Baylis-Hillman adducts with molluscicidal activity against Biomphalaria glabrata.
The molluscicidal activities of ten Baylis-Hillman adducts against Biomphalaria glabrata (Say) snails, the intermediate host of schistosomiasis, have been determined. Nine of these compounds showed significant molluscicidal activity against B. glabrata, falling below the threshold of 100 microg ml(-1) set for potential molluscicidal activity by the World Health Organisation. Among these compounds, 3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile had the highest activity, with LC(50) = 6.64 microg ml(-1).
Departamento de Química, Universidade Federal da Paraíba, Campus I, João Pessoa, PB, Brazil. mlaav@quimica.ufpb.br
Mário Laa
ML
Vasconcellos
Tania Ms
TM
Silva
Celso A
CA
Camara
Rodrigo M
RM
Martins
Kelly M
KM
Lacerda
Horacimone M
HM
Lopes
Vera Lp
VL
Pereira
Rodrigo Oma
RO
de Souza
Lívia Tc
LT
Crespo
D000818:Animals; D001592:Benzyl Alcohols / Q000737:chemistry*; D001700:Biomphalaria; D008975:Molluscacides / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*
C510493:3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile; D001592:Benzyl Alcohols; D008975:Molluscacides; D009570:Nitriles