The rational design of an AIDS vaccine.
The extraordinary genetic diversity and immune evasion of human immunodeficiency virus (HIV) pose significant challenges for vaccine development. AIDS vaccine design requires a scientifically driven, rational approach that encompasses the latest advances in viral molecular genetics, structural biology, and immunology.
Douek
Daniel C
DC
Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Building 40, MSC-3005, 40 Convent Drive, Bethesda, MD 20892, USA.
Kwong
Peter D
PD
Nabel
Gary J
GJ
D016915:AIDS Vaccines / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D000914:Antibodies, Viral / Q000096:biosynthesis; D002986:Clinical Trials as Topic; D005544:Forecasting; D014644:Genetic Variation; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008285:Major Histocompatibility Complex; D008961:Models, Structural; D013678:Technology, Pharmaceutical; D014764:Viral Proteins / Q000276:immunology
D016915:AIDS Vaccines; D000914:Antibodies, Viral; D014764:Viral Proteins