An exploration of sex-specific linkage disequilibrium on chromosome X in Caucasians from the COGA study.
This paper explores the decay of linkage disequilibrium (LD) on the autosomes and chromosome X. The extent of marker-marker LD is important for both linkage and association studies. The analysis of the Caucasian sample from the Collaborative Study on the Genetics of Alcoholism study revealed the expected negative relationship between the magnitude of the marker-marker LD and distance (cM), with the male and female subgroups exhibiting similar patterns of LD. The observed extent of LD in females was less across the pseudoautosomal markers relative to the heterosomal region of chromosome X. Marked differences in LD patterns were also observed between chromosomes X and the 22 autosomes in both males and females.
Cox
Miranda E
ME
Section on Biostatistics, Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. micox@wfubmc.edu
Campbell
Joel K
JK
Langefeld
Carl D
CD
D000437:Alcoholism / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D003299:Cooperative Behavior; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D012727:Sex Characteristics; D044465:White People / Q000235:genetics*