Salivary gland gene therapy.
Salivary glands have proven to be unusual but valuable target sites for multiple clinical gene transfer applications. Access to salivary glands for gene transfer is easy. Multiple studies in animal models have yielded proofs of concept for novel treatments for damaged salivary glands following therapeutic irraditation, in Sjögren's syndrome, and for gene therapeutics systemically by way of the blood-stream and locally in the oral cavity and upper gastrointestinal tract.
Cotrim
Ana P
AP
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1190, USA.
Mineshiba
Fumi
F
Sugito
Takayuki
T
Samuni
Yuval
Y
Baum
Bruce J
BJ
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006258:Head and Neck Neoplasms / Q000150:complications / Q000532:radiotherapy; D006801:Humans; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D011832:Radiation Injuries / Q000628:therapy; D051381:Rats; D012466:Salivary Gland Diseases / Q000150:complications / Q000628:therapy*; D012469:Salivary Glands / Q000293:injuries / Q000378:metabolism*; D012859:Sjogren's Syndrome / Q000235:genetics / Q000628:therapy
D011506:Proteins