Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis.
Several genetic polymorphisms have been identified in patients with sepsis and severe sepsis, such as the tumor necrosis factor-alpha (TNF-alpha) and TNF-beta genes, the interleukin-1 (IL-1) family, the IL-6, the IL-10, the CD-14, the Toll-like receptors, plasminogen activator inhibitor type 1, and the factor V 1691G-A mutations. In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied. TNF-alpha 308 G/A, PAI-1 4G/4G, and EPCR mutations influence the risk of severe sepsis in children. IL-6 174 G/C, FVL, and Cathepsin G (Ars 125 Ser) did not influence the incidence and mortality of severe sepsis.
Sipahi
Tansu
T
Department of Pediatric Hematology, Fatih University, Faculty of Medicine, Ankara, Turkey. tansusipahi@hotmail.com
Pocan
Hatice
H
Akar
Nejat
N
D000293:Adolescent; D015703:Antigens, CD / Q000235:genetics; D056649:Cathepsin G; D002403:Cathepsins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D000074283:Endothelial Protein C Receptor; D005165:Factor V / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000235:genetics; D017720:Molecular Epidemiology; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics; D018805:Sepsis / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics; D017741:Survivors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; D015850:Interleukin-6; C478370:PROCR protein, human; D017395:Plasminogen Activator Inhibitor 1; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; C095381:factor V Leiden; D005165:Factor V; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G