Clinical-parasitological response and in-vitro sensitivity of Plasmodium vivax to chloroquine and quinine on the western border of Thailand.
This study was conducted during 2002-2004 at Mae Sot District, on the Thai-Myanmar border, an area of multidrug-resistant Plasmodium falciparum malaria. Sixty-two patients with P. vivax malaria were included in the study. All were randomized into two groups to receive a 3-day regimen of chloroquine or a 3-day regimen of quinine. Primaquine was given to patients in both groups for the elimination of hepatic stages. Results from the present study suggest that the standard regimen of chloroquine and a 3-day course of quinine at the dose regimens under investigation were very effective and well tolerated for the treatment of P. vivax malaria in this area. All patients responded well to both drug regimens; the cure rates with chloroquine or quinine, when given concurrently with the tissue schizontocidal drug primaquine, were virtually 100% within 28 days of follow-up. No significant correlations between parasite clearance time (PCT) or fever clearance time (FCT) and inhibitory concentration 50 (IC50) were found. Patients who had PCT < or = 24 h and those with PCT >24 h had comparable IC50 to chloroquine (alone and plus primaquine) and quinine, as well as similar concentrations of chloroquine/desethylchloroquine (in blood) or quinine (in plasma) at the investigated time points.
Pharmacology and Toxicology Unit, Faculty of Allied Health Sciences, Thammasat University (Rangsit Campus), Paholyothin Road, Pathumthani 12121, Thailand.
Oumaporn
O
Tasanor
Ronnatrai
R
Ruengweerayut
Jeerapat
J
Sirichaisinthop
Kanungnit
K
Congpuong
Walther H
WH
Wernsdorfer
Kesara
K
Na-Bangchang
D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000627:therapeutic use*; D002738:Chloroquine / Q000097:blood / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D002052:Myanmar; D021261:Parasitic Sensitivity Tests; D010966:Plasmodium vivax / Q000187:drug effects*; D011803:Quinine / Q000097:blood / Q000627:therapeutic use*; D013785:Thailand
D000962:Antimalarials; D002738:Chloroquine; D011803:Quinine