title: The first reported cases of disseminated histoplasmosis in Cambodia, complicated by multiple opportunistic infections.
abstract: Although disseminated histoplasmosis is recognized as a common opportunistic infection in HIV-infected persons living in endemic areas, it is not widely reported in Southeast Asia, and has not been reported in Cambodia. It remains unanswered whether this is secondary to a low disease prevalence, or whether the disease, which is associated with a nonspecific clinical presentation, is under diagnosed. In addition to a review of the literature regarding histoplasmosis in Southeast Asia, we provide a description of two HIV-1 infected patients with documented disseminated histoplasmosis complicating other opportunistic infections in Phnom Penh, Cambodia. These two cases highlight the need for both a high clinical suspicion, and reliable laboratory testing, in a setting where there is likely to be more than one infection complicating the patient's clinical course.
authors.affiliation: University Research Co LLC, Phnom Penh, Cambodia.
authors.forename: K
authors.initials: K
authors.lastname: Bun Navy
authors.forename: S
authors.initials: S
authors.lastname: Prem Prey
authors.forename: L
authors.initials: L
authors.lastname: Lynen
authors.forename: P
authors.initials: P
authors.lastname: Sovanna
authors.forename: J D
authors.initials: JD
authors.lastname: Bell
authors.forename: J I
authors.initials: JI
authors.lastname: Harwell
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002160:Cambodia / Q000453:epidemiology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole