Molecular neurobiological methods in marijuana-cannabinoid research.
Recent aggregation of evidence for the roles of endogenous agonist and receptor systems that are mimicked or activated by cannabanoid ligands has provided a focus for work that has elucidated details of some of the multiple physiological roles and pharmacological functions that these systems play in brain and peripheral tissues. This chapter reviews some of the approaches to improved elucidation of these systems, with special focus on the human genes that encode cannabanoid receptors and the variants in these receptors that appear likely to contribute to human addiction vulnerabilities.
Uhl
George R
GR
Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Ishiguro
Hiroki
H
Onaivi
Emmanuel S
ES
Zhang
Ping-Wu
PW
Akinshola
B Emmanuel
BE
Lin
Zhicheng
Z
Hope
Bruce
B
Leonard
Claire M
CM
Liu
Qing-Rong
QR
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D016466:CHO Cells; D019556:COS Cells; D002186:Cannabinoids / Q000494:pharmacology*; D002188:Cannabis; D002522:Chlorocebus aethiops; D006224:Cricetinae; D015894:Genome, Human; D006801:Humans; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000187:drug effects / Q000378:metabolism; D043885:Receptor, Cannabinoid, CB2 / Q000187:drug effects / Q000378:metabolism; D014982:Xenopus laevis
D002186:Cannabinoids; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2