Syringoma-like eccrine sweat duct proliferation induced by radiation.
We report a 45-year-old woman with breast cancer who had undergone surgery and radiation and anti-estrogen therapy and presented with many reddish papules in the irradiated breast area. Skin biopsy of the affected area disclosed proliferation of eccrine sweat ducts and cystic structures; the clinical and histopathological features were consistent with syringoma-like eccrine sweat duct proliferation. The lesions spread rapidly on her chest during radiation therapy and regressed spontaneously 3 weeks after its completion. We postulate that the lesions were induced by radiation, and promoted by anti-estrogen therapy.
Yoshii
Noriko
N
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. yoshii@kagoderma.com
Kanekura
Takuro
T
Churei
Hisahiko
H
Kanzaki
Tamotsu
T
D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects; D013544:Sweat Gland Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D018252:Syringoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology