Reeler mutant mice exhibit seizures during recovery from isoflurane-induced anesthesia.
Reeler mice are a model of cortical malformation with enhanced seizure susceptibility. Data suggest that the propensity to anesthesia-induced seizures may be enhanced in animal models with developmental anomalies. Consequently, reeler mice were monitored behaviorally before, during and after isoflurane anesthesia. During recovery, 12% of reeler homozygotes had class I/II seizures while the remaining 88% exhibited convulsive seizures entailing opisthotonus and forepaw drumming. Similar behavior was not observed in controls. These data reveal that reeler mice display isoflurane-induced seizures and provide support for the hypothesis that developmental anomalies may predispose the central nervous system to anesthesia-induced seizures.
Kopjas
Nicholas N
NN
Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Jones
Ryan T
RT
Bany
Brent
B
Patrylo
Peter R
PR
D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000002:abnormalities*; D004195:Disease Models, Animal; D005260:Female; D005838:Genotype; D007530:Isoflurane / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics; D012640:Seizures / Q000139:chemically induced* / Q000235:genetics; D013045:Species Specificity
D018685:Anesthetics, Inhalation; D007530:Isoflurane