title: Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis.
abstract: We randomly assigned 17 patients with scaphoid non-union at the proximal pole to three treatment groups: (1) autologous iliac graft (n=6), (2) autologous iliac graft + osteogenic protein-1 (OP-1; n=6), and (3) allogenic iliac graft + OP-1 (n=5). Radiographic, scintigraphic, and clinical assessments were performed throughout the follow-up period of 24 months. OP-1 improved the performance of both autologous and allogenic bone implants and reduced radiographic healing time to 4 weeks compared with 9 weeks in group 1. Helical CT scans and scintigraphy showed that in OP-1-treated patients sclerotic bone was replaced by well-vascularised bone. The addition of OP-1 to allogenic bone implant equalised the clinical outcome with the autologous graft procedure. Consequently the harvesting of autologous graft can be avoided.
authors.affiliation: Department of Orthopedic Surgery, School of Medicine, University of Zagreb, Salata 11, 10000, Zagreb, Croatia.
authors.forename: R
authors.initials: R
authors.lastname: Bilic
authors.forename: P
authors.initials: P
authors.lastname: Simic
authors.forename: M
authors.initials: M
authors.lastname: Jelic
authors.forename: R
authors.initials: R
authors.lastname: Stern-Padovan
authors.forename: D
authors.initials: D
authors.lastname: Dodig
authors.forename: H Pompe
authors.initials: HP
authors.lastname: van Meerdervoort
authors.forename: S
authors.initials: S
authors.lastname: Martinovic
authors.forename: D
authors.initials: D
authors.lastname: Ivankovic
authors.forename: M
authors.initials: M
authors.lastname: Pecina
authors.forename: S
authors.initials: S
authors.lastname: Vukicevic
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D008297:Male; D011877:Radionuclide Imaging; D021361:Scaphoid Bone / Q000000981:diagnostic imaging / Q000293:injuries* / Q000601:surgery*; D036542:Tomography, Spiral Computed; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
chemical_list: C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta