title: Folinic acid-responsive seizures initially responsive to pyridoxine.
abstract: This report presents a male who developed clonic seizures on the day he was born. The next day, the diagnosis of pyridoxine-dependent seizures was made. However, contradictory to this diagnosis, seizures reappeared despite treatment with pyridoxine. Seizures ceased after folinic acid was initiated. The clinical and biochemical characteristics of folinic acid-responsive seizures are reviewed. Treatment with folinic acid should be considered in neonatal seizures of unknown origin that do not respond to pyridoxine, or manifest a transient response to pyridoxine.
authors.affiliation: Department of Neurology University Hospital Maastricht, Maastricht, The Netherlands. jnic@sneu.azm.nl
authors.forename: Joost
authors.initials: J
authors.lastname: Nicolai
authors.forename: Vivianne H J M
authors.initials: VH
authors.lastname: van Kranen-Mastenbroek
authors.forename: Ron A
authors.initials: RA
authors.lastname: Wevers
authors.forename: Wilfred A P T
authors.initials: WA
authors.lastname: Hurkx
authors.forename: Johan S H
authors.initials: JS
authors.lastname: Vles
mesh_terms: D004827:Epilepsy / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D002955:Leucovorin / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000150:complications; D011736:Pyridoxine / Q000627:therapeutic use*; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D011736:Pyridoxine; D002955:Leucovorin