Origin of dengue type 3 viruses associated with the dengue outbreak in Dhaka, Bangladesh, in 2000 and 2001.
Dengue and dengue hemorrhagic fever re-emerged in Bangladesh in 2000 and 2001 and nearly all viruses isolated were dengue type 3. Phylogenetic analyses of the envelope genes of examples of these viruses indicated that they were most closely related to recently emerged dengue type 3 viruses from neighboring Thailand and Myanmar but distinct from those from India and Sri Lanka. Since this strain of dengue virus type 3 had not been associated with unusual patterns of disease in Thailand or Myanmar, it suggested that the outbreak in Bangladesh was due to local factors after the introduction of viruses from countries to the east rather than to the evolution of an unusually virulent strain of virus in Bangladesh.
Podder
Goutam
G
Center for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Breiman
Robert F
RF
Azim
Tasnim
T
Thu
Hlaing Myat
HM
Velathanthiri
Niluka
N
Mai
Le Quynh
le Q
Lowry
Kym
K
Aaskov
John G
JG
D001459:Bangladesh / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000302:isolation & purification*; D004196:Disease Outbreaks; D006801:Humans; D017720:Molecular Epidemiology; D010802:Phylogeny; D019595:Severe Dengue / Q000453:epidemiology / Q000821:virology