[The influence of anthocyanins from Aronia melanocarpa on selected parameters of oxidative stress and microelements contents in men with hypercholesterolemia].
OBJECTIVE
Our investigations was to estimate the influence of Aronia anthocyanins (Aronox by Agropharm) on selected parameters of oxidative and antioxidative balance as well as on the concentration of selected metals in red blood cells in men with hipercholesterolaemia.


METHODS
16 men aged 27 +/- 6.4 years old with blood cholesterol concentration on the level of 205-250 mg/dl took 240 mg of anthocyanins a day for 30 days. Before and after the period of anthocyanins administration a blood sample was taken and following parameters were estimated: lead, aluminium, cooper and zinc concentration in erythrocytes with the method of atomic emission spectrometry with induced coupling plasma (AES-ICP), concentration of substances reacting with thiobarbituric acid (TBARS) and superoxide dismutase, glutathione peroxidase and catalase activities in hemolysate.


CONCLUSIONS
30 days long administration of 240 mg of anthocyanins a day, caused a substantial increase of glutathione peroxidase and catalase activities. The lead, aluminium and cooper concentration was decreased while zinc concentration in red blood cells was increased.
Zakład Fizjologii Człowieka i Biofizyki Uniwersytetu Medycznego w Lodzi. farmak@achilles.wam.lodz.pl
Edward
E
Kowalczyk
Paweł
P
Fijałkowski
Marcin
M
Kura
Paweł
P
Krzesiński
Jan
J
Błaszczyk
Jan
J
Kowalski
Janusz
J
Smigielski
Maciej
M
Rutkowski
Maria
M
Kopff
D000328:Adult; D000872:Anthocyanins / Q000494:pharmacology* / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D046936:Photinia; D008517:Phytotherapy / Q000379:methods*; D013858:Thiobarbiturates / Q000378:metabolism; D014131:Trace Elements; D016896:Treatment Outcome
D000872:Anthocyanins; D000975:Antioxidants; D013858:Thiobarbiturates; D014131:Trace Elements; C029684:thiobarbituric acid