title: RETRACTED: Selective targeting of checkpoint kinase 1 in tumor cells with a novel potent oncolytic adenovirus.
abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
  
  This article has been retracted at the request of the editor-in-chief. Similarities were reported between images in this article and an article in Clinical Cancer Research (Zhou et al., 2005, Clin. Cancer Res. 11, 8431-8440, https://10.1158/1078-0432.CCR-05-1085). Q.J., J.Z., X.H., G.C., Y.L., K.L., L.Z., and D.M. were all authors of the Clinical Cancer Research paper as well. These concerns were initially reported in a Pubpeer thread (https://pubpeer.com/publications/FF881782FF5AFD316D42E0C0F00766). Image analysis performed by the editorial office confirmed findings of image recycling in Figures 2A and 3B of the Molecular Therapy article. This reuse (and in part misrepresentation) of data without appropriate attribution represents a severe abuse of the scientific publishing system.
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Qinglei
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Yunping
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Kanyan
authors.initials: K
authors.lastname: Li
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhuang
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Mei
authors.initials: M
authors.lastname: Huang
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
authors.forename: Shxuan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China. Electronic address: dma@tjh.tjmu.edu.cn.
authors.forename: Ding
authors.initials: D
authors.lastname: Ma
mesh_terms: D000256:Adenoviridae / Q000235:genetics* / Q000502:physiology; D017500:Adenovirus E1A Proteins / Q000172:deficiency* / Q000235:genetics; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000628:therapy* / Q000821:virology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival; D000071877:Checkpoint Kinase 1; D002945:Cisplatin / Q000627:therapeutic use; D003588:Cytopathogenic Effect, Viral / Q000502:physiology; D016373:DNA, Antisense / Q000235:genetics; D005260:Female; D018390:Gene Targeting; D005822:Genetic Vectors / Q000008:administration & dosage / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000628:therapy* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D014779:Virus Replication; D023041:Xenograft Model Antitumor Assays
chemical_list: D017500:Adenovirus E1A Proteins; D000970:Antineoplastic Agents; D016373:DNA, Antisense; D011494:Protein Kinases; C000605867:CHEK1 protein, human; D000071877:Checkpoint Kinase 1; C000605869:Chek1 protein, mouse; D002945:Cisplatin