A pregnant woman with anti-Gregory antigen: case report.
Negative Gregory antigen (Gy(a-)) remains an extremely uncommon blood phenotype. We describe a 32-year-old pregnant woman with (Gy(a-)) and anti-Gregory antigen (anti-Gy(a)). There was no evidence of consanguineous mating in her family. Blood typing study revealed that only her father was Gy(a-) among the family. Anti-Gy(a) had a titer of 16 before pregnancy, but increased to 1024 at 33 weeks of gestation with a titer of 512 at 34 weeks. Her own blood stores were collected starting at 14 weeks, amounting to 1800 g totally. She underwent an emergency cesarean section at 35 weeks due to a non-reassuring fetal status. Blood loss was approximately 1090 g. Cord blood type was found to be Gy(a-). The indirect Coombs test of cord blood was positive, while the direct Coombs test was negative. No neonatal hemorrhagic disease developed. The storage of a sufficient amount of crossmatch-compatible Gy(a-) blood during pregnancy is important in case of possible need of blood transfusion at delivery for women with anti-Gy(a).
Takamatsu
Y
Y
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Morita
H
H
Ohara
N
N
Makihara
N
N
Funakoshi
T
T
Moriyama
T
T
Maruo
T
T
D000328:Adult; D001789:Blood Group Antigens / Q000276:immunology*; D001788:Blood Grouping and Crossmatching; D003298:Coombs Test; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D011247:Pregnancy / Q000097:blood*; D011256:Pregnancy Outcome
D001789:Blood Group Antigens; D007518:Isoantibodies