Parathyroid carcinoma in a chronic hemodialysis patient: case report and review of the literature.
Parathyroid carcinoma is a rare disease in normal population as well as in patients with end-stage renal disease. Approximately 700 cases have been reported and, of these, 20 occurred in patients receiving chronic hemodialysis. We describe a case of parathyroid carcinoma in a 59-year-old female patient with end-stage renal disease secondary to membranous glomerulonephritis treated by hemodialysis since 1995. In September 1998, the calcium level was 12.4 mg/dl and intact parathyroid hormone serum levels were 1366 pg/ml (normal range, 25-65). A routine ultrasonographic examination of the neck revealed enlargement of two parathyroid glands, the left inferior gland being the largest and measuring 2x3x2 cm. In October 1998, resection of two parathyroid glands was performed. On the basis of histology, which documented the presence of proliferating cells arranged in sheets or in a trabecular pattern, numerous mitosis and vascular invasion, a diagnosis of parathyroid carcinoma was made.
Bossola
Maurizio
M
Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo Gemelli 8, 00168 Rome, Italy. maubosso@tin.it
Tazza
Luigi
L
Ferrante
Angela
A
Giungi
Stefania
S
Carbone
Arnaldo
A
Gui
Daniele
D
Luciani
Giovanna
G
D002118:Calcium / Q000097:blood; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006435:Renal Dialysis
D010281:Parathyroid Hormone; D002118:Calcium