title: Cerebral blood flow in mean cerebral artery low density areas is not always ischemic in patients with aneurysmal subarachnoid hemorrhage--relationship with neurological outcome.
abstract: Aneurysmal subarachnoid hemorrhage (SAH) can be complicated by reduction of regional cerebral blood flow (rCBF) from large conductance vessels leading to focal edema appearing as an area of hypoattenuation on CT. In this study we included 29 patients with SAH due to aneurysmal rupture, having 36 CT low density areas within the middle cerebral artery territory in whom a total of 56 Xenon-CT (Xe-CT) studies were performed. Collectively, we evaluated 70 hypoattenuated areas. rCBF levels were measured in two different regions of interest drawn manually on the CT scan, one in the low density area and the other in a corresponding contralateral area of normal-appearing brain tissue. In the low density area (22.6 +/- 22.7 ml/100 gr/min) rCBF levels were significantly lower than in the contralateral area (32.8 +/- 17.1 7 ml/100 gr/min) (p = 0.0007). In the injured areas deep ischemia (CBF < 6 ml/ 100 g/min) was present in only 25.7% of Xe-CT studies, suggesting that hypodense areas are not always ischemic, whereas in 43.7% of the lesions/Xe-CT studies we found hyperemic values. Patients with a better outcome had hyperemic lesions, suggesting brain tissue recovery in injured areas.
authors.affiliation: Neurorianimazione, Ospedale M. Bufalini, Cesena, Italy. achiere@ausl-cesena.emr.it
authors.forename: A
authors.initials: A
authors.lastname: Chieregato
authors.forename: F
authors.initials: F
authors.lastname: Tagliaferri
authors.forename: A
authors.initials: A
authors.lastname: Tanfani
authors.forename: F
authors.initials: F
authors.lastname: Cocciolo
authors.forename: W
authors.initials: W
authors.lastname: Benedettini
authors.forename: C
authors.initials: C
authors.lastname: Compagnone
authors.forename: M
authors.initials: M
authors.lastname: Ravaldini
authors.forename: R
authors.initials: R
authors.lastname: Pascarella
authors.forename: R
authors.initials: R
authors.lastname: Battaglia
authors.forename: M
authors.initials: M
authors.lastname: Frattarelli
authors.forename: L
authors.initials: L
authors.lastname: Targa
authors.forename: E
authors.initials: E
authors.lastname: Fainardi
mesh_terms: D015502:Absorptiometry, Photon / Q000706:statistics & numerical data; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000401:mortality*; D002539:Cerebral Arterial Diseases / Q000000981:diagnostic imaging* / Q000401:mortality*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013223:Statistics as Topic; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging* / Q000401:mortality*