title: Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium.
abstract: The response of cells to DNA damage is critical for maintaining genomic integrity and for preventing cancer development. Current advances in our understanding of the response of cells to DNA double-strand breaks and to stalled DNA replication forks and the relationship of these responses to human disease were discussed at the 52nd Benzon Symposium in Denmark, Copenhagen. Here we review the novel findings that were presented at this Symposium and the current state of the field.
authors.affiliation: Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
authors.forename: Jiri
authors.initials: J
authors.lastname: Lukas
authors.forename: Vilhelm A
authors.initials: VA
authors.lastname: Bohr
authors.forename: Thanos D
authors.initials: TD
authors.lastname: Halazonetis
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D000071877:Checkpoint Kinase 1; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics / Q000502:physiology; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D003718:Denmark; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D011494:Protein Kinases; C576324:ATM protein, human; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D000071877:Checkpoint Kinase 1; D017346:Protein Serine-Threonine Kinases