Vasculitis treatment - new therapeutic approaches.
In childhood, vasculitis carries with it a not inconsequential morbidity and mortality. Current therapy is usually effective in inducing remission, but there is a penalty in terms of significant and serious side effects as well as concerns about long-term maintenance regimens. Additionally, some patients are recalcitrant to treatment and options have, hitherto, been limited in relation to alternative therapy. In view of this, novel therapeutic approaches are being explored that include the better use of long-established agents as well as the utilization of newer immunosuppressive and immunomodulatory strategies. Blockade of circulating mediators and surface receptors as well as lymphocyte depletion and immunoablation are being introduced predominantly in adults but increasingly also in children. With greater understanding of the pathogenetic mechanisms involved in the disease processes it is becoming possible to utilize much more focussed therapy for these serious and life-threatening disorders with, hopefully, a decrease in long-term morbidity and mortality as well as a diminution of drug-induced adverse effects.
Dillon
Michael J
MJ
Nephro-Urology Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. m.dillon@ich.ucl.ac.uk
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000069285:Infliximab; D008212:Lymphocyte Depletion; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010951:Plasma Exchange; D013601:T-Lymphocytes / Q000276:immunology; D014657:Vasculitis / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*
D000911:Antibodies, Monoclonal; D006146:Guanidines; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D000069285:Infliximab; D009173:Mycophenolic Acid; C037258:gusperimus