Histiocytic sarcoma associated with Hodgkin's disease.
Histiocytic sarcoma is a rare malignant neoplasm. It is well-known the association of Langerhans' cell histiocytosis with Hodgkin's disease but only few cases of histiocytic sarcoma associated with Hodgkin's disease was reported. We present the case of 20-years-old female patient with Hodgkin's disease with a sternal tumor mass which was diagnosed as histiocytic sarcoma. The diagnostic was established immunohistochemically, using a large battery of antibodies (S-100, CD 68, CD 34, CD 15, CD 30, Vim, NFAP) and by electron microscopy which revealed the lack of the Birbeck granules in the malignant proliferated histiocytes.
Murărescu
Elena Doina
ED
Department of Pathology, "Gr. T. Popa" University of Medicine and Pharmacy, Iassy. doinamurarescu@yahoo.com
Lighezan
Rodica
R
Negru
D
D
Chiseliţă
Irina Rodica
IR
Plămădeală
P
P
Mihailovici
Maria Sultana
MS
D000328:Adult; D005260:Female; D015620:Histiocytic Disorders, Malignant / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome