title: EHV-1 and EHV-4 infection in vaccinated mares and their foals.
abstract: A silent cycle of equine herpesvirus 1 infection was described following epidemiological studies of unvaccinated mares and foals on a Hunter Valley stud farm. Following the introduction of routine vaccination with an inactivated whole virus equine herpesvirus 1 (EHV-1) and equine herpesvirus 4 (EHV-4) vaccine in 1997, a subsequent study identified excretion of EHV-1 and EHV-4 in nasal swab samples tested by PCR from vaccinated mares and their unweaned, unvaccinated foals. The current sero-epidemiological investigation of vaccinated mares and their young foals found serological evidence of EHV-1 and EHV-4 infection in mares and foals in the first 5 weeks of life. The results further support that EHV-1 and EHV-4 circulate in vaccinated populations of mares and their unweaned foals and confirms the continuation of the cycle of EHV-1 and EHV-4 infection.
authors.affiliation: Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia.
authors.forename: C E
authors.initials: CE
authors.lastname: Foote
authors.forename: D N
authors.initials: DN
authors.lastname: Love
authors.forename: J R
authors.initials: JR
authors.lastname: Gilkerson
authors.forename: J E
authors.initials: JE
authors.lastname: Wellington
authors.forename: J M
authors.initials: JM
authors.lastname: Whalley
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D000914:Antibodies, Viral / Q000097:blood; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D004861:Herpesvirus 1, Equid / Q000254:growth & development*; D023141:Herpesvirus 4, Equid / Q000254:growth & development*; D006734:Horse Diseases / Q000453:epidemiology* / Q000821:virology*; D006736:Horses; D018445:Infectious Disease Transmission, Vertical / Q000662:veterinary; D008137:Longitudinal Studies; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D014611:Vaccination / Q000662:veterinary*; D014759:Viral Envelope Proteins / Q000737:chemistry
chemical_list: D000914:Antibodies, Viral; D014759:Viral Envelope Proteins; C083103:glycoprotein G, Equid herpesvirus 1; C076629:glycoprotein G, Equid herpesvirus 4