title: Effects of cessation of a policy of neonatal fluconazole prophylaxis on fungal resurgence.
abstract: Fluconazole has been used as prophylaxis against systemic fungal infections in preterm neonates. We conducted a study to determine whether cessation of a policy of prophylactic fluconazole results in a resurgence of fungal infections in a unit. Neonates born in the 3 epoches: A 36-month pre-Fluconazole prophylaxis epoch (Group 1), a 21-month Fluconazole prophylaxis epoch (Group 2) and a 39-month post Fluconazole prophylaxis epoch (Group 3) were compared for incidence and onset of fungal sepsis and resistance patterns. There was a decline in the incidence of fungal sepsis from Group 1 to Group 2, and it remained stable from Group 2 to Group 3. There was no significant difference in resistance to Fluconazole and to any of the azoles in Groups 1, 2 and 3 respectively.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160 012, India. sourabhdutta@yahoo.co.in
authors.forename: Sourabh
authors.initials: S
authors.lastname: Dutta
authors.forename: Srinivas
authors.initials: S
authors.lastname: Murki
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Varma
authors.forename: Anil
authors.initials: A
authors.lastname: Narang
authors.forename: Arunaloke
authors.initials: A
authors.lastname: Chakrabarti
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D016469:Fungemia / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal / Q000458:organization & administration; D008297:Male; D016134:Organizational Policy; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole