title: Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome.
abstract: To establish whether angiotensin-converting enzyme 2 (ACE2) gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome. The study was conducted in 353 patients with metabolic syndrome. The alleles of the ACE2 A/G polymorphism, which is located on the X chromosome, were detected using polymerase chain reaction and subsequent cleavage by Alu I restriction endonuclease. G allele frequencies in patients with metabolic syndrome were 36.6% in female subjects and 43.4% in male subjects, respectively. Female patients with metabolic syndrome who carry the GG genotype had a significantly higher diastolic blood pressure compared with other genotypes. Multivariate logistic regression showed that female gender (P = 0.019) and carrying only the G allele (odds ratio 2.83 [95% CI 1.36 to 5.91]; P = 0.005) were significantly associated with increased diastolic blood pressure. It is concluded that the ACE2 A/G polymorphism is associated with hypertension in patients with metabolic syndrome.
authors.affiliation: Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhong
authors.forename: Zhengchen
authors.initials: Z
authors.lastname: Yan
authors.forename: Daoyan
authors.initials: D
authors.lastname: Liu
authors.forename: Yinxing
authors.initials: Y
authors.lastname: Ni
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhao
authors.forename: Shanjun
authors.initials: S
authors.lastname: Zhu
authors.forename: Martin
authors.initials: M
authors.lastname: Tepel
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000085962:Angiotensin-Converting Enzyme 2; D044466:Asian People / Q000235:genetics; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000208:ethnology* / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2