title: Imaging of cerebral blood flow and metabolism in brain injury in the ICU.
abstract: The heterogeneity of the initial insult and subsequent pathophysiology has made both the study of human head injury and design of randomised controlled trials exceptionally difficult. The combination of multimodality bedside monitoring and functional brain imaging positron emission tomography (PET) and magnetic resonance (MR), incorporated within a Neurosciences Critical Care Unit, provides the resource required to study critically ill patients after brain injury from initial ictus through recovery from coma and rehabilitation to final outcome. Methods to define cerebral ischemia in the context of altered cerebral oxidative metabolism have been developed, traditional therapies for intracranial hypertension re-evaluated and bedside monitors cross-validated. New modelling and analytical approaches have been developed.
authors.affiliation: Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK. idpsecretary@medschl.can.ac.uk
authors.forename: J D
authors.initials: JD
authors.lastname: Pickard
authors.forename: P J
authors.initials: PJ
authors.lastname: Hutchinson
authors.forename: J P
authors.initials: JP
authors.lastname: Coles
authors.forename: L A
authors.initials: LA
authors.lastname: Steiner
authors.forename: A J
authors.initials: AJ
authors.lastname: Johnston
authors.forename: T D
authors.initials: TD
authors.lastname: Fryer
authors.forename: M R
authors.initials: MR
authors.lastname: Coleman
authors.forename: P
authors.initials: P
authors.lastname: Smielewski
authors.forename: D A
authors.initials: DA
authors.lastname: Chatfield
authors.forename: F
authors.initials: F
authors.lastname: Aigbirhio
authors.forename: G B
authors.initials: GB
authors.lastname: Williams
authors.forename: K
authors.initials: K
authors.lastname: Rice
authors.forename: J C
authors.initials: JC
authors.lastname: Clark
authors.forename: C H
authors.initials: CH
authors.lastname: Salmond
authors.forename: B J
authors.initials: BJ
authors.lastname: Sahakian
authors.forename: P G
authors.initials: PG
authors.lastname: Bradley
authors.forename: T A
authors.initials: TA
authors.lastname: Carpenter
authors.forename: R
authors.initials: R
authors.lastname: Salvador
authors.forename: A
authors.initials: A
authors.lastname: Pena
authors.forename: J H
authors.initials: JH
authors.lastname: Gillard
authors.forename: A S
authors.initials: AS
authors.lastname: Cunningham
authors.forename: S
authors.initials: S
authors.lastname: Piechnik
authors.forename: M
authors.initials: M
authors.lastname: Czosnyka
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation; D003422:Critical Care / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007362:Intensive Care Units; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D049268:Positron-Emission Tomography / Q000379:methods*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D006113:United Kingdom
chemical_list: D015415:Biomarkers; D010100:Oxygen