The role of lipopolysaccharide-binding protein in modulating the innate immune response.
Lipopolysaccharide-binding protein (LBP) has a well-established role in Gram-negative infection. New data suggest a more expanded role for LBP as a general recognition molecule. Several bacterial surface components from Gram-positive pathogens are also recognized by this molecule. LBP may also serve as a clinical marker in severe infections and may carry therapeutic potential.
Zweigner
Janine
J
Institut für Mikrobiologie und Hygiene, Charité-Universitaetsmedizin Berlin, Schumannstrasse 21/22, D-10117 Berlin, Germany.
Schumann
Ralf R
RR
Weber
Joerg R
JR
D000209:Acute-Phase Proteins / Q000276:immunology / Q000378:metabolism*; D001424:Bacterial Infections / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000276:immunology / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism*; D009181:Mycoses / Q000276:immunology; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein