title: Investigation of treatment failure in neonatal echovirus 7 infection.
abstract: We describe a case of fatal neonatal enteroviral infection caused by echovirus 7. Multiple treatments, including specific antiviral therapy, were attempted and failed. Studies of the viral isolate, maternal plasma, intravenous immunoglobulin preparations and pleconaril were performed to identify potential causes for treatment failure.
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. alison.rentz@childrens.harvard.edu
authors.forename: Alison C
authors.initials: AC
authors.lastname: Rentz
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
authors.forename: Frank G
authors.initials: FG
authors.lastname: Whitby
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Byington
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D029822:Enterovirus B, Human / Q000145:classification* / Q000187:drug effects / Q000235:genetics; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D008969:Molecular Sequence Data; D010069:Oxadiazoles / Q000627:therapeutic use*; D010080:Oxazoles; D017422:Sequence Analysis, DNA; D017211:Treatment Failure
chemical_list: D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D010069:Oxadiazoles; D010080:Oxazoles; C115201:pleconaril