title: [Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives].
abstract: The biological activity of natural and semisynthetic lupane triterpenoids is discussed in a two-part review. The first part is devoted to the pharmacological properties of natural lupane triterpenoids. Betulinic acid has proven to be the most effective antitumor agent among more than fifty natural lupanes.
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
authors.forename: A G
authors.initials: AG
authors.lastname: Tolstikov
authors.forename: O B
authors.initials: OB
authors.lastname: Flekhter
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C480546:lupane; D000094062:Betulinic Acid