Total synthesis of floresolide B and Delta(6,7)-Z-floresolide B.
The total syntheses of the cytotoxin marine natural product floresolide B (1) and its Delta(6,7)-Z isomer (2) have been achieved through an olefin metathesis-based strategy.
Nicolaou
K C
KC
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. kcn@scripps.edu
Xu
Hao
H
D000475:Alkenes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis; D007536:Isomerism; D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D008387:Marine Toxins / Q000138:chemical synthesis*; D008956:Models, Chemical
D000475:Alkenes; D000970:Antineoplastic Agents; D001688:Biological Products; D047028:Macrocyclic Compounds; D008387:Marine Toxins; C519225:floresolide B