Predictors of relapse to harmful alcohol after orthotopic liver transplantation.
BACKGROUND
End-stage alcoholic liver disease (ALD) is a common indication for liver transplantation. Outcomes may be limited by return to harmful drinking. Previous studies have identified few predictors of drinking relapse.


OBJECTIVE
This study examined novel postulated predictors of relapse to drinking.


METHODS
The case notes of all patients transplanted for ALD at the Royal Prince Alfred Hospital from 1987-2004 were reviewed. Pre-transplant characteristics were rated by a psychiatrist independent of the transplant team, blind to the outcome. Outcomes were rated by a second independent alcohol treatment specialist also blind to the pre-transplant ratings.


RESULTS
Of 100 patients, 6 died before discharge from hospital, 4 had <6 months follow-up, 18 relapsed to harmful drinking, 10 drank below harmful levels, and 62 remained abstinent after a mean of 5.6 years follow-up. Univariate analyses identified six potential pre-transplant predictors of return to harmful drinking. These were a diagnosis of mental illness (of which all cases were of depression), the lack of a stable partner, grams per day consumed in the years before assessment for transplant, reliance on 'family or friends' for post-transplant support, tobacco consumption at time of assessment, and lack of insight into the alcohol aetiology. Duration of pre-transplant abstinence and social class by occupation did not predict relapse. A multivariate model based on the above characteristics correctly predicted 89% of the outcomes.


CONCLUSIONS
A model based on readily defined behaviours and psychosocial factors predicted relapse to harmful drinking after transplant for ALD. This model may improve assessment and post-transplant management of patients with advanced ALD.
Alcohol Problems Service, Royal Edinburgh Hospital, Scotland.
Maria
M
Kelly
Jonathan
J
Chick
Robert
R
Gribble
Margaret
M
Gleeson
Mathew
M
Holton
Julie
J
Winstanley
Geoffrey W
GW
McCaughan
Paul S
PS
Haber
D000437:Alcoholism / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000523:psychology / Q000601:surgery; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000523:psychology / Q000601:surgery; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015588:Observer Variation; D011237:Predictive Value of Tests; D012008:Recurrence; D012044:Regression Analysis; D012931:Social Environment; D016019:Survival Analysis; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology