Comparison of ruptured plaques in native coronary arteries and in saphenous vein grafts: an intravascular ultrasound study.
Intravascular ultrasound (IVUS) has been used to describe ruptured plaques in saphenous vein grafts (SVGs) and native coronary arteries. We compared clinical, angiographic, and IVUS features of ruptured atherosclerotic plaques in SVGs and native coronary arteries. We identified 95 plaque ruptures in 76 SVGs in 73 patients. These lesions and patients were matched with 95 lesions and patients from a database of 468 native artery ruptures. The matching criterion was IVUS mean reference lumen area. Patients with ruptured SVG plaques were older (68.4 +/- 10.1 vs 65.0 +/- 10.6 years, p = 0.021), more often had hypercholesterolemia (92% vs 74%, p = 0.015) and hypertension (78% vs 62%, p = 0.059), and more often had a history of a remote myocardial infarction (57% vs 32%, p = 0.002). In contrast, anginal symptoms were similar in the 2 groups (70% to 75% of each group had an acute coronary syndrome). Most (90% to 95%) ruptured plaques in each group were classified as angiographically complex. However, ruptured SVG lesions more often had an angiographically visible intimal flap (71% vs 38%, p <0.001). More than 70% of lesions in the 2 groups had positive arterial remodeling by IVUS, but there was a tendency for a higher remodeling index in ruptured plaque SVG lesions (1.18 +/- 0.30 vs 1.11 +/- 0.20, p = 0.085). The site of the initial tear occurred mainly (in approximately 70%) at the plaque shoulders in the 2 groups. In conclusion, although patients with SVG plaque ruptures are older and have more co-morbidities, the clinical presentation and angiographic and IVUS features are remarkably similar to those of native artery plaque ruptures.
Cardiovascular Research Institute/Medstar Research Institute, Washington Hospital Center, Washington, DC.
Jerzy
J
Pregowski
Pawel
P
Tyczynski
Gary S
GS
Mintz
Sang-Wook
SW
Kim
Adam
A
Witkowski
Ron
R
Waksman
Augusto
A
Pichard
Lowell
L
Satler
Kenneth
K
Kent
Lukasz
L
Kalinczuk
Szymon
S
Bieganski
Patrick
P
Ohlmann
Akiko
A
Maehara
Neil J
NJ
Weissman
D000368:Aged; D015331:Cohort Studies; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology; D012421:Rupture; D012501:Saphenous Vein / Q000000981:diagnostic imaging* / Q000473:pathology / Q000637:transplantation; D017211:Treatment Failure; D018084:Ultrasonography, Interventional