Tumor suppressors: control of signaling by endocytosis.
Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.
Giebel
Bernd
B
Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, Geb. 14.80, 40225 Düsseldorf, Germany.
Wodarz
Andreas
A
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D016764:Cell Polarity / Q000502:physiology*; D049109:Cell Proliferation; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D004705:Endocytosis / Q000235:genetics / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D004847:Epithelial Cells / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
D002352:Carrier Proteins; D029721:Drosophila Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; C511665:Vps25 protein, Drosophila; C064360:crb protein, Drosophila