Current evidence for a genetic modulation of the response to analgesics.
Lötsch
Jörn
J
pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, D-60590 Frankfurt, Germany. j.loetsch@em.uni-frankfurt.de
Geisslinger
Gerd
G
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D002394:Catechol O-Methyltransferase / Q000235:genetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic / Q000235:genetics; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics; D017450:Receptors, Opioid, mu / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000700:Analgesics; D044102:Receptor, Melanocortin, Type 1; D017450:Receptors, Opioid, mu; D019389:Cytochrome P-450 CYP2D6; D002394:Catechol O-Methyltransferase