Evaluation of anti-inflammatory and antioxidant activities of mixed-ligand Cu(II) complexes of dien and its Schiff dibases with heterocyclic aldehydes and 2-amino-2-thiazoline.
A new series of complexes of the type [Cu(dien)(2a-2tzn)Y2] and [Cu(dienXX)(2a-2tzn)Y2] has been tested for anti-inflammatory and antioxidant activity. The tested compounds inhibit significantly the carrageenin induced paw edema (36.4-55.8%) and present important scavenging activities. Although their interaction with the free stable radical DPPH is not high they peroxide anions. Compound 7 is the most potent (55.8%) in the in vivo experiment. Lipophilicity--as RM values and theoretically calculated logP values--has been determined. An attempt to correlate the biological results with their structural characteristics and physicochemical parameters has been done.
Pontiki
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Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Hadjipavlou-Litina
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Chaviara
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AT
Bolos
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CA
D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D002413:Cations, Divalent; D003300:Copper / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000378:metabolism; D016166:Free Radical Scavengers; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012545:Schiff Bases / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry*
D000447:Aldehydes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D002413:Cations, Divalent; D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D012545:Schiff Bases; D013844:Thiazoles; C031363:2-aminothiazoline; D003300:Copper; D002351:Carrageenan