Study on the susceptibility of Sahel goats to experimental Trypanosoma vivax infection.
Sahel goats, also known as Borno whites are found in the northern semi-arid, tsetse free Sahel region of Nigeria. They are transported alongside cattle from this zone to all other zones in the country, including the tsetse-infested zones, for commercial purposes and are kept for some time in these tsetse-infested zones until they are sold. This study therefore assessed the susceptibility of this breed of goats to trypanosome infection and its response to treatment with Berenil. Six bucks were inoculated intravenously with Trypanosoma vivax through the jugular vein while two served as uninfected control. The mean pre-patent period was 4.5 days and increasing parasitaemia followed the establishment of infection. Onset of parasitaemia was associated with increase in rectal temperature in all the infected goats and the temperature peak coincided with the only parasitaemic peak second week post-infection. The infected goats were treated with Berenil (Hoechst, Germany) 3.5mg/kg body weight at 4 weeks post-infection. The packed cell volume (PCV) continued to fall from a mean 30.73+/-0.01% pre-infection to a mean 13.21+/-0.18% at 1 week post-treatment. Deaths were recorded for 4 of the infected goats 1 week post-treatment while the remaining two died 2 weeks post-treatment, not responding to treatment.
Akinwale
Olaoluwa P
OP
Public Health Division, Nigerian Institute of Medical Research, PMB2013 Yaba, Lagos, Nigeria. pheabian@yahoo.co.uk
Nock
Ishaya H
IH
Esievo
King A N
KA
Edeghere
Henry U
HU
Olukosi
Yetunde A
YA
D000818:Animals; D004133:Diminazene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004198:Disease Susceptibility; D015511:Goat Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D006041:Goats; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D018512:Parasitemia / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary; D011897:Random Allocation; D016896:Treatment Outcome; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D016689:Trypanosoma vivax / Q000472:pathogenicity*; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary*
D014344:Trypanocidal Agents; C003915:diminazene aceturate; D004133:Diminazene