title: [Value of new prostate cancer markers: alpha methylacyl CoA racemase (P504S) and p63].
abstract: The diagnosis of prostate cancer is based on histological examination of prostatic biopsies using histological criteria identified on standard stains. In certain lesions mimicking prostate cancer, the pathologist must perform immunohistochemical studies looking for loss of basal cells and antibodies directed against cytokeratin CK 903 (34bE12) or CK5/6, which sometimes give inconclusive results leading to a diagnosis of suspicious site. The discovery of overexpression of alpha-méthylacyl CoA racemase in prostate cancer using a microarray technique has allowed the development and marketing of an antibody (P504S /AMACR) which, in combination with a new basal cell marker (p63), is a very valuable tool for the pathologist in the management of suspicious sites and cancers less than 1 mm in diameter detected on prostatic biopsies.
authors.affiliation: Service d'Anatomie et Cytologie Pathologiques, Hôpital Saint Joseph, Paris, France. vmolinie@hopital-saint-joseph.org
authors.forename: Vincent
authors.initials: V
authors.lastname: Molinié
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Hervé
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Lugagne
authors.forename: Laurent
authors.initials: L
authors.lastname: Yonneau
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ellard
authors.forename: Thierry
authors.initials: T
authors.lastname: Lebret
authors.forename: Henry
authors.initials: H
authors.lastname: Botto
mesh_terms: D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology*; D019998:Racemases and Epimerases / Q000032:analysis*
chemical_list: C081876:CKAP4 protein, human; D008565:Membrane Proteins; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase