Sclerodermatous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: incidence, predictors and outcome.
Scleroderma may be one of the most severe forms of chronic graft-versus-host disease (GVHD). We retrospectively evaluated its incidence, predictor variables and outcome in 133 patients who survived at least 4 months after allogeneic hematopoietic stem cell transplantation. The 5-year cumulative incidence was 15.5% in patients with chronic GVHD. The generalized form had a progressive course despite immunosuppressive therapy. Eosinophilia, autoimmune markers, and previous skin involvement by chronic GVHD with disorders of pigmentation were significantly associated with an increased probability of developing scleroderma.
Skert
Cristina
C
Division of Haematology, Dept. of Clinical and Morphological Research, University of Udine. cristina_skert@yahoo.it
Patriarca
Francesca
F
Sperotto
Alessandra
A
Cerno
Michela
M
Filì
Carla
C
Zaja
Francesco
F
Stocchi
Raffaella
R
Geromin
Antonella
A
Damiani
Daniela
D
Fanin
Renato
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000209:etiology*; D014184:Transplantation, Homologous; D016896:Treatment Outcome