Recurrent childhood anaplastic large cell lymphoma: a retrospective analysis of registered cases in Japan.
This report presents a retrospective study of 26 Japanese children with recurrent anaplastic large cell lymphoma. The first relapses were documented at a median of 10.5 months after the initial diagnosis. Twenty-four patients achieved a second remission. After a median follow-up period of 47 months, 18 patients are still alive: 15 patients are in second complete remission (CR), three patients are in third CR or later. The 5 year overall and relapse-free survival rates were 61 +/- 12% and 51 +/- 12% respectively. The patients who received allogeneic haematopoietic stem cell transplantation during second CR showed a superior outcome to other patients.
Mori
Tetsuya
T
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan. morite@sc.itc.keio.ac.jp
Takimoto
Tetsuya
T
Katano
Naoyuki
N
Kikuchi
Akira
A
Tabuchi
Ken
K
Kobayashi
Ryoji
R
Ayukawa
Hiroshi
H
Kumagai
Masa-aki
MA
Horibe
Keizo
K
Tsurusawa
Masahito
M
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007564:Japan; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate; D014184:Transplantation, Homologous; D016896:Treatment Outcome