title: [Chemotherapy in advanced non small cell lung cancer].
abstract: Lung cancer is the world's first cause of death by cancer. Locally advanced and metastatic non small cell cancers represent 2/3rd of cases at diagnosis and are of worst prognosis. We conducted a retrospective study of 202 patients to investigate the effect of chemotherapy on survival and quality of life. 95 patients received chemotherapy with VP16-CDDP (88%) or Gemcitabin-CDDP. Improvement survival was observed in the chemotherapy group: 8 month IC 95% [6.6-9.3] 4 month IC 95% [3.1-4.9] in the control group. Chemotherapy also had a good perfect on the quality of life with improvement of performance status, symptoms and need of analgesic. However although significant, the role of chemotherapy in NSCLC remains modest and new therapeutic approaches are needed including prevention and early detection which are probably more effective and cheaper.
authors.affiliation: Service de pneumologie et d'allergologie, EPS Futtouma Bourguiba Monastir, Tunisie.
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Battikh
authors.forename: Samah
authors.initials: S
authors.lastname: Joobeur
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Ben Sayah
authors.forename: Naceur
authors.initials: N
authors.lastname: Rouatbi
authors.forename: Wahid
authors.initials: W
authors.lastname: Braham
authors.forename: Anis
authors.initials: A
authors.lastname: Maatallah
authors.forename: Monia
authors.initials: M
authors.lastname: Daami
authors.forename: Jalila
authors.initials: J
authors.lastname: Souissi
authors.forename: Monia
authors.initials: M
authors.lastname: Hammouda
authors.forename: Ali
authors.initials: A
authors.lastname: El-Kamel
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate