A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines.
Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process.
Dunsmore
Colin J
CJ
School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, U.K.
Carr
Reuben
R
Fleming
Toni
T
Turner
Nicholas J
NJ
D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D001234:Aspergillus niger / Q000201:enzymology; D008995:Monoamine Oxidase / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism
D000588:Amines; D008995:Monoamine Oxidase