Gammadelta T cells: an alternative type of professional APC.
A subtype of activated human gammadelta T cells, termed Vdelta2+ T cells, has antigen-presentation features similar in potency and efficacy to those seen in dendritic cells. Comparable treatment of alphabeta T cells does not result in 'professional' antigen presenting cells (APCs). What is so special about Vdelta2+ T cells? How do they acquire these unexpected properties? Under what physiological conditions would such a bridge between innate and adaptive immunity come into play? In addition to discussing these questions, we introduce a model that correlates the expression of lymph node homing receptors in Vdelta2+ T cells with the involvement of this alternative type of APC in anti-microbial alphabeta T cell responses.
Moser
Bernhard
B
Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland. bernhard.moser@izb.unibe.ch
Brandes
Marlène
M
D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D018925:Chemokines / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D018925:Chemokines; D016692:Receptors, Antigen, T-Cell, gamma-delta