title: Calcium-activated potassium channels and the regulation of vascular tone.
abstract: Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium signals and targets represent multilayered opportunities for prevention and/or treatment of vascular dysfunctions.
authors.affiliation: Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ledoux
authors.forename: Matthias E
authors.initials: ME
authors.lastname: Werner
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Brayden
authors.forename: Mark T
authors.initials: MT
authors.lastname: Nelson
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D024681:Potassium Channels, Calcium-Activated / Q000145:classification / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction
chemical_list: D024681:Potassium Channels, Calcium-Activated; D002118:Calcium