Do recommended high-risk adults benefit from a first influenza vaccination?
It is unknown whether a first influenza vaccination protects high-risk adults from severe morbidity and mortality during influenza epidemics. As part of the PRISMA nested case-control study, we aimed to evaluate the effectiveness of first-time and repeat influenza vaccinations in adult persons recommended for vaccination aged between 18 and 64 years during the 1999-2000 influenza A epidemic. After adjustments, 69% of hospitalizations for acute respiratory or cardiovascular disease or death were prevented in first-time vaccinees (95% percent confidence interval [95% CI]: 8-90%). The corresponding figure in persons who were vaccinated before was 85% (95% CI: 36-96%). Adult persons with high-risk medical conditions can substantially benefit from a first and repeat influenza vaccination prior to an epidemic.
Julius Center for Health Sciences and Primary Health Care, University Medical Center Utrecht, HP 6.139, P.O. Box 85060, 3508 AB Utrecht, The Netherlands. e.hak@med.uu.nl
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Hak
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Buskens
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Nichol
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Verheij
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D004196:Disease Outbreaks / Q000517:prevention & control; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000150:complications / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000150:complications; D012307:Risk Factors
D007252:Influenza Vaccines