The role of growth hormone in neural development.
Growth hormone (GH) is integrally involved in the development of the central nervous system (CNS), as well as during its recovery from injury, two processes that share many similarities and may influence CNS functionality. This review discusses some of the most recent findings in the field and, in particular, the ontogeny, distribution, regulation and putative functions of GH and its receptor within the CNS, particularly during development. The relative roles of peripheral GH, acting in part through insulin-like growth factor-I, and of the autocrine/paracrine GH system within the brain are considered. The potential role of GH as a therapeutic agent to influence brain development and function is discussed.
Scheepens
Arjan
A
Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand. a.scheepens@auckland.ac.nz
Möderscheim
Tanja A E
TA
Gluckman
Peter D
PD
D000818:Animals; D019898:Autocrine Communication / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000196:embryology*; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D038081:Organogenesis / Q000187:drug effects / Q000502:physiology*; D019899:Paracrine Communication / Q000187:drug effects / Q000502:physiology; D011986:Receptors, Somatotropin / Q000378:metabolism*
D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone