title: Seasonal variance in serum levels of vitamin d determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec.
abstract: BACKGROUND
  Although the seasonal variance in serum levels of vitamin D in the elderly is well known, its significance on parathyroid hormone (PTH) remains controversial.
  
  
  OBJECTIVE
  To identify the variability and correlation between serum levels of vitamin D and PTH in a sample of community-dwelling elderly patients in the Province of Quebec, Canada, where vitamin D and calcium are supplemented in the food.
  
  
  METHODS
  Cross-sectional study in an ambulatory elderly population in the Province of Quebec. Samples were analyzed at the Metabolic and Calcium Research Centre, Royal Victoria Hospital, Montreal, Quebec. 256 healthy men and women aged 65-94 (mean age +/- SD: 72.8 +/- 5.6) were analyzed. Serum levels of 25-hydroxyvitamin D (25(OH)D3) and PTH were determined between 1994 and 1999 using commercial radioimmunoassay kits to measure calciotropic hormones. We examined data in different seasons of the year and observed the behavior of the data through time. A cut-off level of 25 nmol/l for 25(OH)D3 was established to define vitamin D deficiency. A correlation between vitamin D levels vs. PTH levels was also obtained.
  
  
  RESULTS
  There is a predominance of females with a 75% of the population. Among them, 32% showed levels of vitamin D <20 nmol/l as compared to 51% of the male population (p < 0.02). A seasonal variance in the levels of vitamin D was observed with the lower levels happening in early spring with a recovery at the end of the summer (p < 0.004). These low levels of vitamin D corresponded with an inverse pattern in the levels of PTH more importantly in early spring.
  
  
  CONCLUSIONS
  This study not only confirms previous reports that despite vitamin D food supplementation a vitamin D deficiency is still a finding in elderly population in the Northern hemisphere, but also that a compensatory change in PTH levels concurrently occurs with a potential significance on bone strength and risk of fractures.
authors.affiliation: S de Geriatría y Unidad de Investigación Hospital Universitario de Getafe, Madrid, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Vecino-Vecino
authors.forename: Miren
authors.initials: M
authors.lastname: Gratton
authors.forename: Richard
authors.initials: R
authors.lastname: Kremer
authors.forename: Leocadio
authors.initials: L
authors.lastname: Rodriguez-Mañas
authors.forename: Gustavo
authors.initials: G
authors.lastname: Duque
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002112:Calcifediol / Q000097:blood*; D002117:Calcitriol / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D011792:Quebec; D012621:Seasons; D016138:Walking
chemical_list: C470125:PTH protein, human; D010281:Parathyroid Hormone; D002117:Calcitriol; D002112:Calcifediol