[The correlation between polymorphism at position -511C/T in the promoter region of interleukin 1B and the severity of coronary heart disease].
OBJECTIVE
To investigate the correlation between polymorphism at position -511C/T in the promoter region of interleukin 1B (IL1B) and the severity of coronary heart disease (CHD).


METHODS
The polymerase chain reaction-restriction fragment length polymorphism technique was applied to analyze the polymorphisms of IL1B -511C/T in 127 patients with CHD and 152 controls. And the serum level of lipoproteins was detected by enzymology method.


RESULTS
The distribution of IL1B -511C/T polymorphism between acute coronary syndrome (ACS) patients and controls was significantly different (chi-square test=5.72, P<0.01). CT and TT genotype carriers were in increased risk of ACS with more double ratio to CC genotype (OR=2.56, 95%CI=1.17-5.59). In CHD group, total cholesterol and low density lipoprotein-cholesterol levels of patients with CT and TT genotypes (6.09+/-0.97 mmol/L and 3.97+/-0.92 mmol/L) were significantly higher than those of patients with CC genotype (5.12+/-0.56 mmol/L and 2.87+/-0.71 mmol/L, P<0.05).


CONCLUSIONS
The polymorphism at position -511C/T in IL1B is associated with the severity of CHD, and the DNA variation at this position may affect the secretion of IL1B, and aggravate the reaction of inflammation and dyslipoidemia.
Zhang
Yuan-ming
YM
Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumq, Xinjiang 830054, P.R.China. zymdxx@163.com
Zhong
Liang-jun
LJ
He
Bing-xian
BX
Li
Wen-chao
WC
Nie
Jing
J
Wang
Xuan
X
Chen
Xiao-tao
XT
D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D053583:Interleukin-1beta; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012720:Severity of Illness Index
C508585:IL1B protein, human; D007375:Interleukin-1; D053583:Interleukin-1beta