Large-scale sequence analysis of avian influenza isolates.
The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.
Obenauer
John C
JC
Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Denson
Jackie
J
Mehta
Perdeep K
PK
Su
Xiaoping
X
Mukatira
Suraj
S
Finkelstein
David B
DB
Xu
Xiequn
X
Wang
Jinhua
J
Ma
Jing
J
Fan
Yiping
Y
Rakestraw
Karen M
KM
Webster
Robert G
RG
Hoffmann
Erich
E
Krauss
Scott
S
Zheng
Jie
J
Zhang
Ziwei
Z
Naeve
Clayton W
CW
D000818:Animals; D001717:Birds / Q000821:virology; D019295:Computational Biology; D005814:Genes, Viral; D016679:Genome, Viral; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics; D053121:Influenza A Virus, H2N2 Subtype / Q000235:genetics; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics; D053123:Influenza A Virus, H3N8 Subtype / Q000235:genetics; D053124:Influenza A Virus, H5N1 Subtype / Q000737:chemistry / Q000235:genetics* / Q000472:pathogenicity; D053125:Influenza A Virus, H5N2 Subtype / Q000235:genetics; D053126:Influenza A Virus, H7N7 Subtype / Q000235:genetics; D053127:Influenza A Virus, H9N2 Subtype / Q000235:genetics; D009980:Influenza A virus / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D005585:Influenza in Birds / Q000821:virology; D007251:Influenza, Human / Q000821:virology; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics; D017422:Sequence Analysis, DNA; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000235:genetics; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics; D037521:Virulence Factors / Q000737:chemistry* / Q000235:genetics
C085820:INS1 protein, influenza virus; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; D037521:Virulence Factors