Newer therapeutic approaches: gout.
Newer approaches to the treatment of gout have included modifications and further attention to aspects of current therapies, and development of interesting new therapies. Colchicine prophylaxis appears to be needed longer than previously recognized after introduction of a urate-lowering agent. Diet has received attention, though most dietary effects are small. New agents under investigation include pegylated formulations of uricase and a new potent xanthine oxidase inhibitor, febuxostat. Some cardiovascular drugs have been shown to be uricosuric.
Schumacher
H Ralph
HR
Division of Rheumatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA. schumacr@mail.med.upenn.edu
Chen
Lan X
LX
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015210:Arthritis, Gouty / Q000188:drug therapy*; D000069465:Febuxostat; D006801:Humans; D013844:Thiazoles / Q000627:therapeutic use; D014503:Urate Oxidase / Q000627:therapeutic use; D014528:Uricosuric Agents / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D013844:Thiazoles; D014528:Uricosuric Agents; C469709:rasburicase; D000069465:Febuxostat; D014969:Xanthine Oxidase; D014503:Urate Oxidase