Vinorelbine and venous irritation: optimal parenteral administration.
Vinorelbine is a vesicant associated with extra-vasation hazards and injection site reactions, which can be alleviated by shortening of infusion time and flushing of intravenous fluid. A critical review of the current evidence showed that the optimal administration is to flush >or= 75-124 mL of intravenous fluid after vinorelbine infusion. Intravenous push administration over 1-2 min does not seem to offer significant improvement over rapid intravenous infusion over 6-10 min.
de Lemos
Mário L
ML
Provincial Systemic Therapy Program, British Columbia Cancer Agency, Vancouver, BC V5Z 4E6, Canada. mdelemos@bccancer.bc.ca
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects* / Q000379:methods; D010689:Phlebitis / Q000139:chemically induced; D016032:Randomized Controlled Trials as Topic; D014680:Veins / Q000293:injuries; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine