Granulomas induced by subcutaneous injection of leuprorelin acetate.
Leuprorelin acetate, a chemotherapeutic agent used to treat prostate cancer, is a synthetic luteinizing hormone-releasing hormone (LHRH) agonist. We report a 75-year-old man who presented with several large subcutaneous nodules at the site of leuprorelin acetate injections for his prostatic cancer. A biopsy of the nodules disclosed epithelioid granulomatous inflammation and resulted in a diagnosis of drug-induced granulomatous reaction to leuprorelin acetate.
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. ryoko-s@kagoderma.com
Ryoko
R
Sakamoto
Yuko
Y
Higashi
Kentaro
K
Mera
Takuro
T
Kanekura
Tamotsu
T
Kanzaki
D000005:Abdomen; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006099:Granuloma / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology
D018931:Antineoplastic Agents, Hormonal; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide