Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.
[reaction: see text]. An efficient resolution of methyl nonactate is reported by biotransformation in shake flask cultures of Rhodococcus erythropolis. The equilibrium of the reaction redox system can be manipulated by switching from aerobic to anaerobic growth, thereby generating both enantiomers of the target in excellent yield and enantiomeric purity.
Nikodinovic
Jasmina
J
Department of Chemistry, University of Montana, Missoula, Montana 59812, USA.
Dinges
Jennifer M
JM
Bergmeier
Stephen C
SC
McMills
Mark C
MC
Wright
Dennis L
DL
Priestley
Nigel D
ND
D000332:Aerobiosis; D000693:Anaerobiosis; D005663:Furans / Q000737:chemistry* / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012240:Rhodococcus / Q000378:metabolism*; D013237:Stereoisomerism
D005663:Furans; D018942:Macrolides; C514123:methyl nonactate; C050476:nonactin