High-sensitivity C-reactive protein and parameters of left ventricular dysfunction.
BACKGROUND
Elevated levels of high-sensitivity C-reactive protein (CRP), an inflammatory marker, have been associated with heart failure. However, it is not known which parameters of left ventricular dysfunction correlate with elevated levels of CRP.


RESULTS
In this cross-sectional study of 98 patients referred for cardiac catheterization, we investigated whether commonly used clinical indices of left ventricular dysfunction correlated with CRP levels. CRP levels were elevated to a greater degree in participants with diabetes mellitus (P =.006) and heart failure (P =.003). Increased CRP levels were associated with increased plasma levels of B-type natriuretic peptide (BNP; P =.0001), decreased left ventricular ejection fraction (LVEF; P =.02), and increased left-ventricular end-diastolic pressure (LVEDP; P =.0005). After multivariable adjustment, LVEDP and CRP were independently associated (P =.046).


CONCLUSIONS
CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP.
Shah
Sanjiv J
SJ
Division of Cardiology, Department of Medicine, University of California, San Francisco, 94143, USA.
Marcus
Gregory M
GM
Gerber
Ivor L
IL
McKeown
Barry H
BH
Vessey
Joshua C
JC
Jordan
Mark V
MV
Huddleston
Michele
M
Foster
Elyse
E
Chatterjee
Kanu
K
Michaels
Andrew D
AD
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003971:Diastole; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011446:Prospective Studies; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000503:physiopathology*; D017725:Ventricular Pressure
D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein