title: Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.
abstract: RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this agent effected significant tumor growth inhibition at doses as low as 50mg/kg.
authors.affiliation: Hoffmann-La Roche Inc., 340 Kingsland Str., Nutley, NJ 07110-1199, USA. lee.mcdermott@roche.com
authors.forename: Lee A
authors.initials: LA
authors.lastname: McDermott
authors.forename: Brian
authors.initials: B
authors.lastname: Higgins
authors.forename: Mary
authors.initials: M
authors.lastname: Simcox
authors.forename: Kin-Chun
authors.initials: KC
authors.lastname: Luk
authors.forename: Tom
authors.initials: T
authors.lastname: Nevins
authors.forename: Kenneth
authors.initials: K
authors.lastname: Kolinsky
authors.forename: Melissa
authors.initials: M
authors.lastname: Smith
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Jia K
authors.initials: JK
authors.lastname: Li
authors.forename: Yingsi
authors.initials: Y
authors.lastname: Chen
authors.forename: June
authors.initials: J
authors.lastname: Ke
authors.forename: Navita
authors.initials: N
authors.lastname: Mallalieu
authors.forename: Tom
authors.initials: T
authors.lastname: Egan
authors.forename: Stan
authors.initials: S
authors.lastname: Kolis
authors.forename: Aruna
authors.initials: A
authors.lastname: Railkar
authors.forename: Louise
authors.initials: L
authors.lastname: Gerber
authors.forename: Jin-Jun
authors.initials: JJ
authors.lastname: Liu
authors.forename: Fred
authors.initials: F
authors.lastname: Konzelmann
authors.forename: Zhuming
authors.initials: Z
authors.lastname: Zhang
authors.forename: Tom
authors.initials: T
authors.lastname: Flynn
authors.forename: Omar
authors.initials: O
authors.lastname: Morales
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000098:blood supply*; D009389:Neovascularization, Pathologic; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017468:Receptors, Fibroblast Growth Factor / Q000037:antagonists & inhibitors; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D011743:Pyrimidines; C511816:RO4396686; D017468:Receptors, Fibroblast Growth Factor; D042461:Vascular Endothelial Growth Factor A; D017479:Receptors, Platelet-Derived Growth Factor; D040301:Vascular Endothelial Growth Factor Receptor-2