Endometrial cancer arising in both horns of didelphys uterus in a Down's syndrome woman.
BACKGROUND
There are only few reports of endometrial cancer arising in patients with uterine malformations. Down's syndrome is characterized by a reduced risk of solid tumors, and there are no reports about its correlation with uterine malformations.


METHODS
An endometrial adenocarcinoma arising in both horns of a didelphys uterus of a Down's syndrome woman.


CONCLUSIONS
Uterine malformations and genetical disorders may cause a delayed diagnosis of gynecological cancers. Gynecological examination in asymptomatic patients and differential diagnosis in abnormal uterine bleeding patients should be considered.
Division of Gynecologic Oncology, Catholic University of Sacred Heart, Campobasso, Italy.
Francesco
F
Fanfani
Anna
A
Fagotti
Gennaro
G
Restaino
Massimiliano
M
Guerriero
Giovanni
G
Scambia
D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D016889:Endometrial Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D014599:Uterus / Q000002:abnormalities*