Preliminary analysis of toxicity of benzoxazinones and their metabolites for folsomia Candida.
The overall objective of this study was to explore the toxicity of benzoxazinone allelochemicals and their metabolites to Folsomia candida (Collembola: Isotomidae) (Willem, 1902). Experimental tests showed transformation products to have more pronounced toxicity than parent compounds. The underlying relationship between the chemical structure and toxicity was then studied using three-dimensional QSAR approaches, and results highlighted the role of the steric contribution.
Lo Piparo
Elena
E
Istituto di Ricerche Farmacologiche "Mario Negri" Milano, Via Eritrea 62, 20157 Milano, Italy. lopiparo@marionegri.it
Smiesko
Martin
M
Mazzatorta
Paolo
P
Benfenati
Emilio
E
Idinger
Jacqueline
J
Blümel
Sylvia
S
D000818:Animals; D001181:Arthropods; D007306:Insecticides; D008958:Models, Molecular; D010078:Oxazines / Q000737:chemistry* / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship; D014908:Triticum / Q000737:chemistry
D007306:Insecticides; D010078:Oxazines