title: [Disappearance of a Philadelphia chromosome-positive clone and appearance of a -negative clone following treatment with imatinib mesylate in acute myelomonocytic leukemia].
abstract: A 63-year-old female was diagnosed as having Philadelphia chromosome-positive acute myelomonocytic leukemia in June 2002. The patient received monotherapy with imatinib mesylate or combination therapy with DCM and idarubicin/cytarabine, both of which failed in attaining disease remission. However, the second imatinib administration plus CAG therapy resulted in disappearance of the Philadelphia chromosome-positive clone and increase of Philadelphia chromosome-negative cells. During a therapy-withholding period due to fungal infection, the Philadelphia chromosome-positive clone expanded and the patient died of cerebral hemorrhage in February 2003. The transient suppression of the Philadelphia chromosome-positive clone may have brought about amplification of the Philadelphia chromosome-negative cells after the secondary imatinib treatment.
authors.affiliation: Department of Hematology, Dokkyo University School of Medicine.
authors.forename: Wataru
authors.initials: W
authors.lastname: Takahashi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Arai
authors.forename: Jiro
authors.initials: J
authors.lastname: Tadokoro
authors.forename: Kengo
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamagata
authors.forename: Kinuko
authors.initials: K
authors.lastname: Mitani
mesh_terms: D001549:Benzamides; D002999:Clone Cells; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy*; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate