Practical use of MESNA in atelectatic ears and adhesive otitis media.
OBJECTIVE
MESNA is a synthetic sulfur compound that produces mucolysis by disrupting disulfide bonds. This study aimed to address indications and technique of MESNA application in otologic surgery, especially in retraction pockets and adhesive otitis media.


METHODS
MESNA application was performed in 42 ears of 39 patients. The diagnoses were retraction pockets fixed to incudostapedial joint, stapes or promontorium, and adhesive otitis media in 24 and 17 ears, respectively. Calculations were performed according to 24 ears of 23 patients with follow-up data.


RESULTS
One or more of the following surgical interventions were performed: MESNA application alone and ventilation tube insertion, reinforcement or mastoidectomy in addition to MESNA application. Sensorineural hearing loss was not encountered after MESNA application. The operation was successful in 79.2%. Overall revision surgery was needed in 20.8% of the ears. In 71.4% of the ears treated with MESNA alone, revision surgery was needed.


CONCLUSIONS
In the light of our experience, we advocate the use of MESNA in atelectatic ears, because it makes the operation easy and safe by allowing elevation of the tympanic membrane by its mechanical and chemical actions.
Department of Otolaryngology, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey.
Metin
M
Yilmaz
Nebil
N
Goksu
Ismet
I
Bayramoglu
Yildirim A
YA
Bayazit
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004427:Ear Diseases / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D015080:Mesna / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010033:Otitis Media / Q000188:drug therapy* / Q000601:surgery; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000473:pathology*
D020011:Protective Agents; D015080:Mesna