[Insulin and arterial hypertension: the role of the kidney].
We have demonstrated that insulin stimulates sodium reabsorption in the distal nephron by stimulating the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and that any stimulation of this enzyme (e.g. by EGF, by H2O2 or by exogenous PIP3, added apically) leads to a parallel increase in sodium reabsorption. We therefore suggest that hyperinsulinemia leads to hypertension through increased renal sodium reabsorption in the distal nephron.
Beauwens
R
R
Laboratoire de Physiologie Cellulaire et Moléculaire-Faculté de Médecine de l'ULB.
D001692:Biological Transport; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007328:Insulin / Q000502:physiology*; D007668:Kidney / Q000502:physiology* / Q000503:physiopathology; D009399:Nephrons / Q000502:physiology; D012964:Sodium / Q000378:metabolism
D007328:Insulin; D012964:Sodium