title: [Invasive multisystemic aspergillosis in an immunocompetent child: case report].
abstract: Invasive aspergillosis is a severe disease, with an increased incidence in last decades. It occurs mainly in immunocompromised patients and rarely affects immunocompetent hosts. We describe a previously healthy 8 -year-old boy who acquired an invasive aspergillosis of abdominal origin associated with an opened laparotomy; within three weeks the patient progressed to a multiple organic failure syndrome and died despite amphotericin B deoxycolate plus voriconazole treatment and aggressive surgical debridement. Necropsy revealed multiple parenchyma involvement with characteristic findings of angioinvasive aspergillosis. Invasive aspergillosis must be considered an emergent infection in critical pediatric patients, including previously immunocompetent hosts; it is associated with high mortality despite adequate and opportune therapy.
authors.affiliation: Area de Cuidados Críticos, Unidad de Gestión Clínica del Niño, Hospital Padre Hurtado. adonoso@hurtadohosp.cl
authors.forename: Alejandro
authors.initials: A
authors.lastname: Donoso F
authors.forename: Jorge
authors.initials: J
authors.lastname: Camacho A
authors.forename: Pedro
authors.initials: P
authors.lastname: Alarcón L
authors.forename: Pablo
authors.initials: P
authors.lastname: Cruces R
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D002648:Child; D003840:Deoxycholic Acid / Q000627:therapeutic use; D004338:Drug Combinations; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D011743:Pyrimidines; D014230:Triazoles; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D065819:Voriconazole