title: Arsenic speciation transported through the placenta from mother mice to their newborn pups.
abstract: The primary goal of the present study was to confirm the arsenic species that can be transferred from the mother to the bodies of newborn pups through the placenta and the speciated arsenic distribution in the liver and brain of newborn mice after gestational maternal exposure to inorganic arsenic (iAs). Mother mice were exposed to iAsIII and iAsV in drinking water during gestation. The livers and brains of the mother mice and their newborn pups were taken. Contents of iAs, monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and trimethylarsenic (TMA) compound were detected using the HG-AAS method. Contents of iAs, MMA, and DMA in the liver of mother mice increased with the concentration of arsenite or arsenate in their drinking water. However, only DMA increased with the concentration of arsenate or arsenite in the drinking water in the brain of mother mice. On the other hand, contents of both iAs and DMA in the liver and brain of newborn mice increased with the concentration of arsenate or arsenite administered to their mother orally. Contents of arsenic species in the liver and brain of both mother mice and their newborn pups were significantly lower in the 10 ppm iAsV group than in the 10 ppm iAsIII group. Ratios of iAs or DMA levels between the brain and the liver of newborn mice were larger than 1, whereas those in mother mice were much smaller than 1. iAs taken from drinking water was distributed and metabolized mainly in the liver of mother mice. iAsIII in low levels may be taken up and metabolized easily in the liver compared to iAsV. Both iAs and DMA are transferred from the mother through the placenta and cross the immature blood-brain barrier (BBB) easily. Compared to that in the liver of newborn mice, DMA as an organic metabolite is prevalent in brain, a lipidic organ, if the BBB is not matured enough to prevent it from entering the brain.
authors.affiliation: Department of Environmental and Occupational Health, College of Public Health, China Medical University, Shenyang, Liaoning 110001, PR China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Jin
authors.forename: Shuhua
authors.initials: S
authors.lastname: Xi
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Chunwei
authors.initials: C
authors.lastname: Lu
authors.forename: Gexin
authors.initials: G
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xu
authors.forename: Chunqing
authors.initials: C
authors.lastname: Qu
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Niu
authors.forename: Guifan
authors.initials: G
authors.lastname: Sun
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001151:Arsenic / Q000378:metabolism; D001152:Arsenicals / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D005260:Female; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D051379:Mice; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D001152:Arsenicals; D014874:Water Pollutants, Chemical; D001151:Arsenic