Mechanosensitivity and the eye: cells coping with the pressure.
The cells of the various organ systems in humans are subject to mechanical forces to which they must respond. Here the authors review what is known of the ways in which the cells of animals, ranging from the prokaryotic to humans, sense and transduce mechanical forces to respond to such stimuli. In what way this pertains to the eye, especially with respect to axial myopia and the pressure related disease of glaucoma, is then surveyed.
Department of Ophthalmology, Prince of Wales Hospital, High Street, Randwick, NSW 2032, Australia.
J C H
JC
Tan
F B
FB
Kalapesi
M T
MT
Coroneo
D003599:Cytoskeleton / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D005901:Glaucoma / Q000503:physiopathology; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D009216:Myopia / Q000503:physiopathology; D009799:Ocular Physiological Phenomena; D011312:Pressure