Reversible Parkinsonian syndrome associated with anti-neuronal antibodies in acute EBV encephalitis: a case report.
We report a case of subacute-onset isolated parkinsonian syndrome in a 16 years old patient. Epstein-Barr infection was diagnosed according to serologic evidences. Parkinson-like syndrome completely recovered after 60 days. Autoantibodies reacting against a 130 Kda antigens expressed in human neuroblastoma cell line were detected. Pathogenesis and differential diagnosis are briefly discussed. EBV testing could be worthwhile in juvenile, acute-onset, parkinsonism.
Roselli
Francesco
F
Department of Neurologic and Psychiatric Sciences-University of Bari, p.za Giulio Cesare, 2 70124 Bari (BA), Italy. francesco_roselli@yahoo.it
Russo
Ilenia
I
Fraddosio
Angela
A
Aniello
Maria Stella
MS
De Mari
Michele
M
Lamberti
Paolo
P
Livrea
Paolo
P
Defazio
Giovanni
G
D000208:Acute Disease; D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D018792:Encephalitis, Viral / Q000276:immunology*; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000276:immunology; D009474:Neurons / Q000276:immunology*; D020734:Parkinsonian Disorders / Q000150:complications* / Q000276:immunology*
D000998:Antiviral Agents; D001323:Autoantibodies; D000212:Acyclovir