Rhodium/phosphoramidite-catalyzed asymmetric arylation of aldehydes with arylboronic acids.
Phosphoramidites are effective chiral ligands in the rhodium catalyzed addition of arylboronic acids to aldehydes providing up to 75% enantioselectivity and up to 96% isolated yield.
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Richard B C
RB
Jagt
Patrick Y
PY
Toullec
Johannes G
JG
de Vries
Ben L
BL
Feringa
Adriaan J
AJ
Minnaard
D000447:Aldehydes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D001897:Boronic Acids; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D012238:Rhodium