title: [Diffuse large B-cell lymphoma expressing surface immunoglobulin heavy chain (Ig alpha) and lacking light chains].
abstract: A 59-year-old woman with goiter complained of nausea, vomiting and weight loss in April 2000. She underwent an endoscopic examination and was admitted to our hospital because gastric biopsy specimens revealed that she had diffuse large B-cell lymphoma. A thyroid biopsy also detected the diffuse infiltration of lymphoma cells, which were positive for CD19, CD20, CD38 and HLA-DR. Although the cells expressed surface immunoglobulin a chain, they lacked expressions of the kappa and lambda light chains. Chromosomal analysis of the thyroid cells showed 47, XX, t(2 ; 3)(q31 ; q13), + 3, t(8 ; 22)(q24 ; q11). After five courses of biweekly CHOP chemotherapy, she received autologous peripheral blood stem cell transplantation in October 2000. Currently, she has maintained complete remission for more than 4 years.
authors.affiliation: Department of Hematology, Juntendo University School of Medicine.
authors.forename: Miki
authors.initials: M
authors.lastname: Ando
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Isobe
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Jun
authors.initials: J
authors.lastname: Ando
authors.forename: Kazuo
authors.initials: K
authors.lastname: Oshimi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D007137:Immunoglobulin alpha-Chains; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D007147:Immunoglobulin Light Chains; D007137:Immunoglobulin alpha-Chains; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone