Microwave-enhanced synthesis of new (-)-steganacin and (-)-steganone aza analogues.
[reaction: see text]. A novel, microwave-enhanced, highly efficient protocol for the synthesis of hitherto unknown (-)-steganacin and (-)-steganone 7-aza analogues containing a 1,2,3-triazole ring has been presented. Microwave irradiation was found to be highly beneficial in promoting the Suzuki reaction and the 1,3-dipolar cycloaddition reaction to generate the highly strained medium-sized ring system of the title molecules.
Beryozkina
Tetyana
T
Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Heverlee, Belgium.
Appukkuttan
Prasad
P
Mont
Nuria
N
Van der Eycken
Erik
E
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis*
D001372:Aza Compounds; D017705:Lignans; D014230:Triazoles; C442624:steganone; C002858:steganacin; D015107:4-Butyrolactone