title: Effect of plant stanol tablets on low-density lipoprotein cholesterol lowering in patients on statin drugs.
abstract: The objective of this study was to show that plant sterols in tablet form provide additional low-density lipoprotein (LDL) cholesterol lowering for patients on statin therapy. Dispersible phytosterol tablets were tested in a double-blind, placebo-controlled, parallel clinical trial. Twenty-six patients who were following the American Heart Association Heart Healthy Diet and on long-term statin therapy were studied for 9 weeks. After 3 weeks of placebo treatment, the subjects were randomized to receive either 1.8 g of soy stanols or placebo for 6 weeks in addition to their usual statin regimen. Stanol tablets reduced LDL cholesterol 9.1% (p = 0.007) or 12.2 mg/dl. Total cholesterol was reduced by 12.9 mg/dl (p = 0.03). A strong inverse correlation (r(s) = -0.82, p = 0.0007) was found between the baseline LDL cholesterol and the percent change in LDL cholesterol observed after stanol treatment. The additional LDL cholesterol lowering with stanol/lecithin tablets provided a potential adjunctive therapy for patients who have not reached their target LDL cholesterol goal during statin therapy.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Anne C
authors.initials: AC
authors.lastname: Goldberg
authors.forename: Richard E
authors.initials: RE
authors.lastname: Ostlund
authors.forename: Joyce H
authors.initials: JH
authors.lastname: Bateman
authors.forename: Linda
authors.initials: L
authors.lastname: Schimmoeller
authors.forename: Timothy B
authors.initials: TB
authors.lastname: McPherson
authors.forename: Curtis A
authors.initials: CA
authors.lastname: Spilburg
mesh_terms: D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood*; D004311:Double-Blind Method; D004338:Drug Combinations; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000627:therapeutic use; D010840:Phytosterols / Q000627:therapeutic use*; D013607:Tablets
chemical_list: D008078:Cholesterol, LDL; D004338:Drug Combinations; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D010713:Phosphatidylcholines; D010840:Phytosterols; D013607:Tablets