Maternal aggression persists following lipopolysaccharide-induced activation of the immune system.
Lactating females direct aggressive behaviors towards intruders presumably to reduce the likelihood of infanticide of their pups. Infected animals display a constellation of responses that include lethargy, anorexia, and decreased social interactions. This suite of responses is referred to as sickness behavior, and is putatively part of an adaptive strategy to aid the organism in recovery from infection. Previous work has suggested that animals can suppress the behavioral symptoms of sickness in order to engage in adaptive behaviors. To test whether adaptive nest defense is affected by illness, dams received a peripheral injection of either saline or lipopolysaccharide (LPS [50, 400, or 1000 microg/kg]), a non-replicating component of bacterial cell walls that activates the immune system. Simulated infection with LPS reduced body mass and food intake in dams and interfered with litter growth in a dose-dependent manner. Generally, nest defense was unaffected by LPS; the proportion of dams displaying maternal aggression against a male intruder, as well as the latency and duration of aggressive encounters were only suppressed at the highest LPS dose tested. Further, LPS treatment also altered non-agonistic behavior during the aggression test as indicated by reduced social investigation of the intruder and an increased time spent immobile during the session. LPS administration also significantly increased serum corticosterone concentrations in lactating females. These findings suggest that maternal aggression is not suppressed by LPS-evoked immune activation at doses that attenuate other aspects of maternal and social behavior.
Departments of Neuroscience and Psychology, and Institute of Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA. Weil.20@osu.edu
Zachary M
ZM
Weil
Stephanie L
SL
Bowers
Eliot R
ER
Dow
Randy J
RJ
Nelson
D000222:Adaptation, Physiological / Q000276:immunology; D000374:Aggression / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D016009:Chi-Square Distribution; D003345:Corticosterone / Q000097:blood; D005260:Female; D007774:Lactation / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D008425:Maternal Behavior / Q000502:physiology*; D051379:Mice; D011897:Random Allocation; D011930:Reaction Time / Q000276:immunology*; D012803:Sick Role; D012919:Social Behavior; D018709:Statistics, Nonparametric
D008070:Lipopolysaccharides; D003345:Corticosterone