Serotonin transporter gene promoter region polymorphism associated with poststroke major depression.
The authors examined variations of serotonin transporter-linked promoter region (5-HTTLPR) functional polymorphism in 26 stroke patients with major depression and in 25 unrelated nondepressed stroke subjects of Caucasian descent. Findings indicate a significant association between 5-HTTLPR short variant genotype and poststroke major depression.
Ramasubbu
Rajamannar
R
Department of Psychiatry and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, T2N 2T9. rramasub@ucalgary.ca
Tobias
Rose
R
Buchan
Alastair M
AM
Bech-Hansen
N Torben
NT
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013223:Statistics as Topic; D020521:Stroke / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins