A high-yielding preparation of beta-ketonitriles.
[reaction: see text] beta-Ketonitriles are important precursors for a wide variety of biologically active heterocycles. A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide beta-ketonitriles is reported. The procedure is successful with enolizable and nonenolizable esters as well as hindered nitrile anions.
Ji
Yaohui
Y
Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912, USA.
Trenkle
William C
WC
Vowles
James V
JV