[Progress in the study on diacylgycerol acyltransferase (DGAT)-related genes].
Diacylgycerol Acyltransferase (DGAT) plays an important role in the formation of lipid in different tissues of biological body. DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycerol. This enzyme is coded by both DGAT1 and DGAT2. DGAT1 belongs to the gene family of cholesterol acyltransferase (ACAT). DGAT2 belongs to the gene family of monoacylgycerol acyltransferases (MGAT1). This paper reviewed the structure, location on chromosome and biological effect of DGAT-related genes. The relationship between polymorphism and performance of animal was also discussed.
Ma
Hai-Ming
HM
College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China. mahaiming2000@163.com
Shi
Qi-Shun
QS
Liu
Xiao-Chun
XC
D000214:Acyl Coenzyme A / Q000378:metabolism; D000217:Acyltransferases / Q000235:genetics; D000818:Animals; D051048:Diacylglycerol O-Acyltransferase / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D004075:Diglycerides / Q000378:metabolism; D016678:Genome / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000378:metabolism
D000214:Acyl Coenzyme A; D004075:Diglycerides; D014280:Triglycerides; D000217:Acyltransferases; D051048:Diacylglycerol O-Acyltransferase; C459903:MGAT1 protein, mouse; D017351:N-Acetylglucosaminyltransferases