title: [A male case of acute sarcoidosis with fever, polyarthralgia, erythema nodosum, and bilateral hilar lymphadenopathy: Löfgren's syndrome].
abstract: A 27-year-old man initially had low back pain and ankle arthralgia. He was admitted because fever, cough, and polyarthralgia developed and continued for three months. Chest X-ray and CT revealed bilateral hilar and mediastinal lymphadenopathy with pulmonary lesions. Furthermore, elevated serum-ACE level and noncaseating epitheloid cell granuloma obtained by TBLB confirmed the diagnosis of sarcoidosis. After hospitalization, erythema nodosum appeared and ocular involvement was demonstrated. As a result, this case fulfilled the criteria of Löfgren's syndrome (arthritis, erythema nodosum, and BHL). Löfgren's syndrome is not uncommon in European countries, but is extremely rare in Japan. So far, only six cases with Löfgren's syndrome were reported in Japan, and all were female cases. This is the first male case in Japan. Löfgren's syndrome is usually a self-limiting disease. We used steroids for this case and remission has been maintained after the beginning of the treatment for the past one year.
authors.affiliation: Department of Internal Medicine, Tokyo Rosai Hospital.
authors.forename: Mayu
authors.initials: M
authors.lastname: Izumo
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sekiya
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Sakai
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tojima
mesh_terms: D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D018771:Arthralgia / Q000175:diagnosis* / Q000188:drug therapy; D004893:Erythema Nodosum / Q000175:diagnosis* / Q000188:drug therapy; D005334:Fever / Q000209:etiology; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D013577:Syndrome
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone