title: Distribution of 125I-labeled [2-8]-leucopyrokinin, active analog of leucopyrokinin in rats.
abstract: The brain and internal organs distribution of 125I-labeled [2-8]-leucopyrokinin ([2-8]-LPK), a truncated analog of leucopyrokinin (LPK), an insect myotropic peptide injected into the lateral brain ventricle was determined in rats. A high accumulation of this analog in adrenals and in the hypothalamus and hippocampus of the brain was found. A lesser but significant [2-8]-LPK accumulation in other internal organs and parts of the brain was also observed. The results of the present study confirm results of our previous study performed on the distribution of labeled native LPK in rats. A possible significance of obtained results for the brain function was discussed.
authors.affiliation: Department of Pharmacology, Medical Faculty in Zabrze, Medical University of Silesia, H. Jordana 38, PL 41-808 Zabrze, Poland. aplech@slam.katowice.pl
authors.forename: Andrzej
authors.initials: A
authors.lastname: Plech
authors.forename: Monika
authors.initials: M
authors.lastname: Rykaczewska-Czerwińska
authors.forename: Florian
authors.initials: F
authors.lastname: Ryszka
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Suszka-Switek
authors.forename: Barbara
authors.initials: B
authors.lastname: Dolińska
authors.forename: Danuta
authors.initials: D
authors.lastname: Konopińska
mesh_terms: D000818:Animals; D007276:Injections, Intraventricular; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011761:Pyrrolidonecarboxylic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D009842:Oligopeptides; C049557:leucopyrokinin; D011761:Pyrrolidonecarboxylic Acid