A case of pheniramine dependence.
Abuse and addiction of histaminergic agonists and antagonists were investigated. The withdrawal signs may become after using drugs such as L-histidine, histamine-N-methyl, promethazine, pheniramine, astemizole, etc. Some medicines which include these active metabolites could lead to dependence cause different side effects. This case suggests that pheniramine abuse also could to dependence. We should pay attention to trend of pheniramine and other histaminergic drugs dependence and need to regulate the market by law more severely.
Bakirkoy Research Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey. osaatcioglu@superonline.com
Omer
O
Saatcioglu
Cuneyt
C
Evren
D000328:Adult; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D010632:Pheniramine / Q000008:administration & dosage / Q000009:adverse effects; D012651:Self Medication; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000523:psychology; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000523:psychology; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology
D018926:Anti-Allergic Agents; D006634:Histamine H1 Antagonists; D010632:Pheniramine