Polyhydroxylated 4-thiaflavans as multipotent antioxidants: protective effect on oxidative DNA damage in vitro.
Hydroxylated 4-thiaflavans, possessing the antioxidant features of catechol containing flavonoids and/or tocopherols, were evaluated as protective agents against oxidation damage induced in herring sperm DNA by cumene hydroperoxide (CumOOH) or by the glutathione/ferric ion (GSH/Fe(3+)) system. Our data indicate that the effective protection exerted by some of the tested compounds is overall higher than those provided by catechin and alpha-tocopherol, which might be attributed both to the scavenging properties and chelation of Fe(2+) ions.
Lodovici
Maura
M
Dipartimento di Farmacologia, Università di Firenze, Viale Pieraccini 6, I-50139, Firenze, Italy. maura.lodovici@unifi.it
Menichetti
Stefano
S
Viglianisi
Caterina
C
Caldini
Silvia
S
Giuliani
Elisa
E
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004249:DNA Damage; D005290:Ferric Compounds / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D006900:Hydroxylation; D018384:Oxidative Stress; D013056:Spectrophotometry, Ultraviolet
D000975:Antioxidants; D005290:Ferric Compounds; D005419:Flavonoids; D005978:Glutathione