title: Safety limit of the extent of hepatectomy for rats with moderately fatty liver: experimental study concerning living liver donor safety.
abstract: BACKGROUND
  The aim of the present study was to determine whether rats with moderately fatty liver could withstand a 90% hepatectomy, which rats with normal livers can survive.
  
  
  METHODS
  Nine-week-old male Wistar rats were used. Normal rat chow was fed to the normal liver group, and fat-enriched rat chow was fed to the fatty liver group for 4 weeks to induce a moderately fatty liver. The authors have previously reported that this fatty liver rat model can cause fatal liver dysfunction after reduced-size-liver transplantation. A 90% and 95% hepatectomy were performed using rats of both groups to evaluate posthepatectomized liver function.
  
  
  RESULTS
  All rats undergoing a 90% hepatectomy were still alive 30 days after the hepatectomy, but the rats that underwent a 95% hepatectomy were all dead within 4 days regardless of group. Increases in the liver remnant wet weight measured until 7 postoperative days after 90% hepatectomy were almost similar among the two groups. Alanin aminotransferase measured at 24, 48, 72, and 168 h after a 90% hepatectomy were significantly higher in the fatty liver group than in the normal liver group. Similarly, at up to 72 h postoperatively, the serum hyarulonic acids were significantly higher in the fatty liver group.
  
  
  CONCLUSIONS
  A moderately fatty liver did not cause mortality in 90% hepatectomized rats. However, it caused a higher degree of hepatic parenchymal as well as sinusoidal injury.
authors.affiliation: Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa, Yokohama, Japan. dmorioka@hotmail.com
authors.forename: Daisuke
authors.initials: D
authors.lastname: Morioka
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hirochika
authors.initials: H
authors.lastname: Makino
authors.forename: Shuji
authors.initials: S
authors.lastname: Saito
authors.forename: Michio
authors.initials: M
authors.lastname: Ueda
authors.forename: Toru
authors.initials: T
authors.lastname: Kubota
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sekido
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Matsuo
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo
authors.forename: Shinji
authors.initials: S
authors.lastname: Togo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimada
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000097:blood / Q000401:mortality / Q000601:surgery*; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods* / Q000401:mortality; D006820:Hyaluronic Acid / Q000097:blood; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006820:Hyaluronic Acid; D000637:Transaminases