50 Hz magnetic fields of 1 mT do not promote lymphoma development in AKR/J mice.
Some epidemiological studies suggest that exposure to power-frequency magnetic fields increases the risk of leukemia, especially in children with high residential exposures. In contrast, most animal studies did not find a correlation between magnetic-field exposure and hematopoietic diseases. The present study was performed to investigate whether chronic, high-level (1 mT) magnetic-field exposure had an influence on lymphoma development in a mouse strain that is genetically predisposed to thymic lymphoblastic lymphoma. Three groups of 160 unrestrained female AKR/J mice were sham-exposed or exposed to sinusoidal 50 Hz magnetic fields beginning at the age of 12 weeks for 32 weeks, 7 days per week, either for 24 h per day or only during nighttime (12 h). Exposure was carried out in a blind design. Exposure did not affect survival time, body weight, lymphoma development or hematological parameters. The resulting data do not support the hypothesis that exposure to sinusoidal 50 Hz magnetic fields is a significant risk factor for hematopoietic diseases, even at this relatively high exposure level.
School of Engineering and Science, International University Bremen, Bremen, Germany.
Angela M
AM
Sommer
Alexander
A
Lerchl
D000818:Animals; D001835:Body Weight; D005260:Female; D008223:Lymphoma / Q000209:etiology* / Q000473:pathology* / Q000517:prevention & control; D008280:Magnetics; D051379:Mice; D008806:Mice, Inbred AKR; D009929:Organ Size; D013154:Spleen / Q000473:pathology; D015996:Survival Rate; D013950:Thymus Gland / Q000473:pathology