Drug-induced metabolic syndrome.
The metabolic syndrome is a cluster of risk factors associated with an increased risk for cardiovascular disease and type 2 diabetes. Based on data from 1988 to 1994, it is estimated that 24% of adults in the United States meet the criteria for diagnosis of the metabolic syndrome. The use of certain medications may increase the risk of the metabolic syndrome by either promoting weight gain or altering lipid or glucose metabolism. Health providers should recognize and understand the risk associated with certain medications and appropriately monitor for changes related to the metabolic syndrome. Careful attention to drug choices should be paid in patients who are overweight or have other risk factors for diabetes or cardiovascular disease.
Department of Internal Medicine, Division of General Internal Medicine/Hypertension, University of Mississippi Medical Center School of Medicine, Jackson, MS 39216, USA. mwofford@medicine.umsmed.edu
Marion R
MR
Wofford
Deborah S
DS
King
T Kristopher
TK
Harrell
D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000209:etiology; D003276:Contraceptives, Oral / Q000009:adverse effects; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D044882:Glucose Metabolism Disorders / Q000139:chemically induced; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D006949:Hyperlipidemias / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000009:adverse effects; D050356:Lipid Metabolism / Q000187:drug effects; D024821:Metabolic Syndrome / Q000139:chemically induced* / Q000150:complications; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D015430:Weight Gain / Q000187:drug effects
D000959:Antihypertensive Agents; D014150:Antipsychotic Agents; D003276:Contraceptives, Oral; D007166:Immunosuppressive Agents