Application of gold nanoparticles to microencapsulation of thioridazine.
Thioridazine-containing ethyl cellulose (EC) microcapsules were prepared in the presence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The gold nanoparticles have been verified as human safe and the nondestructive physisorption of thioridazine on gold nanoparticles was corroborated with the time-of-flight second ion mass spectrometry measurements. The morphology of the formed microcapsules (ETA, containing EC, Thioridazine and Au) changed substantially because of the presence of gold nanoparticles. In addition to a prolonged controlled release, these ETA microcapsules had an enhanced thioridazine encapsulation with an efficiency over one and half times that of the microcapsules (ET) containing no nanogold particles. While data of the release kinetics for ET microcapsules fitted the apparent first-order model, corresponding data for ETA microcapsules agreed better with the Higuchi model indicating a uniform distribution of thioridazine in the monolithic-type microcapsules.
Department of Chemical Engineering, National Chung Cheng University, Chiayi 621, Taiwan, ROC.
Mei-Kuan
MK
Lai
Ching-Yu
CY
Chang
Yi-Wen
YW
Lien
Raymond Chien-Chao
RC
Tsiang
D000818:Animals; D014150:Antipsychotic Agents / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D003692:Delayed-Action Preparations; D006046:Gold / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D011817:Rabbits; D051381:Rats; D012882:Skin Tests; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical; D013818:Thermogravimetry; D013881:Thioridazine / Q000737:chemistry* / Q000633:toxicity
D014150:Antipsychotic Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D006046:Gold; C013517:ethyl cellulose; D002482:Cellulose; D013881:Thioridazine