Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.
The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
Fujita
Masaki
M
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812, Japan. fujita@kokyu.med.kyushu-u.ac.jp
Ye
Qing
Q
Ouchi
Hiroshi
H
Harada
Eiji
E
Inoshima
Ichiro
I
Kuwano
Kazuyoshi
K
Nakanishi
Yoichi
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000633:toxicity*; D004318:Doxycycline / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D001761:Bleomycin; D004318:Doxycycline