How should patients with Barrett's esophagus be monitored?
Some patients who have been diagnosed with Barrett's esophagus will develop dysplasia and, in some cases, esophageal carcinoma (strength of recommendation [SOR]: A, based on consistent cohort studies). Endoscopic surveillance is recommended for all patients with Barrett's esophagus as it is superior to other methods for detecting esophageal cancer (SOR: B, based on systematic review). The degree of dysplasia noted on biopsy specimens correlates with the risk of esophageal carcinoma development and should guide the frequency of subsequent evaluations (SOR: B, based on consistent cohort studies). The optimal frequency of endoscopy has yet to be determined in any randomized trial. Recommendations from the 2002 American College of Gastroenterology (ACG) Practice Guideline provide guidance as to the frequency of endoscopy surveillance but were not based on an explicit systematic review of the literature (SOR: C, based on expert opinion).
Grover
Michael
M
Department of Family Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Strickland
Carmen
C
Kesler
Ellen
E
Crawford
Paul
P
D000230:Adenocarcinoma / Q000473:pathology / Q000517:prevention & control*; D001471:Barrett Esophagus / Q000473:pathology*; D001706:Biopsy; D016145:Endoscopy, Digestive System; D004938:Esophageal Neoplasms / Q000473:pathology / Q000517:prevention & control*; D006801:Humans