Antiplasmodial flavonoids from Erythrina sacleuxii.
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4'-methoxy-3'-prenylisoflavone (trivial name 5-deoxy-3'-prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sacleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence.
Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Andrew W
AW
Andayi
Abiy
A
Yenesew
Solomon
S
Derese
Jacob O
JO
Midiwo
Peter M
PM
Gitu
Ogoche J
OJ
Jondiko
Hosea
H
Akala
Pamela
P
Liyala
Julia
J
Wangui
Norman C
NC
Waters
Matthias
M
Heydenreich
Martin G
MG
Peter
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D004895:Erythrina / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*
C509546:7-hydroxy-4'-methoxy-3'-prenylisoflavone; D000962:Antimalarials; D005419:Flavonoids; D007529:Isoflavones; D010936:Plant Extracts; D002738:Chloroquine