Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging.
It was recently reported by Kurosu et al. that overexpression of Klotho, a newly discovered hormone, extends longevity of mice. Because Klotho induces IGF-1 and insulin resistance, these findings appear to contradict previous evidence for increased life span of dwarf mice with reduced IGF-1 and insulin levels and enhanced insulin sensitivity. However, activation of signaling molecules downstream from IGF-1 and insulin receptors is reduced in both Klotho and dwarf mice, suggesting common mechanisms of delayed aging.
Bartke
Andrzej
A
Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL 62794-9628, USA. abartke@siumed.edu
D000375:Aging / Q000502:physiology*; D000818:Animals; D005260:Female; D005966:Glucuronidase / Q000235:genetics*; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D000090265:Klotho Proteins; D008136:Longevity / Q000235:genetics* / Q000502:physiology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000502:physiology*
D007328:Insulin; D007334:Insulin-Like Growth Factor I; D005966:Glucuronidase; D000090265:Klotho Proteins