Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms.
There is compelling evidence that Alzheimer's disease (AD) amyloid-beta (Abeta) deposition is associated with a local inflammatory response, which is initiated by the activation of microglia and the recruitment of astrocytes. These cells secrete a number of cytokines and neurotoxic products that may contribute to neuronal degeneration and cell death. It has been documented that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs) decrease the risk for developing AD and delay the onset of the disease. The mechanism behind these NSAIDs is still controversial and several hypotheses have been raised, including changes in the amyloid precursor protein (APP) metabolism, in Abeta aggregation and a decrease in inflammatory mediators. Recently, it was proposed that some NSAIDs might activate the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). PPAR-gamma belongs to a family of nuclear receptors that are able to regulate the transcription of pro-inflammatory molecules, such as iNOS. The activation of PPAR-gamma has been recently reported to reduce Abeta levels in cell culture and AD animal models. The implication of PPAR-gamma in the control of Abeta-induced inflammation suggests a new target for AD therapy and emphasize the contribution of neuroinflammatory mechanisms to the pathogenesis of AD.
Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. magdalena.sastre@ukb.uni-bonn.de
Magdalena
M
Sastre
Thomas
T
Klockgether
Michael T
MT
Heneka
D000544:Alzheimer Disease / Q000150:complications* / Q000378:metabolism* / Q000517:prevention & control; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004660:Encephalitis / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D056913:Mediator Complex Subunit 1; D017628:Microglia / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D014157:Transcription Factors / Q000502:physiology
D016229:Amyloid beta-Peptides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018925:Chemokines; D016207:Cytokines; C538855:MED1 protein, human; D056913:Mediator Complex Subunit 1; D014157:Transcription Factors