Pattern of prolactin secretion after administration of gonadotropin-releasing hormone agonist at the preovulatory phase of intrauterine insemination cycles.
OBJECTIVE
Administration of a gonadotropin-releasing hormone (GnRH) agonist at the preovulatory phase is an option for triggering ovulation in assisted reproductive technology cycles. The aim of this work was to investigate the pattern of prolactin secretion after the administration of a single dose of GnRH-agonist at the preovulatory phase.


METHODS
Descriptive study at a tertiary referral center.


METHODS
Fifteen normally ovulating patients undergoing ovarian stimulation for intrauterine insemination were studied.


METHODS
Ovarian stimulation was carried out using human menopausal gonadotropin (intramuscular 75 IU daily). When at least one follicle reached 17 mm (observed echographically), 0.5 mg of buserelin acetate was administered. Blood samples were taken to determine prolactin concentrations, at the time of agonist injection and 4, 8, 12, 24 and 48 hours later.


RESULTS
A statistically significant increase in serum levels of prolactin was observed 4, 8 and 12 hours after GnRH-agonist administration, with a peak at 8 hours.


CONCLUSIONS
The administration of a single dose of GnRH-agonist at the preovulatory phase in patients undergoing ovarian stimulation performed with human menopausal gonadotropin causes a significant increase in serum prolactin levels.
Cavagna
Mario
M
Human Reproduction Division, Hospital Pérola Byington, Rua Viradouro 58, CEP 04538-110 São Paulo, SP, Brazil. cavagna@hotmail.com
Mantese
João Carlos
JC
Freitas
Gilberto da Costa
Gda C
Dzik
Artur
A
Soares
Jonathas Borges
JB
Hameiry
Yaron
Y
Izzo
Vicente Mario
VM
Pinotti
José Aristodemo
JA
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000819:agonists / Q000031:analogs & derivatives; D006801:Humans; D008593:Menopause; D006080:Ovarian Follicle / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin