MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes.
The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs.
Miyake
Yoko
Y
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-ohsawa 1-1, Hachioji, Tokyo 192-0397 Japan.
Togashi
Humika
H
Tashiro
Mitsuru
M
Yamaguchi
Hiroshi
H
Oda
Shuji
S
Kudo
Megumi
M
Tanaka
Yoshiyuki
Y
Kondo
Yoshinori
Y
Sawa
Ryuichi
R
Fujimoto
Takashi
T
Machinami
Tomoya
T
Ono
Akira
A
D020029:Base Pairing; D002413:Cations, Divalent / Q000737:chemistry; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013941:Thymine / Q000737:chemistry*
D002413:Cations, Divalent; D004247:DNA; D008628:Mercury; D013941:Thymine