[The mechanism of bone resorption in chronic inflammation of periodontal disease].
Periodontal disease is caused by infections with oral periodontitis-associated microorganisms. Virulence factors like lipopolysaccharide (LPS) from those microorganisms initiate host immune response and gingival chronic inflammation. As a result, elevated receptor activator of NF-kappaB ligand (RANKL) expression stimulates alveolar bone resorption followed by loss of teeth.
Kikuchi
Takeshi
T
Department of Periodontology, School of Dentistry, Aichi-Gakuin University.
Mitani
Akio
A
Noguchi
Toshihide
T
D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology* / Q000628:therapy; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D010510:Periodontal Diseases / Q000503:physiopathology*; D037521:Virulence Factors / Q000502:physiology
D008070:Lipopolysaccharides; D037521:Virulence Factors