title: Fluoxetine reverses stress-induced fimbria-prefrontal long-term potentiation facilitation.
abstract: Stress has been reported to disrupt the induction of synaptic plasticity in different fimbria target structures. The aim of the present study was to investigate whether chronic mild stress may also affect synaptic plasticity in the medial prefrontal cortex, a fimbria target structure. Fimbria tetanus (100 Hz) did not produce any changes in medial prefrontal cortex synaptic efficacy in non-stressed rats. Rats exposed to chronic mild stress, however, developed significant long-term potentiation. Treatment with fluoxetine (10 mg/kg, intraperitoneal) suppressed long-term potentiation induction in the chronic mild stress group. These data demonstrate that stress not only inhibits long-term potentiation development, as often demonstrated, but can also facilitate long-term potentiation development in certain brain circuits.
authors.affiliation: Laboratoire de Neurobiologie et Psychopathologie, Institut National de la Santé et de la Recherche Médicale, Equipe Avenir, Université de Nice-Sophia Antipolis, Nice, France.
authors.forename: Karima
authors.initials: K
authors.lastname: Kessal
authors.forename: Olivier
authors.initials: O
authors.lastname: Deschaux
authors.forename: Aline
authors.initials: A
authors.lastname: Chessel
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Moreau
authors.forename: René
authors.initials: R
authors.lastname: Garcia
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D005473:Fluoxetine / Q000494:pharmacology*; D020712:Fornix, Brain / Q000187:drug effects / Q000503:physiopathology / Q000528:radiation effects; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000473:pathology*; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013312:Stress, Physiological / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors