title: Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
abstract: The marine alkaloid variolin B 2 and eight synthetic derivatives with different substituents at positions C-5 and C-7 have been tested in a panel of sixteen human tumor cell lines to evaluate their cytotoxic potential.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 30100-Murcia, Spain. fresnada@um.es
authors.forename: Pilar M
authors.initials: PM
authors.lastname: Fresneda
authors.forename: Santiago
authors.initials: S
authors.lastname: Delgado
authors.forename: Andrés
authors.initials: A
authors.lastname: Francesch
authors.forename: Ignacio
authors.initials: I
authors.lastname: Manzanares
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
authors.forename: Pedro
authors.initials: P
authors.lastname: Molina
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D011161:Porifera / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D001372:Aza Compounds; D006146:Guanidines; D011743:Pyrimidines; C474921:variolin B