Expression of zinc finger protein ZPR1 mRNA in brain is up-regulated in mice fed a high-fat diet.
A differential display was performed to analyze differential gene expression in the brain of mice in association with dietary high beef tallow. Consumption of a high beef tallow diet up-regulated the expression of zinc finger protein ZPR1 mRNA in the brain. Expression of ZPR1 mRNA in the cerebellum and hippocampus was elevated in response to the high beef tallow diet. The increased ZPR1 expression in the neuronal, Neuro-2A cells, caused a significant increase in H(2)O(2)-induced cell death. These results suggest that a high beef tallow diet up-regulates ZPR1 mRNA expression in the brain and might increase the vulnerability to oxidative stress.
Nogusa
Yoshihito
Y
Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University, Higashi, Japan.
Yanaka
Noriyuki
N
Sumiyoshi
Naoki
N
Takeda
Keiko
K
Kato
Norihisa
N
D000818:Animals; D000906:Antibodies; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005223:Fats / Q000008:administration & dosage / Q000494:pharmacology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006861:Hydrogen Peroxide / Q000494:pharmacology; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D015854:Up-Regulation / Q000187:drug effects* / Q000235:genetics
D000906:Antibodies; D002352:Carrier Proteins; D004041:Dietary Fats; D005223:Fats; D047908:Intracellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C490987:Zfp259 protein, mouse; C013698:tallow; D006861:Hydrogen Peroxide