Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?
Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.
Sahin
Mehmet
M
Department of Internal Medicine, Suleyman Demirel University, School of Medicine, Isparta, Turkey. mehmetsahin66@hotmail.com
Isler
Mehmet
M
Senol
Altug
A
Demirci
Mustafa
M
Aydin
Zeynep Dilek
ZD
D000208:Acute Disease; D005211:Fascioliasis / Q000821:virology*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018417:Th1 Cells / Q000276:immunology
D016898:Interferon-alpha