Modulation of emetic response by carotid baro- and chemoreceptor activations.
We hypothesized that baroreceptor or chemoreceptor activation might be involved in the emetic, and prodromal cardiovascular and respiratory responses. To test this hypothesis, we induced the emetic responses by gastric distension in anesthetized Suncus murinus (house musk shrew), that had intact and absent baroreceptor and chemoreceptor afferents. Secondly, we stimulated the aortic depressor nerve (ADN) and the carotid sinus nerve (CSN) with or without gastric distension. Internal carotid artery ligation in the bifurcation area, which abolished reflex bradycardia by baroreceptor activation, and abolition of chemoreceptor reflex bradycardia and hyperventilation, by carotid body denervation, suppressed the emetic response but did not abolish it. ADN denervation, which produced no significant effects on the baroreceptor or chemoreceptor reflex bradycardia, had no effect on the emetic response, including the prodromal phase. CSN stimulation with gastric distension elicited retching accompanied by reflex bradycardia and hypotension during or just after stimulation, whereas ADN stimulation with gastric distension did not induce the cardiovascular reflex, and had no effects on the emetic response. These results indicate that carotid, rather than aortic, baroreceptor or chemoreceptor activation plays an important role in the augmentation of cardiac parasympathetic activity and the development of emetic response. In conclusion, carotid baroreceptor or chemoreceptor activation, which is non-emetic stimulation, acts as a modulator in the central mechanisms of emesis.
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. aa27149@mail.ecc.u-tokyo.ac.jp
Masahiro
M
Uchino
Masayoshi
M
Kuwahara
Susumu
S
Ebukuro
Hirokazu
H
Tsubone
D000818:Animals; D031608:Area Postrema / Q000503:physiopathology; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001919:Bradycardia / Q000209:etiology / Q000503:physiopathology; D002344:Carotid Body / Q000033:anatomy & histology / Q000502:physiology*; D002346:Carotid Sinus / Q000294:innervation / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000033:anatomy & histology / Q000502:physiology*; D004558:Electric Stimulation; D006985:Hyperventilation / Q000503:physiopathology; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology; D008026:Ligation; D009041:Motion Sickness / Q000503:physiopathology; D011311:Pressoreceptors / Q000033:anatomy & histology / Q000502:physiology*; D012018:Reflex / Q000502:physiology; D012788:Shrews; D017552:Solitary Nucleus / Q000503:physiopathology; D013270:Stomach / Q000294:innervation / Q000503:physiopathology; D014630:Vagus Nerve / Q000033:anatomy & histology / Q000502:physiology; D014839:Vomiting / Q000503:physiopathology*