Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities.
Rubriflordilactones A (1) and B (2), two novel highly unsaturated rearranged bisnortriterpenoids possessing a biosynthetically modified aromatic D-ring, were isolated from the leaves and stems of Schisandra rubriflora. Their structures were established on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Compound 1 showed weak anti-HIV-1 activity, and compound 2 exhibited an EC50 value of 9.75 microg/mL (SI=12.39) against HIV-1 replication with low cytotoxicity.
Xiao
Wei-Lie
WL
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
Yang
Liu-Meng
LM
Gong
Ning-Bo
NB
Wu
Li
L
Wang
Rui-Rui
RR
Pu
Jian-Xin
JX
Li
Xiao-Li
XL
Huang
Sheng-Xiong
SX
Zheng
Yong-Tang
YT
Li
Rong-Tao
RT
Lu
Yang
Y
Zheng
Qi-Tai
QT
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C514794:rubriflordilactone A; C514795:rubriflordilactone B