title: Bacterial biofilm inhibitors from Diospyros dendo.
abstract: One new (1) and four known (2-5) ursene triterpenes with potent inhibition of the formation of the bacterial biofilm Pseudomonas aeruginosa PA01 were obtained from Diospyros dendo using a high-throughput natural products chemistry procedure. These compounds were isolated as mass-limited samples. The miniaturization of the structure elucidation and dereplication was performed primarily utilizing a capillary-scale NMR probe.
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 11199 Sorrento Valley Road, Suite H, San Diego, California 92121, USA. jhu@sequoiasciences.com
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
authors.forename: Eliane
authors.initials: E
authors.lastname: Garo
authors.forename: Matt G
authors.initials: MG
authors.lastname: Goering
authors.forename: Mark
authors.initials: M
authors.lastname: Pasmore
authors.forename: Hye-Dong
authors.initials: HD
authors.lastname: Yoo
authors.forename: Tim
authors.initials: T
authors.lastname: Esser
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sestrich
authors.forename: Peadar A
authors.initials: PA
authors.lastname: Cremin
authors.forename: Grayson W
authors.initials: GW
authors.lastname: Hough
authors.forename: Peter
authors.initials: P
authors.lastname: Perrone
authors.forename: Yin-Shi L
authors.initials: YS
authors.lastname: Lee
authors.forename: Ngoc-Tram
authors.initials: NT
authors.lastname: Le
authors.forename: Mark
authors.initials: M
authors.lastname: O'Neil-Johnson
authors.forename: John W
authors.initials: JW
authors.lastname: Costerton
authors.forename: Gary R
authors.initials: GR
authors.lastname: Eldridge
mesh_terms: D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D029788:Diospyros / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C508541:3-O-cis-p-coumaroyl-20-hydroxy-12-ursen-28-oic acid; D014315:Triterpenes