Death from colonic disease in epidermolysis bullosa dystrophica.
BACKGROUND
Squamous cell carcinomas and renal failure were reported the causes of death in patients with recessive dystrophic epidermolysis bullosa (RDEB). Death from colonic disease in epidermolysis bullosa (EB) is never reported.


METHODS
We demonstrate a male patient with RDEB. He suffered megacolon due to fecal impaction and died from sigmoid colon perforation with peritonitis at age 35 years.


CONCLUSIONS
Constipation is a common clinical feature of RDEB, but fetal complications of chronic constipation are rarely reported. To the author's best knowledge, it has not been reported or recognized in the English literature previously. The aggressive assessment of constipation with fecal impaction is recommended in patients with RDEB.
Hsieh
Chih-Hsin
CH
Department of Orthopaedic Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, No,100, Tz-you 1st road, Kaohsiung 807, ROC, Taiwan. sid.h7746@msa.hinet.net
Huang
Che-Jen
CJ
Lin
Gau-Tyan
GT
D000328:Adult; D012809:Colon, Sigmoid; D016108:Epidermolysis Bullosa Dystrophica / Q000150:complications*; D017809:Fatal Outcome; D005244:Fecal Impaction / Q000150:complications*; D006801:Humans; D008297:Male; D012422:Rupture, Spontaneous; D012810:Sigmoid Diseases / Q000209:etiology* / Q000401:mortality