Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures.
Benzodiazepine based heterocycles can be prepared efficiently on solid-support by employing different approaches. In this review, an effort has been made to highlight academic and industrial examples of combinatorial synthesis for this type of heterocycles published in the last decade. Therefore, it describes synthetic strategies for the generation of benzodiazepine privileged structures employing the corresponding resin-bound substrates. Further, the most relevant biological properties of these heterocycles have also been incorporated.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
Reddy
K Laxma
KL
Devaiah
V
V
Shankaraiah
N
N
Reddy
D Rajasekhar
DR
D000470:Alkaloids / Q000138:chemical synthesis; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D001570:Benzodiazepinones / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis
D000470:Alkaloids; D001570:Benzodiazepinones; D011758:Pyrroles; D014230:Triazoles; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; C003256:propizepine; D001569:Benzodiazepines; C020168:triazulenone; C468549:Bz-423