title: Regulatory dendritic cells modulate immune responses via induction of T-cell apoptotic death.
abstract: We describe a regulatory lymphoid dendritic cell (LDC) population propagated from mouse liver nonparenchymal cells (NPC) in IL-3 and anti-CD40 monoclonal antibody that are phenotypically mature, and induce T-cell hyporesponsiveness by promoting T-cell apoptotic death, which is partially caspase-dependent, but is unlikely to be mediated by soluble factor(s). In vivo administration of liver LDC significantly prolonged the survival of vascularized cardiac allografts in an alloantigen-specific manner. This is associated with enhanced T-cell death in secondary lymphoid organs.
authors.affiliation: Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liang
authors.forename: Zongyou
authors.initials: Z
authors.lastname: Chen
authors.forename: John J
authors.initials: JJ
authors.lastname: Fung
authors.forename: Shiguang
authors.initials: S
authors.lastname: Qian
authors.forename: Lina
authors.initials: L
authors.lastname: Lu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D018929:Cell Culture Techniques; D003713:Dendritic Cells / Q000502:physiology*; D006085:Graft Survival / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology*; D020287:In Situ Nick-End Labeling; D017493:Leukocyte Common Antigens / Q000502:physiology*; D008099:Liver / Q000166:cytology* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D017493:Leukocyte Common Antigens