Preproghrelin Leu72Met polymorphism in obese Korean children.
Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.
Jo
Dae-Sun
DS
Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.
Kim
Se-Lim
SL
Kim
Sun-Young
SY
Hwang
Pyoung Han
PH
Lee
Kee-Hyoung
KH
Lee
Dae-Yeol
DY
D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006580:Genetic Carrier Screening; D054439:Ghrelin; D006801:Humans; D007723:Korea; D007930:Leucine / Q000235:genetics*; D008297:Male; D008715:Methionine / Q000235:genetics*; D009037:Motilin / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
D054439:Ghrelin; D014280:Triglycerides; D009037:Motilin; D002784:Cholesterol; D008715:Methionine; D007930:Leucine