title: Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease.
abstract: OBJECTIVE
  To determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer.
  
  
  METHODS
  Retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant.
  
  
  RESULTS
  A total of 73 patients were studied in this period. Fifteen patients (20.5%) had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively). The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48) years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p < 0.07). No relationship was seen between type of gastric reconstruction (Billroth I or II) and rate of Helicobacter pylori detection.
  
  
  CONCLUSIONS
  Helicobacter pylori infection is frequent in patients with previous gastrectomy for non-neoplastic disease. The results of the study suggest that Helicobacter pylori infection may play a role in gastric stump cancer.
authors.affiliation: Service of Gastroenterology, Hospital del Mar, Universidad Autónoma de Barcelona, Spain. 92847@imas.imim.es
authors.forename: A
authors.initials: A
authors.lastname: Seoane
authors.forename: X
authors.initials: X
authors.lastname: Bessa
authors.forename: F
authors.initials: F
authors.lastname: Alameda
authors.forename: A
authors.initials: A
authors.lastname: Munné
authors.forename: M
authors.initials: M
authors.lastname: Gallen
authors.forename: S
authors.initials: S
authors.lastname: Navarro
authors.forename: E
authors.initials: E
authors.lastname: O'Callaghan
authors.forename: A
authors.initials: A
authors.lastname: Panadès
authors.forename: M
authors.initials: M
authors.lastname: Andreu
authors.forename: F
authors.initials: F
authors.lastname: Bory
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D005260:Female; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D018530:Gastric Stump / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D013276:Stomach Ulcer / Q000382:microbiology* / Q000601:surgery