title: The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer.
abstract: The relationship between tumour stage, grade (Fuhrman), performance status (ECOG), a combined score (UCLA Integrated Staging System, UISS), systemic inflammatory response (elevated C-reactive protein concentration), and cancer-specific survival was examined in patients undergoing potentially curative resection for renal clear cell cancer (n=100). On univariate survival analysis, sex (P=0.050), tumour stage (P=0.001), Fuhrman grade (P<0.001), UISS (P<0.001), C-reactive protein (P=0.002) were significant predictors of survival. On multivariate analysis with sex, UISS and C-reactive protein entered as covariates, only UISS (HR 2.70, 95% CI 1.00-7.30, P=0.050) and C-reactive protein (HR 4.00, 95% CI 1.21-13.31, P=0.024) were significant independent predictors of survival. The presence of a preoperative systemic inflammatory response predicts poor cancer-specific survival in patients who have undergone potentially curative resection for renal clear cell cancer.
authors.affiliation: Department of Urology, Gartnavel General Hospital, Glasgow G12 0YN, UK.
authors.forename: G W A
authors.initials: GW
authors.lastname: Lamb
authors.forename: D C
authors.initials: DC
authors.lastname: McMillan
authors.forename: S
authors.initials: S
authors.lastname: Ramsey
authors.forename: M
authors.initials: M
authors.lastname: Aitchison
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007249:Inflammation; D007680:Kidney Neoplasms / Q000276:immunology* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D002097:C-Reactive Protein