title: [Successful treatment with CHOP therapy for progressive of primary macroglobulinemia without further increase of serum IgM].
abstract: A 61-year-old man with primary macroglobulinemia (PMG) had been followed without any treatment as he had no apparent manifestations. After 1 year and 3 months, he was admitted to our hospital with a fever. No signs or symptoms of infection and no progressive increase of serum IgM levels was observed. Non-Hodgkin's lymphoma was not additionally found. Fever without infection, elevated serum LDH level and further enlargement of the spleen compelled us to diagnose his condition as deterioration of the PMG. An immediate fall in his temperature and serum IgM levels was observed after CHOP therapy. Effective therapy must be discussed in the deterioration of this type of disease.
authors.affiliation: Department of Internal Medicine, Division of Hematology, Saitama Medical School.
authors.forename: Naoki
authors.initials: N
authors.lastname: Wakimoto
authors.forename: Motohiro
authors.initials: M
authors.lastname: Misumi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Maeda
authors.forename: Tsuneyuki
authors.initials: T
authors.lastname: Shimada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Wakao
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Sato
authors.forename: Naoki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sugahara
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yoshida
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Yagasaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kawai
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Itsuro
authors.initials: I
authors.lastname: Jinnai
authors.forename: Masami
authors.initials: M
authors.lastname: Bessho
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D015415:Biomarkers; D007075:Immunoglobulin M; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone