Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes.
Ihrie
R A
RA
Bronson
R T
RT
Attardi
L D
LD
D000375:Aging / Q000473:pathology; D000818:Animals; D004198:Disease Susceptibility; D004476:Ectodermal Dysplasia / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D006197:Hair / Q000002:abnormalities / Q000378:metabolism; D006579:Heterozygote; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D008565:Membrane Proteins; C406964:Perp protein, mouse; D010750:Phosphoproteins; D015534:Trans-Activators; C486419:Trp63 protein, mouse; D016159:Tumor Suppressor Protein p53