The use of microorganisms in L-ascorbic acid production.
L-Ascorbic acid has been industrially produced for around 70 years. Over the past two decades, several innovative bioconversion systems have been proposed in order to simplify the long time market-dominating Reichstein method, a largely chemical synthesis by which still a considerable part of L-ascorbic acid is produced. Here, we describe the current state of biotechnological alternatives using bacteria, yeasts, and microalgae. We also discuss the potential for direct production of l-ascorbic acid exploiting novel bacterial pathways. The advantages of these novel approaches competing with current chemical and biotechnological processes are outlined.
Bremus
Christoph
C
Forschungszentrum Jülich GmbH, Institut für Biotechnologie 1, Jülich, Germany.
Herrmann
Ute
U
Bringer-Meyer
Stephanie
S
Sahm
Hermann
H
D001205:Ascorbic Acid / Q000096:biosynthesis*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D002384:Catalysis; D056890:Eukaryota / Q000235:genetics / Q000378:metabolism; D005285:Fermentation; D005818:Genetic Engineering / Q000379:methods*; D066298:In Vitro Techniques; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D001205:Ascorbic Acid