title: Synthesis and preliminary biological evaluation of the 99mTc labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers.
abstract: 1-(3-1,2,4-Nitrotriazole-1-yl)-propanhydroxyiminoamide and 1-(6-nitrobenzoimidazole-1-yl)-propanhydroxyiminoamide were synthesized and radiolabeled with (99m)Tc. The (99m)Tc labeled complexes continuously accumulated in hypoxic murine sarcoma S180 cells in vitro but not in aerobic cells. Biodistribution results in mice bearing S180 tumor indicated that the tracers could localize in tumor and eliminate from it slowly. These results suggested that the (99m)Tc labeled nitrobenzoimidazole and nitrotriazole might be the novel tumor hypoxia markers.
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Taiwei
authors.initials: T
authors.lastname: Chu
authors.forename: Xuguang
authors.initials: X
authors.lastname: Gao
authors.forename: Xinqi
authors.initials: X
authors.lastname: Liu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.forename: Zhenquan
authors.initials: Z
authors.lastname: Guo
authors.forename: Xiangyun
authors.initials: X
authors.lastname: Wang
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D045744:Cell Line, Tumor; D007093:Imidazoles / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D015609:Organotechnetium Compounds / Q000737:chemistry*; D020005:Propanols / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: C511813:1-(3-1,2,4-nitrotriazole-1-yl)-propanhydroxyiminoamide; C511814:1-(6-nitrobenzoimidazole-1-yl)-propanhydroxyiminoamide; D000577:Amides; D014408:Biomarkers, Tumor; D007093:Imidazoles; D015609:Organotechnetium Compounds; D020005:Propanols; D014230:Triazoles