Mechanisms of action of new treatment modalities for actinic keratosis.
Actinic keratosis (AK) constitutes the initial lesion in a disease continuum that can progress to invasive squamous cell carcinoma (SCC). In this article, we describe the mechanisms of action, tolerability, and efficacy of the most frequently used chemopreventative, chemotherapeutic, destructive, and novel immunologic methods for the control and treatment of actinic keratoses.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Brian
B
Berman
Adariana M
AM
Villa
Claudia C
CC
Ramirez
D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D000963:Antimetabolites / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004008:Diclofenac / Q000009:adverse effects / Q000627:therapeutic use*; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D000077271:Imiquimod; D007642:Keratosis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D010778:Photochemotherapy / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D013723:Teratogens / Q000145:classification
D000634:Aminoquinolines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000963:Antimetabolites; D000970:Antineoplastic Agents; D013723:Teratogens; D004008:Diclofenac; D000077271:Imiquimod; D005472:Fluorouracil