Calcium phosphate cement in musculoskeletal tumor surgery.
OBJECTIVE
Calcium phosphate cement (CPC) is an injectable biocompatible bone substitute that has been used for various applications in orthopedic surgery. However, no extensive clinical studies of the use of CPC to fill bone cavities after curettage of musculoskeletal tumors have been reported. The present study reviewed the results for 56 musculoskeletal tumors treated by curettage and CPC implantation.


METHODS
Assessment was based on clinical examination and radiographic findings. Variables for clinical assessment included pain, limb function, and complications. Median follow-up was 18.5 months (range 6-47 months).


RESULTS
One patient experienced post-operative fractures. Three patients displayed local recurrence. One patient developed post-operative superficial wound infection, and two patients with large bony defect exhibited non-infectious serous discharge. No serious adverse effects such as deep venous thrombosis, pulmonary embolism were encountered. In all cases, CPC was radiographically well adapted to the surrounding host bone as of final follow-up.


CONCLUSIONS
CPC appears to offer a useful bone substitute for the treatment of musculoskeletal tumors. As the follow-up period for this study was short, further long-term follow-up studies are needed.
Department of Orthopaedic Surgery, Mie University School of Medicine, 2-174, Edobashi, Tsu-city, Mie, Japan. matsumin@clin.medic.mie-u.ac.jp
Akihiko
A
Matsumine
Katsuyuki
K
Kusuzaki
Takao
T
Matsubara
Atsushi
A
Okamura
Noritaka
N
Okuyama
Shinichi
S
Miyazaki
Ken
K
Shintani
Atsumasa
A
Uchida
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements; D001842:Bone and Bones / Q000601:surgery; D002130:Calcium Phosphates; D002648:Child; D002675:Child, Preschool; D003475:Curettage; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000601:surgery*; D009369:Neoplasms / Q000601:surgery*; D011183:Postoperative Complications; D019736:Prostheses and Implants
D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate