title: Steroidal glycosides from the underground parts of Solanum sodomaeum.
abstract: A new steroidal glycoside has been isolated from the underground parts of Solanum sodomaeum L., along with seven known steroidal glycosides. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence, and the structure of one known pregnane type glycoside was corrected. In addition, their antiproliferative activity against human promyelocytic leukemia (HL-60) cells was investigated, and five compounds exhibited stronger activity than cisplatin.
authors.affiliation: School of Agriculture, Kyushu Tokai University, Kumamoto, Japan. mono@kmail.ktokai-u.ac.jp
authors.forename: Masateru
authors.initials: M
authors.lastname: Ono
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nishimura
authors.forename: Keita
authors.initials: K
authors.lastname: Suzuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukushima
authors.forename: Keiji
authors.initials: K
authors.lastname: Igoshi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshimitsu
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D006868:Hydrolysis; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry; D032322:Solanum / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D013256:Steroids; D002945:Cisplatin