title: Incidence of monoclonal B-cell disease in siblings of patients with multiple myeloma.
abstract: We observed clustering of monoclonal B-cell disease in siblings being screened as allogeneic donors for patients with multiple myeloma (MM) scheduled for stem cell transplantation (SCT). Of 134 asymptomatic donors, the incidence of monoclonal B-cell disease was 8/84 in siblings and 1/50 in matched unrelated donors. From an analysis of five MM families scheduled for allogeneic SCT, monoclonal B-cell disease was detected in 8/27 siblings.
authors.forename: Monika
authors.initials: M
authors.lastname: Engelhardt
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ihorst
authors.forename: Dirk
authors.initials: D
authors.lastname: Behringer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Finke
authors.forename: Birgit
authors.initials: B
authors.lastname: Roth
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology*; D002999:Clone Cells / Q000473:pathology; D005192:Family Health; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D009101:Multiple Myeloma / Q000473:pathology*; D035781:Siblings; D014019:Tissue Donors