Herpes gestationis (Pemphigoid gestationis).
Herpes gestationis, coined by Milton in 1872, or gestational pemphigoid is the most clearly characterized dermatosis of pregnancy. It is a rare vesiculo-bullous eruption that develops during the last trimester or even postpartum and creates severe pruritus. Its etiology is unknown, but it is considered as an autoimmune-mediated dermatosis closely related to the pemphigoid group. Herpes gestationis is associated with a positive C3 deposition along the base of the epidermis in salt-split skin, with increased frequency of HLA-DR3 and also the combination DR3 and DR4. It has a high risk of prematurity and disappears in the postpartum period within weeks or months.
Al-Fouzan
Abdul-Wahab S
AW
Department of Dermatology, Al-Sabah Hospital, PO Box 1161, Safat-13002, Kuwait. alfouzan52@hotmail.com
Galadari
Ibrahim
I
Oumeish
Isam
I
Oumeish
Oumeish Y
OY
D005260:Female; D006801:Humans; D006559:Pemphigoid Gestationis / Q000503:physiopathology*; D011247:Pregnancy