Stereoselective synthesis of (E)-alpha,beta-unsaturated esters via carbene-catalyzed redox esterification.
[reaction: see text] Stereoselective, carbene-mediated redox esterification of alkynyl aldehydes provides mild and atom economical access to (E)-configurated, alpha,beta-unsaturated carboxylic esters. The organocatalytic method relies on the generation of activated carboxylates via extended/conjugated umpolung in the presence of catalytic amounts of carbene precursor and base.
Zeitler
Kirsten
K
Institut für Organische Chemie, Universität Regensburg, Universitätsstrasse 31, D-93053 Regensburg, Germany. kirsten.zeitler@chemie.uni-regensburg.de