title: Intradialytic parenteral nutrition: comparison of olive oil versus soybean oil-based lipid emulsions.
abstract: Lipid, oxidative and inflammatory parameters are frequently altered in dialysis patients and may be worsened by intravenous lipid emulsions (ILE). We assessed the efficacy and tolerance of olive as compared with standard soybean oil-based ILE during intradialytic parenteral nutrition (IDPN). IDPN mixtures containing amino acids, glucose, and either olive oil (OO group, n 17) or soybean oil-based ILE (SO group, n 18) were administered in a 5-week randomized, double-blind study. On days 0 and 35, patients' nutritional status was assessed by BMI, normalized protein catabolic rate, predialytic creatinine, serum albumin and transthyretin; lipid metabolism by plasma LDL- and HDL-cholesterol, triacylglycerols, phospholipids, apo A-I, A-II, B, C-II, C-III, E and lipoprotein (a); oxidative status by alpha-tocopherol, retinol, selenium, glutathione peroxidase, malondialdehyde and advanced oxidized protein products; inflammatory status by serum C-reactive protein, orosomucoid, IL-2 and IL-6. No serious adverse event was observed. Significant changes were observed from day 0 to day 35 (P<0.05): nutritional criteria improved (albumin in OO; albumin, transthyretin and creatinine in SO); LDL-cholesterol, apo B, C-II, C-III and apo A-I/A-II ratio increased in both groups. HDL-cholesterol decreased in OO; apo E increased and lipoprotein (a) decreased in SO; alpha-tocopherol/cholesterol ratio increased in OO; malondialdehyde decreased in both groups; IL-2 increased in both groups. The between-group comparison only showed the following differences: alpha-tocopherol/cholesterol increased in OO; lipoprotein (a) decreased in SO. From these data, it was concluded that OO- and SO-based IDPNs similarly improved nutritional status and influenced plasma lipid, oxidative, inflammatory and immune parameters.
authors.affiliation: Service d'Hépatogastroentérologie et Nutrition, Clinique Résidence du Parc, Rue Gaston Berger, 13362, Marseille cedex 10, France. njm.cano@wanadoo.fr
authors.forename: Noël J M
authors.initials: NJ
authors.lastname: Cano
authors.forename: Yannick
authors.initials: Y
authors.lastname: Saingra
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dupuy
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Lorec-Penet
authors.forename: Henri
authors.initials: H
authors.lastname: Portugal
authors.forename: Denis
authors.initials: D
authors.lastname: Lairon
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Adrien
authors.initials: A
authors.lastname: Come
authors.forename: Alexia
authors.initials: A
authors.lastname: Le Brun
authors.forename: Philippe
authors.initials: P
authors.lastname: Atlan
authors.forename: Xavier M
authors.initials: XM
authors.lastname: Leverve
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D009748:Nutrition Disorders / Q000276:immunology / Q000628:therapy; D000069463:Olive Oil; D018384:Oxidative Stress; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods*; D010743:Phospholipids / Q000097:blood; D010938:Plant Oils / Q000008:administration & dosage*; D011446:Prospective Studies; D006435:Renal Dialysis; D013024:Soybean Oil / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D005217:Fat Emulsions, Intravenous; D000069463:Olive Oil; D010743:Phospholipids; D010938:Plant Oils; D014280:Triglycerides; D013024:Soybean Oil; D002784:Cholesterol