The admixture linkage disequilibrium and genetic linkage inference on the gradual admixture population.
Through the theoretical analysis of the admixture linkage disequilibrium (ALD) in the gradual admixture (GA) model, in which admixture occurs in every generation, the ALD is found to be proportional to the difference in marker allele frequencies, P1 - P2, between two subpopulations. Based on this property, we can employ a strict monotonic function (delta(ker) = delta/(P1-P2), where delta denotes the linkage disequilibrium (LD)) of the recombination fraction between the marker locus and the disease locus to infer the true genetic linkage. We construct a quasi likelihood ratio test (LRT) for the case-only data utilizing the information of unlinked markers in the human genome. The simulation results show that our tests can be used to fine map a disease locus. The effects of parameter values in the ALD mapping are also discussed.
Guo
Wei
W
Department of Statistics and Actuarial Science, the University of Hong Kong, Hong Kong, China. guoweidora@hkusua.hku.hk
Fung
Wing-Kam
WK
D001741:Black or African American / Q000208:ethnology / Q000235:genetics; D002681:China; D003198:Computer Simulation; D005787:Gene Frequency; D008040:Genetic Linkage; D005828:Genetics, Population; D006630:Hispanic or Latino / Q000208:ethnology / Q000235:genetics; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium / Q000235:genetics*; D008957:Models, Genetic