[Sox family regulate chondrogenesis].
Recent studies reveal that Sox family play crucial roles in cell lineage determination and cell differentiation during embryogenesis. In vitro analyses of type II collagen gene strongly suggested that Sox5, 6, and 9 are involved in cartilage-specific expression of type II collagen gene. Indeed, mouse genetics approaches clearly indicate that these Sox family transcription factors are essential for chondrogenesis.
Akiyama
Haruhiko
H
Department of Orthopaedics, Kyoto University.
D000818:Animals; D020219:Chondrogenesis / Q000235:genetics*; D024043:Collagen Type II / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D006609:High Mobility Group Proteins / Q000235:genetics*; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics*; D055758:SOX9 Transcription Factor; D055755:SOXD Transcription Factors; D014157:Transcription Factors / Q000235:genetics*
D024043:Collagen Type II; D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins; D055758:SOX9 Transcription Factor; D055755:SOXD Transcription Factors; C089186:Sox5 protein, mouse; C527933:Sox9 protein, mouse; D014157:Transcription Factors