Early optical coherence tomography changes after photodynamic therapy in patients with age-related macular degeneration.
OBJECTIVE
To evaluate early changes after photodynamic therapy (PDT) in patients with age-related macular degeneration (AMD) by optical coherence tomography (OCT).


METHODS
Prospective interventional case series.


METHODS
PDT was performed on 20 eyes of 20 patients who presented with subfoveal choroidal neovascularization (CNV) attributable to AMD. OCT was used to evaluate changes at 2, 12, and 24 hours and at 3, 7, 15, and 30 days after therapy.


RESULTS
In the first 24 hours, OCT showed an increase in the subretinal fluid (SF) in all eyes and an increase in intraretinal fluid (IF) in 13 eyes. On the 15th day and the 30th day after therapy, reduction of SF and IF was observed in almost all eyes.


CONCLUSIONS
Serial OCT evaluation of patients with subfoveal CNV attributable to AMD suggests that the initial response after PDT is an increase in SF and IF.
Istanbul Retina Institute Inc, Hakki Yeten Caddesi No. 8, K.7, 34349 Sisli-Istanbul, Turkey.
Hakan
H
Ozdemir
Serra Arf
SA
Karacorlu
Murat
M
Karacorlu
D000368:Aged; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy; D045604:Extracellular Fluid; D005122:Exudates and Transudates; D005451:Fluorescein Angiography; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008268:Macular Degeneration / Q000175:diagnosis* / Q000188:drug therapy*; D008875:Middle Aged; D010778:Photochemotherapy; D011446:Prospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity