Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide.
Staphylococcus aureus responds with protective strategies against phagocyte-derived reactive oxidants to infect humans. Herein, we report the transcriptome analysis of the cellular response of S. aureus to hydrogen peroxide-induced oxidative stress. The data indicate that the oxidative response includes the induction of genes involved in virulence, DNA repair, and notably, anaerobic metabolism.
Chang
Wook
W
Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park 20742, USA.
Small
David A
DA
Toghrol
Freshteh
F
Bentley
William E
WE
D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D006861:Hydrogen Peroxide; D020411:Oligonucleotide Array Sequence Analysis; D016133:Polymerase Chain Reaction; D012329:RNA, Bacterial / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D013211:Staphylococcus aureus / Q000235:genetics* / Q000502:physiology; D013997:Time Factors; D014158:Transcription, Genetic
D012329:RNA, Bacterial; D012333:RNA, Messenger; D006861:Hydrogen Peroxide