title: New double quantum coherence filter for localized detection of glutathione in vivo.
abstract: In this work, a new double quantum filter for glutathione (GSH) editing is introduced, combined with the point-resolved spectroscopy localization sequence (PRESS), and demonstrated in vivo. Compared to the conventional double quantum coherence filter, the new filter has two major advantages. First, it eliminates the need for calibration scans for optimizing the signal yield, making it more efficient and convenient for routine use. Second, it removes the influence of water saturation pulses on the GSH yield, further improving its accuracy. With this method, GSH concentrations in the left and right parietal lobes of five healthy volunteers were determined to be 0.91+/-0.16 mM and 0.89+/-0.16 mM, respectively, in agreement with previous studies.
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta GA, USA.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhao
authors.forename: Keith
authors.initials: K
authors.lastname: Heberlein
authors.forename: Carolyn
authors.initials: C
authors.lastname: Jonas
authors.forename: Dean P
authors.initials: DP
authors.lastname: Jones
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
mesh_terms: D001923:Brain Chemistry; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010296:Parietal Lobe / Q000737:chemistry
chemical_list: D005978:Glutathione