title: Arylanthranilodinitriles: a new biaryl class of antileishmanial agents.
abstract: A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20microg/mL concentrations, respectively.
authors.affiliation: Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Fateh V
authors.initials: FV
authors.lastname: Singh
authors.forename: Rit
authors.initials: R
authors.lastname: Vatsyayan
authors.forename: Uma
authors.initials: U
authors.lastname: Roy
authors.forename: Atul
authors.initials: A
authors.lastname: Goel
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D007893:Leishmania donovani / Q000187:drug effects*; D051379:Mice
chemical_list: D000981:Antiprotozoal Agents