Celiac disease (CD), ulcerative colitis (UC), and primary sclerosing cholangitis (PSC) in one patient: a family study.
We discuss the case of a 17-year-old male who at the age of 7 was diagnosed with celiac disease (CD) together with ulcerative colitis (UC) and primary sclerosing cholangitis (PSC). The patient was treated with gluten-free diet and immunosuppressive drugs (azathioprine), and currently remains asymptomatic. The patient's younger, 12-year-old sister was diagnosed with CD when she was 1.5 years old, and at 7 years she developed type-I diabetes mellitus, which was difficult to control. A family study was made, and both parents were found to be affected with silent CD. All were DQ2 (+). In relation to the case and family study, we provide a series of comments related to CD and its complications.
Cadahía
V
V
Service of Digestive Diseases, Hospital Universitario Central de Asturias, Oviedo, Spain. vallecadahia@terra.es
Rodrigo
L
L
Fuentes
D
D
Riestra
S
S
de Francisco
R
R
Fernández
M
M
D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000235:genetics*; D002648:Child; D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree