title: Toxicity assessment of the antifouling compound zinc pyrithione using early developmental stages of the ascidian Ciona intestinalis.
abstract: This study investigated the toxicity of zinc pyrithione (Zpt) on the early stages of development of the ascidian Ciona intestinalis. Larval morphological abnormalities were studied after the exposure of C. intestinalis embryos at different stages of development. The median effective concentrations (EC50) ranged from 226-590 nM. The larval settlement stage was the most sensitive to Zpt. Toxic effects of Zpt on larval settlement were detected at 9 nM (EC10). The inhibition of C. intestinalis embryonic development was also used to study the loss of toxicity in Zpt solutions exposed to direct sunlight and laboratory UV light. The results showed that the toxicity of Zpt solutions decreased but did not disappear after 4 h exposure to direct sunlight (EC50 = 484 nM) or UV light (EC50 = 453 nM), compared to control Zpt solutions prepared in dark conditions. On the basis of the present data, predicted no effect concentrations of Zpt to C. intestinalis larvae are lower than predicted environmental concentrations of Zpt in certain polluted areas and therefore, may pose a risk to C. intestinalis populations.
authors.affiliation: Department of Marine Ecology, Göteborg University, Kristineberg Marine Research Station, Fiskebäckskil, Sweden. juan.bellas@uvigo.es
authors.forename: Juan
authors.initials: J
authors.lastname: Bellas
mesh_terms: D000818:Animals; D002938:Ciona intestinalis / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development*; D004625:Embryo, Nonmammalian / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects; D007641:Keratolytic Agents / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D009942:Organometallic Compounds / Q000633:toxicity*; D011725:Pyridines / Q000633:toxicity*; D015032:Zinc / Q000633:toxicity
chemical_list: D007641:Keratolytic Agents; D009942:Organometallic Compounds; D011725:Pyridines; D015032:Zinc; C010423:pyrithione zinc