Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).
Sano
Hiroko
H
Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Noguchi
Tomomi
T
Miyajima
Atsushi
A
Hashimoto
Yuichi
Y
Miyachi
Hiroyuki
H
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014470:Umbilical Cord / Q000187:drug effects
D020533:Angiogenesis Inhibitors; D016861:Cyclooxygenase Inhibitors; D051545:Cyclooxygenase 1