Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children.
BACKGROUND
Cardiac surgery with cardiopulmonary bypass (CPB) induces substantial release of IL-10, indicating increased Th2 cell response. Therefore, in this study, we wanted to verify if this response is due to CPB or surgical trauma, and to study its relation to postoperative effusions and edema (POEE) in children.


METHODS
Th1/Th2 reaction was monitored in children undergoing cardiovascular surgery with (n = 75) and without CPB (n = 29).


RESULTS
Surgery with CPB compared to surgery without CPB induced a transient shift towards Th2. Elevated Th2 response was related to increased vascular permeability and POEE.


CONCLUSIONS
The immune suppression/Th2 response is typical for CPB, and at intermediate level is tolerable but at high level could be adverse for the patients.
Department of Pediatric Cardiology, Heart Center Leipzig, University Leipzig, Germany.
József
J
Bocsi
Margit
M
Richter
Jörg
J
Hambsch
Markus J
MJ
Barten
Ingo
I
Dähnert
Peter
P
Schneider
Attila
A
Tárnok
D000293:Adolescent; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D004487:Edema / Q000097:blood / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007371:Interferon-gamma / Q000032:analysis; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000032:analysis; D010490:Pericardial Effusion / Q000097:blood / Q000276:immunology; D010996:Pleural Effusion / Q000097:blood / Q000276:immunology; D011183:Postoperative Complications / Q000097:blood / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
D007074:Immunoglobulin G; D016753:Interleukin-10; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma