title: Prognosis of cough variant asthma: a retrospective analysis.
abstract: Patients with cough variant asthma, a common cause of chronic cough, may develop wheezing. We examined the determinants of this phenomenon and achievement of remission in 42 patients. During 4 years after diagnosis, wheezing developed in 13 of the patients. Early inhaled corticosteroid treatment was inhibitory against the development of wheezing by univariate analysis and by multivariate analysis with an odds ratio of 0.12 (95% confidence interval, 0.02 to 0.87, p = 0.037). Remission was achieved in 7 patients, who were younger than those without remission by univariate analysis (p = 0.048). Early treatment with inhaled corticosteroid may prevent the progression of cough variant asthma to classic asthma.
authors.affiliation: Department of Respiratory Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hisako
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Akio
authors.initials: A
authors.lastname: Niimi
authors.forename: Masaya
authors.initials: M
authors.lastname: Takemura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ueda
authors.forename: Rollin
authors.initials: R
authors.lastname: Tabuena
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Matsuoka
authors.forename: Toyohiro
authors.initials: T
authors.lastname: Hirai
authors.forename: Shigeo
authors.initials: S
authors.lastname: Muro
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
authors.forename: Tadashi
authors.initials: T
authors.lastname: Mio
authors.forename: Kazuo
authors.initials: K
authors.lastname: Chin
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishiyama
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications*; D003371:Cough / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012135:Respiratory Sounds / Q000209:etiology*; D012189:Retrospective Studies