title: Inhibition of fatty acid beta-oxidation attenuates the reinforcing effects and palatability to fat.
abstract: OBJECTIVE
  We investigated the effects of the energy signal on the reinforcing effects and palatability to fat in mice.
  
  
  METHODS
  To examine the effects of postingestive energy signal, mice were injected with 400 micromol/kg body mass of mercaptoacetate, a beta-oxidation blocker or with saline (control group). Reinforcing effects and palatability response were examined with the conditioned place preference and one-bottle tests, respectively.
  
  
  RESULTS
  In conditioned place preference tests, the mercaptoacetate group exhibited reinforcing effects when offered a 40% sucrose solution, which is not metabolized by the beta-oxidation pathway, but not when offered 100% corn oil. The control group exhibited reinforcing effects when offered the sucrose solution and when offered corn oil. In one-bottle tests, the control group exhibited palatability to corn oil, but the mercaptoacetate group did not. Consumption of sucrose solution was identical for both groups.
  
  
  CONCLUSIONS
  These results suggest that postingestive energy signal influences the reinforcing effects and palatability of fat.
authors.affiliation: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Suzuki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamane
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological; D003314:Corn Oil / Q000008:administration & dosage / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004063:Digestion; D004435:Eating / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D005518:Food Preferences / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction; D019518:Postprandial Period; D011897:Random Allocation; D013395:Sucrose / Q000008:administration & dosage / Q000378:metabolism; D013649:Taste / Q000502:physiology*; D013864:Thioglycolates / Q000494:pharmacology
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D013864:Thioglycolates; D013395:Sucrose; C017487:2-mercaptoacetate; D003314:Corn Oil