Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis.
Cytokines are key factors in the cross talk between the immune system and other systems including hepatic, nervous, cardiac and cutaneous systems, leading to an adaptive and integrated response of the organism to stress. They are also involved in the regulation of many processes, including hematopoiesis, the immune response and inflammation. IL-10 is one of the most important anti-inflammatory cytokines. Five cytokines structurally related to IL-10 have been described and presently form this family of cytokines: IL-19, IL-20, IL-22, IL-24 and IL-26. In contrast to IL-10, these cytokines display pro-inflammatory activities in different tissues, including skin. Indeed, some of them induce an inflammatory keratinocyte gene expression profile and an epidermis histology resembling psoriatic lesions. In this review, we discuss recent knowledge about the effects of cytokines of the IL-10 family on keratinocytes and their potential role in psoriasis, a cutaneous inflammatory disease.
Boniface
Katia
K
Laboratoire Cytokines et Inflammation, UPRES-EA 3806, CHU de Poitiers, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France.
Lecron
Jean-Claude
JC
Bernard
François-Xavier
FX
Dagregorio
Guy
G
Guillet
Gérard
G
Nau
François
F
Morel
Franck
F
D000818:Animals; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D016753:Interleukin-10 / Q000502:physiology*; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism*; D005810:Multigene Family / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology
D018836:Inflammation Mediators; D016753:Interleukin-10