Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia.
OBJECTIVE
To determine if levels of the glial-derived proteins S100beta and glial acidic fibrillary protein (GFAP) and the pro- and antiapoptotic proteins p53 and Bcl-2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder.


METHODS
Levels of S100beta, GFAP, p53 and Bcl-2 were measured in cortex (Brodmann's Areas (BAs) 9, 10, 46 and 40) of control subjects and subjects with schizophrenia, bipolar 1 disorder and in the cortex of rats treated with haloperidol or lithium using protein-specific antibodies and western blot analysis.


RESULTS
Levels of S100beta were decreased in BA 9 and increased in BA 40 from subjects with bipolar 1 disorder. Levels of this protein were not altered in other CNS regions, in schizophrenia or in the cortex of rats treated with haloperidol or lithium. No changes in levels of the other three proteins were detected across diagnoses.


CONCLUSIONS
Regionally selective changes in cortical S100beta may be associated with the pathology of bipolar 1 disorder and may reflect derangements in neuronal death or survival.
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute of Victoria, The University of Melbourne, Parkville, Victoria, Australia. bdean_mhri@iprimus.com.au
Brian
B
Dean
Laura
L
Gray
Elizabeth
E
Scarr
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology; D051017:Apoptosis Regulatory Proteins / Q000032:analysis*; D000072224:Bcl-2-Like Protein 11; D001714:Bipolar Disorder / Q000473:pathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis*; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D012307:Risk Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis*; D012559:Schizophrenia / Q000473:pathology*
D051017:Apoptosis Regulatory Proteins; C000606775:BCL2L11 protein, human; D000072224:Bcl-2-Like Protein 11; C000606778:Bcl2l11 protein, rat; D008565:Membrane Proteins; D009414:Nerve Growth Factors; C414742:P53AIP1 protein, human; D011518:Proto-Oncogene Proteins; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins