SARS-CoV infection in a restaurant from palm civet.
Epidemiologic investigations showed that 2 of 4 patients with severe acute respiratory syndrome (SARS) identified in the winter of 2003-2004 were a waitresss at a restaurant in Guangzhou, China, that served palm civets as food and a customer who ate in the restaurant ashort distance from animal cages. All 6 palm civets at the restaurant were positive for SARS-associated coronavirus (SARS-CoV). Partial spike (S) gene sequences of SARS-CoV from the 2 patients were identical to 4 of 5 Sgene viral sequences from palm civets. Phylogenetic analysis showed that SARS-CoV from palm civets in the restaurant was most closely related to animal isolates. SARS cases at the restaurant were the result of recent interspecies transfer from the putative palm civet reservoir, and not the result of continued circulation of SARS-CoV in the human population.
Guangzhou Municipal Center for Disease Control and Prevention, Guangdong, People's Republic of China.
Ming
M
Wang
Meiying
M
Yan
Huifang
H
Xu
Weili
W
Liang
Biao
B
Kan
Bojian
B
Zheng
Honglin
H
Chen
Han
H
Zheng
Yanmei
Y
Xu
Enmin
E
Zhang
Hongxia
H
Wang
Jingrong
J
Ye
Guichang
G
Li
Machao
M
Li
Zhigang
Z
Cui
Yu-Fei
YF
Liu
Rong-Tong
RT
Guo
Xiao-Ning
XN
Liu
Liu-Hua
LH
Zhan
Duan-Hua
DH
Zhou
Ailan
A
Zhao
Rong
R
Hai
Dongzhen
D
Yu
Yi
Y
Guan
Jianguo
J
Xu
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D005516:Food Microbiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D010802:Phylogeny; D012147:Restaurants; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics / Q000302:isolation & purification*; D045169:Severe Acute Respiratory Syndrome / Q000097:blood / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000235:genetics; D045949:Viverridae / Q000821:virology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins