title: Family-based association studies of the TCP1 gene and schizophrenia in the Chinese Han population.
abstract: A previous case-control study by Yang et al. indicated that the TCP1 gene in 6q25 was associated with schizophrenia in the Han population. To replicate this result, we selected eight SNPs (rs2273828, rs3818298, rs1547094, rs1547093, rs2295898, rs2295899, rs4832, rs15982) spanning the whole gene and performed a family-based study using 325 trios samples. Our transmission disequilibrium test showed neither allele nor haplotype association with schizophrenia, and suggests that the TCP1 locus is not associated with schizophrenia in the Chinese population. Since 6q25 has consistently been found to be a susceptible region for schizophrenia, we suggest that other genes within this region should be the focus of attention.
authors.affiliation: Bio-X Center, Shanghai Jiao Tong University, Shanghai, P.R. China.
authors.forename: W
authors.initials: W
authors.lastname: Tang
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.forename: G
authors.initials: G
authors.lastname: Feng
authors.forename: L
authors.initials: L
authors.lastname: Yan
authors.forename: Y
authors.initials: Y
authors.lastname: Xing
authors.forename: S
authors.initials: S
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.forename: R
authors.initials: R
authors.lastname: Tang
authors.forename: J
authors.initials: J
authors.lastname: Du
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: He
authors.forename: P
authors.initials: P
authors.lastname: Liang
authors.forename: L
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C533304:TCP1 protein, human; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins