Topical tacrolimus in Hailey-Hailey disease.
Hailey-Hailey disease, or familial benign chronic pemphigus, is a rare relapsing-remitting autosomal-dominant epidermal blistering disease. It preferentially affects females and is characterized by recurrent vesicles and erosions in the intertriginous areas. There are several topical corticosteroid therapeutic options, which are often limited in their use by their secondary effects and localization of the lesions. We report a case of a 60-year-old woman with Hailey-Hailey disease involving axillary, groin, cervical, antecubital, inframammary and abdominal folds. She was treated with 0.1% tacrolimus ointment, applied twice daily, with clinical improvement in 2 weeks and total remission in 4 weeks. She remains asymptomatic after a 10-month follow-up period.
Rocha Paris
F
F
Dermatology Department, Desterro Hospital, Lisbon, Portugal.
Fidalgo
A
A
Baptista
J
J
Caldas
L Lopes
LL
Ferreira
A
A
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000627:therapeutic use; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000188:drug therapy* / Q000503:physiopathology; D016559:Tacrolimus / Q000008:administration & dosage* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D017291:Clarithromycin; D016559:Tacrolimus