Long-lasting mechanical sensitization following third molar surgery.
OBJECTIVE
To investigate the degree and duration of neuronal hyperexcitability due to local inflammatory trauma after surgical removal of an impacted mandibular third molar.


METHODS
A total of 32 healthy men (16 patients, 16 control subjects) underwent quantitative sensory tests (QST) at baseline (preoperatively) and 2, 7, and 30 days following surgical removal of a mandibular third molar. Thermal and mechanical QST was applied to the extraoral and intraoral regions as well as to the dominant forearm.


RESULTS
Detection thresholds for thermal and mechanical stimuli did not change over time in patients and control subjects, but pain thresholds (thermal, pressure, electrical) in the control group increased significantly. Patients showed significantly decreased pain pressure thresholds and pressure pain tolerance (P < .05 for both) on the operated side and absence of adaptation to the tests for up to 30 days postoperatively.


CONCLUSIONS
These results indicate that even a minor surgical procedure in the orofacial region may be sufficient to evoke hyperexcitability in an area adjacent to the surgical wound for up to 30 days. The decreased adaptive capacity in the patient group also suggests the involvement of central pain-regulatory mechanisms in response to the surgical trauma.
Juhl
Gitte Irene
GI
Department of Neurology, Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark. gij@dadlnet.dk
Svensson
Peter
P
Norholt
Sven Erik
SE
Jensen
Troels Staehelin
TS
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D005157:Facial Pain / Q000209:etiology; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold; D020886:Somatosensory Disorders / Q000209:etiology*; D018709:Statistics, Nonparametric; D014081:Tooth Extraction / Q000009:adverse effects*