Targeting HSP90 to halt neurodegeneration.
Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .
Gallo
Kathleen A
KA
Department of Physiology, Michigan State University, East Lansing, 48824, USA.
D000818:Animals; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D018841:HSP90 Heat-Shock Proteins / Q000187:drug effects*; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D015398:Signal Transduction; D013449:Sulfonamides / Q000494:pharmacology*; D013830:Thiadiazoles / Q000494:pharmacology*
C511717:AEG 3482; D004791:Enzyme Inhibitors; D018841:HSP90 Heat-Shock Proteins; D018696:Neuroprotective Agents; D013449:Sulfonamides; D013830:Thiadiazoles; D048031:JNK Mitogen-Activated Protein Kinases