Encapsulation of quinine by beta-cyclodextrin: excellent model for mimicking enzyme-substrate interactions.
An inclusion complex formed by beta-cyclodextrin and quinine has been investigated in solution and in the solid state, in which the quinoline ring and the aliphatic ring locate in different hydrophobic cavities, respectively. The study on the inclusion geometry and weak interactions shows that the difference in conformation for this complex is a result of three main packing arrangement considerations, which can provide an ideal model mimicking enzyme-substrate interactions.
Fan
Zhi
Z
College of Sciences, Tianjin University of Science and Technology, Tianjin 300071, PRC. zhifan@public.tpt.tj.cn
Diao
Chun-Hua
CH
Song
Hai-Bin
HB
Jing
Zuo-Liang
ZL
Yu
Ming
M
Chen
Xin
X
Guo
Min-Jie
MJ
D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D011803:Quinine / Q000737:chemistry* / Q000378:metabolism*; D013379:Substrate Specificity; D047392:beta-Cyclodextrins / Q000737:chemistry*
D047392:beta-Cyclodextrins; D011803:Quinine