5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.
Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.
Skorobogatyi
Mikhail V
MV
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
Ustinov
Alexei V
AV
Stepanova
Irina A
IA
Pchelintseva
Anna A
AA
Petrunina
Anna L
AL
Andronova
Valeriya L
VL
Galegov
Georgi A
GA
Malakhov
Andrei D
AD
Korshun
Vladimir A
VA
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D013053:Spectrophotometry
D000998:Antiviral Agents; D009705:Nucleosides; D003857:Deoxyuridine