Genetic imprinting analysis for alcoholism genes using variance components approach.
Genomic imprinting, which is also known as the parent-of-origin effect, is a mechanism that only expresses one copy of a gene pair depending upon the parental origin. Although many chromosomal regions in the human genome are likely to be imprinted, imprinting is not accounted for in the usual linkage analysis. In this study, using a variance-components approach with a quantitative phenotype ttth-FP1, we found significant evidence of imprinting at two loci, D7S1790 and D1S1631, on chromosome 1 and chromosome 7, respectively. Our results suggest that allowing for the possibility of imprinting can increase the power to detect linkage for localizing genes for alcoholism.
Shete
Sanjay
S
Department of Epidemiology, Unit 1340, University of Texas M. D. Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA. sshete@mdanderson.org
Yu
Robert
R
D000437:Alcoholism / Q000235:genetics*; D000704:Analysis of Variance; D008040:Genetic Linkage; D018392:Genomic Imprinting; D006801:Humans; D016013:Likelihood Functions; D010641:Phenotype