Pontine and cerebellar atrophy correlate with clinical disability in SCA2.
Spinocerebellar ataxia type 2 (SCA2) has protean manifestations, and a clinical marker of progression is needed. Although MRI is a promising tool, it is unclear whether the degree of atrophy shown on MRI is correlated with clinical dysfunction. Here the authors used high-resolution volumetric MRI analysis to show that cerebellar and pontine volumes specifically and closely correlate with functional staging scores.
Ying
S H
SH
Johns Hopkins University School of Medicine, Baltimore, MD, USA. sying@dizzy.med.jhu.edu
Choi
S I
SI
Perlman
S L
SL
Baloh
R W
RW
Zee
D S
DS
Toga
A W
AW
D000328:Adult; D000368:Aged; D001284:Atrophy; D016022:Case-Control Studies; D002531:Cerebellum / Q000473:pathology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011149:Pons / Q000473:pathology*; D020754:Spinocerebellar Ataxias / Q000175:diagnosis* / Q000503:physiopathology*