title: Correlation between in vitro release from topical delivery vehicles and microbicidal activity of triclosan.
abstract: This study reports the formulation, stability, in vitro release and microbicidal activity of a cream, emulsion, foot gel, cover stick and after sun spray containing triclosan. Triclosan is a broad-spectrum antimicrobial agent with activity against a wide range of both gram-negative and gram-positive bacteria that has found increasing popular use in personal care products. These products were stable for up to 3 months when stored at 5, 25, and 40 degrees C. Antimicrobial zone inhibition tests showed that that was a liner relationship, R2 > 0.92, between the release of triclosan from these products and the size of the inhibition zones. This means the in vitro/in vivo correlation for these products was good and that release studies can be used to predict the antimicrobial activity of triclosan.
authors.affiliation: Research Institute for Industrial Pharmacy, School of Pharmacy, North-West University, Potchefstroom, South Africa.
authors.forename: H C
authors.initials: HC
authors.lastname: Swart
authors.forename: J L
authors.initials: JL
authors.lastname: Du Preez
authors.forename: M M
authors.initials: MM
authors.lastname: De Villiers
authors.forename: A P
authors.initials: AP
authors.lastname: Lötter
authors.forename: W
authors.initials: W
authors.lastname: Liebenberg
mesh_terms: D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D008826:Microbial Sensitivity Tests; D014677:Pharmaceutical Vehicles; D013056:Spectrophotometry, Ultraviolet; D014260:Triclosan / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000891:Anti-Infective Agents, Local; D014677:Pharmaceutical Vehicles; D014260:Triclosan