Splenic marginal zone lymphoma: a prognostic model for clinical use.
The Integruppo Italiano Linfomi (IIL) carried out a study to assess the outcomes of splenic marginal zone lymphoma and to identify prognostic factors in 309 patients. The 5-year cause-specific survival (CSS) rate was 76%. In univariate analysis, the parameters predictive of shorter CSS were hemoglobin levels below 12 g/dL (P < .001), albumin levels below 3.5 g/dL (P = .001), International Prognostic Index (IPI) scores of 2 to 3 (P < .001), lactate dehydrogenase (LDH) levels above normal (P < .001), age older than 60 years (P = .01), platelet counts below 100,000/microL (P = .04), HbsAg-positivity (P = .01), and no splenectomy at diagnosis (P = .006). Values that maintained a negative influence on CSS in multivariate analysis were hemoglobin level less than 12 g/dL, LDH level greater than normal, and albumin level less than 3.5 g/dL. Using these 3 variables, we grouped patients into 3 prognostic categories: low-risk group (41%) with no adverse factors, intermediate-risk group (34%) with one adverse factor, and high-risk group (25%) with 2 or 3 adverse factors. The 5-year CSS rate was 88% for the low-risk group, 73% for the intermediate-risk group, and 50% for the high-risk group. The cause-specific mortality rate (x 1000 person-years) was 20 for the low-risk group, 47 for the intermediate-risk group, and 174 for the high-risk group. This latter group accounted for 54% of all lymphoma-related deaths. In conclusion, with the use of readily available factors, this prognostic index may be an effective tool for evaluating the need for treatment and the intensity of therapy in an individual patient.
Arcaini
Luca
L
Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy. luca.arcaini@unipv.it
Lazzarino
Mario
M
Colombo
Nora
N
Burcheri
Sara
S
Boveri
Emanuela
E
Paulli
Marco
M
Morra
Enrica
E
Gambacorta
Marcello
M
Cortelazzo
Sergio
S
Tucci
Alessandra
A
Ungari
Marco
M
Ambrosetti
Achille
A
Menestrina
Fabio
F
Orsucci
Lorella
L
Novero
Domenico
D
Pulsoni
Alessandro
A
Frezzato
Maurizio
M
Gaidano
Gianluca
G
Vallisa
Daniele
D
Minardi
Viviana
V
Tripodo
Claudio
C
Callea
Vincenzo
V
Baldini
Luca
L
Merli
Francesco
F
Federico
Massimo
M
Franco
Vito
V
Iannitto
Emilio
E
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000032:analysis; D018572:Disease-Free Survival; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood; D008137:Longitudinal Studies; D016393:Lymphoma, B-Cell / Q000097:blood / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015999:Multivariate Analysis; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013160:Splenic Neoplasms / Q000097:blood / Q000401:mortality* / Q000628:therapy; D015996:Survival Rate
D000418:Albumins; D006454:Hemoglobins; D006836:Hydro-Lyases; C045581:lactate dehydratase