Astrocyte dysfunction in neurological disorders: a molecular perspective.
Recent work on glial cell physiology has revealed that glial cells, and astrocytes in particular, are much more actively involved in brain information processing than previously thought. This finding has stimulated the view that the active brain should no longer be regarded solely as a network of neuronal contacts, but instead as a circuit of integrated, interactive neurons and glial cells. Consequently, glial cells could also have as yet unexpected roles in the diseased brain. An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders.
Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany.
Gerald
G
Seifert
Karl
K
Schilling
Christian
C
Steinhäuser
D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology / Q000502:physiology*; D004827:Epilepsy / Q000378:metabolism / Q000473:pathology; D006501:Hepatic Encephalopathy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D020521:Stroke / Q000378:metabolism / Q000473:pathology