title: Ductal carcinoma in situ with microinvasion: clinicopathologic study and biopathologic profile.
abstract: Data regarding the biologic behavior and surgical management, in particular the axillary lymph node excision, of ductal carcinoma in situ with microinvasion (DCIS-MI) are controversial. Therefore, we decided to study the histopathologic characteristics, the biopathologic profile, as well as the follow-up of a group of patients with DCIS-MI. Thirty-one cases of DCIS-MI, 21 of whom were treated with axillary lymph node dissection, were studied. All cases were classified according to the Van Nuys classification, and the extension of DCIS was quantified. The biopathologic profile (ER, PR, MIB 1, p53, c-erbB-2) as well as the follow-up was also investigated. The results did not reveal any statistically significant differences between the two groups, and there was no statistically significant relationship between the extension of DCIS and the number of microinvasion (MI) foci or maximum MI diameter, or between Van Nuys classification of DCIS and again the number of MI foci or maximum MI diameter. DCIS-MI seems associated with good prognosis. None of the patients had relapses or metastases. Our data seem to suggest that the natural history of DCIS-MI resembles DCIS, and we, therefore, suggest that all the surgically removed area should be examined histologically to avoid missing foci of infiltrating breast cancer larger than 1mm.
authors.affiliation: Institute of Pathological Anatomy and Histology, Division of Cancer Research, Perugia University, Policlinico Monteluce, Box 1454, Perugia I-06122, Italy. antonio.cavaliere@infinito.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Cavaliere
authors.forename: Massimo
authors.initials: M
authors.lastname: Scheibel
authors.forename: Guido
authors.initials: G
authors.lastname: Bellezza
authors.forename: Renato
authors.initials: R
authors.lastname: Colella
authors.forename: Rino
authors.initials: R
authors.lastname: Vitali
authors.forename: Stefania
authors.initials: S
authors.lastname: Gori
authors.forename: Cyntia
authors.initials: C
authors.lastname: Aristei
authors.forename: Antonio
authors.initials: A
authors.lastname: Rulli
authors.forename: Angelo
authors.initials: A
authors.lastname: Sidoni
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015996:Survival Rate