Effect of curcumin on the expression of LDL receptor in mouse macrophages.
To investigate the molecular mechanisms of lipid-lowering drug, Rhizoma Curcumae Longae, we treated the mouse macrophages with curcumin, which was purified from the ethanol extraction of Rhizoma Curcumae Longae. The LDL receptors expressed in the macrophages were determined by ELISA, FLISA and assay of LDL uptake. Here for the first time, we found that curcumin obviously up-regulated the expression of LDL receptor in mouse macrophages, and the dose-effect relationship was demonstrated.
Fan
Chunlei
C
Institute of Molecular Medicine, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053, China. taijispear@126.com
Wo
Xingde
X
Qian
Ying
Y
Yin
Jin
J
Gao
Liping
L
D000818:Animals; D002460:Cell Line; D003474:Curcumin / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D011973:Receptors, LDL / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects
D011973:Receptors, LDL; D003474:Curcumin