title: Streptococcus pyogenes isolates with high-level macrolide resistance and reduced susceptibility to telithromycin associated with 23S rRNA mutations.
abstract: Seven high-level macrolide-resistant Streptococcus pyogenes isolates had reduced activity to telithromycin but were negative for methylation and efflux genes. All were of the constitutive phenotype, were clonally related (emm type 12 and MLST type 36), and had identical dual mutations (A2058G and U2166C) in domain V of 23S rRNA.
authors.affiliation: GR Micro Limited, 7-9 William Road, London, NW1 3ER, United Kingdom. D.Farrell@grmicro.co.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Farrell
authors.forename: Jemma
authors.initials: J
authors.lastname: Shackcloth
authors.forename: Karen A
authors.initials: KA
authors.lastname: Barbadora
authors.forename: Michael D
authors.initials: MD
authors.lastname: Green
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D048628:Ketolides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D012338:RNA, Ribosomal, 23S; C106791:telithromycin