Acute insulin secretion as a predictor of weight gain in healthy humans.
OBJECTIVE
We sought to determine the role of the acute insulin secretory response to glucose (AIRg) in predicting weight gain in normoglycemic persons with no family history of diabetes, who are at low risk for development of disease.


METHODS
One hundred five individuals (64 men and 41 women) who underwent measures of weight and AIRg and insulin sensitivity index (S(I)) by intravenous glucose tolerance test between 1963 and 1983 were surveyed again for weight between 1994 and 1999, with a mean follow-up of 26 +/- 4 years.


RESULTS
Mean change in weight was 8 +/- 10 kg. Annualized weight change was calculated as change in kilograms divided by change in year and averaged 0.27 +/- 0.04 kg/yr. Dividing the cohort by either median AIRg or median S(I) demonstrated no association of either AIRg or S(I) with total or annualized weight gain. Subgroup analysis by ideal body weight or gender did not alter the association. Furthermore, no association between AIRg and weight gain rate was seen within insulin-sensitive or -resistant subgroups, although younger age at entry was associated with greater rates of weight gain.


CONCLUSIONS
Our data suggest that neither AIRg nor S(I) plays a role in predicting weight gain in normoglycemic individuals with no family history of diabetes.
Clinical Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA.
Robert J
RJ
Silver
Sheena
S
Mehta
J Stuart
JS
Soeldner
Blaise C
BC
Martin
James H
JH
Warram
Allison B
AB
Goldfine
D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D011237:Predictive Value of Tests; D015430:Weight Gain / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose