title: Melengestrol acetate in experimental diets as an effective alternative to induce a decline in egg production and reversible regression of the reproductive tract in laying hens. I. Determining an effective concentration of melengestrol acetate.
abstract: Induced molting increases egg quality and egg production and extends the productive life of hens. Molting is accomplished by feed withdrawal, which has been criticized for not addressing hen well-being, and current alternatives have resulted in poor postmolt performance and inadequate well-being. Molting leads to regression of follicles on the ovary and causes loss of steroidogenic support for the oviduct, leading to cessation of lay. Melengestrol acetate (MGA), an orally active progestin, may decrease support for the ovary, resulting in loss of support for the oviduct, while hens are fed a balanced diet. In this experiment, a dose response study, Hy-Line W-36 hens were fed 0, 0.1, 1, 4, or 8 mg of MGA per hen/d in a balanced diet for 28 d and then returned to a normal diet. Four birds on d 0 and 4 birds per treatment on d 1, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, and 44 were euthanized. The weight of the ovary with follicles, magnum, shell gland, and oviduct were determined. A decrease in egg production was observed in those groups receiving 4 and 8 mg of MGA, until removal of MGA from the diet. After d 28, egg production increased to the production level of hens fed 0, 0.1, or 1 mg of MGA. The weight of the ovary with follicles, oviduct, magnum, and shell gland were unchanged throughout in groups fed 0, 0.1, or 1 mg of MGA. However, groups fed 4 or 8 mg of MGA exhibited a decrease (P < 0.05) in the weight of the ovary with follicles, oviduct, magnum, and shell gland until d 28. Recrudescence of the large yellow follicles as well as rejuvenation of the oviduct and its components, the magnum and shell gland, in the 4 and 8 mg MGA groups occurred by d 44. Melengestrol acetate, fed to hens on a balanced layer diet, caused reversible regression of follicles and, therefore, removal and return of support for the oviduct.
authors.affiliation: Division of Animal and Veterinary Science, Davis College of Agriculture, Forestry and Consumer Sciences, West Virginia University Morgantown, West Virginia 26506, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Koch
authors.forename: J S
authors.initials: JS
authors.lastname: Moritz
authors.forename: D C
authors.initials: DC
authors.lastname: Lay
authors.forename: M E
authors.initials: ME
authors.lastname: Wilson
mesh_terms: D000375:Aging; D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000502:physiology*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D005938:Glucocorticoids / Q000494:pharmacology; D008552:Melengestrol Acetate / Q000008:administration & dosage* / Q000494:pharmacology*; D010058:Oviposition / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D008552:Melengestrol Acetate