Synthesis of some new substituted triazolo [4,3-a][1,4] benzodiazepine derivatives as potent anticonvulsants.
Novel 8-chloro-6-(2-fluorophenyl)-1-(aryl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines (5a-f) were prepared by treating 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione with various aromatic acid hydrazides. The newly prepared compounds were characterized by spectral analysis. Compounds were tested for anticonvulsant activity. Four of the tested compounds such as 5a, 5d, 5e and 5f exhibited excellent anticonvulsant activity in comparison with standard drug, diazepam.
Narayana
B
B
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri, India. nbadiadka@yahoo.co.uk
Vijaya Raj
K K
KK
Ashalatha
B V
BV
Kumari
N Suchetha
NS
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D015394:Molecular Structure; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D001569:Benzodiazepines