title: The use of artificial dermis in the treatment of chronic and acute wounds: regeneration of dermis and wound healing.
abstract: Wounds with large loss of deep tissue can be repaired using a dermis substitute. When wounds have an irregular fund, applying a skin graft on these one can be a failure. Integra Dermal Regeneration Template is a bilaminate material, a collagen chondroitin-sponge overlayed with silicone. It heals wounds where conventional methods of repair fail or are too risk. This study analizes Integra's use for chronic and pathological wounds in 7 patients. Applied to wounds reduces inflammation and protects it from a possible contamination or another injury. Imbibition, fibroblast migration, neovascularization, remodeling and maturation are distinct histologic phases of forming neodermis. Trough the silicon layer is possible to observe the histogenesis: the change in color of the matrix is a predictor of its vascularization. When the color has progressed from pink through pale yellow and finally to peach, the neodermis is fully vascolarized. The postoperative care is minimum. Integra is removed after three weeks regenerating a new dermal tissue. So it can be applied a thin skin graft until healing of all patients.
authors.affiliation: Department of General and Geriatric Surgery, School of Medicine. Second University of Naples, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Campitiello
authors.forename: A
authors.initials: A
authors.lastname: Della Corte
authors.forename: A
authors.initials: A
authors.lastname: Fattopace
authors.forename: D
authors.initials: D
authors.lastname: D'Acunzi
authors.forename: S
authors.initials: S
authors.lastname: Canonico
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002809:Chondroitin Sulfates; D002908:Chronic Disease; D003094:Collagen; D062109:Dermatologic Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000293:injuries*; D017768:Skin, Artificial; D014945:Wound Healing
chemical_list: C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen