[Influence of antecedent of hypertension in patients with acute coronary syndrome without ST elevation].
OBJECTIVE
There are few studies evaluating the effect of a previous history of hypertension on long term prognosis after an acute coronary syndrome, using the new definitions and incorporating new risk markers in the analysis. The aim of our study was to determinate if hypertensive patients differ from non-hypertensives in the epidemiological profile, clinical presentation, treatment prescribed at discharge and prognosis after admission with non ST segment elevation acute coronary syndrome.


METHODS
A total of 1,029 consecutive patients admitted with high suspicion of non ST segment elevation acute coronary syndrome were evaluated. Prognostic variables were determined during admission (epidemiological and biochemical), as it was the discharge treatment. The primary endpoint was defined as all cause mortality at one year follow up.


RESULTS
65.8% (n = 677) of patients had hypertension. Hypertensive patients displayed a worst epidemiological and biochemical profile, and different discharge treatment. There were 139 (13.5%) deaths at one year follow up. The all cause mortality for non-hypertensive patients was 12.5% and for hypertensives 14.6% (p = NS). In the multivariate analysis (Cox regression) there were no differences in mortality between these groups.


CONCLUSIONS
A previous history of hypertension is an important factor to explain differences in the presence of other risk factors or the treatment, but is not a mortality predictor.
Fácila
Lorenzo
L
Servicio de Cardiología, Hospital Clínico Universitario, Valencia, Spain. lfacila@hotmail.com
Bertomeu
Vicente
V
Núñez
Julio
J
Sanchis
Juan
J
Bodí
Vicent
V
Consuegra
Luciano
L
Bosch
M José
MJ
Roselló
Araceli
A
Martínez
Angel
A
Blasco
María L
ML
Llàcer
Angel
A
D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology* / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors