Bone cell proliferation on carbon nanotubes.
We explored the use of carbon nanotubes (CNTs) as suitable scaffold materials for osteoblast proliferation and bone formation. With the aim of controlling cell growth, osteosarcoma ROS 17/2.8 cells were cultured on chemically modified single-walled (SW) and multiwalled (MW) CNTs. CNTs carrying neutral electric charge sustained the highest cell growth and production of plate-shaped crystals. There was a dramatic change in cell morphology in osteoblasts cultured on MWNTs, which correlated with changes in plasma membrane functions.
Zanello
Laura P
LP
Department of Biochemistry, University of California, Riverside, 92521, USA. Laura.zanello@ucr.edu
Zhao
Bin
B
Hu
Hui
H
Haddon
Robert C
RC
D000818:Animals; D001842:Bone and Bones / Q000166:cytology* / Q000502:physiology; D015220:Calcium Channels / Q000378:metabolism; D002460:Cell Line; D049109:Cell Proliferation; D018118:Chloride Channels / Q000378:metabolism; D004594:Electrophysiology; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D051381:Rats
D015220:Calcium Channels; D018118:Chloride Channels; D037742:Nanotubes, Carbon