Determinants of bronchodilator responsiveness in patients with controlled asthma.
Short-term bronchodilator responsiveness to an inhaled ss 2 adrenergic agonist was assessed by changes in forced expiratory volume in 1 second (FEV(1)) in nonsmoking adults with controlled asthma (mild disease, 20 patients; moderate disease, 20 patients; severe disease, 18 patients). Responsiveness correlated significantly with age and with percent of predicted FEV(1) (%FEV(1)) except in patients with severe asthma, who showed significantly less responsiveness than others. Thus, responsiveness is closely associated with degree of airflow limitation in patients with controlled asthma and is significantly influenced by severity of disease and by aging.
Koga
Takeharu
T
First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan. kogat@med.kurume-u.ac.jp
Kamimura
Tomoko
T
Oshita
Yuichi
Y
Narita
Yuko
Y
Mukaino
Tatsuya
T
Nishimura
Munetsugu
M
Mizoguchi
Yusuke
Y
Aizawa
Hisamichi
H
D000328:Adult; D000367:Age Factors; D000368:Aged; D000420:Albuterol / Q000494:pharmacology; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000494:pharmacology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology; D012123:Pulmonary Ventilation / Q000187:drug effects / Q000502:physiology; D013147:Spirometry
D001993:Bronchodilator Agents; D000420:Albuterol