Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations.
Classical Borna disease (cBD), a non-purulent encephalitis of solipeds and sheep, is endemic in certain areas of central Europe. The etiologic agent is Borna disease virus (BDV), thus far the only member of the family Bornaviridae. Based on epidemiological patterns of cBD and recent phylogenetic findings this review hypothesizes the possible existence of yet unknown BDV reservoir host populations, and analyzes critically BDVs from outside endemic regions.
Dürrwald
Ralf
R
Impfstoffwerk Dessau-Tornau GmbH (IDT), Streetzer Weg 15a, D-06862 Rodleben, Germany.
Kolodziejek
Jolanta
J
Muluneh
Aemero
A
Herzog
Sibylle
S
Nowotny
Norbert
N
D000818:Animals; D001890:Borna Disease / Q000453:epidemiology* / Q000821:virology*; D001891:Borna disease virus / Q000235:genetics*; D004197:Disease Reservoirs; D014644:Genetic Variation