title: Persistent neuroinvasive West Nile virus infection in an immunocompromised patient.
abstract: A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.
authors.affiliation: Department of Epidemiology, Methodist Hospital, Omaha, Nebraska, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Penn
authors.forename: Jeannette
authors.initials: J
authors.lastname: Guarner
authors.forename: James J
authors.initials: JJ
authors.lastname: Sejvar
authors.forename: Herbert
authors.initials: H
authors.lastname: Hartman
authors.forename: Rodney D
authors.initials: RD
authors.lastname: McComb
authors.forename: Diana L
authors.initials: DL
authors.lastname: Nevins
authors.forename: Julu
authors.initials: J
authors.lastname: Bhatnagar
authors.forename: Sherif R
authors.initials: SR
authors.lastname: Zaki
mesh_terms: D000956:Antigens, Viral / Q000302:isolation & purification; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007136:Immunoglobulins / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000302:isolation & purification; D014901:West Nile Fever / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D007136:Immunoglobulins; D012367:RNA, Viral