title: Solid-phase synthesis in the twenty-first century.
abstract: Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-beta-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the antimycobacterial cyclic depsipeptide natural product kahalalide A.
authors.affiliation: School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK. ganesan@soton.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Ganesan
mesh_terms: D000466:Alkadienes / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D006146:Guanidines / Q000138:chemical synthesis; D006827:Hydantoins / Q000138:chemical synthesis; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D010879:Piperazines / Q000138:chemical synthesis; D013777:Tetrazoles / Q000138:chemical synthesis; D014633:Valine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000068756:Valsartan
chemical_list: D000466:Alkadienes; D001896:Boron Compounds; D006146:Guanidines; D006827:Hydantoins; D008698:Mesylates; D010456:Peptides, Cyclic; D004364:Pharmaceutical Preparations; D010879:Piperazines; D013777:Tetrazoles; C100698:demethoxyfumitremorgin C; C499137:kahalalide A; C439868:1,5-cyclooctadiene; C004267:9-borabicyclo(3,3,1)nonane; D000068756:Valsartan; D014633:Valine