title: Rapid generation of molecular complexity using "hybrid" multi-component reactions (MCRs): application to the synthesis of alpha-amino nitriles and 1,2-diamines.
abstract: Methyleneaziridines can be converted into a wide range of 1,2-diamines and 2-cyanopiperidines in a single operation with the formation of three intermolecular carbon-carbon bonds using a "hybrid" MCR.
authors.affiliation: Department of Chemistry, University of Warwick, Gibbert Hill Road, Coventry, UKCV4 7AL.
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Shiers
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Clarkson
authors.forename: Michael
authors.initials: M
authors.lastname: Shipman
authors.forename: Jerome F
authors.initials: JF
authors.lastname: Hayes
mesh_terms: D001388:Aziridines / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D003959:Diamines / Q000138:chemical synthesis*; D008697:Methane / Q000031:analogs & derivatives; D008956:Models, Chemical; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*
chemical_list: D001388:Aziridines; D003486:Cyanides; D003959:Diamines; D009570:Nitriles; D010880:Piperidines; D002244:Carbon; D008697:Methane