title: Modular multidentate phosphine ligands: application to palladium-catalyzed allylic alkylations.
abstract: Multidentate phosphines were readily obtained by reaction of chiral multidentate amines, prepared via ring opening of (S)-N-tosyl-2-isopropylaziridine with ammonia, primary, and secondary amines, with achiral phosphorus containing building blocks. The phosphines were used in palladium-catalyzed alkylation of rac-3-cyclohexenyl and cyclopentenyl carbonates. The enantioselectivity and reactivity were largely dependent on the structure of the amine core of the ligands. Up to 88% ee was observed in reactions with the six-membered substrate.
authors.affiliation: Department of Chemistry, Organic Chemistry, Royal Institute of Technology, SE 100 44, Stockholm, Sweden.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Pei
authors.forename: Emilie
authors.initials: E
authors.lastname: Brulé
authors.forename: Christina
authors.initials: C
authors.lastname: Moberg