Epilepsy and reproductive disorders: the role of the gonadotropin-releasing hormone network.
Individuals with temporal lobe epilepsy have an increased incidence of reproductive dysfunction. The comorbidity may be due to the acute effects of the seizures, the chronic effects of the epilepsy, and/or the use of antiepileptic drugs on the gonadotropin-releasing hormone network and the hypothalamic-pituitary-gonadal axis. This review provides a brief overview of evidence from experimental animal and clinical studies exploring the basis for epilepsy-associated reproductive abnormalities.
Fawley
Jessica A
JA
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA. jessica.fawley@hsc.utah.edu
Pouliot
Wendy A
WA
Dudek
F Edward
FE
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005831:Genital Diseases, Female / Q000209:etiology; D005832:Genital Diseases, Male / Q000209:etiology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007031:Hypothalamus / Q000503:physiopathology*; D008297:Male
D000927:Anticonvulsants; D012739:Gonadal Steroid Hormones; D007987:Gonadotropin-Releasing Hormone