title: Pharmacokinetics of Astragaloside IV in rats by liquid chromatography coupled with tandem mass spectrometry.
abstract: Pharmacokinetics of Astragaloside IV (AGS-IV) in rats was studied by high performance liquid chromatography coupled with tandem mass spectrometry. The concentration in plasma was determined after i.v. administration of 1, 2, 4 mg/kg and p.o. administration of 20 mg/kg of AGS-IV. The AUC were linearly correlated to doses. Recoveries of AGS-IV in bile, urine and feces were also analyzed following i.v. dose of 2 mg/kg. Cumulative recovery of AGS-IV in bile reached 30.8% in 24h. Cumulative recovery of AGS-IV in urine and feces was 52.14%, which indicates that about 50% of AGS-IV was metabolized in vivo. The bioavailability of AGS-IV after p.o. administration was found to be 3.66%. These findings provide useful information for the research and development of AGS-IV and other potential agents.
authors.affiliation: College of Life and Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Du
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: G G
authors.initials: GG
authors.lastname: Chen
authors.forename: P
authors.initials: P
authors.lastname: Wei
authors.forename: C Y
authors.initials: CY
authors.lastname: Tu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001646:Bile / Q000737:chemistry; D002853:Chromatography, Liquid; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D007275:Injections, Intravenous; D013058:Mass Spectrometry; D008657:Metabolic Clearance Rate; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D014315:Triterpenes / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C052064:astragaloside A