Expression of HER1/EGFR protein in human soft tissue sarcomas.
OBJECTIVE
To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples.


METHODS
HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients.


RESULTS
HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues.


CONCLUSIONS
HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.
Yang
J-L
JL
Oncology Research Centre, School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. j.yang@unsw.edu.au
Hannan
M T
MT
Russell
P J
PJ
Crowe
P J
PJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology; D012720:Severity of Illness Index
D014408:Biomarkers, Tumor; D066246:ErbB Receptors