title: [The correlation between polymorphism at position -511C/T in the promoter region of interleukin 1B and the severity of coronary heart disease].
abstract: OBJECTIVE
  To investigate the correlation between polymorphism at position -511C/T in the promoter region of interleukin 1B (IL1B) and the severity of coronary heart disease (CHD).
  
  
  METHODS
  The polymerase chain reaction-restriction fragment length polymorphism technique was applied to analyze the polymorphisms of IL1B -511C/T in 127 patients with CHD and 152 controls. And the serum level of lipoproteins was detected by enzymology method.
  
  
  RESULTS
  The distribution of IL1B -511C/T polymorphism between acute coronary syndrome (ACS) patients and controls was significantly different (chi-square test=5.72, P<0.01). CT and TT genotype carriers were in increased risk of ACS with more double ratio to CC genotype (OR=2.56, 95%CI=1.17-5.59). In CHD group, total cholesterol and low density lipoprotein-cholesterol levels of patients with CT and TT genotypes (6.09+/-0.97 mmol/L and 3.97+/-0.92 mmol/L) were significantly higher than those of patients with CC genotype (5.12+/-0.56 mmol/L and 2.87+/-0.71 mmol/L, P<0.05).
  
  
  CONCLUSIONS
  The polymorphism at position -511C/T in IL1B is associated with the severity of CHD, and the DNA variation at this position may affect the secretion of IL1B, and aggravate the reaction of inflammation and dyslipoidemia.
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumq, Xinjiang 830054, P.R.China. zymdxx@163.com
authors.forename: Yuan-ming
authors.initials: YM
authors.lastname: Zhang
authors.forename: Liang-jun
authors.initials: LJ
authors.lastname: Zhong
authors.forename: Bing-xian
authors.initials: BX
authors.lastname: He
authors.forename: Wen-chao
authors.initials: WC
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.forename: Xiao-tao
authors.initials: XT
authors.lastname: Chen
mesh_terms: D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D053583:Interleukin-1beta; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: C508585:IL1B protein, human; D007375:Interleukin-1; D053583:Interleukin-1beta