Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5.
Histatin 5, a human salivary protein with broad-spectrum antifungal activity, is remarkably ineffective against Candida glabrata. Fluconazole resistance in this fungus is due in most cases to upregulation of CgCDR efflux pumps. We investigated whether the distinct resistance of C. glabrata to histatin 5 is related to similar mechanisms.
Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany St., CABR W-201, Boston, Massachusetts 02118, USA. helmer@bu.edu
Eva J
EJ
Helmerhorst
Caterina
C
Venuleo
Dominique
D
Sanglard
Frank G
FG
Oppenheim
D000935:Antifungal Agents / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D003470:Culture Media; D025141:Drug Resistance, Fungal / Q000187:drug effects / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D005800:Genes, Fungal; D054808:Histatins; D006801:Humans; D012471:Salivary Proteins and Peptides / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; C068075:HTN3 protein, human; D054808:Histatins; D012471:Salivary Proteins and Peptides