title: Role of svp in Drosophila pericardial cell growth.
abstract: The Drosophila dorsal vessel is a segmentally repeated linear organ, in which seven-up (svp) is expressed in two pairs of cardioblasts and two pairs of pericardial cells in each segment. Under the control of hedgehog (hh) signaling from the dorsal ectoderm, svp participates in diversifying cardioblast identities within each segment. In this experiment, the homozygous embryos of svp mutants exhibited an increase in cell size of Eve positive pericardial cells (EPCs) and a disarranged expression pattern, while the cardioblasts pattern of svp-lacZ expression was normal. In the meantime, the DAI muscle founders were absent in some segments in svp mutant embryos, and the dorsal somatic muscle patterning was also severely damaged in the late stage mutant embryos, suggesting that svp is required for the differentiation of Eve-positive pericardial cells and DA1 muscle founders and may have a role in EPC cell growth.
authors.affiliation: The Center for Heart Development, the Key Laboratory of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
authors.forename: Wu-Zhou
authors.initials: WZ
authors.lastname: Yuan
authors.forename: Yue-Juan
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Wen-Xian
authors.initials: WX
authors.lastname: Tang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Li
authors.forename: Yue-Qun
authors.initials: YQ
authors.lastname: Wang
authors.forename: Chuan-Bing
authors.initials: CB
authors.lastname: Zhu
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Xiu-Shan
authors.initials: XS
authors.lastname: Wu
authors.forename: Bodmer
authors.initials: B
authors.lastname: Rolf
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004330:Drosophila / Q000166:cytology* / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D006720:Homozygote; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D009132:Muscles / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D009154:Mutation; D032386:Myoblasts, Cardiac / Q000166:cytology / Q000378:metabolism; D010496:Pericardium / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D011987:Receptors, Steroid / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D011987:Receptors, Steroid; D014157:Transcription Factors; C052837:eve protein, Drosophila; C094295:svp protein, Drosophila