[Diffuse large B-cell lymphoma with strongly positive MIB-1 stain and clinical features resembling Burkitt lymphoma].
A 62-year-old woman was admitted to our hospital because of gastric mucosal bleeding. Gastroendoscopy revealed a gastric tumor which was diagnosed from the biopsied specimen as diffuse large B-cell lymphoma (DLBCL). Lymphoma cells had infiltrated the bone marrow showed morphological features resembling Burkitt lymphoma (BL). Nearly 100% of the cells in the bone marrow were positive for MIB-1 immunostaining. The chromosomal study was normal. Surface marker analysis disclosed that the cells were positive for CD10, CD19, CD20 and CD25. As lymphoma cells had infiltrated the central nervous system, combined chemotherapy was performed accompanied with intrathecal administration of anticancer drugs. Although transient improvement was observed, the patient died of the advanced disease three months after admission. As we have shown here, there are some cases of DLBCL with immunohistochemical features resembling BL. Further consideration about the appropriate chemotherapy program for this type of disease might be necessary.
Wakimoto
Naoki
N
Department of Hematology, Saitama Medical School.
Misumi
Motohiro
M
Maeda
Tomoya
T
Shimada
Tsuneyuki
T
Wakao
Daisuke
D
Sato
Yasutaka
Y
Takahashi
Naoki
N
Sugahara
Yuichi
Y
Yoshida
Katsuhiko
K
Yagasaki
Fumiharu
F
Nakamura
Yuichi
Y
Kawai
Nobutaka
N
Matsuda
Akira
A
Kayano
Hidekazu
H
Jinnai
Itsuro
I
Bessho
Masami
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D002051:Burkitt Lymphoma; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse; D008875:Middle Aged
D015415:Biomarkers; D019394:Ki-67 Antigen