Hypobaric hypoxia as a tool to study pregnancy-dependent responses at the maternal-fetal interface.
Establishment of proper oxygen and nutrient supply to the fetus is essential for a successful pregnancy. The maternal-fetal interface is the site of vascular modifications, providing a conduit for the delivery of essential nutrients to the developing fetus. Pregnancy-dependent adaptive vascular responses within the uteroplacental compartment can be exaggerated by exposure to a physiological stressor such as hypoxia. A simple procedure for exposing pregnant rats and mice to hypobaric hypoxia is presented.
Ho-Chen
Jennifer K
JK
Institute of Maternal-Fetal Biology, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA.
Ain
Rupasri
R
Alt
Adam R
AR
Wood
John G
JG
Gonzalez
Norberto C
NC
Soares
Michael J
MJ
D000818:Animals; D001774:Blood Chemical Analysis; D005260:Female; D000860:Hypoxia; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D051379:Mice; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley