Attacking pathogens through their hosts.
Through understanding the intricacies of host-pathogen interactions, it is now possible to inhibit the growth of microbes, especially viruses, by targeting host-cell proteins and functions. This new antimicrobial strategy has proved effective in the laboratory and in the clinic, and it has great potential for the future.
Kellam
Paul
P
Virus Genomics and Bioinformatics Group, Division of Infection and Immunity, University College London, London W1T 4JF, UK. p.kellam@ucl.ac.uk
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006678:HIV / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity*; D006790:Host-Parasite Interactions / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008954:Models, Biological
D000890:Anti-Infective Agents; D000998:Antiviral Agents