Is homocysteine an iron-dependent cardiovascular risk factor?
Recent studies of endothelial function suggest that adverse vascular effects of homocysteine are iron-dependent. Iron sucrose worsens and iron chelation eliminates homocysteine-associated decreases in flow-mediated dialation. There may be no vasculopathic effect of homocysteine without available reactive iron. Iron-dependent amplification of the vascular effects of homocysteine may be one of several mechanisms by which stored iron increases cardiac risk.
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA. jlsullivan@pol.net
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Sullivan
D000328:Adult; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002614:Chelating Agents / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D005293:Ferritins; D006710:Homocysteine / Q000097:blood / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D000090463:Iron Deficiencies; D008297:Male; D008715:Methionine / Q000494:pharmacology / Q000502:physiology; D018384:Oxidative Stress; D011929:Razoxane / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012307:Risk Factors; D012727:Sex Characteristics; D014664:Vasodilation / Q000187:drug effects
D002614:Chelating Agents; D006710:Homocysteine; D011929:Razoxane; D005293:Ferritins; D008715:Methionine; D007501:Iron