[Application of tissue microarrays for the diagnosis, prognosis and therapeutic decision making in renal cell carcinoma].
The tissue microarray technique (TMA) represents a powerful diagnostic "high-throughput" tool to analyse DNA/RNA or protein alterations in large patient cohorts in a time and cost effective way. This review focuses on the clinical application of TMA in renal cell carcinoma in modern "translational" medicine--"from bench to bedside". In particular, the advantages of TMA for diagnosis, prognosis and decisions for therapy will be considered in relation to renal cell cancer.
Merseburger
A S
AS
Abteilung für Urologie, Eberhard Karls-Universität, Tübingen. axel.merseburger@med.uni-tuebingen.de
Hennenlotter
J
J
Schilling
D
D
Sievert
K D
KD
Küfer
R
R
Kuczyk
M A
MA
D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002402:Cathepsin D / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D016612:Paraffin Embedding; D011237:Predictive Value of Tests; D011379:Prognosis; D040081:Protein Array Analysis / Q000379:methods*; D016019:Survival Analysis
D005819:Genetic Markers; D009363:Neoplasm Proteins; D002402:Cathepsin D