title: Synthesis of multisubstituted quinolines from Baylis-Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity.
abstract: Baylis-Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta[g]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S(N)2'-S(N)Ar elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity.
authors.affiliation: Organic Chemistry Division-II, Indian Institute of Chemical Technology, Tarnaka, Hyderabad.
authors.forename: P
authors.initials: P
authors.lastname: Narender
authors.forename: U
authors.initials: U
authors.lastname: Srinivas
authors.forename: M
authors.initials: M
authors.lastname: Ravinder
authors.forename: B Ananda
authors.initials: BA
authors.lastname: Rao
authors.forename: Ch
authors.initials: Ch
authors.lastname: Ramesh
authors.forename: K
authors.initials: K
authors.lastname: Harakishore
authors.forename: B
authors.initials: B
authors.lastname: Gangadasu
authors.forename: U S N
authors.initials: US
authors.lastname: Murthy
authors.forename: V Jayathirtha
authors.initials: VJ
authors.lastname: Rao
mesh_terms: D000085:Acetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000085:Acetates; D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011804:Quinolines; C014785:3-pyridinaldehyde