Genome-wide prediction of C. elegans genetic interactions.
To obtain a global view of functional interactions among genes in a metazoan genome, we computationally integrated interactome data, gene expression data, phenotype data, and functional annotation data from three model organisms-Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster-and predicted genome-wide genetic interactions in C. elegans. The resulting genetic interaction network (consisting of 18,183 interactions) provides a framework for system-level understanding of gene functions. We experimentally tested the predicted interactions for two human disease-related genes and identified 14 new modifiers.
Zhong
Weiwei
W
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Sternberg
Paul W
PW
D000465:Algorithms; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D004331:Drosophila melanogaster / Q000235:genetics; D049751:Genome, Helminth; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000235:genetics