Suppression of atopic dermatitis and tumor metastasis in mice by small amounts of radon.
We examined the effect of radon in two experimental disease models in mice by administering radon dissolved in water at 68-203 Bq/liter. Administration of radon in drinking water to NC/Nga mice significantly delayed the progression of atopic dermatitis-like skin lesions induced by picrylchloride when administered prior to the induction of disease signs. The number of pulmonary metastatic foci in C57BL/6 mice inoculated with B16 melanoma cells was also reduced significantly by administration of radon in drinking water when the number of tumor cells was small and the radon treatment was started prior to tumor inoculation. The ratio of Ifng to Il4 produced by splenocytes from BALB/c mice immunized with DNP-Ascaris was significantly increased by administration of radon in drinking water. From these results, a modulation of immunity by radon was suggested.
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. mtaka@rs.noda.tus.ac.jp
Mareyuki
M
Takahashi
Shuji
S
Kojima
D000818:Animals; D045744:Cell Line, Tumor; D003876:Dermatitis, Atopic / Q000473:pathology* / Q000532:radiotherapy*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control* / Q000532:radiotherapy*; D011886:Radon / Q000627:therapeutic use*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D023041:Xenograft Model Antitumor Assays
D011886:Radon