GIP and insulin responses to oral glucose in coeliac patients before and after treatment.
The responses of plasma gastric inhibitory polypeptide (GIP) and insulin to oral glucose were studied in five patients with untreated coeliac disease. These patients were restudied after one year on a gluten-free diet. In the untreated patients, the blood glucose, serum insulin, and GIP levels were significantly lower than in the controls. After gluten withdrawal there was an improvement towards normality in the responses of blood glucose, serum insulin, and GIP. The results show that untreated coeliac disease is associated with abnormalities of intestinal and pancreatic hormone secretion and that these abnormalities are improved by gluten withdrawal.
Cooper
B T
BT
Nutritional and Intestinal Unit and Diabetic Clinic, General Hospital, Birmingham, England.
Walsh
C H
CH
Holmes
G K
GK
Wright
A D
AD
Cooke
W T
WT
Bloom
S R
SR
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002446:Celiac Disease / Q000097:blood* / Q000178:diet therapy* / Q000473:pathology; D000075202:Contraindications; D005260:Female; D005500:Follow-Up Studies; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage*; D005951:Glucose Tolerance Test; D005983:Glutens; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013549:Sweetening Agents / Q000008:administration & dosage*; D016896:Treatment Outcome
D001786:Blood Glucose; D007328:Insulin; D013549:Sweetening Agents; D005749:Gastric Inhibitory Polypeptide; D005983:Glutens; D005947:Glucose