title: Evolution of cerebral arteriopathies in childhood arterial ischemic stroke.
abstract: OBJECTIVE
  To investigate evolution of cerebral arteriopathy in children with arterial ischemic stroke (AIS) and its influence on recurrence.
  
  
  METHODS
  Arteriopathy severity was graded on serial magnetic resonance angiograms from 50 children with first AIS; diagnostic categories were assigned.
  
  
  RESULTS
  Arteriopathy affected 72 arteries in 43 of 50 children. Five had clinical recurrence, with reinfarction in four; another had clinically silent reinfarction. Twelve children (24%; 4 with recurrence) had progressive arteriopathy. Arteriopathy improved in 24 patients (including 1 with recurrent transient ischemic attacks) and was stable in 7 patients. Magnetic resonance angiograms remained normal in seven patients; one had recurrent stroke. Diagnoses were transient cerebral arteriopathy (n = 24), chronic cerebral arteriopathy (n = 11), arterial dissection (n = 3), possible moyamoya (n = 2), primary moyamoya (n = 1), dysplastic arteriopathy (n = 1), and cerebral vasculitis (n = 1). Some of the first two categories could represent thromboembolic arterial occlusion with recanalization. The hazard of recurrence was three times higher when arterial disease had progressed (Cox regression hazard ratio, 3.2; 95% confidence intervals, 0.5-20.3; p = 0.22). After adjustment for age and number of AIS risk factors, the hazard ratio was 3.1 (95% confidence interval, 0.4-22.2; p = 0.27).
  
  
  CONCLUSIONS
  Arteriopathy frequently progresses after childhood AIS. Further studies are needed to examine the relationship between progressive arteriopathy and recurrence.
authors.affiliation: Department of Radiology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
authors.forename: Nasuda
authors.initials: N
authors.lastname: Danchaivijitr
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Cox
authors.forename: Dawn E
authors.initials: DE
authors.lastname: Saunders
authors.forename: Vijeya
authors.initials: V
authors.lastname: Ganesan
mesh_terms: D000293:Adolescent; D002533:Cerebral Angiography / Q000379:methods; D002539:Cerebral Arterial Diseases / Q000145:classification* / Q000175:diagnosis*; D002561:Cerebrovascular Disorders / Q000145:classification* / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D002941:Circle of Willis / Q000473:pathology; D003710:Demography; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies