title: Nephron-sparing surgery in children with primary renal tumor: indications and results.
abstract: Nephron-sparing surgery (NSS) is the treatment of choice for children with bilateral Wilms' tumor (WT), or with WT on a single kidney, or with WT and a disease of the contralateral kidney, or with benign kidney tumor. NSS is a reasonable alternative to nephrectomy in children at risk of metachronous WT, including children with genetic syndromes, children younger than 1 year of age, and children with hyperplastic nephroblastomatosis. The use of NSS in selected children with "low-risk" or stage I "intermediate-risk" WT and a normal contralateral kidney is still controversial. Available data suggest that, in children with WT, NSS does not impair the outcome and has a renal function advantage over nephrectomy.
authors.affiliation: Pediatric Surgery Unit, Policlinico Umberto I, University of Rome "La Sapienza", Rome, Italy. da.cozzi@uniromal.it
authors.forename: Denis Andrew
authors.initials: DA
authors.lastname: Cozzi
authors.forename: Augusto
authors.initials: A
authors.lastname: Zani
mesh_terms: D002648:Child; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D009399:Nephrons; D018579:Patient Selection; D016896:Treatment Outcome; D013520:Urologic Surgical Procedures; D009396:Wilms Tumor / Q000473:pathology / Q000601:surgery*