title: Screening for familial ovarian cancer--management and outcome of women with moderate to high risk of developing ovarian cancer.
abstract: Five percent to ten percent of ovarian cancers are hereditary. Individual genetic risk of developing ovarian malignancy is discussed in women. Currently, prophylactic surgery is advised to women with a moderate to high risk of developing ovarian cancer. Workload and outcome of the multidisciplinary familial ovarian screening clinic in South Wales were assessed. This was an observational study of 145 women registered with the Familial Ovarian Screening Clinic between January 1998 and December 2003. The data were retrieved from the medical notes. Yearly follow-ups were investigated with a transvaginal scan and CA125 level. Post-surgery women were followed up with yearly CA125 estimations: 46.9% fell into moderate-risk and 50.3% into high-risk category. The median age was 42 (SD 10.4), 71.7% were pre menopausal, and 10.3% had a personal history of breast cancer and 1.4% colon cancer. Whereas 36.5% opted for surgery, the remaining women (but two) opted for annual follow-up. Histology of the women who had surgery showed three cases of malignancies (fallopian tube carcinoma, atypical ovarian epithelial cells, and metastatic breast cancer). Seven women developed breast cancer during the observation period. The follow-up period is too short to come to a final conclusion as to the benefits of yearly screening in this group of women. In our series, a significant number of patients developed malignancies, despite prophylactic surgery.
authors.affiliation: Department Obstetrics and Gynaecology, University of Wales College of Medicine, Cardiff, United Kingdom. RieckGC1@cf.ac.uk
authors.forename: G C
authors.initials: GC
authors.lastname: Rieck
authors.forename: K
authors.initials: K
authors.lastname: Lim
authors.forename: M T
authors.initials: MT
authors.lastname: Rogers
authors.forename: E
authors.initials: E
authors.lastname: France
authors.forename: J R
authors.initials: JR
authors.lastname: Gray
authors.forename: N
authors.initials: N
authors.lastname: Amso
authors.forename: A S
authors.initials: AS
authors.lastname: Evans
authors.forename: R H
authors.initials: RH
authors.lastname: Howells
authors.forename: A N
authors.initials: AN
authors.lastname: Fiander
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000601:surgery; D016896:Treatment Outcome; D016526:Workload