title: Histological classification of liver fibrosis and its impact on the postoperative clinical course of patients with congenital dilatation of the bile duct.
abstract: OBJECTIVE
  Infants and children with congenital dilatation of the bile duct (CDBD) usually also have some degree of liver fibrosis, which occasionally persists after diversion surgery, leading to liver cirrhosis. We conducted this study to evaluate the histological degree of liver fibrosis using intraoperative biopsy and to determine whether it affects the postoperative clinical course.
  
  
  METHODS
  The subjects were 43 infants and children with CDBD. The age at operation ranged from 1 month to 14 years. Histological classification was defined as follows: grade 0, no fibrosis; grade 1, fibrosis confined to the portal area; grade 2, bridge formation with the neighboring portal area; grade 3, widened bridging fibrosis; and grade 4, pseudolobule formation, representative of cirrhosis.
  
  
  RESULTS
  There were 21 (48.8%) patients with grade 0, 17 (39.5%) with grade 1, 4 (9.3%) with grade 2, 1 (2.3%) with grade 3, and 0 (0%) with grade 4 fibrosis. There were no differences in preoperative serum total bilirubin, total bile acid, aspartate aminotransferase, or gamma-glutamyl transpeptidase levels among the four groups. On the other hand, the grade 2 and 3 groups tended to include patients with a lower age at operation, and lower amylase levels in the serum and bile. Postoperatively, clinical symptoms resolved and laboratory data normalized in all patients. Two patients underwent liver biopsy for other reasons 3 and 4 years after surgery, which confirmed disappearance of the liver fibrosis. These patients had originally had grade 1 and grade 2 fibrosis, respectively.
  
  
  CONCLUSIONS
  Mild to moderate liver fibrosis is present in almost half of all children with CDBD; however, if it is graded as less than moderate, it will probably not affect the postoperative clinical course.
authors.affiliation: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, D-6 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Kimura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ihara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fukuzawa
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001649:Bile Duct Diseases / Q000150:complications* / Q000151:congenital* / Q000601:surgery; D001652:Bile Ducts / Q000002:abnormalities*; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007430:Intraoperative Care / Q000379:methods; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D011183:Postoperative Complications / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D016896:Treatment Outcome