title: Comparison of the EEG-based SNAP index and the Bispectral (BIS) index during sevoflurane-nitrous oxide anaesthesia.
abstract: The BIS monitor (Aspect Medical Inc, Newton, USA) was the first electroencephalogram (EEG)-based monitor of the hypnotic effect reflected by a dimensionless figure ranging from 100 (awake state) to 0 (flat line EEG). Its widespread use makes it the most-studied and the best-known among same intended devices. Its algorithm processes low-frequency EEG oscillations in order to provide the Bispectral index. A BIS index ranging from 40 to 60 has been established as the proper for surgical performance. The BIS monitor permits a closer approach to the hypnotic component of anaesthesia beyond clinical signs and may reduce the probability of intraoperative awareness; therefore, it has become a recommended monitoring tool in routine practice. The SNAP monitor (Nicolet Biomedical, Madison WI, USA) is also intended for monitoring the hypnotic effect of anaesthetics, which is in turn displayed as an index ranging from 100 to 0, with 100 meaning a fully awake state and 0 meaning no brain activity. The algorithm of the SNAP monitor is featured by its additional processing of ultra-high EEG frequencies, which seem to be involved in the formation of consciousness. The use of these frequencies would theoretically improve responsiveness during increased brain activity. We studied its behaviour patterns and capability to monitor the hypnotic effect induced by sevoflurane-nitrous oxide by comparison with the BIS index. Seventy patients ASA I-III were induced with propofol, fentanyl and rocuronium, and maintained with sevoflurane-N(2)O. BIS and SNAP indices were simultaneously recorded before induction, after intubation, after incision, at the following 10, 30 and 50 minutes, awakening and extubation time points, together with heart rate and blood pressure. The Pearson correlation was R(2) = 0.68 (p < .05). The Bland and Altman test showed a bias of 14.3 for SNAP index values with respect to BIS index values. We concluded that the SNAP index correlates with variations in the hypnotic effect induced by sevoflurane-nitrous oxide anaesthesia when compared with the BIS index. In this context, a SNAP index ranging from 58 to 70 would be equivalent to the BIS index range 40 to 60 and, therefore, the accurate for surgical performance.
authors.affiliation: Department of Anaesthesiology and Critical Care, Hospital Clínico Universitario, Av. Blasco Ibañez 17, 46010, Valencia, Spain. patriciarg@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Ruiz-Gimeno
authors.forename: M
authors.initials: M
authors.lastname: Soro
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Solaz
authors.forename: M
authors.initials: M
authors.lastname: Carrau
authors.forename: F J
authors.initials: FJ
authors.lastname: Belda
authors.forename: J L
authors.initials: JL
authors.lastname: Jover
authors.forename: G
authors.initials: G
authors.lastname: Aguilar
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009609:Nitrous Oxide; D000077149:Sevoflurane; D014851:Wakefulness
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D009609:Nitrous Oxide