Feeding artery of laryngeal and hypopharyngeal cancers: role of the superior thyroid artery in superselective intraarterial chemotherapy.
The purpose of this study was to elucidate the role of the superior thyroid artery in intra-arterial infusion chemotherapy for laryngeal and hypopharyngeal cancers. Thirty-nine patients with laryngeal cancer and 29 patients with hypopharyngeal cancer underwent intra-arterial infusion chemotherapy. We performed a retrospective analysis of the feeding arteries confirmed by computed tomography during selective arteriography and compared the results with the extent of the tumors. In 14 of 39 laryngeal and 15 of 29 hypopharyngeal cancers, the tumor did not cross the midline (group 1). In the remaining 25 and 14 cancers, respectively, the tumor crossed the midline or located in the center (group 2). For 13 of 14 laryngeal and 7 of 15 hypopharyngeal cancers in group 1 and for 6 of 25 laryngeal cancers in group 2, the entire tumor was contrast enhanced by the ipsilateral superior thyroid and/or superior laryngeal artery. For 12 of 25 laryngeal and 1 of 14 hypopharyngeal cancers in group 2, the entire tumor was contrast enhanced by the bilateral superior thyroid artery. For the other patients, infusion via the other arterial branches such as the inferior thyroid and the lingual arteries were needed to achieve contrast enhancement of the entire tumor. Superselective intra-arterial chemotherapy for laryngeal cancer from the superior thyroid artery is appropriate, whereas that for hypopharyngeal cancer is less sufficient. To accomplish contrast enhancement of the entire tumor, additional intra-arterial infusion from other arteries such as the inferior thyroid artery is often necessary.
Terayama
Noboru
N
Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, 920-8641, Japan. tera@rad.m.kanazawa-u.ac.jp
Sanada
Junichiro
J
Matsui
Osamu
O
Kobayashi
Satoshi
S
Kawashima
Hiroko
H
Yamashiro
Masashi
M
Takanaka
Tsuyoshi
T
Kumano
Tomoyasu
T
Yoshizaki
Tomokazu
T
Furukawa
Mitsuru
M
D000368:Aged; D000792:Angiography; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001158:Arteries / Q000033:anatomy & histology*; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy; D007261:Infusions, Intra-Arterial / Q000379:methods*; D007822:Laryngeal Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000098:blood supply; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents