title: Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection.
abstract: OBJECTIVE
  To compare perinatal outcomes in spontaneous twins compared with those conceived by intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  Cases consisted of 274 intracytoplasmic sperm injection twins, controls were 348 naturally conceived twins delivered between 1999 and 2003 in a tertiary hospital.
  
  
  METHODS
  Birth weight, gestational age at birth, cesarean delivery rate, perinatal mortality and morbidity, congenital anomalies, gestational diabetes and pregnancy induced hypertension.
  
  
  RESULTS
  Preterm deliveries (76.6% vs. 64.1% <37 weeks and 19.7% vs. 13.2% <32 weeks) and low birth weight (73% vs. 60.3% <2500 g and 19.7% vs. 12.6% <1500 g) were significantly higher in the ICSI group compared with controls. Gestational diabetes mellitus (8% vs. 2.9%) and cesarean deliveries (95.2% vs. 77.6%) were more common in cases compared with the control group. There was a significantly higher rate of perinatal morbidity (16.4% vs. 7.8%) and mortality (8% vs. 2.6%) in ICSI twins. The incidence of congenital malformations diagnosed at birth was higher in cases (4.4%) compared with controls (0.9%) but the difference was not significant when adjusted for maternal age.
  
  
  CONCLUSIONS
  Perinatal outcomes of twins after ICSI treatment are less optimal than naturally conceived twins.
authors.affiliation: Hacettepe University Department of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey. Bkaramursel@mesa.com.tr
authors.forename: Burcu
authors.initials: B
authors.lastname: Saygan-Karamürsel
authors.forename: Ozlem
authors.initials: O
authors.lastname: Tekşam
authors.forename: Tarik
authors.initials: T
authors.lastname: Aksu
authors.forename: Murat
authors.initials: M
authors.lastname: Yurdakök
authors.forename: Lütfü
authors.initials: L
authors.lastname: Onderoğlu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins