Histamine in cardiac sympathetic ganglia: a novel neurotransmitter?
Although ganglia in the heart are well known to be cholinergic, many other neurotransmitters and neuropeptides also influence (and are produced in) cardiac neurons, including adrenergic and purinergic compounds. Recently, histamine was suggested as a possible neurotransmitter in cardiac tissue. Although histamine does elicit many effects in the heart, does it stand up to rigorous scrutiny and fulfill certain criteria that are used to define neurotransmitters?
Fryer
Ryan M
RM
Department of Integrative Pharmacology, Abbott Laboratories, Abott Park, IL 60064-6119, USA. ryan.fryer@abbott.com
Reinhart
Glenn A
GA
Esbenshade
Timothy A
TA
D005728:Ganglia, Sympathetic / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*
D018377:Neurotransmitter Agents; D006632:Histamine