[Acute pancreatitis during the treatment of relapsed acute promyelocytic leukemia with As2O3].
A 77-year-old man suffered from acute pancreatitis during the treatment of relapsed acute promyelocytic leukemia with As2O3. He presented with epigastralgia on day 25 during the treatment with As2O3. Pancreatic enzyme levels were elevated and the computed tomography scan of the abdomen showed swelling of the pancreas. As acute pancreatitis due to As2O3 was suspected, As2O3 was discontinued. Intravenous gabexate mesilate was administered, and the pancreatitis improved. Acute pancreatitis should be considered as a possible complication during treatment with As2O3.
First Department of Internal Medicine, Osaka Medical College.
Takeshi
T
Yamano
Taiji
T
Yokote
Toshikazu
T
Akioka
Satoshi
S
Hara
Tomoko
T
Oka
Motomu
M
Tsuji
Toshiaki
T
Hanafusa
D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000009:adverse effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D010087:Oxides / Q000009:adverse effects*; D010195:Pancreatitis / Q000139:chemically induced*; D012008:Recurrence
D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide