Effect of polysaccharide extracted from Glaciecola polaris on the protection of mouse macrophages from oxidative injury.
The effect of the protein-bound polysaccharide extracted from Glaciecola polaris (PSG) was investigated in vitro in the protection of oxidatively-injured mouse macrophages stressed by tert-butyl hydroperoxide (tbOOH) or by oxidatively modified low-density lipoprotein (Ox-LDL). The results showed that PSG treatments to protect the macrophages from oxidative injury was effective and the macrophage colony-stimulating factor (M-CSF) exhibited some similar effects. It was speculated that both M-CSF and PSG could protect macrophages from oxidative injury. The results suggested that the effects of PSG were associated with its capability of inducing M-CSF expression.
Qian
Gouying
G
Faculty of Animal Science, Zhejiang University, Zhejiang 310007, China. qgy08@yahoo.co.uk
Xu
Zirong
Z
D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis* / Q000494:pharmacology*; D020122:tert-Butylhydroperoxide / Q000494:pharmacology
D008077:Lipoproteins, LDL; D011135:Polysaccharides, Bacterial; D020122:tert-Butylhydroperoxide