[Efficacy and tolerance of antiretroviral therapy in HIV-2 infected patients in Dakar: preliminary study].
OBJECTIVE
The authors had for aim to evaluate the clinical and immunological response as well as the tolerance to antiretroviral therapy in HIV-2 infected patients.


METHODS
A retrospective chart review was made from August 1998 to August 2004.


RESULTS
188 patients were on protease inhibitor based regimen. 153 (81.38%) were HIV-1 and 35 (18.62%) HIV-2 infected patients. The mean weight gain was significantly higher in the HIV-2 group at months 9 and 12 (P=0.02 et P=0.01 respectively), whereas CD4 cells count gain was higher in the HIV-1 group at month 6 (P=0.004). New AIDS defining criteria are less likely to occur in HIV-2 infected patients on HAART than in HIV-1 (P=0.004). Lipodystrophy syndrome was present only in HIV-1 infected patients.


CONCLUSIONS
Antiretroviral therapy in HIV-2 infected patients shows similar clinical and immunological efficacy than in HIV-1 infected ones and is also well tolerated.
Clinique des maladies infectieuses Ibrahima-Diop-Mar, CHU de Fann, BP 5035, avenue Cheikh-Anta-Diop, Dakar, Sénégal. elhaji3@yahoo.com
C T
CT
Ndour
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G
Batista
N M
NM
Manga
N F Ngom
NF
Guèye
N M Dia
NM
Badiane
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Fortez
P S
PS
Sow
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects / Q000302:isolation & purification; D015498:HIV-2 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D012189:Retrospective Studies; D012675:Senegal; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors