Adipose tissue and cytokines.
Adipose tissue is not simply a storage depot for excess energy intake, it is also able to produce and release several substances with local (autocrine) and systemic (endocrine) actions. An up-to-date review of our knowledge in this area is given here. Several of the compounds deriving from adipose tissue have been shown to play a role in obesity-related health complications. The production of cytokines, such as Tumor Necrosis Factor-alpha (TNF-alpha), IL-6, and leptin, is implicated in the development of several disorders. Insulin resistance is one of the most clinically significant.
Università degli Studi--Milano, Laboratorio di Analisi Chimico-cliniche, IRCCS Fondazione C. Mondino.
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Trotti
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Cestaro
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Cazzola
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Ferrari
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Rondanelli