title: Effects of the plant growth regulator, chlormequat, on mammalian fertility.
abstract: This paper summarizes the consequences of exposure to chlormequat, a plant growth regulator, on reproduction in mammals. Plant growth regulators are chemicals used to manipulate plant growth, flowering and fruit yield. In grain crops, plant growth regulators are applied to promote sturdier growth and reduce the risk of lodging. Chlormequat is the most common plant growth regulator. Maximum residue limits of chlormequat in food products are 10 mg/kg in oat and pear, 3 mg/kg in wheat and rye, and 0.5 mg/kg in milk. In Denmark, results from experiments with pigs in the late 1980s showed sows that display impaired reproduction, mainly impaired oestrus, when fed grain from crop treated with chlormequat. Subsequently, the advisory body to the Danish pig industry recommended limiting the use of grain (maximum 30% of diet energy) from crop treated with chlormequat given to breeding stock due to the risk of reproduction problems. More recently, experiments have been conducted to evaluate the influence of chlormequat-treated wheat crop on reproductive function in male and female mice. These experiments showed that epididymal spermatozoa from mice on feed or water containing chlormequat had compromised fertilizing competence in vitro, while reproduction in female mice was not compromised. The estimated intake of chlormequat in the pig (0.0023 mg/kg bw/day) and the mouse (0.024 mg/kg bw/day) experiments was below the acceptable daily intake of 0.05 mg/kg bw/day. Reports from the industry do not show any effects at these low levels.
authors.affiliation: Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, Denmark. martint.soresen@agrsci.dk
authors.forename: Martin T
authors.initials: MT
authors.lastname: Sørensen
authors.forename: Viggo
authors.initials: V
authors.lastname: Danielsen
mesh_terms: D000818:Animals; D002716:Chlormequat / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D051379:Mice; D010937:Plant Growth Regulators / Q000633:toxicity*; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*; D013552:Swine
chemical_list: D010937:Plant Growth Regulators; D002716:Chlormequat