title: Development of a polar-embedded stationary phase with unique properties.
abstract: This paper describes a new polar-embedded stationary phase that contains an internal sulfonamide functional group coupled with an ether linkage. The synthesis involves functionalization of spherical silica particles with ligands prepared in a multi-step synthesis. The resulting material contains 16.5% carbon, corresponding to a ligand coverage of 2.4mumol/m(2). Chromatographic evaluations indicates that the new stationary phase exhibits lower polarity than any other polar-embedded packings investigated, with additional features such as low silanol activity, excellent compatibility with 100% aqueous mobile phases, higher shape selectivity for polycyclic aromatic hydrocarbons, and strong affinity to nitro-containing compounds.
authors.affiliation: Dionex Corporation, Sunnyvale, CA 94088, USA. xiaodong.liu@dionex.com
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liu
authors.forename: Andrei
authors.initials: A
authors.lastname: Bordunov
authors.forename: Mark
authors.initials: M
authors.lastname: Tracy
authors.forename: Rosanne
authors.initials: R
authors.lastname: Slingsby
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Avdalovic
authors.forename: Christopher
authors.initials: C
authors.lastname: Pohl
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009574:Nitro Compounds / Q000302:isolation & purification*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009574:Nitro Compounds; D013449:Sulfonamides