Unlikely partners in weight loss?
The classic role of bile acids is as a key component of cholesterol homeostasis. New evidence recently published in Nature (Watanabe et al., 2006), however, describes a bile acid signaling pathway that controls energy expenditure through induction of thyroid hormone signaling pathways. This work may point to new approaches to tissue-specific metabolic regulation.
Wondisford
Fredric E
FE
Division of Metabolism, Department of Pediatrics, Johns Hopkins University Medical School, Baltimore, Maryland 21287, USA.
D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology*
D001647:Bile Acids and Salts; D013963:Thyroid Hormones; D002784:Cholesterol