Sequence variability of human erythroviruses present in bone marrow of Brazilian patients with various parvovirus B19-related hematological symptoms.
The presence of erythrovirus infections was investigated by PCR with bone marrow samples of patients with various parvovirus B19-related hematological symptoms. Erythrovirus DNA was found in 17.3% (12/69) of patients. Phylogenetic analysis revealed that five strains cluster with genotype 1, one clusters with genotype 2, and six cluster with genotype 3. Our study is the first to document the presence of the three erythrovirus genotypes in Brazil.
Sanabani
Sabri
S
Molecular Biology Laboratory, Fundação Pró-Sangue, Hemocentro de São Paulo, Brazil, São Paulo, Brazil. sabinoec@uol.com.br
Neto
Walter Kleine
WK
Pereira
Juliana
J
Sabino
Ester Cerdeira
EC
D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000821:virology*; D001938:Brazil; D002648:Child; D004279:DNA, Viral / Q000032:analysis / Q000302:isolation & purification; D019218:Erythrovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006402:Hematologic Diseases / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000821:virology*; D016732:Parvovirus B19, Human / Q000472:pathogenicity*; D017422:Sequence Analysis, DNA
D004279:DNA, Viral