A cautionary tale: fatal outcome of methotrexate therapy given for management of ectopic pregnancy.
BACKGROUND
Medical therapy with methotrexate is a standard practice for the commonly encountered problem of ectopic pregnancy. Methotrexate is excreted predominantly by the kidney and should be used with extreme caution in renal insufficiency. All physicians who administer methotrexate must understand its mechanism of action, distribution, and elimination to minimize potential risks to the patient.


METHODS
A young, dialysis-dependent woman received a standard dose of methotrexate for an ectopic pregnancy. Prolonged methotrexate exposure resulted. The consequences-pancytopenia, desquamation, acute respiratory distress syndrome, and profound bowel ischemia-ultimately led to her death.


CONCLUSIONS
Methotrexate, even at extremely low doses, can be fatal in patients with renal insufficiency. Alternative means of therapy should be sought for women with ectopic pregnancy and renal failure.
Kelly
Hanna
H
Department of Medicine, Division of Hematology-Oncology, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599, USA. hkelly@med.unc.eu
Harvey
Donald
D
Moll
Stephan
S
D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects*; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*
D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate