Phosphoinositide 3-kinase controls early and late events in mammalian cell division.
Phosphoinositide 3-kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin-dependent kinases. Fine-tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer.
García
Zaira
Z
Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain.
Kumar
Amit
A
Marqués
Miriam
M
Cortés
Isabel
I
Carrera
Ana C
AC
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015398:Signal Transduction
D019869:Phosphatidylinositol 3-Kinases; D018844:Cyclin-Dependent Kinases