Hyperhomocysteinaemia, hyperlipidaemia and risk of venous thromboembolism in Shiraz.
To assess the risk of venous thromboembolism (VTE) associated with hyperhomocysteinaemia (hyper-Hcy) and hyperlipidaemia, we performed a case-control study. Fasting total homocysteine (Hcy), triglyceride and cholesterol levels were assessed in 43 patients with VTE and 43 controls. Mean Hcy level was significantly higher in the test group. Odds ratio (OR) for VTE in patients with hyper-Hcy was 2.7, with the association stronger in women and those under 50. The OR for those with both hypertriglyceridaemia and hypercholesterolaemia was significantly greater in those under 50. Increased risk for venous thrombosis was found among those under 50 having both lipid abnormalities.
Zamani
A
A
Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Omrani
G R
GR
Lankarani
K B
KB
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015897:Comorbidity; D005215:Fasting; D005260:Female; D006785:Hospitals, University; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D015228:Hypertriglyceridemia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013923:Thromboembolism / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D014504:Urban Health / Q000706:statistics & numerical data; D020246:Venous Thrombosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*