Cancer-associated thrombosis.
Thrombosis is one of the major complications of malignant disease, but the underlying molecular and cellular basis remains elusive. A number of hypotheses have been put forth, including the expression of tissue factor by tumor cells, release of tissue factor during cell death following chemotherapy, intrinsic unique tumor procoagulants and microparticles. Exploration of a potential role of microparticles in cancer-associated thrombosis indicates that tissue factor microparticles are present in a spectrum of cancer patients known to have a high incidence of thromboembolic complications.
Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. bfurie@bidmc.harvard.edu
Bruce
B
Furie
Barbara C
BC
Furie
D002462:Cell Membrane / Q000648:ultrastructure; D006801:Humans; D046911:Macromolecular Substances; D009369:Neoplasms / Q000150:complications* / Q000473:pathology; D010316:Particle Size; D013925:Thromboplastin / Q000378:metabolism / Q000502:physiology*; D013927:Thrombosis / Q000209:etiology*
D046911:Macromolecular Substances; D013925:Thromboplastin