An improved synthesis of alpha-carbolines under microwave irradiation.
[reaction: see text]. Alpha-carbolines are interesting core structures for designing DNA-interacting small molecules. However, these compounds are not commercially available and their synthetic methods are low yielding or time consuming. The shortest synthetic route, the modified Graebe-Ullmann reaction, has been optimized by using microwave heating in four different types of apparatus to give shorter reaction times and enhanced yields. Optimized conditions enabled the preparation of a small library of alpha-carbolines.
Vera-Luque
Patricia
P
Departamento de Química Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.
Alajarín
Ramón
R
Alvarez-Builla
Julio
J
Vaquero
Juan J
JJ
D002243:Carbolines / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D011827:Radiation
D002243:Carbolines; C055571:alpha-carboline