Necrobiotic xanthogranuloma with paraproteinaemia.
Necrobiotic xanthogranuloma is a rare cutaneous condition that can be mistaken for atypical necrobiosis lipoidica. It has a strong association with a paraproteinaemia, which may progress to frank haematological malignancy. We describe four patients with variable cutaneous features, and their treatment response.
Department of Dermatology, Medway Maritime Hospital, Gillingham, Kent, UK. sandyflann@hotmail.com
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S
Flann
E M
EM
Wain
S
S
Halpern
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V
Andrews
S
S
Whittaker
D000368:Aged; D000369:Aged, 80 and over; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017441:Necrobiotic Disorders / Q000175:diagnosis* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D014973:Xanthomatosis / Q000175:diagnosis* / Q000188:drug therapy
D018906:Antineoplastic Agents, Alkylating; D013256:Steroids; D002699:Chlorambucil; D003520:Cyclophosphamide