[Nanoparticles prepared with PLA derivatives].
Chemical modification of poly (DL-lactic acid) (PLA) is very important to give it various functionalities. When hydrophilic moieties are combined to PLA, the products tend to form the nanoparticles with the hydrophilic moieties as their shell and PLA as a core in aqueous medium. The nanoparticles produced with such PLA derivatives are also expected to exhibit various functions physicochemically and physiologically. Further, they can work well as a valuable depot of biologically active reagents. In this section, the preparative procedure of PLA derivaties and several nanoparticles prepared with PLA derivatives are introduced. Moreover, the physicochemical and biopharmaceutical characteristics of the nanoparticles are overviewed.
Onishi
Hiraku
H
Department of Drug Delivery Research, Hoshi University.
Machida
Yoshiharu
Y
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019344:Lactic Acid / Q000737:chemistry*; D049329:Nanostructures; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*
D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)