Ribose-modified mizoribine analogues: synthesis and biological evaluation.
Synthesis, conformational analysis and antitumor evaluation of 2'- and 3'-C-methyl analogues of mizoribine (bredinine, 4-carbamoyl-1-beta-D-ribofuranosylimidazole-5-olate) are reported.
Franchetti
Palmarisa
P
Dipartimento di Scienze Chimiche, Universitá di Camerino, Italy.
Pasqualini
Michela
M
Cappellacci
Loredana
L
Petrelli
Riccardo
R
Vita
Patrizia
P
Grifantini
Mario
M
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D020014:K562 Cells; D015394:Molecular Structure; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D004791:Enzyme Inhibitors; D012263:Ribonucleosides; C010052:mizoribine; D007168:IMP Dehydrogenase