Open sesame! Coxsackieviruses conspire to trespass the tight junctional gate.
In the January 13 issue of Cell, Coyne and Bergelson describe an "Open sesame!" strategy developed by coxsackieviruses to invade the organism through the intestinal epithelium. The strategy involves coopting intrinsic signaling abilities of the apical GPI-anchored protein DAF to open the tight junction barrier, gain access to the primary receptor CAR, and activate virus internalization by a caveolin-dependent pathway.
Diaz
Fernando
F
Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, LC-300, New York, NY 10024, USA.
Rodriguez-Boulan
Enrique
E
D001665:Binding Sites; D018958:CD55 Antigens / Q000502:physiology; D029822:Enterovirus B, Human / Q000472:pathogenicity*; D006801:Humans; D007413:Intestinal Mucosa / Q000821:virology; D008954:Models, Biological; D019108:Tight Junctions / Q000821:virology*
D018958:CD55 Antigens