Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase.
The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 microM.
College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
Hyun Mi
HM
Oh
Byoung-Mog
BM
Kwon
Nam-In
NI
Baek
Sung-Hoon
SH
Kim
Jae Hyeok
JH
Lee
Jae Soon
JS
Eun
Jae Heon
JH
Yang
Dae Keun
DK
Kim
D019659:Asteraceae / Q000737:chemistry*; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007783:Lactones; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes; D012997:Solvents
C509025:6-O-angeloylprenolin; D004791:Enzyme Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D012997:Solvents; D051231:Farnesyltranstransferase; D000432:Methanol