title: The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor.
abstract: Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved by the presence of one or two basic amine functional groups.
authors.affiliation: Pfizer Global Research and Development, Groton/NewLondon Laboratories, Groton, CT 06340, USA. michael.p.deninno@pfizer.com
authors.forename: Michael P
authors.initials: MP
authors.lastname: DeNinno
authors.forename: Hiroko
authors.initials: H
authors.lastname: Masamune
authors.forename: Lois K
authors.initials: LK
authors.lastname: Chenard
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: DiRico
authors.forename: Cynthia
authors.initials: C
authors.lastname: Eller
authors.forename: John B
authors.initials: JB
authors.lastname: Etienne
authors.forename: Jeanene E
authors.initials: JE
authors.lastname: Tickner
authors.forename: Scott P
authors.initials: SP
authors.lastname: Kennedy
authors.forename: Delvin R
authors.initials: DR
authors.lastname: Knight
authors.forename: Jimmy
authors.initials: J
authors.lastname: Kong
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Oleynek
authors.forename: W Ross
authors.initials: WR
authors.lastname: Tracey
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Hill
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D058909:Adenosine A3 Receptor Agonists; D006801:Humans; D008968:Molecular Conformation; D012995:Solubility; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D058909:Adenosine A3 Receptor Agonists; D014867:Water; D000241:Adenosine