title: Methods to test for association between a disease and a multi-allelic marker applied to a candidate region.
abstract: We report the analysis results of the Genetic Analysis Workshop 14 simulated microsatellite marker dataset, using replicate 50 from the Danacaa population. We applied several methods for association analysis of multi-allelic markers to case-control data to study the association between Kofendrerd Personality Disorder and multi-allelic markers in a candidate region previously identified by the linkage analysis. Evidence for association was found for marker D03S0127 (p < 0.01). The analyses were done without any prior knowledge of the answers.
authors.affiliation: Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, P.O. Box 9604, 2300RC Leiden, The Netherlands. r.elgalta@lumc.nl
authors.forename: Rachid
authors.initials: R
authors.lastname: El Galta
authors.forename: Li
authors.initials: L
authors.lastname: Hsu
authors.forename: Jeanine J
authors.initials: JJ
authors.lastname: Houwing-Duistermaat
mesh_terms: D000483:Alleles; D056426:Genetic Loci / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans
chemical_list: D005819:Genetic Markers