[Serum fenitrothion concentration and toxic symptom in acute intoxication patients].
The serum drug concentrations were measured by HPLC or GC/MS in 15 patients of acute fenitrothion (MEP), an organophosphorus insecticide, intoxication. There was no fatal case. The patients were admitted 0.5 approximately 12 hours after the ingestion of 5 approximately 50g MEP. The range of serum MEP concentrations were from undetectable level (< 0.01 microg/mL) to 9.73 microg/mL. Toxic symptoms were correlated with the serum MEP levels. About < 7 microg/mL of the serum MEP levels associated with mild cases and about > 7 microg/mL associated with serious cases. The elimination curves in mild cases were successfully simulated by the one-compartment model and the elimination half-lives (T1/2) were 9.9 +/- 7.7hr (mean +/- S.D.). The serum MEP concentrations declined below the detectable level in 48hr. The elimination curves in two serious cases were successfully simulated by the two-compartment model. The T1/2 in the alpha phase were 5.3hr and 6.7hr (under the direct hemoperfusion), and the T1/2 in the beta phase were 35hr and 52hr. The serum MEP concentrations declined below the detectable level in 300hr.
National Cancer Center Hospital East Pharmacy Divison.
Kazuhiro
K
Koyama
Ryoh
R
Suzuki
Takaaki
T
Kikuno
Hirosi
H
Kaziwara
Tetuo
T
Shinba
D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005278:Fenitrothion / Q000097:blood* / Q000506:poisoning*; D008401:Gas Chromatography-Mass Spectrometry; D006207:Half-Life; D006801:Humans; D007306:Insecticides / Q000097:blood* / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012720:Severity of Illness Index; D013997:Time Factors
D015415:Biomarkers; D007306:Insecticides; D002802:Cholinesterases; D005278:Fenitrothion