Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae).
The ethanol extract of a biannual medicinal herb, Youngia japonica (commonly known as Oriental hawk's beard) was reported previously to have potent antiviral activity against respiratory syncytial virus (RSV) cultured in HEp-2 cells. Three anti-microbial agents, namely 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, and luteolin-7-O-glucoside were subsequently purified and chemically characterized from the ethanol extract of Youngia japonica. The two dicaffeoylquinic acids exhibited prominent anti-RSV with 50% inhibitory concentration (IC50) of 0.5 microg/ml in vitro. Luteolin-7-O-glucoside together with the two dicaffeoylquinic acids were also manifested to have some antibacterial activity towards the causal agents of food-borne disease, namely Vibrio cholerae and Vibrio parahaemolyticus at the concentration of 2mg/ml. Bacillus cereus was sensitive to 3,4-dicaffeoylquinic acid and 3,5-dicaffeoylquinic acid only, but not to luteolin-7-O-glucoside.
Department of Biology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Linda S M
LS
Ooi
Hua
H
Wang
Zhendan
Z
He
Vincent E C
VE
Ooi
D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002726:Chlorogenic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D047311:Luteolin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000254:growth & development
D000998:Antiviral Agents; D005960:Glucosides; D002726:Chlorogenic Acid; C066408:luteolin-7-glucoside; C478100:3,4-di-O-caffeoylquinic acid; D047311:Luteolin; C100434:3,5-dicaffeoylquinic acid