title: CD4+CD3- cells regulate the organization of lymphoid tissue and T-cell memory for antibody responses.
abstract: This review highlights the role of a CD4(+)CD3(-) accessory cell in the development of organized lymphoid infrastructures as well as in the development of high-affinity antibody responses and T-cell memory. These 2 functions are linked in the development of the vertebrate immune system and are effected by the constitutive expression of 2 sets of tumor necrosis factor (TNF) family members. The expression of lymphotoxin 3 (LT3), LT3, and TNF-3, which are closely linked genetically, affects the organization of lymphoid structures into B-cell and T-cell areas; the dual expression of OX40 ligand (TNFSF4) and CD30 ligand (TNFSF8) influences both the survival of T-cells within germinal centers and T-cell memory.
authors.affiliation: MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK. p.j.l.lane@bham.ac.uk
authors.forename: Peter J L
authors.initials: PJ
authors.lastname: Lane
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Kim
authors.forename: Fabrina M C
authors.initials: FM
authors.lastname: Gaspal
authors.forename: Fiona M
authors.initials: FM
authors.lastname: McConnell
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D017252:CD3 Complex / Q000235:genetics / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002877:Chromosomes, Human / Q000235:genetics / Q000276:immunology; D018858:Germinal Center / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000235:genetics / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000276:immunology
chemical_list: D017252:CD3 Complex; D008233:Lymphotoxin-alpha