title: Epidemiology of pemphigus in south-western Iran: a 10-year retrospective study (1991-2000).
abstract: BACKGROUND
  Pemphigus is a disease demonstrating an uneven geographic distribution. This is the first epidemiologic study of pemphigus in Iran.
  
  
  METHODS
  Data were collected from the files of all newly registered patients with pemphigus at the sole dermatologic referral center for south-western Iran located in the city of Shiraz, during the period 1991-2000. The data were analyzed with regard to age, sex, subtypes of pemphigus, clinical presentation, and season of onset.
  
  
  RESULTS
  The results showed that the mean incidence of the disease for the overall population in Shiraz was 0.67/10(5)/year. The male to female ratio was 1 : 1.33. The mean age at onset of the disease was 38 years (range, 12-93 years). The disease was most common in the third to fifth decades (62.1% of the overall patients). Pemphigus vulgaris was the most commonly encountered type, followed by pemphigus foliaceus (87.7% and 9%, respectively). The first manifestations of the illness most often occurred during winter (30.8% of the patients).
  
  
  CONCLUSIONS
  The results reveal a high incidence of pemphigus vulgaris in south-western Iran compared with that encountered in other countries. Our patients also had a relatively young age at onset and a female predominance.
authors.affiliation: Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Salmanpour
authors.forename: H
authors.initials: H
authors.lastname: Shahkar
authors.forename: M R
authors.initials: MR
authors.lastname: Namazi
authors.forename: M R
authors.initials: MR
authors.lastname: Rahman-Shenas
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D003622:Dapsone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000188:drug therapy / Q000453:epidemiology*; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies; D012621:Seasons; D017678:Sex Distribution
chemical_list: D000890:Anti-Infective Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003622:Dapsone; D011239:Prednisolone; D001379:Azathioprine