Bone turnover markers and bone scintigraphy in the evaluation of the skeletal metastases.
BACKGROUND
The aim of this study was evaluation of the clinical usefulness of bone scintigraphy and of serum bone turnover marker levels in the assessment of skeletal metastases.


METHODS
We investigated 60 patients with suspected skeletal metastases. Serum level of bone-formation marker: amino-terminal propeptide of type I procollagen (PINP) and a bone-degradation marker: carboxy-terminal telopeptide of type I collagen (ICTP) were assessed with radioimmunoassays. Bone MDP-99m-Tc scans were performed as well.


RESULTS
Hot spots were showed in 72% of patients. According to bone scintigraphy the patients were divided in to 3 groups: Group I - without hot spots (n=16; 26%), Group II up to 10 hot spots (n=25; 42%) and Group III more that 10 hot spots (n=19; 32%). Mean serum level of ICTP was significantly higher in Group II than in Group I (p< 0.05), as well as in Group III compared to Group II (p< 0.001) and in Group III compared to Group I (p< 0.001). There is only one significant relationship in PINP levels - between Groups II and III.


CONCLUSIONS
The levels of bone pathological degradation (ICTP) and bone formation reflect the metastatic disease extent in bone. Serum ICTP level is more useful in staging metastasis. Significantly higher PINP reflects only a much disseminated process.
Chrapko
Beata E
BE
Chair and Department of Nuclear Medicine, Skubiszewski Medical University of Lublin, Poland.
Nocuń
Anna
A
Gołebiewska
Renata
R
Jankowska
Helena
H
Zaorska-Rajca
Janina
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000556:secondary*; D024042:Collagen Type I; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides; D011347:Procollagen / Q000097:blood*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013669:Technetium Tc 99m Medronate
D014408:Biomarkers, Tumor; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; D019275:Radiopharmaceuticals; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; D013669:Technetium Tc 99m Medronate