title: Natural regulatory T cells control the development of atherosclerosis in mice.
abstract: Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 689, Centre de Recherche Cardiovasculaire Lariboisière, 41, Bd de la Chapelle, 75010 Paris, France.
authors.forename: Hafid
authors.initials: H
authors.lastname: Ait-Oufella
authors.forename: Benoît L
authors.initials: BL
authors.lastname: Salomon
authors.forename: Stéphane
authors.initials: S
authors.lastname: Potteaux
authors.forename: Anna-Karin L
authors.initials: AK
authors.lastname: Robertson
authors.forename: Pierre
authors.initials: P
authors.lastname: Gourdy
authors.forename: Joffrey
authors.initials: J
authors.lastname: Zoll
authors.forename: Régine
authors.initials: R
authors.lastname: Merval
authors.forename: Bruno
authors.initials: B
authors.lastname: Esposito
authors.forename: José L
authors.initials: JL
authors.lastname: Cohen
authors.forename: Sylvain
authors.initials: S
authors.lastname: Fisson
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
authors.forename: Göran K
authors.initials: GK
authors.lastname: Hansson
authors.forename: David
authors.initials: D
authors.lastname: Klatzmann
authors.forename: Alain
authors.initials: A
authors.lastname: Tedgui
authors.forename: Ziad
authors.initials: Z
authors.lastname: Mallat
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D018122:B7-1 Antigen / Q000235:genetics; D018106:CD28 Antigens / Q000235:genetics; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics; D005260:Female; D007113:Immunity, Innate; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology
chemical_list: D001057:Apolipoproteins E; D018122:B7-1 Antigen; D018106:CD28 Antigens; D004268:DNA-Binding Proteins; C499308:Rag2 protein, mouse