Caveolin-1 as a potential new therapeutic target in multiple myeloma.
Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.
Podar
Klaus
K
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Jerome Lipper Multiple Myeloma Center, 44 Binney Street, Boston, MA 02115, USA. klaus_podar@dfci.harvard.edu
Anderson
Kenneth C
KC
D000818:Animals; D021941:Caveolae / Q000737:chemistry / Q000502:physiology; D051242:Caveolin 1 / Q000037:antagonists & inhibitors* / Q000502:physiology; D002784:Cholesterol / Q000096:biosynthesis; D016503:Drug Delivery Systems; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000209:etiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D051242:Caveolin 1; D042461:Vascular Endothelial Growth Factor A; D002784:Cholesterol; D019869:Phosphatidylinositol 3-Kinases