Respiratory rhythm generation during gasping depends on persistent sodium current.
In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.
Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK. Julian.F.R.Paton@Bristol.ac.uk
Julian F R
JF
Paton
Ana P L
AP
Abdala
Hidehiko
H
Koizumi
Jeffrey C
JC
Smith
Walter M
WM
St-John
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology*; D001933:Brain Stem / Q000187:drug effects / Q000254:growth & development*; D000860:Hypoxia / Q000503:physiopathology; D001239:Inhalation / Q000187:drug effects / Q000502:physiology*; D009415:Nerve Net / Q000187:drug effects / Q000254:growth & development*; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D010507:Periodicity; D051381:Rats; D012125:Respiratory Center / Q000187:drug effects / Q000254:growth & development*; D026941:Sodium Channel Blockers / Q000494:pharmacology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D026941:Sodium Channel Blockers; D015222:Sodium Channels