The frequency of chromosomal abnormalities in patients with reproductive failure.
OBJECTIVE
To investigate the ratio of chromosomal abnormalities in recurrent fetal wastage.


METHODS
We conducted a study of the cytogenetic data of 645 couples (1290 patients) with recurrent fetal wastage examined at the Department of Medical Biology and Genetics, Trabzon, Turkey. Couples who had first trimester miscarriages/abortion, preceded or followed by a second or third trimester fetal death/fetal abnormalities were recruited from Obstetrics and Gynecology Clinics for cytogenetics analysis.


RESULTS
Chromosome abnormalities were found in 25 (3.86%) patients. The chromosomal abnormalities were structural (3.71%) and numerical (0.15%). Polymorphisms of heterochromatin blocks and inv(9) were shown in 115 (17.51%) patients.


CONCLUSIONS
Chromosome analyses are an important and necessary part of the etiological research in couples with recurrent fetal wastage.
Celep
Figen
F
Karadeniz Technical University, Faculty of Medicine, Department of Medical Biology and Genetics, Trabzon, Turkey. gencelep@yahoo.com
Karagüzel
Ahmet
A
Ozeren
Mehmet
M
Bozkaya
Hasan
H
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D003582:Cytogenetics; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014178:Translocation, Genetic; D014421:Turkey / Q000453:epidemiology