Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?
Lactate and H(+) are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers.
Connes
Philippe
P
EA 3596, Laboratoire ACTES, Université des Antilles et de la Guyane, Campus de Fouillole, 97159 Pointe-à-Pitre, Guadeloupe. pconnes@yahoo.fr
Sara
Fagnété
F
Hardy-Dessources
Marie-Dominique
MD
Etienne-Julan
Maryse
M
Hue
Olivier
O
D000293:Adolescent; D000328:Adult; D015153:Blotting, Western; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D004907:Erythrocyte Deformability / Q000502:physiology*; D004909:Erythrocyte Indices; D004913:Erythrocytes, Abnormal / Q000737:chemistry* / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D018056:Hemorheology; D006801:Humans; D008833:Microcirculation / Q000503:physiopathology; D027501:Monocarboxylic Acid Transporters / Q000032:analysis* / Q000502:physiology*; D012805:Sickle Cell Trait / Q000097:blood* / Q000503:physiopathology
D006454:Hemoglobins; D027501:Monocarboxylic Acid Transporters