title: Epileptogenesis and rational therapeutic strategies.
abstract: The understanding of neurobiological mechanisms of epileptogenesis is essential for rational approaches for a possible disease modification as well as treatment of underlying causes of the epilepsies. More effort is necessary to translate results from basic investigations into new approaches for clinical research and to better understand a relationship with findings from clinical studies. The following report is a condensed synapsis in which molecular mechanisms of epileptogenesis, pharmacological modulation of epileptogenesis, evidence based therapy, refractoriness and prediction of outcome is provided in order to stimulate further collaborative international research.
authors.affiliation: Epilepsy Centre - Neurological Clinic, University Erlangen-Nuernberg, Erlangen, Germany. herman.stefan@neuro.imed.uni-erlangen.de
authors.forename: H
authors.initials: H
authors.lastname: Stefan
authors.forename: F H
authors.initials: FH
authors.lastname: Lopes da Silva
authors.forename: W
authors.initials: W
authors.lastname: Löscher
authors.forename: D
authors.initials: D
authors.lastname: Schmidt
authors.forename: E
authors.initials: E
authors.lastname: Perucca
authors.forename: M J
authors.initials: MJ
authors.lastname: Brodie
authors.forename: P A J M
authors.initials: PA
authors.lastname: Boon
authors.forename: W H
authors.initials: WH
authors.lastname: Theodore
authors.forename: S L
authors.initials: SL
authors.lastname: Moshé
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D023902:Chromosome Pairing / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology*; D019317:Evidence-Based Medicine; D006801:Humans; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants