Understanding omega-3's.
Omega-3 fatty acids are a subset of polyunsaturated fatty acids found in marine sources as eicosapentaenoic acid and docosahexaenoic acid and in some leafy vegetables, nuts, and oils as alpha-linolenic acid (ALA). The metabolism of omega-3's may explain the cardioprotective effects observed in epidemiologic and experimental studies. Although most data for cardioprotective effects come from studies of marine sources, vegetable sources of omega-3 fatty acids (alpha-linolenic acid) may have similar effects through in vivo conversion to eicosapentaenoic acid and docosahexaenoic acid. This document will provide an overview of omega-3 fatty acids with a focus on specific sources, metabolism, safety issues, and their potential indication for cardiovascular prevention.
DeFilippis
Andrew P
AP
Division of General Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA. APDeF@yahoo.com
Sperling
Laurence S
LS
D000818:Animals; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D004032:Diet; D038441:Diet, Mediterranean; D015118:Eicosapentaenoic Acid / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000502:physiology*; D005395:Fish Oils; D005399:Fishes; D005502:Food; D005519:Food Preservation; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D017962:alpha-Linolenic Acid
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D017962:alpha-Linolenic Acid; D015118:Eicosapentaenoic Acid