title: Thyrotoxicosis-induced prinzmetal variant angina.
abstract: We describe a postmenopausal women with new onset of variant angina caused by thyrotoxicosis due to Graves' disease. During exercise bicycle ergometry at 50 Watts, the patient developed typical angina with ST segment elevation in the precordial leads. A coronary angiogram revealed normal coronary arteries. Graves' disease with overt hyperthyroidism was diagnosed. After achieving an euthyroid state with administration of propylthiouracil, the symptoms resolved completely and the patient had a normal exercise capacity without electrocardiographic changes. Thus, we conclude that in patients with thyrotoxicosis, variant angina and normal coronary arteries, restoration of normal thyroid function may be curative.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Diabetes, University Hospital of Zürich, Switzerland. vojtech.pavlicek@usz.ch
authors.forename: V
authors.initials: V
authors.lastname: Pavlicek
authors.forename: H
authors.initials: H
authors.lastname: Zeif
authors.forename: F
authors.initials: F
authors.lastname: Widmer
mesh_terms: D000788:Angina Pectoris, Variant / Q000209:etiology* / Q000503:physiopathology; D013956:Antithyroid Agents / Q000627:therapeutic use; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008875:Middle Aged; D011441:Propylthiouracil / Q000627:therapeutic use; D013971:Thyrotoxicosis / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil