title: Histiocytic sarcoma associated with Hodgkin's disease.
abstract: Histiocytic sarcoma is a rare malignant neoplasm. It is well-known the association of Langerhans' cell histiocytosis with Hodgkin's disease but only few cases of histiocytic sarcoma associated with Hodgkin's disease was reported. We present the case of 20-years-old female patient with Hodgkin's disease with a sternal tumor mass which was diagnosed as histiocytic sarcoma. The diagnostic was established immunohistochemically, using a large battery of antibodies (S-100, CD 68, CD 34, CD 15, CD 30, Vim, NFAP) and by electron microscopy which revealed the lack of the Birbeck granules in the malignant proliferated histiocytes.
authors.affiliation: Department of Pathology, "Gr. T. Popa" University of Medicine and Pharmacy, Iassy. doinamurarescu@yahoo.com
authors.forename: Elena Doina
authors.initials: ED
authors.lastname: Murărescu
authors.forename: Rodica
authors.initials: R
authors.lastname: Lighezan
authors.forename: D
authors.initials: D
authors.lastname: Negru
authors.forename: Irina Rodica
authors.initials: IR
authors.lastname: Chiseliţă
authors.forename: P
authors.initials: P
authors.lastname: Plămădeală
authors.forename: Maria Sultana
authors.initials: MS
authors.lastname: Mihailovici
mesh_terms: D000328:Adult; D005260:Female; D015620:Histiocytic Disorders, Malignant / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome