Amino acid derived macrocycles--an area driven by synthesis or application?
The synthesis, structure, and physical properties of macrocycles have fascinated chemists for many years. Their inherent properties make them useful in areas as diverse as ion transport across membranes, development of new antibiotics, and catalysis. In this Review, the authors examine the chemistry of macrocycles containing non-peptidic amino acid derived molecules; the analysis is discussed in terms of function, rather than structure or synthesis. It is revealed that the diverse and imaginative structures created by synthetic chemists are not being fully exploited in application-driven endeavors.
Gibson
Susan E
SE
Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AY, UK. s.gibson@imperial.ac.uk
Lecci
Cristina
C
D000596:Amino Acids / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
D000596:Amino Acids; D047028:Macrocyclic Compounds