title: Synthesis of 9-[1-(1 -hydroxyethyl)-3-(phosphonomethoxy)propyl]adenine and prodrug as possible antiviral agents.
abstract: The appropriately protected C-1'-hydroxyethyl-3-hydroxypropyl-N9-adenine nucleoside was prepared from 1-pivaloyloxy-5-tert-butyldiphenylsilyloxy-3-pentanol and adenine through the Mitsunobu reaction. One of the terminal hydroxyls was converted to the phosphonomethoxy derivative and the prodrug.
authors.affiliation: BioCryst Pharmaceuticals Inc., Birmingham, AL 35244, USA.
authors.forename: Ajit
authors.initials: A
authors.lastname: Ghosh
authors.forename: Yahya
authors.initials: Y
authors.lastname: El-Kattan
authors.forename: Minwan
authors.initials: M
authors.lastname: Wu
authors.forename: Tsu-Hsing
authors.initials: TH
authors.lastname: Lin
authors.forename: Satish
authors.initials: S
authors.lastname: Vadlakonda
authors.forename: Pravin L
authors.initials: PL
authors.lastname: Kotian
authors.forename: Yarlagadda S
authors.initials: YS
authors.lastname: Babu
authors.forename: Pooran
authors.initials: P
authors.lastname: Chand
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects / Q000254:growth & development*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D011355:Prodrugs; D000225:Adenine