Near infrared spectroscopy in brain injury: today's perspective.
The technique of near infrared spectroscopy (NIRS) is based on the principle of light attenuation by the chromophores oxyhaemoglobin (HbO2), deoxyhaemoglobin (Hb) and cytochrome oxidase. Changes in the detected light levels can therefore represent changes in concentrations of these chromophores. Clinical use of NIRS in the brain has been well established in neonates where transillumination is possible. While it has become a useful research tool for monitoring the adult brain, clinical application has been hampered by the fact that it must be applied in reflectance mode. This has resulted in a number of concerns, most significantly the issue of signal contamination by the extracranial tissue layers. Algorithms have been applied to try to overcome this problem, and techniques such as time resolved, phase resolved and spatially resolved spectroscopy have been developed. There has been renewed interest in NIRS as an easy to use, non-invasive technique for measuring tissue oxygenation in the adult brain. Recent technical advances have led to the development of compact, portable instruments that detect changes in optical attenuation of several wavelengths of light. Near infrared spectroscopy is an evolving technology that holds significant potential for technical advancement. In particular, NIRS shows future promise as a clinical tool for bedside cerebral blood flow measurements and as a cerebral imaging modality for mapping structure and function.
Al-Rawi
P G
PG
Academic Neurosurgery Unit, Addenbrooke's Hospital, Cambridge, UK. pga20@medschl.cam.ac.uk
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism*; D004867:Equipment Design; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods / Q000639:trends; D010092:Oximetry / Q000295:instrumentation* / Q000379:methods / Q000639:trends; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods* / Q000639:trends
D015415:Biomarkers; D006454:Hemoglobins; D010100:Oxygen