Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk.
OBJECTIVE
Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease.


METHODS
In a case control study, we genotyped 242 ischemic stroke, 231 myocardial infarction (MI), and 310 healthy control subjects, all Chinese.


RESULTS
R-containing genotypes (R+) were associated with vascular disease, OR = 1.5, P = 0.03. RR was increased in MI patients who were either smokers (OR = 3.1, P = 0.01), male, or younger than 60. R+ but not RR genotypes were increased in stroke patients, particularly large artery type (OR = 2.6 and P = 0.02 for R+, OR = 1.0 for RR) or among smokers. The relative dearth of RR in stroke might be due to earlier MI or death in at-risk people, such as smokers. R+ genotypes were increased with stroke in hypertensive (OR = 2.1, P = 0.02) but not normotensive (OR = 1.0) subjects.


CONCLUSIONS
PON1 192R+ genotypes were associated with stroke and MI, particularly in subsets of patients, in patterns suggesting a possible survivor effect.
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong. lwbaum@cuhk.edu.hk
Larry
L
Baum
Ho Keung
HK
Ng
Kam Sang
KS
Woo
Brian
B
Tomlinson
Timothy Hudson
TH
Rainer
Xiangyan
X
Chen
Wing Sze
WS
Cheung
Daniel Kam Yin
DK
Chan
G Neil
GN
Thomas
Cindy See Wai
CS
Tong
Ka Sing
KS
Wong
D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012044:Regression Analysis; D020521:Stroke / Q000201:enzymology*
D043303:Aryldialkylphosphatase