Bacterial adhesion and entry into host cells.
Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV pili to establish a complex host/pathogen molecular crosstalk that leads to subversion of cellular functions and establishment of disease.
Pizarro-Cerdá
Javier
J
Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, F-75015 France. pizarroj@pasteur.fr
Cossart
Pascale
P
D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000472:pathogenicity*; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000502:physiology; D004847:Epithelial Cells / Q000382:microbiology; D010861:Fimbriae, Bacterial / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D037521:Virulence Factors / Q000235:genetics
D001425:Bacterial Outer Membrane Proteins; D037521:Virulence Factors