Inactivation of herpes simplex virus clinical isolates by using a combination microbicide.
A combination microbicide using the lipid-ether 1-0-octyl-sn-glycerol (OG) (3 mM) and peptide LSA5 (9 microM) synergistically inactivated six clinical isolates of herpes simplex virus type 2 (HSV-2) by 30- to 100-fold and five of six HSV-1 isolates by 10-fold more than the sum of OG and LSA5 used individually within 30 min. OG plus LSA5 inactivated all HSV clinical isolates by > or = 1,000-fold in 10 to 40 min.
Institute for Basic Research, 1050 Forest Hill Road, Staten Island, New York 10314, USA. chisi@cunyvm.cuny.edu
Charles E
CE
Isaacs
Lisa
L
Rohan
Weimin
W
Xu
Jun Hua
JH
Jia
Timothy
T
Mietzner
Sharon
S
Hillier
D000998:Antiviral Agents / Q000494:pharmacology*; D004338:Drug Combinations; D005995:Glyceryl Ethers / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000302:isolation & purification; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007700:Kinetics; D010455:Peptides / Q000494:pharmacology*
D000998:Antiviral Agents; D004338:Drug Combinations; D005995:Glyceryl Ethers; D010455:Peptides