JAK/STAT signalling: STAT cannot play with Ken and Barbie.
Transcriptional responses to the activation of a signalling pathway are cell-specific. New data show that the sequence-specific transcriptional repressors of the KEN/BCL-6 family play an important role in the selection of STAT targets in vertebrates and invertebrates, indicating that all STAT proteins may share this ancestral mechanism.
Hombría
James Castelli-Gair
JC
Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/CSIC, Sevilla, Spain. jcashom@upo.es
Sotillos
Sol
S
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D053613:Janus Kinase 1 / Q000378:metabolism*; D008954:Models, Biological; D012097:Repressor Proteins / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C508384:Ken protein, Drosophila; D012097:Repressor Proteins; D050791:STAT Transcription Factors; D053613:Janus Kinase 1