Role of Caco-2 cell monolayers in prediction of intestinal drug absorption.
The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.
Shah
Pranav
P
Department of Pharmacy, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Post Box 51, Kalabhavan, Vadodara 390 001, India.
Jogani
Viral
V
Bagchi
Tamishraha
T
Misra
Ambikanandan
A
D018938:Caco-2 Cells; D020895:Enterocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011237:Predictive Value of Tests
D004364:Pharmaceutical Preparations