C-terminal binding: an expanded repertoire and function of 14-3-3 proteins.
Amino and carboxyl termini are unique positions in a polypeptide. They tend to be exposed in folded three dimensional structures. Diversity and functional significance of C-terminal sequences have been appreciated from studies of PDZ and PEX domains. Signaling 14-3-3 protein signaling by recognizing phosphorylated peptides plays a critical role in a variety of biological processes, including oncogenesis. The preferential binding of 14-3-3 to phosphorylated C-terminal sequences, mode III, provides a means of regulated binding and considerably expands the substrate repertoire of 14-3-3 interaction partners.
Department of Neuroscience and High Throughput Biology Center, School of Medicine, Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, USA.
Brian
B
Coblitz
Meng
M
Wu
Sojin
S
Shikano
Min
M
Li
D048948:14-3-3 Proteins / Q000378:metabolism*; D020816:Amino Acid Motifs; D000818:Animals; D001665:Binding Sites; D016384:Consensus Sequence; D006801:Humans; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D048948:14-3-3 Proteins