[Effects of continuous infusion of landiolol on the hemodynamic response to tracheal intubation].
BACKGROUND
The clinical effect of continuous infusion of landiolol with buprenorphine and lidocaine was evaluated for its effects an attenuating the cardiovascular responses to endotracheal intubation.


METHODS
Tracheal intubation was performed by the same anesthesiologist after induction of anesthesia with propofol, ketamine, midazolam, buprenorphine and lidocaine, followed by administration of vecuronium, and continuous infusion of saline (Group C; n = 20) or landiolol 0.02 (Group L 2; n = 25) or landiolol 0.04 mg x kg(-1) x min(-1) (Group L4; n = 22). Heart rate (HR), systolic (sBP) and diastolic blood pressure (dBP) were recorded just before induction of anesthesia, just after and 10 min after tracheal intubation.


RESULTS
Just after tracheal intubation, HR in the Groups C and L 2, but not in the group L 4, increased significantly from the baseline. Just after the tracheal intubation, sBP in the Group L 2 decreased from the baseline, and 10 min after intubation sBP in all groups decreased significantly from the baseline. Just after tracheal intubation, dBP in all groups was unchanged, and dBP in the Groups C and L 4 decreased from the baseline 10 min after the intubation.


CONCLUSIONS
Continuous infusion of landiolol 0.04 mg x kg(-1) x h(-1) with buprenorphine and lidocaine can completely attenuate the hemodynamic response to tracheal intubation.
Onaka
Masahiko
M
Department of Anesthesia, Shiroyama Hospital, Habikino 583-0852.
Yamamoto
Hiromitsu
H
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002047:Buprenorphine / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D008012:Lidocaine / Q000008:administration & dosage; D009025:Morpholines / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D009025:Morpholines; D002047:Buprenorphine; C077049:landiolol; D014508:Urea; D008012:Lidocaine