Analysis of Mycobacterium leprae genome: in silico searching for drug targets.
The author performed a database search to find the recorded complete genes with complete sequences of Mycobacterium leprae and studied their homology to human genomes by BLAST method. From a total of 35 genes, the potential candidates for further target-based drug development were identified.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
D000942:Antigens, Bacterial; D030541:Databases, Genetic; D016503:Drug Delivery Systems; D018390:Gene Targeting; D016680:Genome, Bacterial / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007918:Leprosy / Q000382:microbiology* / Q000517:prevention & control; D009166:Mycobacterium leprae / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D017385:Sequence Homology; D013785:Thailand / Q000453:epidemiology
D000942:Antigens, Bacterial