title: Adopting orphan drugs--two dozen years of treating rare diseases.
authors.affiliation: Office of Orphan Products Development at the Food and Drug Administration, Rockville, Md, USA.
authors.forename: Marlene E
authors.initials: ME
authors.lastname: Haffner
mesh_terms: D001906:Botulism / Q000188:drug therapy; D002986:Clinical Trials as Topic; D017277:Drug Approval; D004345:Drug Industry; D049673:History, 20th Century; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D009965:Orphan Drug Production / Q000266:history / Q000331:legislation & jurisprudence*; D035583:Rare Diseases / Q000188:drug therapy* / Q000266:history; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; C068584:botulism immune globulin