title: [Integrated treatment of peritoneal carcinomatosis: preliminary experience].
abstract: A prospective study has been carried on 37 patients, 35 of them affected by peritoneal carcinomatosis from ovarian (16), appendiceal (7), colorectal (5), mesothelial (4), gastric (3) primary and 2 affected by sarcomatosis. Mean PCI was 22 (median, 22). Eighty-five percent of the patients presented debilitating ascites associated in 23% to initial symptoms of intestinal obstruction. All the patients have been treated with peritonectomy and intraoperative hyperthermic chemoperfusion and CC 0-1 cytoreduction was achieved in 81%. Major morbidity and mortality was respectively 37.8% and 16.2%, where 5 out 6 deaths recorded in the first 19 months of our experience, representing our learning curve. At a median follow-up of 8 months (range, 1-54), 18 patients are alive and disease-free and 4 patients are alive with disease. Two-yr overall survival was 49.1% for all series. Difference in survival evaluating CC 0-1 vs CC 2 patients was statistically significant.
authors.affiliation: Azienda Ospedaliera San Camillo Forlanini, UOC di Chirurgia Generale Oncologica, Roma.
authors.forename: B
authors.initials: B
authors.lastname: De Rosa
authors.forename: M
authors.initials: M
authors.lastname: Valle
authors.forename: F
authors.initials: F
authors.lastname: Cavaliere
authors.forename: O
authors.initials: O
authors.lastname: Federici
authors.forename: I
authors.initials: I
authors.lastname: Sperduti
authors.forename: A
authors.initials: A
authors.lastname: Garofalo
mesh_terms: D002277:Carcinoma / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D010534:Peritoneal Neoplasms / Q000628:therapy*; D011446:Prospective Studies