An unexpected connection: lymph node lymphangiogenesis and dendritic cell migration.
Migration of antigen-presenting dendritic cells (DCs) through lymphatics to draining lymph nodes (LNs) represents a key step in the initiation of an adaptive immune response. In this issue of Immunity, provide the first evidence that remodeling of the lymphatic network within LNs and in peripheral tissues enhances DC migration after immunization and that this process depends on the presence of B cells within the LN.
Halin
Cornelia
C
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, Wolfgang-Pauli-Str. 10, CH-8093 Zurich, Switzerland.
Detmar
Michael
M
D000818:Animals; D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000502:physiology; D002465:Cell Movement; D003713:Dendritic Cells / Q000502:physiology; D008198:Lymph Nodes / Q000276:immunology* / Q000378:metabolism*; D042583:Lymphangiogenesis / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A