Treatment of primary progressive freezing of gait with high doses of selegiline.
We report the case of a 76-year-old, right-handed woman with progressive primary freezing of gait. Despite several therapeutic strategies, she continued to worsen to the point that she became confined to a wheelchair. Treatment with selegiline in doses up to 20 mg/d led to marked improvement of the gait disorder. This case illustrates that selegiline can be an option for patients with freezing of gait other than those with Parkinson's disease.
Zúñiga
Carlos
C
Parkinson's Disease and Movement Disorders Unit, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.
Lester
Jacobo
J
Cersósimo
María Graciela
MG
Díaz
Sergio
S
Micheli
Federico E
FE
D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects*; D020233:Gait Disorders, Neurologic / Q000188:drug therapy*; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012642:Selegiline / Q000627:therapeutic use*
D018696:Neuroprotective Agents; D012642:Selegiline