MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes.
The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs.
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-ohsawa 1-1, Hachioji, Tokyo 192-0397 Japan.
Yoko
Y
Miyake
Humika
H
Togashi
Mitsuru
M
Tashiro
Hiroshi
H
Yamaguchi
Shuji
S
Oda
Megumi
M
Kudo
Yoshiyuki
Y
Tanaka
Yoshinori
Y
Kondo
Ryuichi
R
Sawa
Takashi
T
Fujimoto
Tomoya
T
Machinami
Akira
A
Ono
D020029:Base Pairing; D002413:Cations, Divalent / Q000737:chemistry; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013941:Thymine / Q000737:chemistry*
D002413:Cations, Divalent; D004247:DNA; D008628:Mercury; D013941:Thymine