MRI findings of hypoxic cortical laminar necrosis in a child with hemolytic anemia crisis.
We present magnetic resonance imaging findings of a 5-year-old girl who had a rapidly installing hemolytic anemia crisis induced by trimethoprim-sulfomethoxazole, resulting in cerebral anoxia leading to permanent damage. Magnetic Resonance imaging revealed cortical laminar necrosis in arterial border zones in both cerebral hemispheres, ischemic changes in subcortical white matter of left cerebral hemisphere, and in the left putamen. Although cortical laminar necrosis is a classic entity in adulthood related to conditions of energy depletions, there are few reports available in children. A wide review of the literature is also presented.
Kizilkilic
Osman
O
Department of Radiology, Division of Neuroradiology, Cerrahpasa Medical Faculty, 34300 Istanbul, Turkey.
Albayram
Sait
S
Kasapcopur
Ozgür
O
Mihmanli
Ismail
I
Kocer
Naci
N
Islak
Civan
C
D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000150:complications*; D000890:Anti-Infective Agents / Q000009:adverse effects; D001139:Arnold-Chiari Malformation / Q000175:diagnosis; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology; D002540:Cerebral Cortex / Q000473:pathology; D002675:Child, Preschool; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D011699:Putamen / Q000473:pathology; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination