title: Effect of percutaneous endoscopic gastrostomy on gastro-esophageal reflux in mechanically-ventilated patients.
abstract: OBJECTIVE
  To investigate the effect of percutaneous endoscopic gastrostomy (PEG) on gastroesophageal reflux (GER) in mechanically-ventilated patients.
  
  
  METHODS
  In a prospective, randomized, controlled study 36 patients with recurrent or persistent ventilator-associated pneumonia (VAP) and GER > 6% were divided into PEG group (n = 16) or non-PEG group (n = 20). Another 11 ventilated patients without reflux (GER < 3%) served as control group. Esophageal pH-metry was performed by the "pull through" method at baseline, 2 and 7 d after PEG. Patients were strictly followed up for semi-recumbent position and control of gastric nutrient residue.
  
  
  RESULTS
  A significant decrease of median (range) reflux was observed in PEG group from 7.8 (6.2 - 15.6) at baseline to 2.7 (0 - 10.4) on d 7 post-gastrostomy (P < 0.01), while the reflux increased from 9 (6.2 - 22) to 10.8 (6.3 - 36.6) (P < 0.01) in non-PEG group. A significant correlation between GER (%) and the stay of nasogastric tube was detected (r = 0.56, P < 0.01).
  
  
  CONCLUSIONS
  Gastrostomy when combined with semi-recumbent position and absence of nutrient gastric residue reduces the gastroesophageal reflux in ventilated patients.
authors.affiliation: Department of Critical Care, Evangelismos Hospital, Athens 10675, Greece. edouzin@cc.uoa.gr
authors.forename: Emmanuel E
authors.initials: EE
authors.lastname: Douzinas
authors.forename: Andreas
authors.initials: A
authors.lastname: Tsapalos
authors.forename: Antonios
authors.initials: A
authors.lastname: Dimitrakopoulos
authors.forename: Evanthia
authors.initials: E
authors.lastname: Diamanti-Kandarakis
authors.forename: Alexandros D
authors.initials: AD
authors.lastname: Rapidis
authors.forename: Charis
authors.initials: C
authors.lastname: Roussos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D005773:Gastroscopy; D005774:Gastrostomy / Q000379:methods*; D006801:Humans; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D011187:Posture; D011446:Prospective Studies; D012121:Respiration, Artificial