Changes of the biochemical markers of bone turnover and periprosthetic bone remodeling after cemented hip arthroplasty.
Do periprosthetic bone loss and postoperative levels of the biochemical markers of bone turnover correlate? The femoral bone mineral density of 53 patients was measured by dual-energy x-ray absorptiometry 1 week and 2, 4, 6, and 12 months after cemented total hip arthroplasty (THA). Biochemical markers of bone turnover were assayed preoperatively and 3, 8, 16, and 24 weeks post-THA. Greatest bone loss was detected in the calcar region (region of interest 7), on average, 16% after 1 year. A marker of bone resorption, C-terminal telopeptides of type I collagen, increased 21% 3 weeks after THA. A significant correlation between periprosthetic bone loss in region of interest 7 after 1 year and type I collagen at 3 weeks was seen (r = -0.42, P = .003). Data suggest that periprosthetic bone loss is induced by an early postoperative high activity of osteoclasts. Counteracting this osteoclast activity with a limited and timely postoperative antiresorptive treatment may be concluded for clinical application.
Arabmotlagh
Mohammad
M
Department of Orthopaedic Surgery, University Hospital Frankfurt (Orthopädische Universitätsklinik Frankfurt-Stiftung Friedrichsheim), 60528 Frankfurt/M., Germany.
Sabljic
Robert
R
Rittmeister
Markus
M
D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000097:blood*; D015519:Bone Density; D016723:Bone Remodeling; D002484:Cementation; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D015415:Biomarkers; D024042:Collagen Type I