title: [Temporal evolution of platelets and anti-platelet antibodies in patients of endemic area with non complicated malaria].
abstract: OBJECTIVE
  To evaluate the number of platelets and the title of anti-platelet antibodies IgG Ac-PI (by flow cytometry) in patients with non-complicated malaria.
  
  
  METHODS
  Descriptive, prospective and longitudinal study from 45 patients (aged among 14-67). Thirty patients were followed during 7 days.
  
  
  RESULTS
  A) Pretreatment: it was found malarial thrombocytopenia (MT) in 71 % and significant association between MT and Ac-PI in 33 %. MT was not associated to residence zone, to have had malaria in the last year and Plasmodium species but sex associated (males, p= 0.02078195), although, the Ac-PI titers of male and female was similar. Correspondingly, the number of platelets was statistically similar to the values of above variables. There was a low and an inverse lineal correlation between platelets and titres of Ac-P1 (r= -0.342 (p= 0.02310)). B) During the following, multiple linear regression among platelets, age, years of residence in the zone, number of malaria episodes in the last year, parasitaemia (logarithmically expressed) and Ac-P1 titers showed no significant coefficient and the maximum explanation achieved (17%) was parasitaemia and Ac-P1 titers. Similar analysis among Ac-P1 and age, years of residence in the zone number of malaria episodes in the last year, parasitaemia (logarithmically expressed) showed that the first three explain 38 % of the changes in Ac-P1, whereas malaria episodes and years of residence in the zone explain 28%.
authors.affiliation: Grupo Malaria, Universidad de Antioquia, Medillín, Colombia.
authors.forename: A
authors.initials: A
authors.lastname: Ríos-Orrego
authors.forename: T
authors.initials: T
authors.lastname: Alvarez-Castillo
authors.forename: J
authors.initials: J
authors.lastname: Carmona-Fonseca
authors.forename: S
authors.initials: S
authors.lastname: Blair-Trujillo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008137:Longitudinal Studies; D008288:Malaria / Q000150:complications* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000150:complications / Q000276:immunology; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G