Signaling protein complexes associated with neuronal ion channels.
The pore-forming subunits of many ion channels exist in the membrane as one component of a regulatory protein complex, which may also contain one or more signaling proteins that contribute to the modulation of channel properties. Here I review this field, with emphasis on several different kinds of neuronal potassium channels for which the evidence for ion channel signaling complexes is most compelling. A key challenge for the future is to determine the roles of such signaling protein complexes in neuronal physiology and behavior.
Levitan
Irwin B
IB
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. levitani@mail.med.upenn.edu
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D007473:Ion Channels; D046911:Macromolecular Substances; D008565:Membrane Proteins; D015221:Potassium Channels; D011494:Protein Kinases