Preparation of massive anti-infective reconstituted bone xenograft and related studies.
The purpose of this study was to develop a new type of anti-infective bone transplantation material. A massive anti-infective reconstituted bone xenograft with calcium phosphate drug core (CPC-MARBX) was prepared; a drug delivery profile and capability of repairing large segmental infected bony defect were characterized with drug delivery tests and in the rabbit model with large segmental infected bony defect. CPC-MARBX was produced with relatively simple procedures. The duration of the drug delivery was about 25 days in vitro and 30 days in vivo. The infected bony defect was successfully repaired with good healing. CPC-MARBX is readily available and can be applied in repairing the large segmental infected bony defect.
Sun
Xiaotang
X
Department of Orthopedic Surgery, Xijing Hospital, Xi'an, China.
Zhao
Li
L
Hu
Yunyu
Y
Yuan
Zhi
Z
Ji
Qiang
Q
Li
Mingquan
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000295:instrumentation*; D002130:Calcium Phosphates / Q000737:chemistry; D002417:Cattle; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005269:Femur / Q000293:injuries / Q000601:surgery; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology; D011183:Postoperative Complications; D011817:Rabbits; D013203:Staphylococcal Infections / Q000209:etiology / Q000517:prevention & control; D014183:Transplantation, Heterologous
D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; D002130:Calcium Phosphates; D004337:Drug Carriers; D005839:Gentamicins; C020243:calcium phosphate