Arginine inhibits Na-driven flagellar motors of alkaliphilic Bacillus.
L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both L- and D-arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus by competing with Na+, which we take as evidence that arginine specifically binds to a molecular target.
Atsumi
Tatsuo
T
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya, Japan. d42981a@cc.nagoya-u.ac.jp
Yoshimura
Fuminobu
F
Sugiyama
Shigeru
S
D001120:Arginine / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects* / Q000502:physiology; D005407:Flagella / Q000187:drug effects*; D020409:Molecular Motor Proteins / Q000187:drug effects*; D009068:Movement / Q000187:drug effects
D020409:Molecular Motor Proteins; D001120:Arginine