In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains.
The antimicrobial activity of human beta-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.
Maisetta
Giuseppantonio
G
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy.
Batoni
Giovanna
G
Esin
Semih
S
Florio
Walter
W
Bottai
Daria
D
Favilli
Flavia
F
Campa
Mario
M
D001419:Bacteria / Q000187:drug effects*; D003428:Cross Infection / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D044967:Serum / Q000502:physiology; D023083:beta-Defensins / Q000494:pharmacology*
C422950:DEFB103A protein, human; D023083:beta-Defensins