[Effect of gufuhuo decoction on local apoptosis of steroid-induced necrosis of femoral head].
OBJECTIVE
To observe the bone specimen of SANFH (steroid-induced avascular necrosis of femoral head) and the effect of Gufuhuo decoction on local apoptosis of SANFH.


METHODS
Model rabbits of necrosis of femoral head, made by intragluteal injection with prednisone acetate, were killed after 6 weeks to study the apoptosis by means of TUNEL.


RESULTS
A great number of faded osteocytes and osteoblasts existed in specimen of SANFH. There was significant difference in apoptosis indexes between model and control group, Gufuhuo decoction and Xianlinggubao group (P < 0.05).


CONCLUSIONS
In the course of SANFH, the necrosis results from the interaction of apoptosis and necrosis of steroid-induced osteocytes and osteoblasts. Gufuhuo decoction has some effects on improving apoptosis and necrosis of SANFH.
Tian
Wei-ming
WM
Traditional Chinese Medicine Hospital, Hebei Medical University, Shijiazhuang, China.
Wang
Wen-zhi
WZ
Wang
Xin-guo
XG
Xu
Guo-hua
GH
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000473:pathology*; D020287:In Situ Nick-End Labeling; D007865:Leeches / Q000737:chemistry; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology; D010006:Osteoblasts / Q000473:pathology*; D010011:Osteocytes / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry; D011241:Prednisone; D011817:Rabbits; D011897:Random Allocation
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D011241:Prednisone