[Sequelae of hypertenson: kidney disease].
Nephropathy is one of the frequent sequelae of hypertension. Arterial hypertension causes both arterial and capillary changes in the kidneys as well as development of interstitial fibrosis. Systemic or intraglomerular pressure increase leads to albuminuria and proteinuria, which in turn contributes to further damage of the kidneys. Impairment of the kidneys due to hypertension can ultimately result in terminal renal insufficiency necessitating dialysis. Metabolic factors such as hyperlipidemia, hyperuricemia, hyperhomocysteinemia, and insulin resistance can aggravate renal lesions. Effective lowering of blood pressure in conjunction with management of the metabolic risk factors is decisive for prevention of chronic kidney disease, which in turn must be considered a factor involved in exacerbation of the hypertension.
Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universität Wien, Wien. walter.hoerl@meduniwien.ac.at
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D000419:Albuminuria / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D006977:Hypertension, Renal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006978:Hypertension, Renovascular / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D007677:Kidney Function Tests; D011507:Proteinuria / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control
D000959:Antihypertensive Agents