title: [Mechanism of CD4+CD25+ and CD8+ regulatory T cells--review].
abstract: Regulatory T cells (Treg) play a key role in the negative regulation of the immune system, which can inhibit inappropriate self-reactive T cells, as well as limit the range, extent and lasting time of immune responses, so as to inhibit the proliferation of CD4(+) and CD8(+) effector T cells. In view of these properties, there is little doubt about the enormous potential value of Tregs in molecular mechanisms and clinical treatment of human autoimmune disorders, graft-versus-host disease (GVHD) and allergies. In this review, the molecular mechanisms of CD4(+)CD25(+) Treg and CD8(+) Treg were mainly discussed, and challenge with which study on Treg cells is faced and prospects were briefly described.
authors.affiliation: Department of Hematology, The First Hospital of Peking University, Beijing 10034, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ou
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D053645:Interleukin-2 Receptor alpha Subunit