title: The efficacy of a single-oral-dose administration of ivermectin and diethylcarbamazine on the treatment of feline Brugia malayi.
abstract: The combination of ivermectin and diethylcarbamazine (DEC) have been shown to be superior to either drug alone for the suppression of Brugia malayi in humans, but their efficacy against infection with B. malayi in cats has never been investigated. Fourteen asymptomatic microfilaremic (1-200 microfilariae/20 microl blood) cats received oral doses of ivermectin (400 microg/kg body weight) and DEC (6 mg/kg body weight) as a single treatment. A two-month post-treatment examination revealed that 87-100% of the microfilariae in each subject had been cleared, with two of the subjects being amicrofilaremic. A further reduction in microfilarial levels was observed until the final follow-up, at 8 months post-treatment, when the mean clearance rate was 99% and 12 out of the 14 subjects (86%) were amicrofilaremic. The combination of ivermectin and DEC demonstrated a microfilaricidal effect superior to that of either drug used alone, both in the initial rapid clearance of microfilariae, and in sustaining the effect for 8 months. This finding has important implications for the control of brugian lymphatic filariasis in the cat reservoir.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Prathom, Thailand.
authors.forename: Gaysorn
authors.initials: G
authors.lastname: Chansiri
authors.forename: Phaisan
authors.initials: P
authors.lastname: Khawsak
authors.forename: Sirichai
authors.initials: S
authors.lastname: Phantana
authors.forename: Nopporn
authors.initials: N
authors.lastname: Sarataphan
authors.forename: Kosum
authors.initials: K
authors.lastname: Chansiri
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001483:Base Sequence; D017178:Brugia malayi / Q000187:drug effects*; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D017931:DNA Primers; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005368:Filariasis / Q000188:drug therapy / Q000662:veterinary*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013785:Thailand; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D017931:DNA Primers; D007559:Ivermectin; D004049:Diethylcarbamazine