title: Regulatory T cell-mediated transplantation tolerance.
abstract: The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4(+)CD25(+) T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Ankit
authors.initials: A
authors.lastname: Bharat
authors.forename: Ryan Courtney
authors.initials: RC
authors.lastname: Fields
authors.forename: T
authors.initials: T
authors.lastname: Mohanakumar
mesh_terms: D000818:Animals; D001989:Bronchiolitis Obliterans / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology*; D023001:Transplantation Tolerance / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; D015375:Receptors, Interleukin-2