title: Intestinal diffuse large B-cell lymphoma associated with celiac disease: a Japanese case.
abstract: Intestinal non-Hodgkin's lymphoma (NHL), especially the T-cell type, is well known to be associated with celiac disease (CD), an enteropathic disorder with a propensity for certain racial and genetic backgrounds. CD is typically characterized by gastrointestinal (GI) symptoms, anti-transglutaminase antibodies in the sera, and microscopical findings of the intestinal mucosa, which resolve with a gluten-free diet (GFD). In Asian populations, including the Japanese, CD and the associated NHL have been supposed to be quite rare, and studies concerning the frequency of CD or its relationship with NHL are scarce. We describe a Japanese middle-aged man with intestinal diffuse large B-cell lymphoma associated with CD. Following multi-combined chemotherapy, the patient's lymphoma has been in a state of complete response, and his GI symptoms have improved with a GFD. This case suggests that the possibility of CD and its association with intestinal NHL should be kept in mind, even in Asian populations.
authors.affiliation: The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Makishima
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ito
authors.forename: Ryo
authors.initials: R
authors.lastname: Kodama
authors.forename: Naoko
authors.initials: N
authors.lastname: Asano
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nakazawa
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Taiji
authors.initials: T
authors.lastname: Akamatsu
authors.forename: Kendo
authors.initials: K
authors.lastname: Kiyosawa
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ishida
mesh_terms: D000368:Aged; D002446:Celiac Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D007564:Japan; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D012074:Remission Induction