[Effect of glucocorticoids on bone mineral density in patients with idiopathic thrombocytopenic purpura].
To elucidate the effects of glucocorticoid on bone mineral density in idiopathic thrombocytopenic purpura (ITP) patients, we retrospectively evaluated the relationship between bone mineral density (BMD) and the total dose of glucocorticoid or the mean daily dose given. We found decreased BMD in 66.7% of the patients with ITP to whom glucocorticoid was given, though rather normal bone BMD was observed in 28.6% of ITP patients treated without steroids. The mean level of BMD was markedly decreased in steroid-treated patients compared with steroid non-treated patients (p < 0.01). The relationship between BMD and the total dose of glucocorticoid (p = 0.023) or the mean daily dose revealed a negative correlation (p = 0.022). This study showed that glucocorticoid-induced osteoporosis was observed in patients with ITP, similar to other diseases already reported. When we think of this disease, many cases tend to be followed for a long time, and as the majority of ITP patients is female, we should pay particular attention in the prevention of glucocorticoid-induced osteoporosis.
Hasegawa
Minoru
M
Second Department of Internal Medicine, Osaka Medical College.
Nisikawa
Masakatsu
M
Nomura
Syosaku
S
Takubo
Takayuki
T
Suehiro
Akira
A
Saigo
Katsuyasu
K
Hayashi
Kunio
K
Tamaki
Shigehisa
S
Mizutani
Minoru
M
Uemura
Yasuhiro
Y
Kurata
Yosiyuki
Y
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004002:Clodronic Acid / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D012189:Retrospective Studies
D050071:Bone Density Conservation Agents; D005938:Glucocorticoids; D004002:Clodronic Acid; D011239:Prednisolone