title: Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC.
abstract: The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.
authors.affiliation: Departamento de Ciencias Farmacéuticas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors.forename: Rosario
authors.initials: R
authors.lastname: Rojas
authors.forename: Betty
authors.initials: B
authors.lastname: Bustamante
authors.forename: Palmira
authors.initials: P
authors.lastname: Ventosilla
authors.forename: Irma
authors.initials: I
authors.lastname: Fernádez
authors.forename: Luz
authors.initials: L
authors.lastname: Caviedes
authors.forename: Robert Henry
authors.initials: RH
authors.lastname: Gilman
authors.forename: Olga
authors.initials: O
authors.lastname: Lock
authors.forename: Gerald Bruce
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology*; D001681:Biological Assay; D003465:Culex; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010568:Peru; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D000995:Antitubercular Agents; D007306:Insecticides