Nitrones as therapeutics in age-related diseases.
Age-related diseases deprive individuals of a higher quality of life and therefore therapeutics for their treatment provide significant potential. An overview of the observations of nitrones as potential therapeutics in several age-related diseases is presented. Treatment of acute ischemic stroke is one condition where a nitrone (NXY-059) is in late phase 3 clinical trials now. Also presented is a summary of the most recent work we have accomplished on the anticancer activity of the nitrones in a hepatocellular carcinoma. The mechanistic basis of action of these compounds in several animal models is not yet understood at the molecular levels; however, it does appear clear that their anti-inflammatory properties are central to their action, which is based on their ability to down-regulate exacerbated signal transduction processes.
Floyd
Robert A
RA
Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D009369:Neoplasms / Q000188:drug therapy; D009589:Nitrogen Oxides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy
D009589:Nitrogen Oxides; C015388:nitrones