Power of breathing determined noninvasively with use of an artificial neural network in patients with respiratory failure.
OBJECTIVE
To determine work of breathing per minute or power of breathing noninvasively (POB(N)) by using an artificial neural network (ANN) without the need for an esophageal catheter in patients with respiratory failure.


METHODS
Prospective study comparing the relationship between POB(N) and invasively measured power of breathing (POB(I)).


METHODS
Intensive care unit of a university hospital.


METHODS
Forty-five intubated adults (age, 51 +/- 11 yrs; weight, 71 +/- 18 kg; 28 males and 17 females) receiving pressure support ventilation (PSV).


METHODS
Data from an esophageal catheter and airway pressure/flow sensor were used to measure POB(I). A pretrained ANN provided real time calculation of POB(N). POB(I) and POB(N) were measured at various levels of PSV, ranging from 5 to 25 cm H(2)O.


RESULTS
POB(N) was highly correlated with POB(I) (r = 0.91; p < .002), and because POB(N) explained or predicted 83% of the variance in POB(I), it was considered a very good predictor (r(2) = 0.83; p < .002). Bias was negligible (0.00) and precision was clinically acceptable (2.2 J/min).


CONCLUSIONS
POB can be calculated noninvasively with reasonable clinical accuracy for patients receiving ventilatory support by using an ANN. This method obviates the need for inserting an esophageal catheter and thus greatly simplifies measurement of POB. POB(N) may be a clinically useful tool for consideration when setting PSV to unload the respiratory muscles. Before considering its use in clinical practice, POB(N) would need to be incorporated within the context of load tolerance and shown to improve outcomes.
Banner
Michael J
MJ
Department of Anesthesiology, University of Florida College of Medicine, Gainesville, USA.
Euliano
Neil R
NR
Brennan
Vic
V
Peters
Carl
C
Layon
A Joseph
AJ
Gabrielli
Andrea
A
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D011446:Prospective Studies; D012119:Respiration; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000503:physiopathology* / Q000628:therapy*