A diagnostic pitfall: nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis mimicking a sclerosing mucoepidermoid carcinoma with eosinophilia.
Nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis is an exceptional, benign condition presenting diagnostic difficulties for the pathologist. The main differential diagnosis is a sclerosing mucoepidermoid carcinoma (SMC) with eosinophilia. One case arising in a 50-year-old Caucasian man is reported. Histologically, the nodule consisted of large nests of squamous cells surrounded by connective tissue in Hashimoto's thyroiditis. We present the different histological criteria, allowing us to eliminate an SMC and other neoplastic tumors of the thyroid. The etiology of this tumor-like lesion, which is still under debate, is discussed.
Musso-Lassalle
Sandra
S
Laboratory of Clinical and Experimental Pathology, 30 avenue de la voie romaine, Louis Pasteur Hospital, 06002 Nice, France.
Butori
Catherine
C
Bailleux
Sonenda
S
Santini
José
J
Franc
Brigitte
B
Hofman
Paul
P
D018277:Carcinoma, Mucoepidermoid / Q000150:complications / Q000473:pathology*; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications / Q000473:pathology*; D050031:Hashimoto Disease / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000150:complications / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology*