title: Detection rate of prostate cancer on biopsy according to serum prostate-specific antigen in Korean men: a multicenter study.
abstract: OBJECTIVE
  To evaluate the detection rate of prostate cancer on biopsy according to the serum prostate-specific antigen (PSA) level in Korean men and compare the detection rate with those of Japanese and American men in other studies.
  
  
  METHODS
  We retrospectively analyzed 2422 Korean men who had undergone prostate biopsy at 12 medical centers from 1993 to 2002. In the case of a PSA level greater than 4.0 ng/mL or abnormal digital rectal examination findings, prostate biopsy was performed.
  
  
  RESULTS
  Of the 2422 men, 962 (39.7%) were diagnosed with prostate cancer. With PSA levels between 4.0 and 10.0 ng/mL, the detection rate of prostate cancer was 15.9%. This rate was similar to that of Japanese men (15.8%), but lower than that of American men (25%). In the cases with a PSA level greater than 10.0 ng/mL, the detection rate for Korean and Japanese men was 59.5%, and was also lower than the 67% rate for American men. When serum PSA levels were divided into five subgroups (less than 4.0, 4.0 to 10.0, 10.0 to 20.0, 20.0 to 100.0, and greater than 100.0 ng/mL), the detection rate of prostate cancer was 12.4%, 15.9%, 34.1%, 66.2%, and 93.8%, respectively.
  
  
  CONCLUSIONS
  In Korean men, the detection rate of prostate cancer on biopsy according to serum PSA level appears to be comparable to that for Japanese men and lower than that for American men.
authors.affiliation: Department of Urology, Inje University College of Medicine, Inje, Korea.
authors.forename: Won Jae
authors.initials: WJ
authors.lastname: Yang
authors.forename: Dong Hyeon
authors.initials: DH
authors.lastname: Lee
authors.forename: Byung Ha
authors.initials: BH
authors.lastname: Chung
authors.forename: Jin Seon
authors.initials: JS
authors.lastname: Cho
authors.forename: Young Deuk
authors.initials: YD
authors.lastname: Choi
authors.forename: Se Joong
authors.initials: SJ
authors.lastname: Kim
authors.forename: In Rae
authors.initials: IR
authors.lastname: Cho
authors.forename: Hong Sup
authors.initials: HS
authors.lastname: Kim
authors.forename: Chun Il
authors.initials: CI
authors.lastname: Kim
authors.forename: Sung Joon
authors.initials: SJ
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen