Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.
Some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas were prepared and evaluated as putative potassium channel openers on the vascular and uterine smooth muscle tissue (myorelaxant effect), as well as on insulin-secreting pancreatic islets (inhibition of insulin release). The pharmacological results indicated that these compounds exhibited a marked biological activity on these three tissues.
Khelili
Smail
S
Laboratoire de Chimie Pharmaceutique, de Pharmacologie et d'Ecotoxicologie, Faculté des Sciences, Université de Jijel, B.P. 98 Ouled Aissa, 18000 Jijel, Algeria.
Lebrun
Philippe
P
de Tullio
Pascal
P
Pirotte
Bernard
B
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology*; D019806:Cromakalim / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000096:biosynthesis; D007515:Islets of Langerhans / Q000187:drug effects; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology
D001578:Benzopyrans; D007004:Hypoglycemic Agents; D007328:Insulin; D014665:Vasodilator Agents; D019806:Cromakalim; D014508:Urea