Daily urinary interleukin-11 excretion correlated with proteinuria in IgA nephropathy and lupus nephritis.
Interleukin-11 (IL-11) is a multifunctional cytokine with both thrombopoietic and anti-inflammatory effects. In an animal study IL-11 was shown to reduce proteinuria in mice with necrotizing glomerulonephritis. The purpose of this current study is to explore the role of IL-11 in human glomerulonephritis. Subjects of this study were patients with proteinuria (daily urine protein excretion >40 mg/m2 per hour) and underlying pathology of IgA nephropathy (IgAN) (n=20), lupus nephritis (LN) (n=40), and idiopathic nephrotic syndrome (INS) (n=68). Daily urinary IL-11 level was measured by enzyme-linked immunosorbent assay (ELISA). Correlation between urinary IL-11 and urinary protein was determined by Pearson's correlation coefficient. Another five patients with serial data of urinary protein, IL-11 and IL-11 messenger RNA (mRNA) expression in urine sediment are presented. The correlation between urinary IL-11 and daily urinary protein was significant for patients with IgAN (r=0.596, P=0.006) and LN (r=0.630, P<0.001), but not for patients with INS (r=0.030, P=0.812). Serial data revealed the same correlation. Furthermore, the peak of urinary IL-11 mRNA preceded that of urinary IL-11. We conclude that daily urinary IL-11 excretion is correlated with urinary protein loss in nephritis having local T helper (Th)1 predominant immune response, such as IgAN and LN. Local IL-11 production may serve as a counter cytokine against Th1-mediated inflammation.
Chien
Jien-Wen
JW
Department of Pediatrics, Children's Hospital, Changhua Christian Hospital, 135, Nanshsiao Street, Changhua, 500, Taiwan.
Chen
Woan-Ling
WL
Tsui
Yi-Giien
YG
Lee
Min-Chun
MC
Lin
An-Yi
AY
Lin
Ching-Yuang
CY
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000652:urine*; D006801:Humans; D017370:Interleukin-11 / Q000652:urine*; D008181:Lupus Nephritis / Q000150:complications / Q000652:urine*; D008297:Male; D011507:Proteinuria / Q000150:complications / Q000652:urine*
D017370:Interleukin-11