title: Endogenous production of nitric oxide synthase inhibitors.
abstract: Numerous reports have indicated that the plasma concentration of endogenously produced inhibitors of nitric oxide synthase are elevated in human disease states. In this review we discuss recent advances in our understanding of the enzymes responsible for the synthesis of these inhibitors.
authors.affiliation: Centre for Clinical Pharmacology, The British Heart Foundation Laboratories, University College London, UK.
authors.forename: Shelagh
authors.initials: S
authors.lastname: Anthony
authors.forename: James
authors.initials: J
authors.lastname: Leiper
authors.forename: Patrick
authors.initials: P
authors.lastname: Vallance
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000097:blood / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D011484:Protein-Arginine N-Methyltransferases / Q000235:genetics / Q000378:metabolism; D051437:Renal Insufficiency / Q000097:blood; D019323:omega-N-Methylarginine / Q000378:metabolism / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D019323:omega-N-Methylarginine; C018524:N,N-dimethylarginine; D001120:Arginine; D019001:Nitric Oxide Synthase; D011484:Protein-Arginine N-Methyltransferases