title: Role of apolipoproteins in gammadelta and NKT cell-mediated innate immunity.
abstract: Recent findings reveal unanticipated connections between the fields of lipid metabolism and immunology. They concern gammadelta and NKT cells, nonconventional T cell populations that do not recognize protein antigens and are involved in immunity against cancer, defense against infections, or in regulation of classical immune responses. In this review, we summarize data linking perturbations of apolipoprotein levels and nonconventional T cells with inflammatory processes such as autoimmune diseases or atherosclerosis. We integrate and discuss recent findings on the implication of apolipoproteins in antigen recognition by gammadelta and NKT cells, with emphasis on apolipoproteins A-I and E. These findings also provide indications that apolipoproteins influence antitumor immunosurveillance.
authors.affiliation: Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Departement Lipoproteines et Médiateurs Lipidiques, Toulouse, France. Eric.Champagne@toulouse.inserm.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Champagne
authors.forename: Laurent O
authors.initials: LO
authors.lastname: Martinez
authors.forename: Pierre
authors.initials: P
authors.lastname: Vantourout
authors.forename: Xavier
authors.initials: X
authors.lastname: Collet
authors.forename: Ronald
authors.initials: R
authors.lastname: Barbaras
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D001053:Apolipoproteins; D016692:Receptors, Antigen, T-Cell, gamma-delta