Sirolimus: a new immunosuppressant.
Though organ transplantation has evolved in many a ways over the years, it is not without the disadvantage of causing rejections. Cyclosporin, azathioprine and corticosteroids are time tested and efficacious; however each is accompanied with its own array of disadvantages. Sirolimus is a relatively new immunosuppressant isolated from a macrolide antibiotic. It may have a beneficial role in prophylaxis of rejection as well as treatment of refractory rejection. It also has antifungal, antitumor and anti-smooth muscle proliferative roles.
Mukherjee
T
T
PD Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai 400 016, India.
Shah
B V
BV
D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D020123:Sirolimus / Q000737:chemistry / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D020123:Sirolimus