title: [The long-term effects of the radiation action and induced genome instability].
abstract: The intensive studies of the long-term effects of the radiation on human and animal cells allowed to reveal the row of new positions in the radiobiology and the genetics. One of the example is the determination of the fact that the genetic effects of the radiation action are not limited by the alterations detectable directly after the corresponding influences. It was found that this and other genome alterations (the chromosome and the gene mutations, transformation the reproductive cell death, the changes of the radiosensitivity and others) can appear de novo in it's sufficiently remote generations of the surviving cells. They differ in the spectrum and in the intensity from acute influence results and now unite with notion "induced genome instability". These discoveries made the studies of the regularities and of the mechanisms of forming of the genome instability in the whole organism of the human and animals more active. In this review about radiation induced instability of genome data are systematized in the accordance with the objects of the study: cultivated cells in vitro-->posterity of laboratory animals-->children born from irradiated parents-->adult people in the remote periods after irradiation.
mesh_terms: D000818:Animals; D016678:Genome / Q000528:radiation effects*; D042822:Genomic Instability; D006801:Humans; D011832:Radiation Injuries; D011839:Radiation, Ionizing; D013995:Time