Store-operated Ca2+ channel in renal microcirculation and glomeruli.
Store-operated Ca2+ channel (SOC) is defined as a channel that opens in response to depletion of the internal Ca2+ stores. During the last decade, many investigators have made a great effort to identify and characterize SOC, and to evaluate its physiologic function and pathophysiologic relevance in a variety of cell lines, primary cultures, and native tissues. To date, accumulating evidence has demonstrated that SOC is an essential Ca2+ entry mechanism in vascular smooth-muscle cells of renal microvasculature and glomerular mesangial cells, both of which tightly control glomerular hemodynamics and filtration. Store-operated Ca2+, combined with other types of Ca2+ entry channels, constitutes a profile of Ca2+ changes in response to physiologic vasoconstrictors and, thereby, regulates renal microcirculation and mesangial function. In addition, SOC is associated with altered Ca2+ signaling occurring in diseased kidneys, such as diabetic nephropathy. Although the gating mechanism and molecular identity of SOC are still enigmatic and may be cell-type and tissue specific, data from several independent groups suggest that protein kinase C plays an important role in SOC activation and that certain isoforms of canonical transient receptor potential (TRPC) proteins are candidates of SOC in renal microvessels and mesangial cells.
Ma
Rong
R
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA. rma@hsc.unt.edu
Du
Juan
J
Sours
Sherry
S
Ding
Min
M
D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D007678:Kidney Glomerulus / Q000166:cytology / Q000378:metabolism*; D008833:Microcirculation; D012079:Renal Circulation; D050052:TRPC Cation Channels / Q000378:metabolism
D015220:Calcium Channels; D050052:TRPC Cation Channels; D002118:Calcium