Normal CD16 expression and phagocytosis of Mycobacterium avium complex by monocytes from a current cohort of HIV-1-infected patients.
Monocyte phenotype and function were measured in whole blood sampled from a current cohort of human immunodeficiency virus (HIV)-infected individuals attending a large, metropolitan, university-affiliated hospital. There was no significant difference in the prevalence of CD16+ monocytes or the capacity of monocytes to ingest heat-killed Mycobacterium avium complex between these individuals and HIV-uninfected control subjects, regardless of viral load, current CD4+ T cell count, nadir CD4+ T cell count, or time since diagnosis of HIV infection. CD16+ monocyte prevalence was, however, elevated in patients not currently receiving antiretroviral therapy. We conclude that HIV type 1 infection in the setting of highly active antiretroviral therapy is associated with normal monocyte function and phenotype.
Jaworowski
Anthony
A
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, and Department of Medicine, Monash University, Clayton, Australia. anthonyj@burnet.edu.au
Ellery
Philip
P
Maslin
Clare L
CL
Naim
Eman
E
Heinlein
Amy Candy
AC
Ryan
Claire E
CE
Paukovics
Geza
G
Hocking
Jane
J
Sonza
Secondo
S
Crowe
Suzanne M
SM
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015703:Antigens, CD / Q000032:analysis*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D058851:GPI-Linked Proteins; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis*; D009000:Monocytes / Q000276:immunology*; D015269:Mycobacterium avium Complex / Q000276:immunology*; D010587:Phagocytosis; D011971:Receptors, Immunologic / Q000032:analysis*; D013997:Time Factors; D019562:Viral Load
D019380:Anti-HIV Agents; D015703:Antigens, CD; C114505:CD160 protein, human; D058851:GPI-Linked Proteins; D008565:Membrane Proteins; D011971:Receptors, Immunologic