Chemoenzymatic syntheses of iGb3 and Gb3.
Efficient chemoenzymatic syntheses of iGb3 and Gb3 have been developed. Isoglobotrihexose and globotrihexose were enzymatically synthesized by a three-enzyme system in both solid and solution phases. Then iGb3 and Gb3 were chemically synthesized by coupling of the corresponding trisaccharides with lipid.
Yao
Qingjia
Q
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Song
Jing
J
Xia
Chengfeng
C
Zhang
Wenpeng
W
Wang
Peng George
PG
D000818:Animals; D002240:Carbohydrate Sequence; D005699:Galactosylceramides / Q000737:chemistry / Q000494:pharmacology; D005915:Globosides / Q000138:chemical synthesis* / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D014281:Trihexosylceramides / Q000138:chemical synthesis* / Q000378:metabolism; D014312:Trisaccharides
D005699:Galactosylceramides; D005915:Globosides; D014281:Trihexosylceramides; D014312:Trisaccharides; C514780:globotrihexosylceramide; C514781:isoglobotrihexosylceramide; C018549:globotriaosylceramide; D010727:Phosphoric Diester Hydrolases; C060071:UDP-galactose hydrolase; C103873:KRN 7000