Stepwise evolution of the Sec machinery in Proteobacteria.
The Sec machinery facilitates the translocation of proteins across and into biological membranes. In several of the Proteobacteria, this machinery contains accessory features that are not present in any other bacterial division. The genomic distribution of these features in the context of bacterial phylogeny suggests that the Sec machinery has evolved in discrete steps. The canonical Sec machinery was initially supplemented with SecB; subsequently, SecE was extended with two transmembrane segments and, finally, SecM was introduced. The Sec machinery of Escherichia coli and other Enterobacteriales represents the end product of this stepwise evolution.
Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands.
Eli O
EO
van der Sluis
Arnold J M
AJ
Driessen
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000502:physiology; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology; D017124:Conserved Sequence; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology; D019143:Evolution, Molecular; D026901:Membrane Transport Proteins / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D021381:Protein Transport / Q000235:genetics / Q000502:physiology; D020560:Proteobacteria / Q000235:genetics* / Q000502:physiology; D000069816:SEC Translocation Channels; D000081416:SecA Proteins; D016415:Sequence Alignment; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D000069816:SEC Translocation Channels; C057842:SecB protein, Bacteria; C497347:SecM protein, E coli; D014157:Transcription Factors; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins