title: A new neuroprotective compound of Ligustrum japonicum leaves.
abstract: A new secoiridoid glycoside characterized as (8 Z)-nuezhenide A along with five known glycosides, (8 E)-nuezhenide, (8 Z)-nuezhenide, oleonuezhenide, osmanthuside B and osmanthuside D, were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
authors.affiliation: Elcom Science Co., Ltd., Seoul, Korea.
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Sung
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Kim
authors.forename: Ki Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D031659:Ligustrum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification*; D016627:Oxidopamine; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D018696:Neuroprotective Agents; D016627:Oxidopamine