Role of biologically active sphingolipids in tumor growth.
This review highlights the literature on the effects of biologically active sphingolipids (sphingosine, ceramide, sphingomyelin, glucosylceramide, gangliosides GM1, GM2, GM3, GD3, etc.) on proliferation, apoptosis, metastases, and invasiveness of tumor cells and the putative role of sphingolipids in chemotherapy of malignant tumors.
Dyatlovitskaya
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EV
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. dyatl@ibch.ru
Kandyba
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AG
D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D013107:Sphingolipids / Q000378:metabolism*
D013107:Sphingolipids