Intestinal diffuse large B-cell lymphoma associated with celiac disease: a Japanese case.
Intestinal non-Hodgkin's lymphoma (NHL), especially the T-cell type, is well known to be associated with celiac disease (CD), an enteropathic disorder with a propensity for certain racial and genetic backgrounds. CD is typically characterized by gastrointestinal (GI) symptoms, anti-transglutaminase antibodies in the sera, and microscopical findings of the intestinal mucosa, which resolve with a gluten-free diet (GFD). In Asian populations, including the Japanese, CD and the associated NHL have been supposed to be quite rare, and studies concerning the frequency of CD or its relationship with NHL are scarce. We describe a Japanese middle-aged man with intestinal diffuse large B-cell lymphoma associated with CD. Following multi-combined chemotherapy, the patient's lymphoma has been in a state of complete response, and his GI symptoms have improved with a GFD. This case suggests that the possibility of CD and its association with intestinal NHL should be kept in mind, even in Asian populations.
Makishima
Hideki
H
The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Ito
Toshiro
T
Kodama
Ryo
R
Asano
Naoko
N
Nakazawa
Hideyuki
H
Hirabayashi
Kazuko
K
Nakamura
Shigeo
S
Ota
Masao
M
Akamatsu
Taiji
T
Kiyosawa
Kendo
K
Ishida
Fumihiro
F
D000368:Aged; D002446:Celiac Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D007564:Japan; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D012074:Remission Induction