title: Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes.
abstract: BACKGROUND
  Careful follow-up of children born after in vitro maturation (IVM) of human oocytes is essential because the technique is still very new.
  
  
  METHODS
  Obstetric and perinatal data were collected from all deliveries after IVM treatment during 1999-2004. The growth and development of IVM children was assessed at 6, 12 and 24 months using Muenchener Funktionelle Entwicklungs Diagnostik and Bayley Scales of Infants.
  
  
  RESULTS
  In total, 43 women [age 31.2 +/- 3.9 (mean +/- SD) years] gave birth to 40 singleton infants and three sets of twins (multiple rate 7.0%). Obstetric complications occurred in 15 pregnancies (35%). The mean birthweight of singleton infants was 3550 +/- 441 g and that of twins 2622 +/- 194 g. The rate of preterm birth infants was 5% in singletons. No perinatal deaths occurred. At the age of 12 months, eight children (19%) expressed minor developmental problems and one girl was found to have optical glioma. At 2 years of age, neuropsychological development was within the normal range.
  
  
  CONCLUSIONS
  The obstetric and perinatal outcome was good, and the mean birthweight of the infants was normal. Minor developmental delay was overexpressed at 12 months, but the development of the children was normal at 2 years.
authors.affiliation: The Family Federation of Finland, Infertility Clinic, Helsinki, Finland. viveca.soderstrom-anttila@vaestoliitto.fi
authors.forename: Viveca
authors.initials: V
authors.lastname: Söderström-Anttila
authors.forename: Teija
authors.initials: T
authors.lastname: Salokorpi
authors.forename: Miia
authors.initials: M
authors.lastname: Pihlaja
authors.forename: Silve
authors.initials: S
authors.lastname: Serenius-Sirve
authors.forename: Anne-Maria
authors.initials: AM
authors.lastname: Suikkari
mesh_terms: D000328:Adult; D002658:Developmental Disabilities / Q000209:etiology; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009865:Oocytes / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D014427:Twins