title: Effect of N-acetylcysteine on oxidative stress and ventricular function in patients with myocardial infarction.
abstract: Recent evidence suggests that postischemic myocardial dysfunction ("stunning") may be mediated by oxygen free radicals. Various studies have reported the beneficial effects of antioxidants in ischemia-reperfusion injury. The aim of this study was to assess the effect of N-acetylcysteine (NAC) treatment on oxidative stress, infarct size, and left ventricular (LV) function, as adjunct therapy in myocardial infarction (MI). Patients with acute MI received either 15 g NAC infused over 24 h (n = 15) or no NAC (n = 15), combined with streptokinase. Peripheral venous blood was serially sampled to measure creatine kinase (CK)-MB levels. Plasma malondialdehyde (MDA) level was measured at admission and after 4 and 24 h. Echocardiography was performed within 3 days of MI and after 3 months. At admission, plasma MDA levels were not different between the groups. In the NAC-treated patients plasma MDA levels decreased, whereas in the nontreated NAC patients MDA levels increased at 4 and 24 h (P < 0.01 and P < 0.001, respectively). Left ventricular ejection fraction was higher (P < 0.05) and LV end-systolic and end-diastolic diameters were lower (P < 0.001 and P < 0.001) in patients receiving NAC on day 3. Left ventricular wall motion score index was significantly lower in patients treated with NAC on day 3 (P < 0.05). Left ventricular diastolic parameters were not different whether patients were treated with NAC or not. No difference in reduction of infarct size was detected between the groups according to CK-MB levels. It was thus demonstrated that administration of NAC in combination with streptokinase significantly diminished oxidative stress and improved LV function in patients with acute MI. These encouraging results would justify the performance of a larger controlled study.
authors.affiliation: Cardiology Department, Uludag University Medical School, Kardiyoloji Anabilim Dali, Gorukle, Bursa, Turkey. dilekyb@uludag.edu.tr
authors.forename: Dilek
authors.initials: D
authors.lastname: Yesilbursa
authors.forename: Akin
authors.initials: A
authors.lastname: Serdar
authors.forename: Tunay
authors.initials: T
authors.lastname: Senturk
authors.forename: Zehra
authors.initials: Z
authors.lastname: Serdar
authors.forename: Saim
authors.initials: S
authors.lastname: Sağ
authors.forename: Jale
authors.initials: J
authors.lastname: Cordan
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood / Q000187:drug effects; D004359:Drug Therapy, Combination; D015150:Echocardiography, Doppler; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D005996:Nitroglycerin / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects*; D012107:Research Design; D013300:Streptokinase / Q000627:therapeutic use; D013318:Stroke Volume / Q000187:drug effects; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use; D016277:Ventricular Function, Left / Q000187:drug effects*; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D015415:Biomarkers; D005343:Fibrinolytic Agents; D016166:Free Radical Scavengers; D014665:Vasodilator Agents; D008315:Malondialdehyde; D052279:Creatine Kinase, MB Form; D013300:Streptokinase; D005996:Nitroglycerin; D000111:Acetylcysteine