title: Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model.
abstract: Administration of different doses of the diphenol resveratrol had no effect on the growth of an intramuscularly implanted experimental tumour, the Lewis lung carcinoma. These results do not agree with previous reports where a clear effect of resveratrol was shown on tumour burden in both mice and rats. However, administration of the diphenol had a clear anti-metastatic effect, decreasing both the number and the weight of the lung metastases. Similar effects were observed both at 5 and 25mg/kg body weight per day, resulting in an approximately 40% reduction in the number of metastases. These results suggest that resveratrol could be tentatively given as a preventive agent in cancer patients undergoing radiotherapy or chemotherapy.
authors.affiliation: Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Busquets
authors.forename: Elisabet
authors.initials: E
authors.lastname: Ametller
authors.forename: Gemma
authors.initials: G
authors.lastname: Fuster
authors.forename: Mireia
authors.initials: M
authors.lastname: Olivan
authors.forename: Viktoria
authors.initials: V
authors.lastname: Raab
authors.forename: Josep M
authors.initials: JM
authors.lastname: Argilés
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: López-Soriano
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D018827:Carcinoma, Lewis Lung / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control*; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D000077185:Resveratrol