Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men.
Consumption of some dietary fibres may benefit bowel health; however, the effect of Australian sweet lupin (Lupinus angustifolius) kernel fibre (LKFibre) is unknown. The present study examined the effect of a high-fibre diet containing LKFibre on bowel function and faecal putative risk factors for colon cancer compared to a control diet without LKFibre. Thirty-eight free-living, healthy men consumed an LKFibre and a control diet for 1 month each in a single-blind, randomized, crossover study. Depending on subject energy intake, the LKFibre diet was designed to provide 17-30 g/d fibre (in experimental foods) above that of the control diet. Bowel function self-perception, frequency of defecation, transit time, faecal output, pH and moisture, faecal levels of SCFA and ammonia, and faecal bacterial beta-glucuronidase activity were assessed. In comparison to the control diet, the LKFibre diet increased frequency of defecation by 0.13 events/d (P=0.047), increased faecal output by 21 % (P=0.020) and increased faecal moisture content by 1.6 % units (P=0.027), whilst decreasing transit time by 17 % (P=0.012) and decreasing faecal pH by 0.26 units (P<0.001). Faecal butyrate concentration was increased by 16 % (P=0.006), butyrate output was increased by 40 % (P=0.002) and beta-glucuronidase activity was lowered by 1.4 micromol/h per g wet faeces compared to the control diet (P<0.001). Addition of LKFibre to the diet incorporated into food products improved some markers of healthy bowel function and colon cancer risk in men.
School of Exercise and Nutrition Sciences, Faculty of Health and Behavioural Sciences, Deakin University, 221 Burwood Hwy, Burwood, Victoria, 3125, Australia. stukj@deakin.edu.au
Stuart K
SK
Johnson
Veronica
V
Chua
Ramon S
RS
Hall
Amynta L
AL
Baxter
D000328:Adult; D000641:Ammonia / Q000032:analysis; D001835:Body Weight / Q000502:physiology; D003110:Colonic Neoplasms / Q000209:etiology* / Q000378:metabolism; D018592:Cross-Over Studies; D003672:Defecation / Q000502:physiology; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage*; D004435:Eating / Q000502:physiology; D005232:Fatty Acids, Volatile / Q000032:analysis; D005243:Feces / Q000737:chemistry / Q000201:enzymology; D005772:Gastrointestinal Transit / Q000502:physiology; D005966:Glucuronidase / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007422:Intestines / Q000502:physiology*; D031297:Lupinus; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016037:Single-Blind Method
D004043:Dietary Fiber; D005232:Fatty Acids, Volatile; D000641:Ammonia; D005966:Glucuronidase