Regulation of mucin genes in chronic inflammatory airway diseases.
In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.
Voynow
Judith A
JA
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. voyno001@mc.duke.edu
Gendler
Sandra J
SJ
Rose
Mary C
MC
D000818:Animals; D001249:Asthma / Q000235:genetics / Q000378:metabolism; D003550:Cystic Fibrosis / Q000235:genetics / Q000378:metabolism; D016207:Cytokines; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D008070:Lipopolysaccharides; D008168:Lung / Q000378:metabolism*; D055271:Mucin 5AC; D055262:Mucin-2; D009077:Mucins / Q000235:genetics* / Q000378:metabolism*; D009093:Mucus / Q000378:metabolism; D011014:Pneumonia / Q000235:genetics* / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D016207:Cytokines; D008070:Lipopolysaccharides; C524625:MUC2 protein, human; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D055262:Mucin-2; D009077:Mucins