[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer].
Molecular characterization of gastrointestinal cancer has greatly helped the definition of the key steps of the malignant transformation process and made it the best understood among the malignant cancers. Genetic influences on prognosis may have important implications for the management of the disease and help to design patient-tailored therapy. In order to acquire additional knowledge on this issue we have commenced an institutional study with the aim to identify the most frequent molecular alterations and make a correlation with the conventional histopathological parameters.
Leone
A
A
Anatomia Patologica e Chirurgia Generale Oncologica, AO San Camillo Forlanini, Roma.
Pisa
R
R
Gasbarra
R
R
Graziano
P
P
Remotti
D
D
Valle
M
M
Garofalo
A
A
D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D017353:Gene Deletion; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis; D009154:Mutation