Reliability of rapid urinary test for antibody to Helicobacter pylori in adult patients with proteinuria.
A urinary test for detecting the anti-H. pylori antibody using immunochromatography (RAPIRAN) is considered suitable for the screening purpose. However, this may yield spurious results in the presence of proteinuria. The present study was conducted to evaluate the diagnostic performance of RAPIRAN in patients with proteinuria. Urine and serum samples of adult inpatients with proteinuria were used for analyses. The diagnosis of H. pylori infection was made based on the seropositivity of anti-H. pylori antibody using 2 different serum tests. Fifty-one subjects were eligible for analyses. The serum tests showed negative and positive in 25 and 26 patients, respectively. Two of 25 seropositive patients had a negative result in RAPIRAN, and 1 provided invalid data. All of seronegative patients showed negative in RAPIRAN. The overall accuracy was 95.0%. The present study showed that RAPIRAN has diagnostic quality enough to use clinically also in patients with proteinuria.
Yamamoto
Takatsugu
T
Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173-8605, Japan. ymmttktg@cameo.plala.or.jp
Kojima
Kenichiro
K
Sanaka
Masaki
M
Ishii
Taro
T
Osaki
Yukako
Y
Tsutsumi
Hiroko
H
Tsuchiya
Akihiko
A
Kuyama
Yasushi
Y
Uchida
Shunya
S
D000328:Adult; D000907:Antibodies, Bacterial / Q000652:urine*; D002846:Chromatography, Affinity / Q000379:methods*; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000150:complications*; D012680:Sensitivity and Specificity
D000907:Antibodies, Bacterial