Aggregation-induced folding of a de novo designed polypeptide immobilized on gold nanoparticles.
This communication reports the first steps in the construction of a novel, nanoparticle-based hybrid material for biomimetic and biosensor applications. Gold nanoparticles were modified with synthetic polypeptides to enable control of the particle aggregation state in a switchable manner, and particle aggregation was, in turn, found to induce folding of the immobilized peptides.
Department of Physics, Chemistry and Biology, IFM, Linköping University, SE-581 83 Linköping, Sweden.
Daniel
D
Aili
Karin
K
Enander
Johan
J
Rydberg
Ingemar
I
Lundström
Lars
L
Baltzer
Bo
B
Liedberg
D000595:Amino Acid Sequence; D019281:Dimerization; D018698:Glutamic Acid / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding
D010455:Peptides; D018698:Glutamic Acid; D006046:Gold