title: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift.
abstract: OBJECTIVE
  Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. The use of platelet gel to improve bone regeneration is a recent technique in implantology. However, the biologic properties and real effects of such products remain controversial. In this article, we therefore attempt to evaluate the potential of PRF in combination with freeze-dried bone allograft (FDBA) (Phoenix; TBF, France) to enhance bone regeneration in sinus floor elevation.
  
  
  METHODS
  Nine sinus floor augmentations were performed. In 6 sites, PRF was added to FDBA particles (test group), and in 3 sites FDBA without PRF was used (control group). Four months later for the test group and 8 months later for the control group, bone specimens were harvested from the augmented region during the implant insertion procedure. These specimens were treated for histologic analysis.
  
  
  RESULTS
  Histologic evaluations reveal the presence of residual bone surrounded by newly formed bone and connective tissue. After 4 months of healing time, histologic maturation of the test group appears to be identical to that of the control group after a period of 8 months. Moreover, the quantities of newly formed bone were equivalent between the 2 protocols.
  
  
  CONCLUSIONS
  Sinus floor augmentation with FDBA and PRF leads to a reduction of healing time prior to implant placement. From a histologic point of view, this healing time could be reduced to 4 months, but large-scale studies are still necessary to validate these first results.
authors.affiliation: Pain Clinic Center, Nice, France.
authors.forename: Joseph
authors.initials: J
authors.lastname: Choukroun
authors.forename: Antoine
authors.initials: A
authors.lastname: Diss
authors.forename: Alain
authors.initials: A
authors.lastname: Simonpieri
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Girard
authors.forename: Christian
authors.initials: C
authors.lastname: Schoeffler
authors.forename: Steve L
authors.initials: SL
authors.lastname: Dohan
authors.forename: Anthony J J
authors.initials: AJ
authors.lastname: Dohan
authors.forename: Jaafar
authors.initials: J
authors.lastname: Mouhyi
authors.forename: David M
authors.initials: DM
authors.lastname: Dohan
mesh_terms: D001792:Blood Platelets; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000379:methods / Q000502:physiology; D003758:Dental Implantation, Endosseous; D005337:Fibrin / Q000494:pharmacology / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology / Q000627:therapeutic use*; D005782:Gels; D006490:Hemostatics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D010974:Platelet Aggregation
chemical_list: D015718:Fibrin Tissue Adhesive; D005782:Gels; D006490:Hemostatics; D005337:Fibrin