HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin.
This report describes two novel HLA class II alleles, HLA-DRB1*0826 and HLA-DQB1*0627, that have been identified in two unrelated voluntary blood stem cell donors of Caucasian origin. HLA-DRB1*0826 is characterized by a nucleotide substitution (G to T) in exon 2 at position 163, leading to an amino acid exchange from argenine to leucine. The donor phenotype is HLA-A*0301,*2902; B*3501,*4403; Cw*0401,*1601; DRB1*0101,*0826; DQB1*0402, *0501. The HLA-DQB1*0627 alleles contain a nucleotide substitution at position 184 (T to C) resulting in an amino acid exchange from tyrosine to histidine. Family segregation analysis revealed that the HLA-DQB1*0627 allele belongs to the haplotype A*0101, B*1517, Cw*0701, DRB1*1302, DQB1*0627. The donor phenotype is HLA-A*0101; B*0801,*1517; Cw*0701; DRB1*1302,*1501; DQB1*0602,*0627.
Brixner
V
V
Institute of Transfusion Medicine and Immunohematology, RCBDS Baden-Württemberg - Hessen, Frankfurt am Main, Germany.
Mosebach
M
M
Schmidt
M
M
Hermann
S
S
Seifried
E
E
Martin
H
H
Seidl
C
C
D000483:Alleles; D001483:Base Sequence; D001782:Blood Donors; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000097:blood / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008562:Membrane Glycoproteins / Q000097:blood / Q000235:genetics*; D008969:Molecular Sequence Data; D010375:Pedigree; D012689:Sequence Homology, Nucleic Acid; D013234:Stem Cells / Q000276:immunology*; D044465:White People / Q000235:genetics*
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins