title: Overactive bladder: a better understanding of pathophysiology, diagnosis and management.
abstract: OBJECTIVE
  We reviewed current information regarding the updated definitions, prevalence, etiologies, disease burden, and management of OAB from a number of perspectives, including professional impact and patient quality of life.
  
  
  METHODS
  Published literature and current treatment concepts were reviewed regarding the understanding and management of OAB.
  
  
  RESULTS
  OAB is a symptom syndrome including urinary urgency with or without urinary incontinence, usually with frequency and nocturia. Approximately 17% of the adult population experience OAB. There are evolving theories regarding its pathophysiology and the mechanism of action of the most commonly prescribed pharmacological therapy (antimuscarinic agents). Treatment primarily revolves around improving quality of life.
  
  
  CONCLUSIONS
  Behavioral therapy combined with pharmacological therapy often will bring about acceptable outcomes for patients with OAB. Modalities such as botulinum toxin injections, neuromodulation, and various surgical interventions also are showing encouraging results in more refractory patients.
authors.affiliation: University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA. alan.wein@uphs.upenn.edu
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Wein
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Rackley
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001521:Behavior Therapy / Q000379:methods; D004502:Education, Medical, Continuing; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D011379:Prognosis; D011788:Quality of Life; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics; D013520:Urologic Surgical Procedures / Q000379:methods
chemical_list: D018727:Muscarinic Antagonists