Congenital heart diseases in twin pregnancies.
OBJECTIVE
To find connection between the type of congenital heart malformations and twin pregnancies.


METHODS
Retrospective analysis of data of fetal cardiology database between 1 January 1996 and 30 November 2003.


RESULTS
In single pregnancies 455 and in twin pregnancies 31 severe congenital heart malformations were diagnosed prenatally. In monozygotic twin pregnancies 36% of heart malformations were pulmonary stenosis and 45% endocardial fibroelastosis, which is significantly higher than in single pregnancies. In dizygotic twin pregnancies Ebstein malformation was significantly more frequent than in single pregnancies. With the exception of Ebstein malformation in dichorionic and dizygotic twin pregnancies the cardiac malformations were similar to the ones in single pregnancies.


CONCLUSIONS
The twin pregnancy alone can be considered as indication for fetal echocardiography. The type of congenital heart malformations detected in monochorial twin pregnancies was different from those found in single, dizygotic or dichorionic twin pregnancies. Chorionicity seems to be more important than zygosity.
Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary. hajdu@noi1.sote.hu
J
J
Hajdu
A
A
Beke
T
T
Marton
E
E
Hruby
B
B
Pete
Z
Z
Papp
D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D010929:Placentation; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic