Sub-chronic administration of diphenyl diselenide potentiates cadmium-induced testicular damage in mice.
Sub-chronic cadmium (Cd) exposure causes testicular damage in mice. The mode of action may involve oxidative stress and especially lipid peroxidation. The present study has monitored the pathogenesis of testicular damage during sub-chronic Cd exposure and has evaluated the potential protective effect of antioxidant therapy with diphenyl diselenide (PhSe)(2). Male mice were dosed with 2.5 mg/kg CdCl(2) (2.5 mg/kg) with or without (PhSe)(2) (5 micromol/kg) at 30 min post-exposure using a model of five weekly subcutaneous injections. Histological evaluation of the testis was performed across a 4 week test period. Animals exposed to CdCl(2) and CdCl(2) plus (PhSe)(2) displayed a reduction in body weight gain and testicular weight. Progressive damage and histolopathological changes in the testis were not remedied with, but rather were potentiated by, (PhSe)(2) therapy. We conclude that (PhSe)(2) enhances testicular injury in an animal model for sub-chronic Cd exposure mice.
Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105-900, RS, Brazil.
Francielli W
FW
Santos
Dominguita L
DL
Graça
Gilson
G
Zeni
João B T
JB
Rocha
Simone N
SN
Weis
Alexandre M
AM
Favero
Cristina W
CW
Nogueira
D000818:Animals; D000975:Antioxidants / Q000633:toxicity*; D001555:Benzene Derivatives / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D019256:Cadmium Chloride / Q000633:toxicity*; D004357:Drug Synergism; D008297:Male; D051379:Mice; D016566:Organoselenium Compounds / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D000975:Antioxidants; D001555:Benzene Derivatives; D016566:Organoselenium Compounds; C061132:diphenyldiselenide; D019256:Cadmium Chloride