title: Effects of feeding grains naturally contaminated with Fusarium mycotoxins on hepatic fractional protein synthesis rates of laying hens and the efficacy of a polymeric glucomannan mycotoxin adsorbent.
abstract: Experiments were conducted to evaluate the effects of feeding grains naturally contaminated with a combination of Fusarium mycotoxins on hepatic fractional protein synthesis rates (FSR) of laying hens. Thirty-six 32-wk-old laying hens were fed diets formulated with 1) uncontaminated grains, 2) contaminated grains, or 3) contaminated grains + 0.2% polymeric glucomannan mycotoxin adsorbent for a period of 4 wk. Hepatic FSR were measured in vivo by the flooding-dose method. The feeding of contaminated grains decreased hepatic FSR in laying hens compared with controls after 4 wk. The hepatic FSR of birds fed contaminated grains and contaminated grains + glucomannan mycotoxin adsorbent were not different. It was concluded that the in vivo hepatic FSR of laying hens was inhibited by the feeding of grains naturally contaminated with Fusarium mycotoxins and that this may explain some of the adverse effects seen when contaminated grains were fed to laying hens.
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada, N1G 2W1.
authors.forename: S R
authors.initials: SR
authors.lastname: Chowdhury
authors.forename: T K
authors.initials: TK
authors.lastname: Smith
mesh_terms: D000327:Adsorption; D000821:Animal Feed; D000818:Animals; D002645:Chickens; D004032:Diet; D005260:Female; D005506:Food Contamination; D005670:Fusarium / Q000472:pathogenicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008351:Mannans / Q000737:chemistry / Q000494:pharmacology*; D015651:Mycotoxicosis / Q000517:prevention & control; D009183:Mycotoxins / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D011201:Poultry Diseases / Q000139:chemically induced / Q000517:prevention & control*; D014176:Protein Biosynthesis / Q000187:drug effects*
chemical_list: D008351:Mannans; D009183:Mycotoxins; C022901:(1-6)-alpha-glucomannan