N
authors.initials: RN
authors.lastname: Roy
authors.forename: S
authors.initials: S
authors.lastname: Laskar
authors.forename: S K
authors.initials: SK
authors.lastname: Sen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D002845:Chromatography / Q000379:methods; D003993:Dibutyl Phthalate / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D003993:Dibutyl Phthalate