Endovascular treatment of cerebral arteriovenous malformations with Onyx embolization.
BACKGROUND
In the past 5 years, new treatment materials and techniques offering a different concept in endovascular treatment have been described for cerebral arteriovenous malformations (CAVMs). The aim of this study was to assess the endovascular treatment of CAVMs by using a liquid embolic material, Onyx (Micro Therapeutics. Inc., Irvine, CA, USA).


METHODS
From September 2003 to September 2004, Onyx was used to treat 22 patients with CAVMs. Ten AVMS were located in functional areas, 8 in deep cerebral areas, and 4 in the cerebellar hemisphere. The size of CAVMs was about 3 cm in diameter in 5 patients, 3-6 cm in 11, and more than 6 cm in 6.


RESULTS
In the 22 patients, Onyx embolization was successful. Nidus occlusion was complete in 3 patients, > 90% in 8, > 80% and < 90% in 6, and > 50% and < 80% in 5. Complications included transient neurological deficits in 2 patients, and adherence of microcatheter to the site of injection in 2.


CONCLUSIONS
Being non-adhesiveness, Onyx is a safe and satisfactory embolic material in the treatment of CAVMs. But its long-term efficacy awaits further follow-up.
He
Hong-wei
HW
Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan 250012, China.
Jiang
Chu-han
CH
Liu
Hong-bing
HB
Li
You-xiang
YX
Zhang
Jing-bo
JB
Wu
Zhong-xue
ZX
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000628:therapy*; D008297:Male; D008875:Middle Aged
D004121:Dimethyl Sulfoxide