title: PLA2 inhibitory activity of marine sesterterpenoids cladocorans, their diastereomers and analogues.
abstract: Inhibition of secretory phospholipase A(2) (sPLA(2)) by cladocorans A and B and their diastereomers almost equaled that of manoalide.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan. miyaokah@ps.toyaku.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyaoka
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamanishi
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Mitome
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001514:Bee Venoms / Q000201:enzymology; D001516:Bees; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010726:Phosphodiesterase Inhibitors; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D013237:Stereoisomerism; D013729:Terpenes / Q000494:pharmacology
chemical_list: D001514:Bee Venoms; D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors; D013729:Terpenes; C479318:cladocoran A; C045673:manoalide; D010741:Phospholipases A; D054467:Phospholipases A2; C121906:dysidiolide; D015107:4-Butyrolactone