Nasal airflow recovery after decongestion test is associated with bronchial hyperreactivity in patients with allergic rhinitis.
BACKGROUND
The decongestion test involves spraying an intranasal vasoconstrictor drug to evaluate the recovery of nasal airflow.


OBJECTIVE
The aim of this study was to assess the relationship between pulmonary function (assessed by spirometry and methacholine challenge) and nasal airflow recovery after a topical vasoconstrictor had been administered in patients with allergic rhinitis (perennial, seasonal, or mixed allergic rhinitis).


METHODS
A total of 150 subjects were studied. The total symptom score, sensitization, and pulmonary function were all assessed. All subjects underwent rhinomanometry and the decongestion test.


RESULTS
Univariate analysis revealed that nasal symptoms and spirometric parameters (except FEF(25-75) in subjects with seasonal allergic rhinitis) were not. Only bronchial hyperreactivity, assessed by methacholine challenge, proved to be significantly (and independently) associated with outcome (OR 1.45, P = 0.025).


CONCLUSIONS
This study provides the first evidence of an association between a positive response to the decongestion test and bronchial hyperreactivity, assessed by methacholine challenge, in patients with allergic rhinitis.
Ciprandi
Giorgio
G
Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. gio.cip@libero.it
Cirillo
Ignazio
I
Klersy
Catherine
C
Vizzaccaro
Andrea
A
Tosca
Maria Angela
MA
Marseglia
Gian Luigi
GL
D000328:Adult; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D006801:Humans; D008297:Male; D009666:Nose / Q000503:physiopathology*; D012220:Rhinitis; D012221:Rhinitis, Allergic, Perennial / Q000503:physiopathology*; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D013147:Spirometry