The nature of platinum in silicones for biomedical and healthcare use.
Silicone is an important biomaterial in many different biomedical and healthcare applications. Network formation in one type of silicone relies upon a chemical crosslinking reaction that typically employs a platinum catalyst. As a consequence, low concentrations of platinum may remain in certain medical devices designed for human use. The characteristics of platinum in silicone before, during, and after the crosslinking reaction have been well described in the literature. This review summarizes the relevant literature on the organometallic and analytical chemistry of platinum in silicone and thus provides a foundation for understanding the effects this platinum may have, if any, in the various biomedical and healthcare applications where it may be present.
Lambert
James M
JM
NuSil Technology, 800 East Leigh Street, Biotech Center, Suite 53, Richmond, Virginia 23219, USA. jiml@nusil.com
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D009757:Nylons; D010984:Platinum; D019736:Prostheses and Implants; D012828:Silicones
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D009757:Nylons; D012828:Silicones; C085707:poly(dimethylsiloxane)-polyamide copolymer; D010984:Platinum