title: Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis.
abstract: The presence of gene polymorphisms of the estrogen receptors ERalpha (PvuII and XbaI) and ERbeta (AluI) in 61 women with endometriosis was investigated. A statistically significant correlation between PvuII ERalpha gene polymorphism (PvuII), both in homozygosity (PP) and in heterozygosity (Pp), and a recurrence of endometriosis was found. In conclusion, women affected by endometriosis with the ERalpha polymorphic allele, even if heterozygous, have a worse prognosis, and these results suggest that the ERalpha gene polymorphisms may be included among the genetic risk factors for endometriosis.
authors.affiliation: Department of Pediatrics, Gynecology and Reproductive Medicine, University of Siena, Siena, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Luisi
authors.forename: Letizia
authors.initials: L
authors.lastname: Galleri
authors.forename: Francesca
authors.initials: F
authors.lastname: Marini
authors.forename: Guido
authors.initials: G
authors.lastname: Ambrosini
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Brandi
authors.forename: Felice
authors.initials: F
authors.lastname: Petraglia
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D012008:Recurrence
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta