title: Neonatal eosinophilic pustulosis.
abstract: A pre-term, 7-week-old male infant presented with a recurrent pustular eruption involving his face and scalp with associated peripheral blood eosinophilia. Skin biopsy revealed spongiosis with numerous dermal and epidermal eosinophils without predominant follicular involvement. Immunohistology showed deposition of eosinophil granule major basic protein and eosinophil derived neurotoxin in the dermis and epidermis. He responded to conservative management. We discuss the differential diagnosis of neonatal eosinophilic pustular eruptions and suggest the term 'neonatal eosinophilic pustulosis' to best describe our case.
authors.affiliation: Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195-6524, USA.
authors.forename: Maryam
authors.initials: M
authors.lastname: Asgari
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Leiferman
authors.forename: Michael
authors.initials: M
authors.lastname: Piepkorn
authors.forename: Melanie K
authors.initials: MK
authors.lastname: Kuechle
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001458:Bandages; D001706:Biopsy; D047093:Eosinophil Major Basic Protein / Q000032:analysis; D047208:Eosinophil-Derived Neurotoxin / Q000032:analysis; D004802:Eosinophilia / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D016712:Mupirocin / Q000627:therapeutic use; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000628:therapy; D012965:Sodium Chloride / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D012965:Sodium Chloride; D016712:Mupirocin; D047208:Eosinophil-Derived Neurotoxin; D047093:Eosinophil Major Basic Protein