Resistance exercise training attenuates alcohol-induced cardiac oxidative stress.
BACKGROUND
Myocardial oxidative stress is believed to play an important role in the pathogenesis of alcoholic cardiomyopathy. Strenuous physical exercise has been shown to increase or decrease myocardial oxidative stress depending on the mode and duration of the exercise intervention. Given the possibility of individuals to engage in both alcohol consumption and weight-training exercise, we have examined the effect of resistance exercise training and chronic alcohol consumption on myocardial oxidative stress in rats.


METHODS
Forty Sprague-Dawley rats were randomly assigned to one of four experimental groups: sedentary, sedentary plus alcohol treatment, resistance training, or resistance training plus alcohol treatment. Rats in the alcohol groups received a liquid diet containing alcohol (35% of kilocalorie intake) for 6 weeks. Non-alcohol groups were pair-fed the same liquid diet supplemented with a maltose dextrin caloric substitute. Rats in the resistance training groups were trained to rise onto their hind limbs while wearing lead-weighted vests 30 times per training session, 3 days per week during the 6 week experimental period.


RESULTS
Alcohol treatment in the sedentary animals resulted in greater levels of cardiac malondialdehyde, a marker of lipid peroxidation, and a depressed index of myocardial antioxidant potential compared with all other groups (P<0.05). Hearts from the resistance training plus alcohol animals exhibited malondialdehyde and antioxidant levels similar to sedentary controls, suggesting that resistance training protected against the alcohol-induced myocardial stress.


CONCLUSIONS
These results suggest that resistance training may attenuate the damaging effects of alcohol on the heart and preserve myocardial antioxidant capacity.
Chicco
Adam J
AJ
School of Sport and Exercise Science, University of Northern Colorado Greeley, Denver, CO, USA.
McCarty
Heidi
H
Reed
Adam H
AH
Story
Regan R
RR
Westerlind
Kim C
KC
Turner
Russell T
RT
Hayward
Reid
R
D000222:Adaptation, Physiological / Q000502:physiology; D000434:Alcoholic Beverages / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D000431:Ethanol / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000975:Antioxidants; D002492:Central Nervous System Depressants; D000431:Ethanol; D008315:Malondialdehyde