title: [HIV infection presenting with bilateral optic neuropathy].
abstract: We report the case of a 57-year-old man who presented bilateral subacute and painless optic neuropathy after meningopolyradiculitis revealing a primary human immunodeficiency virus infection. Both antiretroviral and steroid treatments were ineffective. Clinical symptoms and evolutive pattern were consistent with a mechanism of microvascular ischaemia of the optic nerve head. Optic neuropathies related to HIV infection are rare compared to those resulting from opportunistic infections. There are several pathophysiological mechanisms involved.
authors.affiliation: Unité de Neuro-Ophtalmologie, Hôpital Neurologique et Université Claude Bernard Lyon I.
authors.forename: C
authors.initials: C
authors.lastname: Laurent-Coriat
authors.forename: C
authors.initials: C
authors.lastname: Tilikete
authors.forename: D
authors.initials: D
authors.lastname: Bouhour
authors.forename: J
authors.initials: J
authors.lastname: Boulliat
authors.forename: J
authors.initials: J
authors.lastname: Fleury
authors.forename: M
authors.initials: M
authors.lastname: Bernard
authors.forename: A
authors.initials: A
authors.lastname: Vighetto
mesh_terms: D015492:AIDS Serodiagnosis; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005074:Evoked Potentials, Visual; D005155:Facial Nerve Diseases / Q000209:etiology; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D007511:Ischemia / Q000209:etiology; D019259:Lamivudine / Q000627:therapeutic use; D061466:Lopinavir; D008297:Male; D008587:Meningitis, Viral / Q000209:etiology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009898:Optic Disk / Q000098:blood supply; D009901:Optic Nerve Diseases / Q000188:drug therapy / Q000209:etiology*; D011128:Polyradiculopathy / Q000209:etiology; D011744:Pyrimidinones / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D019438:Ritonavir / Q000627:therapeutic use; D014794:Visual Fields; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D018894:Reverse Transcriptase Inhibitors; D061466:Lopinavir; D019259:Lamivudine; D015215:Zidovudine; D019438:Ritonavir; D008775:Methylprednisolone