title: Monoamine receptors in human corneal epithelium and endothelium.
abstract: OBJECTIVE
  Monoamine receptors are found throughout the body. Reports about the presence of monoamine receptors in the human cornea are inconsistent.
  
  
  METHODS
  Immunohistochemistry, immunofluorescence and immunoblotting were used to localize monoamine receptor sites on human corneal epithelium and endothelium.
  
  
  RESULTS
  Antibodies to alpha-1, beta-1 and beta-2 adrenergic receptors and to D1-like and 5HT-7 receptors were bound in corneal epithelium. Antibodies to alpha-1, alpha-2A, beta-1 and beta-2 adrenergic receptors and to 5HT-7 receptors were bound in corneal endothelium.
  
  
  CONCLUSIONS
  Our data demonstrate the presence of several monoamine receptors in the human cornea. These receptors may play a role in the regulation of fluid transport or corneal homeostasis.
authors.affiliation: Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany. matthias.grueb@med.uni-tuebingen.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Grueb
authors.forename: Barbara
authors.initials: B
authors.lastname: Wallenfels-Thilo
authors.forename: Oliver
authors.initials: O
authors.lastname: Denk
authors.forename: Joerg
authors.initials: J
authors.lastname: Mielke
authors.forename: Eva
authors.initials: E
authors.lastname: Reinthal
authors.forename: Jens Martin
authors.initials: JM
authors.lastname: Rohrbach
authors.forename: Karl Ulrich
authors.initials: KU
authors.lastname: Bartz-Schmidt
mesh_terms: D000328:Adult; D000368:Aged; D015153:Blotting, Western; D004728:Endothelium, Corneal / Q000378:metabolism*; D019573:Epithelium, Corneal / Q000378:metabolism*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor