title: Hippocampal volume is associated with physician-reported acute cognitive deficits after electroconvulsive therapy.
abstract: Predicting memory problems in older depressed patients receiving electroconvulsive therapy (ECT) is difficult. In this study, hippocampal volume and acute memory outcomes were examined in 15 patients following an index course of ECT. Smaller hippocampal volume was associated with poorer ECT-related memory outcomes. These results add to a growing literature on memory, ECT, and the hippocampus. Although the findings are significant, the sample size in the study is small, so future studies with more complex modeling of key variables that may influence memory are warranted.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Ruby
authors.initials: R
authors.lastname: Lekwauwa
authors.forename: Douglas
authors.initials: D
authors.lastname: McQuoid
authors.forename: David C
authors.initials: DC
authors.lastname: Steffens
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D004292:Dominance, Cerebral / Q000502:physiology; D004565:Electroconvulsive Therapy; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008432:Mathematical Computing; D008569:Memory Disorders / Q000175:diagnosis* / Q000523:psychology; D011939:Mental Recall / Q000502:physiology; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D010552:Personality Assessment; D011379:Prognosis; D012307:Risk Factors; D013223:Statistics as Topic