Intravenous lidocaine for status epilepticus during childhood.
The clinical efficacy of lidocaine for convulsive status epilepticus in 53 convulsive episodes was examined in 37 children (17 males, 20 females). Mean age of patients receiving lidocaine was 3 years 7 months (SD 3y 5mo). Lidocaine administration achieved control of status epilepticus in 19 of 53 convulsive episodes (35.8%). Seizures ceased within 5 minutes of lidocaine administration in all 19 patients who were responsive to the drug. Regarding aetiology of status epilepticus and types of seizures, there was no statistical difference in effectiveness. Mild decrease of oxygen saturation, monitored by pulse oximetry, was observed in one patient, which improved by oxygenation using a mask. Lidocaine is a useful anticonvulsive agent; however, the response rate to lidocaine appears to be quite low, as less than half of the seizures were effectively controlled by lidocaine. Favourable properties of the drug include prompt responses, less alteration of consciousness, and fewer adverse effects, including less respiratory depression.
Division of Neurology, Saitama Children's Medical Center, Japan. a1091170@pref.saitama.lg.jp
Shin-ichiro
S
Hamano
Nobuyoshi
N
Sugiyama
Shintaro
S
Yamashita
Manabu
M
Tanaka
Mika
M
Hayakawa
Motoyuki
M
Minamitani
Satoshi
S
Yoshinari
Yoshikatsu
Y
Eto
D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D010100:Oxygen / Q000378:metabolism; D012189:Retrospective Studies; D013226:Status Epilepticus / Q000188:drug therapy* / Q000378:metabolism
D000927:Anticonvulsants; D008012:Lidocaine; D008874:Midazolam; D010100:Oxygen