Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates.
Two novel axially substituted phthalocyanines, namely bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon (IV) (1) and its N-methylated derivative 2, have been synthesized. The dicationic phthalocyanine 2 is non-aggregated in water and exhibits good photophysical properties. The non-covalent BSA conjugates of these compounds have also been prepared. Compound 2 and the conjugate 2-BSA show extremely high photodynamic activities toward B16 melanoma cancer cell lines. The corresponding 50% growth-inhibitory (IC50) ratios are 33 and 38 nM, respectively.
Jiang
Xiong-Jie
XJ
College of Chemistry and Chemical Engineering, Institute of Research on Functional Materials, Fuzhou University, Fuzhou 350002, China.
Huang
Jian-Dong
JD
Zhu
Yu-Jiao
YJ
Tang
Fen-Xiang
FX
Ng
Dennis K P
DK
Sun
Jian-Cheng
JC
D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013237:Stereoisomerism
D007211:Indoles; D017646:Organosilicon Compounds; D017319:Photosensitizing Agents; C511135:bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon; C082854:silicon phthalocyanine; D012710:Serum Albumin, Bovine