Parapoxviruses of seals and sea lions make up a distinct subclade within the genus Parapoxvirus.
Poxviruses of seals and sea lions have been tentatively identified as both orthopoxviruses and parapoxviruses, but their exact identity remained unconfirmed. Here, poxviral DNA sequences were generated from 39 clinical cases and compared to sequences from earlier poxvirus isolates from seals (Phocidae) and sea lions (Otariidae). Six genetically distinct poxvirus strains were detected, of which three were previously unrecognized. All detected strains were closely related to the parapoxviruses, confirming their classification as members of the genus Parapoxvirus. A phylogenetic analysis showed that pinniped parapoxviruses form a monophyletic group within the genus Parapoxvirus. Parapoxviruses from Atlantic pinnipeds were phylogenetically distant from those of Pacific pinnipeds. Parapoxviruses from phocids and otariids that inhabit the same geographical region were also phylogenetically distant, suggesting that parapoxviruses are not commonly transmitted between free-ranging phocids and otariids. However, one strain was detected in two otariid species, suggesting that pinniped parapoxviruses are capable of infecting multiple species within a phylogenetic family.
Nollens
Hendrik H
HH
Marine Mammal Health Program and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, FL 32610, USA. NollensH@mail.vetmed.ufl.edu
Gulland
Frances M D
FM
Jacobson
Elliott R
ER
Hernandez
Jorge A
JA
Klein
Paul A
PA
Walsh
Michael T
MT
Condit
Richard C
RC
D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D014644:Genetic Variation; D016679:Genome, Viral; D008969:Molecular Sequence Data; D018157:Parapoxvirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D010802:Phylogeny; D011213:Poxviridae Infections / Q000662:veterinary* / Q000821:virology; D046070:Sea Lions / Q000821:virology*; D046048:Seals, Earless / Q000821:virology*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
D004279:DNA, Viral