Non-steroidal and steroidal anti-inflammatory drugs vary in their modulation of dendritic cell function in the elicitation phase of allergic contact dermatitis.
The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation phase in a mouse model of allergic contact dermatitis and to evaluate the effects of steroidal and non-steroidal anti-inflammatory drugs (NSAIDs) on DC migration through skin in the elicitation phase of allergic contact dermatitis. Topically and systemically administered acetylsalicylic acid (ASA) did not reduce the inflammatory response. However, systemically administered ASA significantly reduced the DC migration to the draining lymph node. In contrast, topically administered indomethacin reduced the inflammatory response, but had only minor effects on DC migration, whereas diflorasone diacetate reduced both inflammatory reaction and DC migration. Thus, NSAIDs may differ in their inhibitory action in immunological inflammation.
Bäumer
W
W
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany. wolfgang.baeumer@tiho-hannover.de
Krekeler
S
S
DeVries
V C
VC
Niedorf
F
F
Tschernig
T
T
Kietzmann
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001623:Betamethasone / Q000031:analogs & derivatives / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D017449:Dermatitis, Allergic Contact / Q000473:pathology / Q000503:physiopathology*; D015232:Dinoprostone / Q000502:physiology; D005260:Female; D007150:Immunohistochemistry; D007213:Indomethacin / Q000494:pharmacology; D007801:Langerhans Cells / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D000097782:NF-kappaB-Inducing Kinase
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D001623:Betamethasone; D015232:Dinoprostone; D007213:Indomethacin; D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase; C014477:diflorasone