title: [Early transformation from follicular lymphoma to Burkitt lymphoma].
abstract: We report a rare case of follicular lymphoma which rapidly showed transformation to the Burkitt type of lymphoma after a treatment consisting of chemotherapy and irradiation. A 51-year-old male visited our hospital in August 2000 because of bilateral neck lymphadenopathy. He was diagnosed as having follicular lymphoma (grade 2) (clinical stage IIIA) with complex karyotypic abnormalities involving t(14 ; 18)(q32 ; q21) and CD20 expression. Initially he was followed as an outpatient without chemotherapy. Six months later, he was admitted because of hydronephrosis due to an intrapelvic tumor. He underwent chemotherapy with 4 courses of CHOP regimen following irradiation therapy and a partial response was obtained. Four months after initiation of the treatment, his disease recurred with numb chin syndrome. Bone marrow aspiration revealed bone marrow involvement by lymphoma cells which had a Burkitt-like appearance. A cytogenetic study using bone marrow blood showed complex abnormalities involving t(8 ; 22)(q24 ; q11) in addition to t(14 ; 18). In spite of salvage chemotherapy, the patient died in September 2001.
authors.affiliation: Second Department of Internal Medicine, Gifu Municipal Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Shimomura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tsurumi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamada
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tomita
authors.forename: Hisataka
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016879:Salvage Therapy; D014178:Translocation, Genetic / Q000235:genetics