title: Labeling of acetaminophen with I-131 and biodistribution in rats.
abstract: The aim of the present study was to label acetaminophen (APAP) with I-131 and to determine its radiopharmaceutical potential in rats. Acetaminophen was labeled with I-131 using the iodogen method. The radiochemical purity of (131)I-APAP was determined by RTLC and paper electrophoresis. The labeling yield was 94 +/- 4%. The biodistribution studies of the labeled compound (specific activity; 56.60 GBq/mmol) were performed in male Albino Wistar rats. The uptake of (131)I-APAP in some organs were determined at different time after injection to the rats. The radioactivity in each organ was counted and the percentage of injected activity per gram of tissue weight (%ID/g) for each organ and blood was calculated. (131)I-APAP uptake in the lung, liver, kidneys, pancreas, blood, stomach and some brain region, were observed. Thus, (131)I-APAP may be radiopharmaceutical for the imaging of the brain.
authors.affiliation: Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Izmir, Turkey. fatma.yurt.lambrecht@ege.edu.tr
authors.forename: Fatma Yurt
authors.initials: FY
authors.lastname: Lambrecht
authors.forename: Kubra
authors.initials: K
authors.lastname: Durkan
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Yildirim
authors.forename: Cigdem
authors.initials: C
authors.lastname: Acar
mesh_terms: D000082:Acetaminophen / Q000737:chemistry / Q000493:pharmacokinetics*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D004590:Electrophoresis, Paper; D006207:Half-Life; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008297:Male; D000442:Octanols / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents; D014018:Tissue Distribution; D014867:Water / Q000737:chemistry
chemical_list: D018712:Analgesics, Non-Narcotic; D007457:Iodine Radioisotopes; D000442:Octanols; D012997:Solvents; D014867:Water; D000082:Acetaminophen