title: Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development.
abstract: Interaction of Eph receptor tyrosine kinases with their membrane bound ephrin ligands initiates bidirectional signaling events that regulate cell migratory and adhesive behavior. Whole-mount in situ hybridization revealed overlapping expression of the Epha1 receptor and its high-affinity ligands ephrin A1 (Efna1) and ephrin A3 (Efna3) in the primitive streak and the posterior paraxial mesoderm during early mouse development. These results show complex and dynamic expression for all three genes with expression domains that are successively complementary, overlapping, and divergent.
authors.affiliation: Leukaemia Foundation Research Unit, Queensland Institute of Medical Research, Herston, Australia. Shannon.Duffy@qimr.edu.au
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Duffy
authors.forename: Kirsten A
authors.initials: KA
authors.lastname: Steiner
authors.forename: Patrick P L
authors.initials: PP
authors.lastname: Tam
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Boyd
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D036382:Ephrin-A1 / Q000235:genetics* / Q000378:metabolism; D036384:Ephrin-A3 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005775:Gastrula / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008024:Ligands; D008648:Mesoderm / Q000378:metabolism*; D051379:Mice; D038081:Organogenesis; D011247:Pregnancy; D036082:Receptor, EphA1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D036382:Ephrin-A1; D036384:Ephrin-A3; D008024:Ligands; D036082:Receptor, EphA1