Bioinert solution-cross-linked hydrogen-bonded multilayers on colloidal particles.
Bioinert polyelectrolyte multilayers comprised of poly(acrylic acid) and polyacrylamide were deposited on colloidal particles (1.7 microm in diameter) at low pH conditions by layer-by-layer assembly using hydrogen-bonding interactions. The multilayer films were coated uniformly on the colloidal particles without causing any flocculation of the colloids, and the deposited films were subsequently cross-linked by a single treatment of a carbodiimide aqueous solution. The lightly cross-linked multilayer films show excellent stability at physiological conditions (pH 7.4, phosphate-buffered saline), whereas untreated multilayer films dissolved. The multilayer-coated surfaces, both on flat substrates and on colloidal particles, exhibit excellent resistance toward mammalian cell adhesion. With this new solution-based cross-linking method, bioinert H-bonded multilayer coatings offer potential for biomedical applications.
Yang
Sung Yun
SY
Department of Materials Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Lee
Daeyeon
D
Cohen
Robert E
RE
Rubner
Michael F
MF
D000180:Acrylic Resins / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry*; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D010316:Particle Size; D012996:Solutions / Q000737:chemistry; D014867:Water / Q000737:chemistry; D000099166:Polyacrylamides
D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D003102:Colloids; D004573:Electrolytes; D008567:Membranes, Artificial; D012996:Solutions; D014867:Water; D000099166:Polyacrylamides; C006903:carbopol 940