Understanding high pressure stability of helical conformation of oligopeptides and helix bundle protein high pressure FT-IR and RISM theoretical studies.
The pressure effect on conformational equilibria of simple organic compounds and the pressure denaturation of proteins have been well investigated by using vibrational spectroscopy. However, there was no systematic investigation of the pressure effect on conformational equilibria of oligopeptides, which are located between the simple organic compounds and proteins. Here, we review the recent vibrational spectroscopic and theoretical studies of the pressure effect on conformational equilibria of model oligopeptides and helix bundle protein in aqueous solution.
Department of Applied Chemistry, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Takahiro
T
Takekiyo
Takashi
T
Imai
Minoru
M
Kato
Yoshihiro
Y
Taniguchi
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry*; D011312:Pressure; D011489:Protein Denaturation; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D009842:Oligopeptides; D011506:Proteins