title: Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis.
abstract: The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.
authors.affiliation: Division of Infectious Diseases, Brigham & Women's Hospital, 75 Francis Street, PBB-A4, Boston, MA 02115, USA. fmarty@partners.org
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Marty
authors.forename: Wendy W
authors.initials: WW
authors.lastname: Yeh
authors.forename: Christine B
authors.initials: CB
authors.lastname: Wennersten
authors.forename: Lata
authors.initials: L
authors.lastname: Venkataraman
authors.forename: Esperanza
authors.initials: E
authors.lastname: Albano
authors.forename: Edwin P
authors.initials: EP
authors.lastname: Alyea
authors.forename: Howard S
authors.initials: HS
authors.lastname: Gold
authors.forename: Lindsey R
authors.initials: LR
authors.lastname: Baden
authors.forename: Satish K
authors.initials: SK
authors.lastname: Pillai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D017576:Daptomycin / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin