title: Partial irradiation of the breast: Old challenges, new solutions.
abstract: Breast-conserving treatment, characteristically consisting of surgical removal of the tumor and post-operative whole breast irradiation, is nowadays considered as the standard therapeutic approach for most women with stage I/II, invasive breast cancer. Recently, a number of institutions started investigating the feasibility and safety of novel approaches in radiotherapy, modulating concomitantly treatment time and irradiation volume. Whilst this strategy is still under investigation, recent clinical studies on accelerated partial breast irradiation with intra-operative radiotherapy or high conformality irradiation strongly suggest that the way patients with early breast cancer are irradiated should be revisited.
authors.affiliation: Department of Radio-Oncology and Breast Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. jacques.bernier@hcuge.ch
authors.forename: J
authors.initials: J
authors.lastname: Bernier
authors.forename: G
authors.initials: G
authors.lastname: Viale
authors.forename: R
authors.initials: R
authors.lastname: Orecchia
authors.forename: B
authors.initials: B
authors.lastname: Ballardini
authors.forename: A
authors.initials: A
authors.lastname: Richetti
authors.forename: L
authors.initials: L
authors.lastname: Bronz
authors.forename: A
authors.initials: A
authors.lastname: Franzetti-Pellanda
authors.forename: M
authors.initials: M
authors.lastname: Intra
authors.forename: U
authors.initials: U
authors.lastname: Veronesi
mesh_terms: D000465:Algorithms; D001918:Brachytherapy / Q000379:methods; D001940:Breast / Q000528:radiation effects; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D018579:Patient Selection; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal; D012371:Robotics; D017211:Treatment Failure