STAT3 in immune responses and inflammatory bowel diseases.
STAT3 has been known as a mediator for gene expression induced by many important cytokines. Recent studies have suggested that STAT3 has important functions in regulation of both innate and adaptive immunity. Loss of STAT3 in immune cells caused severe inflammation in response to pathogens. This review discusses the recent progress and suggests directions for the future research on this interesting molecule.
Fu
Xin Yuan
XY
Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 635 Barnhill Drive, MS 420, Indianapolis, IN 46202-5120, USA. xfu@IUPUI.edu
D000818:Animals; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics / Q000276:immunology; D050796:STAT3 Transcription Factor / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D016207:Cytokines; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D050796:STAT3 Transcription Factor; D016753:Interleukin-10