Synthesis, characterization, and DNA binding of new water-soluble cyclopentadienyl ruthenium(II) complexes incorporating phosphines.
The new water-soluble ruthenium(II) chiral complexes [RuCpX(L)(L')](n+) (X = Cl, I. L = PPh3; L' = PTA, mPTA; L = L' = PTA, mPTA) (PTA = 1,3,5-triaza-7-phosphaadamantane; mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane) have been synthesized and characterized by NMR and IR spectroscopy and elemental analysis. The salt mPTA(OSO2CF3) was also prepared and fully characterized by spectroscopic techniques. X-ray crystal structures of [RuClCp(PPh3)(PTA)] (2), [RuCpI(PPh3)(PTA)] (3), and [RuCpI(mPTA)(PPh3)](OSO2CF3) (9) have been determined. The binding properties toward DNA of the new hydrosoluble complexes have been studied using the mobility shift assay. The ruthenium chloride complexes interact with DNA depending on the hydrosoluble phosphine bonded to the metal, while the corresponding compounds with iodide, [RuCpI(PTA)2] (1), [RuCpI(PPh3)(PTA)] (3), [RuCpI(mPTA)2](OSO2CF3)2 (6), and [RuCpI(mPTA)(PPh3)](OSO2CF3) (9), do not bind to DNA.
Romerosa
Antonio
A
Area de Química Inorgánica, Facultad de Ciencias, Universidad de Almería, Almería, Spain. romerosa@ual.es
Campos-Malpartida
Tatiana
T
Lidrissi
Chaker
C
Saoud
Mustapha
M
Serrano-Ruiz
Manuel
M
Peruzzini
Maurizio
M
Garrido-Cárdenas
Jose Antonio
JA
García-Maroto
Federico
F
D001665:Binding Sites; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D012995:Solubility; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
D003517:Cyclopentanes; D008024:Ligands; D009942:Organometallic Compounds; D010720:Phosphines; D014867:Water; D012428:Ruthenium; D004247:DNA