Endometrial cancer arising in both horns of didelphys uterus in a Down's syndrome woman.
BACKGROUND
There are only few reports of endometrial cancer arising in patients with uterine malformations. Down's syndrome is characterized by a reduced risk of solid tumors, and there are no reports about its correlation with uterine malformations.


METHODS
An endometrial adenocarcinoma arising in both horns of a didelphys uterus of a Down's syndrome woman.


CONCLUSIONS
Uterine malformations and genetical disorders may cause a delayed diagnosis of gynecological cancers. Gynecological examination in asymptomatic patients and differential diagnosis in abnormal uterine bleeding patients should be considered.
Fanfani
Francesco
F
Division of Gynecologic Oncology, Catholic University of Sacred Heart, Campobasso, Italy.
Fagotti
Anna
A
Restaino
Gennaro
G
Guerriero
Massimiliano
M
Scambia
Giovanni
G
D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D016889:Endometrial Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D014599:Uterus / Q000002:abnormalities*