Marked decrease of plasma VEGF after implantation of autologous bone marrow mononuclear cells in a patient with critical limb ischemia--a case report.
The authors performed autologous bone marrow mononuclear cells implantation (BMI) in a 79-year-old man with critical limb ischemia. After BMI, the resting pain of the ischemic leg improved gradually. They measured the plasma concentrations of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and serum hepatocyte growth factor (HGF) in the blood from bilateral femoral veins. Before BMI, the plasma VEGF and bFGF concentrations were much greater in the ischemic leg than in the other lower limb, but decreased to the same concentrations as those in the contralateral lower extremity after BMI. The large concentrations of the angiogenic factors VEGF and bFGF in plasma indicate the severity and extent of the leg ischemia. BMI resulted in lower levels of VEGF and bFGF, and this fall is the hallmark of the effectiveness of BMI in the treatment of peripheral artery disease.
Ozawa
Takuya
T
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan. takuya-o@med.niigata-u.ac.jp
Kato
Kiminori
K
Sanada
Hirofumi
H
Makiyama
Yashiro
Y
Saigawa
Takashi
T
Souda
Satoru
S
Hashimoto
Shigeo
S
Furukawa
Tatsuo
T
Toba
Ken
K
Kodama
Makoto
M
Fujiwara
Hiroshi
H
Namura
Osamu
O
Hayashi
Junichi
J
Yoshimura
Nobuhiko
N
Aizawa
Yoshifusa
Y
D000368:Aged; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay; D005263:Femoral Artery / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008297:Male; D009000:Monocytes / Q000637:transplantation*; D011859:Radiography; D014182:Transplantation, Autologous; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A