[Discovery of silicon fullerene and its application to nanomedicine].
By ab initio supercomputer simulation highly symmetrical cage-structures of silicon with nanometer-sizes were predicted without any experimental parameters. These novel structures, which now are called silicon fullerenes have been produced experimentally following our theoretical predictions. Since silicon is manufactured with ultra-high purity and cheep in cost, and is safe for health, all of these facts make it possible to be used in medical applications. Some of these nanostructured materials have appropriate optical properties emitting strong visible light suitable for cancer detections with additional peptide which has antigen-antibody reaction. Presently we select CdSe nanoparticles for actual in vivo experiments which already commercialized, and successful results to detect the exact position of cancer for mouse from outside of the body have been obtained.
Kawazoe
Yoshiyuki
Y
Center for Computational Materials Science, Institute for Materials Research, Tohoku Universit.
D000818:Animals; D003198:Computer Simulation; D051379:Mice; D036103:Nanotechnology; D009369:Neoplasms / Q000175:diagnosis; D012828:Silicones / Q000737:chemistry*
D012828:Silicones