title: Lessons learned from molecular defects in nuclear factor kappaB dependent signaling.
abstract: Nuclear factor (NF) kappaB is a ubiquitously expressed transcription factor that plays critical roles in normal development and inflammation. Characterization of naturally occurring defects in signaling pathways leading to activation of NFkappaB, complemented by mouse knockout models, has demonstrated the vital role of NFkappaB in normal host defense.
authors.affiliation: Division of Immunology, Children's Hospital, Boston and Department of Pediatrics, Harvard Medical School, Karp Family Research Building, One Blackfan Circle, Boston, MA 02115, USA.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: McDonald
authors.forename: Riny
authors.initials: R
authors.lastname: Janssen
authors.forename: Raif
authors.initials: R
authors.lastname: Geha
mesh_terms: D000818:Animals; D004476:Ectodermal Dysplasia / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D051550:I-kappa B Kinase / Q000235:genetics; D020672:I-kappa B Proteins / Q000235:genetics; D007110:Immunity, Active; D007113:Immunity, Innate; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D016328:NF-kappa B / Q000172:deficiency / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D020672:I-kappa B Proteins; D016328:NF-kappa B; D051550:I-kappa B Kinase