[Regenerative therapy for damaged heart].
Regeneration therapy has currently emerged as one of the promising treatments for the patients suffering from severe heart dysfunction. Direct transplantation of isolated myoblasts or bone marrow mononuclear cells, and recruitment of stem cells from bone marrow by G-CSF administration have been already clinically performed. As further advanced therapy, research on fabricating three-dimensional (3-D) cardiac grafts by tissue engineering technology has also now begun. Most popular approach of tissue engineering is using 3-D biodegradable scaffolds as alternatives of extracellular matrix. By contrast, we have successfully fabricated macroscopically beating myocardial tissue by layering cell sheets which are harvested from intelligent culture dishes grafted with temperature-responsive polymer in nano-scale. These regenerative medicines should rescue many patients.
Shimizu
Tatsuya
T
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University.
D000818:Animals; D006333:Heart Failure / Q000601:surgery*; D051379:Mice; D009206:Myocardium / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*