title: Intractable otitis media with eosinophils: Importance of diagnosis and validity of treatment for hearing preservation.
abstract: This study investigated hearing levels in cases of intractable otitis media with eosinophils and validated the treatment strategy. Medical charts were reviewed retrospectively. The diagnosis was made when the proportion of eosinophils in middle ear secretions exceeded 10%. Twelve patients were identified and treated with an antihistaminergic agent, leukotriene receptor antagonist and topical steroid. The air-bone conductance gap decreased significantly with the relief of subjective symptoms. Bone conduction hearing levels at 4 and 8 kHz were higher than at lower frequencies. There was a significant correlation between subjective symptom duration and bone conduction hearing level at 8 kHz, which diminished with treatment. Compared with suppurative otitis, active otitis with eosinophilia damages high-tone sensory hearing in a time-dependent manner, and antiallergic treatment prevents progression of the high-tone sensory hearing loss. We emphasize the importance of diagnosis and the validity of treatment for intractable otitis media with eosinophils.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. nakataka@qent.med.kyushu-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Matsubara
authors.forename: Hideki
authors.initials: H
authors.lastname: Shiratsuchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kakazu
authors.forename: Torahiko
authors.initials: T
authors.lastname: Nakashima
authors.forename: Koji
authors.initials: K
authors.lastname: Koike
authors.forename: Toshiro
authors.initials: T
authors.lastname: Umezaki
authors.forename: Shizuo
authors.initials: S
authors.lastname: Komune
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D001844:Bone Conduction; D002908:Chronic Disease; D003131:Combined Modality Therapy; D018450:Disease Progression; D004802:Eosinophilia / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000175:diagnosis* / Q000628:therapy*; D012044:Regression Analysis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric