title: [Preoperative sedation with dexmedetomidine in patients with aneurysmal subarachnoid hemorrhage].
abstract: BACKGROUND
  Dexmedetomidine could be beneficial for preoperative sedation of patients with aneurysmal subarachnoid hemorrhage (SAH) because of its sympathetic suppressive effect without respiratory depression.
  
  
  METHODS
  Thirteen patients were sedated with continuous intravenous administration of dexmedetomidine (group D) and 13 were with intermittent intravenous administration of diazepam and pentazocine (group C).
  
  
  RESULTS
  Blood pressure (BP) and heart rate (HR) on admission to OR in group D were lower than those in group C. On tracheal intubation, BP and HR increased in both groups, but the differences between the values before and after the intubation were larger in group C than in D.
  
  
  CONCLUSIONS
  Preoperative dexmedetomidine infusion is suitable for patients with SAH.
authors.affiliation: Department of Neuroanesthesia, Kohnan Hospital, Sendai 982-8523.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Sato
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kamii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Masato
authors.initials: M
authors.lastname: Kato
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General; D016292:Procedural Sedation; D020927:Dexmedetomidine / Q000008:administration & dosage*; D003975:Diazepam / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010423:Pentazocine / Q000008:administration & dosage; D011229:Preanesthetic Medication; D013345:Subarachnoid Hemorrhage / Q000601:surgery*
chemical_list: D000316:Adrenergic alpha-Agonists; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D003975:Diazepam; D010423:Pentazocine