Imaging signaling processes in platelets.
Unraveling the complex signaling processes regulating platelet adhesion has been a longstanding goal for those in the field of platelet research. Advances in high-speed live cell imaging techniques, taking advantage of developments in the area of fluorescent probe design hold considerable promise for the investigation of the dynamic signaling processes governing platelet activation and function, both physiologically and pathologically. This review broadly covers the application of existing imaging techniques to the investigation of platelet function and examines new developments in the area of live cell imaging that may have future applications in the field.
Nesbitt
Warwick S
WS
The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Prahran, Victoria 3181, Australia.
Jackson
Shaun P
SP
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D003952:Diagnostic Imaging / Q000379:methods*; D005456:Fluorescent Dyes; D006801:Humans; D015398:Signal Transduction
D005456:Fluorescent Dyes