Chaperones and longevity.
That evolution of longevity may depend on alterations in the expression of relatively few regulatory genes has been inferred from the rapid increase in lifespan during evolution of the hominid species (Cutler RG (1979) Mech Ageing Dev 9: 337-354). Also the inherent immortality of the embryonic stem cells implies that replicative senescence (Hayflick L (1997) Biochem Mosc 62: 1180-1190) as possibly aging of species are epigenetic phenomena. Evidence is presented to suggest that the epigenetic changes of the longevity determinants to a significant extend concerns the molecular chaperones. Specific involvement of RNA chaperones in cell immortalization and defective RecQ-DNA chaperones in syndromes of premature aging suggest that DNA/RNA - chaperones probably rank high among the determinants of cellular and species longevity.
Krøll
J
J
Hafnia Unit of Biogerontology, Godthåbsvej 111,3, DK-2000, Frederiksberg, Denmark. krollj@danbbs.dk
D000818:Animals; D016922:Cellular Senescence; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D008136:Longevity; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity
D018832:Molecular Chaperones