title: Primitive neuroectodermal tumor arising in the colon: report of a case.
abstract: Peripheral primitive neuroectodermal tumors (pPNETs) are usually found in the soft tissue of the extremities, paravertebral region, and chest wall. We report a rare case of a pPNET arising in the colon. A 59-year-old man underwent left hemicolectomy for an infiltrative ulcerating tumor, 11 cm long, in the descending colon. Histological examination of the resected specimen revealed small, round cell proliferation with rosette-like structures, and confirmed regional lymph node involvement and peritoneal dissemination near the primary tumor. Immunohistochemically, the tumor cells were positive for synaptophysin and MIC2 (CD 99). ESW-FLI1 chimeric mRNA was detected in the tumor by reverse transcriptase-polymerase chain reaction. The patient underwent resection of recurrence in the retroperitoneum 3 months later, but metastasis rapidly developed and he died of the disease 7 months after his first operation.
authors.affiliation: Department of Digestive Tract and General Surgery, Saitama Medical School, 1981 Kamoda, Tsujido-cho, Kawagoe, Saitama, 350-8550, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Kuwabara
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirakawa
authors.forename: Masaru
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakada
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Daijo
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Miura
authors.forename: Shinji
authors.initials: S
authors.lastname: Itoyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Heike
mesh_terms: D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery*; D018450:Disease Progression; D017809:Fatal Outcome; D052138:Genes, Neoplasm; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000601:surgery*; D012333:RNA, Messenger / Q000032:analysis; D035583:Rare Diseases; D012086:Reoperation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger