A cat with acute myeloblastic leukemia without maturation (M1) treated with combination chemotherapy.
A 2-year-old domestic shorthair cat was presented to us with decreased activity and anorexia. Hematologic findings revealed a mild non-regenerative anemia, thrombocytopenia, and leukocytosis with an increase in blast cells. Bone marrow aspirates also revealed a marked increase of blasts. The blastic cells were shown to be positive for peroxidase. Acute myeloblastic leukemia without maturation (M1) was diagnosed according to the FAB classification. Chemotherapy was initiated with cyclophosphamide, vincristine, prednisolone, and cytosine arabinoside. The cat responded partially. In total, the cats were given 7 blood transfusions. The cat died 14 weeks after first being presented to us.
Mashita
Tadahisa
T
Maizuru Animal Medical Center, Maizuru City, Kyoto 625-0036, Japan.
Shimoda
Tetsuya
T
Yoshioka
Hisao
H
Takahashi
Yasushi
Y
Mitsuda
Masashi
M
D000818:Animals; D001803:Blood Transfusion / Q000662:veterinary; D001854:Bone Marrow Cells / Q000201:enzymology / Q000473:pathology; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003520:Cyclophosphamide / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000662:veterinary*; D009195:Peroxidase / Q000378:metabolism; D011239:Prednisolone / Q000627:therapeutic use*; D014750:Vincristine / Q000627:therapeutic use*
D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone; D009195:Peroxidase