CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling.
Multiple members of the casein kinase I family of serine/threonine protein kinases are involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci-Slimb/beta-TrCP binding.
Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom. m.a.price@sheffield.ac.uk
Mary Ann
MA
Price
D000595:Amino Acid Sequence; D047389:Casein Kinase I / Q000235:genetics / Q000378:metabolism*; D004789:Enzyme Activation / Q000235:genetics; D053823:Hedgehog Proteins; D008954:Models, Biological; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D010766:Phosphorylation; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*
D053823:Hedgehog Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D047389:Casein Kinase I