title: Prognostic factors for progression of visual field damage in patients with normal-tension glaucoma.
abstract: OBJECTIVE
  To evaluate the rate of progression and the prognostic factors of visual field damage in patients with normal-tension glaucoma (NTG).
  
  
  METHODS
  Ninety-two NTG patients (92 eyes) were followed up for more than 2 years with topical antiglaucoma medications. All subjects were classified as having early damaged eyes with an initial mean deviation (MD) of -6 dB or better, moderately damaged eyes with MD between -6 dB and -12 dB, and severely damaged eyes with MD of -12 dB or worse, and survival data were analyzed using regression analysis based on the Cox proportional hazards model.
  
  
  RESULTS
  The probability of visual field stability was significantly higher in patients with moderate damage than in those with severe damage (P = 0.035). The patients with early damage showed no difference in the probability of visual field stability compared with patients with moderate or severe damage. The progression of visual field damage was significantly associated with mean intraocular pressure (IOP) (P = 0.000) or IOP fluctuation (P = 0.002) during follow-up regardless of the severity of the initial visual field damage.
  
  
  CONCLUSIONS
  The rate of progression of visual field damage differed according to the severity of the initial visual field damage. IOP reductive medication may be effective in preventing glaucomatous visual field progression in patients with NTG.
authors.affiliation: Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan. nakagami@med.nihon-u.ac.jp
authors.forename: Takako
authors.initials: T
authors.lastname: Nakagami
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Fukuko
authors.initials: F
authors.lastname: Hayamizu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014786:Vision Disorders / Q000188:drug therapy / Q000503:physiopathology*; D014794:Visual Fields
chemical_list: D000959:Antihypertensive Agents