title: Five new diels-alder type adducts from the stem and root bark of Morus mongolica.
abstract: Five new Diels-Alder type adducts, mongolicins A - E, and nine known compounds, mongolicin F, chalcomoracin, mulberrofuran T, mulberrofuran G, mulberrofuran F, albanol B, kuwanon O, mulberrofuran H and kuwanon H, were isolated from the stem and root bark of Morus mongolica. Their structures were determined by spectroscopic analysis and chiroptical methods. Among them, compounds and showed potent anti-inflammatory activities (inhibition of release of beta-glucuronidase from rat PMNs induced by PAF) with inhibitory ratios of 80.4% (P<0.05) and 77.0% (P<0.001) at a concentration of 10(-5) mol L-1. Compounds and were active as antioxidatives (inhibition of liver microsomal lipid peroxidation induced by Fe2+-Cys system) with inhibitory ratios of 83.6% (P<0.05), 86.0% (P<0.05), and 63.0% (P<0.05) at a concentration of 10(-5) mol L-1.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Kang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification; D000975:Antioxidants / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants