[Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer].
OBJECTIVE
To investigate the association between methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of lung cancer.


METHODS
Totally 505 cases with lung cancer and 500 frequency-matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism methods. The odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression model. Haplotype frequency was estimated using EH software.


RESULTS
The frequency of the MTHFR C677T allele in cases was significantly higher than that in controls (53.5% vs 44.9%, P < 0.001). Compared with the 677CC genotype, the 677CT and 677TT genotypes were associated with increased risk of lung cancer, with the OR being 1.43 (95% CI, 1.04-1.95) and 2.40 (95% CI, 1.61-3.59), respectively. In addition, a significant difference in the distribution of haplotype frequencies between cases and controls was observed.


CONCLUSIONS
Functional polymorphism in MTHFR is associated with increased risk of lung cancer in Chinese population.
Zhang
Xue-mei
XM
Department of Etiology and Carcinogenesis, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
Miao
Xiao-ping
XP
Tan
Wen
W
Qu
Shi-ning
SN
Sun
Tong
T
Zhou
Yi-feng
YF
Lin
Dong-xin
DX
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk
D042965:Methylenetetrahydrofolate Reductase (NADPH2)