Simultaneous occurrence of Hodgkin's lymphoma and Kaposi's sarcoma within the same lymph nodes of a non-AIDS patient.
We report a case of simultaneous occurrence of Hodgkin's lymphoma and Kaposi's sarcoma within the same lymph nodes of a 61-year-old woman without human immunodeficiency virus (HIV) infection. Epstein-Barr virus (EBV) was detected in the Hodgkin cells and Reed-Sternberg cells by EBV LMP-1 immunostaining and Epstein-Barr virus encoded early RNA (EBER) in situ hybridization. In contrast, Kaposi's sarcoma cells were positive for human herpes virus 8. This case is documented because the occurrence of 2 independent tumors infected by 2 unrelated viruses within the same lymph nodes of a patient without HIV infection has rarely been observed.
Ngan
Kah-Wai
KW
Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Kuo
Tseng-Tong
TT
D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D015994:Incidence; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis; D016539:Reed-Sternberg Cells / Q000737:chemistry / Q000473:pathology / Q000821:virology; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000473:pathology / Q000821:virology
D012367:RNA, Viral