[Kinetics and action mechanism of vitamin D3 in the process of lipid and blood plasma oxidation in model system].
Kinetics and mechanism of vitamin D3 action were investigated in the process of initiated oxidation of various modeling systems in comparison with activity of various antioxidants such as: alpha-tocopherol, dibunol, alpha-tocopheryl quinone, ubiquinone Q10, philloquinone and beta-carotene. Vitamin D3 addition increased initial and maximal rates of oxygen consumption. The length of circuits, value of a kinetic parameter k2/square root k6, describing oxidability of system as a whole was also increased. Cholecalciferol concentrations exceeding 7.5 x 10(-6) M inhibited these processes. Increase of conjugated dienes was proportional to vitamin D3 concentration. Vitamin D3 did not influence kinetics of accumulation of TBA-reactive products. These results may be explained by high lability of cholecalciferol, which may represent an additional source of free radicals.
Storozhok
N M
NM
Dariukhina
E N
EN
Tsvetkova
E Iu
EIu
Tsymbal
I N
IN
D000975:Antioxidants / Q000737:chemistry*; D002762:Cholecalciferol / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D007700:Kinetics; D015227:Lipid Peroxidation; D008055:Lipids / Q000737:chemistry*; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010949:Plasma / Q000737:chemistry*
D000975:Antioxidants; D008055:Lipids; D002762:Cholecalciferol