A comparison of the electron ionization and electrospray behaviour of some N,N'-disubstituted hexahydropyrimidines.
The behaviour of some N,N'-disubstituted hexahydropyrimidines, a class of naturally occurring compounds of biological and biomedical interest, has been studied in both electron ionization (EI) and electrospray ionization (ESI) modes coupled with collisional experiments (ESI-MSn). In both techniques, the [M-H]+ ions are highly abundant, even if their formation is generated by two different mechanisms, i.e. H. loss from the M+. species in the case of EI and hydride (H-) abstraction from the molecules in the case of ESI. Furthermore, due to the low, step-by-step internal energy deposition typical of collisional experiments performed in an ion trap mass spectrometer, different fragment ions were observed in EI and ESI-MSn collisions. In both cases, the ions can be related to the original structure and allow us to identify the positions in which the different substituents are present.
Orelli
Liliana R
LR
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires. Junin 956, (1113) Buenos Aires, Argentina. lorelli@ffyb.uba.ar
García
María B
MB
Perillo
Isabel A
IA
Tonidandel
Loris
L
Traldi
Pietro
P
D001688:Biological Products / Q000737:chemistry; D004583:Electrons; D007477:Ions / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D001688:Biological Products; D007477:Ions; D011355:Prodrugs; D011743:Pyrimidines