title: Cancellous bone from porous Ti6Al4V by multiple coating technique.
abstract: A highly porous Ti6Al4V with interconnected porous structure has been developed in our previous study. By using a so-called "Multiple coating" technique, the porous Ti6Al4V can be tailored to resemble cancellous bone in terms of porous structure and mechanical properties. A thin layer of Ti6Al4V slurry was coated on the struts of base porous Ti6Al4V to improve the pore structure. After two additional coating, pore sizes ranged from 100 microm to 700 microm, and the porosity was decreased from approximately 90% to approximately 75%, while the compressive strength was increased from 10.3 +/- 3.3 MPa to 59.4 +/- 20.3 MPa and the Young's modulus increased from 0.8 +/- 0.3 GPa to 1.8 +/- 0.3 GPa. The pore size and porosity are similar to that of cancellous bone, meanwhile the compressive strength is higher than that of cancellous bone, and the Young's modulus is between that of cancellous bone and cortical bone. Porosity, pore size and mechanical properties can be controlled by the parameters in such multiple coating processes. Therefore the porous Ti6Al4V with the characteristics of cancellous bone is expected to be a promising biomaterial for biomedical applications.
authors.affiliation: iBME, Twente University, Prof.Bronkhorstlaan10D, 3723MB, Bilthoven, The Netherlands. j.li@tnw.utwente.nl
authors.forename: J P
authors.initials: JP
authors.lastname: Li
authors.forename: S H
authors.initials: SH
authors.lastname: Li
authors.forename: C A
authors.initials: CA
authors.lastname: Van Blitterswijk
authors.forename: K
authors.initials: K
authors.lastname: de Groot
mesh_terms: D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D018786:Bone Substitutes; D001842:Bone and Bones / Q000473:pathology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D019245:Compressive Strength; D006041:Goats; D008422:Materials Testing; D016348:Osseointegration; D010539:Permeability; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D019736:Prostheses and Implants; D013314:Stress, Mechanical; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D011108:Polymers; C031462:titanium alloy (TiAl6V4); D014025:Titanium