NnrA is required for full virulence and regulates several Brucella melitensis denitrification genes.
We identified two regulators of denitrification genes in Brucella melitensis 16M: NarR, which regulates the nitrate reductase (nar) operon, and NnrA, which is involved in the expression of the last three reductases of the denitrification pathway (nirK, norB, and nosZ). NnrA is required for virulence in mice and for intracellular resistance to nitric oxide.
Haine
Valérie
V
Unité de Recherche en Biologie Moléculaire (URBM), University of Namur (FUNDP), 61 rue de Bruxelles, B-5000 Namur, Belgium.
Dozot
Marie
M
Dornand
Jacques
J
Letesson
Jean-Jacques
JJ
De Bolle
Xavier
X
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D017347:Brucella melitensis / Q000235:genetics* / Q000472:pathogenicity; D002006:Brucellosis / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D051379:Mice; D050901:Nitrate Reductase / Q000235:genetics*; D009569:Nitric Oxide; D009876:Operon; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D009569:Nitric Oxide; D050901:Nitrate Reductase