title: Extensive chronic graft-versus-host disease of skin successfully treated with thalidomide.
abstract: Thirty years female underwent allogenic peripheral blood stem cell transplantation for chronic myeloid leukaemia--chronic phase. She developed grade II acute skin graft-versus-host disease (GVHD) which was treated with cyclosporine and a short course of steroids. She developed extensive chronic GVHD of the skin and liver three hundred days post-transplant. She was managed with the standard immunosuppressants with partial response of liver dysfunction but no response of skin lesions. She showed a good response to therapy with resolution of skin lesions after treatment with thalidomide.
authors.affiliation: Army Hospital (R & R), Delhi Cantt, New Delhi.
authors.forename: V
authors.initials: V
authors.lastname: Nair
authors.forename: A
authors.initials: A
authors.lastname: Sharma
authors.forename: I
authors.initials: I
authors.lastname: Ghosh
authors.forename: S
authors.initials: S
authors.lastname: Arora
authors.forename: Kavita
authors.initials: K
authors.lastname: Sahai
authors.forename: Vibha
authors.initials: V
authors.lastname: Dutta
mesh_terms: D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012871:Skin Diseases / Q000188:drug therapy*; D013792:Thalidomide / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide