Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: a three year prospective study.
OBJECTIVE
To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy.


METHODS
In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure.


RESULTS
A statistically significant reduction in mean arterial pressure was demonstrated (P < 0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P < 0.001). A critical decrease in oxygen saturation (< 90%) was documented in 27 patients (2.4%).


CONCLUSIONS
Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.
Department of Anesthesiology, Dubrava University Hospital, Zagreb, Croatia.
Stojanka
S
Gasparović
Nadan
N
Rustemović
Milorad
M
Opacić
Marina
M
Premuzić
Andelko
A
Korusić
Jadranka
J
Bozikov
Tamara
T
Bates
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D016292:Procedural Sedation; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies
D006993:Hypnotics and Sedatives; D010100:Oxygen; D015742:Propofol