Novel parvovirus and related variant in human plasma.
We report a novel parvovirus (PARV4) and related variants in pooled human plasma used in the manufacture of plasma-derived medical products. Viral DNA was detected by using highly selective polymerase chain reaction assays; 5% of pools tested positive, and amounts of DNA ranged from <500 copies/mL to >106 copies/mL plasma.
National Institute for Biological Standards and Control, Hertfordshire, United Kingdom.
Jacqueline F
JF
Fryer
Amit
A
Kapoor
Philip D
PD
Minor
Eric
E
Delwart
Sally A
SA
Baylis
D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D006801:Humans; D010322:Parvoviridae Infections / Q000097:blood* / Q000821:virology*; D017992:Parvovirus / Q000235:genetics* / Q000302:isolation & purification*; D010802:Phylogeny; D010949:Plasma / Q000821:virology*
D004279:DNA, Viral