title: Adrenocortical adenoma with rhabdoid features.
abstract: We report a case of an aldosterone producing adrenocortical adenoma with rhabdoid features in a 16-year-old girl. Grossly, the tumor measured 30 mm in diameter and weighed 24 g. Histologically, the tumor was composed of approximately equal parts of tumor cells with rhabdoid features arranged in a solid and trabecular pattern and cells characterized by compact eosinophilic cytoplasm, solid growth with focal necroses, and increased mitotic activity. The lipid-rich tumor cells with ample clear vacuolized cytoplasm represent a minor component. Immunohistochemically, all the tumor cells showed the same results and were positive for vimentin, synaptophysin, Melan A, and alpha-inhibin. Cytokeratin CAM 5.2 was positive only focally. Chromogranin A, actin, alpha-actin, S100 protein, EMA, and cytokeratin AE1/AE3 were negative. Rhabdoid features have been described in many tumors of variable histogenesis; however, to the best of our knowledge, the presence of rhabdoid phenotype has never been described in either adrenocortical adenoma or carcinoma.
authors.affiliation: Department of Pathology, 1st Medical Faculty, Charles University, Studnickova 2, Prague 12800, Czech Republic. pdundr@seznam.cz
authors.forename: Pavel
authors.initials: P
authors.lastname: Dundr
authors.forename: Ctibor
authors.initials: C
authors.lastname: Povýsil
authors.forename: Tomás
authors.initials: T
authors.lastname: Zelinka
authors.forename: Daniel
authors.initials: D
authors.lastname: Tvrdík
authors.forename: Vanda
authors.initials: V
authors.lastname: Ciprová
authors.forename: Kvetoslav
authors.initials: K
authors.lastname: Novák
mesh_terms: D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000378:metabolism / Q000473:pathology*; D000315:Adrenalectomy; D018246:Adrenocortical Adenoma / Q000473:pathology* / Q000601:surgery; D000450:Aldosterone / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018335:Rhabdoid Tumor / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D000450:Aldosterone