[The influence of gene polymorphism of the angiotensin-converting enzyme in donor and recipient on the function of renal graft].
BACKGROUND
The gene coding for the angiotensin I-converting enzyme is known for its polymorphism revealed by the presence or absence of a 287-base pair fragment. The question arises whether ACE gene polymorphism in the recipient and donor has any effect on renal graft function.


METHODS
This prospective study enrolled 94 renal graft recipients. 27 ACE donor genotypes were ascertained. Creatinine clearance after cimetidine, laboratory tests, and episodes of acute and chronic rejection were analyzed. None of the recipient genotype subgroups differed significantly as to creatinine clearance. Only in the group of patients not on ACE inhibitors were there significantly higher creatinine concentrations in recipients with II genotype as compared with ID and DD genotypes pooled together. No differences were found between the genotype subgroups as to the frequency of rejection episodes. Ultimately, donor ACE genotype had no effect on graft function.


RESULTS
In conclusion, the I/D genotype is not an independent prognostic factor for renal graft survival during the first four years after transplantation. The use of ACE inhibitors may modify the effect of the genotype on some parameters of renal function.
Kabat-Koperska
Joanna
J
Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych PAM al. Powstańców Wlkp 72, 70-111 Szczecin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D002927:Cimetidine / Q000008:administration & dosage; D003404:Creatinine / Q000493:pharmacokinetics; D005260:Female; D005838:Genotype; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D011446:Prospective Studies; D014019:Tissue Donors
D000806:Angiotensin-Converting Enzyme Inhibitors; D002927:Cimetidine; D003404:Creatinine; D007703:Peptidyl-Dipeptidase A