title: Isoflavonoids with antiestrogenic activity from Millettia pachycarpa.
abstract: Three new isoflavonoids, named millewanins G (1) and H (2) and furowanin B (3), were isolated from the leaves of Millettia pachycarpa. Their structures were elucidated on the basis of spectroscopic analyses. The antiestrogenic activity in the yeast two-hybrid assay of these isoflavonoids was examined and shown to be comparable with that of 4-hydroxytamoxifen.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
authors.forename: Minako
authors.initials: M
authors.lastname: Kumagaya
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Ueda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nishihara
authors.forename: Nakao
authors.initials: N
authors.lastname: Kojima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D020847:Estrogen Receptor Modulators / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007564:Japan; D033641:Millettia / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D015003:Yeasts / Q000187:drug effects; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors
chemical_list: D020847:Estrogen Receptor Modulators; D007529:Isoflavones; C508678:furowanin B; C508676:millewanin G; C508677:millewanin H; D001616:beta-Galactosidase