The hematopoietic system: a new niche for the renin-angiotensin system.
The role of the renin-angiotensin system was previously thought to be restricted to the cardiovascular system. It now appears that this system also has important functions in other tissues. Hematopoiesis can be affected by inhibitors of the renin system in patients and in various experimental models. The renin system, particularly angiotensin II, has a role in different stages of hematopoiesis, notably during the first wave in the chick embryo (primitive hematopoiesis) and in the human adult (definitive hematopoiesis). In addition, the renin-angiotensin system in mice is involved in reconstitutive hematopoiesis following experimental irradiation; inhibition of this system improved the hematopoietic recovery in this situation. The clinical relevance and therapeutic applications of these findings offer a new area of clinical research. In this article, we review the evidence for a role for the renin system in the control of hematopoiesis at its different stages.
Hubert
Christine
C
Collège de France, Paris.
Savary
Katia
K
Gasc
Jean-Marie
JM
Corvol
Pierre
P
D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000809:Angiotensins / Q000502:physiology; D000818:Animals; D002642:Chick Embryo; D004921:Erythropoietin / Q000096:biosynthesis; D006410:Hematopoiesis / Q000502:physiology; D006413:Hematopoietic System / Q000502:physiology*; D006801:Humans; D051379:Mice; D009842:Oligopeptides / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins; D009842:Oligopeptides; D004921:Erythropoietin; C058504:goralatide