title: Nanotechnologies for biomolecular detection and medical diagnostics.
abstract: Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.
authors.affiliation: Division of Hematology and Oncology, Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus OH 43210-1002, USA.
authors.forename: Mark Ming-Cheng
authors.initials: MM
authors.lastname: Cheng
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cuda
authors.forename: Yuri L
authors.initials: YL
authors.lastname: Bunimovich
authors.forename: Marco
authors.initials: M
authors.lastname: Gaspari
authors.forename: James R
authors.initials: JR
authors.lastname: Heath
authors.forename: Haley D
authors.initials: HD
authors.lastname: Hill
authors.forename: Chad A
authors.initials: CA
authors.lastname: Mirkin
authors.forename: A Jasper
authors.initials: AJ
authors.lastname: Nijdam
authors.forename: Rosa
authors.initials: R
authors.lastname: Terracciano
authors.forename: Thomas
authors.initials: T
authors.lastname: Thundat
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D019937:Diagnostic Techniques and Procedures / Q000295:instrumentation*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods; D012680:Sensitivity and Specificity; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001704:Biopolymers; D012825:Silicon