title: Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives.
abstract: A number of 1- or 6-substituted N9,5'-cyclo-3-(beta-ribofuranosyl)-8-azapurin-2-one derivatives were synthesized in multi-step reactions. Their anti-hepatitis C virus activities were evaluated and some structure-activity relationship is discussed.
authors.affiliation: Pharmasset Inc., Tucker, Georgia 30084, USA.
authors.forename: Abdalla E A
authors.initials: AE
authors.lastname: Hassan
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Wang
authors.forename: Tamara
authors.initials: T
authors.lastname: McBrayer
authors.forename: Philip
authors.initials: P
authors.lastname: Tharnish
authors.forename: Lieven
authors.initials: L
authors.lastname: Stuyver
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Otto
authors.forename: Kyoichi A
authors.initials: KA
authors.lastname: Watanabe
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011687:Purines; C015008:triazolopyrimidinone; D000241:Adenosine