title: Diabetes insipidus: diagnosis and treatment of a complex disease.
abstract: Diabetes insipidus, characterized by excretion of copious volumes of dilute urine, can be life-threatening if not properly diagnosed and managed. It can be caused by two fundamentally different defects: inadequate or impaired secretion of antidiuretic hormone (ADH) from the posterior pituitary gland (neurogenic or central diabetes insipidus) or impaired or insufficient renal response to ADH (nephrogenic diabetes insipidus). The distinction is essential for effective treatment.
authors.affiliation: North Shore University Hospital, New York University School of Medicine, Manhasset, NY, USA.
authors.forename: Amgad N
authors.initials: AN
authors.lastname: Makaryus
authors.forename: Samy I
authors.initials: SI
authors.lastname: McFarlane
mesh_terms: D003919:Diabetes Insipidus / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D011141:Polyuria / Q000209:etiology