Harnessing the immune system against human glioma.
Our studies are directed toward immune resistance to glial tumors, particularly in children. Initial experiments indicate that it is possible to boost both innate natural killer T lymphocytes and adaptive CD4+ and CD8+ T cells by targeting the appropriate antigens to dendritic cells. Our hypothesis is that optimal vaccination approaches against cancer will need to recruit both innate and adaptive defense mechanisms.
Dhodapkar
Kavita M
KM
The Rockefeller University, Laboratory of Cellular Physiology & Immunology, 1230 York Ave., New York, NY 10021, USA. dhodapk@mail.rockefeller.edu
Banerjee
Devi
D
Steinman
Ralph M
RM
D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D019496:Cancer Vaccines / Q000627:therapeutic use*; D005910:Glioma / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate
D019496:Cancer Vaccines