Respiratory rhythm generation during gasping depends on persistent sodium current.
In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.
Paton
Julian F R
JF
Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK. Julian.F.R.Paton@Bristol.ac.uk
Abdala
Ana P L
AP
Koizumi
Hidehiko
H
Smith
Jeffrey C
JC
St-John
Walter M
WM
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology*; D001933:Brain Stem / Q000187:drug effects / Q000254:growth & development*; D000860:Hypoxia / Q000503:physiopathology; D001239:Inhalation / Q000187:drug effects / Q000502:physiology*; D009415:Nerve Net / Q000187:drug effects / Q000254:growth & development*; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D010507:Periodicity; D051381:Rats; D012125:Respiratory Center / Q000187:drug effects / Q000254:growth & development*; D026941:Sodium Channel Blockers / Q000494:pharmacology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D026941:Sodium Channel Blockers; D015222:Sodium Channels