Possibilities of application of non-ionic surfactants belonging to Rofam, Rokopol and Rokanol class in the prescription of dental anti-inflammatory gels.
Belonging to the classes of: Rofams, Rokopols and Rokanols were used to form the gels soap base. The model gels extensibility was investigated by extensometric method, while their viscosity parameters were determined with cone-plate digital rheometer. Regardless of the applied gel vehicle, model prescriptions of dental anti-inflammatory gels with sodium ibuprofen have been worked out. Natural polysaccharides: xanthan gum, tragacanth, guar gum were the vehicles of the formed gels. New non-ionic surfactants the most beneficial results of rheological measurements were obtained for model gels with Rofam R-15. The calculated areas under extensibility curves of preparations with Rofam R-15 are greater than for gels with Rokopol RF55 or Rokanol OC9. Introduction of Rofam R-15 into the prescription is associated with maintenance of low value of yield stress. When this value is exceeded under the effect of slight shear, the gel does not stay long on the surface of its application. High values of theoretical coefficients of sodium ibuprofen diffusion from gels with Rofam R-15, calculated from Einstein-Smoluchowski equation, are the consequence of their low viscosity. The carried out in vitro comparative testing of the kinetics of sodium ibuprofen release from the gel with Rofam R-15 and from gel with sodium estolate of parallel prescription did not demonstrate any basic differences in the size of the areas under the release curves (14,4046 and 13,5308 c.u. for the vehicle with xanthan gum).
Kołodziejska
Justyna
J
Department of Drug Form Technology, Applied Pharmacy Faculty, Medical University, Lodz.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D019540:Area Under Curve; D002626:Chemistry, Pharmaceutical; D003813:Dentistry / Q000379:methods; D020100:Hydrogels / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D014783:Viscosity
D000893:Anti-Inflammatory Agents; D020100:Hydrogels; D013501:Surface-Active Agents