131I-chTNT radioimmunotherapy of 43 patients with advanced lung cancer.
The treatment of advanced lung cancer remains a major challenge in clinical medicine, justifying an urgent need for new therapeutic approaches. In a rather unique international collaboration, 43 patients with advanced lung cancer were treated using iodine-131-labeled tumor necrosis therapy chimeric antibody (131I-chTNT).


METHODS
Patients were treated either with intravenous (i.v.) infusion (n = 22), intratumoral injection using a computer tomography (CT)-guided catheter (n = 16), or combination i.v. and intratumoral infusion (n = 5). All patients, regardless of route of administration, received 2 doses of 131I-chTNT on days 1 and 14.


RESULTS
The results showed that of those patients receiving i.v. injection alone, 2 achieved partial response (PR) (9%), 16 had stable disease (73%), and 4 progressed (18%). Of those patients receiving intratumoral injection only, 1 had a complete response (CR) (6%), 8 achieved PR (50%), 7 had stable disease (44%), and none (0%) progressed. Finally, of those patients receiving both i.v. and intratumoral administration, 1 had a CR (20%), 1 achieved PR (20%), 2 had stable disease (40%), and 1 (20%) showed progression.


CONCLUSIONS
These promising results demonstrate that sufficient doses of radiolabeled antibody can be safely delivered to tumors to cause significant therapeutic effects in advanced lung cancer.
Yu
Like
L
Nanjing Pulmonary Hospital, Nanjing, China.
Ju
Dian Wen
DW
Chen
Wenping
W
Li
Tian
T
Xu
Zhaoqiang
Z
Jiang
Changying
C
Chen
Shaoliang
S
Tao
Qun
Q
Ye
Dan
D
Hu
Peisheng
P
Khawli
Leslie A
LA
Taylor
Clive R
CR
Epstein
Alan L
AL
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use* / Q000633:toxicity; D008175:Lung Neoplasms / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016499:Radioimmunotherapy / Q000379:methods; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D007457:Iodine Radioisotopes; D014409:Tumor Necrosis Factor-alpha