Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure.
This article summarizes the proceedings of a symposium presented at the 2005 annual meeting of the Research Society on Alcoholism in Santa Barbara, California, USA. The organizer and chair was L. Judson Chandler. The presentations were (1) Chronic Ethanol Exposure, N-Methyl-D-Aspartate (NMDA) Receptor Dynamics, and Withdrawal Hyperexcitability, by Adam Hendricson, Regina Maldve, and Richard Morrisett; (2) Ethanol-Induced Synaptic Targeting of NMDA Receptors Is Associated With Enhanced Postsynaptic Density-95 Clustering and Spine Size, by Judson Chandler and Ezekiel Carpenter-Hyland; (3) Presynaptic and Postsynaptic Alterations in the Nucleus Accumbens Following Chronic Alcohol Exposure, by Feng Zhou, Youssef Sari, and Richard Bell; and (4) An Active Role for Accumbens Homer2 Expression in Alcohol-Induced Neural Plasticity, by Karen Szumlinski.
Chandler
L Judson
LJ
Alcohol Research Center and Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA. chandj@musc.edu
Carpenter-Hyland
Ezekiel
E
Hendricson
Adam W
AW
Maldve
Regina E
RE
Morrisett
Richard A
RA
Zhou
Feng C
FC
Sari
Youssef
Y
Bell
Richard
R
Szumlinski
Karen K
KK
D000430:Alcohol Withdrawal Delirium / Q000503:physiopathology; D000437:Alcoholism / Q000503:physiopathology*; D000679:Amygdala / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001931:Brain Mapping; D002352:Carrier Proteins / Q000502:physiology; D000431:Ethanol / Q000633:toxicity*; D018698:Glutamic Acid / Q000502:physiology; D000072233:Homer Scaffolding Proteins; D006801:Humans; D051379:Mice; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; C000606625:Homer2 protein, mouse; C000606626:Homer2 protein, rat; D016194:Receptors, N-Methyl-D-Aspartate; D000431:Ethanol; D018698:Glutamic Acid