Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation.
In clinical 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) of skin tumors it is desirable to develop vehicles that minimize the penetration of ALA through normal stratum corneum and maximize it through the compromised stratum corneum of the tumors to improve tumor selectivity. We have designed a bioadhesive patch, which may be able to achieve this aim. It induces levels of protoporphyrin IX (PpIX) in skin overlying tumors similar to those induced by the proprietary cream (Porphin) but at the same time induces less PpIX to form in normal skin and at distant sites. The mechanisms of action of the patch, as compared with that of the cream, were studied by means of Cuprophan barriers that mimic compromised tumor stratum corneum and in a mouse model with transplanted tumors.
School of Pharmacy, Queen's University Belfast, Medical Biology Centre, UK. r.donnelly@qub.ac.uk
Ryan F
RF
Donnelly
Li-Wei
LW
Ma
Petras
P
Juzenas
Vladimir
V
Iani
Paul A
PA
McCarron
A David
AD
Woolfson
Johan
J
Moan
D000279:Administration, Cutaneous; D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D009369:Neoplasms / Q000628:therapy; D011524:Protoporphyrins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012869:Skin Absorption
D011524:Protoporphyrins; C028025:protoporphyrin IX