title: Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats.
abstract: Effect of dietary supplementation of two types of rice bran fraction on blood pressure (BP), lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats was studied. Male 4-week-old rats were divided into one group fed the AIN-93M-based control (C) diet and two groups fed diet supplemented with 60 g/kg of Driselase and ethanol fractions (DF and EF, respectively) of rice bran. After 8 weeks feeding, the BP decreased in the DF and EF groups in comparison with the C group (p < 0.01). Plasma ACE inhibitory activity, BUN, BUN/creatinine ratio, albumin, triglyceride, and glucose levels were lower in the DF and EF groups than in the C group (p < 0.01). Plasma nitric oxide and urinary 8-hydroxy-2'-deoxyguanosine levels were lower in the DF and EF groups than in the C group (p < 0.01). Rice bran fractions appear to have a beneficial dietary component that improves hypertension, hyperlipidemia, and hyperglycemia.
authors.affiliation: Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan. ardy@biochem.tohoku.ac.jp
authors.lastname: Ardiansyah
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Koseki
authors.forename: Kousaku
authors.initials: K
authors.lastname: Ohinata
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hashizume
authors.forename: Michio
authors.initials: M
authors.lastname: Komai
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D002392:Catechin / Q000032:analysis; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004032:Diet; D000431:Ethanol; D005656:Fungal Proteins; D005707:Gallic Acid / Q000032:analysis; D006026:Glycoside Hydrolases; D006973:Hypertension / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood / Q000652:urine; D012275:Oryza / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke
chemical_list: D001786:Blood Glucose; D005656:Fungal Proteins; D008055:Lipids; D009569:Nitric Oxide; D000431:Ethanol; D005707:Gallic Acid; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002392:Catechin; D006026:Glycoside Hydrolases; C035212:driselase; D003849:Deoxyguanosine