MicroRNAs in cell proliferation, cell death, and tumorigenesis.
MicroRNAs (miRNAs) are a recently discovered class of approximately 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.
Hwang
H-W
HW
Program in Human Genetics and Molecular Biology, The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 460C, Baltimore, MD 21205, USA.
Mendell
J T
JT
D016923:Cell Death; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D005786:Gene Expression Regulation; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs; D009369:Neoplasms / Q000503:physiopathology; D009857:Oncogenes
D035683:MicroRNAs