title: Investigation of fundo-antral reflex in human beings.
abstract: OBJECTIVE
  To examine the sensory and motor response(s) of the stomach following fundic distention and to assess whether cholinergic mechanisms influence these responses.
  
  
  METHODS
  Fundic tone, gastric sensory responses and antral motility were evaluated in eight healthy volunteers after a probe with two sensors was placed in the antrum and a highly compliant balloon in the fundus. Isobaric balloon distentions were performed with a barostat. Study was repeated in six volunteers after intravenous atropine was given.
  
  
  RESULTS
  Fundic distention induced large amplitude antral contractions in all subjects. The area under the curve was higher (P<0.05) during fundic distention. First sensation was reported at 12+/-4 mmHg, moderate sensation at 18+/-4 mmHg and discomfort at 21+/-4 mmHg. Discomfort was associated with a decrease in antral motility. After atropine was given, the area under the curve of pressure waves and fundic tone decreased (P<0.05). Sensory thresholds were not affected.
  
  
  CONCLUSIONS
  Fundic balloon distention induces an antral motor response, the fundo-antral reflex, which in part may be mediated by cholinergic mechanisms.
authors.affiliation: Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. satish-rao@uiowa.edu
authors.forename: Satish S C
authors.initials: SS
authors.lastname: Rao
authors.forename: Anjana
authors.initials: A
authors.lastname: Kumar
authors.forename: Brent
authors.initials: B
authors.lastname: Harris
authors.forename: Bruce
authors.initials: B
authors.lastname: Brown
authors.forename: Konrad S
authors.initials: KS
authors.lastname: Schulze
mesh_terms: D000328:Adult; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D013271:Gastric Dilatation; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D008365:Manometry; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology; D011312:Pressure; D011706:Pyloric Antrum / Q000187:drug effects / Q000502:physiology*; D012018:Reflex; D012677:Sensation / Q000502:physiology; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
chemical_list: D018727:Muscarinic Antagonists; D001285:Atropine