title: Cortistatin-17 and somatostatin-14 display the same effects on growth hormone, prolactin, and insulin secretion in patients with acromegaly or prolactinoma.
abstract: BACKGROUND
  Cortistatin binds all somatostatin receptor subtypes but also has particular central actions; moreover, a specific cortistatin receptor has also been discovered.
  
  
  OBJECTIVE
  We compared the endocrine effects of cortistatin-17 with those of somatostatin-14 in patients with acromegaly (ACRO) or prolactinoma (PRLOMA). Normal subjects (NS) were studied as control group.
  
  
  METHODS
  All subjects underwent the following tests: 1) saline, 2) somatostatin-14 (2.0 microg/kg.h iv, 0-120 min) and 3) cortistatin-17 (2.0 microg/kg.h iv, 0-120 min) infusion.
  
  
  RESULTS
  Cortistatin-17 and somatostatin-14 inhibited GH secretion to the same extent in ACRO (P < 0.05) and NS (P < 0.01). Cortistatin-17 and somatostatin-14 inhibited PRL secretion in PRLOMA (P < 0.05), to some extent in ACRO (P value not significant), but not in NS. Insulin secretion was inhibited by both cortistatin-17 and somatostatin-14 to the same extent in all groups (P < 0.05).
  
  
  CONCLUSIONS
  Cortistatin-17 and somatostatin-14 display the same effects on GH, PRL, and insulin secretion in patients with ACRO or PRLOMA.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, San Giovanni Battista-Molinette Hospital, Corso Dogliotti 14, 10126 Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Grottoli
authors.forename: V
authors.initials: V
authors.lastname: Gasco
authors.forename: F
authors.initials: F
authors.lastname: Broglio
authors.forename: R
authors.initials: R
authors.lastname: Baldelli
authors.forename: F
authors.initials: F
authors.lastname: Ragazzoni
authors.forename: F
authors.initials: F
authors.lastname: Gallenca
authors.forename: A
authors.initials: A
authors.lastname: Mainolfi
authors.forename: F
authors.initials: F
authors.lastname: Prodam
authors.forename: G
authors.initials: G
authors.lastname: Muccioli
authors.forename: E
authors.initials: E
authors.lastname: Ghigo
mesh_terms: D000172:Acromegaly / Q000097:blood*; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002352:Carrier Proteins / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005949:Glucose Oxidase / Q000378:metabolism; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000009:adverse effects / Q000494:pharmacology; D010911:Pituitary Neoplasms / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D015175:Prolactinoma / Q000097:blood*; D013004:Somatostatin / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; C105172:CORT protein, human; D002352:Carrier Proteins; D007328:Insulin; D009479:Neuropeptides; D019382:Human Growth Hormone; D013004:Somatostatin; D011388:Prolactin; D005949:Glucose Oxidase