Blistering mucocutaneous diseases of the oral mucosa--a review: part 2. Pemphigus vulgaris.
Oral mucous membranes may be affected by a variety of blistering mucocutaneous diseases. In this paper, we review the clinical manifestations, typical microscopic and immunofluorescence features, pathogenesis, biological behaviour and treatment of pemphigus vulgaris. Although pemphigus vulgaris is not a common disease of the oral cavity, its potential to cause severe or life-threatening disease is such that the general dentist must have an understanding of its pathophysiology, clinical presentation and management.
Department of Pathology, University of Western Ontario, London, Ontario. mark.darling@schulich.uwo.ca
Mark R
MR
Darling
Tom
T
Daley
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001323:Autoantibodies; D051184:Desmoglein 3 / Q000276:immunology; D003896:Desmosomes / Q000473:pathology; D005891:Gingivitis / Q000150:complications; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D009059:Mouth Diseases / Q000473:pathology* / Q000628:therapy; D009061:Mouth Mucosa / Q000276:immunology / Q000473:pathology; D010392:Pemphigus / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D051184:Desmoglein 3; D011239:Prednisolone