title: Parathyroid carcinoma in a chronic hemodialysis patient: case report and review of the literature.
abstract: Parathyroid carcinoma is a rare disease in normal population as well as in patients with end-stage renal disease. Approximately 700 cases have been reported and, of these, 20 occurred in patients receiving chronic hemodialysis. We describe a case of parathyroid carcinoma in a 59-year-old female patient with end-stage renal disease secondary to membranous glomerulonephritis treated by hemodialysis since 1995. In September 1998, the calcium level was 12.4 mg/dl and intact parathyroid hormone serum levels were 1366 pg/ml (normal range, 25-65). A routine ultrasonographic examination of the neck revealed enlargement of two parathyroid glands, the left inferior gland being the largest and measuring 2x3x2 cm. In October 1998, resection of two parathyroid glands was performed. On the basis of histology, which documented the presence of proliferating cells arranged in sheets or in a trabecular pattern, numerous mitosis and vascular invasion, a diagnosis of parathyroid carcinoma was made.
authors.affiliation: Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo Gemelli 8, 00168 Rome, Italy. maubosso@tin.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bossola
authors.forename: Luigi
authors.initials: L
authors.lastname: Tazza
authors.forename: Angela
authors.initials: A
authors.lastname: Ferrante
authors.forename: Stefania
authors.initials: S
authors.lastname: Giungi
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Carbone
authors.forename: Daniele
authors.initials: D
authors.lastname: Gui
authors.forename: Giovanna
authors.initials: G
authors.lastname: Luciani
mesh_terms: D002118:Calcium / Q000097:blood; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006435:Renal Dialysis
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium