Confocal microscopy studies of a model oligoribonucleotide HIV inhibitor.
Previous work has shown that novel amphipalhic oligo and polyribonucleotides are potent inhibitors of HIV. It was hypothesized that the mechanism(s) of action for these compounds might be inhibition of retroviral reverse transcriptase (RT) and/or viral uptake by cells. A fluorescent oligonucleotide analog was prepared, and confocal microscopy studies were undertaken in order to examine oligonucleotide-cell interactions.
Hyde
Robyn M
RM
Westminster College, Salt Lake City, Utah, USA.
Jensen
Keith
K
Kopecek
Jindrich
J
Broom
Arthur D
AD
D019380:Anti-HIV Agents / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D018613:Microscopy, Confocal / Q000379:methods; D009843:Oligoribonucleotides / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
D019380:Anti-HIV Agents; D009843:Oligoribonucleotides; D018894:Reverse Transcriptase Inhibitors