Development and regulation of dendritic spine synapses.
Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and plasticity. Recent advances in imaging and molecular technologies reveal that spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Several neurological and psychiatric disorders exhibit dendritic spine abnormalities.
Calabrese
Barbara
B
Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California, USA.
Wilson
Margaret S
MS
Halpain
Shelley
S
D000818:Animals; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D049229:Dendritic Spines / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009473:Neuronal Plasticity; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure; D009435:Synaptic Transmission; D020741:rho GTP-Binding Proteins / Q000502:physiology
D020741:rho GTP-Binding Proteins