title: Determinants of bronchodilator responsiveness in patients with controlled asthma.
abstract: Short-term bronchodilator responsiveness to an inhaled ss 2 adrenergic agonist was assessed by changes in forced expiratory volume in 1 second (FEV(1)) in nonsmoking adults with controlled asthma (mild disease, 20 patients; moderate disease, 20 patients; severe disease, 18 patients). Responsiveness correlated significantly with age and with percent of predicted FEV(1) (%FEV(1)) except in patients with severe asthma, who showed significantly less responsiveness than others. Thus, responsiveness is closely associated with degree of airflow limitation in patients with controlled asthma and is significantly influenced by severity of disease and by aging.
authors.affiliation: First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan. kogat@med.kurume-u.ac.jp
authors.forename: Takeharu
authors.initials: T
authors.lastname: Koga
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kamimura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oshita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Narita
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mukaino
authors.forename: Munetsugu
authors.initials: M
authors.lastname: Nishimura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mizoguchi
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000420:Albuterol / Q000494:pharmacology; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000494:pharmacology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology; D012123:Pulmonary Ventilation / Q000187:drug effects / Q000502:physiology; D013147:Spirometry
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol