How to select the right mouthrinses in periodontal prevention and therapy. Part I. Test systems and clinical investigations.
The use of mouthrinses is increasing, especially as adjuncts to the daily mechanical oral hygiene. Different test systems may and can be used to test their antibacterial and clinical effects: bacteriology in vitro, substantivity in vivo, 4-day plaque re-growth, experimental gingivitis and long-term use. The plaque re-growth investigations of a few days are not only of limited use but may also be dangerous because often too extensive conclusions have been drawn from their design. The 'gold standard' test is the experimental gingivitis model to reveal the antiplaque as well as the antigingivitis effects of any mouthrinse preparation during 3 weeks. The last kind of investigations are of several months' duration, where the substances are used as supplements to mechanical oral hygiene measures.
Netuschil
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Department of Conservative Dentistry, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany.
Hoffmann
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Brecx
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D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control / Q000628:therapy; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D009067:Mouthwashes / Q000627:therapeutic use*; D009910:Oral Hygiene; D010510:Periodontal Diseases / Q000188:drug therapy / Q000517:prevention & control*; D013997:Time Factors
D000891:Anti-Infective Agents, Local; D009067:Mouthwashes