The potential of stem cell therapies for neurological diseases.
As a novel neurotherapeutic strategy, stem cell transplantation has received considerable attention, yet little of this attention has been devoted to the probabilities of success of stem cell therapies for specific neurological disorders. Given the complexities of the cellular organization of the nervous system and the manner in which it is assembled during development, it is unlikely that a cellular replacement strategy will succeed for any but the simplest of neurological disorders in the near future. A general strategy for stem cell transplantation to prevent or minimize neurological disorders is much more likely to succeed. Two broad categories of neurological disease, inherited metabolic disorders and invasive brain tumors, are among the most likely candidates.
Schwartz
Philip H
PH
Children's Hospital of Orange County Research Institute, National Human Neural Stem Cell Resource PI, Human Embryonic Stem Cell Culture Training Course, Orange, CA 92868-3874, USA. pschwartz@choc.org
D000818:Animals; D005104:Expert Testimony; D006801:Humans; D009422:Nervous System Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*