title: A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1.
abstract: An HIV-vaccine consisting of a DNA prime, recombinant fowlpox virus (rFPV) boost was evaluated in a double-blind placebo controlled trial. One milligram of pHIS-HIV-B expressing mutated gag, pol, env, vpu, tat and rev was administered at weeks 0 and 4 boosted by 5 x 10(7) pfu rFPV-HIV-B expressing gag/pol at week 8. The vaccine regimen was safe, but there was no difference between vaccine (n = 18) and placebo recipients (n = 6) for Gag or Pol-specific T-cell immune responses at week 9.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Kelleher
authors.forename: Rebekah L
authors.initials: RL
authors.lastname: Puls
authors.forename: Mark
authors.initials: M
authors.lastname: Bebbington
authors.forename: David
authors.initials: D
authors.lastname: Boyle
authors.forename: Rosemary
authors.initials: R
authors.lastname: Ffrench
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kent
authors.forename: Sue
authors.initials: S
authors.lastname: Kippax
authors.forename: Damian F J
authors.initials: DF
authors.lastname: Purcell
authors.forename: Scott
authors.initials: S
authors.lastname: Thomson
authors.forename: Handan
authors.initials: H
authors.lastname: Wand
authors.forename: David A
authors.initials: DA
authors.lastname: Cooper
authors.forename: Sean
authors.initials: S
authors.lastname: Emery
mesh_terms: D016915:AIDS Vaccines / Q000009:adverse effects / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005587:Fowlpox virus / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D019444:Vaccines, DNA / Q000009:adverse effects / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D019444:Vaccines, DNA; D007371:Interferon-gamma