title: A bioactive sol-gel glass implant for in vivo gentamicin release. Experimental model in Rabbit.
abstract: Biomaterial pieces with osteogenic properties, suitable for use in the treatment of bone defects, were synthesized. The materials, which avoid bone infections, are exclusively composed of gentamicin sulfate and bioactive SiO2-CaO-P2O5 sol-gel glass (synthesized previously), and were manufactured by means of uniaxial and isostatic pressure of the mixed components. After implanting the pieces into rabbit femur, we studied (1) antibiotic release, determining the concentration in proximal and distal bone, liver, kidney, and lung as a function of time, and (2) bone growth as a consequence of the glass reactivity in the biological environment. The results demonstrated that the implants are good carriers for local gentamicin release into the local osseous tissue, where they show excellent biocompatibility and bone integration. Moreover, these implants are able to promote bone growth during the resorption process.
authors.affiliation: Laboratorio de Cirugía Ortopédica Experimental, Facultad de Medicina, Universidad de Murcia, Spain. meseguer@arrakis.es
authors.forename: L
authors.initials: L
authors.lastname: Meseguer-Olmo
authors.forename: Mj
authors.initials: M
authors.lastname: Ros-Nicolás
authors.forename: V
authors.initials: V
authors.lastname: Vicente-Ortega
authors.forename: M
authors.initials: M
authors.lastname: Alcaraz-Baños
authors.forename: M
authors.initials: M
authors.lastname: Clavel-Sainz
authors.forename: D
authors.initials: D
authors.lastname: Arcos
authors.forename: C V
authors.initials: CV
authors.lastname: Ragel
authors.forename: M
authors.initials: M
authors.lastname: Vallet-Regí
authors.forename: Cl
authors.initials: C
authors.lastname: Meseguer-Ortiz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D004337:Drug Carriers; D005260:Female; D005269:Femur / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D005782:Gels; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005898:Glass; D008297:Male; D023421:Models, Animal; D019637:Orthopedic Procedures / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology; D010316:Particle Size; D011817:Rabbits; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D005782:Gels; D005839:Gentamicins