Antiplasmodial flavonoids from Erythrina sacleuxii.
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4'-methoxy-3'-prenylisoflavone (trivial name 5-deoxy-3'-prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sacleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence.
Andayi
Andrew W
AW
Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Yenesew
Abiy
A
Derese
Solomon
S
Midiwo
Jacob O
JO
Gitu
Peter M
PM
Jondiko
Ogoche J
OJ
Akala
Hosea
H
Liyala
Pamela
P
Wangui
Julia
J
Waters
Norman C
NC
Heydenreich
Matthias
M
Peter
Martin G
MG
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D004895:Erythrina / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*
C509546:7-hydroxy-4'-methoxy-3'-prenylisoflavone; D000962:Antimalarials; D005419:Flavonoids; D007529:Isoflavones; D010936:Plant Extracts; D002738:Chloroquine