Use and abuse of hydrogen breath tests.
Hydrogen breath tests are widely used to explore the pathophysiology of functional gastrointestinal disorders. Small intestinal bacterial overgrowth and carbohydrate malabsorption are disorders detected by these tests that have been proposed to be of great importance for symptoms in, for instance, irritable bowel syndrome. However, conclusions drawn from these studies are highly controversial and divergent results exist. There is also an extensive use of these tests in clinical practice with difficulties regarding interpretation of the tests and sometimes erroneous conclusions. The limitations and pitfalls of these tests will be reviewed in this article, and hopefully the occasional abuse of these tests can be turned into proper clinical and scientific use instead in the future.
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, S-41345 Göteborg, Sweden. magnus.simren@medicine.gu.se
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D001419:Bacteria / Q000254:growth & development; D001424:Bacterial Infections / Q000175:diagnosis; D001944:Breath Tests / Q000379:methods*; D004040:Dietary Carbohydrates / Q000493:pharmacokinetics; D005767:Gastrointestinal Diseases / Q000175:diagnosis*; D006801:Humans; D006859:Hydrogen / Q000032:analysis*; D007421:Intestine, Small / Q000382:microbiology; D008286:Malabsorption Syndromes / Q000175:diagnosis
D004040:Dietary Carbohydrates; D006859:Hydrogen