A convenient TLC method for the identification of local anesthetics.
A TLC method for the separation of seven local anesthetics and the related antiarrhythmic drug procainamide was developed. Spraying the plates with cobalt(II) thiocyanate solution, followed by spraying with Ehrlich's reagent allowed a clear distinction between the drugs, except for the couple articaine/prilocaine. Articaine could be distinguishedfrom prilocaine and other local anesthetics by a colour reaction with copper(II) sulphate solution.
Schmidt
M
M
Department Pharmazie--Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Germany.
Bracher
F
F
D000779:Anesthetics, Local / Q000032:analysis* / Q000302:isolation & purification; D001547:Benzaldehydes; D002355:Carticaine / Q000032:analysis / Q000302:isolation & purification; D002855:Chromatography, Thin Layer; D003035:Cobalt; D003116:Color; D007202:Indicators and Reagents; D007510:Isatin / Q000737:chemistry; D011318:Prilocaine / Q000032:analysis / Q000302:isolation & purification; D013861:Thiocyanates
D000779:Anesthetics, Local; D001547:Benzaldehydes; D007202:Indicators and Reagents; D013861:Thiocyanates; D011318:Prilocaine; C038956:cobalt thiocyanate; D003035:Cobalt; D007510:Isatin; D002355:Carticaine; C510241:p-dimethylaminobenzaldehyde