Urinary dysfunction and autonomic control in amyloid neuropathy.
Uro-neurological assessment was performed in four patients with small-fiber neuropathy due to amyloidosis (2 transthyretin-type/2 immunoglobulin light-chain-type). Voiding difficulties were due to detrusor weakness and impaired bladder sensation. In two patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity. The underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves.
Ito
Takashi
T
Neurology Dept., Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan.
Sakakibara
Ryuji
R
Yamamoto
Tatsuya
T
Uchiyama
Tomoyuki
T
Liu
Zhi
Z
Asahina
Masato
M
Higashi
Morihiro
M
Arai
Kimihito
K
Ito
Shoichi
S
Awa
Yusuke
Y
Yamamoto
Kaori
K
Kinou
Mika
M
Yamanishi
Tomonori
T
Hattori
Takamichi
T
D000368:Aged; D000369:Aged, 80 and over; D017772:Amyloid Neuropathies / Q000503:physiopathology*; D000686:Amyloidosis / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002799:Cholinergic Fibers / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000503:physiopathology; D009475:Neurons, Afferent / Q000502:physiology; D011228:Prealbumin / Q000502:physiology; D012189:Retrospective Studies; D001743:Urinary Bladder / Q000294:innervation; D014549:Urinary Incontinence / Q000503:physiopathology; D016055:Urinary Retention / Q000503:physiopathology; D014551:Urinary Tract / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology*
D011228:Prealbumin