title: Risk factors for severe coronary artery disease - a case-control study of patients who have undergone coronary artery bypass grafting.
abstract: To investigate risk factors for coronary artery disease (CAD), we analyzed the clinical parameters of patients with a coronary artery bypass graft (CABG) in a case-control study. Eighty-eight patients (75 males and 13 females) who underwent CABG surgery between 2001 and 2002 were compared with age- and sex-matched healthy controls randomly chosen from the registry of Kobari Health Care Center. Wilcoxon's signed rank test and McNemar's test were used for pairwise comparisons. Multivariate logistic regression analysis was used to identify significant risk factors for CABG. Significant differences between the patients and controls were observed in HDL-C (p < 0.001), HbA(1c) (p < 0.001), Brinkman Index (BI; p < 0.001), body mass index (BMI; p = 0.002), and systolic blood pressure (SBP; p = 0.013). Subjects with an abnormal BMI, HbA(1c), or HDL-C or high BI value made up a significantly higher proportion of the patients who underwent CABG, compared to their age- and sex-matched controls. Multivariate logistic regression analysis identified high levels of HbA(1c), low levels of HDL-C, and high scores on the BI as significant risk factors for needing a CABG. These results demonstrate that, despite the modification of laboratory determinations by antecedent treatment, HDL-C, HbA(1c), BI, BMI, and SBP are significant indicators of risk for CAD.
authors.affiliation: Diabetes Center, Niigata-Kobari Hospital, Niigata, Japan. kkosuge@med.niigata-u.ac.jp
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Kosuge
authors.forename: Hideo
authors.initials: H
authors.lastname: Sasaki
authors.forename: Tomoo
authors.initials: T
authors.lastname: Ikarashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Toyabe
authors.forename: Kohei
authors.initials: K
authors.lastname: Akazawa
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kobayashi
authors.forename: Eri
authors.initials: E
authors.lastname: Abe
authors.forename: Akiko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Saito
authors.forename: Shoji
authors.initials: S
authors.lastname: Eguchi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000209:etiology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects
chemical_list: D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin