An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study.
OBJECTIVE
To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs.


METHODS
Cohort, multicentre, observational study of 198 ICUs in 24 European countries.


METHODS
All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.


RESULTS
During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.


CONCLUSIONS
Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.
Sprung
Charles L
CL
Hadassah Hebrew University, Medical Center, Department of Anaesthesiology and Critical Care Medicine, P.O. Box 1200, 91120, Jerusalem, Israel. sprung@cc.huji.ac.il
Sakr
Yasser
Y
Vincent
Jean-Louis
JL
Le Gall
Jean-Roger
JR
Reinhart
Konrad
K
Ranieri
V Marco
VM
Gerlach
Herwig
H
Fielden
Jonathan
J
Groba
C B
CB
Payen
Didier
D
D000368:Aged; D015331:Cohort Studies; D016638:Critical Illness; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000453:epidemiology / Q000503:physiopathology*; D012720:Severity of Illness Index; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology