Genetic mouse models of Alzheimer's disease.
In the current minireview, we focus on genetic mouse models of Alzheimer's disease (AD). Because various excellent, up-to-date reviews, special issues, and reliable websites are already dedicated to the genetics of Alzheimer's disease in general and of animal models in particular, this review is not meant to be comprehensive. Rather, we aim to steer the Alzheimer's novice through the recent mouse literature on AD. Special attention will be paid to genetic models that have been tested behaviorally.
Mineur
Yann S
YS
Yale School of Medicine, Department of Psychiatry, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA. yann.mineur@yale.edu
McLoughlin
Declan
D
Crusio
Wim E
WE
Sluyter
Frans
F
D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D053829:Amyloid Precursor Protein Secretases; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D004195:Disease Models, Animal; D010450:Endopeptidases / Q000235:genetics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016875:tau Proteins / Q000235:genetics
D016875:tau Proteins; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse