Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion.
BACKGROUND
Verrucous carcinoma is a rare condition. A defined disease of the oral cavity, larynx, esophagus, skin, vulva, vagina and cervix. But a verrucous carcinoma arising from the endometrium without evidence of cervical malignancy or endometrial adenocarcinoma is extremely rare.


METHODS
A 67-year-old G2P2 menopausal patient that was referred for consultation 1 year after presenting with vaginal bleeding to her gynecologist who subsequently underwent several endometrial biopsies where the pathological findings were repetitively similar: papillary squamous proliferation, cytologically bland with low mitotic activity but extensive proliferation. A hysterectomy with bilateral salpingo-oophorectomy was performed. The final histologic examination revealed a squamous cell carcinoma of endometrium, verrucous and well differentiated, and there was no cervical invasion identified.


CONCLUSIONS
This is a rare form of endometrial cancer with apparent favorable prognosis that must be considered when squamous cells are identified on endometrial samplings.
Illanes
Diego
D
University of Massachusetts Medical School, Department of Obstetrics and Gynecology, 119 Belmont Street J4, Worcester, MA 01605, USA. illanesd@ummhc.org
Broman
Jerry
J
Meyer
Bruce
B
Kredentser
Daniel
D
McElrath
Timothy
T
Timmins
Patrick
P
D000368:Aged; D018289:Carcinoma, Verrucous / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans