The role of the supplementary motor area (SMA) in word production.
The supplementary motor area (SMA) is a key structure for behavioral planning and execution. Recent research on motor control conducted with monkeys and humans has put to light an anatomical and functional distinction between pre-SMA and SMA-proper. According to this view, the pre-SMA would be involved in higher level processes while the SMA-proper would be more closely tied to motor output. We extended this general framework to the verbal domain, in order to investigate the role of the SMA in speech production. We conducted two speech production experiments with fMRI where we manipulated parameters such as familiarity, complexity or constraints on word selection. The results reveal a parcellation of the SMA into three distinct regions, according to their involvement in different aspects of word production. More specifically, following a rostrocaudal gradient, we observed differential activations related to lexical selection, linear sequence encoding and control of motor output. A parallel organization was observed in the dorsolateral frontal cortex. By refining its anatomical and functional parcellation, these results clarify the roles of the SMA in speech production.
Alario
F-Xavier
FX
Laboratoire de Psychologie Cognitive, CNRS and Université de Provence, Marseille, France. alario@up.univ-mrs.fr
Chainay
Hanna
H
Lehericy
Stéphane
S
Cohen
Laurent
L
D000328:Adult; D001931:Brain Mapping; D002755:Choice Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011932:Reading; D013997:Time Factors; D014705:Verbal Behavior / Q000502:physiology*
D010100:Oxygen