Accumulation of celecoxib with a 7-fold higher drug exposure in individuals homozygous for CYP2C9*3.
Lundblad
Mia Sandberg
MS
Ohlsson
Staffan
S
Johansson
Peter
P
Lafolie
Pierre
P
Eliasson
Erik
E
D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000493:pharmacokinetics*; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000493:pharmacokinetics*
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; D000068579:Celecoxib