title: Evaluation of sentinel node identification with isosulfan blue in gastric cancer.
abstract: OBJECTIVE
  The aim of this study was to clarify whether the metastasis of gastric cancer can be detected by identifying the sentinel lymph nodes (SNs) using only lymphatic dye.
  
  
  METHODS
  The study was based on 101 patients clinically diagnosed with T1 and T2 gastric cancer. Isosulfan blue was intraoperatively injected within the submucosal layer around the lesion through an endoscope and blue stained nodes (BNs) were identified as SNs and harvested. Standard radical gastrectomy with D2 lymphadenectomy was performed on all patients and SNs and other nodes were evaluated.
  
  
  RESULTS
  Out of 101 patients, 21 had lymph-node metastases. The accuracy of SN identification was 97.0% (98/101) and the metastasis detection rate was 85.7% (18/21). With improvement of the manoeuvre in the latter 84 cases, the detection rate was elevated up to 100.0% (18/18), as was the accuracy (84/84).
  
  
  CONCLUSIONS
  The sentinel concept using lymphatic dye is applicable to gastric cancer, but the identification of SNs with lymphatic dye requires some practice. Furthermore, the issue of intraoperative metastasis detection remains to be resolved.
authors.affiliation: Department of Surgery, Shikoku Cancer Center, 13 Horinouchi, Matsuyama, Ehime 790-0007, Japan. hca01333@nifty.com
authors.forename: M
authors.initials: M
authors.lastname: Ishizaki
authors.forename: A
authors.initials: A
authors.lastname: Kurita
authors.forename: Y
authors.initials: Y
authors.lastname: Kubo
authors.forename: S
authors.initials: S
authors.lastname: Takashima
authors.forename: T
authors.initials: T
authors.lastname: Nishina
authors.forename: E
authors.initials: E
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004396:Coloring Agents; D005188:False Negative Reactions; D005260:Female; D005629:Frozen Sections; D005743:Gastrectomy; D006801:Humans; D015994:Incidence; D007633:Keratins; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012394:Rosaniline Dyes; D021701:Sentinel Lymph Node Biopsy; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery
chemical_list: D004396:Coloring Agents; D012394:Rosaniline Dyes; C025484:iso-sulfan blue; D007633:Keratins