5,6:8,9-diepoxy and other cytotoxic sterols from the marine sponge Homaxinella sp.
Four new (1, 2, 4, and 5) and 14 known (3 and 6-18) polyoxygenated sterols have been isolated from the MeOH extract of the marine sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures of the sterols were established by 1D and 2D NMR and MS spectroscopic analysis. 5,6:8,9-Diepoxy sterols (1-3) were isolated from a marine organism for the first time. The isolated sterols were tested against a panel of five human solid tumor cell lines and exhibited varying degrees of cytotoxicity.
Mansoor
Tayyab A
TA
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Lee
Yoon Mi
YM
Hong
Jongki
J
Lee
Chong-O
CO
Im
Kwang Sik
KS
Jung
Jee H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013261:Sterols