On the interaction of vanadium species with meso-2,3-dimercaptosuccinic acid.
The interaction of the VO2+ cation with meso-2,3-dimercaptosuccinic acid (DMSA) was investigated by electron absorption spectroscopy in aqueous solution at different pH values. The spectral behavior, complemented with a spectrophotometric titration, shows the generation of a [VO(DMSA)2]2- complex in which the oxocation interacts with two pairs of deprotonated -SH groups of the acid. It was also found that DMSA rapidly reduces VO3- to VO2+, which might be chelated by an excess of the acid. DMSA can also produce the partial reduction of a V2O5 suspension at pH=5.2. The results of this study suggest that DMSA might be a potentially useful detoxification agent for vanadium.
Williams
P A M
PA
Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C. Correo 962, 1900-La Plata, Argentina.
Baran
E J
EJ
D002614:Chelating Agents; D004347:Drug Interactions; D008658:Inactivation, Metabolic; D010084:Oxidation-Reduction; D046590:Spectroscopy, Electron Energy-Loss; D004113:Succimer / Q000378:metabolism*; D014638:Vanadates / Q000378:metabolism; D014639:Vanadium / Q000378:metabolism*
D002614:Chelating Agents; D014639:Vanadium; C075743:oxovanadium IV; D014638:Vanadates; D004113:Succimer