The effect of atropine on plasma gastric inhibitory polypeptide (GIP), serum insulin, and blood glucose after intraduodenal infusion of fat.
Six healthy men were studied with a 10-min intraduodenal infusion of 100 ml corn oil (66 g triglycerides) on 2 separate days. On one of the days 0.5 mg atropine sulfate was also given intravenously before start of the fat infusion, followed by 0.75 mg atropine sulfate infused during the first hour. On the day without atropine, plasma GIP and serum insulin increased significantly. The increases in plasma GIP and serum insulin were significantly attenuated by atropine. Blood glucose fell on both days, the fall being slightly delayed by atropine.
Jorde
R
R
Laboratory of Gastroenterology, Dept. of Medicine, University Hospital of Tromsø, Tromsø, Norway.
Burhol
P G
PG
Waldum
H L
HL
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D004386:Duodenum; D005223:Fats / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D019518:Postprandial Period / Q000187:drug effects*; D011863:Radioimmunoassay; D012016:Reference Values
D001786:Blood Glucose; D005223:Fats; D007328:Insulin; D010276:Parasympatholytics; D005749:Gastric Inhibitory Polypeptide; D001285:Atropine