Methods to test for association between a disease and a multi-allelic marker applied to a candidate region.
We report the analysis results of the Genetic Analysis Workshop 14 simulated microsatellite marker dataset, using replicate 50 from the Danacaa population. We applied several methods for association analysis of multi-allelic markers to case-control data to study the association between Kofendrerd Personality Disorder and multi-allelic markers in a candidate region previously identified by the linkage analysis. Evidence for association was found for marker D03S0127 (p < 0.01). The analyses were done without any prior knowledge of the answers.
El Galta
Rachid
R
Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, P.O. Box 9604, 2300RC Leiden, The Netherlands. r.elgalta@lumc.nl
Hsu
Li
L
Houwing-Duistermaat
Jeanine J
JJ
D000483:Alleles; D056426:Genetic Loci / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans
D005819:Genetic Markers