Primitive neuroectodermal tumor arising in the colon: report of a case.
Peripheral primitive neuroectodermal tumors (pPNETs) are usually found in the soft tissue of the extremities, paravertebral region, and chest wall. We report a rare case of a pPNET arising in the colon. A 59-year-old man underwent left hemicolectomy for an infiltrative ulcerating tumor, 11 cm long, in the descending colon. Histological examination of the resected specimen revealed small, round cell proliferation with rosette-like structures, and confirmed regional lymph node involvement and peritoneal dissemination near the primary tumor. Immunohistochemically, the tumor cells were positive for synaptophysin and MIC2 (CD 99). ESW-FLI1 chimeric mRNA was detected in the tumor by reverse transcriptase-polymerase chain reaction. The patient underwent resection of recurrence in the retroperitoneum 3 months later, but metastasis rapidly developed and he died of the disease 7 months after his first operation.
Kuwabara
Kouki
K
Department of Digestive Tract and General Surgery, Saitama Medical School, 1981 Kamoda, Tsujido-cho, Kawagoe, Saitama, 350-8550, Japan.
Ishida
Hideyuki
H
Shirakawa
Kazuo
K
Yokoyama
Masaru
M
Nakada
Hiroshi
H
Hayashi
Yoichi
Y
Hashimoto
Daijo
D
Miura
Ichiro
I
Itoyama
Shinji
S
Heike
Yuji
Y
D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery*; D018450:Disease Progression; D017809:Fatal Outcome; D052138:Genes, Neoplasm; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000601:surgery*; D012333:RNA, Messenger / Q000032:analysis; D035583:Rare Diseases; D012086:Reoperation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D012333:RNA, Messenger