Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study.
We report a rare case of giant vascular eccrine spiradenoma (GVES) which developed in 56-yr-old Korean woman. It is a rare variant of eccrine spiradenoma (ES), which might be mistaken for angiomatous lesions in view of its florid vascularity and hemorrhagic features. Histogenesis of GVES is not clearly elucidated although it is known that ES presumably originates in the eccrine glands. To clarify the histogenesis of GVES, immunohistochemical stainings using various monoclonal antibodies were also performed. The tumor was composed of three types of cells, namely pale epithelial cells, small basal cells, and myoepithelial cells. Therefore, we conclude that GVES originated from eccrine gland and mainly differentiates toward secretory portion of secretory coil.
Ko
Joo Youn
JY
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Lee
Chang Woo
CW
Moon
Sang Ho
SH
Song
Kang Won
KW
Park
Chan Kum
CK
D000199:Actins / Q000032:analysis; D006607:Adenoma, Sweat Gland / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D004439:Eccrine Glands / Q000098:blood supply / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D007723:Korea; D008565:Membrane Proteins / Q000032:analysis; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D009130:Muscle, Smooth / Q000737:chemistry; D013544:Sweat Gland Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*
D000199:Actins; D015415:Biomarkers; C400901:CAM 5.2 antigen; C081876:CKAP4 protein, human; C507497:KRT7 protein, human; D053552:Keratin-7; D008565:Membrane Proteins; D018396:Mucin-1; D007633:Keratins