title: Glial fibrillary acidic protein expression after electroconvulsive shocks in rat brain.
abstract: OBJECTIVE
  The aim of the present study was to assess the effect of electroconvulsive shock (ECS) in glial fibrillary acidic protein (GFAP) expression in rat brain.
  
  
  METHODS
  Rats were given either a single (acute) or a series of eight (chronic) ECS. Brain regions were isolated and levels of glial fibrillary acidic protein (GFAP) in the brain tissue (cortex, hippocampus, and cerebellum) were assessed using an enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  We showed that GFAP expression is reduced in the hippocampus within 48 h and 7 days after acute ECS. GFAP levels are increased in the cerebellum immediately after acute and chronic ECS. No changes were observed in the cortex.
  
  
  CONCLUSIONS
  Our findings showed a differential effect of acute and chronic ECS in the astroglial response in the brain of rats.
authors.affiliation: Laboratório de Psiquiatria Experimental, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: Keila M
authors.initials: KM
authors.lastname: Ceresér
authors.forename: Benício N
authors.initials: BN
authors.lastname: Frey
authors.forename: Fernanda B
authors.initials: FB
authors.lastname: Bernardes
authors.forename: Sabrina C
authors.initials: SC
authors.lastname: Costa
authors.forename: Ana C
authors.initials: AC
authors.lastname: Andreazza
authors.forename: Gustavo
authors.initials: G
authors.lastname: Feier
authors.forename: Daniela
authors.initials: D
authors.lastname: Souza
authors.forename: Francine
authors.initials: F
authors.lastname: Tramontina
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Gonçalves
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapczinski
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D004597:Electroshock; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D015870:Gene Expression / Q000528:radiation effects*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D005904:Glial Fibrillary Acidic Protein