title: Dural plasmacytoma mimicking meningioma in a patient with multiple myeloma.
abstract: Apart from calvarial infiltration, intracranial involvement in multiple myeloma is uncommon. Diffuse leptomeningeal invasion with or without parenchymal involvement is most common. Dural infiltration without involvement of the parenchyma, leptomeninges or skull is rare. The differential diagnosis of a dural plasmacytoma includes meningioma, which has a similar MRI appearance, metastasis, lymphoma and sarcoma of the dura mater. We present a patient with multiple myeloma presenting with an intracerebral mass mimicking a meningioma on MRI. Multiple myeloma had been diagnosed seven years previously. The patient presented with headache and speech disturbance 12 months after autologous peripheral stem cell transplantation for recurrence of multiple myeloma. MRI revealed a left temporal extra-axial mass with a dural tail mimicking meningioma. Histopathological examination of the mass after excision showed multiple myeloma immunopositive for IgG, kappa light chain and CD38. There was no recurrence after postoperative radiotherapy. Plasmacytoma should be considered in the differential diagnosis of a solitary dural mass, particularly in a patient with multiple myeloma.
authors.affiliation: Department of Hematology, Ege University School of Medicine, Bornova 35100, Izmir, Turkey. fsahin@med.ege.edu.tr
authors.forename: Fahri
authors.initials: F
authors.lastname: Sahin
authors.forename: Guray
authors.initials: G
authors.lastname: Saydam
authors.forename: Yesim
authors.initials: Y
authors.lastname: Ertan
authors.forename: Cem
authors.initials: C
authors.lastname: Calli
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dönmez
authors.forename: Murat
authors.initials: M
authors.lastname: Tombuloglu
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D010954:Plasmacytoma / Q000175:diagnosis* / Q000473:pathology; D013064:Speech Disorders / Q000209:etiology
chemical_list: D007074:Immunoglobulin G; D051997:ADP-ribosyl Cyclase 1