title: Psychosis in multiple sclerosis associated with left temporal lobe lesions on serial MRI scans.
abstract: There is retrospective evidence of a correlation between psychosis in multiple sclerosis (MS) patients and temporal lobe pathology. A 35-year-old woman with MS presented with psychosis. There was no concurrent history of medication/substance use or family history. Comparison with previous MRI scans showed significant progression of lesions within the periventricular white matter of the left temporal lobe. This case highlights the association of psychosis and MS progression with worsening of left temporal lobe lesions. Prospective studies are required to ascertain the extent to which left temporal lobe lesions are predictive of future psychosis.
authors.affiliation: Department of Psychiatry, University of Manitoba, PZ-203, 771 Bannatyne Avenue, Winnipeg, MB R3E 3N4, Canada. jpreiss@cc.umanitoba.ca
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Reiss
authors.forename: Diana
authors.initials: D
authors.lastname: Sam
authors.forename: Jitender
authors.initials: J
authors.lastname: Sareen
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D003702:Delusions / Q000523:psychology; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D005260:Female; D006212:Hallucinations / Q000523:psychology; D006801:Humans; D000077213:Lamotrigine; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology / Q000523:psychology; D000077152:Olanzapine; D010146:Pain / Q000150:complications / Q000188:drug therapy; D011618:Psychotic Disorders / Q000150:complications* / Q000473:pathology / Q000523:psychology; D018967:Risperidone / Q000627:therapeutic use; D013702:Temporal Lobe / Q000473:pathology*; D014227:Triazines / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D018691:Excitatory Amino Acid Antagonists; D014227:Triazines; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine; D000077213:Lamotrigine