Modulation of serum cortisol by substance P in albino rats: evidence of a direct effect on adrenal gland.
Effect of prolonged administration of substance P on the plasma cortisol level in the albino rats has been investigated. An inhibitory impact on intact individuals and a stimulatory effect in pharmacologically annulled rats has been observed. It is concluded that in normal conditions substance P presumably acts as a preventive agent for any excess secretion of cortisol while during stress or disturbed HPA or RAS conditions, it stimulates the secretion of cortisol. An intraglandular modulatory role of substance P has been suggested.
Prasad
Anita
A
Department of Zoology, Ranchi University, India.
Naskar
Ranu
R
Dubey
Rakhi
R
Raha
Dipali
D
Ahmed
M Firoz
MF
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000097:blood* / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000473:pathology; D007279:Injections, Subcutaneous; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological / Q000473:pathology / Q000517:prevention & control; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*
D018377:Neurotransmitter Agents; D013373:Substance P; D006854:Hydrocortisone