title: Gliosarcoma with liposarcomatous differentiation: the new member of the lipid-containing brain tumors family.
abstract: Gliosarcoma is a rare malignant, biphasic brain tumor composed of glioblastoma multiforme and sarcomatous components. Various types of sarcomatous differentiation are described in this tumor: fibrosarcomatous, malignant fibrous histiocytoma-like, chondrosarcomatous and osteosarcomatous types. We report an extremely unusual variant of liposarcomatous differentiation in gliosarcoma in 72-year-old woman. Fat cells were presented by atypical multivacuolar and monovacuolar lipoblasts, stained positive for S100. p53 that was positive in both glial and mesenchymal cells of the tumor were negative in the lipoblasts. To the best of our knowledge, this is the first report in the literature of liposarcomatous differentiation in gliosarcoma.
authors.affiliation: Department of Pathology, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. e_vlodavsky@rambam.health.gov.il
authors.forename: Eugene
authors.initials: E
authors.lastname: Vlodavsky
authors.forename: Marius
authors.initials: M
authors.lastname: Konstantinesku
authors.forename: Jean F
authors.initials: JF
authors.lastname: Soustiel
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D018316:Gliosarcoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D009418:S100 Proteins / Q000032:analysis; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins; D016159:Tumor Suppressor Protein p53