Synthesis and anticancer activity of thiosemicarbazones.
Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 microM.
Hu
Wei-xiao
WX
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032, PR China. huyang@mail.hz.zj.cn
Zhou
Wei
W
Xia
Chun-nian
CN
Wen
Xi
X
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002246:Carbon Disulfide / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006834:Hydrazines / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006834:Hydrazines; D013882:Thiosemicarbazones; C029424:hydrazine; D002246:Carbon Disulfide