Inflammation in renal disease.
Inflammation is a component of the major modifiable risk factors in renal disease. Elevated high-sensitivity C-reactive protein (hs-CRP) levels have been shown to predict all-cause and cardiovascular mortality in patients dependent on dialysis and to predict worsening renal function in subjects without overt renal disease. Levels of hs-CRP are also predictive of hypertension, a major risk factor for renal disease, across all levels of blood pressure in subjects without initial hypertension. Many of the treatments used in patients with renal disease exert anti-inflammatory activities that constitute or contribute to their therapeutic effects. A number of studies have indicated that statin therapy exerts a renoprotective effect that is possibly mediated by anti-inflammatory activities.
Vidt
Donald G
DG
Department of Nephrology and Hypertension, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. vidtd@ccf.org
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D014943:Global Health; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000097:blood; D007674:Kidney Diseases / Q000097:blood / Q000150:complications*; D012307:Risk Factors; D015996:Survival Rate
D015415:Biomarkers; D002097:C-Reactive Protein