Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients.
We searched for genes differentially expressed in the frontal cortices of Alzheimer-type dementia (ATD) patients compared with those of non-ATD controls using DNA microarray and quantitative reverse transcription-polymerase chain reaction (RT-PCR) analyses. Here we show that the expression level of the autotaxin (also called lysophospholipase D or ecto-nucleotide pyrophosphatase/phosphodiesterase 2) gene was significantly greater in ATD cortices than in non-ATD cortices. In both ATD and non-ATD groups, the expression levels were greater in patients with the apoE epsilon3/epsilon4 genotype than in patients with the apoE epsilon3/epsilon3 genotype, although the differences were not statistically significant. These observations suggest that expression of the autotaxin gene and cell signaling by lysophosphatidic acid may be involved in the pathology of ATD, and that this cell signaling pathway may be a potential target of treatments for ATD.
Umemura
Ken
K
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Yamashita
Nobuyuki
N
Yu
Xiaonian
X
Arima
Kunimasa
K
Asada
Takashi
T
Makifuchi
Takao
T
Murayama
Shigeo
S
Saito
Yuko
Y
Kanamaru
Kazutomi
K
Goto
Yuichi
Y
Kohsaka
Shinichi
S
Kanazawa
Ichiro
I
Kimura
Hideo
H
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D015870:Gene Expression / Q000502:physiology*; D006801:Humans; D008297:Male; D009097:Multienzyme Complexes / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D043264:Phosphodiesterase I / Q000235:genetics* / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D000099189:Lysophospholipase D
D001057:Apolipoproteins E; D009097:Multienzyme Complexes; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D012333:RNA, Messenger; D000099189:Lysophospholipase D