Total synthesis, structural revision, and absolute configuration of (-)-clavosolide [corrected] A.
[reaction: see text] Enantioselective synthesis of 3, a revised structure for clavosolide A, was completed. Both (1)H and (13)C NMR spectra of the natural and synthetic compounds were identical, and optical rotation measurements identified the absolute configuration of the natural clavosolide A as [corrected] 3.
Department of Chemistry, Sogang University, Shinsoo-dong 1, Mapo-gu, Seoul 121-742, Korea.
Jung Beom
JB
Son
Si Nae
SN
Kim
Na Yeong
NY
Kim
Duck Hyung
DH
Lee
D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism
D018942:Macrolides; C455699:clavosolide A