title: Remission of aplastic anemia induced by treatment for Graves disease in a pediatric patient.
abstract: Aplastic anemia (AA) is mediated by T-cell autoimmunity in the majority of cases; it is rare and mostly idiopathic in children. We describe a child, who developed AA following Graves' disease which could not be attributed to antithyroid drugs. We hypothesized that both diseases were caused by similar autoimmune process. We monitored the blood counts and did not administer any conventional treatment for AA assuming that the existing anti- hematopoietic stem cell humoral and cellular immunity might subside with induction of remission of Grave's disease. The child went into complete remission with the treatment of the Graves' disease.
authors.affiliation: Department of Pediatrics, Division of Hematology Oncology, University of Toronto, Toronto, Canada.
authors.forename: Prabodh Kumar
authors.initials: PK
authors.lastname: Das
authors.forename: Diane
authors.initials: D
authors.lastname: Wherrett
authors.forename: Yigal
authors.initials: Y
authors.lastname: Dror
mesh_terms: D000741:Anemia, Aplastic / Q000209:etiology* / Q000473:pathology; D013956:Antithyroid Agents / Q000627:therapeutic use; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000532:radiotherapy*; D020249:Hormone Replacement Therapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008713:Methimazole / Q000627:therapeutic use; D010198:Pancytopenia / Q000097:blood / Q000209:etiology / Q000473:pathology; D012008:Recurrence; D012074:Remission Induction; D013971:Thyrotoxicosis / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy; D013974:Thyroxine / Q000627:therapeutic use; D016312:Treatment Refusal
chemical_list: D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D008713:Methimazole; D013974:Thyroxine