Metal complexes in medicinal chemistry: new vistas and challenges in drug design.
An overview is presented of selected metal-based pharmaceuticals, either diagnostic or therapeutic, with emphasis on specific attributes and in vivo interactions of these compounds relevant to their use in medicinal applications. Both the advantages and the challenges of this approach are outlined, with possibilities for future developments accentuated.
Thompson
Katherine H
KH
Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
Orvig
Chris
C
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D017076:Computer-Aided Design; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D007287:Inorganic Chemicals; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013329:Structure-Activity Relationship
D007287:Inorganic Chemicals; D008024:Ligands; D004364:Pharmaceutical Preparations