title: A mixed factors model for dimension reduction and extraction of a group structure in gene expression data.
abstract: When we cluster tissue samples on the basis of genes, the number of observations to be grouped is much smaller than the dimension of feature vector. In such a case, the applicability of conventional model-based clustering is limited since the high dimensionality of feature vector leads to overfitting during the density estimation process. To overcome such difficulty, we attempt a methodological extension of the factor analysis. Our approach enables us not only to prevent from the occurrence of overfitting, but also to handle the issues of clustering, data compression and extracting a set of genes to be relevant to explain the group structure. The potential usefulness are demonstrated with the application to the leukemia dataset.
authors.affiliation: The Graduate University for Advanced Studies, Minato-ku, Tokyo, Japan. yoshidar@ism.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Yoshida
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Higuchi
authors.forename: Seiya
authors.initials: S
authors.lastname: Imoto
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D003198:Computer Simulation; D005163:Factor Analysis, Statistical; D015870:Gene Expression / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D008957:Models, Genetic; D015233:Models, Statistical; D005810:Multigene Family / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*