Alkylation reactions of phosphachroman-2,4-diones and 4-hydroxy phosphacoumarins.
Phosphachroman-2,4-dione and 4-alkoxyphosphacoumarin derivatives, phosphonic analogues of chromones and coumarins with potential biological activities, were synthesized in good yields through sequential base-catalyzed intramolecular cyclization of O-alkyl-O'-(2'-methoxycarbonyl phenyl)-(substituted) benzyl phosphonates and alkylation. The synthesis sets the stage for an examination of the biological activities.
Li
Xueshu
X
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Wang
Yitong
Y
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000478:Alkylation; D002839:Chromans / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D002839:Chromans; D003374:Coumarins