title: Endoscopic mucosal resection for early gastric cancer.
abstract: BACKGROUND
  The treatment of early gastric cancer (EGC) using an endoscopy, namely, endoscopic mucosal resection (EMR), has been adopted for about 20 years, but the effectiveness and the safety of the modality are still controversial. The quality of these trials has not been assessed systematically.
  
  
  OBJECTIVE
  The purpose of this review was to compare the effectiveness and the safety of EMR with gastrectomy for the treatment of EGC.
  
  
  METHODS
  Searches were conducted on the Cochrane Central Register of Controlled Trials - CENTRAL (which includes the Cochrane Upper Gastrointestinal and Pancreatic Diseases Group Trials Register) on The Cochrane Library (Issue 1 2005) MEDLINE (1966 to March 2005) and EMBASE (1980 to March 2005), CINAHL (1985-March 2005) and CBM (Chinese BioMedical Database 1982 -2002). Reference lists from trials selected by electronic searching were handsearched to identify further relevant trials. Published abstracts from conference proceedings from the United European Gastroenterology Week (published in Gut) and Digestive Disease Week (published in Gastroenterology) were handsearched. Members of the Cochrane UGPD Group, and experts in the field were contacted and asked to provide details of outstanding clinical trials and any relevant unpublished materials
  
  
  METHODS
  All randomised controlled trials of EGC patients involving a treatment arm of EMR and a comparison arm of gastrectomy were to be included, but no RCTs were found.
  
  
  METHODS
  Three reviewers (YP Wang, C Bennett and T Pan) independently assessed the eligibility of potential trials and extracted the data.
  
  
  RESULTS
  There are no included randomised control trials for the systematic review. Available evidence derived from non-randomised controlled trials is discussed in the main text of this review.
  
  
  CONCLUSIONS
  There is a lack of randomised controlled trials in which EMR is compared with gastrectomy for EGC. There is a need for well designed randomised controlled trials to determine the effects of EMR compared to gastrectomy.
authors.affiliation: West China Hospital of Sichuan University, Gasstroenterology, South Renmin Road, Chengdu, Sichuan, China, 610041. wyplm@mail.sc.cninfo.net
authors.forename: Y P
authors.initials: YP
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Bennett
authors.forename: T
authors.initials: T
authors.lastname: Pan
mesh_terms: D005743:Gastrectomy; D005753:Gastric Mucosa / Q000601:surgery*; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*