[Local anaesthetics: what can the pure S enantiomers contribute?].
The use of levobupivacaine and of ropivacaine may increase the safety of regional anaesthesia. These pure enantiomers have similar pharmacokinetic properties as those of the racemic mixtures. However, they are less cardiotoxic than the racemic mixtures, especially at the high heart rate usually encountered in infants. We may then recommend the use of these agents in the paediatric patients.
Mazoit
J-X
JX
Département d'anesthésie et laboratoire d'anesthésie UPRES EA3540, faculté de médecine de Bicêtre, hôpital de Bicêtre 94276 Bicêtre, Le Kremlin-Bicêtre cedex, France. jean-xavier.mazoit@kb.u-psud.fr
Baujard
C
C
D000367:Age Factors; D000577:Amides / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D000779:Anesthetics, Local / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D001798:Blood Proteins / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D002045:Bupivacaine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D000077554:Levobupivacaine; D008657:Metabolic Clearance Rate; D000077212:Ropivacaine; D013237:Stereoisomerism
D000577:Amides; D000779:Anesthetics, Local; D001798:Blood Proteins; D000077212:Ropivacaine; D000077554:Levobupivacaine; D002045:Bupivacaine