The origin of epithelial neoplasms after allogeneic stem cell transplantation.
We analyzed five women, who have developed epithelial neoplasms after sex-mismatched stem cell transplants. Using in situ hybridization for sex chromosome-specific DNA probes and immunohistochemistry we identified the origin of the tumor cells. We conclude that none of the non-hematologic malignancies was of donor origin.
Smith
Mary J
MJ
van Cleef
Patricia H J
PH
Schattenberg
Anton V M B
AV
van Krieken
Johan H J M
JH
D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000209:etiology* / Q000473:pathology; D014019:Tissue Donors; D014184:Transplantation, Homologous