Natural regulatory T cells control the development of atherosclerosis in mice.
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.
Ait-Oufella
Hafid
H
Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 689, Centre de Recherche Cardiovasculaire Lariboisière, 41, Bd de la Chapelle, 75010 Paris, France.
Salomon
Benoît L
BL
Potteaux
Stéphane
S
Robertson
Anna-Karin L
AK
Gourdy
Pierre
P
Zoll
Joffrey
J
Merval
Régine
R
Esposito
Bruno
B
Cohen
José L
JL
Fisson
Sylvain
S
Flavell
Richard A
RA
Hansson
Göran K
GK
Klatzmann
David
D
Tedgui
Alain
A
Mallat
Ziad
Z
D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D018122:B7-1 Antigen / Q000235:genetics; D018106:CD28 Antigens / Q000235:genetics; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics; D005260:Female; D007113:Immunity, Innate; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology
D001057:Apolipoproteins E; D018122:B7-1 Antigen; D018106:CD28 Antigens; D004268:DNA-Binding Proteins; C499308:Rag2 protein, mouse