The cognitive profile of posterior cortical atrophy.
BACKGROUND
Posterior cortical atrophy (PCA) is a progressive dementia characterized by prominent disorders of higher visual processing, affecting both dorsal and ventral streams to cause Balint's syndrome, alexia, and visual agnosia.


OBJECTIVE
To define the cognitive profile of PCA and compare to the typical, primary amnestic dementia of the Alzheimer's type (DAT).


METHODS
The authors used standard cognitive tests and a novel battery designed to reflect dysfunction in both ventral (Object, Face & Color Agnosia Screen [OFCAS]) and dorsal (complex pictures and compound stimuli) visual streams. The authors identified 19 patients with PCA and compared their performance to a matched group of patients with DAT and normal controls.


RESULTS
Patients with PCA were younger with marked impairment in visuospatial tasks, reading, and writing but relative preservation of memory compared to DAT using standard tests. Dorsal stream signs were most prevalent among the patients with PCA with no pure ventral stream syndromes found. All novel tests distinguished reliably between subjects with complex picture descriptions and processing of compound stimuli showing the most significant differences compared to DAT.


CONCLUSIONS
PCA is predominantly a dorsal stream syndrome, distinct from typical DAT, which involves occipitotemporal regions over time.
Department of Cognitive Neurology, University of Western Ontario, St. Joseph's Hospital, London, Ontario, N6A 4V2, Canada. paul.mcmonagle@sjhc.london.on.ca
Paul
P
McMonagle
Fiona
F
Deering
Yaniv
Y
Berliner
Andrew
A
Kertesz
D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000209:etiology; D000544:Alzheimer Disease / Q000523:psychology; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D020238:Prosopagnosia / Q000209:etiology