title: Recent advances in combinatorial chemistry applied to development of anti-HIV drugs.
abstract: A compilation of combinatorial chemistry techniques applied to anti-HIV drug development is presented in this review. This synthetic strategy together with high throughput screening assays has allowed the discovery and optimization of novel lead anti-HIV compounds.
authors.affiliation: Grup d'Enginyeria Molecular, GEM, Institut Químic de Sarriá, IQS, Universitat Ramon Llull, Vía Augusta 390, E-08017 Barcelona, Spain. j.teixido@iqs.url.edu
authors.forename: S
authors.initials: S
authors.lastname: Pettersson
authors.forename: I
authors.initials: I
authors.lastname: Clotet-Codina
authors.forename: J A
authors.initials: JA
authors.lastname: Esté
authors.forename: J I
authors.initials: JI
authors.lastname: Borrell
authors.forename: J
authors.initials: J
authors.lastname: Teixidó
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006678:HIV / Q000187:drug effects / Q000502:physiology; D023581:HIV Fusion Inhibitors / Q000138:chemical synthesis; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis; D006801:Humans; D015394:Molecular Structure; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis
chemical_list: D019380:Anti-HIV Agents; D023581:HIV Fusion Inhibitors; D019428:HIV Integrase Inhibitors; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors