Non haematological effects of iron deficiency - a perspective.
Iron deficiency is a continuum beginning from lowering of tissue stores to the phase of exhausted tissue stores, interference with iron driven biochemical reactions in the body, microcytosis, hypochromia, increasing severity of anaemia with all its attendant consequences. Iron deficiency anaemia is a very well known concept but what is often not appreciated is the effect of broad canvas of iron deficiency on various tissues, organs and systems in our body in addition to iron deficiency anaemia leading to concept of "Iron deficiency disease". In this condition not only tissue delivery of oxygen is compromised but proliferation, growth, differentiation, myelinogenesis, immunofunction, energy metabolism, absorption and biotransformation are compromised leading to abnormal growth and behaviour, mental retardation, reduced cardiac performance and work efficiency, infection etc which ultimately leads to the concept that "iron deficiency not only breaks the machine but also wrecks the machinery."
Ghosh
Kanjaksha
K
Institute of Immunohaematology, KEM Hospital Campus, Parel, Mumbai - 400 012, India. kanjakshaghosh@hotmail.com.
D019069:Cell Respiration; D005260:Female; D006801:Humans; D007501:Iron / Q000502:physiology; D000090463:Iron Deficiencies; D019189:Iron Metabolism Disorders / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D010088:Oxidoreductases / Q000172:deficiency; D010100:Oxygen / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism; D011247:Pregnancy
D011166:Porphyrins; D007501:Iron; D010088:Oxidoreductases; D010100:Oxygen