Quercitrin: an antileishmanial flavonoid glycoside from Kalanchoe pinnata.
Quercitrin (quercetin 3- O-alpha- L-rhamnopyranoside), one of the constituents of the biologically active aqueous extract obtained from Kalanchoe pinnata, is demonstrated to be a potent antileishmanial compound (IC50 approximately 1 microg/mL) with a low toxicity profile. This is the first time that antileishmanial activity is demonstrated for a flavonoid glycoside.
Muzitano
Michelle F
MF
Núcleo de Pesquisas de Produtos Naturais, , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Cruz
Elaine A
EA
de Almeida
Ana Paula
AP
Da Silva
Silvia A G
SA
Kaiser
Carlos R
CR
Guette
Catherine
C
Rossi-Bergmann
Bartira
B
Costa
Sônia S
SS
D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D031962:Kalanchoe / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000977:Antiparasitic Agents; D010936:Plant Extracts; C012526:quercitrin; D011794:Quercetin