Circadian variation of endothelial function in idiopathic dilated cardiomyopathy.
This study measured flow-mediated dilation (FMD) of the brachial artery 3 times a day (6:30 a.m., 11:30 a.m., and 9 p.m.) in 7 normal subjects and 14 patients with idiopathic dilated cardiomyopathy (7 in New York Heart Association [NYHA] functional class I or II and 7 in NYHA functional class III or IV). FMD in normal subjects and patients in NYHA class I or II showed a circadian variation, being lowest in the morning and highest at night. Compared with them, FMD in patients in NYHA class III or IV was lower and almost constant during the day, showing loss of significant circadian variation in endothelial function in patients with congestive heart failure.
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Okayama, Japan.
Takeshi
T
Maruo
Satoshi
S
Nakatani
Hideaki
H
Kanzaki
Hiroyuki
H
Kakuchi
Masakazu
M
Yamagishi
Masafumi
M
Kitakaze
Tohru
T
Ohe
Kunio
K
Miyatake
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000503:physiopathology; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000503:physiopathology*; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D005542:Forearm / Q000098:blood supply; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D005996:Nitroglycerin / Q000627:therapeutic use; D012039:Regional Blood Flow; D013318:Stroke Volume; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use
D015415:Biomarkers; D014665:Vasodilator Agents; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D005996:Nitroglycerin