[Serum levels for IgM and IgA antibodies to anti-trypanosoma cruzi in samples of blood from newborns from mothers with positive serology for Chagas disease].
This study compares the levels of specific antibodies IgM and IgA for Chagas in samples of blood from newborns. Three groups of cord blood samples have been analysed: a group of 42 samples from newborns, displaying positive parasitemia, of seropositive mothers (M+B+), 68 samples from newborns with negative parasitemia whose mothers were seropositive (M+B-) and a group of 45 control newborns coming from mothers with negative serology for Chagas. From the 42 M+B+ samples with congenital Chagas disease, 81 and 82.9% displayed detectable levels of IgM and IgA antibodies, respectively In the M+B- group, 70.6 and 33.8% presented antibodies of IgM and IgA classes, respectively, whereas in the control group M-B-, we detected 6% and 11.1% of IgM and IgA antibodies, respectively. The calculated sensitivity of detection of congenital cases using IgM or IgA antibodies was of 82.9% and 80.9% respectively, whereas the specificity of detection was of 29.4% for IgM antibodies and of 66.1% for IgA antibodies.
CUMETROP/LABIMED, Facultad de Medicina, Universidad Mayor de San Simón (UMSS), Cochabamba, Bolivia. patriciarohe@hotmail.com
Patricia
P
Rodriguez
Carine
C
Truyens
Cristina
C
Alonso-Vega
Amilcar
A
Flores
Marisol
M
Cordova
Eduardo
E
Suarez
Faustino
F
Torrico
Yves
Y
Carlier
D000818:Animals; D016022:Case-Control Studies; D014355:Chagas Disease / Q000151:congenital* / Q000175:diagnosis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D007231:Infant, Newborn; D012680:Sensitivity and Specificity; D014349:Trypanosoma cruzi / Q000276:immunology*
D007070:Immunoglobulin A; D007075:Immunoglobulin M