title: [Essential thrombocythemia associated with incomplete type intestinal Behçet disease during hydroxyurea treatment].
abstract: A 77-year-old man was diagnosed as having essential thrombocythemia in 1992. Treatment with hydroxyurea was started in 1997, which stabilized the platelet count. The patient then suffered from pharyngalgia and rhinitis with a high fever, immediately after which he developed tarry stools and anemia and was admitted to our hospital. The physical examination revealed splenomegaly, oral aphthous ulcers, genital ulcers and skin lesions on the lower limbs. His hematological and biochemical tests revealed anemia and increased level of C-reactive protein. He also had an HLA-B51 phenotype. The findings of gastro-intestinal and colon fiberoscopy showed a duodenal ulcer and multiple ulcers on ascending colon. He was thus diagnosed as having intestinal tract-type Behçet disease. After withdrawal of the hydroxyurea administration, the intestinal ulcers, oral aphthous ulcers and genital ulcers improved.
authors.affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
authors.forename: Kageaki
authors.initials: K
authors.lastname: Kuribayashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Iyama
authors.forename: Akihito
authors.initials: A
authors.lastname: Fujimi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Aya
authors.initials: A
authors.lastname: Ueno
authors.forename: Shouhei
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Satoh
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Okamoto
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000368:Aged; D001528:Behcet Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D015235:HLA-B Antigens / Q000097:blood; D059949:HLA-B51 Antigen; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008297:Male; D013920:Thrombocythemia, Essential / Q000188:drug therapy*
chemical_list: D015415:Biomarkers; D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D006918:Hydroxyurea