title: Progressive coronary calcification despite intensive lipid-lowering treatment: a randomised controlled trial.
abstract: OBJECTIVE
  To evaluate the effect of intensive lipid-lowering treatment on coronary artery calcification in a substudy of a trial recruiting patients with calcific aortic stenosis.
  
  
  METHODS
  In a double blind randomised controlled trial, 102 patients with calcific aortic stenosis and coronary artery calcification were randomly assigned by the minimisation technique to atorvastatin 80 mg daily or matched placebo. Coronary artery calcification was assessed annually by helical computed tomography.
  
  
  RESULTS
  48 patients were randomly assigned to atorvastatin and 54 to placebo with a median follow up of 24 months (interquartile range 24-30). Baseline characteristics and coronary artery calcium scores were similar in both groups. Atorvastatin reduced serum low density lipoprotein cholesterol (-53%, p < 0.001) and C reactive protein (-49%, p < 0.001) concentrations whereas there was no change with placebo (-7% and 17%, p > 0.95 for both). The rate of change in coronary artery calcification was 26%/year (0.234 (SE 0.037) log arbitrary units (AU)/year; n = 39) in the atorvastatin group and 18%/year (0.167 (SE 0.034) log AU/year; n = 49) in the placebo group, with a geometric mean difference of 7%/year (95% confidence interval -3% to 18%, p = 0.18). Serum low density lipoprotein concentrations were not correlated with the rate of progression of coronary calcification (r = 0.05, p = 0.62).
  
  
  CONCLUSIONS
  In contrast to previous observational studies, this randomised controlled trial has shown that, despite reducing systemic inflammation and halving serum low density lipoprotein cholesterol concentrations, statin treatment does not have a major effect on the rate of progression of coronary artery calcification.
authors.affiliation: Department of Cardiology, Royal Infirmary, Edinburgh, UK.
authors.forename: E S
authors.initials: ES
authors.lastname: Houslay
authors.forename: S J
authors.initials: SJ
authors.lastname: Cowell
authors.forename: R J
authors.initials: RJ
authors.lastname: Prescott
authors.forename: J
authors.initials: J
authors.lastname: Reid
authors.forename: J
authors.initials: J
authors.lastname: Burton
authors.forename: D B
authors.initials: DB
authors.lastname: Northridge
authors.forename: N A
authors.initials: NA
authors.lastname: Boon
authors.forename: D E
authors.initials: DE
authors.lastname: Newby
mesh_terms: D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000188:drug therapy*; D000069059:Atorvastatin; D002114:Calcinosis / Q000188:drug therapy*; D003324:Coronary Artery Disease / Q000188:drug therapy*; D018450:Disease Progression; D004311:Double-Blind Method; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000627:therapeutic use*; D036542:Tomography, Spiral Computed; D017211:Treatment Failure
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin