Modeling of drug release from celecoxib-PVP-meglumine amorphous systems.
An empirical assessment of drug release from amorphous systems of celecoxib (CEL), poly(vinyl pyrrolidone) (PVP), and meglumine (MEG) was performed and compared with that for its crystalline form. CEL-PVP (4:1 w/w) binary and CEL-PVP-MEG (7:2:1 w/w) ternary amorphous systems provided higher drug dissolution. Mathematical modeling of drug release data was found to best fit the Hixson-Crowell release model. The biphasic drug release during a 6-h duration exhibited higher release kinetics in the first phase due to the presence of drug in amorphous form. The release kinetics subdued in the latter phase due to ongoing devitrification process in amorphous systems. A comprehensive understanding of drug release from amorphous systems will accentuate the rationalized design of amorphous drug delivery systems.
Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab - 160 062, India.
Piyush
P
Gupta
Arvind K
AK
Bansal
D000068579:Celecoxib; D003460:Crystallization; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry; D004355:Drug Stability; D008536:Meglumine / Q000737:chemistry*; D008956:Models, Chemical; D010592:Pharmaceutic Aids / Q000737:chemistry*; D010599:Pharmacokinetics; D011205:Povidone / Q000737:chemistry*; D011208:Powders; D011720:Pyrazoles / Q000737:chemistry*; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry*
D016861:Cyclooxygenase Inhibitors; D010592:Pharmaceutic Aids; D011208:Powders; D011720:Pyrazoles; D013449:Sulfonamides; D008536:Meglumine; D011205:Povidone; D000068579:Celecoxib