Translocation (13;17)(q14;q25) as a novel chromosomal abnormality in acute myeloid leukemia-M4.
We report a case of AML-M4 in which G-band karyotyping revealed a previously unreported t(13;17)(q14;q25) in metaphase preparations. The breakpoints at 13q14 and 17q25 are associated with poor prognosis. The MSF and FKHR genes are located on 17q25 and 13q14, respectively. This report of AML-M4 harboring t(13;17)(q14;q25) as a unique cytogenetic abnormality provides more data on the leukomogenesis with rearrangements related with 13q14 and 17q25.
Turhan
Nihan
N
Ankara University, Faculty of Medicine, Medical Genetics Department, Ankara, Turkey. tukun@medicine.ankara.edu
Yürür-Kutlay
Nüket
N
Topcuoglu
Pervin
P
Sayki
Müyesser
M
Yüksel
Meltem
M
Gürman
Günhan
G
Tükün
Ajlan
A
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D020732:Cytogenetic Analysis / Q000379:methods; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012680:Sensitivity and Specificity; D014178:Translocation, Genetic / Q000235:genetics*