title: Pharmacological-induced haptic changes and the accommodative performance in patients with the AT-45 accommodative IOL.
abstract: OBJECTIVE
  To investigate the accommodative performance of the AT-45 (eyeonics Inc, Aliso Viejo, Calif) using three-dimensional ultrasound biomicroscopy.
  
  
  METHODS
  The AT-45 haptic region was visualized in vivo 1 month after surgery in four patients using an in-house developed three-dimensional ultrasound biomicroscope. Haptic changes, axial shift, and accommodation amplitude were determined under pharmacologically induced accommodation.
  
  
  RESULTS
  The angulation, depending on the accommodation state, could be distinguished and analyzed. In vivo a mean change in haptic angulation of 3.3 +/- 3.3 degrees (range: 0 degrees to 7 degrees) and a mean forward shift of 0.13 +/- 0.08 mm (range: 0.05 to 0.2 mm) were observed for the AT-45 using pharmacologically induced accommodation. A mean accommodative amplitude of 0.44 +/- 0.24 diopters (D) (range: 0.25 to 0.75 D) was found using a Hartinger coincidence refractometer.
  
  
  CONCLUSIONS
  Minimal angulation changes and axial movements of the AT-45 have been demonstrated using pharmacological stimulation and objective measurement methods. The mechanical performance of the AT-45 in these eyes does not appear to provide the range of accommodation necessary for close work.
authors.affiliation: Eye Clinic of the University of Rostock, Rostock, Germany. oliver.stachs@med.uni-rostock.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Stachs
authors.forename: Hanka
authors.initials: H
authors.lastname: Schneider
authors.forename: Ria
authors.initials: R
authors.lastname: Beck
authors.forename: Rudolf
authors.initials: R
authors.lastname: Guthoff
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects* / Q000502:physiology; D000368:Aged; D003519:Cyclopentolate / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007910:Lenses, Intraocular; D033401:Microscopy, Acoustic; D008875:Middle Aged; D008916:Miotics / Q000008:administration & dosage*; D009184:Mydriatics / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage; D011474:Prosthesis Design; D019591:Pseudophakia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012029:Refraction, Ocular / Q000187:drug effects / Q000502:physiology
chemical_list: D008916:Miotics; D009184:Mydriatics; D009883:Ophthalmic Solutions; D010862:Pilocarpine; D003519:Cyclopentolate