title: Genotoxicity and transmission electron microscopy studies of molybdocene dichloride.
abstract: The cytotoxic effects of molybdocene dichloride (Cp(2)MoCl(2)) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp(2)MoCl(2) produced significant genotoxic damage whereby 0.2micronuclei/1000 binucleated cells were induced per muM of Cp(2)MoCl(2). Transmission electron microscopic analysis of thin-sectioned cells treated with Cp(2)MoCl(2) (300microM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.
authors.affiliation: School of Chemistry, The University of Sydney, NSW 2006, Australia.
authors.forename: Kate S
authors.initials: KS
authors.lastname: Campbell
authors.forename: Amalanie J
authors.initials: AJ
authors.lastname: Foster
authors.forename: Carolyn T
authors.initials: CT
authors.lastname: Dillon
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Harding
mesh_terms: D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D005453:Fluorescence; D015162:Micronucleus Tests; D046529:Microscopy, Electron, Transmission; D009152:Mutagenicity Tests; D009942:Organometallic Compounds / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D009942:Organometallic Compounds; C024389:molybdocene dichloride