[Protective effect on the corneal endothelium and remaining effect at the anterior chamber for three different kinds of viscoelastic devices].
OBJECTIVE
The present study was performed to evaluate the corneal endothelium protection and anterior chamber stagnation abilities of three different types of viscoelastic substances (Healon, Viscoat, HealonV).


METHODS
Viscoelastic substances were selected at random for 120 eyes with cataracts, and the postoperative reduction rates of the corneal endothelium cells were compared. The residual viscoelastic substances after filling of the anterior chamber of pig eyes and aspiration with a handpiece were measured by an anterior eye segment image analysis system. The same procedures were performed in rabbit eyes and the residual levels of viscoelastic substances on the corneal endothelium were photographed histologically.


RESULTS
The reduction rate of endothelium corneal cells tended to decrease with Viscoat three months after surgery. The results obtained with the anterior eye segment image analysis system showed that the residual level in the anterior chamber was higher with Healon. Histological analyses demonstrated residual Viscoat at the center of the corneal endothelium after perfusion.


CONCLUSIONS
HealonV was superior in terms of spatial retention and Viscoat had corneal endothelium protection potential.
Department of Opthalmology, Dokkyo University School of Medicine, Tochigi, Japan. mi-eda@dokkyomed.ac.jp
Minako
M
Eda
Hiroyuki
H
Matsushima
Wataru
W
Terauchi
Koichiro
K
Mukai
Shinsaku
S
Izumida
Yoshitaka
Y
Obara
Shinichiro
S
Yoshida
Shunsuke
S
Takeshima
D000368:Aged; D000818:Animals; D000867:Anterior Chamber; D002807:Chondroitin / Q000032:analysis* / Q000494:pharmacology*; D002809:Chondroitin Sulfates; D004338:Drug Combinations; D004548:Elasticity; D004728:Endothelium, Corneal / Q000737:chemistry / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis* / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D014783:Viscosity
D004338:Drug Combinations; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates