Rosai-Dorfman disease of the gastrointestinal tract: report of a case and review of the literature.
Rosai-Dorfman disease (RDD) is a rare, acquired disease of unknown etiology that affects primarily children and young adults. It is characterized by a proliferation of distinctive histiocytes in the lymph nodes and/or extranodal sites. Involvement of the gastrointestinal tract is rare. We report a case of RDD in a 60-year-old woman who presented with hematochezia and was found to have RDD of the rectum presenting as a rectal mass. This report highlights the current pathogenetic mechanisms, immunohistochemical markers, and the gastrointestinal manifestations of RDD.
Alatassi
Houda
H
Department of Pathology, University of Louisville Hospital, Louisville, KY 40202, USA.
Ray
Mukunda B
MB
Galandiuk
Susan
S
Sahoo
Sunati
S
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000473:pathology*; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008875:Middle Aged; D012002:Rectal Diseases / Q000175:diagnosis / Q000473:pathology*; D012007:Rectum / Q000737:chemistry / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule