title: [Chronic myelomonocytic leukemia with pleural effusion as the first clinical sign].
abstract: We report a chronic myelomonocytic leukemia (CMML) patient whose initial symptom was pleural effusion, which is extremely rare. A 61-year-old male was referred to our hospital because of leukocytosis with blasts and pleural effusion with chest pain. Bone marrow examination showed trilineage dysplasia with 14% blasts and a normal karyotype. He was diagnosed as having MDS (RAEB) and infectious pleuritis on admission. Despite administration of antibiotics, leukocytosis with monocytosis and pleural effusion progressed rapidly. His diagnosis was then changed to CMML-2 and pleural infiltration due to leukemic cells expressing CD13, CD14 and CD33. After the leukocytosis was brought under control with hydroxycarbamide, the patient's pleural effusion disappeared.
authors.affiliation: Division of Hematology and Immunology, Fujisawa City Hospital.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Yamazaki
authors.forename: Makiko
authors.initials: M
authors.lastname: Kanai
authors.forename: Rika
authors.initials: R
authors.lastname: Sakai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D017254:Leukemic Infiltration / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000473:pathology; D010996:Pleural Effusion / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea