Genomic comparison of Mycobacterium avium subsp. paratuberculosis sheep and cattle strains by microarray hybridization.
Microarray-based comparisons of three Mycobacterium avium subsp. paratuberculosis isolates, including one sheep strain and two cattle strains, identified three large genomic deletions in the sheep strain, totaling 29,208 bp and involving 24 open reading frames. These deletions may help explain some of the differences in pathogenicity and host specificity observed between the cattle and sheep strains of Mycobacterium avium subsp. paratuberculosis.
Marsh
Ian B
IB
Faculty of Veterinary Science, University of Sydney, Camden, NSW, Australia. ian.marsh@agric.nsw.gov.au
Bannantine
John P
JP
Paustian
Michael L
ML
Tizard
Mark L
ML
Kapur
Vivek
V
Whittington
Richard J
RJ
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D016680:Genome, Bacterial; D016927:Mycobacterium avium subsp. paratuberculosis / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D016366:Open Reading Frames; D010283:Paratuberculosis / Q000382:microbiology*; D017384:Sequence Deletion; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology*