Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11.
The development of T cell-based immunotherapies of cancer depends on the identification of tumor-associated antigens capable of eliciting tumor-directed cytotoxic T cell responses. In malignant glioma the number of well-defined target antigens for cytotoxic T lymphocytes (CTLs) is still very limited. Recently, we demonstrated the abundant and specific overexpression of the transcription factor SOX11 in malignant glioma. Here, we describe the SOX11-derived peptide LLRRYNVAKV which is capable of inducing human leukocyte antigen-A*0201-restricted and tumor-reactive CTLs. This novel CTL epitope may serve as an attractive candidate for a T cell-based immunotherapy of glioma.
Schmitz
Marc
M
Medical Faculty, Institute of Immunology, Technical University of Dresden, Fetscherstr. 74, 01307 Dresden, Germany. mschmitz@rcs.urz.tu-dresden.de
Wehner
Rebekka
R
Stevanovic
Stefan
S
Kiessling
Andrea
A
Rieger
Michael A
MA
Temme
Achim
A
Bachmann
Michael
M
Rieber
E Peter
EP
Weigle
Bernd
B
D000595:Amino Acid Sequence; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology*; D005910:Glioma / Q000276:immunology* / Q000473:pathology; D015234:HLA-A Antigens / Q000276:immunology; D015789:HLA-A2 Antigen; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D020014:K562 Cells; D008970:Molecular Weight; D009842:Oligopeptides / Q000737:chemistry / Q000276:immunology; D055751:SOXC Transcription Factors
D018984:Epitopes, T-Lymphocyte; D015234:HLA-A Antigens; C435939:HLA-A*02:01 antigen; D015789:HLA-A2 Antigen; D006609:High Mobility Group Proteins; D009842:Oligopeptides; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors