Clinicopathologic findings and outcomes of liver transplantation using grafts from donors with unrecognized and unusual diseases.
Despite certain strict criteria for suitable organ donors, some unrecognized and unusual diseases have been transmitted through liver transplantation to recipients. In the current series, we review our experience with 14 patients who underwent liver transplantation using donor grafts with unusual pathology, including amyloidosis (6), schistosomiasis (3), iron overload (2), and alpha-1 antitrypsin deficiency (3). One of 6 patients who received grafts with amyloidosis developed vasculitis associated with the presence of arterial amyloid. With proper management, patients with donor schistosomiasis, iron overload and alpha-1 antitrypsin deficiency appear to have outcomes comparable to liver transplantation using grafts without these findings. In conclusion, long-term follow-up is necessary to confirm these findings and understand the impact of using these grafts.
Pungpapong
Surakit
S
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Krishna
Murli
M
Abraham
Susan C
SC
Keaveny
Andrew P
AP
Dickson
Rolland C
RC
Nakhleh
Raouf E
RE
D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000453:epidemiology / Q000473:pathology*; D000818:Animals; D001707:Biopsy, Needle; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D019190:Iron Overload / Q000453:epidemiology / Q000473:pathology*; D008099:Liver / Q000473:pathology* / Q000503:physiopathology; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012552:Schistosomiasis / Q000453:epidemiology / Q000473:pathology*; D012720:Severity of Illness Index; D014184:Transplantation, Homologous