title: Pyridone derivatives as potent and selective VLA-4 integrin antagonists.
abstract: A novel series of pyridone inhibitors has been identified through pharmacophore analysis, as potent antagonists of VLA-4.
authors.affiliation: Department of Medicinal Chemistry, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK. Jason_Witherington@GSK.com
authors.forename: Jason
authors.initials: J
authors.lastname: Witherington
authors.forename: Vincent
authors.initials: V
authors.lastname: Bordas
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gaiba
authors.forename: Phil M
authors.initials: PM
authors.lastname: Green
authors.forename: Antoinette
authors.initials: A
authors.lastname: Naylor
authors.forename: Nigel
authors.initials: N
authors.lastname: Parr
authors.forename: David G
authors.initials: DG
authors.lastname: Smith
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Takle
authors.forename: Robert W
authors.initials: RW
authors.lastname: Ward
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors*; D011728:Pyridones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D039041:Integrin alpha4beta1; D011728:Pyridones; D019010:Vascular Cell Adhesion Molecule-1