Expression of Notch1 and Math1 in mandibular condyle cartilage in neonatal mice.
On the basis of the cellular morphological changes in the cartilaginous area, the mandibular condylar cartilage is histopathologically composed of four different cell layers--fibrous, proliferative, maturative, and hypertrophic. Reaction for Notch1 was present in the hypertrophic cells only. However, Math1 was locally distributed in the hypertrophic layer and partially in the proliferative layer. The expression patterns of Notch1 and Math1 were slightly different. These results suggest that the morphogenesis regulation factors of Notch1 and Math1 may play some role in mandibular condylar cartilage. Positive reactions to osteopontin, as a control, were detected in the cytoplasm of all layers, although they varied from published data.
Shimizu
Takako
T
Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan. stg0317@po.mdu.ac.jp
Tsujigiwa
Hidetsugu
H
Nagatsuka
Hitoshi
H
Okafuji
Norimasa
N
Kurihara
Saburo
S
Nagai
Noriyuki
N
Kawakami
Toshiyuki
T
D000818:Animals; D000831:Animals, Newborn; D051792:Basic Helix-Loop-Helix Proteins / Q000032:analysis*; D002356:Cartilage / Q000033:anatomy & histology* / Q000254:growth & development; D049109:Cell Proliferation; D003593:Cytoplasm / Q000648:ultrastructure; D006984:Hypertrophy; D007150:Immunohistochemistry; D008335:Mandibular Condyle / Q000033:anatomy & histology* / Q000254:growth & development; D051379:Mice; D009024:Morphogenesis / Q000502:physiology; D053495:Osteopontin; D010750:Phosphoproteins / Q000032:analysis; D051881:Receptor, Notch1 / Q000032:analysis*; D012795:Sialoglycoproteins / Q000032:analysis
D051792:Basic Helix-Loop-Helix Proteins; D053495:Osteopontin; D010750:Phosphoproteins; D051881:Receptor, Notch1; D012795:Sialoglycoproteins; C500943:Atoh1 protein, mouse; C497762:Notch1 protein, mouse; C506896:Spp1 protein, mouse