title: Efficacy of quinolones against secondary pneumococcal pneumonia after influenza virus infection in mice.
abstract: We established a mouse model of secondary pneumococcal pneumonia after influenza virus infection and investigated the efficacy of several quinolones against pneumonia in this model. Gatifloxacin exhibited the highest efficacy among the quinolones examined and is probably useful for the treatment of secondary bacterial pneumonia.
authors.affiliation: Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Shimotsuga, Tochigi 329-0114, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Shin-etsu
authors.initials: SE
authors.lastname: Kadowaki
authors.forename: Masaya
authors.initials: M
authors.lastname: Takei
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Fukuda
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D000077734:Gatifloxacin; D008168:Lung / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D015242:Ofloxacin / Q000627:therapeutic use*; D009976:Orthomyxoviridae Infections / Q000150:complications*; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D015242:Ofloxacin; D000077734:Gatifloxacin