Antisaccade deficit after inactivation of the principal sulcus in monkeys.
The antisaccade (AS) task, which requires the ability to suppress unwanted reflexive glances, has proven to be a powerful tool for the analysis of executive control. Performing this task activates a large frontoparietal network, but which area is specifically responsible for reflexive saccade (RS) inhibition has not yet been demonstrated. We reversibly inactivated portions of the principal sulcus in 2 monkeys trained to perform AS and RS tasks. Here we show that inactivation of a circumscribed area in the ventral bank of the principal sulcus induced a strong impairment of RS inhibition without affecting RS triggering. Our results are compatible with a partitioning of the principal sulcus into functional subregions, in which a well-delineated area is critically involved in RS suppression.
Institut National de la Santé et de la Recherche Médicale U679, Universite Pierre and Marie Curie, France.
Carine
C
Condy
Nicolas
N
Wattiez
Sophie
S
Rivaud-Péchoux
Léon
L
Tremblay
Bertrand
B
Gaymard
D000818:Animals; D002522:Chlorocebus aethiops; D003627:Data Interpretation, Statistical; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology; D009415:Nerve Net / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D012438:Saccades / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology
D018755:GABA Agonists; D009118:Muscimol