A porphyrin increases survival time of mice after intracerebral prion infection.
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
Kocisko
David A
DA
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA. DKocisko@niaid.nih.gov
Caughey
Winslow S
WS
Race
Richard E
RE
Roper
Grant
G
Caughey
Byron
B
Morrey
John D
JD
D000818:Animals; D001812:Blood-Brain Barrier; D051379:Mice; D008822:Mice, Transgenic; D011166:Porphyrins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017096:Prion Diseases / Q000188:drug therapy*
D011166:Porphyrins; C016136:tetraphenylporphine sulfonate