[Evaluation of sialometry and minor salivary gland biopsy in classification of Sjögren's Syndrome patients].
Sjögren's Syndrome is an autoimmune disease of the exocrine glands, mainly salivary and lachrymal glands. There is no gold standard test for diagnosis.


OBJECTIVE
evaluation of the importance of minor salivary gland biopsy and sialometry, isolated or associated, as methods for classification of Sjögren's Syndrome.


METHODS
Transversal cohort.


METHODS
Seventy-two patients that reported dry mouth from January 1997 to September 2003 were investigated and classified, based on the established criteria. Non-stimulated sialometry was performed by the swab technique. Histopathology exams were evaluated for the presence of inflammatory focus.


RESULTS
Non-stimulated sialometry and minor salivary gland biopsy presented different sensitivities for primary Sjögren's Syndrome and for secondary Sjögren's Syndrome. Focal sialadenitis with higher focus score was characteristic of primary Sjögren's Syndrome. Biopsy and sialometry were compared and it was observed that specificity and positive predictive value of biopsy were higher. Comparing biopsy and biopsy associated with sialometry, it was observed that biopsy had higher sensitivity and negative predictive value. Specificity of biopsy associated with sialometry was higher. Comparing sialometry and biopsy associated with sialometry, it was observed that biopsy associated with sialometry presented higher positive predictive value and higher specificity. Sialometry's sensitivity was higher.


CONCLUSIONS
Sialometry and biopsy tests presented different performances in primary Sjögren's Syndrome and secondary Sjögren's Syndrome; the positivity of the association of both tests increases the specificity for Sjögren's Syndrome (95%).
de Azevedo
Bianca Benatti
BB
UNIFESP.
Bussoloti Filho
Ivo
I
D001172:Arthritis, Rheumatoid / Q000150:complications; D001706:Biopsy; D004812:Epidemiologic Methods; D006801:Humans; D012463:Saliva / Q000737:chemistry*; D012470:Salivary Glands, Minor / Q000473:pathology*; D012472:Salivation; D012859:Sjogren's Syndrome / Q000209:etiology / Q000473:pathology*