Rapid generation of molecular complexity using "hybrid" multi-component reactions (MCRs): application to the synthesis of alpha-amino nitriles and 1,2-diamines.
Methyleneaziridines can be converted into a wide range of 1,2-diamines and 2-cyanopiperidines in a single operation with the formation of three intermolecular carbon-carbon bonds using a "hybrid" MCR.
Shiers
Jason J
JJ
Department of Chemistry, University of Warwick, Gibbert Hill Road, Coventry, UKCV4 7AL.
Clarkson
Guy J
GJ
Shipman
Michael
M
Hayes
Jerome F
JF
D001388:Aziridines / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D003959:Diamines / Q000138:chemical synthesis*; D008697:Methane / Q000031:analogs & derivatives; D008956:Models, Chemical; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*
D001388:Aziridines; D003486:Cyanides; D003959:Diamines; D009570:Nitriles; D010880:Piperidines; D002244:Carbon; D008697:Methane