title: Computed tomographic estimation of lung dimensions throughout the growth period.
abstract: The aim of the current study was to use computed tomography (CT) to estimate airway wall and lumen, and arterial and parenchyma dimensions in children throughout the growth period, and to provide normative data to study alterations caused by pulmonary disease. Clinical CT scans reported as normal that were performed in children for nonpulmonary and noncardiac reasons were analysed for lung weight, gas volume, lung expansion, lung surface/volume ratio, airway wall area, airway lumen area, airway lumen perimeter, arterial area and airway surface length/area ratio. The age range of the 50 subjects was 0-17.2 yrs. The data showed only little increase in lung expansion throughout childhood (n = 32). There was substantial variability in lung expansion between subjects. Airway wall and lumen and arterial area were exponentially associated with subjects' height (n = 50). Airway surface length/area ratio was linearly associated to alveolar surface/volume ratio. The data from the current study provide normative computed tomography estimates of airway wall and lumen, and arterial and parenchyma dimensions throughout the growth period that may be useful for the study of alterations in disease.
authors.affiliation: Erasmus MC-Sophia, Dept of Paediatric Pulmonology and Allergology, Rotterdam, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: de Jong
authors.forename: F R
authors.initials: FR
authors.lastname: Long
authors.forename: J C
authors.initials: JC
authors.lastname: Wong
authors.forename: P J
authors.initials: PJ
authors.lastname: Merkus
authors.forename: H A
authors.initials: HA
authors.lastname: Tiddens
authors.forename: J C
authors.initials: JC
authors.lastname: Hogg
authors.forename: H O
authors.initials: HO
authors.lastname: Coxson
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D016015:Logistic Models; D008168:Lung / Q000000981:diagnostic imaging* / Q000254:growth & development*; D008297:Male; D013902:Radiography, Thoracic; D012016:Reference Values; D014057:Tomography, X-Ray Computed