[Hormone-dependence and C-ERBB2: relationship between estrogen receptor expression, estrogen-regulated proteins, and C-ERBB2 in breast carcinoma].
We reviewed 1491 consecutive cases of operated breast cancer between 1999-2004, and found that hormone-dependence, particularly if evaluated with functional markers of the estrogen receptor (estrogen regulated proteins, ERP), is inversely proportional to antigen neu expression. Our data confirms that ERP can give additional information on the probability of response to hormonal therapy.
Costarelli
L
L
UOC Anatomia e Istologia Patologica, Citologia Diagnostica, Genetica Medica, Azienda Ospedaliera S Giovanni-Addolorata-Calvary Hospital.
Piro
F R
FR
Fortunato
L
L
Vitelli
C E
CE
Farina
M
M
Taffuri
M
M
Amini
M
M
D001943:Breast Neoplasms / Q000235:genetics*; D015870:Gene Expression; D018734:Genes, erbB-2 / Q000235:genetics*; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D011960:Receptors, Estrogen / Q000096:biosynthesis*
D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; C038865:estrogen regulated protein