Regulation of cell adhesion by protein-tyrosine phosphatases: II. Cell-cell adhesion.
Cell-cell adhesion is critical to the development and maintenance of multicellular organisms. The stability of many adhesions is regulated by protein tyrosine phosphorylation of cell adhesion molecules and their associated components, with high levels of phosphorylation promoting disassembly. The level of tyrosine phosphorylation reflects the balance between protein-tyrosine kinase and protein-tyrosine phosphatase activity. Many protein-tyrosine phosphatases associate with the cadherin-catenin complex, directly regulating the phosphorylation of these proteins, thereby affecting their interactions and the integrity of cell-cell junctions. Tyrosine phosphatases can also affect cell-cell adhesions indirectly by regulating the signaling pathways that control the activities of Rho family G proteins. In addition, receptor-type tyrosine phosphatases can mediate outside-in signaling through both ligand binding and dimerization of their extracellular domains. This review will discuss the role of protein-tyrosine phosphatases in cell-cell interactions, with an emphasis on cadherin-mediated adhesions.
Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
Jennifer L
JL
Sallee
Erika S
ES
Wittchen
Keith
K
Burridge
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D051177:Catenins / Q000378:metabolism; D002448:Cell Adhesion; D002450:Cell Communication; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008954:Models, Biological; D017027:Protein Tyrosine Phosphatases / Q000502:physiology*; D014443:Tyrosine / Q000378:metabolism
D015820:Cadherins; D051177:Catenins; D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases