title: Potential for ultrafast protein separations with capillary-channeled polymer (C-CP) fiber columns.
abstract: Capillary-channeled polymer (C-CP) fibers are demonstrated as a potential stationary phase for liquid chromatography separation of protein mixtures. Separation of a synthetic mixture of four proteins is accomplished within a 45-second window using a conventional revered-phase (RP) gradient, at a mobile phase flow rate of 7 mL/min (10,200 mm/min).
authors.affiliation: Department of Chemistry, Biosystems Research Complex, Clemson University, Clemson, SC 29634-0973, USA.
authors.forename: Dwella M
authors.initials: DM
authors.lastname: Nelson
authors.forename: R Kenneth
authors.initials: RK
authors.lastname: Marcus
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011108:Polymers; D011506:Proteins