Depression of insulin release by anti-GIP serum after oral glucose in rats.
An oral glucose tolerance test (OGTT), an OGTT after infusion of anti-gastric inhibitory polypeptide (GIP) serum, and an intravenous glucose infusion were performed in unrestrained and unanesthetized rats. In the rats treated with anti-GIP serum the insulin release was significantly depressed. This finding supports the concept that GIP is a physiologically important 'glucose-dependent insulin-releasing peptide'.
Lauritsen
B
B
Dept. of Surgical Gastroenterology, Hvidovre Hospital, Denmark.
Holst
J J
JJ
Moody
A J
AJ
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000172:deficiency / Q000276:immunology*; D005947:Glucose / Q000008:administration & dosage*; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000097:blood; D007106:Immune Sera / Q000494:pharmacology*; D007155:Immunologic Factors / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013549:Sweetening Agents / Q000008:administration & dosage*
D007106:Immune Sera; D007155:Immunologic Factors; D007328:Insulin; D013549:Sweetening Agents; D005749:Gastric Inhibitory Polypeptide; D005947:Glucose