No Spt6, no nucleosomes, no activator required.
In the February 3 issue of Molecular Cell, a paper from Adkins and Tyler (2006) demonstrates that nucleosome reassembly is required for gene repression and, strikingly, that transcriptional activators are not necessary for gene activation in the absence of nucleosome reassembly.
Davie
Judith K
JK
Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Dent
Sharon Y R
SY
D000135:Acid Phosphatase; D002843:Chromatin / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D056488:Histone Chaperones; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation; D035602:Transcriptional Elongation Factors
D002843:Chromatin; D056488:Histone Chaperones; D009687:Nuclear Proteins; D009707:Nucleosomes; C065456:SPT6 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D035602:Transcriptional Elongation Factors; D000135:Acid Phosphatase; C488916:PHO5 protein, S cerevisiae