title: The role of neural activity in cortical axon branching.
abstract: Axonal branching is an important process for establishing the final pattern of connections between a neuron and its target cells. Cortical connections between upper-layer cells in the neocortex have provided insights into the cellular mechanisms by which electrical activity regulates neural connectivity, including branch formation. Recent evidence further indicates that spontaneous firing and synaptic transmission contribute to axonal branching of cortical neurons through postsynaptic activation.
authors.affiliation: Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Uesaka
authors.forename: Edward S
authors.initials: ES
authors.lastname: Ruthazer
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yamamoto
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D002454:Cell Differentiation / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D006801:Humans; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D009924:Organ Culture Techniques; D017470:Receptors, Glutamate / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D017470:Receptors, Glutamate