Regression analysis of pesticide use and breast cancer incidence in California Latinas.
An evaluation of pesticide use data and breast cancer incidence rates in California Hispanic females was conducted via a regression analysis. The analysis used 1988-2000 data from the California Cancer Registry, the population-based cancer registry that monitors cancer incidence and mortality in California. It also used pesticide use data from 1970-1988 from the California Department of Pesticide Regulation. California is the leading agricultural state in the United States, and more than a quarter of all pesticides in the United States are applied there. Hispanic (Latina) females are commonly employed in agricultural operations. The authors performed regression analysis of county-level specific pesticide use data (pounds of active ingredients applied) for two classes of pesticides, organochlorines and triazine herbicides, against the breast cancer incidence rates among Latinas, controlling for age, socioeconomic status, and fertility rates, using negative binomial regression models. A total of 23,513 Latinas were diagnosed with breast cancer in California during the years 1988-1999. Risk of breast cancer was positively and significantly associated with age and socioeconomic status, and inversely and significantly associated with fertility levels. With respect to pesticides, breast cancer was positively associated with pounds of the organochlorines methoxychlor (adjusted incidence rate ratio [IRR] for highest quartile = 1.18; confidence interval [CI] = 1.03-1.35) and toxaphene (IRR = 1.16; CI = 1.01-1.34). No significant associations were found for the triazine herbicides atrazine and simazine.
Cancer Registry of Central California, Fresno 93710, USA. paul.mills@fresno.ucsf.edu
Paul K
PK
Mills
Richard
R
Yang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000383:Agriculture; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D002140:California / Q000453:epidemiology; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D016273:Occupational Exposure; D010575:Pesticides / Q000506:poisoning*; D012042:Registries / Q000706:statistics & numerical data*; D012044:Regression Analysis
D010575:Pesticides