Furoxan derivatives as cytotoxic agents: preliminary in vivo antitumoral activity studies.
Furoxan derivatives with in vitro cytotoxic activity were investigated as antitumoral agents in vivo. The compounds were tested in murine models of both CCRFS-180 II sarcoma and mammary adenocarcinoma. Two of the furoxan derivatives considered here, 3-formyl-4-phenyl-1,2,5-oxadiazole N2-oxide and 3-carbonitrile-4-phenyl-1,2,5-oxadiazole N2-oxide, present in vivo antitumoral activity. They were able to produce more than 90% of tumoral necrosis under the experimental protocol of administration and posology employed. NO-releasing capacity of furoxans may explain the anti-neoplastic activity of these compounds.
Aguirre
G
G
Departamento de Química Orgánica, Facultad de Química y Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Boiani
M
M
Cerecetto
H
H
Fernández
M
M
González
M
M
León
E
E
Pintos
C
C
Raymondo
S
S
Arredondo
C
C
Pacheco
J P
JP
Basombrío
M A
MA
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D011810:Quinoxalines / Q000494:pharmacology; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology
D000970:Antineoplastic Agents; D010069:Oxadiazoles; D011810:Quinoxalines; C010166:furoxans; C003282:quindoxin