title: Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi.
abstract: Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.
authors.affiliation: Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Ting-Fai
authors.initials: TF
authors.lastname: Tso
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Jing-Zheng
authors.initials: JZ
authors.lastname: Song
authors.forename: Li-Jia
authors.initials: LJ
authors.lastname: Xu
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Yang
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D017368:Protein Prenylation; D012116:Resins, Plant / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012116:Resins, Plant; D044004:Xanthones