title: Acute antibody-mediated rejection of cardiac transplants.
abstract: Under the direction of the International Society for Heart and Lung Transplantation, a multidisciplinary review of the cardiac biopsy grading system was undertaken in 2004, with task forces examining the areas of histopathology of rejection, clinical issues, and research. An important new area addressed by the Immunopathology Task Force sub-committee was the clinical and diagnostic criteria for antibody-mediated rejection. This article is a companion paper to the revised working formulation for the standardization of nomenclature in the diagnosis of heart rejection and reviews the published literature documenting the serologic and morphologic evidence that antibody-mediated rejection is clinically significant and associated with graft loss, accelerated transplant-associated coronary artery disease, and death. This article also provides a more in-depth analysis of antibody-mediated rejection developed by the Immunopathology Task Force for revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 1335, Los Angeles, CA 90095, USA.
authors.forename: Elaine F
authors.initials: EF
authors.lastname: Reed
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Demetris
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hammond
authors.forename: Silviu
authors.initials: S
authors.lastname: Itescu
authors.forename: Jon A
authors.initials: JA
authors.lastname: Kobashigawa
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Reinsmoen
authors.forename: E Rene
authors.initials: ER
authors.lastname: Rodriguez
authors.forename: Marlene
authors.initials: M
authors.lastname: Rose
authors.forename: Susan
authors.initials: S
authors.lastname: Stewart
authors.forename: Nicole
authors.initials: N
authors.lastname: Suciu-Foca
authors.forename: Adriana
authors.initials: A
authors.lastname: Zeevi
authors.forename: Michael C
authors.initials: MC
authors.lastname: Fishbein
mesh_terms: D000906:Antibodies / Q000276:immunology* / Q000502:physiology*; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000917:Antibody Formation; D001706:Biopsy; D003324:Coronary Artery Disease / Q000209:etiology / Q000276:immunology; D006084:Graft Rejection / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology; D006680:HLA Antigens / Q000276:immunology; D016027:Heart Transplantation / Q000009:adverse effects / Q000276:immunology* / Q000502:physiology; D006801:Humans; D015994:Incidence; D009626:Terminology as Topic
chemical_list: D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D006680:HLA Antigens