Regulation of Par6 by extracellular signals.
The critical regulator of polarity, Par6, is a key member of a multi-component polarity complex that controls a variety of cellular processes such as asymmetric cell division, establishment of epithelial apico-basal polarity, and polarized cell migration. Recently, we have come to understand how regulation of the Par6 interactome by extracellular cues such as integrin and transforming growth factor beta signalling regulates cell motility and tight junction dissolution. These studies have begun to elucidate how signalling to the polarity complex might regulate pathological processes such as tumour cell invasion and metastasis.
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada.
Rohit
R
Bose
Jeffrey L
JL
Wrana
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology
D011506:Proteins; D016212:Transforming Growth Factor beta