Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats.
OBJECTIVE
To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD rats.


METHODS
In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats.


RESULTS
Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment.


CONCLUSIONS
We suggest that DA-9601 is a promising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increased mucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis.
Oh
Tae Young
TY
Dong-A Pharmaceutical Research Institute, 47-5, Sanggal-ri, Kiheung-up, Yongin-shi, Kyunggi-do 449-905, Korea. solemiooh@donga.co.kr
Shin
Chang Yell
CY
Sohn
Yong Sung
YS
Kim
Dong Hwan
DH
Ahn
Byoung Ok
BO
Lee
Eun Bang
EB
Park
Cho Hyun
CH
D000818:Animals; D019306:Artemisia; D002756:Cholagogues and Choleretics; D004383:Duodenogastric Reflux / Q000139:chemically induced / Q000150:complications*; D005756:Gastritis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013656:Taurocholic Acid
D002756:Cholagogues and Choleretics; C116959:DA 9601; D010936:Plant Extracts; D013656:Taurocholic Acid