title: Physical rehabilitation of stroke patients and redox alterations.
abstract: We studied 43 acute stroke patients: 22 patients were randomly assigned to the experimental group and 21 patients - to the control group. Experimental group patients underwent neuro-muscular electric stimulation (NMES) in addition to standard rehabilitation regimen. Pro- and antioxidant activity was evaluated at admission and at the end of acute stage: paramagnetic centers of blood (ceruloplasmin, Fe(3+) transferrin, Mn(2+), Fe(2+), MetHb, NO, HbNO, FeSNO) were investigated by EPR-spectroscopy. We observed excessive formation of promoters of free-radical oxidation and inactivation of antioxidative protection system. Concentration of free NO was decreased in majority of the patients. Following NMES application, we observed normalization of almost every parameter of redox system: inactivation of Fe(3+) and Mn(2+) ions, increase of total concentration of ceruloplasmin and decrease of its oxidation degree, increase of Fe(3+) transferrin level, decrease of MetHb concentration, normalization of free NO. These alterations were more prominent compared to the control group patient (p<0,05). We conclude, that NMES facilitates restoration of the balance between pro- and antioxidative systems and decreases intensity of oxidative stress.
authors.affiliation: Department of Medical Rehabilitation and Sports Medicine, Tbilisi State Medical University.
authors.forename: E
authors.initials: E
authors.lastname: Tataradze
authors.forename: N
authors.initials: N
authors.lastname: Chabashvili
authors.forename: T
authors.initials: T
authors.lastname: Sanikidze
mesh_terms: D000368:Aged; D004558:Electric Stimulation / Q000379:methods; D015444:Exercise; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction; D010291:Paresis / Q000209:etiology / Q000378:metabolism / Q000534:rehabilitation*; D026741:Physical Therapy Modalities; D020521:Stroke / Q000150:complications / Q000378:metabolism; D000071939:Stroke Rehabilitation
chemical_list: D009569:Nitric Oxide