Unified method for Bayesian calculation of genetic risk.
Bayesian inference has been used for genetic risk calculation. In this traditional method, inheritance events are divided into a number of cases under the inheritance model, and some elements of the inheritance model are usually disregarded. We developed a genetic risk calculation program, GRISK, which contains an improved Bayesian risk calculation algorithm to express the outcome of inheritance events with inheritance vectors, a set of ordered genotypes of founders, and mutation vectors, which represent a new idea for description of mutations in a pedigree. GRISK can calculate genetic risk in a common format that allows users to execute the same operation in every case, whereas the traditional risk calculation method requires construction of a calculation table in which the inheritance events are variously divided in each respective case. In addition, GRISK does not disregard any possible events in inheritance. This program was developed as a Japanese macro for Excel to run on Windows.
Kuno
Shin-Ichi
SI
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan. omoikane@tri-kobe.org.|Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, 1-5-4 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan. omoikane@tri-kobe.org.|Clinical Genome Informatics Center, Kobe University Graduate School of Medicine, Kobe, Japan. omoikane@tri-kobe.org.
Furihata
Shiori
S
Japan Biological Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan.|Mitsubishi Research Institute, Tokyo, Japan.
Itou
Toshikazu
T
Mitsubishi Research Institute, Tokyo, Japan.
Saito
Kayoko
K
Institute of Medical Genetics, Tokyo Women's Medical University, Tokyo, Japan.
Kamatani
Naoyuki
N
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.|Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.
D000465:Algorithms; D000483:Alleles; D001499:Bayes Theorem; D041321:Chromosomes, Human, X; D005260:Female; D005817:Genetic Counseling; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D010375:Pedigree; D011247:Pregnancy; D011296:Prenatal Diagnosis; D040641:Quantitative Trait Loci; D012307:Risk Factors; D012984:Software
D005819:Genetic Markers