title: Atypical eosinophilic angiocentric fibrosis on nasal septum.
abstract: Eosinophilic angiocentric fibrosis (EAF) is a rare benign condition of unknown aetiology and is most commonly found in the nasal septum and sinus mucosa. We report a case of EAF and present a review of the available literature. A 51-year-old man with progressive nasal obstruction was referred to our hospital. CT and MRI scans revealed a mass on the nasal septum; this was surgically excised. Histological analysis of the resected tumour showed an inflammatory infiltrate with a predominance of eosinophils present in fibrous matrix and absence of eosinophilic vasculitis and onion skinning. Histologically, it resembled granuloma faciale. However, our case was considered to be an EAF although eosinophilic vasculitis and onion skinning were not observed. This was because a cutaneous lesion was absent and the lesion was limited to the nasal septal mucosa.
authors.affiliation: Department of Otorhinolaryngology, Tondabayashi Hospital, 1-3-36, Koyodai, Tondabayashi, Osaka 584-0082, Japan. n-wata@leto.eonet.ne.jp
authors.forename: Noriko
authors.initials: N
authors.lastname: Watanabe
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Moriwaki
mesh_terms: D004802:Eosinophilia / Q000175:diagnosis* / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology; D015508:Nasal Obstruction / Q000209:etiology; D009300:Nasal Septum / Q000473:pathology*; D009668:Nose Diseases / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed