The pivotal nature of sugars in normal physiology and disease.
Glycopathology has become the focus of considerable research in recent years as the role of glycosylation in the development, regulation, and progression of disease has come under increased scrutiny. Cracking the 'sugar-code' in biological systems that relate to both health and disease holds tremendous promise for deciphering disease mechanisms such as the link between the glycomodification of immunoglobulins and various autoimmune diseases, notably IgG in rheumatoid arthritis (RA), and has exciting implications for the development of novel diagnostic and therapeutic interventions.
Alavi
Azita
A
The Sir Joseph Hotung Centre for Musculoskeletal Diseases, St George's University of London, London, United Kingdom. aalavi@sgul.ac.uk
Axford
John S
JS
D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000503:physiopathology; D002241:Carbohydrates / Q000502:physiology*; D003198:Computer Simulation; D006031:Glycosylation; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000235:genetics; D007074:Immunoglobulin G / Q000097:blood / Q000235:genetics*; D008957:Models, Genetic; D011499:Protein Processing, Post-Translational / Q000235:genetics; D013583:Synovial Membrane / Q000276:immunology
D002241:Carbohydrates; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G