title: Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention.
abstract: Worldwide, hepatitis B virus (HBV) is the most common among those hepatitis viruses that cause chronic infections of the liver in humans, and it represents a global public health problem. Chronic hepatitis caused by HBV is the major cause of hepatocellular carcinoma (HCC) worldwide, and remains therefore a major public health problem globally. This fact is related to both the continuing occurrence of frequent new infections and to the presence of a large reservoir of persons chronically infected, which may develop severe and fatal complications of chronic liver disease. Hepatitis B and all of the complications resulting from it, as well hepatitis D (HDV) and its complications, are globally preventable by hepatitis B vaccination, and therefore elimination of HBV transmission and of new acute and chronic infections is a feasible goal.
authors.affiliation: World Health Organization, Department of Communicable Diseases Surveillance and Response, Geneva, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Lavanchy
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology / Q000821:virology*; D006509:Hepatitis B / Q000150:complications / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006801:Humans
chemical_list: D017325:Hepatitis B Vaccines