Directed ortho metallation of deep cavity cavitands: functionalizing molecular concavity.
Directed ortho metallation (DOM) processes have been used to functionalize the cavity and rim of title cavitand 1. The preorganization of the host resulted in a considerable reduction in the range of products produced. Thus, whereas sixty-nine products are possible from per-functionalization, only twelve were observed when the host was treated with three different alkyllithiums.
Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
Zachary R
ZR
Laughrey
Bruce C
BC
Gibb