title: Acetyltrimethylsilane: a novel reagent for the transformation of 2H-pyran-2-ones to unsymmetrical biaryls.
abstract: [reaction: see text] An expeditious synthesis of unsymmetrical biaryls functionalized with electron-withdrawing or -donating substituents is described and illustrated by carbanion-induced ring transformation of 2H-pyran-2-one using acetyltrimethylsilane (ATMS) as a novel reagent in good yield. The novelty of the reaction lies in the creation of an aromatic ring from 2H-pyran-2-ones via two-carbon insertion from ATMS used as a source of carbanion.
authors.affiliation: Division of Medicinal and Process Chemistry and Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India. agoel13@yahoo.com
authors.forename: Atul
authors.initials: A
authors.lastname: Goel
authors.forename: Deepti
authors.initials: D
authors.lastname: Verma
authors.forename: Manish
authors.initials: M
authors.lastname: Dixit
authors.forename: Resmi
authors.initials: R
authors.lastname: Raghunandan
authors.forename: P R
authors.initials: PR
authors.lastname: Maulik
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D011753:Pyrones / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D011753:Pyrones; D012821:Silanes