Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.
Oral prostaglandin E2 protected the gastric mucosa against the damage induced by intraperitoneal indomethacin in the rat. Blocking of the gastric alkaline secretion by subcutaneous acetazolamide potentiated the ulcerogenic action of indomethacin and reduced or abolished the protective effect of a submaximal dose prostaglandin E2. The results are compatible with the hypothesis that stimulation of the alkaline secretion is one of the mechanisms by which prostaglandin E2 protects the gastric mucosa.
Kollberg
B
B
G-I Unit, Dept. of Medicine, Karolinska Hospital, Stockholm, Sweden.
Aly
A
A
Rubio
C
C
Johansson
C
C
D000086:Acetazolamide / Q000008:administration & dosage / Q000633:toxicity*; D000468:Alkalies / Q000378:metabolism; D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000633:toxicity*; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000633:toxicity; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007213:Indomethacin / Q000008:administration & dosage / Q000819:agonists / Q000633:toxicity; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000468:Alkalies; D002257:Carbonic Anhydrase Inhibitors; D016861:Cyclooxygenase Inhibitors; D015232:Dinoprostone; D000086:Acetazolamide; D007213:Indomethacin