[Effect of glucocorticoid with traditional Chinese medicine in severe acute aespiratory syndrome (SARS)].
OBJECTIVE
To evaluate the effects of traditional Chinese medicine in 461 cases of severe acute respiratory syndrome(SARS) on glucocorticoid's dosage.


METHODS
By using the polycentric nonrandomized concurrent controled trial and under the condition of glucocorticoid use, the patierts were divided into two groups: the integrated traditional Chinese and western mendicine(ITCWM) and simplicity western mendicine alone(WM). The observation indexes were time in hospital, pneumonia duration, mortality, glucocorticoid's gross dosage, glucocorticoid's average dosage of days and glucocorticoid use time.


RESULTS
In the ITCWM group, average time in hospital was shortened (P = 0.058), pneumonia duration was shortened (P = 0.057), mortality fell (P = -0.001). The median of glucocorticoid' s gross dosage was 1,277.0 mg x d(-1) in the ITCWM group, and that was 1,680.0 mg x d(-1) in the WM group (P = 0.083). The median of glucocorticoid's average dosage of days was 84.40 mg x d(-1) in the ITCWM group, and that was 115.33 mg x d(-1) in the WM group (P = 0.025). According to the analysis of 461 cases divided by stages and different ponderance, within 7 days after illness, in the ITCWM group, the glucocorticoid' s average dosage decreased. In the common type, the dosage in the ITCWM and in the WM was 146.43 mg x d(-1), and 183.64 mg x d(-1), respectively (P = 0.057), in the severe type, that was 137.71 and 177.86 mg x d(-1), respectively (P = 0.001).


CONCLUSIONS
Compared with the group of simplicity western mendicine, in the group of integratived Chinese and western mendicine, time in hospital shorten, pneumonia duration shorten, mortality fall, simultaneity, glucocorticoid's average dosage is decreased. The use of TCM in the forepart of treatment can be capable of decreasing glucocorticoid's dosage.
Liu
Bao-yan
BY
China Academy of Traditional Chinese Medicine, Beijing. liuby@mail.cintcm.ac.cn
He
Li-yun
LY
Liang
Zhi-wei
ZW
Tong
Xin-yuan
XY
Hu
Jing-qing
JQ
Jiao
Qiang
Q
Ni
Qing
Q
Liu
Xi-ming
XM
Xie
Yan-ming
YM
Li
Ping
P
Gao
Fan-zhu
FZ
Wen
Tian-cai
TC
Liu
Wei-min
WM
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D008517:Phytotherapy; D011014:Pneumonia / Q000188:drug therapy; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy* / Q000401:mortality
D004365:Drugs, Chinese Herbal; D008775:Methylprednisolone