Neonatal eosinophilic pustulosis.
A pre-term, 7-week-old male infant presented with a recurrent pustular eruption involving his face and scalp with associated peripheral blood eosinophilia. Skin biopsy revealed spongiosis with numerous dermal and epidermal eosinophils without predominant follicular involvement. Immunohistology showed deposition of eosinophil granule major basic protein and eosinophil derived neurotoxin in the dermis and epidermis. He responded to conservative management. We discuss the differential diagnosis of neonatal eosinophilic pustular eruptions and suggest the term 'neonatal eosinophilic pustulosis' to best describe our case.
Asgari
Maryam
M
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195-6524, USA.
Leiferman
Kristin M
KM
Piepkorn
Michael
M
Kuechle
Melanie K
MK
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001458:Bandages; D001706:Biopsy; D047093:Eosinophil Major Basic Protein / Q000032:analysis; D047208:Eosinophil-Derived Neurotoxin / Q000032:analysis; D004802:Eosinophilia / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D016712:Mupirocin / Q000627:therapeutic use; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000628:therapy; D012965:Sodium Chloride / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D012965:Sodium Chloride; D016712:Mupirocin; D047208:Eosinophil-Derived Neurotoxin; D047093:Eosinophil Major Basic Protein