title: siRecords: an extensive database of mammalian siRNAs with efficacy ratings.
abstract: Short interfering RNAs (siRNAs) have been gaining popularity as the gene knock-down tool of choice by many researchers because of the clean nature of their workings as well as the technical simplicity and cost efficiency in their applications. We have constructed siRecords, a database of siRNAs experimentally tested by researchers with consistent efficacy ratings. This database will help siRNA researchers develop more reliable siRNA design rules; in the mean time, siRecords will benefit experimental researchers directly by providing them with information about the siRNAs that have been experimentally tested against the genes of their interest. Currently, more than 4100 carefully annotated siRNA sequences obtained from more than 1200 published siRNA studies are hosted in siRecords. This database will continue to expand as more experimentally tested siRNAs are published.
  
  
  BACKGROUND
  The siRecords database can be accessed at http://siRecords.umn.edu/siRecords/
authors.affiliation: Department of Neuroscience, University of Minnesota Minneapolis, MN 55455, USA.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Ren
authors.forename: Wuming
authors.initials: W
authors.lastname: Gong
authors.forename: Qiqi
authors.initials: Q
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Zheng
authors.forename: Dong
authors.initials: D
authors.lastname: Lin
authors.forename: Yejun
authors.initials: Y
authors.lastname: Wang
authors.forename: Tongbin
authors.initials: T
authors.lastname: Li
mesh_terms: D000043:Abstracting and Indexing / Q000379:methods; D030541:Databases, Genetic; D020868:Gene Silencing; D018390:Gene Targeting / Q000379:methods*; D020407:Internet; D009323:Natural Language Processing; D039781:PubMed; D034741:RNA, Small Interfering / Q000145:classification* / Q000235:genetics*
chemical_list: D034741:RNA, Small Interfering