The complex between activated protein C and protein C inhibitor: A clinically useful indicator of aortic aneurysms?
The concentration of the complex between activated protein C and the protein C inhibitor reflects the degree of activation of blood coagulation. A sandwich method has been devised that measures the complex concentration in blood plasma. A key feature of the method is that the catching monoclonal antibody recognizes a complex-dependent neoepitope in PCI, which is a prerequisite, since the concentration of uncomplexed PCI is approximately 10(4)-fold higher than that of the complex. In patients with atherosclerotic disease, those with aortic aneurysms exhibit a three-fold increase in complex concentration compared to that of normal subjects.
Stenflo
J
J
Department of Clinical Chemistry, Lund University, University Hospital, Malmö, S205 02 Malmö, Sweden. Johan.Stenflo@klkemi.mas.lu.se
Kjellberg
M
M
Strandberg
K
K
Svensson
P J
PJ
Kölbel
T
T
Lindblad
B
B
D001014:Aortic Aneurysm / Q000175:diagnosis*; D015415:Biomarkers; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D046912:Multiprotein Complexes / Q000032:analysis*; D011486:Protein C / Q000378:metabolism*; D018046:Protein C Inhibitor / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
D015415:Biomarkers; D046912:Multiprotein Complexes; D011486:Protein C; D018046:Protein C Inhibitor