Vaccine Oka varicella-zoster virus genotypes are monomorphic in single vesicles and polymorphic in respiratory tract secretions.
We previously found that, after immunization with vaccine Oka varicella-zoster virus, virus obtained from a single vesicle were monomorphic, and virus obtained from different individuals were heterogeneous. Here we show that virus obtained from the lungs of a patient were a mixture of vaccine Oka variants. We hypothesize that complications after immunization are unlikely to be caused by expansion of a single, biologically more virulent clone of virus that either pre-exists in the vaccine or develops after random mutation of different clones. We hypothesize that some clones are more trophic than others for skin.
Quinlivan
Mark A
MA
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, England.
Gershon
Anne A
AA
Nichols
Richard A
RA
La Russa
Philip
P
Steinberg
Sharon P
SP
Breuer
Judy
J
D002644:Chickenpox / Q000821:virology*; D019433:Chickenpox Vaccine / Q000009:adverse effects / Q000235:genetics* / Q000302:isolation & purification; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D014645:Herpesvirus 3, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012137:Respiratory System / Q000821:virology; D017422:Sequence Analysis, DNA; D014611:Vaccination / Q000009:adverse effects
D019433:Chickenpox Vaccine; D004279:DNA, Viral