Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes.
The first platinum-catalyzed selective silylation of aryl halides including aryl iodides and bromides having an electron-withdrawing group is described. The reaction takes place rapidly in NMP with triethylsilane as a silicon source and sodium acetate to provide functionalized aryltriethylsilanes in moderate to good yields. Heteroaromatic halides also were found to be readily silylated with triethylsilane. The procedure is chemoselective and tolerates a wide variety of functional groups.
Laboratoire de Chimie Thérapeutique, BioCIS - CNRS (UMR 8076), Université Paris-Sud XI, Faculté de Pharmacie, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
Abdallah
A
Hamze
Olivier
O
Provot
Mouâd
M
Alami
Jean-Daniel
JD
Brion
D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry
D006846:Hydrocarbons, Halogenated; D010087:Oxides; D012821:Silanes; C514637:platinum oxide; D010984:Platinum