title: A case of acute ventricular capture threshold rise associated with flecainide acetate.
abstract: Antiarrhythmic agents may increase capture threshold, but this is rarely of clinical significance. Flecainide acetate, a class IC agent, is reported to have a significant effect on the myocardial capture threshold. In this presentation, we report the case of a 72-year-old male, with a previously implanted VVI pacemaker due to sick sinus syndrome, who was treated with flecainide acetate for paroxysmal atrial arrhythmia control. During the fifteenth day of treatment, an abrupt rise in the ventricular capture threshold with ventricular pacing failure was noted. The capture threshold decreased two days after discontinuation of flecainide acetate.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Gangnam-gu, Seoul 135-720, Korea.
authors.forename: Tae Soo
authors.initials: TS
authors.lastname: Kang
authors.forename: Young Won
authors.initials: YW
authors.lastname: Yoon
authors.forename: Sungha
authors.initials: S
authors.lastname: Park
authors.forename: Bum-Kee
authors.initials: BK
authors.lastname: Hong
authors.forename: Dongsoo
authors.initials: D
authors.lastname: Kim
authors.forename: Hyuck Moon
authors.initials: HM
authors.lastname: Kwon
authors.forename: Hyun-Seung
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001282:Atrial Flutter / Q000188:drug therapy; D004562:Electrocardiography; D005424:Flecainide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D016276:Ventricular Function / Q000187:drug effects*
chemical_list: D000889:Anti-Arrhythmia Agents; D005424:Flecainide