title: The frequency of chromosomal abnormalities in patients with reproductive failure.
abstract: OBJECTIVE
  To investigate the ratio of chromosomal abnormalities in recurrent fetal wastage.
  
  
  METHODS
  We conducted a study of the cytogenetic data of 645 couples (1290 patients) with recurrent fetal wastage examined at the Department of Medical Biology and Genetics, Trabzon, Turkey. Couples who had first trimester miscarriages/abortion, preceded or followed by a second or third trimester fetal death/fetal abnormalities were recruited from Obstetrics and Gynecology Clinics for cytogenetics analysis.
  
  
  RESULTS
  Chromosome abnormalities were found in 25 (3.86%) patients. The chromosomal abnormalities were structural (3.71%) and numerical (0.15%). Polymorphisms of heterochromatin blocks and inv(9) were shown in 115 (17.51%) patients.
  
  
  CONCLUSIONS
  Chromosome analyses are an important and necessary part of the etiological research in couples with recurrent fetal wastage.
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Medical Biology and Genetics, Trabzon, Turkey. gencelep@yahoo.com
authors.forename: Figen
authors.initials: F
authors.lastname: Celep
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karagüzel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozeren
authors.forename: Hasan
authors.initials: H
authors.lastname: Bozkaya
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D003582:Cytogenetics; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014178:Translocation, Genetic; D014421:Turkey / Q000453:epidemiology