Hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage.
Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3-6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.
Nishihashi
Tsuyoshi
T
Pharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, Japan.
Trandafir
Cristina C
CC
Wang
Aimin
A
Ji
Xu
X
Shimizu
Yoshiharu
Y
Kurahashi
Kazuyoshi
K
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects* / Q000503:physiopathology; D017665:Hydroxyl Radical / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D013997:Time Factors; D014661:Vasoconstriction
D017665:Hydroxyl Radical