[Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration].
OBJECTIVE
To study pharmacokinetics of breviscapine in dogs and rabbits after iv. single dose.


METHODS
Lc/Lc extract was used to prepare test samples and HPLC was used to determine breviscapine.


RESULTS
Breviscaplin was fitted to double-department model in dogs and rabbits after iv. single dose. The main parameters in dogs were: A = 56.93 +/- 23.14, B = 1.61 +/- 1.11, alpha = 0.2328 +/- 0.1321 min, beta = 0.0255 +/- 0.0187 min(-1), t(1/2alpha) = 2.98 +/- 1.42 min, t(1/2beta) = 27.14 +/- 14.35 min, K21 = 0.10312 +/- 0.0112 min(-1), K10 = 0.1904 +/- 0.1319 min(-1), K12 = 0.0367 +/- 0.0306 min(-1), CL = 39.41 +/- 20.44 ml x min(-1), AUC = 3074 +/- 1055 mg x min x L(-1), respectively. The main parameters in rabbits were:A = 2.64 +/- 1.12, B = 0.28 +/- 0.12, alpha = 0.1439 +/- 0.0681 min(-1), beta = 0.0162 +/- 0.0456 min(-1), t1/2alpha = 4.82 +/- 1.65 min, th1/2beta = 42.66 +/- 18.77 min, K21 = 0.0285 +/- 0.0147 min(-1), K10 = 0.0820 +/- 0.00378 min(-1), K12 = 0.0496 +/- 0.0241 min, CL = 337.05 +/- 156.48ml x min(-1), AUC = 356 +/- 114 mg x min x L(-1), respectively.


CONCLUSIONS
Breviscapine has short half-life after intravenous administration to dogs and rabbits,which show breviscapine is eliminated rapidly and has short action time.
Institute of Material Medica, Tsinghua University, Beijing 100084.
Qingfei
Q
Liu
Guoan
G
Luo
Yiming
Y
Wang
Yuhui
Y
Ma
Rongli
R
Zhang
D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004285:Dogs; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D049919:Erigeron / Q000737:chemistry*; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D000432:Methanol; D010946:Plants, Medicinal / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C061097:breviscapine; D000432:Methanol