Proteomics of the human malaria parasite Plasmodium falciparum.
The lethal species of malaria parasite, Plasmodium falciparum, continues to exact a huge toll of mortality and morbidity, particularly in sub-Saharan Africa. Completion of the genome sequence of this organism and advances in proteomics and mass spectrometry have opened up unprecedented opportunities for understanding the complex biology of this parasite and how it responds to drug challenge and other interventions. This review describes recent progress that has been made in applying proteomics technology to this important pathogen and provides a look forward to likely future developments.
Sims
Paul F G
PF
University of Manchester, Faculty of Life Sciences, Jackson's Mill, PO Box 88, Manchester, M60 1QD, UK. paul.sims@manchester.ac.uk
Hyde
John E
JE
D000818:Animals; D006801:Humans; D008288:Malaria / Q000469:parasitology*; D010271:Parasites / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics
D020543:Proteome