title: Immunohistochemical study of the expression of adhesion molecules in ovarian serous neoplasms.
abstract: To clarify possible roles of adhesion molecules including E-cadherin, beta- and gamma-catenin, CD44s, CD44v6, CD56, and CD99 in ovarian serous neoplasms, an immunohistochemical study was undertaken for 23 benign, 40 borderline, and 95 malignant ovarian serous neoplasms using tissue microarray (TMA). Significantly reduced expression of E-cadherin, and overexpression of CD44s, CD56, and CD99 were more frequently observed in adenocarcinomas than in benign and borderline tumors. Expression of CD44v6 and nuclear beta- and gamma-catenin were detected only in borderline tumors and adenocarcinomas. Reduced expression of E-cadherin was also correlated with high tumor grade (P=0.03), presence of peritoneal seeding (P=0.03), and low overall survival rate (P=0.02). Overexpression of CD44s was significantly associated with high tumor grade (P=0.04), advanced stage (P=0.03), and low overall survival rate (P=0.02). CD56 was increasingly expressed in the case of advanced stage (P=0.005) and peritoneal seeding (P=0.001). Nuclear staining for gamma-catenin was correlated with tumor progression (P=0.004) and advanced International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.02). Only CD44s expression and stage were correlated with overall survival in multivariate study. These results suggest that although E-cadherin, CD44s, CD56, and nuclear gamma-catenin immuno-expression seem to be useful prognostic markers for serous neoplasm of the ovary, CD44s expression and FIGO stage are independent prognostic factors.
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Eun Yoon
authors.initials: EY
authors.lastname: Cho
authors.forename: Yoonla
authors.initials: Y
authors.lastname: Choi
authors.forename: Seoung Wan
authors.initials: SW
authors.lastname: Chae
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Sohn
authors.forename: Geung Hwan
authors.initials: GH
authors.lastname: Ahn
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D015820:Cadherins / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis*; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000737:chemistry* / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000473:pathology*; D011379:Prognosis; D016019:Survival Analysis; D051185:gamma Catenin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C473647:CD44S antigen; C112697:CD44v6 antigen; D019002:CD56 Antigen; C061828:CD99 protein, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D051185:gamma Catenin