Ring-opening dynamics of jadomycin A and B and dalomycin T.
[structure: see text] A novel oxazolone ring-opening and interconversion process between the two jadomycin diastereomeric forms has been characterized by NMR spectroscopy. An analogue, dalomycin T, has been isolated for the first time and does not undergo interconversion.
Syvitski
Ray T
RT
College of Pharmacy, 5968 College Street, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5.
Borissow
Charles N
CN
Graham
Cathy L
CL
Jakeman
David L
DL
D007546:Isoquinolines / Q000737:chemistry; D015394:Molecular Structure; D009285:Naphthoquinones; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism
D007546:Isoquinolines; D009285:Naphthoquinones; C514630:dalomycin T; C506597:jadomycin A; C081750:jadomycin B