[Expression and significance of TRAIL receptors in fibroblasts of hypertrophic scar].
OBJECTIVE
To detect the expression of TRAIL receptors in fibroblasts of hypertrophic scar in the proliferative stage and explore its significance.


METHODS
30 samples of hypertrophic scar were taken from 30 burn cases in the proliferative stage. 30 samples of normal skin were taken as the control. The expressions of TRAIL receptors in the fibroblasts of hypertrophic burn scar and the normal skin were assayed by semiquantitative RT-PCR and flowcytometry.


RESULTS
The expression level of DR5 in the fibroblasts of hypertrophic burn scar is much lower than the control (P < 0.05); the expression level of DcR1 in the fibroblasts of hypertrophic burn scar is much higher than the control (P < 0.05).


CONCLUSIONS
The down-regulated DR5 expression and elevated DcR1 expressions in the fibroblasts of hypertrophic burn scar may attribute to the apoptosis change induced by TRAIL and explain the apoptosis differences between the fibroblasts of hypertrophic scar and normal skin to a certain extent.
Leng
Xiang-feng
XF
Department of Burn and Plastic Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Wang
De-chang
DC
Huo
Ran
R
Zhang
Qiu
Q
Xue
Wen-jun
WJ
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D002056:Burns / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D008297:Male; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*; D055815:Young Adult
D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand