Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge.
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.
Treviño
Sylvia R
SR
Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21702-5001, USA.
Permenter
Amy R
AR
England
Marilyn J
MJ
Parthasarathy
Narayanan
N
Gibbs
Paul H
PH
Waag
David M
DM
Chanh
Tran C
TC
D000336:Aerosols; D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D042726:Burkholderia mallei / Q000276:immunology*; D005896:Glanders / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C
D000336:Aerosols; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal