Cortistatin-17 and somatostatin-14 display the same effects on growth hormone, prolactin, and insulin secretion in patients with acromegaly or prolactinoma.
BACKGROUND
Cortistatin binds all somatostatin receptor subtypes but also has particular central actions; moreover, a specific cortistatin receptor has also been discovered.


OBJECTIVE
We compared the endocrine effects of cortistatin-17 with those of somatostatin-14 in patients with acromegaly (ACRO) or prolactinoma (PRLOMA). Normal subjects (NS) were studied as control group.


METHODS
All subjects underwent the following tests: 1) saline, 2) somatostatin-14 (2.0 microg/kg.h iv, 0-120 min) and 3) cortistatin-17 (2.0 microg/kg.h iv, 0-120 min) infusion.


RESULTS
Cortistatin-17 and somatostatin-14 inhibited GH secretion to the same extent in ACRO (P < 0.05) and NS (P < 0.01). Cortistatin-17 and somatostatin-14 inhibited PRL secretion in PRLOMA (P < 0.05), to some extent in ACRO (P value not significant), but not in NS. Insulin secretion was inhibited by both cortistatin-17 and somatostatin-14 to the same extent in all groups (P < 0.05).


CONCLUSIONS
Cortistatin-17 and somatostatin-14 display the same effects on GH, PRL, and insulin secretion in patients with ACRO or PRLOMA.
Grottoli
S
S
Division of Endocrinology and Metabolism, Department of Internal Medicine, San Giovanni Battista-Molinette Hospital, Corso Dogliotti 14, 10126 Turin, Italy.
Gasco
V
V
Broglio
F
F
Baldelli
R
R
Ragazzoni
F
F
Gallenca
F
F
Mainolfi
A
A
Prodam
F
F
Muccioli
G
G
Ghigo
E
E
D000172:Acromegaly / Q000097:blood*; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002352:Carrier Proteins / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005949:Glucose Oxidase / Q000378:metabolism; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000009:adverse effects / Q000494:pharmacology; D010911:Pituitary Neoplasms / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D015175:Prolactinoma / Q000097:blood*; D013004:Somatostatin / Q000009:adverse effects / Q000494:pharmacology*
D001786:Blood Glucose; C105172:CORT protein, human; D002352:Carrier Proteins; D007328:Insulin; D009479:Neuropeptides; D019382:Human Growth Hormone; D013004:Somatostatin; D011388:Prolactin; D005949:Glucose Oxidase