Detection of serum autoantibodies against AT₁A-receptor during the development of the four types of hypertensive rat models.
Using two-kidney one-clip renal hypertensive (2K1C group), stress-induced hypertensive (neural group), DOCA-salt treated hypertensive (DOCA group) and spontaneously hypertensive rats (SHR group), to investigate the change in AT(1A)-receptor autoantibodies (AT(1A)-AAs) during the development of the four types of hypertension. The biological activities of AT(1A)-AAs were examined. It was shown that the frequency of occurrence and titres of AT(1A)-AAs increased significantly during the development of hypertension. In the four hypertensive groups studied, the occurrence of AT(1A)-AAs was most prominent in SHR, 2K1C and neural groups. The biological effects of AT(1A)-AAs were shown to increase the beating frequency of cultured neonatal myocardial and vascular contractile tension. It is suggested that autoimmune mechanisms are involved the pathogenesis of different types of hypertension and the AT(1A)-AAs may be one of the mechanisms leading to cardiac hypertrophy.
Department of Toxicology, the Second Military Medical University, Shanghai 200433, China.
Rong-Fang
RF
Chen
Jin
J
Wang
Xiang-Ying
XY
Jiao
Hui-Rong
HR
Liu
Rong-Rui
RR
Zhao
Jian-Ming
JM
Zhi
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D003900:Desoxycorticosterone / Q000008:administration & dosage; D006973:Hypertension / Q000145:classification / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D013312:Stress, Physiological / Q000502:physiology
D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1; D003900:Desoxycorticosterone