Cause of death: suicide.
In the last decade, apoptosis has gained recognition as an important event determining the structure and function of the myocardium. The purpose of this review is to provide insights into the mechanisms controlling programmed cell death of myocytes. In this regard, the role of the local renin-angiotensin system and oxidative stress is emphasized. Moreover, the effect of cell death on ventricular remodeling and performance is analyzed. The impact of the identification of apoptosis in the heart on the current view of myocardium as a dynamic organ is discussed.
Kajstura
Jan
J
Cardiovascular Research Institute, Department of Medicine, New York Medical College, Vosburgh Pavilion, Room 302, Valhalla, New York 10595, USA. jan-kajstura@nymc.edu
Bolli
Roberto
R
Sonnenblick
Edmund H
EH
Anversa
Piero
P
Leri
Annarosa
A
D000818:Animals; D017209:Apoptosis; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D012084:Renin-Angiotensin System; D020257:Ventricular Remodeling