title: 5. IgE, mast cells, basophils, and eosinophils.
abstract: IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment, becomes fixed to FcepsilonRI on the membranes of mast cells and basophils. Aggregation of receptor-bound IgE molecules on re-exposure to specific allergen results in the production of mediators that produce the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil.
authors.affiliation: Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Building 10, Rm. 11C-205, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Calman
authors.initials: C
authors.lastname: Prussin
authors.forename: Dean D
authors.initials: DD
authors.lastname: Metcalfe
mesh_terms: D000818:Animals; D001491:Basophils / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D004804:Eosinophils / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis / Q000502:physiology*; D007249:Inflammation / Q000276:immunology; D008407:Mast Cells / Q000378:metabolism / Q000502:physiology*; D017455:Receptors, IgE / Q000378:metabolism
chemical_list: D017455:Receptors, IgE; D007073:Immunoglobulin E