Regulation of Notch signalling by endocytosis and endosomal sorting.
Cell-cell signalling is an essential process in the formation of multicellular organisms. Notch is the receptor of an evolutionarily conserved signalling pathway regulating numerous developmental decisions. Indeed, its misregulation is linked to multiple developmental and physiological disorders. Notch and its ligands are distributed widely throughout development, yet Notch activity is highly controlled and restricted in time and space. Recent advances have highlighted that endocytosis followed by endosomal sorting of both the Notch receptor and its ligands is an essential mechanism by which Notch-mediated signalling is developmentally controlled.
Le Borgne
Roland
R
CNRS UMR 6061, Faculté de Médecine, 2 avenue du Professeur Léon Bernard, CS 34317, 35043 Rennes Cedex, France. roland.leborgne@univ-rennes1.fr
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport; D051880:Receptors, Notch / Q000378:metabolism / Q000502:physiology*; D000072099:Serrate-Jagged Proteins; D015398:Signal Transduction / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D002135:Calcium-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; D000072099:Serrate-Jagged Proteins; C064045:delta protein; C086488:lag-2 protein, C elegans