Hyperglycosylated ferritin in sera of HIV-1-infected patients treated with highly active antiretroviral therapy.
A study was conducted to determine the relationship between ferritin and glycosylated isoforms of ferritin and insulin resistance in 69 HIV-infected men receiving HAART. Ferritin levels were significantly correlated with aspartate aminotransferase, alanine aminotransferase, bilirubin and with insulin resistance. The ferritin isoelectric focusing patterns of five insulin-resistant HIV-infected patients under HAART showed large amounts of hyperglycosylated isoforms, which was not found in 56 control subjects and 46 untreated HIV-1-infected patients.
Malvoisin
Etienne
E
Fédération de Biochimie, Hôpital Edouard Herriot, CHU-Lyon, France. etienne.malvoisin@chu-lyon.fr
Livrozet
Jean-Michel
JM
Ducluzeau
Pierre-Henri
PH
Makloufi
Djamila
D
Cohen
Richard
R
Vincent
Nadine
N
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005293:Ferritins / Q000378:metabolism*; D006031:Glycosylation; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D007333:Insulin Resistance; D007525:Isoelectric Focusing; D008107:Liver Diseases / Q000378:metabolism* / Q000821:virology; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000821:virology
D005293:Ferritins