alpha-fetoprotein expression in a dedifferentiated liposarcoma.
Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.
Bosco
Martino
M
Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
Allia
Elena
E
Coindre
Jean-Michel
JM
Odasso
Chiara
C
Pagani
Alberto
A
Pacchioni
Donatella
D
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism; D017809:Fatal Outcome; D015870:Gene Expression; D006801:Humans; D007124:Immunoenzyme Techniques; D008080:Liposarcoma / Q000097:blood* / Q000473:pathology / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012186:Retroperitoneal Neoplasms / Q000378:metabolism / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012983:Soft Tissue Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000235:genetics / Q000378:metabolism*
D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D000509:alpha-Fetoproteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4