Serum lipid and lipoprotein alterations represent recovery of liver function after hepatectomy.
BACKGROUND
The assessment of liver function during human liver regeneration is necessary to prevent unexpected liver failure and to prepare for further treatment. We selected patients prospectively and measured serum lipid and lipoprotein levels to identify which lipids and lipoproteins could represent recovery of liver function in human liver regeneration.


METHODS
Thirty selected patients who underwent hepatectomy were divided into three groups depending on the serum hyaluronate (HA) level and the type of liver resection.


RESULTS
We found three patterns of lipid and lipoprotein alterations after hepatectomy. Among the lipids and lipoproteins examined, the serum beta-lipoprotein and low-density lipoprotein (LDL) levels were significantly different among the groups at 7 days after hepatectomy. The alteration of the apolipoprotein (Apo) B level was similar to that of LDL. The LDL level was correlated with both beta-lipoprotein and Apo B before hepatectomy (r=0.653 and 0.894, respectively) and at 7 days after hepatectomy (r=0.841 and 0.943, respectively).


CONCLUSIONS
Serum HA before hepatectomy can reflect postoperative liver function depending on the type of liver resection. Recovery of the beta-lipoprotein and LDL levels can reflect the recovery of liver function in human liver regeneration within the early period in association with the Apo B level.
Kawamoto
Masaki
M
Department of Surgery I, Sapporo Medical University Hospital, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Mizuguchi
Toru
T
Nagayama
Minoru
M
Nobuoka
Takayuki
T
Kawasaki
Hiroyuki
H
Sato
Taishi
T
Koito
Kazumitsu
K
Parker
Susan
S
Katsuramaki
Tadashi
T
Hirata
Koichi
K
D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D006498:Hepatectomy; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008111:Liver Function Tests; D008115:Liver Regeneration / Q000502:physiology*; D008875:Middle Aged; D020127:Recovery of Function / Q000502:physiology*
D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D006820:Hyaluronic Acid