[Treatment of severe sarcoidosis using TNF-alpha-inhibitor (infliximab)].
Some patients with severe sarcoidosis are resistant to conventional treatment with corticosteroids and cytostatics. We describe a 29-year-old man with histologically verified sarcoidosis and persistent, pronounced enlargement of the peripheral lymph nodes, resistant to treatment with prednisolone and methotrexate. Following treatment with TNF-alpha-inhibitor (infliximab 3 mg/kg body weight), the lymph nodes regressed to normal size and the patient improved clinically. The patient had a total of four infliximab infusions, and the effect has persisted for more than two years.
Milman
Nils
N
H:S Rigshospitalet, Hjertecentret, Medicinsk Afdeling B, Afsnit for Lungetransplantation, og Arhus Universitetshospital, Arhus Sygehus, Lungemedicinsk Afdeling B. milman@rh.dk
Sørensen
Tina Brandt
TB
D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D006801:Humans; D000069285:Infliximab; D008206:Lymphatic Diseases / Q000188:drug therapy*; D008297:Male; D012507:Sarcoidosis / Q000188:drug therapy*; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D000069285:Infliximab