Regulation of cell adhesion by protein-tyrosine phosphatases. I. Cell-matrix adhesion.
Protein-tyrosine phosphatases are key regulators of protein tyrosine phosphorylation. More than merely terminating the pathways initiated by protein-tyrosine kinases, phosphatases are active participants in many signaling pathways. Signals involving tyrosine phosphorylation are frequently generated in response to cell-matrix adhesion. In addition, high levels of protein tyrosine phosphorylation generally promote disassembly or turnover of adhesions. In this brief review, we will discuss the role of protein-tyrosine phosphatases in cell-matrix adhesions.
Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA. keith_burridge@med.unc.edu
Keith
K
Burridge
Sarita K
SK
Sastry
Jennifer L
JL
Sallee
D002448:Cell Adhesion / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D017027:Protein Tyrosine Phosphatases