Diastereoselective synthesis of highly functionalized tetrahydroxanthenols--unprecedented access to privileged structural motifs.
Tetrahydroxanthenones, which can be easily prepared by a domino oxa-Michael aldol condensation, offer various possibilities for diastereoselective functionalization, giving access to the stereocontrolled synthesis of stereochemical triades or tetrades, which represent privileged structural motifs. In most cases, the relative stereochemistry was unequivocally established by crystal structure analysis.
Nising
Carl F
CF
Institut für Organische Chemie, Universität Karlsruhe TH, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
Ohnemüller
Ulrike K
UK
Friedrich
Anne
A
Lesch
Bernhard
B
Steiner
Jochen
J
Schnöckel
Hansgeorg
H
Nieger
Martin
M
Bräse
Stefan
S
D000447:Aldehydes / Q000737:chemistry; D002621:Chemistry / Q000379:methods*; D018360:Crystallography, X-Ray; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism; D014966:Xanthenes / Q000737:chemistry*
D000447:Aldehydes; D006575:Heterocyclic Compounds, 3-Ring; D014966:Xanthenes; C116609:3-hydroxybutanal