title: Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.
abstract: A 54-year-old man received combination chemotherapy with nedaplatin and irinotecan as salvage chemotherapy for refractory non-seminomatous testicular cancer. The patient developed abdominal pain and high fever on Day 21 after the initiation of chemotherapy. Computed tomography revealed thickening of the terminal ileum wall and paralytic ileus. The patient recovered with intensive supportive management including broad-spectrum antibiotics, bowel rest with gastric intubation and intravenous gamma-globulin. Neutropenic colitis has been thought to be a serious gastrointestinal complication associated with chemotherapy for hematological malignancy. The mortality rate is as high as 21-48% according to a recent review. The present case indicates that the neutropenic colitis can occur under neutropenic conditions induced by the standard-dose chemotherapy for solid cancer.
authors.affiliation: Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. tach-tech-voice@mvb.biglobe.ne.jp
authors.forename: Ei-Ichiro
authors.initials: E
authors.lastname: Takaoka
authors.forename: Koji
authors.initials: K
authors.lastname: Kawai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ando
authors.forename: Toru
authors.initials: T
authors.lastname: Shimazui
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Akaza
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives; D006063:Chorionic Gonadotropin / Q000097:blood; D004334:Drug Administration Schedule; D044504:Enterocolitis, Neutropenic / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects; D011860:Radiography, Abdominal; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D006063:Chorionic Gonadotropin; D009944:Organoplatinum Compounds; D005719:gamma-Globulins; D000077146:Irinotecan; C053989:nedaplatin; D002166:Camptothecin