A metallocene-pyrrolidinopyridine nucleophilic catalyst for asymmetric synthesis.
[reaction: see text] A highly active chiral 4-aminopyridine nucleophilic catalyst, available in three steps from (S,S)-hexane-2,5-diol, was applied to the asymmetric Steglich rearrangement of O-aceylated azlactones (1 mol % loading, up to 76% ee).
School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road E1 4NS, UK.
Huy V
HV
Nguyen
David C D
DC
Butler
Christopher J
CJ
Richards