Nonequilibrium membrane fluctuations driven by active proteins.
We extend a model for nonthermal membrane undulations driven by active (adenosine triphosphate-dependent or light-harvesting) membrane proteins [N. Gov, Phys. Rev. Lett. 93, 268104 (2004)]. The present model accounts for the fact that proteins can diffuse laterally across the membrane surface and that individual proteins are expected to exert forces preferentially in one normal direction over the other (due to their orientation within the bilayer). The addition of these effects alters the scaling of fluctuation amplitudes with system size. Additionally, theoretical arguments and dynamic simulations both suggest that, in certain regimes, the probability distribution of fluctuation amplitudes is expected to be non-Gaussian (in contrast to thermal systems).
Department of Physics, University of California, Santa Barbara, 93106-9530, USA.
Lawrence C-L
LC
Lin
Nir
N
Gov
Frank L H
FL
Brown
D001696:Biomechanical Phenomena; D003198:Computer Simulation; D008051:Lipid Bilayers / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D008954:Models, Biological; D013269:Stochastic Processes
D008051:Lipid Bilayers; D008565:Membrane Proteins