Screening and synthesis: high throughput technologies applied to parasitology.
High throughput technologies continue to develop in response to the challenges set by the genome projects. This article discusses how the techniques of both high throughput screening (HTS) and synthesis can influence research in parasitology. Examples of the use of targeted and phenotype-based HTS using unbiased compound collections are provided. The important issue of identifying the protein target(s) of bioactive compounds is discussed from the synthetic chemist's perspective. This article concludes by reviewing recent examples of successful target identification studies in parasitology.
Morgan
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School of Chemistry, Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
Westwood
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NJ
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D010274:Parasitology / Q000379:methods*; D040901:Proteomics / Q000379:methods*; D015800:Protozoan Proteins / Q000032:analysis*
D015800:Protozoan Proteins