Isoquinoline derivatives as potential acetylcholinesterase inhibitors.
Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.
Markmee
Sutthatip
S
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Ruchirawat
Somsak
S
Prachyawarakorn
Vilailak
V
Ingkaninan
Kornkanok
K
Khorana
Nantaka
N
D000110:Acetylcholinesterase / Q000378:metabolism*; D000470:Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D044182:Benzylisoquinolines / Q000138:chemical synthesis / Q000494:pharmacology; D001665:Binding Sites; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D003124:Colorimetry; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000470:Alkaloids; D044182:Benzylisoquinolines; D002800:Cholinesterase Inhibitors; D007546:Isoquinolines; D000110:Acetylcholinesterase