Association between the scores on the general health questionnaire-28 and the saliva levels of 3-methoxy-4-hydroxyphenylglycol in normal volunteers.
To access the saliva level of 3-methoxy-4-hydroxy-phenylglycol (sMHPG) as an index of mental health in normal volunteers, we investigated the relationship between the sMHPG and the scores on the general health questionnaire-28 (GHQ-28). A total of 270 normal volunteers answered the GHQ-28 and the sMHPG levels were determined. The sMHPG levels in women and men were comparable. There was a significant negative correlation between the social dysfunction score on the GHQ-28 and sMHPG levels in women (P=0.0035), but not in men. Moreover, the sMHPG levels also correlated with the total GHQ-28 score (P=0.0205), the anxiety and the insomnia score (P=0.0306) in women. These data indicate a high social dysfunction score on the GHQ-28 to be associated with a reduced noradrenergic neuronal tone thus possibly reflecting psychomotor retardation in women.
Department of Neuropsychiatry, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Japan.
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Li
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Yamamoto
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Yamada
D000328:Adult; D000368:Aged; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology; D001143:Arousal / Q000502:physiology; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism*; D008875:Middle Aged; D009638:Norepinephrine / Q000502:physiology; D010555:Personality Inventory / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D011597:Psychomotor Performance / Q000502:physiology; D012016:Reference Values; D012463:Saliva / Q000378:metabolism*; D012737:Sex Factors; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology / Q000523:psychology; D012917:Social Adjustment; D013001:Somatoform Disorders / Q000503:physiopathology / Q000523:psychology; D013223:Statistics as Topic
D008734:Methoxyhydroxyphenylglycol; D009638:Norepinephrine