Association between an IGF-I gene polymorphism and body fatness: differences between generations.
OBJECTIVE
A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations.


METHODS
Observational study with repeated measurements.


METHODS
The study group consisted of two comparable young Dutch cohorts with a generational difference of around 20 years. The older cohort consisted of 359 subjects born between 1961 and 1965. Measurements were performed from 13 until 36 years of age. The younger cohort consisted of 258 subjects born between 1981 and 1989. Measurements were performed from 8 until 14 years of age. Height, body mass index (BMI), fat mass, fat-free mass, waist and hip circumference were compared between wild-type carriers and variant type carriers of the IGF-I polymorphism.


RESULTS
In the younger cohort, body weight, BMI, fat mass and waist circumference were significantly higher in female variant carriers of the IGF-I polymorphism. A similar trend was observed in male variant carriers. In contrast, these differences were not observed in the older cohort. Irrespective of genotype, the younger cohort showed a significantly higher total fat mass, body weight and BMI compared with the older cohort.


CONCLUSIONS
Because the differences between both genotypes were small, it seems likely that the genetic variability due to this IGF-I polymorphism impacts only slightly on body composition. Importantly, our study suggested that associations between this IGF-I promoter polymorphism and body composition possibly reflect a gene-environmental interaction of this polymorphism and that an environment that promotes obesity leads to a slightly more pronounced fat accumulation in variant carriers of this IGF-I polymorphism.
Voorhoeve
Paul G
PG
Department of Pediatric Endocrinology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
van Rossum
Elisabeth F C
EF
Te Velde
Saskia J
SJ
Koper
Jan W
JW
Kemper
Han C G
HC
Lamberts
Steven W J
SW
de Waal
Henriette A Delemarre-van
HA
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000886:Anthropometry; D001823:Body Composition / Q000235:genetics / Q000502:physiology*; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011110:Polymorphism, Genetic; D049629:Waist-Hip Ratio
D007334:Insulin-Like Growth Factor I; D004247:DNA