Is there a role for cytokine based therapies in fibromyalgia.
Cytokines are glycoproteins that serve as chemical messengers between cells. They assist in the regulation of cell growth and repair and also have immune modulating properties. Cytokines play a role in diverse clinical processes and phenomena such as fatigue, fever, sleep, pain, stress and aching. A review of the fibromyalgia literature and related studies suggest that IL-1, IL-6 and IL-8 are dysregulated in the syndrome. Therapies directed against these cytokines may be of potential importance in the management of fibromyalgia.
Wallace
Daniel J
DJ
Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dwallace@ucla.edu
D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D015673:Fatigue Syndrome, Chronic / Q000503:physiopathology; D005356:Fibromyalgia / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans
D016207:Cytokines