HLA association is different in children and adults with severe acquired aplastic anemia.
BACKGROUND
Severe aplastic anemia (SAA) is defined as pancytopenia caused by bone marrow failure. The pathogenesis of SAA is thought to involve autoimmune processes. Increased susceptibility to autoimmunity has been shown to be associated with several different HLA alleles. In SAA, few large studies based on data mainly from adults describe a positive HLA correlation with HLA-DR2 (DRB1*15) and HLA-B14.


METHODS
This study explored the HLA constitution of 181 children with SAA who were enrolled in the prospective multi-center study SAA94 between January 1994 and January 2002. The control group consisted of 303 healthy individuals of comparable demographic background. Allelic frequencies between patients and controls are compared using Fisher's exact test.


RESULTS
In our pediatric cohort, we describe a positive association with HLA-B14 (P = 0.0039), but no association of HLA-DR2 with SAA.


CONCLUSIONS
HLA associations appear to be different in children and adults with SAA. This might point towards a difference in pathophysiology between at least part of the children and adults.
Führer
Monika
M
Department of Onkology and Hematology, Dr. v. Haunersche Kinderklinik of the Ludwig-Maximilians-University of Munich, Munich, Germany. monika.fuehrer@med.uni-muenchen.de
Durner
Jürgen
J
Brünnler
Günter
G
Götte
Heiko
H
Deppner
Cornelia
C
Bender-Götze
Christine
C
Albert
Ekkehard
E
D000293:Adolescent; D000483:Alleles; D000741:Anemia, Aplastic / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D059909:HLA-B14 Antigen; D015802:HLA-DR2 Antigen / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies
D006680:HLA Antigens; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D015802:HLA-DR2 Antigen