Kinetics of the appearance of cereal alkylresorcinols in pig plasma.
Alkylresorcinols (AR) are phenolic lipids found in high amounts in wholegrain wheat and rye. They may be important as bioactive components and/or biomarkers of wholegrain wheat and rye intake. AR absorption was studied with pigs during a habitual diet and after a single meal of AR-rich diet. In study 1, four pigs were fed wholegrain rye (RD) and white wheat bread (WD) for 1 week in a cross-over design. Arterial and venous AR concentrations were determined over 540 min after feeding on days 5 and 7. In study 2, four pigs were fed a synthetic, starch-based diet for 5 d, and arterial and venous AR concentrations were determined over 960 min after feeding a single meal of RD. In study 1, plasma AR concentrations after consuming RD peaked at 120 min, remained elevated between 120 and 420 min, and were re-elevated on refeeding at 480 min. In study 2, AR appeared in the plasma after 60 min, peaked at 180-240 min, and remained elevated after 960 min. The apparent elimination half-life was 3.93 h, and the maximum plasma concentration was 666 (sem 35) nmol/l. Arterial and venous plasma AR concentrations were similar, suggesting that AR are absorbed via the lymphatic system. AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5 d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake.
Linko
Anna-Maria
AM
Nestlé Research Centre, Lausanne 26, CH-1000, Switzerland. Anna.Linko@helsinki.fi
Ross
Alastair B
AB
Kamal-Eldin
Afaf
A
Serena
Anja
A
Kjaer
Anna Kirstin Bjørnbak
AK
Jørgensen
Henry
H
Peñalvo
José L
JL
Adlercreutz
Herman
H
Aman
Per
P
Knudsen
Knud Erik Bach
KE
D000821:Animal Feed; D000818:Animals; D019540:Area Under Curve; D015415:Biomarkers / Q000032:analysis; D018592:Cross-Over Studies; D002523:Edible Grain / Q000737:chemistry*; D006207:Half-Life; D008297:Male; D008638:Mesenteric Arteries; D023421:Models, Animal; D011169:Portal Vein; D012118:Resorcinols / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D012434:Secale; D013552:Swine; D014908:Triticum
D015415:Biomarkers; D012118:Resorcinols