title: Supportive periodontal therapy using mechanical instrumentation or 2% minocycline gel: a 12 month randomized, controlled, single masked pilot study.
abstract: OBJECTIVE
  To compare the short-term performance of subgingival local delivery of 2% minocycline gel and conventional subgingival debridement in supportive periodontal therapy (SPT) patients.
  
  
  METHODS
  Forty adult patients having completed active treatment for moderate to advanced chronic periodontitis were included in a randomized, controlled, single masked maintenance care pilot study. Sites with residual pocket probing depths > or =5 mm and bleeding on probing were treated with either minocycline gel (minocycline-group) or scaling and root planing only (debridement-group) at baseline, 3, 6, and 9 months. Clinical and microbiological examinations were performed at baseline, 3, 6, 9, and 12 months.
  
  
  RESULTS
  Full-mouth plaque and bleeding scores remained <10% and <20%, respectively, for both groups throughout the study. In both groups there was a persistent reduction in number of teeth and sites with probing pocket depths > or =5 mm (p<0.05) with no significant differences between the groups. The prevalence of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Prevotella nigrescens, remained at levels < or =10(5) in the majority of patients and sites in both groups.
  
  
  CONCLUSIONS
  This pilot study failed to show a difference between local delivery of 2% minocycline gel as mono-therapy and traditional subgingival debridement in patients on SPT.
authors.affiliation: Department of Periodontology, Eastman Dental Institute, University College London, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: McColl
authors.forename: K
authors.initials: K
authors.lastname: Patel
authors.forename: G
authors.initials: G
authors.lastname: Dahlen
authors.forename: M
authors.initials: M
authors.lastname: Tonetti
authors.forename: F
authors.initials: F
authors.lastname: Graziani
authors.forename: J
authors.initials: J
authors.lastname: Suvan
authors.forename: L
authors.initials: L
authors.lastname: Laurell
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001439:Bacteroides / Q000187:drug effects; D015169:Colony Count, Microbial; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D010865:Pilot Projects; D016966:Porphyromonas gingivalis / Q000187:drug effects; D018713:Prevotella intermedia / Q000187:drug effects; D045242:Prevotella nigrescens / Q000187:drug effects; D016745:Root Planing; D016037:Single-Blind Method; D048373:Treponema denticola / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D008911:Minocycline