Recent developments in the identification of novel oxazolidinone antibacterial agents.
The oxazolidinones are a promising new class of synthetic antibacterial agents. Here, we review recent efforts directed at the discovery of new antibacterial compounds of this class. New structures and structure-activity relationships (SAR) are discussed in the context of earlier work in the field. Key issues of potency, spectrum, selectivity, in vivo efficacy, and pharmacokinetic profile of the new analogs are addressed.
Renslo
Adam R
AR
Vicuron Pharmaceuticals, 34790 Ardentech Ct., Fremont, CA 94555, USA. adam.renslo@ucsf.edu
Luehr
Gary W
GW
Gordeev
Mikhail F
MF
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D023303:Oxazolidinones / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones