The effect of epigenetic sperm abnormalities on early embryogenesis.
Sperm are a highly specialized cell type derived to deliver the paternal haploid genome to the oocyte. The epigenetic, or gene regulatory, properties and mechanisms of the sperm assist in preparation of the paternal genome to contribute to embryogenesis and the genome of the zygote. Many recent studies have addressed the issue of altered epigenetic processes in the sperm. This review evaluates the current understanding of DNA damage, chromosome aneuploidy, reduced telomere length, malformations of the centrosome, genomic imprinting errors, altered mRNA profiles, and abnormal nuclear packaging in the sperm prior to fertilization and the observed effects on embryogenesis. Attention has also been given to understanding the underlying etiology of sperm with altered epigenetic mechanisms in humans.
IVF and Andrology Laboratories, School of Medicine, University of Utah, Salt Lake City, Utah 84108, USA.
Benjamin R
BR
Emery
Douglas T
DT
Carrell
D000782:Aneuploidy; D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D018385:Centrosome / Q000473:pathology; D004249:DNA Damage / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology*; D044127:Epigenesis, Genetic; D018392:Genomic Imprinting / Q000502:physiology; D006801:Humans; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D012333:RNA, Messenger / Q000502:physiology; D013094:Spermatozoa / Q000002:abnormalities* / Q000502:physiology; D016615:Telomere / Q000235:genetics
D012333:RNA, Messenger