Congenital corectopia (eccentric pupils): a marker for chromosomal and central nervous system abnormality.
We present a case series of five children with congenital corectopia without any associated ocular cause: three had chromosomal abnormalities; one a probable prenatal diplegia, and one bilateral perisylvian dysplasia with vermian and midbrain hypoplasia. Bilateral congenital corectopia is an ophthalmic sign that merits chromosomal analysis and neuro-developmental assessment.
Ennis
Julia
J
Departments of Ophthalmology and Neurology, Sheffield Children's NHS Trust, Sheffield, UK. julia.ennis@sch.nhs.uk
Burke
John
J
Baxter
Peter
P
D001921:Brain / Q000002:abnormalities; D002490:Central Nervous System / Q000002:abnormalities*; D002547:Cerebral Palsy / Q000235:genetics; D002675:Child, Preschool; D002875:Chromosomes / Q000235:genetics*; D002658:Developmental Disabilities / Q000150:complications / Q000235:genetics; D004314:Down Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011681:Pupil Disorders / Q000151:congenital* / Q000235:genetics*