title: Biocompatible properties of surgical mesh using an animal model.
abstract: OBJECTIVE
  To study the biocompatibility of surgical meshes for use in pelvic reconstructive surgery using an animal model.
  
  
  METHODS
  Eight different types of mesh: Atrium, Dexon, Gynemesh, IVS tape, Prolene, SPARC tape, TVT tape and Vypro II, were implanted into the abdominal walls of rats for 3 months' duration. Explanted meshes were assessed, using light microscopy, for parameters of rejection and incorporation.
  
  
  RESULTS
  Type 1 (Atrium, Gynemesh, Prolene, SPARC and TVT) and type 3 (Vypro II, Dexon and IVS) meshes demonstrated different biocompatible properties. Inflammatory cellular response and fibrosis at the interface of mesh and host tissue was most marked with Vypro II and IVS. All type 1 meshes displayed similar cellular responses despite markedly different mesh architecture.
  
  
  CONCLUSIONS
  The inflammatory response and fibrous reaction in the non-absorbable type 3 meshes tested (IVS and Vypro II) was more marked than the type 1 meshes. The increased inflammatory and fibrotic response may be because of the multifilamentous polypropylene components of these meshes. Material and filament composition of mesh is the main factor in determining cellular response.
authors.affiliation: Urogynaecology Unit, Gold Coast Hospital, Southport, Queensland. Australia. hannahkrause@hotmail.com
authors.forename: Hannah G
authors.initials: HG
authors.lastname: Krause
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Galloway
authors.forename: Soo K
authors.initials: SK
authors.lastname: Khoo
authors.forename: Richard
authors.initials: R
authors.lastname: Lourie
authors.forename: Judith T W
authors.initials: JT
authors.lastname: Goh
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007249:Inflammation / Q000209:etiology; D008297:Male; D010388:Pelvis / Q000601:surgery*; D011126:Polypropylenes / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures / Q000379:methods*; D013526:Surgical Mesh
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes