Versatile precursors of functional RAFT agents. Application to the synthesis of bio-related end-functionalized polymers.
Biomolecule-polymer conjugates are widely used in bio-related fields, but their synthesis is often tricky, especially the introduction of a single biomolecule at one chain end. This paper describes a new straightforward approach to prepare such conjugates via RAFT polymerization. By designing appropriate bio-related RAFT agents, polymer chains of controlled chain length (Mn = 10 000-40 000 and PDI < 1.1) carrying a single biomolecule as an alpha-end group (a sugar or a biotin) linked by a stable amide bond are obtained. Considering the versatility of the RAFT process, this strategy appears to be very attractive for the design of a variety of conjugates.
Unité Mixte CNRS-bioMérieux, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, France.
Maël
M
Bathfield
Franck
F
D'Agosto
Roger
R
Spitz
Marie-Thérèse
MT
Charreyre
Thierry
T
Delair
D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002850:Chromatography, Gel; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry
D000180:Acrylic Resins; D001672:Biocompatible Materials; D009025:Morpholines; D013388:Succinimides; C015460:poly(acryloylmorpholine)