title: Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors.
abstract: A new type of noncompetitive alpha-2,3-sialyltransferase inhibitor has been synthesized; we report the discovery, preparation and inhibitory activity of sixteen lithocholic acid analogues.
authors.affiliation: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Kai-Hsuan
authors.initials: KH
authors.lastname: Chang
authors.forename: Lenselot
authors.initials: L
authors.lastname: Lee
authors.forename: Jessica
authors.initials: J
authors.lastname: Chen
authors.forename: Wen-Shan
authors.initials: WS
authors.lastname: Li
mesh_terms: D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008095:Lithocholic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D008956:Models, Chemical; D012794:Sialic Acids / Q000737:chemistry; D012799:Sialyltransferases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D012794:Sialic Acids; D008095:Lithocholic Acid; D012799:Sialyltransferases; C029156:N-acetyllactosaminide alpha-2,3-sialyltransferase