title: RNA granules.
abstract: Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. RNA granules contain various ribosomal subunits, translation factors, decay enzymes, helicases, scaffold proteins, and RNA-binding proteins, and they control the localization, stability, and translation of their RNA cargo. We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay.
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Anderson
authors.forename: Nancy
authors.initials: N
authors.lastname: Kedersha
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis / Q000235:genetics*; D021381:Protein Transport / Q000235:genetics; D020871:RNA Stability / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012335:RNA, Ribosomal / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D013312:Stress, Physiological / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D012335:RNA, Ribosomal; D016601:RNA-Binding Proteins