[Expression of virus antigens in the cells infected by endotheliotropic or fibroblastotropic human cytomegalovirus strains].
The time course of changes in the expression of viral antigens was studied in the endotheliocytes and fibroblasts infected by the endothelial strain VHL/E or the fibroblastotropic strain AD169. In the VHL/E-infected cell cultures, the number of the cells containing viral matrix protein pp65 was found to be in the range of 20% to 98% while that of the cells containing the major extra-early viral antigen p72 was not more than 10%. In AD169-infected cultures, about the same quantities of cells were stained with antibodies to p72 and pp65. There is new evidence for differences in the molecular bases of function in the endotheliotropic and fibroblastotropic types of human cytomegalovirus.
Riaskina
S S
SS
Boiarkin
A V
AV
Bystrevskaia
V B
VB
D000956:Antigens, Viral / Q000378:metabolism*; D002452:Cell Count; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000276:immunology*; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism*; D012692:Serial Passage; D013045:Species Specificity; D013997:Time Factors; D014763:Viral Matrix Proteins / Q000378:metabolism*
D000956:Antigens, Viral; D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa