title: Discovery of novel heterocyclic factor VIIa inhibitors.
abstract: Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
authors.affiliation: Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. roopa.rai@hotmail.com
authors.forename: Roopa
authors.initials: R
authors.lastname: Rai
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Kolesnikov
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sprengeler
authors.forename: Steven
authors.initials: S
authors.lastname: Torkelson
authors.forename: Tony
authors.initials: T
authors.lastname: Ton
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Katz
authors.forename: Christine
authors.initials: C
authors.lastname: Yu
authors.forename: John
authors.initials: J
authors.lastname: Hendrix
authors.forename: William D
authors.initials: WD
authors.lastname: Shrader
authors.forename: Robin
authors.initials: R
authors.lastname: Stephens
authors.forename: Ronnell
authors.initials: R
authors.lastname: Cabuslay
authors.forename: Ellen
authors.initials: E
authors.lastname: Sanford
authors.forename: Wendy B
authors.initials: WB
authors.lastname: Young
mesh_terms: D000631:Aminopyridines / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D018360:Crystallography, X-Ray; D015195:Drug Design; D015942:Factor VIIa / Q000037:antagonists & inhibitors*; D005343:Fibrinolytic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D013925:Thromboplastin / Q000037:antagonists & inhibitors*
chemical_list: D000631:Aminopyridines; D005343:Fibrinolytic Agents; D006571:Heterocyclic Compounds; D013925:Thromboplastin; D015942:Factor VIIa