Early growth response-1 in cardiovascular pathobiology.
The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amazing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.
Khachigian
Levon M
LM
Centre for Vascular Research, Department of Pathology, The University of New South Wales, The Prince of Wales Hospital, Sydney, Australia. L.Khachigian@unsw.edu.au
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology*; D006332:Cardiomegaly / Q000209:etiology*; D051766:Early Growth Response Protein 1 / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D007511:Ischemia / Q000209:etiology; D018919:Neovascularization, Physiologic; D014184:Transplantation, Homologous; D017539:Tunica Intima / Q000473:pathology
D051766:Early Growth Response Protein 1