title: A personalized and automated dbSNP surveillance system.
abstract: The development of high throughput techniques and large-scale studies in the biological sciences has given rise to an explosive growth in both the volume and types of data available to researchers. A surveillance system that monitors data repositories and reports changes helps manage the data overload. We developed a dbSNP surveillance system (URL: http://www.pharmgkb.org/do/serve?id=tools.surveillance.dbsnp) that performs surveillance on the dbSNP database and alerts users to new information. The system is notable because it is personalized and fully automated. Each registered user has a list of genes to follow and receives notification of new entries concerning these genes. The system integrates data from dbSNP, LocusLink, PharmGKB, and Genbank to position SNPs on reference sequences and classify SNPs into categories such as synonymous and non-synonymous SNPs. The system uses data warehousing, object model-based data integration, object-oriented programming, and a platform-neutral data access mechanism.
authors.affiliation: Department of Genetics, Stanford Medical Informatics, CA 94305-5479, USA.
authors.forename: Shuo
authors.initials: S
authors.lastname: Liu
authors.forename: Steve
authors.initials: S
authors.lastname: Lin
authors.forename: Mark
authors.initials: M
authors.lastname: Woon
authors.forename: Teri E
authors.initials: TE
authors.lastname: Klein
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
mesh_terms: D004247:DNA / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods*; D003628:Database Management Systems; D030541:Databases, Genetic; D033181:Information Dissemination / Q000379:methods; D016247:Information Storage and Retrieval / Q000379:methods*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012042:Registries; D012984:Software; D018511:Systems Integration; D014584:User-Computer Interface
chemical_list: D004247:DNA