title: Osmotic stress responses of Streptococcus mutans UA159.
abstract: The hyperosmotic stress response of Streptococcus mutans was investigated. Real-time reverse transcriptase-PCR and slot-blot analysis revealed that opuAA, opcA, Smu.2115, sodA and nox were induced after exposure to 0.4 M NaCl. Our data suggest that there is a cross-talk between osmotic and oxidative stress responses in S. mutans. Inactivation of Smu.2115, encoding a putative oxidoreductase, resulted in an acid-resistant and hydrogen peroxide-sensitive phenotype.
authors.affiliation: Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Abranches
authors.forename: José A
authors.initials: JA
authors.lastname: Lemos
authors.forename: Robert A
authors.initials: RA
authors.lastname: Burne
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D018869:Heat-Shock Response; D006801:Humans; D009997:Osmotic Pressure; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012965:Sodium Chloride / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000235:genetics / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; D012965:Sodium Chloride; D010088:Oxidoreductases