title: Lead blood concentrations and renal function evaluation: study in an exposed Mexican population.
abstract: The relation of blood Pb concentrations and renal dysfunction has been reported in association with interstitial fibrosis, tubular atrophy, and decreased glomerular filtration. In this report information about blood Pb concentrations and renal function tests in a population from Oaxaca, Mexico is analyzed. The main changes found were that males had higher blood Pb concentrations than females (P<0.0012); the leading variables associated with this were occupation (glazed pottery workers, P=0.0001) and the use of glazed pottery for preparing meals (P=0.0000). Variables that better explain uric acid variability were blood Pb concentrations, sex, weight, and height (r2=0.23). Hyperuricemia was associated with blood Pb concentrations above 40 microg/dL (OR=1.74, 95% CI, 1.12-2.61). SCr was associated with sex, age, and blood Pb, with coefficient r2=0.12. Our findings might be related to inadequate control of oven emissions, a situation that will require further analysis and the implementation of preventive measurements for the nonoccupational exposed population.
authors.affiliation: Instituto Nacional de Salud Pública, Cuernavaca, México.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Hernández-Serrato
authors.forename: Teresa Imelda
authors.initials: TI
authors.lastname: Fortoul
authors.forename: Rosalba
authors.initials: R
authors.lastname: Rojas-Martínez
authors.forename: Laura R
authors.initials: LR
authors.lastname: Mendoza-Alvarado
authors.forename: Lourdes
authors.initials: L
authors.lastname: Canales-Treviño
authors.forename: Tommaso
authors.initials: T
authors.lastname: Bochichio-Riccardelli
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Avila-Costa
authors.forename: Gustavo
authors.initials: G
authors.lastname: Olaiz-Fernández
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D003297:Cooking and Eating Utensils; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced*; D007677:Kidney Function Tests; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008800:Mexico; D012709:Serum Albumin / Q000378:metabolism; D011795:Surveys and Questionnaires; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D014527:Uric Acid; D007854:Lead; D014508:Urea; D003404:Creatinine