Modification of the biophysical characteristics of membranes in commensal Escherichia coli strains from breast cancer patients.
Escherichia coli G35 N49 strain, from the gut of breast cancer patients, in comparison with the E. coli G35 N61 strain, from the gut of healthy people, shows in vitro reduction in growth rates and maximal growth yield. The changes in certain membrane characteristics, such as low membrane potential and disturbance in intramembrane interaction of H+ -ATPase F0F1 with the TrkA system, indicate a dysfunction in ion transport and enzymatic activity. These changes can be detected during fermentation and in anaerobic conditions (in the gut, for example) and may be influenced by unfavorable conditions in the gut of cancer patients.
Mirzoyan
Natella
N
Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia. nmirzoyan@yahoo.com
Pepoyan
Astghik
A
Trchounian
Armen
A
D000332:Aerobiosis; D000693:Anaerobiosis; D001943:Breast Neoplasms / Q000473:pathology*; D002462:Cell Membrane / Q000473:pathology* / Q000502:physiology; D004926:Escherichia coli / Q000254:growth & development / Q000302:isolation & purification / Q000502:physiology*; D005260:Female; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D017136:Ion Transport; D008564:Membrane Potentials / Q000502:physiology*; D011188:Potassium / Q000378:metabolism
D006859:Hydrogen; D017506:H(+)-K(+)-Exchanging ATPase; D011188:Potassium