title: Echocardiographic characterization of the cardiovascular phenotype in rodent models.
abstract: Echocardiographic techniques are commonly utilized to describe the rodent cardiovascular phenotype. These approaches are contrasted with other in vivo methods and are positioned in the assay selection process by a review of studies from our laboratory and others. Although not conventionally considered a biomarker, the technique has the potential to be exploited as a marker of intentional or unanticipated toxic biological effects in the preclinical development of drugs and chemicals.
authors.affiliation: Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA. bdh6@po.cwru.edu
authors.forename: Brian D
authors.initials: BD
authors.lastname: Hoit
mesh_terms: D000818:Animals; D001681:Biological Assay; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D004195:Disease Models, Animal; D004452:Echocardiography / Q000379:methods*; D051379:Mice; D010641:Phenotype; D051381:Rats; D013045:Species Specificity