6-Hydroxydopamine lesions of nucleus accumbens core abolish amphetamine-induced conditioned activity.
Environmental cues associated with drug experiences appear to play a critical role in drug dependence. We have previously reported that dopamine-depleting lesions of the nucleus accumbens medial shell inhibit amphetamine-conditioned place preference. Here, we examined the effects of analogous lesions on amphetamine-conditioned locomotor activity. Bilateral core, but not medial shell, lesions attenuated unconditioned locomotion and abolished the conditioned locomotor response. Taken with our previous results, these findings confirm a role for accumbens core in amphetamine-induced locomotor activity and suggest that the role of medial shell DA transmission in conditioned place preference is related to reward processing rather than conditioning in general.
Sellings
Laurie H L
LH
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Clarke
Paul B S
PB
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001667:Binding, Competitive / Q000187:drug effects; D003042:Cocaine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D003216:Conditioning, Operant / Q000187:drug effects*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000187:drug effects* / Q000293:injuries / Q000502:physiology; D016627:Oxidopamine / Q000633:toxicity; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D020318:Rats, Long-Evans; D013565:Sympatholytics / Q000633:toxicity; D014316:Tritium / Q000493:pharmacokinetics
D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D019275:Radiopharmaceuticals; D013565:Sympatholytics; D014316:Tritium; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D016627:Oxidopamine; D000661:Amphetamine; D003042:Cocaine