A multimodal laser Doppler and endosonographic distension device for studying mechanosensation and mucosal blood flow in the oesophagus.
We describe the development of a multimodal device combining bag distension, manometry, high frequency intraluminal ultrasound, laser Doppler flowmetry and symptom registration. Bench tests showed that the different modalities did not influence each other. During bag distension we obtained high quality images of the oesophageal wall for computing biomechanical parameters, and laser Doppler signals showing variation in mucosal perfusion. We conclude that the principle of measurement is sound and that the device can provide a basis for further studies.
Institute of Medicine, University of Bergen, Bergen, Norway. dag.hoff@helse-bergen.no
D A L
DA
Hoff
H
H
Gregersen
S
S
Odegaard
L B
LB
Nesje
K
K
Oevreboe
T
T
Hausken
O H
OH
Gilja
K
K
Matre
J G
JG
Hatlebakk
D000818:Animals; D004106:Dilatation / Q000295:instrumentation* / Q000379:methods; D019160:Endosonography; D004947:Esophagus / Q000098:blood supply* / Q000502:physiology; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation / Q000379:methods; D008365:Manometry / Q000295:instrumentation* / Q000379:methods; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology*; D013552:Swine