Role of dynamic sentinel node biopsy in penile cancer: our experience.
OBJECTIVE
We report our initial experience with a relatively new technique, the so-called "dynamic sentinel node biopsy", in patients with penile cancer.


METHODS
From January 2001 to February 2003, 17 consecutive patients with bilateral, clinically node negative penile cancer were enrolled. Dynamic sentinel node biopsy was followed by local excision of the primary lesion or penile amputation during the same session. Standard inguinal node dissection was performed 4 weeks after the first operation in all the patients.


RESULTS
Pre-operative lymphoscintigraphy revealed no sentinel nodes in 1, unilateral sentinel nodes in 5, and bilateral in 11 patients. Metastases were noted in 5 out of 16 patients (31.25%), bilaterally in 3 of them. Among the five patients with sentinel node metastasis, this was the only tumor positive lymph node in one patient. In all cases with negative dynamic sentinel node biopsy, no metastatic nodes were found at the following inguinal node dissection. Therefore, the technique showed a 100% negative predictive value and an 88% sensitivity.


CONCLUSIONS
We believe that dynamic sentinel node biopsy is a minimally invasive procedure that can be easily performed. The goal is to offer the possibility of less extensive surgery for selected low risk patients.
Perdonà
S
S
Department of Urology, IRCCS, National Cancer Institute, G. Pascale Foundation, Naples, Italy. s.perdona@libero.it
Autorino
R
R
Gallo
L
L
Di Lorenzo
G
G
Cascini
G L
GL
Lastoria
F
F
Marra
L
L
De Sio
M
M
Damiano
R
R
Gallo
A
A
D000368:Aged; D000671:Amputation, Surgical; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*