CD14: chaperone or matchmaker?
In this issue of Immunity, describe a physical and functional relationship between Toll-like receptor 3 (TLR3) and the pattern recognition protein CD14. In the presence of CD14, TLR3-mediated signal transduction events are amplified.
University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Robert W
RW
Finberg
Evelyn A
EA
Kurt-Jones
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018832:Molecular Chaperones / Q000502:physiology; D015398:Signal Transduction; D051196:Toll-Like Receptor 3 / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D018950:Lipopolysaccharide Receptors; D018832:Molecular Chaperones; D051196:Toll-Like Receptor 3