HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks.
Regulated timing of cell division cycles, and geometrical precision in the planar orientation of cell division, are critical during organismal development and remain important for the maintenance of polarized structures in adults. Mounting evidence suggests that these processes are coordinated at the centrosome through the action of proteins that mediate both cell cycle and cell attachment. Our recent work identifying HEF1 as an activator of the Aurora A kinase suggests a novel hub for such integrated signaling. We suggest that defects in components of the machinery specifying the temporal and spatial integration of cell division may induce cancer and other diseases through pleiotropic effects on cell migration, proliferation, apoptosis, and genomic stability.
Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Elena N
EN
Pugacheva
Erica A
EA
Golemis
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D064127:Aurora Kinases; D002448:Cell Adhesion; D002453:Cell Cycle / Q000502:physiology*; D006801:Humans; D010750:Phosphoproteins / Q000172:deficiency / Q000378:metabolism*; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; C099942:NEDD9 protein, human; D010750:Phosphoproteins; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases