Proliferative nodules with balloon-cell change in a large congenital melanocytic nevus.
The balloon-cell nevus was first described over 100 years ago. Since then, balloon-cell changes of melanocytes have been noted in numerous tumors, including melanoma, blue nevus, and Spitz nevus. Whether these changes reflect cellular deterioration or proliferative changes is a matter of debate. We report a case in which balloon-cell changes were found within proliferative nodules occurring in a large congenital melanocytic nevus.
McGowan
Joseph W
JW
Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Smith
Molly K
MK
Ryan
Michael
M
Hood
Antoinette F
AF
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000737:chemistry / Q000473:pathology*; D009508:Nevus, Pigmented / Q000737:chemistry / Q000151:congenital* / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000151:congenital* / Q000473:pathology*
D014408:Biomarkers, Tumor