Incidence of monoclonal B-cell disease in siblings of patients with multiple myeloma.
We observed clustering of monoclonal B-cell disease in siblings being screened as allogeneic donors for patients with multiple myeloma (MM) scheduled for stem cell transplantation (SCT). Of 134 asymptomatic donors, the incidence of monoclonal B-cell disease was 8/84 in siblings and 1/50 in matched unrelated donors. From an analysis of five MM families scheduled for allogeneic SCT, monoclonal B-cell disease was detected in 8/27 siblings.
Engelhardt
Monika
M
Ihorst
Gabriele
G
Behringer
Dirk
D
Finke
Jürgen
J
Roth
Birgit
B
D001402:B-Lymphocytes / Q000473:pathology*; D002999:Clone Cells / Q000473:pathology; D005192:Family Health; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D009101:Multiple Myeloma / Q000473:pathology*; D035781:Siblings; D014019:Tissue Donors