An angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour.
A compound that inhibited angiotensin-I converting enzyme (ACE) activity was isolated from buckwheat powder. This compound is thought to be the hydroxy derivative of nicotianamine and its chemical structure is 2''-hydroxynicotianamine. This compound showed a very high inhibitory activity toward ACE, and the IC(50) was 0.08 microM. Only this hydroxy analog was found in buckwheat powder, at about 30 mg/100g, and no nicotianamine was detected. However, nicotianamine was detected in the buckwheat plant body. 2''-hydroxynicotianamine was also found in other polygonaceous plants.
Aoyagi
Yasuo
Y
Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan. aoyagi@eiyo.ac.jp
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001383:Azetidinecarboxylic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D019612:Fagopyrum / Q000737:chemistry*; D005433:Flour; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; C082893:nicotianamine; D001383:Azetidinecarboxylic Acid; D007703:Peptidyl-Dipeptidase A