Medial reorganization of motor function demonstrated by functional MRI and diffusion tensor tractography.
OBJECTIVE
Peri-lesional reorganization is a motor recovery mechanism after brain injury. The object of this study was to demonstrate the peri-lesional reorganization, using functional MRI (fMRI) and diffusion tensor tractography (DTT).


METHODS
Six control subjects and a 53 year-old woman with left primary sensori-motor cortex (SM1) and underlying deep white matter injury were evaluated. The patient presented with complete paralysis of the right hand after the resection of a meningioma on the left SM1. The motor function of the affected hand had recovered slowly the extent of her being able to overcome some resistance for 6 months. At 2 years after the operation, fMRI was performed at 1.5 T in parallel with timed finger flexion-extension movements in all subjects and DTT was performed only in the patient.


RESULTS
The contralateral SM1 centered on the precentral knob was activated during hand movements of unaffected (left) side or control subjects. However, the medial area of the injured SM1 was activated during affected (right) hand movements. DTT of the affected (left) hemisphere originated from the medial area of the injured SM1 and descended along the medial side of injured deep white matter.


CONCLUSIONS
It seems that the motor function of the affected hand was reorganized into the medial area of the injured SM1 and deep white matter in this patient.
Jang
Sung Ho
SH
Department of Physical Medicine and Rehabilitation, School of Medicine, Yeungnam University, Namku, Taegu, Republic of Korea. strokerehab@hanmail.net
Kwon
Yong-Hyun
YH
You
Sung H
SH
Song
Jun Chan
JC
Lee
Mi Young
MY
Kim
Joong Hwi
JH
Park
Kyung Hee
KH
Cho
Yoon Woo
YW
D000368:Aged; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000098:blood supply* / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D010291:Paresis / Q000473:pathology* / Q000503:physiopathology
D010100:Oxygen