The use of anticancer drugs in antiparasitic chemotherapy.
Many similarities exist between cancer cells and parasites. A potentially lucrative starting point for the discovery of novel drugs to combat parasites is to examine available compounds developed against cancer for antiparasitic properties. Here, we review the use of current and promising anticancer agents for treating major human parasitic diseases.
Bernhard-Nocht-Insitut für Tropenmedizin, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany. mo.klinkert@bni-hamburg.de
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D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D015317:Biogenic Polyamines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D006801:Humans; D010944:Plants / Q000737:chemistry; D061988:Proteasome Inhibitors; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D013107:Sphingolipids / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D015317:Biogenic Polyamines; D061988:Proteasome Inhibitors; D047428:Protein Kinase Inhibitors; D013107:Sphingolipids; D011505:Protein-Tyrosine Kinases