title: [Experimental pathological study of acute intoxication by Chloranthus serratus Roem. Et Schalt].
abstract: OBJECTIVE
  To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.
  
  
  METHODS
  Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem. et Schalt followed by pathological, serum biochemical, and coagulation mechanism examination.
  
  
  RESULTS
  The LD50 in mice was 41.12 g/kg; All poisoned mice serum BUN and ALT increased markedly; Thrombocyte decreased and coagulation time increased; The organ index of liver, spleen and kidneys increased significantly; The cells of liver, kidney and heart were degeneration and necrosis, There were extensive hyperemia and hemorrhage in many organs.
  
  
  CONCLUSIONS
  The experiment suggests that the target organs were liver, kidney, heart and blood vessels; The toxic mechanism was the damage on the mitochondrional, endoplasmic reticulum and coagulation system.
authors.affiliation: Department of Forensic Pathology,Wannan Medical College, Wuhu 241001,China.
authors.forename: Wu
authors.initials: W
authors.lastname: Zhang
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Zhu
authors.forename: Li-bao
authors.initials: LB
authors.lastname: Cheng
authors.forename: Yong-hong
authors.initials: YH
authors.lastname: Li
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005260:Female; D049429:Forensic Pathology; D007668:Kidney / Q000473:pathology*; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology*; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D008929:Mitochondria, Heart / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D009206:Myocardium / Q000473:pathology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D011897:Random Allocation
chemical_list: D015415:Biomarkers; D010936:Plant Extracts