title: Effects of two Prunella species on lymphocyte proliferation and nitric oxide production.
abstract: Water extracts of Prunella vulgaris and P. laciniata have been investigated for their immunomodulatory and antiinflammatory activities concerning their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro. It was found that both extracts stimulated the proliferation of T-lymphocytes and suppressed NO production in lipopolysaccharide-stimulated macrophages dose dependently without any cytotoxicity.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Sihhiye, Ankara, Turkey. sharput@hacettepe.edu.tr
authors.forename: U Sebnem
authors.initials: US
authors.lastname: Harput
authors.forename: Iclal
authors.initials: I
authors.lastname: Saracoglu
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ogihara
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000378:metabolism*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D031347:Prunella; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D010936:Plant Extracts; D009569:Nitric Oxide