title: Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction.
abstract: OBJECTIVE
  Release of progenitor cells is observed during inflammatory conditions and contributes to neovascularization. We, therefore, sought to investigate the relationship of circulating progenitor cells and interleukin (IL)-8 in acute myocardial infarction (AMI).
  
  
  RESULTS
  From patients with stable angina and AMI, serial venous blood samples were obtained. The number of circulating CD133+CD45- progenitor cells, endothelial progenitor cells (EPCs), and circulating endothelial P1H12+CD45- cells was analyzed by flow cytometry. After stenting in patients with AMI, an increase in plasma IL-8 and vascular endothelial growth factor (VEGF) concentrations was observed, which was only minimal in patients with stable angina. Only in patients with AMI, this was followed by an increase in circulating CD133+CD45- progenitor cells. In contrast, circulating endothelial P1H12+CD45- cells and E-selectin RNA expression in peripheral blood were only elevated early in AMI, indicating shedding of activated endothelial cells. Multivariable analysis revealed an association of IL-8 and circulating CD133+CD45- progenitor cells in AMI, in addition to statin therapy and risk factor profile.
  
  
  CONCLUSIONS
  In AMI, IL-8 is associated with circulating progenitor cells. In addition to the pro-angiogenic functions of IL-8 and VEGF, this mechanism may contribute to new vessel generation and, thereby, improve myocardial function.
authors.affiliation: Deutsches Herzzentrum und 1. Medizinische Klinik der Technischen Universität München, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schömig
authors.forename: Gabriele
authors.initials: G
authors.lastname: Busch
authors.forename: Birgit
authors.initials: B
authors.lastname: Steppich
authors.forename: Dominik
authors.initials: D
authors.lastname: Sepp
authors.forename: Jan
authors.initials: J
authors.lastname: Kaufmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Stein
authors.forename: Albert
authors.initials: A
authors.lastname: Schömig
authors.forename: Ilka
authors.initials: I
authors.lastname: Ott
mesh_terms: D000071916:AC133 Antigen; D000787:Angina Pectoris / Q000097:blood / Q000473:pathology; D015703:Antigens, CD; D042783:Endothelial Cells / Q000473:pathology; D005434:Flow Cytometry; D006023:Glycoproteins; D006801:Humans; D016209:Interleukin-8 / Q000097:blood / Q000502:physiology*; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology*; D010455:Peptides; D013234:Stem Cells; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D016209:Interleukin-8; C000606023:PROM1 protein, human; D010455:Peptides; D042461:Vascular Endothelial Growth Factor A