title: Neuronal electrical rhythms described by composite mapped clock oscillators.
abstract: The Mapped Clock Oscillator (MCO) model is a representation of omnipresent transmembrane voltage oscillations in excitable cells. We present a generalized version of the MCO that can model neuronal electrical oscillations, both labile and omnipresent, entirely within the framework of a system of ordinary differential equations. The previously described MCO was a second-order system, whereas the model presented here, which we call the composite MCO (cMCO) is a fourth-order system. Furthermore, we show how this cMCO can also be adapted to describe a pair of cells that forms a functional unit, as illustrated here by a model of the CA3 pyramidal cell and its basket cell interneuron feedback loop. The model was able to reproduce the high frequencies (super gamma) and possibly chaotic dynamics observed in the biological system.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, Department of Electrical and Computer Engineering, University of Toronto, 4 Taddle Creek Road, Room 407, Rosebrugh Building, Toronto, Ontario, Canada, M5S 3G9.
authors.forename: José
authors.initials: J
authors.lastname: Zariffa
authors.forename: Berj L
authors.initials: BL
authors.lastname: Bardakjian
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D017966:Pyramidal Cells / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*