title: HbSC hemoglobinopathy suspected by chest x-ray and red blood cell morphology.
abstract: Thorax scan was performed for elucidation of a pulmonary problem in a Nigerian immigrant. The aspect of the vertebrae suggested sickle cell disease, of course without specification of the genotype. Routine hematological tests seemed compatible with an HbSC disease, showing typical laboratory features, namely a significant proportion of hyperchromic RBC, corresponding to secondary, non hereditary spherocytosis, presence of numerous target cells and occasional HbC crystals on Pappenheim stained blood films. The diagnosis of HbSC disease was confirmed by HPLC, iso-electric focusing and citrate agar electrophoresis of hemoglobin and by reverse phase HPLC of globin-chains. This case illustrates the importance of screening for hemoglobin anomalies as it is performed in a multiethnic country such as the Grand Duchy of Luxembourg
authors.affiliation: Laboratoires réunis, L6101 Junglinster, Grand Duchy of Luxembourg.
authors.forename: J
authors.initials: J
authors.lastname: Thoma
authors.forename: D
authors.initials: D
authors.lastname: Kutter
authors.forename: S
authors.initials: S
authors.lastname: Casel
authors.forename: P
authors.initials: P
authors.lastname: Rosoux
authors.forename: C
authors.initials: C
authors.lastname: Braas
authors.forename: F
authors.initials: F
authors.lastname: Ries
authors.forename: P
authors.initials: P
authors.lastname: Groff
authors.forename: G
authors.initials: G
authors.lastname: Kalmes
authors.forename: B
authors.initials: B
authors.lastname: Golinska
mesh_terms: D000328:Adult; D004912:Erythrocytes / Q000473:pathology*; D006450:Hemoglobin SC Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008297:Male; D011859:Radiography; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging*