What about chemoprevention for melanoma?
OBJECTIVE
This paper aims to critically review the potential for a chemoprevention strategy in melanoma, and to discuss new data on candidate chemoprevention agents, as chemoprevention has been suggested as an unexplored approach in melanoma.


RESULTS
A strong scientific rationale, established long-term safety of candidate agents, and a systematic step-wise approach to chemoprevention agent development are all critical for melanoma chemoprevention research. Among potential agents, the lipid-lowering drugs, the statins, satisfy these prerequisites.


CONCLUSIONS
Chemoprevention of cutaneous melanoma can become a valid strategy complementing current prevention approaches, as long as these important prerequisites are taken into consideration.
Demierre
Marie-France
MF
Skin Oncology Program, Department of Dermatology, Boston University School of Medicine, MA 02118, USA. mariefrance.demierre@bmc.org
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D006801:Humans; D008545:Melanoma / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000517:prevention & control*
D016588:Anticarcinogenic Agents