title: Feasibility of the single-bolus strategy for measuring the partition coefficient of Gd-DTPA in patients with myocardial infarction: independence of image delay time and maturity of scar.
abstract: The partition coefficient of Gd-DTPA (lambda) is elevated in infarcted relative to normal myocardium. Although MRI following an infusion of Gd-DTPA allows for the quantification of lambda, infarct imaging is more routinely performed using a bolus. In this study we sought to determine how image delay time and time postinfarction influence the estimation of lambda by the bolus strategy. Both infusion and bolus imaging were performed twice in the same group of patients (N = 9): once at 3-4 weeks and again 6 months after reperfusion therapy for myocardial infarction (MI). Bolus estimates of lambda were compared with those calculated after 60 min infusion, and comparisons were repeated at 6 months. The lambda of infarcted myocardium was significantly greater than that of normal tissue, irrespective of either the technique used or the time postinfarction (P < 0.0001, for each). The concordance (Rc) between bolus and infusion estimates of lambda was >0.83 for all image delays >4 min postinjection, and Rc at 2 min (0.78 +/- 0.04) was significantly less than Rc determined for longer image delay times (P = 0.009). Rc did not change with time postinfarction (P = 0.604). Thus, the bolus strategy can be used to provide estimates of lambda that are stable from 1-6 months postinfarction and independent of image delay time.
authors.affiliation: Imaging Division, Lawson Health Research Institute, London, Ontario, Canada.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Thornhill
authors.forename: Frank S
authors.initials: FS
authors.lastname: Prato
authors.forename: Gerald
authors.initials: G
authors.lastname: Wisenberg
authors.forename: James A
authors.initials: JA
authors.lastname: White
authors.forename: Judith
authors.initials: J
authors.lastname: Nowell
authors.forename: Anya
authors.initials: A
authors.lastname: Sauer
mesh_terms: D000704:Analysis of Variance; D002921:Cicatrix / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage*; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA