A case of angiolymphoid hyperplasia with eosinophilia (ALHE) of the upper lip.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare. We report a case and review the literature of ALHE cases involving the oral mucosa. A 40-year-old man presented with a painless, 20 x 20 mm, submucosal nodule on the upper lip. Histological examination of lip biopsy specimens revealed an increase in many small vessels. The vascular walls consisted of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.
Suzuki
Hiromi
H
Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
Hatamochi
Atsushi
A
Horie
Masaki
M
Suzuki
Toshihiro
T
Yamazaki
Soji
S
D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D001707:Biopsy, Needle; D004802:Eosinophilia / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008047:Lip Diseases / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome