title: Cytotoxic activities of water-soluble chitosan derivatives with different degree of deacetylation.
abstract: Chitosans with different degree of deacetylation (DD) (90% and 50% deacetylated chitosan) were prepared by N-deacetylation followed by grafted onto chitosan to form water-soluble aminoethyl-chitosan (AE-chitosan), and dimetylaminoethyl-chitosan (DMAE-chitosan), diethylaminoethyl-chitosan (DEAE-chitosan). In the present study, cytotoxic activities of the chitosan derivatives were evaluated using three tumor cell lines and two normal cell lines, and structure-activity relationship was suggested. The cytotoxic activity was dependent on their DD and substituted group.
authors.affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Je
authors.forename: Young-Sook
authors.initials: YS
authors.lastname: Cho
authors.forename: Se-Kwon
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000107:Acetylation; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000737:chemistry*; D006801:Humans; D012995:Solubility; D014867:Water
chemical_list: D000970:Antineoplastic Agents; D004983:Ethanolamines; D014867:Water; D048271:Chitosan