The Leiden mutation and activated protein C resistance as risk factors for disseminated intravascular coagulation in acutely poisoned patients.
The aim of this work was to assess the prevalence of a genetic predisposition to disseminated intravascular coagulation (DIC) among acutely poisoned patients. Activated protein C resistence (APCR) is a genetically determined cause of thrombophilia and DIC development. One hundred seventy-six subjects were divided into three groups: one consisted of 83 acutely poisoned patients with DIC; a second consisted of 57 acutely poisoned patients without DIC; the third group consisted of 91 healthy controls. Abnormal results of APCR testing were found in 24.1% of the poisoned DIC group, 5.3% of the poisoned nonDIC group, and 3.3% of the control group. Genetic tests were performed in 37 selected patients. Factor V Leiden mutation (G/A genotype) was determined to be present in people whose R index value was below 1.9. These results raise the possibility that outcomes of acute poisonings may be influenced by genetic predisposition.
Prazanowski
Mirosław
M
Immunotoxicology Department Nofer Institute of Occupational Medicine in Lodz, Lodz, Poland.
Kur
Barbara
B
Barańska
Małgorzata
M
Lutz
Waldemar
W
Piłacik
Bozena
B
Kolaciński
Zbigniew
Z
D020016:Activated Protein C Resistance / Q000097:blood / Q000235:genetics*; D000208:Acute Disease; D000328:Adult; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D017354:Point Mutation; D011041:Poisoning / Q000097:blood / Q000235:genetics; D015995:Prevalence; D012307:Risk Factors; D015262:Xenobiotics / Q000506:poisoning*
D015262:Xenobiotics; C095381:factor V Leiden; D005165:Factor V