title: Comment on the paper "Comparison of the measured phase diagrams in the force-temperature plane for the unzipping of two different natural DNA sequences" by C.H. Lee, C. Danilowicz, V.W. Coljee, and M. Prentiss.
abstract: The paper by Lee et al. describes the experiments on the unzipping of lambda DNA sequences as a function of force and temperature. This comment aims to stress that the unzipping takes place out of equilibrium due to high sequence-dependent free-energy barriers. The force at which a heterogeneous sequence is unzipped therefore depends on the experimental waiting time.
authors.affiliation: Laboratoire de Physique Statistique de l'ENS, CNRS, 24 rue Lhomond, 75005, Paris, France. simona.cocco@lps.ens.fr
authors.forename: S
authors.initials: S
authors.lastname: Cocco
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D004279:DNA, Viral / Q000737:chemistry; D009690:Nucleic Acid Conformation; D013314:Stress, Mechanical
chemical_list: D004279:DNA, Viral; D004247:DNA