[Prostate cancer diagnosis using 24 cores extended biopsy].
OBJECTIVE
To determine the diagnostic performance of extended prostatic biopsy (PB) in prostate cancer (PC) and variables affecting positivity.


METHODS
Patients (n = 147) underwent 24 cylinder PB at the Arquitecto Marcide Hospital, Ferrol, La Coruña, between December 2002-September 2004. Inclusion criteria were the following: patients aged < or = 70 with one or more negative PB or aged < or = 75 with two or more negative PB. An univariate analysis was carried out using the chi-squared test for the qualitative variables and the t-Student and U Mann-Whitney tests in the case of the quantitative variables, plus a logistical regression analysis in order to identify those variables related to the extended PB positivity.


RESULTS
60 patients (40.82%) were identified as having PC. Significant differences were observed in prostatic volume, free/total PSA ratio in the initial PB, free/total PSA ratio in the extended PB, PSA-density in the extended PB as well as the existence of chronic prostatitis in previous PB. During the multivariate analysis it was found that the PSA-density and the presence of chronic prostatitis in previous PB independently predicted the positivity of the extended PB.


CONCLUSIONS
Extended PB allows for the detection of PC in 40.82% of patients with previous negative PB. The increase in PSA density is associated with a greater probability of PC, whilst the existence of chronic prostatitis in prior PB significantly reduces the probability of PC in the extended PB.
Rodríguez Alonso
A
A
Servicios de Urología, Hospital Arquitecto Marcide, Ferrol, La Coruña. arodri68@terra.es
González Blanco
A
A
Pita Fernandez
S
S
Suárez Pascual
G
G
Bonelli Martín
C
C
Lorenzo Franco
J
J
Alvarez Fernández
J C
JC
Cuerpo Pérez
M A
MA
D000368:Aged; D001707:Biopsy, Needle / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*