Hydroxyl radical scavenging reactivity of proton pump inhibitors.
In addition to the established control of acid secretion of the class of proton pump inhibitors (PPI) reactivity from the pyridyl methyl sulphinyl benzimidazole type a second independent anti-inflammatory reactivity was observed in vitro. This inhibitory reactivity was clearly noticed using three different assays where the aggressive hydroxyl radicals were successfully trapped in a concentration dependent manner. There is unequivocal evidence that the proton pump inhibitors having the sulphoxide group are able to scavenge hydroxyl radicals which are generated during a Fenton reaction. By way of contrast, the corresponding thioethers were substantially less active. No detectable effect was seen in the superoxide radical scavenging system. In conclusion, pantoprazole as well as the other proton pump inhibitors have a pronounced inhibitory reactivity towards hydroxyl radicals.
Simon
Wolfgang Alexander
WA
ALTANA Pharma AG, Byk Guldenstrasse 2, D 78464 Konstanz, Germany. simon@altanapharma.com
Sturm
Ernst
E
Hartmann
Hans-Jürgen
HJ
Weser
Ulrich
U
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry*; D002417:Cattle; D019327:Copper Sulfate / Q000737:chemistry; D003855:Deoxyribose / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry; D004912:Erythrocytes; D016166:Free Radical Scavengers / Q000737:chemistry*; D006418:Heme / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry*; D058085:Iron Compounds / Q000737:chemistry; D064747:Lansoprazole; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000737:chemistry; D000077402:Pantoprazole; D017494:Proton Pumps / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry; D013454:Sulfoxides / Q000737:chemistry*
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D058085:Iron Compounds; D017494:Proton Pumps; D013440:Sulfides; D013454:Sulfoxides; D064747:Lansoprazole; D017665:Hydroxyl Radical; D006418:Heme; D003855:Deoxyribose; D006820:Hyaluronic Acid; D000077402:Pantoprazole; D009853:Omeprazole; D019327:Copper Sulfate