title: Malignant lymphoma in a West Indian manatee (Trichechus manatus).
abstract: We identified a malignant lymphoma infiltrating the lung, liver, kidney, mesenteric lymph nodes, and eye as the cause of death in a male West Indian manatee (Trichechus manatus). Diagnosis was based on gross, histopathologic, and immunohistochemical studies. Tissue samples from ten organs were included in a tissue microarray and sections from this array were subjected to immunohistochemical staining. The cytoplasm of the neoplastic lymphocytes identified in six organs was positive for CD3, a marker for T-cell differentiation. The neoplastic cells were negative for CD79alpha, a marker for B-cell differentiation. The cause of this neoplasm was not determined. This is the first report of malignant lymphoma in the mammal order Sirenia.
authors.affiliation: Danish Institute for Food and Veterinary Research, 2 Hangoevej, DK-8200 Aarhus, Denmark. ash@dfvf.dk
authors.forename: Anne S
authors.initials: AS
authors.lastname: Hammer
authors.forename: Bjarne
authors.initials: B
authors.lastname: Klausen
authors.forename: Steffen
authors.initials: S
authors.lastname: Knold
authors.forename: Hans H
authors.initials: HH
authors.lastname: Dietz
authors.forename: Stephen J Hamilton
authors.initials: SJ
authors.lastname: Dutoit
mesh_terms: D000818:Animals; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008223:Lymphoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009928:Organ Specificity; D020457:Trichechus manatus