title: Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice.
abstract: Aerial parts of Swertia longifolia Boiss. (Gentianaceae), which grows in the north of Iran, were screened for hepatoprotective activity against paracetamol (acetaminophen)-induced hepatotoxicity in Swiss mice. Pretreatment with total plant extract and swerchirin, the major component of the plant, significantly reduced the elevation of biochemical parameters, AST (aspartate aminotransferase), ALT (alanine aminotransferase) and ALP (alkaline phosphatase), the enzymes that are increased by liver damage (P < 0.001). Our results indicated that total plant extract and swerchirin were hepatoprotective in the range of 6-50 mg kg(-1) orally.
authors.affiliation: Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Homa
authors.initials: H
authors.lastname: Hajimehdipoor
authors.forename: Zhina
authors.initials: Z
authors.lastname: Sadeghi
authors.forename: Sara
authors.initials: S
authors.lastname: Elmi
authors.forename: Azadeh
authors.initials: A
authors.lastname: Elmi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ghazi-Khansari
authors.forename: Yaghoub
authors.initials: Y
authors.lastname: Amanzadeh
authors.forename: Seyyed-Esmaeal
authors.initials: SE
authors.lastname: Sadat-Ebrahimi
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000633:toxicity; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology*; D029967:Swertia / Q000737:chemistry*; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D020011:Protective Agents; D044004:Xanthones; D000082:Acetaminophen; C034385:swerchirin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase