title: [Lymph node sentinel in gastric carcinoma: proposal of a multicenter GISCRIS (Gruppo Italiano per lo Studio della Chirurgia Radioguidata e dell'immunoscintigrafia) protocol].
abstract: Sentinel node biopsy has been widely adopted in the treatment of cutaneous melanoma and breast cancer. The ongoing controversy concerning the extension of lymphatic dissection in gastric cancer demonstrate that the optimal extent of lymphadenectomy has yet to be established, and underlines that the research in this area is needed to refine our knowledge and consequently our treatment of gastric tumors. In this paper the authors describe a multicentric protocol concerning the sentinel node research in early and advanced T1-T2 gastric cancer employing the blue dye method and lymphoscintigraphy by means of the endoscopic injection of Tc99m labeled nanocolloids. The aim of this protocol is to assess the clinical relevance of the sentinel node biopsy in selecting N+ patients in early gastric cancer, and the role of the same technique in detecting N2 positive patients in case of advanced gastric cancer. Assuming a confidence interval of +/- 5%, a sample of 100 recruited cases over three years is previewed.
authors.affiliation: SC Chirurgia Oncologica, ASO S Giovanni Battista, Università degli Studi, Torino.
authors.forename: S
authors.initials: S
authors.lastname: Sandrucci
authors.forename: E
authors.initials: E
authors.lastname: Luccisano
authors.forename: A
authors.initials: A
authors.lastname: Filomena
authors.forename: G
authors.initials: G
authors.lastname: Verdecchia
authors.forename: A
authors.initials: A
authors.lastname: Mussa
mesh_terms: D002985:Clinical Protocols; D006801:Humans; D015337:Multicenter Studies as Topic; D021701:Sentinel Lymph Node Biopsy; D013274:Stomach Neoplasms / Q000473:pathology*