How to quantify information loss due to phase ambiguity in haplotype case-control studies.
Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information.
Uh
Hae-Won
HW
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands. h.uh@lumc.nl
Houwing-Duistermaat
Jeanine J
JJ
Putter
Hein
H
van Houwelingen
Hans C
HC
D016022:Case-Control Studies; D006239:Haplotypes / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans