Involvement of potassium channels in hypoglycemic effect of sertraline.
Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10(-6)-10(-3) M) produced dose dependent relaxation (EC50-1.58 x 10(-5) M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglyceimic effects of sertraline.
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India. rkhanam@jamiahamdard.ac.in
Razia
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Khanam
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Pillai
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000032:analysis; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D009126:Muscle Relaxation / Q000187:drug effects*; D020110:Pinacidil / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D020280:Sertraline / Q000494:pharmacology* / Q000627:therapeutic use; D013311:Streptozocin; D013453:Sulfonylurea Compounds / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
D007004:Hypoglycemic Agents; D015221:Potassium Channels; D013453:Sulfonylurea Compounds; D014665:Vasodilator Agents; D013311:Streptozocin; C057619:glimepiride; D020110:Pinacidil; D005947:Glucose; D020280:Sertraline