title: Metabolic and endocrine disturbances in psychiatric disorders: a multidisciplinary approach to appropriate atypical antipsychotic utilization.
abstract: Patients with psychiatric disorders have an increased rate of cardiovascular morbidity and mortality compared with the general population. Metabolic issues such as weight gain, dyslipidemia, diabetes mellitus, diabetic ketoacidosis,and pancreatitis have been reported with the use of antipsychotic agents. Although atypical antipsychotics have not been linked directly to the development of metabolic syndrome, these medications have been shown to increase risk factors that can lead to metabolic and endocrine disturbances. Therefore, clinicians should provide ongoing monitoring for patients who are being treated for psychiatric disorders with these agents. According to the 2004 Consensus Report on Antipsychotics, screening measures should include baseline and follow-up monitoring of personal/family histories, weight (body mass index), waist circumference, blood pressure, fasting plasma glucose, and fasting lipid profile.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Prakash S
authors.initials: PS
authors.lastname: Masand
authors.forename: Larry
authors.initials: L
authors.lastname: Culpepper
authors.forename: David
authors.initials: D
authors.lastname: Henderson
authors.forename: Scott
authors.initials: S
authors.lastname: Lee
authors.forename: Kimberly
authors.initials: K
authors.lastname: Littrell
authors.forename: John W
authors.initials: JW
authors.lastname: Newcomer
authors.forename: Natalie
authors.initials: N
authors.lastname: Rasgon
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000175:diagnosis; D004700:Endocrine System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced* / Q000175:diagnosis; D009203:Myocardial Infarction / Q000139:chemically induced / Q000175:diagnosis; D010348:Patient Care Team; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents