Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity.
This review summarizes the association of increased susceptibility to mycobacterial disease in patients with genetic defects affecting innate and adaptive immunity. The optimum function of CD4 T-cell and macrophage function is critically important for immunity against mycobacteria. Antibody, complement and neutrophil function is not required for effective anti-mycobacterial immunity.
Doffinger
Rainer
R
Department of Clinical Biochemistry and Immunology, Box 109, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.
Patel
Smita Y
SY
Kumararatne
Dinakantha S
DS
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007371:Interferon-gamma / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009161:Mycobacterium; D009164:Mycobacterium Infections / Q000209:etiology / Q000235:genetics* / Q000276:immunology
D007371:Interferon-gamma