Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology.
Gastrointestinal stromal tumours (GIST) are rare in children. A 7-year-old boy presented acutely with a severe upper gastrointestinal bleed and was found following angiography to have such a tumour in the duodenum, which was resected at laparotomy. The presence of CD 117 positive immunostaining was a confirmatory diagnostic marker. The prognosis and underlying molecular biology of the tumour is discussed. Understanding of the molecular pathogenesis has given rise to promising new therapies.
Towu
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Department of Paediatric Surgery, Lewisham University Hospital NHS Trust, Lewisham High Street, London, SE13 6LH, UK.
Stanton
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D002648:Child; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D046152:Gastrointestinal Stromal Tumors / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism
D019009:Proto-Oncogene Proteins c-kit