Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death.
OBJECTIVE
To investigate the prognostic value of peak oxygen pulse, which is the amount of oxygen consumed per heart beat during exercise, and to compare the prognostic value of peak oxygen pulse and maximum oxygen uptake (Vo(2max)) with respect to coronary heart disease (CHD) and overall death.


METHODS
Prospective population-based study based on 1596 men without CHD or the use of beta blockers at baseline.


RESULTS
The risk of CHD was 2.45 (95% CI 1.10 to 5.45) times higher in men with low peak oxygen pulse (< 13.5 ml/beat) than in those with high peak oxygen pulse (> 17.8 ml/beat) after adjustment for age, alcohol consumption, smoking, body mass index, blood pressure, serum lipids, diabetes, family history of CHD and ischaemic ST changes during exercise. During an average follow up of 14 years, 267 men died, 67 of them due to CHD. The respective risk for overall death was 1.79 (95% CI 1.21 to 2.65). The continuous variable Vo(2max) was a stronger risk predictor than peak oxygen pulse for CHD and overall death.


CONCLUSIONS
Assessment of oxygen pulse provides no complementary information to Vo(2max) about cardiorespiratory fitness and prognosis for CHD. The analysis of respiratory gas exchange including the assessment of oxygen pulse during exercise does, however, provide an additional means for defining prognosis for patients with CHD.
Laukkanen
J A
JA
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. jariantero.laukkanen@uku.fi
Kurl
S
S
Salonen
J T
JT
Lakka
T A
TA
Rauramaa
R
R
D015992:Body Mass Index; D002423:Cause of Death; D003327:Coronary Disease / Q000378:metabolism / Q000401:mortality*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology*; D012307:Risk Factors