Dendritic folate rosettes as ion channels in lipid bilayers.
The self-assembly of folate dendrimers into pi-stacked supramolecular rosettes is shown to produce ion channels in planar and spherical lipid bilayer membranes. The found ion channels are small, quite homogeneous, long-lived, ohmic, cation selective (Eisenman I), and blockable by the permeant cation.
Department of Organic Chemistry, University of Geneva, Geneva, Switzerland. naomi.sakai@chiorg.unige.ch
Naomi
N
Sakai
Yuko
Y
Kamikawa
Masayuki
M
Nishii
Toru
T
Matsuoka
Takashi
T
Kato
Stefan
S
Matile
D005492:Folic Acid / Q000737:chemistry*; D007476:Ionophores / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
D007476:Ionophores; D008051:Lipid Bilayers; D011108:Polymers; D005492:Folic Acid