The odyssey of k-ras.
A mechanism that regulates K-Ras signaling specificity by altering its subcellular location is presented by Bivona et al. (2006). Phosphorylation of its membrane-anchoring domain by PKC drives K-Ras off of the plasma membrane and onto the outer mitochondrial membrane where it induces cell death.
Department of Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Larry A
LA
Feig
D000818:Animals; D016923:Cell Death / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D011905:Genes, ras; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000648:ultrastructure; D011493:Protein Kinase C / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D051020:bcl-X Protein / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D051020:bcl-X Protein; D011493:Protein Kinase C