Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
The marine alkaloid variolin B 2 and eight synthetic derivatives with different substituents at positions C-5 and C-7 have been tested in a panel of sixteen human tumor cell lines to evaluate their cytotoxic potential.
Fresneda
Pilar M
PM
Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 30100-Murcia, Spain. fresnada@um.es
Delgado
Santiago
S
Francesch
Andrés
A
Manzanares
Ignacio
I
Cuevas
Carmen
C
Molina
Pedro
P
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D011161:Porifera / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000970:Antineoplastic Agents; D001372:Aza Compounds; D006146:Guanidines; D011743:Pyrimidines; C474921:variolin B