Endocervical glandular involvement is associated with high-grade SIL.
OBJECTIVE
To examine whether endocervical glandular involvement (EGI) by squamous intraepithelial lesions (SIL) is associated with the grade of the squamous lesion and to assess the usefulness of such association for diagnostic purposes.


METHODS
Histologic sections from two hundred successive cases of cervical SIL were reviewed retrospectively from the archives of the Department of Pathology of a tertiary care medical center.


RESULTS
Nine of 93 (9.7%) low-grade lesions and 41 of 107 (38.3%) high-grade lesions showed glandular involvement (P = 0.001, Chi-squared test). The relative risk of having EGI in high-grade lesions as compared to low-grade lesions was 3.95.


CONCLUSIONS
EGI is seen approximately four times more frequently in high-grade SIL than in low-grade SIL. Therefore, in cases that are difficult to grade, the presence of EGI is in favor of the lesion being a high-grade SIL.
Nagi
Chandandeep S
CS
Department of Pathology, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1194, New York, NY 10029, USA.
Schlosshauer
Peter W
PW
D019092:Conization; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*