title: [Peritonectomy and chemohyperthermia in the treatment of peritoneal carcinomatosis: learning curve].
abstract: A prospective study has been carried on 37 patients affected by peritoneal carcinomatosis from various primary. Patients have been treated by cytoreductive surgery and intraoperative hyperthermic chemoperfusion. CC 0-1 has been achieved in 81%. The temperature distribution study showed a "barrier effect" with no statistically significant correlation to the survival. Major morbidity and mortality was respectively 37.8% and 16.2%. Two-yr overall survival was 49.1% for all series. Morbidity was significantly directly correlated to the duration of the surgical treatment. A learning curve of 19 months have been observed, after that only one death out 21 procedures has been recorded. Peritoneal carcinomatosis patients, that are submitted to integrated treatment, need a peculiar management that is not comparable to any other in the oncological setting and that requires specific competence.
authors.affiliation: Azienda Ospedaliera San Camillo Forlanini, UOC di Chirurgia Generale Oncologica, Roma.
authors.forename: F
authors.initials: F
authors.lastname: Cavaliere
authors.forename: M
authors.initials: M
authors.lastname: Valle
authors.forename: B
authors.initials: B
authors.lastname: De Rosa
authors.forename: O
authors.initials: O
authors.lastname: Federici
authors.forename: D
authors.initials: D
authors.lastname: Giannarelli
authors.forename: A
authors.initials: A
authors.lastname: Garofalo
mesh_terms: D002277:Carcinoma / Q000628:therapy*; D010478:Chemotherapy, Cancer, Regional Perfusion; D006801:Humans; D006979:Hyperthermia, Induced; D010534:Peritoneal Neoplasms / Q000628:therapy*; D010537:Peritoneum / Q000601:surgery*; D011446:Prospective Studies