A new cytotoxic lanostane triterpenoid from the basidiomycete Hebeloma versipelle.
A new cytotoxic lanostane triterpenoid, 24(E)-3beta-hydroxylanosta-8,24-dien-26-al-21-oic acid (1), was isolated from the fruiting bodies of the mushroom Hebeloma versipelle. The structure was elucidated on the basis of spectroscopic studies including 2D NMR experiments. Compound 1 moderately inhibited the growth of several tumor cell lines (IC50 10-25.0 microg/ml).
Shao
Hong-Jun
HJ
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
Qing
Chen
C
Wang
Fei
F
Zhang
Yan-Li
YL
Luo
Du-Qiang
DQ
Liu
Ji-Kai
JK
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D001487:Basidiomycota / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles
C508793:3-hydroxylanosta-8,24-dien-26-al-21-oic acid; D000903:Antibiotics, Antineoplastic; D013778:Tetrazolium Salts; D013844:Thiazoles; D007810:Lanosterol; C022616:thiazolyl blue