Tolloid gets Sizzled competing with Chordin.
The enigma of Sizzled, a secreted Frizzled-related protein, has been resolved in a recent study from the De Robertis lab ( [in the January 13 issue of Cell]). Sizzled, although homologous to other Wnt antagonists, does not function as such, nor does it function within a Wnt signaling pathway. Remarkably it functions as an antagonist of BMP signaling, competing with Chordin for binding to its inhibitor a Tolloid-related metalloprotease. This competition protects Chordin from cleavage, thus allowing it to bind and limit BMP signaling.
Mullins
Mary C
MC
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
D000818:Animals; D001667:Binding, Competitive; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D045726:Metalloproteases / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction; D055394:Tolloid-Like Metalloproteinases; D014981:Xenopus; D029867:Xenopus Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D029867:Xenopus Proteins; C109976:szl protein, Xenopus; C054234:chordin; D045726:Metalloproteases; D055394:Tolloid-Like Metalloproteinases