title: In vitro evaluation of no carrier added, carrier added and cross-complexed [90Y]-EDTMP provides evidence for a novel "foreign carrier theory".
abstract: The present study focused on the preparation of novel bone tracers containing yttrium as radionuclide or carrier. Moreover, these preparations were comparatively evaluated in vitro on the basis of a recently presented pre vivo model comprising binding studies on synthetic and human bone powder. It was shown that among the therapeutic radionuclides, no carrier added [(90)Y]-EDTMP exceeded [(188)Re]-EDTMP while yielding lower binding values than [(153)Sm]-EDTMP. Furthermore, the authors investigated the influence of "foreign" carriers added to [(90)Y]-EDTMP, [(99m)Tc]-EDTMP and [(111)In]-EDTMP by the method of cross-complexation. The findings reveal a new paradigm: a carrier more foreign to the complexed radionuclide causes a higher binding increase on human bone matrices in vitro than a more "related" carrier.
authors.affiliation: Department of Nuclear Medicine, Medical University of Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Toegel
authors.forename: Leonhard-Key
authors.initials: LK
authors.lastname: Mien
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wadsak
authors.forename: Harald
authors.initials: H
authors.lastname: Eidherr
authors.forename: Helmut
authors.initials: H
authors.lastname: Viernstein
authors.forename: Rainer
authors.initials: R
authors.lastname: Kluger
authors.forename: Dagmar
authors.initials: D
authors.lastname: Ettlinger
authors.forename: Kurt
authors.initials: K
authors.lastname: Kletter
authors.forename: Robert
authors.initials: R
authors.lastname: Dudczak
authors.forename: Markus
authors.initials: M
authors.lastname: Mitterhauser
mesh_terms: D001842:Bone and Bones / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry*; D019317:Evidence-Based Medicine; D006801:Humans; D066298:In Vitro Techniques; D009942:Organometallic Compounds / Q000737:chemistry* / Q000493:pharmacokinetics*; D063065:Organophosphonates / Q000737:chemistry* / Q000493:pharmacokinetics*; D011485:Protein Binding; D015021:Yttrium Radioisotopes
chemical_list: D004337:Drug Carriers; D009942:Organometallic Compounds; D063065:Organophosphonates; D015021:Yttrium Radioisotopes; C061699:yttrium ethylenediaminetetra(methylenephosphonic acid)