title: Supplemental 80% oxygen does not attenuate post-operative nausea and vomiting after breast surgery.
abstract: BACKGROUND
  Although supplemental oxygen has been shown to be as effective as ondansetron in the prevention of post-operative nausea and vomiting (PONV) in one study in abdominal surgery patients, the antiemetic efficacy of supplemental oxygen is controversial on the basis of studies with other patients. We compared the efficacy of 80% and 30% oxygen in decreasing PONV in breast surgery. Ondansetron was used as an active control.
  
  
  METHODS
  Ninety patients were given a standardized sevoflurane anesthetic. They were randomly assigned to three groups: 30% oxygen in nitrogen and saline 2 ml intravenously (i.v.) at the end of surgery (group 30); 80% oxygen in nitrogen and saline 2 ml (group 80); and 30% oxygen in nitrogen and ondansetron 4 mg (group O). Oxygen was administered during surgery and up to 2 h after surgery.
  
  
  RESULTS
  The incidence of total response (no retching or vomiting, no nausea) during the first 24 post-operative hours was not different between group 80 (17%) and group 30 (11%) but was higher in group O (43%) than in group 30 (P<0.05). Compared with group O, patients in group 80 experienced more vomiting during the study period 0-24 h (66% vs. 32%; P<0.05) and more nausea during the period 6-24 h (72% vs. 39%; P<0.05). There was no difference between the groups in their risk for PONV, pain scores, opioid consumption, or patient satisfaction.
  
  
  CONCLUSIONS
  In this study, supplemental 80% oxygen administration failed to decrease PONV in breast surgery.
authors.affiliation: Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland. sinikka.purhonen@kuh.fi
authors.forename: S
authors.initials: S
authors.lastname: Purhonen
authors.forename: M
authors.initials: M
authors.lastname: Niskanen
authors.forename: M
authors.initials: M
authors.lastname: Wüstefeld
authors.forename: E
authors.initials: E
authors.lastname: Hirvonen
authors.forename: M
authors.initials: M
authors.lastname: Hynynen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018685:Anesthetics, Inhalation; D000932:Antiemetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008408:Mastectomy; D008738:Methyl Ethers; D008875:Middle Aged; D017294:Ondansetron / Q000627:therapeutic use; D010102:Oxygen Inhalation Therapy; D010149:Postoperative Pain; D017060:Patient Satisfaction; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy / Q000517:prevention & control*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D000932:Antiemetics; D008738:Methyl Ethers; D000077149:Sevoflurane; D017294:Ondansetron