title: [A new cause of intra and extrahepatic cholangitis: the drug hypersensitivity syndrome or DRESS (Drug Rash with Eosinophilia and Systemic Symptoms)].
abstract: The DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) corresponds to a drug reaction generally including cutaneous eruption, fever, hematologic abnormalities such as eosinophilia and atypical lymphocytosis and one or more specific visceral lesions specially in the liver. We report a case of drug hypersensitivity syndrome or DRESS associated with intra and extra-hepatic biliary lesions. This syndrome was associated with sulfasalazine and naproxene therapy. A reactivation of HHV6 was documented in the continuations of the DRESS and could play a role in the symptomms.
authors.affiliation: Services d'Hépato-Gastroentérologie, Hôpital Saint-Camille, Bry-sur-Marne. B.Condat@ch-bry.org
authors.forename: Bertrand
authors.initials: B
authors.lastname: Condat
authors.forename: David
authors.initials: D
authors.lastname: Zanditenas
authors.forename: Véronique
authors.initials: V
authors.lastname: Collot
authors.forename: Nathalie
authors.initials: N
authors.lastname: Legoupil
authors.forename: Dominique
authors.initials: D
authors.lastname: Cazals-Hatem
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Hauuy
authors.forename: Joëlle
authors.initials: J
authors.lastname: Bonnet
authors.forename: Yann
authors.initials: Y
authors.lastname: Ngo
authors.forename: Jacques
authors.initials: J
authors.lastname: Roucoules
authors.forename: Martine
authors.initials: M
authors.lastname: Blazquez
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002761:Cholangitis / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000150:complications*; D004802:Eosinophilia / Q000139:chemically induced; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D008297:Male; D009288:Naproxen / Q000009:adverse effects* / Q000627:therapeutic use; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine; D009288:Naproxen