[Aseptic meningitis during Sweet syndrome].
BACKGROUND
Sweet syndrome is a neutrophilic skin disease that can involve extracutaneous signs. Here we describe a case of aseptic meningitis, a rare potential extracutaneous sign of Sweet syndrome.


METHODS
A 42-year-old man was hospitalized for non-pruritic maculoerythematous skin lesions of the legs and back with subsequent myalgia. A histology specimen taken from a skin lesion revealed an acute neutrophilic disease consistent with Sweet syndrome. Marked inflammation and cholestasis were observed. Systemic corticosteroid therapy was given and resulted in good clinical and laboratory response. Two weeks later, in a setting of gradual dosage reduction, the patient was hospitalized for intense headaches associated with meningeal irritation in an inflammatory context. Liver function tests were again abnormal. We concluded on a diagnosis of Sweet syndrome complicated by aseptic meningitis and hepatic sites. Investigation for underlying disease, particularly digestive or hematologic, was negative. A favorable outcome was achieved following administration of higher doses of systemic corticosteroids.


CONCLUSIONS
Aseptic meningitis constitutes an extracutaneous localization of Sweet syndrome. A multidisciplinary approach and exclusion of infectious origin are required in order to institute systemic corticosteroid therapy.
Balass
S
S
Service de Dermatologie, Centre Hospitalier Saint-Philibert, Université Catholique de Lille.
Duparc
A
A
Zaïd
S
S
Bularca
S
S
Modiano
Ph
P
D000208:Acute Disease; D000328:Adult; D002779:Cholestasis; D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation; D008297:Male; D008582:Meningitis, Aseptic / Q000209:etiology* / Q000473:pathology; D016463:Sweet Syndrome / Q000150:complications* / Q000175:diagnosis