title: Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain.
abstract: ELMO is an upstream regulator of the Rho family small GTPase Rac. We investigated the distributions of mRNAs of two subtypes of ELMO, ELMO1 and ELMO2, in the developing mouse brain. Both ELMO1 and ELMO2 mRNAs are widely distributed in the developing mouse brain, but they were expressed in different neuronal populations in the cerebral cortex, thalamus, and cerebellum. Thus, ELMO1 and ELMO2 may play different roles during brain development.
authors.affiliation: Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan. hirokato@pharm.kyoto-u.ac.jp
authors.forename: Hironori
authors.initials: H
authors.lastname: Katoh
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Chisaki
authors.initials: C
authors.lastname: Ishida
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Manabu
authors.initials: M
authors.lastname: Negishi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D004622:Embryo, Mammalian; D015870:Gene Expression / Q000502:physiology; D017403:In Situ Hybridization / Q000379:methods; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; C510359:ELMO1 protein, mouse; D012333:RNA, Messenger