title: Effect of body weight on testosterone/estradiol ratio in oligozoospermic patients.
abstract: To evaluate the effect of body mass on the hormonal and semen profiles of subfertile men with oligozoospemia, sperm concentration and reproductive hormone levels were compared in two body mass index (BMI) groups: underweight or normal weight patients (BMI = 25 kg/m2) vs. overweight or obese patients (BMI > 25 kg/m2). The mean BMI was 27 +/- 4.6 kg/m2. The testosterone/estradiol ratio was significantly reduced in the high BMI group as compared to the low BMI group (17 +/- 4 vs. 12 +/- 3; p < 0.05). A similar difference was found in the sperm concentration (11.2 +/- 3.16 x 10(6)/ml vs. 8.1 +/- 2.6 x 10(6)/ml). A nonsignificant difference was found in the LH/FSH ratio (1.41 +/- 0.64 vs. 1.63 +/- 0.72). We concluded that obesity and the consequent estrogen excess decrease the sperm concentration by influencing the hypothalamo-pituitary system.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine University of Szeged, Szeged, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Fejes
authors.forename: S
authors.initials: S
authors.lastname: Koloszár
authors.forename: Z
authors.initials: Z
authors.lastname: Závaczki
authors.forename: J
authors.initials: J
authors.lastname: Daru
authors.forename: J
authors.initials: J
authors.lastname: Szöllösi
authors.forename: A
authors.initials: A
authors.lastname: Pál
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D004958:Estradiol / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000150:complications; D009845:Oligospermia / Q000209:etiology / Q000503:physiopathology*; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone