Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children.
There is a relationship between the fatty acid profile in skeletal muscle phospholipids and peripheral resistance to insulin in adults, but similar data have not been reported in infancy and childhood. The objective of this study was to investigate the fatty acid composition of skeletal muscle and adipose tissue across the paediatric age range. The fatty acid profile of skeletal muscle phospholipids and adipose tissue triacylglycerols was analysed in ninety-three healthy Spanish infants and children distributed into four groups: group 1 (0 to <2 years, n 10); group 2 (2 to <5 years, n 41); group 3 (5 to <10 years, n 24); group 4 (10 to 15 years, n 18). In skeletal muscle phospholipids, oleic acid (18: 1n-9cis) content decreased significantly whereas that of linoleic (18: 2n-6) acid increased significantly with age (P for trend <0.01). In adipose tissue, the contents of triacylglycerol and linoleic acid increased significantly across the paediatric age range (P for trend <0.01), whereas dihomo-gamma-linolenic (20: 3n-6) and arachidonic (20: 4n-6) showed significant differences between groups. The variations in fatty acid composition observed with age indicated an imbalance in dietary n-3/n-6 long-chain PUFA.
Sanjurjo
Pablo
P
Division of Metabolism, Hospital de Cruces and Basque University School of Medicine, Bilbao, Spain. psanjurjo@hcru.osakidetza.net
Aldámiz-Echevarría
Luis
L
Prado
Carmen
C
Azcona
Isabel
I
Elorz
Javier
J
Prieto
José A
JA
Ruiz
José I
JI
Rodríguez-Soriano
Juan
J
D015126:8,11,14-Eicosatrienoic Acid / Q000032:analysis; D000273:Adipose Tissue / Q000737:chemistry*; D000293:Adolescent; D016718:Arachidonic Acid / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry*; D019301:Oleic Acid / Q000032:analysis; D019308:Palmitic Acid / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D014280:Triglycerides / Q000032:analysis; D017962:alpha-Linolenic Acid / Q000032:analysis
D005227:Fatty Acids; D010743:Phospholipids; D014280:Triglycerides; D017962:alpha-Linolenic Acid; D016718:Arachidonic Acid; D019301:Oleic Acid; D019308:Palmitic Acid; D015126:8,11,14-Eicosatrienoic Acid