Linkage of lamins to fidelity of gene transcription.
Two major events are emerging as being involved in the fine regulatory mechanisms that control gene expression through the nuclear envelope/lamina. The first is the linkage of envelope proteins to transcription factors, most of which function as transcriptional repressors. The second is the interplay between nuclear lamina/nuclear envelope proteins and chromatin, through more or less direct interactions with DNA-binding proteins. The first mechanism appears to play a major role in tissue-specific functions, whereas the latter mechanism likely modifies higher-order chromatin organization, thus regulating differentiation and aging. This review highlights the importance of the study of a group of genetic diseases, collectively referred to as laminopathies, to understand the actual role played by lamins in ensuring the fidelity of gene expression and in modulating cell differentiation.
Maraldi
Nadir M
NM
ITOI-Consiglio Nazionale delle Richerche, Unit of Bologna, Via di Barbiano 1/10, c /o IOR-40136, Bologna, Italy. maraldi@area.bo.cnr.it
Lattanzi
Giovanna
G
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D008040:Genetic Linkage; D006801:Humans; D034882:Lamins / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D009685:Nuclear Envelope / Q000737:chemistry / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D034882:Lamins; D009687:Nuclear Proteins