[OPUS: a randomised multicenter trial of integrated versus standard treatment for patients with a first-episode psychosis--secondary publication].
A total of 547 patients with first-episode psychosis were included in a randomised clinical trial comparing integrated treatment with standard treatment. The integrated treatment consisted of assertive community treatment with programmes for family involvement and social skills training. Patients in integrated treatment had significantly fewer psychotic and negative symptoms, less comorbid substance abuse, better adherence to treatment and more satisfaction with treatment at one-year and two-year follow-ups.
Nordentoft
Merete
M
H:S Bispebjerg Hospital, Psykiatrisk Afdeling, København NV. merete.nordentoft@dadlnet.dk
Petersen
Lone
L
Jeppesen
Pia
P
Thorup
Anne A Elgaard
AA
Abel
Maj-Britt Helle
MB
Ohlenschlaeger
Johan
J
Christensen
Torben Østergaard
TØ
Krarup
Gertrud
G
Jørgensen
Per
P
D000293:Adolescent; D000328:Adult; D003156:Community Mental Health Services; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000628:therapy*; D012559:Schizophrenia / Q000628:therapy*; D012944:Social Support; D016896:Treatment Outcome