Urinary dysfunction and autonomic control in amyloid neuropathy.
Uro-neurological assessment was performed in four patients with small-fiber neuropathy due to amyloidosis (2 transthyretin-type/2 immunoglobulin light-chain-type). Voiding difficulties were due to detrusor weakness and impaired bladder sensation. In two patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity. The underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves.
Neurology Dept., Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan.
Takashi
T
Ito
Ryuji
R
Sakakibara
Tatsuya
T
Yamamoto
Tomoyuki
T
Uchiyama
Zhi
Z
Liu
Masato
M
Asahina
Morihiro
M
Higashi
Kimihito
K
Arai
Shoichi
S
Ito
Yusuke
Y
Awa
Kaori
K
Yamamoto
Mika
M
Kinou
Tomonori
T
Yamanishi
Takamichi
T
Hattori
D000368:Aged; D000369:Aged, 80 and over; D017772:Amyloid Neuropathies / Q000503:physiopathology*; D000686:Amyloidosis / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002799:Cholinergic Fibers / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000503:physiopathology; D009475:Neurons, Afferent / Q000502:physiology; D011228:Prealbumin / Q000502:physiology; D012189:Retrospective Studies; D001743:Urinary Bladder / Q000294:innervation; D014549:Urinary Incontinence / Q000503:physiopathology; D016055:Urinary Retention / Q000503:physiopathology; D014551:Urinary Tract / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology*
D011228:Prealbumin