title: Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease.
abstract: Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease.
  
  
  OBJECTIVE
  To test the hypothesis that regular exercise alters low-density lipoprotein (LDL) oxidability in patients with coronary artery disease.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  General hospital and community.
  
  
  METHODS
  Thirteen patients.
  
  
  METHODS
  Training program comprising running bouts twice weekly over 2 months.
  
  
  METHODS
  Plasma lipid profile, oxidized LDL, and rate (Ox(rate)) and amount (Ox(amount)) of LDL reaction products were measured at baseline and after 2 months of training. Brachial artery endothelium-dependent and -independent vasodilation was assessed by use of ultrasound.
  
  
  RESULTS
  Lipid profile and oxidized LDL remained unchanged, but mean Ox(rate) and Ox(amount) +/- standard deviation were reduced from 2.5+/-1.5nmol.mgLDL(-1).min(-1) and 120.3+/-75.3nmol/mgLDL at baseline to 0.4+/-0.2nmol.mgLDL(-1).min(-1) and 21.3+/-11.4nmol/mgLDL after training (P<.05), respectively. Brachial artery vasodilation was suggested to be improved, but statistical significance was not reached in the small cohort under study.
  
  
  CONCLUSIONS
  Aerobic training enhances the resistance of LDL to oxidation in patients with coronary artery disease, which may play a role in the favorable effects of exercise.
authors.affiliation: Department of Angiology, Medical University of Vienna, Austria. sophie.ziegler@meduniwien.ac.at
authors.forename: Sophie
authors.initials: S
authors.lastname: Ziegler
authors.forename: Georg
authors.initials: G
authors.lastname: Schaller
authors.forename: Friedrich
authors.initials: F
authors.lastname: Mittermayer
authors.forename: Johannes
authors.initials: J
authors.lastname: Pleiner
authors.forename: Judith
authors.initials: J
authors.lastname: Mihaly
authors.forename: Alexander
authors.initials: A
authors.lastname: Niessner
authors.forename: Bernhard
authors.initials: B
authors.lastname: Richter
authors.forename: Sabine
authors.initials: S
authors.lastname: Steiner-Boeker
authors.forename: Martina
authors.initials: M
authors.lastname: Penak
authors.forename: Barbara
authors.initials: B
authors.lastname: Strasser
authors.forename: Michael
authors.initials: M
authors.lastname: Wolzt
mesh_terms: D001916:Brachial Artery / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000378:metabolism / Q000503:physiopathology / Q000534:rehabilitation*; D015444:Exercise; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012420:Running; D014664:Vasodilation
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein