title: Synthesis of 9-[1-(substituted)-2-(phosphonomethoxy)ethyl]adenine derivatives as possible antiviral agents.
abstract: Various C-1'-substituted acyclic N9 adenine nucleosides were prepared from 9-[(1-hydroxymethyl)(3-monomethoxytrityloxy)propyl]-N6-monomethoxytrityladenine. The hydroxymethyl was modified to the phosphonomethoxy derivative, and the 3-monomethoxytrityloxy was converted to hydroxyl, methoxy, azido, and amino. Other substituents, such as ethyl and ea-hydroxyethyl were also prepared. The resulting phosphonomethoxy derivatives were converted to prodrugs.
authors.affiliation: BioCryst Pharmaceuticals, Inc., Birmingham, Alabama 35244, USA.
authors.forename: Minwan
authors.initials: M
authors.lastname: Wu
authors.forename: Yahya
authors.initials: Y
authors.lastname: El-Kattan
authors.forename: Tsu-Hsing
authors.initials: TH
authors.lastname: Lin
authors.forename: Ajit
authors.initials: A
authors.lastname: Ghosh
authors.forename: V Satish
authors.initials: VS
authors.lastname: Kumar
authors.forename: Pravin L
authors.initials: PL
authors.lastname: Kotian
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Cheng
authors.forename: Shanta
authors.initials: S
authors.lastname: Bantia
authors.forename: Yarlagadda S
authors.initials: YS
authors.lastname: Babu
authors.forename: Pooran
authors.initials: P
authors.lastname: Chand
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D011355:Prodrugs; D000225:Adenine