Interference of antibiotics in the growth curves of oral streptococci.
The growth curve interference (GCI) induced by different antibiotics was studied using reference strains of oral streptococci. This parameter may prove to be useful in preventing subacute endocarditis of odontological origin in high-risk patients. The growth curves using different concentrations of antibiotics and with an initial optical density (OD) of 0.05 +/- 0.01 were observed until an OD of 0.9-1.0 was reached. The GCI was defined as the lowest concentration of antibiotic that modified the growth curve with respect to a control without antibiotic. The GCI values were then compared with the minimum inhibitory concentration (MIC) values. In all cases, interference in the growth curves was at least one concentration lower than the MIC in a time ranging from 4-6 h.
Castillo
Ana
A
Department of Microbiology, School of Medicine and Dentistry, University of Granada, Spain. anamc@ugr.es
Liébana
José
J
López
Encarnación
E
Baca
Pilar
P
Liébana
José M
JM
Liébana
María J
MJ
Castillo
Francisca
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012463:Saliva / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents