Detection of six copies of the capsulation b locus in a Haemophilus influenzae type b strain isolated from a splenectomized patient with fulminant septic shock.
We report on the first detection of six copies of the capsulation b locus in a Haemophilus influenzae type b strain isolated from a splenectomized patient with fulminant septic shock associated with disseminated intravascular coagulation and death. The unusual amplification of the locus might have contributed to the rare and severe clinical presentation.
Cerquetti
Marina
M
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. mcerquet@iss.it
Cardines
Rita
R
Giufrè
Maria
M
Castella
Annalisa
A
Rebora
Monica
M
Mastrantonio
Paola
P
Ciofi Degli Atti
Marta Luisa
ML
D000328:Adult; D016667:Bacterial Capsules / Q000235:genetics*; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D018628:Gene Dosage; D005798:Genes, Bacterial; D006192:Haemophilus Infections / Q000150:complications / Q000382:microbiology* / Q000601:surgery; D019741:Haemophilus influenzae type b / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D012772:Shock, Septic / Q000382:microbiology*; D013156:Splenectomy