Redirecting the coat protein of a spherical virus to assemble into tubular nanostructures.
We take advantage of the self-assembly properties of the coat protein of a spherical virus to form uniform tubular nanostructures. Critical to redirecting assembly are the weak interprotein association energy inherent to virus assembly and the relatively rigid nature of the double-stranded DNA scaffold at their core.
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA.
Santanu
S
Mukherjee
Cory M
CM
Pfeifer
Jennifer M
JM
Johnson
Jay
J
Liu
Adam
A
Zlotnick
D017795:Bromovirus / Q000737:chemistry*; D036022:Capsid Proteins / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D004996:Ethidium / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry*
D036022:Capsid Proteins; D004247:DNA; D004996:Ethidium