title: Exercise rehabilitation in heart disease: the real "polypill" for primary and secondary prevention.
abstract: Our society is currently at war against the ominous enemy of chronic disease. Chronic disease presents a heavy burden to society, in terms of both medical costs and human suffering. It is our perception that: 1) much of the medical community underpractises primary prevention as regards appropriate levels of physical activity for health, and 2) much of the research community undervalues the importance of understanding the physiological, genetic and clinical bases of diseases caused by physical inactivity. For many, exercise is viewed solely as a research or diagnostic tool and not as a true weapon against chronic disease. In reality, however, exercise attacks the roots of chronic disease, i.e. physical inactivity. The first step in a common "battle plan" is to convince the medical community that chronic disease is rooted in physical inactivity. In this review, we focus on the biological evidence to date showing how physical inactivity leads to chronic disease. One purpose of this review is to demonstrate that exercise, such as treadmill testing of humans for cardiac dysfunctions, is more than a diagnostic tool but part of disease management itself.
authors.forename: Massimo F
authors.initials: MF
authors.lastname: Piepoli
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D002908:Chronic Disease; D003327:Coronary Disease / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D015444:Exercise; D005080:Exercise Test; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006331:Heart Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000534:rehabilitation*; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D008019:Life Style; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011322:Primary Prevention; D016032:Randomized Controlled Trials as Topic; D012106:Research; D012307:Risk Factors; D013997:Time Factors; D016138:Walking
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin