title: Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevis.
abstract: The study of the chemical constituents of the roots of Newbouldia laevis (Bignoniaceae) has resulted in the isolation and characterization of a naphthoquinone-anthraquinone coupled pigment named newbouldiaquinone A (1) together with 14 known compounds: apigenin, chrysoeriol, newbouldiaquinone, lapachol, 2-methylanthraquinone, 2-acetylfuro-1,4-naphthoquinone, 2,3-dimethoxy-1,4-benzoquinone, oleanolic acid, canthic acid, 2-(4-hydroxyphenyl)ethyl triacontanoate, newbouldiamide, 5,7-dihydroxydehydroiso-alpha-lapachone, beta-sitosterol, and beta-sitosterol glucopyranoside. The structure elucidation of the isolated compounds was established based on spectroscopic studies, notably of the 2D NMR spectra. The antimalarial activity of compound (1) against Plasmodium falciparum in vitro shows moderate chemo suppression of parasitic growth. Its antimicrobial activity against a wide range of microorganisms was 13- and 24-fold more active against Candida gabrata and Enterobacter aerogens than the reference antibiotics nystatin and gentamycin.
authors.affiliation: Department of Organic Chemistry, Yaounde University I, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Kenneth Oben
authors.initials: KO
authors.lastname: Eyong
authors.forename: Gabriel Ngosong
authors.initials: GN
authors.lastname: Folefoc
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Veronique Penlap
authors.initials: VP
authors.lastname: Beng
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Augustin Ephram
authors.initials: AE
authors.lastname: Nkengfack
authors.forename: Michael
authors.initials: M
authors.lastname: Saeftel
authors.forename: Salem Ramadan
authors.initials: SR
authors.lastname: Sarite
authors.forename: Achim
authors.initials: A
authors.lastname: Hoerauf
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry*; D008517:Phytotherapy; D010860:Pigments, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000962:Antimalarials; D004987:Ethers; D009285:Naphthoquinones; D010860:Pigments, Biological; C509955:newbouldiaquinone A