Keeping single minded expression on the straight and narrow.
Recent Developmental Cell papers by De Renzis et al. (2006) and Bardin and Schweisguth (2006) show that members of the Bearded family interact with Neuralized to regulate trafficking of the Notch ligand Delta. This allows precise control of Notch signaling and restriction of single minded expression to a single row of cells.
Chitnis
Ajay B
AB
Laboratory of Molecular Genetics, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D051880:Receptors, Notch; D044767:Ubiquitin-Protein Ligases; C109219:Brd protein, Drosophila; C497759:N protein, Drosophila; C064045:delta protein; C089449:sim protein, Drosophila; C071006:neur protein, Drosophila