A highly enantioselective lewis basic organocatalyst for reduction of N-aryl imines with unprecedented substrate spectrum.
L-Pipecolinic acid derived formamides have been developed as highly efficient and enantioselective Lewis basic organocatalysts for the reduction of N-aryl imines with trichlorosilane. Catalyst 4b afforded high isolated yields (up to 98%) and enantioselectivities (up to 96%) under mild conditions with an unprecedented substrate spectrum.
Wang
Zhouyu
Z
Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
Ye
Xiaoxia
X
Wei
Siyu
S
Wu
Pengcheng
P
Zhang
Anjiang
A
Sun
Jian
J