title: [HIV and the central nervous system].
abstract: Central nervous system complications are common in HIV-1 infected patients and occur either as a result of concomitant immunosuppression (opportunistic infections, lymphoma and tumors), as a primary manifestation of HIV infection, or as an adverse effect of therapy (immune restoration and toxicity). These complications contribute largely to patient morbidity and mortality. In the era of highly active antiretroviral therapy (HAART) these disease states have changed in presentation, outcome and incidence. We review in detail the epidemiology, pathogenesis, clinical features, diagnosis, and management of these disorders.
authors.affiliation: Service de Neurologie, Fondation Adolphe de Rothschild, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Moulignier
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D000328:Adult; D000818:Animals; D002545:Brain Ischemia / Q000209:etiology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D002648:Child; D003586:Cytomegalovirus Infections / Q000150:complications / Q000453:epidemiology; D004198:Disease Susceptibility; D004660:Encephalitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D016919:Meningitis, Cryptococcal / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D009494:Neurosyphilis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology