Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts.
Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor alpha (ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio=1.44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63).
Shearman
Amanda M
AM
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. shearman@mit.edu
Cooper
Jackie A
JA
Kotwinski
Paul J
PJ
Miller
George J
GJ
Humphries
Steve E
SE
Ardlie
Kristin G
KG
Jordan
Barbara
B
Irenze
Kathryn
K
Lunetta
Kathryn L
KL
Schuit
Stephanie C E
SC
Uitterlinden
André G
AG
Pols
Huibert A P
HA
Demissie
Serkalem
S
Cupples
L Adrienne
LA
Mendelsohn
Michael E
ME
Levy
Daniel
D
Housman
David E
DE
D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology* / Q000235:genetics; D016017:Odds Ratio; D012307:Risk Factors
D047628:Estrogen Receptor alpha