title: [MRI-intracranial compliance analysis in patients with NPH].
abstract: We devised a method for non-invasively assessing intracranial compliance with retrospective ECG-triggered phase contrast cine MRI. This method was examined in patients with normal pressure hydrocephalus (NPH) group and those with asymptomatic ventricular dilation or brain atrophy (VD group), and in healthy volunteers (control group). Intracranial volume change (DeltaV(max)) was calculated from arterial inflow, venous outflow, cerebrospinal fluid (CSF) flow, and spinal cord motion at the C2 level during a cardiac cycle. Next, craniospinal CSF pressure gradient change (DeltaPG(max)) was calculated from measured CSF flow velocity using a simplified Navier-Stokes equation. Finally, Ci was obtained by dividing Delta V(max) into DeltaPG(max). Ci in the NPH group was significantly smaller and could be differentiated from other groups. This method makes it possible to non-invasively obtain a more detailed determination of the intracranial state and dynamics in NPH and to assist in its diagnosis.
authors.affiliation: Division of Health Sciences, Graduate School of Medical Science, Kanazawa University.
authors.forename: Sayoko
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Tosiaki
authors.initials: T
authors.lastname: Miyati
authors.forename: Mitsuhito
authors.initials: M
authors.lastname: Mase
authors.forename: Harumasa
authors.initials: H
authors.lastname: Kasai
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nakajima
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Mori
authors.forename: Fujio
authors.initials: F
authors.lastname: Kawamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Masaki
authors.initials: M
authors.lastname: Hara
authors.forename: Yuta
authors.initials: Y
authors.lastname: Shibamoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003187:Compliance; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged