Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary alkyl halides with aryl Grignard reagents.
Simple catalysts formed in situ from iron chloride and a wide range of monodentate and bidentate phosphines and arsines have been screened in the coupling of alkyl halides bearing beta-hydrogens with aryl Grignard reagents. The best of these show excellent activity, as do catalysts formed in situ with monodentate trialkyl and triaryl phosphite ligands. N-heterocyclic carbene-based precatalysts, either preformed or made in situ, also show excellent performance.
Bedford
Robin B
RB
School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K. r.bedford@bristol.ac.uk
Betham
Michael
M
Bruce
Duncan W
DW
Danopoulos
Andreas A
AA
Frost
Robert M
RM
Hird
Michael
M