A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines.
Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process.
School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, U.K.
Colin J
CJ
Dunsmore
Reuben
R
Carr
Toni
T
Fleming
Nicholas J
NJ
Turner
D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D001234:Aspergillus niger / Q000201:enzymology; D008995:Monoamine Oxidase / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism
D000588:Amines; D008995:Monoamine Oxidase