Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice.
Aerial parts of Swertia longifolia Boiss. (Gentianaceae), which grows in the north of Iran, were screened for hepatoprotective activity against paracetamol (acetaminophen)-induced hepatotoxicity in Swiss mice. Pretreatment with total plant extract and swerchirin, the major component of the plant, significantly reduced the elevation of biochemical parameters, AST (aspartate aminotransferase), ALT (alanine aminotransferase) and ALP (alkaline phosphatase), the enzymes that are increased by liver damage (P < 0.001). Our results indicated that total plant extract and swerchirin were hepatoprotective in the range of 6-50 mg kg(-1) orally.
Hajimehdipoor
Homa
H
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sadeghi
Zhina
Z
Elmi
Sara
S
Elmi
Azadeh
A
Ghazi-Khansari
Mahmoud
M
Amanzadeh
Yaghoub
Y
Sadat-Ebrahimi
Seyyed-Esmaeal
SE
D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000633:toxicity; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology*; D029967:Swertia / Q000737:chemistry*; D044004:Xanthones / Q000494:pharmacology*
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D020011:Protective Agents; D044004:Xanthones; D000082:Acetaminophen; C034385:swerchirin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase