Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni.
We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.
Keiser
Jennifer
J
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. jennifer.keiser@unibas.ch
Brun
Reto
R
Fried
Bernard
B
Utzinger
Jürg
J
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology* / Q000627:therapeutic use; D004449:Echinostoma / Q000187:drug effects*; D004451:Echinostomiasis / Q000188:drug therapy*; D005260:Female; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000494:pharmacology* / Q000627:therapeutic use
D000871:Anthelmintics; D037621:Artemisinins; D012717:Sesquiterpenes; D011223:Praziquantel; C031327:artemisinin