Virus entry: open sesame.
Detailed information about the replication cycle of viruses and their interactions with host organisms is required to develop strategies to stop them. Cell biology studies, live-cell imaging, and systems biology have started to illuminate the multiple and subtly different pathways that animal viruses use to enter host cells. These insights are revolutionizing our understanding of endocytosis and the movement of vesicles within cells. In addition, such insights reveal new targets for attacking viruses before they can usurp the host-cell machinery for replication.
Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom. m.marsh@ucl.ac.uk
Mark
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Marsh
Ari
A
Helenius
D000818:Animals; D002966:Clathrin / Q000737:chemistry / Q000378:metabolism; D004705:Endocytosis; D005814:Genes, Viral; D006801:Humans; D007425:Intracellular Membranes / Q000737:chemistry; D008954:Models, Biological; D021381:Protein Transport; D011991:Receptors, Virus / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction; D014771:Virion / Q000235:genetics; D019065:Virus Assembly; D016662:Virus Integration; D014779:Virus Replication
D002966:Clathrin; D011991:Receptors, Virus