Disruption of metabolic pathways--perspectives for the treatment of cancer.
Several growth-promoting signaling pathways have tight molecular connections with metabolic-related signal transduction systems. By controlling these pathways, cancer cells gain autonomy over energy-acquiring systems and, thus, expand their potential for proliferation. Here, we discuss the use of drug and antisense oligonucleotide approaches to inhibit metabolic pathways in cancer cells and their potential use in the therapeutics of cancer.
Araujo
Eliana P
EP
Department of Internal Medicine, State University of Campinas, Brazil.
Carvalheira
José Barreto
JB
Velloso
Licio A
LA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects*
D000970:Antineoplastic Agents; D016376:Oligonucleotides, Antisense; D019869:Phosphatidylinositol 3-Kinases