QSAR models for Daphnia magna toxicity prediction of benzoxazinone allelochemicals and their transformation products.
The overall objective of this study is the ecotoxicological characterization of the benzoxazinone 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA), the benzoxazolinones benzoxazolin-2-one (BOA) and 6-methoxybenzoxazolin-2-one (MBOA), and their transformation products: phenoxazinones 2-acetylamino-7-methoxy-3H-phenoxazin-3-one (AAMPO), 2-acetylamino-3H-phenoxazin-3-one (AAPO), 2-amino-7-methoxy-3H-phenoxazin-3-one (AMPO), and 2-amino-3H-phenoxazin-3-one (APO); aminophenol 2-aminophenol AP); acetamide N-(2-hydroxyphenyl)acetamide (HPAA); and malonamic acid amide N-(2-hydroxyphenyl)malonamic acid (HPMA). A comparison between empirical results and theoretical ones using rules-based prediction of toxicity was done, and it can be concluded that only the degradation metabolites exhibited significant ecotoxic effect. Using synthetic pesticides knowledge, several QSAR models were trained with various approaches and descriptors. The models generated exhibited good internal predictive ability (R(cv)2 > 0.6) and were used to predict the toxicity of the natural compounds studied.
Lo Piparo
Elena
E
Istituto di Ricerche Farmacologiche "Mario Negri" Milano, Via Eritrea 62, 20157 Milano, Italy.
Fratev
Filip
F
Lemke
Frank
F
Mazzatorta
Paolo
P
Smiesko
Martin
M
Fritz
Jona Ines
JI
Benfenati
Emilio
E
D000818:Animals; D048588:Benzoxazines; D001583:Benzoxazoles / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D003621:Daphnia / Q000187:drug effects*; D010078:Oxazines / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D010675:Pheromones / Q000633:toxicity*; D021281:Quantitative Structure-Activity Relationship; D014908:Triticum / Q000737:chemistry
D048588:Benzoxazines; D001583:Benzoxazoles; D010078:Oxazines; D010675:Pheromones; C017057:benzoxazolone; C031896:6-methoxybenzoxazolinone; C050733:2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one