title: Detection of six copies of the capsulation b locus in a Haemophilus influenzae type b strain isolated from a splenectomized patient with fulminant septic shock.
abstract: We report on the first detection of six copies of the capsulation b locus in a Haemophilus influenzae type b strain isolated from a splenectomized patient with fulminant septic shock associated with disseminated intravascular coagulation and death. The unusual amplification of the locus might have contributed to the rare and severe clinical presentation.
authors.affiliation: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. mcerquet@iss.it
authors.forename: Marina
authors.initials: M
authors.lastname: Cerquetti
authors.forename: Rita
authors.initials: R
authors.lastname: Cardines
authors.forename: Maria
authors.initials: M
authors.lastname: Giufrè
authors.forename: Annalisa
authors.initials: A
authors.lastname: Castella
authors.forename: Monica
authors.initials: M
authors.lastname: Rebora
authors.forename: Paola
authors.initials: P
authors.lastname: Mastrantonio
authors.forename: Marta Luisa
authors.initials: ML
authors.lastname: Ciofi Degli Atti
mesh_terms: D000328:Adult; D016667:Bacterial Capsules / Q000235:genetics*; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D018628:Gene Dosage; D005798:Genes, Bacterial; D006192:Haemophilus Infections / Q000150:complications / Q000382:microbiology* / Q000601:surgery; D019741:Haemophilus influenzae type b / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D012772:Shock, Septic / Q000382:microbiology*; D013156:Splenectomy