Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development.
Trichinella spiralis creates a unique intracellular habitat in striated muscle. We report that a proteoglycan, syndecan-1, is induced early in infection yet is not essential for habitat development and exerts a modest influence on the immune response. This report is the first to address the requirement for a specific muscle protein in trichinellosis by using mice deficient in the relevant gene.
James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. db225@cornell.edu
Daniel P
DP
Beiting
Pyong Woo
PW
Park
Judith A
JA
Appleton
D000818:Animals; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D032342:Muscle Cells / Q000378:metabolism*; D024510:Muscle Development / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology*; D011509:Proteoglycans / Q000096:biosynthesis*; D053667:Syndecans; D017160:Trichinella spiralis / Q000502:physiology*; D014235:Trichinellosis / Q000378:metabolism* / Q000503:physiopathology
D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053667:Syndecans