Changes in visual evoked potentials, lipid peroxidation and antioxidant enzymes in rats exposed to restraint stress: effect of L-carnitine.
The purpose of our study was to investigate the effects of L-carnitine on lipid peroxidation, Visual Evoked Potentials (VEPs) and antioxidant enzyme activities such as superoxide dismutase and catalase in rats exposed to chronic restraint stress. Forty male Wistar rats, aged three months were used. They were equally divided into four groups: control (C), the group exposed to restraint stress (R), the group treated with L-carnitine(L) and the group exposed to stress and treated with L-carnitine (RL). Chronic restraint stress was applied for 21 days (1 h/day) and L-carnitine (50 mg/kg/day) was given by gavage to the L and RL groups for the same period. Brain and retina levels of thiobarbituric acid reactive substances (TBARS) were significantly increased in the R group and were not altered in the L group compared to the C group. Brain and retina TBARS levels were lower in the RL group than in the R group. Brain and retina superoxide dismutase and catalase activities were significantly decreased in the L and R groups compared to the C group. L-carnitine pretreatment had no significant effect on superoxide dismutase and catalase activity in the RL group. All latencies of VEP components were prolonged in the R and L groups with respect to the C group. L-carnitine increased the latencies of all VEP components in the L group whereas shortened them in the RL group compared to their control groups. L-carnitine may be a promising agent for the prevention of VEP and TBARS alterations caused by stress.
Department of Biophysics, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
Narin
N
Derin
Selcen
S
Aydin
Piraye
P
Yargiçoglu
Aysel
A
Agar
D000704:Analysis of Variance; D000818:Animals; D002331:Carnitine / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism*; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000379:methods; D013312:Stress, Physiological / Q000188:drug therapy* / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014803:Vitamin B Complex / Q000627:therapeutic use*
D017392:Thiobarbituric Acid Reactive Substances; D014803:Vitamin B Complex; D002374:Catalase; D013482:Superoxide Dismutase; D002331:Carnitine