Vitronectin in atherosclerotic disease.
Atherosclerosis is characterized by the development of an intimal thickening that contains monocytes, T lymphocytes, and smooth muscle cells within an accumulation of lipid and extracellular matrix proteins. Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Because of its ability to bind platelet glycoproteins and mediate platelet adhesion and aggregation at sites of vascular injury, vitronectin has become an important mediator in the pathogenesis of coronary atherosclerosis.
Ekmekçi
Ozlem Balci
OB
Istanbul University, Istanbul Medical Faculty, Department of Pediatric Heamatology/Oncology, Bone Marrow Transplantation Unit, Istanbul, Turkey.
Ekmekçi
Hakan
H
D000818:Animals; D050197:Atherosclerosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002448:Cell Adhesion; D002465:Cell Movement; D006487:Hemostasis; D006801:Humans; D013927:Thrombosis / Q000378:metabolism / Q000473:pathology; D019096:Vitronectin / Q000276:immunology / Q000378:metabolism*
D019096:Vitronectin