Metformin-related vitamin B12 deficiency.
Metformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.
Liu
Kin Wah
KW
Medical and Geriatric Unit, Shatin Hospital, New Territories, Hong Kong, China. kwliuhk@yahoo.com
Dai
Lok Kwan
LK
Jean
Woo
W
D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000139:chemically induced*
D007004:Hypoglycemic Agents; D008687:Metformin