Influence of stearic acid on hemostatic risk factors in humans.
Stearic acid has been claimed to be prothrombotic. Elevated plasma factor VII coagulant activity (FVIIc) may raise the risk of coronary thrombosis in the event of plaque rupture. Fibrinogen, an acute-phase protein, is necessary for normal blood clotting; however, elevated levels of fibrinogen increase the risk of coronary heart disease (CHD). Here I report the results of three controlled, human dietary intervention studies, which used a randomized crossover design to investigate the hemostatic effects of stearic acid-rich test diets in healthy young men. A diet high in stearic acid (shea butter) resulted in a 13% lower fasting plasma FVIIc than a high palmitic acid diet, and was 18% lower than a diet high in myristic and lauric acids (P = 0.001) after 3 wk of intervention. The stearic acid-rich test fat increased plasma fibrinogen concentrations slightly compared with the myristic-lauric acid diet (P < 0.01). When investigating the acute effects of fatty meals, those high in stearic acid (synthesized test fat) resulted in a smaller postprandial increase in FVII than those high in trans and oleic FA, indicating a smaller increase in activated FVII after ingesting stearic acid compared with fats high in monounsaturated FA, probably caused by lower postprandial lipemia. Thus, the present investigations did not find dietary stearic acid to be more thrombogenic, in either fasting effects compared with other long-chain FA, or in acute effects compared with dietary unsaturated FA, including trans monounsaturated FA. The slightly increased effect on fasting plasma fibrinogen may be biologically insignificant, but it should be investigated further.
Tholstrup
Tine
T
The Research Department of Human Nutrition, Centre of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. tth@kvl.dk
D000328:Adult; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology*; D004435:Eating; D005167:Factor VII / Q000378:metabolism; D005215:Fasting / Q000097:blood; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D012307:Risk Factors; D013229:Stearic Acids / Q000009:adverse effects / Q000494:pharmacology*; D013927:Thrombosis / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000097:blood; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D017395:Plasminogen Activator Inhibitor 1; D013229:Stearic Acids; D014280:Triglycerides; C031183:stearic acid; D005167:Factor VII; D010959:Tissue Plasminogen Activator