Comparison of an antifungal agent with a mixture of antifungal, antibiotic and corticosteroid agents for the treatment of Malassezia species otitis in dogs.
Twenty dogs with otitis externa in both ears and numerous Malassezia species yeasts on cytological examination were treated in one ear with a combination product containing clotrimazole, marbofloxacin and dexamethasone, and in the other ear with a topical antifungal containing miconazole. The effects of the treatments were analysed on the basis of the scores for pruritus, erythema and amount of cerumen, and the number of yeasts on cytological smears. There were reductions in the counts of Malassezia species after both treatments, but the combination product gave significantly greater reductions in erythema, cerumen and pruritus.
Bensignor
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Dermatology Referral Service, 6 rue Mare Pavée, 35510 Cesson Sévigné, France.
Grandemange
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D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D003022:Clotrimazole / Q000008:administration & dosage / Q000627:therapeutic use; D003881:Dermatomycoses / Q000188:drug therapy / Q000662:veterinary; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use; D008290:Malassezia / Q000472:pathogenicity*; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use; D010032:Otitis Externa / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D015363:Quinolones / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004338:Drug Combinations; D024841:Fluoroquinolones; D015363:Quinolones; D008825:Miconazole; D003907:Dexamethasone; C080260:marbofloxacin; D003022:Clotrimazole