Looking for the target cell of Kaposi's sarcoma-associated herpesvirus.
The level of Kaposi's sarcoma-associated herpesvirus (KSHV) cellular viremia in patients with Kaposi's sarcoma could be related to both the tumor burden and its progression. The origin of the spindle cell, the hallmark cell of Kaposi's sarcoma, is still debated. Two hypotheses may be formulated, favoring a lymphatic endothelial cell or an endothelial-cell precursor evolving into a lymphatic phenotype, both preferentially targeted by KSHV.
Service de Dermatologie, Hôpital Cochin, Laboratoire de Recherche en Dermatologie, Unité UPRES1833, Faculté de Médecine Paris V, Université René Descartes, Paris, France. nicolas.dupin@cch.ap-hop-paris.fr
Nicolas
N
Dupin
Philippe A
PA
Grange
D018450:Disease Progression; D042783:Endothelial Cells / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014766:Viremia / Q000150:complications*