Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development.
Trichinella spiralis creates a unique intracellular habitat in striated muscle. We report that a proteoglycan, syndecan-1, is induced early in infection yet is not essential for habitat development and exerts a modest influence on the immune response. This report is the first to address the requirement for a specific muscle protein in trichinellosis by using mice deficient in the relevant gene.
Beiting
Daniel P
DP
James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. db225@cornell.edu
Park
Pyong Woo
PW
Appleton
Judith A
JA
D000818:Animals; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D032342:Muscle Cells / Q000378:metabolism*; D024510:Muscle Development / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology*; D011509:Proteoglycans / Q000096:biosynthesis*; D053667:Syndecans; D017160:Trichinella spiralis / Q000502:physiology*; D014235:Trichinellosis / Q000378:metabolism* / Q000503:physiopathology
D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053667:Syndecans