title: Oral manifestations in selective IgA deficiency.
abstract: Selective immunoglobulin A (IgA) deficiency is the most common of the primary immunodeficiencies with a frequency of 1/300-1/3000, depending on the screened population. As secretory IgA (SIgA) has a protective role in mucosal surfaces from invasion of microorganisms, it is thought that IgA-deficient subjects are susceptible to periodontal diseases and oral manifestations. Previous studies show contradictory results, concerning the involvement of the individuals' periodontium with IgA deficiency. The aim of this study was to investigate and compare the oral manifestations in IgA-deficient subjects with controls. Eleven selective IgA-deficient subjects aged 3-18 years with serum IgA levels <10 mg dl(-1) and 11 age-sex-matched healthy children as the controls entered the study. Oral mucosal investigation, dental caries, plaque accumulation and periodontal status were assessed. Serum immunoglobulin levels were measured by single radial immunodiffusion (SRID) method. Saliva immunoglobulins and secretory component levels were measured by enzyme linked immunosorbent assay (ELISA) methods. IgA-deficient patients had serum and saliva IgA levels less than 10 mg dl(-1) and 10 microg ml(-1), respectively, but other serum immunoglobulin levels were normal and saliva immunoglobulin M (IgM) levels were increased, compared with controls. There were no significant differences in oral manifestations between IgA-deficient subjects and controls, which may be a result of compensatory increase of saliva IgM or other non-immunological defence factors in saliva. Thus, it is not necessary to evaluate IgA and SIgA in all the patients with oral and dental lesions and it is thought that it is better to investigate other factors.
authors.affiliation: Pediatric Dentistry Department, Faculty of Dentistry, Tehran University of Medical Science, Tehran, Iran.
authors.forename: J
authors.initials: J
authors.lastname: Nikfarjam
authors.forename: Z
authors.initials: Z
authors.lastname: Pourpak
authors.forename: M
authors.initials: M
authors.lastname: Shahrabi
authors.forename: L
authors.initials: L
authors.lastname: Nikfarjam
authors.forename: A
authors.initials: A
authors.lastname: Kouhkan
authors.forename: M
authors.initials: M
authors.lastname: Moazeni
authors.forename: A
authors.initials: A
authors.lastname: Aghamohammadi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000097:blood*; D007070:Immunoglobulin A / Q000097:blood*; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D008297:Male; D009061:Mouth Mucosa / Q000276:immunology*; D010510:Periodontal Diseases / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D012472:Salivation / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory