Alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis.
One new prenylated 1,4-anthraquinone and three new prenylated anthranols, named kengaquinone (1) and kenganthranols A (2), B (3), and C (4), were isolated from a hexane extract of the stem bark of Harungana madagascariensis. Six known compounds including anthraquinones, anthrones, and xanthones were also isolated and identified. The structures of the new compounds were determined by analysis of spectroscopic data and comparison with data of previously known analogues. Some isolated compounds (3-5, 7-11) were evaluated for their alpha-glucosidase inhibition activity. Compounds 3, 4, 8, and 11 showed significant activity, whereas compounds 7, 9, and 10 were inactive in this test.
Kouam
Simeon F
SF
Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon.
Khan
Shamsun Nahar
SN
Krohn
Karsten
K
Ngadjui
Bonaventure T
BT
Kapche
Deccaux G W F
DG
Yapna
Diane B
DB
Zareem
Seema
S
Moustafa
Amal M Y
AM
Choudhary
M Iqbal
MI
D000875:Anthralin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D000520:alpha-Glucosidases / Q000032:analysis*
D000880:Anthraquinones; D004791:Enzyme Inhibitors; C508817:kenganthranol A; C508818:kenganthranol B; C508819:kenganthranol C; C508816:kengaquinone; D000520:alpha-Glucosidases; D000875:Anthralin