Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging.
We have developed a size series of unusually small, water-soluble (InAs)ZnSe (core)shell quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including multiple sequential lymph node mapping and extravasation from the vasculature. The biological utility of these fluorescent probes resulted from our intentional choice to match the semiconductor material and water-soluble ligand with a desired final hydrodynamic diameter and emission wavelength.
Zimmer
John P
JP
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA.
Kim
Sang-Wook
SW
Ohnishi
Shunsuke
S
Tanaka
Eichii
E
Frangioni
John V
JV
Bawendi
Moungi G
MG
D000818:Animals; D001152:Arsenicals / Q000737:chemistry*; D001798:Blood Proteins / Q000737:chemistry; D002104:Cadmium / Q000737:chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry; D007204:Indium / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011485:Protein Binding; D045663:Quantum Dots; D051381:Rats; D018036:Selenium Compounds / Q000737:chemistry*; D012666:Semiconductors; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry*
D001152:Arsenicals; D001798:Blood Proteins; D005456:Fluorescent Dyes; D018036:Selenium Compounds; D017967:Zinc Compounds; D002104:Cadmium; D007204:Indium; D011092:Polyethylene Glycols; D008063:Thioctic Acid; C015144:dihydrolipoic acid; C076773:indium arsenide; C044696:zinc selenide