[Effect of alpha-difluoromethylornithine and polyhexamethyleneguanidine (PMG), polyamine biosynthesis inhibitors on leucosis L1210 growth kinetics and life expectancy of animals with cancer].
The article deals with the study of polyamines content and y-glutamiltranspeptidase (gamma-GTP) activity in leucosis L1210 cells under the influence of inhibitors of polyamines synthesis such as alpha-difluoromethylornithine (alpha-DFMO) and polyhexamethylenguanidine (PMG). Injections of alpha-DFMO and PMG to animals essentially reduce putrescine and spermidine concentrations, and the levels of spermine and gamma-GTP activity increase under this influence. These modulation were associated with L1210 leucosis growth retardation. Antiblastic effect was dependent on inhibitors' doses and mode of injections' course. Under the optimum conditions the retardation index was 90-98%. The animals with retarded tumor growth had essentially longer survival time frame than blank tumor-bearing animals (index was 37.2 for a-DFMO and 67.5 for PMG).
Zaletok
S P
SP
Berdinskikh
N K
NK
Lialiushko
N M
NM
Klenov
O A
OA
Samoĭlenko
E A
EA
Lidak
M Iu
MIu
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015317:Biogenic Polyamines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D000518:Eflornithine / Q000494:pharmacology / Q000627:therapeutic use*; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use*; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008017:Life Expectancy; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents; D015317:Biogenic Polyamines; D006146:Guanidines; C060540:polyhexamethyleneguanidine; D000518:Eflornithine