title: How cyclodextrins can mask their toxic effect on the blood-brain barrier.
abstract: The toxicity of monosubstituted n-alkyldimethylammonium-beta-cyclodextrins (DMA-C(n)-CD with n=2, 4 and 12) towards endothelial cells of an in vitro model of the blood-brain barrier (BBB) was evaluated and compared to that of the native beta-CD. DMA-C(12)-CD was found to be non-toxic below 10mM due to the self-inclusion of the alkyl chain in the CD cavity. A high percentage of passage (30%) of DMA-C(12)-CD through the endothelial cells has been measured.
authors.affiliation: Laboratoire de Physico-Chimie des Interfaces et Applications, FRE CNRS 2485, Faculté des Sciences Jean Perrin, Université d'Artois, rue Jean Souvraz, SP.18-62307 Lens Cédex, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Binkowski-Machut
authors.forename: Frédéric
authors.initials: F
authors.lastname: Hapiot
authors.forename: Patrick
authors.initials: P
authors.lastname: Martin
authors.forename: Roméo
authors.initials: R
authors.lastname: Cecchelli
authors.forename: Eric
authors.initials: E
authors.lastname: Monflier
mesh_terms: D001812:Blood-Brain Barrier / Q000187:drug effects*; D003505:Cyclodextrins / Q000633:toxicity*
chemical_list: D003505:Cyclodextrins