[Analysis of relationship between injury and disease by cardiac functional indicators in hypertension rat after trauma].
OBJECTIVE
To observe the changes of cardiac functional indicators in spontaneously hypertension rats (SHR) suffered by struck injuries of soft tissues, form which to discuss the significance in relationship between injury and disease.


METHODS
SHRs were divided into four groups according to the degree, and whose thigh was struck with the homemade hit instrument. Then the blood pressure, heart rate as well as serum biochemical indicators (CK, CK-Mb, LDH, Cr, BUN, HBDH and AST) were examined. In addition, the morphological changes of heart, brain and kidney were also observed.


RESULTS
The observe values of heart rate and blood pressure of SHRs seemed have relation to the degree of damage, but there were no statistically significance between different hit degree groups. In terms of serum biochemical indicators, all seven indicators of the hit group had significant difference with that of the control group, and the AST CK, CK-MB levels were difference between the group of different strike degree.


CONCLUSIONS
Struck injuries of soft tissues can result in forepart damage of cardiac muscle. The biochemical indicators reflect the degree of injury, and they could be used as a type of objective enzymology indicators for analysis of the relationship between injury and disease in forensic practice.
Yu
Rong-jun
RJ
Department of Forensic Science, Medical School of Xi'an Jiotong University, Xi'an, 710061 China.
Wang
Zhen-yuan
ZY
Fang
Jun-bang
JB
Xu
Yong-chen
YC
Zhu
Xin-ju
XJ
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006614:Hindlimb / Q000293:injuries*; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000473:pathology; D011897:Random Allocation; D051381:Rats
D015415:Biomarkers; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase