title: Topical anaesthesia before nasendoscopy: a randomized controlled trial of co-phenylcaine compared with lignocaine.
abstract: OBJECTIVE
  To evaluate the relative effectiveness of co-phenylcaine (lignocaine 5% with phenylephrine) and lignocaine 5% sprays when administered prior to rigid nasendoscopy.
  
  
  METHODS
  Randomized, double blind controlled study.
  
  
  METHODS
  Teaching hospital otolaryngology unit.
  
  
  METHODS
  Thirty patients requiring routine outpatient rigid nasendoscopy were administered five puffs of either co-phenylcaine or lignocaine 5% spray which had been randomly assigned to either the first or the second visit. Ten minutes later nasendoscopy was performed. Immediately after nasendoscopy the ease of performance of the procedure and the quality of the view achieved was rated on a visual analogue scale by the endoscopist and the patients recorded the level of pain experienced on a visual analogue scale. Two weeks later, the patients returned for a repeat nasendoscopy, receiving the alternate spray.
  
  
  METHODS
  Ease of performance and quality of view of achieved by endoscopists and pain experienced by patients, both measured with visual analogue scales.
  
  
  RESULTS
  The ease of passage of the endoscope and quality of the view obtained was found to be greater after the administration of co-phenylcaine [visual analogue scores 84 (95% CI: 80-89) than after lignocaine and 77 (95% CI: 73-81) (P < 0.01)]. The two sprays produced similar levels of topical anaesthesia.
  
  
  CONCLUSIONS
  Nasendoscopy can be performed with minimal discomfort after the administration of either co-phenylcaine or lignocaine 5% sprays. The vasoconstricting action of co-phenylcaine increases the ease of passage of the endoscope and quality of the view obtained by the endoscopist.
authors.affiliation: Department of Surgery, Otolaryngology Head and Neck Surgery, Adelaide and Flinders Universities, Woodville South, SA, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Douglas
authors.forename: L
authors.initials: L
authors.lastname: Hawke
authors.forename: P-J
authors.initials: PJ
authors.lastname: Wormald
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000336:Aerosols; D000368:Aged; D000772:Anesthesia, Local / Q000592:standards; D000779:Anesthetics, Local / Q000008:administration & dosage; D004311:Double-Blind Method; D004724:Endoscopy / Q000009:adverse effects / Q000592:standards; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D014663:Nasal Decongestants / Q000008:administration & dosage; D010147:Pain Measurement; D010656:Phenylephrine / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D000779:Anesthetics, Local; D014663:Nasal Decongestants; D010656:Phenylephrine; D008012:Lidocaine