title: Tisseel to reduce postparotidectomy wound drainage: randomized, prospective, controlled trial.
abstract: BACKGROUND
  Tisseel (Baxter Corp. Ontario, Canada) is a fibrin-based tissue glue that has been widely used to reduce wound drainage, achieve hemostasis, and decrease surgical complications. To date, Tisseel has not been evaluated in a randomized prospective trial for use in parotid surgery.
  
  
  OBJECTIVE
  To determine whether the use of Tisseel in parotidectomy decreases postoperative wound drainage, the duration of percutaneous drainage, the length of hospital stay, and the frequency of complications.
  
  
  METHODS
  Sixty consecutive parotidectomy patients were randomized into two groups: a group treated with 2 cc of Tisseel prior to wound closure and a control group. Postoperative wound drainage was measured for all patients by blinded hospital staff. The duration of percutaneous drainage, duration of hospital stay, and incidence of complications at the 3-week follow-up were assessed.
  
  
  RESULTS
  A statistically significant difference in total drainage volume (p < .02) and frequency of postoperative seroma (p < .05) was demonstrated between patients treated with Tisseel prior to wound closure and the control group.
  
  
  CONCLUSIONS
  The use of Tisseel in parotidectomy patients prior to wound closure significantly decreases total drainage volume and the frequency of postoperative seroma.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery and the Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Mitra
authors.initials: M
authors.lastname: Maharaj
authors.forename: Chris
authors.initials: C
authors.lastname: Diamond
authors.forename: David
authors.initials: D
authors.lastname: Williams
authors.forename: Hadi
authors.initials: H
authors.lastname: Seikaly
authors.forename: Jeff
authors.initials: J
authors.lastname: Harris
mesh_terms: D000328:Adult; D004322:Drainage; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000627:therapeutic use*; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008297:Male; D010306:Parotid Gland / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D049291:Seroma / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics