A case of nodular scleroderma.
Nodular scleroderma is a rare complication of systemic sclerosis; the pathogenetic implications are still unknown, although many factors are supposed to play a role in lesion development. We report the case of a young woman suffering from systemic sclerosis, who developed nodular lesions during therapeutic management with D-penicillamine and plasmapheresis. In order to better understand the essence of this disease, we examined all the possible pathogenetic mechanisms that could be implicated in nodular lesion development.
Melani
Lucilla
L
Department of Dermatological Sciences, University of Florence, Italy.
Caproni
Marzia
M
Cardinali
Carla
C
Antiga
Emiliano
E
Bernacchi
Elisabetta
E
Schincaglia
Emiliano
E
Fabbri
Paolo
P
D000328:Adult; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D010396:Penicillamine / Q000627:therapeutic use; D010956:Plasmapheresis / Q000379:methods; D018570:Risk Assessment; D012594:Scleroderma, Localized / Q000473:pathology* / Q000628:therapy*; D012595:Scleroderma, Systemic / Q000188:drug therapy / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome
D010396:Penicillamine