Schizophrenia, neurobiology and the methodology of systemic modeling.
Progress in the pharmacological treatment of schizophrenia is dependent on the extent of our understanding of the brain as the basis of this disease. Detailed examination of neurobiological data shows that only a systemic approach will integrate this wealth of information. For this reason, the steps involved in model building should be clarified, as further progress will necessitate closer cooperation between neuropsychiatrists, neurobiologists and systems scientists.
Tretter
F
F
Department of Addiction, District Hospital, Haar/Munich, Germany. tretter@krankenhaus-haar.de
Scherer
J
J
D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D003198:Computer Simulation; D003342:Corpus Striatum / Q000503:physiopathology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology; D016571:Neural Networks, Computer; D009474:Neurons / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012984:Software; D009435:Synaptic Transmission / Q000502:physiology; D013598:Systems Theory