title: Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients.
abstract: OBJECTIVE
  It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infected patients. The aim of our study was to investigate the influence of a functional polymorphism in the promoter region of the MTP gene (493G/T) on the development of HCV-related steatosis.
  
  
  METHODS
  Eighty-six chronic hepatitis C patients were studied to assess: the effects of body mass index, age, HCV genotype, and 493G/T MTP polymorphism on steatosis.
  
  
  RESULTS
  Steatosis was observed in 39 patients (45.3%). The 493G/T MTP polymorphism were not related to the development of steatosis.
  
  
  CONCLUSIONS
  The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C.
authors.affiliation: Laboratoire INSERM Unité 498, CHU du Bocage, BP 77908, 21079 Dijon cedex, France. jean-michel.petit@chu-dijon.fr
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Petit
authors.forename: David
authors.initials: D
authors.lastname: Masson
authors.forename: Anne
authors.initials: A
authors.lastname: Minello
authors.forename: Laurence
authors.initials: L
authors.lastname: Duvillard
authors.forename: Francoise
authors.initials: F
authors.lastname: Galland
authors.forename: Bruno
authors.initials: B
authors.lastname: Verges
authors.forename: Philippe
authors.initials: P
authors.lastname: Gambert
authors.forename: Patrick
authors.initials: P
authors.lastname: Hillon
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002352:Carrier Proteins / Q000235:genetics*; D005234:Fatty Liver / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014758:Viral Core Proteins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D014758:Viral Core Proteins; C106092:microsomal triglyceride transfer protein