title: Correlation of basic fibroblast growth factor expression with the invasion and the prognosis of oral squamous cell carcinoma.
abstract: BACKGROUND
  The aim of this study was to evaluate the relationship between the expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in cancer cells and fibroblasts at the invasive front of oral squamous cell carcinoma (OSCC), and the pathologic and clinical characteristics.
  
  
  METHODS
  Sections of 61 biopsy specimens of primary OSCC were immunostained to assess the expression of bFGF and FGFR-1 in cancer cells and fibroblasts at the invasive front.
  
  
  RESULTS
  The bFGF and FGFR-1 expressions in the cancer cells were evident in all specimens, whilst, in fibroblasts, they were detected in 41 (67%) of 61 specimens. These expressions in the fibroblasts occurred notably more often in high-invasive OSCC specimens than low-invasive OSCC specimens. The prevalence of bFGF and FGFR-1 expressions in cases with lymph node metastasis was significantly higher (P < 0.05) than in cases without metastasis. Moreover, these expressions were well correlated with patient prognosis.
  
  
  CONCLUSIONS
  This study concludes that bFGF and FGFR-1 expressions in fibroblasts at the invasive front are linked to the mode of invasion and the prognosis in OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. t-hase@oral.m.kanazawa-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hase
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kawashiri
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nozaki
authors.forename: Natsuyo
authors.initials: N
authors.lastname: Noguchi
authors.forename: Koroku
authors.initials: K
authors.lastname: Kato
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Nakaya
authors.forename: Kiyomasa
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D000368:Aged; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D016009:Chi-Square Distribution; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D005347:Fibroblasts / Q000737:chemistry; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000737:chemistry*; D011379:Prognosis; D011817:Rabbits; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000032:analysis*; D018709:Statistics, Nonparametric; D016019:Survival Analysis
chemical_list: D016222:Fibroblast Growth Factor 2; D051496:Receptor, Fibroblast Growth Factor, Type 1