title: [HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing].
abstract: OBJECTIVE
  To investigate the gene polymorphism of human leukocyte antigen (HLA)-A, B, DRB1 loci in the population of Beijing region, and research on the application feasibility of polymerase chain reaction sequence-based typing (PCR-SBT) method.
  
  
  METHODS
  PCR-SBT method was applied to determine HLA- A, B, DRB1 genotypes of 618 unrelated healthy individuals of Beijing region.
  
  
  RESULTS
  A total of 84 different alleles and 199 genotypes of HLA-A, 143 alleles and 366 genotypes of HLA-B, 122 alleles and 286 genotypes of HLA-DRB1 were detected.
  
  
  CONCLUSIONS
  The results showed the characteristics of HLA-A, B, DRB1 distributions, and provided more comprehensive and accurate gene data that may serve as normal reference values for all of Beijing people.
authors.affiliation: Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, P.R.China.
authors.forename: Ya-jun
authors.initials: YJ
authors.lastname: Deng
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Dong-ying
authors.initials: DY
authors.lastname: Wu
authors.forename: Song-nian
authors.initials: SN
authors.lastname: Hu
authors.forename: Sheng-bin
authors.initials: SB
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Bo-feng
authors.initials: BF
authors.lastname: Zhu
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011153:Population
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains