Anti-topoisomerase I antibodies in systemic lupus erythematosus as a marker of severe nephritis.
The authors report nine patients with systemic lupus erythematosus associated with anti-topoisomerase I antibodies (ELISA test) without features of systemic sclerosis. These antibodies were correlated with the disease activity and might be a marker of the severity of the closely related to difusse proliferative glomerulonephritis.
Hamidou
Mohamed A
MA
Department of Internal Medicine, University Hospital Hôtel-Dieu, Place Alexis Ricordeau, 44 035, Nantes, France. mohamed.hamidou@chu-nantes.fr
Audrain
Marie A
MA
Masseau
Agathe
A
Agard
Christian
C
Moreau
Anne
A
D000328:Adult; D000911:Antibodies, Monoclonal / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000276:immunology*; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D004264:DNA Topoisomerases, Type I