Mannan-binding lectin in children with chronic gastritis.
The involvement of mannan-binding lectin (MBL) insufficiency in the pathogenesis of chronic gastritis (CG) in children was investigated. Blood samples were collected from 78 paediatric patients suffering from CG associated with Helicobacter pylori infection (group Hp(+)) and from 41 with the disease not associated with such an infection (group Hp(-)). Control group consisted of 77 children. The frequency of mbl-2 gene mutations and serum protein concentrations did not differ significantly in both groups as compared with controls. An expression of mbl-2 gene in gastric biopsies of CG patients was demonstrated. It was found to be stronger in H. pylori-infected children. The results presented in this paper suggest that MBL deficit/dysfunction probably does not contribute to an increased risk of CG (both associated and not associated with H. pylori infection) in children. However, MBL opsonic effect and/or the lectin pathway of complement activation may be taken into account as possible host defence mechanisms in gastric patients.
Bak-Romaniszyn
L
L
Department of Paediatrics, Preventive Cardiology and Clinical Immunology, Medical University of Łódź, Łódź, Poland.
Cedzyński
M
M
Szemraj
J
J
St Swierzko
A
A
Zeman
K
K
Kałuzyński
A
A
Płaneta-Małecka
I
I
D000293:Adolescent; D000483:Alleles; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005756:Gastritis / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D015870:Gene Expression; D005838:Genotype; D016481:Helicobacter Infections / Q000097:blood / Q000235:genetics / Q000276:immunology; D016480:Helicobacter pylori; D006801:Humans; D037601:Mannose-Binding Lectin / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA; D018709:Statistics, Nonparametric
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D004247:DNA