Modeling the statistics of elementary calcium release events.
Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the release of Ca(2+) from endoplasmic reticulum through small clusters of inositol 1,4,5-trisphosphate receptors, are the building blocks for intracellular Ca(2+) signaling. The small number of release channels involved during a Ca(2+) puff renders the puffs stochastic, with distributed amplitudes, durations, and frequency, well characterized experimentally. We present a stochastic model that accurately describes simultaneously the statistical properties of the duration, amplitudes, frequencies, and spatial spread with a single set of parameters.
Ullah
Ghanim
G
Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio 45701, USA. ghanimul@helios.phy.ohiou.edu
Jung
Peter
P
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D053496:Inositol 1,4,5-Trisphosphate Receptors; D015640:Ion Channel Gating / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D015233:Models, Statistical; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013269:Stochastic Processes
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D002118:Calcium