Fatal central venous catheter-related infection in haemophilia.
Central venous catheters (CVC) are frequently used in children with haemophilia to deliver factor infusions for the treatment or prophylaxis of bleeding. Complications of CVCs in patients with haemophilia include thrombosis and infection. We report a young boy with severe haemophilia A and an inhibitor who developed disseminated Staphylococcus aureus infection most likely related to a CVC. To our knowledge, this is the first reported case of fatal sepsis secondary to a CVC in a patient with haemophilia.
Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9063, USA.
S E
SE
Crary
G R
GR
Buchanan
J M
JM
Journeycake
D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects / Q000382:microbiology; D003428:Cross Infection / Q000209:etiology*; D004866:Equipment Contamination; D005169:Factor VIII / Q000008:administration & dosage*; D017809:Fatal Outcome; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D013203:Staphylococcal Infections / Q000209:etiology*
D005169:Factor VIII