Drug Targets for Plasmodium falciparum: a post-genomic review/survey.
Over 300 million cases of malaria each year cause significant morbidity and mortality. Growing drug-resistance among the Plasmodia that cause malaria motivates the development of additional anti-malarial drugs. This review summarizes the current state of knowledge about potential drug targets for malaria. The recently sequenced malaria genome data clarifies parasite metabolic pathways, and more metabolic targets have been identified.
Department of Genetics, Stanford University, California, USA.
Iwei
I
Yeh
Russ B
RB
Altman
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D004261:DNA Replication; D004351:Drug Resistance; D018503:Genome, Protozoan; D050356:Lipid Metabolism; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D000962:Antimalarials