A tale of 2 alpha-herpesviruses: lessons for vaccinologists.
Of the 8 known herpesviruses that affect human beings, we only have successful vaccines against varicella zoster virus. This brief review compares the pathogenesis of varicella zoster virus with that of the closely related alpha-herpesviruses herpes simplex virus 1 and 2, for which we have no satisfactory vaccines. The main objective of this review is to learn lessons from the success of varicella zoster virus vaccine that could be exploited for the development of successful vaccines against herpes simplex virus and perhaps against other herpes viruses.
Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA. btr@utk.edu
Barry T
BT
Rouse
Shilpa Deshpande
SD
Kaistha
D002644:Chickenpox / Q000188:drug therapy / Q000517:prevention & control / Q000821:virology; D019433:Chickenpox Vaccine / Q000627:therapeutic use; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy / Q000517:prevention & control / Q000821:virology; D022301:Herpes Simplex Virus Vaccines / Q000627:therapeutic use; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D018258:Herpesvirus 2, Human / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D014645:Herpesvirus 3, Human / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D014764:Viral Proteins / Q000276:immunology; D014779:Virus Replication
D019433:Chickenpox Vaccine; D022301:Herpes Simplex Virus Vaccines; D014764:Viral Proteins