title: [Factor VIII hyperactivity: an arterio-venous thrombogenic factor. Case report].
abstract: Thrombosis is the principal mechanism in vascular pathology, whether cerebral, coronary or peripheral. During the initial stages of infarction, coagulation contributes to vascular occlusion, the haemostatic factors playing a determining role in the development of atherothrombotic lesions. An increase in a coagulation protein, besides any lowering of anticoagulation protein levels, is a risk factor for thrombosis. Among these pro-coagulant factors, the pro-thrombogenic action of factor VIII has without doubt been studied the least. We report the case of a 62 year old patient with a personal and family history of many previous thrombotic episodes, both arterial and venous, in whom factor VIII hyperactivity was discovered after a myocardial infarction. This case underlines the association of the factor VIII complex with thrombosis, and its clinical repercussions, especially the incidence of coronary pathology.
authors.affiliation: Département de cardiologie et maladies vasculaires, Centre cardio-pneumologique niveau 6, hôpital Pontchaillou, CHU, 35033 Rennes.
authors.forename: S L
authors.initials: SL
authors.lastname: Bennani
authors.forename: B
authors.initials: B
authors.lastname: Vaquette
authors.forename: D
authors.initials: D
authors.lastname: Pavin
authors.forename: D
authors.initials: D
authors.lastname: Boulmier
authors.forename: J C
authors.initials: JC
authors.lastname: Daubert
authors.forename: P
authors.initials: P
authors.lastname: Mabo
mesh_terms: D003328:Coronary Thrombosis / Q000235:genetics / Q000378:metabolism*; D005169:Factor VIII / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D020246:Venous Thrombosis / Q000235:genetics / Q000378:metabolism*
chemical_list: D005169:Factor VIII