Brainstem circuits regulating gastric function.
Brainstem parasympathetic circuits that modulate digestive functions of the stomach are comprised of afferent vagal fibers, neurons of the nucleus tractus solitarius (NTS), and the efferent fibers originating in the dorsal motor nucleus of the vagus (DMV). A large body of evidence has shown that neuronal communications between the NTS and the DMV are plastic and are regulated by the presence of a variety of neurotransmitters and circulating hormones as well as the presence, or absence, of afferent input to the NTS. These data suggest that descending central nervous system inputs as well as hormonal and afferent feedback resulting from the digestive process can powerfully regulate vago-vagal reflex sensitivity. This paper first reviews the essential "static" organization and function of vago-vagal gastric control neurocircuitry. We then present data on the opioidergic modulation of NTS connections with the DMV as an example of the "gating" of these reflexes, i.e., how neurotransmitters, hormones, and vagal afferent traffic can make an otherwise static autonomic reflex highly plastic.
Travagli
R Alberto
RA
Department of Neuroscience, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA. travagra@pbrc.edu
Hermann
Gerlinda E
GE
Browning
Kirsteen N
KN
Rogers
Richard C
RC
D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D013270:Stomach / Q000294:innervation* / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology