title: New surface modification of titanium implant with phospho-amino acid.
abstract: The purpose of this study was to investigate a new biochemical surface modification technique for titanium implants using phospho-amino acid. Pure titanium disks were pretreated with 10 N HCl and ultrapure water at room temperature for 30 minutes respectively. Then these disks were modified with either L-threonine (Thr) or O-phospho-L-threonine (P-Thr) at 37 degrees C for 12 hours. X-ray photoelectron spectroscopy (XPS) chemically analyzed the modified surfaces. It was revealed that the N 1s peak which originated from Thr was not detected in the wide-scan spectrum of Thr-modified surface, whereas three peaks of N 1s, P 2s, and P 2p which originated from P-Thr were detected in the wide-scan spectrum of P-Thr-modified surface. Moreover, the P 2p peak of P-Thr which reacted with the surface significantly shifted to a lower binding energy (p < 0.05). Based on the results of this study, it was concluded that P-Thr chemically bonded to the titanium surface treated with HCl.
authors.affiliation: Department of Advanced Prosthodontics, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Japan. abey@hiroshima-u.ac.jp
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Abe
authors.forename: Kyou
authors.initials: K
authors.lastname: Hiasa
authors.forename: Maho
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Akagawa
mesh_terms: D001840:Dental Bonding; D015921:Dental Implants; D017267:Dental Prosthesis Design; D006851:Hydrochloric Acid; D008422:Materials Testing; D010769:Phosphothreonine; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D014025:Titanium
chemical_list: D015921:Dental Implants; D010769:Phosphothreonine; D014025:Titanium; D006851:Hydrochloric Acid