New insecticidal antibiotics, hydroxyfungerins A and B, produced by Metarhizium sp. FKI-1079.
New insecticidal antibiotics designated hydroxyfungerins A and B were isolated from the culture broth of a fungal strain Metarhizium sp. FKI-1079 together with a known compound, fungerin. The structures of hydroxyfungerins A and B were elucidated by spectroscopic studies including various NMR experiments. Hydroxyfungerins A and B showed growth inhibitory activity against brine shrimps, Artemia salina.
Uchida
Ryuji
R
School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Imasato
Rie
R
Yamaguchi
Yuichi
Y
Masuma
Rokuro
R
Shiomi
Kazuro
K
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D000969:Antinematodal Agents / Q000494:pharmacology; D001156:Artemia; D001203:Ascomycota / Q000145:classification / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007093:Imidazoles / Q000378:metabolism* / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011422:Propionates / Q000378:metabolism* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D007093:Imidazoles; D007306:Insecticides; D011422:Propionates; C508788:hydroxyfungerin A; C508789:hydroxyfungerin B