Localized periorbital edema induced by Ibuprofen.
We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria. The reaction developed one hour after ingestion of 200 mg of ibuprofen. No systemic symptoms were observed. No other NSAIDs did not induce symptoms. This patient was able to tolerate doses of ibuprofen after pretreatment with terfenadine. These observations suggest that histamine played a central role in this ibuprofen-induced skin reaction. Treatment with terfenadine enabled the patient to tolerate ibuprofen without experiencing any side effects. To the best of our knowledge, this is the first reported case of periorbital edema induced by ibuprofen.
Palungwachira
Piti
P
Srinakharinwirot University Skin Center, Srinakharinwirot University, Sukhumvit, Bangkok, Thailand.
Palungwachira
Pranee
P
Ogawa
Hideoki
H
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004487:Edema / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects* / Q000627:therapeutic use; D009916:Orbital Diseases / Q000139:chemically induced* / Q000503:physiopathology; D018570:Risk Assessment; D012720:Severity of Illness Index; D018781:Tension-Type Headache / Q000175:diagnosis / Q000188:drug therapy
D007052:Ibuprofen