title: The CAREGENE study: polymorphisms of the beta1-adrenoceptor gene and aerobic power in coronary artery disease.
abstract: OBJECTIVE
  The heritability of aerobic power and of the response to physical training has been shown in healthy subjects. beta(1)-Adrenergic receptor (beta(1)AR) function affects exercise performance. This study aims to investigate whether the Ser49Gly and Gly389Arg polymorphisms of the beta(1)AR gene or their haplotypes are associated with aerobic power or its response to physical training in coronary artery disease (CAD).
  
  
  RESULTS
  Nine hundred and thirty-five biologically unrelated Caucasian patients with CAD who had exercised until exhaustion during graded bicycle testing at baseline and after completion of 3 months of exercise training from 1990 to 2001 (n = 1095) were eligible for inclusion in the CAREGENE (CArdiac REhabilitation and GENetics of Exercise performance) study. Polymorphisms were detected using the invader assay (Third Wave Technologiestrade mark, Madison, Wisconsin, USA). Patients with the Gly49Gly genotype had significantly higher covariate-adjusted aerobic power at baseline than those with Ser49Ser and Ser49Gly (P < 0.05). Adjusted aerobic power at baseline was highest in the Ser49-Gly389/Gly49-Gly389 and Gly49-Arg389/Gly49-Arg389 haplotype combinations. Aerobic power increased significantly (P < 0.001) with physical training. There was no association with the effect of physical training.
  
  
  CONCLUSIONS
  Ser49Gly and haplotype combinations of Ser49Gly and Gly389Arg of the beta(1)AR gene are associated with aerobic power, but not with the response to physical training in patients with CAD included in the CAREGENE study.
authors.affiliation: Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, Leuven, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Defoor
authors.forename: Kevin
authors.initials: K
authors.lastname: Martens
authors.forename: Dominika
authors.initials: D
authors.lastname: Zielinska
authors.forename: Gert
authors.initials: G
authors.lastname: Matthijs
authors.forename: Hilde
authors.initials: H
authors.lastname: Van Nerum
authors.forename: Dirk
authors.initials: D
authors.lastname: Schepers
authors.forename: Robert
authors.initials: R
authors.lastname: Fagard
authors.forename: Luc
authors.initials: L
authors.lastname: Vanhees
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*
chemical_list: D018342:Receptors, Adrenergic, beta-1