Synthesis and preliminary in vitro evaluation of 5'-O-esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with alpha-lipoic acid as potential prodrugs.
Kryczka
Tomasz
T
Department of Experimental Pharmacology, Polish Academy of Sciences Medical Research Center, Warsaw, Poland.
Stachnik
Krzysztof
K
Kozłowska
Mariola
M
Kazimierczuk
Zygmunt
Z
Hovinen
Jari
J
Chrapusta
Stanisław J
SJ
Grieb
Paweł
P
D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D017338:Cladribine / Q000138:chemical synthesis / Q000494:pharmacology*; D003839:Deoxyadenosines / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D011355:Prodrugs / Q000138:chemical synthesis / Q000494:pharmacology*; D008063:Thioctic Acid / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000975:Antioxidants; D003839:Deoxyadenosines; D011355:Prodrugs; D017338:Cladribine; D008063:Thioctic Acid; C058118:2'-deoxyadenosine