Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.
Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.
Kosowska-Shick
Klaudia
K
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Clark
Catherine
C
Credito
Kim
K
McGhee
Pamela
P
Dewasse
Bonifacio
B
Bogdanovich
Tatiana
T
Appelbaum
Peter C
PC
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D004224:Diterpenes; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D000090822:Ribosomal Protein L3; D012269:Ribosomal Proteins / Q000737:chemistry / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects*; D013297:Streptococcus pyogenes / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004224:Diterpenes; D011500:Protein Synthesis Inhibitors; D000090822:Ribosomal Protein L3; D012269:Ribosomal Proteins; C508887:retapamulin