title: Bone augmentation with bioactive glass in three cases of dental implant placement.
abstract: This study reports the clinical use of a bioactive bone graft material, PerioGlas, in the treatment of dental extraction sites before dental implant placement, to effect bone regeneration and to give early fixation to the implant.PerioGlas, granules, ranging from 90 to 710 mm, are implanted after tooth extraction in three patients; after 6 months bone biopsies were performed in the site of the glass implantation and observed under Electron Scanning Microscopy. All the granules showed a biodegradation involving precipitation of calcium phosphate that worked as a scaffold for osteoblasts colonization. All cases examined showed the bioactivity of PerioGlas granules resulting in new bone formation and biodegradation of the glass. After a two-year clinical follow-up all the implants were successfully loaded and appeared stable.
authors.affiliation: The National Institute of Physics of Matter, Laboratory of Biomaterials, Department of Neurosciences, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena - Italy. gatti@unimo.it
authors.forename: Antonietta M
authors.initials: AM
authors.lastname: Gatti
authors.forename: Leopoldo A
authors.initials: LA
authors.lastname: Simonetti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Monari
authors.forename: Stefano
authors.initials: S
authors.lastname: Guidi
authors.forename: David
authors.initials: D
authors.lastname: Greenspan
mesh_terms: D000328:Adult; D018786:Bone Substitutes / Q000737:chemistry*; D016025:Bone Transplantation / Q000295:instrumentation* / Q000379:methods; D002516:Ceramics / Q000737:chemistry*; D003758:Dental Implantation, Endosseous / Q000295:instrumentation* / Q000379:methods; D019250:Dental Implants, Single-Tooth; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008963:Molar / Q000502:physiology / Q000601:surgery* / Q000648:ultrastructure; D016348:Osseointegration / Q000502:physiology; D013499:Surface Properties; D014081:Tooth Extraction; D016896:Treatment Outcome
chemical_list: C022107:Bioglass; D018786:Bone Substitutes