Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate.
Chemoprevention is an attempt to use either naturally occurring or synthetic substances or their mixtures to intervene in the progress of carcinogenesis. Recently, it has been shown that some edible phytochemicals alter gene expression, directly or indirectly, thereby regulating the carcinogenic processes. (-)-Epigallocatechin gallate (EGCG), a principal antioxidant derived from green tea, is one of the most extensively investigated chemopreventive phytochemicals. EGCG has been known to block each stage of carcinogenesis by modulating signal transduction pathways involved in cell proliferation, transformation, inflammation, apoptosis, metastasis and invasion. This review addresses the molecular target-based chemoprevention with EGCG by focusing on the common events mediated by transcription factors, such as NF-kappa B, activator protein-1 and nuclear factor erythroid 2 p45-related factor, and upstream kinases involved in the cellular signaling network.
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea.
Hye-Kyung
HK
Na
Young-Joon
YJ
Surh
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D018890:Chemoprevention; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D050217:Metabolic Detoxication, Phase II; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009369:Neoplasms / Q000473:pathology; D011494:Protein Kinases / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects*; D013662:Tea / Q000737:chemistry*; D014157:Transcription Factors / Q000187:drug effects
D000975:Antioxidants; D013662:Tea; D014157:Transcription Factors; D002392:Catechin; C045651:epigallocatechin gallate; D011494:Protein Kinases