N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis.
In this report, we describe a new family of N-thiolated 2-oxazolidinones having antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus anthracis. The effect of ring substituents and stereochemistry on antibacterial activity of these oxazolidinones closely parallels that previously reported for N-thiolated beta-lactam antibiotics.
Mishra
Rajesh Kumar
RK
Department of Chemistry, 4202 East Fowler Avenue, University of South Florida, Tampa, FL 33620, USA.
Revell
Kevin D
KD
Coates
Cristina M
CM
Turos
Edward
E
Dickey
Sonja
S
Lim
Daniel V
DV
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013438:Sulfhydryl Compounds; D047090:beta-Lactams