PET modulated fluorescent sensing from the BF2 chelated azadipyrromethene platform.
A convergent building block synthesis has been applied to new off/on photoinduced electron transfer (PET) modulated fluorescent sensors which are based on a BF(2) chelated tetraarylazadipyrromethene platform and operate in the biomedically important red region of the visible spectrum. Incorporation of diethylamine and morpholine receptors facilitates off/on microenvironment polarity and pH sensing. Aqueous formulation and in vitro cellular imaging demonstrates their potential for intracellular sensing.
Centre for Synthesis and Chemical Biology, Conway Institute, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Michael J
MJ
Hall
Lorcan T
LT
Allen
Donal F
DF
O'Shea
D000475:Alkenes / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D001671:Biochemistry / Q000379:methods; D001896:Boron Compounds / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D003593:Cytoplasm / Q000378:metabolism; D004048:Diethylamines / Q000737:chemistry; D004579:Electron Transport; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009025:Morpholines / Q000737:chemistry; D010777:Photochemistry / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014269:Trifluoroacetic Acid / Q000737:chemistry
D000475:Alkenes; D001372:Aza Compounds; D001896:Boron Compounds; D002614:Chelating Agents; D004048:Diethylamines; D009025:Morpholines; C037574:morpholine; C034281:diethylamine; D014269:Trifluoroacetic Acid