Is there a relationship between serum C-reactive protein level and dyslipidaemia in systemic lupus erythematosus?
OBJECTIVE
to look for the association between CRP and dyslipidaemia in SLE.


METHODS
seventy six patients fulfilled the American College of Rheumatology criteria for classification of Systemic Lupus Erythematosus (SLE) (revised in 1997) were enrolled in our study. Clinical and laboratory measures included complete history and physical examination, determination of serum CRP level by latex agglutination test and lipid profile. Statistical significance of association was analysed by X2 test. T-test were used to compare values of each lipid component between positive and negative CRP group. All analyses were performed using the SPSS 10.0 computer software.


RESULTS
the study was done in 76 (73 female and 3 male) SLE patients. Dyslipidaemia was found in 57 patients (75.0%). Hypercholesterolemia was found in 31 patients (40.8%), hypertriglyceridemia in 33 patients (43.4%), low HDL cholesterol in 19 patients (25%) and high LDL cholesterol in 28 patients (36.8%). Patients with positive CRP (66 patients) demonstrated dyslipidaemia in 49 patients (74.2%) and patients with negative CRP (10 patients) showed dyslipidaemia in 8 patients (80.0%)(P 1.0). There was no association between CRP and abnormal values of each lipid component (cholesterol, triglyceride, HDL and LDL cholesterol)(P value 0.30, 0.74, 0.43, 0.15 respectively). There was also no association between CRP and dyslipidaemia as a whole (P 1.00). The difference between serum level of each lipid component between positive and negative CRP group was also non significant (P value 0.68, 0.90, 0.96, 0.59 respectively).


CONCLUSIONS
there was no association between CRP and dyslipidaemia in SLE patients. In the development of dyslipidaemia in SLE, factors other than inflammation should be put into consideration.
Division of Rheumatology, Departement of Internal Medicine, Faculty of Medicine, University of Indonesia-dr.Cipto Mangunkusumo Hospital, Jakarta.
Zuljasri
Z
Albar
Linda K
LK
Wijaya
D002097:C-Reactive Protein / Q000032:analysis*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015897:Comorbidity; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007841:Latex Fixation Tests; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000453:epidemiology; D008297:Male; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein