Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release.
Directly compressed mini tablets were produced containing either hydroxypropylmethylcellulose (HPMC) or ethylcellulose (EC) as release controlling agent. The dynamics of water uptake and erosion degree of polymer were investigated. By changing the polymer concentration, the ibuprofen release was modified. In identical quantities, EC produced a greater sustaining release effect than HPMC. Different grades of viscosity of HPMC did not modify ibuprofen release. For EC formulations, the contribution of diffusion was predominant in the ibuprofen release process. For HPMC preparations, the drug release approached zero-order during a period of 8 h. For comparative purposes, tablets with 10 mm diameter were produced.
Lopes
Carla M
CM
Department of Pharmaceutical Technology, Faculty of Pharmacy, Oporto University, Rua Aníbal Cunha, 164-4050-047, Porto - Portugal. clopes@ff.up.pt
Sousa Lobo
José Manuel
JM
Costa
Paulo
P
Pinto
João F
JF
D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D003692:Delayed-Action Preparations; D065347:Hypromellose Derivatives; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical; D014783:Viscosity
D003692:Delayed-Action Preparations; D013607:Tablets; D065347:Hypromellose Derivatives; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose; D007052:Ibuprofen