title: Certainly can't live without this: SIRT6.
abstract: Cellular metabolic rates might regulate aging by impinging on genomic stability through the DNA repair pathways. A new study published in Cell (Mostoslavsky et al., 2006) reports that deficiency in one of the mammalian Sir2 homologs, SIRT6, results in genome instability through the DNA base excision repair pathway and leads to aging-associated degenerative phenotypes.
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Rodgers
authors.forename: Pere
authors.initials: P
authors.lastname: Puigserver
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004260:DNA Repair / Q000502:physiology*; D042822:Genomic Instability / Q000502:physiology*; D006655:Histone Deacetylases / Q000378:metabolism; D008136:Longevity; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000378:metabolism; D056565:Sirtuin 2; D037761:Sirtuins / Q000378:metabolism*; D015003:Yeasts
chemical_list: D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; C501860:Sirt6 protein, mouse; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases