title: Antimitotic agents of natural origin.
abstract: Antimitotic agents have been the most successful pharmacological agents for the treatment of cancer. The term "antimitotic agent" has traditionally been synonymous with tubulin-targeting compounds, but as a consequence of the large number of new compounds and mechanisms that have been identified recently, a much broader definition is currently needed. This review attempts to provide a broad overview of compounds and their cognate protein targets which result in a block in mitosis. Focus has been placed on agents that act directly on the mitotic machinery rather than on targets further upstream such as growth factor receptors.
authors.affiliation: Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.
authors.forename: Advait
authors.initials: A
authors.lastname: Nagle
authors.forename: Wooyoung
authors.initials: W
authors.lastname: Hur
authors.forename: Nathanael S
authors.initials: NS
authors.lastname: Gray
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D050256:Antimitotic Agents / Q000145:classification / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D001688:Biological Products / Q000145:classification / Q000494:pharmacology*; D003078:Colchicine / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D016547:Kinesins / Q000037:antagonists & inhibitors; D008868:Microtubule Proteins / Q000037:antagonists & inhibitors; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors / Q000235:genetics; D061988:Proteasome Inhibitors; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D059003:Topoisomerase Inhibitors; D014404:Tubulin / Q000187:drug effects; D014748:Vinca Alkaloids / Q000494:pharmacology
chemical_list: D000199:Actins; D050256:Antimitotic Agents; D001688:Biological Products; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D008868:Microtubule Proteins; D061988:Proteasome Inhibitors; D013438:Sulfhydryl Compounds; D059003:Topoisomerase Inhibitors; D014404:Tubulin; D014748:Vinca Alkaloids; D010744:Phosphoric Monoester Hydrolases; D016547:Kinesins; D003078:Colchicine