title: Solid-phase chemistry in the total synthesis of non-peptidic natural products.
abstract: Solid-phase chemistry, first introduced for peptide synthesis in the 1960's, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.
authors.affiliation: Biomedical Research Institute, Barcelona Scientific Park-University of Barcelona, 08028 Barcelona, Spain. pablo_cironi@dfci.harvard.edu
authors.forename: Pablo
authors.initials: P
authors.lastname: Cironi
authors.forename: Mercedes
authors.initials: M
authors.lastname: Alvarez
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003374:Coumarins / Q000138:chemical synthesis; D034261:Epothilones / Q000138:chemical synthesis; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D010879:Piperazines / Q000138:chemical synthesis; D011453:Prostaglandins / Q000138:chemical synthesis; D011799:Quinazolines / Q000138:chemical synthesis; D014364:Tryptophan / Q000031:analogs & derivatives / Q000138:chemical synthesis
chemical_list: D000470:Alkaloids; D001688:Biological Products; D003374:Coumarins; D034261:Epothilones; D004364:Pharmaceutical Preparations; D010879:Piperazines; D011453:Prostaglandins; D011799:Quinazolines; C100698:demethoxyfumitremorgin C; C445696:verrucine A; C445697:verrucine B; C075514:glyantrypine; D014364:Tryptophan