Mouse morphological phenotyping with magnetic resonance imaging.
The field of mouse phenotyping with magnetic resonance imaging (MRI) is rapidly growing, with both MRI physicists and biologists starting to use MRI to identify mouse models of human disease. The purpose of this chapter is to provide details of the animal handling necessary for routine and robust in vivo imaging with particular emphasis on multiple-mouse imaging. In addition, techniques for perfusion-fixation for postmortem imaging of specimens and whole mice are given.
Chen
X Josette
XJ
Department of Medical Biophysics, University of Toronto, Ontario, Canada.
D000818:Animals; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000662:veterinary*; D051379:Mice / Q000033:anatomy & histology* / Q000145:classification*; D010641:Phenotype; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods / Q000662:veterinary; D051598:Whole Body Imaging / Q000295:instrumentation / Q000379:methods* / Q000662:veterinary*