New self-assembled nanogels based on host-guest interactions: characterization and drug loading.
We show here, for the first time, that two neutral polymers may completely associate together in water to spontaneously form supramolecular nanoassemblies (nanogels) of spherical shape. The cohesion of these stable structures of about 200 nm is based upon a "lock and key" mechanism: inclusion complexes are formed between the hydrophobic alkyl chains grafted on a polysaccharide (dextran) and the molecular cavities contained in a poly-cyclodextrin polymer. Production yields reached 95%. It was established that all the alkyl chains were included within the cyclodextrins' cavities in these nanoassemblies. The multivalent character of the interactions between the two polymers ensures the stability of the nanoassemblies. Moreover, empty cyclodextrin units remained accessible for the inclusion of compounds of interest such as benzophenon or tamoxifen.
Gref
Ruxandra
R
School of Pharmacy, Université Paris Sud, UMR CNRS 8612, 5 Rue J. B. Clément, 92290 Châtenay Malabry, France. ruxanda.gref@cep.u-psud.fr
Amiel
Catherine
C
Molinard
Karine
K
Daoud-Mahammed
Samia
S
Sébille
Bernard
B
Gillet
Brigitte
B
Beloeil
Jean-Claude
JC
Ringard
Catherine
C
Rosilio
Véronique
V
Poupaert
Jaques
J
Couvreur
Patrick
P
D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry; D001577:Benzophenones / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers; D005782:Gels; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D049329:Nanostructures; D011108:Polymers / Q000737:chemistry*; D013500:Surface Tension; D013629:Tamoxifen / Q000737:chemistry; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
D018931:Antineoplastic Agents, Hormonal; D001577:Benzophenones; D003911:Dextrans; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; D047392:beta-Cyclodextrins; D014867:Water; D013629:Tamoxifen; C047723:benzophenone