Identification of genes involved in alcohol consumption and cigarettes smoking.
We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis using the Collaborative Study on the Genetics of Alcoholism data. We analyzed 115 extended non-Hispanic White families and tested for linkage using two phenotypes: the maximum number of drinks in a 24-hour period and the number of packs smoked per day for one year. Our results showed that the linkage signal increased using single-nucleotide polymorphisms compared with microsatellite markers and that the screening test gave similar results to that of the bivariate analysis, suggesting its potential use in reducing overall analysis time.
de Andrade
Mariza
M
Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA. mandrade@mayo.edu
Olswold
Curtis L
CL
Slusser
Joshua P
JP
Tordsen
Larry A
LA
Atkinson
Elizabeth J
EJ
Rabe
Kari G
KG
Slager
Susan L
SL
D000428:Alcohol Drinking / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012907:Smoking / Q000235:genetics*