title: Encapsulation of quinine by beta-cyclodextrin: excellent model for mimicking enzyme-substrate interactions.
abstract: An inclusion complex formed by beta-cyclodextrin and quinine has been investigated in solution and in the solid state, in which the quinoline ring and the aliphatic ring locate in different hydrophobic cavities, respectively. The study on the inclusion geometry and weak interactions shows that the difference in conformation for this complex is a result of three main packing arrangement considerations, which can provide an ideal model mimicking enzyme-substrate interactions.
authors.affiliation: College of Sciences, Tianjin University of Science and Technology, Tianjin 300071, PRC. zhifan@public.tpt.tj.cn
authors.forename: Zhi
authors.initials: Z
authors.lastname: Fan
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Diao
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Song
authors.forename: Zuo-Liang
authors.initials: ZL
authors.lastname: Jing
authors.forename: Ming
authors.initials: M
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Min-Jie
authors.initials: MJ
authors.lastname: Guo
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D011803:Quinine / Q000737:chemistry* / Q000378:metabolism*; D013379:Substrate Specificity; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; D011803:Quinine