title: Molecular genetics of non-syndromic deafness.
abstract: One in every 1,000 newborn suffers from congenital hearing impairment. More than 60% of the congenital cases are caused by genetic factors. In most cases, hearing loss is a multifactorial disorder caused by both genetic and environmental factors. Molecular genetics of deafness has experienced remarkable progress in the last decade. Genes responsible for hereditary hearing impairment are being mapped and cloned progressively. This review focuses on non-syndromic hearing loss, since the gene involved in this type of hearing loss have only recently begun to be identified.
authors.affiliation: Department of Anatomy, Medical School, FAMERP, São José do Rio Preto, SP. vabp@bol.com.br
authors.forename: Vânia B
authors.initials: VB
authors.lastname: Piatto
authors.forename: Ellen C T
authors.initials: EC
authors.lastname: Nascimento
authors.forename: Fabiana
authors.initials: F
authors.lastname: Alexandrino
authors.forename: Camila A
authors.initials: CA
authors.lastname: Oliveira
authors.forename: Ana Cláudia P
authors.initials: AC
authors.lastname: Lopes
authors.forename: Edi Lúcia
authors.initials: EL
authors.lastname: Sartorato
authors.forename: José Victor
authors.initials: JV
authors.lastname: Maniglia
mesh_terms: D003638:Deafness / Q000151:congenital / Q000235:genetics*; D006801:Humans; D008967:Molecular Biology; D011506:Proteins / Q000235:genetics; D013577:Syndrome
chemical_list: D011506:Proteins