[Effect of long tubular bone fracture on serum levels of leptin, acute phase proteins and biochemical markers for organ functions].
OBJECTIVE
To investigate the effect of long tubular bone fracture (LTBF) on serum levels of leptin, acute phase proteins and biochemical markers for organ functions, and to look for the role of leptin in traumatic inflammatory responses.


METHODS
Serum samples of LTBF patients and normal controls were collected, and immunoassays were used to determine serum levels of leptin and three acute phase proteins, including C-reactive protein (CRP), interleukin-1 (IL-1) and IL-2, and 21 biochemical markers for organ and metabolic functions were measured simultaneously with automatic biochemical analyzer. Correlation between leptin and all the markers was then analyzed.


RESULTS
Compared with normal control, serum levels of leptin, CRP, IL-1 and IL-2 increased significantly (all P<0.05), with various degrees of changes in the markers for hepatic, cardiac, renal and metabolic functions. Leptin was independent to all the markers investigated, and it seemed to exert its unique roles.


CONCLUSIONS
Leptin increases significantly in LTBF-induced acute traumatic inflammatory response, showing a comparatively strong responsiveness to the stimulation, and it may play a role as an anti-inflammatory cytokine.
Lin
Ji
J
Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, Beijing 100853, China.
Yan
Guang-tao
GT
Wang
Lu-huan
LH
Xue
Hui
H
Hao
Xiu-hua
XH
Zhang
Kai
K
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D050723:Fractures, Bone / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged
D000209:Acute-Phase Proteins; D015415:Biomarkers; D007375:Interleukin-1; D007376:Interleukin-2; D020738:Leptin; D002097:C-Reactive Protein