A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs.
A global survey of RNA from 14 fetal and 12 adult human organs by RT-PCR determined the expression patterns of 790 genes encoding DNA-binding transcription factors. The data can be sorted to identify sets of transcription factors with expression relatively restricted to a given organ or to particular organ groups. These data are a resource to help define the spectrum of transcription factor control, contribute to the elucidation of transcription factor cascades responsible for the development and maintenance of each organ, and provide a baseline to study the effects of disease or developmental defects.
Kong
Y Megan
YM
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
Macdonald
Raymond J
RJ
Wen
Xiaofei
X
Yang
Peng
P
Barbera
Victor M
VM
Swift
Galvin H
GH
D016000:Cluster Analysis; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics*; D030541:Databases, Genetic; D005333:Fetus / Q000378:metabolism*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009928:Organ Specificity / Q000235:genetics; D038081:Organogenesis; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods*; D014157:Transcription Factors / Q000235:genetics*
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D014157:Transcription Factors