title: Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents.
abstract: An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH(4)Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels.
authors.affiliation: Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, SP, Brazil. hstefani@usp.br
authors.forename: Hélio A
authors.initials: HA
authors.lastname: Stefani
authors.forename: Carlindo B
authors.initials: CB
authors.lastname: Oliveira
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Almeida
authors.forename: Claudio M P
authors.initials: CM
authors.lastname: Pereira
authors.forename: Rodolpho C
authors.initials: RC
authors.lastname: Braga
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cella
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Borges
authors.forename: Lucielli
authors.initials: L
authors.lastname: Savegnago
authors.forename: Cristina W
authors.initials: CW
authors.lastname: Nogueira
mesh_terms: D000643:Ammonium Chloride; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010544:Peroxidases / Q000037:antagonists & inhibitors; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D014465:Ultrasonics
chemical_list: D000975:Antioxidants; D007202:Indicators and Reagents; D011744:Pyrimidinones; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D000643:Ammonium Chloride; D010544:Peroxidases; D005978:Glutathione