Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.
Studies in transgenic and knockout mice have made a major contribution to our current understanding of the physiological functions of the NF-kappaB signalling cascade. The generation and analysis of mice with targeted modifications of individual components of the NF-kappaB pathway tremendously advanced our knowledge of the roles of the NF-kappaB proteins themselves, and also of the many activators and negative regulators of NF-kappaB. These studies have highlighted the complexity of the NF-kappaB system, by revealing the multiple interactions, redundancies, but also diverse functions, performed by the different molecules participating in the regulation of NF-kappaB signalling. Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer.
Pasparakis
M
M
European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini 32, Monterotondo-Scalo, Rome 00016, Italy. pasparakis@embl-monterotondo.it
Luedde
T
T
Schmidt-Supprian
M
M
D000818:Animals; D016678:Genome; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout / Q000378:metabolism*; D008822:Mice, Transgenic / Q000378:metabolism*; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism; D015533:Transcriptional Activation
D016328:NF-kappa B