Evidence for instrument and family-specific variation of subclinical psychosis dimensions in the general population.
It is unknown to what degree dimensions of schizotypy (subclinical psychosis) show independent, family-specific variation in the general population. Psychologists administered the Community Assessment of Psychic Experiences, the Structured Interview for Schizotypy-Revised (SIS-R), and the Brief Psychiatric Rating Scale to 257 subjects pertaining to 82 general population families. All 3 instruments showed family-specific variation for positive and negative subclinical psychosis dimensions with between-families proportions of total variance between 10% and 40%. However, only the SIS-R showed family-specific variation of the negative dimension independent of its correlation with the positive dimension. The positive dimension of subclinical psychosis shows familial-specific variation in samples unselected for psychiatric disorder, suggesting dimensional liability in the population. The SIS-R additionally captures family-specific variation in the negative domain.
Hanssen
M
M
Department of Psychiatry and Neuropsychology, EURON, Maastricht University, Maastricht, The Netherlands.
Krabbendam
L
L
Vollema
M
M
Delespaul
P
P
Van Os
J
J
D000328:Adult; D000368:Aged; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011159:Population Surveillance / Q000379:methods*; D012494:Sampling Studies; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires