title: Bruno: a double turn-off for Oskar.
abstract: In Drosophila, the posterior localization of oskar mRNA and its translational regulation are essential for axis specification and germline formation. Recently in Cell, demonstrated that Bruno inhibits cap-dependent translation of oskar mRNA and uncovered a novel Bruno-dependent assembly of oskar mRNA into multimeric RNP particles, which are inaccessible to the translational machinery. This work provides a novel link between mRNA localization, particle formation, and translational regulation.
authors.affiliation: Wellcome Trust Centre for Cell Biology, Michael Swann Building, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, United Kingdom.
authors.forename: Hille
authors.initials: H
authors.lastname: Tekotte
authors.forename: Ilan
authors.initials: I
authors.lastname: Davis
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000502:physiology*; D020868:Gene Silencing; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C093437:bru1 protein, Drosophila; C091675:osk protein, Drosophila