title: Locally weighted transmission/disequilibrium test for genetic association analysis.
abstract: The transmission/disequilibrium test statistic has been used for assessing genetic association in affected-parent trios. In the presence of multiple tightly linked marker loci where local dependency may exist, haplotypes are reconstructed statistically to estimate the joint effects of these markers. In this manuscript, we propose an alternative to the haplotype approach by taking a weighted average of multiple loci, where the weight is proportional to the product of (1-2X recombination fraction) and the linkage disequilibrium between markers. As an illustration, we applied the method to the simulated Aipotu data.
authors.affiliation: Modeling and Methods, Biostatistics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA. lih@fhcrc.org
authors.forename: Li
authors.initials: L
authors.lastname: Hsu
authors.forename: Xuesong
authors.initials: X
authors.lastname: Yu
authors.forename: Jeanine J
authors.initials: JJ
authors.lastname: Houwing-Duistermaat
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Uh
authors.forename: Rachid
authors.initials: R
authors.lastname: El Galta
authors.forename: Jeremie J P
authors.initials: JJ
authors.lastname: Lebrec
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
mesh_terms: D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics