Solid-phase synthesis of 5'-deoxy-5'-amino-clitocine analogues.
Several 6-substituted-amino-5'-deoxy-5'-amino-clitocine analogues were synthesized in a parallel fashion in solid phase. The desired scaffold was generated by coupling 2,3-O-bis-(t-butyldimethylsilyl)-5-N-(monomethoxytrityl-polystyrene-resin)-1,5-diamino-5-deoxy-beta-D-ribofuranose and 4, 6-dichloro-5-nitropyrimidine. The scaffold was then reacted with a variety of amines to generate a small library of 14 analogues of 5'-deoxy-5'-amino-clitocine following a protocol developed earlier.
Varaprasad
Chamakura V N S
CV
Department of Medicinal Chemistry, Valeant Pharmaceuticals International, Inc., 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com
Habib
Qazi
Q
An
Haoyun
H
Hong
Zhi
Z
D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*
C448386:5'-deoxy-5'-amino-clitocine; D011741:Pyrimidine Nucleosides