title: [Systemic validation of clinical practice guidelines: the AGREE network].
abstract: BACKGROUND
  Over recent decades, the number of available clinical practice guidelines has enormously grown. Guidelines should meet specific quality criteria to ensure good quality. There is a growing need for the developement of a set of criteria to ensure that potential biases inherent in guideline development have been properly addressed and that the recommendations for practice are valid and reliable.
  
  
  OBJECTIVE
  The AGREE-collaboration is an international network that developed an instrument to critically appraise the methodological quality of guidelines. AGREE promotes a clear strategy to produce, disseminate and evaluate guidelines of high quality.
  
  
  METHODS
  In the first phase of the international project the AGREE-instrument was tested in 11 different countries. Based on this experience the instrument was refined and optimised. In the second phase it was disseminated, promoted and evaluated in 18 participating countries. Belgium was one of them.
  
  
  RESULTS
  The Belgian partner in the AGREE-project developed 3 workshops and established 13 validation committees to validate guidelines from Belgian developer groups. We collected 33 questionnaires from participants of the workshops and the validation committees, in which we asked for primary experiences and information on the usefulness and applicability of the instrument. We were also interested in the shortcomings of the instrument and potential strategies to bridge them.
  
  
  CONCLUSIONS
  More efforts should be made to train methodological experts to gain certain skills for a critical appraisal of clinical practice guidelines. Promoting the AGREE-instrument will lead to a broader knowledge and use of quality criteria in guideline development and appraisal.
  
  
  CONCLUSIONS
  The development and dissemination of an international list of criteria to appraise the quality of guidelines will stimulate the development of methodologically sound guidelines. International comparisons between existing guidelines will lead to a better collaboration between guideline developers throughout the world.
authors.affiliation: Centre Belge d'Evidence-Based Medicine (CEBAM). karin.hannes@med.kuleuven.ac.be
authors.forename: K
authors.initials: K
authors.lastname: Hannes
authors.forename: P
authors.initials: P
authors.lastname: Van Royen
authors.forename: B
authors.initials: B
authors.lastname: Aertgeerts
authors.forename: F
authors.initials: F
authors.lastname: Buntinx
authors.forename: D
authors.initials: D
authors.lastname: Ramaekers
authors.forename: P
authors.initials: P
authors.lastname: Chevalier
mesh_terms: D002170:Canada; D005062:European Union; D019317:Evidence-Based Medicine; D006801:Humans; D007391:International Cooperation; D017410:Practice Guidelines as Topic / Q000592:standards*