Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.
Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.
Bowen
Joanne M
JM
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia. joanne.bowen@adelaide.edu.au
Gibson
Rachel J
RJ
Cummins
Adrian G
AG
Keefe
Dorothy M K
DM
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017209:Apoptosis / Q000187:drug effects; D052160:Benzothiazoles / Q000494:pharmacology; D020169:Caspases / Q000096:biosynthesis / Q000187:drug effects / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D052016:Mucositis / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000187:drug effects / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013234:Stem Cells / Q000187:drug effects; D014050:Toluene / Q000031:analogs & derivatives / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000187:drug effects / Q000378:metabolism*
D000970:Antineoplastic Agents; D052160:Benzothiazoles; D019253:Proto-Oncogene Proteins c-bcl-2; D011837:Radiation-Protective Agents; D016159:Tumor Suppressor Protein p53; D014050:Toluene; C121565:pifithrin; D020169:Caspases