Chloride ion efflux from liposomes is controlled by sidechains in a channel-forming heptapeptide.
A suite of amphiphilic heptapeptides incorporating a glutamic acid derivative on the C-terminal side of a (Gly)(3)Pro sequence gives dramatically lower chloride ion release from liposomes when present in free carboxyl form rather than as an ester or amide.
You
Lei
L
Department of Chemistry, Washington University, 1 Brookings Drive, St. Louis, MO 63130, USA.
Ferdani
Riccardo
R
Gokel
George W
GW
D000577:Amides / Q000737:chemistry; D000595:Amino Acid Sequence; D002264:Carboxylic Acids / Q000737:chemistry; D018118:Chloride Channels / Q000737:chemistry* / Q000378:metabolism; D002712:Chlorides / Q000737:chemistry* / Q000378:metabolism; D004952:Esters / Q000737:chemistry; D018698:Glutamic Acid / Q000031:analogs & derivatives; D007477:Ions; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D004364:Pharmaceutical Preparations; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D011392:Proline / Q000737:chemistry; D011485:Protein Binding; D013997:Time Factors
D000577:Amides; D002264:Carboxylic Acids; D018118:Chloride Channels; D002712:Chlorides; D004952:Esters; D007477:Ions; D008081:Liposomes; D009842:Oligopeptides; D004364:Pharmaceutical Preparations; D010743:Phospholipids; D018698:Glutamic Acid; D011392:Proline