[Bullous pemphigoid in an infant after vaccination].
Bullous pemphigoid (BP) is a disease that characteristically affects the elderly, although cases have been described in children. We present a case of BP in a two-month-old infant with bullous lesions on the palms and soles, which appeared one week after receiving the first dose of the hepatitis B, polio, DTP and HiB vaccine. She was treated with sulphated water, dexamethasone and fusidic acid, and the lesions disappeared. One month later, she presented with a new, more generalized outbreak, three days after the second dose of the same vaccine. The skin eruption completely subsided 3 months after treatment with deflazacort was initiated (1 mg/kg/day). After five years of follow up, the patient has not presented with lesions again, despite having received the rest of the vaccines on the official schedule.
Sección de Alergología, Hospital Universitario Virgen de la Arrixaca, Ctra. Madrid-Cartagena, 30120 El Palmar, Murcia, Spain. jmescribano@huva.es
Carolina
C
Mérida
Jorge A
JA
Martínez-Escribano
José F
JF
Frías
Paloma
P
Sánchez-Pedreño
Raúl
R
Corbalán
D004168:Diphtheria Toxoid / Q000009:adverse effects*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D005533:Foot Dermatoses / Q000209:etiology*; D018073:Haemophilus Vaccines / Q000009:adverse effects*; D006229:Hand Dermatoses / Q000209:etiology*; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D010391:Pemphigoid, Bullous / Q000209:etiology*; D010567:Pertussis Vaccine / Q000009:adverse effects*; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects*; D013745:Tetanus Toxoid / Q000009:adverse effects*; D017778:Vaccines, Combined / Q000009:adverse effects
C051021:DTPP vaccine; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D017325:Hepatitis B Vaccines; D010567:Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D013745:Tetanus Toxoid; D017778:Vaccines, Combined; C122182:diphtheria-tetanus-acellular pertussis-Hib-hepatitis B vaccine