title: [Main principles of antibiotic prophylaxis and antibacterial therapy in abdominal surgery].
abstract: The principles of antibioticoprophylaxis and antibacterial therapy in abdominal surgery were expounded. There are adduced the most frequently revealed pathogenic microorganisms, inducing intraabdominal infection, the ways of lowering of the antibacterial therapy expenses, new approaches to application of immunocorrection and directed transport of antibiotics in surgery as well as empirical and etiotropic treatment, basing on the taking account of the spread and antibioticosensitivity of pathogenic microorganisms of nosocomial infections. There was shown, that concentration of interleucin-1beta and tumor necrosis factor-alpha in the blood serum is connected with the severity of patient state. Significant rising of this cytokines concentration constitutes the trustworthy criterion of the ineffective therapy and mortality risk. The influence of microorganisms and some antibiotics on induction of interferons was studied. Amoxicyllin, polymixin, vancomycin, cephalosporins and fluconazol are the most active inductors of gamma-interferon. Maximal efficacy of antibacterial therapy is possible only if an adequate surgical intervention was performed.
authors.forename: V F
authors.initials: VF
authors.lastname: Saenko
authors.forename: E B
authors.initials: EB
authors.lastname: Medvetskiĭ
authors.forename: A A
authors.initials: AA
authors.lastname: Stasenko
authors.forename: V A
authors.initials: VA
authors.lastname: Deev
authors.forename: A P
authors.initials: AP
authors.lastname: Mazur
authors.forename: I V
authors.initials: IV
authors.lastname: Khomiak
authors.forename: A V
authors.initials: AV
authors.lastname: Kubashko
mesh_terms: D034841:Abdominal Cavity / Q000601:surgery*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D006801:Humans; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents