title: A porphyrin increases survival time of mice after intracerebral prion infection.
abstract: Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
authors.affiliation: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA. DKocisko@niaid.nih.gov
authors.forename: David A
authors.initials: DA
authors.lastname: Kocisko
authors.forename: Winslow S
authors.initials: WS
authors.lastname: Caughey
authors.forename: Richard E
authors.initials: RE
authors.lastname: Race
authors.forename: Grant
authors.initials: G
authors.lastname: Roper
authors.forename: Byron
authors.initials: B
authors.lastname: Caughey
authors.forename: John D
authors.initials: JD
authors.lastname: Morrey
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D051379:Mice; D008822:Mice, Transgenic; D011166:Porphyrins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017096:Prion Diseases / Q000188:drug therapy*
chemical_list: D011166:Porphyrins; C016136:tetraphenylporphine sulfonate