[Clinical significance of K-RAS and cytokeratine 20 markers in diagnosis of lymphogenic metastasis of pancreatic cancer].
Aim of the work is to estimate the role of the metastases molecular signs (MMS) in paraaortal lymphatic nodes, revealed using combined molecular-biological method with application of K-RAS markers and cytokeratine 20 (CK20) for the survival prognostication in the pancreatic head cancer patients after performing pancreatoduodenal resection. Actuarial index of general survival of the patients with MMS in paraaortal lymphatic nodes was trustworthy lower than in patients without such a signs. The two-year survival index in patients without MMS was 60%, the survival mediana--32 mo. Any of the patients with MMS did not survive two years, the survival mediana was 13 mo.
Zemskov
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D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D014408:Biomarkers, Tumor / Q000235:genetics*; D018572:Disease-Free Survival; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D053554:Keratin-20; D007633:Keratins / Q000235:genetics*; D008207:Lymphatic Metastasis; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D012150:Polymorphism, Restriction Fragment Length; D020133:Reverse Transcriptase Polymerase Chain Reaction
D014408:Biomarkers, Tumor; C507499:KRT20 protein, human; D053554:Keratin-20; D007633:Keratins