[Expression of chemokine receptor CXCR4 and CCR7 in laryngeal carcinoma].
OBJECTIVE
This study was designed to observe the expression of CXCR4 and CCR7 in laryngeal carcinoma tissues in order to primitively clarify the relationship between Chemokine Receptor CCR7 and CXCR4 and the malignity of laryngeal carcinoma. It would be helpful to cure laryngeal carcinoma.


METHODS
We examined the expression of Chemokine Receptor CXCR4 and CCR7 in 30 cases laryngeal carcinoma tissues (experiment group) and 18 cases normal laryngeal tissues (control group)with immunohistochemistry. And qualitative analysis of light microscopy with computer-assisted image system was employed. Then our conclusion was drawn from statistical analysis.


RESULTS
(1) Chemokine Receptor CXCR4 and CCR7 were positively expressed in laryngeal carcinoma tissues while they were negative in the control group. Their expressions were significantly higher than those of control group (P < 0.01).; (2) Chemokine Receptor CXCR4 and CCR7 expression in laryngeal carcinoma declined with the rise of the differentiation grade of laryngeal carcinoma (P < 0.05). The expression of CXCR4 and CCR7 were significantly higher in the group with lymph node metastasis than those without lymph node metastasis (P < 0.01). And the same results appeared between laryngeal carcinoma groups with different clinical stages (P < 0.01).


CONCLUSIONS
Chemokine Receptor CXCR4 and CCR7 are highly expressed in laryngeal carcinoma, and their expression were associated with differentiation grade of laryngeal carcinoma, clinical stage and neck lymph node metastasis.
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. longzhang999@hotmail.com
Long
L
Zhang
Chengzhang
C
Yang
Ming
M
Li
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D054400:Receptors, CCR7 / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000378:metabolism*
C515370:CCR7 protein, human; C527276:CXCR4 protein, human; D054400:Receptors, CCR7; D019718:Receptors, CXCR4