title: Synthesis of constrained ceramide analogs and their potent antileukemic activities.
abstract: Constrained ceramide analogs were designed and synthesized by binding terminal alcohol and amine of ceramide with additional carbonyl functional group as 3-acetyl (3), 3-propionyl (4), 3-benzoyl (5), and 3-hexadecanoyl-4-(1-hydroxyhexadec-2-enyl)-oxazolidin-2-ones (6). Compounds 4 and 5 showed potent antileukemic activities against human leukemia HL-60 cells with good correlation between cell death and DNA fragmentation.
authors.affiliation: Department of Chemistry, Hankuk University of Foreign Studies, Yongin 449-791, Republic of Korea. hjha@hufs.ac.kr
authors.forename: Hyun-Joon
authors.initials: HJ
authors.lastname: Ha
authors.forename: Myeng Chan
authors.initials: MC
authors.lastname: Hong
authors.forename: Seung Whan
authors.initials: SW
authors.lastname: Ko
authors.forename: Yong Woo
authors.initials: YW
authors.lastname: Kim
authors.forename: Won Koo
authors.initials: WK
authors.lastname: Lee
authors.forename: Jungchan
authors.initials: J
authors.lastname: Park
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002518:Ceramides / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004587:Electrophoresis, Agar Gel; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000473:pathology*
chemical_list: D002518:Ceramides