Effect of liniment levamisole on cellular immune functions of patients with chronic hepatitis B.
OBJECTIVE
To explore the effects of liniment levamisole on cellular immune functions of patients with chronic hepatitis B.


METHODS
The levels of T lymphocyte subsets and mIL-2R in peripheral blood mononuclear cells (PBMCs) were measured by biotin-streptavidin (BSA) technique in patients with chronic hepatitis B before and after the treatment with liniment levamisole.


RESULTS
After one course of treatment with liniment levamisole, the levels of CD3(+), CD4(+), and the ratio of CD4(+)/CD8(+) increased as compared to those before the treatment but the level of CD8(+) decreased. The total expression level of mIL-2R in PBMCs increased before and after the treatment with liniment levamisole.


CONCLUSIONS
Liniment levamisole may reinforce cellular immune functions of patients with chronic hepatitis B.
Wang
Ke-Xia
KX
Department of Pathogenic Biology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui Province, China. cpli@aust.edu.cn
Zhang
Li-Hua
LH
Peng
Jiang-Long
JL
Liang
Yong
Y
Wang
Xue-Feng
XF
Zhi
Hui
H
Wang
Xiang-Xia
XX
Geng
Huan-Xiong
HX
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000328:Adult; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007978:Levamisole / Q000008:administration & dosage*; D008038:Liniments; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D008038:Liniments; D007978:Levamisole