title: Complete donor chimaerism of Langerhans cells in lymph node early after allogeneic bone marrow transplantation.
abstract: Host-derived Langerhans cells (LCs) are crucial antigen-presenting cells that cause graft-vs.-host disease after allogeneic haematopoietic stem cell transplantation (HSCT). However, chimaerism of LCs after allogeneic HSCT is largely unknown in humans. We here report a case that developed dermatopathic lymphadenitis accompanied by an accumulation of donor-derived LCs in the second month after allogeneic HSCT with reduced-intensity conditioning. This is the first case to show that donor LCs have the ability to migrate into draining lymph nodes and replace host LCs early after HSCT in humans.
authors.affiliation: First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Shichishima
authors.forename: Takanori
authors.initials: T
authors.lastname: Teshima
authors.forename: Kazuei
authors.initials: K
authors.lastname: Ogawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakamura-Shichishima
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tajima
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Noji
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Takeyama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
authors.forename: Masafumi
authors.initials: M
authors.lastname: Abe
authors.forename: Yukio
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002465:Cell Movement; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D008198:Lymph Nodes / Q000166:cytology*; D008199:Lymphadenitis / Q000209:etiology; D008297:Male; D018183:Transplantation Chimera; D014184:Transplantation, Homologous