Auditory event-related responses in children with semi-lobar holoprosencephaly.
The purpose of this study was to evaluate auditory sensory and discrimination responses in children with semi-lobar holoprosencephaly (HPE). Event-related potential (ERP) signals were recorded to tone pair stimuli at 62 electrode sites from the scalp using an oddball paradigm (a two-block design, inter-stimulus interval=70 or 300 ms; frequency of tone pair=100 vs. 100 Hz for the frequent and 100 vs. 300 Hz for the infrequent). Latencies and amplitudes of P150, N250, and mismatch negativity (MMN)-like components were compared between children with HPE and controls. Our results revealed less organized ERP waveforms to both stimuli in children with HPE, with diminished P150 and N250 components across brain area. Robust and delayed MMN-like responses were elicited from the children with HPE, with decreased MMN amplitudes in the central, parietal, occipital, and posterior temporal areas. Our results suggest that while brain sensory responses to auditory tones may be impaired in children with semi-lobar HPE, subcomponents of auditory discrimination processes remain functional.
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA. jinghongkui@uams.edu
Hongkui
H
Jing
Judy
J
Flax
Cynthia P
CP
Roesler
Naseem
N
Choudhury
April A
AA
Benasich
D000161:Acoustic Stimulation; D001303:Auditory Cortex / Q000002:abnormalities / Q000503:physiopathology; D001306:Auditory Pathways / Q000002:abnormalities / Q000503:physiopathology; D001308:Auditory Perceptual Disorders / Q000175:diagnosis / Q000503:physiopathology*; D001921:Brain / Q000002:abnormalities* / Q000503:physiopathology*; D002675:Child, Preschool; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D007805:Language Development Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009421:Nervous System Malformations / Q000175:diagnosis / Q000503:physiopathology*; D010897:Pitch Discrimination / Q000502:physiology