title: Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility.
abstract: In 1716 individuals--801 human immunodeficiency virus (HIV)-1-seropositive individuals, 217 high-risk HIV-1-seronegative individuals, and 698 general HIV-1-seronegative individuals--from a Seattle cohort and a Multicenter AIDS Cohort Study cohort, the association between HIV-1 susceptibility and repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule (DC-SIGNR) was investigated; 16 genotypes were found in the DC-SIGNR repeat region. The DC-SIGNR homozygous 7/7 repeat was found to be associated with an increased risk of HIV-1 infection (17.5% in high-risk HIV-1-seronegative individuals vs. 28.5% in HIV-1-seropositive individuals; P=.0015), whereas the DC-SIGNR heterozygous 7/5 repeat tended to be correlated with resistance to HIV-1 infection (35.5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1.
authors.affiliation: Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195-8070, USA.
authors.forename: Huanliang
authors.initials: H
authors.lastname: Liu
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
authors.forename: Chunhui
authors.initials: C
authors.lastname: Wang
authors.forename: Sarah
authors.initials: S
authors.lastname: Holte
authors.forename: Jean
authors.initials: J
authors.lastname: Lee
authors.forename: Benjamin
authors.initials: B
authors.lastname: Greene
authors.forename: Florian
authors.initials: F
authors.lastname: Hladik
authors.forename: David M
authors.initials: DM
authors.lastname: Koelle
authors.forename: Anna
authors.initials: A
authors.lastname: Wald
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kurosawa
authors.forename: Charles R
authors.initials: CR
authors.lastname: Rinaldo
authors.forename: Connie
authors.initials: C
authors.lastname: Celum
authors.forename: Roger
authors.initials: R
authors.lastname: Detels
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: M Juliana
authors.initials: MJ
authors.lastname: McElrath
authors.forename: Tuofu
authors.initials: T
authors.lastname: Zhu
mesh_terms: D015815:Cell Adhesion Molecules / Q000235:genetics*; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*
chemical_list: C433029:CLEC4M protein, human; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface