LCCL proteins of apicomplexan parasites.
The LCCL module is a conserved, autonomous protein-folding domain that has recently been found in several extracellular proteins of apicomplexan parasites including Plasmodium, Toxoplasma, Cryptosporidium and Theileria, identifying a new protein family in the Apicomplexa. The expression and structure of these modular proteins has fostered speculation about the roles of these novel molecules in immune evasion. Here, the current data and literature on the members of this protein family are reviewed, with a discussion on their possible roles in host-parasite interaction.
Dessens
Johannes T
JT
Department of Biological Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, Imperial College Road, London, SW7 2AZ, UK.
Sinden
Robert E
RE
Claudianos
Charles
C
D000595:Amino Acid Sequence; D000818:Animals; D016782:Apicomplexa / Q000737:chemistry* / Q000276:immunology / Q000502:physiology; D006790:Host-Parasite Interactions; D006801:Humans; D008969:Molecular Sequence Data; D017510:Protein Folding; D017434:Protein Structure, Tertiary / Q000502:physiology; D015800:Protozoan Proteins / Q000737:chemistry / Q000502:physiology*
D015800:Protozoan Proteins