[Esophageal atresia and chromosomal abnormalities in a Mexican children population: descriptive analysis].
BACKGROUND
Chromosome alterations are associated with esophageal atresia (EA) in up to 11% of the cases. The morbidity and mortality index of this population is different from other EA patients. The present study was aimed to determine the characteristics of this association in a Mexican infant patient population.


METHODS
Observational, descriptive, retrospective, transversal assay including patients with AE and chromosome alterations over a 31-year period. Gestational age, admittance age, sex, type of atresia, chromosome alteration, additional malformations, treatment, evolution and death cause, were registered.


RESULTS
Seventeen patients (4.61%) out of 368 with EA were included. Chromosome 21 trisomy was detected in 12 children and 5 with 18 trisomy. One to 3 additional malformations were found in 16 patients. Fifteen children were subjected to surgical procedures for EA, and 6 for associated malformations. Fourteen children died in a 140-day follow-up period.


CONCLUSIONS
Coexistence between AE, trisomys and major malformations was characterized by multifactorial complications which determined adverse evolution in the short term.
González-Zamora
J F
JF
Laboratorio de Cirugía Experimental, Instituto Nacional de Pediatría, México.
Villegas-Alvarez
F
F
D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D004933:Esophageal Atresia / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008800:Mexico; D014314:Trisomy