A one-pot entry to a novel 3-H-benzo[d]pyrazolo[1,5-b]isothiazole ring system.
The phosphorus ylide obtained from the reaction between 2-aminobenzo[d]isothiazol-3-one and dimethyl acetylenedicarboxylate in the presence of triphenylphosphine undergoes a smooth intramolecular Wittig-type reaction to produce, in a one-pot reaction, 3-H-benzo[d]pyrazolo[1,5-b]isothiazole-2,3a-dicarboxylic acid dimethyl ester, a novel functionalized heterocyclic compound.
Vicini
Paola
P
Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43100, Parma, Italy. paola.vicini@unipr.it
Incerti
Matteo
M
Ferretti
Rocco
R
Zanardi
Franca
F
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D000480:Alkynes; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
D000480:Alkynes; D006571:Heterocyclic Compounds; D009943:Organophosphorus Compounds; D013844:Thiazoles; C061896:triphenylphosphine; C022918:acetylenedicarboxylic acid dimethyl ester; D000114:Acetylene