Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole.
In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.
Quan
Hua
H
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
Cao
Ying-Ying
YY
Xu
Zheng
Z
Zhao
Jing-Xia
JX
Gao
Ping-Hui
PH
Qin
Xiao-Feng
XF
Jiang
Yuan-Ying
YY
D000935:Antifungal Agents / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D025141:Drug Resistance, Fungal / Q000187:drug effects / Q000235:genetics*; D004357:Drug Synergism; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D001599:Berberine; D015725:Fluconazole