Elevated coagulation factor VIII, postoperative thrombosis and flap failure in late breast reconstruction with a free TRAM flap: a case report.
Only a few studies have sought to establish whether an underlying coagulation disorder might predispose a patient to thrombosis or coincide with flap failure in the context of free flap surgery. Here, we report a case of both intra- and postoperative arterial anastomotic thromboses and late flap failure due to venous thrombosis after late breast reconstruction with a TRAM flap, in which laboratory evaluation revealed elevated levels of coagulation factor VIII (FVIII). High FVIII concentrations have recently been cited as an independent and dose-dependent risk factor for thromboembolism.
Department of Surgery, Gävle-Sandviken Central Hospital and Centre for Research and Development, Uppsala University, Gävleborg, 5-801 88 Gävle, Sweden.
Patrik
P
Höijer
Eija
E
Olsson
D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016462:Mammaplasty; D008875:Middle Aged; D011183:Postoperative Complications; D013524:Surgical Flaps / Q000098:blood supply*; D019851:Thrombophilia / Q000150:complications*; D013927:Thrombosis / Q000209:etiology; D020246:Venous Thrombosis / Q000209:etiology
D005169:Factor VIII