[Expression of CD25+ lymphocytes in nasopharyngeal carcinoma and its association with EBV infection].
OBJECTIVE
To investigate the expression of CD25(+) lymphocytes in nasopharyngeal carcinoma (NPC) tissue and the influence of Epstein-Barr virus (EBV) infection on CD25 expression.


METHODS
Immunohistochemistry was used to detect CD25 expression in the NPC tissues and in situ hybridization employed to detect EBV infection with chronic nasopharyngitis tissue as the control sample.


RESULTS
Significant difference was noted in the expression of CD25(+) lymphocytes between NPC and chronic inflammatory tissues. The expression was higher in undifferentiated NPC than in keratinizing squamous cell carcinoma and non-keratinizing carcinomas. The NPC tissue was all EBV-positive except for one sample, which was identified as keratinizing carcinoma, but the control samples were all negative for EBV infection, which was correlated with CD25 expression.


CONCLUSIONS
The expression of CD25(+) lymphocytes is higher in NPC tissues and correlated to EBV infection.
Department of Pathology, Southern Medical University, Guangzhou 510515, China. lwei209@126.com
Wei
W
Liu
Hui-xia
HX
Han
D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D053645:Interleukin-2 Receptor alpha Subunit / Q000096:biosynthesis*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000821:virology*
D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit