title: [Generalized erythema triggered by a rapid decrease of basophils in chronic myeloid leukemia treated with imatinib].
abstract: A 57-year-old woman with chronic myeloid leukemia showing severe basophilia (WBC 17.1 X 10(9)/L, basophils 23%) was treated with 400mg imatinib in June 2003. A high basophil count (WBC 10.6 X 10(9)/L, basophils 31%) was still observed after 1 week of therapy. After 9 days of therapy, she developed generalized pruritic skin erythema, chills and high fever. After terminating imatinib treatment, prednisolone therapy was initiated. The rash quickly disappeared. Four days after withdrawal of imatinib, leukocyte count was 13.0 X 10(9)/L with 3% of basophils, suggesting the possibility that rapid decrease in basophils following imatinib therapy may induce severe cutaneous reactions.
authors.affiliation: First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu.
authors.forename: Motoko
authors.initials: M
authors.lastname: Sugito
authors.forename: Junichi
authors.initials: J
authors.lastname: Tsukada
authors.forename: Takehiro
authors.initials: T
authors.lastname: Higashi
authors.forename: Takanori
authors.initials: T
authors.lastname: Ohta
authors.forename: Ai
authors.initials: A
authors.lastname: Matsuura
authors.forename: Ayumu
authors.initials: A
authors.lastname: Kubota
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Mizobe
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Mouri
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Morimoto
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001491:Basophils; D001549:Benzamides; D004890:Erythema / Q000209:etiology*; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy*; D007964:Leukocytosis / Q000150:complications; D007970:Leukopenia / Q000139:chemically induced* / Q000150:complications; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects*; D011743:Pyrimidines / Q000009:adverse effects*; D012720:Severity of Illness Index
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate