Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media.
The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).
Laboratory of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands.
Debby
D
Bogaert
Emma
E
Holmlund
Mika
M
Lahdenkari
Ronald
R
de Groot
Terhi
T
Kilpi
Peter W M
PW
Hermans
Helena
H
Kayhty
D000208:Acute Disease; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000276:immunology; D002353:Carrier State / Q000276:immunology* / Q000382:microbiology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D010033:Otitis Media / Q000276:immunology* / Q000382:microbiology; D011008:Pneumococcal Infections / Q000276:immunology* / Q000382:microbiology; D022242:Pneumococcal Vaccines; D012697:Serine Endopeptidases / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D022242:Pneumococcal Vaccines; D012697:Serine Endopeptidases