title: Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy.
abstract: Tumour-associated macrophages (TAM) represent the major inflammatory component of the stroma of many tumours, and can affect different aspects of the neoplastic tissue. Many observations indicate that TAM express several M2-associated pro-tumoural functions, including promotion of angiogenesis, matrix remodelling and suppression of adaptive immunity. The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumours and poor patient prognosis. Evidence is presented here supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and are a potential target for anti-cancer therapy.
authors.affiliation: Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy. antonio.sica@humanitas.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Sica
authors.forename: Tiziana
authors.initials: T
authors.lastname: Schioppa
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Paola
authors.initials: P
authors.lastname: Allavena
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D009000:Monocytes / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply / Q000209:etiology* / Q000628:therapy