[Childhood infection and endothelial dysfunction: a potential synergistic link in atherosclerosis].
The prodromal stage of atherosclerotic lesions is already formed during human fetal development. The presence of infections during childhood may increase synergistically the progression of atherogenesis. After delivery, especially those children exposed to severe maternal hypercholesterolemia should be followed up for the onset and development of acute and chronic infections and be included in clinical and noninvasive examinations of vascular function.
Napoli
Claudio
C
Centro di Eccellenza nella Ricerca sulle Malattie Cardiovascolari e Cattedra di Patologia Clinica, Dipartimento di Patologia Generale, II Università di Napoli. claunap@tin.it
Pignalosa
Orlando
O
Gallo
Lidia
L
Graziano
Gabriella
G
Carotenuto
Filomena
F
Fiorito
Carmela
C
Mita
Luigi
L
Botti
Chiara
C
de Nigris
Filomena
F
Sica
Vincenzo
V
D050197:Atherosclerosis / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D047109:Fetal Development; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D007239:Infections / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012307:Risk Factors