[Clinical observation of daidzein intervention on serum inflammatory factors in senile patients with coronary heart disease].
OBJECTIVE
To observe the effect of daidzein on serum inflammatory factors of senile patients with coronary heart disease (CHD).


METHODS
Forty senile patients with CHD were randomly assigned into the control group and the daidzein group, 20 in each group. Patients in both groups were treated with conventional medicine, while those in the daidzein group were given daidzein Tablets additionally for 6 weeks. The levels of resting heart rate (RHR), blood pressure (BP), fasting plasma glucose (FPG), blood lipids and inflammatory factors, including hsCRP, IL-6 and TNF-alpha, were measured before and after treatment.


RESULTS
In the control group, the levels of RHR, BP and hsCRP changed after conventional medicinal treatment (P < 0.05 or P < 0.01) but other parameters unchanged (P > 0.05). While in the daidzein group, all the parameters measured were decreased in different degrees after 6 weeks treatment (P < 0.05 or P < 0.01), and also showed significant difference as compared with those in the control group respectively (P < 0.05 or P < 0.01).


CONCLUSIONS
Daidzein can effectively decrease the levels serum inflammatory factors in senile patients with CHD, the fact proved that isoflavone has anti-inflammatory effect in patients with coronary atherosclerosis.
Liu
Ping
P
Department of Cardiovascular Diseases, Qilu Hospital of Shandong University, Jinan.
Zhao
Yu-Xia
YX
Zhang
Yun
Y
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D048789:Phytoestrogens / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015850:Interleukin-6; D007529:Isoflavones; D048789:Phytoestrogens; D014409:Tumor Necrosis Factor-alpha; C004742:daidzein; D002097:C-Reactive Protein