title: Efficacy of telavancin against penicillin-resistant pneumococci and Staphylococcus aureus in a rabbit meningitis model and determination of kinetic parameters.
abstract: The penetration of telavancin was 2% into inflamed meninges and ca. 1 per thousand into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.
authors.affiliation: Department of Internal Medicine, Inselspital, Bern, Switzerland.
authors.forename: Armin
authors.initials: A
authors.lastname: Stucki
authors.forename: Peter
authors.initials: P
authors.lastname: Gerber
authors.forename: Fernando
authors.initials: F
authors.lastname: Acosta
authors.forename: Marianne
authors.initials: M
authors.lastname: Cottagnoud
authors.forename: Philippe
authors.initials: P
authors.lastname: Cottagnoud
mesh_terms: D000617:Aminoglycosides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000077427:Lipoglycopeptides; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; C487637:telavancin