title: Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.
abstract: A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.
authors.affiliation: Bio-Organic Science Division, Korea Research Institute of Chemical Technology, 100 Jang-Dong, Yuseong-Gu, Daejeon 305-343, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Ahn
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kim
authors.forename: Woul Seong
authors.initials: WS
authors.lastname: Park
authors.forename: Sung Yun
authors.initials: SY
authors.lastname: Cho
authors.forename: Jae Du
authors.initials: JD
authors.lastname: Ha
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Kang
authors.forename: Dae Gwin
authors.initials: DG
authors.lastname: Jeong
authors.forename: Suk-Kyeong
authors.initials: SK
authors.lastname: Jung
authors.forename: Sang-Hyeup
authors.initials: SH
authors.lastname: Lee
authors.forename: Hwan Mook
authors.initials: HM
authors.lastname: Kim
authors.forename: Song Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Lee
authors.forename: Seong Eon
authors.initials: SE
authors.lastname: Ryu
authors.forename: Joong-Kwon
authors.initials: JK
authors.lastname: Choi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry; D011485:Protein Binding; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000145:classification / Q000378:metabolism*; D012236:Rhodanine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D004791:Enzyme Inhibitors; D009281:Naphthalenes; C013243:salicylaldehyde; C031721:naphthalene; D012236:Rhodanine; D017027:Protein Tyrosine Phosphatases