title: [Comparison of effects of low-dose dopamine and dobutamine in patients with nonoliguric renal failure].
abstract: OBJECTIVE
  To investigate the effects of low-dose dopamine and dobutamine on renal functioning patients with nonoliguric renal failure.
  
  
  METHODS
  Twenty-nine hemodynamically stable patients with nonoliguric renal failure were enrolled to this study group. Each patient was given 5% glucose (control), dopamine or dobutamine in random order by means of an injection pump every 4 hours. The change in urine output, fractional excretion of sodium (FeNa) and creatinine clearance rate (CCr) were determined.
  
  
  RESULTS
  Compared with control, urine volume, FeNa, and CCr were increased significantly after administration of dopamine, or dobutamine. Compared with dobutamine, dopamine could increase the urine output and the FeNa markedly, but there was no difference in CCr increase between dopamine and dobutamine.
  
  
  CONCLUSIONS
  Dopamine or dobutamine treatment could significantly increase the urine output, FeNa, and CCr in patients with nonoliguric renal failure. Dopamine infusion markedly increases urine output and the FeNa, but there is no significantly difference in CCr between dopamine and dobutamine treatment.
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital in Xuzhou of South-east University, Xuzhou 221009, Jiangsu, China.
authors.forename: Mao-qin
authors.initials: MQ
authors.lastname: Li
authors.forename: Zai-xiang
authors.initials: ZX
authors.lastname: Shi
authors.forename: Ji-yuan
authors.initials: JY
authors.lastname: Xu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Lu
authors.forename: Lin
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D004280:Dobutamine / Q000008:administration & dosage*; D004298:Dopamine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D004280:Dobutamine; D004298:Dopamine