Predominant expression of rTERTb, an inactive TERT variant, in the adult rat brain.
The full-length and four alternatively spliced variant mRNA transcripts of rat TERT were identified. One of the variant, rTERTb, was predominantly expressed during brain development in accordance with the decrease in telomerase activity. The rTERTb mRNA encoded an inactive truncated protein. Alternative splicing of TERT may be important during brain development.
Kaneko
Ryosuke
R
Laboratory of Neurobiology and Behavioural Genetics, National Institute for Physiological Sciences, Okazaki 444-8787, Japan. rkaneko@nips.ac.jp
Esumi
Shigeyuki
S
Yagi
Takeshi
T
Hirabayashi
Takahiro
T
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D002460:Cell Line; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D019098:Telomerase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D017931:DNA Primers; D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; C509186:TERT protein, human; D019098:Telomerase; C509187:Tert protein, mouse