Genome-wide approaches to identifying genetic factors in host susceptibility to tuberculosis.
Host genetic factors are important in determining susceptibility to Mycobacterium tuberculosis. Genome-wide linkage studies have been performed in humans and in murine models of tuberculosis susceptibility. These studies have identified several important candidate loci for susceptibility to tuberculosis. This is an important step in resolving the complex etiology of the disease.
Bellamy
Richard
R
Department of Infection and Travel Medicine, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK. richard.bellamy@stees.nhs.uk
D000818:Animals; D002877:Chromosomes, Human / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D016678:Genome / Q000235:genetics; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D051379:Mice / Q000235:genetics; D014376:Tuberculosis / Q000209:etiology / Q000235:genetics*
D005819:Genetic Markers