Protective and destructive immunity in the periodontium: Part 2--T-cell-mediated immunity in the periodontium.
Based on the results of recent research in the field and Part 1 of this article (in this issue), the present paper will discuss the protective and destructive aspects of the T-cell-mediated adaptive immunity associated with the bacterial virulent factors or antigenic determinants during periodontal pathogenesis. Attention will be focused on: (i) osteoimmunology and periodontal disease; (ii) some molecular techniques developed and applied to identify critical microbial virulence factors or antigens associated with host immunity (with Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis as the model species); and (iii) summarizing the identified virulence factors/antigens associated with periodontal immunity. Thus, further understanding of the molecular mechanisms of the host's T-cell-mediated immune responses and the critical microbial antigens related to disease pathogenesis will facilitate the development of novel therapeutics or protocols for future periodontal treatments.
Laboratory of Molecular Microbial Immunity, Eastman Department of Dentistry, Eastman Dental Center, Box-683, 625 Elmwood Ave., Rochester, NY 14620, USA. andy_teng@urmc.rochester.edu
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D016976:Aggregatibacter actinomycetemcomitans / Q000472:pathogenicity; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D016723:Bone Remodeling / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D010510:Periodontal Diseases / Q000276:immunology* / Q000382:microbiology; D010519:Periodontium / Q000276:immunology*; D016966:Porphyromonas gingivalis / Q000472:pathogenicity; D013601:T-Lymphocytes / Q000276:immunology; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000276:immunology; D037521:Virulence Factors / Q000276:immunology
D000942:Antigens, Bacterial; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D037521:Virulence Factors