Speckles in laser Doppler perfusion imaging.
We report on the quantitative influence of speckles in laser Doppler perfusion imaging. The influence of speckles on the signal amplitude and on the Doppler spectrum is demonstrated experimentally for particle suspensions with different scattering levels and various beam widths. It is shown that the type of tissue affects the instrumental response through the effect of lateral light diffusion on the number of speckles involved in the detection process. These effects are largest for narrow beams.
Biomedical Technology Institute, Biophysical Engineering Group, University of Twente, P.O. Box 217, NL-7500AE Enschede, The Netherlands. v.rajan@tnw.utwente.nl
V
V
Rajan
B
B
Varghese
T G
TG
van Leeuwen
W
W
Steenbergen
D000465:Algorithms; D000818:Animals; D001158:Arteries / Q000502:physiology*; D016477:Artifacts; D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008027:Light; D008955:Models, Cardiovascular; D012542:Scattering, Radiation