Secalonic acid D; A cytotoxic constituent from marine lichen-derived fungus Gliocladium sp. T31.
Secalonic acid D (SAD) was isolated as the major secondary metabolite of the marine lichen-derived fungus Gliocladium sp. T31. Its structure was established on the basic of physico-chemical and spectroscopic data. This is the first report on the isolation of SAD from this fungus, as well as its inhibitory effect on K562 cell cycle and its cytotoxicity against several tumor cell lines in vitro.
Key Laboratory of Marine Drug Chinese Ministry of Education, Institute of Marine Drug and Food, Ocean University of China, Qingdao 266003, China.
Hong
H
Ren
Li
L
Tian
Qianqun
Q
Gu
Weiming
W
Zhu
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002853:Chromatography, Liquid; D053938:DNA Fragmentation / Q000187:drug effects; D020462:Gliocladium / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D044004:Xanthones; C009218:secalonic acid; C022616:thiazolyl blue