Building signaling complexes at the membrane.
Cell membranes, the plasma membrane in particular, serve as the hub of various cellular signaling networks. In response to receptor activation, many cytosolic proteins are reversibly recruited to membranes to form dynamic signaling complexes. Membranes provide a unique microenvironment in which the formation of signaling complexes can be exquisitely modulated by the fine interplay between protein-protein and lipid-protein interactions.
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Wonhwa
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Department of Chemistry (M/C 111), 845 West Taylor Street, University of Illinois at Chicago, Chicago, IL 60607-7061, USA. wcho@uic.edu
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000502:physiology; D000818:Animals; D006801:Humans; D046911:Macromolecular Substances; D008563:Membrane Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D055672:Static Electricity
D048868:Adaptor Proteins, Signal Transducing; D046911:Macromolecular Substances; D008563:Membrane Lipids; D008565:Membrane Proteins; C080321:STE5 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins