title: Prevalence of beta-thalassemia trait in premarital screening in Al-Hassa, Saudi Arabia.
abstract: BACKGROUND
  The Al-Hassa area is one of the regions in Saudi Arabia where hemoglobinopathies are prevalent. The Saudi Ministry Of Heath designed a protocol for premarital testing after the royal decree in December 2003. The protocol was implemented in a February 2004 order. The aim of this study was to determine the prevalence of beta-thalassemia trait among subjects coming for premarital screening in the Al-Hassa area.
  
  
  METHODS
  From February 2004 to November 2004, healthy subjects coming to six marriages consultation centers in the Al-Hassa area underwent routine mandatory tests. Subjects were considered to have beta-thalassemia trait if they had a mean corpuscular volume (MCV) <80 fL and/or a mean corpuscular hemoglobin (MCH) <27 pg and a hemoglobin A2 level >3.2%. Venous blood was taken into an EDTA tube and the complete blood count and red blood cell indices were measured by a Coulter automated cell counter on the same day of hemoglobin collection. Electrophoresis was done on cellulose acetate.
  
  
  RESULTS
  All Saudi participants (n=8918), including 4218 (47.3%) males and 4700 (52.7%) females were screened. The prevalence of beta-thassemia trait with high hemoglobin A2 and microcytic hypochromic anemia was 3.4% (307/8918).
  
  
  CONCLUSIONS
  In countries with a high prevalence of hemoglobinopathies, a premarital screening program is helpful for identification and prevention of high-risk marriages. With a 3.4% prevalence of beta-thalassemia trait in premarital couples, future comprehensive programs are needed to know the actual prevalence of beta-thalassemia in Al-Hassa.
authors.affiliation: Medical Department, King Fahad Hospital, Hofuf Saudi, Arabia. suliman2000ww@yahoo.com
authors.forename: Ahmad
authors.initials: A
authors.lastname: Al-Suliman
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011291:Premarital Examinations; D012529:Saudi Arabia / Q000453:epidemiology; D017086:beta-Thalassemia / Q000453:epidemiology*