title: [Alcohol use disorder: risks in anesthesia and intensive care medicine].
abstract: Approximately 20% of medical and surgical patients in hospital have an alcohol use disorder (AUD). Diagnosis of chronic alcohol abuse is performed by specific medical history, examination and validated tests. Biomarkers are a means of diagnosing chronic alcoholism in sedated, intubated and emergency patients. Chronic alcohol consumption damages the central nervous and cardiovascular system, the liver and the immune system. In medical ICUs more than 50% of liver injuries and chronic pancreatitis are due to chronic alcohol abuse. The alcohol withdrawal syndrome is emerging in 25% of AUD patients in intensive care after reduction of sedative drugs. Long term alcohol abuse also leads to cardiac arrhythmias, dilatative cardiomyopathy and hypotonic circulatory dysregulation. Bleeding complications are two-fold increased during and after surgery. Immune suppression results in an increased incidence of infectious complications like pneumonia, wound infection and urinary tract infection. In particular, septic encephalopathy is often misinterpreted as alcohol withdrawal syndrome. Due to the fact that AUD patients show a two to five-fold higher rate of postoperative complications they require increased attention to avoid latency of treatment and the development of multiple organ failure. Prophylaxis in terms of drug therapy or abstinence intervals and brief intervention strategies can help to prevent or ease some of these complications and can decrease the rate of long-term injuries.
authors.affiliation: Kliniken für Anästhesiologie und operative Intensivmedizin, Campus Charité Mitte und Campus Virchow-Klinikum, Charité--Universitätsmedizin Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Sander
authors.forename: T
authors.initials: T
authors.lastname: Neumann
authors.forename: V
authors.initials: V
authors.lastname: von Dossow
authors.forename: H
authors.initials: H
authors.lastname: Schönfeld
authors.forename: A
authors.initials: A
authors.lastname: Lau
authors.forename: V
authors.initials: V
authors.lastname: Eggers
authors.forename: C
authors.initials: C
authors.lastname: Spies
mesh_terms: D020751:Alcohol-Induced Disorders / Q000453:epidemiology* / Q000517:prevention & control*; D000758:Anesthesia / Q000009:adverse effects*; D015897:Comorbidity; D003422:Critical Care / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors