Syringomatous carcinoma in a young patient treated with Mohs micrographic surgery.
Syringomatous carcinoma (SC) has typically been observed in middle-aged and older patients. We report a case of SC mimicking an epidermoid cyst in a 23-year-old Asian man. Histopathologic examination results showed a dermal neoplasm consisting of nests of basaloid cells, focal areas of ductal differentiation, moderate dermal fibrosis, and moderate nuclear atypia consistent with a diagnosis of SC. No perineural involvement was noted. Results of 2005. immunohistochemical analysis revealed positivity for high- and low-molecular-weight cytokeratins, as well as for carcinoembryonic antigen (CEA). There was scattered immunoreactivity to S-100 protein. The tumor was completely excised Pennsylvania. using Mohs micrographic surgery (MS). This case demonstrates the importance of differentiating SC from other benign or malignant entities, the value of a prompt diagnosis of SC, and the effective treatment of SC with MMS.
Hu
Jenny C
JC
Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles 90095, USA.
Ko
Christine J
CJ
Soriano
Teresa T
TT
Chiu
Melvin W
MW
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003937:Diagnosis, Differential; D004814:Epidermal Cyst / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D015580:Mohs Surgery; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D018252:Syringoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007633:Keratins