title: An XML-based system for synthesis of data from disparate databases.
abstract: Diverse data sets have become key building blocks of translational biomedical research. Data types captured and referenced by sophisticated research studies include high throughput genomic and proteomic data, laboratory data, data from imagery, and outcome data. In this paper, the authors present the application of an XML-based data management system to support integration of data from disparate data sources and large data sets. This system facilitates management of XML schemas and on-demand creation and management of XML databases that conform to these schemas. They illustrate the use of this system in an application for genotype-phenotype correlation analyses. This application implements a method of phenotype-genotype correlation based on phylogenetic optimization of large data sets of mouse SNPs and phenotypic data. The application workflow requires the management and integration of genomic information and phenotypic data from external data repositories and from the results of phenotype-genotype correlation analyses. Our implementation supports the process of carrying out a complex workflow that includes large-scale phylogenetic tree optimizations and application of Maddison's concentrated changes test to large phylogenetic tree data sets. The data management system also allows collaborators to share data in a uniform way and supports complex queries that target data sets.
authors.affiliation: Biomedical Informatics Department, Ohio State University, 3184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA. kurc@bmi.osu.edu
authors.forename: Tahsin
authors.initials: T
authors.lastname: Kurc
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Janies
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Johnson
authors.forename: Stephen
authors.initials: S
authors.lastname: Langella
authors.forename: Scott
authors.initials: S
authors.lastname: Oster
authors.forename: Shannon
authors.initials: S
authors.lastname: Hastings
authors.forename: Farhat
authors.initials: F
authors.lastname: Habib
authors.forename: Terry
authors.initials: T
authors.lastname: Camerlengo
authors.forename: David
authors.initials: D
authors.lastname: Ervin
authors.forename: Umit V
authors.initials: UV
authors.lastname: Catalyurek
authors.forename: Joel H
authors.initials: JH
authors.lastname: Saltz
mesh_terms: D000818:Animals; D003327:Coronary Disease / Q000235:genetics; D003628:Database Management Systems; D030541:Databases, Genetic; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016247:Information Storage and Retrieval; D010641:Phenotype; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D011381:Programming Languages; D018511:Systems Integration