title: [Prophylactic use of droperidol for postoperative nausea and vomiting following gynecological laparoscopic surgery under total intravenous anesthesia].
abstract: BACKGROUND
  Propofol and droperidol decrease the incidence of postoperative nausea and vomiting (PONV). We investigated the incidence of PONV after total intravenous anesthesia (TIVA) with propofol alone versus combined use of droperidol and propofol.
  
  
  METHODS
  Eighty three patients, who had undergone laparoscopic gynecologic surgery with TIVA using propofol and fentanyl, were retrospectively evaluated whether droperidol had affected the incidence of early (up to six hours postoperatively) and late (6-24 hours postoperatively) PONV. Group D (46 patients) received droperidol intravenously at the end of surgery. Group N (37 patients) received no droperidol.
  
  
  RESULTS
  The incidences of early nausea were 27% in Group N and 4% in Group D (P<0.01). The incidences of early vomiting were 0% in Group N and 8% in Group D. The incidences of late nausea were 14% in Group N and 13% in Group D. The incidences of late vomiting were 3% in Group N and 7% in Group D.
  
  
  CONCLUSIONS
  Droperidol was useful in reducing the incidence of early nausea and vomiting after total intravenous anesthesia with propofol and fentanyl in the patients undergoing laparoscopic surgery.
authors.affiliation: Nara Emergency and Critical Care Medical Center, Nara Prefectural Nara Hospital, Nara 631 0846.
authors.forename: Masayo
authors.initials: M
authors.lastname: Morioka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kumatoriya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morooka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Watanabe
authors.forename: Junko
authors.initials: J
authors.lastname: Tayama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Shimomura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Furuya
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000932:Antiemetics / Q000008:administration & dosage*; D004329:Droperidol / Q000008:administration & dosage*; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000209:etiology* / Q000517:prevention & control*; D011229:Preanesthetic Medication; D015742:Propofol / Q000009:adverse effects*
chemical_list: D018686:Anesthetics, Intravenous; D000932:Antiemetics; D004329:Droperidol; D005283:Fentanyl; D015742:Propofol