Synthesis of polyamines via hydroaminomethylation of alkenes with urea--a new, effective and versatile route to dendrons and dendritic core molecules.
Polyamines, structurally related to putrescines and spermidines, are easily obtainable via hydroaminomethylation of methylallylphthalimide with primary or secondary amines. In addition, hydroaminomethylation of monoolefins with urea as a synthetic equivalent for ammonia, in contrast to other methods (e.g. the alkylation of ammonia or ammonium salts), allows selective synthesis of symmetric tertiary amines. By combining both methods dendrons and dendrimer cores are conveniently obtained.
Müller
Kai-Sven
KS
Universität Dortmund, Fachbereich Chemie, Organische Chemie I, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Koç
Fikret
F
Ricken
Stefan
S
Eilbracht
Peter
P
D000475:Alkenes / Q000737:chemistry*; D002621:Chemistry / Q000379:methods*; D008745:Methylation; D011073:Polyamines / Q000138:chemical synthesis*; D014508:Urea / Q000737:chemistry*
D000475:Alkenes; D011073:Polyamines; D014508:Urea