title: New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica.
abstract: A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
authors.affiliation: Chemical Department, Lomonosov State University, Leninskie Gory, 119992 Moscow, Russian Federation.
authors.forename: S M
authors.initials: SM
authors.lastname: Staroverov
authors.forename: M A
authors.initials: MA
authors.lastname: Kuznetsov
authors.forename: P N
authors.initials: PN
authors.lastname: Nesterenko
authors.forename: G G
authors.initials: GG
authors.lastname: Vasiarov
authors.forename: G S
authors.initials: GS
authors.lastname: Katrukha
authors.forename: G B
authors.initials: GB
authors.lastname: Fedorova
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006020:Glycopeptides / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C053759:eremomycin; D012822:Silicon Dioxide