Biological exposure indicators: quantification of biological variability using toxicokinetic modeling.
Compartmental and physiologically based toxicokinetic modeling coupled with Monte Carlo simulation were used to quantify the impact of biological variability (physiological, biochemical, and anatomic parameters) on the values of a series of bio-indicators of metal and organic industrial chemical exposures. A variability extent index and the main parameters affecting biological indicators were identified. Results show a large diversity in interindividual variability for the different categories of biological indicators examined. Measurement of the unchanged substance in blood, alveolar air, or urine is much less variable than the measurement of metabolites, both in blood and urine. In most cases, the alveolar flow and cardiac output were identified as the prime parameters determining biological variability, thus suggesting the importance of workload intensity on absorbed dose for inhaled chemicals.
Truchon
Ginette
G
Institut de recherche Robert-Sauvé en santé et en sécurité du travail, Montréal, Québec, Canada. truchon.ginette@irsst.qc.ca
Tardif
Robert
R
Droz
Pierre-Olivier
PO
Charest-Tardif
Ginette
G
Pierrehumbert
Guillaume
G
D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics*; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D019216:Metals, Heavy / Q000493:pharmacokinetics; D008954:Models, Biological; D009010:Monte Carlo Method; D016273:Occupational Exposure / Q000032:analysis*; D009930:Organic Chemicals / Q000493:pharmacokinetics
D000395:Air Pollutants, Occupational; D019216:Metals, Heavy; D009930:Organic Chemicals