Critical nodes in signalling pathways: insights into insulin action.
Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.
Taniguchi
Cullen M
CM
Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
Emanuelli
Brice
B
Kahn
C Ronald
CR
D000818:Animals; D006801:Humans; D007328:Insulin / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011972:Receptor, Insulin / Q000502:physiology*; D015398:Signal Transduction
D007328:Insulin; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin; D051057:Proto-Oncogene Proteins c-akt