Long-term memory for aversive training is impaired in Idua(-/-) mice, a genetic model of mucopolysaccharidosis type I.
Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease that leads to neurodegeneration and neurological deficits, among other pathological and clinical consequences. The aim of the present study was to evaluate neurobehavioral parameters in a genetic mouse model of mucopolysaccharidosis type I (MPS I). During exploration of an open field, adult MPS I (Idua(-/-)) mice showed normal locomotion and anxiety but reduced number of rearings. Idua(-/-) mice performed normally in a novel object recognition memory task and showed normal short-term retention of inhibitory avoidance training. By contrast, long-term retention of inhibitory avoidance was impaired in Idua(-/-) mice. The deficit in inhibitory avoidance memory could not be attributed to reduced footshock reactivity. The results indicate that Idua(-/-) mice present deficits in long-term memory for aversive training and reduced exploratory behavior.
Cellular and Molecular Pharmacology Research Group, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90046-900 Porto Alegre, RS, Brazil.
Gustavo Kellermann
GK
Reolon
Luisa Macedo
LM
Braga
Melissa
M
Camassola
Tatiana
T
Luft
João Antônio Pêgas
JA
Henriques
Nance Beyer
NB
Nardi
Rafael
R
Roesler
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001522:Behavior, Animal; D004195:Disease Models, Animal; D004597:Electroshock / Q000379:methods; D005106:Exploratory Behavior / Q000502:physiology; D007266:Inhibition, Psychological; D008297:Male; D008565:Membrane Proteins / Q000172:deficiency*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008059:Mucopolysaccharidosis I / Q000235:genetics* / Q000503:physiopathology*; D052899:Pore Forming Cytotoxic Proteins; D011930:Reaction Time / Q000235:genetics / Q000528:radiation effects; D021641:Recognition, Psychology / Q000502:physiology; D018709:Statistics, Nonparametric
D008565:Membrane Proteins; C483884:Mpeg1 protein, mouse; D052899:Pore Forming Cytotoxic Proteins