Duration of effects of aspirin on platelet function in healthy volunteers: an analysis using the PFA-100.
OBJECTIVE
The aim of the study was to determine the duration and effects of aspirin on platelet function.


METHODS
Prospective investigation.


METHODS
Blood samples from volunteers. PATIENTS AND MONITORING: Ten healthy male volunteers took part in this investigation. After having measured baseline hemostatic parameters, 2000-mg aspirin was taken orally. Subsequently, the hemostatic profile had been compiled daily for a duration of 4 days after ingestion.


RESULTS
Platelet function was analyzed (1) after 3 hours and (2) daily for 4 days by the platelet function analyzer (PFA-100, Dade Co, Miami, Fla), which represents a sensitive investigation method for measuring platelet function and dysfunction. Routine hemostatic parameters were investigated. Three hours after ingestion of aspirin, abnormal PFA-100 values could be detected. Further detectable elevated values were found during the following 3 days.


CONCLUSIONS
Effects of single-dose aspirin 2000 mg on platelet function were detected after 3 hours and had been lasting for the following 3 days. This result shows that PFA-100 may help by evaluating hemostasis during the preoperative period.
Konrad
Christoph J
CJ
Clinical Pain Research and Pain Clinics, Institute of Anesthesiology and Intensive Care Medicine, University Clinics Mannheim, Ruprecht Karls-University of Heidelberg, 68167 Mannheim, Germany. christoph.konrad@anaes.ma.uni-heidelberg.de
Schuepfer
Guido K
GK
Gerber
Helmut
H
Rukwied
Roman
R
Schmelz
Martin
M
Schley
Marcus
M
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010979:Platelet Function Tests / Q000295:instrumentation*; D012680:Sensitivity and Specificity
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; D004837:Epinephrine