title: Transanal endoscopic microsurgery in rectal adenomas: experience of six Italian centres.
abstract: OBJECTIVE
  Transanal endoscopic microsurgery is a minimally invasive technique that allows the excision of benign and selected malignant tumours. We present a study for evaluating surgical morbidity, mortality and local recurrence rate of patients with rectal adenomas treated with transanal endoscopic microsurgery in six different Italian centres following the same protocol.
  
  
  METHODS
  A total of 882 patients with rectal lesions (adenomas and early stage of carcinomas) underwent transanal endoscopic microsurgery in six different Surgical Departments from January 1993 to October 2004. Five hundred and ninety patients had preoperative diagnosis of adenomas but 588 patients were regularly followed up to determine treatment efficacy in terms of local recurrence rate.
  
  
  RESULTS
  The study involved 588 patients, with a median age of 66 years (25th percentile-75th percentile=58-71 years). No postoperative mortality was reported. Intraoperative complications were observed in three patients (0.5%). Minor complications occurred in 48 patients (8.2%) whereas major complications were found only in 7 patients (1.2%). Definitive histology confirmed adenomas in 530 cases (90.1%). Two patients (0.3%) were lost to follow-up so were not included in the paper. At median follow-up of 44 months (25th percentile-75th percentile=15-74 months), 23 (4.3%) adenomas recurred and were successfully retreated by transanal endoscopic microsurgery [20 cases (87%)] and by conventional surgery [3 patients (13%)]. No further recurrences were observed at subsequent follow-up. Thirty-one (5.3%) patients died during follow-up for old age, cardiac disease, etc.
  
  
  CONCLUSIONS
  Transanal endoscopic microsurgery is, in our experience, an effective method for local resection of benign rectal tumours with morbidity of 11.4%, no postoperative mortality and with a percentage of local recurrence of 4.3%.
authors.affiliation: Department of General Surgery, University of Ancona, "Umberto I" Hospital, Via Conca, 60020 Ancona, Italy. guerrieri.m@libero.it
authors.forename: M
authors.initials: M
authors.lastname: Guerrieri
authors.forename: M
authors.initials: M
authors.lastname: Baldarelli
authors.forename: M
authors.initials: M
authors.lastname: Morino
authors.forename: M
authors.initials: M
authors.lastname: Trompetto
authors.forename: A
authors.initials: A
authors.lastname: Da Rold
authors.forename: I
authors.initials: I
authors.lastname: Selmi
authors.forename: M E
authors.initials: ME
authors.lastname: Allaix
authors.forename: G
authors.initials: G
authors.lastname: Lezoche
authors.forename: E
authors.initials: E
authors.lastname: Lezoche
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000368:Aged; D002277:Carcinoma / Q000601:surgery; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012004:Rectal Neoplasms / Q000601:surgery*; D012086:Reoperation