title: Daptomycin-rifampin for a recurrent MRSA joint infection unresponsive to vancomycin-based therapy.
abstract: A 54-y-old morbidly obese male presented with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia secondary to chronic right hip arthroplasty infection. Bacteremia persisted despite prolonged vancomycin-based therapy (MIC < or = 1 microg/ml) and prosthetic removal. Adding daptomycin-rifampin resolved bacteremia within 48 h; hip cultures remained negative post-discharge. This case describes alternative treatment for chronic MRSA infections.
authors.affiliation: Ocala Regional Medical Center, Ocala, Florida, USA. dorchak2003@yahoo.com
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Burns
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology*; D017576:Daptomycin / Q000627:therapeutic use; D004868:Equipment Failure; D006801:Humans; D007592:Joint Diseases / Q000150:complications*; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin; D012293:Rifampin