[Fatal asthma in childhod preventable by recognizing risk factors and presenting features].
A 6-year-old child known with asthma died from an asthma attack after having had severe dyspnoea which lasted for 1 day. She had been having an average of 40 salbutamol 'puffs' each day for 1 month. For the preceding 8 months she had been having just over half this number as well as fluticasone. A 13-year-old girl died of an asthma attack. Three weeks previously she had been dyspnoeic and had taken salbutamol and prednisone as well as amoxicillin at a later stage. Each year between 8 and 10 children die of an acute exacerbation of asthma in the Netherlands. There are 2 different types of acute fatal asthma: a slow type (I) and a rapidly progressing type (II). In type I there is progressive obstruction of the airways due to oedema, mucous and spasm. Type II predominantly consists of bronchoconstriction. The main risk factors are previous hospital admission with asthma and inadequate maintenance medication. Effective maintenance therapywith the correct dosage ofinhalational corticosteroids administered correctly can probably stop the potentially fatal asthma type II from developing.
Erasmus MC-Sophia Kinderziekenhuis, Dr. Molewaterplein 60, 3015 GJ Rotterdam.
S C A T
SC
Verbruggen
L J A
LJ
Corel
H A W M
HA
Tiddens
K F M
KF
Joosten
M
M
de Hoog
D000293:Adolescent; D000420:Albuterol / Q000627:therapeutic use; D000730:Androstadienes / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000453:epidemiology / Q000401:mortality* / Q000517:prevention & control*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002648:Child; D003645:Death, Sudden / Q000453:epidemiology / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D000068298:Fluticasone; D006801:Humans; D009426:Netherlands / Q000453:epidemiology
D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D000068298:Fluticasone; D000420:Albuterol