title: Solid-phase synthesis of 5'-deoxy-5'-amino-clitocine analogues.
abstract: Several 6-substituted-amino-5'-deoxy-5'-amino-clitocine analogues were synthesized in a parallel fashion in solid phase. The desired scaffold was generated by coupling 2,3-O-bis-(t-butyldimethylsilyl)-5-N-(monomethoxytrityl-polystyrene-resin)-1,5-diamino-5-deoxy-beta-D-ribofuranose and 4, 6-dichloro-5-nitropyrimidine. The scaffold was then reacted with a variety of amines to generate a small library of 14 analogues of 5'-deoxy-5'-amino-clitocine following a protocol developed earlier.
authors.affiliation: Department of Medicinal Chemistry, Valeant Pharmaceuticals International, Inc., 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com
authors.forename: Chamakura V N S
authors.initials: CV
authors.lastname: Varaprasad
authors.forename: Qazi
authors.initials: Q
authors.lastname: Habib
authors.forename: Haoyun
authors.initials: H
authors.lastname: An
authors.forename: Zhi
authors.initials: Z
authors.lastname: Hong
mesh_terms: D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C448386:5'-deoxy-5'-amino-clitocine; D011741:Pyrimidine Nucleosides