title: Intraneuronal trafficking of G-protein-coupled receptors in vivo.
abstract: In vitro studies have widely demonstrated that the abundance and availability of G-protein-coupled receptors (GPCRs) at the cell surface is regulated by the neuronal environment and is the result of complex intraneuronal trafficking. However, this regulation is still poorly understood in vivo. Modulation of receptor availability at the neuronal membrane is a key event in the regulation of neuronal functions (e.g. neurotransmitter release or neuronal excitability in physiological, pathological or therapeutic conditions). We discuss the effects of duration of receptor stimulation (acute versus chronic) on the intraneuronal trafficking of GPCRs in vivo, and we show that this trafficking might differ according to subcellular compartment (soma, dendrites or axon terminals).
authors.affiliation: Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5541, Laboratoire d'Histologie-Embryologie, Université Victor Ségalen-Bordeaux 2, 146 Rue Léo-Saignat, 33076 Bordeaux Cedex, France. veronique.bernard@univ-paris5.fr
authors.forename: Véronique
authors.initials: V
authors.lastname: Bernard
authors.forename: Marion
authors.initials: M
authors.lastname: Décossas
authors.forename: Isabel
authors.initials: I
authors.lastname: Liste
authors.forename: Bertrand
authors.initials: B
authors.lastname: Bloch
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D015536:Down-Regulation; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D021381:Protein Transport; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013194:Staining and Labeling / Q000379:methods
chemical_list: D018377:Neurotransmitter Agents; D043562:Receptors, G-Protein-Coupled