The role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes.
The review summarizes for the first time the current concepts of the role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes. Evolutionary concepts are developed about the origin of protein tyrosine kinases (PTK)-signaling.
Schemarova
Irina V
IV
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia. Irina@lis.mail.iephb.ru
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D006133:Growth Substances / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000031:analogs & derivatives / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology*; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism*; D018631:ras Proteins / Q000502:physiology
D006133:Growth Substances; D050791:STAT Transcription Factors; D019000:Phosphotyrosine; D014443:Tyrosine; D011494:Protein Kinases; D018631:ras Proteins