Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association.
For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads.
Rosenberger
Albert
A
Department of Genetic Epidemiology, Georg-August University Göttingen, Humboldtallee 32, 37073 Göttingen, Germany. arosenb@gwdg.de
Janicke
Nico
N
Köhler
Karola
K
Korb
Katrin
K
Kulle
Bettina
B
Bickeböller
Heike
H
D019973:Alcohol-Related Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D001519:Behavior; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D005071:Evoked Potentials / Q000502:physiology; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D035781:Siblings; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires