N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
Boot
J R
JR
Eli Lilly and Company, Ltd, Lilly Research Centre, Windlesham, Surrey, GU20 6PH, UK.
Boulet
S L
SL
Clark
B P
BP
Cases-Thomas
M J
MJ
Delhaye
L
L
Diker
K
K
Fairhurst
J
J
Findlay
J
J
Gallagher
P T
PT
Gilmore
J
J
Harris
J R
JR
Masters
J J
JJ
Mitchell
S N
SN
Naik
M
M
Simmonds
R G
RG
Smith
S M
SM
Richards
S J
SJ
Timms
G H
GH
Whatton
M A
MA
Wolfe
C N
CN
Wood
V A
VA
D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009638:Norepinephrine; D010880:Piperidines; D017367:Selective Serotonin Reuptake Inhibitors