Glioma: what is the role of c-Myc, hsp90 and telomerase?
The continuous advancements in cancer research have contributed to the overwhelming evidence of the presence of telomerase in primary and secondary tumours together with hsp90 and c-Myc. This review will discuss the important role of telomerase together with hsp90 and c-Myc within the initiation and progression of gliomas. Also it will review the differential expression of these genes in the different grades of gliomas and the possibility of new treatments targeting these specific genes.
Shervington
A
A
Department of Biological Sciences, University of Central Lancashire, Preston, UK. aashervington@uclan.ac.uk
Cruickshanks
N
N
Wright
H
H
Atkinson-Dell
R
R
Lea
R
R
Roberts
G
G
Shervington
L
L
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D019098:Telomerase / Q000502:physiology*
D018841:HSP90 Heat-Shock Proteins; D016271:Proto-Oncogene Proteins c-myc; D019098:Telomerase