CFTR haplotype distribution in the Brazilian Western Amazonian region.
Two hundred twenty-one individuals from four groups located around the Brazilian town of Porto Velho, Rondônia, were studied in relation to four sites located within or near the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The allele frequencies, when considered individually, do not depart markedly from frequencies obtained from other populations of mainly European descent. However, when haplotypes were estimated, two of the groups departed markedly from other Brazilian and non-Brazilian samples. This finding is probably related to the complex multiethnic origin of these groups.
Instituto de Pesquisa em Patologias Tropicais de Rondônia (IPEPATRO), BR 364, Km 3,5, 78900-970 Porto Velho, RO, Brazil.
M I O
MI
Heckmann
C T
CT
Mendes-Júnior
M S
MS
Tada
M G
MG
Santos
G M K
GM
Cabello
F M
FM
Salzano
A L
AL
Simões
V
V
Engracia
D001938:Brazil; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D012424:Rural Population
D019005:Cystic Fibrosis Transmembrane Conductance Regulator