Severe gynecomastia in an African boy with perinatally acquired human immunodeficiency virus infection receiving highly active antiretroviral therapy.
Highly active antiretroviral therapy (HAART) slows the progression of human immunodeficiency virus (HIV) disease and lowers mortality and morbidity in children. Coincident with these advances, an increasing number of side effects are being reported. We describe an adolescent boy with perinatally acquired HIV infection who developed significant bilateral breast enlargement as a result of HAART. He required bilateral mastectomies. Pediatricians need to be aware of less common side effects of HAART.
Dzwonek
Agnieszka
A
Clinical Infectious Diseases Unit, Great Ormond Street Children's Hospital NHS Trust, London WC1N 3JH, United Kingdom.
Clapson
Margaret
M
Withey
Simon
S
Bates
Alan
A
Novelli
Vas
V
D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D044383:Black People; D006177:Gynecomastia / Q000139:chemically induced* / Q000601:surgery; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007630:Kenya; D008297:Male; D008408:Mastectomy