[Correlation of tissue respiration and some mitochondria stereometric characteristics of the lung tissue in different modifications of hypoxic hypoxia].
In experiments on the adult white laboratory rats the correlation of tissue respiration and some morpho- and stereometric characteristics of mitochondria in lung tissue under breathing by air and gas mixture with 7% O2 in N2 was investigated. The following agents were used as modulators: indomethacin, a blockator of cyclooxygenase way of arachidonic acid metabolism; quercetin and linoleil of hydroxamic acid, blockators of lipooxygenase way ofarachidonic acid metabolism; taurine, an antihypoxant and energy source under hypoxic conditions; lipin-antihypoxant with significant membrane protective effect. It was shown, that the respiration intensity of tissue homogenate, not only of its mitochondrial fraction, closely connected with structural organization of mitochondria. It was demonstrated that changes of O2 concentration in gas mixture lead to the alteration of interrelation between O2 consumption and stereometric characteristics of mitochondria: in normoxia the intimate correlation was established with number of mitochondria and its total surface; in hypoxia such correlation was established with mitochondria diameter and number of structurally damage organelles. Pharmacological modulation factors play in this process not so significant role.
K V
KV
Rozova
A I
AI
Nazarenko
T I
TI
Tavolzhanova
T V
TV
Trepats'ka
M O
MO
Cherkesova
D000818:Animals; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology; D008168:Lung / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D010101:Oxygen Consumption; D051381:Rats