title: In vitro activity of DX-619, a novel des-fluoro(6) quinolone, against a panel of Streptococcus pneumoniae mutants with characterized resistance mechanisms.
abstract: The in vitro activities of DX-619 and four other quinolones were compared against Streptococcus pneumoniae mutants that contained a variety of alterations within the quinolone resistance-determining regions. DX-619 was the most potent quinolone and was least affected by the mutations.
authors.affiliation: Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA. pwickman@creighton.edu
authors.forename: Paul A
authors.initials: PA
authors.lastname: Wickman
authors.forename: Ellen Smith
authors.initials: ES
authors.lastname: Moland
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Black
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Thomson
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011759:Pyrrolidines / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; C505440:DX 619; D011759:Pyrrolidines; D015363:Quinolones