Outcome after preterm delivery of infants antenatally diagnosed with congenital heart disease.
OBJECTIVE
To determine outcome of delivery before 36 weeks gestation in babies diagnosed antenatally with serious congenital heart disease (CHD).


METHODS
A retrospective database review at 2 tertiary care fetal cardiology centers. Details of neonatal course and outcome were obtained for those antenatally diagnosed with serious CHD who were live born before 36 weeks gestation.


RESULTS
Between January 1998 and December 2002, 9918 women were referred for fetal echocardiography. Serious CHD was diagnosed in 1191 fetuses (12%), of which 46 (4%) delivered prematurely. Median gestation was 33 (range 24-35) weeks, and median birth weight 1.56 (0.50-3.59) kg. Extracardiac/karyotypic anomalies occurred in 23 (50%). Twenty-six babies (57%) underwent neonatal surgery: 16 a cardiac procedure, 5 a general surgical procedure, and 5 both. Eight died during or after operation (31%). Two babies underwent interventional heart catheterization; both died. The overall mortality rate was 72%. Extracardiac/karyotypic anomalies increased the relative risk of death by a factor of 1.36. Mean hospital stay for those surviving to initial discharge was 46 (2-137) days.


CONCLUSIONS
There is a very high morbidity and mortality rate in this group, particularly for those with extracardiac/karyotypic anomalies. This should be reflected in decisions over elective preterm delivery and when counseling parents.
Guy's and St Thomas' Hospital and Great Ormond Street Hospital for Children, London, United Kingdom. rachel.andrews@gstt.nhs.uk
R E
RE
Andrews
J M
JM
Simpson
G K
GK
Sharland
I D
ID
Sullivan
R W M
RW
Yates
D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000401:mortality; D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D002869:Chromosome Aberrations; D004452:Echocardiography; D005260:Female; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D011247:Pregnancy; D047928:Premature Birth; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D006113:United Kingdom / Q000453:epidemiology