title: Family specific rates of protein evolution.
abstract: BACKGROUND
  Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins.
  
  
  RESULTS
  We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.
authors.affiliation: Max Planck Institute for Molecular Genetics Ihnestrasse 73, 14195 Berlin, Germany. luz@molgen.mpg.de
authors.forename: Hannes
authors.initials: H
authors.lastname: Luz
authors.forename: Martin
authors.initials: M
authors.lastname: Vingron
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D003198:Computer Simulation; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D020543:Proteome / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
chemical_list: D020543:Proteome