title: Chemical constituents of the roots of Piper sarmentosum.
abstract: Sixteen compounds were isolated from the fresh roots of Piper sarmentosum. Seven of these have been previously isolated from the fruits and leaves of this plant: the aromatic alkene (1), 1-allyl-2-methoxy-4,5-methylenedioxybenzene (4), beta-sitosterol, pyrrole amide (6), sarmentine (10), sarmentosine (13) and pellitorine (14). (+)-Sesamin (2), horsfieldin (3), two pyrrolidine amides 11 and 12, guineensine (15) and brachystamide B (16) are new for P. sarmentosum. Sarmentamide A, B, and C (7-9) are new natural products. Compounds 1--4 and 6--16 were tested for antiplasmodial, antimycobacterial and antifungal activities.
authors.affiliation: Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand. pittayat@su.ac.th
authors.forename: Pittaya
authors.initials: P
authors.lastname: Tuntiwachwuttikul
authors.forename: Photchana
authors.initials: P
authors.lastname: Phansa
authors.forename: Yupa
authors.initials: Y
authors.lastname: Pootaeng-On
authors.forename: Walter Charles
authors.initials: WC
authors.lastname: Taylor
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D011759:Pyrrolidines; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000962:Antimalarials; D000995:Antitubercular Agents; D010936:Plant Extracts; D011759:Pyrrolidines; D011760:Pyrrolidinones; C509309:sarmentamide A; C509310:sarmentamide B; C509311:sarmentamide C