A role for neurotrophins in embryonic stem cell growth.
Neurotrophins act on embryonic cells through TRK receptors to inhibit apoptosis by phosphorylation of AKT. In a recent paper in Nature Biotechnology, show that the presence of selected neurotrophins enables cloning of trypsinized single embryonic stem cells and potentially increases the availability and usefulness of these stem cells.
Trounson
Alan
A
Monash Immunology and Stem Cell Laboratories, Monash University, Building 75, Clayton, Victoria 3800, Australia. alan.trounson@med.monash.edu.au
Pebay
Alice
A
D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D019976:Cloning, Organism; D006801:Humans; D008954:Models, Biological; D009414:Nerve Growth Factors / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*; D015398:Signal Transduction
D009414:Nerve Growth Factors