Electrophysiological markers of visuocortical development.
The development of noninvasive techniques for the assessment of functional brain maturation is critical. The present study analyzed 63 babies' and children's (27 days to 5.5 years) cerebral responses to a pattern-reversal visual stimulation using high-density (128 electrodes) electrophysiological recordings. Developmental data were further compared with those of young adults (n = 16). Tremendous changes in pattern visual evoked potentials (pVEPs) morphology were observed between 7 and 24 months characterized by the emergence of negative components labeled "N70" and "N145" and the reduction of the P100 amplitude. The adult pattern of response appears from 24 months onward. Spectral density values show an increase of higher frequencies with age. Coherence values show a reduction between 3 and 23 months of age as well as a further increase toward adulthood between areas implicated in visual processing. These results are discussed in light of developmental features such as synaptogenesis, myelination, and neuronal networks refinement.
Centre de recherche, Hôpital Sainte-Justine, Montréal, QC, Canada.
S
S
Lippé
M-S
MS
Roy
C
C
Perchet
M
M
Lassonde
D000328:Adult; D015415:Biomarkers; D001921:Brain / Q000033:anatomy & histology; D001931:Brain Mapping; D049109:Cell Proliferation; D002675:Child, Preschool; D003463:Cues; D004569:Electroencephalography; D004594:Electrophysiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009778:Occipital Lobe / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation; D013569:Synapses / Q000502:physiology; D014793:Visual Cortex / Q000254:growth & development* / Q000502:physiology*
D015415:Biomarkers