title: Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation.
abstract: We report the clinicopathological findings of astroblastoma found in an 8-year-old girl who was subsequently treated for 11 years. The primary superficially circumscribed tumor was located in the frontoparietal lobe, while the recurrent and the second recurrent tumor were restricted to the same region 11 years later. The tumors obtained on these three occasions showed fundamentally the same histological, immunohistochemical and fine structural features. They exhibited astrocytic as well as ependymal tanycytic features with apparent epithelial cell lineage. The tumor cells showed typical features of astroblastoma comprising prominent perivascular pseudorosettes with remarkable vascular sclerosis. The immunohistochemical study revealed intensive positivity of GFAP, vimentin, epithelial membrane antigen (EMA), cytokeratin, connexin 26 and 32, desmocollin 1 and neuronal cadherin. The fine structure revealed divergent types of junctional complexes, some of which were connected with tonofilament bundles. Numerous microvilli protruded and basal lamina abutted on the tumor cell surface. We report these unique histological features, and stress that astroblastoma should be categorized as a specific type of neuroepithelial tumor.
authors.affiliation: Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Matsuoka-Cho, Yoshida-Gun, Fukui, Japan. tkubott@fmsrsa.fukui-med.ac.jp
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kubota
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Sato
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Arishima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Kitai
authors.forename: Takao
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D019070:Cell Lineage; D002648:Child; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005910:Glioma / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D046529:Microscopy, Electron, Transmission; D018302:Neoplasms, Neuroepithelial / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D014408:Biomarkers, Tumor