title: [Range of potential functions of the Drosophila melanogaster hdc gene].
abstract: The Drosophila melanogaster hdc gene controls trachea branching, which starts during embryo development. Expression in imaginal disks and reproductive organs suggests additional functions for the hdc gene. The gene was demonstrated to have a maternal effect, which was denied previously. Analysis of cell proliferation in imaginal disks with hdc mutations showed that the gene does not possess tumor suppressor properties at the levels of mosaic cuticle clones of adults and transplanted imaginal disks. Transplanted imaginal disks homozygous, but not heterozygous, for an hdc mutation were found to affect oogenesis in the recipient females, implicating the hdc activity in exchanging signals between different organs. Amino acid sequence analysis of the Hdc protein revealed a region homologous to the human HRS proteins, which directly interact with the NF2 tumor suppressor on experimental evidence.
authors.forename: A M
authors.initials: AM
authors.lastname: Gusachenko
authors.forename: E M
authors.initials: EM
authors.lastname: Akhmamet'eva
authors.forename: L V
authors.initials: LV
authors.lastname: Omel'ianchuk
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D019521:Body Patterning; D029721:Drosophila Proteins / Q000235:genetics* / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000502:physiology; D005260:Female; D018392:Genomic Imprinting; D006579:Heterozygote; D006720:Homozygote; D007814:Larva; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D009866:Oogenesis; D010053:Ovary / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D014132:Trachea / Q000254:growth & development / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; C098014:Hdc protein, Drosophila