title: 5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.
abstract: Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Skorobogatyi
authors.forename: Alexei V
authors.initials: AV
authors.lastname: Ustinov
authors.forename: Irina A
authors.initials: IA
authors.lastname: Stepanova
authors.forename: Anna A
authors.initials: AA
authors.lastname: Pchelintseva
authors.forename: Anna L
authors.initials: AL
authors.lastname: Petrunina
authors.forename: Valeriya L
authors.initials: VL
authors.lastname: Andronova
authors.forename: Georgi A
authors.initials: GA
authors.lastname: Galegov
authors.forename: Andrei D
authors.initials: AD
authors.lastname: Malakhov
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Korshun
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D013053:Spectrophotometry
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D003857:Deoxyuridine