Lipid peroxidation and antioxidant status in stomach cancer.
BACKGROUND
Considerable evidences have linked oxidative damage and cancer. In this article, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) activities, and malondialdehyde (MDA) and nitric oxide metabolites' levels (NO(x)) were investigated in patients with stomach cancer.


METHODS
All measurments were done by spectrophotometric techniques.


RESULTS
We observed a significant decrease in the activities of SOD and CAT in tumour tissues when compared with control tissues. The different of GSHPx activities and NO metabolite' levels were not statistically significant. MDA levels were significantly increased.


CONCLUSIONS
We conclude that increased MDA levels and decreased antioxidant enzyme activities can be valuable parameters in assessing the possible risk of cancer.
Batcioglu
Kadir
K
Department of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, Turkey. kadirbatci@inonu.edu.tr
Mehmet
Nihayet
N
Ozturk
I Cetin
IC
Yilmaz
Mehmet
M
Aydogdu
Nurettin
N
Erguvan
Rezzan
R
Uyumlu
Burcin
B
Genc
Metin
M
Karagozler
A Alev
AA
D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase