title: Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.
abstract: A series of chlamydocin analogs with various carbonyl functionalities were designed and synthesized as histone deacetylase (HDAC) inhibitors. Chlamydocin is a cyclic tetrapeptide containing an epoxyketone surrogate in the side chain which makes it irreversible inhibitor of HDACs, whereas apicidins are a class of cyclic tetrapeptides that contain an ethylketone moiety as zinc ligand. We replaced the epoxyketone moiety of chlamydocin with several ketones and aldehyde to synthesize potent reversible and selective HDAC inhibitors. The inhibitory activity of the cyclic tetrapeptides against histone deacetylase enzymes were evaluated and the result showed most of them are potent inhibitors. Some of them have remarkable selectivity among the HDACs.
authors.affiliation: Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.
authors.forename: Mohammed P I
authors.initials: MP
authors.lastname: Bhuiyan
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kato
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Okauchi
authors.forename: Norikazu
authors.initials: N
authors.lastname: Nishino
authors.forename: Satoko
authors.initials: S
authors.lastname: Maeda
authors.forename: Tomonori G
authors.initials: TG
authors.lastname: Nishino
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000447:Aldehydes; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D007659:Ketones; D008024:Ligands; D010456:Peptides, Cyclic; C102351:apicidin; C006963:chlamydocin; D015032:Zinc