Solvent free microwave synthesis and evaluation of antimicrobial activity of pyrimido[4,5-b]- and pyrazolo[3,4-b]quinolines.
A series of 2-oxopyrimido[4,5-b]-, 2-thio[4,5-b]-, 1-(p-tosyl)pyrazolo[3,4-b]- and 1-(2',4'-dinitrophenyl)pyrazolo[3,4-b]-quinolines have been synthesized in good to excellent yields by environmentally benign solvent free microwave-induced techniques involving the condensation of 2-chloro-3-formylquinolines with urea, thiourea, p-toluenesulfonylhydrazide and 2,4-dinitrophenylhydrazine, respectively, using PTSA as a catalyst. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. Most of the compounds showed the best activity against Escherichia coli and Pseudomonas aeruginosa.
Selvi
Senniappan Thamarai
ST
Department of Chemistry (PG and Research), Kongunadu Arts and Science College, G.N. Mills Post, Coimbatore 641029, India. thamaraimohan@yahoo.co.in
Nadaraj
Vetrivel
V
Mohan
Sellappan
S
Sasi
Raju
R
Hema
Manoharan
M
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D002384:Catalysis; D004926:Escherichia coli / Q000187:drug effects; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D013237:Stereoisomerism
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011720:Pyrazoles; D011721:Pyrenes; D011743:Pyrimidines; D011804:Quinolines; C041343:1,3,6,8-pyrene tetrasulfonate