Spontaneous resolution of systemic sarcoidosis in a patient with chronic hepatitis C without interferon therapy.
A 39-year-old male patient complaining of bilateral hand joint arthralgia was evaluated and found to have chronic hepatitis C and systemic sarcoidosis involving lung, skin, liver, and spleen. Hepatic and cutaneous sarcoidoses were confirmed by the presence of numerous noncaseating granulomas on histological examination. Pulmonary and splenic involvements were diagnosed by imaging studies. Fifteen months later, the sarcoidotic lesions in lung, liver, and spleen were resolved by radiological studies and a liver biopsy showed no granuloma but moderate to severe inflammatory activity. systemic sarcoidosis is a rare comorbidity of chronic hepatitis C which may spontaneously resolve.
Kim
Tae-Hun
TH
Department of Internal Medicine and Medical Research Institute, Ewha Womans University Hospital, 911-1 Mok-Dong, Yangchun-Gu, Seoul 158-710, Mokdong South Korea. thkm@ewha.ac.kr
Joo
Jong-Eun
JE
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008297:Male; D012507:Sarcoidosis / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D018417:Th1 Cells / Q000276:immunology
D000305:Adrenal Cortex Hormones; D007372:Interferons