title: Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate.
abstract: Sarcomatoid carcinomas of the prostate are rare malignancies composed of carcinomatous and sarcomatous elements. Their etiology is uncertain and may represent a single malignant process or a mixture of two distinct malignancies. We report a clinical case of a patient who presented with locally advanced disease and was treated with hormonal and cytotoxic chemotherapy, but ultimately developed distant metastasis and died of the disease. A loss-of-heterozygosity analysis of the primary and metastatic tissues provided compelling evidence that the carcinomatous and sarcomatous elements are clonally related, supporting the hypothesis that a single malignant process underlies the etiology of sarcomatoid carcinoma of the prostate.
authors.affiliation: Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA. mray@umich.edu
authors.forename: Michael E
authors.initials: ME
authors.lastname: Ray
authors.forename: Kirk J
authors.initials: KJ
authors.lastname: Wojno
authors.forename: Neal S
authors.initials: NS
authors.lastname: Goldstein
authors.forename: Karin B
authors.initials: KB
authors.lastname: Olson
authors.forename: Rajal B
authors.initials: RB
authors.lastname: Shah
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Cooney
mesh_terms: D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology*; D012509:Sarcoma / Q000235:genetics / Q000473:pathology