Enteral diet in Crohn's disease. Nutritional and therapeutic implications in patient's management.
Inflammatory bowel diseases (IBD) are often characterized by impairment of nutritional status. Crohn's disease (CD) patients, especially in the active phase of disease, show a reduced body weight, due to the reduction of lipid stores, in spite of lean mass depletion. Fat mass reduction has been correlated to an increased utilization of lipids as fuel substrate. The alterations of nutritional status are able, in turn, to influence, as independent factors, the disease course and patient prognosis. A disease's treatment based only on pharmacologic therapy, especially on corticosteroid use in the active phases, often does not take into account the relevant need for preserving a normal nutritional status. In this connection, enteral nutrition has been shown to be able to improve nutritional status and induce and maintain remission. We present some of the possible mechanisms of efficacy of enteral feeding and some rules to attempt to treat patients with IBD, especially those with Crohn's disease.
Università Cattolica del Sacro Cuore, Roma, Facoltà di Medicina e Chirurgia Agostino Gemelli, Istituto di Medicina Interna.
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Valentini
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Capristo
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Scarfone
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Mingrone
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Greco
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Gasbarrini