title: Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice.
abstract: BACKGROUND
  Uteroglobin-related protein (UGRP) 1, which is highly expressed in the epithelial cells of the airways, has been suggested to play a role in lung inflammation.
  
  
  OBJECTIVE
  The aim of study was to understand the effect of overexpressed UGRP1 on lung inflammation in a mouse model of allergic airway inflammation.
  
  
  METHODS
  Ovalbumin-sensitized and -challenged mice, a model for allergic airway inflammation, were used in conjunction with recombinant adenovirus expressing UGRP1.
  
  
  RESULTS
  We demonstrated that intranasal administration of adeno-UGRP1 successfully delivered UGRP1 to the epithelial cells of airways and markedly reduced the number of infiltrating inflammatory cells, particularly eosinophils, in lung tissue as well as the level of proinflammatory cytokines such as interleukin (IL)-4, IL-5, and IL-13 in bronchoalveolar lavage fluids. The healed phase of inflammation was clearly seen in the peripheral areas of adeno-UGRP1-treated mouse lungs.
  
  
  CONCLUSIONS
  These results demonstrate that UGRP1 can suppress inflammation in the mouse model of allergic airway inflammation. Based on this result, we propose UGRP1 as a novel therapeutic candidate for treating lung inflammation such as is found in asthma.
authors.affiliation: Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Chiba
authors.forename: Reiko
authors.initials: R
authors.lastname: Kurotani
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusakabe
authors.forename: Tomiko
authors.initials: T
authors.lastname: Miura
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Link
authors.forename: Miwa
authors.initials: M
authors.lastname: Misawa
authors.forename: Shioko
authors.initials: S
authors.lastname: Kimura
mesh_terms: D000256:Adenoviridae; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D005260:Female; D005822:Genetic Vectors; D007378:Interleukins / Q000378:metabolism; D008173:Lung Diseases, Obstructive / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012130:Respiratory Hypersensitivity / Q000378:metabolism* / Q000473:pathology; D020545:Respiratory Mucosa / Q000378:metabolism* / Q000473:pathology; D060765:Secretoglobins
chemical_list: D007378:Interleukins; D011506:Proteins; D012333:RNA, Messenger; C449818:Scgb3a2 protein, mouse; D060765:Secretoglobins