title: Nephron-sparing surgery for renal cell carcinoma: detailed analysis of complications over a 15-year period.
abstract: OBJECTIVE
  To assess the incidence of complications of conservative renal surgery for renal cell carcinoma in both elective and imperative indications, and its evolution over a 15 year period.
  
  
  METHODS
  From 1988 to 2003, 127 patients underwent partial nephrectomy or tumorectomy for renal cell carcinoma in our department. INDICATIONs were imperative in 42% (n = 53) and elective in 58% (n=74) of cases. Morbidity was retrospectively assessed according to four parameters: 1- Period of surgery: A, from 1988 to 1999 and B, from 2000 to 2003. 2- INDICATION: elective vs. imperative. 3- experience of surgeon: senior vs. junior. 4- Nature of complications: minor or major. Comparative analysis was conducted using Chi-square and Fischer exact tests.
  
  
  RESULTS
  Global incidence of complications was 30.7% (n = 39) corresponding to 18.1% minor (n = 23) and 12.6% (n = 16) major complications. Results show a moderate decrease of complication rate during Period B: 28.1% versus 32.9% during period A (p = 0.69). Complications occurred more frequently in imperative indications (49.1%) than in elective indications (17.6%) (p = 0.002), mostly regarding major complications (respectively 28.3% and 1.4%. (p < 0.001)). Overall re-intervention rate was 15.7%: 22.6% in imperative and 10.8% in elective indications (p = 0.008). Mean length of hospital stay was 14.1 days and significantly longer during period A (p = 0.003) and in imperative indications (p = 0.009).
  
  
  CONCLUSIONS
  In our study, conservative renal surgery has a significant rate of complications which is extremely variable regarding to different parameters. Most discriminating factor was indication: in imperative indications, we observed a high rate of major complications (28.3%) that we consider acceptable to prevent anephria in clearly informed patients. Major complications are exceptional in elective indications. Decreased incidence of complications during the later period (B) is modest, and the role played by systematic pedicular clampage is discussed. As results published in medical literature are difficult to compare, we agree with authors who recently proposed to standardize complications data analysis, using a gravity scale, in order to provide relevant information to patients about statistical risks before surgery.
authors.affiliation: Department of Urology and Transplantation, Edouard Herriot Hospital, University of Lyon, France. gilles.pasticier@chu-lyon.fr
authors.forename: G
authors.initials: G
authors.lastname: Pasticier
authors.forename: M-O
authors.initials: MO
authors.lastname: Timsit
authors.forename: L
authors.initials: L
authors.lastname: Badet
authors.forename: L
authors.initials: L
authors.lastname: De La Torre Abril
authors.forename: M
authors.initials: M
authors.lastname: Halila
authors.forename: H
authors.initials: H
authors.lastname: Fassi Fehri
authors.forename: M
authors.initials: M
authors.lastname: Colombel
authors.forename: X
authors.initials: X
authors.lastname: Martin
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D009392:Nephrectomy / Q000379:methods*; D011183:Postoperative Complications; D012086:Reoperation; D016896:Treatment Outcome; D014548:Urinary Fistula / Q000209:etiology*