Ras signaling on the Golgi.
The discovery that Ras proteins are modified by enzymes restricted to the endoplasmic reticulum and Golgi apparatus and that, at steady state, a significant pool of Ras is localized on the Golgi has led to the hypothesis that Ras can become activated on and signal from intracellular membranes. Fluorescent probes capable of showing when and where in living cells Ras becomes activated together with studies of Ras proteins stringently tethered to intracellular membranes have confirmed this hypothesis. Thus, recent studies of Ras have contributed to the rapidly expanding field of compartmentalized signaling.
Quatela
Steven E
SE
Department of Pharmacology, MSB 251, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Philips
Mark R
MR
D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology*; D018631:ras Proteins / Q000378:metabolism / Q000502:physiology*
D018631:ras Proteins