title: Prevalence of HIV status and CD4 counts in a surgical cohort: their relationship to clinical outcome.
abstract: BACKGROUND
  HIV positivity alone as a predictor of surgical outcome has not been extensively studied in regions of high prevalence. The aim was to determine the prevalence of HIV infection in surgical patients, and compare differences in their clinical course based on their serological status and CD4 counts.
  
  
  METHODS
  A prospective cohort of 350 patients, enrolled over 6 weeks, were studied. HIV status was determined in all patients. HIV-positive patients had CD4 counts. Clinical details were collated with HIV data after completion of enrollment.
  
  
  RESULTS
  Of the 350 patients, all but 6 were black South Africans. The median age was 31 years (range, 18-82 years). There were 143 trauma and 207 non-trauma patients. The male:female ratio was 1.4:1. The overall HIV seropositivity rate was 39% (females, 46%; males, 36%). Overall, 228 patients had surgical intervention and 96 patients had drainage of sepsis. The hospital stay (HIV negative, 11.9 +/- 15.9 days; HIV positive, 11.0 +/- 15 days) and mortality (HIV positive, 3.6%; HIV negative, 3.7%) did not differ by major diagnostic category. For HIV-positive patients, the male:female ratio was 1.2:1. There were 54 trauma and 83 non-trauma patients. An operation for the drainage of a septic focus was commoner in the HIV-positive admissions. Thirty-two (24%) patients had CD4 counts less than 200 cells/mm3, (i.e. AIDS). The hospital mortality, hospital stay and severity of sepsis were not related to CD4 counts.
  
  
  CONCLUSIONS
  HIV status does not influence the outcome of general surgical admissions and should not influence surgical management decisions. In HIV-positive surgical patients, CD4 counts have no relation to in-hospital outcome in a heterogeneous group of surgical patients.
authors.affiliation: Department of Surgery, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.
authors.forename: S R
authors.initials: SR
authors.lastname: Cacala
authors.forename: E
authors.initials: E
authors.lastname: Mafana
authors.forename: S R
authors.initials: SR
authors.lastname: Thomson
authors.forename: A
authors.initials: A
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018791:CD4 Lymphocyte Count; D004322:Drainage; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018805:Sepsis / Q000601:surgery; D017678:Sex Distribution; D013514:Surgical Procedures, Operative; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications / Q000601:surgery