Mandible analysis in sex steroid-deficient rats.
The aim of this study was to evaluate, by morphologic techniques, the effects of sex steroid deficiency on mandible bone remodeling of female rats, in groups of different experimental periods and to compare the results with 90-day orquiectomized males. Female and male Wistar rats, 3 months old, were divided into experimental groups and at the end of each experimental period were killed, and mandibles were extracted. The left mandibles were prepared with rote technique bone and examined by a light microscope. Morphological analyses of the mandibles demonstrated resorption signals in the alveolar bone, after 30 days in ovariectomized females, but it was more intense 90 days after castration. The orquiectomized group exhibited some signals of resorption similar to the ovariectomized group of 60 days. Morphometric analysis of alveolar bone thickness in females after 60 days was in agreement with morphological results. However, the analysis of periodontal ligament thickness did not show any significant difference. There were variations in sexual hormone deficiency in the mandibles of males and females and they seemed to be more precocious in ovariectomized than in orquiectomized rats. It is important for a health professional to have knowledge about bone metabolism to improve the quality of life of postmenopaused and old people.
Department of Physiological Sciences, IBRAG, University of Rio de Janeiro State, RJ, Brazil. luadias@superig.com.br
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Armada
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Nogueira
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dos Santos Souza
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Armada-Dias
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Moreira
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Nascimento-Saba
D016301:Alveolar Bone Loss / Q000473:pathology / Q000503:physiopathology; D000539:Alveolar Process / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001835:Body Weight; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000473:pathology / Q000503:physiopathology; D002508:Cephalometry; D003094:Collagen; D003739:Dental Cementum / Q000473:pathology; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D007091:Image Processing, Computer-Assisted; D008297:Male; D008334:Mandible / Q000473:pathology / Q000503:physiopathology*; D009919:Orchiectomy; D010052:Ovariectomy; D010513:Periodontal Ligament / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000172:deficiency*; D013997:Time Factors
D004967:Estrogens; C074283:estradiol 3-benzoate; D013739:Testosterone; D004958:Estradiol; D003094:Collagen