Methylglyoxal comes of AGE.
The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.
Ramasamy
Ravichandran
R
Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Yan
Shi Fang
SF
Schmidt
Ann Marie
AM
D000375:Aging / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D016678:Genome / Q000187:drug effects; D017127:Glycation End Products, Advanced / Q000096:biosynthesis*; D006031:Glycosylation; D006801:Humans; D020543:Proteome / Q000187:drug effects; D011765:Pyruvaldehyde / Q000378:metabolism* / Q000494:pharmacology
D017127:Glycation End Products, Advanced; D020543:Proteome; D011765:Pyruvaldehyde