title: Bacteriophages and transplantation tolerance.
abstract: Our recent findings suggest that bacteriophages (phages) may not only eliminate bacteria, but also modulate immune functions. In this communication, we demonstrate that phages may strongly inhibit human T-cell activation and proliferation as well as activation of the nuclear transcription factor NF-kappaB in response to a viral pathogen. Phage administration in vivo can diminish cellular infiltration of allogeneic skin allografts. Thus, phage treatment should be considered in antibiotic-resistant posttransplantation infections. Furthermore, phages could find a broader application in clinical transplantation.
authors.affiliation: Transplantation Institute, Warsaw Medical University, 02-006 Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Górski
authors.forename: M
authors.initials: M
authors.lastname: Kniotek
authors.forename: A
authors.initials: A
authors.lastname: Perkowska-Ptasińska
authors.forename: A
authors.initials: A
authors.lastname: Mróz
authors.forename: A
authors.initials: A
authors.lastname: Przerwa
authors.forename: W
authors.initials: W
authors.lastname: Gorczyca
authors.forename: K
authors.initials: K
authors.lastname: Dabrowska
authors.forename: B
authors.initials: B
authors.lastname: Weber-Dabrowska
authors.forename: M
authors.initials: M
authors.lastname: Nowaczyk
mesh_terms: D000818:Animals; D001435:Bacteriophages / Q000276:immunology* / Q000302:isolation & purification*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D016038:Skin Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D023001:Transplantation Tolerance / Q000276:immunology*