Combined low volume polyethylene glycol solution plus stimulant laxatives versus standard volume polyethylene glycol solution: a prospective, randomized study of colon cleansing before colonoscopy.
BACKGROUND
The effectiveness of polyethylene glycol solutions (PEG) for colon cleansing is often limited by the inability of patients to drink adequate portions of the 4 L solution. The aim of the present study was to determine whether a reduced volume of PEG combined with stimulant laxatives would be better tolerated and as or more effective than the standard dose.


METHODS
Patients undergoing outpatient colonoscopy were randomly assigned to receive either low-volume PEG plus sennosides (120 mg oral sennosides syrup followed by 2 L PEG) or the standard volume preparation (4 L PEG). The subjects rated the tolerability of the preparations and their symptoms. Colonoscopists were blind to the colonic cleansing preparation and graded the cleansing efficacy using a validated tool (the Ottawa scale).


RESULTS
The low-volume PEG plus sennosides preparation was significantly better tolerated than the standard large volume PEG (P<0.001) but was less efficacious (P=0.03). Thirty-eight per cent of patients in the large volume PEG group were unable to finish the preparation, compared with only 6% in the reduced volume group. There were no adverse events reported.


CONCLUSIONS
Although the low-volume PEG plus sennosides preparation was better tolerated, it was not as effective as standard large-volume PEG. However, in view of the significant difference in tolerance, further research investigating possible improvements in the reduced-volume regimen seems warranted.
Hookey
Lawrence C
LC
Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario. lawrencehookey@yahoo.ca
Depew
William T
WT
Vanner
Stephen J
SJ
D000880:Anthraquinones / Q000008:administration & dosage*; D002400:Cathartics / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011446:Prospective Studies; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D002400:Cathartics; D004338:Drug Combinations; D000081226:Sennosides; D011092:Polyethylene Glycols; D012676:Senna Extract