Early patterns of verbal memory impairment in children treated for medulloblastoma.
Children treated for medulloblastoma demonstrate a variety of cognitive deficits in addition to white matter and hippocampal neuropathology. This study examined 40 children treated for medulloblastoma as compared with 40 demographically matched controls on the California Verbal Learning Test-Children's Version (D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1994). Results revealed significantly poorer performance on indices of word recall in the patient group as compared with the controls in addition to milder but still significantly poorer recognition memory. These findings suggest that children treated for medulloblastoma demonstrate a mixed profile of memory impairment consisting of both retrieval and recognition deficits. Implications of these findings for understanding neurobehavioral sequelae within pediatric medulloblastoma populations and for designing educational and remediation strategies to be used with these children are discussed.
Nagel
Bonnie J
BJ
Department of Psychiatry, University of California, San Diego, CA 92161, USA. bnagel@ucsd.edu
Delis
Dean C
DC
Palmer
Shawna L
SL
Reeves
Cara
C
Gajjar
Amar
A
Mulhern
Raymond K
RK
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000188:drug therapy* / Q000523:psychology / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000528:radiation effects*; D006801:Humans; D007223:Infant; D007360:Intelligence / Q000528:radiation effects; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000523:psychology / Q000532:radiotherapy*; D011939:Mental Recall / Q000528:radiation effects*; D020360:Neoadjuvant Therapy; D009483:Neuropsychological Tests; D011832:Radiation Injuries / Q000175:diagnosis* / Q000523:psychology; D012016:Reference Values; D019772:Topotecan / Q000008:administration & dosage*; D014706:Verbal Learning / Q000528:radiation effects*; D014825:Vocabulary; D014888:Wechsler Scales
D019772:Topotecan