title: DeoT, a DeoR-type transcriptional regulator of multiple target genes.
abstract: In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid beta-oxidation and peptide degradation.
authors.affiliation: Department of Molecular Genetics and Biotechnology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Elgrably-Weiss
authors.forename: Eliana
authors.initials: E
authors.lastname: Schlosser-Silverman
authors.forename: Ilan
authors.initials: I
authors.lastname: Rosenshine
authors.forename: Shoshy
authors.initials: S
authors.lastname: Altuvia
mesh_terms: D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; C489070:DeoR protein, E coli; C508890:DeoT protein, E coli; D029968:Escherichia coli Proteins; D012097:Repressor Proteins