Effect of 2.1 MPa and 4.1 MPa H2O2 exposure on auditory brain stem evoked potential in mice.
Brain auditory evoked potential (BAEP) in mice exposed to hyperbaric H2O2 pressure was monitored to reveal the correlation between altered synaptic transmission and hydrogen narcosis or isobaric HPNS. Inter peak latencies and wave amplitudes were selected as indices of assessment. The animals were exposed either to He-O2 or H2-O2 at 2.1 MPa and 4.1 MPa. Results showed that synaptic transmission was inhibited to various extents. The inhibition was partly due to the narcotic effect of hydrogen, which was added to the effect caused by hydrostatic pressure. On the other hand, asymmetrical reaction of each segment in the neuro-network might be responsible for the occurrence of HPNS.
Weibing
X
X
The Diving Medicine Laboratory, the NMRI of the PLA Shanghai, China.
Jun
L
L
Zheng
M
M
Fengtao
Y
Y
Hexiang
Z
Z
D000818:Animals; D003664:Decompression / Q000379:methods; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D006371:Helium / Q000008:administration & dosage / Q000494:pharmacology; D006610:High Pressure Neurological Syndrome / Q000503:physiopathology; D006859:Hydrogen / Q000008:administration & dosage / Q000494:pharmacology*; D006874:Hydrostatic Pressure; D007222:Inert Gas Narcosis / Q000503:physiopathology; D008297:Male; D051379:Mice; D010100:Oxygen / Q000008:administration & dosage / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D006371:Helium; D006859:Hydrogen; D010100:Oxygen