Identification of a novel HLA B*57 restricted cytotoxic T-lymphocyte epitope within HIV-1 rev.
HLA-B5701 and its related allele B5703 have been shown to be strongly associated with slow HIV-1 disease progression. To elucidate the effect of these alleles fully on disease progression it is essential to identify key HIV-1 epitopes that are restricted by these alleles. Here we describe the identification of a novel HLA-B5701, B5703 restricted epitope within HIV-1 rev, which accounted for up to 25 and 40% of the total cytotoxic T-lymphocyte responses in two patients.
Makadzange
Azure T
AT
Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Gillespie
Geraldine
G
Kimani
Joshua
J
Kiama
Peter
P
Easterbrook
Philippa
P
Bwayo
Job J
JJ
Rowland-Jones
Sarah L
SL
D000208:Acute Disease; D002908:Chronic Disease; D018450:Disease Progression; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D015235:HLA-B Antigens; C103707:HLA-B57 antigen