Self-assembly and characterization of layered double hydroxide/DNA hybrids.
The purpose of this study was to control the fabrication of new labile supramolecular assemblies by formulating associations of DNA molecules with inorganic layered double hydroxides (LDHs). The results show that LDH/DNA hybrids synthesized by a coprecipitation route involving the in situ formation of LDHs around DNA molecules acting as templates were characterized by a lamellar organization, with DNA molecules sandwiched between hydroxide layers, exhibiting a regular spacing of 1.96 nm. Our results indicate that labile complexes resulting from the association of nucleic acids and inorganic materials can be obtained not only by anion exchange but also by a direct self-assembly route.
Desigaux
Léa
L
Inserm U533, Faculté de Médecine, 1 rue Gaston Veil, 44000 Nantes, France.
Belkacem
Malha Ben
MB
Richard
Peggy
P
Cellier
Joël
J
Léone
Philippe
P
Cario
Laurent
L
Leroux
Fabrice
F
Taviot-Guého
Christine
C
Pitard
Bruno
B
D004247:DNA / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D033362:Powder Diffraction; D012680:Sensitivity and Specificity; D013499:Surface Properties
D006878:Hydroxides; D004247:DNA