Interference with redox-active enzymes as a basis for the design of antimalarial drugs.
Antimalarial drugs are urgently and continuously required. Parasite enzymes involved in antioxidant defence represent interesting target molecules for rational drug development. Here we summarize the currently available data on structural, biochemical, and functional properties of these proteins in an attempt to evaluate and compare their potential as drug targets.
Rahlfs
S
S
Interdisciplinary Research Center, Heinrich-Buff-Ring 26-32, Justus-Liebig-University, D-35392 Giessen, Germany.
Becker
K
K
D000595:Amino Acid Sequence; D000962:Antimalarials / Q000737:chemistry; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction
D000962:Antimalarials; D004791:Enzyme Inhibitors; D004798:Enzymes