Linking molecular motors to Alzheimer's disease.
It is currently thought that Alzheimer's disease develops due to aberrant generation of amyloid-beta peptides. However, the mechanisms underlying the aberrant generation of amyloid-beta peptides remain unknown. An emerging concept suggests that impaired axonal transport may play a pivotal role in the aberrant generation of amyloid-beta peptides. Here we review and discuss advances in understanding AD with the primary focus on the possible role of molecular motors and axonal transport in its pathogenesis.
Stokin
Gorazd B
GB
Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center, Zaloska Cesta 7, SI-1525 Ljubljana, Slovenia.
Goldstein
Lawrence S B
LS
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*
D016564:Amyloid beta-Protein Precursor; D020409:Molecular Motor Proteins