New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizer.
A simple, rapid and fully automated preparation of sodium [(18)F]fluoroacetate has been developed by taking advantage of the similarities between the reaction pathways of [(18)F]fluoroacetate and [(18)F]-2-fluoro-deoxyglucose (FDG). The automated synthesis of sodium [(18)F]fluoroacetate was achieved with a commercial [(18)F]FDG synthesizer, the TRACERlab MX(FDG). The method produced the desired compound in a short synthesis time (32 min) and with a high and reproducible radiochemical yield (50.2 +/- 4.8%, decay corrected). The radiochemical purity of sodium [(18)F]fluoroacetate was greater than 99%.
Sun
Li-Quan
LQ
Biomedical Imaging Research Center, University of Fukui, Yoshida, Japan.
Mori
Tetsuya
T
Dence
Carmen S
CS
Ponde
Datta E
DE
Welch
Michael J
MJ
Furukawa
Takako
T
Yonekura
Yoshiharu
Y
Fujibayashi
Yasuhisa
Y
D004867:Equipment Design; D019544:Equipment Failure Analysis; D005462:Fluorine Radioisotopes; D005463:Fluoroacetates / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D012371:Robotics / Q000295:instrumentation* / Q000379:methods
D005462:Fluorine Radioisotopes; D005463:Fluoroacetates; D019275:Radiopharmaceuticals; C014815:fluoroacetic acid