Synthesis of fluorinated polybrominated diphenyl ethers (F-PBDEs) as internal standards for environmental analysis.
Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their wide-spread use as flame retardants. Their structural similarity to other halogenated organic pollutants, for example polychlorinated biphenyls (PCBs), has led to speculation that they may have similar toxicological properties and effects. Recent focus on PBDEs as possible priority pollutants has also led to an increasing need for reference standards of PBDEs for toxicological studies and for environmental analysis. In this work we synthesized a series of fluorinated PBDEs (F-PBDEs) which can be used as possible internal standards, as an alternative to high-cost alternatives, such as the (13)C-labelled analogues. F-PBDEs have been synthesized by using different coupling reactions and by bromination of fluorinated starting materials.
Liu
Huiling
H
Chiron AS, Stiklestadveien 1, N-7041 Trondheim, Norway. huiling.liu@chiron.no
Skålvoll
Anja
A
Reijerink
Gaby S
GS
Luthe
Gregor
G
Johansen
Jon E
JE
D004784:Environmental Monitoring; D005411:Flame Retardants / Q000032:analysis*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000032:analysis / Q000138:chemical synthesis; D011075:Polybrominated Biphenyls / Q000032:analysis* / Q000138:chemical synthesis*; D012015:Reference Standards
D005411:Flame Retardants; D006845:Hydrocarbons, Fluorinated; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls