CD4 cell recovery in treated HIV-2-infected adults is lower than expected: results from the French ANRS CO5 HIV-2 cohort.
In 61 antiretroviral-naive HIV-2-infected patients starting triple therapy at a median CD4 cell count of 136 cells/microl, the median increase was 41 cells/microl at month 12, which was no different among those on protease inhibitors or triple nucleoside analogues. Despite virological response, as the median plasma load was under the detectable threshold from month 3, CD4 cell recovery remained poor in treated HIV-2 infection. Our results raise the question of the optimal regimen to recommend in HIV-2-infected patients.
Matheron
Sophie
S
Bichat Claude Bernard Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Damond
Florence
F
Benard
Antoine
A
Taieb
Audrey
A
Campa
Pauline
P
Peytavin
Gilles
G
Pueyo
Sophie
S
Brun-Vezinet
Francoise
F
Chene
Genevieve
G
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects*; D015331:Cohort Studies; D018450:Disease Progression; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015498:HIV-2; D006801:Humans; D019562:Viral Load