N-oxide sensing and denitrification: the DNR transcription factors.
All denitrifiers can keep the steady-state concentrations of nitrite and nitric oxide (NO) below cytotoxic levels by controlling the expression of denitrification gene clusters by redox signalling through transcriptional regulators belonging to the CRP (cAMP receptor protein)/FNR (fumarate and nitrate reductase regulator) superfamily.
Rinaldo
S
S
Department of Biochemical Sciences 'A. Rossi Fanelli' and Istituto di Biologia e Patologia Molecolari -- CNR, University of Rome La Sapienza, P. le A. Moro 5, 00185 Rome, Italy. serena.rinaldo@uniroma1.it
Giardina
G
G
Brunori
M
M
Cutruzzolà
F
F
D000595:Amino Acid Sequence; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D005810:Multigene Family; D050901:Nitrate Reductase / Q000235:genetics / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism; D011549:Pseudomonas / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D013385:Succinate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D009573:Nitrites; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D009569:Nitric Oxide; D013385:Succinate Dehydrogenase; D050901:Nitrate Reductase