Influence of human B-casomorphin-7 on specific binding of 3H-spiperone to the 5-HT2-receptors of rat brain frontal cortex.
Using radio-receptor analysis, it has been demonstrated that human beta-casomorphin-7 (Tyr-Pro-Phe-Val-Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human beta-casomorphin-7 was 8 microM. These data suggest that one of the mechanisms of neurotropic action of beta-casomorphin-7 is might be associated with its influence on the serotoninergic system.
National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia. sokolov@rcmh.msk.ru
Oleg Yurievich
OY
Sokolov
Natalya Vsevolodovna
NV
Kost
Yurii Aleksandrovich
YA
Zolotarev
Ekaterina Nikolaevna
EN
Ryukert
Andrey Aleksandrovich
AA
Zozulya
D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*
D004723:Endorphins; D010446:Peptide Fragments; D044348:Receptors, Serotonin, 5-HT2; D013134:Spiperone; C041128:beta-casomorphin 7