Simple highly modular acyclic amine-catalyzed direct enantioselective addition of ketones to nitro-olefins.
Simple, highly modular primary amino acid derivatives catalyze the direct enantioselective addition of ketones to nitro-olefins with high stereocontrol and furnish the corresponding aldol products in high yield with up to >38 1 dr and up to 99% ee.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Yongmei
Y
Xu
Armando
A
Córdova