The role of neural activity in cortical axon branching.
Axonal branching is an important process for establishing the final pattern of connections between a neuron and its target cells. Cortical connections between upper-layer cells in the neocortex have provided insights into the cellular mechanisms by which electrical activity regulates neural connectivity, including branch formation. Recent evidence further indicates that spontaneous firing and synaptic transmission contribute to axonal branching of cortical neurons through postsynaptic activation.
Uesaka
Naofumi
N
Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Ruthazer
Edward S
ES
Yamamoto
Nobuhiko
N
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D002454:Cell Differentiation / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D006801:Humans; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D009924:Organ Culture Techniques; D017470:Receptors, Glutamate / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D017470:Receptors, Glutamate