title: Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni.
abstract: We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.
authors.affiliation: Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. jennifer.keiser@unibas.ch
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keiser
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Bernard
authors.initials: B
authors.lastname: Fried
authors.forename: Jürg
authors.initials: J
authors.lastname: Utzinger
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology* / Q000627:therapeutic use; D004449:Echinostoma / Q000187:drug effects*; D004451:Echinostomiasis / Q000188:drug therapy*; D005260:Female; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D037621:Artemisinins; D012717:Sesquiterpenes; D011223:Praziquantel; C031327:artemisinin