title: Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats.
abstract: The effect of pre-germinated brown rice (PGBR) on cholesterol metabolism was studied in Donryu rats subcutaneously implanted with the ascites hepatoma cell line AH109A and compared with that of white rice (WR). The effect of brown rice (BR), the source of PGBR, was also studied. Hepatoma-bearing rats fed a WR diet exhibited hypercholesterolemia compared with normal rats fed the same diet. Feeding hepatoma-bearing rats a PGBR or BR diet suppressed hepatoma-induced hypercholesterolemia, and enhanced fecal bile acid excretion and the activity of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme of bile acid biosynthesis, in the microsomal fraction of the liver without affecting cholesterol synthesis in the host liver of hepatoma-bearing rats. These results suggest that PGBR as well as BR suppresses hypercholesterolemia induced by hepatoma growth by up-regulating cholesterol catabolism.
authors.affiliation: Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo 183-8509, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Miura
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Ito
authors.forename: Aya
authors.initials: A
authors.lastname: Mizukuchi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kise
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Aoto
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yagasaki
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000032:analysis / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D018525:Germination; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000201:enzymology / Q000209:etiology; D008114:Liver Neoplasms, Experimental / Q000150:complications / Q000378:metabolism*; D009368:Neoplasm Transplantation; D012275:Oryza / Q000254:growth & development; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001647:Bile Acids and Salts; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase