title: Factor VIIa inhibitors: improved pharmacokinetic parameters.
abstract: Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.
authors.affiliation: Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. kolesnikov@yahoo.com
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Kolesnikov
authors.forename: Roopa
authors.initials: R
authors.lastname: Rai
authors.forename: Wendy B
authors.initials: WB
authors.lastname: Young
authors.forename: Joyce
authors.initials: J
authors.lastname: Mordenti
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Steven
authors.initials: S
authors.lastname: Torkelson
authors.forename: William D
authors.initials: WD
authors.lastname: Shrader
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Leahy
authors.forename: Huiyong
authors.initials: H
authors.lastname: Hu
authors.forename: Erik
authors.initials: E
authors.lastname: Gjerstad
authors.forename: James
authors.initials: J
authors.lastname: Janc
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Katz
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sprengeler
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000493:pharmacokinetics*; D001777:Blood Coagulation / Q000187:drug effects*; D015195:Drug Design; D015942:Factor VIIa / Q000037:antagonists & inhibitors*; D006207:Half-Life; D006801:Humans; D015394:Molecular Structure; D015842:Serine Proteinase Inhibitors / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship
chemical_list: D000925:Anticoagulants; D015842:Serine Proteinase Inhibitors; D015942:Factor VIIa