Organ mapping using parelectric spectroscopy.
Whenever physical methods are used in the field of diagnostics, it is necessary to find an unambiguous mapping of the properties of the tested tissues (e.g. normal or pathologic) to their answer to the respective analysis tool such as nuclear magnetic resonance (NMR), ultrasound, x-rays or the relatively new method of parelectric spectroscopy (PS). The well-established non-invasive NMR method has, by now, a sufficiently wide-spread atlas of such mappings. This has to be contrasted to the situation of the PS method where first experiments showed the fulfillment of conditions necessary for any reliable diagnosis, namely the uncertainties of the results being small compared to the differences between the normal and pathologic state of the tissues under test. To help close this gap, we present here results of the behaviour of 12 different organs of mice, taken 20 min after excision and give the dependence of the two most essential PS parameters, the dipole density Delta epsilon and the mobility f(0), on the type of healthy organs. To be able to use tumorous tissues preserved in formaldehyde after excision for comparison purposes, we have been measuring the changes of some organs between the fresh state and the preserved state under formaldehyde for over 180 min each.
Blaschke
T
T
Department of Physics, Freie Universität Berlin, Berlin, Germany.
Sivaramakrishnan
R
R
Gross
M
M
Kramer
K D
KD
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D005557:Formaldehyde / Q000737:chemistry; D005583:Fourier Analysis; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051379:Mice; D015233:Models, Statistical; D011827:Radiation; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013057:Spectrum Analysis / Q000379:methods*; D013997:Time Factors; D014018:Tissue Distribution
D003287:Contrast Media; D005557:Formaldehyde