Rosai-Dorfman disease: two case reports and diagnostic role of fine-needle aspiration cytology.
Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare and self-limiting benign disorder that most commonly involves the cervical lymph nodes. The authors describe two cases of SHML. Fine-needle aspiration of the lymphadenopathy was performed in both patients. Immunocytochemical and histologic features, as the evidence of emperipolesis and S100 protein positivity on immunostaining, were typical of SHML. Fine-needle aspiration cytology plays an important diagnostic role in SHML and may be conclusive in a typical clinical setting. The diagnosis of SHML should be considered in the differential diagnosis of massive, painless cervical lymphadenopathy. Long-term follow-up is necessary to observe the complete regression of the massive lymphadenopathy. However, specific therapy is available and should be limited to patients with compressive symptoms or extranodal disease.
Ruggiero
Antonio
A
Division of Pediatric Oncology, Catholic University, Rome, Italy. riccardi@rm.unicatt.it
Attinà
Giorgio
G
Maurizi
Palma
P
Mulè
Antonino
A
Tarquini
Elisabetta
E
Barone
Giuseppe
G
Lazzareschi
Ilaria
I
Riccardi
Riccardo
R
D044963:Biopsy, Fine-Needle; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D009333:Neck; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography