Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite.
This study examined whether the potent cannabinoid HU210 ameliorates axonal injury through its indirect action to stimulate the secretion of corticosterone. We observed that HU210 dramatically reduced peroxynitrite-induced axonal injury in rats receiving adrenalectomy and corticosterone replacement treatment. These results suggest that the ameliorating effects of cannabinoids on axonal injury associated with multiple sclerosis are achieved by its direct action, but not by its indirect action to elevate the serum corticosterone levels.
Department of Physical Medicine and Rehabilitation, University of Saskatchewan, 701 Queen Street, Saskatoon, SK, Canada S7K 0M7.
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Yang
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Hader
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Zhang
D000315:Adrenalectomy / Q000379:methods; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000473:pathology*; D001927:Brain Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002186:Cannabinoids / Q000737:chemistry / Q000627:therapeutic use*; D003337:Corpus Callosum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003345:Corticosterone / Q000008:administration & dosage; D004195:Disease Models, Animal; D013759:Dronabinol / Q000031:analogs & derivatives / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008981:Molsidomine / Q000031:analogs & derivatives / Q000627:therapeutic use; D009025:Morpholines / Q000627:therapeutic use; D030421:Peroxynitrous Acid / Q000633:toxicity*; D011720:Pyrazoles / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D016564:Amyloid beta-Protein Precursor; D002186:Cannabinoids; D004791:Enzyme Inhibitors; D009025:Morpholines; D011720:Pyrazoles; D030421:Peroxynitrous Acid; C002385:linsidomine; D013759:Dronabinol; D008981:Molsidomine; C062018:HU 211; C109925:AM 281; D003345:Corticosterone