title: Exhaled nitric oxide in asthma: variability, relation to asthma severity, and peripheral blood lymphocyte cytokine expression.
abstract: Exhaled nitric oxide has been used as a means of indirectly measuring the underlying inflammation in asthma. The objectives of the study were to measure exhaled nitric oxide levels in asthma patients and healthy volunteers, to study peripheral blood lymphocyte cytokine expression, and to study the relationship between exhaled nitric oxide and intracellular cytokine expression. Exhaled nitric oxide was elevated in patients with moderate to severe asthma and with treatment decreased in the first week reaching to a near normal level by 4 weeks. Elevated exhaled nitric oxide was associated with decreased IL-4 and IL-13 cytokine expression by CD8 lymphocytes.
authors.affiliation: Division of Allergy & Immunology, Department of Internal Medicine, Texas Tech University, Health Sciences Center, Lubbock, Texas 79430, USA. Goutam.shome@ttuhsc.edu
authors.forename: Goutam P
authors.initials: GP
authors.lastname: Shome
authors.forename: Joel D
authors.initials: JD
authors.lastname: Starnes
authors.forename: Michael
authors.initials: M
authors.lastname: Shearer
authors.forename: Ronald
authors.initials: R
authors.lastname: Kennedy
authors.forename: Anthony
authors.initials: A
authors.lastname: Way
authors.forename: Ahmed
authors.initials: A
authors.lastname: Arif
authors.forename: Sharma
authors.initials: S
authors.lastname: Prabhakar
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood / Q000276:immunology* / Q000378:metabolism*; D045853:Exhalation; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D018793:Interleukin-13 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D015848:Interleukin-5 / Q000096:biosynthesis*; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D018793:Interleukin-13; D015848:Interleukin-5; D015847:Interleukin-4; D009569:Nitric Oxide; D007371:Interferon-gamma