[Successful treatment with CHOP therapy for progressive of primary macroglobulinemia without further increase of serum IgM].
A 61-year-old man with primary macroglobulinemia (PMG) had been followed without any treatment as he had no apparent manifestations. After 1 year and 3 months, he was admitted to our hospital with a fever. No signs or symptoms of infection and no progressive increase of serum IgM levels was observed. Non-Hodgkin's lymphoma was not additionally found. Fever without infection, elevated serum LDH level and further enlargement of the spleen compelled us to diagnose his condition as deterioration of the PMG. An immediate fall in his temperature and serum IgM levels was observed after CHOP therapy. Effective therapy must be discussed in the deterioration of this type of disease.
Wakimoto
Naoki
N
Department of Internal Medicine, Division of Hematology, Saitama Medical School.
Misumi
Motohiro
M
Maeda
Tomoya
T
Shimada
Tsuneyuki
T
Wakao
Daisuke
D
Sato
Yasutaka
Y
Takahashi
Naoki
N
Sugahara
Yuichi
Y
Yoshida
Katsuhiko
K
Yagasaki
Fumiharu
F
Ito
Yoshihiro
Y
Nakamura
Yuichi
Y
Kawai
Nobutaka
N
Matsuda
Akira
A
Jinnai
Itsuro
I
Bessho
Masami
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis / Q000188:drug therapy*
D015415:Biomarkers; D007075:Immunoglobulin M; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone