Fatty acids and insulin resistance: a perfect storm.
VLDL levels are elevated in type II diabetes, where they contribute to the risk of coronary heart disease. A study by Wolfrum and Stoffel (2006) shows that the forkhead protein Foxa2 stimulates hepatic VLDL production in concert with the coactivator PGC-1beta and that insulin inhibits this process by inactivating Foxa2.
The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Seung-Hoi
SH
Koo
Marc
M
Montminy
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D051542:Hepatocyte Nuclear Factor 3-beta / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D014157:Transcription Factors / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism*
D002352:Carrier Proteins; C496502:FOXA2 protein, human; D005227:Fatty Acids; D007328:Insulin; D008079:Lipoproteins, VLDL; D014157:Transcription Factors; D014280:Triglycerides; C106092:microsomal triglyceride transfer protein; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; C030106:very low density lipoprotein triglyceride; D051542:Hepatocyte Nuclear Factor 3-beta