[Granulosa-stromal tumor of the ovary: a case of mixed germ cell-cord stromal tumor of the ovary with endocrinological considerations].
Granulosa-stromal tumors comprise 5 to 8% of all primary ovarian neoplasms. The first clinical manifestation is precocious puberty in most prepuberal patients. We report a case of mixed germ cell-cord stromal tumor of ovary in a 7.2 years old girl, who presented with isosexual pseudo-precocious puberty of progressive outcome. Serum testosterone, estradiol and 17alphaOH-progesterone levels were increased. Abdominal-pelvic ultrasound revealed a right ovarian mass. Unilateral salpingo-oophorectomy was performed with complete resection of the tumor. The patient is well 7 years after surgery with normal pubertal and growth development and no signs of tumor relapse. We review the clinical manifestations of ovarian tumors, classification and staging of sex cord-stromal tumors, follow-up, tumor markers, treatment and prognosis.
Paula
Leila C P de
LC
Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, RS.
Zen
Vanessa L
VL
Czepielewski
Mauro A
MA
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000601:surgery; D006801:Humans; D018198:Mixed Tumor, Malignant / Q000150:complications* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications* / Q000601:surgery; D010052:Ovariectomy / Q000379:methods; D011629:Puberty, Precocious / Q000209:etiology*; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D013739:Testosterone; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone