Bacterial biofilm inhibitors from Diospyros dendo.
One new (1) and four known (2-5) ursene triterpenes with potent inhibition of the formation of the bacterial biofilm Pseudomonas aeruginosa PA01 were obtained from Diospyros dendo using a high-throughput natural products chemistry procedure. These compounds were isolated as mass-limited samples. The miniaturization of the structure elucidation and dereplication was performed primarily utilizing a capillary-scale NMR probe.
Hu
Jin-Feng
JF
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 11199 Sorrento Valley Road, Suite H, San Diego, California 92121, USA. jhu@sequoiasciences.com
Garo
Eliane
E
Goering
Matt G
MG
Pasmore
Mark
M
Yoo
Hye-Dong
HD
Esser
Tim
T
Sestrich
Jennifer
J
Cremin
Peadar A
PA
Hough
Grayson W
GW
Perrone
Peter
P
Lee
Yin-Shi L
YS
Le
Ngoc-Tram
NT
O'Neil-Johnson
Mark
M
Costerton
John W
JW
Eldridge
Gary R
GR
D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D029788:Diospyros / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C508541:3-O-cis-p-coumaroyl-20-hydroxy-12-ursen-28-oic acid; D014315:Triterpenes