Stereoselective synthesis of beta-substituted beta-amino sulfones and sulfonamides via addition of sulfonyl anions to chiral N-sulfinyl imines.
[reaction: see text] A highly stereoselective synthesis of beta-amino sulfones and sulfonamides via addition of sulfonyl anions to chiral N-sulfinyl imines is described. The addition reaction proceeds in good yield (75-99%) and stereoselectivity.
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033-1300, USA. francisco.velazquez@spcorp.com
Francisco
F
Velázquez
Ashok
A
Arasappan
Kevin
K
Chen
Mousumi
M
Sannigrahi
Srikanth
S
Venkatraman
Andrew T
AT
McPhail
Tze-Ming
TM
Chan
Neng-Yang
NY
Shih
F George
FG
Njoroge