Synthesis of the Trypanosoma cruzi LPPG heptasaccharyl myo-inositol.
Synthesis of the heptasaccharyl myo-inositol found in Trypanosoma cruzi lipopeptidophosphoglycan was accomplished using a convergent assembly of three building blocks. The target compound is the first complete 2-aminoethyl phosphonic acid substituted glycan related to the glycosylphosphatidylinositol anchor family to be synthesized. The order of assembly enables synthesis of phosphoinositol oligosaccharides related to other glycosylinositolphospholipids in Tr. cruzi, the protozoan parasite causing Chagas' disease, which is endemic in South America.
Hederos
Markus
M
IFM Chemistry, Linköping University, SE-581 83 Linköping, Sweden.
Konradsson
Peter
P
D000818:Animals; D002240:Carbohydrate Sequence; D006017:Glycolipids / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry; D014349:Trypanosoma cruzi / Q000737:chemistry / Q000378:metabolism*
D006017:Glycolipids; D007295:Inositol Phosphates; C111513:LPPG glycoinositolphosphoceramide; D011134:Polysaccharides