Determination of l-methamphetamine: a case history.
Methamphetamine was detected in a 77-year-old male who had a history of congestive heart failure. Using a modification of a previously reported method, trifluoroacetyl-l-prolyl chloride was used to derivatize sympathomimetic amines to allow separation and identification of individual enantiomers. The l-enantiomer of methamphetamine and a trace amount of l-amphetamine were found in blood and urine specimens from this case. Further investigation revealed the decedent had bronchial asthma and regularly used a Vicks Inhaler, which contains l-methamphetamine as the active ingredient.
Wyman
John F
JF
Franklin County Coroner's Office, Columbus, OH 43201, USA. jfwyman@franklincountyohio.gov
Cody
John T
JT
D000280:Administration, Inhalation; D000368:Aged; D000661:Amphetamine / Q000097:blood; D001249:Asthma / Q000188:drug therapy; D017809:Fatal Outcome; D005554:Forensic Medicine; D006801:Humans; D019570:Inhalation Exposure; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000097:blood*; D013237:Stereoisomerism
D008694:Methamphetamine; D000661:Amphetamine