title: Endocarditis and pericarditis complicating pneumococcal bacteraemia, with special reference to the adhesive abilities of pneumococci: results from a prospective study.
abstract: The incidence of pneumococcal cardiac infections is unknown and the pathogenicity of such complications is poorly understood. In a prospective, international, observational study, eight of 844 patients hospitalised with Streptococcus pneumoniae bacteraemia developed endocarditis (n = 5) or pericarditis (n = 3). The clinical and microbiological characteristics of these patients were compared with those of control patients. The corresponding incidence of pneumococcal endocarditis was c. 1-3/1 million inhabitants/year. There was no common pattern in the medical history of patients with an infectious cardiac complication. The severity of illness upon admission was comparable with that for patients without infectious cardiac complications, as was the 14-day mortality rate (25% and 17%, respectively). For encapsulated S. pneumoniae, no significant differences were found between patients with infectious cardiac complications and controls in adherence assays. However, non-encapsulated S. pneumoniae showed higher hydrophobicity and increased adherence to human epithelial cells.
authors.affiliation: Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Kan
authors.forename: J
authors.initials: J
authors.lastname: Ries
authors.forename: B Henriques
authors.initials: BH
authors.lastname: Normark
authors.forename: F-Y
authors.initials: FY
authors.lastname: Chang
authors.forename: C
authors.initials: C
authors.lastname: Feldman
authors.forename: W C
authors.initials: WC
authors.lastname: Ko
authors.forename: J
authors.initials: J
authors.lastname: Rello
authors.forename: D R
authors.initials: DR
authors.lastname: Snydman
authors.forename: V L
authors.initials: VL
authors.lastname: Yu
authors.forename: A
authors.initials: A
authors.lastname: Ortqvist
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000150:complications* / Q000453:epidemiology; D001422:Bacterial Adhesion; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010493:Pericarditis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013296:Streptococcus pneumoniae / Q000302:isolation & purification / Q000472:pathogenicity*