Proteasome and transcription: a destroyer goes into construction.
The proteasome is a proteolytic complex that is known to degrade proteins marked by the attachment of ubiquitin. Recently, it has become apparent that the proteasome has non-proteolytic roles. Several studies have implicated the proteasome in the regulation of transcription. A new study now shows that the proteasome facilitates the interaction of a histone acetyltransferase complex with transcriptional activators at active promoters.
Hegde
Ashok N
AN
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. ahegde@wfubmc.edu
Upadhya
Sudarshan C
SC
D051548:Histone Acetyltransferases / Q000378:metabolism; D011401:Promoter Regions, Genetic; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D021122:Protein Subunits / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014158:Transcription, Genetic
D021122:Protein Subunits; D015534:Trans-Activators; D051548:Histone Acetyltransferases; D046988:Proteasome Endopeptidase Complex