Prophylactic use of sustained-release doxycycline blocks tick-transmitted infection by Anaplasma phagocytophilum in a murine model.
A sustained-release formulation of doxycycline hyclate was tested for its ability to block Anaplasma phagocytophilum infection in mice. Mice treated with sustained-release doxycycline showed no splenomegaly and their blood samples were negative by PCR on days 7, 14, and 21. Control mice treated with either oral doxycycline or water had significant splenomegaly and were PCR positive at multiple time points. The sustained-release doxycycline formulation was shown to be efficacious for preventing tick-transmitted A. phagocytophilum infection in a mouse model.
Massung
Robert F
RF
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. rfm2@cdc.gov
Zeidner
Nordin S
NS
Dolan
Marc C
MC
Roellig
Dawn
D
Gabitzsch
Elizabeth
E
Troughton
Danielle R
DR
Levin
Michael L
ML
D041081:Anaplasma phagocytophilum / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003692:Delayed-Action Preparations / Q000494:pharmacology; D004195:Disease Models, Animal; D004199:Disease Vectors; D004318:Doxycycline / Q000494:pharmacology*; D016873:Ehrlichiosis / Q000517:prevention & control* / Q000635:transmission; D018884:Ixodes / Q000382:microbiology; D051379:Mice; D013154:Spleen / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004318:Doxycycline