PET modulated fluorescent sensing from the BF2 chelated azadipyrromethene platform.
A convergent building block synthesis has been applied to new off/on photoinduced electron transfer (PET) modulated fluorescent sensors which are based on a BF(2) chelated tetraarylazadipyrromethene platform and operate in the biomedically important red region of the visible spectrum. Incorporation of diethylamine and morpholine receptors facilitates off/on microenvironment polarity and pH sensing. Aqueous formulation and in vitro cellular imaging demonstrates their potential for intracellular sensing.
Hall
Michael J
MJ
Centre for Synthesis and Chemical Biology, Conway Institute, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Allen
Lorcan T
LT
O'Shea
Donal F
DF
D000475:Alkenes / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D001671:Biochemistry / Q000379:methods; D001896:Boron Compounds / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D003593:Cytoplasm / Q000378:metabolism; D004048:Diethylamines / Q000737:chemistry; D004579:Electron Transport; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009025:Morpholines / Q000737:chemistry; D010777:Photochemistry / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014269:Trifluoroacetic Acid / Q000737:chemistry
D000475:Alkenes; D001372:Aza Compounds; D001896:Boron Compounds; D002614:Chelating Agents; D004048:Diethylamines; D009025:Morpholines; C037574:morpholine; C034281:diethylamine; D014269:Trifluoroacetic Acid