Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization.
Citalopram, a selective serotonin reuptake inhibitor (SSRI), is one of the most widely used antidepressants. Recently, citalopram has been reported to improve working memory in patients with depression, and psychotic symptoms and behavioral disturbances in patients with dementia. However, the possibility of using citalopram in the treatment of cognitive disorders has not received much attention. The present study investigated the effects of citalopram on scopolamine- and Delta9-tetrahydrocannabinol (THC)-induced impairment of spatial memory using an eight-arm radial maze and electroconvulsive shock (ECS)-induced immobilization (a behavioral model for the disturbance of consciousness). Low dose citalopram reversed both scopolamine- and THC-induced impairment of spatial memory, suppressed ECS-induced immobilization reversed the THC-induced decrease of acetylcholine (ACh) release in the dorsal hippocampus in vivo microdialysis, and enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that low dose citalopram is useful for the treatment of memory deficits and consciousness disturbance.
Egashira
Nobuaki
N
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Matsumoto
Yoshiaki
Y
Mishima
Kenichi
K
Iwasaki
Katsunori
K
Fujioka
Masayuki
M
Matsushita
Michihiko
M
Shoyama
Yukihiro
Y
Nishimura
Ryoji
R
Fujiwara
Michihiro
M
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D015283:Citalopram / Q000008:administration & dosage / Q000627:therapeutic use*; D013759:Dronabinol; D004597:Electroshock; D006213:Hallucinogens; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D017551:Microdialysis; D018721:Muscarinic Agonists; D010095:Oxotremorine; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D014202:Tremor / Q000139:chemically induced / Q000503:physiopathology
D015283:Citalopram; D013759:Dronabinol; D006213:Hallucinogens; D018721:Muscarinic Agonists; D010095:Oxotremorine; D012601:Scopolamine; D017367:Selective Serotonin Reuptake Inhibitors