[Experimental model of Walker 256 carcinosarcoma in rats bladder].
OBJECTIVE
An animal model to study bladder tumor with Walker 256.


METHODS
Bladders rats Wistar was catheterized via urethra and compression lesion of the wall bladder was realized with a little clamping after laparotomy. One total of the 0,3 ml suspension with 3 x 10(5) cels viable of the carcinosarcoma was instilled into each bladder. The animals were sacrificed after eight and 13 days.


RESULTS
The index of tumor incidence was 100% and the average of surviving was 14,5 days.


CONCLUSIONS
The model studied was efficient and will can to take subsidy the study experimental in treatment of local invasive bladder cancer.
Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará.
Conceição Aparecida
CA
Dornelas
Paulo Roberto Carvalho de
PR
Almeida
Germana Lopes do
GL
Nascimento
Erika Bastos
EB
Lima
Manoel Odorico de
MO
Moraes
D000818:Animals; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging / Q000473:pathology*; D002404:Catheterization; D004195:Disease Models, Animal; D005260:Female; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000293:injuries; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*