[Pure red cell aplasia following major ABO-incompatible allogeneic hematopoietic stem cell transplantation].
OBJECTIVE
To study clinical characteristics and outcome of pure red cell aplasia (PRCA) following major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT).


METHODS
Variables including sex, age, stem cell source, granulocyte engraftment time, blood transfusion and isoagglutinin type against donor RBC were analyzed to identify risk factors for the development of PRCA.


RESULTS
Twelve of 100 patients received major ABO-incompatible allo-HSCT developed PRCA, with out any effect on incidence of aGVHD and CMV infection. ABO blood groups of recipient/donor pairs of these twelve PRCA patients were O/A in nine, B/A in one and O/B in two. Patients with anti-A isoagglutinins against donor RBC developed PRCA more frequently than those with anti-B (10/49 vs 2/49). Median duration to the recovery of erythropoiesis tended to be longer in patients with PRCA (PRCA vs non-PRCA, 203.5 vs. 76 days, P < 0.05 ). Median durations to the disappearance of incompatible isoagglutinins tended to be longer in patients with PRCA (PRCA vs. non-PRCA, 150.5 vs. 60 days,P <0.05) and in those with anti-A isoagglutinins (anti-A vs anti-B, 90 vs 55 days, P < 0.05).


CONCLUSIONS
ABO blood group of O/A in recipient/donor pair was the only high risk factor for PRCA after major ABO-incompatible allo-HSCT.
People's Hospital, Peking University, Beijing, China.
Xiao-jun
XJ
Huang
Dai-hong
DH
Liu
Lan-ping
LP
Xu
Wei
W
Han
Qian
Q
Jiang
Yu-hong
YH
Chen
Yao-chen
YC
Zhang
Kai-yan
KY
Liu
Li
L
Bao
Dao-pei
DP
Lu
D000017:ABO Blood-Group System / Q000276:immunology; D001787:Blood Group Incompatibility; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors
D000017:ABO Blood-Group System