NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus.
NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.
Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston Massachusetts 02114-2696, USA.
Que Chi
QC
Truong-Bolduc
Jacob
J
Strahilevitz
David C
DC
Hooper
D000900:Anti-Bacterial Agents / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001693:Biological Transport, Active; D003001:Cloning, Molecular; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005809:Genes, Regulator; D008826:Microbial Sensitivity Tests; D009154:Mutation; D015363:Quinolones / Q000378:metabolism; D012329:RNA, Bacterial / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013211:Staphylococcus aureus / Q000235:genetics / Q000502:physiology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015363:Quinolones; D012329:RNA, Bacterial; D012333:RNA, Messenger; D012097:Repressor Proteins