title: [Nutritional status, pulmonary functions, and exercise performance in COPD cases].
abstract: The aim of this study was evaluation of nutritional status in attack and stable chronic obstructive pulmonary disease (COPD) cases, and investigating the relation between nutrition parameters and pulmonary functions, exercise performance and general healthy status. Anthropometric measures of 10 cases with attack (group 1), 14 stabilized COPD cases (group 2) and 10 control cases (group 3) were evaluated by measuring serum albumin, transferrin, tumor necrosis factor-alpha (TNF-alpha) levels, and fat-free mass (FFM) levels. Six minutes walking test (mwt) and SGRQ questionnaire were performed. Body mass index (BMI) of group 1 and 2 were significantly lower than group 3 (p= 0.023, p= 0.008, respectively). Albumin levels were significantly lower in group 1 than group 2 (p< 0.001) and 3 (p= 0.001). Levels of transferrin were significantly lower in group 1 compared with group 3 (p= 0.015). TNF-alpha levels were significantly high in group 1 compared with group 2 (p= 0.002), and high in group 2 compared with group 3 (p= 0.001). FFM was significantly low in group 1 compared with group 2 (p= 0.003), and low in group 2 compared with group 3 (p< 0.001). Mean distance of 6 mwt was 225.80 +/- 40.35 m in group 1, it was 405.16 +/- 95.51 m in group 2 (p< 0.001). A positive relation was seen between FFM and BMI, 6 mwt (p= 0.006, r= 0.481 ve p< 0.001, r= 0.830, respectively), between albumin levels and 6 mwt (p< 0.001, r= 0.850). A negative correlation was observed between TNF-alpha and 6 mwt (p< 0.001, r= -0.745). There was no statistical difference in antropometric measures between groups. Total score and daily life were statistically high in group 1 than group 2 (p= 0.009, p= 0.013). Although no changes was seen in antropometric measures of COPD cases, a nutritional defect was seen and a significant relation was observed between nutrition parameters and effort capacity.
authors.affiliation: Department of Chest Disease, Faculty of Medicine, Firat University, Elaziğ, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Deveci
authors.forename: Tuncer
authors.initials: T
authors.lastname: Tuğ
authors.forename: Teyfik
authors.initials: T
authors.lastname: Turgut
authors.forename: Murat
authors.initials: M
authors.lastname: Ogetürk
authors.forename: Gamze
authors.initials: G
authors.lastname: Kirkil
authors.forename: Canan
authors.initials: C
authors.lastname: Kaçar
authors.forename: M Hamdi
authors.initials: MH
authors.lastname: Muz
mesh_terms: D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism; D012720:Severity of Illness Index; D014168:Transferrin / Q000032:analysis / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D014168:Transferrin; D014409:Tumor Necrosis Factor-alpha