title: Preproghrelin Leu72Met polymorphism in obese Korean children.
abstract: Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Dae-Sun
authors.initials: DS
authors.lastname: Jo
authors.forename: Se-Lim
authors.initials: SL
authors.lastname: Kim
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Pyoung Han
authors.initials: PH
authors.lastname: Hwang
authors.forename: Kee-Hyoung
authors.initials: KH
authors.lastname: Lee
authors.forename: Dae-Yeol
authors.initials: DY
authors.lastname: Lee
mesh_terms: D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006580:Genetic Carrier Screening; D054439:Ghrelin; D006801:Humans; D007723:Korea; D007930:Leucine / Q000235:genetics*; D008297:Male; D008715:Methionine / Q000235:genetics*; D009037:Motilin / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
chemical_list: D054439:Ghrelin; D014280:Triglycerides; D009037:Motilin; D002784:Cholesterol; D008715:Methionine; D007930:Leucine