title: DNA vaccines: successes and limitations in cancer and infectious disease.
abstract: Vaccination with plasmid DNA is an active area of investigation that is being applied to diseases including cancer and microbial pathogens associated with infectious diseases. Since its discovery, great progress has been made with the administration of DNA vaccines to initiate specific and effective immune responses against targeted illnesses. However, many obstacles still face its use in prophylactic and therapeutic vaccination scenarios. The nature of these difficulties alongside the successes and future of plasmid DNA will be discussed.
authors.affiliation: Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, 79430, USA.
authors.forename: Devin B
authors.initials: DB
authors.lastname: Lowe
authors.forename: Michael H
authors.initials: MH
authors.lastname: Shearer
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000627:therapeutic use; D003140:Communicable Disease Control / Q000379:methods*; D004195:Disease Models, Animal; D049673:History, 20th Century; D006801:Humans; D007114:Immunization; D016233:Immunotherapy, Active / Q000379:methods; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control*; D010957:Plasmids / Q000235:genetics / Q000276:immunology; D014611:Vaccination / Q000266:history / Q000379:methods; D019444:Vaccines, DNA / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D019444:Vaccines, DNA