A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa.
The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent global transcriptome and proteome analyses provided a wealth of information about the identity of the regulated genes, N-acyl-homoserine lactone signal specificity, timing of induction, and environmental effects on gene expression. Quorum-sensing gene expression in P. aeruginosa is also embedded in a highly interconnected network of other regulatory systems with a high potential for integrating and responding to multiple environmental signals. Such epigenetic complexity may constitute the basis for the exceptional adaptability of P. aeruginosa to diverse environments.
Schuster
Martin
M
Department of Microbiology, University of Washington, 1959 NE Pacific Street, HSB I-420, Seattle, WA 98195, USA.
Greenberg
E Peter
EP
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000502:physiology; D002265:Carboxylic Ester Hydrolases / Q000235:genetics; D002450:Cell Communication / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
C088386:homoserine lactone; D002265:Carboxylic Ester Hydrolases; C432003:N-acyl homoserine lactonase; D015107:4-Butyrolactone