[Effect of fosinopril on some parameters of endothelial function in patients with metabolic syndrome].
Angiotensin converting enzyme inhibitor fosinopril was given for 12 weeks to 92 patients with hypertension and metabolic syndrome. Spectra of carbohydrates and lipids, blood plasma kallikrein-kinin and prostacyclin-thromboxane systems, vascular endothelium dependent vasodilating function were studied in all patients. Hypertension was accompanied with lowering of endothelium dependent vasodilation which degree correlated with lowering of prostacyclin and elevation of thromboxane levels, dys-balance of kallikrein-kinin system as well as with severity of hypertension and metabolic syndrome. Effective blood pressure lowering caused by therapy with fosinopril was associated with stabilization of parameters of kallikrein-kinin and prostacyclin-thromboxane systems, improvement of endothelium dependent vasodilation.
Gil'mutdinova
L T
LT
Syrtlanova
E R
ER
Sharapova
S P
SP
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D017328:Fosinopril / Q000494:pharmacology*; D006801:Humans; D016234:Kallikrein-Kinin System / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology*; D008875:Middle Aged; D044062:Prostaglandins I / Q000097:blood; D012720:Severity of Illness Index; D013931:Thromboxanes / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
D000959:Antihypertensive Agents; D044062:Prostaglandins I; D013931:Thromboxanes; D017328:Fosinopril