title: Pulmonary mycobacteriosis in a patient affected by mycosis fungoides: a diagnostic and therapeutic challenge.
abstract: Among patients with cutaneous T-cell lymphoma (CTCL), sepsis and pulmonary infections are the first cause of death. We report on a patient with CTCL who, after more than 10 years of aggressive antineoplastic treatments, showed extensive pulmonary infiltrations on staging CT scan. Repeated CT scans were inconclusive for an infectious process, and the patient was still asymptomatic. The diagnosis of mycobacteriosis was made on the microbiologic exam of bronchoalveolar lavage. Specific treatment was started with contemporary dosage reduction of chemotherapy. After six months of antibiotic treatment the pulmonary lesions improved, whereas CTCL progressed. Therefore, a new antineoplastic regimen was started obtaining control of CTCL, without aggravation of the pulmonary lesions. We highlight the diagnostic and therapeutic pitfalls encountered when pulmonary mycobacteriosis complicates the course and treatment of CTCL.
authors.affiliation: Department of Dermatology, University of Rome La Sapienza, Viale del Policlinico, 155 00161 Rome, Italy. riccardoborroni@gmail.com
authors.forename: R G
authors.initials: RG
authors.lastname: Borroni
authors.forename: U
authors.initials: U
authors.lastname: Bottoni
authors.forename: V
authors.initials: V
authors.lastname: Devirgiliis
authors.forename: V
authors.initials: V
authors.lastname: Panasiti
authors.forename: M
authors.initials: M
authors.lastname: Mancini
authors.forename: M
authors.initials: M
authors.lastname: Curzio
authors.forename: M
authors.initials: M
authors.lastname: Rossi
authors.forename: M
authors.initials: M
authors.lastname: Venditti
authors.forename: M
authors.initials: M
authors.lastname: Martelli
authors.forename: S
authors.initials: S
authors.lastname: Delia
authors.forename: R
authors.initials: R
authors.lastname: Clerico
authors.forename: S
authors.initials: S
authors.lastname: Calvieri
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D009161:Mycobacterium / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D009164:Mycobacterium Infections / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology*; D009182:Mycosis Fungoides / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000995:Antitubercular Agents