Elimination mechanisms of therapeutic monoclonal antibodies.
Targeted therapies using monoclonal antibodies have achieved important therapeutic applications in the treatment of various human diseases. Understanding the factors that impact the pharmacokinetics of monoclonal antibodies is of high importance for effective therapy. Many factors related to the target antigen, antibody and patients can affect antibody elimination. Evaluation of these factors will facilitate the understanding of the processes involved in antibody elimination.
Tabrizi
Mohammad A
MA
Abgenix, Pharmacokinetics & Toxicology, 6701 Kaiser Drive, Fremont, CA 94556, USA.
Tseng
Chih-Ming L
CM
Roskos
Lorin K
LK
D000818:Animals; D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D000941:Antigens / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008657:Metabolic Clearance Rate
D000911:Antibodies, Monoclonal; D000941:Antigens; D007074:Immunoglobulin G