title: Massive creatine kinase elevations with quetiapine: report of two cases.
abstract: Massive elevations of serum creatine kinase (CK) can occur in a significant number of patients treated with neuroleptics in the absence of neuroleptic malignant syndrome (NMS). We report two cases of CK-elevations associated with quetiapine treatment, which disappeared after drug discontinuation. To our knowledge, case number one is the first case of quetiapine-induced CK elevation in a neuroleptic-naïve patient. We thus suggest CK assessment when myalgia occurs with neuroleptic treatment.
authors.forename: J P
authors.initials: JP
authors.lastname: Klein
authors.forename: U
authors.initials: U
authors.lastname: Fiedler
authors.forename: H
authors.initials: H
authors.lastname: Appel
authors.forename: A
authors.initials: A
authors.lastname: Quante
authors.forename: M C
authors.initials: MC
authors.lastname: Jockers-Scherübl
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D003987:Dibenzothiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008803:Mianserin / Q000031:analogs & derivatives / Q000627:therapeutic use; D000078785:Mirtazapine; D000077152:Olanzapine; D010146:Pain / Q000209:etiology; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy; D000069348:Quetiapine Fumarate
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D008803:Mianserin; D000069348:Quetiapine Fumarate; D000078785:Mirtazapine; D003402:Creatine Kinase; D003024:Clozapine; D000077152:Olanzapine