title: Effects of four weeks L-carnitine L-tartrate ingestion on substrate utilization during prolonged exercise.
abstract: In a randomized, placebo-controlled, double-blind crossover design, 15 trained males undertook exercise trials during two 4 wk supplementation periods, with either 3 g L-Carnitine L-tartrate (LCLT) or 3 g placebo (P) daily. Total carbohydrate and fat oxidation during 90 min steady state cycling were not different between 0 or 4 wk within LCLT or P trials (mean +/- standard deviation: carbohydrate oxidation P0 99 +/- 36, P4W 111 +/- 27, LCLT0 107 +/- 33, LCLT4W 112 +/- 32 g, respectively; fat oxidation P0 99 +/- 28, P4W 92 +/- 21, LCLT0 94 +/- 18, LCLT4W 90 +/- 22 g, respectively). Subsequent 20 km time trial duration was shorter after P (P0 31:29 +/- 3:50, P4W 29:55 +/- 2:58 min:s, P < 0.01), with no significant change over LCLT (LCLT0 31:46 +/- 4:06, LCLT4W 31.19 +/- 4.08 min:s). Four weeks LCLT supplementation had no effect on substrate utilization or endurance performance.
authors.affiliation: Dept of Sports Studies, University of Stirling, Scotland, UK.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Broad
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Maughan
authors.forename: Stuart D R
authors.initials: SD
authors.lastname: Galloway
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001642:Bicycling / Q000502:physiology*; D002331:Carnitine / Q000008:administration & dosage* / Q000097:blood / Q000652:urine; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D013644:Tartrates / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D013644:Tartrates; D002331:Carnitine; C029768:tartaric acid