title: Comparative study of perinatal outcome of dichorionic and trichorionic iatrogenic triplets.
abstract: OBJECTIVE
  The purpose of this study was to compare the perinatal outcome of dichorionic and trichorionic triplets who were conceived by assisted reproductive techniques.
  
  
  METHODS
  In this retrospective study, the maternal, neonatal, and chorionicity data were collected from 106 sets of trichorionic triamniotic and 34 sets of dichorionic triamniotic triplet pregnancies who were conceived by assisted reproductive techniques between January 1986 and December 2000. Perinatal and neonatal data were evaluated in relation to chorionicity and intertriplet birth weight discordance.
  
  
  RESULTS
  The dichorionic triamniotic triplets have an 8-fold higher risk of perinatal death than trichorionic triamniotic gestations (odds ratio, 7.9; 95% CI, 4.4-14.0; P < .001). This is attributed to a higher risk of very low birth weight (P < .01), delivery at < 30 weeks of gestation (P < .001), and premature rupture of membrane (P < .001) in dichorionic triamniotic triplets compared with trichorionic triamniotic pregnancies. Twin-twin transfusion syndrome (odds ratio, 11.5; 95% CI, 4.8-27.7; P < .001), delivery at < 30 weeks of gestation (odds ratio, 40.5; 95% CI, 16.9-97; P < .01), premature rupture of membrane (odds ratio, 6.7; 95% CI, 3.8-11.9; P < .01), and nulliparity (odds ratio, 3.1; 95% CI, 1.6-6.1; P < .05) had independent effects on perinatal loss rate.
  
  
  CONCLUSIONS
  The dichorionic triplets have an 8 times higher perinatal mortality rate than trichorionic triamniotic pregnancies.
authors.affiliation: Department of Obstetrics, University of Manchester, St Mary's Hospital, Manchester, United Kingdom.
authors.forename: Rekha
authors.initials: R
authors.lastname: Bajoria
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Ward
authors.forename: Adedayo L
authors.initials: AL
authors.lastname: Adegbite
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D005307:Fertilization in Vitro; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D005330:Fetofetal Transfusion / Q000453:epidemiology; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D016015:Logistic Models; D015999:Multivariate Analysis; D010062:Ovulation Induction; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D012189:Retrospective Studies; D014310:Triplets; D014427:Twins