title: [Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer].
abstract: OBJECTIVE
  To investigate the association between methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of lung cancer.
  
  
  METHODS
  Totally 505 cases with lung cancer and 500 frequency-matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism methods. The odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression model. Haplotype frequency was estimated using EH software.
  
  
  RESULTS
  The frequency of the MTHFR C677T allele in cases was significantly higher than that in controls (53.5% vs 44.9%, P < 0.001). Compared with the 677CC genotype, the 677CT and 677TT genotypes were associated with increased risk of lung cancer, with the OR being 1.43 (95% CI, 1.04-1.95) and 2.40 (95% CI, 1.61-3.59), respectively. In addition, a significant difference in the distribution of haplotype frequencies between cases and controls was observed.
  
  
  CONCLUSIONS
  Functional polymorphism in MTHFR is associated with increased risk of lung cancer in Chinese population.
authors.affiliation: Department of Etiology and Carcinogenesis, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Miao
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Shi-ning
authors.initials: SN
authors.lastname: Qu
authors.forename: Tong
authors.initials: T
authors.lastname: Sun
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Zhou
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)