[Clinical effect of treatment for clearing heat, detoxicating and nourishing Yin on patients with glucocorticosteroid induced facial dermatitis and its effect on skin barrier function].
OBJECTIVE
To observe the clinical efficacy of treatment for clearing heat, detoxicating and nourishing Yin (abbr. as CHM) on glucocorticosteroid (GCS) induced facial dermatitis, and its effect in repairing skin barrier function.


METHODS
One hundred and fifteen patients were randomly assigned into two groups, 68 in the treated group treated with CHM and 47 in the control group treated by oral administration of loratadine 10 mg once a day and ketotifen 1 mg once every night. The volume of transepidermal water loss (TEWL) of patients was measured before and after treatment.


RESULTS
The effective rate was 77.9% (53/68) and 14.9% (7/47) in the treated group and the control group respectively, showing significant difference between the two groups, and it was better in the treated group than that in the control group (P < 0.01). The decrease of TEWL in the treated group was also superior to that in the control group (P < 0.01).


CONCLUSIONS
Chinese herbal treatment for clearing heat, detoxicating and nourishing Yin has significant clinical efficiency on GCS induced facial dermatitis and in repairing the skin barrier function.
Du
Xiao-Hang
XH
Department of Dermatology, The Third People's Hospital of Hangzhou, Zhejiang. duxiaohang@126.com
Song
Wei-Min
WM
Xu
Ai-E
AE
D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy; D012869:Skin Absorption; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D016710:Yin Deficiency / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids