title: Pure sclerotic neurofibroma: a neurofibroma mimicking sclerotic fibroma.
abstract: BACKGROUND
  Neurofibroma (NF) is a benign tumor of the nerve sheath. Several variants of NF have been described.
  
  
  OBJECTIVE
  We report a case of NF with sclerotic changes resembling sclerotic fibroma (SF).
  
  
  RESULTS
  The patient was a 61-year-old man who had an asymptomatic cutaneous lesion on the right scapular region. Physical examination revealed a pedunculated, white-to-pinkish nodule that had a firm consistency, spherical morphology, and smooth surface. Microscopically, the nodule showed a well-circumscribed, nonencapsulated dermal tumor composed of scant cells and thick collagen bundles with prominent clefts. The tumor cells were immunoreactive for vimentin and S100 protein. The patient was diagnosed as having pure sclerotic NF. To our knowledge, only five cases of NF with SF-like pattern have been previously published, and in two this pattern was pure.
  
  
  CONCLUSIONS
  It is important to recognize this exceptional type of NF because it may be easily confused with SF, as well as with a wide variety of neoplasms or hamartomatous conditions containing similar sclerotic pattern.
authors.affiliation: Department of Anatomical Pathology, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: González-Vela
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Val-Bernal
authors.forename: Marcos A
authors.initials: MA
authors.lastname: González-López
authors.forename: Marta
authors.initials: M
authors.lastname: Drake
authors.forename: J Héctor
authors.initials: JH
authors.lastname: Fernández-Llaca
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005350:Fibroma / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009455:Neurofibroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D012598:Sclerosis; D012878:Skin Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins; D014746:Vimentin