Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring.
BACKGROUND
Familial aggregation of hypertension, diabetes and dyslipidemia has been well reported. However, only a few studies have assessed to what extent parental histories were involved in the clustering of these diseases.


METHODS
In 2002, associations between parental histories of hypertension, diabetes and dyslipidemia and the clustering of high blood pressure, hyperglycemia and dyslipidemia in individuals were assessed on the basis of 5010 Japanese men and women aged 33-66 years. Risk factor clusters were defined as those having at least two of the three clinical disorders.


RESULTS
Compared with persons with no parental history of the three diseases, those who had 1, 2 and 3 or more parental histories had risk factor clusters, 1.25 (95% CI: 1.07, 1.47), 1.46 (95% CI: 1.16, 1.84) and 1.41 (95% CI: 0.95, 2.11) times higher, respectively, after adjusting for confounding factors. ORs by 1, 2 and 3 of maternal history were 1.33 (95% CI: 1.12, 1.58), 1.65 (95% CI: 1.16, 2.35) and 1.69 (95% CI: 0.64, 4.42), respectively (trend P < 0.001). However, the number of paternal history was not associated with risk factor clusters.


CONCLUSIONS
We conclude that familial history, particularly maternal history, is an important aid to prevention strategy and public health practice for metabolic disorders.
Wada
Keiko
K
Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Nagoya 466-8550, Japan.
Tamakoshi
Koji
K
Yatsuya
Hiroshi
H
Otsuka
Rei
R
Murata
Chiyoe
C
Zhang
Huiming
H
Takefuji
Seiko
S
Matsushita
Kunihiro
K
Sugiura
Kaichiro
K
Toyoshima
Hideaki
H
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D050171:Dyslipidemias / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D004777:Environment; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D007564:Japan; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010290:Parents; D012307:Risk Factors