Hypertension and kidney damage.
Substantial evidence indicates that hypertension is a major contributor to the development of end-stage renal disease in most patients. However, such risk ranges from being fairly low in essential hypertension to a marked increase in susceptibility to hypertensive injury in patients with chronic kidney disease, including diabetic nephropathy. Studies in experimental animal models using blood pressure radiotelemetry have provided significant insights into the quantitative relationships between blood pressure and renal damage and the importance of protective renal autoregulatory capacity as a determinant of such differences in susceptibility to hypertensive injury. Moreover, such investigations have also emphasized the predominant importance of achieving normotension per se over the selection of particular antihypertensive regimens, including renin-angiotensin system blockade, in slowing the progression of chronic kidney disease.
Griffin
Karen A
KA
Loyola University Medical Center and Edward Hines VA Hospital, Maywood, IL 60153, USA. kgriffi@lumc.edu
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004198:Disease Susceptibility; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000503:physiopathology*; D023421:Models, Animal; D018570:Risk Assessment; D012307:Risk Factors
D000959:Antihypertensive Agents