title: Defining the toxic mode of action of ester sulphonates using the joint toxicity of mixtures.
abstract: Previously we have presented aquatic toxicity data for the class of anionic surfactant ester sulphonates (ES) to Daphnia magna. We now present toxicity data for binary mixtures of ES substances with reference substances of known mode of action. Using a toxic unit (TU) approach, data indicated that ES substances exhibit concentration addition with linear alkylbenzene sulphonate (LAS) and phenols and response addition with alcohols. This suggests that ES behave with a similar mode of action to phenol and LAS which are known polar narcotics and with a dissimilar mode of action to alcohols which are known baseline narcotics.
authors.affiliation: SEAC, Unilever Colworth, Sharnbrook, Bedfordshire MK44 1LQ, United Kingdom. geoff.hodges@unilever.com
authors.forename: Geoff
authors.initials: G
authors.lastname: Hodges
authors.forename: David W
authors.initials: DW
authors.lastname: Roberts
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Marshall
authors.forename: John C
authors.initials: JC
authors.lastname: Dearden
mesh_terms: D000438:Alcohols / Q000633:toxicity; D000476:Alkanesulfonates / Q000633:toxicity*; D017738:Alkanesulfonic Acids / Q000633:toxicity; D000818:Animals; D003621:Daphnia / Q000187:drug effects* / Q000502:physiology; D004347:Drug Interactions; D009294:Narcotics / Q000633:toxicity*; D019800:Phenol / Q000633:toxicity; D013501:Surface-Active Agents / Q000633:toxicity; D023382:Toxicity Tests, Acute; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D000438:Alcohols; D000476:Alkanesulfonates; D017738:Alkanesulfonic Acids; D009294:Narcotics; D013501:Surface-Active Agents; D014874:Water Pollutants, Chemical; C030641:alkylbenzyl sulfonic acid; D019800:Phenol