title: Mononuclear copper active-oxygen complexes.
abstract: There have been significant advances in the understanding of the dioxygen-activation chemistry of mononuclear copper monooxygenases such as peptidylglycine alpha-amidating monooxygenase and dopamine beta-monooxygenase (DbetaM). Recent structural and spectroscopic studies on a series of biomimetic model compounds have provided new and valuable insights into the key reactive intermediates involved in the dioxygen processing at the mononuclear copper reaction centers in biological systems.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. shinobu@sci.osaka-cu.ac.jp
authors.forename: Shinobu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D003300:Copper / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism; D011485:Protein Binding
chemical_list: D009097:Multienzyme Complexes; D010545:Peroxides; D003300:Copper; D006899:Mixed Function Oxygenases; D004299:Dopamine beta-Hydroxylase; C035189:peptidylglycine monooxygenase; D010100:Oxygen