The effect of physician permission versus notification on research recruitment through cancer registries (United States).
OBJECTIVE
To determine how physicians responded when investigators inquired about contacting patients identified through a central cancer registry, and to examine participation rates under physician permission versus notification approaches.


METHODS
We analyzed existing data from seven observational epidemiologic studies conducted in North Carolina between 1993 and 2004, capitalizing on a 'natural experiment' that arose when the state registry changed from a policy requiring investigators to obtain physician permission to one requiring only physician notification.


RESULTS
When a notification approach was used, physicians approved researcher contact with a higher proportion of patients, and a higher proportion of physicians approved contact with or provided eligibility information about all patients requested, compared with a permission approach. Among physicians who were contacted under both approaches, the proportion of patients for whom they approved contact or provided information was significantly higher when they were notified. Physician notification was also associated with higher patient contact and overall response rates. Patient cooperation rates did not differ between the two approaches, suggesting that patients did not respond negatively to the fact that their physician was not explicitly asked to provide permission.


CONCLUSIONS
Notification is likely an efficient way of involving patients' physicians, providing opportunity for physician input but avoiding the burdens associated with requiring their permission.
Beskow
Laura M
LM
Department of Health Policy and Administration, School of Public Health, University of North Carolina, Chapel Hill, USA. laura_beskow@unc.edu
Millikan
Robert C
RC
Sandler
Robert S
RS
Godley
Paul A
PA
Weiner
Bryan J
BJ
Weinberger
Morris
M
D002986:Clinical Trials as Topic; D003299:Cooperative Behavior; D006801:Humans; D009657:North Carolina; D018579:Patient Selection; D010817:Physician-Patient Relations / Q000941:ethics*; D012042:Registries; D012107:Research Design