Recurrent acute profound thrombocytopenia related to readministration of eptifibatide.
We describe the case of an 86-year-old woman who presented with unstable angina. She was given heparin and eptifibatide, and she underwent percutaneous coronary intervention (PCI). Shortly thereafter, she developed acute profound thrombocytopenia (6,000 platelets/mm3), which resolved after the discontinuation of heparin and eptifibatide. Four months later, she presented again with unstable angina and underwent PCI. Soon after the procedure, she again developed acute profound thrombocytopenia (2,000 platelets/mm3). To our knowledge, acute profound thrombocytopenia due to eptifibatide treatment in the same patient at two different times has not been reported before.
Department of Internal Medicine, Division of Cardiology, St. John Hospital and Medical Center, Detroit, MI 48236, USA. acheema75@yahoo.com
Aamir Adnan
AA
Cheema
Andrew Henry
AH
Teklinski
Viqar
V
Maria
Karuna
K
Chilukuri
John Joseph
JJ
Frank
Marc Oliver
MO
Gosselin
D000208:Acute Disease; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000188:drug therapy*; D000077542:Eptifibatide; D005260:Female; D006801:Humans; D010455:Peptides / Q000009:adverse effects*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012008:Recurrence; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000503:physiopathology
D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D000077542:Eptifibatide