Mammalian variations on a theme: a Smo and Sufu surprise.
Hedgehog signaling plays a critical role during development and tumorigenesis. While much mechanistic insight has come from pathway investigations in the fruit fly, recent studies suggest a distinct mammalian strategy for signaling from Smoothened to Gli through the novel protein Suppressor of Fused that may have therapeutic implications.
Oro
Anthony E
AE
Program in Epithelial Biology, Stanford University School of Medicine, CCSR 2145c, 269 Campus Drive, Stanford, CA 94305, USA. oro@cmgm.stanford.edu
D000818:Animals; D004330:Drosophila; D053823:Hedgehog Proteins; D008322:Mammals; D008954:Models, Biological; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism
D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled; D012097:Repressor Proteins; D015534:Trans-Activators