title: Comment on: "Energy landscape of a small peptide revealed by dihedral angle principal component analysis".
abstract: The dihedral angle principal component analysis method published recently by Mu, Nguyen, and Stock, is shown to produce distortions of the free energy landscape due to the neglect of constraints in the coordinates. It is further shown that these distortions can create artificial minima and energy barriers. The rugged energy landscape that the authors find for a small peptide chain might thus be an artifact of their method.
authors.affiliation: Laboratoire Léon Brillouin (CEA-CNRS), Gif sur Yvette, France. khinsen@cea.fr
authors.forename: Konrad
authors.initials: K
authors.lastname: Hinsen
mesh_terms: D004735:Energy Transfer; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D025341:Principal Component Analysis / Q000379:methods*; D011487:Protein Conformation; D017510:Protein Folding; D013816:Thermodynamics
chemical_list: D010455:Peptides