title: Microwave-enhanced synthesis of new (-)-steganacin and (-)-steganone aza analogues.
abstract: [reaction: see text]. A novel, microwave-enhanced, highly efficient protocol for the synthesis of hitherto unknown (-)-steganacin and (-)-steganone 7-aza analogues containing a 1,2,3-triazole ring has been presented. Microwave irradiation was found to be highly beneficial in promoting the Suzuki reaction and the 1,3-dipolar cycloaddition reaction to generate the highly strained medium-sized ring system of the title molecules.
authors.affiliation: Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Heverlee, Belgium.
authors.forename: Tetyana
authors.initials: T
authors.lastname: Beryozkina
authors.forename: Prasad
authors.initials: P
authors.lastname: Appukkuttan
authors.forename: Nuria
authors.initials: N
authors.lastname: Mont
authors.forename: Erik
authors.initials: E
authors.lastname: Van der Eycken
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D001372:Aza Compounds; D017705:Lignans; D014230:Triazoles; C442624:steganone; C002858:steganacin; D015107:4-Butyrolactone