Mass spectrometry of RNA.
A complex population of non-coding RNAs is present in higher organisms. These RNAs have a multitude of functions and execute control over gene expression through various, often poorly understood, mechanisms. At present, the identification and analysis of functional regulatory RNAs and disparate ribonucleoprotein complexes remain an experimental challenge for biologists. They require specially designed approaches and techniques in genomics and RNA biochemistry. Developments in technologies based on mass spectrometry could offer sensitive and efficient solutions to analysis of the sequence, structure, modification and composition of RNA.
Central Proteomics Facility, Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK.
Benjamin
B
Thomas
Alexandre V
AV
Akoulitchev
D000818:Animals; D001483:Base Sequence; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012323:RNA Processing, Post-Transcriptional
D012313:RNA