[The condition of vascular-thrombocyte hemostasis in the elderly with arterial hypertension].
The aim of the study was to analyze the main parameters of vascular-thrombocyte hemostasis in patients with systolo-diastolic and isolated systolic arterial hypertension (SDAH and ISAH) aged over 65 years. The subjects were 201 elderly patients with AH. The study revealed that uncomplicated AH in the elderly was characterized by activation of vascular hemostasis and increase of thrombocyte aggregation ability, manifested by the increase of Willebrand factor level, the presence of spontaneous and irreversible aggregation, coincidence of the first and the second waves of aggregation, and intensification of aggregation in response to "moderate" and "strong" inductors. Unlike ISAH, uncomplicated SDAH in the elderly is characterized by noticeable prevalence of night-peakers in the day profile of arterial pressure, and is accompanied by more pronounced thrombocyte hyperfunction; this difference should be taken into account while administering disaggregation therapy.
Nosov
V P
VP
Borovkov
N N
NN
Bashiukova
O G
OG
D000368:Aged; D001792:Blood Platelets; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D010974:Platelet Aggregation; D014841:von Willebrand Factor / Q000378:metabolism
D014841:von Willebrand Factor