Resibufogenin corrects hypertension in a rat model of human preeclampsia.
The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.
Vu
Hop
H
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Ianosi-Irimie
Monica
M
Danchuk
Svitlana
S
Rabon
Edd
E
Nogawa
Toshihiko
T
Kamano
Yoshiaki
Y
Pettit
G Robert
GR
Wiese
Thomas
T
Puschett
Jules B
JB
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002018:Bufanolides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D010042:Ouabain / Q000378:metabolism; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism
D002018:Bufanolides; D004791:Enzyme Inhibitors; D007527:Isoenzymes; C005734:bufogenin; C093896:marinobufagenin; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase