Preconceptional primary human cytomegalovirus infection and risk of congenital infection.
The risk of vertical transmission of human cytomegalovirus (HCMV) was investigated in 14 women who had primary HCMV infection 2-18 weeks before their last menstrual period during 2001-2004. One (8.3%) of 12 newborns examined at birth was found to be subclinically infected. Preconceptional primary HCMV infection has a transmission rate that is significantly higher than that observed in an unselected newborn population but significantly lower than that associated with maternal infection during pregnancy. Although a safe time interval between primary infection and initiation of pregnancy still needs to be defined, documented information can now be provided during counseling.
Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy. mg.revello@smatteo.pv.it
Maria Grazia
MG
Revello
Maurizio
M
Zavattoni
Milena
M
Furione
Elisa
E
Fabbri
Giuseppe
G
Gerna
D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D011296:Prenatal Diagnosis; D018570:Risk Assessment; D012307:Risk Factors
D000914:Antibodies, Viral; D004279:DNA, Viral