Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechins.
(-)-Epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg) reduce oxacillin resistance in mecA-containing strains of Staphylococcus aureus. Their binding to staphylococcal cells is enhanced by the nongalloyl analogues (-)-epicatechin (EC) and (-)-epigallocatechin (EGC). EC and EGC significantly increased the capacity of ECg and EGCg to reduce levels of staphylococcal oxacillin resistance.
Stapleton
Paul D
PD
Microbiology Group, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
Shah
Saroj
S
Hara
Yukihiko
Y
Taylor
Peter W
PW
D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate; C057580:gallocatechol; D010068:Oxacillin