title: [Correlation between integrin subunits alpha5 and beta1 expressions in prostate cancer and its clinical implication].
abstract: OBJECTIVE
  To explore the correlation between the expression of integrin subunits alpha5 and beta1 in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage.
  
  
  METHODS
  Expressions of integrin subunits alpha5 and beta1 were examined in 30 cases of PCa and 30 cases of normal prostatic tissues by immunohistochemical assay.
  
  
  RESULTS
  Expressions of integrin subunits alpha5 and beta1 in PCa were lower than those in normal prostatic tissues (P <0.05) respectively.
  
  
  CONCLUSIONS
  Compared with normal prostatic tissues, expressions of integrin subunits alpha5 and beta1 in PCa were rather weaker or even faded. Expressions of integrin subunits alpha5 and beta1 revealed an positive correlation with tumor's Gleason grade and negative with clinical TNM stage. The results indicate that integrin subunits alpha5 and beta1 have potential values in the diagnosis and are predictable indices in the proliferation of PCa.
authors.affiliation: Department of Urology, Zhongshan Hospital, School of Medicine, Fudan University, Shanghai 200032, China.
authors.forename: Hai-Jiao
authors.initials: HJ
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yong-Kang
authors.initials: YK
authors.lastname: Zhang
authors.forename: Guo-Min
authors.initials: GM
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D006801:Humans; D039482:Integrin alpha5 / Q000096:biosynthesis*; D039081:Integrin alpha5beta1 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009367:Neoplasm Staging; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D039482:Integrin alpha5; D039081:Integrin alpha5beta1