[Comparison of effects of low-dose dopamine and dobutamine in patients with nonoliguric renal failure].
OBJECTIVE
To investigate the effects of low-dose dopamine and dobutamine on renal functioning patients with nonoliguric renal failure.


METHODS
Twenty-nine hemodynamically stable patients with nonoliguric renal failure were enrolled to this study group. Each patient was given 5% glucose (control), dopamine or dobutamine in random order by means of an injection pump every 4 hours. The change in urine output, fractional excretion of sodium (FeNa) and creatinine clearance rate (CCr) were determined.


RESULTS
Compared with control, urine volume, FeNa, and CCr were increased significantly after administration of dopamine, or dobutamine. Compared with dobutamine, dopamine could increase the urine output and the FeNa markedly, but there was no difference in CCr increase between dopamine and dobutamine.


CONCLUSIONS
Dopamine or dobutamine treatment could significantly increase the urine output, FeNa, and CCr in patients with nonoliguric renal failure. Dopamine infusion markedly increases urine output and the FeNa, but there is no significantly difference in CCr between dopamine and dobutamine treatment.
Li
Mao-qin
MQ
Department of Intensive Care Unit, Affiliated Hospital in Xuzhou of South-east University, Xuzhou 221009, Jiangsu, China.
Shi
Zai-xiang
ZX
Xu
Ji-yuan
JY
Zhang
Zhou
Z
Lu
Fei
F
Li
Lin
L
D000328:Adult; D000368:Aged; D004280:Dobutamine / Q000008:administration & dosage*; D004298:Dopamine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000503:physiopathology; D055815:Young Adult
D004280:Dobutamine; D004298:Dopamine