Shared components of mitochondrial and peroxisomal division.
Mitochondria and peroxisomes are ubiquitous subcellular organelles, which are highly dynamic and display large plasticity. Recent studies have led to the surprising finding that both organelles share components of their division machinery, namely the dynamin-related protein DLP1/Drp1 and hFis1, which recruits DLP1/Drp1 to the organelle membranes. This review addresses the current state of knowledge concerning the dynamics and fission of peroxisomes, especially in relation to mitochondrial morphology and division in mammalian cells.
Schrader
Michael
M
Department of Cell Biology and Cell Pathology, University of Marburg, Robert-Koch Str. 6, 35037 Marburg, Germany. schrader@mailer.uni-marburg.de
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D020675:Peroxisomes / Q000378:metabolism*
D024101:Mitochondrial Proteins