The clinical impact of vehicle technology using a patented formulation of benzoyl peroxide 5%/clindamycin 1% gel: comparative assessments of skin tolerability and evaluation of combination use with a topical retinoid.
A major challenge encountered in clinical practice in patients with acne vulgaris is irritation related to topical medications used for treatment. Advances in vehicle technology have improved formulations containing active ingredients known to produce irritation in some patients, such as benzoyl peroxide (BP) and topical retinoids. Clinical studies, including combination therapy studies have demonstrated that certain additives, such as silicates and specific humectants, reduce irritation by maintaining barrier integrity. A patented gel formulation of BP 5%/clindamycin phosphate 1% (clindamycin) containing dimethicone and glycerin has been studied both as a monotherapy and in combination with topical retinoid use. This article evaluates specific vehicle additives included in this gel formulation and explains their role in reducing irritation. Data from clinical trials utilizing this technology in acne management are also reviewed.
Del Rosso
James Q
JQ
Department of Dermatology, University of Nevada School of Medicine, Las Vegas, NV, USA. doctorskin777@yahoo.com
Tanghetti
Emil
E
D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000900:Anti-Bacterial Agents; D001585:Benzoyl Peroxide; D002626:Chemistry, Pharmaceutical; D002981:Clindamycin / Q000031:analogs & derivatives*; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D005260:Female; D005782:Gels; D006801:Humans; D015337:Multicenter Studies as Topic; D017060:Patient Satisfaction; D014677:Pharmaceutical Vehicles; D016032:Randomized Controlled Trials as Topic; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005782:Gels; D014677:Pharmaceutical Vehicles; D012176:Retinoids; D002981:Clindamycin; C007084:clindamycin phosphate; D001585:Benzoyl Peroxide