title: Lymphoplasmacytic infiltration of multiple organs with immunoreactivity for IgG4: IgG4-related systemic disease.
abstract: We report three elderly men with high serum IgG4 concentrations and multiple lymphoplasmacytic inflammation of the salivary glands, lymph nodes, pancreas, and renal interstitium. The infiltrating plasma cells had strong immunoreactivity for IgG4, even in patients without pancreatic lesions. These cases show that IgG4 is associated not only with autoimmune pancreatitis, but also with other systemic lymphoplasmacytic disease.
authors.affiliation: Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka.
authors.forename: Takako
authors.initials: T
authors.lastname: Saeki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saito
authors.forename: Tohru
authors.initials: T
authors.lastname: Hiura
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Iwao
authors.initials: I
authors.lastname: Emura
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ueno
authors.forename: Syoji
authors.initials: S
authors.lastname: Miyamura
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007668:Kidney / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology
chemical_list: D007074:Immunoglobulin G