[The analysis of HLA-A, B and DRB1 allelic polymorphism in Han race population in Lanzhou region of China].
OBJECTIVE
To investigate the HLA-A, B and DRB1 allele polymorphism of the Han race population in Lanzhou area.


METHODS
Polymerase chain reaction-sequence specific primer was used to detect HLA-A, B and DRB1 alleles in 200 unrelated healthy Han individuals from Lanzhou region, Northwest China, and the results were compared with those of Han populations in North, South and Northwest China, and Hui, Uigur and Tibetan population in China.


RESULTS
Fourteen of alleles were detected and identified for HLA-A; 32 for HLA-B; and 13 for HLA-DRB1. HLA- A*01, A*02,A*11,A*24, A*30, A*31, A*33; HLA- B*13, B*15, B*40, B*44, B*46, B*51, B*58, B*60; HLA- DRB1*04,. DRB1*07, DRB1*08, DRB1*09, DRB1*11, DRB1*12, DRB1*14 and DRB1*15 were the most common alleles. The frequencies of HLA-A, B and DRB1 genes of Lanzhou Han race were close to that of North China Hans and Hui population in Northwest China, and a little different to that of South China Hans. The HLA-DRB1 alleles were significantly different to those of Uigur and Tibetan race population of China.


CONCLUSIONS
The allelic polymorphism of HLA-A,B and DRB1 loci of Han race population in Lanzhou area was between North and South Han race of China, close to Northwest China Hui, and markedly different to Northwest China Uigur and Tibetan race populations.
Li
Cai-li
CL
Laboratory Center for Medical Science, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Tang
Zhao-hui
ZH
Fang
Li-hua
LH
Li
Yuan-rong
YR
Su
Hai-xiang
HX
Wei
Hu-lai
HL
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains