Involvement of novel PKC isoforms in FFA induced defects in insulin signaling.
Involvement of novel PKCs (nPKCs) in the negative regulation of insulin-signaling pathway is a current interest of many workers investigating the cause for insulin resistance and type 2 diabetes. Free fatty acids (FFAs) are recently shown to be the major players in inducing insulin resistance in insulin target cells. They are also found to be involved in activating nPKCs associated with the impairment of insulin sensitivity. In this overview, we describe PKC delta, theta and epsilon linked to the FFA induced damage of insulin-signaling molecules.
Dey
Debleena
D
Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India.
Basu
Dipanjan
D
Roy
Sib Sankar
SS
Bandyopadhyay
Arun
A
Bhattacharya
Samir
S
D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008954:Models, Biological; D020033:Protein Isoforms / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D011493:Protein Kinase C / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D020033:Protein Isoforms; D011493:Protein Kinase C