Activity of telithromycin against thirteen new isolates of C. burnetii including three resistant to doxycycline.
In this study we have evaluated the in vitro activity of antibiotics against 13 new isolates of Coxiella burnetii using a real-time quantitative PCR assay. MICs against doxycycline ranged from 1 to 8 microg/mL, telithromycin from 0.5 to 2 microg/mL, and all strains had MICs > or = 8 microg/mL for erythromycin. We report that strains resistant to doxycycline exist either in humans or animals.
Unité des rickettsies, CNRS UMR 6020, Université de la Méditerranée, Faculté de medicine, 13385 Marseille cedex 5, France.
Jean-Marc
JM
Rolain
Frédéric
F
Lambert
Didier
D
Raoult
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016997:Coxiella burnetii / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011778:Q Fever / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D048628:Ketolides; C106791:telithromycin; D004318:Doxycycline