Zebrafish z-otu, a novel Otu and Tudor domain-containing gene, is expressed in early stages of oogenesis and embryogenesis.
Several studies have suggested that Otu domain had de-ubiquitinating activity and Tudor domain was important for the formation of germ cells. Here, we reported a novel zebrafish ovary-specific gene containing Otu and Tudor domain, z-otu, which was expressed at stages I-III oocytes and embryonic stages from zygotes to early blastula during embryonic cells maintained their totipotency. Therefore, z-otu might link the ubiquitin signaling pathway to early oogenesis and maintaining the totipotency of embryonic cell.
Mo
Saijun
S
Laboratory of Molecular Genetics and Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Song
Ping
P
Lv
Daoyuan
D
Chen
Yungui
Y
Zhou
Wei
W
Gong
Wuming
W
Zhu
Zuoyan
Z
D000595:Amino Acid Sequence; D000818:Animals; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000166:cytology; D047108:Embryonic Development / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D009866:Oogenesis / Q000235:genetics*; D010053:Ovary / Q000166:cytology; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics*; D029961:Zebrafish Proteins / Q000737:chemistry / Q000235:genetics*
D012333:RNA, Messenger; D029961:Zebrafish Proteins; D003546:Cysteine Endopeptidases; C509509:alg13 protein, zebrafish