title: A pregnant woman with anti-Gregory antigen: case report.
abstract: Negative Gregory antigen (Gy(a-)) remains an extremely uncommon blood phenotype. We describe a 32-year-old pregnant woman with (Gy(a-)) and anti-Gregory antigen (anti-Gy(a)). There was no evidence of consanguineous mating in her family. Blood typing study revealed that only her father was Gy(a-) among the family. Anti-Gy(a) had a titer of 16 before pregnancy, but increased to 1024 at 33 weeks of gestation with a titer of 512 at 34 weeks. Her own blood stores were collected starting at 14 weeks, amounting to 1800 g totally. She underwent an emergency cesarean section at 35 weeks due to a non-reassuring fetal status. Blood loss was approximately 1090 g. Cord blood type was found to be Gy(a-). The indirect Coombs test of cord blood was positive, while the direct Coombs test was negative. No neonatal hemorrhagic disease developed. The storage of a sufficient amount of crossmatch-compatible Gy(a-) blood during pregnancy is important in case of possible need of blood transfusion at delivery for women with anti-Gy(a).
authors.affiliation: Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takamatsu
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: N
authors.initials: N
authors.lastname: Ohara
authors.forename: N
authors.initials: N
authors.lastname: Makihara
authors.forename: T
authors.initials: T
authors.lastname: Funakoshi
authors.forename: T
authors.initials: T
authors.lastname: Moriyama
authors.forename: T
authors.initials: T
authors.lastname: Maruo
mesh_terms: D000328:Adult; D001789:Blood Group Antigens / Q000276:immunology*; D001788:Blood Grouping and Crossmatching; D003298:Coombs Test; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D011247:Pregnancy / Q000097:blood*; D011256:Pregnancy Outcome
chemical_list: D001789:Blood Group Antigens; D007518:Isoantibodies