Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer.
In this study, the combined methylation status of p16, p14, HLTF, CDH13 and RUNX3 was examined in 59 resected primary colorectal cancers using methylation-specific PCR and the methylation status was correlated with the clinicopathological features of the affected patients. A significant difference was found in lymph node metastasis (p = 0.0359) on comparing the methylation status in colorectal cancers with lymph node metastasis to those without. There was also a significant gender difference (p = 0.0248) when the methylation status was compared. Colorectal cancer without lymph node metastasis frequently exhibited aberrant methylation of the p16, p14, HLTF, CDH13 and RUNX3 genes.
Hibi
Kenji
K
Department of Surgery, Seirei Hospital, 56 Kawanayama-machi, Showa-ku, Nagoya 466-8633, Japan. khibi@med.nagoya-u.ac.jp
Nakao
Akimasa
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics; D019175:DNA Methylation; D005260:Female; D019942:Genes, p16; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D025803:Tumor Suppressor Protein p14ARF / Q000235:genetics
D015820:Cadherins; D050677:Core Binding Factor Alpha 3 Subunit; C099972:H-cadherin; C493729:Runx3 protein, human; D025803:Tumor Suppressor Protein p14ARF