title: Evaluation of three different strengths of trichloroacetic acid in xanthelasma palpebrarum.
abstract: BACKGROUND
  Xanthelasma is a common cutaneous condition that presents in the periocular region. Essentially benign, treatment is of cosmetic importance.
  
  
  OBJECTIVE
  Evaluation of varying strengths of trichloroacetic acid (TCA) in xanthelasma palpebrarum.
  
  
  METHODS
  Three strengths of TCA were used on 51 patients randomly after categorizing their xanthelasma into papulo-nodular, flat plaques and macular lesions. The average number of sittings was calculated in each category and patients were reviewed fortnightly.
  
  
  RESULTS
  Papulo-nodular lesions required an average of two applications with 100%, 2.67 with 70% and 4.16 with 50% TCA. Flat plaques responded to an average of 1.43, 1.50 and 3.55 sittings with 100%, 70% and 50% TCA, respectively. Macular lesions responded to only one application of all strengths of TCA applied. Eleven patients developed hypopigmentation, five had hyperpigmentation and one developed mild scarring.
  
  
  CONCLUSIONS
  100% TCA gives the best results in papulo-nodular lesions, 100% or 70% TCA give similar results in flat plaque xanthelasma and in macular lesions 50% is sufficient. Hypopigmentation is the commonest side effect, followed by hyperpigmentation. Scarring is a minor problem.
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Deendayal Upadhyay Hospital, Govt. of NCT of Delhi, Harinagar, New Delhi, India. runamoin@indiatimes.com
authors.forename: Moin-Ul
authors.initials: MU
authors.lastname: Haque
authors.forename: V
authors.initials: V
authors.lastname: Ramesh
mesh_terms: D000328:Adult; D000368:Aged; D002424:Caustics / Q000008:administration & dosage*; D005141:Eyelid Diseases / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014238:Trichloroacetic Acid / Q000008:administration & dosage*; D014973:Xanthomatosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002424:Caustics; D014238:Trichloroacetic Acid