Pharmacological-induced haptic changes and the accommodative performance in patients with the AT-45 accommodative IOL.
OBJECTIVE
To investigate the accommodative performance of the AT-45 (eyeonics Inc, Aliso Viejo, Calif) using three-dimensional ultrasound biomicroscopy.


METHODS
The AT-45 haptic region was visualized in vivo 1 month after surgery in four patients using an in-house developed three-dimensional ultrasound biomicroscope. Haptic changes, axial shift, and accommodation amplitude were determined under pharmacologically induced accommodation.


RESULTS
The angulation, depending on the accommodation state, could be distinguished and analyzed. In vivo a mean change in haptic angulation of 3.3 +/- 3.3 degrees (range: 0 degrees to 7 degrees) and a mean forward shift of 0.13 +/- 0.08 mm (range: 0.05 to 0.2 mm) were observed for the AT-45 using pharmacologically induced accommodation. A mean accommodative amplitude of 0.44 +/- 0.24 diopters (D) (range: 0.25 to 0.75 D) was found using a Hartinger coincidence refractometer.


CONCLUSIONS
Minimal angulation changes and axial movements of the AT-45 have been demonstrated using pharmacological stimulation and objective measurement methods. The mechanical performance of the AT-45 in these eyes does not appear to provide the range of accommodation necessary for close work.
Stachs
Oliver
O
Eye Clinic of the University of Rostock, Rostock, Germany. oliver.stachs@med.uni-rostock.de
Schneider
Hanka
H
Beck
Ria
R
Guthoff
Rudolf
R
D000065:Accommodation, Ocular / Q000187:drug effects* / Q000502:physiology; D000368:Aged; D003519:Cyclopentolate / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007910:Lenses, Intraocular; D033401:Microscopy, Acoustic; D008875:Middle Aged; D008916:Miotics / Q000008:administration & dosage*; D009184:Mydriatics / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage; D011474:Prosthesis Design; D019591:Pseudophakia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012029:Refraction, Ocular / Q000187:drug effects / Q000502:physiology
D008916:Miotics; D009184:Mydriatics; D009883:Ophthalmic Solutions; D010862:Pilocarpine; D003519:Cyclopentolate