title: Age-associated changes of flash visual evoked potentials in dogs.
abstract: Age-associated changes of visual evoked potentials by flash stimulation (flash VEP) were evaluated in 53 beagle dogs aged from 1- to 15-year-old. Among the components of flash VEP consisted of 3 positive (P1, P2 and P3) and 2 negative (N1 and N2) peaks by 150 msec, the latency of P2 and the later peaks (N2 and P3) were significantly delayed with aging. Both amplitudes of the P2-N2 and N2-P3 also showed a significant correlation with aging. The flash VEP is considered to be an available and useful technique to evaluate not only for visual pathway, but also some disturbance of neurological functions, like as those reported in demented human.
authors.affiliation: Medicinal Safety Research Laboratories, Sankyo Co., Ltd., Fukuroi, Shizuoka 437-0065, Japan.
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Kimotsuki
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Yasuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tamahara
authors.forename: Mizuki
authors.initials: M
authors.lastname: Tomihari
authors.forename: Naoaki
authors.initials: N
authors.lastname: Matsuki
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ono
mesh_terms: D000367:Age Factors; D000818:Animals; D004285:Dogs / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D010775:Photic Stimulation