Adoptive transfer of myelin basic protein-induced experimental autoimmune encephalomyelitis between SJL and B10.S mice: correlation of priming milieus with susceptibility and resistance phenotypes.
To study the mechanisms of EAE resistance, we directly transfer MBP-primed EAE-susceptible SJL lymph node cells into EAE-resistant B10.S recipients and vice versa. These transfers were unsuccessful because of strong alloreactivity between the two strains. Neonatal tolerance to SJL antigens was induced in B10.S mice and in these hosts MBP-primed SJL lymph node cells readily induce development of adoptive EAE. Conversely, transfer of MBP-primed B10.S lymph node cells into EAE-susceptible (SJL x B10.S)F1 recipients failed to induce EAE. These results are consistent with the notion that the priming milieus in the donor mice affect the expression of susceptible and resistant phenotypes.
Chen
Fei
F
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Shaw
Michael K
MK
Li
Jinzhu
J
Lisak
Robert P
RP
Tse
Harley Y
HY
D019264:Adoptive Transfer; D000818:Animals; D000831:Animals, Newborn; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D007108:Immune Tolerance; D051379:Mice; D004676:Myelin Basic Protein / Q000276:immunology*
D004676:Myelin Basic Protein