A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa.
The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent global transcriptome and proteome analyses provided a wealth of information about the identity of the regulated genes, N-acyl-homoserine lactone signal specificity, timing of induction, and environmental effects on gene expression. Quorum-sensing gene expression in P. aeruginosa is also embedded in a highly interconnected network of other regulatory systems with a high potential for integrating and responding to multiple environmental signals. Such epigenetic complexity may constitute the basis for the exceptional adaptability of P. aeruginosa to diverse environments.
Department of Microbiology, University of Washington, 1959 NE Pacific Street, HSB I-420, Seattle, WA 98195, USA.
Martin
M
Schuster
E Peter
EP
Greenberg
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000502:physiology; D002265:Carboxylic Ester Hydrolases / Q000235:genetics; D002450:Cell Communication / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
C088386:homoserine lactone; D002265:Carboxylic Ester Hydrolases; C432003:N-acyl homoserine lactonase; D015107:4-Butyrolactone