A novel guanylyl cyclase receptor, BdmGC-1, is highly expressed during the development of the oriental fruit fly Bactrocera dorsalis (Hendel).
A novel receptor guanylyl cyclase (GC) has been identified from the oriental fruit fly Bactrocera dorsalis (Hendel) and has been designated BdmGC-1. Protein domain analysis revealed that BdmGC-1 possesses a characteristic domain organization similar to all known receptor GCs but with a unique carboxyl-terminal extension. When overexpressed in 293T cells, BdmGC-1 manifests as a cell-surface glycoprotein with a marked cGMP-generating activity but is unresponsive to all ligands known to activate mammalian receptor GCs. BdmGC-1 mRNAs were highly expressed during development but had low or no expression in adult tissues. On the basis of its unique sequence and distinct developmental expression pattern, BdmGC-1 represents a novel receptor GC that may play a critical role during the development of B. dorsalis.
Chang
J-C
JC
Department of Entomology, National Chung Hsing University, Taichung, Taiwan, Republic of China.
Yang
R-B
RB
Chen
Y-H
YH
Lu
K-H
KH
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D018507:Gene Expression Regulation, Developmental; D006031:Glycosylation; D006801:Humans; D008018:Life Cycle Stages; D008562:Membrane Glycoproteins / Q000032:analysis; D008969:Molecular Sequence Data; D017830:Octoxynol; D012333:RNA, Messenger; D050705:Receptors, Guanylate Cyclase-Coupled / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA; D033621:Tephritidae / Q000235:genetics* / Q000254:growth & development
D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D017830:Octoxynol; D050705:Receptors, Guanylate Cyclase-Coupled