title: [Effect of anti-influenza virus of Arctigenin in vivo].
abstract: OBJECTIVE
  To study anti-influenza virus effect of Arctigenin in vivo.
  
  
  METHODS
  The influences on lung index, death rate of mice infected by influenza virus were observed in the mice infected with virus from nose.
  
  
  RESULTS
  Experiments in vivo showed that Arctigenin at the concentration of 100 microg/kg and 10 microg/kg for the intranasal treatment markedly inhibited the lung consolidation of mice pneumonia caused by the infection of influenza virus. Arctigenin at the concentration of 100 microg/kg prolonged the survival time of mice infected with influenza virus.
  
  
  CONCLUSIONS
  Arctigenin may be effective on treating influenza.
authors.affiliation: Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405.
authors.forename: Zifeng
authors.initials: Z
authors.lastname: Yang
authors.forename: Ni
authors.initials: N
authors.lastname: Liu
authors.forename: Bisong
authors.initials: B
authors.lastname: Huang
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Wang
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Hu
authors.forename: Yutong
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D031170:Arctium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005663:Furans / Q000494:pharmacology*; D009980:Influenza A virus / Q000187:drug effects*; D017705:Lignans / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011024:Pneumonia, Viral / Q000473:pathology; D012254:Ribavirin / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D012254:Ribavirin; C071942:arctigenin