Implications for CNS repair of redox modulation of cell survival, division and differentiation.
Studies on oligodendrocytes, the myelin-forming cells of the central nervous system, and on the progenitor cells from which they are derived, have provided several novel insights into the role of intracellular redox state in cell function. A central unifying theme of this research is that redox state modulation lies at the heart of understanding cell-intrinsic aspects of precursor cell function, responsiveness of precursor cells to cell-extrinsic signals and even the means by which cell-extrinsic signaling molecules alter cellular function. This review discusses our studies on the role in redox state as a critical modulator of cellular function, and considers the implications of these findings for optimizing tissue repair.
Noble
Mark
M
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA. mark_noble@urmc.rochester.edu
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D019070:Cell Lineage; D002470:Cell Survival / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology