[Safety of intra-arterial autologous bone marrow mononuclear cell transplantation for acute ischemic stroke].
Stroke is the third cause of death and the leading cause of disability in adult subjects. Although stroke mortality has been declining in some countries, stroke morbidity has been increasing due to the aging of population and patients improved survival. Treatment with recombinant tissue plasminogen activator (rtPA) is successful provided it is administered within 3 hours of symptoms onset, but its use is limited to about 5% of the patients with acute ischemic stroke. Furthermore, no neuroprotective agent has yet been proven effective in human clinical trials. The development of other therapeutic strategies is, therefore, warranted. The use of stem cells in animal models has led to functional improvement following stroke. Recent publications have shown that bone marrow mononuclear cells (BM-MNC) therapy through intracoronary injection is a safe procedure in patients with acute or chronic ischemic heart disease. Based on these preliminary data, there has been growing interest in the study of BM-MNC transplantation for acute ischemic stroke. We report the first case of intra-arterial autologous BM-MNC transplantation for acute ischemic stroke.
Hospital Pró-Cardíaco, Universidade Federal do Rio de Janeiro, Instituto do Milênio de Bioengenharia Tecidual, Rio de Janeiro, RJ.
Maria Lúcia Furtado de
ML
Mendonça
Gabriel R de
GR
Freitas
Suzana Alves da
SA
Silva
Aquiles
A
Manfrim
Carlos Henrique Eiras
CH
Falcão
Constantino
C
Gonzáles
Charles
C
André
Hans Fernando Rocha
HF
Dohmann
Radovan
R
Borojevic
Rosália Mendez
RM
Otero
D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005434:Flow Cytometry; D006801:Humans; D007269:Injections, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy / Q000601:surgery*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator