Magnetic particles as markers and carriers of biomolecules.
The detection and manipulation of biomolecules on a common platform is of considerable interest not only for application in devices such as diagnostic tools but also for basic research in biological and medical systems. A promising approach is the utilisation of magnetic particles as markers and carriers for biomolecules. The principle functionality of this approach is demonstrated by the authors. Magnetic particles used as markers can be detected by highly sensitive magnetoresistive sensors resulting in a purely electronic signal. A direct comparison with the standard fluorescence method reveals the advantages of using the magnetic particles. In addition, magnetic particles used as carriers can be manipulated on-chip via currents running through especially designed line patterns. Some current drawbacks and future aspects are discussed. The combination of sensing and manipulating magnetic particles is a promising choice for future integrated lab-on-a-chip systems.
Brückl
H
H
ARCS-Nano-Systemtechnologie, A-1220 Wien, Austria. herbert.brueckl@arcs.ac.at
Panhorst
M
M
Schotter
J
J
Kamp
P B
PB
Becker
A
A
D015415:Biomarkers / Q000032:analysis / Q000737:chemistry; D001704:Biopolymers / Q000032:analysis* / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry; D008280:Magnetics; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*; D015336:Molecular Probe Techniques; D015335:Molecular Probes / Q000032:analysis / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods
D015415:Biomarkers; D001704:Biopolymers; D004337:Drug Carriers; D015335:Molecular Probes