On the role of intramural nerves in the pathogenesis of cholera toxin-induced intestinal secretion.
Intestinal secretion was produced in anesthetized cats and rats by exposing isolated intestinal segments to cholera enterotoxin. Giving, for example, tetrodotoxin, a nerve-conduction-blocking agent, or adding lidocaine, a local anesthetic agent, to the solution in the intestinal segments markedly inhibited the rate of choleraic secretion, and in most experiments a net absorption of fluid was observed. The results suggest that intramural nervous mechanisms are involved in the pathogenesis of choleraic secretion.
Cassuto
J
J
Dept. of Physiology, University of Gothenburg, Gothenburg, Sweden.
Jodal
M
M
Tuttle
R
R
Lundgren
O
O
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D002415:Cats; D002447:Celiac Plexus / Q000187:drug effects*; D002771:Cholera / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D002772:Cholera Toxin / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D007419:Intestinal Secretions / Q000378:metabolism*; D007583:Jejunum / Q000294:innervation* / Q000378:metabolism; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D011042:Poisons / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013779:Tetrodotoxin / Q000494:pharmacology
D000779:Anesthetics, Local; D011042:Poisons; D013779:Tetrodotoxin; D002772:Cholera Toxin; D008012:Lidocaine