Severe case of Mediterranean spotted fever in Greece with predominantly neurological features.
Rickettsia conorii is endemic in Greece, though only a few cases of infection have been published to date. The case of a 58-year-old man from northern Greece with a severe form of Mediterranean spotted fever and rapid neurological deterioration is presented here. The patient received antibiotic treatment with doxycycline, showing immediate clinical and laboratory improvement. Diagnosis was confirmed later, during the second week after disease onset, by detection of elevated titres of IgM and IgG antibodies against R. conorii using an indirect immunofluorescence assay.
Tzavella
Konstantina
K
Hatzizisis
Ioannis S
IS
Vakali
Aikaterini
A
Mandraveli
Kalliopi
K
Zioutas
Dimitrios
D
Alexiou-Daniel
Stella
S
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood*; D001907:Boutonneuse Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology; D004318:Doxycycline / Q000627:therapeutic use; D006115:Greece; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology; D020114:Rickettsia conorii / Q000276:immunology*; D012720:Severity of Illness Index
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004318:Doxycycline