Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study.
BACKGROUND
The relation between measures of oxidation of lipid particles and cardiovascular disease has not been extensively investigated prospectively on a population basis.


METHODS
A community cohort of 1192 men and 1427 women with measures of IgG antibodies to oxidized LDL were followed 8 years for the development of initial coronary heart disease (CHD) and cardiovascular disease (CVD) events.


RESULTS
Levels of IgG autoantibodies to a form of oxidized LDL were significantly associated with age in both sexes, positively with fibrinogen in men and negatively with HDL cholesterol in women. In sex-specific models that adjusted for age alone or those that adjusted for age, cholesterol, HDL cholesterol, smoking, and diabetes mellitus, there was no relation between level of antibodies to oxidized LDL and the development of CHD or CVD.


CONCLUSIONS
Autoantibodies to oxidized LDL were strongly related to age and were not related to incident CHD or CVD over 8 years of follow up.
Medical University of South Carolina, 96 Jonathan Lucas St, Suite 815, P.O. Box 250609, Charleston, SC 29425, USA. wilsonpw@musc.edu
Peter W F
PW
Wilson
Ori
O
Ben-Yehuda
Judy
J
McNamara
Joseph
J
Massaro
Joseph
J
Witztum
Peter D
PD
Reaven
D000328:Adult; D032721:Adult Children; D000367:Age Factors; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein