title: Role of Caco-2 cell monolayers in prediction of intestinal drug absorption.
abstract: The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.
authors.affiliation: Department of Pharmacy, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Post Box 51, Kalabhavan, Vadodara 390 001, India.
authors.forename: Pranav
authors.initials: P
authors.lastname: Shah
authors.forename: Viral
authors.initials: V
authors.lastname: Jogani
authors.forename: Tamishraha
authors.initials: T
authors.lastname: Bagchi
authors.forename: Ambikanandan
authors.initials: A
authors.lastname: Misra
mesh_terms: D018938:Caco-2 Cells; D020895:Enterocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011237:Predictive Value of Tests
chemical_list: D004364:Pharmaceutical Preparations