title: Three-point checklist of dermoscopy: an open internet study.
abstract: BACKGROUND
  In a pilot study, the three-point checklist of dermoscopy has been shown to represent a valid and reproducible tool with high sensitivity for the diagnosis of skin cancer in the hands of a small group of nonexperts.
  
  
  OBJECTIVE
  To re-evaluate these preliminary results in a large number of observers independently from their profession and expertise in dermoscopy.
  
  
  METHODS
  The study was conducted via the internet to provide worldwide access for participants. After a short web-based tutorial, the participants evaluated dermoscopic images of 165 (116 benign and 49 malignant) skin lesions (15 training and 150 test lesions). For each lesion participants scored the presence of the three-point checklist criteria (asymmetry, atypical network and blue-white structures). Kappa values, odds ratios, sensitivity, specificity and likelihood ratios were estimated.
  
  
  RESULTS
  Overall, 150 participants joined the study. The three-point checklist showed good interobserver reproducibility (kappa value: 0.53). Sensitivity for skin cancer (melanoma and basal cell carcinoma) was 91.0% and this value remained basically uninfluenced by the observers' professional profile. Only 20 participants lacking any experience in dermoscopy performed significantly more poorly, but the sensitivity was still remarkably high (86.7%) when considering that they were untrained novices in dermoscopy. The specificity was 71.9% and was significantly influenced by the profession, with dermatologists performing best.
  
  
  CONCLUSIONS
  Our study confirms that the three-point checklist is a feasible, simple, accurate and reproducible skin cancer screening tool.
authors.affiliation: Department of Dermatology, Medical University of Graz, Austria.
authors.forename: I
authors.initials: I
authors.lastname: Zalaudek
authors.forename: G
authors.initials: G
authors.lastname: Argenziano
authors.forename: H P
authors.initials: HP
authors.lastname: Soyer
authors.forename: R
authors.initials: R
authors.lastname: Corona
authors.forename: F
authors.initials: F
authors.lastname: Sera
authors.forename: A
authors.initials: A
authors.lastname: Blum
authors.forename: R P
authors.initials: RP
authors.lastname: Braun
authors.forename: H
authors.initials: H
authors.lastname: Cabo
authors.forename: G
authors.initials: G
authors.lastname: Ferrara
authors.forename: A W
authors.initials: AW
authors.lastname: Kopf
authors.forename: D
authors.initials: D
authors.lastname: Langford
authors.forename: S W
authors.initials: SW
authors.lastname: Menzies
authors.forename: G
authors.initials: G
authors.lastname: Pellacani
authors.forename: K
authors.initials: K
authors.lastname: Peris
authors.forename: S
authors.initials: S
authors.lastname: Seidenari
mesh_terms: D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000473:pathology; D002983:Clinical Competence; D046169:Dermoscopy / Q000379:methods / Q000592:standards*; D003937:Diagnosis, Differential; D006801:Humans; D020407:Internet; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D015588:Observer Variation; D012680:Sensitivity and Specificity; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology