Electrocortical effects of MDMA are potentiated by acoustic stimulation in rats.
BACKGROUND
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is known for its toxicological, psychopathological and abuse potential. Some environmental conditions, e.g. acoustic stimulation typical of the "rave scene" can influence the toxicity of this drug.


RESULTS
We investigated the effects of low doses of MDMA in vivo using Wistar rats in the absence of acoustic stimulation (white noise; 95 Db) demonstrating that ecstasy is able to induce a significant activation (reduction of Electrocortical total power) of the telencephalic cortex that spontaneously reverts in the absence of sensorial stimuli, whereas it persists for several days if, in addition to MDMA, the animals are exposed to acoustic stimulation.


CONCLUSIONS
Our data demonstrate that low doses of MDMA are able to reduce electrocortical total power, and that this effect is potentiated by sensorial stimuli commonly present in certain environments, such as rave parties.
Iannone
Michelangelo
M
Section of Pharmacology, CNR-Institute of Neurological Science, Roccelletta di Borgia, Catanzaro, Italy. m.iannone@isn.cnr.it
Bulotta
Stefania
S
Paolino
Donatella
D
Zito
Maria Cristina
MC
Gratteri
Santo
S
Costanzo
Francesco S
FS
Rotiroti
Domenicantonio
D
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000379:methods; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D051381:Rats; D013057:Spectrum Analysis; D013997:Time Factors
D006213:Hallucinogens; D018817:N-Methyl-3,4-methylenedioxyamphetamine