High expression of FMNL1 protein in T non-Hodgkin's lymphomas.
We recently cloned a novel Formin-family human gene, denominated human leukocyte formin and posteriorly named as FMNL1 by the HUGO Gene Nomenclature Committee. This gene is overexpressed in lymphoid malignances and is found associated with Akt. Here, we describe the expression of the FMNL1 protein in 54 frozen biopsies of non-Hodgkin's lymphoma (NHL) patients and five reactive lymph nodes. Western blot analysis revealed expression of FMNL1 in all samples studied, although the highest expression was in T-cell NHL (P<0.05).
Favaro
Patricia M B
PM
Centro de Hematologia e Hemoterapia e Departamento de Clinica Medica, Universidade Estadual de Campinas, Brazil, and Department of Pathology and Inserm U563, Centre de Physiopathologie de Toulouse, Purpan Hospital, France.
Traina
Fabiola
F
Vassallo
Jose
J
Brousset
Pierre
P
Delsol
George
G
Costa
Fernando F
FF
Saad
Sara T O
ST
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D000080865:Formins; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics
D003598:Cytoskeletal Proteins; C476204:FMNL1 protein, human; D000080865:Formins; D009363:Neoplasm Proteins