Simmondsin for weight loss in rats.
OBJECTIVE
To investigate the safety and efficacy for weight loss of simmondsin, a dietary supplement extracted from the seed of the jojoba plant (Simmondsia chinensis).


METHODS
Sprague-Dawley male rats were fed various levels of simmondsin for 8 weeks (lean rats) or 16 weeks (high fat-induced obese rats).


METHODS
Food intake, body weight and composition, histopathology, hematology parameters.


RESULTS
Simmondsin produced a clear dose-response effect on food intake and body weight. No remarkable histopathologic changes were noted in the liver, kidney and spleen. One lean animal, in the 0.5% group, had approximately a 20% depression in red bone marrow cells. Significant effects on hematology parameters were seen almost exclusively in groups consuming simmondsin at the highest level (0.5%) and these effects appeared to be reversed by removing simmondsin from the diet.


CONCLUSIONS
Simmondsin at both the 0.15% level and the 0.25% level significantly reduced food intake and body weight without apparent negative effects. At dose levels much higher than therapeutic levels, there seemed to be reversible effects on circulating red and white blood cells. Future studies should determine long-term effects of lower doses on blood cell parameters.
Boozer
C N
CN
Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital Center, New York 10025, USA. cnb7@columbia.edu
Herron
A J
AJ
D000097:Acetonitriles / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage / Q000627:therapeutic use*; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003510:Cyclohexanes / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects; D005960:Glucosides / Q000008:administration & dosage / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007962:Leukocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013851:Thinness / Q000097:blood / Q000503:physiopathology; D015431:Weight Loss / Q000187:drug effects*
D000097:Acetonitriles; D001067:Appetite Depressants; D003510:Cyclohexanes; D005960:Glucosides; C089377:simmondsin