title: Tissue-specific expression of Clec2g in mice.
abstract: Estrogens regulate the proliferation and differentiation of mouse vaginal epithelial cells. We examined the temporal and spatial expression of DDV10, a novel C-type lectin during stratification and cornification of the vaginal epithelium. DDV10 was expressed in vagina but not uterus in ovariectomized mice treated with 17beta-estradiol (E2). In mouse stomach, the expression of DDV10 was detected in pars proventricularis but not in pars glandularis. Furthermore, the DDV10 gene was found to possess two transcripts, a long form (DDV10) and a short form (OCILrP1, osteoclast inhibitory lectin-related protein 1). DDV10 mRNA but not OCILrP1 mRNA was expressed in the stratified and cornified epithelial tissues. DDV10 mRNA was first detected between 12 and 18 h after E2 treatment in the vaginal epithelium, and was detected in the vagina of the neonatally diethylstilbestrol (DES)-treated mouse. Recently, a unified name was registered in GenBank (C-type lectin domain family 2, member g; Clec2 g). Taken together, these data suggest that DDV10 is the long form of Clec2 g (Clec2g-L), and DDV10/Clec2g-L may play a role in the stratification and/or cornification of epithelial cells during differentiation.
authors.affiliation: Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan.
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Katsu
authors.forename: Taisen
authors.initials: T
authors.lastname: Iguchi
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004054:Diethylstilbestrol / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000378:metabolism; D005260:Female; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010052:Ovariectomy; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D013270:Stomach / Q000166:cytology / Q000502:physiology; D014018:Tissue Distribution; D014599:Uterus / Q000166:cytology / Q000378:metabolism; D014621:Vagina / Q000166:cytology* / Q000502:physiology
chemical_list: C474862:DDV10 protein, mouse; D004968:Estrogens, Non-Steroidal; D037181:Lectins, C-Type; D008565:Membrane Proteins; C470571:Ocilrp1 protein, mouse; D020033:Protein Isoforms; D012333:RNA, Messenger; D004958:Estradiol; D004054:Diethylstilbestrol