[Generalized eczema secondary to combined treatment with peginterferon alfa-2a and ribavirin in a patient with chronic hepatitis from the hepatitis C virus].
Adverse skin effects from interferon (IFN) plus ribavirin combined therapy are relatively frequent, but they are usually local and related to the IFN injection site. However, distant or generalized eczematous reactions secondary to this treatment are rare. The introduction of pegylated interferons may increase the frequency of these skin lesions.
Departamento de Dermatología MQ, Hospital Virgen Macarena, Avda. Dr. Fedriani s/n, 41009 Seville, Spain. aruizdecasas@aedv.es
Andrés
A
Ruiz de Casas
Begoña
B
García-Bravo
Francisco
F
Camacho
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D004359:Drug Therapy, Combination; D004485:Eczema / Q000139:chemically induced*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011994:Recombinant Proteins; D012254:Ribavirin / Q000009:adverse effects*
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a