Matrix metalloproteinases in bone marrow: roles of gelatinases in physiological hematopoiesis and hematopoietic malignancies.
Turnover balance of extracellular matrix (ECM) is a prerequisite for the structural and functional homeostasis of bone marrow (BM) microenvironment. The role of ECM in physiologic hematopoiesis and its pathologic change in hematopoietic malignancies are very important and under extensive investigation. Accumulating evidence suggests that matrix metalloproteinases (MMPs), a family of zinc-dependent proteinases, take an active part in the physiological and pathological hematopoiesis through remodeling the ECM in BM hematopoietic microenvironment. In this review, we will focus on the roles of MMPs in physiological hematopoiesis, hematopoietic stem cells mobilization/transplantation, and hematological malignancies. Furthermore, the preclinical studies on the role of synthetic MMP inhibitors in the treatment of hematological malignancies will be discussed.
Yu
X F
XF
National Research Center for Stem Cell Engineering and Technology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Peking Union of Medical College, Tianjin, China.
Han
Z C
ZC
D000818:Animals; D001853:Bone Marrow / Q000201:enzymology* / Q000503:physiopathology; D016723:Bone Remodeling; D002471:Cell Transformation, Neoplastic; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000201:enzymology / Q000473:pathology / Q000502:physiology; D018093:Gelatinases / Q000502:physiology*; D019337:Hematologic Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000201:enzymology / Q000473:pathology / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000145:classification / Q000502:physiology*
D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D018093:Gelatinases; D020782:Matrix Metalloproteinases