SARS-CoV infection in a restaurant from palm civet.
Epidemiologic investigations showed that 2 of 4 patients with severe acute respiratory syndrome (SARS) identified in the winter of 2003-2004 were a waitresss at a restaurant in Guangzhou, China, that served palm civets as food and a customer who ate in the restaurant ashort distance from animal cages. All 6 palm civets at the restaurant were positive for SARS-associated coronavirus (SARS-CoV). Partial spike (S) gene sequences of SARS-CoV from the 2 patients were identical to 4 of 5 Sgene viral sequences from palm civets. Phylogenetic analysis showed that SARS-CoV from palm civets in the restaurant was most closely related to animal isolates. SARS cases at the restaurant were the result of recent interspecies transfer from the putative palm civet reservoir, and not the result of continued circulation of SARS-CoV in the human population.
Wang
Ming
M
Guangzhou Municipal Center for Disease Control and Prevention, Guangdong, People's Republic of China.
Yan
Meiying
M
Xu
Huifang
H
Liang
Weili
W
Kan
Biao
B
Zheng
Bojian
B
Chen
Honglin
H
Zheng
Han
H
Xu
Yanmei
Y
Zhang
Enmin
E
Wang
Hongxia
H
Ye
Jingrong
J
Li
Guichang
G
Li
Machao
M
Cui
Zhigang
Z
Liu
Yu-Fei
YF
Guo
Rong-Tong
RT
Liu
Xiao-Ning
XN
Zhan
Liu-Hua
LH
Zhou
Duan-Hua
DH
Zhao
Ailan
A
Hai
Rong
R
Yu
Dongzhen
D
Guan
Yi
Y
Xu
Jianguo
J
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D005516:Food Microbiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D010802:Phylogeny; D012147:Restaurants; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics / Q000302:isolation & purification*; D045169:Severe Acute Respiratory Syndrome / Q000097:blood / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000235:genetics; D045949:Viverridae / Q000821:virology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins