[The relationship between 99mTc-MIBI scintimammography of breast cancer and multidrug-resistant proteins].
OBJECTIVE
To evaluate the relationship between the clearance rate of technetium-99m methoxyisobutylisonitrile ((99m)Tc-MIBI) in scintimammography and multidrug-resistant proteins expression in breast cancer tissues.


METHODS
Seventy-six patients with breast cancer underwent (99m)Tc-MIBI scintimammography before treatment, and static planar images were taken at 10 min and 180 min after scintimammography. The clearance rate of (99m)Tc-MIBI was calculated in each patient. Immunohistochemical analysis was performed on pathological specimens of the 76 breast tumors to determine the expression of P-glycoprotein (P-gp), glutathione S-transferase Pi (GST-pi) and topoisomerase II (Topo II).


RESULTS
The clearance rate was significantly higher in 36 patients with positive P-gp expression when compared with that in 40 patients with negative P-gp expression. There was no significant relationship between GST-pi, Topo II and the clearance rate of (99m)Tc-MIBI.


CONCLUSIONS
The clearance rate of (99m)Tc-MIBI in breast imaging may be used to evaluate the P-gp level in breast cancers.
Cui
Shu-de
SD
Department of Breast Diseases, Henan Tumor Hospital, Zhengzhou 450008, China.
Liu
Zhen-zhen
ZZ
Liu
Hui
H
Li
Lian-fang
LF
Yang
Hui
H
Li
Wen-liang
WL
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000032:analysis; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000000981:diagnostic imaging*; D004250:DNA Topoisomerases, Type II / Q000032:analysis; D018432:Drug Resistance, Multiple; D005260:Female; D051549:Glutathione S-Transferase pi / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000032:analysis*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
D018435:ATP Binding Cassette Transporter, Subfamily B; D004250:DNA Topoisomerases, Type II; D051549:Glutathione S-Transferase pi; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi