Calcium-activated potassium channels and the regulation of vascular tone.
Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium signals and targets represent multilayered opportunities for prevention and/or treatment of vascular dysfunctions.
Ledoux
Jonathan
J
Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont, USA.
Werner
Matthias E
ME
Brayden
Joseph E
JE
Nelson
Mark T
MT
D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D024681:Potassium Channels, Calcium-Activated / Q000145:classification / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction
D024681:Potassium Channels, Calcium-Activated; D002118:Calcium