A new radical-based route to calothrixin B.
[structure: see text] A high-yielding totally regioselective intramolecular homolytic acylation of a quinoline ring constitutes the key step in a new synthesis of the pentacyclic indolo[3,2-j]phenanthridine alkaloid calothrixin B.
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona 08028, Spain.
M-Lluïsa
ML
Bennasar
Tomàs
T
Roca
Francesc
F
Ferrando
D000458:Cyanobacteria / Q000737:chemistry; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D026121:Indole Alkaloids; C418327:calothrixin B