[Clinical studies of vaccine TEOVac under the conditions of remote revaccination].
In the clinical trials of vaccine TEOVac in lower and reglamented doses under the conditions of remote vaccination, carried out on 11 volunteers, local reactions in the form of hyperemia, gingival edema (1 vaccinee), faucial hyperemia, enlargement of submaxillary lymph nodes (2 vaccinees) were registered in some of the vaccines; in one vaccinee systemic postvaccinal reaction of medium gravity was observed. Revaccination produced no negative effect on the hematological and biochemical characteristics of the blood, as well as on the urine characteristics. The study of the sensitizing vaccine to the antigens of the accumulation substrate (chick embryo), as well as its influence on the development of autoimmune reactions, revealed the absence of the allergic action of the preparation and its influence on autoimmune processes in the vaccines. The trial of the smallpox vaccine in tablets under the conditions of the primary immunization of adults was the topical and most promising trend in the improvement of smallpox vaccination, as the preparation TEOVac proved to be safe, in contrast to the traditional smallpox vaccine introduced by the scarification method, for both vaccines and nonimmunized persons having contacts with them.
Mel'nikov
S A
SA
Podkuĭko
V N
VN
Khamitov
R A
RA
Maksimov
V A
VA
Markov
V I
VI
Vorob'ev
A A
AA
Shagarov
E E
EE
Shul'ga
S V
SV
Chernikova
N K
NK
Kharchenko
T N
TN
Rodionova
M P
MP
D000284:Administration, Oral; D000328:Adult; D004487:Edema / Q000473:pathology; D005260:Female; D005881:Gingiva / Q000473:pathology; D005882:Gingival Diseases / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D007117:Immunization, Secondary / Q000009:adverse effects*; D008198:Lymph Nodes; D008199:Lymphadenitis / Q000139:chemically induced; D008297:Male; D012899:Smallpox / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D013363:Submandibular Gland; D013607:Tablets; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects
D012900:Smallpox Vaccine; D013607:Tablets; D014613:Vaccines, Attenuated