Quantitative liver function tests in donors and recipients of living donor liver transplantation.
The unique ability of the liver to regenerate quickly after resection makes living donor liver transplantation (LDLT) possible. This technique uses the unique ability of the liver to regenerate to full size after partial resection. However, the quality and course of this regeneration process in humans are still widely unexplored. In the present study we investigated the quantitative liver function tests galactose elimination capacity (GEC), indocyanine green half-life (ICG), and lidocaine half-life as markers for the quality of the liver regeneration in the first 3 months after LDLT. In this study, 22 consecutive living liver donors and their corresponding recipients were analyzed at baseline and at 10 and 90 days after LDLT. Six recipients lost their grafts during the study period. We compared donors and recipients at the different time points. After LDLT, GEC decreased (-42.6%) and ICG increased (+50.6%) significantly in donors. ICG and GEC remained significantly altered over 3 months in donors with an improvement between days 10 and 90 (GEC, +59.3%; ICG, -9.1%). ICG and GEC improved significantly in recipients between days 10 and 90 (ICG, -63.7%; GEC, +16.3%). The lidocaine half-life showed no significant changes. The donors had better test results and recovered faster than the recipients. In conclusion, after LDLT the parameters for liver capacity and flow remain altered in donors and recipients despite rapid volume growth.
Jochum
Christoph
C
Department of Gastroenterology and Hepatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany. christoph.jochum@uni-essen.de
Beste
Mechthild
M
Penndorf
Volker
V
Farahani
Marjan Sharifi
MS
Testa
Giuliano
G
Nadalin
Silvio
S
Malago
Massimo
M
Broelsch
Christoph E
CE
Gerken
Guido
G
D000328:Adult; D005260:Female; D005690:Galactose / Q000097:blood; D006207:Half-Life; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008012:Lidocaine / Q000493:pharmacokinetics; D008107:Liver Diseases / Q000145:classification / Q000601:surgery; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000502:physiology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D017211:Treatment Failure; D016896:Treatment Outcome
D008012:Lidocaine; D007208:Indocyanine Green; D005690:Galactose