title: Expression of aquaporin-9 immunoreactivity by catecholaminergic amacrine cells in the rat retina.
abstract: Aquaporins are involved in the maintenance of ionic and osmotic balance in the central nervous system and in the eye. Whereas the expression of aquaporin-9 immunoreactivity in the brain has been described for catecholaminergic neurons and glial cells, the expression of aquaporin-9 in the neural retina is unclear. We examined the distribution of aquaporin-1 and -9 immunoreactivities in retinas of the rat. Aquaporin-9 immunoreactivity was expressed exclusively by tyrosine hydroxylase (TH) positive amacrine cells, while aquaporin-1 immunoreactivity was expressed by photoreceptor cells and by TH negative amacrine cells. The staining pattern of aquaporin-9 did not change up to 4 weeks after pressure-induced transient retinal ischemia. It is concluded that catecholaminergic, putatively dopaminergic, amacrine cells of the retina express aquaporin-9.
authors.affiliation: Paul Flechsig Institute of Brain Research, University of Leipzig Medical Faculty, Jahnallee 59, 04109 Leipzig, Germany.
authors.forename: Ianors
authors.initials: I
authors.lastname: Iandiev
authors.forename: Bernd
authors.initials: B
authors.lastname: Biedermann
authors.forename: Andreas
authors.initials: A
authors.lastname: Reichenbach
authors.forename: Peter
authors.initials: P
authors.lastname: Wiedemann
authors.forename: Andreas
authors.initials: A
authors.lastname: Bringmann
mesh_terms: D025042:Amacrine Cells / Q000378:metabolism*; D000818:Animals; D051398:Aquaporin 1 / Q000096:biosynthesis; D020346:Aquaporins / Q000096:biosynthesis*; D002395:Catecholamines / Q000378:metabolism*; D007150:Immunohistochemistry; D007511:Ischemia / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D012160:Retina / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: C496022:Aqp1 protein, rat; C491637:Aqp9 protein, rat; D020346:Aquaporins; D002395:Catecholamines; D051398:Aquaporin 1; D014446:Tyrosine 3-Monooxygenase