An alkoxide-directed carbometalation of internal alkynes.
A mild and efficient alkoxide-directed carbometalation is described. Regioselective carbon-carbon bond formation occurs in all cases at the site distal to the tethered alkoxide. This reaction provides a convenient means to prepare differentially functionalized tetrasubstituted 1,3-dienes in a regio- and stereoselective manner.
Ryan
Jamie
J
Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA.
Micalizio
Glenn C
GC