An updated meta-analysis of genome scans for hypertension and blood pressure in the NHLBI Family Blood Pressure Program (FBPP).
A meta-analysis of the results from a multicenter genome-wide linkage study for hypertension and blood pressure (BP) based on an initial sample of 6,245 individuals was published in 2003. We report here a combined linkage analysis of hypertension and BP using the complete Family Blood Pressure Program (FBPP) dataset, which includes a total of 12,028 genotyped individuals. Genome-wide linkage analyses for hypertension and BP were first performed in each of the studied ethnic group within each network and the results were combined with a meta-analysis using a modified Fisher's method of combining P values. Our meta-analysis of genome scans for the latest FBPP dataset reveals suggestive linkage for hypertension and BP at several regions on the human genome. Strong evidence for linkage at two of these regions, 2p14 and 3p14.1, have also been published in previous meta-analyses, making them good candidate locations for susceptibility variants.
Wu
Xiaodong
X
Department of Preventive Medicine and Epidemiology, Loyola University Chicago Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA. xwu@apache.medctr.luhs.org
Kan
Donghui
D
Province
Michael
M
Quertermous
Tom
T
Rao
D C
DC
Chang
Christy
C
Mosley
Thomas H
TH
Curb
David
D
Boerwinkle
Eric
E
Cooper
Richard S
RS
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D005819:Genetic Markers