Repetitive transcranial magnetic stimulation-induced changes in sensorimotor coupling parallel improvements of somatosensation in humans.
Repetitive transcranial magnetic stimulation (rTMS) is an established technique for non-invasive stimulation of human cortex. Although studies have shown an influence of rTMS on single cortical regions and on simple behavioral response patterns, its influences on the dynamics of task-related activity in cortical networks have not been characterized. We provide such a characterization by showing that 5 Hz rTMS over primary somatosensory cortex (SI) induces a reconfiguration of activity patterns in a sensorimotor network, comprising the stimulated region and ipsilateral primary motor cortex (MI). These plastic changes endure for up to 120 min and are correlated with behavioral improvement in discrimination. Dynamic causal modeling showed that this reconfiguration could be explained by an rTMS-induced increase in SI excitability (self-connection) and an increase in the effective connectivity from SI to MI. Thus, our data demonstrate that rTMS can temporarily induce behaviorally relevant reorganization within a complex cortical network underlying human somatosensory experience.
Pleger
Burkhard
B
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom. b.pleger@fil.ion.ucl.ac.uk
Blankenburg
Felix
F
Bestmann
Sven
S
Ruff
Christian C
CC
Wiech
Katja
K
Stephan
Klaas E
KE
Friston
Karl J
KJ
Dolan
Raymond J
RJ
D000328:Adult; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D010465:Perception / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D012016:Reference Values; D013003:Somatosensory Cortex / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*