Endocarditis associated with antineutrophil cytoplasmic antibodies: a case report and review of the literature.
We report a case of subacute bacterial endocarditis associated with small vessel vasculitis and a strongly positive cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) test. It is important to recognize this cause of positive c-ANCA because infectious endocarditis may closely mimic the clinical manifestations of ANCA-associated vasculitides such as Wegener granulomatosis or microscopic polyangiitis. Furthermore, ANCA-associated vasculitis may result in noninfectious endocarditis, which may be confused with bacterial endocarditis. In this paper, we review reported cases of ANCA-positive bacterial endocarditis and compare them to the reported cases of ANCA-associated idiopathic vasculitis with endocardial compromise.
Chirinos
Julio A
JA
Department of Medicine, University of Miami, School of Medicine and Veterans Affairs Medical Center, Miami, FL, USA. jchirinos@med.miami.edu
Corrales-Medina
Vicente F
VF
Garcia
Santiago
S
Lichtstein
Daniel M
DM
Bisno
Alan L
AL
Chakko
Simon
S
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood* / Q000276:immunology; D001021:Aortic Valve / Q000276:immunology / Q000382:microbiology* / Q000601:surgery; D004698:Endocarditis, Subacute Bacterial / Q000150:complications / Q000276:immunology* / Q000628:therapy; D013293:Enterococcus faecalis / Q000472:pathogenicity*; D016908:Gram-Positive Bacterial Infections / Q000150:complications / Q000382:microbiology* / Q000601:surgery; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged
D019268:Antibodies, Antineutrophil Cytoplasmic