Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish.
The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.
Panagos
Patoula G
PG
Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA.
Dobrinski
Kimberly P
KP
Chen
Xianghong
X
Grant
Amanda W
AW
Traver
David
D
Djeu
Julie Y
JY
Wei
Sheng
S
Yoder
Jeffrey A
JA
D000595:Amino Acid Sequence; D000818:Animals; D002470:Cell Survival / Q000502:physiology; D002875:Chromosomes; D022202:Chromosomes, Artificial, Bacterial; D007694:Killer Cells, Natural / Q000378:metabolism; D037181:Lectins, C-Type / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D008214:Lymphocytes / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D022423:Myeloid Cells / Q000378:metabolism*; D010802:Phylogeny; D015027:Zebrafish / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics* / Q000378:metabolism*
C511064:Illr1 protein, zebrafish; C511065:Illr3 protein, zebrafish; C511066:Illr4 protein, zebrafish; D037181:Lectins, C-Type; D029961:Zebrafish Proteins