title: The role of secretin in the cerebellum.
abstract: There is increasing interest in the role played by secretin in the central nervous system. Recent evidence suggests that this peptide is widely expressed in the brain but some areas, notably the cerebellum, show a prominent expression of the peptide and its specific receptor. In this article we summarize our current understanding of the expression pattern and action of secretin in the cerebellum. We discuss the findings supporting the endogenous release of this peptide from Purkinje neurons and its role as a retrograde messenger modulating GABAergic synaptic transmission via multiple mechanisms. In addition, we would like to propose other possible, but still to be confirmed, functions of secretin in the cerebellum..
authors.affiliation: Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. whyung@cuhk.edu.hk
authors.forename: Wing-Ho
authors.initials: WH
authors.lastname: Yung
authors.forename: Ying-Shing
authors.initials: YS
authors.lastname: Chan
authors.forename: Billy K C
authors.initials: BK
authors.lastname: Chow
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D002526:Cerebellar Diseases / Q000378:metabolism / Q000473:pathology; D002531:Cerebellum / Q000378:metabolism*; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism; D012633:Secretin / Q000502:physiology*
chemical_list: D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; C029937:secretin receptor; D012633:Secretin