Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles.
Synthesis of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles by the condensation of o-phenylenediamine with 6-fluoro-3,4-dihydro-2H-chroman-2-carboxylic acid, and subsequent reactions with different types of electrophiles, have been reported. Some compounds exhibited promising anti-bacterial activity against Salmonella typhimurium; however, they showed poor activity against S. aureus. The biological activity against PDE IV for potential anti-asthamatic effect, and against DP-IV and PTP 1B for potential anti-diabetic effects was disappointing.
Kumar
Bobba Venkata Siva
BV
Glenmark Research Center, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C. Mahape Navi Mumbai 400 709, India.
Vaidya
Sanjay Dashrath
SD
Kumar
Ramanatham Vinod
RV
Bhirud
Shekar Bhaskar
SB
Mane
Ramchandra Bhimrao
RB
D000215:Acylation; D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002839:Chromans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012486:Salmonella typhimurium / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D002839:Chromans