Deaths attributed to X-ray contrast media on U.S. death certificates.
OBJECTIVE
The objectives of our study were to determine the number, rate, and types of deaths attributed to specific X-ray contrast media on the basis of U.S. death certificates and to attempt to assess the comparative safety of commonly used diagnostic X-ray contrast agents using death certificate information.


CONCLUSIONS
From 1999 through 2001, deaths attributed to the International Classification of Diseases (ICD) code for contrast media occurred at the rate of 1.1-1.2 per million contrast media packages distributed. An analysis of 1999 death certificates indicated that most deaths attributed to contrast media predictably were associated with renal failure or nephropathy and anaphylaxis or allergic reactions. Risk assessment of the comparative safety of classes or agents was limited by lack of specific contrast media names. Names of administered contrast agents should be recorded in patients' medical records and communicated to primary care physicians and certifiers of death in the event of serious sequelae after an identified recent radiologic procedure.
Division of Drug Risk Evaluation, Food and Drug Administration, HFD-433, Silver Spring, MD 20993, USA.
Diane K
DK
Wysowski
Parivash
P
Nourjah
D002423:Cause of Death; D003287:Contrast Media / Q000009:adverse effects*; D003644:Death Certificates; D003952:Diagnostic Imaging; D006801:Humans; D014481:United States / Q000453:epidemiology
D003287:Contrast Media