Effects of fermented soy milk on the liver lipids under oxidative stress.
OBJECTIVE
To investigate the effects of fermented soy milk powder on the antioxidative status and lipid metabolism in the livers of CCl4-injected rats.


METHODS
Forty-five healthy male Sprague-Dawley rats were randomly assigned to five groups according to five different diets: control (AIN-76), AIN-76+high-dose fermented soy milk powder, AIN-76+low-dose fermented soy milk powder, AIN-76+high-dose milk yogurt powder and AIN-76+low-dose milk yogurt powder. The experiment lasted for 8 wk. After 4 wk, all the rats received intraperitoneal administration of CCl(4)(0.2 mL/100 g body weight) every week. Total cholesterol (TC), triglyceride (TG), TBARS, ALP, and antioxidative enzymes in the liver were evaluated.


RESULTS
There was also no significant difference in TBARS and antioxidative enzymes in the liver. TC and TG in the groups fed with fermented soy milk powder were generally lower than those fed with casein powder.


CONCLUSIONS
Consumption of fermented soy milk was positive in lowering total cholesterol and TG accumulation in the liver under CCl(4)-induced oxidative stress.
Lin
Ching-Yi
CY
Graduate Institute of Nutrition and Health Sciences, Taipei Medical University, (110) 250 Wu-Hsing Street, Taipei, Taiwan, China. lin5611@tmu.edu.tw
Tsai
Zheng-Yu
ZY
Cheng
I-Chi
IC
Lin
Shyh-Hsiang
SH
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001628:Beverages; D002251:Carbon Tetrachloride / Q000633:toxicity; D005285:Fermentation; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D011208:Powders; D017392:Thiobarbituric Acid Reactive Substances; D002251:Carbon Tetrachloride; D000469:Alkaline Phosphatase