Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge.
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.
Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21702-5001, USA.
Sylvia R
SR
Treviño
Amy R
AR
Permenter
Marilyn J
MJ
England
Narayanan
N
Parthasarathy
Paul H
PH
Gibbs
David M
DM
Waag
Tran C
TC
Chanh
D000336:Aerosols; D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D042726:Burkholderia mallei / Q000276:immunology*; D005896:Glanders / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C
D000336:Aerosols; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal