[Stress, hormones, and neuronal signals in the pathophysiology of rheumatoid arthritis. The negative impact on chronic inflammation].
This review demonstrates that hormonal and neuronal factors, which are released during stressful situations, can unfavorably influence the two chronic diseases of rheumatoid arthritis and juvenile idiopathic arthritis. Noradrenaline and cortisol are in the focus of this review. In the said two chronic inflammatory diseases, it is obvious that apart from the immune system also the endocrine and nervous system play an essential role in the stress-induced initiation and aggravation of these diseases.
Straub
Rainer H
RH
Labor für Experimentelle Rheumatologie und Neuroendokrino-Immunologie, Klinik und Poliklinik für Innere Medizin I, Klinikum der Universität Regensburg, 93042 Regensburg. rainer.straub@klinik.uni-regensburg.de
Härle
Peter
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D001143:Arousal / Q000502:physiology*; D001171:Arthritis, Juvenile / Q000276:immunology* / Q000523:psychology; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000523:psychology; D002490:Central Nervous System / Q000503:physiopathology; D002648:Child; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology*; D018836:Inflammation Mediators / Q000097:blood; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D017933:Peripheral Nervous System / Q000503:physiopathology; D011598:Psychoneuroimmunology; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013315:Stress, Psychological / Q000150:complications* / Q000276:immunology; D009435:Synaptic Transmission / Q000502:physiology*
D018836:Inflammation Mediators; D006854:Hydrocortisone; D009638:Norepinephrine