[About the peculiar form of radiation induced genome instability].
The usually studied forms of the induced genome instability manifested as a steady change of mutability of proliferated cells, we compared with its peculiar form characterized by the inherited irreversible increase of the level of spontaneous damage of cells. These effects appear of the moment of reaching of the dose threshold according to the "all or nothing" principle, just after the relatively low-dose radiational action. These changes occur without association with the cell division and thereby have an exclusive significance in the pathogenesis of the radiational damage of low-renewing mammalian tissues. It is suggested that the considered changes could underlie the development of the delayed non-cancerogenic somatic postradiational sequelae and of the acceleration of natural aging.
Bychkovskaia
I B
IB
Gil'iano
N Ia
NIa
Fedortsova
R F
RF
Bedcher
F S
FS
D000375:Aging / Q000528:radiation effects; D000656:Amoeba / Q000528:radiation effects; D000818:Animals; D016678:Genome / Q000528:radiation effects*; D042822:Genomic Instability; D011839:Radiation, Ionizing