AID in somatic hypermutation and class switch recombination.
Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.
Longerich
Simonne
S
Department of Molecular Genetics and Cell Biology, University of Chicago, 920 E. 58(th) Street, Chicago, IL 60615, USA.
Basu
Uttiya
U
Alt
Frederick
F
Storb
Ursula
U
D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics / Q000276:immunology*; D004247:DNA / Q000276:immunology; D006801:Humans; D017578:Immunoglobulin Class Switching; D007134:Immunoglobulin Switch Region / Q000235:genetics; D018448:Models, Immunological; D011995:Recombination, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D004247:DNA; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase