Increased levels of soluble flt-3 ligand in serum and long-term bone marrow culture supernatants in patients with chronic idiopathic neutropenia.
The levels of serum and long-term bone marrow culture supernatant soluble flt-3 ligand (sFL) were determined in 54 patients with chronic idiopathic neutropenia (CIN) and 16 normal controls. Both serum and supernatant sFL levels were significantly increased in the patients compared with controls. Individual sFL values inversely correlated with the number of circulating neutrophils and the proportion of bone marrow CD34+ cells. Supernatant sFL values positively correlated with the levels of supernatant G-CSF. These findings suggest that the impaired myelopoiesis in CIN patients is accompanied by a compensatory mechanism attempting to increase the neutrophil production at the myeloid progenitor cell level.
Papadaki
Helen A
HA
Department of Haematology of the University of Crete School of Medicine, Heraklion, Crete, Greece. epapadak@med.uoc.gr
Damianaki
Athina
A
Pontikoglou
Charalampos
C
Pyrovolaki
Katerina
K
Eliopoulos
Dimitris G
DG
Stavroulaki
Emily
E
Eliopoulos
George D
GD
D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D002478:Cells, Cultured; D002908:Chronic Disease; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D009503:Neutropenia / Q000378:metabolism* / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D018709:Statistics, Nonparametric; D013997:Time Factors
D008565:Membrane Proteins; C084881:flt3 ligand protein; D016179:Granulocyte Colony-Stimulating Factor