Computational and experimental evaluation of the fluid dynamics and hemocompatibility of the CentriMag blood pump.
The CentriMag centrifugal blood pump is a newly developed ventricular assist device based on magnetically levitated bearingless rotor technology. A combined computational and experimental study was conducted to characterize the hemodynamic and hemocompatibility performances of this novel blood pump. Both the three-dimensional flow features of the CentriMag blood pump and its hemolytic characteristics were analyzed using computational fluid dynamics (CFD)-based modeling. The hydraulic pump performance and hemolysis level were quantified experimentally. The CFD simulation demonstrated a clean and streamlined flow field in the main components of the CentriMag blood pump. The predicted results by hemolysis model indicated no significant high shear stress regions in the pump. A comparison of CFD predictions and experimental results showed good agreements. The relatively large gap passages (1.5 mm) between the outer rotor walls and the lower housing cavity walls provide a very good surface washing through a secondary flow path while the shear stresses in the secondary flow paths are reduced, resulting in a low rate of hemolysis ([Normalized Index of Hemolysis] NIH = 0.0029 +/- 0.006) without a decrease of the pump's hydrodynamic performance (pressure head: 352 mm Hg at a flow rate of 5.0 L/min and a rotational speed of 4,000 rpm).
Zhang
Juntao
J
Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA.
Gellman
Barry
B
Koert
Andrew
A
Dasse
Kurt A
KA
Gilbert
Richard J
RJ
Griffith
Bartley P
BP
Wu
Zhongjun J
ZJ
D001698:Biomedical Engineering; D002498:Centrifugation; D003198:Computer Simulation; D006353:Heart-Assist Devices; D006461:Hemolysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008280:Magnetics; D008954:Models, Biological; D011474:Prosthesis Design; D012212:Rheology