T cells and T-cell receptors in acute renal failure.
T cells are activated by antigen-independent as well as antigen-dependent mechanisms during ischemia-reperfusion injury to the kidney. In the current issue, a study by Savransky et al. suggests that antigen-dependent activation of T-cell receptors further contributes to the pathogenesis of ischemia-reperfusion injury.
Portilla
Didier
D
Department of medicine, University fo Arkansas for Medical Sciences, Little Rock, AR 722015, USA. portilladidier@uams.edu
Okusa
Mark D
MD
D058186:Acute Kidney Injury / Q000209:etiology*; D000818:Animals; D018122:B7-1 Antigen / Q000502:physiology; D018106:CD28 Antigens / Q000502:physiology; D007113:Immunity, Innate; D007668:Kidney / Q000098:blood supply*; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015427:Reperfusion Injury / Q000209:etiology*; D013601:T-Lymphocytes / Q000502:physiology*
D018122:B7-1 Antigen; D018106:CD28 Antigens; D011948:Receptors, Antigen, T-Cell