title: Two new abietane diterpenoids from Salvia yunnanensis.
abstract: Two new abietane diterpenoids, yunnannin A and danshenol C, were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A, przewalskin, tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound showed inhibited growth of K562 (IC50=0.53 microg/mL), T-24 (IC50=7.94 microg/mL), QGY (IC50=4.65 microg/mL) and Me180 (IC50=6.89 microg/mL) cell lines while compound was inactive. Compound showed moderate inhibitory activity on QGY (IC50=16.75 microg/mL) and Me180 (IC50=5.84 microg/mL) cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Lei
authors.initials: L
authors.lastname: Lu
authors.forename: Zi-Ying
authors.initials: ZY
authors.lastname: Weng
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D027544:Salvia / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic