title: Endocarditis associated with antineutrophil cytoplasmic antibodies: a case report and review of the literature.
abstract: We report a case of subacute bacterial endocarditis associated with small vessel vasculitis and a strongly positive cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) test. It is important to recognize this cause of positive c-ANCA because infectious endocarditis may closely mimic the clinical manifestations of ANCA-associated vasculitides such as Wegener granulomatosis or microscopic polyangiitis. Furthermore, ANCA-associated vasculitis may result in noninfectious endocarditis, which may be confused with bacterial endocarditis. In this paper, we review reported cases of ANCA-positive bacterial endocarditis and compare them to the reported cases of ANCA-associated idiopathic vasculitis with endocardial compromise.
authors.affiliation: Department of Medicine, University of Miami, School of Medicine and Veterans Affairs Medical Center, Miami, FL, USA. jchirinos@med.miami.edu
authors.forename: Julio A
authors.initials: JA
authors.lastname: Chirinos
authors.forename: Vicente F
authors.initials: VF
authors.lastname: Corrales-Medina
authors.forename: Santiago
authors.initials: S
authors.lastname: Garcia
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Lichtstein
authors.forename: Alan L
authors.initials: AL
authors.lastname: Bisno
authors.forename: Simon
authors.initials: S
authors.lastname: Chakko
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood* / Q000276:immunology; D001021:Aortic Valve / Q000276:immunology / Q000382:microbiology* / Q000601:surgery; D004698:Endocarditis, Subacute Bacterial / Q000150:complications / Q000276:immunology* / Q000628:therapy; D013293:Enterococcus faecalis / Q000472:pathogenicity*; D016908:Gram-Positive Bacterial Infections / Q000150:complications / Q000382:microbiology* / Q000601:surgery; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic