Memory reactivation, dissociated from behavioural expression, decreases ERK phosphorylation in the rat prefrontal cortex and amygdala.
The involvement of MAPK pathways in retrieval was investigated in a situation where reactivation of memory was dissociated from its behavioural expression. In rats trained in a brightness avoidance discrimination task, exposure to the discriminative stimulus had behavioural and molecular consequences: a facilitation of the retention performance and a decrease in ERK phosphorylation in the prefrontal cortex and amygdala, but not in the hippocampus. These results indicate that reactivation processes engage a down-regulation of ERK, possibly related to increases in glucocorticoids, in the amygdala and prefrontal cortex already known to be involved in emotional retrieval.
Botreau
Fanny
F
Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication, CNRS UMR 8620, Université Paris Sud, 91405 Orsay Cedex, France.
Gisquet-Verrier
Pascale
P
D000679:Amygdala / Q000201:enzymology*; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D015536:Down-Regulation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D011939:Mental Recall / Q000502:physiology*; D010766:Phosphorylation; D017397:Prefrontal Cortex / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012153:Retention, Psychology / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D048049:Extracellular Signal-Regulated MAP Kinases