title: QTL and candidate genes for fecundity in sows.
abstract: Fecundity in pigs is a trait of major economic interest but low heritability. For the improvement of fecundity, genetic markers for selection are desirable and therefore, several searches for genetic variation influencing fecundity have been performed. The aim of this review is to compare and to evaluate all published QTL analyses and candidate gene approaches concerning reproductive traits in sows. For this purpose, we present a comprehensive cytogenetic map comprising 54 QTL and 11 candidate genes with influence on reproductive traits. The evaluation and comparison of the results showed similarities, but also marked differences among studies. Reasons for different results are multicausal and are due to differences between resource populations, number of evaluated animals, mating systems, measured phenotypical traits and environmental influences. We could show that chromosome 8 and to a lower extend chromosome 7 are the most important chromosomes with regard to reproductive traits in pigs. For further research, fine mapping of the identified QTL regions is necessary in order to confirm and to narrow the most likely chromosomal intervals. Although difficult to perform, an advance would be a standardization of the experimental setup in particular, in respect to the collection of phenotypic data. Furthermore, we suggest to publish the information on further identified QTL and candidate genes as comprehensive and accurate as possible in order to allow a more transparent comparison and collation of the results.
authors.affiliation: Humboldt-University of Berlin, Agricultural and Horticultural Faculty, Institute of Animal Sciences, Department of Breeding Biology and Molecular Genetics, 10115 Berlin, Invalidenstr. 42, Germany. bernd.buske@staff.hu-berlin.de
authors.forename: Bernd
authors.initials: B
authors.lastname: Buske
authors.forename: Ina
authors.initials: I
authors.lastname: Sternstein
authors.forename: Gudrun
authors.initials: G
authors.lastname: Brockmann
mesh_terms: D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping / Q000662:veterinary; D020732:Cytogenetic Analysis / Q000662:veterinary; D004777:Environment; D005260:Female; D005298:Fertility / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D008098:Litter Size; D008297:Male; D040641:Quantitative Trait Loci / Q000235:genetics*; D012098:Reproduction / Q000235:genetics; D012741:Sexual Maturation; D013552:Swine / Q000235:genetics*