Human leukocyte antigen polymorphisms: variable humoral immune responses to viral vaccines.
Antibody formation in response to antigen stimulation remains the basis for measuring an individual's response and protection for most viral vaccines. A significant proportion of the variation in individual humoral immune response to vaccination appears to be genetic. The collection of genes found on chromosome 6 forming the human leukocyte antigen system provides one of the greatest sources of genetic variation in individuals with respect to their immunological responses. Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles. These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines.
Ovsyannikova
Inna G
IG
Department of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA. ovsyannikova.inna@mayo.edu
Dhiman
Neelam
N
Jacobson
Robert M
RM
Poland
Gregory A
GA
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000940:Antigenic Variation / Q000235:genetics* / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D011110:Polymorphism, Genetic; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D006680:HLA Antigens; D014765:Viral Vaccines