Synthesis of gamma,delta-unsaturated-beta-keto lactones via sequential cross metathesis-lactonization: a facile entry to macrolide antibiotic (-)-A26771B.
A simple access to gamma,delta-unsaturated-beta-keto lactones is presented, allowing a rapid total synthesis of the naturally occurring 16-membered macrolide antibiotic (-)-A26771B via cross metathesis, asymmetric dihydroxylation, and lactonization as the key steps.
Institut für Chemie, Technische Universität Berlin, Strasse des 17, Juni 135, D-10623 Berlin, Germany.
Julian
J
Gebauer
Siegfried
S
Blechert
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D007783:Lactones / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; C014929:A26771B