Post-thrombotic syndrome is uncommon in childhood cancer survivors.
Deep vein thrombosis occurs in up to 50% of children with tunneled central venous catheters (CVCs). CVC-related deep vein thrombosis involving the upper extremity is usually asymptomatic but can result in post-thrombotic syndrome (swelling, pain, skin changes, and functional impairment). In a cohort of childhood cancer survivors evaluated clinically a mean of 7.5 +/- 2.8 years after completion of therapy who previously had CVCs in place for a median 15.5 months, none of 50 patients (95% CI = 0% to 6%) had these features diagnostic of post-thrombotic syndrome. Five patients had arm circumference 3% to 5% greater ipsilateral to the prior CVC.
Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA. janna.journeycake@childrens.com
Janna M
JM
Journeycake
Debra
D
Eshelman
George R
GR
Buchanan
D000293:Adolescent; D001132:Arm / Q000033:anatomy & histology; D002405:Catheterization, Central Venous / Q000009:adverse effects; D015331:Cohort Studies; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000628:therapy*; D011186:Postphlebitic Syndrome / Q000453:epidemiology*; D017741:Survivors; D013781:Texas / Q000453:epidemiology; D020246:Venous Thrombosis / Q000453:epidemiology