More TORC for the gluconeogenic engine.
Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the transcriptional regulator TORC2 (Transducer of Regulated CREB activity 2) as a pivotal component of the gluconeogenic program.1 Both insulin and AMPK increase the phosphorylation of TORC2, while glucagon suppresses it. This in turn regulates the nuclear/cytoplasmic shuttling of TORC2 and its ability to transactivate gluconeogenic genes. Thus, TORC2 might serve as a gluconeogenic "molecular switch" that senses hormones and cellular energy status.
Cheng
Alan
A
Department of Internal Medicine, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, 48109, USA.
Saltiel
Alan R
AR
D055372:AMP-Activated Protein Kinases; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D005934:Glucagon / Q000378:metabolism; D005943:Gluconeogenesis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D014157:Transcription Factors
C493245:CRTC2 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D007328:Insulin; D009097:Multienzyme Complexes; D010750:Phosphoproteins; D014157:Transcription Factors; D005934:Glucagon; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases