title: Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.
abstract: Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.
authors.affiliation: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Kosowska-Shick
authors.forename: Catherine
authors.initials: C
authors.lastname: Clark
authors.forename: Kim
authors.initials: K
authors.lastname: Credito
authors.forename: Pamela
authors.initials: P
authors.lastname: McGhee
authors.forename: Bonifacio
authors.initials: B
authors.lastname: Dewasse
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bogdanovich
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D004224:Diterpenes; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D000090822:Ribosomal Protein L3; D012269:Ribosomal Proteins / Q000737:chemistry / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects*; D013297:Streptococcus pyogenes / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004224:Diterpenes; D011500:Protein Synthesis Inhibitors; D000090822:Ribosomal Protein L3; D012269:Ribosomal Proteins; C508887:retapamulin