title: Cholestasis induced by parabolan successfully treated with the molecular adsorbent recirculating system.
abstract: We describe a case of a 21-year-old male bodybuilder who overdosed on Parabolan (trenbolone acetate) because of its anabolic activity. The patient, with no previous medical history, experienced pruritus and yellow discoloration of the skin and sclerae. Basic biochemical laboratory examination revealed signs of cholestasis with a serum bilirubin level of up to 65.5 mg/dl. Because supportive medical treatment was ineffective, the patient was treated with the molecular adsorbent recirculating system (MARS). Five MARS cycles lasting from 8 to 12 hours were performed every second day. The procedure was well tolerated by the patient and resulted in a sustained relief of pruritus. At the 2-month follow-up visit the plasma bilirubin level had decreased to 2 mg/dl.
authors.affiliation: Clinic of Internal Medicine and Acute Poisonings, Medical University of Gdańsk, Ul. Debinki 7, 80-211 Gdańsk, Poland.
authors.forename: Jacek Sein
authors.initials: JS
authors.lastname: Anand
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Chodorowski
authors.forename: Adam
authors.initials: A
authors.lastname: Hajduk
authors.forename: Wojciech
authors.initials: W
authors.lastname: Waldman
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000097:blood / Q000139:chemically induced* / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016060:Sorption Detoxification; D013997:Time Factors; D016896:Treatment Outcome; D014204:Trenbolone Acetate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: D045930:Anabolic Agents; D001663:Bilirubin; D014204:Trenbolone Acetate