title: Is there a role for cytokine based therapies in fibromyalgia.
abstract: Cytokines are glycoproteins that serve as chemical messengers between cells. They assist in the regulation of cell growth and repair and also have immune modulating properties. Cytokines play a role in diverse clinical processes and phenomena such as fatigue, fever, sleep, pain, stress and aching. A review of the fibromyalgia literature and related studies suggest that IL-1, IL-6 and IL-8 are dysregulated in the syndrome. Therapies directed against these cytokines may be of potential importance in the management of fibromyalgia.
authors.affiliation: Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dwallace@ucla.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Wallace
mesh_terms: D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D015673:Fatigue Syndrome, Chronic / Q000503:physiopathology; D005356:Fibromyalgia / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans
chemical_list: D016207:Cytokines