Cybil induced hepatobiochemical changes in wistar rats.
Cybil, 25%EC formulation of Cypermethrin, induces biochemical changes in the liver of wistar rats after oral intubation of the same at acute (one day) and subacute (7, 14 and 21 days) levels. The changes were tallied with the controls run simultaneously. LD50 of Cybil was estimated to be 622mg/kg body weight The acute dose is 80mg/kg body weight exposed for one day i.e. 24 hours and subacute dose is 4mg/kg body weight exposed for 7, 14 and 21 days. When compared with the control values, both the doses enhanced the level of glycogen, cholesterol, total lipid and acid phosphatase activities, while decreased activity of alkaline phosphatase. Alterations in glycogen, cholesterol, total lipid, acid phosphatase and alkaline phosphatase resulted in the impairement in liver physiology.
Singh
Vijay Kr
VK
Toxicology lab, Department of Zoology, School of Life Sciences, Dr. B.R.Amedkar University, Agra-282 002, India.
Dixit
Poonam
P
Saxena
Prabhu N
PN
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006003:Glycogen / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007306:Insecticides; D008055:Lipids; D011722:Pyrethrins; C017160:cypermethrin; D006003:Glycogen; D002784:Cholesterol; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase