title: In vitro study of DP-bioglass paste for treatment of dentin hypersensitivity.
abstract: Sealing of exposed dentinal tubules is generally considered the most effective strategy to treat dentin hypersensitivity. On this account, we fabricated a DP-bioglass paste that created a homogeneous blockage on open dentinal tubules and formed a deep precipitate within dentinal tubules. DP-bioglass paste was prepared by mixing 20% to 60% phosphoric acid and DP-bioglass to treat dentin surfaces. CO2 laser irradiation was used to melt the DP-bioglass paste. The results demonstrated that 30% phosphoric acid was the optimum concentration to produce homogeneous occlusion on exposed dentinal tubules and 60 microm of sealing depth. CO2 laser irradiation could melt the DP-bioglass paste and create about 10 microm of sealing depth. Moreover, temperature rise during CO2 laser irradiation was only 4.86 +/- 0.47 degrees C. The results presented in this work suggested that DP-bioglass paste could produce considerable sealing depth in dentinal tubules with the potential of prolonging the therapeutic effect efficaciously.
authors.affiliation: Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei.
authors.forename: Bor-Shiunn
authors.initials: BS
authors.lastname: Lee
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Tsai
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Tsai
authors.forename: Wan-Hong
authors.initials: WH
authors.lastname: Lan
authors.forename: Chun-Pin
authors.initials: CP
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D018360:Crystallography, X-Ray; D003738:Dental Cements / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003804:Dentin / Q000648:ultrastructure; D003806:Dentin Permeability / Q000187:drug effects; D003807:Dentin Sensitivity / Q000188:drug therapy*; D006358:Hot Temperature; D006801:Humans; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D008963:Molar; D010756:Phosphoric Acids; D013052:Spectrometry, X-Ray Emission
chemical_list: C418024:DP-bioactive glass paste; D003738:Dental Cements; D010756:Phosphoric Acids; C030242:phosphoric acid