title: Serum lipid and lipoprotein alterations represent recovery of liver function after hepatectomy.
abstract: BACKGROUND
  The assessment of liver function during human liver regeneration is necessary to prevent unexpected liver failure and to prepare for further treatment. We selected patients prospectively and measured serum lipid and lipoprotein levels to identify which lipids and lipoproteins could represent recovery of liver function in human liver regeneration.
  
  
  METHODS
  Thirty selected patients who underwent hepatectomy were divided into three groups depending on the serum hyaluronate (HA) level and the type of liver resection.
  
  
  RESULTS
  We found three patterns of lipid and lipoprotein alterations after hepatectomy. Among the lipids and lipoproteins examined, the serum beta-lipoprotein and low-density lipoprotein (LDL) levels were significantly different among the groups at 7 days after hepatectomy. The alteration of the apolipoprotein (Apo) B level was similar to that of LDL. The LDL level was correlated with both beta-lipoprotein and Apo B before hepatectomy (r=0.653 and 0.894, respectively) and at 7 days after hepatectomy (r=0.841 and 0.943, respectively).
  
  
  CONCLUSIONS
  Serum HA before hepatectomy can reflect postoperative liver function depending on the type of liver resection. Recovery of the beta-lipoprotein and LDL levels can reflect the recovery of liver function in human liver regeneration within the early period in association with the Apo B level.
authors.affiliation: Department of Surgery I, Sapporo Medical University Hospital, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Toru
authors.initials: T
authors.lastname: Mizuguchi
authors.forename: Minoru
authors.initials: M
authors.lastname: Nagayama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nobuoka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Taishi
authors.initials: T
authors.lastname: Sato
authors.forename: Kazumitsu
authors.initials: K
authors.lastname: Koito
authors.forename: Susan
authors.initials: S
authors.lastname: Parker
authors.forename: Tadashi
authors.initials: T
authors.lastname: Katsuramaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D006498:Hepatectomy; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008111:Liver Function Tests; D008115:Liver Regeneration / Q000502:physiology*; D008875:Middle Aged; D020127:Recovery of Function / Q000502:physiology*
chemical_list: D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D006820:Hyaluronic Acid