Non-enzymatic regeneration of nicotinamide and flavin cofactors for monooxygenase catalysis.
Biocatalytic oxygenation chemistry is a rapidly evolving field in which monooxygenases are the tools of choice. Monooxygenases catalyze many industrially important synthetic transformations; however, their use in preparative applications is hampered by their intrinsic requirement for reducing equivalents. As a result, non-enzymatic strategies--where the reducing equivalents are introduced directly into the catalytic cycle--are being developed to supersede the well-established enzymatic NAD(P)H regeneration systems currently in use. In this review we summarize and evaluate recent achievements in this area.
Hollmann
F
F
Degussa Care & Surface Specialties, Goldschmidt AG, Goldschmidtstrasse 100, 45127 Essen, Germany.
Hofstetter
K
K
Schmid
A
A
D001665:Binding Sites; D002384:Catalysis; D005415:Flavins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009536:Niacinamide / Q000737:chemistry / Q000378:metabolism*
D005415:Flavins; D009536:Niacinamide; D006861:Hydrogen Peroxide; D006899:Mixed Function Oxygenases