[Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln[ (Phen)2 (5-Fu)3 (NO3) (NO3 )2].
OBJECTIVE
To study the biochemistry of lanthanides, the cooperative action of inorganic and organic anti-tumor drugs.


METHODS
A series of rare earth complexes were synthesized with Ln(NO3) 6H2O, Phen and 5-Fu. Their anti-tumor activity was measured by the improved MTT, SRB methods.


RESULTS
The formula of complex Ln[(Phen)2(5-Fu)3(NO3)](NO3)2(Ln = Y, La, Ce, Sm, Gd, Dy, Er; Phen = 1, 10-phenanthroline; 5-Fu = fluorouracil) was characterized by elemental analyses, molar conductivity, IR, TGA, and 13C NMR spectra. The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro.


CONCLUSIONS
The complex might have anti-tumor cooperation action.
Kunming Teachers College, Kunming 650031, China.
Wen-yuan
WY
Zhong
Zhi-xing
ZX
Hu
Shun-fang
SF
Chen
Shu-yu
SY
Ji
Yi-ping
YP
Zhou
Ma-lin
ML
Li
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002563:Cerium / Q000737:chemistry; D004357:Drug Synergism; D004419:Dysprosium / Q000737:chemistry; D004871:Erbium / Q000737:chemistry; D005472:Fluorouracil / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D007811:Lanthanum / Q000737:chemistry; D010618:Phenanthrolines / Q000737:chemistry; D012493:Samarium / Q000737:chemistry; D013329:Structure-Activity Relationship; D015019:Yttrium / Q000737:chemistry
D000970:Antineoplastic Agents; D028581:Lanthanoid Series Elements; D010618:Phenanthrolines; D004419:Dysprosium; D002563:Cerium; D012493:Samarium; D015019:Yttrium; D007811:Lanthanum; D004871:Erbium; D005682:Gadolinium; D005472:Fluorouracil