title: Influence of HBcAg in liver cell plasma on expression of transforming growth factor-beta 1 in liver tissue of low-grade chronic hepatitis B patients.
abstract: OBJECTIVE
  To study the influence of HBcAg on the expression of transforming growth factor-beta 1 (TGF-beta1) in liver tissue of low-grade chronic hepatitis B (CHB) patients.
  
  
  METHODS
  The expression of TGF-beta1 and HBcAg in liver samples from 93 low-grade CHB patients was detected by immunohistochemistry and valuated by semi-quantitative scoring.
  
  
  RESULTS
  In the 93 low-grade CHB patients, HBcAg was expressed in cell plasma but not in the liver tissue. There was no significant difference between the two groups.
  
  
  CONCLUSIONS
  The expression of TGF-beta1 is not related with HBcAg expressed as plasma type in the tissues of low-grade CHB patients.
authors.affiliation: Department of Clinical Hepatitis, Tianjin Infectious Disease Hospital, Tianjin 300192, China. ygwx@public.tpt.tj.cn
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Liu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Lu
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Wang
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Yang
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Lang
authors.forename: Xin
authors.initials: X
authors.lastname: Meng
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Jun-Qiang
authors.initials: JQ
authors.lastname: Li
authors.forename: Chen-Zhao
authors.initials: CZ
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006512:Hepatitis B Core Antigens / Q000032:analysis*; D019698:Hepatitis C, Chronic / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000032:analysis*; D053773:Transforming Growth Factor beta1
chemical_list: D006512:Hepatitis B Core Antigens; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1