Central precocious puberty in a girl with Williams syndrome: the result of treatment with GnRH analogue.
Williams syndrome (WS) is a well-known microdeletion syndrome characterized by specific facial features, retardation in growth and development, typical personality and cardiac defects. Poor growth potential is further affected by central precocious puberty (CPP) which is frequent in these patients. A WS patient with CPP is presented, whose pubertal development and bone age progression were arrested by administration of GnRH analogues. The case is reported to discuss the role of GnRH analogues for management of CPP in patients with WS.
Utine
G Eda
GE
Division of Genetics, Department of Pediatrics, Hacettepe University, Sihhiye, 06100 Ankara, Turkey. geutine@hacettepe.edu.tr
Alikasifoglu
Ayfer
A
Alikasifoglu
Mehmet
M
Tuncbilek
Ergul
E
D002648:Child; D005260:Female; D005385:Fingers / Q000002:abnormalities*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D011629:Puberty, Precocious / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D018980:Williams Syndrome / Q000175:diagnosis / Q000188:drug therapy*
D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide