Suitability of calcium phosphate cement for injection laryngoplasty in rabbits.
Calcium phosphate cement (CPC) consists of powder and liquid, which become an injectable paste after mixing, self-hardening and recrystallizing to calcium hydroxylapatite (CaHA) after injection into a living body. In this study, we investigated the suitability of CPC as an injectable material for injection laryngoplasty using rabbits. All rabbits underwent left recurrent laryngeal nerve section and injection laryngoplasty with CPC. At 7 days, scanning electron microscopic findings revealed that complete recrystallization from CPC to CaHA was achieved in the larynx. At 1, 3, and 6 months, injected CPC stayed in the paraglottic space and did not migrate, and the average remaining CPC volume percentage was 91.7%. Focal foreign body reaction to injected CPC was almost the same as that of autologous fat for all time periods observed. These results indicated that CPC appears to be biocompatible, nonabsorbable, nonmigratory, and suitable for injection laryngoplasty.
Ikeda
Asako
A
Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Shiotani
Akihiro
A
Mori
Yuko
Y
Fujimine
Takekatsu
T
Tomifuji
Masayuki
M
Takaoka
Takuji
T
Kameyama
Kaori
K
Ogawa
Kaoru
K
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use*; D003460:Crystallization; D007830:Larynx / Q000601:surgery*; D008855:Microscopy, Electron, Scanning; D013517:Otorhinolaryngologic Surgical Procedures; D011817:Rabbits; D014826:Vocal Cord Paralysis / Q000601:surgery*; D014827:Vocal Cords / Q000601:surgery*
D001672:Biocompatible Materials; D002130:Calcium Phosphates; C020243:calcium phosphate