title: The new clearance method for hepatic diagnostics.
abstract: New multiparametric analysis and method of their evaluation were derived. The bolus dye injection is used for evaluation of ICG (indicyaningreen) and BSP (bromsulphophtalein) kinetics. This arrangement is a form of spectrophotometric measurement of BSP in plasma and/or pulse dye densitometry of ICG. Clearance values enable to differentiate liver diseases and to add their clinical staging. Pathophysiology of dye kinetics is discussed from two points of view i.e. sinusoidal and canalicular membrane transfer.
authors.affiliation: Institute of Civilization Diseases, Prague, Czech Republic.
authors.forename: J A
authors.initials: JA
authors.lastname: Tichý
authors.forename: M
authors.initials: M
authors.lastname: Loucka
authors.forename: Z M
authors.initials: ZM
authors.lastname: Trefný
mesh_terms: D004396:Coloring Agents; D006801:Humans; D007202:Indicators and Reagents; D007208:Indocyanine Green; D008107:Liver Diseases / Q000175:diagnosis*; D008111:Liver Function Tests / Q000379:methods*; D013448:Sulfobromophthalein
chemical_list: D004396:Coloring Agents; D007202:Indicators and Reagents; D013448:Sulfobromophthalein; D007208:Indocyanine Green