Sulphasalazine-induced DRESS.
Drug rash with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity syndrome. It presents with severe cutaneous eruption, fever, lymphadenopathy, hepatitis, haematological abnormalities with eosinophilia, atypical lymphocytes and may also involve other organs. The multi-organ involvement differentiates this entity from other common drug eruptions. DRESS has been associated with higher morbidity and mortality compared to other adverse drug reactions. Sulphasalazine hypersensitivity is rarely reported and we wish to highlight a case of sulfasalazine-induced DRESS presenting as leukocytoclastic vasculitis, hepatitis and haematological abnormalities in a 49-year-old Indian woman.
Teo
L
L
Division of Dermatology, Changi General Hospital, 2 Simei Street 3, Singapore 529889.
Tan
E
E
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004802:Eosinophilia / Q000139:chemically induced*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012460:Sulfasalazine / Q000009:adverse effects*; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine