Isoflavonoids with antiestrogenic activity from Millettia pachycarpa.
Three new isoflavonoids, named millewanins G (1) and H (2) and furowanin B (3), were isolated from the leaves of Millettia pachycarpa. Their structures were elucidated on the basis of spectroscopic analyses. The antiestrogenic activity in the yeast two-hybrid assay of these isoflavonoids was examined and shown to be comparable with that of 4-hydroxytamoxifen.
Ito
Chihiro
C
Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
Itoigawa
Masataka
M
Kumagaya
Minako
M
Okamoto
Yoshinori
Y
Ueda
Koji
K
Nishihara
Tsutomu
T
Kojima
Nakao
N
Furukawa
Hiroshi
H
D020847:Estrogen Receptor Modulators / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007564:Japan; D033641:Millettia / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D015003:Yeasts / Q000187:drug effects; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors
D020847:Estrogen Receptor Modulators; D007529:Isoflavones; C508678:furowanin B; C508676:millewanin G; C508677:millewanin H; D001616:beta-Galactosidase