Chemical constituents of the roots of Piper sarmentosum.
Sixteen compounds were isolated from the fresh roots of Piper sarmentosum. Seven of these have been previously isolated from the fruits and leaves of this plant: the aromatic alkene (1), 1-allyl-2-methoxy-4,5-methylenedioxybenzene (4), beta-sitosterol, pyrrole amide (6), sarmentine (10), sarmentosine (13) and pellitorine (14). (+)-Sesamin (2), horsfieldin (3), two pyrrolidine amides 11 and 12, guineensine (15) and brachystamide B (16) are new for P. sarmentosum. Sarmentamide A, B, and C (7-9) are new natural products. Compounds 1--4 and 6--16 were tested for antiplasmodial, antimycobacterial and antifungal activities.
Tuntiwachwuttikul
Pittaya
P
Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand. pittayat@su.ac.th
Phansa
Photchana
P
Pootaeng-On
Yupa
Y
Taylor
Walter Charles
WC
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D011759:Pyrrolidines; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000962:Antimalarials; D000995:Antitubercular Agents; D010936:Plant Extracts; D011759:Pyrrolidines; D011760:Pyrrolidinones; C509309:sarmentamide A; C509310:sarmentamide B; C509311:sarmentamide C