title: Fractal genomics modeling: a new approach to genomic analysis and biomarker discovery.
abstract: Reverse engineering of genetics networks generally requires establishing correlative behavior within and between a very large number of genes. This becomes a difficult analytical problem for even a few hundred genes and the difficulty tends to grow exponentially as more genes are examined. Using a hybrid data analysis method known as Fractal Genomics Modeling (FGM), this problem is reduced to examining correlative behavior within small gene groups that can then be compared and integrated to produce a picture of larger networks using a type pf shotgun approach. We have applied FGM toward examining genetic networks involved in HIV infection in the brain. These networks have relevance both to processes related to HIV infection and neurodegenerative disorders. Our preliminary findings have produced conjectures of related pathways and networks as well new candidates for genetic markers in HIV brain infection. Evidence has also been produced which appears to show the presence of a hierarchical network structure within the genes studied. We will discuss the background and methodology of FGM as well as our recent findings.
authors.affiliation: Health Discovery Corporation, Inc., Savannah, GA 31406, USA. sshaw@healthdiscoverycorp.com
authors.forename: Sandy
authors.initials: S
authors.lastname: Shaw
authors.forename: Paul
authors.initials: P
authors.lastname: Shapshak
mesh_terms: D015526:AIDS Dementia Complex / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D003198:Computer Simulation; D017709:Fractals; D020022:Genetic Predisposition to Disease / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D020543:Proteome / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D009419:Nerve Tissue Proteins; D020543:Proteome