Atherosclerosis and the Lectin-like OXidized low-density lipoprotein scavenger receptor.
The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization. LOX-1 levels are elevated upon recognition of oxidized low-density lipoprotein, a key pro-atherogenic substance in the vasculature. Recent evidence indicates this gene product is a biomarker of inflammation and disease status. We review and assess the role of LOX-1 in atherosclerotic plaque formation, physiologic regulation, and as a biomarker and target in cardiovascular disease diagnosis and prevention.
Leeds Vascular Institute, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK.
Ravinder S
RS
Vohra
Jane E
JE
Murphy
John H
JH
Walker
Sreenivasan
S
Ponnambalam
Shervanthi
S
Homer-Vanniasinkam
D000818:Animals; D001158:Arteries / Q000473:pathology; D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D051127:Scavenger Receptors, Class E / Q000032:analysis / Q000378:metabolism*; D014158:Transcription, Genetic
D015415:Biomarkers; D051127:Scavenger Receptors, Class E