[Allergy-related hypereosinophilia].
Hypereosinophilia in the blood and tissues is one of the main characteristics of the pathophysiology of allergic disease. CD4+ T cells polarized to a Th2 phenotype mediate inflammatory disorders; cytokines produced by Th2, including IL-4, IL-5, and IL-13, drive the cardinal features of the disease. Recent human experiments indicate that eosinophils may control the bronchial remodeling that occurs in asthma. Eosinophils are a rich source of fibrogenic factors, particularly TGF-ss. Atopy is defined by abnormal IgE production in response to an allergen (an antigen that is then designated an allergen). Allergy combines pre-existent sensitization (atopy) with various symptoms - cutaneous, ENT, respiratory, or digestive. Atopy is diagnosed primarily by cutaneous skin-prick tests and the new multi-allergen blood test. A diagnosis of allergy requires the presence of symptoms and justifies workups for asthma, rhinitis, food allergies, or atopic dermatitis.
Garcia
Gilles
G
Service des explorations fonctionnelles respiratoires, Hôpital Antoine Béclère, Clamart. gilles.garcia@abc.aphp.fr
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D015267:Churg-Strauss Syndrome / Q000175:diagnosis; D003876:Dermatitis, Atopic / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis* / Q000209:etiology*; D005512:Food Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000209:etiology*; D006967:Hypersensitivity / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D011657:Pulmonary Eosinophilia / Q000139:chemically induced; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis; D012882:Skin Tests
D000485:Allergens; D007073:Immunoglobulin E