Application of the regression of offspring on mid-parent method to detect associations between single-nucleotide polymorphisms and the beta 2 electroencephalogram phenotype in the COGA data.
The beta 2 electroencephalogram (EEG) phenotype is used as a quantitative measure related to alcoholism, and evidence of linkage and association has previously been reported in the Collaborative Study on the Genetics of Alcoholism data. In this study, associations between the beta 2 EEG phenotype and single nucleotide polymorphisms from whole-genome Illumina and Affymetrix panels were investigated with the regression of offspring on mid-parent method to identify significant genetic effects and to estimate their heritability. Separate regressions on father and mother were performed to identify parent-specific effects. Estimates of the heritability of the beta 2 EEG phenotype were 0.68 +/- 0.12 and 0.52 +/- 0.07 based on father-offspring and mother-offspring pairs, respectively. Significant associations at the 0.0005 level, some of which were parent-specific, were found on chromosomes 1, 2, 5, 6, 7, 8, 11, 12, 15, 16, 17, 18, and 19 with heritability attributable to each SNP ranging from 0.01 to 8%.
Roy-Gagnon
Marie-Hélène
MH
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr, Baltimore, Maryland 21224, USA. mhrg@mail.nih.gov
Mathias
Rasika A
RA
Wilson
Alexander F
AF
D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D003299:Cooperative Behavior; D030541:Databases, Genetic; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010290:Parents; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis; D044465:White People / Q000235:genetics