Multicolor quantum dots for molecular diagnostics of cancer.
In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.
Smith
Andrew M
AM
Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA.
Dave
Shivang
S
Nie
Shuming
S
True
Lawrence
L
Gao
Xiaohu
X
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D019295:Computational Biology / Q000379:methods; D023281:Genomics; D006801:Humans; D036103:Nanotechnology; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D045663:Quantum Dots; D012680:Sensitivity and Specificity
D015415:Biomarkers