Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities.
The needles of Taxus wallichiana gave a taxoid 1-hydroxy- 2-deacetoxy-5-decinnamoyl-taxinine j, whose structure has been established by spectroscopic data and confirmed by X-ray crystallography. The taxoid possesses significant cytotoxic and immunomodulatory activity.
Chattopadhyay
Sunil K
SK
Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 221005, India. chattsk@yahoo.com
Pal
Anirban
A
Maulik
Prakas R
PR
Kaur
Tanpreet
T
Garg
Ankur
A
Khanuja
Suman Preet S
SP
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D008958:Models, Molecular; D008968:Molecular Conformation; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020946:Taxus / Q000737:chemistry*; D014747:Vinblastine / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology
C511134:1-hydroxy- 2-deacetoxy-5-decinnamoyl-taxinine j; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D043823:Taxoids; D003208:Concanavalin A; D014750:Vincristine; D014747:Vinblastine