Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.
Vijaykumar
Dange
D
Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. dvijayku@hotmail.com
Sprengeler
Paul A
PA
Shaghafi
Michael
M
Spencer
Jeffrey R
JR
Katz
Brad A
BA
Yu
Christine
C
Rai
Roopa
R
Young
Wendy B
WB
Schultz
Brian
B
Janc
James
J
D015949:Factor IXa / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D011720:Pyrazoles / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*
D011720:Pyrazoles; D015842:Serine Proteinase Inhibitors; D015949:Factor IXa