Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV.
Hof
Fraser
F
Department of Chemistry, University of Victoria, P.O. Box 3065, STN CSC, Victoria, BC, V8W 3V6, Canada.
Schütz
Andri
A
Fäh
Christoph
C
Meyer
Solange
S
Bur
Daniel
D
Liu
Jun
J
Goldberg
Daniel E
DE
Diederich
François
F
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D001665:Binding Sites; D002403:Cathepsins / Q000037:antagonists & inhibitors; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008956:Models, Chemical; D008958:Models, Molecular; D010961:Plasmodium / Q000201:enzymology*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D011485:Protein Binding; D015800:Protozoan Proteins; D013329:Structure-Activity Relationship
D000962:Antimalarials; D011480:Protease Inhibitors; D015800:Protozoan Proteins; D002403:Cathepsins; D016282:Aspartic Acid Endopeptidases; C089643:plasmepsin; C100637:plasmepsin II