title: Prognostic significance of the serum phosphorus level and its relationship with other prognostic factors in multiple myeloma.
abstract: We studied the serum phosphorus (P) level of 110 patients with multiple myeloma (MM) (age range 42-83 years, median 62 years) and evaluated the relationship between that and other prognostic factors. Serum P level significantly correlated with the prognostic factors that are relevant to renal dysfunction: serum creatinine (P<0.00000001), serum beta2-microglobulin (P=0.00000088), serum uric acid (P=0.0000014), and corrected serum calcium (cCa P=0.000067). Although it also correlated with the percentage of plasma cells in bone marrow nucleated cells (BMPC%) and the hemoglobin (Hb) and leukocyte counts, the significance was less than for the other four prognostic factors. Serum creatinine, BMPC%, leukocyte count, serum uric acid, bone lesions, beta2-microglobulin, and serum cCa were all significantly higher and Hb significantly was lower in the MM patients with hyperphosphatemia (serum P>3.8 mg/dl). The survival time was significantly shorter in these patients (P=0.000087). Multivariate analysis (Cox's proportional hazards regression model) showed that the serum P level is a significant negative prognostic factor in MM patients.
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Toho University School of Medicine, 6-11-1, Omori-nishi, Ota-Ku, Tokyo, 143-8541, Japan. mumeda@green.ocn.ne.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Umeda
authors.forename: Shinya
authors.initials: S
authors.lastname: Okuda
authors.forename: Haruka
authors.initials: H
authors.lastname: Izumi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nagase
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sugasawa
authors.forename: Chiaki
authors.initials: C
authors.lastname: Arai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Natori
authors.forename: Masako
authors.initials: M
authors.lastname: Katoh
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Kuraishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001854:Bone Marrow Cells / Q000473:pathology; D003404:Creatinine / Q000097:blood; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology; D007958:Leukocyte Count; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000473:pathology; D010758:Phosphorus / Q000097:blood*; D011379:Prognosis; D016019:Survival Analysis; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D010758:Phosphorus; D003404:Creatinine