Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC.
The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.
Rojas
Rosario
R
Departamento de Ciencias Farmacéuticas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
Bustamante
Betty
B
Ventosilla
Palmira
P
Fernádez
Irma
I
Caviedes
Luz
L
Gilman
Robert Henry
RH
Lock
Olga
O
Hammond
Gerald Bruce
GB
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology*; D001681:Biological Assay; D003465:Culex; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010568:Peru; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D000995:Antitubercular Agents; D007306:Insecticides