title: A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine.
abstract: [reaction: see text]. A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine with aliphatic secondary amines and aromatic amines has been developed which strongly favors the formation of the C4-substituted product. The reactions with aliphatic amines are carried out using LiHMDS as the base and are catalyzed by Pd, while the aromatic amines require no catalyst.
authors.affiliation: Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. zhihui_peng@merck.com
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Peng
authors.forename: Michel
authors.initials: M
authors.lastname: Journet
authors.forename: Guy
authors.initials: G
authors.lastname: Humphrey