[Level of interleukin-12 and interferon gamma in blood serum of children with neoplasms and allergy].
Interleukin-12 (IL-12) shows strong antineoplasm properties.


OBJECTIVE
of the study was to evaluate concentration of IL-2 in children's serum with malignant disease, association cytokines with the presence allergic reaction.


METHODS
We analysed 100 patients with malignant disease, and/or with allergy (NA+/NA-, respectively), 100 children with allergic disease (A). The control group was 48 healthy cases (K). In all cases were performed skin prick-tests. Concentration of total IgE (t-IgE), IL-12 and INFgamma determined by using ELISA method.


RESULTS
T-IgE concentration was to higher in children with allergy disease compared with healthy cases. To low concentration of IL-12 observed in children's group with malignant and allergy disease compared with the other cases ((NA+) = 123,7 pg/ml, (NA-) = 181,7 pg/ ml, (A) = 167,7 pg/ml, (K) = 154,2 pg/ml, Me respectively). Higher point of INFgamma observed in children with malignant and allergic disease compared with groups with malignant disease but without allergic disease, allergic disease and healthy cases (Me = 0,95 pg/ml, Me = 0.0 pg/ml, Me = 0,28 pg/ml, Me = 0,55 pg/ml, respectively).


CONCLUSIONS
Coexistence malignant process and allergy describes the interference of synthesis IL-12 and increase t-IgE thus prevelance of humoral reaction.
Charubczyk
Anna
A
Uniwersytet Medyczny w Lodzi, Klinika Chorób Dzieci.
Kuna
Piotr
P
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D018664:Interleukin-12 / Q000097:blood* / Q000276:immunology; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000276:immunology; D012882:Skin Tests
D018664:Interleukin-12; D007073:Immunoglobulin E; D007371:Interferon-gamma