Bacterial genomics and pathogen evolution.
The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results. Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date.
Department of Microbiology & Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
David M
DM
Raskin
Rekha
R
Seshadri
Stefan U
SU
Pukatzki
John J
JJ
Mekalanos
D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity; D019295:Computational Biology; D019143:Evolution, Molecular; D014644:Genetic Variation; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods*; D006801:Humans; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics / Q000379:methods; D017421:Sequence Analysis; D014774:Virulence / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics*
D037521:Virulence Factors