Ovarian response to stimulation of HIV-positive patients during IVF treatment: a matched, controlled study.
BACKGROUND
Our aim was to compare the ovarian response of HIV-positive and -negative patients during IVF.


METHODS
Setting - HIV and IVF reference university hospital. Twenty-seven HIV-infected patients who had undergone IVF between March 2000 and March 2005 were matched with 77 HIV-negative patients for age, aetiology of infertility, whether it was primary or secondary infertility, duration of infertility, history of pelvic surgery and type of pituitary inhibition. Outcome - poor responders were defined using one of the following criteria: a cancelled cycle (for insufficient ovarian response), less than four mature follicles (> or = 16 mm), peak serum levels of E2 lower than 1000 pg/ml.


RESULTS
There were no differences between the two groups of patients for the matched criteria. The proportion of African women and of women with a history of pelvic inflammatory disease was significantly higher among HIV patients than among the control group. With the exception of a lower number of transferred embryos among HIV-positive patients versus HIV-negative ones (1.3 versus 1.9; P = 0.035), there was no significant difference between the two groups of patients regarding ovarian response parameters.


CONCLUSIONS
HIV-infected patients who are in good general condition and who are matched to a control group present a similar ovarian response to stimulation, suggesting the existence of a similar ovarian reserve.
Martinet
Valérie
V
Department of Obstetrics and Gynaecology, Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Buxelles, Brussels, Belgium.
Manigart
Yannick
Y
Rozenberg
Serge
S
Becker
Benedicte
B
Gerard
Michèle
M
Delvigne
Annick
A
D000328:Adult; D016022:Case-Control Studies; D015232:Dinoprostone / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007247:Infertility, Female / Q000150:complications*; D010062:Ovulation Induction
D015232:Dinoprostone