title: Test-retest reproducibility of a food frequency questionnaire (FFQ) and estimated effects on disease risk in the Norwegian Women and Cancer Study (NOWAC).
abstract: BACKGROUND
  The Norwegian Women and Cancer Study (NOWAC) is a national population-based cohort study with 102 443 women enrolled at age 30-70 y from 1991 to 1997. The present study was a methodological sub-study to assess the test-retest reproducibility of the NOWAC food frequency questionnaire (FFQ), and to study how measurement errors in the data can affect estimates of disease risk.
  
  
  METHODS
  A random sample of 2000 women aged 46-75 y was drawn from the cohort in 2002. A self-instructive health and lifestyle questionnaire with a FFQ section was mailed to the same subjects twice (test-retest), about three months apart, with a response rate of 75%. The FFQ was designed to assess habitual diet over the past year. We assess the reproducibility of single questions, food groups, energy, and nutrients with several statistical measures. We also demonstrate the method of regression calibration to correct disease risk estimates for measurement error. Alcohol intake (g/day) and high blood pressure (yes/no) is used in the example.
  
  
  RESULTS
  For single foods there were some indications of seasonal reporting bias. For food groups and nutrients the reliability coefficients ranged from 0.5-0.8, and Pearson's r, Spearman's rs, and two intraclass correlation coefficients gave similar results. Although alcohol intake had relatively high reproducibility (r = 0.72), odds ratio estimates for the association with blood pressure were attenuated towards the null value compared to estimates corrected by regression calibration.
  
  
  CONCLUSIONS
  The level of reproducibility observed for the FFQ used in the NOWAC study is within the range reported for similar instruments, but may attenuate estimates of disease risk.
authors.affiliation: Institute of Basic Medical Sciences, Department of Biostatistics, University of Oslo, PO Box 1122 Blindern, N-0317 Oslo, Norway. christine.parr@basalmed.uio.no
authors.forename: Christine L
authors.initials: CL
authors.lastname: Parr
authors.forename: Marit B
authors.initials: MB
authors.lastname: Veierød
authors.forename: Petter
authors.initials: P
authors.lastname: Laake
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Anette
authors.initials: A
authors.lastname: Hjartåker
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D015982:Bias; D001794:Blood Pressure; D015331:Cohort Studies; D004032:Diet; D015930:Diet Records; D002149:Energy Intake; D005260:Female; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D009664:Norway / Q000453:epidemiology; D009747:Nutritional Physiological Phenomena; D016017:Odds Ratio; D015203:Reproducibility of Results; D012307:Risk Factors; D012621:Seasons; D011795:Surveys and Questionnaires; D016387:Women's Health