[Role of morpho-functional changes of blood lymphocytes in pathogenesis of psoriasis and the possibilities for their correction].
It is well known, that the cells of T-lymphoid population including Th2 lymphocytes of the skin, as well as circulating cells has the great importance in the pathogenesis of psoriasis. The goal of given research was to define the role of morpho-functional changes in blood lymphocytes in the pathogenesis of psoriasis and the possibilities for their correction. On the background of our investigation it could be concluded that in the case of the vulgar form of psoriasis in peripheral blood lymphocytes the intensified expression of p-53 preapoptotic protein results from affecting of NO induced damage of DNA molecule, in terms of intensification of oxidative stress in organism, which contributes to the activation of apoptosis of peripheral blood lymphocytes and is presented as one of the reasons which can cause the degradation of lymphocyte-induced apoptosis of keratinocytes. After the course of balneal therapy in "Nunisi" the decrease in expression of p-53 lymphocytes has been observed, big lymphocytes are predominant ones, with indications of synthetic activity of ultrastructure. This effect is conditioned by antioxidative characteristics of waters of "Nunisi" which assists to decreasing of the oxidative stress in patient's organism and recovers redox state of nitrogen oxide; it contributes to the intensification of keratinocytes apoptosis and to the prompt clearance of psoriatic lesion foci in epidermis.
Rukhadze
L Sh
LSh
Gognashvili
L E
LE
Sanikidze
T V
TV
Gudzhabidze
R G
RG
Katsitadze
A G
AG
D000328:Adult; D001452:Balneology / Q000379:methods*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000473:pathology / Q000628:therapy