title: Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks.
abstract: This study assessed striatal dopamine 1 (D1) receptor binding in patients with major depressive disorder and anger attacks (MDD+A) and healthy volunteers. We used positron emission tomography with [(11)C]SCH 23,390 to compare 10 patients with MDD+A to 10 healthy volunteers. [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, USA. ddougherty@partners.org
authors.forename: Darin D
authors.initials: DD
authors.lastname: Dougherty
authors.forename: Ali A
authors.initials: AA
authors.lastname: Bonab
authors.forename: William E
authors.initials: WE
authors.lastname: Ottowitz
authors.forename: Eli
authors.initials: E
authors.lastname: Livni
authors.forename: Nathaniel M
authors.initials: NM
authors.lastname: Alpert
authors.forename: Scott L
authors.initials: SL
authors.lastname: Rauch
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fava
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Fischman
mesh_terms: D000328:Adult; D000374:Aggression / Q000502:physiology; D000786:Anger / Q000502:physiology*; D001552:Benzazepines / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging; D004292:Dominance, Cerebral / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D012016:Reference Values
chemical_list: D001552:Benzazepines; D002250:Carbon Radioisotopes; D017447:Receptors, Dopamine D1; D004298:Dopamine