Phototoxic activity of a thiophene polyacetylene from Leuzea carthamoides.
The thiophene polyacetylene (E)-1-[5-(hept-5-en-1,3-diynyl)-2-thienyl]ethan-1,2-diol, isolated from the roots of Leuzea carthamoides, showed phototoxic activity in the assay systems of histidine photo-oxidation, Artemia and Tubifex assays. The effects were compared with the standard photosensitizer xanthotoxin.
Chobot
Vladimír
V
Department of Pharmaceutical Botany and Ecology, Charles University, Faculty of Pharmacy, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. vladimir.chobot@faf.cuni.cz
Vytlacilová
Jitka
J
Kubicová
Lenka
L
Opletal
Lubomír
L
Jahodár
Ludek
L
Laakso
Into
I
Vuorela
Pia
P
D000818:Animals; D001156:Artemia / Q000187:drug effects*; D000431:Ethanol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006639:Histidine / Q000378:metabolism; D007928:Lethal Dose 50; D043843:Leuzea / Q000737:chemistry / Q000633:toxicity*; D008730:Methoxsalen / Q000737:chemistry; D009835:Oligochaeta / Q000187:drug effects*; D010084:Oxidation-Reduction / Q000187:drug effects; D017319:Photosensitizing Agents / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D014466:Ultraviolet Rays
D017319:Photosensitizing Agents; D010936:Plant Extracts; D013876:Thiophenes; C511103:thiophene polyacetylene (E)-1-(5-(hept-5-en-1,3-diynyl)-2-thienyl)ethan-1,2-diol; D000431:Ethanol; D006639:Histidine; D008730:Methoxsalen