title: Harnessing the immune system against human glioma.
abstract: Our studies are directed toward immune resistance to glial tumors, particularly in children. Initial experiments indicate that it is possible to boost both innate natural killer T lymphocytes and adaptive CD4+ and CD8+ T cells by targeting the appropriate antigens to dendritic cells. Our hypothesis is that optimal vaccination approaches against cancer will need to recruit both innate and adaptive defense mechanisms.
authors.affiliation: The Rockefeller University, Laboratory of Cellular Physiology & Immunology, 1230 York Ave., New York, NY 10021, USA. dhodapk@mail.rockefeller.edu
authors.forename: Kavita M
authors.initials: KM
authors.lastname: Dhodapkar
authors.forename: Devi
authors.initials: D
authors.lastname: Banerjee
authors.forename: Ralph M
authors.initials: RM
authors.lastname: Steinman
mesh_terms: D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D019496:Cancer Vaccines / Q000627:therapeutic use*; D005910:Glioma / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate
chemical_list: D019496:Cancer Vaccines