Cross-correlated relaxation between H1' chemical shift anisotropy and H1'-H2' dipolar relaxation mechanisms in ribonucleosides: application to the characterization of their anomeric configuration.
Cross-correlated nuclear spin relaxation between 1H chemical shift anisotropy (CSA) and 1H-1H dipolar relaxation mechanisms in ribonucleosides in solution phase are observed and used to identify their anomeric configuration. Only alpha-ribonucleosides showed the presence of cross-correlated spin relaxation through differential spin-lattice relaxation (T1) of the H1' doublet. Dependence of the magnitude and the orientation of the H1' CSA tensor values on the glycosidic torsion angle and the fast time-scale internal motions present in the ribose moiety play a significant role in the characterization of the anomeric configuration of the nucleosides via cross-correlated relaxation.
Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, USA.
Kumar
K
Pichumani
Tilak
T
Chandra
Xiang
X
Zou
Kenneth L
KL
Brown
D016880:Anisotropy; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D012263:Ribonucleosides / Q000737:chemistry*; D013237:Stereoisomerism
D012263:Ribonucleosides