title: Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.
abstract: 1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps.
authors.affiliation: Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, Republic of Korea. jinho@kmu.ac.kr
authors.forename: Jinho
authors.initials: J
authors.lastname: Lee
authors.forename: Jonghyun
authors.initials: J
authors.lastname: Kim
authors.forename: Jong Sung
authors.initials: JS
authors.lastname: Koh
authors.forename: Hyun-Ho
authors.initials: HH
authors.lastname: Chung
authors.forename: Kyoung-Hee
authors.initials: KH
authors.lastname: Kim
mesh_terms: D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors*; D006827:Hydantoins / Q000494:pharmacology*; D015689:Oncogene Protein p21(ras) / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D006827:Hydantoins; D051231:Farnesyltranstransferase; D015689:Oncogene Protein p21(ras)