title: Recognition characters in peptide-polyphenol complex formation.
abstract: Dietary polyphenols have received attention for their anti-oxidative, anti-carcinogenic and anti-neurodegenerative effects. Polyphenols bind to proteins leading to the formation of soluble or insoluble protein-polyphenol complexes which could significantly influence their biological activities. NMR and molecular modeling studies were performed to investigate the influence of the bulk, flexibility and hydrophobicity of polyphenols on the association with bradykinin, the peptide model. Our results show that the strength of the interactions could be positively correlated with polyphenol hydrophobicity and a comparison between pentagalloylglucose and vescalagin indicated that flexibility might play a positive role in the interaction with peptides and proteins.
authors.affiliation: Laboratoire de physique et biophysique, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
authors.forename: T
authors.initials: T
authors.lastname: Richard
authors.forename: D
authors.initials: D
authors.lastname: Lefeuvre
authors.forename: A
authors.initials: A
authors.lastname: Descendit
authors.forename: S
authors.initials: S
authors.lastname: Quideau
authors.forename: J P
authors.initials: JP
authors.lastname: Monti
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D001920:Bradykinin / Q000737:chemistry* / Q000378:metabolism*; D002396:Catechols / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism*; D047348:Hydrolyzable Tannins / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism*; D018583:Pliability; D059808:Polyphenols; D011487:Protein Conformation; D011522:Protons
chemical_list: D001713:Biphenyl Compounds; D002396:Catechols; D005419:Flavonoids; D047348:Hydrolyzable Tannins; D010636:Phenols; D059808:Polyphenols; D011522:Protons; C084709:vescalagin; C435084:pentagalloylglucose; D001920:Bradykinin