title: Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary alkyl halides with aryl Grignard reagents.
abstract: Simple catalysts formed in situ from iron chloride and a wide range of monodentate and bidentate phosphines and arsines have been screened in the coupling of alkyl halides bearing beta-hydrogens with aryl Grignard reagents. The best of these show excellent activity, as do catalysts formed in situ with monodentate trialkyl and triaryl phosphite ligands. N-heterocyclic carbene-based precatalysts, either preformed or made in situ, also show excellent performance.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K. r.bedford@bristol.ac.uk
authors.forename: Robin B
authors.initials: RB
authors.lastname: Bedford
authors.forename: Michael
authors.initials: M
authors.lastname: Betham
authors.forename: Duncan W
authors.initials: DW
authors.lastname: Bruce
authors.forename: Andreas A
authors.initials: AA
authors.lastname: Danopoulos
authors.forename: Robert M
authors.initials: RM
authors.lastname: Frost
authors.forename: Michael
authors.initials: M
authors.lastname: Hird