title: Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors.
abstract: Toll-like receptors (TLRs) are cell-surface signalling molecules that recognize a range of highly conserved pathogen molecules and instigate the appropriate immune response. Here, we report the mapping of all 10 characterized bovine TLR genes using a radiation hybrid panel. The genomic organization of the bovine TLRs is similar to that of humans and mice. TLR1, TLR6 and TLR10 map closely together on Bos taurus chromosome 6 (BTA6), while TLR7 and TLR8 map to the X chromosome. TLR2, TLR3, TLR4, TLR5 and TLR9 map to BTA17, BTA27, BTA8, BTA16 and BTA22 respectively. Our increased knowledge of the genomic organization of the bovine TLR genes may promote our understanding of their evolution and help in the identification of bovine genes underlying disease-resistance traits.
authors.affiliation: Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, Edinburgh EH25 9PS, UK. kirsty.mcguire@bbsrc.ac.uk
authors.forename: K
authors.initials: K
authors.lastname: McGuire
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Werling
authors.forename: J L
authors.initials: JL
authors.lastname: Williams
authors.forename: E J
authors.initials: EJ
authors.lastname: Glass
authors.forename: O
authors.initials: O
authors.lastname: Jann
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D017931:DNA Primers; D021101:Radiation Hybrid Mapping; D051193:Toll-Like Receptors / Q000235:genetics*
chemical_list: D017931:DNA Primers; D051193:Toll-Like Receptors