A new neuroprotective compound of Ligustrum japonicum leaves.
A new secoiridoid glycoside characterized as (8 Z)-nuezhenide A along with five known glycosides, (8 E)-nuezhenide, (8 Z)-nuezhenide, oleonuezhenide, osmanthuside B and osmanthuside D, were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
Sung
Sang Hyun
SH
Elcom Science Co., Ltd., Seoul, Korea.
Kim
Eun Sil
ES
Lee
Ki Yong
KY
Lee
Mi Kyeong
MK
Kim
Young Choong
YC
D045744:Cell Line, Tumor; D006801:Humans; D031659:Ligustrum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification*; D016627:Oxidopamine; D018515:Plant Leaves / Q000737:chemistry*
D018696:Neuroprotective Agents; D016627:Oxidopamine