Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells.
Cytokines are involved in directing the activation of natural killer (NK) cells. NK cells are involved in the recognition of cells that have been altered; thus they do not recognize specific insults to the host, but when activated, are capable of destroying infected cells directly, as well as promoting the recruitment and response of the other components of the immune system by the release of cytokines and chemokines. It is these properties that have made NK cells a critical part of innate immunity and adaptive immunity, and they play a principal role linking innate and adaptive immunity by the recruitment of an adaptive immune response to an innate immune reaction.
Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Center for Cancer Research, Frederick, MD 21702, USA. youngh@ncifcrf.gov
Howard A
HA
Young
John
J
Ortaldo
D016207:Cytokines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007110:Immunity, Active; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000502:physiology; D008264:Macrophages / Q000276:immunology; D018448:Models, Immunological; D011956:Receptors, Cell Surface / Q000276:immunology
D016207:Cytokines; D007376:Interleukin-2; D016209:Interleukin-8; D011956:Receptors, Cell Surface; D007371:Interferon-gamma