Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR.
A 28-day in vivo treatment trial to evaluate the efficacy of pyrimethamine/sulfadoxine (Fansidar, PS) was conducted in 21 Lao patients with uncomplicated Plasmodium falciparum malaria. Sixteen patients (76%) were completely cured with PS without any reappearance of asexual stage parasitemia during the follow-up examination. On the other hand, 5 patients (24%) failed to respond to this trial medication, resulting in recrudescence of asexual stage P. falciparum malaria. PS resistance resulted in higher prevalence of post-treatment gametocytemia, 25% gametocyte carriers among PS sensitive cases versus 75% of the resistant cases. These findings suggest that although the level of PS resistance is still valid for treatment of malaria in the study area of Lao PDR, post-treatment induction of gametocytemia among resistant cases may result an increase in transmission rate of PS resistant falciparum malaria.
Mannoor
M Kaiissar
MK
Division of Tropical Parasitology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. kaiissar@med.u-ryukyu.ac.jp
Vanisaveth
Viengxay
V
Keokhamphavanh
Boualy
B
Toma
Hiromu
H
Watanabe
Hisami
H
Kobayashi
Jun
J
Hatabu
Toshimitsu
T
Taguchi
Nao
N
Hongvangthong
Bousy
B
Phetsouvanh
Rattanaxay
R
Phompida
Samlane
S
Kano
Shigeyuki
S
Sato
Yoshiya
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007812:Laos; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D013413:Sulfadoxine; D011739:Pyrimethamine