Certainly can't live without this: SIRT6.
Cellular metabolic rates might regulate aging by impinging on genomic stability through the DNA repair pathways. A new study published in Cell (Mostoslavsky et al., 2006) reports that deficiency in one of the mammalian Sir2 homologs, SIRT6, results in genome instability through the DNA base excision repair pathway and leads to aging-associated degenerative phenotypes.
Rodgers
Joseph T
JT
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Puigserver
Pere
P
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004260:DNA Repair / Q000502:physiology*; D042822:Genomic Instability / Q000502:physiology*; D006655:Histone Deacetylases / Q000378:metabolism; D008136:Longevity; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000378:metabolism; D056565:Sirtuin 2; D037761:Sirtuins / Q000378:metabolism*; D015003:Yeasts
D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; C501860:Sirt6 protein, mouse; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases