title: Lichenicolins A and B, new bisnaphthopyrones from an unidentified lichenicolous fungus, strain LL-RB0668.
abstract: Lichenicolous fungus LL-RB0668 was isolated from a processed lichen thallus on a modified Lilly-Barnett solid medium. Two new bisnaphthopyrone compounds, lichenicolins A (1) and B (2), were isolated from the culture broth of this organism fermented on a rice-based solid medium. These results demonstrate that lichen-associated fungi potentially are a good resource for new bioactive natural products for current screening programs.
authors.affiliation: Natural Products Research, Chemical and Screening Sciences, Wyeth 401 N. Middletown Road, Pearl River, NY 10965, USA. heh@wyeth.com
authors.forename: Haiyin
authors.initials: H
authors.lastname: He
authors.forename: Ramunas
authors.initials: R
authors.lastname: Bigelis
authors.forename: Hui Y
authors.initials: HY
authors.lastname: Yang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Chang
authors.forename: Maya P
authors.initials: MP
authors.lastname: Singh
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003470:Culture Media / Q000737:chemistry; D005285:Fermentation; D005658:Fungi / Q000302:isolation & purification / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; D011753:Pyrones