alpha-fetoprotein expression in a dedifferentiated liposarcoma.
Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.
Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
Martino
M
Bosco
Elena
E
Allia
Jean-Michel
JM
Coindre
Chiara
C
Odasso
Alberto
A
Pagani
Donatella
D
Pacchioni
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism; D017809:Fatal Outcome; D015870:Gene Expression; D006801:Humans; D007124:Immunoenzyme Techniques; D008080:Liposarcoma / Q000097:blood* / Q000473:pathology / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012186:Retroperitoneal Neoplasms / Q000378:metabolism / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012983:Soft Tissue Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000235:genetics / Q000378:metabolism*
D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D000509:alpha-Fetoproteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4