[Total antioxidant capacity of blood plasma in healthy men and in men with coronary heart disease].
BACKGROUND
The aim of the study was to determine the level of total antioxidant capacity (TAC) of blood plasma in healthy men and in men with coronary heart disease differentiated by their level of physical activity.


METHODS
The study was carried out in the two groups of age-adjusted men. Group I comprised 100 healthy men aged 56.6 +/- 8.5 years and group II involved 100 men with identified coronary heart disease aged 56.6 +/- 7.2 years. BMI was determined in every participant. Level of energy expediture was determined by calculating the amount of hours per week spent for different recreational sports activities. Spectrophotometric method FRAP (Ferric Reducing Ability of Plasma) was applied to estimate total antioxidant capacity of blood plasma.


RESULTS
Values of absorbance describing level of total antioxidant capacity of blood plasma in 1', 3' and 10' minut of reaction time window differed between groups. Men with coronary heart disease were characterised by higher antioxidant defense system than healthy ones. Energy expediture expressed in kcal per week was statistically higher in healthy subjects. In healthy men positive correlation was found between level of total antioxidant capacity (in 1', 3' and 10' minut of reaction time window) and BMI (p< or = 0.05). Statistically significant negative correlation was found for TAC and level of energy expediture. Among men with coronary heart disease there was statistically significant positive correlation between the values of total antioxidant capacity (in 1', 3' and 10' minut of reaction time window) and BMI. There was no statistically significant correlation neither between age and TAC, nor between energy expediture and TAC.


CONCLUSIONS
The level of total antioxidant capacity estimated with FRAP method was higher in men with coronary heart disease in comparison with healthy men. Antioxidant potential was higher along with the increase of BMI in both groups. Increased energy expenditure was related to decreased total antioxidant capacity, but only in healthy men.
Gawron
Anna
A
Zakład Medycyny Zapobiegawczej Uniwersytet Medyczny w Lodzi.
Chrzczanowicz
Jacek
J
Nowak
Dariusz
D
Nonas
Monika
M
Drygas
Wojciech
W
Jegier
Anna
A
Kostka
Tomasz
T
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood*; D004734:Energy Metabolism; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged
D000975:Antioxidants