title: [Role of visual analysis of first-pass contrast-enhanced MRI in reperfused myocardial infarction].
abstract: The aim of this work is to evaluate the relationship between improvement of regional myocardial function and visual analysis of contrast-enhanced (CE) MRI in patients after acute myocardial infarction. MRI was performed on 19 patients 1 and 11 weeks after a reperfused acute myocardial infarction. Perfusion data (first-pass images [FPI] and delayed CE images) were acquired after an intravenous bolus of gadolinium-DTPA and visually analyzed using a 17 segment model. Each segment was then classified in 3 groups, according to the presence or absence of FPI and CE patterns at baseline study: group 0: normal-appearing segments; group 1: segments with delayed hyper-enhancement but no early hypo-enhancement; group 2: segments with early hypoenhancement. Relative Wall thickening (RWT) was analyzed in each segment and its improvement evaluated in each group. Between first MRI and follow-up study, a significant improvement of RWT occurred in group 1 (mean +/- SD) [from 43.43 +/- 26.59% to 76.71 +/- 47.38%; p = 0.001] but not in group 2 (from 32.73 +/- 25.58% to 39.57 +/- 30.57%; p = NS). In group 0, RWT despite normal value at baseline study exhibited a significant improvement at follow-up (from 65.23 +/- 46.52% to 79.73 +/- 48.46%; p = 0.0015). In conclusion, the combined analysis of early and delayed perfusion abnormalities in MRI in the week following myocardial infarction can predict myocardial viability and allows in the future an evaluation of the efficacy of perfusion therapy.
authors.affiliation: Unité d'IRM, CHU Bocage, bd Mal de Lattre de Tassigny, 21034 Dijon. alexandre.cochet@neuf.fr
authors.forename: A
authors.initials: A
authors.lastname: Cochet
authors.forename: Y
authors.initials: Y
authors.lastname: Cottin
authors.forename: A
authors.initials: A
authors.lastname: Comte
authors.forename: M
authors.initials: M
authors.lastname: Zeller
authors.forename: A
authors.initials: A
authors.lastname: Lalande
authors.forename: C
authors.initials: C
authors.lastname: Touzery
authors.forename: P M
authors.initials: PM
authors.lastname: Walker
authors.forename: S
authors.initials: S
authors.lastname: Voguet
authors.forename: I
authors.initials: I
authors.lastname: L'Huillier
authors.forename: J E
authors.initials: JE
authors.lastname: Wolf
authors.forename: F
authors.initials: F
authors.lastname: Brunotte
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods; D003287:Contrast Media / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology / Q000534:rehabilitation / Q000628:therapy; D015425:Myocardial Reperfusion / Q000534:rehabilitation; D009206:Myocardium / Q000473:pathology*; D020127:Recovery of Function; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA