title: Salvage of failed massive allograft reconstruction with endoprosthesis.
abstract: A subset of osteoarticular allograft reconstructions after tumor resection ultimately will fail in patients achieving long-term survival. There are several alternative surgical approaches to revising these reconstructions. We retrospectively evaluated the outcome of 20 patients who had allograft reconstruction with a modular endoprosthesis. All patients had a failed massive allograft (average length, 15.7 cm) after tumor resection about the shoulder and knee. The reasons for original allograft failure were fracture (14 patients), infection (five patients), and both (one patient). Followup of the patients averaged 159.7 months (range, 63-293 months) after allograft reconstruction and 77 months (range, 24-234 months) after endoprosthetic revision. The average number of operative procedures each patient had was 4.1 (range, 2-15 procedures). Two patients had amputations for resistant periprosthetic infections. A successful revision procedure was accomplished in 80% of the patients, and 90% of the patients retained functional limbs at recent followup. The predicted 5-, 10-, and 15-year survivals were 92%, 55% and 28% respectively. Musculoskeletal Tumor Society scores averaged 76% (range, 60-93.3%). When used to salvage massive allograft failure from infection and fractures, endoprosthetic revision preserves limb function with minimal complications.
  
  
  METHODS
  Therapeutic study, Level IV (case series). See the Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Department of Orthopedics and Rehabilitation, University of Miami, Miami, FL 33101, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: H Thomas
authors.initials: HT
authors.lastname: Temple
authors.forename: J David
authors.initials: JD
authors.lastname: Pitcher
authors.forename: Varatharaj
authors.initials: V
authors.lastname: Mounasamy
authors.forename: Theodore I
authors.initials: TI
authors.lastname: Malinin
authors.forename: Sean P
authors.initials: SP
authors.lastname: Scully
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D005260:Female; D005269:Femur / Q000601:surgery*; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D006811:Humerus / Q000601:surgery*; D023821:Limb Salvage / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D011475:Prosthesis Failure; D019919:Prosthesis Implantation / Q000295:instrumentation*; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D016896:Treatment Outcome