Mild organocatalytic alpha-methylenation of aldehydes.
A rapid and extremely convenient method for alpha-methylenation of aldehydes with aqueous formaldehyde is described. Two optimal catalytic systems are presented that allow short reaction times and afford the functionalized products in good to excellent yields (up to 99%) and chemoselectivity.
Erkkilä
Anniina
A
Laboratory of Organic Chemistry, Helsinki University of Technology, P.O.B. 6100, FI-02015 TKK, Finland.
Pihko
Petri M
PM
D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D008745:Methylation; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D000588:Amines