HLA non-class II genes may confer type I diabetes susceptibility in a Mapuche (Amerindian) affected family.
A rare case of type I diabetes is studied in an Amerindian (Mapuche) family from Chile, analyzing glutamic acid decarboxylase, islet-cell autoantibodies and human leukocyte antigen (HLA) genes. The affected sib is the only one that has one specific HLA haplotype combination that differs from the other sibs only in the HLA class I genes. It is concluded that HLA diabetes susceptibility factors may be placed outside the class II region or even that susceptibility factors do not exist in the HLA region in this Amerindian family.
Genetic Epidemiology Laboratory, INTA-University of Chile, Santiago, Chile.
Francisco
F
Pérez-Bravo
Jorge
J
Martinez-Laso
Jose M
JM
Martin-Villa
Juan
J
Moscoso
Almudena
A
Moreno
Juan I
JI
Serrano-Vela
Jorge
J
Zamora
Silvia
S
Asenjo
Andrea
A
Gleisner
Antonio
A
Arnaiz-Villena
D000328:Adult; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D035781:Siblings
D005819:Genetic Markers; D006684:HLA-DR Antigens