In vitro evaluation of no carrier added, carrier added and cross-complexed [90Y]-EDTMP provides evidence for a novel "foreign carrier theory".
The present study focused on the preparation of novel bone tracers containing yttrium as radionuclide or carrier. Moreover, these preparations were comparatively evaluated in vitro on the basis of a recently presented pre vivo model comprising binding studies on synthetic and human bone powder. It was shown that among the therapeutic radionuclides, no carrier added [(90)Y]-EDTMP exceeded [(188)Re]-EDTMP while yielding lower binding values than [(153)Sm]-EDTMP. Furthermore, the authors investigated the influence of "foreign" carriers added to [(90)Y]-EDTMP, [(99m)Tc]-EDTMP and [(111)In]-EDTMP by the method of cross-complexation. The findings reveal a new paradigm: a carrier more foreign to the complexed radionuclide causes a higher binding increase on human bone matrices in vitro than a more "related" carrier.
Toegel
Stefan
S
Department of Nuclear Medicine, Medical University of Vienna, Austria.
Mien
Leonhard-Key
LK
Wadsak
Wolfgang
W
Eidherr
Harald
H
Viernstein
Helmut
H
Kluger
Rainer
R
Ettlinger
Dagmar
D
Kletter
Kurt
K
Dudczak
Robert
R
Mitterhauser
Markus
M
D001842:Bone and Bones / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry*; D019317:Evidence-Based Medicine; D006801:Humans; D066298:In Vitro Techniques; D009942:Organometallic Compounds / Q000737:chemistry* / Q000493:pharmacokinetics*; D063065:Organophosphonates / Q000737:chemistry* / Q000493:pharmacokinetics*; D011485:Protein Binding; D015021:Yttrium Radioisotopes
D004337:Drug Carriers; D009942:Organometallic Compounds; D063065:Organophosphonates; D015021:Yttrium Radioisotopes; C061699:yttrium ethylenediaminetetra(methylenephosphonic acid)