[Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia].
OBJECTIVE
To investigate the association of estrogen receptor (ER) gene polymorphism and primary trigeminal neuralgia.


METHODS
By polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), ER gene polymorphism was analyzed in 20 trigeminal neuralgia (TR) patients and 20 control individuals, and the distribution of ER genotype was compared in TR group and control group.


RESULTS
There was no significant difference in frequencies of allele and genotype in XbaI or PvuII polymorphism or XbaI with PvuII polymorphisms together between TR group and control group (P > 0.05). The genotypic distribution of Xx or PpXx in TR group was higher than control group, and it was contary to xx, ppxx or Ppxx in TR group and control group.


CONCLUSIONS
XbaI or PvuII polymorphism may be related to TR. Women with PpXx genotype may be a dangerous factor to primary trigeminal neuralgia.
Huang
Cui-jiao
CJ
Dept of Radiology, West China College of Stomatology, Sichuan University, Chengdu, China.
Wang
Hu
H
Wu
Ming-yue
MY
Zhang
Jing-ju
JJ
Meng
Qing-rong
QR
Fu
Chun-hua
CH
Deng
Jian-zhong
JZ
Yi
Ping
P
D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen; D014277:Trigeminal Neuralgia
D011960:Receptors, Estrogen