Elevation of serum creatine kinase in response to medical treatment of Graves' disease in children.
We describe two cases of increases in serum creatine kinase (CK) concentrations in children undergoing treatment of Graves' disease with antithyroid medications. Presenting complaints consisted of myalgias and muscle cramping in both patients, and increases in serum CK levels were noted 1 mo after initiation of antithyroid drugs. Both patients were euthyroid at the time of CK elevation. While the mechanisms for this process are not clear, it is likely that the acute decrease of thyroid hormones in tissues following a state of chronic hyperthyroidism may result in relative hypothyroid states and subsequent alterations in CK concentrations.


CONCLUSIONS
Although this side effect has been reported in adults, it is a novel finding in children. Clinicians should be aware of the rare potential for elevations in serum CK when initiating treatment for Graves' disease in children.
Mizuno
Haruo
H
Department of Paediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. hamizuno@med.nagoya-cu.ac.jp
Sugiyama
Yukari
Y
Nishi
Yoshikazu
Y
Ueda
Noriko
N
Ohro
Yoichiro
Y
Togari
Hajime
H
D000293:Adolescent; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003402:Creatine Kinase / Q000097:blood* / Q000378:metabolism; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use
D013956:Antithyroid Agents; D008713:Methimazole; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase