TLR2 is necessary to inflammatory response in Coxiella burnetii infection.
The resolution of Q fever, a zoonosis caused by Coxiella burnetii, depends on efficient innate and adaptive immune responses. Such responses are influenced by Toll-like receptors (TLRs). TLR4 is involved only in part in immune responses against C. burnetii, suggesting a role for TLR2. We investigated C. burnetii infection in wild-type and TLR2(-/-) mice. C. burnetii organisms were similarly eliminated by wild-type and TLR2(-/-) mice. In contrast, the formation of granulomas, a marker for efficient cell-mediated immunity, was markedly impaired. These results show that TLR2 is required for inflammatory and immune response to C. burnetii, but is dispensable for bacterial clearance.
Unité des Rickerrsies, CNRS UMR 6020, Université de Méditerranée, 13005 Marseille, France.
Soraya
S
Meghari
Amélie
A
Honstettre
Hubert
H
Lepidi
Bernardt
B
Ryffel
Didier
D
Raoult
Jean-Louis
JL
Mege
D000818:Animals; D016997:Coxiella burnetii / Q000276:immunology*; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000382:microbiology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology*; D008099:Liver / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011778:Q Fever / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D013154:Spleen / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D018836:Inflammation Mediators; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2