title: Pneumonia with marked pleural effusion caused by Aspergillus infection.
abstract: We present a case of pneumonia with marked pleural effusion caused by Aspergillus infection in a 2-year-old Japanese girl with Down's syndrome. The patient was previously diagnosed with acute myeloid leukemia, developing the pneumonia during induction treatment. Although no pathogens could be isolated from any clinical specimens, 135,000 copies/mL of Aspergillus DNA were detected in the pleural fluid using real time polymerase chain reaction. The copy numbers of DNA decreased rapidly after appropriate antifungal treatment.
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Miyake
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Ayano
authors.initials: A
authors.lastname: Fujita
authors.forename: Chie
authors.initials: C
authors.lastname: Usui
authors.forename: Shiho
authors.initials: S
authors.lastname: Akimoto
authors.forename: Toshio
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Saito
authors.forename: Yoshizo
authors.initials: Y
authors.lastname: Asano
mesh_terms: D001228:Aspergillosis / Q000150:complications* / Q000382:microbiology; D001230:Aspergillus / Q000235:genetics / Q000302:isolation & purification; D002675:Child, Preschool; D004271:DNA, Fungal / Q000032:analysis; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000382:microbiology; D010996:Pleural Effusion / Q000209:etiology* / Q000382:microbiology; D011014:Pneumonia / Q000150:complications* / Q000382:microbiology; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D004271:DNA, Fungal