Reduction in incidence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection in an intensive care unit: role of treatment with mupirocin ointment and chlorhexidine baths for nasal carriers of MRSA.
After the introduction of routine treatment for every nasal carrier of methicillin-resistant Staphylococcus aureus, active follow-up surveillance for nosocomial methicillin-resistant S. aureus infection was conducted for 5 years in an intensive care unit of a tertiary-care teaching hospital. There was a significant decrease in the incidence of nosocomial methicillin-resistant S. aureus infection during the later years of follow-up. Decolonization of nasal carriers of methicillin-resistant S. aureus is probably associated with such findings.
Sandri
Ana Maria
AM
Infection Control Department, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, 6690 Ipiranga Avenue, Porto Alegre, RS 90610-000, Brazil.
Dalarosa
Micheline Gisele
MG
Ruschel de Alcantara
Luciana
L
da Silva Elias
Laura
L
Zavascki
Alexandre Prehn
AP
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000627:therapeutic use; D001938:Brazil; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000627:therapeutic use; D003428:Cross Infection / Q000517:prevention & control; D006801:Humans; D017053:Infection Control / Q000379:methods; D007362:Intensive Care Units; D016106:Methicillin Resistance; D016712:Mupirocin / Q000008:administration & dosage* / Q000627:therapeutic use; D009666:Nose / Q000382:microbiology*; D009824:Ointments; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D009824:Ointments; D016712:Mupirocin; D002710:Chlorhexidine