A case of peritonitis caused by Rhizopus microsporus.
We report a case of a 62-year-old female patient who developed peritonitis after receiving a renal transplant. Candida glabrata was detected and treated with voriconazole. As the patient did not improve under therapy, laparotomy was performed. Mould-like plaques were found on the peritoneum. Using culture as well as pan-fungal polymerase chain reaction (PCR) followed by DNA microarray hybridisation of the amplicon, the causative agent was identified as Rhizopus microsporus. Despite aggressive surgical treatment, intravenous therapy with amphotericin B and topical administration of Lavasept (polyhexamethylenbiguanide), the patient died.
Monecke
Stefan
S
Hochauf
Kristina
K
Gottschlich
Birgit
B
Ehricht
Ralf
R
D000666:Amphotericin B / Q000008:administration & dosage; D001645:Biguanides / Q000008:administration & dosage; D041221:Candida glabrata / Q000302:isolation & purification; D004271:DNA, Fungal / Q000032:analysis / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D010535:Laparoscopy; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D010538:Peritonitis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D016133:Polymerase Chain Reaction; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012233:Rhizopus / Q000235:genetics / Q000302:isolation & purification*
D001645:Biguanides; D004271:DNA, Fungal; D000666:Amphotericin B