title: Lipid peroxidation and antioxidant status in stomach cancer.
abstract: BACKGROUND
  Considerable evidences have linked oxidative damage and cancer. In this article, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) activities, and malondialdehyde (MDA) and nitric oxide metabolites' levels (NO(x)) were investigated in patients with stomach cancer.
  
  
  METHODS
  All measurments were done by spectrophotometric techniques.
  
  
  RESULTS
  We observed a significant decrease in the activities of SOD and CAT in tumour tissues when compared with control tissues. The different of GSHPx activities and NO metabolite' levels were not statistically significant. MDA levels were significantly increased.
  
  
  CONCLUSIONS
  We conclude that increased MDA levels and decreased antioxidant enzyme activities can be valuable parameters in assessing the possible risk of cancer.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, Turkey. kadirbatci@inonu.edu.tr
authors.forename: Kadir
authors.initials: K
authors.lastname: Batcioglu
authors.forename: Nihayet
authors.initials: N
authors.lastname: Mehmet
authors.forename: I Cetin
authors.initials: IC
authors.lastname: Ozturk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Nurettin
authors.initials: N
authors.lastname: Aydogdu
authors.forename: Rezzan
authors.initials: R
authors.lastname: Erguvan
authors.forename: Burcin
authors.initials: B
authors.lastname: Uyumlu
authors.forename: Metin
authors.initials: M
authors.lastname: Genc
authors.forename: A Alev
authors.initials: AA
authors.lastname: Karagozler
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase