Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation.
Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D3 [1,25-(OH)2D3], a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the 1,25-(OH)2D3]-induced HL-60 cell differentiation.
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
Seung Hyun
SH
Kim
Sun Young
SY
Chung
Tae Sung
TS
Kim
Bo Gil
BG
Choi
D002117:Calcitriol / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009580:Nitroblue Tetrazolium; D012500:Santonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
D007202:Indicators and Reagents; D014815:Vitamins; D012500:Santonin; D009580:Nitroblue Tetrazolium; D002117:Calcitriol