[Pharmacodynamics of two different propofol formulations].
BACKGROUND
Propofol is nowadays available in various lipid formulations. We compared two different propofol formulations with respect to pharmacodynamics, using the EEG and clinical signs.


METHODS
Ten volunteers received Diprivan 1% and Propofol 1% MCT Fresenius as a computer controlled infusion with increasing propofol target concentrations. A sigmoid E(max) model with effect compartment was estimated for the median frequency of the EEG power spectrum, based on measured arterial propofol plasma concentrations. Clinical pharmacodynamics were assessed by reaction on acoustic stimuli, eyelid reflex and corneal reflex.


RESULTS
The drugs did not differ in pharmacodynamics with respect to EEG (EC(50) 2.1+/-0.6 for Diprivan and 2.1+/-0.5 microg/ml for Propofol Fresenius) and clinical signs. The pharmacodynamic model was characterized by a steep concentration effect relationship and a distinct hysteresis between propofol plasma concentration and effect (k(e0) 0.12+/-0.04 and 0.12+/-0.5 min(-1)).


CONCLUSIONS
The investigated lipid formulations have no influence on the pharmacodynamics of propofol.
Anästhesiologische Klinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstrasse 12, 91054 Erlangen. Harald.Ihmsen@kfa.imed.uni-erlangen.de
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Ihmsen
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Jeleazcov
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Schüttler
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Schwilden
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Bremer
D000161:Acoustic Stimulation; D000328:Adult; D000465:Algorithms; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001767:Blinking / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D004569:Electroencephalography / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D015233:Models, Statistical; D015742:Propofol / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D012018:Reflex / Q000187:drug effects
D018686:Anesthetics, Intravenous; D015742:Propofol