Characterization of the expression of the ALK receptor tyrosine kinase in mice.
Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase, was first described as the fusion product causing a subtype of non-Hodgkin's lymphoma. To date Alk has been reported to be mainly expressed in CNS and other parts of the brain. Here we describe an extensive characterization of the mRNA and protein expression of ALK during mouse development. We show that mRNA and ALK protein show overlapping expressing patterns in specific regions of the central and the peripheral nervous systems. Furthermore, ALK is also expressed in the eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach and midgut but not the hindgut. Expression of ALK is also found in testis and ovary.
Vernersson
Emma
E
Department of Medical Biosciences/Pathology, Building 6M, 2nd Floor, Umeå University, S-901 87 Umeå, Sweden.
Khoo
Nelson K S
NK
Henriksson
Maria L
ML
Roos
Göran
G
Palmer
Ruth H
RH
Hallberg
Bengt
B
D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D000918:Antibody Specificity; D001483:Base Sequence; D017931:DNA Primers; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases
D017931:DNA Primers; D012333:RNA, Messenger; C000626174:Alk protein, mouse; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases