title: Investigation of the effect of hyperbaric oxygen on experimental cyclosporine nephrotoxicity.
abstract: Hyperbaric oxygen interacts with drugs which patients use concurrently with hyperbaric oxygen treatment, which may cause in potentiation or inhibition of both therapeutic and toxic effects. We examined the effect of hyperbaric oxygen therapy on experimental cyclosporine A nephrotoxicity. The study comprised four groups of rats: a control group, a cyclosporine A group (25 mg/kg/day intraperitoneally for four days), a hyperbaric oxygen group (60 min. every day for four days at 2.5 atmospheric pressure), and a cyclosporine A+hyperbaric oxygen group (CsA 25 mg/kg/day intraperitoneally for four days+hyperbaric oxygen for 60 min. every day for four days at 2.5 atmospheric pressure). Hyperbaric oxygen did not alter biochemical parameters. Cyclosporine A increased serum urea and serum creatinine levels and decreased creatinine clearance. In the cyclosporine A+hyperbaric oxygen group serum urea level increased more than in the cyclosporine A group. Cyclosporine A increased tubular epithelial cell apoptosis and necrosis score values. The numbers of apoptotic cells in proximal tubule epithelial cells in the cyclosporine A+hyperbaric oxygen group were significantly higher than those of the cyclosporine A group. We recommend that renal functions of the patients receiving cyclosporine A should be monitored during hyperbaric oxygen therapy.
authors.affiliation: Department of Nephrology,Gulhane Military Medical Academy, Haydarpasa Training Hospital 34668 Kadikoy-Istanbul, Turkey.
authors.forename: Enes Murat
authors.initials: EM
authors.lastname: Atasoyu
authors.forename: Senol
authors.initials: S
authors.lastname: Yildiz
authors.forename: Maide
authors.initials: M
authors.lastname: Cimsit
authors.forename: Hakan
authors.initials: H
authors.lastname: Cermik
authors.forename: Tauland
authors.initials: T
authors.lastname: Qyrdedi
authors.forename: T Rifki
authors.initials: TR
authors.lastname: Evrenkaya
authors.forename: Samil
authors.initials: S
authors.lastname: Aktas
authors.forename: Gunalp
authors.initials: G
authors.lastname: Uzun
authors.forename: Oguz
authors.initials: O
authors.lastname: Bilgi
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gultepe
mesh_terms: D000818:Animals; D017209:Apoptosis; D016572:Cyclosporine / Q000633:toxicity*; D006931:Hyperbaric Oxygenation; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016572:Cyclosporine