Prognostic significance of ischemia modified albumin after percutaneous coronary intervention.
Ischemia modified albumin (IMA) is a new biochemical marker of ischemia. IMA levels rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is unclear whether IMA elevations correlate with PCI variables. The possible prognostic value of post-PCI IMA elevation has not yet to be studied.


METHODS
We studied 60 patients (mean age 61 years; 51 male) who underwent successful elective single-vessel PCI for the management of stable angina pectoris. IMA levels were measured and compared with PCI variables and target lesion revascularization rate. The median post-PCI follow up is 46 months (CI 44.6 to 47.7).


RESULTS
We found that the only variable related to post-PCI IMA levels was periprocedural dissection of target vessel (147.6 vs. 141.1 kU/l, p=0.035). No correlation between high and low balloon inflation pressure (143.6 vs. 141.6 kU/l, p=0.64), short and long inflation pressure (141.5 vs. 143.6 kU/l, p=0.17), with and without stent placement (143.7 vs. 141.3 kU/l, p=0.93) was found. IMA level more then 130 kU/l was associated with higher frequency of target lesion revascularization at nearly 4-years follow-up (p=0.026).


CONCLUSIONS
Post-PCI IMA elevation is associated with higher target lesion revascularization.
Dusek
Jaroslav
J
First Department of Internal Medicine, University Hospital Hradec Králové, Czech Republic. dusek@fnhk.cz
St'ásek
Josef
J
Tichý
Milos
M
Bis
Josef
J
Gregor
Jaroslav
J
Vojácek
Jan
J
Masín
Vladimír
V
Polanský
Pavel
P
Brtko
Miroslav
M
Cernohorský
Dusan
D
D000418:Albumins / Q000378:metabolism*; D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000097:blood / Q000473:pathology; D011379:Prognosis
D000418:Albumins