Acute tubular necrosis associated with chromium picolinate-containing dietary supplement.
OBJECTIVE
To report a case of acute tubular necrosis associated with the use of a chromium picolinate-containing dietary supplement.


METHODS
A 24-year-old white male who had been ingesting a dietary supplement (Arsenal X) for 2 weeks during his workout sessions developed acute renal failure. Radiologic investigation showed the presence of a solitary right kidney, and an open renal biopsy confirmed features of acute tubular necrosis. He developed significant renal impairment that required hemodialysis. He was also treated with plasmapheresis and steroids, as a diagnosis of pulmonary-renal syndrome was entertained early in the disease course, which was subsequently ruled out. The patient ultimately recovered and, on outpatient visits, was noted to have normal renal function.


CONCLUSIONS
The use of dietary supplements has become increasingly popular in the US, and these supplements are not subject to stringent premarketing testing or postmarketing surveillance. The main ingredients in the supplement discussed here were chromium picolinate, Sida cordifolia, synephrine, and guarana. An objective causality assessment using the Naranjo probability scale indicated a probable association between the use of this supplement and the development of acute renal failure in this patient.


CONCLUSIONS
Current information regarding the beneficial effects of trivalent chromium is not very robust; therefore, use of this agent cannot be recommended at this time. This report serves as an important reminder to the public, as well as healthcare providers, of potential nephrotoxic reactions to dietary supplements.
Wani
Sachin
S
BryanLGH Medical Center, Internal Medicine, University of Nebraska Medical Center, Lincoln, 68502, USA. sachinwani10@yahoo.com
Weskamp
Celia
C
Marple
Jeffrey
J
Spry
Leslie
L
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019587:Dietary Supplements / Q000009:adverse effects*; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010848:Picolinic Acids / Q000009:adverse effects*; D010956:Plasmapheresis; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed
D000893:Anti-Inflammatory Agents; D010848:Picolinic Acids; C030614:picolinic acid