Bullous reaction to topical methchlorethamine in mycosis fungoides.
We describe a patient with mycosis fungoides who developed a bulla shortly after the start of topical methchlorethamine. Dermal-epidermal separation has been reported to occur with topical methchlorethamine on histological examination. It is plausible that the compromised dermal-epidermal junction may manifest as a clinical bulla after a secondary insult. To our knowledge, clinical bulla formation due to topical methchlorethamine has not been reported.
Department of Dematology, Texas Tech University Health Science Center, Lubbock, TX 79430, USA. mjwells@pol.net
Jeff
J
Freed
Michael
M
Wells
Cloyce
C
Stetson
Lee
L
Dongwoo
D000368:Aged; D001768:Blister / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects*; D009182:Mycosis Fungoides / Q000188:drug therapy*; D012867:Skin / Q000473:pathology
D008466:Mechlorethamine