title: [Clinical study on treatment of cirrhosis by different dosages of salvia injection].
abstract: OBJECTIVE
  To find the optimal dosage of salvia injection (SI) on treating cirrhosis with hepatitis B virus (HBV).
  
  
  METHODS
  120 patients, whose diagnosis was confirmed as cirrhosis with HBV and differentiated by TCM typing as blood stasis blocking collaterals type, were divide into two groups. one was compensatory cirrhosis group (A group, 60 patients), another was decompensated cirrhosis group (B group, 60 patients). In each group, patients were selected and randomly divided by lottery method into the large (24 ml), middle (16 ml) and small dose (8 ml) of SI treated groups and control group. The primary treatment was same in all patients. The course of treatment was 60 days. The clinical symptoms and signs, and liver functional indexes as ALT and TBil, and liver fibrosis indexesas procollagen type III (PCIII), collagen type IV (CIV) and hyaluronic acid (HA), were measured before and after treatment.
  
  
  RESULTS
  Different dosages of SI all could improve the clinical symptoms and decline the level of ALT, TBil, PC III, CIV and HA (P < 0. 05). Treatment of large dosages SI showed the best efficacy, superior to that of middle and small dosage of SI (P < 0.05), but no significant difference was found between the efficacy of the latter two (P > 0.05). The efficacy of SI to compensatory cirrhosis group was better than that of decompensated cirrhosis group (P < 0.05).
  
  
  CONCLUSIONS
  The large dosage (24 ml) of SI have the best effect to treat the cirrhosis with BHV, particularly to patients with compensated cirrhosis.
authors.affiliation: The First Hospital of Xi' an Jiaotong University, Xi' an 710061.
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Genquan
authors.initials: G
authors.lastname: Qiu
authors.forename: Yingren
authors.initials: Y
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Liu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal