Rosai-Dorfman disease presenting as bilateral eyelid swellings.
OBJECTIVE
To report a case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) in an extranodal site with unusual presentation.


METHODS
A 19-year-old girl presented with bilateral upper eyelid swellings of 2 years duration due to tumor. The masses were excised and sent for histopathological examination. Microscopic examination revealed similar features in both masses in the form of a collection of large histiocytic cells showing emperipolesis (lymphocytophagocytosis). The histiocytic cells stained positively with S-100 protein and CD68. The background comprised small lymphocytes and plasma cells. Based on the overall features a diagnosis of sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease was made.


CONCLUSIONS
The present case highlights one of the forms in which extranodal Rosai-Dorfman disease can manifest itself. It is important to keep this differential diagnosis in mind whenever such histopathological features are encountered.
Department of Histopathology, Hussain Makki Juma Centre for Specialised Surgeries, Kuwait. sanjayjogai@rediffmail.com
Sanjay
S
Jogai
Labiba
L
Temmim
Abdullah
A
Al-Baghli
Aaron Olaolu
AO
Adesina
D000328:Adult; D003937:Diagnosis, Differential; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome