title: Expression of HER1/EGFR protein in human soft tissue sarcomas.
abstract: OBJECTIVE
  To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples.
  
  
  METHODS
  HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients.
  
  
  RESULTS
  HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues.
  
  
  CONCLUSIONS
  HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.
authors.affiliation: Oncology Research Centre, School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. j.yang@unsw.edu.au
authors.forename: J-L
authors.initials: JL
authors.lastname: Yang
authors.forename: M T
authors.initials: MT
authors.lastname: Hannan
authors.forename: P J
authors.initials: PJ
authors.lastname: Russell
authors.forename: P J
authors.initials: PJ
authors.lastname: Crowe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors