Eosinophilic meningitis after implantation of a rifampin and minocycline-impregnated ventriculostomy catheter in a child. Case report.
Eosinophilic meningitis has been defined as meningitis in which a total cerebrospinal fluid (CSF) sample is found to have more than 10 eosinophils per millimeter or is composed of greater than 10% eosinophils. The differential diagnosis is broad and the clinical presentation, lacking an internalized CSF diversion system, is often nonspecific. With respect to patients with shunt systems, a positive correlation exists between CSF eosinophilia and eventual shunt failure requiring revision. In this paper the authors present the highest reported level of CSF eosinophilia in conjunction with a rifampin and minocycline-impregnated ventriculostomy catheter recently approved by the Food and Drug Administration.
Bell
Randy S
RS
National Capital Consortium, Washington, DC, USA. randy.bell@na.amedd.army.mil
Vo
Alexander H
AH
Cooper
Patrick B
PB
Schmitt
Carrie L
CL
Rosner
Michael K
MK
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000627:therapeutic use; D002404:Catheterization; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000209:etiology*; D006801:Humans; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000209:etiology*; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use; D014696:Ventriculostomy / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D008911:Minocycline; D012293:Rifampin