Regulatory dendritic cells modulate immune responses via induction of T-cell apoptotic death.
We describe a regulatory lymphoid dendritic cell (LDC) population propagated from mouse liver nonparenchymal cells (NPC) in IL-3 and anti-CD40 monoclonal antibody that are phenotypically mature, and induce T-cell hyporesponsiveness by promoting T-cell apoptotic death, which is partially caspase-dependent, but is unlikely to be mediated by soluble factor(s). In vivo administration of liver LDC significantly prolonged the survival of vascularized cardiac allografts in an alloantigen-specific manner. This is associated with enhanced T-cell death in secondary lymphoid organs.
Liang
Xiaoyan
X
Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.
Chen
Zongyou
Z
Fung
John J
JJ
Qian
Shiguang
S
Lu
Lina
L
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D018929:Cell Culture Techniques; D003713:Dendritic Cells / Q000502:physiology*; D006085:Graft Survival / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology*; D020287:In Situ Nick-End Labeling; D017493:Leukocyte Common Antigens / Q000502:physiology*; D008099:Liver / Q000166:cytology* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000502:physiology*
D017493:Leukocyte Common Antigens