Highly regio- and stereoselective synthesis of tetrasubstituted olefins by the three-component tandem reaction of allylzinc bromide, acetylenic sulfone, and halohydrocarbon.
[reation: see text]. Tetrasubstituted olefins containing a 1,4-diene structural unit can be regio- and stereoselectively constructed in one pot by the allylzincation of acetylenic sulfones, followed by Negishi cross-coupling with halohydrocarbons in the presence of catalytic Ni(PPh3)2Cl2.
Xie
Meihua
M
Anhui Key Laboratory of Functional Molecular Solids, Institute of Organic Chemistry, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China. gxmeihua@yahoo.com.cn
Wang
Jialiang
J
Gu
Xiaoxia
X
Sun
Ying
Y
Wang
Shaowu
S