title: Deficits in spatial learning and motor coordination in ADAM11-deficient mice.
abstract: BACKGROUND
  ADAM11 is a member of the ADAM gene family and is mainly expressed in the nervous system. It is thought to be an adhesion molecule, since it has a disintegrin-like domain related to cell-cell or cell-matrix interactions. To elucidate the physiological functions of ADAM11, we generated ADAM11-deficient mice by means of gene targeting.
  
  
  RESULTS
  ADAM11-deficient mice were apparently normal, and survived more than one year with no major histological abnormalities in the brain or spinal cord. Because ADAM11 is highly expressed in the hippocampus and cerebellum, we have examined ADAM11 mutant mice for learning using visual and hidden water maze tasks, and their motor coordination using a rotating rod task. Our results showed that their visual water maze task results are normal, but the hidden water maze and rotating rod task skills are impaired in ADAM11-deficient mice.
  
  
  CONCLUSIONS
  Our results indicate that ADAM11 mutation does not affect cell migration and differentiation during development, but affects learning and motor coordination. Thus, ADAM11 might play an important signalling or structural role as a cell adhesion molecule at the synapse, and may thus participate in synaptic regulation underlying behavioural changes.
authors.affiliation: Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. e2-takahashi@hhc.eisai.co.jp
authors.forename: Eiki
authors.initials: E
authors.lastname: Takahashi
authors.forename: Koji
authors.initials: K
authors.lastname: Sagane
authors.forename: Tohru
authors.initials: T
authors.lastname: Oki
authors.forename: Kazuto
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagasu
authors.forename: Junro
authors.initials: J
authors.lastname: Kuromitsu
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D018390:Gene Targeting; D007858:Learning; D018782:Maze Learning; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009048:Motor Skills; D013037:Spatial Behavior
chemical_list: D008565:Membrane Proteins; C107204:ADAM 11 protein, mouse; D051722:ADAM Proteins