Piracetam--an old drug with novel properties?
Piracetam (2-oxo-1-pyrrolidine-acetamide), the most common of the nootropic drugs, is a cyclic derivative of gamma-aminobutyric acid. The treatment with piracetam improves learning, memory, brain metabolism, and capacity. Piracetam has been shown to alter the physical properties of the plasma membrane by increasing its fluidity and by protecting the cell against hypoxia. It increases red cell deformability and normalizes aggregation of hyperactive platelets. Piracetam is an agent with antithrombotic, neuroprotective and rheological properties. The interaction of this molecule with the membrane phospholipids restores membrane fluidity and could explain the efficacy of piracetam in various disorders ranging from dementia and vertigo to myoclonus and stroke.
Winnicka
Katarzyna
K
Department of Drug Technology, Medical University of Białystok, 1 Kilińskiego Str., 15-089 Białystok, Poland.
Tomasiak
Marian
M
Bielawska
Anna
A
D000544:Alzheimer Disease / Q000188:drug therapy; D001037:Aphasia / Q000188:drug therapy; D001792:Blood Platelets / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D006801:Humans; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010889:Piracetam / Q000494:pharmacology* / Q000627:therapeutic use; D020521:Stroke / Q000188:drug therapy
D018697:Nootropic Agents; D010889:Piracetam