Macroscopic, histologic, histochemical, immunohistochemical, and ultrastructural features of mesothelioma.
Mesotheliomas are uncommon neoplasms that arise from the cells forming the serosal membranes of the body cavities. Approximately 90-95% of mesotheliomas arise in the pleural cavity and 5-10% in the peritoneal cavity. Rare mesotheliomas arise in the pericardium and in the tunica vaginalis. Unlike many neoplasms, mesotheliomas grow in a diffuse distribution and tend to encase the organs in the various body cavities. A combination of histochemical, immunohistochemical, and ultrastructural features are often necessary to accurately diagnose mesotheliomas. These techniques are highlighted in this review article on mesothelioma.
Hammar
Samuel P
SP
Diagnostic Specialties Laboratories, Bremerton, Washington 98310, USA. shammar@harrisonmedical.org
D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission / Q000379:methods; D010534:Peritoneal Neoplasms / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D010997:Pleural Neoplasms / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure
D014408:Biomarkers, Tumor