The incidence and risk factors for developing dry eye after myopic LASIK.
OBJECTIVE
To determine the incidence of dry eye and its risk factors after myopic laser-assisted in situ keratomileusis (LASIK).


METHODS
Single-center, prospective randomized clinical trial of 35 adult patients, aged 24 to 54 years, with myopia undergoing LASIK.


METHODS
setting and study population: Participants were randomized to undergo LASIK with a superior or a nasal hinge flap. They were evaluated at 1 week and 1, 3, and 6 months after surgery. intervention: Bilateral LASIK with either a superior-hinge Hansatome microkeratome (n = 17) or a nasal-hinge Amadeus microkeratome (n = 18). main outcome measures: The criterion for dry eye was a total corneal fluorescein staining score > or =3. Visual acuity, ocular surface parameters, and corneal sensitivity were also analyzed. Cox proportional-hazard regression was used to assess rate ratios (RRs) with 95% confidence intervals.


RESULTS
The incidence of dry eye in the nasal- and superior-hinge group was eight (47.06%) of 17 and nine (52.94%) of 17 at 1 week, seven (38.89%) of 18 and seven (41.18%) of 17 at 1 month, four (25%) of 16 and three (17.65%) of 17 at 3 months, and two (12.50%) of 16 and six (35.29%) of 17 at 6 months, respectively. Dry eye was associated with level of preoperative myopia (RR 0.88/each diopter, P = .04), laser-calculated ablation depth (RR 1.01/microm, P = 0.01), and combined ablation depth and flap thickness (RR 1.01/microm, P = 0.01).


CONCLUSIONS
Dry eye occurs commonly after LASIK surgery in patients with no history of dry eye. The risk of developing dry eye is correlated with the degree of preoperative myopia and the depth of laser treatment.
Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin Street, NC 205, Houston, TX 77030, USA.
Cintia S
CS
De Paiva
Zhuo
Z
Chen
Douglas D
DD
Koch
M Bowes
MB
Hamill
Francis K
FK
Manuel
Sohela S
SS
Hassan
Kirk R
KR
Wilhelmus
Stephen C
SC
Pflugfelder
D000328:Adult; D003315:Cornea / Q000601:surgery*; D015352:Dry Eye Syndromes / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D015590:Fluorophotometry; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D020731:Keratomileusis, Laser In Situ; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors; D013524:Surgical Flaps / Q000145:classification; D013997:Time Factors