[The pharmacokinetic study on cytarabine nanoparticle lyophilization injection in rabbits].
OBJECTIVE
The pharmacokinetics of Cytarabine Polybutylcyanoacrylate Nanoparticles (Ara-C-PBCA-NP) lyophilization injection in rabbits was studied.


METHODS
Ara-C water solution was taken as reference, the concentration of Ara-C was determined by HPLC, and the pharmacokinetic parameters were calculated.


RESULTS
Pharmacokinetic properties of Ara-C water solution and Ara-C-PBCA-NP lyophilization injection complied with two-department model. The parameters t1/2 beta and MRT of Ara-C-PBCA-NP lyophilization injection were prolonged, and CL was reduced dramatically (P < 0.05).


CONCLUSIONS
Ara-C-PBCA-NP lyophilization injection possesses prolonged retention time in vivo and significant sustained releasing character.
Department of Clinical Pharmacy, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Jing
J
Zhou
Xue-hua
XH
Jiang
Lin
L
He
Chen-rui
CR
Li
Jun-yi
JY
Yang
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D003561:Cytarabine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods; D004659:Enbucrilate / Q000737:chemistry; D005612:Freeze Drying; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D053758:Nanoparticles; D011817:Rabbits
D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D003561:Cytarabine; D004659:Enbucrilate