title: The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
abstract: We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer.
authors.affiliation: Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Jiao
authors.forename: Manal M
authors.initials: MM
authors.lastname: Hassan
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Bondy
authors.forename: James L
authors.initials: JL
authors.lastname: Abbruzzese
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Evans
authors.forename: Donghui
authors.initials: D
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics / Q000473:pathology; D000368:Aged; D019943:Amino Acid Substitution; D001216:Asparagine / Q000235:genetics; D001224:Aspartic Acid / Q000235:genetics; D021441:Carcinoma, Pancreatic Ductal / Q000209:etiology / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005973:Glutamine / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008239:Lysine / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D005973:Glutamine; D001224:Aspartic Acid; D001216:Asparagine; D051759:Xeroderma Pigmentosum Group D Protein; D008239:Lysine