Goat milk oligosaccharides are anti-inflammatory in rats with hapten-induced colitis.
Oligosaccharides are included among the anti-inflammatory components of milk because of their prebiotic properties and their capacity to act as receptors of microorganisms. Here the intestinal anti-inflammatory effect of goat milk oligosaccharides (O) was assessed in trinitrobenzenesulfonic (T) acid-induced colitis in rats. Rats were randomly assigned to three different groups. Two groups (T and OS) of colitic rats and a control group (C) were studied. Group OS received 500 mg/(kg.d) of goat milk oligosaccharides orally, starting 2 d before the colitis induction until d 6, and groups T and C received the vehicle. When compared with the T group, the OS group showed decreased anorexia and body weight loss; reduced bowel wall thickening and longitudinal extension of necrotic lesions; downregulated colonic expression of interleukin 1beta, inducible nitric oxide synthase, cyclooxygenase 2, and mucin 3; and increased trefoil factor 3. Thus, goat milk oligosaccharides have anti-inflammatory effects in rats with experimental colitis and may be useful in the management of inflammatory bowel disease.
Daddaoua
Abdelali
A
Department of Biochemistry and Molecular Biology II, University of Granada, Spain.
Puerta
Victor
V
Requena
Pilar
P
Martínez-Férez
Antonio
A
Guadix
Emilia
E
de Medina
Fermín Sánchez
FS
Zarzuelo
Antonio
A
Suárez
María Dolores
MD
Boza
Julio José
JJ
Martínez-Augustin
Olga
O
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003092:Colitis / Q000139:chemically induced / Q000276:immunology*; D003106:Colon / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D006041:Goats; D006241:Haptens; D007375:Interleukin-1 / Q000235:genetics; D008892:Milk / Q000737:chemistry*; D055263:Mucin-3; D009077:Mucins / Q000235:genetics; D052247:Nitric Oxide Synthase Type II / Q000235:genetics; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D000893:Anti-Inflammatory Agents; D006241:Haptens; D007375:Interleukin-1; C524651:Muc3 protein, rat; D055263:Mucin-3; D009077:Mucins; D009844:Oligosaccharides; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2