Lipid peroxidative damage on malathion exposure in rats.
Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue in vivo, including the central nervous system (CNS). The aim of this study was to examine whether malathion, a commonly used organophosphorus (OP), might induce oxidative stress in cerebrospinal fluid, blood serum and brain structures in male Wistar rats. Malathion was administered intraperitoneally in the doses of 25, 50, 100 and 150 mg/kg for 28 days. Oxidative damage was determined by measuring the thiobarbituric acid reactive species (TBARS) content, as an index of lipid peroxidation. TBARS concentration in the cerebrospinal fluid (CSF) and brain structures were increased, but a decrease in TBARS concentration in serum was observed. The results of the present study suggest the usefulness of TBARS measurement as a good biomarker in the estimation of malathion-induced oxidative stress affecting CSF and brain structures.
Fortunato
Jucéla J
JJ
Laboratório de Neurociências, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brasil.
Agostinho
Fabiano R
FR
Réus
Gislaine Z
GZ
Petronilho
Fabrícia C
FC
Dal-Pizzol
Felipe
F
Quevedo
João
J
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D015227:Lipid Peroxidation / Q000187:drug effects*; D008294:Malathion / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014018:Tissue Distribution / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D017392:Thiobarbituric Acid Reactive Substances; D008294:Malathion