title: Cutaneous leishmaniasis: three children with Leishmania major successfully treated with itraconazole.
abstract: We report the rare instance of four family members with numerous cutaneous lesions of Leishmania major contracted while on holiday in Algeria. Treatment was successful with oral itraconazole for the children and intralesional sodium stibogluconate for the mother. Cutaneous leishmaniasis should be considered in those with apparently sterile plaques returning from endemic areas. These results suggest that itraconazole, which is ideally suited for use in children, is an effective monotherapy for L. major.
authors.affiliation: Department of Dermatology, King's College Hospital, London, United Kingdom. Jonathan.White@kingsch.nhs.uk
authors.forename: J M L
authors.initials: JM
authors.lastname: White
authors.forename: J R
authors.initials: JR
authors.lastname: Salisbury
authors.forename: J
authors.initials: J
authors.lastname: Jones
authors.forename: E M
authors.initials: EM
authors.lastname: Higgins
authors.forename: F
authors.initials: F
authors.lastname: Vega-Lopez
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001707:Biopsy, Needle; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005190:Family; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D017964:Itraconazole / Q000627:therapeutic use*; D018320:Leishmania major / Q000187:drug effects* / Q000302:isolation & purification; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000469:parasitology*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole