Infectious and noninfectious endophthalmitis after intravitreal high-dosage triamcinolone acetonide.
OBJECTIVE
To evaluate the rate of infectious and noninfectious endophthalmitis after intravitreal injection of a high-dosage of triamcinolone acetonide.


METHODS
Clinical interventional case-series study.


METHODS
The study included 1135 intravitreal injections of approximately 20 mg triamcinolone performed for 915 eyes with diabetic macular edema (n = 257), exudative age-related macular degeneration (n = 561), retinal vein occlusions (n = 82), and other reasons. Among the injections were 220 reinjections. Triamcinolone was filtered to remove the solvent agent. Mean follow-up was 8.1 +/- 7.4 months.


RESULTS
In none of the eyes, signs of an infectious or noninfectious endophthalmitis were observed such as noncrystalline hypopyon, cellular infiltration, or amorphous opacification of the vitreous, retinal infiltration, or pain. One patient developed infectious endophthalmitis 2 days after a traumatic rupture of a previous corneoscleral cataract incision.


CONCLUSIONS
The rate of infectious or noninfectious endophthalmitis after an intravitreal high-dosage triamcinolone injection may be approximately 1:1000, if the solvent agent was removed.
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, Ruprecht-Karls-University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Jost.Jonas@augen.ma.uni-heidelberg.de
Jost B
JB
Jonas
Ingrid
I
Kreissig
Ulrich H
UH
Spandau
Bjoern
B
Harder
D003930:Diabetic Retinopathy / Q000188:drug therapy; D009877:Endophthalmitis / Q000453:epidemiology* / Q000382:microbiology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D007267:Injections; D008268:Macular Degeneration / Q000188:drug therapy; D008269:Macular Edema / Q000188:drug therapy; D011310:Preservatives, Pharmaceutical; D012170:Retinal Vein Occlusion / Q000188:drug therapy; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014822:Vitreous Body / Q000187:drug effects*
D005938:Glucocorticoids; D011310:Preservatives, Pharmaceutical; D014222:Triamcinolone Acetonide