[Role of opiate peptides in regulation of the lymphocyte proliferative activity in patients with dyscirculatory encephalopathy in the late period after irradiation].
The authors have studied the endorphins effects on lymphocyte proliferation of 55 Chernobyl male workers aged 36-69 yrs and exposed to radiation dosed from 0.25 to 3.8 Sv. These patients have been found to have discirculatory encephalopathy in comparison with 30 non-exposed workers and 25 healthy volunteers. Physiological concentrations of alpha- and beta-endorphins intensify the spontaneous and mitogen-dependent proliferation of T-lymphocytes. Intensifying effect of the opiate peptides is being blocked by naloxone. Obtained data demonstrate the unidirectional opiates action, however the beta-endorphine effect dominates. The detected effect of endorhines are shown both among exposed to ionizing radiation and non-exposed. The irradiation higher than 1 Sv results in disturbance of the endorphine reception by T-cells with blockage of the influence of naloxone. It confirms the presence of radiation effects in opiate regulation of the lymphocyte proliferation.
Holiarnyk
N A
NA
Bazyka
D A
DA
D000328:Adult; D000368:Aged; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000528:radiation effects*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000209:etiology / Q000276:immunology*; D047852:Chernobyl Nuclear Accident; D006801:Humans; D008875:Middle Aged; D018847:Opioid Peptides / Q000494:pharmacology / Q000502:physiology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D013997:Time Factors; D014455:Ukraine
D018847:Opioid Peptides