[Pure red cell aplasia following major ABO-incompatible allogeneic hematopoietic stem cell transplantation].
OBJECTIVE
To study clinical characteristics and outcome of pure red cell aplasia (PRCA) following major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT).


METHODS
Variables including sex, age, stem cell source, granulocyte engraftment time, blood transfusion and isoagglutinin type against donor RBC were analyzed to identify risk factors for the development of PRCA.


RESULTS
Twelve of 100 patients received major ABO-incompatible allo-HSCT developed PRCA, with out any effect on incidence of aGVHD and CMV infection. ABO blood groups of recipient/donor pairs of these twelve PRCA patients were O/A in nine, B/A in one and O/B in two. Patients with anti-A isoagglutinins against donor RBC developed PRCA more frequently than those with anti-B (10/49 vs 2/49). Median duration to the recovery of erythropoiesis tended to be longer in patients with PRCA (PRCA vs non-PRCA, 203.5 vs. 76 days, P < 0.05 ). Median durations to the disappearance of incompatible isoagglutinins tended to be longer in patients with PRCA (PRCA vs. non-PRCA, 150.5 vs. 60 days,P <0.05) and in those with anti-A isoagglutinins (anti-A vs anti-B, 90 vs 55 days, P < 0.05).


CONCLUSIONS
ABO blood group of O/A in recipient/donor pair was the only high risk factor for PRCA after major ABO-incompatible allo-HSCT.
Huang
Xiao-jun
XJ
People's Hospital, Peking University, Beijing, China.
Liu
Dai-hong
DH
Xu
Lan-ping
LP
Han
Wei
W
Jiang
Qian
Q
Chen
Yu-hong
YH
Zhang
Yao-chen
YC
Liu
Kai-yan
KY
Bao
Li
L
Lu
Dao-pei
DP
D000017:ABO Blood-Group System / Q000276:immunology; D001787:Blood Group Incompatibility; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors
D000017:ABO Blood-Group System