Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: a three year prospective study.
OBJECTIVE
To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy.


METHODS
In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure.


RESULTS
A statistically significant reduction in mean arterial pressure was demonstrated (P < 0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P < 0.001). A critical decrease in oxygen saturation (< 90%) was documented in 27 patients (2.4%).


CONCLUSIONS
Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.
Gasparović
Stojanka
S
Department of Anesthesiology, Dubrava University Hospital, Zagreb, Croatia.
Rustemović
Nadan
N
Opacić
Milorad
M
Premuzić
Marina
M
Korusić
Andelko
A
Bozikov
Jadranka
J
Bates
Tamara
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D016292:Procedural Sedation; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies
D006993:Hypnotics and Sedatives; D010100:Oxygen; D015742:Propofol