Approaches to functional genomics in filamentous fungi.
The study of gene function in filamentous fungi is a field of research that has made great advances in very recent years. A number of transformation and gene manipulation strategies have been developed and applied to a diverse and rapidly expanding list of economically important filamentous fungi and oomycetes. With the significant number of fungal genomes now sequenced or being sequenced, functional genomics promises to uncover a great deal of new information in coming years. This review discusses recent advances that have been made in examining gene function in filamentous fungi and describes the advantages and limitations of the different approaches.
National Centre for Advanced Bio-Protection Technologies, PO Box 84, Lincoln University, Canterbury 8150, New Zealand. weldr@lincoln.ac.nz
Richard J
RJ
Weld
Kim M
KM
Plummer
Margaret A
MA
Carpenter
Hayley J
HJ
Ridgway
D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D005658:Fungi / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D005819:Genetic Markers; D005821:Genetic Techniques; D016681:Genome, Fungal; D023281:Genomics; D016254:Mutagenesis, Insertional; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D040901:Proteomics; D034622:RNA Interference; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014170:Transformation, Genetic
D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005819:Genetic Markers; C036483:T-DNA