title: Mechanisms of immune-mediated skin diseases: an overview.
abstract: The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments.These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or autoantibody dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-mediated disorders. In some instances (e.g., psoriasis and atopic dermatitis) genetic predisposition can affect also the capacity of keratinocytes to initiate or perpetuate inflammatory responses. A more precise understanding of the molecular and cellular mechanisms underlying each disorder may allow the identification of novel targets for more effective therapeutic strategies.
authors.affiliation: Department of Dermatology, University of Münster, Münster, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Beissert
authors.forename: I
authors.initials: I
authors.lastname: Cavazzana
authors.forename: F
authors.initials: F
authors.lastname: Mascia
authors.forename: P
authors.initials: P
authors.lastname: Meroni
authors.forename: S
authors.initials: S
authors.lastname: Pastore
authors.forename: G
authors.initials: G
authors.lastname: Tessari
authors.forename: G
authors.initials: G
authors.lastname: Girolomoni
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology; D002908:Chronic Disease; D003872:Dermatitis / Q000276:immunology; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D019013:CD40 Antigens; D023201:CD40 Ligand