Primary Gougerot-Sjögren syndrome: a dermatological approach.
Gougerot-Sjögren syndrome (GSS) is a chronic heterogeneous non-organ-specific autoimmune disease, encompassing a wide spectrum of clinical manifestations. It is characterized by a lymphocytic infiltration of the exocrine glands, also called epitheliitis, resulting in xerostomia and keratoconjunctivitis sicca. The skin can also be involved; for example, xerosis is a consequence of epitheliitis. Dermatological consequences of polyclonal reactivity are vasculitis and manifestations of B-cell proliferation vary from plasma cell infiltrates to B-cell lymphoma.
Roguedas
A-M
AM
Laboratory of Immunology, Brest University Medical School, 2 avenue Foch, 29609 Brest Cedex, France. anne-marie.roguedas-contios@chu.brest.fr
Youinou
P
P
Lemasson
G
G
Pennec
Y-L
YL
Misery
L
L
D006801:Humans; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology