title: Solvent free microwave synthesis and evaluation of antimicrobial activity of pyrimido[4,5-b]- and pyrazolo[3,4-b]quinolines.
abstract: A series of 2-oxopyrimido[4,5-b]-, 2-thio[4,5-b]-, 1-(p-tosyl)pyrazolo[3,4-b]- and 1-(2',4'-dinitrophenyl)pyrazolo[3,4-b]-quinolines have been synthesized in good to excellent yields by environmentally benign solvent free microwave-induced techniques involving the condensation of 2-chloro-3-formylquinolines with urea, thiourea, p-toluenesulfonylhydrazide and 2,4-dinitrophenylhydrazine, respectively, using PTSA as a catalyst. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. Most of the compounds showed the best activity against Escherichia coli and Pseudomonas aeruginosa.
authors.affiliation: Department of Chemistry (PG and Research), Kongunadu Arts and Science College, G.N. Mills Post, Coimbatore 641029, India. thamaraimohan@yahoo.co.in
authors.forename: Senniappan Thamarai
authors.initials: ST
authors.lastname: Selvi
authors.forename: Vetrivel
authors.initials: V
authors.lastname: Nadaraj
authors.forename: Sellappan
authors.initials: S
authors.lastname: Mohan
authors.forename: Raju
authors.initials: R
authors.lastname: Sasi
authors.forename: Manoharan
authors.initials: M
authors.lastname: Hema
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D002384:Catalysis; D004926:Escherichia coli / Q000187:drug effects; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D013237:Stereoisomerism
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011720:Pyrazoles; D011721:Pyrenes; D011743:Pyrimidines; D011804:Quinolines; C041343:1,3,6,8-pyrene tetrasulfonate