title: Confocal microscopy studies of a model oligoribonucleotide HIV inhibitor.
abstract: Previous work has shown that novel amphipalhic oligo and polyribonucleotides are potent inhibitors of HIV. It was hypothesized that the mechanism(s) of action for these compounds might be inhibition of retroviral reverse transcriptase (RT) and/or viral uptake by cells. A fluorescent oligonucleotide analog was prepared, and confocal microscopy studies were undertaken in order to examine oligonucleotide-cell interactions.
authors.affiliation: Westminster College, Salt Lake City, Utah, USA.
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Hyde
authors.forename: Keith
authors.initials: K
authors.lastname: Jensen
authors.forename: Jindrich
authors.initials: J
authors.lastname: Kopecek
authors.forename: Arthur D
authors.initials: AD
authors.lastname: Broom
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D018613:Microscopy, Confocal / Q000379:methods; D009843:Oligoribonucleotides / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D009843:Oligoribonucleotides; D018894:Reverse Transcriptase Inhibitors