[Corticosteroid-loading PLA/PLGA-nanospheres].
We developed nanospheres for the intravenous injection that have had sustained release and targeting to the efficiently anti-inflammation effect. These nanospheres formed by poly(D,L-lactic/glycolic acid) (PLGA) or poly(D,L-lactic acid) (PLA), biodegradability and biocompatibility polymer, that were encapsulated betamethasone phosphate and zinc. Result of experimental inflammation models shown that there nanospheres increased effect by targeting to inflammatory sites and also promoted sustained release of betamethasone phosphate from the nanospheres. Moreover, the effect of nanospheres were stronger than clinical pharmaceutical preparation. We propose that these nanospheres are the pharmaceutical preparation to have efficient powerful inflammation action.
Izumo
Nobuo
N
Department of Pharmacology, Daiichi College of Pharmaceutical Sciencies.
Ishihara
Tsutomu
T
Mizushima
Yutaka
Y
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001623:Betamethasone / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D019344:Lactic Acid; D051379:Mice; D043942:Nanotubes; D011091:Polyesters; D011100:Polyglycolic Acid; D011108:Polymers
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D011091:Polyesters; D011108:Polymers; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D001623:Betamethasone