[Physiopathogenic aspects of HIV-associated primary brain lymphomas].
HIV-associated Primary brain lymphomas (PBLs) are usually diffuse, large B-cell lymphomas (DLBCLs). In contrast to those occurring in immunocompetent patients, nearly all HIV-associated PBLs are associated with Epstein-Barr virus (EBV). Since viral latency proteins are target antigens for anti-viral cytotoxic T lymphocytes, the double immunodeficiency (HIV infection, central nervous system microenvironment) favors the expression of viral latency proteins (LMP-1, EBNA2). These proteins play a major role in immortalization and transformation of infected B lymphocytes through cell cycle activation and apoptosis inhibition.
Camilleri-Broët
S
S
Université Paris-Descartes, Faculté de médecine, Hôtel Dieu, AP-HP. sophie.camilleri-broet@htd.ap-hop-paris.fr
Raphaël
M
M
D001402:B-Lymphocytes / Q000473:pathology / Q000821:virology; D001706:Biopsy; D001921:Brain / Q000473:pathology / Q000821:virology; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000821:virology; D002555:Cerebrospinal Fluid / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000150:complications; D006678:HIV / Q000502:physiology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000134:cerebrospinal fluid / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000134:cerebrospinal fluid / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000821:virology