Comparison of the hydrolytic degradation and deformation properties of a PLLA-lauric acid based family of biomaterials.
Addition of lauric acid to PLLA results in a significantly increased rate of hydrolytic degradation, with the time-to-loss of tensile strength directly related to the concentration of lauric acid. In this study, the hydrolytic degradation profiles of four materials were studied: amorphous PLLA, amorphous PLLA containing 1.8 wt % lauric acid, amorphous PLLA containing 4.5 wt % lauric acid, and pre-crystallized PLLA containing 1.8 wt % lauric acid. Hydrolytic degradation was monitored through mass profiles, molecular weight profiles, crystallinity and the development of mechanical properties and deformation mechanisms (through simultaneous small-angle X-ray scattering and tensile testing), and a "phase diagram" of properties suggested. The key factor in determining the development of properties was found to be the time at which crystallization occurred in relation to the loss of molecular weight, with the two factors most affecting this being the lauric acid content and the pre-degradation annealing treatment.
Department of Material Science and Metallurgy, University of Cambridge, CB2 3QZ, United Kingdom.
Annette C
AC
Renouf-Glauser
John
J
Rose
David F
DF
Farrar
Ruth Elizabeth
RE
Cameron
D001672:Biocompatible Materials / Q000737:chemistry*; D003460:Crystallization; D006868:Hydrolysis; D007850:Lauric Acids / Q000737:chemistry*; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D013997:Time Factors
D001672:Biocompatible Materials; D007850:Lauric Acids; D011091:Polyesters; C030358:lauric acid; C033616:poly(lactide)