Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes.
Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p=0.019) and depressed (p=0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r=-0.37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD.
Cunha
Angelo B M
AB
Department of Neuropsychiatry, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Faixa de Camobi Km 9, 97105 900 Santa Maria, RS, Brazil.
Frey
Benicio N
BN
Andreazza
Ana C
AC
Goi
Júlia D
JD
Rosa
Adriane R
AR
Gonçalves
Carlos A
CA
Santin
Aida
A
Kapczinski
Flavio
F
D000328:Adult; D001714:Bipolar Disorder / Q000378:metabolism* / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D012720:Severity of Illness Index
D019208:Brain-Derived Neurotrophic Factor