Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.
Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity.
Levine
Arnold J
AJ
The Institute for Advanced Study, Princeton, New Jersey 08540, USA. alevine@ias.edu
Feng
Zhaohui
Z
Mak
Tak W
TW
You
Han
H
Jin
Shengkan
S
D000818:Animals; D004789:Enzyme Activation; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism; D051058:Oncogene Protein v-akt / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D051858:Forkhead Transcription Factors; D009097:Multienzyme Complexes; D016159:Tumor Suppressor Protein p53; D007334:Insulin-Like Growth Factor I; D011494:Protein Kinases; C546842:MTOR protein, human; D051058:Oncogene Protein v-akt; D058570:TOR Serine-Threonine Kinases