Study on the compounds containing 19F and 10B atoms in a single molecule for the application to MRI and BNCT.
Magnetic resonance imaging (MRI) and boron-neutron capture therapy (BNCT) are quite attractive techniques for diagnosis and treatment of cancer, respectively. In order to progress the study on both MRI and BNCT, the novel compounds containing 19F and 10B atoms in a single molecule were designed and synthesized. In the present paper, the syntheses and the internalization rates into tumor cells of these compounds are elucidated.
Hattori
Yoshihide
Y
Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
Asano
Tomoyuki
T
Niki
Yoko
Y
Kondoh
Hirofumi
H
Kirihata
Mitsunori
M
Yamaguchi
Yoshihiro
Y
Wakamiya
Tateaki
T
D000818:Animals; D001895:Boron / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy / Q000379:methods; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D005461:Fluorine / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007554:Isotopes; D008279:Magnetic Resonance Imaging / Q000379:methods; D015394:Molecular Structure; D009369:Neoplasms / Q000737:chemistry / Q000378:metabolism*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats
D001897:Boronic Acids; D003287:Contrast Media; D007554:Isotopes; C512275:beta-(4-borono-2,6-difluorophenyl)alanine; C512276:beta-(4-borono-2,6-difluorophenyl)alaninol; D005461:Fluorine; D010649:Phenylalanine; D001895:Boron