Potent algicides based on the cyanobacterial alkaloid nostocarboline.
[structure: see text] Nostocarboline and seven derivatives were prepared and displayed minimal inhibitory concentration (MIC) values >or=100 nM against the growth of Microcystis aeruginosa PCC 7806, Synechococcus PCC 6911, and Kirchneriella contorta SAG 11.81, probably via the inhibition of photosynthesis. The natural product hybrid nostocarboline/ciprofloxacin displayed additional antibacterial activity against several Gram-negative bacteria (MICs >or=0.7 microM). Nostocarboline can thus be considered a potent, selective, readily available, natural algicide.
Institute of Plant Biology, University of Zürich, Seestr. 187, CH-8802 Kilchberg.
Judith F
JF
Blom
Tobias
T
Brütsch
Damien
D
Barbaras
Yann
Y
Bethuel
Hans H
HH
Locher
Christian
C
Hubschwerlen
Karl
K
Gademann
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000460:Chlorophyta / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D046931:Microcystis / Q000187:drug effects*; D015394:Molecular Structure; D046940:Synechococcus / Q000187:drug effects*
D000470:Alkaloids; D000890:Anti-Infective Agents; D002243:Carbolines; C507037:nostocarboline