Cytotoxic pregnane steroids from the formosan soft coral Stereonephthya crystalliana.
Nine new steroids, stereonsteroids A-I (1-9), were isolated from the methylene chloride solubles of the Formosan soft coral Stereonephthya crystalliana Kükenthal. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Wang
Shang-Kwei
SK
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Dai
Chang-Feng
CF
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011278:Pregnanes; D013256:Steroids