Emerging drugs for the treatment of sepsis.
Septic shock still places a major burden on the healthcare system, although recent years have been marked by the demonstration that corticosteroids and activated protein C may substantially improve survival in selected populations. This review discusses the current management of septic shock and the potential development of new therapeutics following impressive advances in the pathomechanisms of septic shock.
Aboab
Jérome
J
Intensive Care Unit, University of Versailles Saint Quentin, Hospital Raymond Poincaré, 104 bd Raymond Poincaré, 92380 Garches, France.
Nardi
Olivier
O
Lipiner
Diane
D
Sharshar
Tarek
T
Annane
Djillali
D
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008074:Lipoproteins / Q000627:therapeutic use; D011486:Protein C / Q000627:therapeutic use; D012772:Shock, Septic / Q000188:drug therapy* / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D008074:Lipoproteins; D011486:Protein C; C051928:lipoprotein-associated coagulation inhibitor; D006854:Hydrocortisone