title: Frequency of small bowel polyps in patients with duodenal adenoma but without familial adenomatous polyposis.
abstract: BACKGROUND
  It is uncertain whether patients with duodenal adenomas without familial adenomatous polyposis (FAP) are at greater risk for small bowel neoplasia. We therefore conducted a study to determine the frequency of small bowel polyps in patients with non-papillary duodenal adenomas using capsule endoscopy for small bowel examination.
  
  
  METHODS
  14 patients (8 women, 6 men; mean age 67 +/- 10 years; range: 49 - 77 years) with non-papillary duodenal adenomas without FAP were included. All patients underwent wireless capsule endoscopy. The results were compared with an age- and sex-matched cohort of patients undergoing capsule endoscopy for suspected small bowel disease.
  
  
  RESULTS
  Overall, 15 polyps ranging between 1 and 8 mm in diameter were detected in eight patients of the study group, whereas no polyps could be identified in the control group. Natural excretion of the capsule within 24 hours was always reported and no complications were reported by any of the patients. Other pathological findings were multiple angiodysplasias in two patients of the study group. In the control group capsule endoscopy detected angiodysplasias in 5 patients with the indication obscure gastrointestinal bleeding, and inflammatory lesions in 2 patients with suspected Crohn's disease.
  
  
  CONCLUSIONS
  Based on the results of this prospective study, the frequency of small bowel polyps in patients with duodenal adenomas without familial adenomatous polyposis appears to be increased compared with a control group undergoing capsule endoscopy for other reasons. In none of the patients was the management altered. Follow-up data of these patients will be needed.
authors.affiliation: Department of Medicine C (Gastroenterology), Klinikum der Stadt Ludwighafen, Ludwigshafen am Rhein.
authors.forename: J F
authors.initials: JF
authors.lastname: Riemann
authors.forename: D
authors.initials: D
authors.lastname: Hartmann
authors.forename: D
authors.initials: D
authors.lastname: Schilling
authors.forename: U
authors.initials: U
authors.lastname: Damian
authors.forename: A
authors.initials: A
authors.lastname: Eickhoff
authors.forename: U
authors.initials: U
authors.lastname: Weickert
mesh_terms: D000236:Adenoma / Q000473:pathology*; D011125:Adenomatous Polyposis Coli / Q000151:congenital / Q000453:epidemiology / Q000473:pathology; D000368:Aged; D015897:Comorbidity; D004379:Duodenal Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D007417:Intestinal Polyps / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors