title: The radiation sensitivity of human chromosomes 2, 8 and 14 in peripheral blood lymphocytes of seven donors.
abstract: OBJECTIVE
  To investigate if deviations from DNA-proportional distribution of radiation-induced chromosomal aberrations are individually variable.
  
  
  METHODS
  Peripheral blood lymphocytes were collected from seven healthy donors and exposed to different doses of gamma rays. Chromosomes 2, 8 and 14 were painted in different colors and aberrations scored with the help of an image-analysis system.
  
  
  RESULTS
  Chromosome 2 was generally less sensitive than expected on the basis of DNA-proportional distribution and the extent of inter-donor variability was minimal. A higher than expected frequency of aberrations was found in chromosome 14 of five donors, while a higher than expected frequency of aberrations was found in chromosome 8 of two donors.
  
  
  CONCLUSIONS
  Inter-donor variability may explain some of the controversies regarding the inter-chromosomal distribution of radiation-induced aberrations.
authors.affiliation: Institute of Nuclear Chemistry and Technology, Department of Radiobiology and Health Protection, Warszawa.
authors.forename: Sylwester
authors.initials: S
authors.lastname: Sommer
authors.forename: Iwona
authors.initials: I
authors.lastname: Buraczewska
authors.forename: Maria
authors.initials: M
authors.lastname: Wojewodzka
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Bouzyk
authors.forename: Irena
authors.initials: I
authors.lastname: Szumiel
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wojcik
mesh_terms: D000328:Adult; D018929:Cell Culture Techniques; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002883:Chromosomes, Human, Pair 14 / Q000528:radiation effects*; D002889:Chromosomes, Human, Pair 2 / Q000528:radiation effects*; D002898:Chromosomes, Human, Pair 8 / Q000528:radiation effects*; D004247:DNA / Q000032:analysis; D004249:DNA Damage; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
chemical_list: D004247:DNA