title: Oral histoplasmosis in an HIV-negative patient.
abstract: Histoplasmosis is a deep mycosis caused by Histoplasma capsulatum, which has been found in soil with accumulated excreta of bats and birds. This disease has variable clinical findings with only pulmonary or systemic involvement. Upper aerodigestive lesions are found mainly associated with systemic disease, affecting particularly patients with immunosuppression conditions mainly caused by HIV. However, it is uncommon in immunocompetent patients. This report describes a case of oro-laryngeal-esophageal histoplasmosis in a HIV-seronegative patient without detectable systemic involvement.
authors.affiliation: Department of Oral Diagnosis, Dental School, University of Campinas (UNICAMP), Piracicaba, Sao Paulo, Brazil.
authors.forename: Mônica Leal
authors.initials: ML
authors.lastname: Alcure
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Di Hipólito Júnior
authors.forename: Oslei Paes de
authors.initials: OP
authors.lastname: Almeida
authors.forename: Hamilton
authors.initials: H
authors.lastname: Bonilha
authors.forename: Márcio Ajudarte
authors.initials: MA
authors.lastname: Lopes
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D004935:Esophageal Diseases / Q000188:drug therapy / Q000473:pathology; D018023:HIV Seronegativity; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D009960:Oropharynx / Q000473:pathology; D010608:Pharyngeal Diseases / Q000188:drug therapy / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole