Is there a role for neoadjuvant chemotherapy in the treatment of stage IV serous endometrial carcinoma?
Serous endometrial carcinoma (SEC) is an uncommon variant of endometrial carcinoma that is notorious for its aggressive clinical course. Similar to its ovarian counterpart, it has a propensity for early intraabdominal and lymphatic spread. We present two cases of advanced SEC, who were left with no residual tumor after neoadjuvant chemotherapy. After three courses of chemotherapy, both patients underwent interval debulking surgery, resulting in no residual disease. The documentation of chemosensitivity might enable the clinician to select a subpopulation of patients with widespread SEC that might benefit from interval debulking surgery.
Despierre
E
E
Division of Gynecological Oncology, Department of Obstetrics & Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium.
Moerman
P
P
Vergote
I
I
Amant
F
F
D000231:Adenocarcinoma, Papillary / Q000175:diagnosis / Q000556:secondary / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D017809:Fatal Outcome; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000628:therapy*; D019772:Topotecan / Q000008:administration & dosage
D019772:Topotecan; D004317:Doxorubicin; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin