The influence of bio-behavioural factors on tumour biology: pathways and mechanisms.
Epidemiological studies indicate that stress, chronic depression and lack of social support might serve as risk factors for cancer development and progression. Recent cellular and molecular studies have identified biological processes that could potentially mediate such effects. This review integrates clinical, cellular and molecular studies to provide a mechanistic understanding of the interface between biological and behavioural influences in cancer, and identifies novel behavioural or pharmacological interventions that might help improve cancer outcomes.
Antoni
Michael H
MH
Department of Psychology, Sylvestor Cancer Center, University of Miami, P.O. Box 248185, Coral Gables, Florida 33124, USA.
Lutgendorf
Susan K
SK
Cole
Steven W
SW
Dhabhar
Firdaus S
FS
Sephton
Sandra E
SE
McDonald
Paige Green
PG
Stefanek
Michael
M
Sood
Anil K
AK
D000818:Animals; D003863:Depression / Q000150:complications; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control / Q000523:psychology; D012307:Risk Factors; D015398:Signal Transduction; D012944:Social Support; D012959:Socioeconomic Factors; D013315:Stress, Psychological / Q000150:complications