title: Fluid preload before spinal anaesthesia in Caesarean section: the effect on neonatal acid-base status.
abstract: OBJECTIVE
  We evaluated the effect of two different preload solutions: (i) Ringer's lactate (compound sodium lactate intravenous infusion BP) and (ii) 0.9% sodium chloride solution on the neonatal acid-base status of the newborn infants. The two standard regimens were compared to detect a possible difference.
  
  
  METHODS
  A 2 L crystalloid fluid bolus was administered immediately before spinal anaesthesia for elective Caesarean section in two groups of 20 healthy parturients, while rigorously maintaining maternal normotension.
  
  
  RESULTS
  No significant differences in the Apgar scores at 1 and 5 min, or infant well-being were demonstrated in either of the two groups. The data show that umbilical artery PCO2 is lower in the Ringer's lactate group and that pH is insignificantly higher by 0.03.
  
  
  CONCLUSIONS
  The choice of Ringer's lactate or saline for fluid preload does not have any effect on neonatal well-being.
authors.affiliation: Assaf Harofeh Medical Center, Department of Anesthesiology, Zerifin, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Chanimov
authors.forename: S
authors.initials: S
authors.lastname: Gershfeld
authors.forename: M L
authors.initials: ML
authors.lastname: Cohen
authors.forename: D
authors.initials: D
authors.lastname: Sherman
authors.forename: M
authors.initials: M
authors.lastname: Bahar
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D002585:Cesarean Section; D000077324:Crystalloid Solutions; D004311:Double-Blind Method; D004809:Ephedrine / Q000008:administration & dosage; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007022:Hypotension / Q000188:drug therapy; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage*; D011247:Pregnancy; D011446:Prospective Studies; D000077325:Ringer's Lactate; D012965:Sodium Chloride / Q000008:administration & dosage; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D014662:Vasoconstrictor Agents; D012965:Sodium Chloride; D004809:Ephedrine