title: The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease.
abstract: Compelling evidence supports the importance of metabolic abnormalities in Alzheimer disease pathogenesis. Indeed, that oxidative mechanisms are involved in the neuropathology associated with Alzheimer disease is evidenced by the large number of metabolic signs of oxidative stress as well as by specific markers of oxidative damage. However, in the initial stages of disease development, neurons adapt to the oxidative environment through the development of compensatory responses resulting in a shift of neuronal priority from normal function to basic survival.
authors.affiliation: Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA.
authors.forename: Paula I
authors.initials: PI
authors.lastname: Moreira
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Lee
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Honda
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Perry
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*