Froc: a new fluorous protective group for peptide and oligosaccharide synthesis.
The synthesis of a new fluorous protecting group, Froc, is described. This new fluorous tag has been used in peptide and carbohydrate synthesis by our group and readily allows us to fully characterize each product (NMR, MS) and monitor each synthetic step by TLC. Purification of the products is generally performed by standard fluorous solid-phase extraction techniques (e.g., F-SPE), but standard chromatographic purifications are also possible if required.
C.N.R. - Istituto di Scienze e Tecnologie Molecolari (ISTM) and Centro Interdisciplinare Studi Biomolecolari e applicazioni Industriali (CISI), Via Venezian 21, I-20133 Milano, Italy. leonardo.manzoni@istm.cnr.it
Leonardo
L
Manzoni
Riccardo
R
Castelli
D002855:Chromatography, Thin Layer; D005461:Fluorine / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D013058:Mass Spectrometry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis*
D006846:Hydrocarbons, Halogenated; D009844:Oligosaccharides; D010455:Peptides; D005461:Fluorine