A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.
Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.
Waag
David M
DM
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, MD 21702-5011, USA. david.waag@amedd.army.mil
McCluskie
Michael J
MJ
Zhang
Ningli
N
Krieg
Arthur M
AM
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology; D000280:Administration, Inhalation; D000818:Animals; D016470:Bacteremia / Q000276:immunology / Q000517:prevention & control*; D042726:Burkholderia mallei; D005896:Glanders / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D009838:Oligodeoxyribonucleotides / Q000008:administration & dosage* / Q000276:immunology
D000276:Adjuvants, Immunologic; C408982:CPG-oligonucleotide; D009838:Oligodeoxyribonucleotides