Supportive periodontal therapy using mechanical instrumentation or 2% minocycline gel: a 12 month randomized, controlled, single masked pilot study.
OBJECTIVE
To compare the short-term performance of subgingival local delivery of 2% minocycline gel and conventional subgingival debridement in supportive periodontal therapy (SPT) patients.


METHODS
Forty adult patients having completed active treatment for moderate to advanced chronic periodontitis were included in a randomized, controlled, single masked maintenance care pilot study. Sites with residual pocket probing depths > or =5 mm and bleeding on probing were treated with either minocycline gel (minocycline-group) or scaling and root planing only (debridement-group) at baseline, 3, 6, and 9 months. Clinical and microbiological examinations were performed at baseline, 3, 6, 9, and 12 months.


RESULTS
Full-mouth plaque and bleeding scores remained <10% and <20%, respectively, for both groups throughout the study. In both groups there was a persistent reduction in number of teeth and sites with probing pocket depths > or =5 mm (p<0.05) with no significant differences between the groups. The prevalence of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Prevotella nigrescens, remained at levels < or =10(5) in the majority of patients and sites in both groups.


CONCLUSIONS
This pilot study failed to show a difference between local delivery of 2% minocycline gel as mono-therapy and traditional subgingival debridement in patients on SPT.
McColl
E
E
Department of Periodontology, Eastman Dental Institute, University College London, London, UK.
Patel
K
K
Dahlen
G
G
Tonetti
M
M
Graziani
F
F
Suvan
J
J
Laurell
L
L
D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001439:Bacteroides / Q000187:drug effects; D015169:Colony Count, Microbial; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D010865:Pilot Projects; D016966:Porphyromonas gingivalis / Q000187:drug effects; D018713:Prevotella intermedia / Q000187:drug effects; D045242:Prevotella nigrescens / Q000187:drug effects; D016745:Root Planing; D016037:Single-Blind Method; D048373:Treponema denticola / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005782:Gels; D008911:Minocycline