[Endocrine sequelae after radiotherapy in childhood and adolescence].
Radiotherapy may result in endocrine abnormalities, osteoporosis, obesity and neurological sequelae in patients treated for cancer. In the hypothalamo-pituitary area, GH deficiency is the most frequent complication. The frequency, delay of appearance and severity of GH deficiency depend most on the dose delivered during cranial irradiation but variables as age at treatment and fractionation schedule may play an important role as well. Other hypothalamo-pituitary dysfunctions are also dose-dependent. Low dose cranial irradiation may induce precocious or early puberty, while high doses are related to gonadotropin deficiency. Endocrine complications due to extracranial irradiation such as gonadal or thyroid abnormalities are described. In spite of normal GH secretion, linear growth may be impaired by bone lesions secondary to craniospinal or total body irradiation. Results on final height have been optimized by better indicators of GH therapy associated with adequate treatment of early or precocious puberty. The purpose of this review is to explore the late endocrine sequelae of radiotherapy.
Couto-Silva
Ana Cláudia
AC
Universidade Federal da Bahia, Salvador, BA.
Brauner
Raja
R
Adan
Luís Fernando
LF
D000293:Adolescent; D002648:Child; D004700:Endocrine System Diseases / Q000209:etiology*; D006130:Growth Disorders / Q000209:etiology*; D013006:Growth Hormone / Q000172:deficiency / Q000528:radiation effects*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000528:radiation effects*; D009369:Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage
D013006:Growth Hormone