Effect of Cardiospermum halicacabum on ethanol-induced gastric ulcers in rats.
Ethanol extract of Cardiospermum halicacabum Linn. (Sapindaceae), in a concentration dependant manner (200-600mg/kg) inhibited gastric ulcers induced by oral administration of absolute ethanol. Further, the extract administration to rats resulted in an increase in levels of gastric glutathione and a decrease in alkaline phosphatase activity. The extract also exhibited potent in vitro hydroxyl radical scavenging and inhibition of lipid peroxidation activities. The extract was found to be devoid of any conspicuous acute and short-term toxicity in rats.
Molecular Ethnopharmacology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.
M S
MS
Sheeba
V V
VV
Asha
D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002492:Central Nervous System Depressants / Q000633:toxicity; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D005978:Glutathione / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D029631:Sapindaceae / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D000431:Ethanol; D000469:Alkaline Phosphatase; D005978:Glutathione