The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells.
The photodynamic activity of water soluble mixed sulfonated metallophthalocyanines complexes: GePcSmix, SnPcSmix and SiPcSmix on human oesophageal carcinoma (SNO) cells are reported, and compared with the activity of the unmetallated H2PcSmix and of the newly synthesized water soluble adjacently substituted binaphthalo phthalocyanine (complex 3). The alkaline phosphate (ALP) showed damage to the cell membrane in the presence of complex 3 without irradiation. The GePcSmix complex caused a relatively large increase in inflammation and a high intracellular ATP.
Seotsanyana-Mokhosi
Itumeleng
I
Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa.
Kresfelder
Tina
T
Abrahamse
Heidi
H
Nyokong
Tebello
T
D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D004938:Esophageal Neoplasms / Q000473:pathology*; D005857:Germanium; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D054833:Isoindoles; D013058:Mass Spectrometry; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D017646:Organosilicon Compounds / Q000737:chemistry / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D012822:Silicon Dioxide; D012996:Solutions; D013053:Spectrophotometry; D014001:Tin / Q000737:chemistry / Q000494:pharmacology
D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017646:Organosilicon Compounds; D017319:Photosensitizing Agents; D012996:Solutions; D005857:Germanium; C082854:silicon phthalocyanine; C087232:CGP 55398; D014001:Tin; D012822:Silicon Dioxide; C013647:phthalocyanine