CATERPILLERs, pyrin and hereditary immunological disorders.
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This family has gained rapid prominence because of its demonstrated and anticipated roles in immunity, cell death and growth, and diseases. CATERPILLER proteins are structurally similar to a subgroup of plant-disease-resistance (R) proteins and to the apoptotic protease activating factor 1 (APAF1). They provide positive and negative signals for the control of immune and inflammatory responses, and might represent intracellular sensors of pathogen products. Most importantly, they are genetically linked to several human immunological disorders.
Ting
Jenny P-Y
JP
Department of Microbiology-Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA. panyun@med.unc.edu
Kastner
Daniel L
DL
Hoffman
Hal M
HM
D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D010505:Familial Mediterranean Fever / Q000235:genetics; D005802:Genes, MHC Class II; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology / Q000235:genetics*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D009154:Mutation; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000502:physiology*; D053473:Nod2 Signaling Adaptor Protein; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*
D002352:Carrier Proteins; D007375:Interleukin-1; D047908:Intracellular Signaling Peptides and Proteins; C083728:MHC class II transactivator protein; C496800:NAIP protein, human; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; C429018:NOD2 protein, human; D051616:Neuronal Apoptosis-Inhibitory Protein; D053473:Nod2 Signaling Adaptor Protein; D009687:Nuclear Proteins; D015534:Trans-Activators