Cardiovascular and metabolic effects of natriuretic peptides.
Natriuretic peptides (NP) are essential in mammals to regulate blood volume and pressure. The functional roles of NP are not limited to natriuresis and diuresis. Several peripheral and central actions of the peptides have been characterized. Studies on transgenic mice have revealed their key function in the regulation of cardiomyocyte growth. Plasma NP levels increase in patients with cardiovascular disorders and heart failure. They represent useful clinical markers for clinicians to diagnose heart diseases. The recent discovery of their potent lipolytic action in adipose tissue is a breakthrough in cardiovascular medicine. This new function of NP in the regulation of lipid metabolism offers interesting questions in the field of obesity, diabetes and cardiovascular diseases. This review will briefly describe the effects of NP on the cardiovascular system and lipid metabolism.
Moro
Cédric
C
Department of Medical and Clinical Pharmacology, Faculty of Medicine, Toulouse, France. moro@cict.fr
Berlan
Michel
M
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002319:Cardiovascular System / Q000378:metabolism*; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D050356:Lipid Metabolism; D015201:Meta-Analysis as Topic; D020097:Natriuretic Peptide, Brain / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D045265:Natriuretic Peptides / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D009765:Obesity / Q000097:blood / Q000378:metabolism; D017461:Receptors, Atrial Natriuretic Factor / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction
D015415:Biomarkers; D045265:Natriuretic Peptides; D020097:Natriuretic Peptide, Brain; D017461:Receptors, Atrial Natriuretic Factor