title: Stability of heterogeneous elastography phantoms made from oil dispersions in aqueous gels.
abstract: A set of five tissue-mimicking phantoms with cylindrical inclusions were produced for assessing long-term stability of geometry and elastic properties and assessing accuracy of determination of elastic properties. The base aqueous materials were either gelatin or a mixture of agar and gelatin. Stiffness was controlled by selection of the volume percent consisting of microscopic safflower oil droplets. Cylinder diameters remained unchanged within 1% or 2% over many months. Strain ratios from elastograms of the phantoms were stable over many months, implying that elastic contrasts were also stable. Test samples, called production samples, for measurement of Young's moduli were made at the time of manufacture of each phantom and were stored separately from one another. Each production sample was homogeneous and consisted of either inclusion material or background material. For all five phantoms, it was found that the elastic contrast computed using Young's modulus values determined using the production samples accurately represented the true elastic contrasts in the corresponding phantom. This finding was established by the fact that the (true) elastic contrasts determined using samples excised from the phantoms themselves agreed with the elastic contrasts obtained using the homogeneous production samples.
authors.affiliation: Department of Medical Physics, University of Wisconsin, Madison, WI 53706, USA. elmadsen@wisc.edu
authors.forename: Ernest L
authors.initials: EL
authors.lastname: Madsen
authors.forename: Maritza A
authors.initials: MA
authors.lastname: Hobson
authors.forename: Hairong
authors.initials: H
authors.lastname: Shi
authors.forename: Tomy
authors.initials: T
authors.lastname: Varghese
authors.forename: Gary R
authors.initials: GR
authors.lastname: Frank
mesh_terms: D000362:Agar; D004548:Elasticity; D004867:Equipment Design; D005780:Gelatin; D005782:Gels; D009821:Oils; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D013314:Stress, Mechanical; D014463:Ultrasonography
chemical_list: D005782:Gels; D009821:Oils; D005780:Gelatin; D000362:Agar