Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: mechanistic insight into lipoxygenase.
A simple additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with cumylperoxyl radical, which is expressed by the additive contributions of the reactivity of active hydrogens from the 1,4-pentadiene subunit and those of the allylic subunit; the kinetic isotope effect on the hydrogen transfer reactions (KIE = 6.1) is significantly smaller than that observed for lipoxygenase (KIE = 81).
Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Hironori
H
Kitaguchi
Kei
K
Ohkubo
Seiji
S
Ogo
Shunichi
S
Fukuzumi
D004578:Electron Spin Resonance Spectroscopy; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000378:metabolism*; D006859:Hydrogen / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008084:Lipoxygenase / Q000378:metabolism*; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry* / Q000378:metabolism*
D005231:Fatty Acids, Unsaturated; D010545:Peroxides; C049375:perhydroxyl radical; D006859:Hydrogen; D008084:Lipoxygenase