Rat genetics: the next episode.
More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human disease have been identified in a wide range of rat inbred lines over the past few decades. With the complete rat genome available, it is now time for the next stage in rat genetic research: the identification and causal confirmation of underlying polymorphisms and genes. Recent developments in single nucleotide polymorphism-based genetic markers and technologies to manipulate the rat genome will undoubtedly be important tools in this next episode.
Smits
Bart M G
BM
Functional Genomics Group, Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Cuppen
Edwin
E
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D005038:Ethylnitrosourea / Q000494:pharmacology; D020868:Gene Silencing; D036281:Genetic Research; D005821:Genetic Techniques / Q000639:trends; D006801:Humans; D016296:Mutagenesis; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D034741:RNA, Small Interfering; D051381:Rats / Q000235:genetics*; D011995:Recombination, Genetic
D034741:RNA, Small Interfering; D005038:Ethylnitrosourea