title: PNA-based reagents for the direct and site-specific synthesis of thymine dimer lesions in genomic DNA.
abstract: An acetophenone containing PNA-based reagent was designed for the direct and site-specific synthesis of a cis-syn thymidine dimer lesion in genomic DNA.
authors.affiliation: Department of Chemistry and Biochemistry, Ludwig-Maximilians University, Butenandtstr. 5-13, 83177 Munich, Germany.
authors.forename: J Carsten
authors.initials: JC
authors.lastname: Pieck
authors.forename: David
authors.initials: D
authors.lastname: Kuch
authors.forename: Friederike
authors.initials: F
authors.lastname: Grolle
authors.forename: Uwe
authors.initials: U
authors.lastname: Linne
authors.forename: Clemens
authors.initials: C
authors.lastname: Haas
authors.forename: Thomas
authors.initials: T
authors.lastname: Carell
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis / Q000737:chemistry*; D001435:Bacteriophages / Q000235:genetics; D001483:Base Sequence; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific / Q000737:chemistry; D006735:Horseradish Peroxidase / Q000737:chemistry; D008969:Molecular Sequence Data; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011740:Pyrimidine Dimers / Q000138:chemical synthesis*; D019809:Streptavidin / Q000737:chemistry; D013379:Substrate Specificity
chemical_list: D000098:Acetophenones; D020135:Peptide Nucleic Acids; D011740:Pyrimidine Dimers; D004247:DNA; D019809:Streptavidin; D006735:Horseradish Peroxidase; C061224:endodeoxyribonuclease PvuI; D015252:Deoxyribonucleases, Type II Site-Specific; C038699:acetophenone