[Hematopoietic stem cell transplant in combined immunodeficiency syndromes of childhood: an optimal treatment for primary immunodeficiency].
The congenital immunodeficiency disorders in which the defect has been clearly traced to the stem cell can be cured with allogeneic stem-cell transplantation (SCT) from an unaffected donor. Widespread application of this treatment modality has been tempered by the fact that risk-benefit considerations do not always favor a procedure that carries a significant risk for morbidity and mortality. Some malignant disorders of childhood eventually have to be treated by an autologous or allogeneic SCT, however nonmalignant disorders can also be treated with this approach. This article reviews the current status of SCT for nonmalignant inherited immunodeficiency disorders.
Olaya-Vargas
Alberto
A
Programa de Trasplante de Progenitores Hematopoyéticos, Instituto Nacional de Pediatría. albertoolaya@aol.com
Coronel-Moran
Rocío
R
Rivera-Luna
Roberto
R
Bravo-Lindoro
Amalia
A
Bejar-Ramírez
Yadira
Y
Lormendez-Jacome
Doris
D
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015193:Chorionic Villi Sampling; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D005315:Fetal Diseases / Q000601:surgery; D046128:Fetal Therapies; D016332:Fetal Tissue Transplantation; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data; D006648:Histocompatibility; D006801:Humans; D016031:Liver Transplantation; D008212:Lymphocyte Depletion; D008297:Male; D009369:Neoplasms / Q000601:surgery; D018570:Risk Assessment; D016511:Severe Combined Immunodeficiency / Q000145:classification / Q000175:diagnosis / Q000196:embryology / Q000601:surgery*; D013950:Thymus Gland / Q000637:transplantation; D014019:Tissue Donors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014923:Wiskott-Aldrich Syndrome / Q000601:surgery