Fas gene promoter -670 polymorphism in gynecological cancer.
Single-nucleotide polymorphism at -670 of Fas gene promoter (A/G) was examined in a total of 354 blood samples from normal healthy women and gynecological cancer patients. They consisted of 95 normal, 83 cervical, 108 endometrial, and 68 ovarian cancer cases. Eighty-three patients with cervical cancer had statistically higher frequency of GG genotype and G allele than 95 controls (P= 0.0353 and 0.0278, respectively). There was no significant difference in the genotype or allele prevalence between control subjects and endometrial or ovarian cancer patients. The Fas -670 GG genotype was associated with an increased risk for the development of cervical cancer (OR = 2.56, 95% CI = 1.08-6.10) compared with the AA genotype. The G allele also increased the risk of cervical cancer (OR = 1.60, 95% CI = 1.05-2.43) compared with the A allele. Germ-line polymorphism of Fas gene promoter -670 may be associated with the risk of cervical cancer in a Japanese population.
Ueda
M
M
Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki Osaka, Japan. gyn017@poh.osaka-med.ac.jp
Terai
Y
Y
Kanda
K
K
Kanemura
M
M
Takehara
M
M
Yamaguchi
H
H
Nishiyama
K
K
Yasuda
M
M
Ueki
M
M
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics; D005838:Genotype; D018095:Germ-Line Mutation; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D019014:fas Receptor / Q000235:genetics*
D019014:fas Receptor