Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behçet's disease in the Turkish population.
Endothelial nitric oxide synthase (eNOS) could be a candidate gene for Behçet's disease (BD). This study investigated the relationship of the eNOS Glu298 --> Asp polymorphism with the presence and severity of BD in the Turkish population. Ninety-two patients with BD and 100 controls were studied. Analyses of Glu298Asp polymorphism in exon 7 of the eNOS gene were made by the polymerase chain reaction (PCR)-restriction fragment length polymorphism technique. The frequencies of the eNOS genotypes were similar for BD patients (GG:GT:TT = 58.7%:38%:3.3%) and controls (59.2%:33.7%:7.1 %), P = 0.335. No evidence of difference was found in the frequency of the T allele between BD patients (22.3%) and controls (24%), [OR = 0.91, 95% CI (0.55-1.50), P = 0.690]. Glu298 --> Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.
Kara
Nurten
N
Department of Medical Biology and Genetics, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, 55139, Samsun, Turkey. nurtenk@omu.edu.tr
Senturk
Nilgun
N
Gunes
Sezgin Ozgur
SO
Bagci
Hasan
H
Yigit
Serbulent
S
Turanli
Ahmet Yasar
AY
D000328:Adult; D001528:Behcet Syndrome / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D004247:DNA / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D012720:Severity of Illness Index; D014421:Turkey / Q000453:epidemiology / Q000208:ethnology
D004247:DNA; D052250:Nitric Oxide Synthase Type III