title: Directed DNA metallization.
abstract: Genes of interest can be selectively metallized via the incorporation of modified triphosphates. These triphosphates bear functions that can be further derivatized with aldehyde groups via the use of click chemistry. Treatment of the aldehyde-labeled gene mixture with the Tollens reagent, followed by a development process, results in the selective metallization of the gene of interest in the presence of natural DNA strands.
authors.affiliation: Department of Chemistry, Technion, Haifa, Israel.
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Burley
authors.forename: Johannes
authors.initials: J
authors.lastname: Gierlich
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Mofid
authors.forename: Hadar
authors.initials: H
authors.lastname: Nir
authors.forename: Shay
authors.initials: S
authors.lastname: Tal
authors.forename: Yoav
authors.initials: Y
authors.lastname: Eichen
authors.forename: Thomas
authors.initials: T
authors.lastname: Carell
mesh_terms: D018076:DNA, Complementary / Q000737:chemistry*; D004271:DNA, Fungal / Q000737:chemistry; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry; D006801:Humans; D016133:Polymerase Chain Reaction; D012834:Silver / Q000737:chemistry*; D000099270:Y-Family DNA Polymerases
chemical_list: D018076:DNA, Complementary; D004271:DNA, Fungal; D004259:DNA-Directed DNA Polymerase; D012834:Silver; C112338:Rad30 protein; D000099270:Y-Family DNA Polymerases