title: Concise synthesis of 22-hydroxyacuminatine, cytotoxic camptothecinoid from Camptotheca acuminata, by pyridone benzannulation.
abstract: A short, efficient synthesis of 22-hydroxyacuminatine, starting from a readily accessible hydroxy pyridone, is presented; key steps include a Heck coupling with methyl pentadienoate, a flash vacuum pyrolytic cyclization, and a Friedländer condensation.
authors.affiliation: Université Joseph Fourier de Grenoble, Chimie Recherche (LEDSS), 38041, Grenoble, France.
authors.forename: Matej
authors.initials: M
authors.lastname: Babjak
authors.forename: Alice
authors.initials: A
authors.lastname: Kanazawa
authors.forename: Regan J
authors.initials: RJ
authors.lastname: Anderson
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Greene
mesh_terms: D029769:Camptotheca / Q000737:chemistry*; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*
chemical_list: C508964:22-hydroxyacuminatine; D007212:Indolizines; D011728:Pyridones; D011804:Quinolines