New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica.
A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
Staroverov
S M
SM
Chemical Department, Lomonosov State University, Leninskie Gory, 119992 Moscow, Russian Federation.
Kuznetsov
M A
MA
Nesterenko
P N
PN
Vasiarov
G G
GG
Katrukha
G S
GS
Fedorova
G B
GB
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006020:Glycopeptides / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C053759:eremomycin; D012822:Silicon Dioxide