On formation of thiohydantoins from amino acids under acylation conditions.
Reactions of glycine, alanine, and phenylalanine with acetic anhydride and ammonium thiocyanate give the 1-acetyl-2-thiohydantoins 2a-c. These results appear to contradict prior literature reports pertaining to this reaction.
Reyes
Samuel
S
Texas A & M University, Chemistry Department, P.O. Box 30012, College Station, Texas 77842, USA.
Burgess
Kevin
K
D000215:Acylation; D000596:Amino Acids / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013867:Thiohydantoins / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D013867:Thiohydantoins