T lineage progenitors: the earliest steps en route to T lymphocytes.
T lymphocyte development in the thymus is a tightly regulated stepwise process. The identification and characterization of the earliest T lineage progenitors and their downstream progeny now enables the study of important cellular and molecular mechanisms that control and regulate T lineage commitment and differentiation. Significant progress has been made recently on the developmental relationships of the various cells with T cell progenitor activity identified in mouse bone marrow, blood and thymus, and on the molecular regulation of progenitor homing to the thymus. The essential role of Notch-1 signalling in intrathymic T lineage commitment and subsequent T cell development has been clearly documented.
Wu
Li
L
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria, 3050, Australia. wu@wehi.edu.au
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D051379:Mice; D051881:Receptor, Notch1 / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
C497762:Notch1 protein, mouse; D051881:Receptor, Notch1