title: Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants.
abstract: OBJECTIVE
  To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin reuptake inhibitors (SSRIs) in utero.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Tertiary care center. Patients One hundred twenty term infants, of whom 60 had prolonged in utero exposure to SSRIs, including paroxetine hydrochloride, fluoxetine, citalopram hydrobromide, sertraline hydrochloride, and venlafaxine hydrochloride.
  
  
  METHODS
  Neonatal abstinence syndrome was assessed with the Finnegan score as follows: score of 8 or above, severe; score of 4 to 7, mild; and score of 0 to 3, normal. All infants were followed up with a standardized protocol that included repeated Finnegan score assessments and cardiorespiratory monitoring until normalization of the Finnegan score.
  
  
  RESULTS
  Of the 60 neonates exposed to SSRIs in utero, 8 showed severe and 10 showed mild symptoms of a neonatal abstinence syndrome. All nonexposed neonates had a normal Finnegan score. In neonates who developed severe symptoms, the maximum mean daily Finnegan scores were recorded within 2 days after birth, although maximum individual scores were recorded as long as 4 days after birth.
  
  
  CONCLUSIONS
  Neonatal abstinence syndrome occurs in 30% of neonates exposed to SSRIs in utero. These neonates should be monitored for at least 48 hours after birth. The long-term effects of prolonged exposure to SSRIs, particularly in neonates who develop severe symptoms, have yet to be determined.
authors.affiliation: Neonatal Intensive Care Unit, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petah Tiqwa, Israel 49202.
authors.forename: Rachel
authors.initials: R
authors.lastname: Levinson-Castiel
authors.forename: Paul
authors.initials: P
authors.lastname: Merlob
authors.forename: Nehama
authors.initials: N
authors.lastname: Linder
authors.forename: Lea
authors.initials: L
authors.lastname: Sirota
authors.forename: Gil
authors.initials: G
authors.lastname: Klinger
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009357:Neonatal Abstinence Syndrome / Q000453:epidemiology* / Q000209:etiology*; D011247:Pregnancy; D015995:Prevalence; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors