title: Relation between severity of injury and the early activation of interleukins in multiple-injured patients.
abstract: The aim of this study was to evaluate the relation between severity of injury and the early activation of interleukins in multiple-injured patients. Ninety-nine patients with multiple injuries were included in this prospective study. Plasma levels of interleukin (IL)-1, IL-2, IL-6, IL-8 and TNF-alpha were measured. Injury Severity Score (ISS), Revised Trauma Score (RTS), Glasgow Coma Score (GCS) and the Acute Physiology and Chronic Health Evaluation II (APACHE-II) were all recorded. Of the 99 patients, 82 were male and 17 were female. The mean age was 26.6+/-20.7 years. The mortality rate for this series was 17%. Patients who died from trauma exhibited a significant increase for IL-2, IL-6 and IL-8 in comparison with patients who survived. Significant differences for ISS, RTS and GCS were found between survivors and non-survivors. Values in all patients with ISS>16 were increased and these increases were significant for IL-6 and IL-2. These data show that the initial increase of IL-2, IL-6 and IL-8 might predict the patients with a high possibility of mortality and a significant increase of IL-2 and IL-6 in patients with ISS>16 might be used in a new developed trauma score combined with ISS as an indicator for the injury severity.
authors.affiliation: Department of General Surgery, Dicle University Medical School, Diyarbakir, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Yagmur
authors.forename: H
authors.initials: H
authors.lastname: Ozturk
authors.forename: M
authors.initials: M
authors.lastname: Unaldi
authors.forename: E
authors.initials: E
authors.lastname: Gedik
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D015601:Injury Severity Score; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D015599:Trauma Severity Indices; D014421:Turkey / Q000453:epidemiology; D014947:Wounds and Injuries / Q000276:immunology* / Q000401:mortality
chemical_list: D007378:Interleukins