A highly enantioselective lewis basic organocatalyst for reduction of N-aryl imines with unprecedented substrate spectrum.
L-Pipecolinic acid derived formamides have been developed as highly efficient and enantioselective Lewis basic organocatalysts for the reduction of N-aryl imines with trichlorosilane. Catalyst 4b afforded high isolated yields (up to 98%) and enantioselectivities (up to 96%) under mild conditions with an unprecedented substrate spectrum.
Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
Zhouyu
Z
Wang
Xiaoxia
X
Ye
Siyu
S
Wei
Pengcheng
P
Wu
Anjiang
A
Zhang
Jian
J
Sun