Multiple pituitary hormone deficiency (MPHD) associated with normal height, absent puberty and obesity.
We present a 22-year old girl with MPHD and a normal pituitary imaging (MRI) who grew to normal size without GH. She was very obese. At age 19 years replacement therapy with hydrocortisone, L-thyroxine and sex steroids was started. Despite severe growth hormone deficiency according to the provocative tests and decreased IGF I level our patient grew normally. On follow up at age 22 she is 174cm tall.
Doknic
Mirjana
M
Neuroendocrine Unit, Institute of Endocrinology University Clinical Center, Belgrade, Serbia and Montenegro.
Pekic
Sandra
S
Djurovic
Marina
M
Zivkovic
Vladimir
V
Popovic
Vera
V
D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000150:complications* / Q000151:congenital; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000150:complications*; D010907:Pituitary Hormones / Q000097:blood* / Q000172:deficiency; D011628:Puberty, Delayed / Q000097:blood / Q000150:complications*
D010907:Pituitary Hormones; D007334:Insulin-Like Growth Factor I