Oocyte-to-embryo transition: kinase cabal plots regime change.
The transition from oocyte to embryo is among the most enthralling events in developmental biology. Recent studies of this transition in the nematode Caenorhabditis elegans have revealed how conserved kinases administer the destruction of key oocyte meiotic regulators to create an embryo.
Greenstein
David
D
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. david.greenstein@vanderbilt.edu
Lee
Laura A
LA
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000196:embryology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000201:enzymology*; D005260:Female; D008540:Meiosis / Q000502:physiology*; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D009865:Oocytes / Q000201:enzymology*; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D009687:Nuclear Proteins; C440205:OMA-1 protein, C elegans; C100950:pie-1 protein, C elegans; C478059:MBK-2 protein, C elegans; D011505:Protein-Tyrosine Kinases; D018844:Cyclin-Dependent Kinases; D000251:Adenosine Triphosphatases; C086678:MEI-1 protein, C elegans