title: Remission with ursodeoxycholic acid of type 1 autoimmune hepatitis resistant to azathioprine and steroids.
abstract: Combination therapy with steroids and azathioprine is the reference treatment for autoimmune hepatitis, but potential adverse effects are numerous and intolerance can occur. We report a patient with a well-documented type 1 autoimmune hepatitis intolerant to corticosteroids and azathioprine therapy, in whom eight years of ursodeoxycholic acid monotherapy was associated with biochemical and histological remission.
authors.affiliation: Centre Hépato-Biliaire and UPRES 3541, Hôpital Paul Brousse, Villejuif. jean-charles.duclos-vallee@pbr.ap-hop-paris.fr
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Duclos-Vallée
authors.forename: Vincent
authors.initials: V
authors.lastname: Di Martino
authors.forename: Alain
authors.initials: A
authors.lastname: Cazier
authors.forename: Eric
authors.initials: E
authors.lastname: Ballot
authors.forename: Catherine
authors.initials: C
authors.lastname: Johanet
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Yamamoto
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Emile
authors.forename: Catherine
authors.initials: C
authors.lastname: Guettier
authors.forename: Pierre
authors.initials: P
authors.lastname: Coutarel
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cadranel
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D019693:Hepatitis, Autoimmune / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D002756:Cholagogues and Choleretics; D007166:Immunosuppressive Agents; D014580:Ursodeoxycholic Acid; D001379:Azathioprine