Optic neuropathy from metastatic squamous cell carcinoma of the cervix: an unusual CNS presentation.
BACKGROUND
Central nervous system (CNS) metastases from cervical carcinoma are uncommon events. Leptomeningeal involvement from cervical squamous cell carcinoma has not been extensively described.


METHODS
A 43-year-old woman with initial diagnosis of stage IB squamous cervical carcinoma at age 30 was treated with hysterectomy and left salpingo-oophorectomy. She recurred with nodal disease at age 39 and went into a clinical complete remission after chemotherapy and radiation treatment. Three years later, she presented with symptoms of optic neuropathy. Cerebral spinal fluid (CSF) was positive for squamous cells consistent with primary cervical squamous cell carcinoma. No measurable disease was evident outside of the CNS.


CONCLUSIONS
Meningeal carcinomatosis from cervical squamous cell carcinoma involving optic nerves has not been reported. Rapid progression of this patient's CNS metastatic disease suggests this form of metastases may be more aggressive and carry extremely poor prognosis.
Portera
Chia Chiao
CC
Department of Internal Medicine, Sinai Hospital of Baltimore, MD 21215, USA.
Gottesman
Rebecca F
RF
Srodon
Monica
M
Asrari
Fariba
F
Dillon
Michael
M
Armstrong
Deborah K
DK
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D019574:Optic Nerve Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery