title: The lethality of Euphorbia conspicua to adults of Biomphalaria glabrata, cercaria of Schistosoma mansoni and larvae of Artemia salina.
abstract: Leaf extracts of Euphorbia conspicua (Euphorbiaceae), together with the latex and fractions derived therefrom, were evaluated for their molluscicidal and cercaricidal activities and their toxicities to brine shrimps. Whilst the leaf extracts were inactive against Biomphalaria glabrata, the latex, its triterpenic fraction and irritant fractions I and II exhibited high activities against adult snails with LC90 values of 4.87, 10.55, 0.64 and 0.10 microg/mL, respectively. The latex and its derived fractions were considered lethal to the cercaria of Schistosoma mansoni at concentrations of 100 microg/mL. The toxicities of the latex and the irritant fractions, but not of the triterpenic fraction, against Artemia salina were high with LC50 values < 10 microg/mL. The possible application of the latex of E. conspicua as an alternative natural molluscicide is considered.
authors.affiliation: Chemistry Department, Federal University of Alagoas, 57092-970, Maceió-AL, Brazil.
authors.forename: Aldenir F
authors.initials: AF
authors.lastname: dos Santos
authors.forename: Denise P L
authors.initials: DP
authors.lastname: de Azevedo
authors.forename: Rosalina da C
authors.initials: Rda C
authors.lastname: dos Santos Mata
authors.forename: Dina I M Dinis
authors.initials: DI
authors.lastname: de Mendonça
authors.forename: Antônio E Goulart
authors.initials: AE
authors.lastname: Sant'Ana
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects*; D001700:Biomphalaria / Q000187:drug effects*; D028481:Euphorbia / Q000737:chemistry*; D007814:Larva / Q000187:drug effects; D007840:Latex / Q000737:chemistry / Q000633:toxicity; D007928:Lethal Dose 50; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D012550:Schistosoma mansoni / Q000187:drug effects*
chemical_list: D007840:Latex; D010936:Plant Extracts