[Effects of intrinsic denervation of the jejunum after extensive enterectomy in the rat bowel syndrome].
OBJECTIVE
To investigate the effects of intrinsic denervation of the jejunum after the extensive intestinal resection in rats.


METHODS
Thirty male Wistar rats were distributed into three groups, depending on the experimental procedure: Group C (control), Group R (resection) and Group D (resection plus denervation). The body weight gain and a histomorphometric study of the jejunal mucosa were performed.


RESULTS
The mean body weight of the group D animals showed a higher increase when compared to group R (D=312.2+/-21 g and R=196.7+/-36.2g). The number of jejunum myenteric neurons was smaller in group D (344.8+/-34.8 neurons/mm) when compared to other groups (R=909.0+/-55.5 and C=898.5+/-73.3). A hyperplasia of the jejunum mucosal epithelium was observed in the group D but also in the group R (R=7.3+/-3.9 mm2 and D=10.8+/-4.3 mm2), when compared to group C (C=5.8+/-3.0 mm2). The epithelial cell proliferation of the jejunum was higher in group D animals (48.7%) when compared to the other groups (R=31.9% and C=23.6%).


CONCLUSIONS
The denervated animals presented an increase the body weight gain and mucosal cell proliferation responses when compared to the control group. This experimental model may provide new strategies for the surgical treatment of the short bowel syndrome.
Departamento de Patologia, Faculdade de Medicina de Ribeirão, USP.
Carlos Eduardo Verdiani de
CE
Carvalho
Filipe Volpe D'Angieri
FV
Basile
Marcelo Vinícius Oliveira
MV
Vespúcio
Antonio Carlos Garrido
AC
Iglesias
Nelson Fabrício
NF
Gava
Sérgio Britto
SB
Garcia
D000818:Animals; D001597:Benzylidene Compounds / Q000494:pharmacology; D003714:Denervation / Q000379:methods; D004195:Disease Models, Animal; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D007583:Jejunum / Q000294:innervation* / Q000473:pathology / Q000601:surgery; D009197:Myenteric Plexus / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D009752:Nutritional Status / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012778:Short Bowel Syndrome / Q000473:pathology / Q000601:surgery*; D018709:Statistics, Nonparametric; D015996:Survival Rate; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D001597:Benzylidene Compounds; C032732:benzal chloride