title: Pre-eclampsia is associated with sleep-disordered breathing and endothelial dysfunction.
abstract: Pre-eclamptic toxaemia (PET) may be associated with both endothelial dysfunction (ED) and sleep-disordered breathing (SDB). It was hypothesised that females with PET would demonstrate both SDB and ED, and that a correlation between these two would suggest a potential causative association. A total of 17 females with PET and 25 matched females with uncomplicated pregnancy were studied. They underwent a nocturnal ambulatory sleep study (using Watch_PAT100) and noninvasive evaluation of endothelial function utilising the reactive hyperaemia test (using Endo_PAT 2000). A higher ratio of post- to pre-occlusion pulse-wave amplitude (endothelial function index (EFI)) indicated better endothelial function. Females with PET had a significantly higher respiratory disturbance index (RDI) and lower EFI than controls (18.4+/-8.4 versus 8.3+/-1.3.h(-1), and 1.5+/-0.1 versus 1.8+/-0.1, respectively). Blood pressure significantly correlated with RDI and with EFI. EFI tended to correlate with RDI. In conclusion, these results suggest that both sleep-disordered breathing and endothelial dysfunction are more likely to occur in females with pre-eclamptic toxaemia than in females with uncomplicated pregnancies. The current authors speculate that respiratory disturbances contribute to the functional abnormality of the blood vessels seen in females with pre-eclamptic toxaemia, although causality cannot be determined based on this study.
authors.affiliation: Sleep laboratory, Rambam Medical Center and Technion - Israel Institute of Technology, Haifa, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Yinon
authors.forename: L
authors.initials: L
authors.lastname: Lowenstein
authors.forename: S
authors.initials: S
authors.lastname: Suraya
authors.forename: R
authors.initials: R
authors.lastname: Beloosesky
authors.forename: O
authors.initials: O
authors.lastname: Zmora
authors.forename: A
authors.initials: A
authors.lastname: Malhotra
authors.forename: G
authors.initials: G
authors.lastname: Pillar
mesh_terms: D000328:Adult; D001132:Arm / Q000098:blood supply; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017286:Polysomnography; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*