Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives.
A number of 1- or 6-substituted N9,5'-cyclo-3-(beta-ribofuranosyl)-8-azapurin-2-one derivatives were synthesized in multi-step reactions. Their anti-hepatitis C virus activities were evaluated and some structure-activity relationship is discussed.
Hassan
Abdalla E A
AE
Pharmasset Inc., Tucker, Georgia 30084, USA.
Wang
Peiyuan
P
McBrayer
Tamara
T
Tharnish
Philip
P
Stuyver
Lieven
L
Otto
Michael J
MJ
Watanabe
Kyoichi A
KA
Schinazi
Raymond F
RF
D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011687:Purines; C015008:triazolopyrimidinone; D000241:Adenosine