title: Early onset parkinsonism in dementia lacking distinct histopathological features.
abstract: Dementia lacking distinct histopathological features (DLDHF) belongs to the frontotemporal dementia syndromes. Behavioral, cognitive and motor symptoms are its usual clinical manifestations. However, considerable heterogeneity exists and no evident clinicopathological correlations can be performed. We report a patient who presented with a very unusual combination of behavioral abnormalities and prominent early parkinsonism progressing to a severe dementia. Pathological studies confirmed DLDHF with severe frontal and striatal neuronal loss and gliosis.
authors.affiliation: Department of Neurology, Bidasoa Hospital, Hondarribia, Spain. abergarechey@meditex.es
authors.forename: A
authors.initials: A
authors.lastname: Bergareche
authors.forename: J F
authors.initials: JF
authors.lastname: Martí-Massó
authors.forename: G
authors.initials: G
authors.lastname: Linacasoro
authors.forename: J M
authors.initials: JM
authors.lastname: Arrinda
authors.forename: A
authors.initials: A
authors.lastname: De Arce
mesh_terms: D017668:Age of Onset; D001921:Brain / Q000473:pathology*; D003704:Dementia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology