title: Quercitrin: an antileishmanial flavonoid glycoside from Kalanchoe pinnata.
abstract: Quercitrin (quercetin 3- O-alpha- L-rhamnopyranoside), one of the constituents of the biologically active aqueous extract obtained from Kalanchoe pinnata, is demonstrated to be a potent antileishmanial compound (IC50 approximately 1 microg/mL) with a low toxicity profile. This is the first time that antileishmanial activity is demonstrated for a flavonoid glycoside.
authors.affiliation: Núcleo de Pesquisas de Produtos Naturais, , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Michelle F
authors.initials: MF
authors.lastname: Muzitano
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Cruz
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: de Almeida
authors.forename: Silvia A G
authors.initials: SA
authors.lastname: Da Silva
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Kaiser
authors.forename: Catherine
authors.initials: C
authors.lastname: Guette
authors.forename: Bartira
authors.initials: B
authors.lastname: Rossi-Bergmann
authors.forename: Sônia S
authors.initials: SS
authors.lastname: Costa
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D031962:Kalanchoe / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000977:Antiparasitic Agents; D010936:Plant Extracts; C012526:quercitrin; D011794:Quercetin