title: Examining the relationship between bone mineral density and fracture risk reduction during pharmacologic treatment of osteoporosis.
abstract: Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes the patient to an increased risk for fracture. Elements of bone strength include bone mineralization, architecture, turnover, size, and bone mineral density (BMD). Measurement of BMD is the most readily available, noninvasive method for assessing osteoporotic fracture risk and is used by the World Health Organization for diagnostic purposes. Because low BMD is predictive of increased fracture risk, it was believed that changes in BMD during pharmacologic therapy for osteoporosis would strongly predict observed fracture risk reductions. We examined the relationship between changes in BMD and reduction in fracture risk during pharmacologic therapy in postmenopausal women with osteoporosis. The correlation between BMD increases and fracture risk reduction during treatment is not consistent; larger increases in BMD do not necessarily correlate with greater reductions in fracture risk. Multiple factors, in addition to BMD, appear to contribute to the increased bone strength and decreased fracture risk achieved with approved drug therapies for osteoporosis. Until the exact relationship of these factors is fully understood, clinicians should continue to evaluate drug efficacy for osteoporosis based on the fracture risk reductions from well-designed clinical trials.
authors.affiliation: Rheumatology Center of Mobile, 6701 Airport Boulevard, Suite A101, Mobile, AL 36608, USA.
authors.forename: Gino
authors.initials: G
authors.lastname: Divittorio
authors.forename: Kirk L
authors.initials: KL
authors.lastname: Jackson
authors.forename: Vishala L
authors.initials: VL
authors.lastname: Chindalore
authors.forename: Weston
authors.initials: W
authors.lastname: Welker
authors.forename: J Bryan
authors.initials: JB
authors.lastname: Walker
mesh_terms: D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D018570:Risk Assessment; D016103:Spinal Fractures / Q000453:epidemiology / Q000209:etiology
chemical_list: D050071:Bone Density Conservation Agents