Detection of susceptibility loci by genome-wide linkage analysis.
The objective of this study is to evaluate the efficacy of a model-free linkage statistics for finding evidence of linkage using two different maps and to illustrate how the comparison of results from several populations might provide insight into the underlying genetic etiology of the disease of interest. The results obtained in terms of detection of the risk loci and threshold for declaring linkage and power are very similar for a dense SNP map and a sparser microsatellite map. The populations differed in terms of family ascertainment and diagnosis criteria, leading to different power to detect the individual underlying disease loci. Our results for the individual replicates are consistent with the disease model used in the simulation.
Babron
Marie-Claude
MC
INSERM U535, 94817 Villejuif Cedex, Villejuif, France. babron@vjf.inserm.fr
Bourgain
Catherine
C
Leutenegger
Anne-Louise
AL
Clerget-Darpoux
Françoise
F
D002874:Chromosome Mapping / Q000379:methods*; D008040:Genetic Linkage; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results