Control of acute myeloid leukemia morbidity in northwest Iran.
BACKGROUND
To investigate protocols of remission induction therapy for prevention of morbidity of acute myeloid leukemia.


METHODS
The responses of 150 patients to "2+5" and "3+7" protocols during 1996-2003 were assessed and analyzed with the Chi-Square method.


RESULTS
Complete remission was observed in 30% of cases treated with 2 days of daunorubicin and 5 days of cytarabine (2+5 regimen). Remission was increased to 52.5% when patients were treated with 3+7 regimens with the same drugs. Partial remission resulted in 25 and 10 percent of cases, respectively.


CONCLUSIONS
As in previous studies the 3+7 regimen was demonstrated to be more effective than the 2+5 regimen in our hospital (p=0.0009).
Eivazi-Ziaei
Jamal
J
Ghazi Hematology Oncology Research Department, Tabriz University of Medical Sciences, Iran 51665-139. jeziaei@yahoo.com
D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003561:Cytarabine / Q000008:administration & dosage*; D003630:Daunorubicin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D007492:Iran; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008875:Middle Aged; D012074:Remission Induction; D012189:Retrospective Studies
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D003630:Daunorubicin