Neuroproteomics in neurotrauma.
Neurotrauma in the form of traumatic brain injury (TBI) afflicts more Americans annually than Alzheimer's and Parkinson's disease combined, yet few researchers have used neuroproteomics to investigate the underlying complex molecular events that exacerbate TBI. Discussed in this review is the methodology needed to explore the neurotrauma proteome-from the types of samples used to the mass spectrometry identification and quantification techniques available. This neuroproteomics survey presents a framework for large-scale protein research in neurotrauma, as applied for immediate TBI biomarker discovery and the far-reaching systems biology understanding of how the brain responds to trauma. Ultimately, knowledge attained through neuroproteomics could lead to clinical diagnostics and therapeutics to lessen the burden of neurotrauma on society.
Ottens
Andrew K
AK
Center of Neuroproteomics and Biomarkers Research, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. aottens@mbi.ufl.edu
Kobeissy
Firas H
FH
Golden
Erin C
EC
Zhang
Zhiqun
Z
Haskins
William E
WE
Chen
Su-Shing
SS
Hayes
Ronald L
RL
Wang
Kevin K W
KK
Denslow
Nancy D
ND
D000818:Animals; D015415:Biomarkers; D001930:Brain Injuries / Q000134:cerebrospinal fluid / Q000235:genetics / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D005786:Gene Expression Regulation; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000134:cerebrospinal fluid / Q000235:genetics; D009483:Neuropsychological Tests; D009488:Neurosciences; D020543:Proteome; D040901:Proteomics
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D020543:Proteome