Mitosin/CENP-F in mitosis, transcriptional control, and differentiation.
Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.
Ma
Li
L
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhao
Xiangshan
X
Zhu
Xueliang
X
D002454:Cell Differentiation; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D006801:Humans; D008840:Microfilament Proteins; D008938:Mitosis; D032342:Muscle Cells / Q000166:cytology; D014158:Transcription, Genetic
D002868:Chromosomal Proteins, Non-Histone; D008840:Microfilament Proteins; C094772:centromere protein F