Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA.
Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.
Puerta
David T
DT
Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA 92093, USA.
Botta
Mauro
M
Jocher
Christoph J
CJ
Werner
Eric J
EJ
Avedano
Stefano
S
Raymond
Kenneth N
KN
Cohen
Seth M
SM
D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011753:Pyrones / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility
D002614:Chelating Agents; D003287:Contrast Media; D005029:Ethylenediamines; D011753:Pyrones; C099539:tris(2-aminoethyl)amine; D005682:Gadolinium