title: [Prostate cancer diagnosis using 24 cores extended biopsy].
abstract: OBJECTIVE
  To determine the diagnostic performance of extended prostatic biopsy (PB) in prostate cancer (PC) and variables affecting positivity.
  
  
  METHODS
  Patients (n = 147) underwent 24 cylinder PB at the Arquitecto Marcide Hospital, Ferrol, La Coruña, between December 2002-September 2004. Inclusion criteria were the following: patients aged < or = 70 with one or more negative PB or aged < or = 75 with two or more negative PB. An univariate analysis was carried out using the chi-squared test for the qualitative variables and the t-Student and U Mann-Whitney tests in the case of the quantitative variables, plus a logistical regression analysis in order to identify those variables related to the extended PB positivity.
  
  
  RESULTS
  60 patients (40.82%) were identified as having PC. Significant differences were observed in prostatic volume, free/total PSA ratio in the initial PB, free/total PSA ratio in the extended PB, PSA-density in the extended PB as well as the existence of chronic prostatitis in previous PB. During the multivariate analysis it was found that the PSA-density and the presence of chronic prostatitis in previous PB independently predicted the positivity of the extended PB.
  
  
  CONCLUSIONS
  Extended PB allows for the detection of PC in 40.82% of patients with previous negative PB. The increase in PSA density is associated with a greater probability of PC, whilst the existence of chronic prostatitis in prior PB significantly reduces the probability of PC in the extended PB.
authors.affiliation: Servicios de Urología, Hospital Arquitecto Marcide, Ferrol, La Coruña. arodri68@terra.es
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez Alonso
authors.forename: A
authors.initials: A
authors.lastname: González Blanco
authors.forename: S
authors.initials: S
authors.lastname: Pita Fernandez
authors.forename: G
authors.initials: G
authors.lastname: Suárez Pascual
authors.forename: C
authors.initials: C
authors.lastname: Bonelli Martín
authors.forename: J
authors.initials: J
authors.lastname: Lorenzo Franco
authors.forename: J C
authors.initials: JC
authors.lastname: Alvarez Fernández
authors.forename: M A
authors.initials: MA
authors.lastname: Cuerpo Pérez
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*