title: Deoxycholate amphotericin B and amphotericin B lipid complex exert additive antifungal activity in combination with pulmonary alveolar macrophages against Fusarium solani.
abstract: Fusarium spp. have emerged as important causes of invasive fungal infections in immunocompromised patients. Rabbit pulmonary alveolar macrophages (PAMs) exhibited fungicidal activity against conidia of Fusarium solani and achieved a time-dependent increase in killing. Neither deoxycholate amphotericin B (DAMB) nor amphotericin B lipid complex (ABLC) exerted a suppressive effect on PAMs by decreasing their conidiocidal activity against F. solani. On the contrary, at a concentration of 0.125 microg ml(-1), ABLC and, to a lesser degree, DAMB additively augmented the fungicidal activity of pulmonary alveolar macrophages against conidia of Fusarium solani.
authors.affiliation: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MA, USA.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roilides
authors.forename: Caron A
authors.initials: CA
authors.lastname: Lyman
authors.forename: Derek
authors.initials: D
authors.lastname: Armstrong
authors.forename: Theodouli
authors.initials: T
authors.lastname: Stergiopoulou
authors.forename: Ruta
authors.initials: R
authors.lastname: Petraitiene
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D003840:Deoxycholic Acid / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D005670:Fusarium / Q000187:drug effects* / Q000276:immunology*; D006801:Humans; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000276:immunology*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010715:Phosphatidylglycerols / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination