Sertoli-Leydig cell tumour in a postmenopausal woman showing all facets of the insulin resistance syndrome (IRS).
Sertoli-Leydig cell tumours are rare sex stromal tumours with an incidence of < 0.5% of all ovarian tumours. Most frequently this tumour occurs in young women with a history of amenorrhoea, hirsutism and lowered pitch. Here, we report on a woman with IRS, postmenopausal virilization and increased testosterone levels due to a Sertoli-Leydig cell tumour. This is the first case to suggest an association between IRS and Sertoli-Leydig cell tumours. Furthermore, we highlight the difficulties in detecting this ovarian tumour with sonography.
Dahlgren
Eva
E
Department of Obstetrics and Gynecology, the Sahlgrenska Academy at Göteborg University, Sweden. eva.dahlgren@vgregion.se
Gull
Berit
B
Willén
Roger
R
Sundler
Frank
F
Rosén
Thord
T
Jansson
Per-Anders
PA
D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007333:Insulin Resistance; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D018310:Sertoli-Leydig Cell Tumor / Q000150:complications* / Q000473:pathology*