Crystal form of cephradine.
Four crystal forms of cephradine were isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. The dissolution patterns of four crystal forms of cephradine were studied in water at 37 +/- 0.5 degrees C, 90 rpm for 120 min. The amount dissolved at 120 min was highest for Form I (100%), followed by Form 3 (98.9%), Form 4 (77.83%), and Form 2 (75.55%). After storage for two months at 0% RH (silica gel, 20 degrees C), 52% RH (saturated solution of Na2Cr2O7 x 2H2O/ 20 degrees C), and 95% RH (saturated solution of Na2HPO4/20 degrees C), none of the crystal forms showed transformation.
Sohn
Young Taek
YT
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea. ytsohn@duksung.ac.kr
Park
Sun Hee
SH
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002515:Cephradine / Q000737:chemistry*; D003460:Crystallization; D004355:Drug Stability; D012995:Solubility; D013818:Thermogravimetry; D013997:Time Factors; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D014867:Water; D002515:Cephradine