Tumours and tremors: how PTEN regulation underlies both.
Mutations of the tumour suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are seen in many human cancers. However, dysregulation of PTEN may be involved in other disease states such as Parkinson's disease. This minireview describes recent work examining PTEN regulation and its implications for the development of both cancer and neurodegenerative disease.
Campbell Family Institute for Breast Cancer Research, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada.
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D000818:Animals; D002471:Cell Transformation, Neoplastic; D004331:Drosophila melanogaster / Q000235:genetics; D005091:Exons; D005786:Gene Expression Regulation; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000502:physiology*; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology*; D015398:Signal Transduction
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human