Bayesian dynamic modeling of latent trait distributions.
Studies of latent traits often collect data for multiple items measuring different aspects of the trait. For such data, it is common to consider models in which the different items are manifestations of a normal latent variable, which depends on covariates through a linear regression model. This article proposes a flexible Bayesian alternative in which the unknown latent variable density can change dynamically in location and shape across levels of a predictor. Scale mixtures of underlying normals are used in order to model flexibly the measurement errors and allow mixed categorical and continuous scales. A dynamic mixture of Dirichlet processes is used to characterize the latent response distributions. Posterior computation proceeds via a Markov chain Monte Carlo algorithm, with predictive densities used as a basis for inferences and evaluation of model fit. The methods are illustrated using data from a study of DNA damage in response to oxidative stress.
Biostatistics Branch, National Institute of Environmental Health Sciences, MD A3-03, Research Triangle Park, NC 27709, USA. dunson1@niehs.nih.gov
David B
DB
Dunson
D000465:Algorithms; D001499:Bayes Theorem; D001699:Biometry / Q000379:methods; D002460:Cell Line; D004249:DNA Damage; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D008390:Markov Chains; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D018384:Oxidative Stress; D018709:Statistics, Nonparametric
D006861:Hydrogen Peroxide