Prolonged cholestasis associated with short-term use of celecoxib.
Drug-induced liver injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported. We describe one case of severe and prolonged cholestasis after treatment with celecoxib for 12 days in a young woman with no evidence of other causes of liver disease or allergy. Jaundice lasted for 3 months, pruritus and abnormal liver biochemistry persisted for 18 months after stopping the drug. Liver biopsy specimens showed a cholestatic pattern of liver injury with only minimal mononuclear infiltrate in the portal tracts. This case report supports the notion that celecoxib may cause bland, long term cholestasis.
Chamouard
Patrick
P
Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpital de Hautepierre. Patrick.Chamouard@chru-strasbourg.fr
Walter
Paul
P
Baumann
René
R
Poupon
Raoul
R
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000068579:Celecoxib; D002779:Cholestasis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000139:chemically induced; D010149:Postoperative Pain / Q000188:drug therapy; D011720:Pyrazoles / Q000008:administration & dosage / Q000009:adverse effects*; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib