Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts.
Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor alpha (ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio=1.44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63).
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. shearman@mit.edu
Amanda M
AM
Shearman
Jackie A
JA
Cooper
Paul J
PJ
Kotwinski
George J
GJ
Miller
Steve E
SE
Humphries
Kristin G
KG
Ardlie
Barbara
B
Jordan
Kathryn
K
Irenze
Kathryn L
KL
Lunetta
Stephanie C E
SC
Schuit
André G
AG
Uitterlinden
Huibert A P
HA
Pols
Serkalem
S
Demissie
L Adrienne
LA
Cupples
Michael E
ME
Mendelsohn
Daniel
D
Levy
David E
DE
Housman
D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology* / Q000235:genetics; D016017:Odds Ratio; D012307:Risk Factors
D047628:Estrogen Receptor alpha