Drug eruptions at five institutes in Bangkok.
The study was performed in five hospitals in Bangkok for a period of one year. All in- and outpatients who developed drug eruption from January to December 2001 were enrolled into the study. Physical examinations and complete history-taking were performed by one of the authors. A skin biopsy was done to confirm the diagnosis in every suspected case. Oral challenge test was performed to obtain a definite diagnosis only in some patients with informed consent. Among 212 patients, the most common causative drugs were antimicrobial agents with cephalosporin group in the highest rank. Maculopapular rash was the most common type of drug eruption followed by urticaria and photosensitivity reaction. It was concluded that antimicrobial agents were the predominant causative agents and maculopapular eruption was the most frequent clinical manifestation. New kinds of antimicrobial agents, anti-inflammatory drugs and lipid lowering agents could cause various patterns of drug eruption.
Division of Dermatology, Department of Medicine, Ramathibodi Hospital Medical School, Mahidol University, Bangkok 10400, Thailand.
Siripen
S
Puavilai
Nopadon
N
Noppakun
Chasuree
C
Sitakalin
Vichit
V
Leenutaphong
Penpun
P
Wattanakrai
Artit
A
Nakakes
Kanokvalai
K
Kulthanan
Pravit
P
Asawanonda
Ratsanee
R
Akaraphan
Poohglin
P
Tresukosol
Puan
P
Suthipinittharm
Pitchaya
P
Somburanasin
Somyos
S
Charuwichitratana
Natta
N
Rajatanavin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D002491:Central Nervous System Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003875:Drug Eruptions / Q000175:diagnosis* / Q000453:epidemiology; D017723:Drug Utilization Review; D005076:Exanthema / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010607:Pharmacy Service, Hospital; D011446:Prospective Studies; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D002491:Central Nervous System Agents