title: Identification of genes involved in alcohol consumption and cigarettes smoking.
abstract: We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis using the Collaborative Study on the Genetics of Alcoholism data. We analyzed 115 extended non-Hispanic White families and tested for linkage using two phenotypes: the maximum number of drinks in a 24-hour period and the number of packs smoked per day for one year. Our results showed that the linkage signal increased using single-nucleotide polymorphisms compared with microsatellite markers and that the screening test gave similar results to that of the bivariate analysis, suggesting its potential use in reducing overall analysis time.
authors.affiliation: Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA. mandrade@mayo.edu
authors.forename: Mariza
authors.initials: M
authors.lastname: de Andrade
authors.forename: Curtis L
authors.initials: CL
authors.lastname: Olswold
authors.forename: Joshua P
authors.initials: JP
authors.lastname: Slusser
authors.forename: Larry A
authors.initials: LA
authors.lastname: Tordsen
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Atkinson
authors.forename: Kari G
authors.initials: KG
authors.lastname: Rabe
authors.forename: Susan L
authors.initials: SL
authors.lastname: Slager
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012907:Smoking / Q000235:genetics*