title: In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains.
abstract: The antimicrobial activity of human beta-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.
authors.affiliation: Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy.
authors.forename: Giuseppantonio
authors.initials: G
authors.lastname: Maisetta
authors.forename: Giovanna
authors.initials: G
authors.lastname: Batoni
authors.forename: Semih
authors.initials: S
authors.lastname: Esin
authors.forename: Walter
authors.initials: W
authors.lastname: Florio
authors.forename: Daria
authors.initials: D
authors.lastname: Bottai
authors.forename: Flavia
authors.initials: F
authors.lastname: Favilli
authors.forename: Mario
authors.initials: M
authors.lastname: Campa
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D003428:Cross Infection / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D044967:Serum / Q000502:physiology; D023083:beta-Defensins / Q000494:pharmacology*
chemical_list: C422950:DEFB103A protein, human; D023083:beta-Defensins