title: A concise total synthesis of naamidine A.
abstract: [reaction: see text]. A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect to the preparation of analogues. Formation of the 2-aminoimidazole core is achieved by condensation of the appropriate alpha-aminoketone with cyanamide.
authors.affiliation: Medicinal Chemistry Group, The Walter and Eliza Hall Institute of Medical Research, Biotechnology Centre, 4 Research Avenue, Bundoora 3086, Victoria, Australia.
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Aberle
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lessene
authors.forename: Keith G
authors.initials: KG
authors.lastname: Watson
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry
chemical_list: D001688:Biological Products; D007093:Imidazoles; C114816:naamidine A