Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects.
BACKGROUND
The mechanisms underlying weight loss after Roux-en-Y gastric bypass (RYGBP) are not well understood.


OBJECTIVE
The objective of the study was to assess the changes in active glucagon-like peptide 1 (GLP-1) and total peptide YY (PYY) after RYGBP and examine their relationship with changes in hunger and satiety.


METHODS
This was a prospective study on the changes in active GLP-1, PYY, hunger, and satiety in response to a standardized test meal in nine normal-glucose-tolerant obese subjects [body mass index (BMI) 47.4 +/- 6.1 kg/m(2)] before and 6 wk after RYGBP.


RESULTS
Before surgery, meal ingestion failed to stimulate GLP-1 and PYY secretion. Six weeks after surgery, despite subjects still being markedly obese (BMI 43.6 +/- 7.8 kg/m(2)), the area under the curve(0-120') of GLP-1 and of PYY in response to the standardized test meal were significantly elevated (P < 0.05 and P < 0.01, respectively). These hormonal responses were significantly larger (P < 0.01) than those observed in a group matched for the BMI attained 6 wk after surgery. The 2.9 +/- 1.2- and 1.6 +/- 1.9-fold increase, respectively, in the area under the curve(0-120') of GLP-1 and PYY were accompanied by a significant decrease in fasting (P < 0.05) and postprandial hunger (P = 0.05) and a significant increase in satiety (P < 0.05) after meal intake. Nevertheless, a significant correlation between changes in the hormonal and eating behavior parameters was not found.


CONCLUSIONS
Our data show that RYGBP is associated with an improvement in the active GLP-1 and total PYY response to a liquid-meal intake. Moreover, we provide circumstantial evidence for a potential role of these gastrointestinal hormones on the decreased appetite after RYGBP.
Obesity Unit, Hospital Clínic Universitari, Villarroel 170, 08036 Barcelona, Spain.
Rosa
R
Morínigo
Violeta
V
Moizé
Melina
M
Musri
Antonio M
AM
Lacy
Salvador
S
Navarro
José Luís
JL
Marín
Salvadora
S
Delgado
Roser
R
Casamitjana
Josep
J
Vidal
D000328:Adult; D004435:Eating / Q000502:physiology / Q000523:psychology; D005260:Female; D015390:Gastric Bypass / Q000523:psychology*; D005746:Gastric Emptying / Q000502:physiology; D005772:Gastrointestinal Transit / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D006815:Hunger / Q000502:physiology*; D008297:Male; D009767:Obesity, Morbid / Q000601:surgery*; D019894:Peptide YY / Q000097:blood*; D011446:Prospective Studies; D012528:Satiety Response / Q000502:physiology*
D019894:Peptide YY; D052216:Glucagon-Like Peptide 1