N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
Eli Lilly and Company, Ltd, Lilly Research Centre, Windlesham, Surrey, GU20 6PH, UK.
J R
JR
Boot
S L
SL
Boulet
B P
BP
Clark
M J
MJ
Cases-Thomas
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L
Delhaye
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K
Diker
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J
Fairhurst
J
J
Findlay
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Gallagher
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J
Gilmore
J R
JR
Harris
J J
JJ
Masters
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SN
Mitchell
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M
Naik
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Simmonds
S M
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Smith
S J
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Richards
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Timms
M A
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Whatton
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Wolfe
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Wood
D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009638:Norepinephrine; D010880:Piperidines; D017367:Selective Serotonin Reuptake Inhibitors