Platelet dysfunction after association with Anaplasma phagocytophilum in vitro.
Granulocytic anaplasmosis is a tick-borne, zoonotic disease caused by an obligate intracellular granulocytotropic bacterium, Anaplasma phagocytophilum. A. phagocytophilum and other Anaplasma and Ehrlichia spp. have been variably implicated with an associated hematologic alteration, platelet dysfunction, that can result in potentially serious clinical sequelae including hemorrhage. The objective of this work was to define an in vitro model to assess alterations in platelet function associated with A. phagocytophilum.
Borjesson
Dori L
DL
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA. borje002@umn.edu
Brazzell
Jennifer L
JL
Feferman
Regina
R
D041081:Anaplasma phagocytophilum / Q000472:pathogenicity*; D001792:Blood Platelets / Q000382:microbiology* / Q000473:pathology*; D002478:Cells, Cultured; D018920:Coculture Techniques; D006801:Humans; D010979:Platelet Function Tests