title: [A case of primary and solitary bone metastasis of testicular seminoma after orchiectomy].
abstract: A 40-year-old man with stage I left testicular seminoma who had been followed for 18 months after orchiectomy, complained of pain in his left upper extremity and dysbasia. Magnetic resonance imaging (MRI) and bone scintigraphy suggested multiple bone lesions in the thoracic vertebrae and right ischium, and bone biopsy revealed metastasis of seminoma. There was no evidence of other metastatic lesions. After he was treated with 2 courses of first-line chemotherapy consisting of peplomycin, etoposide, and cisplatin, which were followed by 2 courses of high-dose chemotherapy with carboplatin, etoposide, and ifosfamide, the metastatic lesions were nearly in complete response on MRI and bone scintigraphy and the result of fluorodeoxyglucose-positron emission tomography was negative, but the hCG-beta level remained slightly elevated. In most advanced testicular tumors, bone metastasis usually coexists with other metastatic lesions and appears as a secondary lesion. Herein, we report this rare case of primary and solitary bone metastasis from testicular seminoma after orchiectomy.
authors.affiliation: The Department of Urology, Nara Medical University.
authors.forename: Makito
authors.initials: M
authors.lastname: Miyake
authors.forename: Akihide
authors.initials: A
authors.lastname: Hirayama
authors.forename: Chie
authors.initials: C
authors.lastname: Matsushita
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kiyohide
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hirao
authors.forename: Akitaka
authors.initials: A
authors.lastname: Nonomura
authors.forename: Kenji
authors.initials: K
authors.lastname: Takashima
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D009919:Orchiectomy; D017663:Peplomycin / Q000008:administration & dosage; D049268:Positron-Emission Tomography; D018239:Seminoma / Q000556:secondary* / Q000601:surgery*; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery*
chemical_list: D019788:Fluorodeoxyglucose F18; D017663:Peplomycin; D005047:Etoposide; D002945:Cisplatin