title: Study on the compounds containing 19F and 10B atoms in a single molecule for the application to MRI and BNCT.
abstract: Magnetic resonance imaging (MRI) and boron-neutron capture therapy (BNCT) are quite attractive techniques for diagnosis and treatment of cancer, respectively. In order to progress the study on both MRI and BNCT, the novel compounds containing 19F and 10B atoms in a single molecule were designed and synthesized. In the present paper, the syntheses and the internalization rates into tumor cells of these compounds are elucidated.
authors.affiliation: Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hattori
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Asano
authors.forename: Yoko
authors.initials: Y
authors.lastname: Niki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kondoh
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Tateaki
authors.initials: T
authors.lastname: Wakamiya
mesh_terms: D000818:Animals; D001895:Boron / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy / Q000379:methods; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D005461:Fluorine / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007554:Isotopes; D008279:Magnetic Resonance Imaging / Q000379:methods; D015394:Molecular Structure; D009369:Neoplasms / Q000737:chemistry / Q000378:metabolism*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats
chemical_list: D001897:Boronic Acids; D003287:Contrast Media; D007554:Isotopes; C512275:beta-(4-borono-2,6-difluorophenyl)alanine; C512276:beta-(4-borono-2,6-difluorophenyl)alaninol; D005461:Fluorine; D010649:Phenylalanine; D001895:Boron