A de novo subterminal trisomy 10p and monosomy 18q in a girl with MCA/MR: case report and review.
We report on a 3-year-old girl with psychomotor retardation, cardiopathy, strabismus, umbilical hernia, and facial dysmorphism in whom a de novo unbalanced submicroscopic translocation (10p;18q) was found by MLPA (Multiplex Ligation dependent Probe Amplification) and FISH analyses. Additional FISH studies with locus specific RP11 BAC probes and analyses with microsatellites revealed that the translocation resulted in a deletion estimated between 6 and 9 Mb on the maternal chromosome 18 and a subtelomeric 10p duplication of approximately 6.9 Mb. The proband's karyotype is 46,XX.ish der(18) t(10;18)(18pter-->18q23:10p15 --> 10pter). A subterminal duplication of 10p, as well as a subterminal deletion of 18q have been rarely reported so far. The clinical phenotype of this patient is reviewed and discussed.
Courtens
Winnie
W
Department of Medical Genetics, University Hospital Antwerp, Antwerp, Belgium. winnie.courtens@ua.ac.be
Wuyts
Wim
W
Scheers
Stefaan
S
Van Luijk
Rob
R
Reyniers
Edwin
E
Rooms
Liesbeth
L
Ceulemans
Berten
B
Kooy
Frank
F
Wauters
Jan
J
D000015:Abnormalities, Multiple / Q000235:genetics*; D000782:Aneuploidy; D002675:Child, Preschool; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008607:Intellectual Disability / Q000235:genetics*; D018895:Microsatellite Repeats; D021141:Nucleic Acid Amplification Techniques; D014178:Translocation, Genetic; D014314:Trisomy