Efficacy of an injectable formulation of eprinomectin against Psoroptes cuniculi, the ear mange mite in rabbits.
Thirty rabbits naturally infected with ear mange mite, Psoroptes cuniculi, were subcutaneously administrated with a single dose of eprinomectin at 100, 200 and 300 microg/kg body weight or vehicle on day 0. The extent of lesions was scored on day -6 (prior to treatment), day 0 (treated), days 7, 14, 21, 28 and 35, the ear scabs were collected simultaneously; mites in scabs were examined and counted. The results showed that a single dose of eprinomectin at 200 or 300 microg/kg body weight following subcutaneous administration was able to eliminate P. cuniculi infection in rabbits, and a dose of eprinomectin at 100 microg/kg could significantly reduce mites but was unable to eliminate P. cuniculi.
College of Veterinary Medicine, China Agricultural University, 100094 Beijing, China.
Baoliang
B
Pan
Ming
M
Wang
Farong
F
Xu
Yuwan
Y
Wang
Yuntang
Y
Dong
Zhende
Z
Pan
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004423:Ear / Q000469:parasitology; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000627:therapeutic use*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D040042:Psoroptidae / Q000187:drug effects*; D011817:Rabbits / Q000469:parasitology*; D011897:Random Allocation; D016896:Treatment Outcome
D007306:Insecticides; D007559:Ivermectin; C101434:eprinomectin