Neuroproteomics in neurotrauma.
Neurotrauma in the form of traumatic brain injury (TBI) afflicts more Americans annually than Alzheimer's and Parkinson's disease combined, yet few researchers have used neuroproteomics to investigate the underlying complex molecular events that exacerbate TBI. Discussed in this review is the methodology needed to explore the neurotrauma proteome-from the types of samples used to the mass spectrometry identification and quantification techniques available. This neuroproteomics survey presents a framework for large-scale protein research in neurotrauma, as applied for immediate TBI biomarker discovery and the far-reaching systems biology understanding of how the brain responds to trauma. Ultimately, knowledge attained through neuroproteomics could lead to clinical diagnostics and therapeutics to lessen the burden of neurotrauma on society.
Center of Neuroproteomics and Biomarkers Research, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. aottens@mbi.ufl.edu
Andrew K
AK
Ottens
Firas H
FH
Kobeissy
Erin C
EC
Golden
Zhiqun
Z
Zhang
William E
WE
Haskins
Su-Shing
SS
Chen
Ronald L
RL
Hayes
Kevin K W
KK
Wang
Nancy D
ND
Denslow
D000818:Animals; D015415:Biomarkers; D001930:Brain Injuries / Q000134:cerebrospinal fluid / Q000235:genetics / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D005786:Gene Expression Regulation; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000134:cerebrospinal fluid / Q000235:genetics; D009483:Neuropsychological Tests; D009488:Neurosciences; D020543:Proteome; D040901:Proteomics
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D020543:Proteome