Lipid peroxidation and antioxidant enzyme status in oral carcinoma patients.
OBJECTIVE
To measure the lipid peroxidation and endogenous antioxidant enzyme status in oral carcinoma and the protective role of exogenous antioxidants.


METHODS
20 new cases of histologically proven oral squamous cell carcinoma, 20 of leukoplakia and 20 age and sex matched healthy conrols were included. Intra oral pH of patients and controlled were measured by quantitative litmus paper test and serum was analysed for malonialdehyde (MDA), super oxide bismutase (SOD), catalase and glutathione peroxidase (GP). Patients with leukoplakia were treated with exogenous antioxidants for 3 months and the same were reassessed.


RESULTS
Oral pH of oral cancer patients was neutral (PH-7) but that of leukoplakia and controls were mildly acidic (6.64 and 6.58 respectively). Serum malonialdehyde levels were highest in oral cancer group. With antioxidant enzymes super oxide bismutase, catalase and glutathione peroxidase different pattern was noticed. Antioxidant enzymes remained almost the same (P > 0.005 each) in patients with leukoplakia after 3 months of vitamin A,C and E. but there was marginal increase in catalase level (P<0.05).


CONCLUSIONS
This study shows the positive benefit of vitamin (A,C,E) and nutrition supplementation on the antioxidant enzyme defense system hence prevention of oral carcinogenesis in patients with leukoplakia.
Khanna
R
R
Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. drrahulkhanna@rediffmail.com
Thapa
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D000975:Antioxidants / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000201:enzymology; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007971:Leukoplakia / Q000201:enzymology; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism; D009062:Mouth Neoplasms / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D011230:Precancerous Conditions / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D008315:Malondialdehyde; D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase