[Functional food and bioavailability in the target organ skin].
Reactive free radicals can be produced in the skin by the action of environmental factors, such as sun radiation and toxins. These radicals can damage the DNA, proteins and lipids of the living cells. The consequences can be skin aging, immune suppression and even skin cancer. Humans have developed a protective mechanism against the action of free radicals in the form of antioxidant substances. Several of these antioxidants cannot be produced by humans and have to be acquired via food, such as carotenoids. Optical, non-invasive methods, like resonance Raman spectroscopy, allow a qualitative and quantitative online detection of the kinetics of antioxidants such as carotenoids in the skin. By employing this method it has been shown that the uptake of carotenoids in food can lead to an accumulation in the skin. On the other hand, stress, illness and UV-radiation can reduce the concentration of antioxidant substances in the skin. A high concentration of antioxidant substances is protective and associated with a reduction in skin wrinkling.
Center of Experimental and Applied Cutaneous Physiology (CCP), Klinik für Dermatologie, Venerologie und Allergologie, Charité, Universitätsmedizin Berlin.
M
M
Darwin
S
S
Schanzer
A
A
Teichmann
U
U
Blume-Peytavi
W
W
Sterry
J
J
Lademann
D000975:Antioxidants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001628:Beverages; D001682:Biological Availability; D002338:Carotenoids / Q000008:administration & dosage / Q000493:pharmacokinetics; D003877:Dermatitis, Contact / Q000503:physiopathology / Q000517:prevention & control; D005502:Food; D006801:Humans; D000077276:Lycopene; D009753:Nutritive Value; D012815:Signal Processing, Computer-Assisted; D015595:Skin Aging / Q000187:drug effects / Q000528:radiation effects; D012879:Skin Physiological Phenomena; D013059:Spectrum Analysis, Raman / Q000295:instrumentation; D013471:Sunburn / Q000503:physiopathology / Q000517:prevention & control; D014466:Ultraviolet Rays / Q000009:adverse effects; D014675:Vegetables; D019207:beta Carotene / Q000008:administration & dosage / Q000493:pharmacokinetics
D000975:Antioxidants; D019207:beta Carotene; D002338:Carotenoids; D000077276:Lycopene