Method development for the determination of residual fluorotelomer raw materials and perflurooctanoate in fluorotelomer-based products by gas chromatography and liquid chromatography mass spectrometry.
The methodology for the determination of perfluorooctanoate (C(7)F(15)COO-, PFO), fluorotelomer alcohols (FTOHs: 6-2, 8-2, and 10-2), perfluorooctyl iodide (PFOI), and 8-2-8 fluorotelomer alcohol ester in complex fluorotelomer-based commercial products has been demonstrated and validated. Sample preparation procedures allowing determination of residual levels of these compounds were developed. The analytes were detected either by LC/MS/MS (PFO), LC/MS (FTOHs), or GC/MS (PFOI, 8-2-8 ester). The methods were validated by investigating the recoveries of analytes spiked at multiple levels to authentic sample matrices. The recoveries generally were between 70 and 130%. The limits of detection were in sub-microg/g range and the limits of quantitation were in the mug/g range. The methods were applied to fluorotelomer-based raw materials and fluorotelomer-based surfactants and polymeric products and represent methods useful for the determination of higher carbon chain length homologs as well.
Larsen
Barbara S
BS
DuPont Corporate Center for Analytical Sciences, Central Research and Development, Experimental Station, Wilmington, DE 19880, USA. barbara.s.larsen@usa.dupont.com
Stchur
Peter
P
Szostek
Bogdan
B
Bachmura
Stanley F
SF
Rowand
Raymond C
RC
Prickett
Keith B
KB
Korzeniowski
Stephen H
SH
Buck
Robert C
RC
D000438:Alcohols / Q000032:analysis; D002210:Caprylates / Q000032:analysis*; D002244:Carbon / Q000737:chemistry; D002849:Chromatography, Gas / Q000379:methods*; D004952:Esters / Q000032:analysis; D005233:Fatty Alcohols / Q000032:analysis; D005466:Fluorocarbons / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006847:Hydrocarbons, Iodinated / Q000032:analysis; D011108:Polymers / Q000032:analysis*; D013501:Surface-Active Agents / Q000032:analysis*
C505284:1,1,2,2-tetrahydroheptadecafluorodecanol-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol; D000438:Alcohols; D002210:Caprylates; D004952:Esters; D005233:Fatty Alcohols; D005466:Fluorocarbons; D006847:Hydrocarbons, Iodinated; D011108:Polymers; D013501:Surface-Active Agents; D002244:Carbon; C023036:perfluorooctanoic acid