Distribution of C-reactive protein and its relation to arterial hypertension in a country representing a high-risk region for cardiovascular diseases.
OBJECTIVE
The high-sensitivity C-reactive protein (hs-CRP) measurement is recommended by ESC/ESH Guidelines 2003 in patients with arterial hypertension. The aim of this study was to assess distribution of hs-CRP in Poland, a country representing a high-risk region for CVD.


RESULTS
In 2002, the cross-sectional survey NATPOL PLUS was performed in a representative sample of adults in Poland aged 18-94 years. The questionnaire, anthropometrical and blood pressure measurements, glycaemia, lipidogram and hs-CRP were performed in 2333 respondents. The results of hs-CRP > 10 mg/l were excluded from analysis. Mean hs-CRP was 2.03+/-2.14 mg/l (2.13+/-2.12 mg/l in women vs 1.91+/-2.16 mg/l in men; p < 0.05). Hs-CRP > or = 1 mg/l was observed in 58% of women and in 52% of men (p < 0.05). In hypertensives (> or =140/90 mmHg or treatment: women 30% vs men 29%, ns.), hs-CRP > or = 1 mg/l was found in 74% of women, and in 63% of men. The transformed values of hs-CRP [-1/[hs-CRP](1/2)] were higher in hypertensive patients than in normotensives (-0.94 vs -1.05; p < 0.01).


CONCLUSIONS
(i) The increased level of hs-CRP was found in more than half of adults in Poland. (ii) The hs-CRP is higher in hypertensive patients than in normotensives. (iii) In view of the given results, routine measurements of hs-CRP in hypertensive patients in a country like Poland should be reconsidered.
Zdrojewski
Tomasz
T
Department of Hypertension and Diabetology, Medical University of Gdańsk, Poland. tzdroj@amg.gda.pl
Chwojnicki
Kamil
K
Bandosz
Piotr
P
Konarski
Roman
R
Wyrzykowski
Bogdan
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D019353:Endemic Diseases; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011044:Poland; D011237:Predictive Value of Tests; D012307:Risk Factors
D002097:C-Reactive Protein