Antipyretics and delirious behavior during febrile illness.
BACKGROUND
The purpose of the present paper was to study the use of antipyretics in children with delirium associated with fever in order to clarify their possible adverse effects.


METHODS
The use of antipyretics was investigated in 26 children with delirious behavior associated with fever. Temporal relation between delirious behavior and the use of antipyretics was recognized in six children.


RESULTS
In four children, delirious behavior was observed soon after administration of antipyretics. The antipyretics used were acetaminophen in two children, mephenamate in one, and diclofenac in one. In the other two children, delirious behavior was observed when body temperature began to fall 1-2 h after administration of antipyretics. The antipyretics used were acetaminophen in one child and mephenamate in one.


CONCLUSIONS
A temporal relationship between antipyretics and delirious behavior was observed in some patients with febrile delirium. This suggests that antipyretics can be a trigger of delirium.
Okumura
Akihisa
A
Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan. okumura@med.nagoya-u.ac.jp
Fukumoto
Yukiko
Y
Hayakawa
Fumio
F
Nakano
Takashi
T
Higuchi
Kazuo
K
Kamiya
Hitoshi
H
Watanabe
Kazuyoshi
K
Morishima
Tsuneo
T
D000082:Acetaminophen / Q000009:adverse effects; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003693:Delirium / Q000209:etiology*; D004008:Diclofenac / Q000009:adverse effects; D005260:Female; D005334:Fever / Q000150:complications*; D006801:Humans; D008297:Male
D018712:Analgesics, Non-Narcotic; D004008:Diclofenac; D000082:Acetaminophen