Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease.
A genetic susceptibility to depression in PD, acting via the serotonergic system, has been suggested. We examined the influence of allelic variation (L/S) in a functional polymorphism in the serotonin transporter (5-HTTLPR) gene upon mood in 108 PD patients and 82 controls. Using a logistic regression model we found no evidence for an association between 5-HTTLPR genotypes, or the presence of the S allele, and depression.
Burn
David J
DJ
Department of Neurology, University of Newcastle upon Tyne, UK. d.j.burn@ncl.ac.uk
Tiangyou
Watcharee
W
Allcock
Liesl M
LM
Davison
Jill
J
Chinnery
Patrick F
PF
D000368:Aged; D000483:Alleles; D003863:Depression / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D014644:Genetic Variation; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D050486:Serotonin Plasma Membrane Transport Proteins