Looking for inspiration: new perspectives on respiratory rhythm.
Recent experiments in vivo and in vitro have advanced our understanding of the sites and mechanisms involved in mammalian respiratory rhythm generation. Here we evaluate and interpret the new evidence for two separate brainstem respiratory oscillators and for the essential role of emergent network properties in rhythm generation. Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing.
Feldman
Jack L
JL
Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, BOX 951763, Los Angeles, California 90095-1763, USA. feldman@ucla.edu
Del Negro
Christopher A
CA
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D012119:Respiration; D012125:Respiratory Center / Q000033:anatomy & histology / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System