[Proton magnetic resonance spectroscopy in the evaluation of cognitive disturbances].
Magnetic resonance spectroscopy can detect metabolic changes in the brain, including changes in N-acetyl aspartate, a metabolite generally believed to be a marker of neuronal integrity. The correlations between metabolic changes and cognitive status in normal subjects and in a range of neurological and psychiatric disorders are reviewed. Magnetic resonance spectroscopy seems to be a way to monitor the efficacy of existing and new treatments to prevent the development of cognitive deficits in a number of diseases.
Mathiesen
Henrik Kahr
HK
H:S Hvidovre Hospital, MR-afdelingen, Hvidovre. henrikm@drcmr.dk
Nielsen
Annette Skraep
AS
Nielsen
Kirsten
K
Hanson
Lars Grüner
LG
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
D015415:Biomarkers; D001224:Aspartic Acid; C000179:N-acetylaspartate