title: Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.
abstract: A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics.
authors.affiliation: Genomics Institute of the Novartis Research Foundation (GNF), 10715 John Jay Hopkins Drive, San Diego, CA 92121, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Kelli L
authors.initials: KL
authors.lastname: Kuhen
authors.forename: Karen
authors.initials: K
authors.lastname: Wolff
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.forename: Kimberly
authors.initials: K
authors.lastname: Bieza
authors.forename: Jeremy
authors.initials: J
authors.lastname: Caldwell
authors.forename: Badry
authors.initials: B
authors.lastname: Bursulaya
authors.forename: Tove
authors.initials: T
authors.lastname: Tuntland
authors.forename: Kanyin
authors.initials: K
authors.lastname: Zhang
authors.forename: Donald
authors.initials: D
authors.lastname: Karanewsky
authors.forename: Yun
authors.initials: Y
authors.lastname: He
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D015195:Drug Design; D024882:Drug Resistance, Viral; D015497:HIV-1 / Q000187:drug effects*; D007211:Indoles / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D007211:Indoles; D018894:Reverse Transcriptase Inhibitors