Complete donor chimaerism of Langerhans cells in lymph node early after allogeneic bone marrow transplantation.
Host-derived Langerhans cells (LCs) are crucial antigen-presenting cells that cause graft-vs.-host disease after allogeneic haematopoietic stem cell transplantation (HSCT). However, chimaerism of LCs after allogeneic HSCT is largely unknown in humans. We here report a case that developed dermatopathic lymphadenitis accompanied by an accumulation of donor-derived LCs in the second month after allogeneic HSCT with reduced-intensity conditioning. This is the first case to show that donor LCs have the ability to migrate into draining lymph nodes and replace host LCs early after HSCT in humans.
Ikeda
Kazuhiko
K
First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan.
Shichishima
Tsutomu
T
Teshima
Takanori
T
Ogawa
Kazuei
K
Nakamura-Shichishima
Akiko
A
Tajima
Hiroko
H
Noji
Hideyoshi
H
Hashimoto
Yuko
Y
Takeyama
Kunihiko
K
Ishibashi
Toshiyuki
T
Ohto
Hitoshi
H
Abe
Masafumi
M
Maruyama
Yukio
Y
D000328:Adult; D016026:Bone Marrow Transplantation; D002465:Cell Movement; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D008198:Lymph Nodes / Q000166:cytology*; D008199:Lymphadenitis / Q000209:etiology; D008297:Male; D018183:Transplantation Chimera; D014184:Transplantation, Homologous