Primary anetoderma and HIV infection: a case report.
Anetoderma is characterized by circumscribed areas of flaccid skin caused by the loss of elastic tissue in the dermis. It may be primary or secondary to various dermatoses. The primary form has been reported in patients with autoimmune diseases, increased levels of antiphospholipid antibodies, prothrombotic abnormalities, and recently, HIV-1 disease. The origin of anetoderma remains unknown. A case of primary anetoderma is reported in a 45-year-old man with asymptomatic HIV-1 infection who was receiving antiretroviral therapy. Laboratory research included the classic immunologic investigations and screening for prothrombotic abnormalities. Possible pathogenic mechanisms of anetoderma, especially with respect to HIV-1 infection and antiretroviral therapy, are discussed.
Mastrolorenzo
Antonio
A
Center for STD & AIDS, Department of Dermatological Sciences, University of Florence, Italy.
Tiradritti
Luana
L
Vichi
Francesca
F
Ketabchi
Sheyda
S
Supuran
Claudiu T
CT
Zuccati
Giuliano
G
D004547:Elastic Tissue / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000209:etiology / Q000276:immunology* / Q000473:pathology*