Chromosomal abnormalities in patients with azoospermia in Western Mexico.
In order to assess the frequency of chromosomal abnormalities in azoospermic males from western Mexico, we carried out a retrospective study in 227 patients. Forty-three (18.9%) cases with an abnormal karyotype were found. The most frequent chromosomal anomaly was 47,XXY, which was identified in 35 subjects (15.4%). In six cases (2.6%), structural aberrations were detected: two Robertsonian translocations [(45,XY,t(13;22)(p11;p11) and (45,XY,t(13;15)(p11;p11)], a Y;autosome translocation [46,XY,der(15)t(Y;15)(q12;p11)], and three mosaics [mos45,X/46,X,idic(Y)(q11)]. In general, these findings are in accordance with those from other surveys and confirm that the XXY aneuploidy is the most frequent chromosomal abnormality in azoospermic individuals.
Meza-Espinoza
J P
JP
Facultad de Medicina, Unidad Académica de Ciencias de la Salud y Tecnología, Universidad Autónoma de Tamaulipas, Matamoros, Tamaulipas, Mexico.
Davalos-Rodríguez
I P
IP
Rivera-Ramírez
H
H
Perez-Muñoz
S
S
Rivas-Solís
F
F
D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000453:epidemiology*; D006801:Humans; D007713:Klinefelter Syndrome / Q000453:epidemiology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009845:Oligospermia / Q000235:genetics*; D012189:Retrospective Studies