[Molecular mechanism of bone absorption in osteoclast].
The physiological reconstruction of bone is strictly dependent on bone resorption. Bone resorption is believed to be a complicated molecular reaction process that occurs in the microcircumstance of bone tissue. A lot of enzymes and factors take part in this process, yet there are not enough data with reference to the activation of osteoclast, resorption of bone matrix, regulation of bone resorption. In this paper we review the importance of matrix metalloproteinases (MMPs) in transfer of osteoclast and degradation of bone matrix, and the function of receptor activator of NF-kappaB-ligand (RANKL) and osteoprotegerin (OPG) in regulation of bone resorption.
Zhang
Bingbing
B
Key Laboratory of Biomechanics & Tissue Engineering , Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, China.
Pan
Jun
J
Deng
Xiaoyan
X
Zhao
Jianhua
J
Wang
Yuanliang
Y
D001862:Bone Resorption; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D010010:Osteoclasts / Q000502:physiology*; D053244:Osteoprotegerin / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology*
D053244:Osteoprotegerin; D053245:RANK Ligand; C505688:TNFSF11 protein, human; D020782:Matrix Metalloproteinases