Influence of HBcAg in liver cell plasma on expression of transforming growth factor-beta 1 in liver tissue of low-grade chronic hepatitis B patients.
OBJECTIVE
To study the influence of HBcAg on the expression of transforming growth factor-beta 1 (TGF-beta1) in liver tissue of low-grade chronic hepatitis B (CHB) patients.


METHODS
The expression of TGF-beta1 and HBcAg in liver samples from 93 low-grade CHB patients was detected by immunohistochemistry and valuated by semi-quantitative scoring.


RESULTS
In the 93 low-grade CHB patients, HBcAg was expressed in cell plasma but not in the liver tissue. There was no significant difference between the two groups.


CONCLUSIONS
The expression of TGF-beta1 is not related with HBcAg expressed as plasma type in the tissues of low-grade CHB patients.
Liu
Yong-Gang
YG
Department of Clinical Hepatitis, Tianjin Infectious Disease Hospital, Tianjin 300192, China. ygwx@public.tpt.tj.cn
Lu
Jian-Hua
JH
Wang
Xin-Xin
XX
Yang
Jian-Lin
JL
Lang
Zhen-Wei
ZW
Meng
Xin
X
Zhang
Li-Jie
LJ
Sun
Lin
L
Zhang
Shi-Jie
SJ
Li
Jun-Qiang
JQ
Song
Chen-Zhao
CZ
D000293:Adolescent; D000328:Adult; D005260:Female; D006512:Hepatitis B Core Antigens / Q000032:analysis*; D019698:Hepatitis C, Chronic / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000032:analysis*; D053773:Transforming Growth Factor beta1
D006512:Hepatitis B Core Antigens; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1