[Expression of Cyt C in brain of rats poisoned by tetramine].
OBJECTIVE
To investigate the evidence for the judgement on legal cases of intoxication by tetramine.


METHODS
Fifty rats given tetramine by lavage were sacrificed at different time after intoxication. The expression of Cyt C was detected by immunohistochemistry, and the reasults were assessed by an image analysis system.


RESULTS
There was a slight expression of Cyt C in control group. In intoxication group the expression of Cyt C increased after the rats were given tetramine for 30 minutes; it reached the peak at 24 hours after intoxication and kept up the level for 3 days, then it began to decrease and returned to the control level in 10 days.


CONCLUSIONS
The regular change of Cyt C expression might be a useful sign for assessment in legal cases of intoxication by tetramine.
Li
Bin
B
Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Chen
Wei-jia
WJ
Yan
Hong-tao
HT
Wu
Jing-jie
JJ
Jin
Bo
B
Liao
Zhi-gang
ZG
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001952:Bridged-Ring Compounds / Q000506:poisoning*; D045304:Cytochromes c / Q000096:biosynthesis*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D011041:Poisoning / Q000175:diagnosis / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D001952:Bridged-Ring Compounds; D045304:Cytochromes c; C010349:tetramethylenedisulfotetramine