Mechanisms of immune-mediated skin diseases: an overview.
The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments.These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or autoantibody dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-mediated disorders. In some instances (e.g., psoriasis and atopic dermatitis) genetic predisposition can affect also the capacity of keratinocytes to initiate or perpetuate inflammatory responses. A more precise understanding of the molecular and cellular mechanisms underlying each disorder may allow the identification of novel targets for more effective therapeutic strategies.
Beissert
S
S
Department of Dermatology, University of Münster, Münster, Germany.
Cavazzana
I
I
Mascia
F
F
Meroni
P
P
Pastore
S
S
Tessari
G
G
Girolomoni
G
G
D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology; D002908:Chronic Disease; D003872:Dermatitis / Q000276:immunology; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D019013:CD40 Antigens; D023201:CD40 Ligand