Experience increases the prepulse inhibition of the acoustic startle response in mice.
The authors have previously shown that inhibition of the acoustic startle response by a prepulse increases when it is repetitively elicited over days. The present experiments show in C3H and C57 mice that this change is caused by an increase in prepulse inhibition (PPI) and not by a decrease in prepulse facilitation. This PPI increase is only evoked if prepulses and startle stimuli are repeatedly given in a temporally paired ("contingent") order, proposing an associative learning process. (Only in C57 mice, PPI was additionally increased by adaptation in the same, but not in a different, context). As an underlying mechanism for this PPI increase by experience, the authors hypothesize Hebbian plasticity of an inhibitory synapse.
Plappert
Claudia F
CF
Institute of ZoologyDepartment of Animal Physiology, University of Tübingen, Tübingen, Germany. claudia.plappert@uni-tuebingen.de
Kuhn
Stephanie
S
Schnitzler
Hans-Ulrich
HU
Pilz
Peter K D
PK
D000161:Acoustic Stimulation / Q000379:methods*; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D006185:Habituation, Psychophysiologic; D007266:Inhibition, Psychological; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013216:Reflex, Startle / Q000502:physiology*; D013997:Time Factors