[Human herpesvirus 6 and multiple sclerosis].
In this work the possible etiologic relationship among the multiple sclerosis and the herpesvirus 6 (VHH-6) has been studied, subject debated in the last years. They have been carried out two studies using blood and LCR of sick of multiple sclerosis, and control in healthy fellows and with other neurological illnesses. The followed techniques are described to isolate the virus, their DNA, and the antibodies IgG and IgA in front of the VHH-6. The presente of the VHH-6 has not been demonstrated neither of its DNA in any case, but if it has been proved, with statistical significance that in the sick persons with buds of multiple sclerosis, the antibodies of the type IgG, as much in plasm as in LCR, was more present and in higher levels that in the controls.
Piédrola Angulo
Gonzalo
G
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis / Q000097:blood; D002555:Cerebrospinal Fluid / Q000276:immunology; D004279:DNA, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000821:virology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013030:Spain / Q000453:epidemiology
D000914:Antibodies, Viral; D004279:DNA, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G