[Expression and implication of cyclooxygenase-2 mRNA in prostate cancer].
OBJECTIVE
To investigate the relationship between cyclooxygenase-2 (COX-2) mRNA expression and the biological behaviors of prostate carcinoma (PCa).


METHODS
The expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined. Seven normal prostate tissues were served as control.


RESULTS
The expression of COX-2 mRNA in normal tissue of 7 control cases was all negative. There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa. There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.


CONCLUSIONS
COX-2 mRNA play an important role in occurrence and progression of the PCa. COX-2 is a tumor marker which may be the possible prognostic factor of PCa.
Yang
Ming-Shan
MS
Department of Urology, the First Hospital of Shanghai Jiaotong University, Shanghai 200080, China. yangmingshandachuan@126.com
Xia
Shu-Jie
SJ
Liu
Hai-Tao
HT
Sun
Xiao-Wen
XW
Han
Bang-Min
BM
Wu
Ji-Tao
JT
Lu
Jun
J
Ling
Gui-Ming
GM
Tang
Xiao-Da
XD
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D012333:RNA, Messenger; D051546:Cyclooxygenase 2