The ribosome-recycling step: consensus or controversy?
Ribosome recycling, the last step in translation, is now accepted as an essential process for prokaryotes. In 2005, three laboratories showed that ribosome-recycling factor (RRF) and elongation factor G (EF-G) cause dissociation of ribosomes into subunits, solving the long-standing problem of how this essential step of translation occurs. However, there remains ongoing controversy regarding the other actions of RRF and EF-G during ribosome recycling. We propose that the available data are consistent with the notion that RRF and EF-G not only split ribosomes into subunits but also participate directly in the release of deacylated tRNA and mRNA for the next round of translation.
Hirokawa
Go
G
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Demeshkina
Natalia
N
Iwakura
Nobuhiro
N
Kaji
Hideko
H
Kaji
Akira
A
D001692:Biological Transport; D011485:Protein Binding; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism*
D021122:Protein Subunits; D012333:RNA, Messenger; D012343:RNA, Transfer