title: Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance.
abstract: BACKGROUND
  We evaluated whether contrast-enhanced multidetector computed tomography (CE-MDCT) might characterize myocardial infarct (MI) with patterns similar to those obtained by contrast-enhanced magnetic resonance (CE-MR) and studied the underlying mechanisms.
  
  
  RESULTS
  In vivo infarct characterization by CE-MDCT was shown to be feasible between 4 and 20 minutes after contrast injection in 7 pigs with MI. Subsequently, in 16 patients with acute MI and 21 patients with chronic MI, contrast patterns by CE-MDCT were related to CE-MR. Eighteen patients had hypoenhanced regions on early CE-MDCT images at the time of coronary imaging, and 34 patients had hyperenhanced regions on images acquired 10 minutes later. On a segmental basis, there was moderately good concordance of early hypoenhanced regions (92%, kappa=0.54, P<0.001) and late hyperenhanced regions (82%, kappa=0.61, P<0.001) between CE-MDCT and CE-MR. Absolute sizes of early hypoenhanced (6+/-16 versus 7+/-16 g, P=0.25) and late hyperenhanced (36+/-34 versus 31+/-40 g, P=0.14) regions were similar on CE-MDCT and CE-MR and were highly correlated (r=0.93, P<0.001 and r=0.89, P<0.001 respectively). In 8 retrogradely perfused infarcted rabbit hearts, contrast kinetics of iomeprol were similar to gadodiamide, ie, slow wash in (8.7+/-6.7 versus 1.2+/-0.3 minutes, P<0.001) in infarct core and slow washout (20+/-12 versus 2.5+/-0.5 minutes, P<0.001) in both infarct core and rim compared with the remote region.
  
  
  CONCLUSIONS
  Because iodated contrast agents have similar kinetics in infarcted and noninfarcted myocardium as gadolinium DPTA, CE-MDCT can characterize acute and chronic MI with contrast patterns similar to CE-MR. CE-MDCT may thus provide important information on infarct size and viability at the time of noninvasive coronary imaging.
authors.affiliation: Department of Cardiology, Cliniques Universitaires St. Luc UCL, Université Catholique de Louvain, Brussels, Belgium. Bernhard.gerber@clin.ucl.ac.be
authors.forename: Bernhard L
authors.initials: BL
authors.lastname: Gerber
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Belge
authors.forename: Gabin J
authors.initials: GJ
authors.lastname: Legros
authors.forename: Pascal
authors.initials: P
authors.lastname: Lim
authors.forename: Alain
authors.initials: A
authors.lastname: Poncelet
authors.forename: Agnès
authors.initials: A
authors.lastname: Pasquet
authors.forename: Giovanna
authors.initials: G
authors.lastname: Gisellu
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Coche
authors.forename: Jean-Louis J
authors.initials: JL
authors.lastname: Vanoverschelde
mesh_terms: D000208:Acute Disease; D000368:Aged; D000818:Animals; D002908:Chronic Disease; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007479:Iopamidol / Q000031:analogs & derivatives; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology; D011817:Rabbits; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol; D019786:Gadolinium DTPA