An abnormal accumulation of fluorine-18-FDG PET in cytomegalovirus enteritis--a case report.
The source of a fever of unknown origin (FUO) and watery diarrhea in a 63-yr-old female with a history of disturbance of consciousness due to moyamoya disease was examined. Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET), colonoscopy, blood analysis, and determination of cytomegalovirus (CMV) antigenemia were performed. FDG was found to be accumulated in the wall of a dilated colon, and extended from the transverse to sigmoid colon. Colonoscopy revealed edematous, inflammatory, and punched out lesions in accordance with the areas of abnormal FDG uptake. A biopsy specimen showed the antibody of CMV in the colonic mucosa, and CMV antigenemia was detected by an immunohistochemical assay using a monoclonal antibody for CMV pp65 antigen. From these findings, we strongly suspected CMV enteritis.
Department of Radiology, National Center for Geriatrics and Gerontology, Ohbu, Japan. dr284@hotmail.com
Takashi
T
Nihashi
Kengo
K
Ito
Takashi
T
Kato
Rikio
R
Kato
Makiko
M
Okuda
Toru
T
Arima
Masahiko
M
Bundo
Shoji
S
Kawatsu
Kazumasa
K
Hayasaka
Takeo
T
Ishigaki
D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000382:microbiology; D004751:Enteritis / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000382:microbiology; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis / Q000209:etiology; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18