The reactivity-selectivity principle: an imperishable myth in organic chemistry.
The reactivity-selectivity principle (RSP), once a tenet of organic chemistry, eroded during the 1970s and was more or less abandoned by 1980. Although it has been clear for more than 25 years that a decrease in selectivity with increasing reactivity can only be expected with certainty if diffusion control is approached, the RSP has survived as an intuitively appealing rule. This Minireview shows why selectivity cannot generally decrease with increasing reactivity and highlights the weaknesses of the theoretical foundations of the RSP.
Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Germany. herbert.mayr@cup.uni-muenchen.de
Herbert
H
Mayr
Armin R
AR
Ofial