Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: synthesis, characterization, and their interaction with plasmid DNA.
The synthesis of macrocyclic polyamine monometallic complexes containing imidazolium salt groups was reported. Their interaction with pUC19 plasmid DNA was studied. The result showed that these complexes can catalyze the DNA cleavage with unprecedented reactivity under physiological conditions.
Li
Qiang-Lin
QL
Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China.
Huang
Jun
J
Wang
Qin
Q
Jiang
Ning
N
Xia
Chuan-Qin
CQ
Lin
Hong-Hui
HH
Wu
Jiang
J
Yu
Xiao-Qi
XQ
D002384:Catalysis; D000080027:Cyclams; D004269:DNA, Bacterial / Q000737:chemistry* / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000737:chemistry*; D048288:Imidazolines / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010957:Plasmids / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000080027:Cyclams; D004269:DNA, Bacterial; D006571:Heterocyclic Compounds; D048288:Imidazolines; D019216:Metals, Heavy; D009942:Organometallic Compounds; C038072:cyclen