Left ventricular apical ballooning: not an uncommon variant of acute myocardial infarction in women.
BACKGROUND
Left ventricular apical ballooning, a new syndrome recently described in Japan, is characterized by chest pain, electrocardiographic changes mimicking acute myocardial infarction, and transient apical dyskinesia with normal coronary arteries. Although several studies have defined the clinical characteristics, the prevalence of this syndrome remains unclear.


OBJECTIVE
This study sought to determine the prevalence of left ventricular apical ballooning syndrome.


METHODS
From January 2002 to September 2004, clinical, echocardiographic, and angiographic data of hospitalization and follow-up were collected from 638 consecutive patients referred to our Heart Institute for primary percutaneous intervention.


RESULTS
Thirteen patients (2%) were diagnosed with transient left ventricular apical ballooning. All but one patient were women, representing a 6% incidence for the female patients with acute myocardial infarction. A triggering factor was identified in eight. One patient died of cardiogenic shock. Left ventricular systolic function recovered completely within 4-5 weeks in the remaining 12 survivors.


CONCLUSIONS
This syndrome is not uncommon and should be considered particularly in female patients presenting with acute myocardial infarction.
Elian
Dan
D
Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel. dani.elian@sheba.health.gov.il
Osherov
Azriel
A
Matetzky
Shlomi
S
Hod
Hanoch
H
Guetta
Victor
V
Feinberg
Micha S
MS
Di Segni
Elio
E
D000368:Aged; D000369:Aged, 80 and over; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000503:physiopathology*; D017023:Coronary Angiography; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology*; D015995:Prevalence; D013577:Syndrome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000503:physiopathology*