The evolving role of proteomics in the early detection of breast cancer.
There has been emerging interest in the examination of tumor protein expression (proteomics) as a means to identify novel diagnostic and therapeutic targets in women with breast cancer. Specifically, several investigators have examined biological fluids (serum and breast ductal fluid) and breast tissue in an attempt to detect novel proteomic profiles in women with breast carcinoma. The current tools of proteomic research are evolving, but include two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Initial studies have identified several unique biomarkers and proteomic profiles that were able to discriminate between non-cancer and breast cancer patients. In the future, the application of large-scale proteomic technology may provide a means of early detection, surveillance, and identification of potential therapeutic targets.
Department of Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Timothy M
TM
Pawlik
Henry M
HM
Kuerer
D014408:Biomarkers, Tumor / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D045604:Extracellular Fluid / Q000737:chemistry; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D020543:Proteome
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D020543:Proteome