title: Brain tissue oxygenation monitoring in acute brain injury.
abstract: Cerebral ischemia is one of the most important causes of secondary insults following acute brain injury. While intracranial pressure monitoring in the intensive care unit constitutes the cornerstone of neurocritical care monitoring, it does not reflect the state of oxygenation of the injured brain. The holy grail of neuromonitoring is a modality that would reflect accurately real time the status of oxygenation in the tissue of interest, is robust, artefact free and that which provides information that can be used for therapeutic interventions and to improve outcome. Such a device could conceivably be used to augment the sensitivity of current multi-modality monitoring systems in the neurocritical management of brain injured patients. This article examines the availability of data in the literature to support clinical use of local tissue oxygen probes in intensive care.
authors.affiliation: Acute Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, TTSH Campus, Singapore. ivan_ng@nni.com.sg
authors.forename: I
authors.initials: I
authors.lastname: Ng
authors.forename: K K
authors.initials: KK
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Wong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism*; D002404:Catheterization / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D010092:Oximetry / Q000295:instrumentation* / Q000379:methods; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D014159:Transducers
chemical_list: D015415:Biomarkers; D010100:Oxygen