title: Regulation of V(D)J recombination.
abstract: Adaptive immunity is intimately linked to the expression of antigen-specific immunoglobulin and T cell receptor genes and their recombination assembly from germline V, D and J gene segments. This developmentally regulated process relies on the activity of the Rag1-Rag2 recombinase, on accessibility of target gene segments and on monoallelic gene activation. Recent studies have revealed new mechanisms that, along with recombinase activity and locus accessibility, are likely to contribute to the control of V(D)J recombination, including target-site bias by the recombinase, RNA processing and chromosome positioning.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM), 13288 Marseille Cedex 9, France.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Spicuglia
authors.forename: Don Marc
authors.initials: DM
authors.lastname: Franchini
authors.forename: Pierre
authors.initials: P
authors.lastname: Ferrier
mesh_terms: D000483:Alleles; D000818:Animals; D006801:Humans; D018448:Models, Immunological; D011995:Recombination, Genetic; D045567:VDJ Recombinases / Q000235:genetics* / Q000276:immunology*
chemical_list: D045567:VDJ Recombinases