title: Whole-brain radiotherapy in the management of brain metastasis.
abstract: Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000 Americans annually. The prognosis for these patients is poor, with median survival times measured in months. In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of chemical modifiers and the management and prevention of neurocognitive deficits.
authors.affiliation: University of Wisconsin, Madison, WI 53792, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Khuntia
authors.forename: Paul
authors.initials: P
authors.lastname: Brown
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Minesh P
authors.initials: MP
authors.lastname: Mehta
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D003071:Cognition; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D006801:Humans; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D016634:Radiosurgery
chemical_list: D011838:Radiation-Sensitizing Agents