Cutaneous sarcoidal granulomas developing after Artecoll facial cosmetic filler in a patient with newly diagnosed systemic sarcoidosis.
Artecoll is a recently developed permanent synthetic cosmetic filler substance, composed of 80% bovine collagen and 20% polymethylacrylate (PMMA) microspheres of 32-40 mum in diameter. It is used for the augmentation of deep wrinkles and is to be injected subdermally. We report the development of granulomas at the site of Artecoll injections in the face in a 48-year-old woman who had pulmonary sarcoidosis. There were features consistent of both sarcoid and foreign-body granuloma, typical of those reported previously with Artecoll. We postulate that the PMMA foreign material contained within Artecoll acted as a stimulus for the development of the cutaneous sarcoid granulomas.
Department of Respiratory Medicine, King Edward VII Hospital, London, UK.
R U
RU
Sidwell
N
N
McL Johnson
N
N
Francis
C B
CB
Bunker
D016587:Antimutagenic Agents / Q000009:adverse effects*; D003094:Collagen / Q000009:adverse effects; D003357:Cosmetic Techniques / Q000009:adverse effects; D004340:Drug Contamination; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D006099:Granuloma / Q000139:chemically induced*; D015745:Granuloma, Foreign-Body / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D019904:Polymethyl Methacrylate / Q000009:adverse effects*; D015361:Rhytidoplasty / Q000379:methods; D017565:Sarcoidosis, Pulmonary / Q000150:complications*; D012871:Skin Diseases / Q000139:chemically induced*
D016587:Antimutagenic Agents; C445359:Artecoll; D003094:Collagen; D019904:Polymethyl Methacrylate