Evaluation of nootropic potential of Ocimum sanctum Linn. in mice.
Dementia is one of the age related mental problems and a characteristic symptom of various neurodegenerative disorders including Alzheimer's disease. Certain drugs like diazepam, barbiturates and alcohol disrupt learning and memory in animals and man. However, a new class of drugs known as nootropic agents is now used in situations where there is organic disorder in learning abilities. The present work was undertaken to assess the potential of O. sanctum extract as a nootropic and anti-amnesic agent in mice. Aqueous extract of dried whole plant of O. sanctum ameliorated the amnesic effect of scopolamine (0.4 mg/kg), diazepam (1 mg/kg) and aging induced memory deficits in mice. Elevated plus maze and passive avoidance paradigm served as the exteroceptive behavioral models. O. sanctum extract decreased transfer latency and increased step down latency, when compared to control (piracetam treated), scopolamine and aged groups of mice significantly. O. sanctum preparations could of beneficial in the treatment of cognitive disorders such as dementia and Alzheimer's disease.
Department of Pharmaceutical Sciences, Guru Jambheshwar University, Hisar, India. amanjoshi17@yahoo.com
Hanumanthachar
H
Joshi
Milind
M
Parle
D000544:Alzheimer Disease / Q000188:drug therapy; D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D003704:Dementia / Q000188:drug therapy; D003975:Diazepam; D004305:Dose-Response Relationship, Drug; D006801:Humans; D018782:Maze Learning / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D018697:Nootropic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D031339:Ocimum / Q000737:chemistry*; D008517:Phytotherapy; D010889:Piracetam / Q000494:pharmacology; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D012601:Scopolamine / Q000494:pharmacology
D018697:Nootropic Agents; D010936:Plant Extracts; D012601:Scopolamine; D003975:Diazepam; D010889:Piracetam