[Recurrent acute pancreatitis during pravastatin-therapy].
Acute pancreatitis can rarely be caused also by drugs. Several substances from different drug classes have been associated with the occurrence of acute pancreatitis. Regarding the class of the hydroxymethylglutaryl-CoA-reductase-inhibitors (statins) case-reports have been published in the literature in association with each individual statin. We present a 60-years-old male who developed twice an acute pancreatitis while being treated with pravastatin. Because some case reports describe the reoccurrence of acute pancreatitis after exposure to a different statin, recommendations for further therapy remain complex. There are also case reports of pancreatitis associated with fibrates and information on rare adverse reactions associated with ezetimibe is sparse.
Klinische Pharmakologie und Toxikologie, Universitätsspital Basel. beckerc@uhbs.ch
C
C
Becker
C
C
Hvalic
G
G
Delmore
S
S
Krähenbühl
R
R
Schlienger
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis; D017035:Pravastatin / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D013997:Time Factors
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin