[Integrated treatment of peritoneal carcinomatosis: preliminary experience].
A prospective study has been carried on 37 patients, 35 of them affected by peritoneal carcinomatosis from ovarian (16), appendiceal (7), colorectal (5), mesothelial (4), gastric (3) primary and 2 affected by sarcomatosis. Mean PCI was 22 (median, 22). Eighty-five percent of the patients presented debilitating ascites associated in 23% to initial symptoms of intestinal obstruction. All the patients have been treated with peritonectomy and intraoperative hyperthermic chemoperfusion and CC 0-1 cytoreduction was achieved in 81%. Major morbidity and mortality was respectively 37.8% and 16.2%, where 5 out 6 deaths recorded in the first 19 months of our experience, representing our learning curve. At a median follow-up of 8 months (range, 1-54), 18 patients are alive and disease-free and 4 patients are alive with disease. Two-yr overall survival was 49.1% for all series. Difference in survival evaluating CC 0-1 vs CC 2 patients was statistically significant.
De Rosa
B
B
Azienda Ospedaliera San Camillo Forlanini, UOC di Chirurgia Generale Oncologica, Roma.
Valle
M
M
Cavaliere
F
F
Federici
O
O
Sperduti
I
I
Garofalo
A
A
D002277:Carcinoma / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D010534:Peritoneal Neoplasms / Q000628:therapy*; D011446:Prospective Studies