title: Features of regression in dermoscopic diagnosis: a confounding factor? Two clinical, dermoscopic-pathologic case studies.
abstract: BACKGROUND
  In dermoscopy, the presence of regression areas is generally associated with melanocytic lesions and is often considered a clue of malignancy. However, some lesions included in the differential diagnosis of melanoma may show dermoscopic regression parameters. Regression may indeed be one of the most confounding dermoscopic parameters because it tends to cover, or rather to destroy, other parameters, thus often hindering a correct diagnosis.
  
  
  OBJECTIVE
  We propose to raise the issue of the actual diagnostic role of this parameter.
  
  
  METHODS
  We discuss two clinical cases (melanoma and basal cell carcinoma) with major dermoscopic regression features.
  
  
  CONCLUSIONS
  Dermoscopic regression parameters should not be regarded as almost pathognomonic signs of melanocytic lesions. Rather, they should be taken into account only after having considered other dermoscopic parameters of greater diagnostic significance and just as signs that may better typify the lesion.
authors.affiliation: Department of Dermatology, University of Florence, Florence, Italy. dermoncologia@unifi.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: de Giorgi
authors.forename: Daniela
authors.initials: D
authors.lastname: Massi
authors.forename: Camilla
authors.initials: C
authors.lastname: Salvini
authors.forename: Serena
authors.initials: S
authors.lastname: Sestini
authors.forename: Paolo
authors.initials: P
authors.lastname: Carli
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000473:pathology*; D046169:Dermoscopy; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology*; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*