Overcoming roadblocks in lead optimization: a thermodynamic perspective.
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Adam J
AJ
Ruben
Yoshiaki
Y
Kiso
Ernesto
E
Freire
D000818:Animals; D015195:Drug Design; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D011485:Protein Binding; D013816:Thermodynamics