[Relationship between insulin like hormone 3 and testicular descent and development].
Testicular descent is an essential step in the course of reproductive system development. The mechanisms involved in the regulation of testis descent is not distinct. Gubernaculum has a very close relationship with testis descent. Maldescent of testis can cause abnormalities of genital system such as testicular underwent (cryptorchidism), dysplasia, tumor, infertility and low sexuality. Recently insulin like hormone 3 is a hotspot of concerning affecting gubernacular development and testicular descent. This article briefly reviews the advances in these aspects.
Xie
Xiao-jun
XJ
Department of Pediatric Surgery, the Second Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China. xiexiaojun11908@tom.com
Jiang
Xue-Wu
XW
D000818:Animals; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011506:Proteins / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D013737:Testis / Q000254:growth & development*
D007328:Insulin; C084797:Leydig insulin-like protein; D011506:Proteins; D043562:Receptors, G-Protein-Coupled