Necrotizing leukoencephalopathy associated with nonconvulsive status epilepticus and periodic short-interval diffuse discharges: a clinicopathological study.
We describe the clinical, neuroimaging and neuropathological features of an immunocompromised patient diagnosed as having refractory nonconvulsive status epilepticus (NCSE), and whose consecutive electroencephalograms (EEGs) revealed persistent periodic short-interval diffuse discharges (PSIDDs). Prominent subcortical white matter lesions in keeping with the diagnosis of multifocal necrotizing leukoencephalopathy may be neuropathological substrate of NCSE with persistent PSIDDs.
Fernández-Torre
J L
JL
Department of Clinical Neurophysiology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain. jlfernandez@humv.es
Arce
F
F
Martínez-Martínez
M
M
González-Rato
J
J
Infante
J
J
Calleja
J
J
D001921:Brain / Q000473:pathology*; D004569:Electroencephalography; D017809:Fatal Outcome; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010507:Periodicity; D013226:Status Epilepticus / Q000150:complications* / Q000175:diagnosis*