Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD.
OBJECTIVE
The objective of this study was to investigate the association between antioxidant nutrients and markers of oxidative stress with pulmonary function in persons with chronic airflow limitation.


METHODS
Cross-sectional study exploring the association of antioxidant nutrients and markers of oxidative stress with forced expiratory volume in the first second (FEV1%) and forced vital capacity (FVC%).


METHODS
The study data included 218 persons with chronic airflow limitation recruited randomly from the general population of Erie and Niagara counties, New York State, USA.


RESULTS
After adjustment for covariates, multiple linear regression analysis showed that serum beta-cryptoxanthin, lutein/zeaxanthin, and retinol, and dietary beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, vitamin C, and lycopene were positively associated with FEV1% (P < 0.05, all associations). Serum vitamins beta-cryptoxanthin, lutein/zeaxanthin, and lycopene, and dietary beta-cryptoxanthin, beta-carotene, vitamin C, and lutein/zeaxanthin were positively associated with FVC% (P < 0.05, all associations). Erythrocytic glutathione was negatively associated with FEV1%, while plasma thiobarbituric acid-reactive substances (TBARS) were negatively associated with FVC% (P < 0.05).


CONCLUSIONS
These results support the hypothesis that an imbalance in antioxidant/oxidant status is associated with chronic airflow limitation, and that dietary habits and/or oxidative stress play contributing roles.
Ochs-Balcom
H M
HM
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Grant
B J B
BJ
Muti
P
P
Sempos
C T
CT
Freudenheim
J L
JL
Browne
R W
RW
McCann
S E
SE
Trevisan
M
M
Cassano
P A
PA
Iacoviello
L
L
Schünemann
H J
HJ
D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism / Q000502:physiology*; D001249:Asthma / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D016014:Linear Models; D015999:Multivariate Analysis; D009518:New York; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D012119:Respiration; D012129:Respiratory Function Tests; D012307:Risk Factors; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014797:Vital Capacity / Q000502:physiology
D000975:Antioxidants; D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D005978:Glutathione