Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.
Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.
Khan
Inshad Ali
IA
Biotechnology Division, Regional Research Laboratory, Jammu Tawi 180001, India. inshad@rrljammu.org
Mirza
Zahid Mehmood
ZM
Kumar
Ashwani
A
Verma
Vijeshwar
V
Qazi
Ghulam Nabi
GN
D000470:Alkaloids / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D052117:Benzodioxoles; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004996:Ethidium / Q000493:pharmacokinetics; D008826:Microbial Sensitivity Tests; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism
D000470:Alkaloids; D000890:Anti-Infective Agents; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D002939:Ciprofloxacin; D004996:Ethidium; C008922:piperine