[Sequelae of organ transplantation].
Transplant medicine has significantly changed the prognosis of diseases leading to terminal organ failure. It has evolved from an experimental procedure to standard therapy for liver, kidney and cardio-vascular diseases. Transplant medicine combines operative organ replacement with the management of severely ill patients before transplantation, as well as life-long follow-up of organ graft recipients. Ten year survival rates of 65% to over 90% have led to a steady increase of transplanted patients seen by general medical care providers which represents a challenge for practicing internists. Apart from organ-specific conditions, infectious, immunosuppressant-associated and metabolic consequences determine long-term survival. These include virus reactivation, graft rejection, anastomotic problems but more importantly general mortality determining factors such as diabetes, renal insufficiency and hypertension, which are often a consequence of immunosuppressant administration. They directly impact long-term survival. The awareness and treatment of these secondary conditions of organ transplantation in routine medical practice contributes significantly to secure the long term success of transplant medicine.
Ciesek
S
S
Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover.
Manns
M
M
Strassburg
C
C
D000714:Anastomosis, Surgical; D006084:Graft Rejection / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016031:Liver Transplantation; D009369:Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D009894:Opportunistic Infections / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality; D012307:Risk Factors; D015996:Survival Rate; D017741:Survivors
D007166:Immunosuppressive Agents