Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole.
In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
Hua
H
Quan
Ying-Ying
YY
Cao
Zheng
Z
Xu
Jing-Xia
JX
Zhao
Ping-Hui
PH
Gao
Xiao-Feng
XF
Qin
Yuan-Ying
YY
Jiang
D000935:Antifungal Agents / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D025141:Drug Resistance, Fungal / Q000187:drug effects / Q000235:genetics*; D004357:Drug Synergism; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D001599:Berberine; D015725:Fluconazole