Synthesis and characterization of monosaccharide lipids as novel hydrogelators.
Self-assembly of small molecules is a useful strategy for forming functional supramolecular structures. Three new series of methyl alpha-D-glucopyranoside derivatives, including esters and carbamates, have been synthesized and characterized. Several of these compounds are excellent hydrogelators and formed interesting self-assembled network structures, including birefringent fibers and tubules. The gelation properties depend on the acyl chain length and the headgroup structures. Small molecule sugar-based hydrogelators have potential applications in drug delivery and enzyme immobilization.
Wang
Guijun
G
Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA. gwang2@uno.edu
Cheuk
Sherwin
S
Williams
Kristopher
K
Sharma
Vibha
V
Dakessian
Lousi
L
Thorton
Zeus
Z
D016503:Drug Delivery Systems; D004800:Enzymes, Immobilized; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry*
D004800:Enzymes, Immobilized; D008055:Lipids; D009005:Monosaccharides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate