Preconceptional primary human cytomegalovirus infection and risk of congenital infection.
The risk of vertical transmission of human cytomegalovirus (HCMV) was investigated in 14 women who had primary HCMV infection 2-18 weeks before their last menstrual period during 2001-2004. One (8.3%) of 12 newborns examined at birth was found to be subclinically infected. Preconceptional primary HCMV infection has a transmission rate that is significantly higher than that observed in an unselected newborn population but significantly lower than that associated with maternal infection during pregnancy. Although a safe time interval between primary infection and initiation of pregnancy still needs to be defined, documented information can now be provided during counseling.
Revello
Maria Grazia
MG
Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy. mg.revello@smatteo.pv.it
Zavattoni
Maurizio
M
Furione
Milena
M
Fabbri
Elisa
E
Gerna
Giuseppe
G
D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D011296:Prenatal Diagnosis; D018570:Risk Assessment; D012307:Risk Factors
D000914:Antibodies, Viral; D004279:DNA, Viral