title: [Esophageal atresia and chromosomal abnormalities in a Mexican children population: descriptive analysis].
abstract: BACKGROUND
  Chromosome alterations are associated with esophageal atresia (EA) in up to 11% of the cases. The morbidity and mortality index of this population is different from other EA patients. The present study was aimed to determine the characteristics of this association in a Mexican infant patient population.
  
  
  METHODS
  Observational, descriptive, retrospective, transversal assay including patients with AE and chromosome alterations over a 31-year period. Gestational age, admittance age, sex, type of atresia, chromosome alteration, additional malformations, treatment, evolution and death cause, were registered.
  
  
  RESULTS
  Seventeen patients (4.61%) out of 368 with EA were included. Chromosome 21 trisomy was detected in 12 children and 5 with 18 trisomy. One to 3 additional malformations were found in 16 patients. Fifteen children were subjected to surgical procedures for EA, and 6 for associated malformations. Fourteen children died in a 140-day follow-up period.
  
  
  CONCLUSIONS
  Coexistence between AE, trisomys and major malformations was characterized by multifactorial complications which determined adverse evolution in the short term.
authors.affiliation: Laboratorio de Cirugía Experimental, Instituto Nacional de Pediatría, México.
authors.forename: J F
authors.initials: JF
authors.lastname: González-Zamora
authors.forename: F
authors.initials: F
authors.lastname: Villegas-Alvarez
mesh_terms: D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D004933:Esophageal Atresia / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008800:Mexico; D014314:Trisomy