Lupane triterpenoids and a diarylheptanoid from Clematoclethra actinidioides.
Three new compounds, actinidione ( 1), 3 beta,29-dihydroxylup-20(30)-en-28-al ( 2) and 3 beta- O- trans-caffeoyl-29-hydroxybetulin ( 3), along with twenty known compounds ( 4 - 23), were isolated from the leaves and twigs of Clematoclethra actinidioides Maxim. Their structures were determined by analysis of spectral data or comparison with authentic samples. Compounds 1, 2 and 3 exhibited cytotoxicity against Lu-06, N-04 and Bre-04 cell lines with GI (50) values of 15.02 - 41.64 microg/mL.
Chengdu Institute of Biology, The Chinese Academy of Sciences, Chengdu 610041, P. R. China.
Hui
H
Guo
Bo-Gang
BG
Li
Zhi-Jun
ZJ
Wu
Guo-Lin
GL
Zhang
D029041:Actinidiaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053978:Pentacyclic Triterpenes
D003603:Cytotoxins; D036381:Diarylheptanoids; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes