title: Ribose-modified mizoribine analogues: synthesis and biological evaluation.
abstract: Synthesis, conformational analysis and antitumor evaluation of 2'- and 3'-C-methyl analogues of mizoribine (bredinine, 4-carbamoyl-1-beta-D-ribofuranosylimidazole-5-olate) are reported.
authors.affiliation: Dipartimento di Scienze Chimiche, Universitá di Camerino, Italy.
authors.forename: Palmarisa
authors.initials: P
authors.lastname: Franchetti
authors.forename: Michela
authors.initials: M
authors.lastname: Pasqualini
authors.forename: Loredana
authors.initials: L
authors.lastname: Cappellacci
authors.forename: Riccardo
authors.initials: R
authors.lastname: Petrelli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Vita
authors.forename: Mario
authors.initials: M
authors.lastname: Grifantini
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D020014:K562 Cells; D015394:Molecular Structure; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D004791:Enzyme Inhibitors; D012263:Ribonucleosides; C010052:mizoribine; D007168:IMP Dehydrogenase