Cortical bone geometry in asthmatic children.
At the mid-radius, pre-pubertal asthmatic children had smaller periosteal and endosteal circumferences and thicker cortical shells compared to controls, when assessed by peripheral quantitative computed tomography. Asthmatics had diminished periosteal expansion for muscle size, suggesting that asthma, its treatment, or its effects on physical activity had resulted in impaired adaptation of bone to muscle loading. Alterations in cortical bone geometry might explain the increased fracture risk in asthmatic children.
Quick
J L
JL
Department of Paediatric Medicine, Saint Mary's Hospital for Women & Children, Central Manchester & Manchester Children's Hospitals NHS Trust, Manchester, UK.
Ward
K A
KA
Adams
J E
JE
Mughal
M Z
MZ
D001249:Asthma / Q000000981:diagnostic imaging / Q000473:pathology*; D001827:Body Height; D001835:Body Weight; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011884:Radius / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed