[Effectiveness of immunoglobulin treatment in rats with experimental allergic encephalomyelitis].
The aim of our study was to investigate effectiveness ofintravenous immunoglobulin treatment at experimental allergic encephalomyelitis (EAE). EAE was induced by the administration of adult rat spinal cord homogenates with Freund's adjuvant. All rats were divided into three groups: the first group received intraperitoneal injections of human intravenous immunoglobulin in dose 0.5 g/kg from 12th to 16th day after induction of EAE; the second group received intraperitoneal injections of rat intravenous immunoglobulin in dose 0.5 g/kg from 12th to 15th day after induction of EAE; and the third group was a control group. We observed more rapid and full recovery from EAE in rats treated with intravenous immunoglobulin.
V O
VO
Mel'nyk
M I
MI
Lisianyĭ
L M
LM
Biel's'ka
S A
SA
Shniakin
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D051381:Rats; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D016756:Immunoglobulins, Intravenous