The incidence of recurrent herpes simplex and herpes zoster infection during treatment with arsenic trioxide.
We report the incidence of varicella zoster virus (VZV) and herpes simplex virus (HSV) infection in patients with multiple myeloma and colon cancer who were treated with arsenic trioxide for their disease. In this report, we discuss the effects of arsenic on immune system, and suggest arsenic compounds as a possible predisposing factor for viral reactivation in these patients.
Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida, USA. knouri@med.miami.edu
Keyvan
K
Nouri
Carlos A
CA
Ricotti
Navid
N
Bouzari
Halland
H
Chen
Eugene
E
Ahn
Ardalan
A
Bach
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000009:adverse effects* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy; D005260:Female; D006561:Herpes Simplex / Q000139:chemically induced* / Q000473:pathology; D006562:Herpes Zoster / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy; D010087:Oxides / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence
D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide