title: Dopamine selective molecularly imprinted polymers via post-imprinting modification.
abstract: A novel synthetic dopamine receptor bearing bidentate binding sites were prepared by covalent imprinting using a disulfide linkage which is cleaved and oxidized to a non-covalent sulfoxide recognition group. The used templates have dopamine-like structures connected to an allyl moiety via a disulfide and to a 4-vinylphenyl group via a cyclic boronic diester. After the polymerization, the ester bonds were hydrolyzed and the disulfide bond was reduced to remove the template moiety from the polymer matrix, followed by the oxidation to transform the thiol residues into sulfonic acid (post imprinted process). The imprinted polymer adsorbed dopamine selectively in aqueous solution with the two-point interaction, i.e. the formation of cyclic boronic diester and electrostatic interaction with the sulfonic acid residue.
authors.affiliation: Graduate School of Science and Technology, Kobe University, Kobe, 657-8501, Japan. takeuchi@scitec.kobe-u.ac.jp
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Murase
authors.forename: Hideshi
authors.initials: H
authors.lastname: Maki
authors.forename: Takashi
authors.initials: T
authors.lastname: Mukawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Shinmori
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D004298:Dopamine / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013379:Substrate Specificity
chemical_list: D011108:Polymers; D011954:Receptors, Dopamine; D004298:Dopamine