[Clinical analysis of 1,142 hospitalized cantonese patients with nasopharyngeal carcinoma].
OBJECTIVE
Few large-scale epidemiologic investigations of nasopharyngeal carcinoma (NPC) at high incidence region in Guangdong province were reported in recent 20 years. This study was to summarize clinical data of a population of hospitalized Cantonese NPC patients,analyze the epidemiologic characteristics of NPC in the high incidence region, and provide references for the prevention and treatment of NPC.


METHODS
Clinical data of 1 142 Cantonese NPC patients, hospitalized in Cancer Center of Sun Yat-sen University between Jan. 1998 and Aug. 2000, were collected according to well-designed forms and statistically analyzed.


RESULTS
The morbidity of NPC in Cantonese showed obvious family clustering: 21.9% of the patients had family history of cancer, and 12.3% had family history of NPC. Moreover, the family clustering feature was more obvious in the population from the region with higher incidence of NPC. The positive rate of VCA/IgA antibody was 90.0%, and that of EA/IgA antibody was 74.5%; the titers were positively related to tumor burden. Early diagnostic rate of NPC was about 30%.


CONCLUSIONS
NPC patients in Cantonese population have obvious family and territorial clustering. High positive rates of VCA/IgA and EA/IgA antibodies are helpful for early diagnosis of NPC.
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China.
Su-Mei
SM
Cao
Xiang
X
Guo
Ning-Wei
NW
Li
Yan-Qun
YQ
Xiang
Ming-Huang
MH
Hong
Hua-Qing
HQ
Min
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000276:immunology; D036022:Capsid Proteins / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000473:pathology; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000473:pathology; D009367:Neoplasm Staging
D000956:Antigens, Viral; D036022:Capsid Proteins; C041788:Epstein-Barr viral capsid antigen; C033305:Epstein-Barr virus early antigen; D007070:Immunoglobulin A