title: The significance of voiding interval before testing urine samples for Chlamydia trachomatis in men.
abstract: OBJECTIVE
  To investigate the effect of time since last urination on chlamydial positivity rates in men.
  
  
  METHODS
  Prospective study on men attending a genitourinary medicine clinic who were asked for the last time of their urination before obtaining their urine sample for testing for Chlamydia trachomatis with the Cobas Amplicor polymerase chain reaction (PCR) assay.
  
  
  RESULTS
  Of the total of 1649 men studied, 621 (37.6% (95% CI 35.3% to 39.9%)) had a voiding interval of less than 2 hours. There was no statistical evidence of a difference in the positivity rate of chlamydial infection among men with a voiding interval of less than 2 hours (106/621, 17.1%) and that of men with a voiding interval of 2 hours or longer (170/1028, 16.5%); difference in proportions 0.5% (95% CI to 3.2% to 4.3%), p = 0.779.
  
  
  CONCLUSIONS
  Voiding interval does not have a significant impact on the performance of the Cobas Amplicor PCR assay in men.
authors.affiliation: Department of Genitourinary Medicine, Lothian University Hospitals Division, Edinburgh, UK. tirbad@yahoo.com
authors.forename: K
authors.initials: K
authors.lastname: Manavi
authors.forename: H
authors.initials: H
authors.lastname: Young
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002690:Chlamydia Infections / Q000175:diagnosis*; D002692:Chlamydia trachomatis; D019411:Clinical Laboratory Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013048:Specimen Handling; D013997:Time Factors; D016482:Urinalysis / Q000379:methods; D014554:Urination