[Experience with glucosamine hydrochloride in the treatment of patients with osteoarthrosis].
OBJECTIVE
To study efficacy and tolerance of glucosamine hydrochloride (GH) in osteoarthrosis (OA).


METHODS
GH was given to patients of the study group (n = 30) for 2 months in a dose 1200 mg/day, while diclofenak was administered to the patients from the control group (n = 24) in a dose 100 mg/day. Clinical, laboratory activity of the disease was estimated before the study, after it, 3 and 6 months later. Side effects were also studied. The efficacy of GH therapy was estimated according to the Lequesne's index, pain intensity on vision-analogy scale (VAS), doses of non-steroidal anti-inflammatory drugs during the day.


RESULTS
A decrease in the Lequesne's index and pain by VAS while walking, requirements of NSAIDs in OA patients were revealed. No unfavorable aftereffects of GH were observed.


CONCLUSIONS
GH relieves pain, improves function of the affected joints, reduces necessity in NSAIDs. The effect persists for 3 months. No side effects were registered.
Svetlova
M S
MS
Ignat'ev
V K
VK
D005260:Female; D005500:Follow-Up Studies; D005944:Glucosamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D010147:Pain Measurement; D016059:Range of Motion, Articular / Q000187:drug effects; D016896:Treatment Outcome
D005944:Glucosamine