Cerebral amyloid angiopathy presenting with vasculitic pathology.
We present an elderly patient with an unusual extensive multifocal central nervous system mass lesion, with dramatic imaging changes but only minor disturbance of cerebral function. Cerebral biopsy revealed an unexpected finding of severe cerebral amyloid angiopathy with secondary florid vasculitic appearances, which is a very rare but recognised association. Immunosuppression has produced significant sustained clinical and radiological remission.
Wong
S H
SH
Department of Neurology and Clinical Neurophysiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia.
Robbins
P D
PD
Knuckey
N W
NW
Kermode
A G
AG
D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures; D014057:Tomography, X-Ray Computed; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
D016229:Amyloid beta-Peptides; D007166:Immunosuppressive Agents