title: Quality of life after total mesorectal excision for rectal cancer.
abstract: BACKGROUND
  After total mesorectal excision for rectal cancer, many surgeons try to avoid an abdominoperineal resection (APR) by performing a transanally double stapled low colo-rectal anastomosis (LRA), frequently without a pouch. This policy is mainly based on the assumption that the quality of life after such LRA is higher than after APR. It has been suggested that a better functional outcome and therefore a higher quality of life might be achieved by a colo-anal J-pouch anastomosis (CPA). The aim of this study was to assess quality of life among disease-free survivors after APR, LRA and CPA.
  
  
  METHODS
  The charts of 301 consecutive patients who had undergone surgery for cancer in the middle or lower third of the rectum were analysed. Two hundred four patients were eligible for inclusion. The quality of life among these patients was assessed using one generic (EQ-5D) and two disease-specific questionnaires (EORTC QLQ-C30 and EORTC QLQ-CR38).
  
  
  RESULTS
  The response rate was 82%. The median follow-up was 31 months. Overall, quality of life was good but CPA patients had better quality of life scores than APR and LRA patients. This difference was not only due to the better functional outcome but also to the lower incidence of disturbed micturition and sexual problems in the CPA group.
  
  
  CONCLUSIONS
  The quality of life after colo-anal J-pouch anastomosis is better than after abdominoperineal resection (APR) and low colo-rectal anastomosis (LRA). The quality of life after APR is similar to that after LRA.
authors.affiliation: Colorectal Research Group of the Department of Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: M P
authors.initials: MP
authors.lastname: Gosselink
authors.forename: J J
authors.initials: JJ
authors.lastname: Busschbach
authors.forename: C M
authors.initials: CM
authors.lastname: Dijkhuis
authors.forename: L P
authors.initials: LP
authors.lastname: Stassen
authors.forename: W C
authors.initials: WC
authors.lastname: Hop
authors.forename: W R
authors.initials: WR
authors.lastname: Schouten
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000523:psychology / Q000601:surgery*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome