title: [Features of regeneration of joint cartilage during osteoarthritis].
abstract: In order to define the features of regeneration of joint cartilage during osteoarthritis, morphological study of surgical material, obtained from 50 patients, has been performed with the help of histological, histochemical and morphometric methods. In the joint cartilage, alongside with the alteration, there is also the cellular regeneration expressing in the intensive proliferation of cartilaginous cells. However, maturing of the regenerated cells proceeds defectively and consequently regenerate loses ability to be differentiated in hyaline, joint cartilage that specifies the phase of differentiation. Hence, the specified process should be qualified as not reparation, but as a pathological regeneration. Cartilaginous regenerate is not capable to carry out amortization and protective functions of an articulate cartilage and is exposed to secondary alteration. The last, in turn, aggravates arthroses changes and causes progressing disease.
authors.forename: R T
authors.initials: RT
authors.lastname: Chikhladze
authors.forename: M I
authors.initials: MI
authors.lastname: Chkhaidze
mesh_terms: D002356:Cartilage / Q000166:cytology* / Q000502:physiology*; D005269:Femur / Q000473:pathology*; D006622:Hip Prosthesis; D006801:Humans; D007596:Joints / Q000166:cytology* / Q000502:physiology*; D010003:Osteoarthritis / Q000473:pathology* / Q000601:surgery*; D012038:Regeneration / Q000502:physiology*