title: [Antibody response to Ascaris lumbricoides among the children population in the Ustí Region].
abstract: A group of 156 children aged between 10 and 12 years were screened for IgG and IgE antibodies to Ascaris lumbricoides. The study subjects were 64 children of Romany origin and 92 children from the majority population. IgG antibodies to Ascaris lumbricoides were detected in 112 (71.8%) children. No difference in the prevalence of IgG antibodies was found between Romany children and those from the majority population. As many as 34.1% of the study subjects had IgE antibodies to Ascaris lumbricoides, again with no difference between the two ethnic groups. Children with IgG antibodies to Ascaris lumbricoides had significantly higher total IgE levels compared to those who had tested IgG negative. To demonstrate induction of a non-specific IgE response was one of the study objectives. The high prevalence rates of IgG and IgE antibodies to Ascaris lumbricoides are suggestive of a high frequency of cross- and non-specific reactions. Possible effect of cross-reactivity to other antigens on the specific IgG and IgE antibody response to Ascaris lumbricoides is discussed.
authors.affiliation: Zdravotní ustav se sídlem v Ustí nad Labem. josef.richter@zuusti.cz
authors.forename: J
authors.initials: J
authors.lastname: Richter
authors.forename: I
authors.initials: I
authors.lastname: Stiborová
authors.forename: J
authors.initials: J
authors.lastname: Pohorská
authors.forename: L
authors.initials: L
authors.lastname: Dobiásová
authors.forename: V
authors.initials: V
authors.lastname: Král
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D001196:Ascariasis / Q000453:epidemiology* / Q000208:ethnology; D017164:Ascaris lumbricoides / Q000276:immunology*; D002648:Child; D018153:Czech Republic / Q000453:epidemiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D015995:Prevalence; D006178:Romani People; D016036:Seroepidemiologic Studies
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D007073:Immunoglobulin E