title: Low socioeconomic status and disability in old age: evidence from the InChianti study for the mediating role of physiological impairments.
abstract: BACKGROUND
  Low socioeconomic status (SES) has been associated with increased risk of disability in later life. The purpose of this study was to determine if SES has an impact on mobility functioning and to explore which physiological impairments are also associated with SES and may explain its relationship with mobility.
  
  
  METHODS
  The study sample consisted of 1025 individuals aged 65 years or older residing in the Chianti area (Italy). Number of years of education was used as an indicator of SES. Mobility functioning was assessed using gait speed (400 m) and the Short Physical Performance Battery (SPPB). Mobility-related physiological impairments were assessed with tests of executive functioning, nerve conduction velocity, muscle power, hip-ankle range of motion, Ankle-Brachial Index, and visual acuity. Linear regression models were used to study the association between number of years of education and mobility and to estimate the contribution of each of the selected physiological impairments to this association.
  
  
  RESULTS
  Adjusting for age and sex, slower gait speed (1.16 vs 1.26 m/s, p <.0001) and lower SPPB scores (9.55 vs 10.11, p =.006) were seen in persons with < or =5 years of total education compared with those persons with >5 years of total education. Leg power and executive function decreased the strength of the association between educational level and gait speed by more than 15%. Controlling for all selected impairments (full model) decreased the education-gait speed association by 49%. Low education continued to be significantly associated with gait speed (p <.01). Adjusting for all physiological impairments substantially reduced the low education-SPPB score association by 100%, and this association was no longer significant.
  
  
  CONCLUSIONS
  Low SES is related to multiple physiological impairments, which explain a large amount of the association between education and gait limitations. Further work must be done to understand the mechanisms whereby low SES translates into the impairments that play an important role in mobility.
authors.affiliation: Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C-309, Bethesda, MD 20892-9205, USA. coppina@mail.nih.gov
authors.forename: Antonia K
authors.initials: AK
authors.lastname: Coppin
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Fulvio
authors.initials: F
authors.lastname: Lauretani
authors.forename: Caroline
authors.initials: C
authors.lastname: Phillips
authors.forename: Miran
authors.initials: M
authors.lastname: Chang
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000453:epidemiology*; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D009140:Musculoskeletal Diseases / Q000453:epidemiology*; D012959:Socioeconomic Factors; D014786:Vision Disorders / Q000453:epidemiology*