Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.
Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log10) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.
Hamelin
Marie-Eve
ME
Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec, Sainte-Foy, Québec, Canada.
Prince
Gregory A
GA
Boivin
Guy
G
D000818:Animals; D003345:Corticosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D008168:Lung / Q000473:pathology; D029121:Metapneumovirus; D051379:Mice; D008807:Mice, Inbred BALB C; D018184:Paramyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*
D012254:Ribavirin; D003345:Corticosterone