Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.
1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps.
Lee
Jinho
J
Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, Republic of Korea. jinho@kmu.ac.kr
Kim
Jonghyun
J
Koh
Jong Sung
JS
Chung
Hyun-Ho
HH
Kim
Kyoung-Hee
KH
D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors*; D006827:Hydantoins / Q000494:pharmacology*; D015689:Oncogene Protein p21(ras) / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D006827:Hydantoins; D051231:Farnesyltranstransferase; D015689:Oncogene Protein p21(ras)