Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury.
Interactions of cells with their microenvironment modify the cellular sensitivity of normal and tumor cells for radiation- and drug-induced genotoxic injury. The preexistent or acquired cellular resistance against such agents aggravates anticancer therapies and, therefore, complicates the recovery of patients. Recently, integrin-mediated adhesion was shown to improve cell survival of both normal and cancer cells following DNA damage. Here, I will discuss the role of integrins and integrin-mediated signaling cascades in the survival or death response upon genotoxic stress. Detailed knowledge of the responsible molecular processes might provide implications for putative therapies targeting integrins or integrin-associated molecules to achieve an optimization of anticancer treatments.
Cordes
Nils
N
OncoRay-Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden,Fetscherstrasse 74/PF 86, 01307 Dresden, Germany. nils.cordes@oncoray.de
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D004249:DNA Damage; D005109:Extracellular Matrix / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016023:Integrins / Q000096:biosynthesis / Q000378:metabolism*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000139:chemically induced* / Q000628:therapy*; D015398:Signal Transduction
D000970:Antineoplastic Agents; D016023:Integrins