From ergot to ansamycins-45 years in biosynthesis.
In this review the author traces his scientific career from its beginnings in Germany to his moves to, successively, Purdue University, The Ohio State University, and finally University of Washington. During this time his research progressed from extensive studies on ergot alkaloids, the stereochemistry of enzyme reactions, and tracer studies on antibiotic biosynthesis to its latest emphasis on the molecular biology of ansamycin antibiotics. The formative influence of several mentors and colleagues is acknowledged.
Floss
Heinz G
HG
Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195-1700, USA. floss@chem.washington.edu
D001688:Biological Products / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D004876:Ergot Alkaloids / Q000096:biosynthesis / Q000737:chemistry; D015394:Molecular Structure; D017828:Rifabutin / Q000737:chemistry / Q000378:metabolism
D001688:Biological Products; D004876:Ergot Alkaloids; D017828:Rifabutin