Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors.
A new type of noncompetitive alpha-2,3-sialyltransferase inhibitor has been synthesized; we report the discovery, preparation and inhibitory activity of sixteen lithocholic acid analogues.
Chang
Kai-Hsuan
KH
Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Lee
Lenselot
L
Chen
Jessica
J
Li
Wen-Shan
WS
D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008095:Lithocholic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D008956:Models, Chemical; D012794:Sialic Acids / Q000737:chemistry; D012799:Sialyltransferases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D012794:Sialic Acids; D008095:Lithocholic Acid; D012799:Sialyltransferases; C029156:N-acetyllactosaminide alpha-2,3-sialyltransferase