Fatty acid cytotoxicity to organ-cultured bovine lenses.
High sensitivity of cultured bovine and human lens epithelial cells to unsaturated free fatty acids has been reported in previous papers. Here we show that micromolar concentrations of unsaturated free fatty acids also impair lens cells during organ culturing, a system which resembles the in vivo situation much better than cell cultures do. This added weight to the assumption that fatty acid cytotoxicity might be causally related to senile cataract as well as to cataracts associated with systemic diseases.
Glanz
Dagobert
D
Faculty of Medicine, Institute of Physiological Chemistry, Martin Luther University Halle-Wittenberg, Halle, Germany. biochemie@medizin.uni-halle.de
Lennarz
Birgit
B
Glaesser
Dietmar
D
D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology; D002417:Cattle; D005227:Fatty Acids / Q000633:toxicity*; D007908:Lens, Crystalline / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D018613:Microscopy, Confocal; D009924:Organ Culture Techniques
D005227:Fatty Acids