Patterns of evolution of host proteins involved in retroviral pathogenesis.
BACKGROUND
Evolutionary analysis may serve as a useful approach to identify and characterize host defense and viral proteins involved in genetic conflicts. We analyzed patterns of coding sequence evolution of genes with known (TRIM5alpha and APOBEC3G) or suspected (TRIM19/PML) roles in virus restriction, or in viral pathogenesis (PPIA, encoding Cyclophilin A), in the same set of human and non-human primate species.


CONCLUSIONS
This analysis revealed previously unidentified clusters of positively selected sites in APOBEC3G and TRIM5alpha that may delineate new virus-interaction domains. In contrast, our evolutionary analyses suggest that PPIA is not under diversifying selection in primates, consistent with the interaction of Cyclophilin A being limited to the HIV-1M/SIVcpz lineage. The strong sequence conservation of the TRIM19/PML sequences among primates suggests that this gene does not play a role in antiretroviral defense.
Ortiz
Millan
M
Institute of Microbiology, University of Lausanne, Switzerland. millan.Ortiz-serrano@chuv.ch
Bleiber
Gabriela
G
Martinez
Raquel
R
Kaessmann
Henrik
H
Telenti
Amalio
A
D000818:Animals; D019143:Evolution, Molecular; D023281:Genomics; D006790:Host-Parasite Interactions / Q000235:genetics; D011323:Primates / Q000235:genetics / Q000821:virology; D011506:Proteins / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics / Q000472:pathogenicity*; D012641:Selection, Genetic; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000472:pathogenicity
D011506:Proteins