title: Pancreatic, hepatic, splenic, and mesenteric mucinous cystic neoplasms (MCN) are lumped together as extra ovarian MCN.
abstract: Mucinous cystic neoplasms (MCN) of the pancreas are mucin-producing cystic tumors with an ovarian-like stroma (OLS). In the present study MCN were obtained from 27 patients. These MCN were derived from 22 pancreas, three livers, spleen, and mesentery. MCN in various organs have common clinicopathological profiles, being unilocular or multilocular cystic tumors, with a fibrous capsule and lined by mucin-secreting epithelium associated with an underlying subepithelial OLS. The OLS showed strong positivity for alpha-smooth muscle actin (alpha-SMA) and vimentin and weak, focal positivity for desmin. Both estrogen receptors and progesterone receptors were expressed in the nuclei of OLS cells. In addition, 20 ovarian MCN and 13 normal ovaries were studied with particular attention to the stroma. The stroma of ovarian MCN was strongly immunopositive for alpha-SMA and vimentin and focally positive for desmin, whereas normal ovarian stroma was immunonegative for both alpha-SMA and desmin. The OLS of MCN mentioned here was similar to the septa of ovarian MCN but not to ovarian stroma. In conclusion, MCN in various organs should be lumped together as 'extra ovarian' MCN. The OLS was identified on the basis of myofibroblastic proliferation both in response to neoplastic development and dependent on hormones.
authors.affiliation: First Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Shiono
authors.forename: Koichi
authors.initials: K
authors.lastname: Suda
authors.forename: Bunsei
authors.initials: B
authors.lastname: Nobukawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Arakawa
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Noriko
authors.initials: N
authors.lastname: Sasahara
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Suzuki
mesh_terms: D000199:Actins / Q000032:analysis; D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003893:Desmin / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008643:Mesentery; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000737:chemistry / Q000473:pathology*; D010053:Ovary / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000737:chemistry / Q000473:pathology*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013160:Splenic Neoplasms / Q000737:chemistry / Q000473:pathology*; D017154:Stromal Cells / Q000737:chemistry / Q000473:pathology; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D003893:Desmin; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014746:Vimentin