title: Self-assembly and characterization of layered double hydroxide/DNA hybrids.
abstract: The purpose of this study was to control the fabrication of new labile supramolecular assemblies by formulating associations of DNA molecules with inorganic layered double hydroxides (LDHs). The results show that LDH/DNA hybrids synthesized by a coprecipitation route involving the in situ formation of LDHs around DNA molecules acting as templates were characterized by a lamellar organization, with DNA molecules sandwiched between hydroxide layers, exhibiting a regular spacing of 1.96 nm. Our results indicate that labile complexes resulting from the association of nucleic acids and inorganic materials can be obtained not only by anion exchange but also by a direct self-assembly route.
authors.affiliation: Inserm U533, Faculté de Médecine, 1 rue Gaston Veil, 44000 Nantes, France.
authors.forename: Léa
authors.initials: L
authors.lastname: Desigaux
authors.forename: Malha Ben
authors.initials: MB
authors.lastname: Belkacem
authors.forename: Peggy
authors.initials: P
authors.lastname: Richard
authors.forename: Joël
authors.initials: J
authors.lastname: Cellier
authors.forename: Philippe
authors.initials: P
authors.lastname: Léone
authors.forename: Laurent
authors.initials: L
authors.lastname: Cario
authors.forename: Fabrice
authors.initials: F
authors.lastname: Leroux
authors.forename: Christine
authors.initials: C
authors.lastname: Taviot-Guého
authors.forename: Bruno
authors.initials: B
authors.lastname: Pitard
mesh_terms: D004247:DNA / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D033362:Powder Diffraction; D012680:Sensitivity and Specificity; D013499:Surface Properties
chemical_list: D006878:Hydroxides; D004247:DNA