[Activated eosinophils: techniques to characterize them].
The deleterious role thought to be played by eosinophils in many situations is linked to their ability to secrete various inflammatory substances, mainly toxic proteins and lipid mediators, in body tissue. This ability is a particular feature of activated eosinophils, which have undergone numerous metabolic, functional, and phenotypic changes from their resting state. Characterizing the properties of these activated cells is an essential step in improving our understanding of their contributions to local inflammatory response, as both regulatory and effector cells. Improvements in existing methods as well as the development of new technical approaches have facilitated the ex vivo and in vitro study of activated eosinophils and their contribution to various disease states.
Couissinier-Paris
Patricia
P
Unité de virologie tropicale, Institut de médecine tropicale du service de santé des armées (IMTSSA), Parc du Pharo, Marseille. parispatricia@yahoo.fr
D001249:Asthma / Q000175:diagnosis / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid; D047150:Eosinophil Cationic Protein / Q000032:analysis; D047091:Eosinophil Granule Proteins / Q000032:analysis*; D047093:Eosinophil Major Basic Protein / Q000032:analysis; D047209:Eosinophil Peroxidase / Q000032:analysis; D004802:Eosinophilia / Q000175:diagnosis; D004804:Eosinophils / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D008854:Microscopy, Electron; D010641:Phenotype; D011863:Radioimmunoassay
D047091:Eosinophil Granule Proteins; D047209:Eosinophil Peroxidase; D047150:Eosinophil Cationic Protein; D047093:Eosinophil Major Basic Protein