title: Reversible Epstein-Barr virus-negative lymphadenopathy and bone marrow involved by Hodgkin's lymphoma in a rheumatoid arthritis patient undergoing long-term treatment with low-dose methotrexate: a case report and review of the literature.
abstract: We report a case of spontaneous regression of Epstein-Barr virus (EBV)-negative methotrexate-associated lymphadenopathy occurring with Hodgkin's lymphoma in the bone marrow of a 48-year-old woman with rheumatoid arthritis. Following 10 years of treatment with low-dose methotrexate, the patient developed pancytopenia, hypercalcemia, and elevated levels of liver enzymes over the course of 2 months. A computed tomography scan of the abdomen revealed splenomegaly and enlarged abdominal lymph nodes. A bone marrow biopsy demonstrated cellular marrow with 2 paratrabecular granuloma-like lesions composed of histiocytes, fibroblasts, small lymphocytes, a few plasma cells, and scattered CD30(+)CD15(+) Hodgkin's cells, including a classic Reed-Sternberg cell. The results of EBV studies of the bone marrow were negative. Within a month from withdrawal of methotrexate treatment, the patient's symptoms and the abnormalities in the laboratory results had regressed completely. A positron emission tomography scan failed to detect lymphadenopathy. Twelve months later, the patient remains free of symptoms.
authors.affiliation: Department of Pathology, University of Vermont College of Medicine, Burlington, USA. Annika.Svensson@hsc.utah.edu
authors.forename: Annika M
authors.initials: AM
authors.lastname: Svensson
authors.forename: Erica R
authors.initials: ER
authors.lastname: Jacobson
authors.forename: David
authors.initials: D
authors.lastname: Ospina
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Tindle
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001854:Bone Marrow Cells / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D016539:Reed-Sternberg Cells / Q000473:pathology; D013997:Time Factors
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate