Rosai-Dorfman disease presenting as bilateral eyelid swellings.
OBJECTIVE
To report a case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) in an extranodal site with unusual presentation.


METHODS
A 19-year-old girl presented with bilateral upper eyelid swellings of 2 years duration due to tumor. The masses were excised and sent for histopathological examination. Microscopic examination revealed similar features in both masses in the form of a collection of large histiocytic cells showing emperipolesis (lymphocytophagocytosis). The histiocytic cells stained positively with S-100 protein and CD68. The background comprised small lymphocytes and plasma cells. Based on the overall features a diagnosis of sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease was made.


CONCLUSIONS
The present case highlights one of the forms in which extranodal Rosai-Dorfman disease can manifest itself. It is important to keep this differential diagnosis in mind whenever such histopathological features are encountered.
Jogai
Sanjay
S
Department of Histopathology, Hussain Makki Juma Centre for Specialised Surgeries, Kuwait. sanjayjogai@rediffmail.com
Temmim
Labiba
L
Al-Baghli
Abdullah
A
Adesina
Aaron Olaolu
AO
D000328:Adult; D003937:Diagnosis, Differential; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome