[Supramolecular nanocarrier for gene and siRNA delivery].
In this review article, supramolecular nanocarriers for gene and siRNA delivery were introduced. They were formed through the multimolecular assembly of block copolymers, containing the DNA or siRNA inside the core of the micelle structure. Due to the excellent stability under the physiological conditions, low toxic effect, and controllable gene functions, this system should be a promising candidate for in vivo therapeutic applications including the non-lethal diseases and the tissue engineering.
Itaka
Keiji
K
Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo.
Chung
Ung-Il
UI
Kataoka
Kazunori
K
D004247:DNA; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D008823:Micelles; D049329:Nanostructures; D034741:RNA, Small Interfering
D008823:Micelles; D034741:RNA, Small Interfering; D004247:DNA