title: Hemorheological follow-up after splenectomy and spleen autotransplantation in mice.
abstract: We previously reported on a spleen autotransplantation model in mice, with spleen function studies at 6 weeks. The present study was undertaken to investigate long-term hemorheological functions. A/J and BALB/c inbred mice were divided into four groups: control, sham surgery (SH), splenectomy (SE), and spleen autotransplantation (AU). Hematological and hemorheological parameters were determined. Leukocyte counts in the SE and AU groups were significantly higher than in controls, while hematocrit levels were markedly lower. Mean erythrocyte volume did not change significantly. Platelet counts in the AU group were significantly lower, and red blood cell deformability was significantly worse in the SE group. The AU group also had increased cell transit time, but it was less than that in the SE group. The SE group showed the highest fibrinogen levels. We conclude that there are some consistent differences in hematological parameters between splenectomy and spleen autotransplantation. These data suggest that spleen autotransplantation may partially restore hemorheological functions following splenectomy.
authors.affiliation: Department of Operative Techniques and Surgical Research, Medical and Health Science Center, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. imiko@jaguar.unideb.hu
authors.forename: Iren
authors.initials: I
authors.lastname: Miko
authors.forename: Norbert
authors.initials: N
authors.lastname: Nemeth
authors.forename: Sandor
authors.initials: S
authors.lastname: Sipka
authors.forename: Endre
authors.initials: E
authors.lastname: Brath
authors.forename: Katalin
authors.initials: K
authors.lastname: Peto
authors.forename: Adrienn
authors.initials: A
authors.lastname: Gulyas
authors.forename: Istvan
authors.initials: I
authors.lastname: Furka
authors.forename: Robert
authors.initials: R
authors.lastname: Zhong
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D004907:Erythrocyte Deformability; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D018056:Hemorheology; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000637:transplantation*; D013156:Splenectomy; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D006454:Hemoglobins