[Study on the relationship between polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia].
OBJECTIVE
To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia.


METHODS
ApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing.


RESULTS
A total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05).


CONCLUSIONS
Polymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia.
Jiang
Wei-Min
WM
Department of Cardiovascular Diseases, The First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing. jiangweimin0410@yahoo.com.cn
Tang
Shu-Hua
SH
Lai
Ren-Sheng
RS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016710:Yin Deficiency / Q000235:genetics
D001057:Apolipoproteins E