Synthesis characterization and biological study of diorganotin(IV) complexes of monomethyl phthalate.
The synthesis and characterization of new coordination compounds of some organotin(IV) chlorides with monomethyl phthalate is reported; the ligand molecules appear to be bound to the tin atom through carbonyl oxygen atoms. Their structures have been characterized by elemental analyses, molar conductance, and bonding in these complexes is discussed in terms of their IR, (1)H, (13)C, (119)Sn NMR and (119 m)Sn Mössbauer spectral studies. The spectroscopic results obtained are in full agreement with the proposed 2:1 stoichiometry. The complexes soluble in DMSO have been screened against a wide spectrum of bacteria and the results obtained are quite promising. The LD(50) values have also been determined in the albino rats. Some of the complexes also exhibit high anti-inflammatory activity.
Department of Chemistry, Gomal University, Dera Ismail Khan, Pakistan. sono_wai@yahoo.com <sono_wai@yahoo.com>
Wajid
W
Rehman
Musa Kaleem
MK
Baloch
Amin
A
Badshah
Saqib
S
Ali
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002712:Chlorides / Q000737:chemistry; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010795:Phthalic Acids / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D014001:Tin / Q000032:analysis
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D002712:Chlorides; D009947:Organotin Compounds; D010795:Phthalic Acids; C517284:monomethyl phthalate; D014001:Tin; D004121:Dimethyl Sulfoxide