Dermal absorption and penetration of jet fuel components in humans.
Jet propulsion fuel 8 (JP-8) is the largest source of chemical exposures on military bases. Dermal exposure to JP-8 has been investigated in vitro using rat or pig skin, but not in vivo in humans. The purpose of this study was to investigate the absorption and penetration of aromatic and aliphatic components of JP-8 in humans. A surface area of 20 cm2 was delineated on the forearms of human volunteers and 1 ml of JP-8 was applied to the skin. Tape-strip samples were collected 30 min after application. Blood samples were taken before exposure (t=0 h), after exposure (t=0.5 h), and every 0.5 h for up to 4 h past exposure. The tape-strip samples showed evidence of uptake into the skin for all JP-8 components. The blood data was used to estimate an apparent permeability coefficient (Kp). The rank order of the apparent Kp was naphthalene>1-methyl naphthalene=2-methyl naphthalene>decane>dodecane>undecane. This rank order is similar to results from rat and pig-skin studies. However, this study demonstrates that rat and pig models of the skin over predict the internal dose of JP-8 components in humans.
Department of Environmental Sciences and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7431, United States.
David
D
Kim
Melvin E
ME
Andersen
Leena A
LA
Nylander-French
D000279:Administration, Cutaneous; D000328:Adult; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006838:Hydrocarbons / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
D006838:Hydrocarbons; C098607:JP8 aviation fuel