title: Nod1-dependent control of tumor growth.
abstract: Nod1, a cytosolic protein that senses meso-diaminopimelic acid-containing ligands derived from peptidoglycan, plays a role in host responses to invasive bacteria. Here we describe a function for Nod1, whereby it controls tumor formation. Cell lines derived from the human breast cancer epithelial cell line MCF-7 were used in a severe combined immune deficiency (SCID) mouse xenograft model to characterize a pathway linking Nod1 to the growth of estrogen-sensitive tumors. In MCF-7 cells, the absence of Nod1 correlates with tumor growth, an increased sensitivity to estrogen-induced cell proliferation, and a failure to undergo Nod1-dependent apoptosis. Conversely, overexpression of Nod1 in MCF-7 cells results in inhibition of estrogen-dependent tumor growth and reduction of estrogen-induced proliferative responses in vitro.
authors.affiliation: Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: da Silva Correia
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Miranda
authors.forename: Nikki
authors.initials: N
authors.lastname: Austin-Brown
authors.forename: Jenny
authors.initials: J
authors.lastname: Hsu
authors.forename: John
authors.initials: J
authors.lastname: Mathison
authors.forename: Rong
authors.initials: R
authors.lastname: Xiang
authors.forename: Huamin
authors.initials: H
authors.lastname: Zhou
authors.forename: Qinxi
authors.initials: Q
authors.lastname: Li
authors.forename: Jiahuai
authors.initials: J
authors.lastname: Han
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ulevitch
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D053474:Nod1 Signaling Adaptor Protein; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C119067:NOD1 protein, human; D053474:Nod1 Signaling Adaptor Protein; D014409:Tumor Necrosis Factor-alpha