title: Bedside monitoring of CBF with xenon-CT and a mobile scanner: a novel method in neurointensive care.
abstract: Combining previously independently established techniques our objective was to develop and evaluate a method for bedside qualitative assessment of cerebral blood flow in neurointensive care (NICU) patients. The CT-protocol was optimized using phantoms and comparing a mobile CT-scanner (Tomoscan-M, Philips) with two stationary CT scanners. Thirty-two per cent xenon was delivered with standard equipment (Enhancer 3000). Mean cortical flow in volunteers was 48 ml/min/100 g, with the mean vascular territorial flow varying between 45 and 66 ml/min/100 g. The potential clinical usefulness was illustrated in three patients with vasospasm following subarachnoid haemorrhage. Our conclusion is that quantitative bedside measurements of CBF can be repeatedly performed in an easy and safe way in a standard NICU-setting, using xenon-inhalation and a mobile CT-scanner. The method is useful for the decision-making, and is a good example of how the quality of multi-modality monitoring in the NICU can be developed and further diversified.
authors.affiliation: Department of Neurosurgery, University Hospital, Linköping, Sweden. jan.hillman@lio.se
authors.forename: J
authors.initials: J
authors.lastname: Hillman
authors.forename: P
authors.initials: P
authors.lastname: Sturnegk
authors.forename: H
authors.initials: H
authors.lastname: Yonas
authors.forename: J
authors.initials: J
authors.lastname: Heron
authors.forename: M
authors.initials: M
authors.lastname: Sandborg
authors.forename: T
authors.initials: T
authors.lastname: Gunnarsson
authors.forename: P
authors.initials: P
authors.lastname: Mellergård
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D003422:Critical Care / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D019095:Point-of-Care Systems; D011829:Radiation Dosage; D014057:Tomography, X-Ray Computed / Q000379:methods; D014978:Xenon
chemical_list: D014978:Xenon