Redox kinetics of adriamycin adsorbed on the surface of graphite and mercury electrodes.
Kinetics of the surface redox reactions of adriamycin (doxorubicin hydrochloride) adsorbed on paraffin-impregnated graphite electrode (PIGE) and on mercury electrode is measured by square-wave voltammetry. In 0.9 mol/L KNO3 buffered to pH 4.65, the standard electrode reaction rate constants of the first quinone/hydroquinone redox couple (see Scheme 2) on PIGE and mercury are k(s1)=49+/-12 s(-1) and k(s1)=147+/-36 s(-1), respectively. Under the same conditions, the standard rate constant of the second redox couple on the PIGE is smaller than 4 s(-1) and the electron transfer coefficient of the reduction is alpha2=0.35.
Komorsky-Lovrić
Sebojka
S
Center for Marine and Environmental Research Ruder Bosković Institute, P.O. Box 180 10002, Zagreb, Croatia. slovric@rudjer.irb.hr
D000327:Adsorption; D004317:Doxorubicin / Q000737:chemistry*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D007700:Kinetics; D008628:Mercury / Q000737:chemistry*; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013499:Surface Properties
D006108:Graphite; D004317:Doxorubicin; D008628:Mercury