title: Reaction of the 2'-silyl and 2'-stannyl derivatives of 6-(bromomethyl)dimethylsilyl-1',2'-unsaturated uridine under radical conditions.
abstract: The mode of cyclization (5-exo versus 6-endo) of 2-sila-5-hexen-1-yl radicals generated from 2'-tributylstannyl- and 2'-trimethylsilyl-6-(bromomethyl)dimethylsilyl-1',2'-unsaturated uridines (8 and 9) was investigated. Although the actual structure of the reaction products differ from each other reflecting the ease of elimination of the 2'-substituent, it was found that both substrates prefer the 5-exo-cyclization pathway.
authors.affiliation: School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Ogamino
authors.forename: Hideaki
authors.initials: H
authors.lastname: Mizunuma
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kumamoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haraguchi
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D009947:Organotin Compounds / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D014529:Uridine / Q000031:analogs & derivatives / Q000138:chemical synthesis*
chemical_list: D009947:Organotin Compounds; D012821:Silanes; D014529:Uridine