Baylis-Hillman adducts with molluscicidal activity against Biomphalaria glabrata.
The molluscicidal activities of ten Baylis-Hillman adducts against Biomphalaria glabrata (Say) snails, the intermediate host of schistosomiasis, have been determined. Nine of these compounds showed significant molluscicidal activity against B. glabrata, falling below the threshold of 100 microg ml(-1) set for potential molluscicidal activity by the World Health Organisation. Among these compounds, 3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile had the highest activity, with LC(50) = 6.64 microg ml(-1).
Vasconcellos
Mário Laa
ML
Departamento de Química, Universidade Federal da Paraíba, Campus I, João Pessoa, PB, Brazil. mlaav@quimica.ufpb.br
Silva
Tania Ms
TM
Camara
Celso A
CA
Martins
Rodrigo M
RM
Lacerda
Kelly M
KM
Lopes
Horacimone M
HM
Pereira
Vera Lp
VL
de Souza
Rodrigo Oma
RO
Crespo
Lívia Tc
LT
D000818:Animals; D001592:Benzyl Alcohols / Q000737:chemistry*; D001700:Biomphalaria; D008975:Molluscacides / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*
C510493:3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile; D001592:Benzyl Alcohols; D008975:Molluscacides; D009570:Nitriles