Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.
Three new free radical scavengers were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compound davallialactone. Their structures were established as hispidin analogs by extensive NMR spectral data. Compounds 3 and 4 displayed significant scavenging activity against the superoxide radical anion, ABTS radical cation, and DPPH radical, while 1 and 2 exhibited potent antioxidative activity only against ABTS radical cation.
Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-333, Republic of Korea.
In-Kyoung
IK
Lee
Bong-Sik
BS
Yun
D000363:Agaricales / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002412:Cations / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D010851:Picrates / Q000037:antagonists & inhibitors / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification; D012015:Reference Standards; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000037:antagonists & inhibitors / Q000737:chemistry; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000737:chemistry
D000838:Anions; D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002412:Cations; D016166:Free Radical Scavengers; D005609:Free Radicals; D010851:Picrates; D011753:Pyrones; D013451:Sulfonic Acids; D013481:Superoxides; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C007946:hispidin