Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat.
Galanin (Gal) is a neuropeptide with supposed neurotrophic-like action. In the present study, expression of Gal has been investigated in the core and peri-infarct zone at 1, 4, 24 and 72 h after middle cerebral artery occlusion (MCAo) in the rat. Three days after MCAo a small but consistent number of morphological intact Gal-positive neuronal cells were observed in the peri-infarct zone. Gal-positive cells were barely detectable in the infarct and peri-infarct zone at 24 h. No Gal immunopositive cells were detected in brain subjected to 1 and 4 h of ischemia. Gal immunoreactivity was also detected in myelinated fibers 4 and 24 h after focal ischemia. Gal may be a peptide with neurotrophic and plasticity functions under stress conditions.
De Michele
Manuela
M
Department of Neuroscience, University La Sapienza, Viale Dell'Università, 30, 00185, Rome, Italy. manuela.demichele@uniroma1.it
Sancesario
Giuseppe
G
Toni
Danilo
D
Ciuffoli
Alessandro
A
Bernardi
Giorgio
G
Sette
Giuliano
G
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D002544:Cerebral Infarction / Q000378:metabolism* / Q000473:pathology; D019004:Galanin / Q000378:metabolism*; D007150:Immunohistochemistry; D020768:Middle Cerebral Artery / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D019004:Galanin