title: Hereditary spastic paraplegia associated with dopa-responsive parkinsonism.
abstract: A 47-year-old patient with hereditary spastic paraplegia and parkinsonian features is reported. Treatment with levodopa led to marked improvement in his neurological status and quality of life. However, several years later he developed motor fluctuations and dyskinesias. The latter promptly remitted with amantadine treatment.
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina. fmicheli@fibertel.com.ar
authors.forename: Federico
authors.initials: F
authors.lastname: Micheli
authors.forename: María Graciela
authors.initials: MG
authors.lastname: Cersósimo
authors.forename: Carlos
authors.initials: C
authors.lastname: Zúñiga Ramírez
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000209:etiology*; D015419:Spastic Paraplegia, Hereditary / Q000150:complications* / Q000188:drug therapy
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa