No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample.
Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.
Ingason
Andrés
A
Research Institute of Biological Psychiatry, Copenhagen University Hospital, H:S Sct. Hans Hospital, DK-4000 Roskilde, Denmark.
Søeby
Karen
K
Timm
Sally
S
Wang
August G
AG
Jakobsen
Klaus D
KD
Fink-Jensen
Anders
A
Hemmingsen
Ralf
R
Berg Rasmussen
Henrik
H
Werge
Thomas
T
D016022:Case-Control Studies; D003718:Denmark; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020890:Neuregulin-1; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*; D044465:White People / Q000235:genetics
C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1