Role of svp in Drosophila pericardial cell growth.
The Drosophila dorsal vessel is a segmentally repeated linear organ, in which seven-up (svp) is expressed in two pairs of cardioblasts and two pairs of pericardial cells in each segment. Under the control of hedgehog (hh) signaling from the dorsal ectoderm, svp participates in diversifying cardioblast identities within each segment. In this experiment, the homozygous embryos of svp mutants exhibited an increase in cell size of Eve positive pericardial cells (EPCs) and a disarranged expression pattern, while the cardioblasts pattern of svp-lacZ expression was normal. In the meantime, the DAI muscle founders were absent in some segments in svp mutant embryos, and the dorsal somatic muscle patterning was also severely damaged in the late stage mutant embryos, suggesting that svp is required for the differentiation of Eve-positive pericardial cells and DA1 muscle founders and may have a role in EPC cell growth.
Yuan
Wu-Zhou
WZ
The Center for Heart Development, the Key Laboratory of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Zhang
Yue-Juan
YJ
Tang
Wen-Xian
WX
Wang
Jun
J
Li
Yong-Qing
YQ
Wang
Yue-Qun
YQ
Zhu
Chuan-Bing
CB
Yang
Hong
H
Wu
Xiu-Shan
XS
Rolf
Bodmer
B
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004330:Drosophila / Q000166:cytology* / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D006720:Homozygote; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D009132:Muscles / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D009154:Mutation; D032386:Myoblasts, Cardiac / Q000166:cytology / Q000378:metabolism; D010496:Pericardium / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D011987:Receptors, Steroid / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D011987:Receptors, Steroid; D014157:Transcription Factors; C052837:eve protein, Drosophila; C094295:svp protein, Drosophila