[The relationship between changes of serum antisperm antibodies before and post vasovasostomy and pregnancy rate].
OBJECTIVE
To investigate the changes and variation of serum antisperm antibodies (AsAb) from the men who received vasovasostomy 2 years after one of three methods of male sterilization, and evaluate the relationship between serum AsAb and pregnancy rate.


METHODS
Sperm reappearance, serum AsAb and pregnancy rate were investigated in 88 subjects who underwent reversal operation 2 years after one of three methods of male sterilization at 3, 6, 12 and 24 months post vasovasostomy.


RESULTS
There was no significant difference in positive rate of AsAb among groups of vasovasostomized men post one of three methods of sterilization, and between groups before and post vasovasostomy and between groups with and without sperm reappearance, respectively. The positive rate, intensity (percentage of motile sperm coated with beads) and type of serum AsAb had no influences on pregnancy. No significant difference was observed in positive rate of AsAb between pregnant group and non-pregnant group. The pregnancy rate of the group in which sperm concentration was more than 20 x 10(6)/ml was apparently higher than that of the group in which sperm concentration was less than 20 x 10(6)/ml.


CONCLUSIONS
The serum AsAb and their positive rate can not be eliminated or decreased by vasovasostomy post male sterilization. The serum AsAb has no influence on pregnancy. There is a close relationship between sperm quality and pregnancy post vasovasostomy.
Department of Male Clinic Research, National Research Institute for Family Planning, Beijing 100081. luwh65@yahoo.com.cn
Wen-hong
WH
Lu
Xiao-wei
XW
Liang
Yi-qun
YQ
Gu
Hong
H
Li
Zhi-gang
ZG
Wu
Zhen-wen
ZW
Chen
D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D013094:Spermatozoa / Q000276:immunology*; D013243:Sterilization Reversal; D014669:Vasovasostomy
D001323:Autoantibodies