title: Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide).
abstract: The in vitro antimalarial activity of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide) and their derivatives, against the Plasmodium falciparum FCR-3 strain (ATCC 30932, chloroquine-sensitive) was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 3.5microM to 10nM. The chain length of the N1-alkyl moiety was found to be very beneficial in terms of antimalarial activity, and in this series of compounds, the most appropriate N1-alkyl chain length was found to be eight.
authors.affiliation: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Kanji
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Daiki
authors.initials: D
authors.lastname: Morisaki
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Tetsuto
authors.initials: T
authors.lastname: Namba
authors.forename: Kim
authors.initials: K
authors.lastname: Hye-Sook
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Wataya
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kourai
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kakuta
authors.forename: Kenji
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D051379:Mice; D010963:Plasmodium falciparum / Q000187:drug effects; D011726:Pyridinium Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D011726:Pyridinium Compounds