title: The role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes.
abstract: The review summarizes for the first time the current concepts of the role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes. Evolutionary concepts are developed about the origin of protein tyrosine kinases (PTK)-signaling.
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia. Irina@lis.mail.iephb.ru
authors.forename: Irina V
authors.initials: IV
authors.lastname: Schemarova
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D006133:Growth Substances / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000031:analogs & derivatives / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology*; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism*; D018631:ras Proteins / Q000502:physiology
chemical_list: D006133:Growth Substances; D050791:STAT Transcription Factors; D019000:Phosphotyrosine; D014443:Tyrosine; D011494:Protein Kinases; D018631:ras Proteins