Association of estrogen receptor-alpha genepolymorphisms with venous thrombosis.
XbaI and PvuII polymorphisms of the estrogen receptor-alpha gene (ERalpha) have been associated with several multifactorial diseases. We studied the distribution of ERalpha polymorphisms in patients with deep vein thrombosis. PvuII PP and XbaI XX genotypes may be associated with an approximately 2-fold increased DVT risk of deep vein thrombosis in men.
Lussana
Federico
F
Faioni
Elena M
EM
Mavilia
Carmelo
C
Bucciarelli
Paolo
P
Brandi
Maria Luisa
ML
Cattaneo
Marco
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015252:Deoxyribonucleases, Type II Site-Specific; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D020246:Venous Thrombosis / Q000235:genetics*
D047628:Estrogen Receptor alpha; C025580:endodeoxyribonuclease XBAI; C025630:CAGCTG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific