title: Tumor suppressors: control of signaling by endocytosis.
abstract: Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.
authors.affiliation: Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, Geb. 14.80, 40225 Düsseldorf, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Giebel
authors.forename: Andreas
authors.initials: A
authors.lastname: Wodarz
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D016764:Cell Polarity / Q000502:physiology*; D049109:Cell Proliferation; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D004705:Endocytosis / Q000235:genetics / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D004847:Epithelial Cells / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D029721:Drosophila Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; C511665:Vps25 protein, Drosophila; C064360:crb protein, Drosophila