Bicyclic carbohydrate-derived scaffolds for combinatorial libraries.
A bicyclic scaffold derived from the natural monosaccharide d-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-3' position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.
Cervi
Giovanni
G
Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza 2, I-20126 Milano, Italy.
Peri
Francesco
F
Battistini
Carlo
C
Gennari
Cesare
C
Nicotra
Francesco
F
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D004354:Drug Screening Assays, Antitumor; D005947:Glucose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011714:Pyrans / Q000737:chemistry
D000970:Antineoplastic Agents; D001643:Bridged Bicyclo Compounds; D011714:Pyrans; D005947:Glucose