title: Selected Rofams as a micellar solubilizers for diclofenac and naproxen in the environment of the standard vehicle for eye drops.
abstract: The process of the equilibrium solubilization of nonsteroidal anti-inflammatory drugs (NSAID), viz. diclofenac and naproxen, by Rofams, ie. the products of the oxyethylenating of the rape oil fatty acid methyl esters, in the environment of water solutions NaCl 9 g/l, H3BO3 19 g/l, KNO3 16 g/l, was tested. The solubilization activity of Rofam aqueous solutions was estimated with the use of the spectrophotometric method by means of the determination of the amount of the solubilized NSAID. The calculated apparent solubility of Rofam aqueous solutions was the basis for the estimation of the micellar partition coefficient K(w)m. The course of the ratio of the solubilized naproxen and diclofenac in the function of the solubilizer (Rofam R-13, R-15, R-17) exposure concentration was described by means of approximative equations with a high correlation coefficient.
authors.affiliation: Department of Drug Form Technology, Applied Pharmacy Faculty, Medical University, Lodz.
authors.forename: Michał Jakub
authors.initials: MJ
authors.lastname: Nachajski
authors.forename: Marian Mikołaj
authors.initials: MM
authors.lastname: Zgoda
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D004008:Diclofenac / Q000737:chemistry*; D008823:Micelles; D009288:Naproxen / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D012995:Solubility; D012996:Solutions / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008823:Micelles; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D012996:Solutions; D014867:Water; D004008:Diclofenac; D009288:Naproxen