title: Influence of hyaluronic acid on the time-dependent friction response of articular cartilage under different conditions.
abstract: Therapeutic lubricant injections of hyaluronic acid are a relatively recent treatment for osteoarthritis. Their efficacy, however, in vivo has been subject to much debate. Frictional properties of cartilage-cartilage contacts under both static and dynamic loading conditions have been investigated, using healthy cartilage and cartilage with a physically disrupted surface, with and without the addition of a therapeutic lubricant, hyaluronic acid. Most of the cartilage friction models produced typical time-dependent loading curves, with a rise in static friction with loading time. For the dynamic loading conditions the rise in friction with loading time was dependent on the spatial (and time) variation in the load on the cartilage plate. For sliding distances of 4 mm or greater, when the cartilage plate was unloaded during sliding, the dynamic friction remained low whereas, with shorter sliding distances, the dynamic friction increased with increasing loading time. Static friction was higher than dynamic friction (under the same tribological conditions). The 'damaged' cartilage models produced higher friction than healthy cartilage under equivalent tribological conditions. It was shown that hyaluronic acid was an effective boundary lubricant for articular cartilage under static conditions with both healthy and damaged cartilage surfaces. Hyaluronic acid was less effective under dynamic conditions. However, these dynamic conditions had low friction values with the control lubricant because of the effectiveness of the intrinsic biphasic lubrication of the cartilage. It was only under the tribological conditions in which the cartilage friction was higher and rising with increasing loading time because of depletion of the intrinsic biphasic lubrication, that the role of hyaluronic acid as an effective therapeutic lubricant was demonstrated.
authors.affiliation: School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Bell
authors.forename: E
authors.initials: E
authors.lastname: Ingham
authors.forename: J
authors.initials: J
authors.lastname: Fisher
mesh_terms: D000818:Animals; D002357:Cartilage Diseases / Q000188:drug therapy / Q000503:physiopathology*; D002358:Cartilage, Articular / Q000187:drug effects* / Q000503:physiopathology*; D002417:Cattle; D003198:Computer Simulation; D017276:Friction; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008954:Models, Biological; D013997:Time Factors; D016896:Treatment Outcome; D016474:Weight-Bearing
chemical_list: D006820:Hyaluronic Acid