title: [Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient].
abstract: A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.
authors.affiliation: 14th Department of Internal Medicine, Sapporo Medical University, School of Medicine.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Akihito
authors.initials: A
authors.lastname: Fujimi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Kageaki
authors.initials: K
authors.lastname: Kuribayasi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Sumio
authors.initials: S
authors.lastname: Sakamaki
authors.forename: Kyuhei
authors.initials: K
authors.lastname: Kohda
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000257:Adenoviridae Infections; D000284:Administration, Oral; D000741:Anemia, Aplastic / Q000628:therapy; D000998:Antiviral Agents / Q000008:administration & dosage*; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D051359:Lymphohistiocytosis, Hemophagocytic / Q000188:drug therapy* / Q000821:virology*; D008875:Middle Aged; D009894:Opportunistic Infections; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012254:Ribavirin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D012254:Ribavirin