Gamete imprinting: setting epigenetic patterns for the next generation.
The acquisition of genomic DNA methylation patterns, including those important for development, begins in the germ line. In particular, imprinted genes are differentially marked in the developing male and female germ cells to ensure parent-of-origin-specific expression in the offspring. Abnormalities in imprints are associated with perturbations in growth, placental function, neurobehavioural processes and carcinogenesis. Based, for the most part, on data from the well-characterised mouse model, the present review will describe recent studies on the timing and mechanisms underlying the acquisition and maintenance of DNA methylation patterns in gametes and early embryos, as well as the consequences of altering these patterns.
McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada. jacquetta.trasler@mcgill.ca
Jacquetta M
JM
Trasler
D000818:Animals; D035843:Biomedical Research; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000502:physiology; D044127:Epigenesis, Genetic; D005260:Female; D018392:Genomic Imprinting; D005854:Germ Cells / Q000502:physiology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D013234:Stem Cells / Q000502:physiology