title: Genital Paget's disease in a man.
abstract: Pagetoid cells are large intraepidermal cells which spread intraepidermally. We report a 67-year old Caucasian male, who presented for the first time in 1993 with a long-standing pruritic lesion at the scrotum. He was treated for several years by antiinflammatory ointments. Only in July 2003 was a biopsy taken for the first time. The histopathological evaluation revealed the diagnosis of an extramammary Paget's disease (EMPD). Pagetoid cells are large intraepidermal cells with a large nucleus and ample cytoplasm. EMPD consists of primary malignant cells of epidermal origin, but in rare cases, pagetoid cells may also originate from carcinomas with epidermotropic growth. EMPD is a slowly progressing disease, but invading and metastasing tumors may also develop. Considering the good prognosis with long-term survival, nonsurgical modalities should be considered as primary treatment for noninvasive EMPD.
authors.affiliation: Department of Andrology and Venerology, University Hospital, Philipp University, Deutschhausstr. 9, D-35033 Marburg, Germany. krause@med.uni-marburg.de
authors.forename: Walter
authors.initials: W
authors.lastname: Krause
authors.forename: Andreas
authors.initials: A
authors.lastname: Krisp
authors.forename: Stefan
authors.initials: S
authors.lastname: Hörster
authors.forename: Rolf
authors.initials: R
authors.lastname: Hoffmann
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D011537:Pruritus / Q000175:diagnosis; D012611:Scrotum; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones