[Relationship between insulin like hormone 3 and testicular descent and development].
Testicular descent is an essential step in the course of reproductive system development. The mechanisms involved in the regulation of testis descent is not distinct. Gubernaculum has a very close relationship with testis descent. Maldescent of testis can cause abnormalities of genital system such as testicular underwent (cryptorchidism), dysplasia, tumor, infertility and low sexuality. Recently insulin like hormone 3 is a hotspot of concerning affecting gubernacular development and testicular descent. This article briefly reviews the advances in these aspects.
Department of Pediatric Surgery, the Second Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China. xiexiaojun11908@tom.com
Xiao-jun
XJ
Xie
Xue-Wu
XW
Jiang
D000818:Animals; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011506:Proteins / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D013737:Testis / Q000254:growth & development*
D007328:Insulin; C084797:Leydig insulin-like protein; D011506:Proteins; D043562:Receptors, G-Protein-Coupled