Cell biology of the ghrelin receptor.
Ghrelin, a gastric peptide involved in growth hormone release and energy homeostasis, is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS-R1a), a G-protein coupled receptor mainly expressed in the pituitary and hypothalamus. This receptor mediates the main ghrelin-stimulated endocrine actions and some of the nonendocrine actions. However, a number of nonendocrine actions associated with ghrelin appear to be mediated by various GHS-R1a-related receptor subtypes, which are widely distributed in the central and peripheral tissues. This review summarises data concerning the localisation, regulation and function of GHS-R1a, as well as related receptors.
Camiña
J P
JP
Laboratory of Molecular Endocrinology, Research Area, Complexo Hospitalario Universitario de Santiago (CHUS), PO Box 563, E-15780 Santiago de Compostela, Spain. mecamina@usc.es
D000818:Animals; D030801:Animals, Genetically Modified; D004705:Endocytosis / Q000502:physiology; D005260:Female; D054439:Ghrelin; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D036361:Peptide Hormones / Q000502:physiology*; D011487:Protein Conformation; D021381:Protein Transport / Q000502:physiology; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D054440:Receptors, Ghrelin; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D054439:Ghrelin; D036361:Peptide Hormones; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D013006:Growth Hormone