Selective ABTS radical-scavenging activity of prenylated flavonoids from Cudrania tricuspidata.
The antioxidative properties of five prenylated flavonoids, including new flavanone (2), from the root bark of Cudrania tricuspidata were examined against the ABTS, DPPH, and hydroxyl radicals. In most of the assays to determine their antioxidative properties, the ABTS activity was strongly correlated with DPPH because both methods are responsible for the same chemical property of hydrogen- or electron-donation to the antioxidant. On the other hand, the prenylated flavonoids (1-5) acted differently with both methods; namely, all the prenylated flavonoids strongly scavenged the ABTS radical (IC(50) < 10 microM), while they were inactive against the DPPH radical (IC(50) > 300 microM). Even though isolated 5,7,2',4',-tetrahydroxy-6,5'-diprenylflavanone (3) showed weak reducing power (746 mV) by cyclic voltammetry when compared to quercetin (394 mV), both had similar ABTS activity (IC(50) < 5 microM).
Division of Applied Life Science (BK21 program), Department of Agricultural Chemistry, Institute of Agriculture & Life Sciences, Gyeongsang National University, Japan.
Byong Won
BW
Lee
Jin Hwan
JH
Lee
Sang Wan
SW
Gal
Yea Hwang
YH
Moon
Ki Hun
KH
Park
D052160:Benzothiazoles; D004578:Electron Spin Resonance Spectroscopy; D005419:Flavonoids / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D017368:Protein Prenylation; D013451:Sulfonic Acids / Q000737:chemistry*
D052160:Benzothiazoles; D005419:Flavonoids; D016166:Free Radical Scavengers; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid