Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma.
OBJECTIVE
To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.


METHODS
A prospective randomized, double-blind, placebo controlled, crossover study.


METHODS
In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.


RESULTS
The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.


CONCLUSIONS
The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.
The Rotterdam Eye Hospital, PO Box 70030, 3000 LM Rotterdam, The Netherlands. Ugahary@oogziekenhuis.nl
Luana Cahya
LC
Ugahary
Elisabeth
E
Ganteris
Marc
M
Veckeneer
Adam C
AC
Cohen
Jan
J
Jansen
Paul G H
PG
Mulder
Jan C
JC
van Meurs
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D018592:Cross-Over Studies; D003846:Deoxyepinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D015807:Eye Injuries, Penetrating / Q000150:complications*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D015814:Ocular Hypotension / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014605:Uveitis / Q000150:complications*; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects*
D018491:Dopamine Agonists; C023487:ibopamine; D003846:Deoxyepinephrine