Small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome: a case report documenting a complete response.
We describe a case of small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome. Sensorimotor neuropathy had developed 3 years earlier, and neurological symptoms had slowly worsened. Small-cell carcinoma of the esophagus was incidentally diagnosed while investigating the cause of the neurological symptoms. A paraneoplastic neurological syndrome was diagnosed on the basis of cancer and exclusion of other known causes of neurological symptoms. The patient was given combination chemoradiotherapy. There was a complete response to three courses of chemoradiotherapy, with no evidence of disease recurrence 6 years after the diagnosis. There was no progression of paraneoplastic neurological symptoms after the complete response.
Shimoda
Takuya
T
Department of Internal Medicine, Kitasato University East Hospital, Sagamihara, Kanagawa 228-8555, Japan. ep-doc@kitasato-u.ac.jp
Koizumi
Wasaburou
W
Tanabe
Satoshi
S
Higuchi
Katuhiko
K
Sasaki
Tohru
T
Nakayama
Norisuke
N
Azuma
Mizutomo
M
Saigenji
Katsunori
K
Katou
Tomoya
T
Ogino
Mieko
M
D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000209:etiology*; D016896:Treatment Outcome