BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects.
BACKGROUND
A frequent polymorphism of the brain-derived neurotrophic factor (BDNF) gene (val(66)met) has been suggested to modulate hippocampal neuronal plasticity and has been associated with individual variations in emotional reactivity traits and episodic memory.


METHODS
The hippocampal formation was outlined in high-resolution anatomical magnetic resonance imaging (MRI) data in a sample of 36 healthy volunteers and compared between individuals as a function of the presence of the met-BDNF allele. Both whole-brain volume corrected and uncorrected data were tested for effects of genotype, sex, and age.


RESULTS
The met-BDNF allele was associated with an 11% reduction in the volume of the hippocampal formation.


CONCLUSIONS
In spite of a relatively small sample size, the presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region.
Bueller
Joshua A
JA
Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, USA.
Aftab
Macksood
M
Sen
Srijan
S
Gomez-Hassan
Diana
D
Burmeister
Margit
M
Zubieta
Jon-Kar
JK
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000704:Analysis of Variance; D001931:Brain Mapping; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D007839:Functional Laterality / Q000235:genetics; D005838:Genotype; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D014633:Valine / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine