[Measurement of peripapillary nerve fiber layer thickness at different distances from the optic nerve head with OCT].
OBJECTIVE
The aim of this study was to assess which distance to the optic nerve head is most favorable for circular measurements of retinal nerve fiber layer thickness (RNFLT) with OCT to detect differences between glaucoma and normal subjects.


METHODS
A total of 98 eyes of 67 subjects (normal subjects and POAG patients) were examined by Stratus OCT (Zeiss, Model 3000, Software Version 2.0). Images were scanned in the "proportional circle" mode and analyzed with the "RNFL thickness analysis" protocol. For statistical analysis the Friedman test and the Mann-Whitney U test with Bonferroni correction were used.


RESULTS
For 23 normal and 19 eyes of POAG patients a complete set of scans could be analyzed by the OCT software. RNFLT was statistically significantly different in scan diameters in both groups (P=0.000). Differences between the groups were statistically significant for the 1.0-fold (P=0.003), for the 1.4-fold (P=0.01), and for the 1.8-fold (P=0.002) disc diameter.


CONCLUSIONS
Circular scans with a 1-fold and with a 1.8-fold disc diameter seem to be able to differentiate best between glaucoma and normal subjects.
Böhm
A G
AG
Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Carl Gustav Carus, Dresden. boehm@uniklinikum-dresden.de
Schmidt
E
E
Müller-Holz
M
M
Pillunat
L E
LE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology; D012016:Reference Values; D012160:Retina / Q000473:pathology*; D012984:Software; D041623:Tomography, Optical Coherence