Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.
The nortropane cocaine analogue, 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane (ZIENT), is a high affinity, selective serotonin transporter (SERT) ligand that has shown promise as a SERT imaging agent for single photon computed tomography (SPECT) when labeled with I-123. Synthesis of the labeling precursor, radiosynthesis of [(11)C]ZIENT, and in vivo evaluation in anesthetized and awake monkeys have been performed to determine the suitability of [(11)C]ZIENT as a PET agent for SERT imaging.
Plisson
Christophe
C
Department of Radiology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA.
Jarkas
Nachwa
N
McConathy
Jon
J
Voll
Ronald J
RJ
Votaw
John
J
Williams
Larry
L
Howell
Leonard L
LL
Kilts
Clinton D
CD
Goodman
Mark M
MM
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002250:Carbon Radioisotopes; D007553:Isotope Labeling; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D009662:Nortropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
C472792:2-carbomethoxy-3-(4'-(2-iodoethenyl)phenyl)nortropane; D002250:Carbon Radioisotopes; D009662:Nortropanes; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins