title: Candida krusei transmission among hematology patients resolved by adapted antifungal prophylaxis and infection control measures.
abstract: A sudden increase in neutropenic hematology patients with Candida krusei colonization and bacteremia prompted a longitudinal epidemiological investigation. We identified 39 patients; 13 developed candidemia, and three died; 25 patients carried the same genotype. We intervened by changing antifungal prophylaxis and implementing strict infection control measures. The incidence dropped immediately.
authors.affiliation: Department of Medical Microbiology & Infectious Diseases, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. m.vos@erasmusmc.nl
authors.forename: Margreet C
authors.initials: MC
authors.lastname: Vos
authors.forename: Hubert P
authors.initials: HP
authors.lastname: Endtz
authors.forename: Deborah
authors.initials: D
authors.lastname: Horst-Kreft
authors.forename: Jeanette
authors.initials: J
authors.lastname: Doorduijn
authors.forename: Elly
authors.initials: E
authors.lastname: Lugtenburg
authors.forename: Henri A
authors.initials: HA
authors.lastname: Verbrugh
authors.forename: Bob
authors.initials: B
authors.lastname: Löwenberg
authors.forename: Siem
authors.initials: S
authors.lastname: de Marie
authors.forename: Cindy
authors.initials: C
authors.lastname: van Pelt
authors.forename: Alex
authors.initials: A
authors.lastname: van Belkum
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage; D002175:Candida / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission*; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D005838:Genotype; D006402:Hematologic Diseases / Q000150:complications; D006801:Humans; D008137:Longitudinal Studies; D009426:Netherlands / Q000453:epidemiology; D009503:Neutropenia / Q000150:complications
chemical_list: D000935:Antifungal Agents