Hepatoprotective studies on Hedyotis corymbosa (L.) Lam.
Hedyotis corymbosa is used in traditional medicine of India and China to treat various hepatic disorders. In the present study, the hepatoprotective effect of the methanolic extract of the whole plant of Hedyotis corymbosa against paracetamol overdose-induced liver damage in Wistar rats was studied. The methanolic extract of the plant produced significant hepatoprotective effects as evidenced by decreased serum enzyme activities, SGPT, SGOT, SAKP and serum bilirubin and an almost normal histological architecture of the liver, in treated groups, compared to the controls. Hedyotis corymbosa shortened hexobarbitone-induced sleeping time in mice, besides showing significant antilipid peroxidant effect in vitro. The results thus support the use of Hedyotis corymbosa as a hepatoprotective agent.
Department of Biotechnology, Karpagam Arts and Science College, Coimbatore 641 021, India.
Sini
S
Sadasivan
P G
PG
Latha
J M
JM
Sasikumar
S
S
Rajashekaran
S
S
Shyamal
V J
VJ
Shine
D000082:Acetaminophen / Q000008:administration & dosage; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D032064:Hedyotis; D006591:Hexobarbital / Q000008:administration & dosage; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D018712:Analgesics, Non-Narcotic; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D020011:Protective Agents; D012838:Silymarin; D000082:Acetaminophen; D006591:Hexobarbital