[Experimental study of protective effects of Xuebijing injection on stress-induced organ damage in rabbit].
OBJECTIVE
To investigate the protective effects of the integrated traditional Chinese and western medicine Xuebijing injection on stress-induced organ damage in rabbits.


METHODS
Forty rabbits were randomly divided into four groups: the control group, the model group, the western medicine group, and the Xuebijing group. The stress-induced organ damage model was replicated by soak the rabbits in water, the animals in the western medicine group and Xuebijing group received injection of lytic cocktail and Xuebijing, respectively. The changes in cortisol (Cor), thromboxane A(2) (TXA(2)), endothelin (ET), nitric oxide synthase (NOS) were determined at different time points in all the groups. The pathologic changes of the gastric mucosa, the adrenal gland and the cardiac muscle cell were observed.


RESULTS
The content of Cor increased significantly in model group (P<0.01). The content of Cor decreased in the western medicine group and Xuebijing group, the changes showed no significant difference between two groups (P>0.05). The contents of ET, TXA(2) decreased and NOS increased in Xuebijing group compared with the western medicine group, the differences were significant (all P<0.05). The pathological changes of the gastric mucosa, the adrenal gland and the cardiac myocyte were less marked in Xuebijing group, compared with the western medicine group, the difference was significant (P<0.05).


CONCLUSIONS
Xuebijing has better protective effects on stress-induced organ damage.
Li
Zhi-jun
ZJ
Emergency Medicine Research Institute, Tianjin First Center Hospital, Tianjin 300192, China.
Sun
Yuan-ying
YY
Wu
Yun-liang
YL
Li
Yin-ping
YP
Zhang
Wan-xiang
WX
Liu
Hong-shuan
HS
Wang
Chin-ta
CT
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D006854:Hydrocortisone / Q000097:blood; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology*; D019001:Nitric Oxide Synthase / Q000097:blood; D011817:Rabbits; D011897:Random Allocation; D013312:Stress, Physiological; D013928:Thromboxane A2 / Q000097:blood
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D013928:Thromboxane A2; D019001:Nitric Oxide Synthase; D006854:Hydrocortisone