title: Metachronous bilateral pleomorphic adenoma of the parotid gland.
abstract: Bilateral salivary gland tumors are very rare, accounting for 3% of all parotid gland tumors. Although the most common tumor with bilateral development is the Warthin tumor, pleomorphic adenomas (PA) have been diagnosed simultaneously as well, but in a smaller incidence. Because of this, the prevalence, etiology, pathogenesis, and behavior of the PA in this context are poorly understood. We present a case of bilateral metachronous PA affecting the parotid gland in a 63-year-old woman. Clinically, the lesions presented with similar aspects as seen in cases of solitary PA with slow-growing asymptomatic nodule. Both lesions were diagnosed by fine-needle aspiration biopsy at an interval of 2 years between them. A total and superficial parotidectomy for left and right tumors, respectively, was performed. Only on the left side some facial nerve branches were removed that induced partial paralysis in the patient. A review of the pertinent literature is included.
authors.affiliation: Department of Head and Neck Surgery, University Hospital, School of Medicine, Federal University of Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Sindeval José da
authors.initials: SJ
authors.lastname: Silva
authors.forename: Gabriel Tadeu
authors.initials: GT
authors.lastname: Costa Junior
authors.forename: Adalberto Caldeira
authors.initials: AC
authors.lastname: Brant Filho
authors.forename: Paulo Rogério
authors.initials: PR
authors.lastname: Faria
authors.forename: Adriano Mota
authors.initials: AM
authors.lastname: Loyola
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000601:surgery; D005154:Facial Nerve / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010306:Parotid Gland / Q000601:surgery; D010307:Parotid Neoplasms / Q000473:pathology* / Q000601:surgery