title: Delayed-onset heparin-induced thrombocytopenia and thrombosis after intraoperative heparin anticoagulation-four case reports.
abstract: Delayed-onset heparin-induced thrombocytopenia (HIT) is a rare and only recently described condition. The authors report 4 cases of delayed-onset HIT, each of which presented with thrombotic complications 8-18 days after receiving heparin for coronary artery bypass grafting. Delayed-onset HIT should be suspected in any patient presenting with arterial or venous thromboembolism after heparin therapy, even 1 to 3 weeks after heparin exposure.
authors.affiliation: Department of Surgery, University of Texas Southwestern Medical Center, Dallas, USA. markjackson@ghs.org
authors.forename: Mark R
authors.initials: MR
authors.lastname: Jackson
authors.forename: William J
authors.initials: WJ
authors.lastname: Neilson
authors.forename: Michael
authors.initials: M
authors.lastname: Lary
authors.forename: Peter
authors.initials: P
authors.lastname: Baay
authors.forename: Kent
authors.initials: K
authors.lastname: Web
authors.forename: G Patrick
authors.initials: GP
authors.lastname: Clagett
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D000075202:Contraindications; D001026:Coronary Artery Bypass / Q000379:methods; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D010976:Platelet Count; D011183:Postoperative Complications; D013921:Thrombocytopenia / Q000209:etiology*; D013923:Thromboembolism / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D006493:Heparin