Life of a clathrin coat: insights from clathrin and AP structures.
Membrane sorting between secretory and endocytic organelles is predominantly controlled by small carrier vesicles or tubules that have specific protein coats on their cytoplasmic surfaces. Clathrin-clathrin-adaptor coats function in many steps of intracellular transport and are the most extensively studied of all transport-vesicle coats. In recent years, the determination of structures of clathrin assemblies by electron microscopy, of domains of clathrin and of its adaptors has improved our understanding of the molecular mechanisms of clathrin-coated-vesicle assembly and disassembly.
Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK.
Melissa A
MA
Edeling
Corinne
C
Smith
David
D
Owen
D033942:Adaptor Proteins, Vesicular Transport / Q000737:chemistry* / Q000648:ultrastructure*; D000818:Animals; D002966:Clathrin / Q000737:chemistry* / Q000648:ultrastructure*; D022163:Clathrin-Coated Vesicles / Q000648:ultrastructure*; D004705:Endocytosis; D006801:Humans; D011487:Protein Conformation
D033942:Adaptor Proteins, Vesicular Transport; D002966:Clathrin