title: Heterotopic pregnancy following ovulation induction by clomiphene citrate and timed intercourse: a case report.
abstract: We report a combined intra-uterine and unruptured tubal pregnancy following ovulation induction by clomiphene citrate (CC) and timed intercourse. The diagnosis of heterotopic pregnancy (HP) is the major problem until occurrence of tubal rupture. Because HP is a life-threatening condition, the diagnosis should be made as soon as possible. In a spontaneous conception, HP is a rare event. The risk of HP significantly increases after ovulation induction. Clomiphene itself could be associated with a high HP rate. We present a case with normally developing intra-uterine singleton pregnancy successfully managed by salpingectomy of synchronous tubal pregnancy following ovulation induction by CC and a review of the literature.
authors.affiliation: Department of Obstetrics and Gynecology, Göztepe Research and Training Hospital, Istanbul, Turkey. mmuratnaki@yahoo.com
authors.forename: M Murat
authors.initials: MM
authors.lastname: Naki
authors.forename: Cevahir
authors.initials: C
authors.lastname: Tekcan
authors.forename: Arzu
authors.initials: A
authors.lastname: Uysal
authors.forename: Kadir
authors.initials: K
authors.lastname: Güzin
authors.forename: Neşe
authors.initials: N
authors.lastname: Yücel
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000009:adverse effects*; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects*; D006801:Humans; D010062:Ovulation Induction / Q000009:adverse effects* / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D011274:Pregnancy, Tubal / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene