title: Crystallization and preliminary crystallographic studies of an antitumour lectin from the edible mushroom Agrocybe aegerita.
abstract: An antitumour lectin named AAL has been purified from the fruiting body of edible mushroom Agrocybe aegerita. In addition to having a distinct bioactivity, AAL shows strong inhibition effects on human and mouse tumour cells. It has been shown that AAL exerts its antitumour effects via apoptosis-induction. AAL and AAL-lactose complex have been crystallized and their diffraction data were collected with resolution of 2.6 A and 3.0 A, respectively. Both crystals belong to space group P 6122 with unit cell parameters a = 123.98 A, b = 123.98 A, c = 56.86 A, alpha= beta=90 degrees, gamma = 120 degrees and a = 123.69 A, b = 123.69 A, c = 56.64 A, alpha = beta = 90 degrees, gamma = 120 degrees, respectively.
authors.affiliation: Center for Structural and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liang
authors.forename: Ye
authors.initials: Y
authors.lastname: Xiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.forename: Da-Cheng
authors.initials: DC
authors.lastname: Wang
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D005502:Food; D037102:Lectins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D037102:Lectins