Severe memory impairment in a child with bihippocampal injury after status epilepticus.
Epilepsy may contribute to memory deficits in children, but these deficits are generally mild. We describe the neuropsychological profile of a female who had prolonged status epilepticus at 5 years of age, and then developed temporal lobe epilepsy. Brain magnetic resonance imaging 1 month after the onset of status epilepticus showed marked bilateral hippocampal atrophy that seemed disproportionate to the mild cortico-subcortical atrophy. At the age of 7 years, this child had cognitive impairment (an IQ of 62), which particularly affected her memory. This included short-term memory, and immediate and delayed memory deficits for verbal and visual materials that had a profound impact on everyday life. This observation demonstrates that severe status epilepticus can cause predominant bilateral hippocampal atrophy in childhood. In contrast with children who develop such damage after anoxia, this may result in general cognitive impairment but also in more severe episodic memory deficit.
Jambaqué
Isabelle
I
Laboratoire Cognition et Développement, Institut de Psychologie, Université Paris Descartes, Paris V, CNRS UMR 8605, 92774 Boulogne Billancourt, France. isabelle.jambaque@univ-paris5.fr
Hertz-Pannier
Lucie
L
Mikaeloff
Yann
Y
Martins
Sylvie
S
Peudenier
Sylviane
S
Dulac
Olivier
O
Chiron
Catherine
C
D001284:Atrophy / Q000473:pathology; D002648:Child; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D013226:Status Epilepticus / Q000150:complications* / Q000473:pathology*; D014888:Wechsler Scales