Association between heat shock protein 70s and toll-like receptor polymorphisms with long-term renal allograft survival.
Long-term renal allograft survival has not improved significantly in recent years and only a minority of grafts survives for more than 15 years. To evaluate the association between HSPA1A G(190)C, HSPA1B A(1267)G and TLR4 A(299)G polymorphisms and allograft survival we analyzed DNA of patients with long-term renal graft function over 15 years (Tx15), consecutively transplanted recipients (Tx), patients with acute rejection and healthy controls. HSPA1B (1267)AA was less prevalent in Tx versus Tx15 (P = 0.02) and versus controls (P = 0.004). HSPA1B (1267)GG was more frequent in Tx versus Tx15 (P = 0.005) and versus controls (P = 0.002). HSPA1B (1267)G allele occurred more often in Tx versus Tx15 (P = 0.03), and versus controls (P = 0.02). TLR4 (299)AG genotype prevalence was increased in Tx15 versus Tx (P = 0.02), while TLR4 (299)G allele was more frequent in Tx15 versus Tx (P = 0.02). The increased frequency of HSPA1B (1267)AA and TLR4 (299)AG genotypes in Tx15 group indicates that better cytoprotective functions in HSPA1B (1267)AA and reduced proinflammatory response in TLR4 (299)AG carriers might have improved renal allograft survival.
Fekete
Andrea
A
Research Laboratory of Paediatrics and Nephrology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.
Viklický
Ondrej
O
Hubácek
Jaroslav A
JA
Rusai
Krisztina
K
Erdei
Gábor
G
Treszl
András
A
Vítko
Stefan
S
Tulassay
Tivadar
T
Heemann
Uwe
U
Reusz
György
G
Szabó
Attila J
AJ
D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006085:Graft Survival; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics* / Q000502:physiology*; D050884:HSP72 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011110:Polymorphism, Genetic; D013997:Time Factors; D051195:Toll-Like Receptor 2 / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000378:metabolism; D051193:Toll-Like Receptors / Q000235:genetics* / Q000502:physiology*
D018840:HSP70 Heat-Shock Proteins; D050884:HSP72 Heat-Shock Proteins; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors