Stereoselective synthesis of the western hemisphere of salinomycin.
[structure: see text]. A convergent and module-based strategy for the asymmetric synthesis of the western hemisphere (C1-C17 fragment) of salinomycin has been devised. This new synthetic approach relies on highly stereoselective C-glycosidation and aldol processes.
Larrosa
Igor
I
Departament de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain.
Romea
Pedro
P
Urpí
Fèlix
F
D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007476:Ionophores; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D000095662:Polyether Polyketides
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D007476:Ionophores; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides; C116609:3-hydroxybutanal