[Myocardial infarction in a young female smoker taking oral contraception].
A 33 year old woman suffered a lateral myocardial infarction for the first time, and was treated by pre-hospital thrombolysis and secondary angioplasty on the diagonal artery. Fifteen days before the cardiac event she had undergone a left ovarian cyst excision and left salpingectomy for an ectopic pregnancy. She was a moderate smoker and had been taking a second-generation biphasic minidose oral contraceptive (ethinyl-estradiol 30-40mg and levonorgestrel 150-200 mg) for about ten years. Fifteen days before the myocardial infarction and due to the ectopic pregnancy she had changed to a combined monophasic minidose oral contraceptive pill containing ethinylestradiol (30 mg) and drospirenone (3 mg). The eventual outcome was favourable, with no complications. In this article we discuss the possible implications of the various factors (oral contraceptive, tobacco use, and surgical intervention) in this young woman with a myocardial infarction.
Service de pharmacologie clinique. Centre Midi-Pyrénées de pharmacovigilance, faculté de médecine, 37, allées Jules Guesde. 31073 Toulouse Cedex.
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C
Cabou
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Lacroix
J
J
Roncalli
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Elbaz
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Caillaux
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Damase-Michel
J M
JM
Fauvel
J L
JL
Montastruc
D000328:Adult; D000736:Androstenes / Q000008:administration & dosage / Q000009:adverse effects; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology* / Q000628:therapy; D011247:Pregnancy; D011271:Pregnancy, Ectopic; D012907:Smoking / Q000009:adverse effects*
D000736:Androstenes; D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol; C035144:drospirenone