Chemotherapy-induced alterations in ovarian sex cord tumor with annular tubules (SCTAT): a diagnostic challenge.
We present a case of ovarian sex cord tumor with annular tubules (SCTAT) in a patient that received neoadjuvant chemotherapy with 3.5 years of follow-up. Neo-adjuvant chemotherapy is a common practice in advanced cases of ovarian carcinoma and is rarely applied in nonepithelial ovarian tumors. Chemotherapy-induced morphologic alterations of the subsequently resected tissue samples are well recognized; in this case, chemotherapy-induced cytoarchitectural changes created diagnostic difficulties in the subsequently resected specimen.
Khalifa
Mahmoud
M
Department of Pathology, Sunnybrook and Women's College Health Sciences Center, Toronto, Ont., Canada M4N 3M5. Mahmoud.khalifa@sw.ca
Nofech-Mozes
Sharon
S
Atri
Mostafa
M
Covens
Allan
A
D000328:Adult; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D018312:Sex Cord-Gonadal Stromal Tumors / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome