title: New aldose reductase inhibitors N99-596 A and B from Streptomyces.
abstract: The actinomycete Streptomyces diannanensis, isolated from a soil sample collected in Yunnan province, China, was found to produce two novel isoflavone rhamnopyranosides, namely, 7,4'-dihydroxyisoflavone 3'-O-alpha-L-rhamnopyranoside (1) and 5,7,4'-trihydroxyisoflavone 3'-O-alpha-L-rhamnopyranoside (2). The structures of 1 and 2 were elucidated on the basis of extensive 1D and 2D NMR and MS spectral analyses. Compounds 1 and 2 exhibited in vitro activities against aldose reductase with an IC50 of 170 and 165 microM, respectively.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People's Republic of China. jsyang2005@yahoo.cn
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Dong
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
authors.forename: Xiao
authors.initials: X
authors.lastname: Ren
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Jiangong
authors.initials: J
authors.lastname: He
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012210:Rhamnose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D013552:Swine
chemical_list: D004791:Enzyme Inhibitors; D007529:Isoflavones; C508106:N99-596 A; C508107:N99-596 B; D000449:Aldehyde Reductase; D012210:Rhamnose