title: Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.
abstract: The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
authors.affiliation: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812, Japan. fujita@kokyu.med.kyushu-u.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujita
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ouchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Harada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Inoshima
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kuwano
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakanishi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000633:toxicity*; D004318:Doxycycline / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D001761:Bleomycin; D004318:Doxycycline