title: Substituted coumarins as potent 5-lipoxygenase inhibitors.
abstract: Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Hwy, Kirkland, Que., Canada H9H 3L1. erich_grimm@merck.com
authors.forename: Erich L
authors.initials: EL
authors.lastname: Grimm
authors.forename: Christine
authors.initials: C
authors.lastname: Brideau
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chauret
authors.forename: Chi-Chung
authors.initials: CC
authors.lastname: Chan
authors.forename: Daniel
authors.initials: D
authors.lastname: Delorme
authors.forename: Yves
authors.initials: Y
authors.lastname: Ducharme
authors.forename: Diane
authors.initials: D
authors.lastname: Ethier
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Falgueyret
authors.forename: Richard W
authors.initials: RW
authors.lastname: Friesen
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Guay
authors.forename: Pierre
authors.initials: P
authors.lastname: Hamel
authors.forename: Denis
authors.initials: D
authors.lastname: Riendeau
authors.forename: Chantal
authors.initials: C
authors.lastname: Soucy-Breau
authors.forename: Philip
authors.initials: P
authors.lastname: Tagari
authors.forename: Yves
authors.initials: Y
authors.lastname: Girard
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D016859:Lipoxygenase Inhibitors; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D003374:Coumarins; D004791:Enzyme Inhibitors; D016859:Lipoxygenase Inhibitors