Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice.
The effects of an ethanol extract of the aerial parts of Ruta chalepensis on the central nervous system (CNS) and LD(50) determination were studied in mice. A crude extract was given systemically and its effects were tested on pentylenetetrazole (PTZ)-induced seizures, sodium pentobarbital-induced hypnosis, exploratory activity, anxiety and nociception. Results from the experimental models tested showed: (1) a delay in the onset of seizures and a dose-dependent suppression in the tonic phase and mortality induced by PTZ; (2) a prolongation of the time of sodium pentobarbital-induced hypnosis; (3) a significant attenuation in the anxiety-response and (4) a reduction in the licking time and shaking behavior in the formalin-induced nociception test. The sedative-hypnotic potentiation, anxiolytic, anticonvulsant and antinociceptive effects suggest that Ruta chalepensis induces a depressant activity on the CNS.
Gonzalez-Trujano
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ME
Direccion de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatria Ramon de la Fuente, Calz. Mexico-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370 Mexico, D.F., Mexico. evag@imp.edu.mx
Carrera
D
D
Ventura-Martinez
R
R
Cedillo-Portugal
E
E
Navarrete
A
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010147:Pain Measurement; D010424:Pentobarbital / Q000633:toxicity; D010433:Pentylenetetrazole / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D032105:Ruta / Q000737:chemistry*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D000431:Ethanol; D010424:Pentobarbital; D010433:Pentylenetetrazole