title: [Concentration of glutathione (GSH), ascorbic acid (vitamin C) and substances reacting with thiobarbituric acid (TBA-rs) in single human brain metastases].
abstract: The aim of the study was to estimate the concentration of glutathione (GSH), ascorbic acid (vitamin C) and thiobarbituric acid (TBA-rs) in single human brain metastases and histologically unchanged nerve tissue. The research was conducted on fragments of neoplasmatic tissue collected from 45 patients undergoing surgery in the Department of Neurosurgery, Medical University of Białystok in years 1996-2002. Concentration of GSH was evaluated using the GSH-400 method, vitamin C using the method of Kyaw and TBA-rs using the method of Salaris and Babs. It has been found that there is a decrease of concentration of GSH and vitamin C and a considerable increase (p < 0.05) of concentration of TBA-rs in investigated single brain human metastasis in correlation to the concentration of the mentioned above substances in unchanged nerve tissue.
authors.affiliation: Klinika Neurochirurgii, Akademii Medycznej w Białymstoku.
authors.forename: Henryk
authors.initials: H
authors.lastname: Dudek
authors.forename: Ryszard
authors.initials: R
authors.lastname: Farbiszewski
authors.forename: Maria
authors.initials: M
authors.lastname: Rydzewska
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Michno
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kozłowski
mesh_terms: D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000032:analysis*; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000556:secondary*; D005260:Female; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione; D001205:Ascorbic Acid