Hydroxylation of lansoprazole in poor metabolizers of CYP2C19.
Furuta
Takahisa
T
Shirai
Naohito
N
Sugimoto
Mitsushige
M
Nakamura
Akiko
A
Hishida
Akira
A
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D065731:Cytochrome P-450 CYP2C19; D004791:Enzyme Inhibitors / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D064747:Lansoprazole; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000378:metabolism
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D004791:Enzyme Inhibitors; D064747:Lansoprazole; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D009853:Omeprazole