title: Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.
abstract: The nortropane cocaine analogue, 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane (ZIENT), is a high affinity, selective serotonin transporter (SERT) ligand that has shown promise as a SERT imaging agent for single photon computed tomography (SPECT) when labeled with I-123. Synthesis of the labeling precursor, radiosynthesis of [(11)C]ZIENT, and in vivo evaluation in anesthetized and awake monkeys have been performed to determine the suitability of [(11)C]ZIENT as a PET agent for SERT imaging.
authors.affiliation: Department of Radiology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Plisson
authors.forename: Nachwa
authors.initials: N
authors.lastname: Jarkas
authors.forename: Jon
authors.initials: J
authors.lastname: McConathy
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Voll
authors.forename: John
authors.initials: J
authors.lastname: Votaw
authors.forename: Larry
authors.initials: L
authors.lastname: Williams
authors.forename: Leonard L
authors.initials: LL
authors.lastname: Howell
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Kilts
authors.forename: Mark M
authors.initials: MM
authors.lastname: Goodman
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002250:Carbon Radioisotopes; D007553:Isotope Labeling; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D009662:Nortropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
chemical_list: C472792:2-carbomethoxy-3-(4'-(2-iodoethenyl)phenyl)nortropane; D002250:Carbon Radioisotopes; D009662:Nortropanes; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins