Evaluation of the clinical behaviour of a polyvinylpyrrolidone and sodium hyalonurate gel (Gelclair) in patients subjected to surgical treatment with CO2 laser.
This experimental study was undertaken to evaluate the efficacy of Gelclair, a concentrated oral gel consisting of sodium hyalonurate and polyvinylpyrrolidone, in decreasing postoperative pain in patients subjected to surgical treatment by extirpation and/or vapourization of oral lesions with CO(2) laser. After the surgery, 60 consecutive patients (30 in control group and 30 in experimental group) were prescribed 600 mg ibuprofen 3 times per day for 4 days. In the experimental group a protocol was established for the application of 15 ml of Gelclair directly onto the wound 3 times per day, 1 h before meals, for 1 week. Spontaneous pain and pain on swallowing were evaluated using a visual analogue scale at 24 h and 7 days after the intervention. The experimental group had less spontaneous pain at 24h (P=0.000) and at 1 week (P=0.012), and also less pain on swallowing at 24 h and 1 week (P=0.029 and P=0.000, respectively) after the intervention. In conclusion, the effectiveness of the barrier mechanism that Gelclair provides improves the postoperative experience of patients who have undergone oral CO(2) laser surgery.
Hita-Iglesias
P
P
Department of Oral Surgery, Faculty of Dentistry, University of Seville, C/ Avicena s/n 41009, Seville, Spain.
Torres-Lagares
D
D
Gutiérrez-Pérez
J L
JL
D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D002245:Carbon Dioxide; D003679:Deglutition / Q000502:physiology; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000601:surgery*; D009062:Mouth Neoplasms / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011205:Povidone / Q000008:administration & dosage / Q000627:therapeutic use*
D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; C439265:Gelclair; D005782:Gels; D002245:Carbon Dioxide; D006820:Hyaluronic Acid; D011205:Povidone; D007052:Ibuprofen