[The assessment of usefulness of humoral markers estimation in patients with autoimmune thyroid diseases].
Autoimmune thyroid diseases (AITD) constitute a group of the most common disorders caused by autoaggression of the immune system, comprising up to 1.5% of the human population. That is why optimalisation of diagnostics of Hashimoto thyroiditis (ChH) and Graves' disease (ChG) is an important issue. Aim of the study was to assess usefulness of humoral markers estimation: antithyroperoxidase antibodies (anty-TPO), antithyreoglobulin antibodies (anty-TG) and antithyroropin receptor antibodies (anty-TSHR).


METHODS
The study was carried out in 5 groups of subjects: 1/14 patients with GD in euthyreosis on methimazol (Geu) 2/20 patients with hyperthyroid GD (Ghiper) 3/15 patients with ChH in euthyreosis on levothyroxine (Heu) 4/16 patients with hypothyroid ChH (Hhipo) 5/12 healthy volunteers age and sex-matched to group 1-4. The serum levels of anty-TPO and anty-TG were determined by the ELISA kit. Anty-TSHR were measured by the RIA method.


RESULTS
The highest level of anty-TPO were observed in Hhipo group: 2.81 IU/I (1.79-3.22) (p<0.001 vs controls, p<0.05 vs ChH in euthyreosis). Among ChG patients higher values of anty-TPO were found in Ghiper group: 1.87 IU/I (0.68-2.88) (p<0.01 vs controls, p<0.05 vs ChG in euthyreosis). In ChH patients a positive correlation was observed between serum TSH and anty-TPO (R=0.47, p<0.01). In studied groups it was found a positive correlation between anty-TPO and anty-TG. Levels of anty-TG were increased in all studied patients as compared to controls, however there were no significant differences in anty-TG values between the groups. The highest concentration of anty-TSHR were found in Ghiper group: 6.71 (3.92-11.32) (p<0.001 vs controls, p<0.001 vs ChG in euthyreosis). There was a significant difference in anty-TSHR concentration between ChH groups: Hhipo i Heu (p<0.05). There was a negative correlation between serum TSH and anty-TSHR level in ChG patients (R=-0.05, p<0.001).


CONCLUSIONS
In diagnostics of humoral markers in patients with AITD the most valuable in clinical practice is estimation of antithyroperoxidase antibodies serum level in Hashimoto thyroiditis and antithyroropin receptor antibodies serum concentration in Graves' disease.
Klinika Endokrynologii, Diabetologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku. mysjan@poczta.onet.pl
Janusz
J
Myśliwiec
Magdalena
M
Okłota
Agnieszka
A
Nikołajuk
Maria
M
Górska
D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D050031:Hashimoto Disease / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D013956:Antithyroid Agents; D001323:Autoantibodies; D015415:Biomarkers