BCG immunotherapy--from pathophysiology to clinical practice.
Treatment with Bacillus Calmette-Guérin vaccine is mainly in use for superficial bladder cancer, for which it is given intravesically. Overall, this therapy is safe with only minor side effects. Arthritis secondary to such therapy has been rarely reported and usually responds well to NSAID treatment. The mechanisms leading to such a complication, as well as the clinical data, are discussed.
Tishler
Moshe
M
Department of Medicine B, Assaf Harofe Medical Center, P.O. Beer Yaacov, Zerifin, 70300, Israel.
Shoenfeld
Yehuda
Y
D000276:Adjuvants, Immunologic / Q000009:adverse effects* / Q000627:therapeutic use; D001168:Arthritis / Q000139:chemically induced* / Q000503:physiopathology; D001327:Autoimmune Diseases; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000502:physiology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000276:immunology
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine