title: Optimization of pulsed wave tissue Doppler to predict left ventricular reverse remodeling after cardiac resynchronization therapy.
abstract: OBJECTIVE
  The optimal use of pulsed wave Doppler tissue imaging (DTI) in predicting left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT) was investigated.
  
  
  METHODS
  DTI was performed in 69 patients before and 3 months after CRT. Echocardiographic reverse remodeling was observed in 38 patients. LV dyssynchrony was measured with the time to onset or peak systolic velocity in 2- and 6-basal segment models.
  
  
  RESULTS
  The time to onset and either the standard deviation of 6 segments of > 20 ms or a delay of > or = 60 ms between any 2 of 6 segments had a similar predictive accuracy (sensitivity, 97% and 95%, respectively; specificity, 74% and 73%, respectively). The time to peak systolic velocity or evaluating 2 segments was less accurate.
  
  
  CONCLUSIONS
  Evaluation of 6 segments is necessary to predict LV reverse remodeling after CRT. The time to onset of systolic velocity is superior to the time to peak velocity.
authors.affiliation: Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands. annemieke.jansen@cze.nl
authors.forename: Annemieke H M
authors.initials: AH
authors.lastname: Jansen
authors.forename: Frank
authors.initials: F
authors.lastname: Bracke
authors.forename: Jan M
authors.initials: JM
authors.lastname: van Dantzig
authors.forename: Albert
authors.initials: A
authors.lastname: Meijer
authors.forename: Erik H M
authors.initials: EH
authors.lastname: Korsten
authors.forename: Kathinka H
authors.initials: KH
authors.lastname: Peels
authors.forename: Norbert M
authors.initials: NM
authors.lastname: van Hemel
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000628:therapy*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D020257:Ventricular Remodeling