title: [Acute or sub-acute thrombosis of steel stents].
abstract: The use of coronary endoprostheses has greatly contributed to the improvement in the results of coronary angioplasty. Nevertheless, the risk of stent thrombosis remains a major preoccupation. We studied a retrospective series of 2997 patients who had undergone coronary angioplasty between 1999 and 2003. 36 patients (1.2%) had an acute or sub-acute stent thrombosis, occurring in two thirds of cases in the first 4 days with particularly serious clinical consequences: 5 deaths (13.8%) and 27 myocardial infarctions (75%). A comparison between the 2 groups of patients with thrombosis (n = 36) and without thrombosis (n = 2961) using multivariate analysis determined predictive factors for thrombosis: systolic LV dysfunction < 40% (p < 0.0001 OR 3.8 [2-7.3]), angioplasty for lesions on the anterior interventricular artery (p < 0.0001 OR 2.7 [1.4-5]), angioplasty performed in the acute phase of MI (p < 0.05 OR 13.9 [6.7-29.2]), B2-type complex lesions (p < 0.01 OR 2.5 [1.3-5]), residual dissection at the dilated site (p < 0.02 OR 5.1 [1.4-18.2]). More than ever, acute thrombosis remains a topical subject. This study emphasises the incidence of steel stent thrombosis; the clinical consequences and the predictive factors for early occlusion.
authors.affiliation: Département des maladies cardiovasculaires du CHU de Nancy, rue du Morvan, 54511 Vandoeuvre-les-Nancy. batricpopovic@wanadoo.fr
authors.forename: B
authors.initials: B
authors.lastname: Popovic
authors.forename: A G
authors.initials: AG
authors.lastname: Casu
authors.forename: M
authors.initials: M
authors.lastname: Angioi
authors.forename: F
authors.initials: F
authors.lastname: Moulin
authors.forename: R
authors.initials: R
authors.lastname: Piquemal
authors.forename: M
authors.initials: M
authors.lastname: Fajraoui
authors.forename: E
authors.initials: E
authors.lastname: Aliot
authors.forename: G
authors.initials: G
authors.lastname: Ethevenot
mesh_terms: D000208:Acute Disease; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods; D003327:Coronary Disease / Q000628:therapy; D003328:Coronary Thrombosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013232:Steel; D015607:Stents / Q000009:adverse effects*
chemical_list: D013232:Steel