[Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient].
A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.
Iyama
Satoshi
S
14th Department of Internal Medicine, Sapporo Medical University, School of Medicine.
Matsunaga
Takuya
T
Fujimi
Akihito
A
Murase
Kazuyuki
K
Kuribayasi
Kageaki
K
Sato
Tsutomu
T
Hirayama
Yasuo
Y
Sakamaki
Sumio
S
Kohda
Kyuhei
K
Niitsu
Yoshiro
Y
D000257:Adenoviridae Infections; D000284:Administration, Oral; D000741:Anemia, Aplastic / Q000628:therapy; D000998:Antiviral Agents / Q000008:administration & dosage*; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D051359:Lymphohistiocytosis, Hemophagocytic / Q000188:drug therapy* / Q000821:virology*; D008875:Middle Aged; D009894:Opportunistic Infections; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012254:Ribavirin / Q000008:administration & dosage*; D016896:Treatment Outcome
D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D012254:Ribavirin