The ribosome-recycling step: consensus or controversy?
Ribosome recycling, the last step in translation, is now accepted as an essential process for prokaryotes. In 2005, three laboratories showed that ribosome-recycling factor (RRF) and elongation factor G (EF-G) cause dissociation of ribosomes into subunits, solving the long-standing problem of how this essential step of translation occurs. However, there remains ongoing controversy regarding the other actions of RRF and EF-G during ribosome recycling. We propose that the available data are consistent with the notion that RRF and EF-G not only split ribosomes into subunits but also participate directly in the release of deacylated tRNA and mRNA for the next round of translation.
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Go
G
Hirokawa
Natalia
N
Demeshkina
Nobuhiro
N
Iwakura
Hideko
H
Kaji
Akira
A
Kaji
D001692:Biological Transport; D011485:Protein Binding; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism*
D021122:Protein Subunits; D012333:RNA, Messenger; D012343:RNA, Transfer