Sheep-associated malignant catarrhal fever virus: prospects for vaccine development.
Sheep-associated malignant catarrhal fever is emerging as a significant problem for several ruminant species worldwide. The inability to propagate the causative agent, ovine herpesvirus 2, in vitro has seriously hindered research efforts in the development of effective programs for control of the disease in clinically susceptible hosts. Recent molecular technologic advances have provided powerful tools for investigating this difficult-to-study virus. Identification of the infectious virus source, establishment of experimental animal models and completion of sequencing the genome for ovine herpesvirus 2 have put us in a position to pursue the development of vaccines for control of the disease. In this review, the authors briefly describe the current understanding of ovine herpesvirus 2 and prospectively discuss vaccine development against the virus.
Li
Hong
H
Animal Disease Research Unit, USDA-Agricultural Research Service, 3003 ADBF, WSU, Pullman, WA 99164, USA. hli@vetmed.wsu.edu
Taus
Naomi S
NS
Oaks
J Lindsay
JL
D000818:Animals; D022283:Herpesvirus Vaccines / Q000138:chemical synthesis / Q000627:therapeutic use*; D008304:Malignant Catarrh / Q000235:genetics / Q000517:prevention & control* / Q000821:virology; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics / Q000517:prevention & control* / Q000821:virology; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends*; D014759:Viral Envelope Proteins / Q000235:genetics
D022283:Herpesvirus Vaccines; C438803:Ovine herpesvirus-2 glycoprotein B; D014759:Viral Envelope Proteins