title: Clinical and prognostic role of plasma coagulation factor XIII activity for bleeding disorders and 6-year survival in patients with chronic liver disease.
abstract: OBJECTIVE
  Alterations of plasma coagulation factor XIII may contribute to bleeding disorders in patients with liver cirrhosis. As standard clotting tests such as prothrombin time or activated thromboplastin time (aPTT) cannot detect factor XIII deficiency, this may often be overlooked in clinical practice. We aimed to define factor XIII's clinical and prognostic role in chronic liver disease.
  
  
  METHODS
  Factor XIII activities were assessed among various other parameters in 111 patients with chronic liver diseases during evaluation for liver transplantation in a prospective study.
  
  
  RESULTS
  Unlike coagulation factors II, V or VII, factor XIII activity was maintained in the majority of patients with liver cirrhosis. However, although rarely, factor XIII deficiencies (<50%) occurred, especially in Child C cirrhosis. Factor XIII levels correlated with liver's biosynthetic capacity (cholinesterase activity, albumin, total protein) as well as with platelet count, global coagulation tests and other single coagulation factors. Patients reporting a current systemic bleeding tendency at study entry had significantly reduced factor XIII. In a 6-year follow-up, patients with factor XIII<50% had a significantly increased risk of severe upper gastrointestinal bleed, and reduced factor XIII (<50%, 50-75% vs. normal) was associated with increased mortality.
  
  
  CONCLUSIONS
  Factor XIII deficiency is rare in patients with liver cirrhosis, but is associated with a clinical bleeding tendency and an unfavorable prognosis for future hemorrhages and survival.
authors.affiliation: Department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Tacke
authors.forename: Kai
authors.initials: K
authors.lastname: Fiedler
authors.forename: Mario
authors.initials: M
authors.lastname: von Depka
authors.forename: Tom
authors.initials: T
authors.lastname: Luedde
authors.forename: Hartmut
authors.initials: H
authors.lastname: Hecker
authors.forename: Michael P
authors.initials: MP
authors.lastname: Manns
authors.forename: Arnold
authors.initials: A
authors.lastname: Ganser
authors.forename: Christian
authors.initials: C
authors.lastname: Trautwein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D002908:Chronic Disease; D005176:Factor XIII / Q000378:metabolism*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011517:Prothrombin Time / Q000145:classification; D015996:Survival Rate
chemical_list: D005176:Factor XIII