Gene therapy in cancer: the missing point.
Over the last century cancer research has produced data leading to a composite picture where gene mutations and epigenetic phenomena strictly relate and overlap. This complexity has repercussions on the anti-cancer therapeutical strategies. The therapeutic pathway paved by the kochian one-cause/one disease principle fails in front of a multigenic multiphenomena disease like cancer. We still do not know what target(s) to hit/modify in order to prevent/stop the carcinogenic progression. On the light of cancer statistics 2005, we discuss the need of exactly defining the cancer targets in order to exploit the high potential of gene therapy.
Kanduc
Darja
D
Department of Biochemistry and Molecular Biology, University of Bari, Italy. d.kanduc@biologia.uniba.it
Geliebter
Jan
J
Lucchese
Alberta
A
Mazzanti
Roberto
R
Mittelman
Abraham
A
Polimeno
Lorenzo
L
Ponzetto
Antonio
A
Santacroce
Raffaella
R
Simone
Simone
S
Sinigaglia
Eberta
E
Sinha
Animesh A
AA
Tessitore
Luciana
L
Tiwari
Raj K
RK
Farber
Emanuel
E
D002869:Chromosome Aberrations; D015316:Genetic Therapy; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000628:therapy*