Effects of lidocaine and prednisolone on endoscopic rigid laryngoscopy.
OBJECTIVE
The aim of this study is to compare the effects of lidocaine and methylprednisolone on postoperative respiratory complications caused by short-term laryngeal surgery by way of rigid laryngoscope under general anesthesia. The effects of these drugs on recovery from anesthesia are also compared.


METHODS
One hundred American Society of Anesthesiologists physical status I to II patients over 20 years of age admitted for laryngeal mass, nodule, or polyp were included in this prospective, placebo-controlled, randomized, and double-blinded study.


METHODS
Patients were randomly allocated to four groups; methylprednisolone 3 mg.kg-1 (group 1), 0.9% saline physiologic 5 mL (group 2), lidocaine 1.5 mg.kg-1 (group 3) intravenously, seven puffs of lidocaine aerosol 10% to oropharyngolaryngeal structures topically (group 4) sprayed. Anesthesia recovery time was calculated. Respiratory system was evaluated using a scoring table during early postoperative period.


RESULTS
Ninety-two cases were suitable for analysis. Recovery time was longer in group 1 (9.8 3+/- 3.79 minutes) than in groups 3 and 4 (7.22 +/- 2.38, 7.50 +/- 2.30 minutes, respectively) (P < .05). Postoperative respiratory complications were lower in groups 3 and 4 than group 2 (P < .05).


CONCLUSIONS
Lidocaine intravenous or topical administration was effective in reducing postoperative respiratory complications after short-term laryngeal surgery by way of rigid laryngoscope. Methylprednisolone prolonged recovery time from anesthesia.
Kocamanoglu
Ismail Serhat
IS
Department of Anaesthesiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey. serhatk@omu.edu.tr
Sener
Elif Bengi
EB
Ustun
Emre
E
Tur
Ayla
A
D000280:Administration, Inhalation; D000762:Anesthesia Recovery Period; D000779:Anesthetics, Local; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007262:Infusions, Intravenous; D007442:Intubation, Intratracheal; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D020704:Laryngoscopes; D007828:Laryngoscopy / Q000009:adverse effects / Q000379:methods*; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000175:diagnosis; D011183:Postoperative Complications / Q000175:diagnosis* / Q000453:epidemiology; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment
D000779:Anesthetics, Local; D008012:Lidocaine; D008775:Methylprednisolone