Intramolecular cyclopropanation of unsaturated terminal aziridines.
Regio- and stereoselective deprotonation of bishomoallylic terminal N-Bus (Bus=tert-butylsulfonyl)-protected aziridines generate aziridinyl anions that undergo diastereoselective intramolecular cyclopropanation giving trans-2-aminobicyclo[3.1.0]hexanes in good to excellent yields.
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. david.hodgson@chem.ox.ac.uk
David M
DM
Hodgson
Philip G
PG
Humphreys
John G
JG
Ward