131I-chTNT radioimmunotherapy of 43 patients with advanced lung cancer.
The treatment of advanced lung cancer remains a major challenge in clinical medicine, justifying an urgent need for new therapeutic approaches. In a rather unique international collaboration, 43 patients with advanced lung cancer were treated using iodine-131-labeled tumor necrosis therapy chimeric antibody (131I-chTNT).


METHODS
Patients were treated either with intravenous (i.v.) infusion (n = 22), intratumoral injection using a computer tomography (CT)-guided catheter (n = 16), or combination i.v. and intratumoral infusion (n = 5). All patients, regardless of route of administration, received 2 doses of 131I-chTNT on days 1 and 14.


RESULTS
The results showed that of those patients receiving i.v. injection alone, 2 achieved partial response (PR) (9%), 16 had stable disease (73%), and 4 progressed (18%). Of those patients receiving intratumoral injection only, 1 had a complete response (CR) (6%), 8 achieved PR (50%), 7 had stable disease (44%), and none (0%) progressed. Finally, of those patients receiving both i.v. and intratumoral administration, 1 had a CR (20%), 1 achieved PR (20%), 2 had stable disease (40%), and 1 (20%) showed progression.


CONCLUSIONS
These promising results demonstrate that sufficient doses of radiolabeled antibody can be safely delivered to tumors to cause significant therapeutic effects in advanced lung cancer.
Nanjing Pulmonary Hospital, Nanjing, China.
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L
Yu
Dian Wen
DW
Ju
Wenping
W
Chen
Tian
T
Li
Zhaoqiang
Z
Xu
Changying
C
Jiang
Shaoliang
S
Chen
Qun
Q
Tao
Dan
D
Ye
Peisheng
P
Hu
Leslie A
LA
Khawli
Clive R
CR
Taylor
Alan L
AL
Epstein
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use* / Q000633:toxicity; D008175:Lung Neoplasms / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016499:Radioimmunotherapy / Q000379:methods; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D007457:Iodine Radioisotopes; D014409:Tumor Necrosis Factor-alpha