Oral lesions as an initial manifestation of dermatomyositis with occult malignancy.
Dermatomyositis (DM) is an inflammatory disease of skeletal muscle with characteristic cutaneous features. Oral manifestations of DM have been very rarely described. This case describes a patient in whom the oral lesions were among the initial manifestations of DM. The lesions were very painful and the most distressing component of the disease in this patient. High dose systemic steroids were required to control the lesions. Investigations for an occult malignancy in this patient resulted in the identification of a non-Hodgkin's lymphoma in her right kidney. Commencement of chemotherapy rapidly resulted in complete resolution of her oral and skin lesions.
Healy
Claire M
CM
Dublin Dental School and Hospital, Trinity College, Dublin, Ireland. claire.healy@dental.tcd.ie
Tobin
Anne-Marie
AM
Kirby
Brian
B
Flint
Stephen R
SR
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003882:Dermatomyositis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005891:Gingivitis / Q000188:drug therapy / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy; D015448:Leukemia, B-Cell / Q000150:complications* / Q000188:drug therapy; D009061:Mouth Mucosa / Q000473:pathology; D019226:Oral Ulcer / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D005938:Glucocorticoids; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone