Practical thiol surrogates and protective groups for arylthiols for Suzuki-Miyaura conditions.
We have developed practical thiol surrogates and arylthiol protective groups for the Suzuki-Miyaura reaction. 2-Ethylhexyl-3-mercaptopropionate and 4-(2'-mercaptoethyl)pyridine were shown to be not only good thiol surrogates but also good protective groups for thiol. We have demonstrated toleration of these protective groups under aqueous Suzuki-Miyaura conditions.
Process Research, Process R&D, Banyu Pharmaceutical Co. Ltd., 9-1, Kamimutsuna 3-chome, Okazaki, Aichi 444-0858, Japan. takahiro_itoh@merck.com
Takahiro
T
Itoh
Toshiaki
T
Mase
D015097:3-Mercaptopropionic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
C516083:2-ethylhexyl-3-mercaptopropionic acid; C516084:4-(2'-mercaptoethyl)pyridine; D011725:Pyridines; D013438:Sulfhydryl Compounds; D015097:3-Mercaptopropionic Acid