Subcutaneous panniculitis-like T-cell lymphoma: successful initial treatment with prednisolone and cyclosporin A.
A case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is reported. A 27-year-old man presented with fever and abdominal swelling. His laboratory examination revealed pancytopenia and liver dysfunction. The diagnosis of SPTCL was made by biopsy based on thickened subcutaneous tissue. In addition, bone marrow specimen showed a hemophagocytosis syndrome (HPS). Methylprednisolone pulse therapy was initiated followed by prednisolone (60 mg/day) and cyclosporin A (150 mg/day). He responded to the treatment and remained asymptomatic for at least for 6 months. Our results suggest that a trial of cyclosporin A is warranted in patients with SPTCL complicated by HPS.
Department of Internal Medicine, Osaka City General Hospital, Osaka.
Yuka
Y
Tsukamoto
Yoshioka
Y
Katsunobu
Yoko
Y
Omura
Isseki
I
Maeda
Manabu
M
Hirai
Hirofumi
H
Teshima
Yoshio
Y
Konishi
Takeshi
T
Inoue
Toshihiko
T
Sato
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000188:drug therapy; D016399:Lymphoma, T-Cell / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D015434:Panniculitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage*; D012074:Remission Induction
D018931:Antineoplastic Agents, Hormonal; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone