Brain natriuretic peptide plasma level is a reliable indicator of advanced diastolic dysfunction in patients with chronic heart failure.
The aim of the study was to determine the value of brain natriuretic peptide for the identification of diastolic dysfunction status in congestive heart failure. We studied 204 patients with stable heart failure. Brain natriuretic peptide plasma levels were correlated with echocardiographic parameters of diastolic dysfunction. Diastolic dysfunction was classified as mild (abnormal echocardiographic relaxation pattern) and severe (pseudo-normal or restrictive pattern). A significant correlation between brain natriuretic peptide levels and the other parameters was detected. Brain natriuretic peptide dosage, then, seems to be a reliable tool for the assessment of diastolic dysfunction status in patients with congestive heart failure.
Cardiology Department, S. Spirito Hospital, Lungotevere in Sassia 1, 00196 Rome, Italy. ab.scardovi@libero.it
Angela Beatrice
AB
Scardovi
Claudio
C
Coletta
Nadia
N
Aspromonte
Silvia
S
Perna
Manuela
M
Greggi
Paola
P
D'Errigo
Augusto
A
Sestili
Vincenzo
V
Ceci
D000368:Aged; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005240:Feasibility Studies; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D012720:Severity of Illness Index; D013223:Statistics as Topic
D020097:Natriuretic Peptide, Brain