Lactic acid fermentation in cell-recycle membrane bioreactor.
Traditional lactic acid fermentation suffers from low productivity and low product purity. Cell-recycle fermentation has become one of the methods to obtain high cell density, which results in higher productivity. Lactic acid fermentation was investigated in a cell-recycle membrane bioreactor at higher substrate concentrations of 100 and 120 g/dm3. A maximum cell density of 145 g/dm3 and a maximum productivity of 34 g/(dm3.h) were achieved in cell-recycle fermentation. In spite of complete consumption of substrate, there was a continuous increase in cell density in cell-recycle fermentation. Control of cell density in cell-recycle fermentation was attempted by cell bleeding and reduction in yeast extract concentration.
Department of Chemical Engineering, Indian Institute of Technology, Madras, Chennai 600 036, India.
B
B
Choudhury
T
T
Swaminathan
D018533:Biomass; D019149:Bioreactors / Q000382:microbiology*; D001709:Biotechnology / Q000379:methods*; D002455:Cell Division; D002457:Cell Extracts / Q000737:chemistry; D005285:Fermentation; D005374:Filtration; D005947:Glucose / Q000378:metabolism; D019344:Lactic Acid / Q000096:biosynthesis*; D052201:Lacticaseibacillus rhamnosus / Q000254:growth & development / Q000378:metabolism; D008567:Membranes, Artificial; D015003:Yeasts / Q000737:chemistry
D002457:Cell Extracts; D008567:Membranes, Artificial; D019344:Lactic Acid; D005947:Glucose