Oxidative damage and aging: spotlight on mitochondria.
Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span.
Linford
Nancy J
NJ
Department of Pathology, University of Washington, Seattle, Washington 98195, USA. nantzee@u.washington.edu
Schriner
Samuel E
SE
Rabinovitch
Peter S
PS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D008017:Life Expectancy; D051379:Mice; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*
D000975:Antioxidants; D006861:Hydrogen Peroxide; D002374:Catalase; D010100:Oxygen