title: Mitomycin-c application in airway stenosis surgery: analysis of safety and costs.
abstract: OBJECTIVE
  This study describes a large series of patients receiving topical mitomycin-c (MMC) during airway surgery, including complications, and carries out a cost analysis for its use in laryngotracheal stenosis.
  
  
  METHODS
  Retrospective review, tertiary center. Airway patients receiving MMC are reviewed for demographics, stenosis characteristics, and MMC usage. A basic cost analysis is carried out.
  
  
  RESULTS
  Fifty patients underwent 93 MMC applications (mean = 50.8 years, 25 male, 25 female). In 89 of 93 applications (96%), the concentration of MMC was 0.4 mg/ml. One major complication occurred (1.1%). The expense for MMC is $455; the mean cost for airway surgery is $7,840. It is estimated that if 1 of 17 MMC treated patients requires one less operation, the cost ratio is favorable.
  
  
  CONCLUSIONS
  This large series contributes to literature that MMC is a safe adjunct to laryngotracheal surgery. The marginal cost for MMC application is favorable based on our basic cost analysis and existing efficacy data.
  
  
  CONCLUSIONS
  Mitomycin-c seems to be safe and cost-effective in endoscopic airway surgery.
  
  
  METHODS
  C-4.
authors.affiliation: Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. mubell@mcw.edu
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Ubell
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Ettema
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Toohill
authors.forename: C Blake
authors.initials: CB
authors.lastname: Simpson
authors.forename: Albert L
authors.initials: AL
authors.lastname: Merati
mesh_terms: D000768:Anesthesia, General / Q000191:economics; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D004106:Dilatation; D016527:Drug Costs; D005260:Female; D017721:Hospital Costs; D006801:Humans; D007828:Laryngoscopy / Q000191:economics; D007829:Laryngostenosis / Q000191:economics / Q000601:surgery*; D053685:Laser Therapy / Q000191:economics; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D009873:Operating Rooms / Q000191:economics; D010781:Photography / Q000191:economics; D012189:Retrospective Studies; D013997:Time Factors; D014135:Tracheal Stenosis / Q000191:economics / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin