DNA double-strand break repair: a relentless hunt uncovers new prey.
A major pathway for repair of DNA double-strand breaks is nonhomologous end-joining (NHEJ). In this issue of Cell, and report the discovery of a new NHEJ factor called Cernunnos-XLF. Both groups report that this protein is mutated in a rare inherited human syndrome characterized by severe immunodeficiency, developmental delay, and hypersensitivity to agents that cause DNA double-strand breaks.
Sekiguchi
JoAnn M
JM
Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, 48109, USA
Ferguson
David O
DO
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans
D004268:DNA-Binding Proteins; C508551:NHEJ1 protein, human; D045643:DNA Repair Enzymes