Infusion of vasoactive intestinal polypeptide in man: pharmacokinetics and effect on gastric acid secretion.
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers. On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h. Mean plasma VIP concentrations rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the VIP infusions. No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone, and no duodeno-gastric reflux was registered. Serum gastrin concentrations were unaltered during VIP infusion. Elimination of VIP was bi-exponential with half-lives of 2 and 21 min, respectively. Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg.
Holm-Bentzen
M
M
Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.
Christiansen
J
J
Petersen
B
B
Fahrenkrug
J
J
Schultz
A
A
Kirkegaard
P
P
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000008:administration & dosage / Q000493:pharmacokinetics; D012016:Reference Values; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000493:pharmacokinetics*
D005755:Gastrins; D005765:Gastrointestinal Agents; D014660:Vasoactive Intestinal Peptide; D010418:Pentagastrin