Correlations between longitudinal changes in transitional zone volume and measures of benign prostatic hyperplasia in a population-based cohort.
OBJECTIVE
To determine whether measures of transitional zone volume (TZV) are more strongly associated than total prostate volume with longitudinal urologic outcomes.


METHODS
In 1990, 2,115 randomly selected Caucasian men from Olmsted County, Minnesota (USA) completed validated questionnaires during a home visit. A 25% subsample underwent clinical evaluation that included transrectal ultrasonography, assessment of serum prostate-specific antigen levels, and maximum urinary flow rates. Examinations and questionnaires were repeated biennially through 2004. TZV measures were taken at the fifth through eighth visits. Men with at least one TZV measurement were included in this study (n=336).


RESULTS
Changes in TZV correlated weakly with changes in peak urinary flow rate and urinary symptoms. After accounting for age and change in total prostate volume, change in TZV added no information to models that predict changes in urinary symptoms and peak urinary flow rates. Men who experienced the most rapid annual changes in TZV were not more likely to experience more rapid changes in urinary symptoms or maximum flow rate.


CONCLUSIONS
Tracking changes in TZV over time may be unlikely to provide a good surrogate measure for the development of benign prostatic hyperplasia.
St Sauver
Jennifer L
JL
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Jacobson
Debra J
DJ
Girman
Cynthia J
CJ
McGree
Michaela E
ME
Lieber
Michael M
MM
Jacobsen
Steven J
SJ
D015331:Cohort Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D014555:Urination Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology