title: Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis.
abstract: Several genetic polymorphisms have been identified in patients with sepsis and severe sepsis, such as the tumor necrosis factor-alpha (TNF-alpha) and TNF-beta genes, the interleukin-1 (IL-1) family, the IL-6, the IL-10, the CD-14, the Toll-like receptors, plasminogen activator inhibitor type 1, and the factor V 1691G-A mutations. In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied. TNF-alpha 308 G/A, PAI-1 4G/4G, and EPCR mutations influence the risk of severe sepsis in children. IL-6 174 G/C, FVL, and Cathepsin G (Ars 125 Ser) did not influence the incidence and mortality of severe sepsis.
authors.affiliation: Department of Pediatric Hematology, Fatih University, Faculty of Medicine, Ankara, Turkey. tansusipahi@hotmail.com
authors.forename: Tansu
authors.initials: T
authors.lastname: Sipahi
authors.forename: Hatice
authors.initials: H
authors.lastname: Pocan
authors.forename: Nejat
authors.initials: N
authors.lastname: Akar
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000235:genetics; D056649:Cathepsin G; D002403:Cathepsins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D000074283:Endothelial Protein C Receptor; D005165:Factor V / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000235:genetics; D017720:Molecular Epidemiology; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics; D018805:Sepsis / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics; D017741:Survivors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; D015850:Interleukin-6; C478370:PROCR protein, human; D017395:Plasminogen Activator Inhibitor 1; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; C095381:factor V Leiden; D005165:Factor V; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G