title: A novel dendritic cell subset involved in tumor immunosurveillance.
abstract: The interferon (IFN)-gamma-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice. Here we show that the main source of IFN-gamma is not the conventional NK cell but a subset of B220(+)Ly6C(-) dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220(+)NK1.1(+) dendritic cells secrete high levels of IFN-gamma and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2(-/-)Il2rg(-/-) mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.
authors.affiliation: ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Taieb
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chaput
authors.forename: Cédric
authors.initials: C
authors.lastname: Ménard
authors.forename: Lionel
authors.initials: L
authors.lastname: Apetoh
authors.forename: Evelyn
authors.initials: E
authors.lastname: Ullrich
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bonmort
authors.forename: Marie
authors.initials: M
authors.lastname: Péquignot
authors.forename: Noelia
authors.initials: N
authors.lastname: Casares
authors.forename: Magali
authors.initials: M
authors.lastname: Terme
authors.forename: Caroline
authors.initials: C
authors.lastname: Flament
authors.forename: Paule
authors.initials: P
authors.lastname: Opolon
authors.forename: Yann
authors.initials: Y
authors.lastname: Lecluse
authors.forename: Didier
authors.initials: D
authors.lastname: Métivier
authors.forename: Elena
authors.initials: E
authors.lastname: Tomasello
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
authors.forename: François
authors.initials: F
authors.lastname: Martin
authors.forename: David
authors.initials: D
authors.lastname: Klatzmann
authors.forename: Thierry
authors.initials: T
authors.lastname: Poynard
authors.forename: Thomas
authors.initials: T
authors.lastname: Tursz
authors.forename: Graça
authors.initials: G
authors.lastname: Raposo
authors.forename: Hideo
authors.initials: H
authors.lastname: Yagita
authors.forename: Bernard
authors.initials: B
authors.lastname: Ryffel
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D017951:Antigen Presentation; D000950:Antigens, Ly; D000954:Antigens, Surface / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins / Q000276:immunology; D039521:CD11c Antigen / Q000378:metabolism; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics; D003713:Dendritic Cells / Q000145:classification* / Q000276:immunology* / Q000648:ultrastructure; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis; D053631:Interleukin Receptor Common gamma Subunit; D007694:Killer Cells, Natural / Q000276:immunology; D037181:Lectins, C-Type / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008819:Mice, Nude; D008854:Microscopy, Electron; D055651:NK Cell Lectin-Like Receptor Subfamily B; D009374:Neoplasms, Experimental / Q000276:immunology*; D018123:Receptors, Interleukin / Q000172:deficiency / Q000235:genetics; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000950:Antigens, Ly; D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D039521:CD11c Antigen; D004268:DNA-Binding Proteins; C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit; C527211:Klrb1c protein, mouse; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D055651:NK Cell Lectin-Like Receptor Subfamily B; C499308:Rag2 protein, mouse; D018123:Receptors, Interleukin; D053221:TNF-Related Apoptosis-Inducing Ligand; C505654:Tnfsf10 protein, mouse; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D017493:Leukocyte Common Antigens