title: Tissue penetration of telavancin after intravenous administration in healthy subjects.
abstract: The pharmacokinetic disposition of telavancin administered 7.5 mg/kg of body weight every 24 h was determined in plasma and skin blister fluid. The mean penetration of telavancin into blister fluid was 40%. This study reveals that adequate concentrations are achieved in both plasma and blister fluid for pathogens frequently implicated in skin and soft tissue infections.
authors.affiliation: Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA.
authors.forename: Heather K
authors.initials: HK
authors.lastname: Sun
authors.forename: Kenneth
authors.initials: K
authors.lastname: Duchin
authors.forename: Charles H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: Jeng-Pyng
authors.initials: JP
authors.lastname: Shaw
authors.forename: Julie
authors.initials: J
authors.lastname: Seroogy
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
mesh_terms: D000328:Adult; D000617:Aminoglycosides / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006801:Humans; D007262:Infusions, Intravenous; D000077427:Lipoglycopeptides; D008875:Middle Aged; D010539:Permeability; D011485:Protein Binding; D051381:Rats
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; C487637:telavancin