[The radiobiologycal approaches of the individual prognosis of the radiotherapy efficacy of the tumor deseases].
The results of several years standing investigations about the develop of the way to the individual prognosis of tumour sensitivity to radiotherapy are brought. The initial level of proliferative activity of different tumour types of individual patients--carcinoma of oropharingeal zone, stomach, oesophagys, rectum, glioblastoma have been studied. It was shown that for the several tumours the high initial level of proliferative activity is the indication of good prognosis. For the all tumours studied the significant decreasing of proliferative activity in the beginning of the radiation treatment is the good prognostic factor of tumour regression (decreasing of volume on 70-100%) or the strong damages of tumour tissue (III-IV grade of patomorphosis). The data of literature of last years are discussed and the proposal is that for the determination of prognostic factors the multiparameter analysis is need.
Pelevina
I I
II
Dar'ialova
S L
SL
Sergeeva
N S
NS
Saenko
A S
AS
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000532:radiotherapy*; D049109:Cell Proliferation / Q000528:radiation effects; D006801:Humans; D051379:Mice; D009367:Neoplasm Staging; D011379:Prognosis; D011836:Radiation Tolerance; D016896:Treatment Outcome
D014408:Biomarkers, Tumor