[The expression of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD].
OBJECTIVE
To investigate the expression of cyclooxygenase-2 in laryngeal squamous cell carcinoma and the correlation with tumor angiogenesis.


METHODS
The COX-2 and FVIII of 42 cases of laryngeal squamous cell carcinoma were detected by immunohistochemical SABC method,and the correlation between the expression rates, clinical significance and microvessel density(MVD) was analyzed.


RESULTS
The positive rate of COX-2 in laryngeal squamous cell carcinoma tissues and adjacent normal tissues were 71.43% and 19.05% respectively. The expression of COX-2 were not associated with age, sex, tumor site and T stage. The tumors of grade III approximately IV showed a higher COX-2 expression than tumors of grade I approximately II did and the expression of COX-2 in the cervical lymph node metastasis group was higher than that in the non-metastasis group. The expression of COX-2 was closely associated with microvessel density(MVD) of laryngeal squamous cell carcinoma.


CONCLUSIONS
The expression of COX-2 may play a crucial role in the carcinogenesis and development of laryngeal squamous cell carcinoma and cervical lymph node metastasis in patients with laryngeal squamous cell carcinoma. COX-2 may be a important factor in tumor angiogenesis.
Department of Otorhinoaryngology, Tongji Hospital of Tongji University, Shanghai, 200065, China.
Xicai
X
Sun
Rongming
R
Ge
Qinghan
Q
Dong
Chuanming
C
Zheng
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human