Signalling diacylglycerol pyrophosphate, a new phosphatidic acid metabolite.
Diacylglycerol pyrophosphate (DGPP) is a novel phospholipid that has been found in plants and yeast but not in higher animals. It is produced through phosphorylation of phosphatidic acid (PA) by the novel enzyme PA kinase (PAK). In plants, DGPP is virtually absent in non-stimulated cells but its concentration increases within minutes in response to various stimuli, including osmotic stress and pathogen attack, implying a role in stress signalling. DGPP is broken down by the enzyme DGPP phosphatase (DPP). DPP-encoding genes have been cloned from Arabidopsis thaliana and Saccharomyces cerevisiae (DPP1). In S. cerevisiae, the expression of DPP1 is regulated coordinately with the majority of genes encoding enzymes involved in phospholipid biosynthesis.
Section of Plant Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 318, 1098 SM Amsterdam, The Netherlands.
Bas
B
van Schooten
Christa
C
Testerink
Teun
T
Munnik
D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D011756:Diphosphates / Q000378:metabolism*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000378:metabolism; D008954:Models, Biological; D010712:Phosphatidic Acids / Q000378:metabolism; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000378:metabolism; D011755:Pyrophosphatases / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D011756:Diphosphates; D010712:Phosphatidic Acids; C408642:diacylglycerol pyrophosphate; D017856:Phosphotransferases (Phosphate Group Acceptor); C099834:phosphatidic acid kinase; D011755:Pyrophosphatases; C097892:diacylglycerol pyrophosphate phosphatase; D005990:Glycerol