[Diagnosis of diseases by nanodevice].
I will describe the recent development of nanobiotechnologies based on the nanofabrication and molecular nanotechnology for diagnosis of diseases. The technologies allow us to develop novel methods to separate several biomolecules, including DNA, RNA, protein, peptide, polysaccharide, and glycoprotein towards the application in genomics, transcriptomics, proteomics, and glycoproteomics. The methods we have taken appear suitable for biomedical and clinical applications, including SNPs analysis, mutation analysis, haplotyping, DNA diagnosis, protein expression analysis, immunoassay, protein disease marker detection, point-of-care analysis, and future personalized medicine. The methods are also applicable to molecular imaging of cancer cell, cell diagnosis of cancer, and possible photodynamic therapy of cancer.
Baba
Yoshinobu
Y
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University.
D004252:DNA Mutational Analysis; D003933:Diagnosis; D006239:Haplotypes; D006801:Humans; D036103:Nanotechnology; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology; D020641:Polymorphism, Single Nucleotide