title: [Expression and implication of cyclooxygenase-2 mRNA in prostate cancer].
abstract: OBJECTIVE
  To investigate the relationship between cyclooxygenase-2 (COX-2) mRNA expression and the biological behaviors of prostate carcinoma (PCa).
  
  
  METHODS
  The expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined. Seven normal prostate tissues were served as control.
  
  
  RESULTS
  The expression of COX-2 mRNA in normal tissue of 7 control cases was all negative. There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa. There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.
  
  
  CONCLUSIONS
  COX-2 mRNA play an important role in occurrence and progression of the PCa. COX-2 is a tumor marker which may be the possible prognostic factor of PCa.
authors.affiliation: Department of Urology, the First Hospital of Shanghai Jiaotong University, Shanghai 200080, China. yangmingshandachuan@126.com
authors.forename: Ming-Shan
authors.initials: MS
authors.lastname: Yang
authors.forename: Shu-Jie
authors.initials: SJ
authors.lastname: Xia
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Liu
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Sun
authors.forename: Bang-Min
authors.initials: BM
authors.lastname: Han
authors.forename: Ji-Tao
authors.initials: JT
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Ling
authors.forename: Xiao-Da
authors.initials: XD
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012333:RNA, Messenger; D051546:Cyclooxygenase 2