Utilization of the pleiotropy of a peptidic aptamer to fabricate heterogeneous nanodot-containing multilayer nanostructures.
Peptide aptamers (=binders) against inorganic materials often show a capacity for mineralization of their target atoms; thus they are able to function both as binding molecules and as mediators for mineralization. Although the mechanisms underlying these two properties of peptide aptamers are not yet fully understood, they have been used separately to fabricate various nanostructures. Here, we present a novel method of nanofabrication, in which binding and mineralization by a peptide aptamer are alternately utilized to assemble multilayered nanostructures comprised of metal loaded cage proteins ornamented with Ti-binding peptides.
Sano
Ken-Ichi
K
Department of Protein Engineering, Cancer Institute, Japanese Foundation for Cancer Research and CREST, JST, Koto, Tokyo 135-8550, Japan.
Sasaki
Hiroyuki
H
Shiba
Kiyotaka
K
D000595:Amino Acid Sequence; D052158:Aptamers, Peptide / Q000138:chemical synthesis / Q000737:chemistry*; D005293:Ferritins / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry
D052158:Aptamers, Peptide; D009842:Oligopeptides; D012822:Silicon Dioxide; D005293:Ferritins