[Prepulse inhibition among four strains of mice: effects of type of prepulse and lead time].
The effects of the type of prepulse (PP: visual 30 ms and auditory 30 ms) and lead time (50, 100, 200 ms) on the acoustic startle inhibition (prepulse inhibition: PPI) were tested and compared among four strains of inbred mice (BALB/cA, C3H/HeJ, C57BL/6J, and DBA/2N: all n=11). Following 40 trials of habituation using single pulse (white noise: P; 115 dB, 50 ms), the prepulse session made of 36 trials was conducted. In the habituation, the startle amplitude and peak latency were measured. DBA mice showed weaker startle amplitude than the other 3 strains. The peak latency of the BALB mice was faster than the other strains. The PPI by auditory PP was largest in C57BL, followed by C3H, and the least in BALB mice. DBA mice showed no PPI effect. The PPI under visual prepulse condition was observed only in BALB strain. Contrary, DBA mice showed prepulse facilitation in the 50 ms lead time condition.
Iso
Hiroyuki
H
Department of Behavior Science, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya 663 8501, Japan. iso@hyo-med.ac.jp
D000161:Acoustic Stimulation; D000818:Animals; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011930:Reaction Time; D013216:Reflex, Startle / Q000502:physiology*; D013997:Time Factors