Functional maturation of adult-generated granule cells.
The excitability and connectivity of adult-generated granule cells dictate to what extent newborn neurons participate in the hippocampal network. These functional parameters evolve as newborn cells mature and interact with the existing circuit. The progression of granule cell maturation during neonatal development appears to be reiterated in the adult, but with some caveats. New approaches to identify and track newborn neurons are revealing the timing of this process, as well as its sensitivity to activity-dependent regulation.
Overstreet-Wadiche
Linda S
LS
Vollum Institute, L474, Oregon Health & Science University, Portland, Oregon 97239, USA. overstre@ohsu.edu
Westbrook
Gary L
GL
D000375:Aging / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000166:cytology / Q000254:growth & development*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D007473:Ion Channels