Contribution of inflammation to lung injury and development.
Inflammation interferes with lung development in model systems and is present chronically in the lungs of preterm infants who develop bronchopulmonary dysplasia (BPD). Antenatal inflammation is very commonly associated with preterm deliveries, but there is generally minimal information about the duration, intensity, or organisms associated with chorioamnionitis. In preterm lamb models, chorioamnionitis causes a lung injury similar to BPD and also causes clinical lung maturation. Continuous exposure of the developing lung before and after delivery to inflammation may be central to the development of BPD.
Cincinnati Children's Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229-3039, USA. Suhas.Kallapur@cchmc.org
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D000818:Animals; D001997:Bronchopulmonary Dysplasia / Q000209:etiology*; D002821:Chorioamnionitis / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007249:Inflammation / Q000150:complications*; D008168:Lung / Q000196:embryology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012121:Respiration, Artificial / Q000009:adverse effects; D012756:Sheep