Complexes of poly(ethylene oxide)-block-poly(L-glutamate) and diminazene.
Nanoparticles with a mean hydrodynamic radius of 16 nm and low polydispersity (P.I. = 0.1) were spontaneously formed by the complexation of poly(ethylene oxide)-block-poly(L-glutamate) (PEO-b-PLGlu) with diminazene. Only one of two possible binding sites of each diminazene molecule was involved in complexation. As determined by UV-vis difference spectra measurements, the complex binding constant is on the order of 1-2 x 10(4) M(-1). Circular dichroism measurements showed that the highly water-soluble diminazene can induce and stabilize the alpha-helical secondary structure of a PLGlu block.
Thünemann
Andreas F
AF
Federal Institute for Material Research and Testing, Richard-Willstätter-Strasse 11, 12489 Berlin, Germany. andreas.thuenemann@bam.de
Schütt
Dagmar
D
Sachse
Robert
R
Schlaad
Helmut
H
Möhwald
Helmuth
H