Cancer prevention trials and primary care physicians: factors associated with recommending trial enrollment.
BACKGROUND
To explore the willingness of primary care providers (PCPs) to encourage enrollment of patients into cancer prevention trials.


METHODS
A self-administered survey was mailed to a random sample of PCPs in three geographic regions. Physicians were asked questions about their knowledge and attitudes towards cancer prevention trials. We presented a clinical vignette of a woman at high risk for breast cancer and asked if they would encourage her enrollment into a breast cancer chemoprevention trial (yes/no). Each survey included one of 16 possible clinical vignettes where patient characteristics (age, race socioeconomic status, physical mobility and co-morbidity) varied dichotomously. Bivariate analyses and logistic models were used to examine the independent effects of patient and physician characteristics on physician decisions.


RESULTS
Two hundred and sixty-six surveys (50% response) were analyzed. The mean age of respondents was 48; 54% were White, 35% Asian and 5% Black. By design physicians were evenly distributed by gender, specialty and geographic location. Overall, 53% would encourage enrollment into a breast cancer chemoprevention trial. Significant predictors of a recommendation to enroll were: geographic location in California or Georgia, younger vignette patient and anticipating an increase in patient trust after recommending enrollment.


CONCLUSIONS
PCPs are less likely to encourage elderly patients to enroll into cancer chemoprevention trials. Decisions differ based on geographic location and perceived trust in the patient-provider relationship. To achieve successful enrollment, trial investigators must continue to educate PCPs and ensure a strong PCP-patient relationship is maintained.
Women's Health Unit, Section of General Internal Medicine, Evans Department of Medicine, Boston University School of Medicine, 720 Harrison Avenue, DOB Suite 1108, Boston, MA 02118-2334, USA. Tracy.Battaglia@bmc.org
Tracy A
TA
Battaglia
Arlene
A
Ash
Marianne N
MN
Prout
Karen M
KM
Freund
D000368:Aged; D001291:Attitude of Health Personnel; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D003376:Counseling / Q000706:statistics & numerical data*; D003657:Decision Making; D005194:Family Practice / Q000706:statistics & numerical data*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control*; D010342:Patient Acceptance of Health Care / Q000523:psychology; D018579:Patient Selection; D010821:Physicians, Family; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*