B cells discriminate the rules of engagement.
How B cells discriminate antigen-receptor-mediated signals in development and navigate critical checkpoints in adaptive immune responses remains poorly resolved. In this issue of Immunity, conditionally ablate the main regulatory subunit of the calcineurin phosphatase complex in B cells to reveal both positive and negative influences on the development of antibody responses and B cell memory.
McHeyzer-Williams
Michael G
MG
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
McHeyzer-Williams
Louise J
LJ
Malherbe
Laurent
L
D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D019703:Calcineurin / Q000235:genetics / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D018858:Germinal Center / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D000955:Antigens, T-Independent; C120817:calcineurin phosphatase; D019703:Calcineurin; D010744:Phosphoric Monoester Hydrolases; D002118:Calcium