title: Chloride ion efflux from liposomes is controlled by sidechains in a channel-forming heptapeptide.
abstract: A suite of amphiphilic heptapeptides incorporating a glutamic acid derivative on the C-terminal side of a (Gly)(3)Pro sequence gives dramatically lower chloride ion release from liposomes when present in free carboxyl form rather than as an ester or amide.
authors.affiliation: Department of Chemistry, Washington University, 1 Brookings Drive, St. Louis, MO 63130, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: You
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ferdani
authors.forename: George W
authors.initials: GW
authors.lastname: Gokel
mesh_terms: D000577:Amides / Q000737:chemistry; D000595:Amino Acid Sequence; D002264:Carboxylic Acids / Q000737:chemistry; D018118:Chloride Channels / Q000737:chemistry* / Q000378:metabolism; D002712:Chlorides / Q000737:chemistry* / Q000378:metabolism; D004952:Esters / Q000737:chemistry; D018698:Glutamic Acid / Q000031:analogs & derivatives; D007477:Ions; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D004364:Pharmaceutical Preparations; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D011392:Proline / Q000737:chemistry; D011485:Protein Binding; D013997:Time Factors
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D018118:Chloride Channels; D002712:Chlorides; D004952:Esters; D007477:Ions; D008081:Liposomes; D009842:Oligopeptides; D004364:Pharmaceutical Preparations; D010743:Phospholipids; D018698:Glutamic Acid; D011392:Proline