CDK activation by non-cyclin proteins.
Progression through the cell cycle is regulated by cyclin-dependent kinases (CDKs), which associate with activating partners, named cyclins, to phosphorylate substrates efficiently. Cyclins are periodically synthesized and degraded during the cell cycle, playing a key role in the precise activation and inactivation of CDKs. However, CDKs can also be activated by other proteins, which lack sequence similarity to cyclins. These include the RINGO/Speedy proteins, which were originally identified as regulators of the meiotic cell cycle in Xenopus oocytes. Recently, five different mammalian RINGO/Speedy family members have been reported, all of which can bind to and directly activate Cdk1 and Cdk2.
CNIO (Spanish National Cancer Center), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
Angel R
AR
Nebreda
D000818:Animals; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D051357:Cyclin-Dependent Kinase 2 / Q000235:genetics / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; D009419:Nerve Tissue Proteins; C486530:SPDYA protein, human; D029867:Xenopus Proteins; C119055:ls27 protein, Xenopus; C089495:neuronal Cdk5 activator (p25-p35); D016203:CDC2 Protein Kinase; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases