title: Intraductal papilloma with bloody discharge from Montgomery's areolar tubercle examined by ductoscopy from the areola.
abstract: A patient with intraductal papilloma who had abnormal bloody discharge from Montgomery's areolar tubercle underwent mammary ductography, mammary ductoscopy from the tubercle, and microdochectomy.A 43-year-old woman who was being followed-up for left breast cancer noticed bloody discharge from Montgomery's areolar tubercle of the right breast. Because the discharge continued for 2 months, further examinations were conducted. Mammary ductoscopy of Montgomery's areolar tubercle showed a normal internal duct structure. The presence of yellowish superficial lesions suggested intraductal inflammation or superficial hyperplasia of the duct epithelium. Lavage cytology revealed benign papillary lesions. Since the discharge continued and we could not completely exclude malignancy, microdochectomy was performed. Histologically a lactiferous duct was connected to Montgomery's areolar tubercle and an intraductal papilloma was seen in part and considered to have caused the bloody discharge. Bloody discharge from Montgomery's areola tubercles is extremely rare, the present case was our first experience with ductoscopy of Montgomery's areolar tubercle out of 641 cases of mammary ductoscopy performed on patients with bloody nipple discharge from 1998 to 2004. In our case, Montgomery's areolar tubercles were connected to a lactiferous duct. Although there are a few breast carcinomas that cause bloody discharge and eruption of areola, areolar preservation should be performed with the knowledge that disease may also involve the areola through the lactiferous ducts.
authors.affiliation: Breast Pathology Section, Cancer Institute, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Tokyo 135-8550, Japan. drsakai@hsp.md.shinshu-u.ac.jp
authors.forename: Takehiko
authors.initials: T
authors.lastname: Sakai
authors.forename: Masujiro
authors.initials: M
authors.lastname: Makita
authors.forename: Futoshi
authors.initials: F
authors.lastname: Akiyama
authors.forename: Kanou
authors.initials: K
authors.lastname: Uehara
authors.forename: Fujio
authors.initials: F
authors.lastname: Kasumi
authors.forename: Rie
authors.initials: R
authors.lastname: Horii
authors.forename: Goi
authors.initials: G
authors.lastname: Sakamoto
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D005122:Exudates and Transudates / Q000166:cytology* / Q000378:metabolism; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology*; D006801:Humans; D009558:Nipples / Q000378:metabolism / Q000473:pathology; D018300:Papilloma, Intraductal / Q000473:pathology*