title: Chemokines in rheumatic diseases.
abstract: Chemotactic cytokines, termed chemokines, mediate the ingress of leukocytes into the inflamed synovium. In this review, authors discuss the role of the most relevant chemokines and chemokine receptors involved in chronic inflammatory rheumatic diseases. Rheumatoid arthritis was chosen as a prototype to discuss these issues, as the majority of studies on the role of chemokines in inflammatory diseases were carried out in arthritis. However, other rheumatic diseases including systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, mixed connective tissue disease, polymyositis/dermatomyositis, antiphospholipid syndrome and systemic vasculitides are also discussed in this context. Apart from discussing the pathogenic role of chemokines and their receptors, authors also review the regulation of chemokine production by other inflammatory mediators, as well as the important relevance of chemokines for antirheumatic therapies.
authors.affiliation: Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H-4004, Hungary. szekanecz@iiibel.dote.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szekanecz
authors.forename: Gabriella
authors.initials: G
authors.lastname: Szücs
authors.forename: Sándor
authors.initials: S
authors.lastname: Szántó
authors.forename: Alisa E
authors.initials: AE
authors.lastname: Koch
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology*; D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000503:physiopathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000503:physiopathology; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D012216:Rheumatic Diseases / Q000503:physiopathology*; D025242:Spondylarthropathies / Q000188:drug therapy / Q000503:physiopathology; D013585:Synovitis / Q000378:metabolism
chemical_list: D018501:Antirheumatic Agents; D018925:Chemokines