title: Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals.
abstract: We assessed (1) angiogenic factors in patients with stable angina and longstanding (> or =24 months) total occlusion of a single coronary artery and (2) the relation between plasma levels of angiogenic factors and the development of collateral vessels as evaluated by coronary angiography. Plasma concentrations of vascular endothelial growth factor (VEGF(165)), fibroblast growth factor, placenta-derived growth factors (PlGFs), and hepatocyte growth factor were assessed in 96 patients with stable angina and longstanding (> or =24 months) total occlusion of a single coronary artery. According to coronary angiographic results, 18 patients had no visible collaterals (group 0), 21 patients had visible collaterals but no filling of the recipient epicardial vessel (group 1), and 57 patients showed filling (partial or complete) of the recipient epicardial vessel by collaterals (group 2). Plasma VEGF(165) and PlGF concentrations were higher in group 1 than in groups 0 and 2 (VEGF(165) 75 pg/ml, range 24 to 105, vs 23 pg/ml, range 15 to 29, and 19 pg/ml, range 10 to 41, respectively, F = 5.53, p = 0.006; PlGF 35 pg/ml, range 3.5 to 105, vs 1 pg/ml, range 1 to 38, and 1 pg/ml, range 1 to 5, respectively, F = 7.09, p = 0.008). Plasma VEGF(165) and PlGF levels were similar in groups 0 and 2. There was no significant difference in plasma levels of fibroblast and hepatocyte growth factor concentrations across the 3 groups. In conclusion, plasma levels of angiogenic growth factors differ among patients with stable angina pectoris and longstanding total coronary occlusion.
authors.affiliation: Laboratory of Interventional Cardiology and Department of Cardiology, Clinica Mediterranea, Naples, Italy. briguori.carlo@hsr.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Briguori
authors.forename: Ugo
authors.initials: U
authors.lastname: Testa
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
authors.forename: Eleonora
authors.initials: E
authors.lastname: Petrucci
authors.forename: Gerolama
authors.initials: G
authors.lastname: Condorelli
authors.forename: Flavio
authors.initials: F
authors.lastname: Airoldi
authors.forename: Cesare
authors.initials: C
authors.lastname: Peschle
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Condorelli
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000000981:diagnostic imaging; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood; D006133:Growth Substances / Q000097:blood*; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D006133:Growth Substances; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor; D005346:Fibroblast Growth Factors; D017228:Hepatocyte Growth Factor