The Leiden mutation and activated protein C resistance as risk factors for disseminated intravascular coagulation in acutely poisoned patients.
The aim of this work was to assess the prevalence of a genetic predisposition to disseminated intravascular coagulation (DIC) among acutely poisoned patients. Activated protein C resistence (APCR) is a genetically determined cause of thrombophilia and DIC development. One hundred seventy-six subjects were divided into three groups: one consisted of 83 acutely poisoned patients with DIC; a second consisted of 57 acutely poisoned patients without DIC; the third group consisted of 91 healthy controls. Abnormal results of APCR testing were found in 24.1% of the poisoned DIC group, 5.3% of the poisoned nonDIC group, and 3.3% of the control group. Genetic tests were performed in 37 selected patients. Factor V Leiden mutation (G/A genotype) was determined to be present in people whose R index value was below 1.9. These results raise the possibility that outcomes of acute poisonings may be influenced by genetic predisposition.
Immunotoxicology Department Nofer Institute of Occupational Medicine in Lodz, Lodz, Poland.
Mirosław
M
Prazanowski
Barbara
B
Kur
Małgorzata
M
Barańska
Waldemar
W
Lutz
Bozena
B
Piłacik
Zbigniew
Z
Kolaciński
D020016:Activated Protein C Resistance / Q000097:blood / Q000235:genetics*; D000208:Acute Disease; D000328:Adult; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D017354:Point Mutation; D011041:Poisoning / Q000097:blood / Q000235:genetics; D015995:Prevalence; D012307:Risk Factors; D015262:Xenobiotics / Q000506:poisoning*
D015262:Xenobiotics; C095381:factor V Leiden; D005165:Factor V