[Calcium concentration in the skin of male rats exposed to high doses of ochratoxin A (OTA)].
BACKGROUND
Ochratoxin A (OTA) is one of mycotoxines that most frequently creates occupational hazards. The aim of the study was to observe calcium concentration in the skin of test animals exposed to high doses of ochratoxin A (OTA).


METHODS
Tests were carried out in two groups of male rats exposed to high doses of OTA (1 mg/kg(-1)) for 30 days. One of these groups was additionally administered MgCl2 in a dose of 5 mg/kg(-1). The results were compared with the control group. The animals were decapitated and the obtained skins were degreased and mineralized. The element was marked by AAS method on AAS-3 apparatus.


RESULTS
After completing the experiment, a significant (p < 0.001) rise in calcium concentration was found in the skin of animals in both tested groups compared with the control one. The group given at the same time OTA and MgCl2 had a significantly lower (p < 0.001) calcium concentration in the skin than that exposed to OTA only.


CONCLUSIONS
Administration of high doses of OTA characteristically increases calcium concentration in animal skin. Simultaneous administration of OTA in high doses and magnesium chloride in low doses also significantly increases calcium concentration in animal skin.
Centrum Medycyny Pracy w Gnieźnie, Akademii Medycznej w Lublinie. pksplezia@op.pl
Włodzimierz
W
Bulikowski
Andrzej
A
Borzecki
Ryszard
R
Skorupski
Katarzyna
K
Trocka
Wiesław
W
Lingas
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002273:Carcinogens / Q000633:toxicity*; D005506:Food Contamination; D008297:Male; D009793:Ochratoxins / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000737:chemistry / Q000378:metabolism*
D002273:Carcinogens; D009793:Ochratoxins; C025589:ochratoxin A; D002118:Calcium