title: Fertility preservation in female oncology patients.
abstract: Survival rates for patients treated for the majority of childhood and young adult cancers have improved dramatically in recent years. Despite the high probability of survival, and often good quality of life in female survivors, until recently the concept of fertility preservation has not been seen to be an important component of the overall management of these patients. Over the last few years, various protection and preservation strategies have been developed, which may address potential reproductive concerns. Gametes or embryos may be frozen prior to potentially gonadotoxic cancer therapy, and ovarian tissue may be frozen and stored, with several pregnancies described after subsequent grafting. There is also increasing interest in the possibility of ovarian protection using gonadotrophin-releasing hormone analogues during chemotherapy, despite the lack of randomised controlled trials. Additionally, there are reports of novel protective strategies, including therapeutic alteration or manipulation of the sphingomyelin pathways. This review summarises methods of fertility protection and preservation currently available, as well as the emergence of promising new strategies.
authors.affiliation: Reproductive Services and Melbourne IVF, The Royal Women's Hospital, Melbourne, Australia. kate.stern@mivf.com.au
authors.forename: Catharyn J
authors.initials: CJ
authors.lastname: Stern
authors.forename: Manuela G
authors.initials: MG
authors.lastname: Toledo
authors.forename: Debra A
authors.initials: DA
authors.lastname: Gook
authors.forename: John F
authors.initials: JF
authors.lastname: Seymour
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000628:therapy; D002648:Child; D015925:Cryopreservation / Q000639:trends; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000517:prevention & control*; D011788:Quality of Life; D012099:Reproductive Techniques / Q000639:trends*; D012509:Sarcoma / Q000628:therapy; D017741:Survivors