Mechanisms and strategies to overcome multiple drug resistance in cancer.
One of the major problems in chemotherapy is multidrug resistance (MDR) against anticancer drugs. ATP-binding cassette (ABC) transporters are a family of proteins that mediate MDR via ATP-dependent drug efflux pumps. Many MDR inhibitors have been identified, but none of them have been proven clinically useful without side effects. Efforts continue to discover not toxic MDR inhibitors which lack pharmacokinetic interactions with anticancer drugs. Novel approaches have also been designed to inhibit or circumvent MDR. In this review, the structure and function of ABC transporters and development of MDR inhibitors are described briefly including various approaches to suppress MDR mechanisms.
Ozben
Tomris
T
Akdeniz University, Faculty of Medicine, Department of Biochemistry, 07070 Antalya, Turkey. ozben@akdeniz.edu.tr
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000502:physiology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship
D018528:ATP-Binding Cassette Transporters