Functional interactions of protein kinase A and C in signalling networks: a recapitulation.
On the basis of evidence collected from the literature, we propose a general model by which protein kinase (PK) A and the different PKC isoforms can inversely affect cell growth. Molecular switches, which are able to direct the signal towards antiproliferative or mitogenic pathways, are the different isoforms of Raf and PKC. Conflicting data are also reported and discussed in an attempt to reconcile them.
Maioli
E
E
Department of Physiology, University of Siena, via Aldo Moro 8, 53100, Siena, Italy. maioli@unisi.it
Torricelli
C
C
Fortino
V
V
D000818:Animals; D049109:Cell Proliferation; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D020033:Protein Isoforms / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D020033:Protein Isoforms; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C