title: [Effects of maternal hyperthyroidism and antithyroid drug therapy on thyroid function of newborn infants].
abstract: OBJECTIVE
  To evaluate the relationship between the incidence of abnormal thyroid function of newborns and maternal hyperthyroidism with antithyroid drug therapy.
  
  
  METHODS
  The clinical data of 35 neonates born to mothers with hyperthyroidism from 1983 to 2003 in Peking Union Medical College Hospital were retrospectively analyzed. According to the maternal thyroid function and the antithyroid drugs taken during pregnancy, subjects were divided into different groups.
  
  
  RESULTS
  The proportion of abnormal thyroid function in newborn was 48.6% (17/35). The prevalences of primary hypothyroidism, subclinical hypothyroidism, hypothyroxinemia, and central hypothyroidism were 29.4%, 29.4%, 35.3%, and 5.9%, respectively. The incidence of abnormal thyroid function of neonates whose mothers did not take the antithyroid drugs (ATDs) until the third trimester of pregnancy was significantly higher than those without and with ATDs during the first or second trimester (P < 0.01). The incidence of abnormal thyroid function significantly increased in premature neonates, neonates whose mothers with modest or heavy pregnant hypertension, or neonates whose core serum thyroid-stimulating hormone or serum anti-thyroid peroxidase antibodies levels were abnormal.
  
  
  CONCLUSIONS
  The risk of abnormal thyroid function of infants whose hyperthyroid mothers did not take ATDs until the third trimester of pregnancy may be increased. Prompt diagnosis and appropriate treatment of hyperthyroidism in pregnant women are essential for the prevention of neonatal thyroid functional abnormality.
authors.affiliation: Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. Lianlanx@public.bta.net.cn
authors.forename: Xiao-lan
authors.initials: XL
authors.lastname: Lian
authors.forename: Yao
authors.initials: Y
authors.lastname: Bai
authors.forename: Yun-hua
authors.initials: YH
authors.lastname: Xun
authors.forename: Wei-xin
authors.initials: WX
authors.lastname: Dai
authors.forename: Zhi-sheng
authors.initials: ZS
authors.lastname: Guo
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000188:drug therapy; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000151:congenital* / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors
chemical_list: D013956:Antithyroid Agents