title: Growing biological networks: beyond the gene-duplication model.
abstract: In this paper we propose a generalized growth model for biological interaction networks, including a set of biological features which have been inspired by a long tradition of simulations of immune system and chemical reaction networks. In our models we include characteristics such as the heterogeneity of biological nodes, the existence of natural hubs, the nodes binding by mutual affinity and the significance of type-based networks as compared with instance-based networks. Under these assumptions, we analyse the importance of the nodes concentration with respect to the selection of incoming nodes. We show that networks with fat-tailed degree distribution and highly clustered structure naturally emerge in systems possessing certain properties: new instances need to be produced through an endogenous source and this source needs to provide a positive feedback favouring nodes with high concentration to receive new connections. Furthermore, we show that understanding the concentration dynamics of each node and the consequent correlation between connectivity and concentration is a more adequate way to capture the global properties of type-based biological networks.
authors.affiliation: IRIDIA, CP 194/6, Université Libre de Bruxelles, Avenue Franklin Roosevelt 50, 1050 Brussels, Belgium. bersini@ulb.ac.be
authors.forename: Hugues
authors.initials: H
authors.lastname: Bersini
authors.forename: Tom
authors.initials: T
authors.lastname: Lenaerts
authors.forename: Francisco C
authors.initials: FC
authors.lastname: Santos
mesh_terms: D000818:Animals; D005246:Feedback / Q000502:physiology; D020440:Gene Duplication; D006128:Growth; D008954:Models, Biological; D008957:Models, Genetic; D049490:Systems Biology