Variability in the P6gag domains of HIV-1 involved in viral budding.
The genetic variability within PT/SAP, LYP and LXXLF HIV-1 P6gag motifs, required for the binding to Tsg101 and AIP1 cellular host proteins during viral budding, was examined in 122 HIV-infected subjects. PT/SAP duplications were statistically more frequent in B versus non-B subtypes. Substitutions at LYP were fourfold less frequent in antiretroviral-experienced only in clade B. P6gag variability across HIV-1 subtypes and after antiretroviral exposure may influence interactions with host cells involved in viral budding.
Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
Africa
A
Holguín
Amparo
A
Alvarez
Vincent
V
Soriano
D048868:Adaptor Proteins, Signal Transducing; D001665:Binding Sites; D002352:Carrier Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag / Q000235:genetics*; D014644:Genetic Variation; D051528:Guanylate Kinases; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D006801:Humans; D009154:Mutation / Q000235:genetics; D011506:Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014779:Virus Replication / Q000502:physiology; D000099177:Tsg101 Protein
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag; D051528:Guanylate Kinases; D011506:Proteins; D014157:Transcription Factors; D000099177:Tsg101 Protein; C485777:MAGI2 protein, human