Topical application of mitomycin C in combination with dexamethasone: effective delay of myringotomy closure.
The object of this study was to investigate the efficacy of topical mitomycin C (MMC) in combination with subsequent topical dexamethasone to prolong the patency of myringotomies. Bilateral instrumental myringotomies were performed in 12 rats. On both sides, a solution of MMC (2 mg/ml) was applied to the intact tympanic membrane for ten minutes before myringotomy. Dexamethasone (4 mg/ml) was applied to one tympanic membrane of each animal at days 3, 6, 9 and 14. Tympanic membranes were observed weekly for a total of 9 weeks. The mean healing period was found to be 17.5 days (range 4.5-45.5 days) in the group with MMC alone, and 32 days (range 17.5-59.5 days) in the group MMC + dexamethasone. The difference was significant. A combination of topical MMC and subsequent dexamethasone did delay the healing rate of myringotomies in rat tympanic membranes longer than MMC alone.
Kaftan
Holger
H
Department of Otorhinolaryngology and Head and Neck Surgery, University of Greifswald, Greifswald, Germany. h.kaftan@web.de
Hosemann
Werner
W
D000287:Administration, Topical; D000477:Alkylating Agents / Q000008:administration & dosage*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D008876:Middle Ear Ventilation; D016685:Mitomycin / Q000008:administration & dosage*; D010034:Otitis Media with Effusion / Q000601:surgery; D051381:Rats; D011917:Rats, Inbred Lew; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects*
D000477:Alkylating Agents; D000893:Anti-Inflammatory Agents; D016685:Mitomycin; D003907:Dexamethasone