[Analytical interference in determination of procalcitonin by PCT-Q (Brahms)].
Procalcitonin (PCT) is a biological marker of infection. We present the cas of a patient who has presented a high concentration of PCT with PCT-Q test (Brahms). At the same time, the concentration of CRP is remained low, which is no physiological. Then, PCT concentration has been determinated with an automatic system (Kryptor-Brahms) and finded at low than 0.5 microg/l. Brahms company has searched an analytical interference: human anti-mouse antibodies (HAMA) were positive. If PCT concentration stay a marker of infection for the most part, this case show that biologists have to keep in mind that immunological assays remain submitted to interferences.
Fédération de biologie clinique, HIA Clermont-Tonnerre 29240 Brest-Armées, France. biochimie@hopital-armees-brest.fr
C
C
Désidéri-Vaillant
Y
Y
Rouby
N
N
Cardon
U
U
Vinsonneau
J-P
JP
Laborde
D001331:Automation; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002637:Chest Pain / Q000097:blood; D005260:Female; D006801:Humans; D007239:Infections / Q000175:diagnosis; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*; D015203:Reproducibility of Results
D015415:Biomarkers; C000606589:CALCA protein, human; C000606590:Calca protein, mouse; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide