title: Severe malaria: metabolic complications.
abstract: Metabolic complications of severe malaria are some of the most important and potentially treatable manifestations of this deadly disease. The commonest metabolic complications (lactic acidosis and hypoglycaemia) arise from increased host anaerobic metabolism probably due to a mismatch between tissue oxygen supply and requirement. Optimising treatments for these complications should be guided by detailed understanding of their underlying pathophysiology, and may help to reduce the intolerably high case fatality rate of severe malaria.
authors.affiliation: Division of Cellular and Molecular Medicine, Centre for Infection, St. George's University of London, London SW17 0RE, UK. tim@planche.demon.co.uk
authors.forename: T
authors.initials: T
authors.lastname: Planche
authors.forename: S
authors.initials: S
authors.lastname: Krishna
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use; D000140:Acidosis, Lactic / Q000469:parasitology; D000962:Antimalarials / Q000627:therapeutic use; D003999:Dichloroacetic Acid / Q000627:therapeutic use; D006801:Humans; D007003:Hypoglycemia / Q000469:parasitology; D016778:Malaria, Falciparum / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D000962:Antimalarials; D003999:Dichloroacetic Acid; D000111:Acetylcysteine