title: A critical role for dorsal progenitors in cortical myelination.
abstract: Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.
authors.affiliation: Center for Developmental Biology, Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Yue
authors.forename: Kendy
authors.initials: K
authors.lastname: Xian
authors.forename: Edward
authors.initials: E
authors.lastname: Hurlock
authors.forename: Mei
authors.initials: M
authors.lastname: Xin
authors.forename: Steven G
authors.initials: SG
authors.lastname: Kernie
authors.forename: Luis F
authors.initials: LF
authors.lastname: Parada
authors.forename: Q Richard
authors.initials: QR
authors.lastname: Lu
mesh_terms: D000483:Alleles; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation; D019070:Cell Lineage; D002465:Cell Movement; D003337:Corpus Callosum / Q000196:embryology / Q000254:growth & development / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental; D019426:Integrases / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009024:Morphogenesis; D039902:Multipotent Stem Cells / Q000166:cytology*; D009186:Myelin Sheath / Q000502:physiology* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D000076104:Oligodendrocyte Transcription Factor 2; D009836:Oligodendroglia / Q000502:physiology*; D011995:Recombination, Genetic; D013687:Telencephalon / Q000166:cytology* / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D014764:Viral Proteins / Q000502:physiology
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D019426:Integrases; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; D014764:Viral Proteins; C512773:Olig2 protein, mouse; C045073:Cre recombinase