Long-term outcome of breast-conserving therapy for breast cancer.
OBJECTIVE
We present a retrospective analysis of long-term therapeutic results for patients treated in our institution to evaluate the efficacy of breast-conserving therapy (BCT).


METHODS
The study population was 99 patients (102 breasts) with stage 0, I, and II breast cancer who underwent breast conservation therapy between April 1990 and November 1997. The entire breast was irradiated to a median dose of 50 Gy (range, 50-60 Gy) in 25-30 fractions. An additional 10 Gy in five fractions with 6-12 MeV electrons was given to 23 breasts (23%) with positive surgical margins.


RESULTS
The 5-/10-year overall survival, cause-specific survival, relapse-free rate, local recurrence, and regional recurrence rates were 94.6/93.3%, 95.7/94.5%, 88.2/77.5%, 4.2/8.5%, and 2.0/6.3%, respectively. In both uni- and multivariate analyses, age < 40 years was a significant prognostic factor for local recurrence. No severe morbidity was observed.


CONCLUSIONS
The long-term clinical outcome of BCT for early breast carcinoma patients in our department was favorable. Patient age <40 was the most important factor associated with an increased risk of local recurrence in the ipsilateral breast.
Department of Diagnostic Radiology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
Akiko
A
Shimauchi
Kenji
K
Nemoto
Yoshihiro
Y
Ogawa
Yoshihisa
Y
Kakuto
Toru
T
Sakayauchi
Yoshihiro
Y
Takai
Takanori
T
Ishida
Noriaki
N
Ohuchi
Hisashi
H
Hirakawa
Michio
M
Kimura
Takayuki
T
Yamada
Shoki
S
Takahashi
Shogo
S
Yamada
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome