Antimalarial activity of methylpiperazinyl-substituted benzophenone-based farnesyltransferase inhibitors.
Kettler
K
K
Department für Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Germany.
Wiesner
J
J
Ortmann
R
R
Dahse
H M
HM
Jomaa
H
H
Schlitzer
M
M
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors*; D005982:Glutathione Transferase / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
D000962:Antimalarials; D001577:Benzophenones; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D010879:Piperazines; D005982:Glutathione Transferase; D051231:Farnesyltranstransferase