Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis.
Platelet Endothelial Cell Adhesion Molecule (PECAM) is an adhesion and signaling molecule used for leukocyte extravasation. We have generated two strains of PECAM-deficient mouse, one in the original C57BL/6 and a second by backcrossing nice generations into the FVB/n strain. The FVB/n strain has reduced responses in models of acute inflammation. We show here that this strain is also susceptible to a chronic pneumonia which leads to pulmonary fibrosis. In contrast, PECAM-deficient C57BL/6 mice do not develop this lung disease and have normal responses in acute models of inflammation. This demonstrates that PECAM-dependent and -independent mechanisms are found in both acute and chronic inflammation. Further, the PECAM-deficient FVB/n strain has many pathologic similarities to the human disease Idiopathic Pulmonary Fibrosis, suggesting that similar molecular mechanisms may play a role in human disease.
Schenkel
Alan R
AR
Department of Microbiology, Immunology and Pathology Colorado State University 1682 Campus Delivery Fort Collins, CO 80523-1682, USA. alan.schenkel@colostate.edu
Chew
Tina W
TW
Chlipala
Elizabeth
E
Harbord
Marcus W N
MW
Muller
William A
WA
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000378:metabolism; D037102:Lectins / Q000032:analysis; D008168:Lung / Q000473:pathology*; D051379:Mice / Q000235:genetics*; D018345:Mice, Knockout; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism*; D011014:Pneumonia / Q000235:genetics* / Q000473:pathology; D001619:beta-N-Acetylhexosaminidases / Q000032:analysis
D037102:Lectins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C429541:Chil3 protein, mouse; D001619:beta-N-Acetylhexosaminidases