[Expression of deltaNp63 in salivary gland tumours].
OBJECTIVE
To detect the expression of deltaNp63 in human salivary gland tumor and analyze its role in the malignant salivary gland tumors.


METHODS
Collecting the samples from 68 cases of pathologically proven salivary gland tumours and investigating the microscopic sections with HE stain and immunohistochemical-SP stain.


RESULTS
It was found that the expression of deltaNp63 is gradually increased in the malignant tumours, the myoepithelial cells and the basal cells of the salivary gland tumors are positive, and the expression of deltaNp63 is correlated directly with benign and malignant tumor.


CONCLUSIONS
deltaNp63 plays an important role in salivary gland tumours. deltaNp63 possesses some special activity that is characteristic of oncogene. p63 is a sensitive and highly specific marker of myoepithelial cells in salivary gland tumours and an additional marker for defining myoepithelial histogenesis. p63 is of definite clinical value in falicitating diagnosis and differential diagnosis.
Department of Pathology, West China Stomatological Hospital, Sichuan University, Chengdu 610041, China.
Zhi-xiu
ZX
He
Yi-ning
YN
Li
Lai-kui
LK
Liu
Hua-wei
HW
He
Dan
D
Wang
D008949:Adenoma, Pleomorphic / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D003536:Cystadenocarcinoma / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D009208:Myoepithelioma / Q000378:metabolism* / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D015534:Trans-Activators / Q000096:biosynthesis*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins