title: Targeting cancer cells: magnetic nanoparticles as drug carriers.
abstract: Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.
authors.affiliation: Klinik und Poliklinik für Hals- Nasen- Ohren- kranke, Universität Erlangen - Nürnberg, Erlangen, Germany. C.Alexiou@web.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Alexiou
authors.forename: Roswitha J
authors.initials: RJ
authors.lastname: Schmid
authors.forename: Roland
authors.initials: R
authors.lastname: Jurgons
authors.forename: Marcus
authors.initials: M
authors.lastname: Kremer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Wanner
authors.forename: Christian
authors.initials: C
authors.lastname: Bergemann
authors.forename: Ernst
authors.initials: E
authors.lastname: Huenges
authors.forename: Thomas
authors.initials: T
authors.lastname: Nawroth
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Arnold
authors.forename: Fritz G
authors.initials: FG
authors.lastname: Parak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology*; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D008280:Magnetics / Q000627:therapeutic use*; D008942:Mitoxantrone / Q000008:administration & dosage* / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D008942:Mitoxantrone