title: Cooperative binding and self-assembling behavior of cationic low molecular-weight dendrons with RNA molecules.
abstract: Tri(ethylene glycol) derived, low molecular-weight dendrons with various amine end groups were synthesized and characterized for their properties of binding and self-assembling with RNA using the Candida ribozyme as a model RNA molecule. These dendritic compounds form stable complexes and well-defined nanoscale particles with RNA molecules via electrostatic interactions and self-assembly process, while leaving the other terminal of the tri(ethylene glycol) chain accessible for targeting. This suggests that dendrimers of this type hold great promise for specific RNA targeting and RNA delivery.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.
authors.forename: Jiehua
authors.initials: J
authors.lastname: Zhou
authors.forename: Jiangyu
authors.initials: J
authors.lastname: Wu
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: Liu
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Mu
authors.initials: M
authors.lastname: Xiao
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Laurence
authors.initials: L
authors.lastname: Charles
authors.forename: Cheng-Cai
authors.initials: CC
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D002175:Candida / Q000201:enzymology; D002412:Cations / Q000737:chemistry; D002942:Circular Dichroism; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D008970:Molecular Weight; D049329:Nanostructures; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
chemical_list: D002412:Cations; D050091:Dendrimers; C028914:triethylene glycol; D011092:Polyethylene Glycols; D012313:RNA; D008274:Magnesium