A cost utility analysis of the right method for screening hemoglobin E among Thai pregnant women.
BACKGROUND
Inherited hemoglobin disorders are an important problem in many developing countries including Thailand. Of the several inherited hemoglobin disorders, hemoglobin E (HbE) (beta 26, GAG-AAG, Glu-Lys) is the most common hemoglobinopathy in Thailand. Presently, screening to identify carriers of hemoglobin disorders among pregnant subjects is an interesting topic in antenatal care in Thailand. Of late, many trials have been conducted to identify the right screening methods for the detection of hemoglobin disorders among Thai pregnant women. The common screening methods include red blood cell (RBC) index determination, application of mathematical model and hemoglobin electrophoresis.


METHODS
Here, the author presents an evaluation of the cost utility of those tests in medical practice in Thailand. The cost/utility of hemoglobin electrophoresis is the highest followed by RBC index determination, application of mathematical model and DCIP test.


RESULTS
Here, it can be shown that the cost per accurate diagnosis for DCIP is the least expensive.


CONCLUSIONS
It is interesting to note that DCIP also posed high sensitivity in the screening for HbE disorder. Therefore, this test is the best method for screening the population, particularly pregnant women, to identify carriers of hemoglobin disorders. It should be recommended as part of antenatal care in Thailand as well as its neighbouring countries which have a similar high rate of HbE disorder.
Department of Laboratory Medicine, Chulalongkorn University, 10330, Bangkok, Thailand. wviroj@yahoo.com
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Wiwanitkit
D003362:Cost-Benefit Analysis; D004586:Electrophoresis; D004906:Erythrocyte Count; D005260:Female; D006446:Hemoglobin E / Q000032:analysis* / Q000191:economics; D006453:Hemoglobinopathies / Q000175:diagnosis* / Q000191:economics; D006801:Humans; D008403:Mass Screening / Q000191:economics* / Q000379:methods; D008433:Mathematics; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000191:economics; D011296:Prenatal Diagnosis / Q000191:economics* / Q000379:methods; D011808:Quinone Reductases; D012680:Sensitivity and Specificity; D013785:Thailand
D006446:Hemoglobin E; D009247:NADH, NADPH Oxidoreductases; D011808:Quinone Reductases; C033633:dichlorophenolindophenol reductase