p-hydroxylation reactions catalyzed by naphthalene dioxygenase.
In this study, naphthalene dioxygenase is shown to catalyze the oxidation of methylphenols and chlorophenols by p- and/or o-hydroxylation reactions. For instance, m-cresol was oxidized to methylhydroquinone with formation of 3- and 4-methylcatechol as minor products. 2-Chlorophenol was exclusively oxidized to chlorohydroquinone, which is an important building block for pharmaceutical products and other organic compounds. The oxygen incorporated in the p-hydroxylation reaction from m-cresol is derived from water with consumption of O2.
Lee
Kyoung
K
Department of Microbiology, Changwon National University, Changwon, Kyongnam, Korea. kyounglee@changwon.ac.kr
D002733:Chlorophenols / Q000378:metabolism; D003408:Cresols / Q000378:metabolism; D049308:Dioxygenases; D048168:Escherichia coli K12 / Q000201:enzymology* / Q000235:genetics*; D006900:Hydroxylation; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D010101:Oxygen Consumption; D010105:Oxygenases / Q000235:genetics / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism*; D011549:Pseudomonas / Q000201:enzymology / Q000235:genetics; D014169:Transformation, Bacterial
D002733:Chlorophenols; D003408:Cresols; D009097:Multienzyme Complexes; D010636:Phenols; D010105:Oxygenases; D049308:Dioxygenases; C038703:naphthalene dioxygenase