An experimental research into the anti-aging effects of Radix Arctii Lappae.
OBJECTIVE
To delve into the anti-aging effects and mechanism of Niubanggen (Radix Arctii Lappae).


METHODS
The activity of SOD and the content of MDA and lipofuscin in the tissues of the liver, brain and blood serum of the lab rats were observed 30 days after they had been fed with the Niubanggen decoction.


RESULTS
The activity of SOD in the liver tissue and blood serum of the decoction-fed lab rats was improved dramatically (P<0.05 or P<0.01), the content of MDA in the brain tissue and blood serum lowered obviously (P<0.05 or P<0.01), and the content of lipofuscin dropped distinctly (P<0.01).


CONCLUSIONS
The mechanism of the anti-aging effects of the Niubanggen is mainly obtained by raising the activity of SOD and reducing the contents of MDA and lipofuscin.
Liu
Shumin
S
Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Li
Yujie
Y
Li
Shulian
S
Luo
Mingmei
M
Liu
Xinlin
X
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D031170:Arctium / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008062:Lipofuscin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008062:Lipofuscin; D008315:Malondialdehyde; D013482:Superoxide Dismutase