Towards a better QALY model.
This paper presents a test of the predictive validity of various classes of QALY models (i.e. linear, power and exponential models). We first estimated TTO utilities for 43 EQ-5D chronic health states and next these states were embedded in nonchronic health profiles. The chronic TTO utilities were then used to predict the responses to TTO questions with nonchronic health profiles. We find that the power QALY model clearly outperforms linear and exponential QALY models. Optimal power coefficient is 0.65. Our results suggest that TTO-based QALY calculations may be biased. This bias can be corrected using a power QALY model.
Abellán-Perpiñán
José-María
JM
Department of Applied Economics, University of Murcia, Spain.
Pinto-Prades
José-Luis
JL
Méndez-Martínez
Ildefonso
I
Badía-Llach
Xabier
X
D006304:Health Status; D006306:Health Surveys; D006801:Humans; D015233:Models, Statistical; D019057:Quality-Adjusted Life Years; D015203:Reproducibility of Results; D013030:Spain