Nod1-dependent control of tumor growth.
Nod1, a cytosolic protein that senses meso-diaminopimelic acid-containing ligands derived from peptidoglycan, plays a role in host responses to invasive bacteria. Here we describe a function for Nod1, whereby it controls tumor formation. Cell lines derived from the human breast cancer epithelial cell line MCF-7 were used in a severe combined immune deficiency (SCID) mouse xenograft model to characterize a pathway linking Nod1 to the growth of estrogen-sensitive tumors. In MCF-7 cells, the absence of Nod1 correlates with tumor growth, an increased sensitivity to estrogen-induced cell proliferation, and a failure to undergo Nod1-dependent apoptosis. Conversely, overexpression of Nod1 in MCF-7 cells results in inhibition of estrogen-dependent tumor growth and reduction of estrogen-induced proliferative responses in vitro.
da Silva Correia
Jean
J
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Miranda
Yvonne
Y
Austin-Brown
Nikki
N
Hsu
Jenny
J
Mathison
John
J
Xiang
Rong
R
Zhou
Huamin
H
Li
Qinxi
Q
Han
Jiahuai
J
Ulevitch
Richard J
RJ
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D053474:Nod1 Signaling Adaptor Protein; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
D048868:Adaptor Proteins, Signal Transducing; C119067:NOD1 protein, human; D053474:Nod1 Signaling Adaptor Protein; D014409:Tumor Necrosis Factor-alpha