title: Identification of degradation products from aqueous carboplatin injection samples by electrospray mass spectrometry.
abstract: Four different carboplatin injection samples in water ( approximately 10mg/ml) stored at room temperature were investigated for degradation products by electrospray liquid chromatography-mass spectrometry (ESI/LC-MS). A mass spectrometer compatible mobile phase system with 0.02% formic acid and methanol was used to resolve the impurities. Possible chemical structures of the unknown impurities and its degradation mechanism were proposed based on its experimental results and literature findings.
authors.affiliation: Mass Spectrometry Lab, Dabur Research Foundation, 22 Site IV, Sahibabad, UP 201010, India. vivekanandan@dabur.com
authors.forename: Kannan
authors.initials: K
authors.lastname: Vivekanandan
authors.forename: Madugundu Guru
authors.initials: MG
authors.lastname: Swamy
authors.forename: Sudhanand
authors.initials: S
authors.lastname: Prasad
authors.forename: Golak Chandra
authors.initials: GC
authors.lastname: Maikap
authors.forename: Rama
authors.initials: R
authors.lastname: Mukherjee
authors.forename: Anand C
authors.initials: AC
authors.lastname: Burman
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D016190:Carboplatin / Q000737:chemistry*; D004355:Drug Stability; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000970:Antineoplastic Agents; D012996:Solutions; D016190:Carboplatin