Development of a polar-embedded stationary phase with unique properties.
This paper describes a new polar-embedded stationary phase that contains an internal sulfonamide functional group coupled with an ether linkage. The synthesis involves functionalization of spherical silica particles with ligands prepared in a multi-step synthesis. The resulting material contains 16.5% carbon, corresponding to a ligand coverage of 2.4mumol/m(2). Chromatographic evaluations indicates that the new stationary phase exhibits lower polarity than any other polar-embedded packings investigated, with additional features such as low silanol activity, excellent compatibility with 100% aqueous mobile phases, higher shape selectivity for polycyclic aromatic hydrocarbons, and strong affinity to nitro-containing compounds.
Liu
Xiaodong
X
Dionex Corporation, Sunnyvale, CA 94088, USA. xiaodong.liu@dionex.com
Bordunov
Andrei
A
Tracy
Mark
M
Slingsby
Rosanne
R
Avdalovic
Nebojsa
N
Pohl
Christopher
C
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009574:Nitro Compounds / Q000302:isolation & purification*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
D009574:Nitro Compounds; D013449:Sulfonamides