Serotonin turnover in discrete regions of young rat brain after 24 h REM sleep deprivation.
The present study has attempted to elucidate the alteration of serotonin turnover after 24 h REM sleep deprivation in different regions in brain of young rat. Sleep deprivation was induced by the inverted flower pot technique. Results of this study show increased serotonin turnover after 24 h REM sleep deprivation in all the brain regions except in the hypothalamus. The decreased 5-HT ratio shows increased serotonin in the hypothalamus after 24 h sleep deprivation. This study indicates increased activity of serotonergic neurons in the hypothalamus after 24 h sleep deprivation. This also indicates that the hypothalamus plays a role in the immediate compensatory mechanism during 24 h REM sleep deprivation in young rats.
Department of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India. senthilvelan_77@yahoo.com
M
M
Senthilvelan
R
R
Ravindran
J
J
Samson
R Shella
RS
Devi
D000818:Animals; D001921:Brain / Q000378:metabolism*; D007031:Hypothalamus / Q000737:chemistry / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D012892:Sleep Deprivation; D012895:Sleep, REM / Q000502:physiology*
D012701:Serotonin