Prognostic value of quantitative analysis of WT1 gene transcripts in adult acute lymphoblastic leukemia.
We quantified Wilm's tumor gene (WT1) using a real time quantitative polymerase chain reaction in 20 adult patients with acute lymphoblastic leukemia at presentation. A WT1 level greater than 906 (median value for the whole series) was a significant predictor of a poor disease-free and overall survival in uni- and multivariate analyses.
Chiusa
Luigi
L
Francia di Celle
Paola
P
Campisi
Paola
P
Ceretto
Cristina
C
Marmont
Filippo
F
Pich
Achille
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics; D011237:Predictive Value of Tests; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D025721:WT1 Proteins / Q000235:genetics*
D012333:RNA, Messenger; D025721:WT1 Proteins