title: The relationship of optic disk cupping to retinal vein occlusion: the Beaver Dam Eye Study.
abstract: OBJECTIVE
  To examine the association between optic disk cupping and retinal vein occlusion (RVO).
  
  
  METHODS
  Prospective epidemiologic study.
  
  
  METHODS
  setting: Population-based prospective study in Beaver Dam, Wisconsin. study population: Adults aged 43 to 86 years at baseline (n = 4926). observation procedures: Optic disk cupping and RVO were determined from retinal photographs. A standardized medical examination and questionnaire were administered. main outcome measure: Ten-year cumulative incidence of RVO.
  
  
  RESULTS
  There were 58 persons who developed incident RVO at 5 (n = 31) or 10 (n = 27) years after the baseline examination. Those sustaining RVO were older, had higher intraocular pressure (IOP), and were more likely to have definite or probable glaucoma at the baseline examination. The odds of having an incident RVO increased with increasing cup-to-disk ratio at baseline (odds ratio [OR] = 1.29/0.1 increase in cup-to-disk ratio, 95% confidence interval 1.07, 1.56), while controlling for age, systolic blood pressure, current smoking, diabetes status, and IOP. A similar OR was found after excluding those with glaucoma. Excluding persons with central (as opposed to branch) vein occlusion did not have a significant effect on the OR.
  
  
  CONCLUSIONS
  Cup-to-disk ratio is a significant predictor of risk of incident RVO.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, Madison, WI 53726, USA. kleinb@epi.ophth.wisc.edu
authors.forename: Barbara E K
authors.initials: BE
authors.lastname: Klein
authors.forename: Stacy M
authors.initials: SM
authors.lastname: Meuer
authors.forename: Michael D
authors.initials: MD
authors.lastname: Knudtson
authors.forename: Ronald
authors.initials: R
authors.lastname: Klein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D016021:Epidemiologic Studies; D005260:Female; D005901:Glaucoma / Q000150:complications*; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000150:complications*; D010781:Photography; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D014922:Wisconsin / Q000453:epidemiology