[Clinicopathologic and radiologic features of dysembryoplastic neuroepithelial tumors].
OBJECTIVE
To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT).


METHODS
The clinical presentations, radiologic findings, histologic features and immunophenotype of 9 cases of DNT were analyzed.


RESULTS
The age of patients ranged from 12 to 51 years (mean age = 32 years). Most presented with partial seizures, sometimes accompanied by transient aphasia, agraphia and decreased visual acuity. One case was asymptomatic and discovered incidentally during a routine check-up. All patients had no neurological deficit found on physical examination. All tumors were located in the supratentorial cerebral cortex. There was no peritumoral edema or space-occupying effect on radiologic examination. The tumors involved either frontal lobe (number = 4), temporal lobe (number = 4), frontoparietal lobe (number = 1) . Two cases showed cystic changes. Two histologic variants of DNT were recognized: simple (number = 3) and complex (number = 6). Simple variant was composed mainly of the glioneuronal element, accompanied by surrounding oligodendrocyte-like cells, and the complex variant contained a low-grade glioma component, in addition to the glioneuronal element and sometimes foci of cortical dysplasia.


CONCLUSIONS
DNT is a benign tumor with excellent prognosis after surgical excision. Local recurrence is rare. Complex variant of DNT needs to be distinguished from other types of low-grade glioma.
Wang
Fu-lin
FL
Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China. wfl301a@vip.sina.com
Li
Xiang-hang
XH
Gui
Qiu-ping
QP
Liu
Lin
L
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016900:Neurofilament Proteins / Q000378:metabolism; D009836:Oligodendroglia / Q000473:pathology / Q000648:ultrastructure; D009418:S100 Proteins / Q000378:metabolism; D015996:Survival Rate; D016708:Synaptophysin / Q000378:metabolism
D016900:Neurofilament Proteins; D009418:S100 Proteins; D016708:Synaptophysin