[Effect of anti-influenza virus of Arctigenin in vivo].
OBJECTIVE
To study anti-influenza virus effect of Arctigenin in vivo.


METHODS
The influences on lung index, death rate of mice infected by influenza virus were observed in the mice infected with virus from nose.


RESULTS
Experiments in vivo showed that Arctigenin at the concentration of 100 microg/kg and 10 microg/kg for the intranasal treatment markedly inhibited the lung consolidation of mice pneumonia caused by the infection of influenza virus. Arctigenin at the concentration of 100 microg/kg prolonged the survival time of mice infected with influenza virus.


CONCLUSIONS
Arctigenin may be effective on treating influenza.
Yang
Zifeng
Z
Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405.
Liu
Ni
N
Huang
Bisong
B
Wang
Yanfang
Y
Hu
Yingjie
Y
Zhu
Yutong
Y
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D031170:Arctium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005663:Furans / Q000494:pharmacology*; D009980:Influenza A virus / Q000187:drug effects*; D017705:Lignans / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011024:Pneumonia, Viral / Q000473:pathology; D012254:Ribavirin / Q000494:pharmacology
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D012254:Ribavirin; C071942:arctigenin