Hair cell regeneration: an exciting phenomenon...but will restoring hearing and balance be possible?
Sensory hair cells of the inner ear are susceptible to damage from a variety of sources including aging, genetic defects, and environmental stresses such as loud noises or chemotherapeutic drugs. Unfortunately, the consequence of this damage in humans is often permanent hearing/balance problems. The discovery that hair cells can regenerate in birds and other nonmammalian vertebrates has fueled a wide range of studies that are designed to find ways of restoring hearing and balance after such damage. In this review, we will discuss some of the key recent findings in sensory hair cell regeneration and what they mean for audiologists and other hearing healthcare practitioners.
Matsui
Jonathan I
JI
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. jmatsui@fas.harvard.edu
Ryals
Brenda M
BM
D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology; D007758:Ear, Inner / Q000276:immunology / Q000502:physiology; D015870:Gene Expression; D023281:Genomics; D018069:Hair Cells, Vestibular / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D006319:Hearing Loss, Sensorineural / Q000235:genetics / Q000276:immunology / Q000503:physiopathology / Q000534:rehabilitation*; D006801:Humans; D012038:Regeneration / Q000276:immunology / Q000502:physiology*; D033581:Stem Cell Transplantation