Biochemical microarrays for studying chemical biology interaction: DiscoveryDot technology.
DiscoveryDot is a novel solution-phase technology for chemical compound microarrays which has been validated for several targets (e.g. serine proteases, cysteine proteases, metalloproteinases, histone deacetylases, phosphatases and various kinases) of significance for drug discovery. The historical context of microarrays and the advantages of the DiscoveryDot technology are highlighted. The success of this chemical microarray technology will provide unprecedented possibility and capability for parallel functional analysis of hundreds of thousands of chemical compounds.
Horiuchi
Kurumi Y
KY
Reaction Biology Corporation, One Great Valley Parkway, Suite 8, Malvern, PA 19355, USA.
Wang
Yuan
Y
Ma
Haiching
H
D000336:Aerosols / Q000378:metabolism; D046228:Microarray Analysis / Q000379:methods*; D008962:Models, Theoretical; D013678:Technology, Pharmaceutical / Q000379:methods*
D000336:Aerosols