[Modern pharmacotherapy of benign prostatic hyperplasia].
Benign prostatic hyperplasia is the most common medical problem affecting elderly men throughout the world. With increasing awareness of health issues amongst males, the morbidity caused by this disease is not longer being accepted as just part of growing old. Until about 10 years ago, surgery was the only effective treatment for symptomatic benign prostatic hyperplasia. Now, many men suffering from this disorder may be effectively treated with a medical therapy. This article provides an overview of the efficacy and safety of 5alpha-reductase inhibitors, alpha1-adrenoceptor antagonists and herbal remedies, putting special emphasis on the current place of these agents in the modem therapy of benign prostatic hyperplasia. Wherever possible, our opinion is based on the detailed analysis of the results of available clinical trials.
Krysiak
Robert
R
Katedra Farmakologii Zakładu Farmakologii Klinicznej Slaskiej Akademii Medycznej w Katowicach. r.krysiak@pharmanet.com.pl
Okopień
Bogusław
B
Szkróbka
Witold
W
Herman
Zbigniew Stanisław
ZS
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D042944:Cholestenone 5 alpha-Reductase / Q000037:antagonists & inhibitors*; D005233:Fatty Alcohols / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000628:therapy*; D018340:Receptors, Adrenergic, alpha-1; D012434:Secale; D028024:Serenoa
C547713:ADRA1A protein, human; D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D005233:Fatty Alcohols; D010936:Plant Extracts; D018340:Receptors, Adrenergic, alpha-1; C009375:Tadenan; C010070:cernilton; D042944:Cholestenone 5 alpha-Reductase; C040972:saw palmetto extract