Limited IL-6 production following infection with murine gammaherpesvirus 68.
Murine gammaherpesvirus 68 (gammaHV-68) was found to induce IL-6 secretion following in vitro infection of macrophages, but not cultured dendritic or epithelial cells. A detectable, but very limited IL-6 response was observed in the lungs and mediastinal lymph nodes following intranasal infection. Surprisingly, no detectable in vivo IL-6 production was observed in the spleen or sera of infected mice despite observable systemic leukocytosis. These studies demonstrate that endogenous IL-6 production contributes little to the host response, or to the viral-induced mononucleosis-like disease, due to the fact that limiting amounts of this cytokine are produced in vivo during gammaHV-68 infection.
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA.
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N
Gasper-Smith
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Singh
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KL
Bost
D000818:Animals; D002460:Cell Line; D003713:Dendritic Cells / Q000821:virology; D004195:Disease Models, Animal; D006566:Herpesviridae Infections / Q000276:immunology*; D015850:Interleukin-6 / Q000096:biosynthesis*; D007964:Leukocytosis; D008168:Lung / Q000737:chemistry; D008198:Lymph Nodes / Q000737:chemistry; D008264:Macrophages / Q000821:virology; D051379:Mice; D018144:Rhadinovirus / Q000276:immunology*; D013154:Spleen / Q000737:chemistry; D014412:Tumor Virus Infections / Q000276:immunology*
D015850:Interleukin-6