Cutaneous manifestations of granulocyte colony-stimulating factor.
Granulocyte colony-stimulating factor (GCSF) is a recombinant human growth factor widely used in haematology. It is known to cause cutaneous vasculitis and neutrophilic dermatoses. We present three cases of Sweet's syndrome (SS) associated with GCSF use. Raised GCSF levels have been demonstrated in patients with SS. GCSF is the best understood mechanism by which neutrophil accumulation occurs and shows a dose-dependent effect in provoking SS.
Department of Haematology, King's College Hospital, Denmark Hill, London, UK. jonathanmlwhite@hotmail.com
J M L
JM
White
G J
GJ
Mufti
J R
JR
Salisbury
A W P
AW
du Vivier
D000276:Adjuvants, Immunologic / Q000009:adverse effects; D000328:Adult; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006801:Humans; D000078224:Lenograstim; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects; D016463:Sweet Syndrome / Q000139:chemically induced*
D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000078224:Lenograstim; D000069585:Filgrastim