title: Failure of a 5-day course of intramuscular ceftriaxone to eradicate Streptococcus pneumoniae from the middle ear.
abstract: A 10-kg 9-month-old infant with recurrent, unresponsive otitis media presented with bilateral acute otitis media caused by Streptococcus pneumoniae type 19A, resistant to all oral agents and intermediately susceptible to ceftriaxone. Treatment with myringotomies and intramuscular ceftriaxone, 50 mg/kg/d for 5 days, was unsuccessful. The patient responded to pressure equalization tubes and local ciprofloxacin with dexamethasone drops.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, Erie, PA, USA.
authors.forename: Jack B
authors.initials: JB
authors.lastname: Anon
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Ripple
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018550:Cephalosporin Resistance; D004432:Ear, Middle / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D010033:Otitis Media / Q000188:drug therapy* / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone