Sarcoidosis in chronic granulomatous disease.
In addition to increased susceptibility to infections in patients with chronic granulomatous disease (CGD), a higher incidence of sterile inflammatory disorders in these patients has been noted. However, sarcoidosis has not been reported previously in CGD. In this report, we describe two patients who have CGD and a disorder consistent with sarcoidosis on the basis of unequivocal clinical-radiographic presentations, their responses to treatment, and serum angiotensin-converting enzyme levels. Serum angiotensin-converting enzyme levels were measured in 26 other patients with CGD to establish an appropriate reference range. A possible relationship between CGD and sarcoidosis is discussed.
De Ravin
Suk See
SS
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Naumann
Nora
N
Robinson
Michael R
MR
Barron
Karyl S
KS
Kleiner
David E
DE
Ulrick
Jean
J
Friend
Julia
J
Anderson
Victoria L
VL
Darnell
Dirk
D
Kang
Elizabeth M
EM
Malech
Harry L
HL
D000293:Adolescent; D002493:Central Nervous System Diseases / Q000150:complications / Q000175:diagnosis; D002648:Child; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis; D017565:Sarcoidosis, Pulmonary / Q000150:complications / Q000175:diagnosis