[Development of polymeric nanoparticles-based vaccine].
Traditional vaccines are mainly composed of attenuated or heat-inactivated viruses. These vaccines often generate many unwanted side effects. Subunit protein and peptide vaccines are generally very safe vaccines with well-defined components. However, proteins and peptides are often poorly immunogenic and thus require the use of adjuvants to induce adequate immunity. Therefore, particulate adjuvants have been widely investigated in vaccine delivery systems. In particular, polymeric nanoparticles with entrapped antigens represent an exciting approach to control the release of vaccine antigens and optimize the desired immune response via selective targeting of antigen to professional antigen presenting cells. It is expected that biodegradable polymeric nanoparticles have great potential as carriers for systemic and mucosal vaccine delivery systems.
Akagi
Takami
T
Department of Applied Chemistry, Graduate School of Engineering, Osaka University.
Akashi
Mitsuru
M
D000941:Antigens / Q000276:immunology; D001673:Biodegradation, Environmental; D016503:Drug Delivery Systems; D049329:Nanostructures; D011108:Polymers; D014612:Vaccines
D000941:Antigens; D011108:Polymers; D014612:Vaccines