Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities.
Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (1), were synthesized and their structure-activity relationships were studied.
Aoyagi
Yutaka
Y
School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Hitotsuyanagi
Yukio
Y
Hasuda
Tomoyo
T
Fukaya
Haruhiko
H
Takeya
Koichi
K
Aiyama
Ritsuo
R
Matsuzaki
Takeshi
T
Hashimoto
Shusuke
S
D045744:Cell Line, Tumor; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds; D006801:Humans; D008958:Models, Molecular; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; C001899:triptolide