[Inhibitive effect to collagen fiber of tanshinone II A in iliac artery following balloon injury in rabbit].
OBJECTIVE
To observe change of iliac artery SMC collagen fiber after balloon injury in tanshinone II A treatment group.


METHODS
Thirty male pure breed New Zealand white rabbits were underwent experimental balloon injury in left iliac artery. Then the rabbits were assigned into treatment group (n = 15) and control group (n = 15). Tanshinone II A sulfonic acid natrium was injected intravenously in treatment group. Saline was venously injected in control group. The balloon injured arteries were harvested in the 7th, 14th, and 28th days after surgery.


RESULTS
Analysis of Collagen fibers staining found that a weak positive staining was shown at the 7th day post-operation in both groups,while a strong positive result was seen at the 14th day in control group. Positive results were even shown at the 14th day in treatment group,but less strong than that of the control. At the 28th day post-operation, collagen fiber staining become weak in treatment group, but increased in the control. Difference between both group in the 28th day post-operation was significant (P = 0.017). Time-dependence tendency of collagen fiber changing was statistically significant (P = 0.005).


CONCLUSIONS
Tanshinone II A suppress stack of extracellular matrix after balloon injury so as to prevent restenosis.
West China Hospital, Sichuan University, Chengdu 610041.
Huaisheng
H
Chen
Bo
B
Long
Yujia
Y
Liang
Yuchang
Y
Chen
Zhi
Z
Zeng
D045784:Abietanes; D000818:Animals; D002404:Catheterization; D003094:Collagen / Q000378:metabolism*; D023903:Coronary Restenosis / Q000517:prevention & control; D004195:Disease Models, Animal; D007083:Iliac Artery / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010616:Phenanthrenes / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D027544:Salvia / Q000737:chemistry*; D017539:Tunica Intima / Q000378:metabolism / Q000473:pathology; D017540:Tunica Media / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D045784:Abietanes; D010616:Phenanthrenes; C021751:tanshinone; D003094:Collagen