A novel route to dipeptides via noncondensation of amino acids: 2-aminoperfluoropropene as a synthon for trifluoroalanine dipeptides.
2-Aminoperfluoropropene has been prepared by the Mg-promoted defluorinative N-silylation of N-p-methoxyphenyl hexafluoroacetone imine and has been employed as a synthon of trifluoroalanine for the preparation of trifluoroalanine dipeptides.
Department of Applied Chemistry, Faculty of Engineering, Okayama University, Okayama 700-8530, Japan.
Yong
Y
Guo
Kana
K
Fujiwara
Kenji
K
Uneyama
D000409:Alanine / Q000031:analogs & derivatives / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D005466:Fluorocarbons / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry; D015394:Molecular Structure
C514778:2-aminoperfluoropropene; D000596:Amino Acids; D004151:Dipeptides; D005466:Fluorocarbons; C016164:3,3,3-trifluoroalanine; D008274:Magnesium; D000409:Alanine