title: Practical method for transforming alkynes into alpha-diketones.
abstract: [reaction: see text] Oxidation of alkynes to alpha-dicarbonyl derivatives through a convenient one-pot procedure via a Brønsted acid-promoted "hydration" and a DMSO-based oxidation sequence has been achieved in high yields. The scope and limitations of the reaction have also been investigated.
authors.affiliation: Global Chemical Process Research and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. wanzh@lilly.com
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Wan
authors.forename: Chauncey D
authors.initials: CD
authors.lastname: Jones
authors.forename: David
authors.initials: D
authors.lastname: Mitchell
authors.forename: John Y
authors.initials: JY
authors.lastname: Pu
authors.forename: Tony Y
authors.initials: TY
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D004121:Dimethyl Sulfoxide; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction
chemical_list: D000480:Alkynes; D007202:Indicators and Reagents; D007659:Ketones; D004121:Dimethyl Sulfoxide