Protective and destructive immunity in the periodontium: Part 2--T-cell-mediated immunity in the periodontium.
Based on the results of recent research in the field and Part 1 of this article (in this issue), the present paper will discuss the protective and destructive aspects of the T-cell-mediated adaptive immunity associated with the bacterial virulent factors or antigenic determinants during periodontal pathogenesis. Attention will be focused on: (i) osteoimmunology and periodontal disease; (ii) some molecular techniques developed and applied to identify critical microbial virulence factors or antigens associated with host immunity (with Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis as the model species); and (iii) summarizing the identified virulence factors/antigens associated with periodontal immunity. Thus, further understanding of the molecular mechanisms of the host's T-cell-mediated immune responses and the critical microbial antigens related to disease pathogenesis will facilitate the development of novel therapeutics or protocols for future periodontal treatments.
Teng
Y-T A
YT
Laboratory of Molecular Microbial Immunity, Eastman Department of Dentistry, Eastman Dental Center, Box-683, 625 Elmwood Ave., Rochester, NY 14620, USA. andy_teng@urmc.rochester.edu
D016976:Aggregatibacter actinomycetemcomitans / Q000472:pathogenicity; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D016723:Bone Remodeling / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D010510:Periodontal Diseases / Q000276:immunology* / Q000382:microbiology; D010519:Periodontium / Q000276:immunology*; D016966:Porphyromonas gingivalis / Q000472:pathogenicity; D013601:T-Lymphocytes / Q000276:immunology; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000276:immunology; D037521:Virulence Factors / Q000276:immunology
D000942:Antigens, Bacterial; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D037521:Virulence Factors