title: Synthesis, characterization, and DNA binding of new water-soluble cyclopentadienyl ruthenium(II) complexes incorporating phosphines.
abstract: The new water-soluble ruthenium(II) chiral complexes [RuCpX(L)(L')](n+) (X = Cl, I. L = PPh3; L' = PTA, mPTA; L = L' = PTA, mPTA) (PTA = 1,3,5-triaza-7-phosphaadamantane; mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane) have been synthesized and characterized by NMR and IR spectroscopy and elemental analysis. The salt mPTA(OSO2CF3) was also prepared and fully characterized by spectroscopic techniques. X-ray crystal structures of [RuClCp(PPh3)(PTA)] (2), [RuCpI(PPh3)(PTA)] (3), and [RuCpI(mPTA)(PPh3)](OSO2CF3) (9) have been determined. The binding properties toward DNA of the new hydrosoluble complexes have been studied using the mobility shift assay. The ruthenium chloride complexes interact with DNA depending on the hydrosoluble phosphine bonded to the metal, while the corresponding compounds with iodide, [RuCpI(PTA)2] (1), [RuCpI(PPh3)(PTA)] (3), [RuCpI(mPTA)2](OSO2CF3)2 (6), and [RuCpI(mPTA)(PPh3)](OSO2CF3) (9), do not bind to DNA.
authors.affiliation: Area de Química Inorgánica, Facultad de Ciencias, Universidad de Almería, Almería, Spain. romerosa@ual.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Romerosa
authors.forename: Tatiana
authors.initials: T
authors.lastname: Campos-Malpartida
authors.forename: Chaker
authors.initials: C
authors.lastname: Lidrissi
authors.forename: Mustapha
authors.initials: M
authors.lastname: Saoud
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano-Ruiz
authors.forename: Maurizio
authors.initials: M
authors.lastname: Peruzzini
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Garrido-Cárdenas
authors.forename: Federico
authors.initials: F
authors.lastname: García-Maroto
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D012995:Solubility; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D003517:Cyclopentanes; D008024:Ligands; D009942:Organometallic Compounds; D010720:Phosphines; D014867:Water; D012428:Ruthenium; D004247:DNA