Abietanes from Plectranthus grandidentatus and P. hereroensis against methicillin- and vancomycin-resistant bacteria.
The antimicrobial activity of 10 natural abietanes isolated from Plectranthus grandidentatus and P. hereroensis acetonic extract was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The results revealed that the most active diterpenes were coleon U (1), 7alpha-acetoxy-6beta-hydroxyroyleanone (2) and horminone (3). Minimum inhibitory concentration (MIC) values ranging 0.98-15.63 microg/ml were obtained for MRSA clinical strains, and MIC values of 15.63 and 31.25 microg/ml were obtained for VRE clinical strains. Some structure-activity relationships are emphasized.
Faculdade de Farmácia, Universidade de Lisboa, CECF, Lisboa, Portugal.
C
C
Gaspar-Marques
P
P
Rijo
M F
MF
Simões
M A
MA
Duarte
B
B
Rodriguez
D045784:Abietanes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000096:Acetone / Q000737:chemistry; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016983:Enterococcus / Q000187:drug effects*; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D031346:Plectranthus / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D020713:Vancomycin Resistance / Q000187:drug effects
D045784:Abietanes; D000890:Anti-Infective Agents; D010936:Plant Extracts; D000096:Acetone