Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis.
Although various animal models have been developed to clarify gastric carcinogenesis, apparent mechanism of gastric cancer was not clarified in recent years. Since the recognition of the pathogenicity of Helicobacter pylori (H pylori), several animal models with H pylori infection have been developed to confirm the association between H pylori and gastric cancer. Nonhuman primate and rodent models were suitable for this study. Japanese monkey model revealed atrophic gastritis and p53 mutation after long-term infection of H pylori. Mongolian gerbil model showed the development of gastric carcinoma with H pylori infection alone, as well as with combination of chemical carcinogens, such as N-methyl-N-nitrosourea and N-methyl-N-nitro-N'-nitrosoguanidine. The histopathological changes of these animal models after H pylori inoculation are closely similar to those in human beings with H pylori infection. Eradication therapy attenuated the development of gastric cancer in H pylori-infected Mongolian gerbil. Although several features of animal models differ from those seen in human beings, these experimental models provide a starting point for further studies to clarify the mechanism of gastric carcinogenesis as a result of H pylori infection and assist the planning of eradication therapy to prevent gastric carcinoma.
Kodama
Masaaki
M
Department of Gastroenterology, Oita University, Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Oita-gun, Oita 879-55, Japan. kodm@med.oita-u.ac.jp
Murakami
Kazunari
K
Sato
Ryugo
R
Okimoto
Tadayoshi
T
Nishizono
Akira
A
Fujioka
Toshio
T
D000818:Animals; D004195:Disease Models, Animal; D005756:Gastritis / Q000150:complications* / Q000473:pathology; D016158:Genes, p53; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008251:Macaca; D051379:Mice; D051381:Rats; D013045:Species Specificity; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control