Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects.
Compared with saturated fat, n-3 long-chain PUFA-rich fish oil improves insulin sensitivity in rats. We studied whether n-3 long-chain PUFA could prevent insulin resistance induced by dexamethasone (a glucocorticoid) in healthy human volunteers. A group of eight subjects was studied twice after a 2 d dexamethasone treatment, before and after a 3-week supplementation with fish oil (providing daily doses of 1.1 g 20 : 5n-3 and 0.7 g 22 : 6n-3). The subjects were studied during the basal state and over the 6 h following an oral glucose load (1 g/kg). Plasma glucose fluxes were traced with [6,6-2H2]glucose and [13C]glucose (naturally 13C-enriched corn glucose). Substrate oxidation was obtained from indirect calorimetry. Following fish oil supplementation, plasma glucose fluxes and substrate oxidation were maintained despite a 17 % reduction (P<0.05) in the area under the curve of plasma insulin response, suggesting an insulin-sensitizing effect.
Equipe d Accueil 948 Oxylipids, Laboratoire Régional de Nutrition Humanaine, Faculté de Médecine de Brest & CHU, F-29 200 Brest, France. Jacques.delarue@univ-brest.fr.
Jacques
J
Delarue
Chang-Hong
CH
Li
Richard
R
Cohen
Charlotte
C
Corporeau
Brigitte
B
Simon
D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003907:Dexamethasone / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000378:metabolism; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000378:metabolism; D015118:Eicosapentaenoic Acid / Q000378:metabolism; D005260:Female; D005395:Fish Oils / Q000378:metabolism*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D010084:Oxidation-Reduction
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005395:Fish Oils; D007328:Insulin; D004281:Docosahexaenoic Acids; D003907:Dexamethasone; D015118:Eicosapentaenoic Acid; D005947:Glucose