Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection.
Cell-mediated immunity to Toxoplasma gondii establishes and maintains a balanced host-pathogen relationship. Recent analyses using spontaneous and genetically engineered mouse mutants have yielded a clearer picture of factors positively and negatively regulating the host immune response and a better understanding of cytokine-inducible intracytoplasmic mechanisms that lead to intracellular pathogen suppression and demise.
Yap
George S
GS
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA. george_yap@brown.edu
Shaw
Michael H
MH
Ling
Yun
Y
Sher
Alan
A
D000818:Animals; D016207:Cytokines / Q000235:genetics; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D051379:Mice / Q000469:parasitology; D009154:Mutation; D014122:Toxoplasma / Q000502:physiology*; D014123:Toxoplasmosis / Q000235:genetics / Q000276:immunology*; D014617:Vacuoles / Q000469:parasitology
D016207:Cytokines