The odyssey of k-ras.
A mechanism that regulates K-Ras signaling specificity by altering its subcellular location is presented by Bivona et al. (2006). Phosphorylation of its membrane-anchoring domain by PKC drives K-Ras off of the plasma membrane and onto the outer mitochondrial membrane where it induces cell death.
Feig
Larry A
LA
Department of Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
D000818:Animals; D016923:Cell Death / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D011905:Genes, ras; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000648:ultrastructure; D011493:Protein Kinase C / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D051020:bcl-X Protein / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D051020:bcl-X Protein; D011493:Protein Kinase C