[Role of the cerebellum in the control of distal motor activities in patients with akinetic-rigid Parkinson disease].
Using f-MRI, we have studied the changes induced by the performance of a complex sequential motor task in the cortical areas of nine akinetic PD patients and compared to that of healthy volunteers. Compared with normal subjects, PD patients showed a reduction of activation of motor and SMA areas, an increase of activation of parietal areas and a bilateral activation of cerebellar hemispheres, which are likely to participate in the attempt to recruit parallel motor circuits in order to overcome the striatocortical defective loop.
Dipartimento di Medicina Interna e Clinica Neurologica, UCO di Clinica Neurologica, Sezione di Disturbi Cognitivi, Trieste. moretti@univ.trieste.it
Rita
R
Moretti
Paola
P
Torre
Rodolfo M
RM
Antonello
Maja
M
Ukmar
Giuseppe
G
Cazzato
Gilberto
G
Pizzolato
D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002531:Cerebellum / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D003342:Corpus Striatum / Q000503:physiopathology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D011597:Psychomotor Performance
D000978:Antiparkinson Agents; D007980:Levodopa