Antiviral antibody responses: the two extremes of a wide spectrum.
Viruses elicit a diverse spectrum of antiviral antibody responses. In this review, we discuss two widely used experimental model systems for viral infections - non-cytopathic lymphocytic choriomeningitis virus (LCMV) and acutely cytopathic vesicular stomatitis virus (VSV) - to analyse two fundamentally different types of antiviral antibody response. The basic principles found in these model infections are discussed in the context of other viral infections, and with regard to protective neutralizing versus non-protective enzyme-linked immunosorbent assay (ELISA)-detected antibody responses. Issues of antibody specificity, affinity and avidity, maturation and escape are discussed in the context of co-evolution of the host and viruses.
Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland.
Lars
L
Hangartner
Rolf M
RM
Zinkernagel
Hans
H
Hengartner
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D017578:Immunoglobulin Class Switching; D009500:Neutralization Tests; D027041:Somatic Hypermutation, Immunoglobulin; D014777:Virus Diseases / Q000276:immunology
D000914:Antibodies, Viral