Is homocysteine an iron-dependent cardiovascular risk factor?
Recent studies of endothelial function suggest that adverse vascular effects of homocysteine are iron-dependent. Iron sucrose worsens and iron chelation eliminates homocysteine-associated decreases in flow-mediated dialation. There may be no vasculopathic effect of homocysteine without available reactive iron. Iron-dependent amplification of the vascular effects of homocysteine may be one of several mechanisms by which stored iron increases cardiac risk.
Sullivan
J L
JL
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA. jlsullivan@pol.net
D000328:Adult; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002614:Chelating Agents / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D005293:Ferritins; D006710:Homocysteine / Q000097:blood / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D000090463:Iron Deficiencies; D008297:Male; D008715:Methionine / Q000494:pharmacology / Q000502:physiology; D018384:Oxidative Stress; D011929:Razoxane / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012307:Risk Factors; D012727:Sex Characteristics; D014664:Vasodilation / Q000187:drug effects
D002614:Chelating Agents; D006710:Homocysteine; D011929:Razoxane; D005293:Ferritins; D008715:Methionine; D007501:Iron