Propensity of a circadian clock to adjust to the 24h day-night light cycle and its sensitivity to molecular noise.
The circadian clock of Drosophila melanogaster and its tendency to adjust to the day-night light cycle is simulated by deterministic and stochastic methods. The robustness of the locking to the light-cycle with respect to molecular noise is studied. It is found that within the model studied, the molecular noise in the stochastic simulation erases the finer injection-locking structures, stronger injection signals are needed and the locking has the character of prolonged locked time intervals with cycle slips in between. The simulations are compared to a simple injection-locking model with noise that seems to describe the overall behavior well.
Calander
Nils
N
Physics Department, Chalmers University of Technology, SE-412 96 Göteborg, Sweden. nils.calander@fy.chalmers.se
D000465:Algorithms; D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D008027:Light; D008954:Models, Biological; D013269:Stochastic Processes