Intra-arterial chemotherapy for liver metastases from colorectal cancer.
The aim was to investigate whether intra-arterial infusion of chemotherapy improves response to treatment in unresectable liver metastases from colorectal cancer. We treated 14 patients (pts) with intra-arterial chemotherapy. Arterial catheters were placed via percutaneous access. Treatment schedule was: 5-FU and mitomycin-C on day 1 every 21 days. Six pts also received from day 3 for 5 days, a continuous intra-arterial 24-hr infusion of interleukin-2 (IL-2). We had only one case of toxicity drug-related > grade 2 (neutropenia). We observed 2 partial response (PR) and 5 stable disease (SD). Median time to disease progression (TTP) and median survival (OS) were, respectively 4 and 15 months.
Milandri
M
M
UO Oncologia Medica, Ospedale Morgagni-Pierantoni, Forlì.
Calzolari
F
F
Passardi
A
A
Ridolfi
R
R
Tison
C
C
Giampalma
E
E
Golfieri
R
R
Ridolfi
L
L
Mura
G
G
Vagliasindi
A
A
Fra Marini
M
M
Verdecchia
G M
GM
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents