title: Plasma 8-iso-prostaglandin F2alpha, a marker of oxidative stress, is increased in patients with acute myocardial infarction.
abstract: BACKGROUND
  Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F(2alpha) level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction.
  
  
  METHODS
  Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n = 15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13).
  
  
  RESULTS
  Plasma 8-iso-prostaglandin F(2alpha) levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 +/- 73.9 pg/ml) as compared to patients with stable CAD (182.0+75.7 pg/ml) and patients with no significant CAD (118.9 +/- 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level.
  
  
  CONCLUSIONS
  Plasma 8-iso-prostaglandin F(2alpha) levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.
authors.affiliation: The Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
authors.forename: Ahmad A
authors.initials: AA
authors.lastname: Elesber
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Best
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Lennon
authors.forename: Verghese
authors.initials: V
authors.lastname: Mathew
authors.forename: Charanjit S
authors.initials: CS
authors.lastname: Rihal
authors.forename: Lilach O
authors.initials: LO
authors.lastname: Lerman
authors.forename: Amir
authors.initials: A
authors.lastname: Lerman
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood; D015237:Dinoprost / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D015237:Dinoprost