title: Study on the pathogenic mechanism of Broca's and Wernicke's aphasia.
abstract: OBJECTIVE
  To study the mechanisms of aphasia by observing cerebral blood flow and metabolism changes in language functional areas of the brain using imaging, in order to develop a language rehabilitation plan for aphasia patients.
  
  
  METHODS
  Fifty-eight patients who suffered from Broca's or Wernicke's aphasia secondly to cerebral infarction were evaluated using the Western aphasia battery and Frenchay dysarthria assessment. CT and MRI were obtained to identify the location of lesions, and the language areas were analysed with magnetic resonance spectroscopy (MRS) and perfusion-weighted imaging (PWI). The results were compared with those of the contralateral hemisphere.
  
  
  RESULTS
  Of the 58 patients, there were 23 Broca's aphasia patients, 29 Wernicke's aphasia patients and six other aphasia types. We excluded five patients accompanied by dysarthria, six patients with other aphasia types and 14 patients with much more disease lesions. Finally, we analysed the remaining 12 Broca's aphasia and 21 Wernicke's aphasia patients by MRS and PWI. MRS shows that the N-acetylaspartate, choline and creatine of the Broca's or Wernicke's area were reduced than those of the contralateral hemisphere, while PWI results show that the damaged Broca's or Wernicke's areas were in a hypoperfusion state.
  
  
  CONCLUSIONS
  Broca's or Wernicke's area of aphasia patients exhibits hypoperfusion and hypometabolism, indicating that they might be the mechanisms of Broca's or Wernicke's aphasia.
authors.affiliation: Department of Neurology of Beijing Tiantan Hospital, affiliated with Capital University of Medical Sciences, China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiping
authors.initials: X
authors.lastname: Gong
authors.forename: Xuejin
authors.initials: X
authors.lastname: Sun
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D001039:Aphasia, Broca / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D001041:Aphasia, Wernicke / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010100:Oxygen / Q000097:blood; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003401:Creatine; D010100:Oxygen