Cooperative binding and self-assembling behavior of cationic low molecular-weight dendrons with RNA molecules.
Tri(ethylene glycol) derived, low molecular-weight dendrons with various amine end groups were synthesized and characterized for their properties of binding and self-assembling with RNA using the Candida ribozyme as a model RNA molecule. These dendritic compounds form stable complexes and well-defined nanoscale particles with RNA molecules via electrostatic interactions and self-assembly process, while leaving the other terminal of the tri(ethylene glycol) chain accessible for targeting. This suggests that dendrimers of this type hold great promise for specific RNA targeting and RNA delivery.
Zhou
Jiehua
J
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.
Wu
Jiangyu
J
Liu
Xiaoxuan
X
Qu
Fanqi
F
Xiao
Mu
M
Zhang
Yi
Y
Charles
Laurence
L
Zhang
Cheng-Cai
CC
Peng
Ling
L
D002175:Candida / Q000201:enzymology; D002412:Cations / Q000737:chemistry; D002942:Circular Dichroism; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D008970:Molecular Weight; D049329:Nanostructures; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
D002412:Cations; D050091:Dendrimers; C028914:triethylene glycol; D011092:Polyethylene Glycols; D012313:RNA; D008274:Magnesium