Substrate specificity of strictosidine synthase.
Strictosidine synthase catalyzes a Pictet-Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway.
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Elizabeth
E
McCoy
M Carmen
MC
Galan
Sarah E
SE
O'Connor
D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism; D019759:Carbon-Nitrogen Lyases / Q000737:chemistry*; D002384:Catalysis; D004789:Enzyme Activation; D005959:Glucosidases / Q000737:chemistry; D026121:Indole Alkaloids / Q000737:chemistry; D007211:Indoles / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism; D014748:Vinca Alkaloids / Q000096:biosynthesis / Q000737:chemistry
D000470:Alkaloids; D026121:Indole Alkaloids; D007211:Indoles; D013729:Terpenes; D014748:Vinca Alkaloids; C021093:strictosidine; D005959:Glucosidases; C456847:strictosidine glucosidase; D019759:Carbon-Nitrogen Lyases; C022684:strictosidine synthetase