title: A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis.
abstract: This review covers enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) infections, focusing on differences in their virulence factors and regulation. While Shiga-toxin expression from integrated bacteriophages sets EHEC apart from EPEC, EHEC infections often originate from asymptomatic carriage in ruminants whereas human EPEC are considered to be overt pathogens and more host-restricted. In part, these differences reflect variation in adhesin repertoire, type III-secreted effectors and the way in which these factors are regulated.
authors.affiliation: Zoonotic and Animal Pathogens Research Laboratory, Centre for Infectious Diseases, Chancellor's Building, University of Edinburgh, Edinburgh, UK.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Spears
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Roe
authors.forename: David L
authors.initials: DL
authors.lastname: Gally
mesh_terms: D018830:Adhesins, Escherichia coli / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000818:Animals; D002648:Child; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000503:physiopathology; D019453:Escherichia coli O157 / Q000235:genetics / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D012418:Ruminants / Q000382:microbiology; D012703:Serotyping; D022603:Shiga Toxins / Q000096:biosynthesis / Q000235:genetics; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D018830:Adhesins, Escherichia coli; D029968:Escherichia coli Proteins; D022603:Shiga Toxins; D037521:Virulence Factors