Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans.
Olive oil phenolic compounds are potent antioxidants in vitro, but evidence for antioxidant action in vivo is controversial. We examined the role of the phenolic compounds from olive oil on postprandial oxidative stress and LDL antioxidant content. Oral fat loads of 40 mL of similar olive oils, but with high (366 mg/kg), moderate (164 mg/kg), and low (2.7 mg/kg) phenolic content, were administered to 12 healthy male volunteers in a cross-over study design after a washout period in which a strict antioxidant diet was followed. Tyrosol and hydroxytyrosol, phenolic compounds of olive oil, were dose-dependently absorbed (p<0.001). Total phenolic compounds in LDL increased at postprandial state in a direct relationship with the phenolic compounds content of the olive oil ingested (p<0.05). Plasma concentrations of tyrosol, hydroxytyrosol, and 3-O-methyl-hydroxytyrosol directly correlated with changes in the total phenolic compounds content of the LDL after the high phenolic compounds content olive oil ingestion. A 40 mL dose of olive oil promoted a postprandial oxidative stress, the degree of LDL oxidation being lower as the phenolic content of the olive oil administered increases. In conclusion, olive oil phenolic content seems to modulate the LDL phenolic content and the postprandial oxidative stress promoted by 40 mL olive oil ingestion in humans.
Covas
María-Isabel
MI
Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d'Investigació Mèdica (IMIM), 08003 Barcelona, Spain. mcovas@imim.es
de la Torre
Karina
K
Farré-Albaladejo
Magí
M
Kaikkonen
Jari
J
Fitó
Montserrat
M
López-Sabater
Carmen
C
Pujadas-Bastardes
María A
MA
Joglar
Jesus
J
Weinbrenner
Tanja
T
Lamuela-Raventós
Rosa M
RM
de la Torre
Rafael
R
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004032:Diet; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D000069463:Olive Oil; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D010938:Plant Oils / Q000737:chemistry*; D019518:Postprandial Period
C475000:3-O-methylhydroxytyrosol; D000975:Antioxidants; D008077:Lipoproteins, LDL; D000069463:Olive Oil; D010938:Plant Oils; C005975:3,4-dihydroxyphenylethanol; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol