[Possibility of clinical usage of BMP in periodontal application; basic study].
It is necessary for using some carriers which hold bone morphogenetic protein (BMP) activity and maintain its osteoinductive ability, when BMP is applied to the tissue regeneration of the bone defect caused by periodontal diseases. It is indispensable for using some carriers which hold BMP activity and maintain its osteoinductive ability, when BMP is applied to the tissue regeneration of the bone defect caused by the diseases. Metals, ceramics and polymers are used for such carriers, and especially, polymers are indispensable. It is also important to prevent the penetration of epithelial tissue downgrowth, therefore, we innovated a noble resin material which can be formed to the thin film and has a property of light curing. Composite of this resin and BMP stably induced new bone. Cartilage induction in the organ culture on the artificial membrane was also succeed, and it will extend to the bone regeneration by means of re-transplantation of patient's derived tissues after the incubation.
Kawai
Tatsushi
T
Department of Dental Material Science, School of Dentistry, Aichi-Gakuin University.
Jinno
Satoshi
S
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D004337:Drug Carriers; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects; D010510:Periodontal Diseases / Q000188:drug therapy*; D011108:Polymers
D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D011108:Polymers