title: [Scientific progress and new biological weapons].
abstract: The biological weapons are different from conventional weapons, because living germs hold an extraordinary and predictable potential for multiplication, propagation and genetic variation during their dissemination in a susceptible population. Only natural pathogens (1rst generation weapons) have been used in the past (smallpox virus, plague, anthrax, toxins...). However, new threats are emerging, due to the rapid progress of scientific knowledge and its exponential worldwide diffusion. It is possible to synthesize microorganisms from in silico sequences widely diffused on Internet (poliovirus, influenza...), thus resulting in the accessibility of very dangerous virus confined today in high-security laboratories (virus Ebola...). It is possible also to "improve" pathogens by genetic manipulations, becoming more resistant or virulent (2nd generation weapons). Finally, one can now create de novo new pathogens by molecular breeding (DNA shuffling), potentially highly dangerous for naive populations (3rd generation weapons). Making biological weapons does not require too much technological resources and appears accessible to terrorists, due to low cost and easy use. Although the destructive consequences are difficult to predict, the psychological and social damages should be considerable, because of the highly emotional burden in the population associated to the transgression by man of a taboo of life.
authors.affiliation: Service de microbiologie, Hôpital Necker- Enfants-malades, 149, rue de Sèvres, 75015 Paris, France. berche@necker.fr
authors.forename: Patrick
authors.initials: P
authors.lastname: Berche
mesh_terms: D001694:Biological Warfare / Q000639:trends*; D023482:Bioterrorism / Q000639:trends; D004274:DNA, Recombinant / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate; D033181:Information Dissemination / Q000941:ethics; D030781:Organisms, Genetically Modified / Q000235:genetics; D011995:Recombination, Genetic; D014774:Virulence / Q000235:genetics
chemical_list: D004274:DNA, Recombinant