Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice.
The effect of gamma-linolenic acid (GLA) and prostaglandin E1 (PGE1) on gamma-radiation, diphenylhydantoin (DPH), benzo(a)pyrene (BP), and 4-alpha-phorbol-induced genetic damage to the bone marrow cells of mice, using the sensitive micronucleus (MN) test was investigated. PGE1 and its precursor GLA prevented gamma-radiation, DPH, BP, and 4-alpha-phorbol-induced genetic damage.
UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA. undurti@hotmail.com
Undurti N
UN
Das
Kaipa P
KP
Rao
D000527:Alprostadil / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001564:Benzo(a)pyrene / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects* / Q000528:radiation effects; D004900:Erythroblasts / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D010704:Phorbols / Q000494:pharmacology; D012156:Reticulocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D017965:gamma-Linolenic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D009153:Mutagens; D010704:Phorbols; D001564:Benzo(a)pyrene; D010672:Phenytoin; D017965:gamma-Linolenic Acid; D000527:Alprostadil; C033085:phorbol