Disseminated Kikuchi-Fujimoto disease: a case report.
Subacute necrotizing lymphadenitis or Kikuchi-Fujimoto disease is a benign pathological entity diagnosed chiefly in young adults. We report a case in a 20-year-old woman who presented with swollen lymph nodes and a fever. Disseminated lymphadenopathy with nodes measuring up to 6 cm in diameter was found upon physical examination. The erythrocyte sedimentation rate was elevated to 40 mm/h and the lactic dehydrogenase level to 593 IU/l. Findings were negative from serological tests for rubella, hepatitis B, hepatitis C, HIV, and toxoplasmosis, as well as from tests for tuberculosis. A biopsy of a cervical lymph node showed nonsuppurative necrosis, karyorrhexis, and a marked histiocytic reaction consistent with Kikuchi-Fujimoto disease. No treatment was given, and a full recovery was achieved within 3 months. In this patient, the disseminated lymphadenopathy and constitutional symptoms strongly suggested a hematological malignancy and more specifically a lymphoproliferative disease.
Hematology Department, Hédi Chaker Hospital Sfax, Tunisia. sondes.mseddi@rns.tn
Sondes
S
Mseddi
Salwa
S
Makni
Moez
M
Elloumi
Tahia
T
Boudawara
Mounir
M
Frikha
Taoufik
T
Souissi
D000328:Adult; D001799:Blood Sedimentation; D005260:Female; D006644:Histiocytes / Q000473:pathology; D020042:Histiocytic Necrotizing Lymphadenitis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009336:Necrosis