Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats.
To investigate the effects of fermented brown rice (FBRA) on the development of hereditary hepatitis in Long-Evans Cinnamon (LEC) rats, we compared the incidence and grades of acute hepatitis among rats fed 5% and 10% FBRA in the conventional diet and the conventional diet alone. Both the 5% and 10% FBRA-supplemented diets indicated a tendency to prevent the development of hepatitis, and the significant effect of 10% FBRA was observed until 16-17 weeks of age in the accumulated incidence and survival ratio compared with the unsupplemented conventional diet, although no significant difference was observed between 5% and 10% FBRA-supplemented diets. At the age of 12 weeks, which is just before the rats develop hepatitis, serum copper levels in rats fed either of the test diets were similar to those in rats fed the conventional diet. Furthermore, the copper concentration in liver tissue at 12 weeks of age was not changed by the test diet. These results suggest that FBRA has preventive effects on the development of hepatitis in LEC rats and may play an important role in protecting the liver against the free radicals induced by copper accumulation in the liver.
Shibata
Toshiyuki
T
Department of Oral and Maxillofacial Sciences, Gifu University, Graduated School of Medicine, Gifu 501-1194, Japan. shibat@cc.gifu-u.ac.jp
Nagayasu
Hiroki
H
Kitajo
Hiroyuki
H
Arisue
Makoto
M
Yamashita
Tomomi
T
Hatakeyama
Daijiro
D
Iwasaki
Teruaki
T
Kobayashi
Hiroshi
H
D000208:Acute Disease; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D005285:Fermentation; D006505:Hepatitis / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D012275:Oryza; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D020332:Rats, Inbred LEC; D015996:Survival Rate; D013997:Time Factors
D028321:Plant Preparations