Regulatory T cells in transplantation.
Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.
Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK. herman.waldmann@path.ox.ac.uk
Herman
H
Waldmann
Tse-Ching
TC
Chen
Luis
L
Graca
Elizabeth
E
Adams
Stephen
S
Daley
Stephen
S
Cobbold
Paul J
PJ
Fairchild
D000818:Animals; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D023001:Transplantation Tolerance / Q000276:immunology*