Angiotensinogen gene variants and small-for-gestational-age infants.
In 2003, the angiotensinogen (AGT) gene was found to be associated with infants small for gestational age (SGA). The present study of 107 pregnancies affected by SGA infants and 101 normal pregnancies was designed to further investigate this association. Maternal or fetal AGT genotype or haplotype frequencies did not differ between SGA and normal pregnancies (P > 0.35). Quantitative trait analysis of mothers with normal pregnancies demonstrated an association between AGT haplotype and blood pressure and body mass index at antenatal booking (P = 0.04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women.
Division of Clinical Chemistry, Institute of Genetics, School of Molecular Medical Sciences, University Hospital, Nottingham, UK.
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Tower
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Chappell
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Kalsheker
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Baker
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Morgan
D000328:Adult; D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000502:physiology*; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy
D000808:Angiotensinogen