Phototoxic activity of a thiophene polyacetylene from Leuzea carthamoides.
The thiophene polyacetylene (E)-1-[5-(hept-5-en-1,3-diynyl)-2-thienyl]ethan-1,2-diol, isolated from the roots of Leuzea carthamoides, showed phototoxic activity in the assay systems of histidine photo-oxidation, Artemia and Tubifex assays. The effects were compared with the standard photosensitizer xanthotoxin.
Department of Pharmaceutical Botany and Ecology, Charles University, Faculty of Pharmacy, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. vladimir.chobot@faf.cuni.cz
Vladimír
V
Chobot
Jitka
J
Vytlacilová
Lenka
L
Kubicová
Lubomír
L
Opletal
Ludek
L
Jahodár
Into
I
Laakso
Pia
P
Vuorela
D000818:Animals; D001156:Artemia / Q000187:drug effects*; D000431:Ethanol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006639:Histidine / Q000378:metabolism; D007928:Lethal Dose 50; D043843:Leuzea / Q000737:chemistry / Q000633:toxicity*; D008730:Methoxsalen / Q000737:chemistry; D009835:Oligochaeta / Q000187:drug effects*; D010084:Oxidation-Reduction / Q000187:drug effects; D017319:Photosensitizing Agents / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D014466:Ultraviolet Rays
D017319:Photosensitizing Agents; D010936:Plant Extracts; D013876:Thiophenes; C511103:thiophene polyacetylene (E)-1-(5-(hept-5-en-1,3-diynyl)-2-thienyl)ethan-1,2-diol; D000431:Ethanol; D006639:Histidine; D008730:Methoxsalen