Granulocyte apoptosis in the pathogenesis and resolution of lung disease.
Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.
Bianchi
Stephen M
SM
Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K.
Dockrell
David H
DH
Renshaw
Stephen A
SA
Sabroe
Ian
I
Whyte
Moira K B
MK
D017209:Apoptosis; D002470:Cell Survival / Q000502:physiology; D006098:Granulocytes / Q000473:pathology* / Q000502:physiology; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology*; D012130:Respiratory Hypersensitivity / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology