[Type IV secretion system and their effectors: an update].
Subversion of eukaryotic hosts by bacterial pathogens requires specialized macromolecules secretion systems delivering virulence factors either into the environment or directly into host cells. Transport of molecules across bacterial and eukaryotic membranes is a process requiring multi-component machineries called secretion systems. This review focuses on the Type IV secretion system. This complex is required for genetic exchange (DNA transport) and secretion of effectors (proteins, macromolecules, DNA-proteins complex) into target cells. They transport a wide variety of substrates including large DNA/protein complexes, multi protein toxins, or individual proteins. We describe recent advances on the structure and the function of this secretion system, their effectors and their effects on the functions of eukaryotic cell.
Inserm U 431, faculté de médecine, avenue Kennedy, 30908 Nîmes cedex 02, France. jean-philippe.lavigne@univ-montp1.fr
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JP
Lavigne
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Botella
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O'Callaghan
D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000175:diagnosis*; D001426:Bacterial Proteins / Q000032:analysis; D004269:DNA, Bacterial / Q000032:analysis; D006801:Humans; D014774:Virulence
D001426:Bacterial Proteins; D004269:DNA, Bacterial