Early atherosclerosis in patients with inflammatory bowel disease.
Patients with inflammatory bowel disease (IBD) have an increased risk of thrombotic complications. Arterial and venous system may be involved. Moreover, mesenteric microvascular thrombosis has been hypothesised as a contributing factor in the pathogenesis of IBD. Early atherosclerosis is a clinical feature common to several inflammatory and immunological diseases in which atherothrombotic complication represents one of the most important cause of mortality and morbidity. We investigate the prevalence and the entity of the early stages of vascular disease in a population of IBD patients without the classical cardiovascular risk factors, by measuring the intima-media thickness (IMT) of the common carotid artery. We found that IBD patients have an increased risk of early atherosclerosis than healthy controls as showed by greater values of carotid IMT and that homocysteine levels and age were independently associated with the increased arterial wall thickness.
Department of Internal Medicine, Gastroenterology Unit, Catholic University of Rome, Italy.
A
A
Papa
S
S
Danese
R
R
Urgesi
A
A
Grillo
S
S
Guglielmo
I
I
Roberto
M
M
Bonizzi
L
L
Guidi
I
I
De Vitis
A
A
Santoliquido
G
G
Fedeli
G
G
Gasbarrini
A
A
Gasbarrini
D000367:Age Factors; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D003424:Crohn Disease / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography
D006710:Homocysteine