[The effect of topical application of the local anesthetic (lidocaine) on the emergence from general anesthesia: the rat experimental model].
BACKGROUND
The current investigation was aimed on the effect of topical lidocaine application on the wound after back surgery and the emergence from general anesthesia in the rat.


METHODS
Each group (n = 14) consisted of male SD rats weighting 290 to 320 g. After oro-tracheal intubation and epidural catheter placement under sevoflurane anesthesia (2.8%), the animals were treated as follows; the first group: none, the second group: subcutaneous infiltration of 2% lidocaine 3 ml to the wound, and the third group: intraperitoneal injection of 2% lidocaine 3 ml. Then, the time was measured from the discontinuation of anesthetics to the appearance of eyelid reflex or body movement.


RESULTS
The time to eyelid reflex was 133.8 +/- 59.2, 160.2 +/- 52.0 and 152.8 +/- 68.5 sec (mean +/- SD), respectively. The time to body movement was 197.2 +/- 28.7, 247.1 +/- 46.7 and 220.2 +/- 39.1 sec, and a significant difference was found between first and the second group.


CONCLUSIONS
Topical application of local anesthetics prolonged the time to extubation without the delay for an appearance of eyelid reflex. The developed method using rats could be useful for future investigations of the nature of emergence from general anesthesia.
Intensive Care Unit of University Hospital, Hamamatsu University School of Medicine, Hamamatsu 431-3192.
Yushi
Y
Adachi
Kazuhiko
K
Watanabe
Maiko
M
Satomoto
Yoshiki
Y
Nakajima
Tomiei
T
Kazama
Matsuyuki
M
Doi
Shigehito
S
Sato
D000287:Administration, Topical; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000779:Anesthetics, Local; D008012:Lidocaine