title: Strained polycycles by H5C5x free-radical cascades.
abstract: [reaction: see text] An H(5)C(5x)-type free-radical chain reaction selectively generates up to three new bonds and three new stereocenters in one pot. This previously unexploited strategy provides a straightforward route to the tricyclic cyclopenta[c]indene skeleton, present in a wide range of pharmacologically active natural products, and can significantly simplify the synthesis of other strained polycyclic structures by sidestepping protection, deprotection, and functional group interconversion steps.
authors.affiliation: Departamento de Química Organica y Unidad Asociada al CSIC, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
authors.forename: Edelmiro
authors.initials: E
authors.lastname: Moman
authors.forename: Daniel
authors.initials: D
authors.lastname: Nicoletti
authors.forename: Antonio
authors.initials: A
authors.lastname: Mouriño