title: [Curative vs palliative strategies in locoregional recurrence of gastrointestinal malignancies].
abstract: Locoregional recurrence is a relevant problem in surgical oncology. Intraluminal local relapse only occurs when the primary resection is carried through with inappropriate safety margins. If possible, a second surgical resection with wider margins is the treatment of choice. When the primary resection was appropriately done, extraluminal relapse in the original tumor bed indicates the primary tumor was already in an advanced stage. The indication for a second resection must be considered carefully. A realistic prospect of long-term tumor control exists only when the second resection yields tumor-free margins and is combined with chemo- and radiotherapy. There is usually no curative treatment option for recurrences in the draining lymph node region, the so-called fourth dimension.
authors.affiliation: Chirurgische Klinik Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 München. siewert@nt1.chir.med.tu-muenchen.de
authors.forename: J R
authors.initials: JR
authors.lastname: Siewert
authors.forename: F
authors.initials: F
authors.lastname: Lordick
authors.forename: K
authors.initials: K
authors.lastname: Ott
authors.forename: B L D M
authors.initials: BL
authors.lastname: Brücher
authors.forename: R
authors.initials: R
authors.lastname: Rosenberg
mesh_terms: D003131:Combined Modality Therapy; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008207:Lymphatic Metastasis; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000473:pathology / Q000601:surgery; D010166:Palliative Care; D011379:Prognosis; D012086:Reoperation