[Research of 99mTcO4- and 99mTcO2- in injectable solutions of 99mTc-HMDP by inverse phase HPTLC].
Bone scintigraphy allows the diagnostic of many pathologies related to bone through the intravenous administration of a phosphonate bone marker complexed to 99 metastable technetium (99mTc). The instability of these injectable solutions on contact with air can lead to a mixture of pertechnetate VII (99mTcO4-) and technetium IV (99mTcO2-, xH2O), technetium IV being the only derivative to fix bone. A qualitative control of the purity of these solutions proved to be consequently important before administration. We report here the perfecting of a new chromatographic test based on reverse phase high performance thin layer chromatography (HPTLC). This test, simple, rapid and reproductive allows without ambiguity the detection of 99mTcO4-(VII) and 99mTcO2-(IV), xH2O in hydroxymethylene diphosphonate (HMDP) injectable solutions ready to use.
Jacquot
Y
Y
Service de médecine nucléaire, Chu Jean-Minjoz, 3, boulevard Fleming, F25000 Besançon. jacquot@ccr.jussieu.fr
Zoubir
Br
B
Xicluna
A
A
Bidet
A-Cl
AC
D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002851:Chromatography, High Pressure Liquid; D019999:Pharmaceutical Solutions; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D013670:Sodium Pertechnetate Tc 99m / Q000138:chemical synthesis* / Q000737:chemistry; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D019999:Pharmaceutical Solutions; D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013670:Sodium Pertechnetate Tc 99m; D013669:Technetium Tc 99m Medronate