title: Enhancing the bioavailability of cyclosporine a using solid dispersion containing polyoxyethylene (40) stearate.
abstract: Solid dispersion containing polyoxyethylene (40) stearate and cyclosporine A was prepared by solvent-melt method and characterized using differential scanning calorimetry, powder X-ray diffraction, and Infrared Fourier Transform Spectroscopy (FTIR). Dissolution of the drug from solid dispersion was dramatically enhanced compared to that from the drug powder alone and physical mixture. In vivo oral bioavailability of cyclosporine A from the solid dispersion in Wistar rats was comparable to that from a commercial product, Sandimmun Neoral (P>0.05). The formulation is stable up to six months under 30 degrees C/RH60% and one year at 25 degrees C/RH 60% when packed in aluminum-polyethylene laminated bags.
authors.affiliation: Department of Pharmaceutics, School of pharmacy, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Junhua
authors.initials: J
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
authors.forename: Yuanxing
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tiankun
authors.initials: T
authors.lastname: Gao
authors.forename: Yuanying
authors.initials: Y
authors.lastname: Pei
mesh_terms: D000818:Animals; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D016572:Cyclosporine / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D004355:Drug Stability; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical; D014961:X-Ray Diffraction
chemical_list: D011092:Polyethylene Glycols; D016572:Cyclosporine