The effects of exercise training on myocardial adrenergic and muscarinic receptors.
We investigated the effects of exercise training on heart rate variability (HRV) and myocardial adrenergic and muscarinic receptors in rats. Exercise training induced a decrease in body mass while ventricular size remained unchanged, a development we considered as a relative cardiac hypertrophy. In addition, there was a reduction in the density of myocardial beta(1)-adrenergic receptors. These structural changes were associated with functional adaptations, as illustrated by the increased response of the sinus node to sympathetic blockade.
Barbier
Julie
J
Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2, Av. Charles Tillon, 35044 Rennes Cedex, France. julie.barbier@uhb.frt
Reland
Sylvia
S
Ville
Nathalie
N
Rannou-Bekono
Françoise
F
Wong
Sara
S
Carré
François
F
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D015992:Body Mass Index; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000033:anatomy & histology; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D009929:Organ Size; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D018342:Receptors, Adrenergic, beta-1 / Q000032:analysis*; D011976:Receptors, Muscarinic / Q000032:analysis*; D012849:Sinoatrial Node / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D018342:Receptors, Adrenergic, beta-1; D011976:Receptors, Muscarinic