Dopamine receptors do not influence beta2-sympathomimetic-mediated inhibition of gastric acid secretion in the dog.
The effect of dopamine blockade by haloperidol and metoclopramide on beta2-adrenergic-induced changes of acid secretion and pulse rate was studied in conscious gastric fistula dogs. Neither haloperidol (0.15 mg/kg and 0.60 mg/kg) nor metoclopramide (0.25 mg/kg and 1.0 mg/kg), given intravenously, had a significant influence on beta2-adrenergic-induced inhibition of gastric acid secretion or tachycardia. Dopamine blockade had no influence on pentagastrin-stimulated gastric acid secretion, but it increased pulse rate. It is concluded that dopamine receptors are not involved in the inhibiton of acid output or tachycardia induced by beta2-sympathomimetics, and dopamine is probably not a neurotransmitter for these effects.
Gottrup
F
F
University Dept. of Surgical Gastroenterology, Aarhus Amtssygehus, Aarhus, Denmark.
Hovendal
C P
CP
Andersen
D
D
D058666:Adrenergic beta-2 Receptor Agonists; D000818:Animals; D004285:Dogs; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects*; D013566:Sympathomimetics / Q000494:pharmacology*
D058666:Adrenergic beta-2 Receptor Agonists; D018492:Dopamine Antagonists; D004983:Ethanolamines; D013566:Sympathomimetics; D010418:Pentagastrin; D006220:Haloperidol; D008787:Metoclopramide; C100251:salmefamol