title: Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors.
abstract: The number of people with diabetes is expected to rise from the current estimated 150 million to 220 million in 2010 and 300 million in 2025, and 90% is Type 2 diabetes or non-insulin dependent diabetes mellitus (NIDDM). Voglibose, one of the most important alpha-glucosidase inhibitors, delays the digestion and absorption of carbohydrates, thereby inhibiting postprandial hyperglycemia and hyperinsulinemia, and is the aid in the treatment of diabetes. In this paper, properties and the preparation of voglibose are reviewed.
authors.affiliation: Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, PR China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Chen
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yinchu
authors.initials: Y
authors.lastname: Shen
mesh_terms: D001671:Biochemistry / Q000379:methods; D002240:Carbohydrate Sequence; D003511:Cyclohexanols / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008969:Molecular Sequence Data; D050111:Imino Sugars
chemical_list: D003511:Cyclohexanols; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007294:Inositol; C054577:AO 128; C043270:valiolamine; D050111:Imino Sugars; C102817:voglibose