title: Corticospinal tract conduction block results in the prolongation of central motor conduction time in compressive cervical myelopathy.
abstract: OBJECTIVE
  The objective of this study was to analyze corticospinal function in patients with compressive cervical myelopathy and to elucidate the mechanism underlying its prolonged central motor conduction time (CMCT).
  
  
  METHODS
  Motor evoked potentials following transcranial magnetic stimulation (TMS) and peripheral conduction time in the ulnar and tibial nerves following electrical stimulation were measured from the abductor digiti minimi (ADM) and abductor hallucis (AH) muscles in 24 patients with compressive cervical myelopathy and used to calculate CMCT. Spinal cord evoked potentials (SCEPs) following transcranial electric stimulation were recorded intraoperatively from the C2-3 to C6-7 intervertebral levels. Correlations between prolonged CMCT and SCEP values were then estimated.
  
  
  RESULTS
  The shorter/longer CMCT between the patients' right and left ADM and AH were 8.5+/-2.9/11.5+/-3.3 and 16.2+/-3.1/18.4+/-3.3 ms, respectively (mean+/-SD). The SCEPs amplitude at C6-7, compared to C2-3, was 25.7+/-21.0%. The attenuation of SCEP amplitude, but not latency, at C6-7 correlated significantly with CMCT prolongation.
  
  
  CONCLUSIONS
  Our data support the view that CMCT prolongation is primarily due to corticospinal conduction block, rather than conduction delay.
  
  
  CONCLUSIONS
  Insight was provided into the mechanism of corticospinal dysfunction in compressive cervical myelopathy.
authors.affiliation: Programs for Applied Biomedicine, Division of Clinical Medical Science, Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8551, Japan. kazn@hiroshima-u.ac.jp
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tanaka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Naosuke
authors.initials: N
authors.lastname: Kamei
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
mesh_terms: D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002574:Cervical Vertebrae; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology* / Q000528:radiation effects; D011712:Pyramidal Tracts / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology* / Q000528:radiation effects; D012189:Retrospective Studies; D013117:Spinal Cord Compression / Q000503:physiopathology*