title: Use of a B-type natriuretic peptide in evaluating the treatment response of a relapsed lymphoma with cardiac involvement.
abstract: A 50-year-old woman received a diagnosis of diffuse large B-cell non-Hodgkin's lymphoma in 2000 and achieved complete remission. In April 2004, echocardiography and computed tomography examinations identified a tumor attached to the tricuspid valve and protruding within the right atrium. Bone marrow and lymph node biopsies showed a relapse of large cell lymphoma. The patient had a markedly elevated level of B-type natriuretic peptide (BNP) but a normal level of cardiac troponin I. The follow-up evaluation of the BNP level after chemotherapy showed that it had returned to within normal limits, and an echocardiogram showed regression of the tumor. Use of the BNP level as a monitor in the treatment of cardiac lymphoma has never been reported. This article is the first to report the use of BNP monitoring before and after chemotherapy to evaluate a patient with an unusual relapsed lymphoma with cardiac involvement.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Pao-Hsien
authors.initials: PH
authors.lastname: Chu
authors.forename: Ming-Chung
authors.initials: MC
authors.lastname: Kuo
authors.forename: Shih-Ming
authors.initials: SM
authors.lastname: Jung
authors.forename: Kun-Eng
authors.initials: KE
authors.lastname: Lim
authors.forename: Chi-Tai
authors.initials: CT
authors.lastname: Kuo
authors.forename: Lee-Yung
authors.initials: LY
authors.lastname: Shih
mesh_terms: D005260:Female; D006338:Heart Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D006349:Heart Valve Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D016393:Lymphoma, B-Cell / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011859:Radiography; D012008:Recurrence; D014261:Tricuspid Valve / Q000000981:diagnostic imaging
chemical_list: D020097:Natriuretic Peptide, Brain