bcr-abl-positive T-cell acute lymphoblastic leukemia associated with parvovirus B19 infection.
The authors report an unusual presentation of a Philadelphia chromosome-positive acute lymphoblastic leukemia with two unusual features: a bcr-abl fusion mRNA coding for p210 protein and a T-cell immunophenotype. The patient was a 16-year-old boy who presented with septic shock and pancytopenia, likely precipitated by an acute parvovirus B19 infection. Management consisted of supportive therapy, followed by chemotherapy for T-cell acute lymphoblastic leukemia and stem cell transplantation. He died 8 months after transplant due to idiopathic pneumonia syndrome, but without evidence of relapsed disease.
Abla
Oussama
O
The Hospital for Sick Children, Toronto, Ontario, Canada. oussama.abla@sickkids.ca
Gassas
Adam
A
Stevens
Robert
R
Grant
Ronald
R
Abdelhaleem
Mohamed
M
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D001853:Bone Marrow / Q000821:virology; D002543:Cerebral Hemorrhage / Q000209:etiology; D003131:Combined Modality Therapy; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D017809:Fatal Outcome; D016044:Fusion Proteins, bcr-abl / Q000097:blood; D016313:Genes, abl; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009102:Multiple Organ Failure / Q000209:etiology; D009363:Neoplasm Proteins / Q000097:blood; D010198:Pancytopenia / Q000209:etiology; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D010677:Philadelphia Chromosome; D011014:Pneumonia / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D011241:Prednisone / Q000008:administration & dosage; D011289:Preleukemia / Q000150:complications*; D012772:Shock, Septic / Q000209:etiology; D013203:Staphylococcal Infections / Q000150:complications; D014750:Vincristine / Q000008:administration & dosage
D009363:Neoplasm Proteins; D014750:Vincristine; D016044:Fusion Proteins, bcr-abl; D001215:Asparaginase; D011241:Prednisone; D008727:Methotrexate