Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients.
BACKGROUND
Cardiovascular disease (CVD) is the major cause of mortality and morbidity of hemodialysis (HD) and peritoneal dialysis (CAPD) patients. We aimed to investigate the cardiovascular risk factors and their correlation with CVD in groups of HD and CAPD patients.


METHODS
Thirty HD patients, 30 CAPD patients and 30 healthy controls were included in the study. Apolipoprotein A-l (apo A-l), apolipoprotein B (apo B), apolipoprotein(a) [Lp(a)] and high-sensitivity CRP (hs-CRP) were measured with a Beckman Coulter nephelometer, and homocysteine (Hcy) was determined with an Agilent HPLC analyzer. Lipid profile was determined with a Synchron LX 20 Pro analyzer.


RESULTS
Hcy levels were 41.9+/-19.4, 41.8+/-38.5 and 9.3+/-3.5 micromol/L; Lp(a) levels were 325+/-315, 431+/-367 and 130+/-97 mg/L; hs-CRP levels were 3.78+/-3.21, 4.34+/-3.39 and 2.07+/-1.67 mg/L; apo A1/apo B ratios were 1.46+/-0.6, 1.36+/-0.5 and 1.80+/-0.59; total cholesterol levels were 3.56+/-0.7, 4.84+/-1.1 and 4.39+/-0.5 mmol/L; triglycerides were 1.44+/-0.5, 1.60+/-0.8 and 0.85+/-0.5 mmol/L in the HD, CAPD and control groups, respectively.


CONCLUSIONS
HD and CAPD patients had higher Hcy, hs-CRP and Lp(a) levels and lower apo A/B ratios than controls. There was no significant difference between the HD and CAPD groups. Hypertension, age and hs-CRP showed a positive correlation with CVD.
Yilmaz
F M
FM
Clinical Biochemistry Laboratory, Ministry of Health, Ankara, Turkey.
Yilmaz
G
G
Duranay
M
M
Parpucu
H
H
Senes
M
M
Tekeli
N
N
Yücel
D
D
D000328:Adult; D000375:Aging; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications* / Q000209:etiology / Q000401:mortality; D016022:Case-Control Studies; D005260:Female; D006710:Homocysteine / Q000097:blood / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D007674:Kidney Diseases / Q000097:blood / Q000150:complications*; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects; D006435:Renal Dialysis / Q000009:adverse effects; D012307:Risk Factors
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D017270:Lipoprotein(a); D006710:Homocysteine; D002097:C-Reactive Protein