Chemoenzymatic syntheses of iGb3 and Gb3.
Efficient chemoenzymatic syntheses of iGb3 and Gb3 have been developed. Isoglobotrihexose and globotrihexose were enzymatically synthesized by a three-enzyme system in both solid and solution phases. Then iGb3 and Gb3 were chemically synthesized by coupling of the corresponding trisaccharides with lipid.
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Qingjia
Q
Yao
Jing
J
Song
Chengfeng
C
Xia
Wenpeng
W
Zhang
Peng George
PG
Wang
D000818:Animals; D002240:Carbohydrate Sequence; D005699:Galactosylceramides / Q000737:chemistry / Q000494:pharmacology; D005915:Globosides / Q000138:chemical synthesis* / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D014281:Trihexosylceramides / Q000138:chemical synthesis* / Q000378:metabolism; D014312:Trisaccharides
D005699:Galactosylceramides; D005915:Globosides; D014281:Trihexosylceramides; D014312:Trisaccharides; C514780:globotrihexosylceramide; C514781:isoglobotrihexosylceramide; C018549:globotriaosylceramide; D010727:Phosphoric Diester Hydrolases; C060071:UDP-galactose hydrolase; C103873:KRN 7000