Amiodarone-induced hyperthyroidism in a patient with functioning papillary carcinoma of the thyroid and extensive hepatic metastases.
Thyroid hormone producing thyroid carcinoma is an uncommon cause of thyrotoxicosis. A patient with extensive hepatic metastases from well-differentiated carcinoma is presented. Administration of amiodarone for atrial fibrillation led to the development of hyperthyroidism. Precipitation of thyrotoxicosis by iodine-containing compounds in patients with thyroid carcinoma is rare. The relatively high iodine load and the slow elimination of amiodarone complicate the clinical management of such patients.
Mackie
Gavin C
GC
University of Michigan Medical Center, Ann Arbor, USA.
Shulkin
Barry L
BL
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D002291:Carcinoma, Papillary / Q000150:complications*; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D013964:Thyroid Neoplasms / Q000150:complications*; D013971:Thyrotoxicosis / Q000209:etiology*
D000638:Amiodarone