[Molecular mechanisms involved in adrenocortical tumorigenesis].
The adrenocortical tumorigenesis is a complex process, which involves multiple genetic changes. A better knowledge on the mechanisms involved in tumor development would enable an early identification of malignant disease and also lead to the development of new treatment strategies. Although in the recent years a large amount of data was produced, the exact mechanisms that lead to adrenocortical tumor development remains poorly understood. Most of the studies produced were based on the candidate-gene strategy, which has its own limitations. A genome-wide approach, such as microarrays, will surely shed some light into the mechanisms responsible for adrenocortical tumorigenesis. In this review, we summarize the most recent data available on this complex process.
Lerario
Antonio Marcondes
AM
Laboratório de Hormônios e Genética Molecular, LIM 42, HCFMUSP, São Paulo, SP. amlerario@uol.com.br
Mendonça
Berenice B de
BB
Lin
Chin Jia
CJ
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000235:genetics*; D002869:Chromosome Aberrations; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods
D005819:Genetic Markers