The potential role of breast ductoscopy in breast cancer screening.
Breast cancer remains the most common malignancy among women in the Western world. Mammography, which is currently the main screening modality for early detection, has a low positive predictive value of only 25%, especially in young women with very dense breasts. Therefore, new screening approaches are needed for the early detection of breast cancer in all age groups. Mammary ductoscopy (MD) is a newly developed endoscopic technique that allows direct visualization and biopsy of the mammary ductal epithelium where most cancers originate. The procedure can be performed under local anesthesia in the office setting. At present, MD is used as a diagnostic adjunct in patients with pathological nipple discharge and to guide duct excision surgery. This article focuses on the potential of this technique in breast cancer screening and highlights its limitations in this context.
Department of Breast Surgery, St. George's Hospital, London, United Kingdom.
W Al
WA
Sarakbi
Pedro F
PF
Escobar
Kefah
K
Mokbel
D001943:Breast Neoplasms / Q000175:diagnosis*; D004724:Endoscopy / Q000379:methods*; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D042361:Mammary Glands, Human / Q000473:pathology*; D009558:Nipples / Q000473:pathology; D018570:Risk Assessment; D016387:Women's Health