title: Preliminary evaluation of anticonvulsant activity of some aroxyacetamides and aroxyethylamines.
abstract: A series of aroxyacetamides and aroxyethylamines were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX). Most of them exhibited anticonvulsant activity in the MES screen (mice, i.p.) in the doses up to 300 mg/kg b.w. The most active compound was XVI, which given in the dose 100 mg/kg b.w. produced 100% anticonvulsant protection after 0.5 h without neurotoxicity. The most promising compound in the VIa phase (rats, p.o.) was VIII, which produced higher anticonvulsant protection (to 75% at 0.5 h).
authors.affiliation: Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
authors.forename: Henryk
authors.initials: H
authors.lastname: Marona
authors.forename: Anna M
authors.initials: AM
authors.lastname: Waszkielewicz
authors.forename: Edward
authors.initials: E
authors.lastname: Szneler
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D003292:Convulsants; D004597:Electroshock; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D003292:Convulsants; D005021:Ethylamines; D010433:Pentylenetetrazole