The human stomach after antrectomy. A study of the type of epithelium, occurrence of gastrin-producing cells, and basal serum gastrin.
A histological and immunohistological investigation was performed on biopsy specimens from ten patients 3 to 35 years after antrectomy, to study the type of epithelium and the possible occurrence of gastrin-producing cells (G cells) in the distal stump of the stomach remnant. The study showed that parietal cells were present in all patients, whereas G cells could not be demonstrated, although areas of pyloric-type epithelium (pseudopyloric metaplasia, were seen in eight. We conclude that the pyloric-type metaplasia, which occurs in the fundic mucosa after antrectomy, does not involve the G cells. It is suggested that the normal levels of fasting serum gastrin in these patients originate from outside the gastric mucosa, presumably from the duodenal bulb.
Nielsen
H O
HO
Institute of Pathology and Dept. of Medical, Odense University Hospital, Denmark.
Lauritsen
K
K
Christiansen
L A
LA
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D004848:Epithelium / Q000473:pathology; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology; D005500:Follow-Up Studies; D005743:Gastrectomy; D005744:Gastric Acid / Q000378:metabolism; D019863:Gastrin-Secreting Cells / Q000378:metabolism / Q000473:pathology*; D005755:Gastrins / Q000097:blood*; D005757:Gastritis, Atrophic / Q000473:pathology / Q000601:surgery; D005773:Gastroscopy; D006801:Humans; D011184:Postoperative Period; D011706:Pyloric Antrum / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D011863:Radioimmunoassay; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery; D013276:Stomach Ulcer / Q000473:pathology / Q000601:surgery; D013997:Time Factors
D005755:Gastrins