title: Therapeutic potentials of a novel method of dual-pulse gastric electrical stimulation for gastric dysrhythmia and symptoms of nausea and vomiting.
abstract: BACKGROUND
  The aims of this study were to investigate the effects and mechanisms of a novel method of gastric electrical stimulation on the prevention of vasopressin-induced emetic response and gastric dysrhythmias.
  
  
  METHODS
  Fifteen dogs (10 normal, 5 vagotomized) chronically implanted with gastric serosal electrodes were used in a 3-session study (vasopressin, vasopressin plus 2-channel stimulation [DCS], and vasopressin plus dual-pulse stimulation [DPS]).
  
  
  RESULTS
  Vasopressin induced gastric dysrhythmias and motion sickness-like symptoms (P < .05) and these effects were blocked partially with vagotomy. Both methods of DCS and DPS were capable of preventing vasopressin-induced gastric dysrhythmias (P < .05) and motion sickness-like symptoms (P < .05). The antiemetic effects of the proposed methods of DCS and DPS were abolished by vagotomy but their antidysrhythmic effects were not blocked by vagotomy.
  
  
  CONCLUSIONS
  DCS and DPS are able to reduce vasopressin-induced gastric dysrhythmia and symptoms of nausea and vomiting. The vagal pathway is involved in the antiemetic effect but not the antidysrhythmic effect of the proposed methods of stimulation.
authors.affiliation: Division of Gastroenterology, University of Texas Medical Branch, GI Research, Route 0632, Room 221, Microbiology Building, 1108 The Strand, Galveston, TX 77555-0632, USA.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
authors.forename: Xian
authors.initials: X
authors.lastname: Qiao
authors.forename: Jiande D Z
authors.initials: JD
authors.lastname: Chen
mesh_terms: D000818:Animals; D004285:Dogs; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D009325:Nausea / Q000628:therapy*; D013270:Stomach / Q000502:physiology*; D013272:Stomach Diseases / Q000628:therapy*; D014628:Vagotomy; D014667:Vasopressins / Q000494:pharmacology; D014839:Vomiting / Q000628:therapy*
chemical_list: D014667:Vasopressins