title: Sunflower seed oil-enriched product can inhibit Ehrlich solid tumor growth in mice.
abstract: BACKGROUND
  Sunflower seed oil (SSO) effect on solid and ascitic forms of Ehrlich tumor was evaluated.
  
  
  METHODS
  Solid or ascitic Ehrlich tumor-bearing Swiss mice were treated daily, by subcutaneous route, with 200 microl of SSO. The solid tumor-bearing footpad was measured every 3 days and ascitic tumor-bearing mice had their ascites collected and quantified. At the end of the SSO treatment, the total cell number in lymphoid organs was quantified.
  
  
  RESULTS
  Subcutaneous treatment with SSO inhibits the solid tumor growth and increases lymph node cell number in animals with solid tumor, but has no effect on animals with ascitic tumor.
  
  
  CONCLUSIONS
  SSO can delay the solid tumor growth, possibly due to better absorption of this treatment by draining lymph nodes.
authors.affiliation: Laboratory of Immunophysiology, Department of Pathology, Federal University of Maranhão, São Luís, Brazil.
authors.forename: Lucilene A
authors.initials: LA
authors.lastname: Silva
authors.forename: Kátia A F
authors.initials: KA
authors.lastname: Nascimento
authors.forename: Márcia C G
authors.initials: MC
authors.lastname: Maciel
authors.forename: Mayara T
authors.initials: MT
authors.lastname: Pinheiro
authors.forename: Paulo R A
authors.initials: PR
authors.lastname: Sousa
authors.forename: Susanne C P
authors.initials: SC
authors.lastname: Ferreira
authors.forename: Ana Paula S
authors.initials: AP
authors.lastname: Azevedo
authors.forename: Rosane N M
authors.initials: RN
authors.lastname: Guerra
authors.forename: Flávia R F
authors.initials: FR
authors.lastname: Nascimento
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D007279:Injections, Subcutaneous; D051379:Mice; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D000074242:Sunflower Oil
chemical_list: D010938:Plant Oils; D000074242:Sunflower Oil