Cerebrovascular reactivity and vasospasm after subarachnoid hemorrhage: a pilot study.
The authors performed serial transcranial Doppler (TCD) and carbon dioxide reactivity (CO2R) testing in 20 aneurysmal subarachnoid hemorrhage patients to determine whether impaired cerebrovascular reactivity was associated with symptomatic vasospasm. Symptomatic vasospasm occurred in 9 of 14 patients with abnormal CO2R and in none of 6 patients with preserved reactivity (p = 0.011). Abnormal CO2R preceded the onset of vasospasm in 7 of 9 patients. Abnormal standard TCD testing was not associated with vasospasm.
Frontera
J A
JA
Division of Stroke and Neurocritical Care, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Rundek
T
T
Schmidt
J M
JM
Claassen
J
J
Parra
A
A
Wartenberg
K E
KE
Temes
R E
RE
Mayer
S A
SA
Mohr
J P
JP
Marshall
R S
RS
D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging / Q000209:etiology*
D002245:Carbon Dioxide