In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine.
Twenty plants identified and selected from Southwest and Middle belt Nigerian antimalarial ethnopharmacology were evaluated for in vitro cytotoxicity using the brine shrimp lethality assay. The methanol extracts of 20 plant samples from 11 plant families were subjected to the assay. Of the studied plants, Lippia multiflora and Morinda lucida bark were found to be cytotoxic, with LC(50) values of 1.1 and 2.6 microg/ml, respectively. The least toxic plant extract was Bridelia micrantha (LC(50) value >9.0 x 10(6) microg/ml). Most of the plants were found to be relatively non-toxic.
Ajaiyeoba
E O
EO
Faculty of Pharmacy, Department of Pharmacognosy, University of Ibadan, Ibadan, Nigeria. edajaiye@yahoo.com
Abiodun
O O
OO
Falade
M O
MO
Ogbole
N O
NO
Ashidi
J S
JS
Happi
C T
CT
Akinboye
D O
DO
D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D001156:Artemia / Q000187:drug effects; D007928:Lethal Dose 50; D016488:Medicine, African Traditional; D000432:Methanol / Q000737:chemistry; D009549:Nigeria; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal / Q000737:chemistry* / Q000633:toxicity; D018675:Toxicity Tests
D000962:Antimalarials; D010936:Plant Extracts; D000432:Methanol