Screening for tuberculosis in the study of the living renal donor in a developing country.
Given the high prevalence of tuberculosis (Tb) in the Mexican population, a strict program to detect Tb in the potential donor is required. Chest x-ray, excretory urogram, urinalysis with microscopic exam of the sediment, urine cultures for M. tuberculosis, and tuberculin skin test (TST) with PPD-RT23 performed for evaluation of 222 living donors were reviewed. Isoniazid prophylaxis before kidney donation was gathered. Donors and recipients were followed up for a minimum of 2 years. According to the TST result, 36.8% of the donors had latent tuberculosis; however, all other studies were normal or negative in all of them. Use of isoniazid prophylaxis in TST-positive donors made no difference in risk of transmission of tuberculosis to the recipient or development of tuberculosis among the donors. Normal chest x-ray and excretory urogram, along with a negative microscopic examination of the urine, safely exclude tuberculosis transmission to recipients.
Hernández-Hernández
Edy
E
Departamento de Nefrología-Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
Alberú
Josefina
J
González-Michaca
Luis
L
Bobadilla-del Valle
Miriam
M
Quiroz-Mejía
Ruth A
RA
Baizabal-Olarte
Rafael
R
Correa-Rotter
Ricardo
R
Sifuentes-Osornio
José
J
D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D003906:Developing Countries; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008403:Mass Screening; D008800:Mexico; D008875:Middle Aged; D014374:Tuberculin Test; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission*
D000995:Antitubercular Agents; D007538:Isoniazid