title: High-sensitivity C-reactive protein and parameters of left ventricular dysfunction.
abstract: BACKGROUND
  Elevated levels of high-sensitivity C-reactive protein (CRP), an inflammatory marker, have been associated with heart failure. However, it is not known which parameters of left ventricular dysfunction correlate with elevated levels of CRP.
  
  
  RESULTS
  In this cross-sectional study of 98 patients referred for cardiac catheterization, we investigated whether commonly used clinical indices of left ventricular dysfunction correlated with CRP levels. CRP levels were elevated to a greater degree in participants with diabetes mellitus (P =.006) and heart failure (P =.003). Increased CRP levels were associated with increased plasma levels of B-type natriuretic peptide (BNP; P =.0001), decreased left ventricular ejection fraction (LVEF; P =.02), and increased left-ventricular end-diastolic pressure (LVEDP; P =.0005). After multivariable adjustment, LVEDP and CRP were independently associated (P =.046).
  
  
  CONCLUSIONS
  CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP.
authors.affiliation: Division of Cardiology, Department of Medicine, University of California, San Francisco, 94143, USA.
authors.forename: Sanjiv J
authors.initials: SJ
authors.lastname: Shah
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Marcus
authors.forename: Ivor L
authors.initials: IL
authors.lastname: Gerber
authors.forename: Barry H
authors.initials: BH
authors.lastname: McKeown
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Vessey
authors.forename: Mark V
authors.initials: MV
authors.lastname: Jordan
authors.forename: Michele
authors.initials: M
authors.lastname: Huddleston
authors.forename: Elyse
authors.initials: E
authors.lastname: Foster
authors.forename: Kanu
authors.initials: K
authors.lastname: Chatterjee
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Michaels
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003971:Diastole; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011446:Prospective Studies; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000503:physiopathology*; D017725:Ventricular Pressure
chemical_list: D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein