The platelet componentof hemostasis in aortic surgery.
The lack of significant changes in the count and function of platelets in aortic surgery without use of cardiopulmonary bypass (CPB) confirms that factors of extracorporeal circulation exert a remarkable adverse action on the platelet component of hemostasis. In operations performed under hypothermic perfusion or circulatory arrest, disorders of the platelet component even in case of the use of 2 mln. CIU trasylol (aprotinin) are most pronounced which gives rise to excessive postoperative blood loss in the given patient group. It may be assumed that the increase of the dose of trasylol up to 6 mln. CIU will allow, owing to its cytoprotective action, preserve as well as possible the quantitative and qualitative properties of platelets.
Charnaia
M A
MA
Russian Scientific Center of Surgery, RAMS, Moscow, Russia.
Morozov
Iu A
IuA
Gladysheva
V G
VG
Belov
Iu V
IuV
Isaeva
A M
AM
D001014:Aortic Aneurysm / Q000097:blood / Q000601:surgery*; D007611:Aprotinin / Q000627:therapeutic use; D001792:Blood Platelets / Q000502:physiology*; D005500:Follow-Up Studies; D006487:Hemostasis / Q000502:physiology*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010976:Platelet Count; D019106:Postoperative Hemorrhage / Q000097:blood / Q000517:prevention & control; D013997:Time Factors; D014656:Vascular Surgical Procedures
D006490:Hemostatics; D007611:Aprotinin