title: Electrical space-time abnormalities of ventricular depolarization in patients with Brugada syndrome and patients with complete right-bundle branch blocks studied by magnetocardiography.
abstract: BACKGROUND
  Both ventricular depolarization abnormalities (QRS complex) and repolarization ones (ST/T) are still controversial in literature. The objective of this study was to clarify the space-time variations that occur in patients carriers of Brugada syndrome using Magnetocardiography and also compare them with cases of complete right-bundle branch block (CRBBB) and individuals without any dromotropic disorder (control group).
  
  
  RESULTS
  Magnetocardiograms (MCGs) of Brugada syndrome patients (n = 16), CRBBB patients (n = 14), and members of a control group (n = 46) at rest were recorded. The MCGs were used to produce a whole-heart electrical-activation diagram (W-HEAD), which can visualize the spatial time-variant activation in the whole heart. In the W-HEAD pattern, three activations were located in the left ventricle, and CRBBB patients had a wide peak with about 65-ms delay on the right anterior side. While the Brugada syndrome pattern has a posteromedian left-ventricle excitation, that is half the amplitude that occurs in CRBBB patients, the electrical conduction rate to the posterosuperior septum area was low.
  
  
  CONCLUSIONS
  The W-HEAD data made it possible to visualize space-time depolarization abnormalities. These findings suggest that the electrical conduction rate to the posterosuperior septum area in Brugada syndrome cases is low, and this low activation may be a feature of typical Brugada syndrome.
authors.affiliation: Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, Japan. kandori@rd.hitachi.co.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kandori
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyashita
authors.forename: Kuniomi
authors.initials: K
authors.lastname: Ogata
authors.forename: Wataru
authors.initials: W
authors.lastname: Shimizu
authors.forename: Miki
authors.initials: M
authors.lastname: Yokokawa
authors.forename: Shiro
authors.initials: S
authors.lastname: Kamakura
authors.forename: Kunio
authors.initials: K
authors.lastname: Miyatake
authors.forename: Keiji
authors.initials: K
authors.lastname: Tsukada
authors.forename: Satsuki
authors.initials: S
authors.lastname: Yamada
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Watanabe
authors.forename: Iwao
authors.initials: I
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D002037:Bundle-Branch Block / Q000175:diagnosis / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D013577:Syndrome