title: A quantitative near-infrared spectroscopy study: a decrease in cerebral hemoglobin oxygenation in Alzheimer's disease and mild cognitive impairment.
abstract: A newly developed quantitative near-infrared spectroscopy (NIRS) system was used to measure changes in cortical hemoglobin oxygenation during the Verbal Fluency Task in 32 healthy controls, 15 subjects with mild cognitive impairment (MCI), and 15 patients with Alzheimer's disease (AD). The amplitude of changes in the waveform, which was quantitatively calculated by a signal processing method, was significantly lower in the frontal, and the bilateral parietal areas in the AD group, whereas that in the MCI group was significantly lower only in the right parietal area. The NIRS system may be a potential tool for the primary screening of AD.
authors.affiliation: Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. heii@med.juntendo.ac.jp
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
authors.forename: Maki
authors.initials: M
authors.lastname: Takano
authors.forename: Koichi
authors.initials: K
authors.lastname: Miyakawa
authors.forename: Tsuneyoshi
authors.initials: T
authors.lastname: Ota
authors.forename: Tadashi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Asaka
authors.forename: Tsuneaki
authors.initials: T
authors.lastname: Kawaguchi
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D013055:Spectrophotometry, Infrared / Q000379:methods*; D014705:Verbal Behavior
chemical_list: D006454:Hemoglobins; D010100:Oxygen