Lysine methylation and 'signaling memory'.
A combination of various post-translational modifications regulates the formation of signaling networks in both the nucleus and the cytosol. Of these, lysine methylation provides a relatively stable marker on histones and contributes to the formation of a distinct pattern of histone-dependent gene regulation ('transcriptional memory'). Thus far, lysine methylation was considered to be nucleus specific; however, recent findings indicate that lysine methylation contributes to receptor-mediated signal transduction in the cytosol.
Su
I-hsin
IH
Laboratory of Lymphocyte Signaling, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. sui@mail.rockefeller.edu
Tarakhovsky
Alexander
A
D000818:Animals; D002467:Cell Nucleus / Q000276:immunology; D003600:Cytosol / Q000276:immunology / Q000502:physiology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008239:Lysine / Q000276:immunology* / Q000502:physiology; D008745:Methylation; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology*
D008239:Lysine