[Protective effect of curcumin on myocardial ischemia reperfusion injury in rats].
OBJECTIVE
To study the protective effect of curcumin on myocardial reperfusion injury in rats.


METHODS
Myocardial ischemia reperfusion injury model was established by occluding the left anterior descending branch of coronary arter for 60 min and removing the ligation later to reperfuse for 60 min in vivo. Different dose of curcumin were administered by intravenous injection 5 min before the onset of ischemia. The changes of myocardial infarct sizes (MIS), the serum creatine phosphokinase (CK) and lactate dehydrogenase (LDH), the myocardial malondialdehyed (MDA) and free fatty acid (FFA) content, the myocardial super oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity were measured.


RESULTS
Curcumin (20, 40 mg/kg) reduced the myocardial infarct sizes, the serum CK and LDH activity. The myocardial MDA and FFA content all declined. SOD and GSH-Px activity were increased markedly.


CONCLUSIONS
Curcumin exerts protective effects on myocardial ischemia reperfusion injury, which may be due to its function of inhibition of lipid peroxidation, augmentation of endogenous antioxidants and improving myocardial metabolism.
Dept of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071.
Hong
H
Cheng
Weiguan
W
Liu
Xiaomei
X
Ai
D000818:Animals; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010789:Phototherapy; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D003474:Curcumin