Steroidal glycosides from the underground parts of Solanum sodomaeum.
A new steroidal glycoside has been isolated from the underground parts of Solanum sodomaeum L., along with seven known steroidal glycosides. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence, and the structure of one known pregnane type glycoside was corrected. In addition, their antiproliferative activity against human promyelocytic leukemia (HL-60) cells was investigated, and five compounds exhibited stronger activity than cisplatin.
Ono
Masateru
M
School of Agriculture, Kyushu Tokai University, Kumamoto, Japan. mono@kmail.ktokai-u.ac.jp
Nishimura
Kazuya
K
Suzuki
Keita
K
Fukushima
Takeshi
T
Igoshi
Keiji
K
Yoshimitsu
Hitoshi
H
Ikeda
Tsuyoshi
T
Nohara
Toshihiro
T
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D006868:Hydrolysis; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry; D032322:Solanum / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D013256:Steroids; D002945:Cisplatin