[Serious bleeding in systemic lupus erythematosus complicated by lupus anticoagulant-hypoprothrombinaemia syndrome].
Severe hemorrhagic diathesis due to lupus anticoagulant complicated by hypoprothrombinaemia resulting from prothrombin autoantibodies is a rare disorder and is often associated with systemic lupus erythematosus (SLE). We report a case in which a 15-year-old girl with SLE developed marked haemorrhagic manifestations due to menorrhagia and nosebleeds. The acute bleeding episode was treated with SAGM, tranexamic acid and recombinant factor VIIa. Lupus anticoagulant, cardiolipin antibodies and antiprothrombin antibodies were successfully depressed within weeks after corticosteroid therapy was begun.
Sixtus Thorsen H:S Rigshospitalet, Klinisk Biokemisk Afdeling KB, Diagnostisk Center og Juliane Marie Centret, Paediatrisk Klinik II. jyen@gentoftehosp.kbhamt.dk
Jytte
J
Engelsen
Susan M
SM
Nielsen
Sixtus
S
Thorsen
D000293:Adolescent; D004844:Epistaxis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008595:Menorrhagia / Q000188:drug therapy / Q000209:etiology / Q000276:immunology
D016682:Lupus Coagulation Inhibitor