Elevated total and isoenzyme forms of acid phosphatase in falciparum malaria.
The activities of total serum acid phosphatase (E.C. 3.1.3.2) and of two of its isoenzymes, tartrate-resistant acid phosphatase and erythrocyte-specific acid phosphatase were measured in 109 adult male and female patients presenting acute falciparum malaria infection, and a normal, healthy control group comprised of 82 subjects. All the three forms of acid phosphatase were found to be significantly (p<0.05) higher during infection as compared to their activity in the control group. This result suggests that the measurement of acid phosphatase, particularly the erythrocyte isoenzyme, in serum could be potentially used as a biomarker of acute falciparum malaria infection.
Garba
Ibrahim H
IH
Chemistry Programme, School of Science, Abubakar Tafawa Balewa University, PMB 0248 Bauchi, Nigeria. ihgarba2002@yahoo.com
Gatsing
Donatien
D
Ubom
Gregory
G
D000135:Acid Phosphatase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D016778:Malaria, Falciparum / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009549:Nigeria
D007527:Isoenzymes; D000135:Acid Phosphatase