L-prolinamide-catalyzed direct nitroso aldol reactions of alpha-branched aldehydes: a distinct regioselectivity from that with L-proline.
The first direct enantioselective N-nitroso aldol reaction of aldehyde with nitrosobenzene catalyzed by an L-prolinamide derivative is presented; the reactions proceed smoothly furnishing the -hydroxyamino carbonyl compounds, the otherwise disfavored products, in good yields with up to 64% ee.
Key Laboratory for Asymmetric Sunthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemsitry, Chinese Academy of Sciences, Chengdu, 610041, China.
Hai-Ming
HM
Guo
Li
L
Cheng
Lin-Feng
LF
Cun
Liu-Zhu
LZ
Gong
Ai-Qiao
AQ
Mi
Yao-Zhong
YZ
Jiang