title: NnrA is required for full virulence and regulates several Brucella melitensis denitrification genes.
abstract: We identified two regulators of denitrification genes in Brucella melitensis 16M: NarR, which regulates the nitrate reductase (nar) operon, and NnrA, which is involved in the expression of the last three reductases of the denitrification pathway (nirK, norB, and nosZ). NnrA is required for virulence in mice and for intracellular resistance to nitric oxide.
authors.affiliation: Unité de Recherche en Biologie Moléculaire (URBM), University of Namur (FUNDP), 61 rue de Bruxelles, B-5000 Namur, Belgium.
authors.forename: Valérie
authors.initials: V
authors.lastname: Haine
authors.forename: Marie
authors.initials: M
authors.lastname: Dozot
authors.forename: Jacques
authors.initials: J
authors.lastname: Dornand
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Letesson
authors.forename: Xavier
authors.initials: X
authors.lastname: De Bolle
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D017347:Brucella melitensis / Q000235:genetics* / Q000472:pathogenicity; D002006:Brucellosis / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D051379:Mice; D050901:Nitrate Reductase / Q000235:genetics*; D009569:Nitric Oxide; D009876:Operon; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D009569:Nitric Oxide; D050901:Nitrate Reductase