title: Parvovirus B19-induced anemia in renal transplantation: a role for rHuEPO in resistance to classical treatment.
abstract: Human parvovirus B19 (PVB 19) is responsible for pure red cell aplasia in immunocompromised patients, and particularly solid organ recipients. Intravenous immunoglobulins (IVIG) have been shown to be efficient to achieve the correction of anemia in association with the reduction of immunosuppression. We report a case of kidney transplant recipient with PVB 19-induced anemia that did not respond to recombinant human erythropoietin (rHuEPO) and to a first course of IVIG. After discontinuation of rHuEPO, a second course of IVIG was successful with the resolution of anemia. We discuss the role of rHuEPO that may facilitate PVB 19 replication in erythropoietin-sensitive human erythroid progenitor cells.
authors.affiliation: Nephrology Unit, Bicetre Hospital, Le Kremlin Bicetre France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Arzouk
authors.forename: Renaud
authors.initials: R
authors.lastname: Snanoudj
authors.forename: Anne
authors.initials: A
authors.lastname: Beauchamp-Nicoud
authors.forename: Georges
authors.initials: G
authors.lastname: Mourad
authors.forename: Bernard
authors.initials: B
authors.lastname: Charpentier
authors.forename: Gil
authors.initials: G
authors.lastname: Tchernia
authors.forename: Antoine
authors.initials: A
authors.lastname: Durrbach
mesh_terms: D004351:Drug Resistance; D004921:Erythropoietin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications / Q000821:virology; D016732:Parvovirus B19, Human / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D011994:Recombinant Proteins; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000628:therapy / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D016756:Immunoglobulins, Intravenous; D011994:Recombinant Proteins; D004921:Erythropoietin