Substituted alpha-(phenylhydrazono)phenylacetonitrile derivatives. Part 2: Synthesis and biological activity of pro-pesticides.
Pro-pesticides of alpha-(2,6-dichloro-4-trifluoromethylphenylhydrazono)-4-nitrophenylacetonitrile have been prepared and tested against mite and insect pests. Variations in potency and spectrum were observed depending on the choice of cleavable pro-moiety. Cleavage of the pro-moiety was demonstrated in one case by measuring the rate of increase in the uncoupling activity using a mitochondrial preparation. Irradiation experiments have demonstrated a rapid isomerisation of the planar Z isomer to the E isomer, which is reversible.
Syngenta Crop Protection AG, CH-4002 Basel, Switzerland.
Thomas
T
Flury
Roger G
RG
Hall
Friedrich
F
Karrer
Heinz
H
Kienast
Katrin
K
Leuenberger
Alfons
A
Pascual
Alfred
A
Rindlisbacher
Stephan
S
Trah
Hans-Joerg
HJ
Widmer
D000097:Acetonitriles / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001042:Aphids / Q000528:radiation effects; D001517:Coleoptera / Q000528:radiation effects; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis*; D015394:Molecular Structure; D009036:Moths / Q000528:radiation effects; D011355:Prodrugs / Q000138:chemical synthesis / Q000494:pharmacology; D040102:Tetranychidae / Q000528:radiation effects; D014475:Uncoupling Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D000097:Acetonitriles; D006835:Hydrazones; D007306:Insecticides; D011355:Prodrugs; D014475:Uncoupling Agents