Symmetrical bisquinolones via metal-catalyzed cross-coupling and homocoupling reactions.
Functionalized 4,4'-bisquinolones can be efficiently synthesized by microwave-assisted palladium(0)-catalyzed one-pot borylation/Suzuki cross-coupling reactions or via nickel(0)-mediated homocouplings of 4-chloroquinolin-2(1H)-one precursors. Both methods are also applicable to other types of symmetrical biaryls.
Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
Jamshed
J
Hashim
Toma N
TN
Glasnov
Jennifer M
JM
Kremsner
C Oliver
CO
Kappe
D002384:Catalysis; D008872:Microwaves; D009532:Nickel; D010165:Palladium; D015363:Quinolones / Q000138:chemical synthesis*
D015363:Quinolones; D010165:Palladium; D009532:Nickel