title: Enhanced expression of peroxiredoxin I and VI correlates with development, recurrence and progression of human bladder cancer.
abstract: OBJECTIVE
  PRDXs are antioxidant enzymes that have an important role in cell differentiation, proliferation and apoptosis. We investigated whether PRDX I and VI expression is related to bladder cancer.
  
  
  METHODS
  PRDX I and VI mRNA levels were examined in 149 tumor specimens in patients with primary bladder cancer, in 19 specimens with corresponding normal-appearing bladder mucosa surrounding cancer and in 18 with normal bladder mucosa using real-time polymerase chain reaction.
  
  
  RESULTS
  PRDX I and VI expression in bladder cancer (0.6644 and 0.1455 pg/ml) was significantly higher than in normal tissue (0.0278 and 0.0542 pg/ml, each p <0.05) and higher than in corresponding normal bladder mucosa surrounding cancer (0.2353 and 0.0304 pg/ml, respectively, each p <0.0005). PRDX I and VI expression was enhanced in patients with no recurrence (0.8148 and 0.2232 pg/ml) and no progression (0.7405 and 0.1716 pg/ml) compared with levels in those with recurrence (0.4314 and 0.0588 pg/ml) and progression (0.4338 and 0.0668 pg/ml, respectively, each p <0.05). PRDX I and VI expression did not correlate with disease-free survival in patients with bladder cancer.
  
  
  CONCLUSIONS
  Enhanced PRDX I and VI expression is strongly associated with bladder cancer development. Moreover, enhanced PRDX I and VI expression is also positively associated with a low rate of bladder cancer recurrence and progression. It might be useful as a marker for assessing the recurrence or progression of human bladder cancer.
authors.affiliation: Department of Urology, Yanbian University Hospital, Yanji, People's Republic of China.
authors.forename: Changyi
authors.initials: C
authors.lastname: Quan
authors.forename: Eun-Jong
authors.initials: EJ
authors.lastname: Cha
authors.forename: Hyung-Lae
authors.initials: HL
authors.lastname: Lee
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Han
authors.forename: Keon Myung
authors.initials: KM
authors.lastname: Lee
authors.forename: Wun-Jae
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000209:etiology* / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000378:metabolism*; D010544:Peroxidases / Q000096:biosynthesis*; D054465:Peroxiredoxin VI; D054464:Peroxiredoxins; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000378:metabolism*
chemical_list: D010544:Peroxidases; C515980:PRDX4 protein, human; D054465:Peroxiredoxin VI; D054464:Peroxiredoxins