Self-assembly of beta-cyclodextrin in water. Part 1: Cryo-TEM and dynamic and static light scattering.
In this article, we report evidence of beta-cyclodextrin (beta-CD) self-aggregation in water. A critical aggregation concentration (cac) between 2 and 3 mM was determined by using dynamic (DLS) and static (SLS) light scattering to investigate the presence of beta-cyclodextrin aggregates. Transmission electron microscopy at cryogenic temperature (Cryo-TEM) was used to detect the structural features of cyclodextrin self-aggregates. The results show the occurrence of polymorphism depending on the beta-CD concentration: polydisperse nearly spherical objects with diameters of about 100 nm are present at lower concentrations, whereas micrometer planar aggregates are predominant at higher concentrations.
Bonini
Massimo
M
Department of Chemistry and CSGI, University of Florence, 50019 Sesto Fiorentino (Firenze), Italy.
Rossi
Simona
S
Karlsson
Göran
G
Almgren
Mats
M
Lo Nostro
Pierandrea
P
Baglioni
Piero
P
D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D013696:Temperature; D014867:Water / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D047392:beta-Cyclodextrins; D014867:Water; C031215:betadex