Adult-onset infective dermatitis associated with HTLV-I. Clinical and immunopathological aspects of two cases.
Infective dermatitis associated with HTLV-I (IDH) is a chronic, infected childhood eczema. Two adult-onset cases of IDH were studied, one of which was associated with HAM/TSP. The patients were submitted to dermatological, neurological and pathological examination. Immunohistochemical studies were made using CD3, CD4, CD8, CD20, CD79a, and CD57 antibodies. Cytotoxic granules were investigated using granzyme B, perforin, and TIA. The patients presented infected erythematous, scaly lesions with mild itching and a good response to sulfamethoxazole/ trimethoprim. A differential diagnosis with atopic dermatitis (AD) and seborrheic dermatitis (SD) was made, based on: the distinctive morphology and distribution of the lesions, presence of exudative and infected lesions, and mild pruritus. The inflammatory infiltrate was composed predominantly of CD8+ lymphocytes that did not present cytotoxic granules. We concluded that IDH can begin in adulthood and may be associated with HAM/TSP. The immunohistochemical findings were different from those observed in AD and SD.
Bittencourt
Achiléa L
AL
Department of Pathology, Hospital Universitário Prof. Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil. achilea@uol.com.br
Oliveira
Maria de Fátima
Mde F
Ferraz
Neide
N
Vieira
Maria das Graças
Md
Muniz
André
A
Brites
Carlos
C
D000328:Adult; D001707:Biopsy, Needle; D001938:Brazil; D005260:Female; D005500:Follow-Up Studies; D015490:HTLV-I Infections / Q000188:drug therapy / Q000473:pathology*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012720:Severity of Illness Index; D017193:Skin Diseases, Viral / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D015662:Trimethoprim, Sulfamethoxazole Drug Combination