title: Plasma leptin and ghrelin concentrations in patients with Crohn's disease.
abstract: OBJECTIVE
  To determine the concentrations of leptin and ghrelin, which have opposite effects on appetite, energy expenditure, and weight control, in the plasma of patients with Crohn's disease (CD), which is often associated with weight loss and malnutrition.
  
  
  METHODS
  Plasma leptin and ghrelin 'concentrations were determined in 28 outpatients with CD by radioimmunoassay. Age- and sex-matched controls with and without Helicobacter pylori (H pylori) infection (28 for each) were enrolled in the study. Circulating levels of these hormones were assessed with respect to CD activity, disease localization and medical treatment.
  
  
  RESULTS
  There were no significant differences in ghrelin levels between CD patients and H pylori-negative controls. However, circulating ghrelin levels were significantly lower in H pylori-infected subjects than in CD patients and uninfected controls. Plasma leptin levels were comparable among the groups. Localization and medication profile had no significant impact on circulating ghrelin and leptin levels.
  
  
  CONCLUSIONS
  Apart from H pylori infection, CD itself has no significant influence on circulating ghrelin and leptin levels in the outpatients who were mostly in inactive state.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Nishi
authors.forename: Hajime
authors.initials: H
authors.lastname: Isomoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ueno
authors.forename: Ken
authors.initials: K
authors.lastname: Ohnita
authors.forename: Chun Yang
authors.initials: CY
authors.lastname: Wen
authors.forename: Fuminao
authors.initials: F
authors.lastname: Takeshima
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Mishima
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Nakazato
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003424:Crohn Disease / Q000097:blood* / Q000150:complications; D005260:Female; D054439:Ghrelin; D016481:Helicobacter Infections / Q000097:blood; D016480:Helicobacter pylori; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D044342:Malnutrition / Q000209:etiology; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D015431:Weight Loss
chemical_list: D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones