title: Antioxidant activity of beta-blockers: an effect mediated by scavenging reactive oxygen and nitrogen species?
abstract: The therapeutic effects of beta-blockers are normally explained by their capacity to block the beta-adrenoceptors, however, some of the beneficial cardiovascular effects shown by this group of compounds have already been associated with the antioxidant properties that some of them seem to possess. The beta-blockers atenolol, labetalol, metoprolol, pindolol, propranolol, sotalol, timolol, and carvedilol were tested for their putative scavenging activity for ROS (O(2)(-), H(2)O(2), HO(.), HOCl, and ROO(.)) and RNS ((.)NO and ONOO(-)). Some of the studied compounds are effective ROS and/or RNS scavengers, these effects being possibly useful in preventing oxidative damage verified in hypertension as well as in other cardiovascular diseases that frequently emerge in association with oxidative stress.
authors.affiliation: REQUIMTE, Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Gomes
authors.forename: David
authors.initials: D
authors.lastname: Costa
authors.forename: José L F C
authors.initials: JL
authors.lastname: Lima
authors.forename: Eduarda
authors.initials: E
authors.lastname: Fernandes
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D030421:Peroxynitrous Acid; D026361:Reactive Nitrogen Species / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D000319:Adrenergic beta-Antagonists; D000975:Antioxidants; D016166:Free Radical Scavengers; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D006861:Hydrogen Peroxide