TLR2 is necessary to inflammatory response in Coxiella burnetii infection.
The resolution of Q fever, a zoonosis caused by Coxiella burnetii, depends on efficient innate and adaptive immune responses. Such responses are influenced by Toll-like receptors (TLRs). TLR4 is involved only in part in immune responses against C. burnetii, suggesting a role for TLR2. We investigated C. burnetii infection in wild-type and TLR2(-/-) mice. C. burnetii organisms were similarly eliminated by wild-type and TLR2(-/-) mice. In contrast, the formation of granulomas, a marker for efficient cell-mediated immunity, was markedly impaired. These results show that TLR2 is required for inflammatory and immune response to C. burnetii, but is dispensable for bacterial clearance.
Meghari
Soraya
S
Unité des Rickerrsies, CNRS UMR 6020, Université de Méditerranée, 13005 Marseille, France.
Honstettre
Amélie
A
Lepidi
Hubert
H
Ryffel
Bernardt
B
Raoult
Didier
D
Mege
Jean-Louis
JL
D000818:Animals; D016997:Coxiella burnetii / Q000276:immunology*; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000382:microbiology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology*; D008099:Liver / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011778:Q Fever / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D013154:Spleen / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D018836:Inflammation Mediators; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2