title: Predicted and measured disorder in peripherin/rds, a retinal tetraspanin.
abstract: Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this protein's C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short C-termini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.
authors.affiliation: Eye Research Institute, Oakland University, Rochester, MI 48309, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Ritter
authors.forename: T
authors.initials: T
authors.lastname: Arakawa
authors.forename: A F X
authors.initials: AF
authors.lastname: Goldberg
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D015870:Gene Expression / Q000235:genetics; D057927:Hydrophobic and Hydrophilic Interactions; D007381:Intermediate Filament Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D064531:Peripherins; D018583:Pliability; D011489:Protein Denaturation; D012160:Retina / Q000737:chemistry*; D012995:Solubility; D014461:Ultracentrifugation
chemical_list: D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D064531:Peripherins