title: Serum cholinesterase activity and proteosynthetic function of liver in patients with diabetes mellitus.
abstract: BACKGROUND
  Diabetes mellitus is associated with a lot of changes in intermediary metabolism and several authors reported on higher frequency of liver diseases in patients with diabetes.
  
  
  OBJECTIVE
  Was to establish the changes of blood serum cholinesterase, prealbumin and albumin, parameters which are accepted as an index of liver proteosynthetic function, in patients with diabetes mellitus.
  
  
  METHODS
  The study group consisted of 207 patients with diabetes mellitus (83 patients with type I and 124 patients with type II diabetes mellitus). Control group consisted of 179 healthy subjects. The activity of cholinesterase was assayed by the kinetic method, concentrations of prealbumin and albumin were determined immunochemically.
  
  
  RESULTS
  Activity of serum cholinesterase was significantly higher in group of patients with diabetes mellitus than in control group (65.05 vs 73.33 microkat/l). The concentration of prealbumin was lower in blood serum of patients with diabetes than in controls (308.10 vs 285.85 mg/l). Serum levels of albumin were not different in both studied groups. After dividing of patients according to the type of diabetes, 80 % of abnormal values of cholinesterase and prealbumin were present in patients with type II diabetes.
  
  
  CONCLUSIONS
  The results of our study showed abnormal values of determined liver tests approximately in 22 % of patients with diabetes mellitus. The character of laboratory changes--increased activity of cholinesterase, decreased concentration of prealbumin and normal levels of albumin, suggests development of liver steatosis in these patients. The most of pathological findings were in patients with diabetes type II (Tab. 3, Ref. 20).
authors.affiliation: Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Bratislava, Slovakia. laco.t@seznam.cz
authors.forename: L
authors.initials: L
authors.lastname: Turecky
authors.forename: V
authors.initials: V
authors.lastname: Kupcova
authors.forename: V
authors.initials: V
authors.lastname: Mojto
authors.forename: M
authors.initials: M
authors.lastname: Smutny
authors.forename: E
authors.initials: E
authors.lastname: Uhlikova
authors.forename: I
authors.initials: I
authors.lastname: Vozar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002802:Cholinesterases / Q000097:blood*; D003920:Diabetes Mellitus / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008875:Middle Aged; D011228:Prealbumin / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis
chemical_list: D011228:Prealbumin; D012709:Serum Albumin; D002802:Cholinesterases