title: Synthesis and anticancer activity of thiosemicarbazones.
abstract: Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 microM.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032, PR China. huyang@mail.hz.zj.cn
authors.forename: Wei-xiao
authors.initials: WX
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Chun-nian
authors.initials: CN
authors.lastname: Xia
authors.forename: Xi
authors.initials: X
authors.lastname: Wen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002246:Carbon Disulfide / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006834:Hydrazines / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006834:Hydrazines; D013882:Thiosemicarbazones; C029424:hydrazine; D002246:Carbon Disulfide