A short total synthesis of (+/-)-aspidospermidine.
A cascade radical cyclization starting from an amidyl radical has been used for the construction of (+/-)-aspidospermidine. This approach has also been developed for the preparation of a tricycle whose framework is contained in the stemona alkaloids.
Sharp
Lisa A
LA
Laboratoire de Synthèse Organique associé au CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
Zard
Samir Z
SZ
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D030009:Aspidosperma / Q000737:chemistry; D003500:Cyclization; D026121:Indole Alkaloids; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D041901:Stemonaceae / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D026121:Indole Alkaloids; D007211:Indoles; D011804:Quinolines; C409672:aspidospermidine