Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi.
Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.
Han
Quan-Bin
QB
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine.
Wang
Yu-Lin
YL
Yang
Ling
L
Tso
Ting-Fai
TF
Qiao
Chun-Feng
CF
Song
Jing-Zheng
JZ
Xu
Li-Jia
LJ
Chen
Shi-Lin
SL
Yang
Da-Jian
DJ
Xu
Hong-Xi
HX
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D017368:Protein Prenylation; D012116:Resins, Plant / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D012116:Resins, Plant; D044004:Xanthones