The cellular basis of a corollary discharge.
How do animals discriminate self-generated from external stimuli during behavior and prevent desensitization of their sensory pathways? A fundamental concept in neuroscience states that neural signals, termed corollary discharges or efference copies, are forwarded from motor to sensory areas. Neurons mediating these signals have proved difficult to identify. We show that a single, multisegmental interneuron is responsible for the pre- and postsynaptic inhibition of auditory neurons in singing crickets (Gryllus bimaculatus). Therefore, this neuron represents a corollary discharge interneuron that provides a neuronal basis for the central control of sensory responses.
Poulet
James F A
JF
Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. james.poulet@epfl.ch
Hedwig
Berthold
B
D000161:Acoustic Stimulation; D000200:Action Potentials; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D003712:Dendrites / Q000502:physiology; D005426:Flight, Animal; D017952:Ganglia, Invertebrate / Q000502:physiology*; D006135:Gryllidae / Q000502:physiology*; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009433:Neural Inhibition; D009475:Neurons, Afferent / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D014828:Vocalization, Animal; D014921:Wings, Animal / Q000502:physiology