A case of angiolymphoid hyperplasia with eosinophilia (ALHE) of the upper lip.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare. We report a case and review the literature of ALHE cases involving the oral mucosa. A 40-year-old man presented with a painless, 20 x 20 mm, submucosal nodule on the upper lip. Histological examination of lip biopsy specimens revealed an increase in many small vessels. The vascular walls consisted of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.
Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
Hiromi
H
Suzuki
Atsushi
A
Hatamochi
Masaki
M
Horie
Toshihiro
T
Suzuki
Soji
S
Yamazaki
D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D001707:Biopsy, Needle; D004802:Eosinophilia / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008047:Lip Diseases / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome