A case of nodular scleroderma.
Nodular scleroderma is a rare complication of systemic sclerosis; the pathogenetic implications are still unknown, although many factors are supposed to play a role in lesion development. We report the case of a young woman suffering from systemic sclerosis, who developed nodular lesions during therapeutic management with D-penicillamine and plasmapheresis. In order to better understand the essence of this disease, we examined all the possible pathogenetic mechanisms that could be implicated in nodular lesion development.
Department of Dermatological Sciences, University of Florence, Italy.
Lucilla
L
Melani
Marzia
M
Caproni
Carla
C
Cardinali
Emiliano
E
Antiga
Elisabetta
E
Bernacchi
Emiliano
E
Schincaglia
Paolo
P
Fabbri
D000328:Adult; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D010396:Penicillamine / Q000627:therapeutic use; D010956:Plasmapheresis / Q000379:methods; D018570:Risk Assessment; D012594:Scleroderma, Localized / Q000473:pathology* / Q000628:therapy*; D012595:Scleroderma, Systemic / Q000188:drug therapy / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome
D010396:Penicillamine