[Profile-effect on quality control of Houttuynia cordata injection].
OBJECTIVE
To find corresponding relationship between the fingerprint of Houttuynia cordata injections from different factories and their effects.


METHODS
Houttuynia cordata injections from six different factories were determined by gas chromatography (GC) and gas chromatography-mass spectra (GC-MS), and GC fingerprints were classified by hierarchical clustering. The anti-inflammatory activity of Houttuynia cordata injections was characterized through the rat pleurisy model induced by carrageenin and the mice ear edema model by dimethylbenzene.


RESULTS
The anti-inflammatory effect of the injections from the first class factories on the two model was significant, while those from the second class not. GC-MS analysis result indicated that main effect compounds in Houttuynia cordata injections are methyl n-nonyl ketone, decanoylacetaldehyde, lauryl aldehyde, capryl aldehyde, beta-pinene, beta-linalool, 1-nonanol, 4-terpineol, alpha-terpineol, bornyl acetate, n-decanoic acid and acetic acid, geraniol ester etc.


CONCLUSIONS
There is corresponding relationship between the fingerprint of Houttuynia cordata injections and effect to a certain extent.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. lu_hongmei225@126.com
Hong-mei
HM
Lu
Yi-zeng
YZ
Liang
Pin
P
Qian
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D002351:Carrageenan; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D052859:Houttuynia / Q000737:chemistry; D007267:Injections; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal / Q000737:chemistry; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D011786:Quality Control; D051381:Rats; D017208:Rats, Wistar; D014992:Xylenes
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C442781:Houttuynia cordata extract; D014992:Xylenes; D002351:Carrageenan