title: [Protective effects of urinastatin on organ function in patients with severe burn].
abstract: OBJECTIVE
  To investigate the protective effects of urinastatin on organ function in severe burn.
  
  
  METHODS
  Seventy-two cases with comparative severity in burn injury were randomly divided into urinastatin treatment group (n=36) and control group (n=36). Patients in control group received routine therapy, while those in treatment group received intravenous dripping of urinastatin twice a day for 5 to 7 days. The dosage of urinastatin was 300 kU in severe burns and 200 kU in moderate burns. Both polyvinylpyrrolidone iodine (PVP-I) and Jiedu Shaoshang cream were used for wound dressing. The clinical findings were assessed and variables indicating functions of internal organs, including liver (alanine aminotransferase), kidney (blood urea nitrogen, serum creatinine), heart (aspartate aminotransferase, lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, creatine kinase, isoenzymes of creatinine kinase), and coagulation (prothrombin time, international normalized ratio, activated partial thromboplastin time, fibrinogen), as well as blood routine test, troponin, myoglobin, arterial blood analysis, bacteria culture were measured.
  
  
  RESULTS
  In treatment group, vital signs and general condition were satisfactory at shock phase and peri-operative stages in all the patients. Edema of burn wound subsided rapidly. The 28-day mortality rate was 0. There was significant difference between the two groups (all P<0.05).
  
  
  CONCLUSIONS
  Urinastatin has protective effects on multiple organs in severe burn injury.
authors.affiliation: Department of Burn, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, Guangdong, China.
authors.forename: Ying-bin
authors.initials: YB
authors.lastname: Xu
authors.forename: Shao-hai
authors.initials: SH
authors.lastname: Qi
authors.forename: Ju-lin
authors.initials: JL
authors.lastname: Xie
authors.forename: Ji-shan
authors.initials: JS
authors.lastname: Yuan
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Shu
authors.forename: Po
authors.initials: P
authors.lastname: Liu
authors.forename: Tian-zeng
authors.initials: TZ
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000517:prevention & control; D014361:Trypsin Inhibitors / Q000627:therapeutic use*; D055986:Vital Signs; D055815:Young Adult
chemical_list: D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin