Comparison of fallopian tube sperm perfusion and intrauterine tuboperitoneal insemination: a prospective randomized study.
OBJECTIVE
To evaluate the results of two different methods of insemination: fallopian tube sperm perfusion (FSP) with 4 mL of inseminate and intrauterine tuboperitoneal insemination (IUTPI) with 10 mL of inseminate.


METHODS
Prospective randomized clinical study.


METHODS
Private infertility center.


METHODS
Two hundred seventy-six couples, undergoing 403 cycles, with unexplained infertility, mild or moderate male infertility, or mild or moderate endometriosis.


METHODS
Patients were assigned randomly to either FSP (group A, n = 138) or IUTPI (group B, n = 138) treatment. Both groups followed the same mild ovarian stimulation protocol.


METHODS
Ninety-five overall pregnancies: 35 in group A (FSP) and 60 in group B (IUTPI).


RESULTS
The pregnancy rate per cycle (presence of gestational sac with heart beats) was 17.6% in group A (n = 199) and 29.4% in group B (n = 204). These differences were statistically significant (P < .007). The odds ratio of getting pregnant, per patient, in group B was 2.26 (95% confidence interval 1.36-3.77) compared with group A.


CONCLUSIONS
The results of this study indicate that IUTPI may prove to be a useful technique in the treatment of unexplained infertility, mild or moderate male infertility, and mild or moderate endometriosis. Three attempts of IUTPI may be beneficial before moving on to more invasive and expensive methods of assisted reproduction techniques.
Mamas
Leonidas
L
Neogenesis IVF Center, Athens, Greece. leonidasmamas@neogenesis.gr
D000328:Adult; D004715:Endometriosis / Q000150:complications; D005187:Fallopian Tubes; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000379:methods* / Q000592:standards; D008297:Male; D010477:Perfusion; D010537:Peritoneum; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D014599:Uterus