title: Acid secretory potency and elimination of the 15-leucine gastrin-17 analogue in man.
abstract: The effect on gastric acid secretion and the elimination of a commercially available synthetic human gastrin analogue (15-Leucine Synthetic Human Gastrin I, 15-LSG) were studied in six healthy human subjects. On a molar basis acid secretory efficacy was approximately four times greater than pentagastrin and secretory potency ten times greater. Elimination of 15-LSG was bi-exponential, with half-lives of 5.2 +/- 0.8 and 25.9 +/- 7.0 min. Metabolic clearance rate was 6.9 +/- 0.4 ml/kg-min and volume of distribution 52 ml/kg.
authors.affiliation: Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Petersen
authors.forename: J
authors.initials: J
authors.lastname: Christiansen
authors.forename: J F
authors.initials: JF
authors.lastname: Rehfeld
mesh_terms: D000328:Adult; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012016:Reference Values; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D005755:Gastrins; C013550:gastrin 17