Persistent neuroinvasive West Nile virus infection in an immunocompromised patient.
A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.
Penn
Robert G
RG
Department of Epidemiology, Methodist Hospital, Omaha, Nebraska, USA.
Guarner
Jeannette
J
Sejvar
James J
JJ
Hartman
Herbert
H
McComb
Rodney D
RD
Nevins
Diana L
DL
Bhatnagar
Julu
J
Zaki
Sherif R
SR
D000956:Antigens, Viral / Q000302:isolation & purification; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007136:Immunoglobulins / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000302:isolation & purification; D014901:West Nile Fever / Q000188:drug therapy / Q000276:immunology*
D000956:Antigens, Viral; D007136:Immunoglobulins; D012367:RNA, Viral