The subthalamic nucleus: From response selection to execution.
The involvement of the subthalamic nucleus in physiological and pathological motor behaviour has now largely been established. Clinical observations in patients suffering from Parkinson disease treated with Deep Brain Stimulation of the STN show that these patients can suffer from postoperative changes in non-motor behaviour mainly involving alterations in cognitive functions. The involvement of the STN in cognition has initially been demonstrated by non-human studies investigating the effects of STN lesions and stimulations on cognitive parameters. In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit.
Tan
Sonny K H
SK
Department of Psychiatry & Neuropsychology, Division Cellular Neurosciences, Maastricht University, Maastricht, The Netherlands.
Temel
Yasin
Y
Blokland
Arjan
A
Steinbusch
Harry W M
HW
Visser-Vandewalle
Veerle
V
D000818:Animals; D006801:Humans; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D020531:Subthalamic Nucleus / Q000033:anatomy & histology* / Q000502:physiology*