Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease.
Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle.
Knizewski
Lukasz
L
Interdisciplinary Centre for Mathematical and Computational Modelling, Warsaw University, Poland.
Kinch
Lisa
L
Grishin
Nick V
NV
Rychlewski
Leszek
L
Ginalski
Krzysztof
K
D018138:Alphaherpesvirinae / Q000235:genetics; D000595:Amino Acid Sequence; D018141:Betaherpesvirinae / Q000235:genetics; D019295:Computational Biology; D004720:Endonucleases / Q000235:genetics* / Q000378:metabolism; D018142:Gammaherpesvirinae / Q000235:genetics; D018259:Herpesvirus 1, Human / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism*
C086267:UL24 protein, Human herpesvirus 1; D014764:Viral Proteins; D004720:Endonucleases