Killed Candida albicans yeasts and hyphae inhibit gamma interferon release by murine natural killer cells.
Killed yeasts and hyphae of Candida albicans inhibit gamma interferon secretion by highly purified murine NK cells in response to the Toll-like receptor ligands lipopolysaccharide and zymosan. This effect, which is also observed in the presence of NK-activating cytokines (interleukin-2 [IL-2], IL-12, and IL-15), may represent a novel mechanism of immune evasion that contributes to the virulence of C. albicans.
Murciano
Celia
C
Departamento de Microbiología y Ecología, Facultad de Ciencias Biológicas, Edificio de Investigación, C/ Dr. Moliner 50, 46100 Burjasot, Valencia, Spain.
Villamón
Eva
E
O'Connor
José-Enrique
JE
Gozalbo
Daniel
D
Gil
M Luisa
ML
D000818:Animals; D002176:Candida albicans / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D025301:Hyphae / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D007371:Interferon-gamma / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007378:Interleukins / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000235:genetics; D051197:Toll-Like Receptor 4 / Q000172:deficiency / Q000235:genetics; D015054:Zymosan / Q000276:immunology / Q000378:metabolism
D007378:Interleukins; D008070:Lipopolysaccharides; C493486:Tlr2 protein, mouse; C493487:Tlr4 protein, mouse; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D007371:Interferon-gamma; D015054:Zymosan