Total syntheses of hexacyclinol, 5-epi-hexacyclinol, and desoxohexacyclinol unveil an antimalarial prodrug motif.
Xenobe Research Institute, P.O. Box 4073, San Diego, CA 92164-4073, USA. i@xenobe.org
James J
JJ
La Clair
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D010962:Plasmodium berghei / Q000187:drug effects; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000962:Antimalarials; D004852:Epoxy Compounds; D011083:Polycyclic Compounds; D011355:Prodrugs; C469535:hexacyclinol; D010100:Oxygen