A comparison of the electron ionization and electrospray behaviour of some N,N'-disubstituted hexahydropyrimidines.
The behaviour of some N,N'-disubstituted hexahydropyrimidines, a class of naturally occurring compounds of biological and biomedical interest, has been studied in both electron ionization (EI) and electrospray ionization (ESI) modes coupled with collisional experiments (ESI-MSn). In both techniques, the [M-H]+ ions are highly abundant, even if their formation is generated by two different mechanisms, i.e. H. loss from the M+. species in the case of EI and hydride (H-) abstraction from the molecules in the case of ESI. Furthermore, due to the low, step-by-step internal energy deposition typical of collisional experiments performed in an ion trap mass spectrometer, different fragment ions were observed in EI and ESI-MSn collisions. In both cases, the ions can be related to the original structure and allow us to identify the positions in which the different substituents are present.
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires. Junin 956, (1113) Buenos Aires, Argentina. lorelli@ffyb.uba.ar
Liliana R
LR
Orelli
María B
MB
García
Isabel A
IA
Perillo
Loris
L
Tonidandel
Pietro
P
Traldi
D001688:Biological Products / Q000737:chemistry; D004583:Electrons; D007477:Ions / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D001688:Biological Products; D007477:Ions; D011355:Prodrugs; D011743:Pyrimidines