Low-grade systemic inflammation profile, unrelated to homocysteinemia, in obese children.
To investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (tHcy), an independent risk factor for adult atherosclerosis, in comparison to 42 prepubertal lean children (PLC). The main observations in POC were higher CRP levels compared to PLC, positive association of SAA levels to CRP levels, no association of CRP or SAA levels to tHcy levels. Thus, in POC, positively interrelated to each other, elevated CRP and unaltered SAA levels reveal a unique profile of the CLGSI, not explaining homocysteinemia-induced risk for future atherosclerosis.
Hormone Laboratory, 2nd Clinic for Obstetrics and Gynecology, Aretaieon Hospital, University of Athens, Greece. eveconom@otenet.gr
Emanuel V
EV
Economou
Ariadne V
AV
Malamitsi-Puchner
Christos P
CP
Pitsavos
Evangelia E
EE
Kouskouni
Ioanna
I
Magaziotou-Elefsinioti
George
G
Creatsas
D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D007249:Inflammation / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000276:immunology; D012307:Risk Factors; D000685:Serum Amyloid A Protein / Q000378:metabolism
D015415:Biomarkers; D000685:Serum Amyloid A Protein; D006710:Homocysteine; D002097:C-Reactive Protein