title: Linkage mapping of a complex trait in the New York population of the GAW14 simulated dataset: a multivariate phenotype approach.
abstract: Multivariate phenotypes underlie complex traits. Thus, instead of using the end-point trait, it may be statistically more powerful to use a multivariate phenotype correlated to the end-point trait for detecting linkage. In this study, we develop a reverse regression method to analyze linkage of Kofendrerd Personality Disorder affection status in the New York population of the Genetic Analysis Workshop 14 (GAW14) simulated dataset. When we used the multivariate phenotype, we obtained significant evidence of linkage near four of the six putative loci in at least 25% of the replicates. On the other hand, the linkage analysis based on Kofendrerd Personality Disorder status as a phenotype produced significant findings only near two of the loci and in a smaller proportion of replicates.
authors.affiliation: Human Genetics Unit, Indian Statistical Institiute, 203 B,T, Road, Kolkata 700 108, India. saurabh@isical.ac.in
authors.forename: Saurabh
authors.initials: S
authors.lastname: Ghosh
authors.forename: Samsiddhi
authors.initials: S
authors.lastname: Bhattacharjee
authors.forename: Gourab
authors.initials: G
authors.lastname: Basu
authors.forename: Sandip
authors.initials: S
authors.lastname: Pal
authors.forename: Partha P
authors.initials: PP
authors.lastname: Majumder
mesh_terms: D002874:Chromosome Mapping; D003198:Computer Simulation; D003226:Congresses as Topic; D030541:Databases, Genetic; D008040:Genetic Linkage; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D015999:Multivariate Analysis; D009518:New York; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D019655:Quantitative Trait, Heritable