Beta1 adrenergic receptor polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo populations of Mexico.
The beta1 adrenergic receptor genotypes (Ser49Gly and Arg389Gly) were determined in 190 individuals from 3 Mexican populations. Mestizos and Teenek present the highest frequencies for the *Arg allele and the lowest frequencies for the *Gly allele (Arg389Gly) compared to European, Asian, and African populations. Mayos present the highest frequency for the *Gly allele. The knowledge of the distribution of these alleles could help define the significance of these polymorphisms as genetic susceptibility markers in Amerindian populations.
Department of Physiology and Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Tlalpan 14080, Mexico City, Mexico.
José Manuel
JM
Fragoso
José Manuel
JM
Rodríguez-Pérez
Nadia
N
Pérez-Vielma
Nancy
N
Martínez-Rodríguez
Gilberto
G
Vargas-Alarcón
D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D007802:Language; D008297:Male; D008800:Mexico; D011110:Polymorphism, Genetic