A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris.
A balanced translocation was recently identified in a German psoriasis patient. One of the breakpoints was mapped immediately upstream of the microsomal glutathione S-transferase 2 (MGST2) gene, suggesting it as a candidate gene. Here, we report the identification of a novel non-synonymous mutation in MGST2 by a comprehensive sequence analysis of MGST2's coding region in Chinese psoriasis samples. We demonstrate that this mutation co-segregated with the disease phenotype within a Chinese family affected with psoriasis vulgaris and is predicted to have an impact on the normal function of MGST2 protein. However, the mutation was absent in 551 additional cases and 384 healthy Chinese controls. While requiring independent confirmation, our results suggest that this rare mutation could play a causal role in a small subset of psoriasis individuals.
Institute of Dermatology & Department of Dermatology at No. 1 Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China.
Kai-Lin
KL
Yan
Xue-Jun
XJ
Zhang
Zhi-Min
ZM
Wang
Sen
S
Yang
Guo-Long
GL
Zhang
Jian
J
Wang
Feng-Li
FL
Xiao
Min
M
Gao
Yong
Y
Cui
Jian-Jun
JJ
Chen
Xing
X
Fan
Liang-Dan
LD
Sun
Qing
Q
Xia
Kai-Yue
KY
Zhang
Zhen-Min
ZM
Niu
Shi-Jie
SJ
Xu
Andreas
A
Tzschach
Hilger
H
Ropers
Wei
W
Huang
Jian-Jun
JJ
Liu
D000328:Adult; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D016366:Open Reading Frames; D010375:Pedigree; D011565:Psoriasis / Q000235:genetics*
D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase