title: Phosphoinositide 3-kinase controls early and late events in mammalian cell division.
abstract: Phosphoinositide 3-kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin-dependent kinases. Fine-tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer.
authors.affiliation: Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain.
authors.forename: Zaira
authors.initials: Z
authors.lastname: García
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Miriam
authors.initials: M
authors.lastname: Marqués
authors.forename: Isabel
authors.initials: I
authors.lastname: Cortés
authors.forename: Ana C
authors.initials: AC
authors.lastname: Carrera
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D018844:Cyclin-Dependent Kinases