title: Wortmannilactones A-D, 22-membered triene macrolides from Talaromyces wortmannii.
abstract: The fungus Talaromyces wortmannii, isolated from a soil sample collected in China's Yunnan province, produced four novel 22-membered macrolides, namely, wortmannilactones A-D (1-4). Structures 1-4 were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Compounds 1-4 exhibited in vitro cytotoxic activity against several human cancer cell lines with IC50 values ranging from 28.7 to 130.5 microM.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People's Republic of China.
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Dong
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Lin
authors.forename: Xiao
authors.initials: X
authors.lastname: Ren
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Xinhua
authors.initials: X
authors.lastname: Lu
authors.forename: Jiangong
authors.initials: J
authors.lastname: He
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032901:Talaromyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides