A new probe to monitor the effects of drugs on local field potentials.
We describe a new device with which microdialysis can be combined with bipolar local field potential (LFP) recordings. The device consists of a microdialysis probe with two ultra-thin electrical wires located within its tip. The device can be used to monitor LFPs with differential recording methods before, during, and after local application of drugs by reverse microdialysis, while concomitantly sampling biochemical constituents from the area of recording.
Darbin
Olivier
O
Department of Visual Sciences, Yerkes National Primate Center, Emory University, Neuroscience Building, Atlanta, GA 30322, USA. odarbin@emory.edu
Newton
Lauren
L
Wichmann
Thomas
T
D000818:Animals; D004569:Electroencephalography / Q000379:methods; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology*; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology; D008253:Macaca mulatta; D017551:Microdialysis; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods*; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology*; D011724:Pyridazines / Q000494:pharmacology
D018756:GABA Antagonists; D011724:Pyridazines; C049853:gabazine