title: Hyperperfusion syndrome in small-for-size livers.
abstract: BACKGROUND
  Portal hyperperfusion in small-for-size livers might seriously impair postoperative liver regeneration. Using an experimental model, we investigated splenectomy as a measure to reduce portal blood flow and its impact on postoperative recovery following extended liver resection.
  
  
  METHODS
  Wistar rats underwent partial (90%) hepatectomy with or without splenectomy under temporary inflow occlusion (30 min). In addition to 10-day survival rate, laser Doppler flowmetry of hepatic blood flow and fluorescence microscopic analysis of hepatic microcirculation were performed to assess the effect of splenectomy on initial microvascular reperfusion of liver remnants.
  
  
  RESULTS
  While postischemic perfusion failure was comparable between both groups, portal blood flow was significantly reduced after simultaneous splenectomy (3.5+/-0.4 vs. 5.4+/-0.4 ml/min). Moreover, red blood cell velocity and volumetric blood flow were reduced in splenectomized animals. These animals experienced lower AST levels (421+/-36 vs. 574+/-73 U/l) and a significantly increased survival rate, reaching 6.6+/-1.3 vs 2.6+/-0.8 days.
  
  
  CONCLUSIONS
  Simultaneous splenectomy significantly reduced the risk for postoperative hyperperfusion syndrome in small-for-size livers. Shear-stress-induced liver injury was diminished due to a significant reduction of portal venous blood flow, which positively influenced postoperative regeneration resulting in significantly higher survival.
authors.affiliation: Department of General, Visceral and Transplantation Surgery, Charité, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany. matthias.glanemann@charite.de
authors.forename: M
authors.initials: M
authors.lastname: Glanemann
authors.forename: C
authors.initials: C
authors.lastname: Eipel
authors.forename: A K
authors.initials: AK
authors.lastname: Nussler
authors.forename: B
authors.initials: B
authors.lastname: Vollmar
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D006498:Hepatectomy / Q000009:adverse effects; D008102:Liver Circulation; D008115:Liver Regeneration; D016031:Liver Transplantation / Q000009:adverse effects* / Q000473:pathology / Q000502:physiology; D008297:Male; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013156:Splenectomy; D013577:Syndrome