[Inflammatory markers and adiponectin plasma level in patients with type 2 diabetes].
BACKGROUND
In patients with carbohydrate or lipid disturbances higher inflammatory markers levels and lower adiponectin levels were observed. These observations suggest the potential role of those markers in the pathogenesis of diabetes, obesity and atherosclerosis.


METHODS
25 type 2 diabetic patients (group A) and 15 patients without diabetes (group B) were included into the study. Glycated haemoglobin (HbAlc), total cholesterol and triglycerides, interleukin 6 (IL-6), tumor necrosis factor alpha (TNFalpha) and adiponectin levels were measured in blood samples. Fasting plasma glucose and fasting plasma insulin were measured to calculate index of insulin resistance (homeostasis model assessment--IR/HOMA-IR/).


RESULTS
Mean adiponectin level was significantly lower in patients with type 2 diabetes than in control patients (7,4 microg/ml vs 12,3 microg/ml; p<0,05). Blood levels of fasting insulin, IL-6, TNFalpha and HOMA-IR index were higher in people with diabetes than in control subjects but the differences were not statistically significant. No significant correlations were observed between adiponectin and inflammatory markers level and total cholesterol, triglyceride, HOMA-IR level and blood pressure.


CONCLUSIONS
The findings indicate that adiponectin level is lower in patients with type 2 diabetes. We did not manage to confirm significantly elevated inflammatory markers levels in this group of patients.
Zurawska-Kliś
Monika
M
Klinika Diabetologii z Oddziałem Farmakologii Klinicznej, Uniwersytet Medyczny w Lodzi. moniazur@wp.pl
Drzewoski
Józef
J
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D015850:Interleukin-6; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha