Functional properties of the Rab-binding domain of Rab coupling protein.
Rab-Coupling Protein (RCP) is an approximately 80-kDa, hydrophilic protein that belongs to a recently identified family of proteins that is characterized by its ability to interact with Rab11 via a highly homologous Rab-binding domain positioned at its carboxy-termini. Five members of this family have been identified; however, a number of these Rab11-FIPs, including RCP and Rip11, have several splice isoforms. RCP is involved in regulating transport of membrane-bound vesicles from the endocytic recycling compartment to the plasma membrane, and it can be found at both locations within the cell.
Andrew J
AJ
Lindsay
Nicolas
N
Marie
Mary W
MW
McCaffrey
D048868:Adaptor Proteins, Signal Transducing; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D017931:DNA Primers; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016297:Mutagenesis, Site-Directed; D020798:Two-Hybrid System Techniques; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D017931:DNA Primers; D008565:Membrane Proteins; C488966:RAB11FIP1 protein, human; D020691:rab GTP-Binding Proteins