title: Single colon metastasis from breast cancer: a clinical case report.
abstract: Metastatic involvement of the extrahepatic digestive system is rare. We here report the case of a 62-year-old woman who presented with a bowel obstruction related to a metastasis of breast cancer occurring 12 years after a mastectomy for lobular carcinoma. No other distant metastases were detected except for two nodules of 20 and 5 mm on the right chest wall. Biopsy of the larger nodule showed a lobular carcinoma. The patient underwent a right hemicolectomy and then received chemotherapy combined with letrozole, resulting in a partial response. The literature revealed only a few cases of breast cancer metastatic to the colon. Patients with known breast cancer, particularly of the lobular histological type, who present with specific or less specific abdominal symptoms or signs such a microcytic anemia, should be endoscopically explored in order to detect possible metastases of the primary breast tumor.
authors.affiliation: Medical Oncology Unit, Department of Oncology-Hematology, Belcolle Hospital, Viterbo, Italy. Signorelli@oncologiaviterbo.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Signorelli
authors.forename: Donatella
authors.initials: D
authors.lastname: Pomponi-Formiconi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Nelli
authors.forename: Camillo Francesco
authors.initials: CF
authors.lastname: Pollera
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000150:complications / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D003082:Colectomy; D003110:Colonic Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology*; D000077289:Letrozole; D008875:Middle Aged; D009570:Nitriles / Q000008:administration & dosage; D035441:Thoracic Wall / Q000473:pathology; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage
chemical_list: D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole