Causal role of Helicobacter pylori infection in gastric cancer.
Gastric cancer is the second most frequent cancer in the world, accounting for a large proportion of all cancer cases in Asia, Latin America, and some countries in Europe. Helicobacter pylori (H pylori) is regarded as playing a specific role in the development of atrophic gastritis, which represents the most recognized pathway in multistep intestinal-type gastric carcinogenesis. Recent studies suggest that a combination of host genetic factors, bacterial virulence factors, and environmental and lifestyle factors determine the severity of gastric damage and the eventual clinical outcome of H pylori infection. The seminal discovery of H pylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication.
Ando
Takafumi
T
Goto
Yasuyuki
Y
Maeda
Osamu
O
Watanabe
Osamu
O
Ishiguro
Kazuhiro
K
Goto
Hidemi
H
D000942:Antigens, Bacterial / Q000502:physiology; D001426:Bacterial Proteins / Q000502:physiology; D016207:Cytokines / Q000235:genetics; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008019:Life Style; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000209:etiology* / Q000517:prevention & control
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D016207:Cytokines; C080866:cagA protein, Helicobacter pylori