Cytotoxic activities of water-soluble chitosan derivatives with different degree of deacetylation.
Chitosans with different degree of deacetylation (DD) (90% and 50% deacetylated chitosan) were prepared by N-deacetylation followed by grafted onto chitosan to form water-soluble aminoethyl-chitosan (AE-chitosan), and dimetylaminoethyl-chitosan (DMAE-chitosan), diethylaminoethyl-chitosan (DEAE-chitosan). In the present study, cytotoxic activities of the chitosan derivatives were evaluated using three tumor cell lines and two normal cell lines, and structure-activity relationship was suggested. The cytotoxic activity was dependent on their DD and substituted group.
Je
Jae-Young
JY
Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
Cho
Young-Sook
YS
Kim
Se-Kwon
SK
D000107:Acetylation; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000737:chemistry*; D006801:Humans; D012995:Solubility; D014867:Water
D000970:Antineoplastic Agents; D004983:Ethanolamines; D014867:Water; D048271:Chitosan