Short- and long-term immune responses of CD-1 outbred mice to the scrub typhus DNA vaccine candidate: p47Kp.
Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge.
Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA.
Guang
G
Xu
Suchismita
S
Chattopadhyay
Ju
J
Jiang
Teik-Chye
TC
Chan
Chien-Chung
CC
Chao
Wei-Mei
WM
Ching
Allen L
AL
Richards
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis; D051379:Mice; D012285:Orientia tsutsugamushi / Q000276:immunology*; D012290:Rickettsial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D012612:Scrub Typhus / Q000276:immunology* / Q000517:prevention & control; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D013997:Time Factors; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
D000907:Antibodies, Bacterial; D012290:Rickettsial Vaccines; D019444:Vaccines, DNA; D007371:Interferon-gamma