title: High levels of active quiescin Q6 sulfhydryl oxidase (QSOX) are selectively present in fetal serum.
abstract: The participation of thiol-oxidoreductases such as thioredoxin during implantation, embryogenesis and fetal development has been extensively studied. Here, we analyzed the expression of the thioredoxin superfamily enzyme quiescin Q6/sulfhydryl oxidase (QSOX) during development. Results show that QSOX is present in fetal bovine serum (4 months' gestation), but its levels decrease with time after birth (from P1 to P60). We also demonstrate that a sulfhydryl oxidase activity correlates with QSOX expression in such sera, suggesting a putative role in the redox modulation of developmental programs.
authors.affiliation: Department of Basic Pathology, Universidade Federal do Paraná, Curitiba, Brazil.
authors.forename: S M
authors.initials: SM
authors.lastname: Zanata
authors.forename: A C
authors.initials: AC
authors.lastname: Luvizon
authors.forename: D F
authors.initials: DF
authors.lastname: Batista
authors.forename: C M
authors.initials: CM
authors.lastname: Ikegami
authors.forename: F O
authors.initials: FO
authors.lastname: Pedrosa
authors.forename: E M
authors.initials: EM
authors.lastname: Souza
authors.forename: D F S
authors.initials: DF
authors.lastname: Chaves
authors.forename: L F
authors.initials: LF
authors.lastname: Caron
authors.forename: J V
authors.initials: JV
authors.lastname: Pelizzari
authors.forename: F R M
authors.initials: FR
authors.lastname: Laurindo
authors.forename: L S
authors.initials: LS
authors.lastname: Nakao
mesh_terms: D000818:Animals; D002417:Cattle; D005312:Fetal Blood / Q000201:enzymology*; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000096:biosynthesis; D013879:Thioredoxins / Q000096:biosynthesis*; D013997:Time Factors; D050862:Oxidoreductases Acting on Sulfur Group Donors
chemical_list: D010088:Oxidoreductases; D013879:Thioredoxins; D050862:Oxidoreductases Acting on Sulfur Group Donors