Urodilatin excretion and its correlation with sodium excretion in healthy full-term newborn infants.
BACKGROUND
Urodilatin (URO) is a member of the natriuretic family, cleaved by the kidney, which acts as a paracrine hormone in the regulation of natriuresis and diuresis. In newborn infants the excretion of urodilatin and its biological effects have not been explored.


METHODS
We measured urinary URO excretion, by direct RIA (radioimmunoassay), as well as its correlation to neonatal body weight loss, and sodium homeostasis in 30 full-term newborn infants on the 4th day of life.


RESULTS
The URO excretion, estimated as URO:creatinine ratio, was significantly correlated to sodium excretion.


CONCLUSIONS
These data show that in full-term newborn infants the mechanisms that control synthesis, excretion and signal transduction of URO are developed and that URO contributes to natriuresis regulation.
Manganaro
Rosa
R
Department of Paediatric and Surgery Science, Division of Neonatology, University of Messina, 98100 Messina, Italy.
Mamì
Carmelo
C
Mancuso
Alba
A
Saitta
Giuseppe
G
Marseglia
Lucia
L
Gemelli
Marina
M
D001034:Apgar Score; D009320:Atrial Natriuretic Factor / Q000502:physiology / Q000652:urine*; D001835:Body Weight; D003404:Creatinine / Q000097:blood / Q000652:urine; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D009318:Natriuresis / Q000502:physiology*; D010446:Peptide Fragments / Q000502:physiology / Q000652:urine; D012964:Sodium / Q000652:urine*; D015431:Weight Loss
D010446:Peptide Fragments; C056452:Ularitide; D009320:Atrial Natriuretic Factor; D012964:Sodium; D003404:Creatinine