title: Reversible sirolimus-associated pneumonitis after heart transplantation.
abstract: Sirolimus (rapamycin) and everolimus are immunosuppressive agents that inhibit cardiac allograft vasculopathy. Sirolimus has been widely used in renal transplantation, and its use in heart transplantation is increasing. Sirolimus-associated pneumonitis has been described in renal transplant patients. Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation. Only 1 case has been described in detail, and this had a fatal outcome. Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.
authors.affiliation: Department of Transplantation, The Royal Brompton and Harefield NHS Trust, Harefield Hospital, Middlesex, United Kingdom.
authors.forename: Iman M
authors.initials: IM
authors.lastname: Hamour
authors.forename: Taurn K
authors.initials: TK
authors.lastname: Mittal
authors.forename: Alex D
authors.initials: AD
authors.lastname: Bell
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Banner
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000276:immunology; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects* / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D020123:Sirolimus