title: An unusual oxalylated tetramic acid from the New Zealand basidiomycete Chamonixia pachydermis.
abstract: An unusual oxalylated tetramic acid, pachydermin (1), has been isolated from the New Zealand basidiomycete Chamonixiapachydermis. The full structure, which was not directly accessible by NMR methods, was deduced from that of a degradation product, 5-(3-chloro-4-hydroxybenzylidene)tetramic acid (2). The degradation product 2 exhibited mild antibacterial activity against Bacillus subtilis.
authors.affiliation: Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: Anthony L J
authors.initials: AL
authors.lastname: Cole
authors.forename: John W
authors.initials: JW
authors.lastname: Blunt
authors.forename: Murray H G
authors.initials: MH
authors.lastname: Munro
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects*; D001487:Basidiomycota / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; C508683:pachydermin; C009435:tetramic acid