[A respiratory splash of monocytes and neutrophils in familial Mediterranean fever].
OBJECTIVE
To study spontaneous chemotaxis-, phagocytosis-, and proteinkinase C-mediated respiratory splash (RS) of neutrophils and monocytes in colchicin-untreated patients with familial Mediterranean fever (FMF).


METHODS
Of 17 FMF patients, 8 ones were examined during the attack, 9 patients--in fever-free period. Spontaneous and induced RS of peripheral blood neutrophils and monocytes was investigated with quantitative flow-cytofluorimetric method.


RESULTS
Compared to healthy donors, RS is characterized with activation of both spontaneous and induced production of free radicals. The activity and intensity of the RS in FMF was low in the attack vs in the attack-free period but monocytes population has a stable high activity of the RS.


CONCLUSIONS
Activation of neutrophilic RS in FMF patients is characterized by periodicity the direction of which is opposite to induced monocyte activation in the attack and in attack-free interval.
Davtian
T K
TK
Avetisian
S A
SA
Akopian
G S
GS
Arutiunian
V M
VM
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D010505:Familial Mediterranean Fever / Q000097:blood*; D005434:Flow Cytometry; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000097:blood*; D016897:Respiratory Burst / Q000502:physiology*; D012720:Severity of Illness Index
D015415:Biomarkers; D017382:Reactive Oxygen Species