Rookie snail protein LAPS veteran C/EBP: net transcriptional proceeds for long-term facilitation.
Long-term changes in synaptic plasticity require new protein synthesis. This preview discusses data from Kim et al. (this issues of Neuron) that demonstrate the requirement of a novel, nucleolar protein, LLP (LAPS18-like protein), for the formation of long-term facilitation in Aplysia. LLP binds to and transcriptionally activates C/EBP, thereby promoting the formation of long-term facilitation and behavioral sensitization.
Eckel-Mahan
Kristin L
KL
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
Storm
Daniel R
DR
D000818:Animals; D001048:Aplysia / Q000166:cytology / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology; D022762:CCAAT-Enhancer-Binding Proteins / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008954:Models, Biological; D014157:Transcription Factors / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology
D022762:CCAAT-Enhancer-Binding Proteins; D014157:Transcription Factors