title: [The mechanism of bone resorption in chronic inflammation of periodontal disease].
abstract: Periodontal disease is caused by infections with oral periodontitis-associated microorganisms. Virulence factors like lipopolysaccharide (LPS) from those microorganisms initiate host immune response and gingival chronic inflammation. As a result, elevated receptor activator of NF-kappaB ligand (RANKL) expression stimulates alveolar bone resorption followed by loss of teeth.
authors.affiliation: Department of Periodontology, School of Dentistry, Aichi-Gakuin University.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Akio
authors.initials: A
authors.lastname: Mitani
authors.forename: Toshihide
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology* / Q000628:therapy; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D010510:Periodontal Diseases / Q000503:physiopathology*; D037521:Virulence Factors / Q000502:physiology
chemical_list: D008070:Lipopolysaccharides; D037521:Virulence Factors