title: Emergence of Enterobacteriaceae isolates producing CTX-M extended-spectrum beta-lactamase in Austria.
abstract: Among 149 extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae isolates collected from patients in southeast Austria from 1998 to 2004, 38 Escherichia coli isolates and 11 Klebsiella spp. were CTX-M producers. The proportion of CTX-M-producers among all ESBL producers rose from 0% in 1998 to 58% in 2004. In general, CTX-M-producers had heterogeneous pulsed-field gel electrophoresis patterns, but one E. coli isolate was identical to a United Kingdom epidemic CTX-M-15-producing strain, although no epidemiological link with the United Kingdom was apparent.
authors.affiliation: Institute of Hygiene, Medical University of Graz, Universitätsplatz 4, A-8010 Graz, Austria. alexandra.eisner@meduni-graz.at
authors.forename: Alexandra
authors.initials: A
authors.lastname: Eisner
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Fagan
authors.forename: Gebhard
authors.initials: G
authors.lastname: Feierl
authors.forename: Harald H
authors.initials: HH
authors.lastname: Kessler
authors.forename: Egon
authors.initials: E
authors.lastname: Marth
authors.forename: David M
authors.initials: DM
authors.lastname: Livermore
authors.forename: Neil
authors.initials: N
authors.lastname: Woodford
mesh_terms: D016521:Electrophoresis, Gel, Pulsed-Field; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000096:biosynthesis; D006801:Humans; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D029968:Escherichia coli Proteins; C412613:CTX-M-9 protein, E coli; C071167:beta-lactamase CTX-2; C473109:beta-lactamase CTX-M-15; C055184:beta-lactamase TEM-3; D001618:beta-Lactamases