Solid-phase synthesis of biologically interesting compounds containing hydroxamic acid moiety.
Chemical strategies developed for the solid-phase synthesis of hydroxamates are divided into four groups: (i) the traditional synthesis of hydroxamates via cleavage of resin-bound esters by hydroxylamine and its derivatives, (ii) introduction of hydroxamic acid moiety on the resin-bound precursor, (iii) transformation of polymer-supported hydroxylamine, attached to a solid supported linker either by oxygen (O-linking strategy) or by nitrogen (N-linking strategy), and (iv) synthesis of N-alkyl hydroxamates. The scope and limitation of individual approaches are discussed.
Krchnák
Viktor
V
Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, IN 46556, USA. vkrchnak@nd.edu
D001190:Arylsulfonates / Q000138:chemical synthesis; D002264:Carboxylic Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003676:Deferoxamine / Q000138:chemical synthesis; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D019811:Hydroxylamine / Q000737:chemistry; D015394:Molecular Structure; D017262:Siderophores / Q000138:chemical synthesis; D047090:beta-Lactams / Q000138:chemical synthesis
D001190:Arylsulfonates; D002264:Carboxylic Acids; D006877:Hydroxamic Acids; D017262:Siderophores; D047090:beta-Lactams; D019811:Hydroxylamine; D003676:Deferoxamine