Central nervous system and other effects.
Amylin enhanced the uptake of certain amino acids, crossed the blood-brain barrier, and increased body temperature. The physiological significance of these responses is currently unclear. An effect of peripherally injected amylin to enhance weakly trained memory fitted with similar effects of other gastrointestinal peptide hormones. Centrally administered amylin reduced locomotor and exploratory behavior. Amylin administered alone was analgesic when administered peripherally, via a non-opiate pathway. When administered in combination with opiates, there was an opiate-sparing synergy.
Young
Andrew
A
Amylin Pharmaceuticals, Inc., San Diego, California, USA.
D000682:Amyloid / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D058228:Islet Amyloid Polypeptide; D009043:Motor Activity / Q000187:drug effects
D000682:Amyloid; D058228:Islet Amyloid Polypeptide