Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.
Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1(-/-) mice were healthy, their wound healing was normal, and tumors grew normally when implanted in s.c. sites. However, there was a striking reduction in tumor growth, invasiveness, and metastasis after transplantation of tumors to abdominal sites in mice without functional Tem1 genes. These data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site. Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.
Nanda
Akash
A
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
Karim
Baktiar
B
Peng
Zhongsheng
Z
Liu
Guosheng
G
Qiu
Weiping
W
Gan
Christine
C
Vogelstein
Bert
B
St Croix
Brad
B
Kinzler
Kenneth W
KW
Huso
David L
DL
D000008:Abdominal Neoplasms / Q000098:blood supply / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C509258:tumor endothelial marker 1, mouse