MRI-guided immunotherapy development for multiple sclerosis in a primate.
Multiple sclerosis is a serious neurological disease that affects 1 in 1000 young adults in Europe and the USA. The development of an effective therapy for this enigmatic disease is plagued by the failure of many treatments to reproduce in patients the promising effects observed in animal models. This review describes a new preclinical model in a non-human primate that might help to bridge the gap between currently used animal models and the patients.
't Hart
Bert A
BA
Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. hart@bprc.nl
Smith
Paul
P
Amor
Sandra
S
Strijkers
Gustav J
GJ
Blezer
Erwin L A
EL
D000818:Animals; D001921:Brain / Q000473:pathology; D002144:Callithrix; D004195:Disease Models, Animal; D007167:Immunotherapy; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000628:therapy*