title: A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan.
abstract: OBJECTIVE
  We compared the dose requirement and side effect profile of total intravenous anaesthesia using Diprivan to generic propofol at a specific anaesthetic target level utilizing the bispectral index monitor to determine efficacy differences between the two products.
  
  
  METHODS
  Sixty women undergoing abdominal hysterectomy were induced with propofol 2 mg kg-1 and maintained with infusion (20-200 microg kg-1 min-1) adjusted to maintain a bispectral index of 50-65. Plasma propofol concentration was measured at 1 and 2 h post induction in 25 patients.
  
  
  RESULTS
  Mean (SD) drug doses adjusted for weight and time were similar in the Diprivan and generic propofol groups: 90 (30) microg kg-1 min-1 vs. 90 (20) microg kg-1 min-1 respectively. Mean (SD) plasma propofol levels at 1 and 2 h were also similar (3.0 (1.0) microg mL-1 vs. 3.6 (1.4) microg mL-1, P = 0.2 and 3.0 (1.9) microg mL-1 vs. 3.4 (1.6) microg mL-1, P = 0.58).
  
  
  CONCLUSIONS
  Diprivan and generic propofol have similar efficacy at a specified, bispectral index-defined, depth of anaesthesia.
authors.affiliation: Duke University Medical Center, Department of Anesthesiology, Division of Women's Anaesthesia Research Group, Durham, NC 27710, USA. olufo001@mc.duke.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: Olufolabi
authors.forename: T J
authors.initials: TJ
authors.lastname: Gan
authors.forename: H J
authors.initials: HJ
authors.lastname: Lacassie
authors.forename: W D
authors.initials: WD
authors.lastname: White
authors.forename: A S
authors.initials: AS
authors.lastname: Habib
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D016568:Drugs, Generic / Q000494:pharmacology / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D013447:Sulfites / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D016568:Drugs, Generic; D013447:Sulfites; D015742:Propofol