Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.
Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. dvijayku@hotmail.com
Dange
D
Vijaykumar
Paul A
PA
Sprengeler
Michael
M
Shaghafi
Jeffrey R
JR
Spencer
Brad A
BA
Katz
Christine
C
Yu
Roopa
R
Rai
Wendy B
WB
Young
Brian
B
Schultz
James
J
Janc
D015949:Factor IXa / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D011720:Pyrazoles / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*
D011720:Pyrazoles; D015842:Serine Proteinase Inhibitors; D015949:Factor IXa