title: Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice.
abstract: Mice infected with reovirus develop abnormalities in glucose homeostasis. Reovirus strain type 3 Abney (T3A) was capable of systemic infection of nonobese diabetic (NOD) mice, an experimental model of autoimmune diabetes. Reovirus antigen was detected in pancreatic islets of T3A-infected mice, and primary cultures of pancreatic islets from NOD mice supported T3A growth. Significantly fewer T3A-infected animals compared to uninfected controls developed diabetes. However, despite the alteration in diabetes penetrance, insulitis was evident in T3A-infected mice. These results suggest that viral infection of NOD mice alters autoimmune responses to beta-cell antigens and thereby delays development of diabetes.
authors.affiliation: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
authors.forename: J Denise
authors.initials: JD
authors.lastname: Wetzel
authors.forename: Erik S
authors.initials: ES
authors.lastname: Barton
authors.forename: James D
authors.initials: JD
authors.lastname: Chappell
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Baer
authors.forename: Michelle
authors.initials: M
authors.lastname: Mochow-Grundy
authors.forename: Steven E
authors.initials: SE
authors.lastname: Rodgers
authors.forename: Yu
authors.initials: Y
authors.lastname: Shyr
authors.forename: Alvin C
authors.initials: AC
authors.lastname: Powers
authors.forename: James W
authors.initials: JW
authors.lastname: Thomas
authors.forename: Terence S
authors.initials: TS
authors.lastname: Dermody
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000276:immunology* / Q000503:physiopathology*; D005260:Female; D007515:Islets of Langerhans / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D012089:Mammalian orthoreovirus 3 / Q000472:pathogenicity*; D051379:Mice; D016688:Mice, Inbred NOD / Q000821:virology; D010182:Pancreatic Diseases / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D012088:Reoviridae Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology