A case of acute ventricular capture threshold rise associated with flecainide acetate.
Antiarrhythmic agents may increase capture threshold, but this is rarely of clinical significance. Flecainide acetate, a class IC agent, is reported to have a significant effect on the myocardial capture threshold. In this presentation, we report the case of a 72-year-old male, with a previously implanted VVI pacemaker due to sick sinus syndrome, who was treated with flecainide acetate for paroxysmal atrial arrhythmia control. During the fifteenth day of treatment, an abrupt rise in the ventricular capture threshold with ventricular pacing failure was noted. The capture threshold decreased two days after discontinuation of flecainide acetate.
Kang
Tae Soo
TS
Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Gangnam-gu, Seoul 135-720, Korea.
Yoon
Young Won
YW
Park
Sungha
S
Hong
Bum-Kee
BK
Kim
Dongsoo
D
Kwon
Hyuck Moon
HM
Kim
Hyun-Seung
HS
D000200:Action Potentials / Q000187:drug effects*; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001282:Atrial Flutter / Q000188:drug therapy; D004562:Electrocardiography; D005424:Flecainide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D016276:Ventricular Function / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D005424:Flecainide