Antimicrobial principle from Aframomum longifolius.
Antimicrobial activity-directed fractionation of the seeds of Aframomum longifolius (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12( E)-dien-16-al (aframolin A) ( 1) and 8beta(17)-epoxy-15,15-dimethoxylabd-12( E)-en-16-al (aframolin B) ( 2), together with the known diterpenes labda-8(17),12( E)-diene-15,16-dial ( 3) and aframodial ( 4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus (MRS) while 1, 2 and 3 were found to be inactive.
Tatsimo
Simplice Joel Ndendoung
SJ
Department of Organic Chemistry, University of Yaounde, Yaounde, Cameroon.
Tane
Pierre
P
Melissa
Jacob
J
Sondengam
Beibam L
BL
Okunji
Christopher O
CO
Schuster
Brian M
BM
Iwu
Maurice M
MM
Khan
Ikhlas A
IA
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016106:Methicillin Resistance; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D030521:Zingiberaceae / Q000737:chemistry*
D000890:Anti-Infective Agents; D004224:Diterpenes; D009281:Naphthalenes; D028321:Plant Preparations; D013141:Spiro Compounds; C081562:8,17-epoxylabd-12-ene-15,16-dial