Transfusion-related cytomegalovirus infection among very low birth weight infants in an endemic area.
This study investigated the incidence of acquired cytomegalovirus (CMV) infection in very low birth weight infants (VLBWI) given CMV seropositive blood, and sought to determine whether filtering and irradiation of blood products could help prevent CMV infection and the time required to clear passively-derived anti-CMV IgG among 80 VLBWI transfused with filtered-irradiated blood, 20 VLBWI transfused with nonfiltered- nonirradiated blood and 26 nontransfused VLBWI. CMV IgG and IgM values were obtained from all blood products prior to transfusions, and from VLBWI at birth until the infants became seronegative. Urine was obtained for CMV culture at birth and every 3-4 weeks until 12 weeks after the final transfusion. The incidence of CMV IgG seropositivity among the 126 infants at birth and the blood products given were 96% and 95%, respectively. The incidence of acquired CMV infection was 4/100 (4%) in the transfused group: 2/80 (2.5%) and 2/20 (10%) in the filtered-irradiated and nonfiltered-nonirradiated transfusion groups, respectively. Approximately 9-10 months elapsed to clear passively acquired CMV IgG. The irradiation and filtering of the blood products did not seem to decrease the transfusion-related CMV infection rate in Korea among VLBWI, however, further validation is recommended in a larger cohort of infants.
Division of Neonatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. arkim@amc.seoul.kr
Ai-Rhan Ellen
AR
Kim
Yeon Kyung
YK
Lee
Kyung Ah
KA
Kim
Young Kyu
YK
Chu
Byung Yoon
BY
Baik
Eun Soon
ES
Kim
Sung Cheol
SC
Yun
Ki Soo
KS
Kim
Soo Young
SY
Pi
D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D001803:Blood Transfusion / Q000379:methods; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification / Q000528:radiation effects; D003586:Cytomegalovirus Infections / Q000097:blood / Q000517:prevention & control / Q000635:transmission*; D005260:Female; D005374:Filtration / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D007363:Intensive Care Units, Neonatal; D016014:Linear Models; D008297:Male; D013997:Time Factors; D065227:Transfusion Reaction
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M