title: Anatomic extent of colitis and disease severity are not predictors of pouchitis after restorative proctocolectomy for mucosal ulcerative colitis.
abstract: BACKGROUND
  Pouchitis is a common complication following restorative proctocolectomy with ileal pouch anal anastomosis (RPC-IPAA) for mucosal ulcerative colitis (MUC). The aim of this study was to determine if perioperative anatomic extent and severity of disease are predictors of pouchitis.
  
  
  METHODS
  All consecutive patients who underwent RPC-IPAA for MUC between 1988 and 2002 were retrospectively studied. Pouchitis was classified as acute, recurrent or refractory. Colectomy specimen slides were histopathologically evaluated by a single blinded pathologist (MB), who assessed extent and severity of disease.
  
  
  RESULTS
  Of 112 patients assessed, 70 (62.5%) had some form of pouchitis at a median follow-up of 38 months (range, 1-204 months). No association was found between the extent or severity of disease and subsequent development of acute or chronic pouchitis. A positive correlation was found between the histopathologic score and the occurrence of clinical pouchitis (p=0.014). The presence of colonic metaplasia in the pouch biopsy was significantly correlated with a histopathologic diagnosis of pouchitis (p<0.0001, r=-0.449).
  
  
  CONCLUSIONS
  Following RPC for MUC, the extent and severity of disease do not predict the subsequent development of pouchitis.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL 33331, USA.
authors.forename: N
authors.initials: N
authors.lastname: Sengul
authors.forename: S D
authors.initials: SD
authors.lastname: Wexner
authors.forename: S M
authors.initials: SM
authors.lastname: Hui
authors.forename: M K
authors.initials: MK
authors.lastname: Baig
authors.forename: N
authors.initials: N
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Connor
authors.forename: E G
authors.initials: EG
authors.lastname: Weiss
authors.forename: J J
authors.initials: JJ
authors.lastname: Nogueras
authors.forename: M
authors.initials: M
authors.lastname: Berho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003093:Colitis, Ulcerative / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019449:Pouchitis / Q000209:etiology*; D011237:Predictive Value of Tests; D016737:Proctocolectomy, Restorative; D012189:Retrospective Studies; D012720:Severity of Illness Index