Polyplex-embedding in polyelectrolyte multilayers for gene delivery.
In this work, incorporation of plasmid DNA, pre-complexed with PEI, into polyelectrolyte multilayers has been studied to further develop platforms for local gene delivery. Polyplex embedding in synthetic and naturally degradable architectures was efficient for transfection of human hepato-cellular carcinoma cells.
Meyer
Florent
F
Inserm Unité 595, 11 rue Humann, F-67085 Strasbourg, France.
Ball
Vincent
V
Schaaf
Pierre
P
Voegel
Jean Claude
JC
Ogier
Joelle
J
D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D006801:Humans; D008113:Liver Neoplasms; D010957:Plasmids / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D014162:Transfection / Q000379:methods*
D004573:Electrolytes; D011094:Polyethyleneimine; D004247:DNA