title: Cerebral autoregulation is impaired in cardioinhibitory carotid sinus syndrome.
abstract: OBJECTIVE
  To compare changes in cerebral autoregulation in response to controlled, lower body negative pressure-induced hypotension in patients with carotid sinus syndrome (CSS) and case controls.
  
  
  METHODS
  Prospective case controlled study.
  
  
  METHODS
  Secondary and tertiary referral falls and syncope service.
  
  
  METHODS
  17 consecutive patients with CSS and 11 asymptomatic controls.
  
  
  METHODS
  Hypotension insufficient to cause syncope induced by lower body negative pressure (minimum 30 mm Hg fall in systolic blood pressure (SBP)) during concomitant transcranial Doppler ultrasonography.
  
  
  METHODS
  Cerebral autoregulation (systolic, diastolic and mean middle cerebral arterial blood flow velocities and cerebrovascular resistance) with continuous end-tidal carbon dioxide and haemodynamic monitoring.
  
  
  RESULTS
  Cerebral autoregulatory indices differed significantly between patients with CSS and controls. Systolic, diastolic and middle cerebral arterial blood flow velocities were, respectively, 9.2 m/s (95% confidence interval (CI) 2.9 to 15.4 m/s), 4.7 m/s (95% CI 1.5 to 7.9 m/s) and 6.9 m/s (95% CI 2.5 to 11.4 m/s) slower in patients with CSS. Cerebrovascular resistance was significantly greater in patients with CSS than in controls at SBP nadir and suction release; differences were 0.9 mm Hg/m/s (95% CI 0.0 to 1.7 mm Hg/m/s) and 0.8 mm Hg/m/s (95% CI 0.0 to 1.7 mm Hg/m/s), respectively. End-tidal carbon dioxide and systemic haemodynamic variables were similar for patients and controls at baseline and during lower body negative pressure.
  
  
  CONCLUSIONS
  Cerebral autoregulation is altered in patients with CSS. This difference may have aetiological implications in the differential presentation with falls and drop attacks rather than syncope.
authors.affiliation: Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK. steve.parry@nuth.northy.nhs.uk
authors.forename: S W
authors.initials: SW
authors.lastname: Parry
authors.forename: N
authors.initials: N
authors.lastname: Steen
authors.forename: M
authors.initials: M
authors.lastname: Baptist
authors.forename: K A
authors.initials: KA
authors.lastname: Fiaschi
authors.forename: O
authors.initials: O
authors.lastname: Parry
authors.forename: R A
authors.initials: RA
authors.lastname: Kenny
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology* / Q000503:physiopathology; D008150:Lower Body Negative Pressure; D008297:Male; D011446:Prospective Studies; D013575:Syncope / Q000209:etiology / Q000503:physiopathology*; D018667:Tilt-Table Test; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology