title: Bortezomib-induced Sweet's syndrome.
abstract: Sweet's syndrome is an uncommon acute skin disease, associated with a variety of medical problems. The drug-induced variant is even rarer. We describe two cases of this syndrome associated with the administration of the proteasome inhibitor bortezomib. The diagnostic criteria for drug-induced Sweet's syndrome as proposed by Walker and Cohen were fulfilled. Vasculitis and neutrophilic eccrine hidradenitis were excluded.
authors.affiliation: Division of Haematology, Antwerp University Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Van Regenmortel
authors.forename: K
authors.initials: K
authors.lastname: Van de Voorde
authors.forename: H
authors.initials: H
authors.lastname: De Raeve
authors.forename: S
authors.initials: S
authors.lastname: Rombouts
authors.forename: A
authors.initials: A
authors.lastname: Van de Velde
authors.forename: J
authors.initials: J
authors.lastname: Lambert
authors.forename: W
authors.initials: W
authors.lastname: Schroyens
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001897:Boronic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D000069286:Bortezomib; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000139:chemically induced; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008775:Methylprednisolone / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000188:drug therapy; D010146:Pain / Q000139:chemically induced; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D011239:Prednisolone / Q000008:administration & dosage; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D011719:Pyrazines / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D016463:Sweet Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D013733:Testicular Diseases / Q000139:chemically induced
chemical_list: D001897:Boronic Acids; D007166:Immunosuppressive Agents; D011480:Protease Inhibitors; D011719:Pyrazines; D000069286:Bortezomib; D011239:Prednisolone; D008558:Melphalan; D008775:Methylprednisolone