The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing.
Wound healing involves a number of cellular and molecular events, many of which are controlled by soluble growth factors. In the process of healing, hepatocyte growth factor, a cytokine known to act as mitogen, motogen, and morphogen, has been postulated to play multiple roles during several stages of this complex biological process. Produced primarily by stromal fibroblasts, hepatocyte growth factor regulates angiogenesis, vascular permeability, cell migration, matrix deposition and degradation, and other biological processes. The current article discusses recent progress in understanding the multiple roles played by this growth factor in tissue repair.
Conway
Kevin
K
Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom. kevinconway@doctors.org.uk
Price
Patricia
P
Harding
Keith G
KG
Jiang
Wen G
WG
D017228:Hepatocyte Growth Factor / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D015394:Molecular Structure; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology; D015398:Signal Transduction; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
D017978:Receptors, Growth Factor; D017228:Hepatocyte Growth Factor; C081092:HGF activator; D012697:Serine Endopeptidases