A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan.
OBJECTIVE
We compared the dose requirement and side effect profile of total intravenous anaesthesia using Diprivan to generic propofol at a specific anaesthetic target level utilizing the bispectral index monitor to determine efficacy differences between the two products.


METHODS
Sixty women undergoing abdominal hysterectomy were induced with propofol 2 mg kg-1 and maintained with infusion (20-200 microg kg-1 min-1) adjusted to maintain a bispectral index of 50-65. Plasma propofol concentration was measured at 1 and 2 h post induction in 25 patients.


RESULTS
Mean (SD) drug doses adjusted for weight and time were similar in the Diprivan and generic propofol groups: 90 (30) microg kg-1 min-1 vs. 90 (20) microg kg-1 min-1 respectively. Mean (SD) plasma propofol levels at 1 and 2 h were also similar (3.0 (1.0) microg mL-1 vs. 3.6 (1.4) microg mL-1, P = 0.2 and 3.0 (1.9) microg mL-1 vs. 3.4 (1.6) microg mL-1, P = 0.58).


CONCLUSIONS
Diprivan and generic propofol have similar efficacy at a specified, bispectral index-defined, depth of anaesthesia.
Olufolabi
A J
AJ
Duke University Medical Center, Department of Anesthesiology, Division of Women's Anaesthesia Research Group, Durham, NC 27710, USA. olufo001@mc.duke.edu
Gan
T J
TJ
Lacassie
H J
HJ
White
W D
WD
Habib
A S
AS
D000328:Adult; D004311:Double-Blind Method; D016568:Drugs, Generic / Q000494:pharmacology / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D013447:Sulfites / Q000494:pharmacology / Q000627:therapeutic use*
D016568:Drugs, Generic; D013447:Sulfites; D015742:Propofol