[Expressions of cystic fibrosis transmembrane conductance regulator in epithelial cells of nasal polyps and normal turbinate mucosae].
OBJECTIVE
To investigate the role of cystic fibrosis transmembrane conductance regulator (CFTR) in human nasal polyps.


METHODS
CFTR were studied in 28 cases of nasal polyps and 7 cases of normal turbinate mucosae with immunochemistry staining.


RESULTS
(1) CFTR was detected in the two tissues and localized mainly in epithelial cells and secretory cells. Its staining showed a more prominent feature in nasal polyps than in normal turbinate mucosae. CFTR showed a typical apical distribution in the normal turbinate mucosae whereas, in the nasal polyps, CFTR demonstrated the other pattern of localization comprising cytoplasmic distribution and typical apical location. (2) Both the CFTR staining intensity of apical and cytoplasmic distribution in the epithelial cell layer from nasal polyps were higher than those from turbinates (P < 0.05, P < 0.05 respectively).


CONCLUSIONS
Over expression and dysfunction of the chloride channels CFTR may play a role in the formation of nasal polyps.
Lin
Shuchun
S
Department of Otorhinolaryngology, Union Hospital, Affiliated to Fujian Medical University, Fuzhou, 350001, China. xhent@sina.com
Lin
Guojing
G
Huang
Jianmin
J
Jiang
Zhangzhou
Z
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D009298:Nasal Polyps / Q000378:metabolism*; D055815:Young Adult
D019005:Cystic Fibrosis Transmembrane Conductance Regulator