Amyloid under the atomic force microscope.
The atomic force microscope (AFM) is a versatile instrument that can be used to image biological samples at nanometre resolution as well as to measure inter and intra-molecular forces in air and liquid environments. This review summarises the use of AFM applied to protein and peptide self-assembly systems involved in amyloid formation. The technical principles of the AFM are outlined and its advantages and disadvantages are highlighted and discussed in the context of the rapidly developing field of amyloid research.
Gosal
Walraj S
WS
School of Biochemistry and Microbiology, Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT, UK.
Myers
Sarah L
SL
Radford
Sheena E
SE
Thomson
Neil H
NH
D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure*; D000818:Animals; D005544:Forecasting; D006801:Humans; D018625:Microscopy, Atomic Force
D016229:Amyloid beta-Peptides