Comparison of the protein profile of established and regressed hypertension-induced left ventricular hypertrophy.
Established left ventricular hypertrophy (LVH) showed a significant alteration in the cardiac protein profile compared with normal heart. The main finding of this work was to identify proteins differently expressed in hypertension-induced LVH and the fact that after regression of LVH (histologically determined), the proteome still maintains a number of expressed proteins characteristic of the hypertrophied heart. These unrecovered proteins play an essential role in the energy production pathway, in cellular stress defense and also in hypertrophy regulation.
Gallego-Delgado
Julio
J
Renal and Vascular Pathology Laboratory, Fundación Jiménez Díaz-Universidad Autónoma, Madrid 28040, Spain.
Lazaro
Alberto
A
Osende
Julio I
JI
Barderas
Maria G
MG
Duran
Maria C
MC
Vivanco
Fernando
F
Egido
Jesus
J
D000595:Amino Acid Sequence; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology; D017292:Doxazosin / Q000494:pharmacology; D015180:Electrophoresis, Gel, Two-Dimensional; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D019808:Losartan / Q000494:pharmacology; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D040901:Proteomics; D000077583:Quinapril; D051381:Rats; D011921:Rats, Inbred WKY; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D044005:Tetrahydroisoquinolines / Q000494:pharmacology
D000959:Antihypertensive Agents; D044005:Tetrahydroisoquinolines; D019808:Losartan; D017292:Doxazosin; D000077583:Quinapril