title: N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis.
abstract: In this report, we describe a new family of N-thiolated 2-oxazolidinones having antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus anthracis. The effect of ring substituents and stereochemistry on antibacterial activity of these oxazolidinones closely parallels that previously reported for N-thiolated beta-lactam antibiotics.
authors.affiliation: Department of Chemistry, 4202 East Fowler Avenue, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Mishra
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Revell
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Coates
authors.forename: Edward
authors.initials: E
authors.lastname: Turos
authors.forename: Sonja
authors.initials: S
authors.lastname: Dickey
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Lim
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013438:Sulfhydryl Compounds; D047090:beta-Lactams