Analysis of genes for alcoholism using two-disease-locus models.
Using model-based two-locus methods for mapping genes, we analyzed the family data from the Collaborative Study on the Genetics of Alcoholism. Microsatellite data from 143 families ascertained through having three or more individuals affected with alcohol dependence were used for this investigation. Four regions showing evidence for linkage were identified using single-locus models from previous investigations. We investigated the genetic linkage, pattern of disease inheritance, and pair-wise genetic epistasis of these loci using the TLINKAGE program for two-disease-locus analysis.
Wu
Chih-Chieh
CC
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. ccwu@mdanderson.org
Shete
Sanjay
S
D000437:Alcoholism / Q000235:genetics*; D018740:Genetic Heterogeneity; D056426:Genetic Loci / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics