Brain injury from cardiac arrest in children.
This article reviews the important differences between children and adults suffering brain injury following cardiac arrest. The differences in etiology, pathophysiology, neuronal vulnerability, and repair in the context of the developing brain are reviewed. The available clinical data are reviewed, and selected treatment priori-ties are declared. The article includes a discussion of knowledge gaps and future directions.
Hickey
Robert W
RW
Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Pittsburgh, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA. robert.hickey@chp.edu
Painter
Michael J
MJ
D001237:Asphyxia / Q000150:complications; D001921:Brain / Q000098:blood supply / Q000473:pathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D002648:Child; D006323:Heart Arrest / Q000453:epidemiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011379:Prognosis