Gradual elimination of retroviruses in YBR/Ei mice.
Mouse mammary tumor virus (MMTV), a well-characterized retrovirus that causes mammary tumors in susceptible mice, is commonly used to investigate virus-host interactions. We have shown that YBR/Ei mice demonstrate a novel, dominant mechanism of resistance to MMTV infection and MMTV-induced mammary tumors. MMTV can both establish infection in YBR/Ei mice and be transmitted by YBR/Ei mice as an infectious virus. However, virus production is severely attenuated, resulting in gradual clearance of infection in successive generations. Our transfer experiments showed that T cells generated in MMTV-infected resistant mice were required to restrict MMTV replication in susceptible mice. These results emphasize the importance of inducing T-cell responses for effective protection against retroviral infections.
The Jackson Laboratory, Bar Harbor Maine 04609, USA.
Cameron C
CC
MacDearmid
Laure K
LK
Case
Christa L
CL
Starling
Tatyana V
TV
Golovkina
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D020077:Endogenous Retroviruses / Q000502:physiology; D005260:Female; D007113:Immunity, Innate; D008221:Lymphoid Tissue / Q000821:virology; D008321:Mammary Glands, Animal / Q000821:virology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology* / Q000821:virology*; D008324:Mammary Tumor Virus, Mouse / Q000502:physiology*; D051379:Mice; D011533:Proviruses / Q000235:genetics; D012192:Retroviridae Infections / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology*; D016662:Virus Integration / Q000235:genetics
D000914:Antibodies, Viral; D004279:DNA, Viral