title: Classification of conformation for sugar amino acid systems using chiroptical spectroscopy.
abstract: A number of structurally related sugar amino acid systems have been examined by chiroptical methods to aid interpretation of their conformational preference. The use of circular dichroism, in addition to NMR and solution IR, has enabled classification of the conformations adopted by sugar amino acid systems as hydrogen-bonded regular, non-hydrogen-bonded regular, and non-hydrogen-bonded irregular. A set of tetrameric SAAs are examined and the effect of change in primary structure related to conformation.
authors.affiliation: Biological Chemistry, Division of Biomedical Sciences, Imperial College, London, United Kingdom. alison.edwards@imperial.ac.uk
authors.forename: Alison A
authors.initials: AA
authors.lastname: Edwards
authors.forename: George W J
authors.initials: GW
authors.lastname: Fleet
authors.forename: George E
authors.initials: GE
authors.lastname: Tranter
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002942:Circular Dichroism; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D000596:Amino Acids; D002241:Carbohydrates