title: Polyhydroxylated 4-thiaflavans as multipotent antioxidants: protective effect on oxidative DNA damage in vitro.
abstract: Hydroxylated 4-thiaflavans, possessing the antioxidant features of catechol containing flavonoids and/or tocopherols, were evaluated as protective agents against oxidation damage induced in herring sperm DNA by cumene hydroperoxide (CumOOH) or by the glutathione/ferric ion (GSH/Fe(3+)) system. Our data indicate that the effective protection exerted by some of the tested compounds is overall higher than those provided by catechin and alpha-tocopherol, which might be attributed both to the scavenging properties and chelation of Fe(2+) ions.
authors.affiliation: Dipartimento di Farmacologia, Università di Firenze, Viale Pieraccini 6, I-50139, Firenze, Italy. maura.lodovici@unifi.it
authors.forename: Maura
authors.initials: M
authors.lastname: Lodovici
authors.forename: Stefano
authors.initials: S
authors.lastname: Menichetti
authors.forename: Caterina
authors.initials: C
authors.lastname: Viglianisi
authors.forename: Silvia
authors.initials: S
authors.lastname: Caldini
authors.forename: Elisa
authors.initials: E
authors.lastname: Giuliani
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004249:DNA Damage; D005290:Ferric Compounds / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D006900:Hydroxylation; D018384:Oxidative Stress; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000975:Antioxidants; D005290:Ferric Compounds; D005419:Flavonoids; D005978:Glutathione