Evidence of reuptake inhibition responsible for mecamylamine-evoked increases in extracellular serotonin.
The present report using microdialysis approach investigates the neurochemical mechanism of mecamylamine in the regulation of extracellular serotonin in the dorsal raphe nucleus of freely behaving rats. These results suggest that mecamylamine may block serotonin reuptake, the effect consistent with its efficacy of antidepressant.
Ma
Zhiyuan
Z
Department of Biomedical Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
Pearson
Elliot
E
Isgor
Ceylan
C
Tao
Rui
R
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000157:Aconitine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D015283:Citalopram / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005110:Extracellular Space / Q000187:drug effects*; D008464:Mecamylamine / Q000494:pharmacology*; D017551:Microdialysis / Q000379:methods; D018733:Nicotinic Antagonists / Q000494:pharmacology; D011903:Raphe Nuclei / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D014851:Wakefulness
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000157:Aconitine; D015283:Citalopram; D008464:Mecamylamine; D018733:Nicotinic Antagonists; D012701:Serotonin; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors; C054634:methyllycaconitine