Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects.
Data has accumulated indicating an inverse relation between central serotonergic (5-HT) neurotransmission and blood pressure in hypertensive rats and in healthy individuals. The present study aimed to elucidate whether an inverse relation exists between systolic (SBP) and diastolic (DBP) blood pressure levels and central 5-HT neurotransmission also in a group of alcohol-dependent individuals. Central 5-HT neurotransmission was assessed by using the maximum prolactin (PRL) responses to the 5-HT probe DL-fenfluramine (DL-FEN; 60 mg po) in 17 alcohol-dependent male subjects investigated during a period of on-going alcohol intake. BP was measured immediately before all time points for blood sampling, and readings before DL-FEN administration were used as the subjects resting BP. Results showed that there were inverse correlations between the maximum PRL responses to DL-FEN and the SBP levels (r = -0.57, p < 0.002) and with the DBP levels (r = -0.52, p < 0.05), respectively. The present study suggests the existence of an association between central 5-HT neurotransmission and blood pressure regulation also in alcohol-dependent individuals.
Balldin
J
J
Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska Academy at Göteborg University, Sahlgrenska University Hospital/Mölndal, Göteborg, Sweden.
Andersson
M
M
Berggren
U
U
Engel
J
J
Eriksson
M
M
Fahlke
C
C
D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D018490:Serotonin Agents; D005277:Fenfluramine; D012701:Serotonin; D011388:Prolactin