title: Management of fulminating ulcerative colitis in childhood with chimeric anti-CD25 antibody.
abstract: Fulminating acute ulcerative colitis (UC) is a potentially life threatening medical emergency. Up to 30% of individuals respond poorly to corticosteroids alone and second line medical or surgical therapies are indicated. We describe the successful use of chimeric anti-CD25 therapy in 4 such children poorly responsive to combined therapy with intravenous steroids and calcineurin inhibitors with a pretreatment predictive risk of colectomy of 85-100%. Clinical disease activity scores normalized within 72 hours of anti-CD25 administration and colonic histology provided evidence of mucosal healing within 10-14 days. None required emergency colectomy. Anti-CD25 is efficacious in fulminating UC and randomized placebo controlled trials appear indicated.
authors.affiliation: University Hospital Mannheim, Karl-Ruprecht-University of Heidelberg, Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schwarzer
authors.forename: I
authors.initials: I
authors.lastname: Ricciardelli
authors.forename: S
authors.initials: S
authors.lastname: Kirkham
authors.forename: K
authors.initials: K
authors.lastname: Binnie
authors.forename: N
authors.initials: N
authors.lastname: Shah
authors.forename: M A
authors.initials: MA
authors.lastname: Elawad
authors.forename: S M
authors.initials: SM
authors.lastname: Hill
authors.forename: M
authors.initials: M
authors.lastname: Furman
authors.forename: V V
authors.initials: VV
authors.lastname: Smith
authors.forename: N
authors.initials: N
authors.lastname: Sebire
authors.forename: P J
authors.initials: PJ
authors.lastname: Milla
authors.forename: M
authors.initials: M
authors.lastname: Londei
authors.forename: K J
authors.initials: KJ
authors.lastname: Lindley
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D065095:Calcineurin Inhibitors; D002648:Child; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000888:Antibodies, Anti-Idiotypic; D065095:Calcineurin Inhibitors; D015375:Receptors, Interleukin-2