Characterization of bulk properties of nanofibrous scaffolds from nanomechanical properties of single nanofibers.
This article presents a method of characterizing the macromechanical properties of polymer nanofibrous scaffolds based on the nanomechanical properties obtained for a single nanofiber. Here, we use the example of a poly(L-lactic acid) (PLLA) nanofibrous scaffold that can be used for tissue engineering application. The elastic modulus of a single nanofiber obtained previously from a nanoscale three-point bend test performed using atomic force microscopy was used to model the elastic modulus and elastic collapse stress of the bulk scaffold. Various open-cell solid models are examined for the modeling of bulk scaffold behavior.
Tan
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EP
Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576.
Lim
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CT
D001672:Biocompatible Materials; D019344:Lactic Acid; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008961:Models, Structural; D036103:Nanotechnology; D011091:Polyesters; D011108:Polymers
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)