title: Glucose-insulin-potassium infusion in acute myocardial infarction: a hemodynamic study.
abstract: BACKGROUND
  In this study, we investigated whether adjunction of glucose-insulin-potassium (GIK) infusion to primary percutaneous coronary intervention (PCI) affects hemodynamics in patients with an acute myocardial infarction.
  
  
  METHODS
  Hemodynamic measurements were performed in a subset of patients (n = 81) in the GIPS 2, starting immediately after PCI and continued for 12 hours.
  
  
  RESULTS
  Cardiac index values were stable in both groups. During the first measurements, diastolic pulmonary artery pressure and the pulmonary capillary wedge pressure (PCWP) were significantly higher in the non-GIK group (diastolic pulmonary artery pressure 15 +/- 5 vs 18 +/- 7 mm Hg, P = .028 and PCWP 14 +/- 6 vs 18 +/- 7 mm Hg, P = .030). There was a decrease in PCWP from 18 +/- 7 to 15 +/- 6 mm Hg in the non-GIK group during the first 6 hours, whereas the pressures remained at 14 +/- 6 mm Hg in the GIK group. This difference in pattern of change did not reach statistical significance in the analysis of the interaction of PCWP by GIK group (P = .065).
  
  
  CONCLUSIONS
  Glucose-insulin-potassium infusion as adjunctive therapy to PCI in patients with acute myocardial infarction, without overt signs of heart failure, did not negatively affect hemodynamics.
authors.affiliation: Department of Cardiology, Thorax Center, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Arend
authors.initials: A
authors.lastname: Bergstra
authors.forename: Tone
authors.initials: T
authors.lastname: Svilaas
authors.forename: Ad F M
authors.initials: AF
authors.lastname: van den Heuvel
authors.forename: Iwan C C
authors.initials: IC
authors.lastname: van der Horst
authors.forename: Felix
authors.initials: F
authors.lastname: Zijlstra
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001786:Blood Glucose / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000379:methods; D011189:Potassium Chloride / Q000008:administration & dosage*; D013223:Statistics as Topic
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011189:Potassium Chloride; D005947:Glucose