[Clinical-epidemiological study of patients with toxic liver diseases].
To evaluate effects of potentially hepatotoxic factors on the body we have studied medical histories of 3382 patients hospitalized at the toxicoresuscitation unit of the TSU Clinical Hospital and at the University Therapy Clinic of the City Hospital N1 during 2000-2004. It was found out that the most common etiologic causes of intoxication are medicines and alcohol. The role of chemical substances is also significant. The number of effect of other etiologic factors is lower. Intoxications due to potentially hepatotoxic agents by years were observed in 68.25%; 68.18%; 80.35%; 75.31%; 64.42% of cases of accidental drug-induced intoxication and in 55.00%; 59.32%; 52.03%; 53.33%; 69.09% of drug-induced suicidal cases and these drugs represented various pharmacologic groups. Intoxication with combined drugs occurs mainly in cases of suicide. Effect of organic and non-organic substances in accidental intoxications and suicidal cases are similar. According to the data of the National Center for Diseases Control the number of patients with toxic liver injury during 2000 to 2004 yy. accounts for 0.42%, 014%, 0.06%, 0.89%, 1.17% of patients discharged from Tbilisi hospitals with diagnosis of chronic liver disease and 0.81%; 1.12%; 1.19%; 1.07%; 1.23% of patients being under the supervision of outpatient clinics at the end of the year respectively, this does not reflect actual state based on the observed effects of potentially hepatotoxic medicines and chemical substances and requires from clinicians to pay more attention to this problem.
Dvali
M O
MO
Kandashvili
T I
TI
Gordeladze
D G
DG
D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000503:physiopathology*; D002908:Chronic Disease; D006801:Humans; D015994:Incidence; D012042:Registries