Coxsackie B viruses and the kidney--a neglected topic.
Coxsackie B viruses types 1-6 (CVB1-6) occur worldwide and cause a broad spectrum of diseases, including myocarditis and aseptic meningitis. Although renal damage due to CVB has been suspected since the 1950s, these agents are only rarely searched for in today's clinical nephrological practice. Nevertheless, CVB can infect mesangial cells. Furthermore, infections with these viruses lead to a histological picture resembling mesangioproliferative glomerulonephritis and IgA-nephropathy in mice. In the present article, we provide an overview of this largely neglected topic, and of the slowly and steadily increasing evidence suggesting a link between coxsackieviral infections and kidney diseases.
Pasch
Andreas
A
Frey
Felix J
FJ
D000818:Animals; D015331:Cohort Studies; D003384:Coxsackievirus Infections / Q000150:complications* / Q000175:diagnosis; D004195:Disease Models, Animal; D018450:Disease Progression; D029822:Enterovirus B, Human / Q000302:isolation & purification*; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000821:virology*; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D051379:Mice; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index