title: Isolation and characterization of a novel small cardioactive peptide-related peptide from the brain of Octopus vulgaris.
abstract: A novel small cardioactive peptide (SCP)-related peptide (oct-SCPRP: Ser-Asn-Gly-Tyr-Leu-Ala-Leu-Pro-Arg-Gln-NH2) was isolated from the brain of the octopus (Octopus vulgaris). cDNA encoding this precursor protein was cloned. Oct-SCPRP was shown to evoke contraction in the radula protractor muscle, and the precursor protein was highly homologous to the SCP family in the Mollusk but did not encode a related peptide, SCPB. The expression of oct-SCPRP mRNA was present not only in the peripheral nervous system (PNS) which is a motor center for the control of feeding, but also in the central nervous system (CNS) which is capable of complex analysis, learning, and controls behaviors.
authors.affiliation: Suntory Institute for Bioorganic Research, 1-1-1 Wakayamadai, Shimamoto, Mishima, Osaka 618-8503, Japan.
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Kanda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Minakata
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D008969:Molecular Sequence Data; D008974:Mollusca / Q000378:metabolism; D009119:Muscle Contraction; D009479:Neuropeptides / Q000737:chemistry*; D049831:Octopodiformes / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
chemical_list: D018076:DNA, Complementary; D009479:Neuropeptides; D010455:Peptides