title: Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities.
abstract: Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (1), were synthesized and their structure-activity relationships were studied.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hitotsuyanagi
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Hasuda
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fukaya
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
authors.forename: Ritsuo
authors.initials: R
authors.lastname: Aiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Shusuke
authors.initials: S
authors.lastname: Hashimoto
mesh_terms: D045744:Cell Line, Tumor; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds; D006801:Humans; D008958:Models, Molecular; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; C001899:triptolide