Polyenylpyrroles and polyenylfurans from an Australian Isolate of the soil ascomycete Gymnoascus reessii.
[structure: see text] An Australian isolate of the soil ascomycete Gymnoascus reessii yielded a series of cytotoxic metabolites, including the known polyenylpyrroles rumbrin (1) and auxarconjugatin A (2), and the new rumbrin stereoisomer 12E-isorumbrin (3), as well as an unprecedented class of polyenylfurans exemplified by gymnoconjugatins A (4) and B (5). Structures were assigned with detailed spectroscopic analysis.
Clark
Benjamin R
BR
Institute for Molecular Biosciences, University of Queensland, QLD 4072, Australia.
Capon
Robert J
RJ
Lacey
Ernest
E
Tennant
Shaun
S
Gill
Jennifer H
JH
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001315:Australia; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D012988:Soil Microbiology
D000970:Antineoplastic Agents; D005663:Furans; D011753:Pyrones; D011758:Pyrroles; C514631:auxarconjugatin A; C514632:gymnoconjugatin A; C514633:gymnoconjugatin B; C082417:rumbrin