Histone post-translational modifications and the response to DNA double-strand breaks.
The packaging of DNA into chromatin creates a number of significant barriers to the detection of DNA lesions and their timely and accurate repair. Eukaryotic cells have evolved a number of enzymes that modulate chromatin structure and facilitate DNA repair. Recent research illustrates how nucleosome remodelling enzymes cooperate with both DNA-damage-inducible and constitutive histone modifications to promote many facets of the cellular response to DNA damage.
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Pavillon Marcelle-Coutu, 2950 Chemin Polytechnique, Montreal H3T 1J4, Canada.
Hugo
H
Wurtele
Alain
A
Verreault
D000107:Acetylation; D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D008954:Models, Biological; D009707:Nucleosomes / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational
D018797:Cell Cycle Proteins; D006657:Histones; D009707:Nucleosomes