Zebrafish z-otu, a novel Otu and Tudor domain-containing gene, is expressed in early stages of oogenesis and embryogenesis.
Several studies have suggested that Otu domain had de-ubiquitinating activity and Tudor domain was important for the formation of germ cells. Here, we reported a novel zebrafish ovary-specific gene containing Otu and Tudor domain, z-otu, which was expressed at stages I-III oocytes and embryonic stages from zygotes to early blastula during embryonic cells maintained their totipotency. Therefore, z-otu might link the ubiquitin signaling pathway to early oogenesis and maintaining the totipotency of embryonic cell.
Laboratory of Molecular Genetics and Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Saijun
S
Mo
Ping
P
Song
Daoyuan
D
Lv
Yungui
Y
Chen
Wei
W
Zhou
Wuming
W
Gong
Zuoyan
Z
Zhu
D000595:Amino Acid Sequence; D000818:Animals; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000166:cytology; D047108:Embryonic Development / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D009866:Oogenesis / Q000235:genetics*; D010053:Ovary / Q000166:cytology; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics*; D029961:Zebrafish Proteins / Q000737:chemistry / Q000235:genetics*
D012333:RNA, Messenger; D029961:Zebrafish Proteins; D003546:Cysteine Endopeptidases; C509509:alg13 protein, zebrafish