Short-term exogenous glucocorticosteroidal effect on iron and copper status in canine leishmaniasis (Leishmania infantum).
Prednisolone was administered as an anti-inflammatory for 7 consecutive days in 11 dogs with leishmaniasis (CL group) and 5 clinically normal dogs (control group). After a 15-day wash-out phase, the same medication was given as an immunosuppressive for another 7-day period. In both animal groups and experimental periods an overall significant increase of serum iron and transferrin saturation was noted. Serum copper showed a significant increase during the anti-inflammatory period in the control group and a significant decrease during the immunosuppressive period in the CL group. No differences or changes of any kind regarding bone marrow hemosiderin were found between the 2 groups either before or after the end of both experimental periods. The only change noticed in the hematocrit values was a significant decrease in the control group after the end of the anti-inflammatory period. Based on these findings the use of prednisolone cannot be recommended and, if contemplated, should be carefully monitored, especially at an immunosuppressive dosage, because it may promote parasite replication through the induction of increased serum iron levels and hypocupremia.
Adamama-Moraitou
K K
KK
Clinic of Companion Animal Medicine, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Stavrou Voutyra 11, GR-54627 Thessaloniki, Greece. kadamama@vet.auth.gr
Saridomichelakis
M N
MN
Polizopoulou
Z
Z
Kritsepi
M
M
Tsompanakou
A
A
Koutinas
A F
AF
D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D003300:Copper / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood*; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation
D005938:Glucocorticoids; D006454:Hemoglobins; D003300:Copper; D011239:Prednisolone; D007501:Iron