Low molecular weight indole fragments as IMPDH inhibitors.
The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.
Beevers
Rebekah E
RE
UCB Celltech, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
Buckley
George M
GM
Davies
Natasha
N
Fraser
Joanne L
JL
Galvin
Francis C
FC
Hannah
Duncan R
DR
Haughan
Alan F
AF
Jenkins
Kerry
K
Mack
Stephen R
SR
Pitt
William R
WR
Ratcliffe
Andrew J
AJ
Richard
Marianna D
MD
Sabin
Verity
V
Sharpe
Andrew
A
Williams
Sophie C
SC
D002219:Carbamates / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D010080:Oxazoles / Q000494:pharmacology; D010671:Phenylurea Compounds / Q000737:chemistry / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship
D002219:Carbamates; D004791:Enzyme Inhibitors; D007211:Indoles; C407002:N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester; D010080:Oxazoles; D010671:Phenylurea Compounds; D007168:IMP Dehydrogenase; C460179:BMS-337197