title: Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechins.
abstract: (-)-Epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg) reduce oxacillin resistance in mecA-containing strains of Staphylococcus aureus. Their binding to staphylococcal cells is enhanced by the nongalloyl analogues (-)-epicatechin (EC) and (-)-epigallocatechin (EGC). EC and EGC significantly increased the capacity of ECg and EGCg to reduce levels of staphylococcal oxacillin resistance.
authors.affiliation: Microbiology Group, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Stapleton
authors.forename: Saroj
authors.initials: S
authors.lastname: Shah
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Peter W
authors.initials: PW
authors.lastname: Taylor
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate; C057580:gallocatechol; D010068:Oxacillin