Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis.
OBJECTIVE
To investigate the expression of co-stimulatory molecule B7-H3 in gastric carcinoma and adenoma tissue as well as normal gastric tissue and to explore the relationship between B7-H3 expression and pathological features and prognosis of gastric carcinoma.


METHODS
B7-H3 expression was detected in 102 samples of human gastric carcinoma and 10 samples of gastric adenoma and 10 samples of normal gastric tissue by immunohistochemical assay. Correlation between the expression of B7-H3 and the patients' age, sex, gastric carcinoma locus, tumor size, tissue type, tumor infiltration depth, differentiation degree, lymph node metastasis, and survival time was analyzed.


RESULTS
B7-H3 was expressed in all gastric adenoma samples and in 58.8% samples of gastric carcinoma. B7-H3 expression in gastric carcinoma samples was not related with the patients' age, sex, lymph node metastasis, and tumor size (P>0.05), but with the survival time, infiltration depth of tumor and tissue type.


CONCLUSIONS
Detection of B7-H3 expression in gastric carcinoma tissue is beneficial to the judgment of the prognosis of gastric carcinoma patients and the choice of treatment.
The Third Affiliated Hospital of Suzhou University, Changzhou 213003, Jiangsu Province, China. newwcp@163.com
Chang-Ping
CP
Wu
Jing-Ting
JT
Jiang
Min
M
Tan
Yi-Bei
YB
Zhu
Mei
M
Ji
Kuan-Feng
KF
Xu
Jie-Min
JM
Zhao
Guang-Bo
GB
Zhang
Xue-Guang
XG
Zhang
D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D015703:Antigens, CD; D060887:B7 Antigens; D018122:B7-1 Antigen / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D011971:Receptors, Immunologic; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D015996:Survival Rate
D015703:Antigens, CD; D060887:B7 Antigens; D018122:B7-1 Antigen; C423237:CD276 protein, human; D011971:Receptors, Immunologic