[Study on the antipyretic, analgesic effects of qingkailing freeze-dried powder for injection and its antipyretic mechanism].
OBJECTIVE
To investigate the antipyretic, analgesic effects of Qingkailing Freeze-Dried Powder for Injection (QI) and its mechanism of the antipyretic effect.


METHODS
The rabbit model of 2, 4-dinitrophenol-induced fever and the rat model of endotoxin-induced fever were established and the body temperatures were observed. Radioimmunoassay was adopted to detect the levels of IL-1beta and cAMP in the hypothalamus of rats. The analgesic effects were tested by hot-plate and writhing reaction method.


RESULTS
QI showed marked antipyretic effects on the 2,4-dinitrophenol-induced fever and the endotoxin-induced fever. At the same time, QI remarkably decreased the contents of IL-beta and cAMP in the hypothalamus. QI also remarkably reduced the frequency of acetic acid-induced writhing and delaied the time of licking rear feet.


CONCLUSIONS
QI has antipyretic, analgesic effects. Its mechanism of the antipyretic effects on rats may be inhibiting the production of IL-1beta and accordingly decreasing cAMP in the hypothalamus.
Li
Dong
D
West China School of Basic Medical Sciences and Forensic Medicine of Sichuan University, Chengdu 610041.
Yang
Fangju
F
Huang
Jihua
J
Ling
Jing
J
Jing
Yan
Y
D019297:2,4-Dinitrophenol; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000473:pathology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry*; D011208:Powders; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D011208:Powders; D000242:Cyclic AMP; D019297:2,4-Dinitrophenol