What are we looking for in new antibacterials and how do we design it?
The need for new antibacterial agents is a pressing, unmet medical need, but success has been limited, resulting in decreased business interest. Part of the problem is the lack of clarity regarding what would make a new-generation 'blockbuster' antibacterial and how this agent could be designed. To this end, the authors outline a few ideas regarding the changes in approach in order to accomplish these needs, including a fundamental change in the drug discovery process.
Barrett
John F
JF
Motyl
Mary
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000502:physiology; D015507:Drugs, Investigational / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D000900:Anti-Bacterial Agents; D015507:Drugs, Investigational