The eureka enzyme: the discovery of DNA polymerase.
The identification and partial purification by Arthur Kornberg and his colleagues in 1956 of an enzyme - DNA polymerase I of Escherichia coli - that catalysed the stable incorporation of deoxyribonucleotides into DNA in vitro came as a surprise. At the time, most scientists in the field believed that DNA synthesis was too complicated to be accurately reflected outside the living cell.
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 79503-9072, USA. errol.friedberg@utsouthwestern.edu
Errol C
EC
Friedberg
D001671:Biochemistry / Q000266:history*; D004256:DNA Polymerase I / Q000266:history*; D004926:Escherichia coli / Q000201:enzymology; D049673:History, 20th Century; D008967:Molecular Biology / Q000266:history*
D004256:DNA Polymerase I