Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss.
A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1beta levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.
Oshima
Shigeki
S
Department of Orthopaedics, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
Onodera
Shin
S
Amizuka
Norio
N
Li
Minqi
M
Irie
Kazuharu
K
Watanabe
Satoshi
S
Koyama
Yoshikazu
Y
Nishihira
Jun
J
Yasuda
Kazunori
K
Minami
Akio
A
D000818:Animals; D001842:Bone and Bones / Q000473:pathology; D002452:Cell Count; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000209:etiology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D008263:Macrophage Migration-Inhibitory Factors / Q000172:deficiency* / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D010010:Osteoclasts / Q000473:pathology; D010024:Osteoporosis / Q000209:etiology; D015663:Osteoporosis, Postmenopausal / Q000209:etiology*; D010052:Ovariectomy / Q000009:adverse effects*
D007375:Interleukin-1; D008263:Macrophage Migration-Inhibitory Factors