Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men.
Consumption of some dietary fibres may benefit bowel health; however, the effect of Australian sweet lupin (Lupinus angustifolius) kernel fibre (LKFibre) is unknown. The present study examined the effect of a high-fibre diet containing LKFibre on bowel function and faecal putative risk factors for colon cancer compared to a control diet without LKFibre. Thirty-eight free-living, healthy men consumed an LKFibre and a control diet for 1 month each in a single-blind, randomized, crossover study. Depending on subject energy intake, the LKFibre diet was designed to provide 17-30 g/d fibre (in experimental foods) above that of the control diet. Bowel function self-perception, frequency of defecation, transit time, faecal output, pH and moisture, faecal levels of SCFA and ammonia, and faecal bacterial beta-glucuronidase activity were assessed. In comparison to the control diet, the LKFibre diet increased frequency of defecation by 0.13 events/d (P=0.047), increased faecal output by 21 % (P=0.020) and increased faecal moisture content by 1.6 % units (P=0.027), whilst decreasing transit time by 17 % (P=0.012) and decreasing faecal pH by 0.26 units (P<0.001). Faecal butyrate concentration was increased by 16 % (P=0.006), butyrate output was increased by 40 % (P=0.002) and beta-glucuronidase activity was lowered by 1.4 micromol/h per g wet faeces compared to the control diet (P<0.001). Addition of LKFibre to the diet incorporated into food products improved some markers of healthy bowel function and colon cancer risk in men.
Johnson
Stuart K
SK
School of Exercise and Nutrition Sciences, Faculty of Health and Behavioural Sciences, Deakin University, 221 Burwood Hwy, Burwood, Victoria, 3125, Australia. stukj@deakin.edu.au
Chua
Veronica
V
Hall
Ramon S
RS
Baxter
Amynta L
AL
D000328:Adult; D000641:Ammonia / Q000032:analysis; D001835:Body Weight / Q000502:physiology; D003110:Colonic Neoplasms / Q000209:etiology* / Q000378:metabolism; D018592:Cross-Over Studies; D003672:Defecation / Q000502:physiology; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage*; D004435:Eating / Q000502:physiology; D005232:Fatty Acids, Volatile / Q000032:analysis; D005243:Feces / Q000737:chemistry / Q000201:enzymology; D005772:Gastrointestinal Transit / Q000502:physiology; D005966:Glucuronidase / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007422:Intestines / Q000502:physiology*; D031297:Lupinus; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016037:Single-Blind Method
D004043:Dietary Fiber; D005232:Fatty Acids, Volatile; D000641:Ammonia; D005966:Glucuronidase