title: The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology.
abstract: The Exeter Family Study of Childhood Health is a prospective study, set up to test the fetal insulin hypothesis, and to identify genetic polymorphisms that play a role in determining birthweight and early postnatal growth. We recruited 1017 families from a postcode-defined area in central Exeter. Specific inclusion criteria were established to obtain a homogeneous, non-diabetic, UK Caucasian cohort. Detailed anthropometric measurements were taken from both parents at 28 weeks' gestation, and from their children at birth, 12 weeks, 1 year and 2 years of age. Insulin and other biochemical analysis were measured in fasting parental samples and an umbilical cord blood sample taken at delivery. Parental and offspring DNA were extracted to allow molecular genetic analysis of candidate genes implicated in fetal growth. This comprehensive data set is available on a disease-free cohort, and detailed preparatory work has ensured high levels of quality control. The study would welcome collaboration within strict confidentiality rules.
authors.affiliation: Peninsula Medical School, Royal Devon and Exeter NHS Trust, Exeter, UK.
authors.forename: Bridget
authors.initials: B
authors.lastname: Knight
authors.forename: Beverley M
authors.initials: BM
authors.lastname: Shields
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Hattersley
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry / Q000379:methods; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004739:England / Q000453:epidemiology; D005220:Fathers; D005260:Female; D047109:Fetal Development / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006128:Growth / Q000235:genetics*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009035:Mothers; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012107:Research Design
chemical_list: D001786:Blood Glucose; D007328:Insulin