title: Tracing the origin of Brazilian HTLV-1 as determined by analysis of host and viral genes.
abstract: We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu-Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence rate in KZN was 1.7%. All sequences belonged to the A subgroup. The presence of South African sequences in two different clusters from Brazil, and the finding of the beta-globin haplotype in infected hosts are consistent with the transmission of this virus from southern Africa to Brazil.
authors.affiliation: Public Health Advanced Laboratory, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
authors.forename: Luiz C J
authors.initials: LC
authors.lastname: Alcantara
authors.forename: Tulio
authors.initials: T
authors.lastname: de Oliveira
authors.forename: Michelle
authors.initials: M
authors.lastname: Gordon
authors.forename: Oliver
authors.initials: O
authors.lastname: Pybus
authors.forename: Rita Elizabeth
authors.initials: RE
authors.lastname: Mascarenhas
authors.forename: Magda O
authors.initials: MO
authors.lastname: Seixas
authors.forename: Marilda
authors.initials: M
authors.lastname: Gonçalves
authors.forename: Carol
authors.initials: C
authors.lastname: Hlela
authors.forename: Sharon
authors.initials: S
authors.lastname: Cassol
authors.forename: Bernardo
authors.initials: B
authors.lastname: Galvão-Castro
mesh_terms: D001938:Brazil / Q000453:epidemiology; D019143:Evolution, Molecular; D005814:Genes, Viral; D014644:Genetic Variation; D005914:Globins / Q000235:genetics; D015490:HTLV-I Infections / Q000453:epidemiology / Q000235:genetics*; D006239:Haplotypes; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods; D010802:Phylogeny; D016036:Seroepidemiologic Studies; D013019:South Africa; D020079:Terminal Repeat Sequences
chemical_list: D005914:Globins