The role of gastric accommodation in the pathophysiology of functional dyspepsia.
OBJECTIVE
The pathophysiology of functional dyspepsia is not yet completely known. Several mechanisms have been suggested as having a role in symptom onset and impaired gastric accommodation to meal is one of the most frequent. This review will focus on the pathophysiological and clinical aspects of this abnormality.


METHODS
Medical peer-reviewed literature was considered to elucidate the role of gastric accommodation in the pathophysiology of functional dyspepsia.


BACKGROUND
Impaired gastric accommodation to meal is present in around 40% of patients with functional dyspepsia and it was shown to be associated with the presence of early satiety. Unfortunately, a definitive treatment of this abnormality with fundus-relaxing drugs is not yet available.


CONCLUSIONS
Further studies are needed to better clarify the role of each single pathophysiological mechanism on clinical manifestations of functional dyspepsia. Research is still ongoing to offer a valid therapeutic approach.
Di Stefano
M
M
Department of Medicine, University of Pavia, IRCCS "S. Matteo" Hospital, Pavia, Italy.
Miceli
E
E
Mazzocchi
S
S
Tana
P
P
Corazza
G R
GR
D004415:Dyspepsia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D004435:Eating / Q000502:physiology; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D012527:Satiation / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology*; D018170:Sumatriptan / Q000627:therapeutic use
D017366:Serotonin Receptor Agonists; D018170:Sumatriptan