A possible role of exon-shuffling in the evolution of signal peptides of human proteins.
It was recently shown that there is a predominance of phase 1 introns near the cleavage site of signal peptides encoded by human genes. It was suggested that this biased distribution was due to intron insertion at AGmid R:G proto-splice sites. However, we found that there is no disproportional excess of AGmid R:G that would support insertion at proto-splice sites. In fact, all nGmid R:G sites are enriched in the vicinity of the cleavage site. Additional analyses support an alternative scenario in which exon-shuffling is largely responsible for such excess of phase 1 introns.
Vibranovski
Maria Dulcetti
MD
Laboratory of Computational Biology, Ludwig Institute for Cancer Research, Sao Paulo Branch, Rua Prof. Antonio Prudente 109, CEP 01509-010, São Paulo, SP, Brazil.
Sakabe
Noboru Jo
NJ
de Souza
Sandro José
SJ
D019143:Evolution, Molecular; D005091:Exons / Q000235:genetics*; D006801:Humans; D007438:Introns; D021382:Protein Sorting Signals / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D022821:RNA Splice Sites; D012326:RNA Splicing; D011995:Recombination, Genetic
D021382:Protein Sorting Signals; D011506:Proteins; D022821:RNA Splice Sites