Indirect determination of Fe(III) in synthetic samples and iron dextran tablets by capillary electrophoresis with ultraviolet detection.
A capillary electrophoresis method based on the oxidation of ascorbic acid is proposed for the indirect determination of Fe(III). Fe(III) concentration corresponds to the decrease in ascorbic acid peak area. The calibration graph was linear in the range of 1.68-112 mg/L for Fe(III), which was easily detected at a concentration of 1.12 mg/L at 3 times the standard deviation of the blank divided by the slope of the calibration graph. The lack of interferences from Fe(II) in synthetic samples and 3 excipients (starch, magnesium strearate, and microcrystalline cellulose) in dextran tablets in the determination of Fe(III) confirmed the high selectivity of the proposed method. Its application to the determination of Fe(III) in several synthetic samples and iron dextran tablets produced excellent results.
Tang
Yajun
Y
National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin St, Changchun 130022, People's Republic of China.
Wu
Mingjia
M
Xu
Yuanhong
Y
D001205:Ascorbic Acid / Q000032:analysis / Q000737:chemistry; D002138:Calibration; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003911:Dextrans / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D007501:Iron / Q000032:analysis* / Q000737:chemistry; D007502:Iron Chelating Agents / Q000494:pharmacology; D007505:Iron-Dextran Complex / Q000032:analysis*; D013011:Sorbic Acid / Q000032:analysis; D013607:Tablets; D013997:Time Factors; D014466:Ultraviolet Rays
D003911:Dextrans; D007502:Iron Chelating Agents; D013607:Tablets; D007505:Iron-Dextran Complex; D007501:Iron; D001205:Ascorbic Acid; D013011:Sorbic Acid