Aponeocarzinostatin--a superior drug carrier exhibiting unusually high endurance against denaturants.
The enediyne antitumor antibiotic chromoproteins are very potent in causing DNA damages. During the drug delivery time course, the stability of the carrier protein becomes an important concern. To simulate conceivably offensive environment in biological contexts, such as cell membrane, we studied structural endurance of aponeocarzinostatin against several denaturants by circular dichroism and nuclear magnetic resonance spectroscopy. For comparison, we also examined proteins known to be stable and similar in size to aponeocarzinostatin. The results highlight the unusual structural stability of aponeocarzinostatin against chemical denaturants, suggesting the potential of aponeocarzinostatin as an inherently superior carrier in drug delivery systems.
Sudhahar
Christopher G
CG
Department of Chemistry, National Chung Hsing University, Taichung, Taiwan, ROC.
Chin
Der-Hang
DH
D001059:Apoproteins / Q000737:chemistry* / Q000494:pharmacology; D002942:Circular Dichroism; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009930:Organic Chemicals / Q000737:chemistry; D011487:Protein Conformation / Q000187:drug effects; D011489:Protein Denaturation; D009353:Zinostatin / Q000737:chemistry* / Q000494:pharmacology
D001059:Apoproteins; D004337:Drug Carriers; D009930:Organic Chemicals; C052401:aponeocarzinostatin; D009353:Zinostatin