The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study.
OBJECTIVE
Although repair of left ventricular aneurysm has been extensively studied, its effect on regional ventricular function remains unclear. The primary goal of this study was to quantify the effect of anteroapical aneurysm plication on systolic deformation in noninfarcted adjacent (border zone) and remote left ventricular regions in sheep.


METHODS
Eight sheep underwent anteroapical myocardial infarction (25% of left ventricular mass). Ten weeks later, animals underwent aneurysm plication. Two and 6 weeks after this operation, animals underwent magnetic resonance imaging with tissue tagging in multiple short-axis and long-axis slices. Fully 3-dimensional strain analyses were performed. All 6 end-systolic strain components were compared at midwall in the border zone of the aneurysm or repair and in regions 1 cm, 2 cm, and 3 cm below the valves.


RESULTS
Circumferential shortening progressively increases from before plication to 2 weeks after plication to 6 weeks after plication toward the border zone. The effect on circumferential shortening is most pronounced in the anterior wall and septum. The biggest change is from 2 to 6 weeks after plication (from 4.3% to 11.3% in anterior wall, P < .0001; from 3.5% to 6.5% in septum, P < .0007). Longitudinal shortening is decreased at 2 weeks after plication but then returns to baseline (with slight improvement in the border zone) at 6 weeks after plication.


CONCLUSIONS
Repair of left ventricular aneurysm significantly increases systolic circumferential shortening at the border zone in sheep.
Guccione
Julius M
JM
Department of Surgery, University of California, San Francisco, Calif, USA. Julius.Guccione@med.va.gov
Walker
Joseph C
JC
Beitler
Jeremy R
JR
Moonly
Scott M
SM
Zhang
Peng
P
Guttman
Michael A
MA
Ozturk
Cengizhan
C
McVeigh
Elliot R
ER
Wallace
Arthur W
AW
Saloner
David A
DA
Ratcliffe
Mark B
MB
D000818:Animals; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods; D006322:Heart Aneurysm / Q000503:physiopathology* / Q000601:surgery*; D006352:Heart Ventricles / Q000503:physiopathology*; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000601:surgery*; D012756:Sheep; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology