title: The complex between activated protein C and protein C inhibitor: A clinically useful indicator of aortic aneurysms?
abstract: The concentration of the complex between activated protein C and the protein C inhibitor reflects the degree of activation of blood coagulation. A sandwich method has been devised that measures the complex concentration in blood plasma. A key feature of the method is that the catching monoclonal antibody recognizes a complex-dependent neoepitope in PCI, which is a prerequisite, since the concentration of uncomplexed PCI is approximately 10(4)-fold higher than that of the complex. In patients with atherosclerotic disease, those with aortic aneurysms exhibit a three-fold increase in complex concentration compared to that of normal subjects.
authors.affiliation: Department of Clinical Chemistry, Lund University, University Hospital, Malmö, S205 02 Malmö, Sweden. Johan.Stenflo@klkemi.mas.lu.se
authors.forename: J
authors.initials: J
authors.lastname: Stenflo
authors.forename: M
authors.initials: M
authors.lastname: Kjellberg
authors.forename: K
authors.initials: K
authors.lastname: Strandberg
authors.forename: P J
authors.initials: PJ
authors.lastname: Svensson
authors.forename: T
authors.initials: T
authors.lastname: Kölbel
authors.forename: B
authors.initials: B
authors.lastname: Lindblad
mesh_terms: D001014:Aortic Aneurysm / Q000175:diagnosis*; D015415:Biomarkers; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D046912:Multiprotein Complexes / Q000032:analysis*; D011486:Protein C / Q000378:metabolism*; D018046:Protein C Inhibitor / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D046912:Multiprotein Complexes; D011486:Protein C; D018046:Protein C Inhibitor