Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume.
Ste20 serine/threonine kinases regulate fundamental cellular processes including the cell cycle, apoptosis, and stress responses. Recent studies in Caenorhabditis elegans and mammals demonstrate that Ste20 kinases also function in cell volume sensing and Cl- transport regulation. Yeast Ste20 initiates a shrinkage activated MAPK cascade that regulates organic osmolyte accumulation. Ste20 kinases thus play evolutionarily conserved roles in cellular volume sensing and regulation. They may also function in systemic osmotic homeostasis and to link cell-cycle events with cell volume.
Strange
Kevin
K
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. kevin.strange@vanderbilt.edu
Denton
Jerod
J
Nehrke
Keith
K
D000409:Alanine / Q000032:analysis; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D048429:Cell Size; D006706:Homeostasis; D006801:Humans; D017136:Ion Transport; D009419:Nerve Tissue Proteins / Q000502:physiology; D011392:Proline / Q000032:analysis; D011494:Protein Kinases / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction; D028021:Sodium-Potassium-Chloride Symporters / Q000502:physiology; D027981:Symporters / Q000502:physiology; D000096922:K Cl- Cotransporters; D000099317:Hippo Kinases
D000409:Alanine; D029742:Caenorhabditis elegans Proteins; D009419:Nerve Tissue Proteins; D011392:Proline; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D028021:Sodium-Potassium-Chloride Symporters; D027981:Symporters; D000096922:K Cl- Cotransporters; C108114:GCK-like kinase; C109163:STK24 protein, human; D000099317:Hippo Kinases