Hepatic adenomatosis associated with hormone replacement therapy and hemosiderosis: a case report.
We have reported a case of hepatic adenomatosis associated with hormone replacement therapy (estrogen and progesterone) and hemosiderosis caused by excessive blood transfusion for the treatment of chronic myeloid leukemia. A 34-year-old woman was found to have several hepatic tumors on a routine medical examination. The general condition was good. Laboratory studies showed iron overload. Abdominal computed tomography and selective hepatic angiography showed several hypervascular tumors in the right lobe of the liver (up to 20 mm in diameter). Since hepatocellular carcinoma could not be ruled out, subsegmental hepatectomy was performed. Histopathological examination of the surgical specimen showed hepatic adenomatosis with hemosiderosis. Both hormone replacement therapy and iron overload could be the cause of hepatic adenomatosis.
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa, Maebashi, Gunma 371-8511, Japan.
Satoshi
S
Hagiwara
Hitoshi
H
Takagi
Daisuke
D
Kanda
Naondo
N
Sohara
Satoru
S
Kakizaki
Kenji
K
Katakai
Teruo
T
Yoshinaga
Tsugio
T
Higuchi
Kenichi
K
Nomoto
Hiroyuki
H
Kuwano
Masatomo
M
Mori
D000236:Adenoma / Q000209:etiology* / Q000473:pathology; D000328:Adult; D003937:Diagnosis, Differential; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006486:Hemosiderosis / Q000150:complications* / Q000209:etiology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D065227:Transfusion Reaction; D014916:Whole-Body Irradiation / Q000009:adverse effects