Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary.
OBJECTIVE
To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers.


METHODS
The changes in serum levels of retinoids (vitamin A, alpha- and beta-carotene, alpha- and beta-cryptoxanthin, zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC) and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21 including 9 patients suffering from in situ colon cancer) cancer. Fifty-seven healthy subjects (in matched groups) for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.


RESULTS
The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of alpha- and beta-carotene, alpha- and beta-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.


CONCLUSIONS
Retinoids (as environmental factors) are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer.
Mózsik
Gyula
G
First Department of Medicine, Medical and Health Centre, University of Pecs, Hungary. gyula.mozsik@aok.pte.hu
Rumi
György
G
Dömötör
András
A
Figler
Mária
M
Gasztonyi
Beáta
B
Papp
Elod
E
Pár
Alajos
A
Pár
Gabriella
G
Belágyi
József
J
Matus
Zoltán
Z
Melegh
Béla
B
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood* / Q000235:genetics; D004938:Esophageal Neoplasms / Q000097:blood* / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000235:genetics; D017354:Point Mutation; D012176:Retinoids / Q000097:blood* / Q000502:physiology; D013274:Stomach Neoplasms / Q000097:blood* / Q000235:genetics; D014801:Vitamin A / Q000097:blood; D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene / Q000031:analogs & derivatives / Q000097:blood
D012176:Retinoids; D024341:Xanthophylls; D065146:Zeaxanthins; C095381:factor V Leiden; D019207:beta Carotene; D014801:Vitamin A; D005165:Factor V