Method development for the determination of residual fluorotelomer raw materials and perflurooctanoate in fluorotelomer-based products by gas chromatography and liquid chromatography mass spectrometry.
The methodology for the determination of perfluorooctanoate (C(7)F(15)COO-, PFO), fluorotelomer alcohols (FTOHs: 6-2, 8-2, and 10-2), perfluorooctyl iodide (PFOI), and 8-2-8 fluorotelomer alcohol ester in complex fluorotelomer-based commercial products has been demonstrated and validated. Sample preparation procedures allowing determination of residual levels of these compounds were developed. The analytes were detected either by LC/MS/MS (PFO), LC/MS (FTOHs), or GC/MS (PFOI, 8-2-8 ester). The methods were validated by investigating the recoveries of analytes spiked at multiple levels to authentic sample matrices. The recoveries generally were between 70 and 130%. The limits of detection were in sub-microg/g range and the limits of quantitation were in the mug/g range. The methods were applied to fluorotelomer-based raw materials and fluorotelomer-based surfactants and polymeric products and represent methods useful for the determination of higher carbon chain length homologs as well.
DuPont Corporate Center for Analytical Sciences, Central Research and Development, Experimental Station, Wilmington, DE 19880, USA. barbara.s.larsen@usa.dupont.com
Barbara S
BS
Larsen
Peter
P
Stchur
Bogdan
B
Szostek
Stanley F
SF
Bachmura
Raymond C
RC
Rowand
Keith B
KB
Prickett
Stephen H
SH
Korzeniowski
Robert C
RC
Buck
D000438:Alcohols / Q000032:analysis; D002210:Caprylates / Q000032:analysis*; D002244:Carbon / Q000737:chemistry; D002849:Chromatography, Gas / Q000379:methods*; D004952:Esters / Q000032:analysis; D005233:Fatty Alcohols / Q000032:analysis; D005466:Fluorocarbons / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006847:Hydrocarbons, Iodinated / Q000032:analysis; D011108:Polymers / Q000032:analysis*; D013501:Surface-Active Agents / Q000032:analysis*
C505284:1,1,2,2-tetrahydroheptadecafluorodecanol-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol; D000438:Alcohols; D002210:Caprylates; D004952:Esters; D005233:Fatty Alcohols; D005466:Fluorocarbons; D006847:Hydrocarbons, Iodinated; D011108:Polymers; D013501:Surface-Active Agents; D002244:Carbon; C023036:perfluorooctanoic acid