Short homodimeric and heterodimeric coiled coils.
In this communication, we discuss the design, synthesis, and characterization of four peptides which are able to self-assemble into five different homo- and heterodimeric alpha-helical coiled coils based on the pH of their environment. These peptides are very short, containing only 14 or 21 amino acids each, and illustrate the minimum requirements necessary to form dimeric coiled coils which are critical in a large number of biological and materials design applications.
Dong
He
H
Department of Chemistry and Bioengineering, Rice University, 6100 Main Street, Mail Stop 60, Houston, Texas 77005, USA.
Hartgerink
Jeffrey D
JD
D000595:Amino Acid Sequence; D001672:Biocompatible Materials / Q000737:chemistry; D019281:Dimerization; D006863:Hydrogen-Ion Concentration; D046911:Macromolecular Substances / Q000737:chemistry; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D011489:Protein Denaturation; D017433:Protein Structure, Secondary
D001672:Biocompatible Materials; D046911:Macromolecular Substances; D010455:Peptides