title: Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius.
abstract: The arylnaphthalide lignan glycosides, taxodiifoloside, cleistanthoside A, cleistanthin A and cleistanthin A methyl ether, together with a triterpene, glochidone, have been isolated from the aerial parts of Phyllanthus taxodiifolius. The structures were established using spectral and chemical methods. Compounds and, as well as the derivatives and exhibited potent cytotoxic activities with GI50 values in the range of 10(-7)-10(-9) M in five cultured mammalian cancer cell lines while the new compound showed moderate activity (GI50 in the order of 10(-6) M). Compounds and were inactive in all tested cell lines.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand. scptc@mahidol.ac.th
authors.forename: Patoomratana
authors.initials: P
authors.lastname: Tuchinda
authors.forename: Anawat
authors.initials: A
authors.lastname: Kumkao
authors.forename: Manat
authors.initials: M
authors.lastname: Pohmakotr
authors.forename: Samaisukh
authors.initials: S
authors.lastname: Sophasan
authors.forename: Thawatchai
authors.initials: T
authors.lastname: Santisuk
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D002460:Cell Line; D005960:Glucosides / Q000302:isolation & purification; D006027:Glycosides / Q000302:isolation & purification; D017705:Lignans / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029803:Phyllanthus / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D006027:Glycosides; D017705:Lignans; D014315:Triterpenes; C509725:taxodiifoloside; C010088:cleistanthin