Rotaxanes of cyclic peptides.
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Aucagne
Vincent
V
University of Edinburgh, School of Chemistry, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.
Leigh
David A
DA
Lock
Julia S
JS
Thomson
Andrew R
AR
D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D043862:Rotaxanes / Q000138:chemical synthesis* / Q000737:chemistry
D010456:Peptides, Cyclic; D043862:Rotaxanes; C062238:cyclo(prolylglycyl)