Pathogenesis of liver involvement during dengue viral infections.
The dengue virus can infect many cell types and cause diverse clinical and pathological effects. We describe clinical and experimental observations that suggest that liver involvement occurs during dengue infections, and we outline the possible role played by host immune responses in this process.
Seneviratne
S L
SL
Department of Clinical Immunology, Level 7, John Radcliffe Hospital, Oxford OX3 9DU, UK. suran200@yahoo.co.uk
Malavige
G N
GN
de Silva
H J
HJ
D000410:Alanine Transaminase / Q000032:analysis; D017209:Apoptosis / Q000276:immunology; D001219:Aspartate Aminotransferases / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D003715:Dengue / Q000201:enzymology / Q000276:immunology / Q000821:virology*; D003716:Dengue Virus / Q000378:metabolism; D006529:Hepatomegaly / Q000821:virology; D006801:Humans; D007109:Immunity / Q000276:immunology; D008099:Liver / Q000201:enzymology / Q000276:immunology / Q000821:virology*; D008107:Liver Diseases / Q000201:enzymology / Q000276:immunology / Q000821:virology*; D013601:T-Lymphocytes / Q000276:immunology
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase