Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish.
The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.
Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA.
Patoula G
PG
Panagos
Kimberly P
KP
Dobrinski
Xianghong
X
Chen
Amanda W
AW
Grant
David
D
Traver
Julie Y
JY
Djeu
Sheng
S
Wei
Jeffrey A
JA
Yoder
D000595:Amino Acid Sequence; D000818:Animals; D002470:Cell Survival / Q000502:physiology; D002875:Chromosomes; D022202:Chromosomes, Artificial, Bacterial; D007694:Killer Cells, Natural / Q000378:metabolism; D037181:Lectins, C-Type / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D008214:Lymphocytes / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D022423:Myeloid Cells / Q000378:metabolism*; D010802:Phylogeny; D015027:Zebrafish / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics* / Q000378:metabolism*
C511064:Illr1 protein, zebrafish; C511065:Illr3 protein, zebrafish; C511066:Illr4 protein, zebrafish; D037181:Lectins, C-Type; D029961:Zebrafish Proteins