title: Class 2 integron-associated antibiotic resistance in Shigella sonnei isolates in Dakar, Senegal.
abstract: Forty-three Shigella sonnei isolates from adult patients with diarrhoea in Dakar were analysed for the presence of integrons. Isolates were resistant to sulphamethoxazole, trimethoprim, tetracycline, streptomycin and spectinomycin. A high prevalence of class 2 integrons (93%) was found. These integrons showed three distinct structures: a class 2 integron, part of the Tn7 family and its derivatives, carrying four cassettes in the order dfrA1-sat-aadA1-orfX; a truncated class 2 integron, without orfX; and a third type ca. 4 kb in size. These class 2 integrons probably play a role in the spread of multiresistance in S. sonnei isolates. To our knowledge, this is the first description of class 2 integrons in S. sonnei isolated in sub-Saharan Africa.
authors.affiliation: Laboratoire de Bactériologie Expérimentale, Institut Pasteur, BP 220, Dakar, Sénégal. gassama@pasteur.sn
authors.forename: A
authors.initials: A
authors.lastname: Gassama-Sow
authors.forename: M H
authors.initials: MH
authors.lastname: Diallo
authors.forename: C S
authors.initials: CS
authors.lastname: Boye
authors.forename: B
authors.initials: B
authors.lastname: Garin
authors.forename: J M
authors.initials: JM
authors.lastname: Sire
authors.forename: A I
authors.initials: AI
authors.lastname: Sow
authors.forename: A
authors.initials: A
authors.lastname: Aïdara-Kane
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003967:Diarrhea / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D032023:Integrons; D015995:Prevalence; D012675:Senegal; D012764:Shigella sonnei / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents