Low molecular weight indole fragments as IMPDH inhibitors.
The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.
UCB Celltech, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
Rebekah E
RE
Beevers
George M
GM
Buckley
Natasha
N
Davies
Joanne L
JL
Fraser
Francis C
FC
Galvin
Duncan R
DR
Hannah
Alan F
AF
Haughan
Kerry
K
Jenkins
Stephen R
SR
Mack
William R
WR
Pitt
Andrew J
AJ
Ratcliffe
Marianna D
MD
Richard
Verity
V
Sabin
Andrew
A
Sharpe
Sophie C
SC
Williams
D002219:Carbamates / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D010080:Oxazoles / Q000494:pharmacology; D010671:Phenylurea Compounds / Q000737:chemistry / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship
D002219:Carbamates; D004791:Enzyme Inhibitors; D007211:Indoles; C407002:N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester; D010080:Oxazoles; D010671:Phenylurea Compounds; D007168:IMP Dehydrogenase; C460179:BMS-337197