Sprouty and cancer: the first terms report.
The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.
Lo
Ting Ling
TL
Signal Transduction laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, #6-01, Proteos, Singapore, 138673.
Fong
Chee Wai
CW
Yusoff
Permeen
P
McKie
Arthur B
AB
Chua
Mei-Sze
MS
Leung
Hing Y
HY
Guy
Graeme R
GR
D000818:Animals; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000378:metabolism; D008565:Membrane Proteins / Q000096:biosynthesis / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D010750:Phosphoproteins / Q000096:biosynthesis / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D015398:Signal Transduction; D014018:Tissue Distribution
D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D010750:Phosphoproteins; C486055:SPRY1 protein, human