title: Aggressive basal cell carcinoma with invasion of the parotid gland, facial nerve, and temporal bone.
abstract: Aggressive variants of basal cell carcinoma (BCC), such as infiltrating, morpheaform, and basosquamous types, are associated with invasion of underlying tissues and are often difficult to treat.1 BCCs located in embryonic fusion planes, such as the periauricular region, are thought to exhibit deep extension and, subsequently, high recurrence rates, although this theory has been challenged and remains controversial.2-4 Despite the known features of aggressive BCC, parotid gland invasion and temporal bone and facial nerve involvement are rarely reported occurrences. We describe two patients with morpheaform BCC in the periauricular region demonstrating direct invasion of the parotid gland and concomitant facial nerve involvement. These patients require complex surgical management, as highlighted in this report.
authors.affiliation: College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Farley
authors.forename: Spiros
authors.initials: S
authors.lastname: Manolidis
authors.forename: Désirée
authors.initials: D
authors.lastname: Ratner
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000601:surgery; D005154:Facial Nerve / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009423:Nervous System Neoplasms / Q000473:pathology* / Q000601:surgery; D013517:Otorhinolaryngologic Surgical Procedures; D010307:Parotid Neoplasms / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery; D013701:Temporal Bone / Q000473:pathology