Comparison of different brands of IVIg in an in vitro model of immune neuropathy.
Intravenous immunoglobulin (IVIg) is used for the treatment of a number of autoimmune neurological disorders. Whether different brands of IVIg or different lots of the same brand are comparably efficacious for the treatment of neurological disorders is not clear. To examine this issue we compared the efficacy of different brands and/or lots of IVIg in a cell culture model of immune neuropathy. We report that products examined were equally effective and there was no lot-to-lot variability in our experimental model. These findings support the notion that efficacy of different IVIg products is comparable in a standardized model.
Zhang
Gang
G
Department of Neurology, Johns Hopkins University School of Medicine, 600 N-Wolfe Street, 509 Pathology Bldg., Baltimore, MD 21287, USA.
Lopez
Pablo H H
PH
Sheikh
Kazim A
KA
D001327:Autoimmune Diseases / Q000628:therapy*; D018929:Cell Culture Techniques / Q000379:methods; D045744:Cell Line, Tumor; D006801:Humans; D007118:Immunoassay / Q000379:methods; D016756:Immunoglobulins, Intravenous / Q000276:immunology* / Q000627:therapeutic use; D008954:Models, Biological; D010523:Peripheral Nervous System Diseases / Q000628:therapy*
D016756:Immunoglobulins, Intravenous