Nervous activity in a stem cell niche.
In this issue of Cell, report a new regulatory axis for the mobilization of hematopoietic stem cells that links these cells to the nervous system and bone in an unanticipated way. The new findings suggest that the nervous system, which has the inherent ability to integrate information from throughout the organism, may govern the local relationship between stem cells and their niches.
Larsson
Jonas
J
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, 02114, USA.
Scadden
David
D
D000818:Animals; D001842:Bone and Bones / Q000294:innervation* / Q000502:physiology*; D002465:Cell Movement; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D010006:Osteoblasts / Q000502:physiology; D015398:Signal Transduction; D013564:Sympathetic Nervous System / Q000502:physiology*
D016179:Granulocyte Colony-Stimulating Factor