Interleukin-18, neutrophils, and ANCA.
Hewins et al. show that IL-18 is expressed in the kidneys of patients with ANCA-associated glomerulonephritis, and that IL-18 primes neutrophils via p38 MAPK. These findings suggest a role for IL-18, including IL-18-induced T(H)1 polarization and IFN-gamma production, in the progression of ANCA disease.
Pressler
B M
BM
Division of Nephrology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Falk
R J
RJ
Preston
C A
CA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology* / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D020382:Interleukin-18 / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology / Q000502:physiology*; D050199:Podocytes / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D019268:Antibodies, Antineutrophil Cytoplasmic; D020382:Interleukin-18; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D048051:p38 Mitogen-Activated Protein Kinases