Combining evidence for association from transmission disequilibrium and case-control studies using single-nucleotide polymorphisms.
The aim of the present analysis is to combine evidence for association from the two most commonly used designs in genetic association analysis, the case-control design and the transmission disequilibrium test (TDT) design. The cases here are affected offspring from nuclear families and are used in both the case-control and TDT designs. As a result, inference from these designs is not independent. We applied a simple logistic regression method for combining evidence for association from case-control and TDT designs to single-nucleotide polymorphism data purchased on a region on chromosome 3, replicate 1 of the Aipotu population. Combining the evidence from the case-control and TDT designs yielded a 5-10% reduction in the standard errors of the relative risk estimates. The authors did not know the results before the analyses were conducted.
Putter
Hein
H
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, University of Leiden, PO Box 9604, 2300 RC, Leiden, The Netherlands. h.putter@lumc.nl
Houwing-Duistermaat
Jeanine J
JJ
Nagelkerke
Nico J D
NJ
D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*