[From the Cochrane Library: Improvement of photodamaged skin with retinoid creams and not with other local treatments].
A Cochrane systematic review of 30 randomised clinical trials assessed the effects of current treatments for adults with mild-to-severe changes in facial and forearm skin that occurred as a result of prolonged exposure to the sun ('photodamage'). Topical tretinoin > or = 0.02% improved the appearance of mild-to-severe photodamage. Tazarotene 0.01-0.1% and isotretinoin 0.1% provided benefit to patients with moderate photodamage. The treatment duration was 4-11 months. Adverse effects were pain and redness. Both the efficacy and adverse effects were dose-dependent. Other treatments, such as polysaccharides, hydroxy acids, surgical procedures and laser, cannot be recommended.
Hamerlynck
J V Th H
JV
Academisch Medisch Centrum/Universiteit van Amsterdam, Dutch Cochrane Centre, Amsterdam. j.v.hamerlynck@amc.uva.nl
Middeldorp
S
S
Scholten
R J P M
RJ
D000279:Administration, Cutaneous; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009539:Nicotinic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D015595:Skin Aging / Q000187:drug effects; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology; D013472:Sunlight / Q000009:adverse effects*; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*; D012176:Retinoids
D003879:Dermatologic Agents; D009539:Nicotinic Acids; D014212:Tretinoin; C086827:tazarotene; D012176:Retinoids