[A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old].
OBJECTIVE
To better understand and measure the impact from immunization activities over the last 10-years, we conducted a sero-epidemiological study using the remaining blood samples of a nationwide survey on Nutrition and Health in Chinese residents, in 2002.


METHODS
HBsAg, anti-HBs and anti-HBc in blood samples were tested using enzyme-linked immunosorbent assay(ELISA) reagents and revised by solid phase radioimmunoassay and Abbott ELISA reagents.


RESULTS
Among population older than 3 years, the prevalence rates of HBsAg, anti-HBs and hepatitis B virus(HBV) infection were 9.09%, 37.48% and 50.04% but for children between 3 and 12 year olds, they were 5.03%, 45.33% and 29.10% respectively. Among population older than 3 years, the rates of HBsAg and HBV infection in urban area were 4.61% and 43.51%, but the rates in rural area were 9.41% and 56.77% respectively while for children from 3-years to 12-years old, they rates were 2.10%, 20.45% in urban area and 8.25%, 39.22% in rural areas, respectively.


CONCLUSIONS
Results revealed that since the hepatitis B vaccine was introduced into the expanded program on immunization(EPI) from 1992, the prevalence rates of HBsAg and HBV infection, especially in the children from 3 to 12 years of age, had obviously declined, suggesting that some changes had happened in the epidemic characters of hepatitis B in China.
Liang
Xiao-feng
XF
Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Chen
Yuan-sheng
YS
Wang
Xiao-jun
XJ
He
Xiong
X
Chen
Li-juan
LJ
Wang
Jun
J
Lin
Chang-ying
CY
Bai
Hu-qun
HQ
Yan
Jun
J
Cui
Gang
G
Yu
Jing-jin
JJ
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D014761:Viral Hepatitis Vaccines / Q000276:immunology; D055815:Young Adult
D014761:Viral Hepatitis Vaccines