High-density lipoprotein cholesterol-raising strategies.
There is a distinct inverse relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease risk. HDL-C mediates cholesterol efflux from the vasculature and promotes anti-oxidant, anti-inflammatory, and anti-thrombotic effects. There are multiple lifestyle and therapeutic interventions that raise HDL-C, and there is increasing evidence that these interventions improve cardiovascular outcomes. Recent findings regarding the role of HDL-C in cholesterol metabolism offer new strategies designed to target atherosclerosis. This review highlights the utility of existing HDL-C-raising strategies and examines new potential therapies.
Division of Cardiology, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine Boston, Massachusettes 0211, USA. jkuvin@tufts-nemc.org
Jeffrey T
JT
Kuvin
Alawi A
AA
Alsheikh-Ali
Richard H
RH
Karas
D016632:Apolipoprotein A-I / Q000097:blood; D001161:Arteriosclerosis / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000517:prevention & control*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008019:Life Style; D008297:Male; D008954:Models, Biological; D012307:Risk Factors
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D002784:Cholesterol