[Changes in the outer mitochondrial membranes during apoptosis].
Mitochondria are involved in many apoptotic responses. Following permeabilization of their outer membrane, they release many apoptogenic proteins, including cytochrome c, which contribute to caspase activation. The mechanisms responsible for membrane permeability are not completely understood. Here, we briefly review the mechanisms that have been proposed to explain this phenomenon.
Département de biologie cellulaire, Université de Genève, 30, quai Ernest-Ansermet, 1211 Genève 4, Suisse.
Safa
S
Lucken-Ardjomande
Sylvie
S
Montessuit
Jean-Claude
JC
Martinou
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000145:classification / Q000235:genetics / Q000502:physiology*; D007425:Intracellular Membranes / Q000502:physiology* / Q000648:ultrastructure; D008928:Mitochondria / Q000502:physiology*; D005810:Multigene Family; D010539:Permeability; D021381:Protein Transport; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D019253:Proto-Oncogene Proteins c-bcl-2