title: Functional variants of the lipoprotein lipase gene and the risk of preeclampsia among non-Hispanic Caucasian women.
abstract: Hypertriglyceridemia is an important pathophysiologic feature of preeclampsia, a common vascular disorder of pregnancy. Three well-documented functional variants (N291S, S447X, and D9N) of the lipoprotein lipase gene were related to hypertriglyceridemia. Results from the only two studies concerning the relationship between these variants and preeclampsia risk have been inconsistent. We investigated this relationship in a case-control study including 144 preeclamptic and 290 normotensive pregnant women (all non-Hispanic Caucasians). We estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for maternal age, pre-pregnancy body mass index, and parity. After adjusting for covariates, women with the 291 N/S or S/S genotype had significantly increased risk of preeclampsia (OR 6.9, 95% CI 1.9-25.4) compared with women with the common 291N/N genotype. The 447 S/X or X/X genotype was not significantly associated with preeclampsia risk. The frequency of the 9N variant allele was 1.8% in controls, while this allele was not observed among cases. Haplotype 9D/291S/447S was strongly associated with higher risk of preeclampsia as compared with the most common haplotype 9D/291N/447S (adjusted OR 6.6, 95% CI 1.7-25.0). Results from our study support the thesis that abnormal lipid metabolism is important in the pathogenesis of preeclampsia.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. nhcui@channing.harvard.edu
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: M A
authors.initials: MA
authors.lastname: Austin
authors.forename: K L
authors.initials: KL
authors.lastname: Edwards
authors.forename: F M
authors.initials: FM
authors.lastname: Farin
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Hsu
authors.forename: S L
authors.initials: SL
authors.lastname: Srinouanprachanh
authors.forename: M A
authors.initials: MA
authors.lastname: Williams
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics / Q000473:pathology; D008071:Lipoprotein Lipase / Q000097:blood / Q000235:genetics*; D011225:Pre-Eclampsia / Q000201:enzymology / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: D008071:Lipoprotein Lipase