title: Aortic coarctation induces oxidative stress in rat tissues.
abstract: The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels of reduced glutathione (48%), lipid peroxidation (148%) and activation of superoxide dismutase and glutathione peroxidase (189% and 37%, respectively), compared with controls. Other oxidative stress indicators were also altered in erythrocytes from Coa rats: increased protein carbonyl content (141%) and total glutathione level (349%) were determined. Inactivation of the antioxidant enzymes catalase (27%), superoxide dismutase (58%) and glutathione peroxidase (25%) was observed in erythrocytes from the Coa group. Taken jointly our results provide strong evidence for the production of oxidative stress in heart and erythrocytes from aortic coarcted rats.
authors.affiliation: Departamento de Química Biológica, Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina.
authors.forename: Ariel Héctor
authors.initials: AH
authors.lastname: Polizio
authors.forename: Susana
authors.initials: S
authors.lastname: Gorzalczany
authors.forename: Carlos
authors.initials: C
authors.lastname: Taira
authors.forename: Clara
authors.initials: C
authors.lastname: Peña
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001012:Aorta, Abdominal; D001017:Aortic Coarctation / Q000150:complications / Q000201:enzymology / Q000378:metabolism*; D001835:Body Weight; D006332:Cardiomegaly / Q000201:enzymology / Q000209:etiology / Q000378:metabolism; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009929:Organ Size; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D005978:Glutathione