Antioxidants as novel agents for asthma.
Oxidative stress plays an important role in the pathogenesis of asthma. Recently several investigators have studied the effects of a variety of antioxidants on asthma. Antioxidants, including L-2-oxothiazolidine-4-carboxylic acid, reduce airway inflammation and hyper-responsiveness of asthma and may be novel therapeutic agents for asthma.
Park
Seoung Ju
SJ
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea.
Lee
Yong Chul
YC
D000111:Acetylcysteine / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D011761:Pyrrolidonecarboxylic Acid; D017382:Reactive Oxygen Species; D013844:Thiazoles / Q000627:therapeutic use; D053778:Thiazolidines
D018927:Anti-Asthmatic Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species; D013844:Thiazoles; D053778:Thiazolidines; D005978:Glutathione; D003545:Cysteine; D011761:Pyrrolidonecarboxylic Acid; D000111:Acetylcysteine; C029536:2-oxothiazolidine-4-carboxylic acid