Interdigitating dendritic cell sarcoma of the duodenum with rapidly fatal course: a case report and review of the literature.
Interdigitating dendritic cell sarcoma is an extremely rare malignancy derived from antigen-presenting cells. Dendritic cells constitute a heterogeneous group of cells, which includes Langerhans cells, dermal dendrocytes, follicular dendritic cells, and interdigitating dendritic cells present in lymphoid and nonlymphoid organs. We report the case of a 36-year-old woman who presented with epigastric pain, projectile vomiting, and significant weight loss. Upper gastrointestinal endoscopy showed a duodenal lesion; a biopsy of the lesion was taken and was diagnosed as sarcoma. She underwent a Whipple procedure. A final diagnosis of interdigitating dendritic cell sarcoma was made, with liver and peripancreatic lymph node involvement. The patient deteriorated rapidly and died 4 months later. Although interdigitating dendritic cell sarcoma of the duodenum is extremely rare, we think it should be included in the differential diagnosis of unusual spindle cell tumors with a rich lymphocytic infiltrate.
Kanaan
Hassan
H
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. hkanaan@hotmail.com
Al-Maghrabi
Jaudah
J
Linjawi
Ayman
A
Al-Abbassi
Amira
A
Dandan
Abdelghani
A
Haider
Abdul Razzaq
AR
D000328:Adult; D003713:Dendritic Cells / Q000473:pathology*; D003937:Diagnosis, Differential; D004379:Duodenal Neoplasms / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery