Hinged molecular capsules: synthesis and conformational control via temperature, pH, or solvent composition.
Three new covalently linked molecular capsules were synthesized from their resorcinarene cavitand precursors in good yields. The capsules undergo reversible conformational switching between the closed "vase" form and the open "kite" form upon temperature or pH variation. The kite conformation obtained via either method in CDCl(3) switches to vase conformation upon addition of polar solvents such as acetone-d(6) or THF-d(8).
Kang
Sang-Woo
SW
Department of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA.
Castro
Peter P
PP
Zhao
Gang
G
Nuñez
Jose E
JE
Godinez
Carlos E
CE
Gutierrez-Tunstad
Linda M
LM
D047250:Calixarenes; D002214:Capsules / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D012997:Solvents; D013696:Temperature
D002214:Capsules; D012997:Solvents; C466160:resorcinarene; D047250:Calixarenes; D010649:Phenylalanine