title: Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome.
abstract: BACKGROUND
  Asperger syndrome is characterised by abnormalities in social interaction as well as repetitive and stereotyped behaviours and interests. The trait is thought to display complex inheritance, but in a subset of families the inheritance resembles the autosomal dominant model. Linkage to 3p14-24 has recently been reported in Asperger syndrome in Finnish families with a maximum multipoint NPL(all) of 3.32 at D3S2432.
  
  
  METHODS
  We have replicated linkage findings to 3p21-24 in 12 new extended Asperger syndrome families. Linkage analyses were performed separately for the 12 new families, and linkage and association analyses were also performed jointly with data from the original genome-wide screen.
  
  
  RESULTS
  Best two point and multipoint logarithm of the odds (LOD) scores in analyses of both data sets were obtained at D3S2432 (NPL(all) = 3.83) with both subsets of families contributing to linkage. Association analysis of the combined data set produced a trend towards association with D3S2432 and D3S1619.
  
  
  CONCLUSIONS
  This study further validates 3q21-24 as a candidate region for Asperger syndrome.
authors.forename: K
authors.initials: K
authors.lastname: Rehnström
authors.forename: T
authors.initials: T
authors.lastname: Ylisaukko-oja
authors.forename: T
authors.initials: T
authors.lastname: Nieminen-von Wendt
authors.forename: S
authors.initials: S
authors.lastname: Sarenius
authors.forename: T
authors.initials: T
authors.lastname: Källman
authors.forename: E
authors.initials: E
authors.lastname: Kempas
authors.forename: L
authors.initials: L
authors.lastname: von Wendt
authors.forename: L
authors.initials: L
authors.lastname: Peltonen
authors.forename: I
authors.initials: I
authors.lastname: Järvelä
mesh_terms: D020817:Asperger Syndrome / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D020161:Physical Chromosome Mapping; D015203:Reproducibility of Results
chemical_list: D005819:Genetic Markers