Antibacterial compounds from Glycyrrhiza uralensis.
From the roots of Glycyrrhiza uralensis, two new pterocarpenes, glycyrrhizol A (1) and glycyrrhizol B (2), along with four known isoflavonoids, 5-O-methylglycryol (3), isoglycyrol (4), 6,8-diisoprenyl-5,7,4'-trihydroxyisoflavone (5), and gancaonin G (6), were isolated using a bioassay-guided fractionation method. The structures of the new compounds (1and 2) were elucidated by spectroscopic data interpretation. The known compounds (3-6) were identified by comparison of their spectroscopic data with reported values in the literature. Glycyrrhizol A (1) and 6,8-diisoprenyl-5,7,4'-trihydroxyisoflavone (5) exhibited potent antibacterial activity against Streptococcus mutans with minimum inhibitory concentrations of 1 and 2 microg/mL, respectively, while glycyrrhizol B (2) and gancaonin G (6) showed more moderate activity.
He
Jian
J
School of Dentistry and Dental Research Institute, University of California, Los Angeles, California 90095, USA.
Chen
Li
L
Heber
David
D
Shi
Wenyuan
W
Lu
Qing-Yi
QY
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D036343:Pterocarpans; C508542:glycyrrhizol A; C508543:glycyrrhizol B