Proteomics: a paradigm shift.
Proteome--the protein complement of a genome--has become the protein renaissance and a key research tool in the post-genomic era. The basic technology involves the routine usage of gel electrophoresis and spectrometry procedures for deciphering the primary protein sequence/structure as well as knowing certain unique post-translational modifications that a particular protein has undergone to perform a specific function in the cell. However, the recent advancements in protein analysis have ushered this science to provide deeper, bigger and more valuable perspectives regarding performance of subtle protein-protein interactions. Applications of this branch of molecular biology are as vast as the subject is and include clinical diagnostics, pharmaceutical and biotechnological industries. The 21st century hails the use of products, procedures and advancements of this science as finer touches required for the grooming of fast-paced technology.
Kalia
Anu
A
Department of Microbiology Punjab Agricultural University, Ludhiana, Punjab, India. kaliaanu@rediffmail.com
Gupta
R P
RP
D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods* / Q000639:trends; D020869:Gene Expression Profiling / Q000379:methods* / Q000639:trends; D006801:Humans; D040081:Protein Array Analysis / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000379:methods* / Q000639:trends; D020539:Sequence Analysis, Protein / Q000379:methods* / Q000639:trends; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*