title: New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizer.
abstract: A simple, rapid and fully automated preparation of sodium [(18)F]fluoroacetate has been developed by taking advantage of the similarities between the reaction pathways of [(18)F]fluoroacetate and [(18)F]-2-fluoro-deoxyglucose (FDG). The automated synthesis of sodium [(18)F]fluoroacetate was achieved with a commercial [(18)F]FDG synthesizer, the TRACERlab MX(FDG). The method produced the desired compound in a short synthesis time (32 min) and with a high and reproducible radiochemical yield (50.2 +/- 4.8%, decay corrected). The radiochemical purity of sodium [(18)F]fluoroacetate was greater than 99%.
authors.affiliation: Biomedical Imaging Research Center, University of Fukui, Yoshida, Japan.
authors.forename: Li-Quan
authors.initials: LQ
authors.lastname: Sun
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.forename: Carmen S
authors.initials: CS
authors.lastname: Dence
authors.forename: Datta E
authors.initials: DE
authors.lastname: Ponde
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Welch
authors.forename: Takako
authors.initials: T
authors.lastname: Furukawa
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Yonekura
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujibayashi
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005462:Fluorine Radioisotopes; D005463:Fluoroacetates / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D012371:Robotics / Q000295:instrumentation* / Q000379:methods
chemical_list: D005462:Fluorine Radioisotopes; D005463:Fluoroacetates; D019275:Radiopharmaceuticals; C014815:fluoroacetic acid