Understanding apoptosis in terms of QSAR.
Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.
Verma
Rajeshwar P
RP
Department of Chemistry, Pomona College, Claremont, CA 91711, USA. rverma@pomona.edu
D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000201:enzymology / Q000473:pathology; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D021281:Quantitative Structure-Activity Relationship
D020169:Caspases