title: Periodontal and hematological characteristics associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis.
abstract: BACKGROUND
  Periodontitis shares several clinical and pathogenic characteristics with chronic arthritis, and there is some degree of coexistence. The aims of this study were to elucidate whether patients with localized aggressive periodontitis (LAgP), generalized aggressive periodontitis (GAgP), juvenile idiopathic arthritis (JIA), and rheumatoid arthritis (RA) share periodontal and hematological characteristics distinguishing them from individuals free of diseases.
  
  
  METHODS
  The study population consisted of white adults (<or=35 years old) with LAgP (N=18), GAgP (N=27), JIA (N=10), RA (N=23), and healthy controls (N=25). All individuals underwent a standardized interview, blood sampling, and an intraoral examination, including registration of plaque, bleeding on probing, probing depth (PD), clinical attachment loss (CAL), and alveolar bone loss (ABL) on radiographs. Blood samples were analyzed for erythrocyte fraction, leukocytes and differential counts, erythrocyte sedimentation rate, C-reactive protein (CRP), immunoglobulin (Ig) M and IgA rheumatoid factors (RFs), and antibodies to cyclic citrullinated peptides.
  
  
  RESULTS
  RA patients had a higher percentage of sites with PD>or=4 mm, CAL>or=2 mm, and ABL>or=2 mm compared to controls. The percentage of sites with CAL>or=2 mm significantly correlated with the levels of IgM-RF and IgA-RF. Missing teeth in JIA and RA patients were not lost due to periodontitis. Patients with GAgP showed higher levels of leukocytes, including neutrophils, and CRP compared to controls. In part, JIA and RA patients showed similar results.
  
  
  CONCLUSIONS
  Young adults with RA may develop periodontal destruction, and these patients require professional attention. Both differences and similarities in periodontal and hematological variables were seen in individuals with periodontitis, JIA, and RA.
authors.affiliation: Department of Periodontology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, and Department of Rheumatology, Copenhagen County Hospital, Hvidovre, Denmark. ah@odont.ku.dk
authors.forename: Anne
authors.initials: A
authors.lastname: Havemose-Poulsen
authors.forename: Jytte
authors.initials: J
authors.lastname: Westergaard
authors.forename: Kaj
authors.initials: K
authors.lastname: Stoltze
authors.forename: Henrik
authors.initials: H
authors.lastname: Skjødt
authors.forename: Bente
authors.initials: B
authors.lastname: Danneskiold-Samsøe
authors.forename: Henning
authors.initials: H
authors.lastname: Locht
authors.forename: Klaus
authors.initials: K
authors.lastname: Bendtzen
authors.forename: Palle
authors.initials: P
authors.lastname: Holmstrup
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000145:classification; D001171:Arthritis, Juvenile / Q000097:blood / Q000150:complications*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications*; D001323:Autoantibodies / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003774:Dental Plaque Index; D004906:Erythrocyte Count; D005260:Female; D005884:Gingival Hemorrhage / Q000145:classification; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D010456:Peptides, Cyclic; D017622:Periodontal Attachment Loss / Q000145:classification; D010514:Periodontal Pocket / Q000145:classification; D010518:Periodontitis / Q000097:blood / Q000145:classification / Q000150:complications*; D012217:Rheumatoid Factor / Q000097:blood
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D002097:C-Reactive Protein; D012217:Rheumatoid Factor