title: Celebrex offers a small protection from root resorption associated with orthodontic movement.
abstract: Tooth movement results from alveolar bone resorption/deposition following application of orthodontic forces, and root resorption can be an undesirable complication associated with this process. No treatment for external root resorption is available to date.
  
  
  OBJECTIVE
  To determine if COX-2 inhibitors like Celebrex are effective in protecting root resorption associated with orthodontic forces.
  
  
  METHODS
  A force of 80 grams was applied to the left maxillary first molars of 7-week-old female Wistar rats using nickel titanium closed coil springs attached to the cervical area of the incisors with 0.010 stainless-steel ligature wires. Twenty animals were divided into three experimental groups: one receiving no treatment, the second receiving 25mg/kg, and the third receiving 50 mg/kg of celecoxib (Celebrex) in their drinking water. Rats were maintained on a soft diet and euthanized two weeks after initial placement of the force. Paraffin-embedded sections of the right (control) and left (experimental) maxillae were stained with H&E and the areas of root resorption were examined by counting the number of lacunaes in the roots.
  
  
  RESULTS
  No difference in the distance of tooth movement (0.5 mm/two weeks) was seen in all three groups. The rats that received the low dose of Celebrex showed no statistically significant difference in root resorption than that of the rats that received no dose. The rats that received the high dose of Celebrex showed a lower number of lacunaes (mean = 3.5) than that of the control group (mean 10.2; p=0.02).
  
  
  CONCLUSIONS
  Administration of Celebrex during the application of orthodontic forces does not interfere with tooth movement and appears to offer some slight protection against root resorption.
authors.affiliation: University of Southern California School of Dentistry, Los Angeles 90033, USA.
authors.forename: John
authors.initials: J
authors.lastname: Jerome
authors.forename: Timothy
authors.initials: T
authors.lastname: Brunson
authors.forename: Gerald
authors.initials: G
authors.lastname: Takeoka
authors.forename: Chad
authors.initials: C
authors.lastname: Foster
authors.forename: Hong B
authors.initials: HB
authors.lastname: Moon
authors.forename: Enrique
authors.initials: E
authors.lastname: Grageda
authors.forename: Maggie
authors.initials: M
authors.lastname: Zeichner-David
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D003722:Dental Alloys; D005260:Female; D008963:Molar; D009532:Nickel; D009969:Orthodontic Wires; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000473:pathology / Q000517:prevention & control*; D013314:Stress, Mechanical; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use*; D014025:Titanium; D019227:Tooth Apex / Q000473:pathology; D019237:Tooth Cervix / Q000473:pathology; D014087:Tooth Movement Techniques / Q000009:adverse effects* / Q000295:instrumentation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D003722:Dental Alloys; D011720:Pyrazoles; D013449:Sulfonamides; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium; D000068579:Celecoxib