Crosstalk between hepatocyte growth factor and integrin signaling pathways.
Most types of normal cells require integrin-mediated attachment to extracellular matrix to be able to respond to growth factor stimulation for proliferation and survival. Therefore, a consensus that integrins are close collaborators with growth factors in signal transduction has gradually emerged. Some integrins and growth factor receptors appear to be normally in relatively close proximity, which can be induced to form complexes upon cell adhesion or growth factor stimulation. Moreover, since integrins and growth factor receptors share many common elements in their signaling pathways, it is clear tzhat there are many opportunities for integrin signals to modulate growth factor signals and vice versa. Increasing evidence indicates that integrins can crosstalk with receptor tyrosine kinases in a cell- and integrin-type-dependent manner through a variety of specific mechanisms. This review is intended specifically for summarizing recent progress uncovering how the hepatocyte growth factor receptor c-Met coordinates with integrins to transmit signals.
Department of Life Sciences and Graduate Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo-Kuang road, Taichung, 40227, Taiwan.
Po-Chao
PC
Chan
Shu-Yi
SY
Chen
Chun-Hwa
CH
Chen
Hong-Chen
HC
Chen
D000818:Animals; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D020239:Receptor Cross-Talk / Q000502:physiology*; D015398:Signal Transduction
D016023:Integrins; D017228:Hepatocyte Growth Factor