L-prolinamide-catalyzed direct nitroso aldol reactions of alpha-branched aldehydes: a distinct regioselectivity from that with L-proline.
The first direct enantioselective N-nitroso aldol reaction of aldehyde with nitrosobenzene catalyzed by an L-prolinamide derivative is presented; the reactions proceed smoothly furnishing the -hydroxyamino carbonyl compounds, the otherwise disfavored products, in good yields with up to 64% ee.
Guo
Hai-Ming
HM
Key Laboratory for Asymmetric Sunthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemsitry, Chinese Academy of Sciences, Chengdu, 610041, China.
Cheng
Li
L
Cun
Lin-Feng
LF
Gong
Liu-Zhu
LZ
Mi
Ai-Qiao
AQ
Jiang
Yao-Zhong
YZ