Development and virtual screening of target libraries.
The concomitant development of in silico screening technologies and of three-dimensional information on therapeutically relevant macromolecular targets makes it possible to navigate in the structural proteome and to identify targets fulfilling user-defined queries. This review illustrates some in-house recent advances in the development of target libraries and how they can be browsed to unravel chemogenomic information.
Rognan
Didier
D
Bioinformatics of the Drug, CNRS, UMR 7175, 74 route du Rhin, F-67400 Illkirch, France. didier.rognan@pharma.u-strasbg.fr
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003198:Computer Simulation; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D019151:Peptide Library; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
D008024:Ligands; D019151:Peptide Library; D043562:Receptors, G-Protein-Coupled