Fungal metabolite analysis in genomics and phenomics.
Metabolomics consists of strategies to quantitatively identify cellular metabolites and to understand how trafficking of these biochemical messengers through the metabolic network influences phenotype. The application of metabolomics to fungi has been strongly pursued because these organisms are widely used for the production of chemicals, are well known for their diverse metabolic landscape and serve as excellent eukaryotic model organisms for studying metabolism and systems biology. Within the context of fungal systems, recent progress has been made in the development of analytical tools and mathematical strategies used in metabolite analysis that have enhanced our ability to crack the code underpinning the cellular inventory, regulatory schemes and communication mechanisms that dictate cellular function. Metabolomics has played a key role in functional genomics and strain classification.
Jewett
Michael C
MC
Center for Microbial Biotechnology, BioCentrum-DTU, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
Hofmann
Gerald
G
Nielsen
Jens
J
D005658:Fungi / Q000235:genetics* / Q000378:metabolism*; D016681:Genome, Fungal; D023281:Genomics / Q000379:methods / Q000639:trends; D010641:Phenotype