Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters.
OBJECTIVE
The objective of this study was to investigate the effective dose of plant sterol ester (PSE)-enriched diacylglycerol (DAG) oil for healthy subjects with mild hypercholesterolemia.


METHODS
A randomized, placebo-controlled, double-blind, parallel study was performed in patients with mild hypercholesterolemia; 0.0, 0.3, 0.4, and 0.5 g of PSE was dissolved in 15 g of a DAG-containing mayonnaise-type product; and 15 g/d of the product was administered 4 wk.


RESULTS
Total serum cholesterol levels were significantly decreased as a result of the ingestion of at least 0.4 g/d of PSE, and serum low-density lipoprotein cholesterol levels were significantly decreased by the ingestion of at least 0.3 g/d of PSE.


CONCLUSIONS
Daily ingestion of 15 g of DAG plus mayonnaise containing at least 0.4 g/d of PSE for 4 wk may significantly decrease cholesterol.
Saito
Shinichiro
S
Health Care Products Research Laboratories No. 1, Kao Corporation, Tokyo, Japan.
Takeshita
Masao
M
Tomonobu
Kazuichi
K
Kudo
Naoto
N
Shiiba
Daisuke
D
Hase
Tadashi
T
Tokimitsu
Ichiro
I
Yasukawa
Takuji
T
D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004075:Diglycerides / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004952:Esters; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008297:Male; D010840:Phytosterols / Q000627:therapeutic use*; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004075:Diglycerides; D004952:Esters; D010840:Phytosterols; D002784:Cholesterol