title: Changes of the biochemical markers of bone turnover and periprosthetic bone remodeling after cemented hip arthroplasty.
abstract: Do periprosthetic bone loss and postoperative levels of the biochemical markers of bone turnover correlate? The femoral bone mineral density of 53 patients was measured by dual-energy x-ray absorptiometry 1 week and 2, 4, 6, and 12 months after cemented total hip arthroplasty (THA). Biochemical markers of bone turnover were assayed preoperatively and 3, 8, 16, and 24 weeks post-THA. Greatest bone loss was detected in the calcar region (region of interest 7), on average, 16% after 1 year. A marker of bone resorption, C-terminal telopeptides of type I collagen, increased 21% 3 weeks after THA. A significant correlation between periprosthetic bone loss in region of interest 7 after 1 year and type I collagen at 3 weeks was seen (r = -0.42, P = .003). Data suggest that periprosthetic bone loss is induced by an early postoperative high activity of osteoclasts. Counteracting this osteoclast activity with a limited and timely postoperative antiresorptive treatment may be concluded for clinical application.
authors.affiliation: Department of Orthopaedic Surgery, University Hospital Frankfurt (Orthopädische Universitätsklinik Frankfurt-Stiftung Friedrichsheim), 60528 Frankfurt/M., Germany.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Arabmotlagh
authors.forename: Robert
authors.initials: R
authors.lastname: Sabljic
authors.forename: Markus
authors.initials: M
authors.lastname: Rittmeister
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000097:blood*; D015519:Bone Density; D016723:Bone Remodeling; D002484:Cementation; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D024042:Collagen Type I