Management of a pregnant patient with Graves' disease complicated by propylthiouracil induced agranulocytosis.
Relapse and exacerbation of Graves' disease during pregnancy is rare, and thionamide induced agranulocytosis is an uncommon side effect. We report a case of a pregnant woman in her 24th week of gestation that experienced a relapse of Graves' disease that was complicated by propylthiouracil induced agranulocytosis. Following the discontinuation of propylthiouracil and administration of a broad-spectrum of antibiotics, agranulocytosis subsided within 10 days. A total thyroidectomy to avoid any future relapse was planned and a short course of a beta-adrenergic blocker and Lugol solution were prescribed before the operation. At the 28th week of gestation, a total thyroidectomy was performed without complications and thyroxine replacement therapy was commenced. At the 40th week of gestation, labor was induced and a 3,370 g healthy male infant was born without clinical features of thyrotoxicosis. We report herein on the patient and the treatment options for this rare and complicated case.
Department of Internal Medicine, Catholic University of Daegu School of Medicine, Korea.
Yoon-Young
YY
Cho
Ho Sang
HS
Shon
Hyun Dae
HD
Yoon
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced / Q000150:complications*; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000628:therapy*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D011441:Propylthiouracil / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D013965:Thyroidectomy
D013956:Antithyroid Agents; D011441:Propylthiouracil