Sunflower seed oil-enriched product can inhibit Ehrlich solid tumor growth in mice.
BACKGROUND
Sunflower seed oil (SSO) effect on solid and ascitic forms of Ehrlich tumor was evaluated.


METHODS
Solid or ascitic Ehrlich tumor-bearing Swiss mice were treated daily, by subcutaneous route, with 200 microl of SSO. The solid tumor-bearing footpad was measured every 3 days and ascitic tumor-bearing mice had their ascites collected and quantified. At the end of the SSO treatment, the total cell number in lymphoid organs was quantified.


RESULTS
Subcutaneous treatment with SSO inhibits the solid tumor growth and increases lymph node cell number in animals with solid tumor, but has no effect on animals with ascitic tumor.


CONCLUSIONS
SSO can delay the solid tumor growth, possibly due to better absorption of this treatment by draining lymph nodes.
Silva
Lucilene A
LA
Laboratory of Immunophysiology, Department of Pathology, Federal University of Maranhão, São Luís, Brazil.
Nascimento
Kátia A F
KA
Maciel
Márcia C G
MC
Pinheiro
Mayara T
MT
Sousa
Paulo R A
PR
Ferreira
Susanne C P
SC
Azevedo
Ana Paula S
AP
Guerra
Rosane N M
RN
Nascimento
Flávia R F
FR
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D007279:Injections, Subcutaneous; D051379:Mice; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D000074242:Sunflower Oil
D010938:Plant Oils; D000074242:Sunflower Oil