Economic assessment of a maintenance treatment strategy in prevention of recurrent depressive disorder.
OBJECTIVE
To compare the 12-month cost-effectiveness of milnacipran in maintenance treatment of depression to that of medical follow-up without antidepressant.


METHODS
A Markov model with transition probabilities from a double blind clinical trial demonstrating the prophylactic efficacy of milnacipran was used. Other parameters were obtained from published sources.


RESULTS
Base-case incremental cost for preventive treatment was 1,191 FF. It was reduced to 685 FF when using a 25% hospitalization rate in case of recurrence. Patients with a high initial response had extra cost of 191 FF and cost-utility was estimated to be 23,875 FF per QALY gained. For those patients, using a 25% hospitalization rate in case of recurrence, costs were lower at 1,174 FF and preventive strategy was dominating.


CONCLUSIONS
Cost of maintenance therapy is partially balanced by the gain from recurrence prevention. It should be focused on patients with few residual symptoms or a high probability of hospitalization in case of recurrence.
Dardennes
R M
RM
Centre Hospitalier Sainte-Anne, Paris, France.
Lafuma
A
A
Fagnani
F
F
Pribil
C
C
Bisserbe
J C
JC
Berdeaux
G
G