title: Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete.
abstract: BACKGROUND
  Only one study has investigated the relationship of essential fatty acids in the adipose tissue with depression in adults and suggested an inverse relationship between docosahexaenoic acid (22:6 n-3) (DHA) and depression.
  
  
  OBJECTIVE
  To examine the relation between adipose tissue polyunsaturated fatty acids especially n-3 and n-6 fatty acids, an index of long-term or habitual fatty acid intake, and depression in adults.
  
  
  METHODS
  Cross-sectional study of healthy adults from the island of Crete.
  
  
  METHODS
  The Preventive Medicine and Nutrition Clinic, University of Crete, Greece.
  
  
  METHODS
  A total of 130 healthy adults (59 males, 71 females) aged 22-58 years. The sample was a sub-sample of the Greek ApoEurope study group.
  
  
  METHODS
  Fatty acids were determined by gas chromatography in adipose tissue. Information about depression was obtained through the Zung Self-rating Depression Scale.
  
  
  RESULTS
  Adipose tissue DHA was inversely related with depression. Multiple linear regression analysis taking into account the possible confounding effect of age, gender, body mass index, smoking and educational level confirmed this association.
  
  
  CONCLUSIONS
  The inverse relationship between adipose DHA and depression in adults, replicates findings of a previous study. This relationship indicates that a low long-term dietary intake of DHA is associated with an increased risk for depression in adults.
authors.affiliation: Department of Social Medicine Preventive Medicine and Nutrition, School of Medicine, University of Crete, Iraklion, Crete, Greece. geor40@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Mamalakis
authors.forename: N
authors.initials: N
authors.lastname: Kalogeropoulos
authors.forename: N
authors.initials: N
authors.lastname: Andrikopoulos
authors.forename: C
authors.initials: C
authors.lastname: Hatzis
authors.forename: D
authors.initials: D
authors.lastname: Kromhout
authors.forename: J
authors.initials: J
authors.lastname: Moschandreas
authors.forename: A
authors.initials: A
authors.lastname: Kafatos
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry* / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D002849:Chromatography, Gas / Q000379:methods; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology*; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000032:analysis*; D005247:Feeding Behavior; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D004281:Docosahexaenoic Acids