title: Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists.
abstract: The identification and optimization of a series of acylguanidine-based melanocortin-4 receptor antagonists is discussed.
authors.affiliation: Millennium Pharmaceuticals, Inc. 40 Landsdowne St. Cambridge, MA 02139, USA. tricia.vos@mpi.com
authors.forename: Tricia J
authors.initials: TJ
authors.lastname: Vos
authors.forename: Suresh
authors.initials: S
authors.lastname: Balani
authors.forename: Christopher
authors.initials: C
authors.lastname: Blackburn
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Chau
authors.forename: M Diana
authors.initials: MD
authors.lastname: Danca
authors.forename: Stacey V
authors.initials: SV
authors.lastname: Drabic
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Farrer
authors.forename: Michael A
authors.initials: MA
authors.lastname: Patane
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Stroud
authors.forename: David L
authors.initials: DL
authors.lastname: Yowe
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Claiborne
mesh_terms: D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D019791:Guanidine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D051379:Mice; D010949:Plasma / Q000378:metabolism; D044105:Receptor, Melanocortin, Type 4 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D044105:Receptor, Melanocortin, Type 4; D013438:Sulfhydryl Compounds; D019791:Guanidine