Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease.
Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease.


OBJECTIVE
To test the hypothesis that regular exercise alters low-density lipoprotein (LDL) oxidability in patients with coronary artery disease.


METHODS
Longitudinal study.


METHODS
General hospital and community.


METHODS
Thirteen patients.


METHODS
Training program comprising running bouts twice weekly over 2 months.


METHODS
Plasma lipid profile, oxidized LDL, and rate (Ox(rate)) and amount (Ox(amount)) of LDL reaction products were measured at baseline and after 2 months of training. Brachial artery endothelium-dependent and -independent vasodilation was assessed by use of ultrasound.


RESULTS
Lipid profile and oxidized LDL remained unchanged, but mean Ox(rate) and Ox(amount) +/- standard deviation were reduced from 2.5+/-1.5nmol.mgLDL(-1).min(-1) and 120.3+/-75.3nmol/mgLDL at baseline to 0.4+/-0.2nmol.mgLDL(-1).min(-1) and 21.3+/-11.4nmol/mgLDL after training (P<.05), respectively. Brachial artery vasodilation was suggested to be improved, but statistical significance was not reached in the small cohort under study.


CONCLUSIONS
Aerobic training enhances the resistance of LDL to oxidation in patients with coronary artery disease, which may play a role in the favorable effects of exercise.
Ziegler
Sophie
S
Department of Angiology, Medical University of Vienna, Austria. sophie.ziegler@meduniwien.ac.at
Schaller
Georg
G
Mittermayer
Friedrich
F
Pleiner
Johannes
J
Mihaly
Judith
J
Niessner
Alexander
A
Richter
Bernhard
B
Steiner-Boeker
Sabine
S
Penak
Martina
M
Strasser
Barbara
B
Wolzt
Michael
M
D001916:Brachial Artery / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000378:metabolism / Q000503:physiopathology / Q000534:rehabilitation*; D015444:Exercise; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012420:Running; D014664:Vasodilation
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein