A factorial trial including garlic supplements assesses effect in reducing precancerous gastric lesions.
The Shandong Intervention Trial was a factorial, double-blind, placebo-controlled trial to determine whether any of 3 interventions, alone or in combination, could reduce the prevalence of precancerous gastric lesions in Linqu County, Shandong Province, China, a region with high gastric cancer mortality rates and a prevalence in adults of Helicobacter pylori of approximately 67%. The 3 interventions were one-time treatment with amoxicillin and omeprazole for Helicobacter pylori infection, and long-term administration of a garlic supplement (aged garlic extract and steam-distilled garlic oil) and a vitamin supplement (vitamins E and C and selenium). This paper describes the design and initial findings on treatment compliance, completeness of follow-up data, and eradication of Helicobacter pylori.
Gail
Mitchell H
MH
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. gailm@mail.nih.gov
You
Wei-Cheng
WC
D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002681:China; D019587:Dietary Supplements; D005163:Factor Analysis, Statistical; D005737:Garlic; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008903:Minerals; D010349:Patient Compliance; D008517:Phytotherapy; D011230:Precancerous Conditions / Q000453:epidemiology / Q000517:prevention & control*; D015995:Prevalence; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D014815:Vitamins
D000900:Anti-Bacterial Agents; D008903:Minerals; D014815:Vitamins; D000658:Amoxicillin