title: Characterization and in vitro bioactivity of zinc-containing bioactive glass and glass-ceramics.
abstract: Zinc-containing glass is prepared by the substitution of CaO in 58S bioactive glass with 0.5 and 4 wt% ZnO, and glass-ceramics are obtained by heat-treating the glass at 1,200 C. The bending strength and in vitro bioactivity of the glass and glass-ceramics are evaluated. The results indicate that Zn promotes the crystallization of SiO(2) and wollastonite in glass-ceramics, and proper crystallization can enhance the bending strength of the glass-ceramic. The in vitro results show that ZnO in glass retards the hydroxyapatite (HA) nucleation at the initial stage of simulated body fluid (SBF) soaking, but does not affect the growth of HA after long periods of soaking, and the ionic products of 58S4Z glass can stimulate the proliferation of osteoblast at certain concentrations. Osteoblasts attach well on both glass samples and glass-ceramic samples, but the high Si ion concentration released from glass samples restrains the proliferation of osteoblasts after 3 days of culture. In contrast, osteoblasts show good proliferation on glass-ceramic samples, and ZnO in glass-ceramics promotes the proliferation rate. The results in this study suggest that the glass and glass-ceramics with different ZnO content might be used as bioactive bone implant materials in different applications.
authors.affiliation: Graduate School of the Chinese Academy of Sciences, Shanghai, China 200050.
authors.forename: Rui Lin
authors.initials: RL
authors.lastname: Du
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.forename: Si Yu
authors.initials: SY
authors.lastname: Ni
authors.forename: Wan Yin
authors.initials: WY
authors.lastname: Zhai
authors.forename: Jun Ying
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001826:Body Fluids / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties; D015032:Zinc / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; C448994:bioactive glass 58S; D015032:Zinc