title: CNS tuberculosis: a longitudinal analysis of epidemiological and clinical features.
abstract: In a prospective Canadian cohort of 82 764 patients with tuberculosis (TB), the risk of developing central nervous system manifestations of TB (CNS-TB) (1%) was higher among younger, female, Aboriginal and foreign-born persons (P < 0.005), together with an elevated mortality risk (RR 4.23), compared to controls with only pulmonary TB. TB detection was lower in the CNS-TB group (P < 0.005), while the likelihood of being cured was also reduced (P < 0.005). CNS-TB remains a serious complication of TB in the industrialised world.
authors.affiliation: Tuberculosis Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada. Melissa_Phypers@hc-sc.gc.ca
authors.forename: M
authors.initials: M
authors.lastname: Phypers
authors.forename: T
authors.initials: T
authors.lastname: Harris
authors.forename: C
authors.initials: C
authors.lastname: Power
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004641:Emigration and Immigration; D005260:Female; D006801:Humans; D007223:Infant; D004930:Inuit; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020306:Tuberculosis, Central Nervous System / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology / Q000401:mortality; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology