title: Paediatric kidney transplantation in small children-- a single centre experience.
abstract: Kidney transplantation (KTx) remains a challenging procedure in small children. This study presents our centre results. From 1983 to 2004, 40 of 442 paediatric KTx were performed in children with a body weight <11 kg. Median body weight was 9.2 kg (range: 7.2-10.9), median age was 2.7 years (range: 0.9-5.9). Preoperative dialysis was performed in 87.5%. In 24 cases (60%) grafts came from cadaveric (CAD) and in 16 cases (40%) from living related donors (LRD). Median donor age of CAD was 8 years (range: 1-40). The overall 1-, 5-, 10-, 15-year patient survival was 93%, 90%, 90% and 87% respectively. The overall 1-, 5-, 10-, 15-year graft survival was 90%, 80%, 66% and 56% respectively. There was no significant difference in survival of CAD or LRD grafts. Median follow-up was 13.7 years. Initial graft function rate was 100% for LRD and 79% for CAD. The relative glomerular filtration rate (GFR) showed no statistical difference between CAD and LRD. Main reasons for graft loss were chronic transplant nephropathy. Paediatric KTx is the treatment of choice even in very small children. Living donor KTx is the preferable donor source in terms of primary graft function and timing to transplantation.
authors.affiliation: Department of General, Visceral and Transplant Surgery, Hannover Medical School, Germany. becker.thomas@mh-hannover.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Becker
authors.forename: Michael
authors.initials: M
authors.lastname: Neipp
authors.forename: Benedikt
authors.initials: B
authors.lastname: Reichart
authors.forename: Lars
authors.initials: L
authors.lastname: Pape
authors.forename: Jochen
authors.initials: J
authors.lastname: Ehrich
authors.forename: Jürgen
authors.initials: J
authors.lastname: Klempnauer
authors.forename: Gisela
authors.initials: G
authors.lastname: Offner
mesh_terms: D000367:Age Factors; D001835:Body Weight; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007223:Infant; D007674:Kidney Diseases / Q000209:etiology / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D015233:Models, Statistical; D011183:Postoperative Complications; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents