Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells.
Small RNA viruses such as influenza viruses extensively manipulate host-cell functions to support their replication. At the same time the infected cell induces an array of defence mechanisms to fight the invader. These processes are mediated by a variety of intracellular signalling cascades. Here we will review the current knowledge of functional kinase signalling and apoptotic events in influenza virus infected cells and how these viruses have learned to misuse these cellular responses for efficient replication.
Ludwig
Stephan
S
Institute of Molecular Virology (IMV) Westfaelische-Wilhelms-University, Von-Esmarch Str. 56, D-48161 Muenster, Germany. ludwigs@uni-muenster.de
Pleschka
Stephan
S
Planz
Oliver
O
Wolff
Thorsten
T
D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D009975:Orthomyxoviridae / Q000472:pathogenicity*; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction; D014779:Virus Replication
D011493:Protein Kinase C