Identification of steroid hormone-regulated genes in breast cancer.
The measurement of the expression of hormonally regulated genes in breast cancer may provide an indication of its hormone responsiveness. In addition, these genes may provide novel therapeutic targets. This chapter reviews the hormonally responsive genes that have been identified in breast cancer cell lines and tumors, using differential hybridization, differential display, serial analysis of gene expression, and array technology. The biological relevance of the genes identified is discussed.
The University of Newcastle upon Tyne, Northern Institute for Cancer Research, Medical School, UK.
Bruce R
BR
Westley
Felicity E B
FE
May
D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009693:Nucleic Acid Hybridization / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D011960:Receptors, Estrogen / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen