A second leiomyosarcoma in the urinary bladder of a child with a history of retinoblastoma 12 years following partial cystectomy.
This case describes a twin with bilateral retinoblastoma who developed leiomyosarcoma of the bladder at age 17 and again at 39. At 17-years of age she was diagnosed with a leiomyosarcoma of the bladder after presenting with recurrent urinary tract infections, hematuria, and dysuria. She was treated with partial cystectomy. After a 12-year disease-free interval, she was diagnosed with a second leiomyosarcoma of the bladder. This case supports the relationship between the genetic form of retinoblastoma and leiomyosarcoma and illustrates the necessity for extensive follow-up and well-defined treatment of secondary neoplasms.
Brucker
Benjamin
B
Department of Urology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. benjamin.brucker@uphs.upenn.edu
Ernst
Linda
L
Meadows
Anna
A
Zderic
Stephen
S
D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects; D015653:Cystectomy; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000209:etiology / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology / Q000601:surgery; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D012175:Retinoblastoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide