Making digit patterns in the vertebrate limb.
The vertebrate limb has been a premier model for studying pattern formation - a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models.
Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. c.a.tickle@dundee.ac.uk
Cheryll
C
Tickle
D000818:Animals; D019521:Body Patterning; D047108:Embryonic Development / Q000235:genetics; D005121:Extremities / Q000196:embryology*; D006801:Humans