title: Identifying patients at risk of compromised margins following breast conservation for lobular carcinoma.
abstract: BACKGROUND
  The association of invasive lobular carcinoma with high rates of compromised margins in breast conservation makes choice of operation for these patients difficult. We sought to identify patients at risk of compromised margins following breast conservation surgery.
  
  
  METHODS
  We reviewed all patients with invasive lobular and invasive ductal carcinoma over a 5-year period (1999-2004). The imaging, pathology and surgical details of patients with invasive lobular carcinoma undergoing breast conservation were analyzed.
  
  
  RESULTS
  A total of 991 patients with invasive ductal carcinoma and 150 patients with invasive lobular carcinoma were identified. Lobular carcinomas had a compromised margin rate of 49% (n = 38/77) in breast conservation compared to 24% (n = 143/588) of ductal carcinomas (P < .0001). Mammographic size (P = .017), pathological size (P = .01), age (P = .03), multifocality (P < .0001), and lymphovascular invasion (P = .015) were significantly associated with compromised margins.
  
  
  CONCLUSIONS
  Invasive lobular carcinoma has a 49% rate of compromised margins following breast conservation. Mammographic size greater than 1.5 cm and young age were preoperative factors predictive of compromised margins.
authors.affiliation: Department of Surgery, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Dillon
authors.forename: Arnold D K
authors.initials: AD
authors.lastname: Hill
authors.forename: Fergal J
authors.initials: FJ
authors.lastname: Fleming
authors.forename: Ann
authors.initials: A
authors.lastname: O'Doherty
authors.forename: Cecily M
authors.initials: CM
authors.lastname: Quinn
authors.forename: Enda W
authors.initials: EW
authors.lastname: McDermott
authors.forename: Niall
authors.initials: N
authors.lastname: O'Higgins
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D044584:Carcinoma, Ductal / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000175:diagnosis*