The application of aqueous solutions of products of alternating oxypropylene- and oxyethylenating n-ols as a solubilizer for selected sterols.
The process of equilibrium solubility of sterols (cholesterol, cholic acid, hydrocortisone) by aqueous solutions of Rokanols was investigated. Critical micellar concentration (cmc) and thermodynamic potential of micellarization (deltaG(m)0) were determined for aqueous solutions of Rokopols RF-55, RF-33, TG-500 and R-330. The solubility activity of aqueous solutions of Rokopols was defined by calculation from the viscosity measurements of solubility index n(sol) for cholesterol, cholic acid and hydrocortisone. The amount of solubilized hydrocortisone by Rokopol micelles was determined by a spectrophotometric method.
Zgoda
Marian Mikołaj
MM
Department of Drug Form Technology, Applied Pharmacy Faculty, Medical University, Lódź. mmzgoda@pharm.am.lodz.pl
Nachajski
Michał
M
D000438:Alcohols / Q000737:chemistry*; D006854:Hydrocortisone / Q000032:analysis / Q000737:chemistry; D008823:Micelles; D012995:Solubility; D012996:Solutions / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D000438:Alcohols; D008823:Micelles; D012996:Solutions; D013261:Sterols; D014867:Water; D006854:Hydrocortisone