title: Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates.
abstract: Two novel axially substituted phthalocyanines, namely bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon (IV) (1) and its N-methylated derivative 2, have been synthesized. The dicationic phthalocyanine 2 is non-aggregated in water and exhibits good photophysical properties. The non-covalent BSA conjugates of these compounds have also been prepared. Compound 2 and the conjugate 2-BSA show extremely high photodynamic activities toward B16 melanoma cancer cell lines. The corresponding 50% growth-inhibitory (IC50) ratios are 33 and 38 nM, respectively.
authors.affiliation: College of Chemistry and Chemical Engineering, Institute of Research on Functional Materials, Fuzhou University, Fuzhou 350002, China.
authors.forename: Xiong-Jie
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Huang
authors.forename: Yu-Jiao
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Fen-Xiang
authors.initials: FX
authors.lastname: Tang
authors.forename: Dennis K P
authors.initials: DK
authors.lastname: Ng
authors.forename: Jian-Cheng
authors.initials: JC
authors.lastname: Sun
mesh_terms: D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D017646:Organosilicon Compounds; D017319:Photosensitizing Agents; C511135:bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon; C082854:silicon phthalocyanine; D012710:Serum Albumin, Bovine