title: Nasal airflow recovery after decongestion test is associated with bronchial hyperreactivity in patients with allergic rhinitis.
abstract: BACKGROUND
  The decongestion test involves spraying an intranasal vasoconstrictor drug to evaluate the recovery of nasal airflow.
  
  
  OBJECTIVE
  The aim of this study was to assess the relationship between pulmonary function (assessed by spirometry and methacholine challenge) and nasal airflow recovery after a topical vasoconstrictor had been administered in patients with allergic rhinitis (perennial, seasonal, or mixed allergic rhinitis).
  
  
  METHODS
  A total of 150 subjects were studied. The total symptom score, sensitization, and pulmonary function were all assessed. All subjects underwent rhinomanometry and the decongestion test.
  
  
  RESULTS
  Univariate analysis revealed that nasal symptoms and spirometric parameters (except FEF(25-75) in subjects with seasonal allergic rhinitis) were not. Only bronchial hyperreactivity, assessed by methacholine challenge, proved to be significantly (and independently) associated with outcome (OR 1.45, P = 0.025).
  
  
  CONCLUSIONS
  This study provides the first evidence of an association between a positive response to the decongestion test and bronchial hyperreactivity, assessed by methacholine challenge, in patients with allergic rhinitis.
authors.affiliation: Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. gio.cip@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ciprandi
authors.forename: Ignazio
authors.initials: I
authors.lastname: Cirillo
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Andrea
authors.initials: A
authors.lastname: Vizzaccaro
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Tosca
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
mesh_terms: D000328:Adult; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D006801:Humans; D008297:Male; D009666:Nose / Q000503:physiopathology*; D012220:Rhinitis; D012221:Rhinitis, Allergic, Perennial / Q000503:physiopathology*; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D013147:Spirometry