title: Living kidney donors >60 years of age: is it acceptable for the donor and the recipient?
abstract: Donors >60 years are now frequently accepted for living kidney transplantation (LKT). We asked whether a donor age >60 years may result in a higher risk for donor and recipient. All adult LKT from May 1996 to June 2005 were included. Long-term outcome was analysed, and results were compared for donors >60 and <or=60 years. Thirty-five grafts were obtained from donors >60 (group A) and 158 from donors <or=60 years (group B). In group A 40% and in group B 37% of grafts came from unrelated donors (P = 0.769). The mean hospital stay of donors was 8 days in group A and 7 days in group B (P = 0.171). The complication rate was 11% in group A and 17% in group B (P = 0.409). Following LKT primary graft function was observed in 97% in group A and 96% in group B. One- and 5-year graft survival was 97% and 90% in group A and 99% and 91% in group B. For the first 2 years, mean serum creatinine was significantly higher in recipients of group A. Thereafter, values were comparable for both groups. As excellent results are achievable using living donors >60 years, we suggest that age should no longer be considered as a contra-indication for living donation.
authors.affiliation: Klinik fuer Allgemein-, Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany. neipp.michael@mh-hannover.de
authors.forename: Michael
authors.initials: M
authors.lastname: Neipp
authors.forename: Steffan
authors.initials: S
authors.lastname: Jackobs
authors.forename: Mark
authors.initials: M
authors.lastname: Jaeger
authors.forename: Anke
authors.initials: A
authors.lastname: Schwarz
authors.forename: Rainer
authors.initials: R
authors.lastname: Lueck
authors.forename: Wilfried
authors.initials: W
authors.lastname: Gwinner
authors.forename: Thomas
authors.initials: T
authors.lastname: Becker
authors.forename: Juergen
authors.initials: J
authors.lastname: Klempnauer
mesh_terms: D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012306:Risk; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003404:Creatinine