Abnormality of mismatch negativity in response to tone omission in dyslexic adults.
Evidence of abnormalities in the perception of rapidly presented sounds in dyslexia has been interpreted as evidence of a prolonged time window within which sounds can influence the perception of temporally surrounding sounds. We recorded the magnetic mismatch negativity (MMNm) to infrequent tone omissions in a group of six dyslexic adults and six IQ and age-matched controls. An MMNm is only elicited in response to a complete stimulus omission when successive inputs fall within the temporal window of integration (stimulus onset asynchrony (SOA) approximately 160 ms). No MMNm responses were recorded in either experimental group when stimuli were presented at SOAs falling just outside the temporal window of integration (SOA = 175 ms). However, while presentation rates of 100 ms resulted in MMNm responses for all control participants, the same stimulus omissions elicited an MMNm response in only one of the six dyslexic participants. These results cannot support the hypothesis of a prolonged time window of integration, but rather indicate auditory grouping deficits in the dyslexic population.
The Wellcome Trust Laboratory for MEG Studies, Neurosciences Research Institute, Aston University, Aston Triangle, Birmingham, B4 7ET, UK. A.E.Fisher@aston.ac.uk
Alison E
AE
Fisher
Gareth R
GR
Barnes
Arjan
A
Hillebrand
Ian E
IE
Holliday
Caroline
C
Witton
Ian L
IL
Richards
D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology*; D004410:Dyslexia / Q000175:diagnosis* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D016555:Matched-Pair Analysis; D008606:Mental Processes / Q000502:physiology; D046709:Pattern Recognition, Physiological / Q000502:physiology*; D012016:Reference Values