Experimental study on a large animal model of a new thermoablation technique.
BACKGROUND
A novel technique of thermoablation, using a microtube to deliver pulses of hot water vapour, was tested on a large animal model in order to evaluate its efficacy and potential adverse effects.


METHODS
The medical device consisted of a microtube extension connected to a hydropneumatic pump. Pulses of pure water were injected though the microtube where they were heated and delivered as vapour into the target zone. The method was tested on the liver of 12 healthy pigs, either during open surgery or percutaneously under ultrasounds.


RESULTS
The technique was efficient and well-tolerated by the animals. Large volumes of necrotic tissue were created in a significantly short time compared to concurrent thermoablative techniques.


CONCLUSIONS
Anticipating human application, this experimental study demonstrated a safe and efficient innovative thermoablation technique. The first human applications have been successfully performed and will be reported soon.
Centre d'Etudes et de Recherches Médicales d'Archamps, Domaine de Chosal, 74160 Archamps, France.
C
C
Roux
N
N
Rauber
E
E
Hiltbrand
J
J
Belenger
H
H
Khan
N
N
Dfouni
N
N
Michel
J F
JF
Knopf
J
J
Foray
H
H
Mehier
D000818:Animals; D002417:Cattle; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D007267:Injections / Q000295:instrumentation; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D023421:Models, Animal; D013552:Swine; D014463:Ultrasonography; D014835:Volatilization; D014867:Water
D014867:Water