Dioxiranes generated in situ from pyruvates and oxone as environmentally friendly oxidizing agents for disinfection.
Dioxiranes generated in situ from pyruvates (alpha-keto esters) and Oxone have been found to be environmentally friendly oxidizing agents for disinfection. These oxidizing agents were highly effective for destruction of various strains of bacteria, fungi, and bacterial endospores in a wide temperature range with exceptional stability. Notably, by using an aqueous solution of methyl pyruvate (1a) and Oxone/NaHCO3, complete destruction of bacteria such as Staphylococcus aureus and fungus Penicillium corylophilum was achieved within 5 min at 20 degrees C at neutral pH. Highly chemical-resistant bacterial endospores of Bacillus cereus could also be destroyed. The high antibacterial activity of 1a could be attributed to its strong electron-withdrawing alpha-ester group.
Wong
Man-Kin
MK
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, China. mkwong@hkusua.hku.hk
Chan
Tak-Chung
TC
Chan
Wai-Yee
WY
Chan
Wing-Kei
WK
Vrijmoed
Lilian L P
LL
O'Toole
Desmond K
DK
Che
Chi-Ming
CM
D004202:Disinfectants / Q000737:chemistry* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry* / Q000494:pharmacology; D016877:Oxidants / Q000737:chemistry*; D010407:Penicillium / Q000187:drug effects; D011773:Pyruvates / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013464:Sulfuric Acids / Q000737:chemistry*
D004202:Disinfectants; D004852:Epoxy Compounds; D016877:Oxidants; D011773:Pyruvates; D013464:Sulfuric Acids; C061799:dioxirane; C048813:potassium peroxymonosulfuric acid