title: Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives.
abstract: In order to develop spin traps with an optimal ratio between hydrophilic and lipophilic properties, low toxicity, and high stability of spin adducts (especially with superoxide radicals), several EMPO-derived spin traps have recently been synthesized forming more stable superoxide adducts (t(1/2) > 20 min) than DMPO or DEPMPO. In this study, ESR-, 1H-, and 13C-NMR data of several phenyl- or n-pentyl-substituted EMPO derivatives are presented with full signal assignment. Methyl groups at position 3 or 4 stabilized the superoxide adducts considerably. Spin adducts from other oxygen- and carbon-centered radicals (e.g., derived from methanol or linoleic acid hydroperoxide) are also described.
authors.affiliation: Research Institute of Biochemical Pharmacology and Molecular Toxicology, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria. Klaus.Stolze@vu-wien.ac.at
authors.forename: Klaus
authors.initials: K
authors.lastname: Stolze
authors.forename: Natascha
authors.initials: N
authors.lastname: Rohr-Udilova
authors.forename: Thomas
authors.initials: T
authors.lastname: Rosenau
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofinger
authors.forename: Daniel
authors.initials: D
authors.lastname: Kolarich
authors.forename: Hans
authors.initials: H
authors.lastname: Nohl
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002247:Carbon Isotopes; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D019097:Spin Trapping
chemical_list: C406273:2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide; D002247:Carbon Isotopes; D005609:Free Radicals; D011758:Pyrroles; D002244:Carbon; D010100:Oxygen