Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates human immunodeficiency virus type 1.
Reduction of transmission of human immunodeficiency virus type 1 (HIV-1) through human milk is needed. Alkyl sulfates such as sodium dodecyl sulfate (SDS) are microbicidal against HIV-1 at low concentrations, have little to no toxicity, and are inexpensive. The authors have reported that treatment of HIV-1-infected human milk with < or = 1% (10 mg/mL) SDS for 10 minutes inactivates cell-free and cell-associated virus. The SDS can be removed with a commercially available resin after treatment without recovery of viral infectivity. In this article, the authors report results of selective biochemical analyses (ie, protein, immunoglobulins, lipids, cells, and electrolytes) of human milk subjected to SDS treatment and removal. The SDS treatment or removal had no significant effects on the milk components studied. Therefore, the use of alkyl sulfate microbicides to treat milk from HIV-1-positive women may be a simple, practical, and nutritionally sound way to prevent or reduce transmission of HIV-1 while still feeding with mother's own milk.
Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, USA.
Sandra Urdaneta
SU
Hartmann
Brian
B
Wigdahl
Elizabeth B
EB
Neely
Cheston M
CM
Berlin
Cara-Lynne
CL
Schengrund
Hung-Mo
HM
Lin
Mary K
MK
Howett
D005260:Female; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008895:Milk, Human / Q000737:chemistry / Q000821:virology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*
D012967:Sodium Dodecyl Sulfate