The efficacy of povidone-iodine products against periodontopathic bacteria.
A total of 8 strains of 6 bacterial species, Porphyromonas gingivalis ATCC33277 and TDC286, Actinobacillus actinomycetemcomitans ATCC29523 and JP2, Fusobacterium nucleatum No. 2, Tannerella forsythensis ATCC43937, Prevotella intermedia ATCC25611 and Streptococcus anginosus ATCC33397, were treated with povidone-iodine (PVP-I) gargle (PVP-I: 0.47 and 0.23% w/v) or chlorhexidine gluconate (CHG) gargle (CHG: 0.002% w/v) for 15, 30 or 60 s, after which they were inoculated into various media, cultured and counted for residual bacteria. At both concentrations, PVP-I gargle reduced the viable cell count of all 8 bacterial strains to below the measurable limit within 15 s. By contrast, there were more than 1,000 viable colonies 60 s following treatment with the CHG gargle. The results demonstrate that povidone-iodine gargle has rapid bactericidal activity against the causative bacteria of periodontal disease.
Department of Dentistry and Oral Surgery, Medical School Keio University, Keio, Japan.
Taneaki
T
Nakagawa
Yasuo
Y
Hosaka
Kazuyuki
K
Ishihara
Toru
T
Hiraishi
Soh
S
Sato
Tomohisa
T
Ogawa
Kyuichi
K
Kamoi
D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D016967:Fusobacterium nucleatum / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000187:drug effects; D011206:Povidone-Iodine / Q000494:pharmacology*; D018713:Prevotella intermedia / Q000187:drug effects; D034366:Streptococcus anginosus / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine