title: T cells and T-cell receptors in acute renal failure.
abstract: T cells are activated by antigen-independent as well as antigen-dependent mechanisms during ischemia-reperfusion injury to the kidney. In the current issue, a study by Savransky et al. suggests that antigen-dependent activation of T-cell receptors further contributes to the pathogenesis of ischemia-reperfusion injury.
authors.affiliation: Department of medicine, University fo Arkansas for Medical Sciences, Little Rock, AR 722015, USA. portilladidier@uams.edu
authors.forename: Didier
authors.initials: D
authors.lastname: Portilla
authors.forename: Mark D
authors.initials: MD
authors.lastname: Okusa
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000818:Animals; D018122:B7-1 Antigen / Q000502:physiology; D018106:CD28 Antigens / Q000502:physiology; D007113:Immunity, Innate; D007668:Kidney / Q000098:blood supply*; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015427:Reperfusion Injury / Q000209:etiology*; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D018122:B7-1 Antigen; D018106:CD28 Antigens; D011948:Receptors, Antigen, T-Cell