A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris.
A balanced translocation was recently identified in a German psoriasis patient. One of the breakpoints was mapped immediately upstream of the microsomal glutathione S-transferase 2 (MGST2) gene, suggesting it as a candidate gene. Here, we report the identification of a novel non-synonymous mutation in MGST2 by a comprehensive sequence analysis of MGST2's coding region in Chinese psoriasis samples. We demonstrate that this mutation co-segregated with the disease phenotype within a Chinese family affected with psoriasis vulgaris and is predicted to have an impact on the normal function of MGST2 protein. However, the mutation was absent in 551 additional cases and 384 healthy Chinese controls. While requiring independent confirmation, our results suggest that this rare mutation could play a causal role in a small subset of psoriasis individuals.
Yan
Kai-Lin
KL
Institute of Dermatology & Department of Dermatology at No. 1 Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China.
Zhang
Xue-Jun
XJ
Wang
Zhi-Min
ZM
Yang
Sen
S
Zhang
Guo-Long
GL
Wang
Jian
J
Xiao
Feng-Li
FL
Gao
Min
M
Cui
Yong
Y
Chen
Jian-Jun
JJ
Fan
Xing
X
Sun
Liang-Dan
LD
Xia
Qing
Q
Zhang
Kai-Yue
KY
Niu
Zhen-Min
ZM
Xu
Shi-Jie
SJ
Tzschach
Andreas
A
Ropers
Hilger
H
Huang
Wei
W
Liu
Jian-Jun
JJ
D000328:Adult; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D016366:Open Reading Frames; D010375:Pedigree; D011565:Psoriasis / Q000235:genetics*
D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase