Therapeutic efficacy of magnesium after acoustic trauma caused by gunshot noise in guinea pigs.
CONCLUSIONS
The present findings show that magnesium administration can significantly reduce threshold shift 7 days after gunshot noise exposure. However, this improvement seems to be temporary, suggesting a probable advantage in prolonging the treatment.


OBJECTIVE
To evaluate the therapeutic efficacy of magnesium administration after hearing loss induced by gunshot noise.


METHODS
Forty-eight guinea pigs were exposed to an impulse noise (blank shot from a rifle; 170 or 176 dB SPL peak). The therapeutic efficacy of magnesium was evaluated by administering either the treatment or a placebo to the traumatized animals for 7 days, beginning 1 h after the trauma. Auditory function was explored for up to 14 days of recovery by recording the compound action potential in the round window. The functional study of hearing was supplemented by histological analysis.


RESULTS
The threshold shifts of the 170-dB SPL group that received magnesium were significantly lower than those of controls after 2 and 7 days of recovery, but no significant difference was evidenced at 14 days in this group, nor at any time in the 176-dB SPL group. Animals treated with magnesium after the 176-dB SPL exposure had a significant reduction in hair cell loss in the basal region.
Sendowski
Isabelle
I
Pôle "Traumatisme Sonore", Département de Radiobiologie, Centre de Recherches du Service de Santé des Armées (CRSSA), La Tronche Cedex, France. Isendowski@crssa.net
Raffin
Florent
F
Braillon-Cros
Anne
A
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D005260:Female; D005389:Firearms; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy* / Q000209:etiology*; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D009925:Organ of Corti / Q000187:drug effects / Q000473:pathology; D011897:Random Allocation; D016896:Treatment Outcome
D008274:Magnesium