Factors influencing nerve regeneration in a trial of timcodar dimesylate.
The authors assessed the ability of the neurophilin compound, timcodar dimesylate, to accelerate the return of epidermal nerve fiber density (ENFD) after a standardized nerve injury in a randomized double blind, placebo controlled trial. While there was no difference in the regeneration rate between the treatment and placebo arms, the baseline ENFD (p = 0.006), height (p = 0.02), and race (p = 0.03) were associated with the regeneration rate.
Polydefkis
M
M
Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA. mpolyde@jhmi.edu
Sirdofsky
M
M
Hauer
P
P
Petty
B G
BG
Murinson
B
B
McArthur
J C
JC
D000328:Adult; D001706:Biopsy; D004311:Double-Blind Method; D004817:Epidermis / Q000294:innervation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009416:Nerve Regeneration / Q000187:drug effects*; D017288:Pain Threshold; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology; D011725:Pyridines / Q000627:therapeutic use*; D012684:Sensory Thresholds; D013848:Thigh; D014110:Touch; D014947:Wounds and Injuries / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology
D011725:Pyridines; C494139:timcodar