Predicted and measured disorder in peripherin/rds, a retinal tetraspanin.
Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this protein's C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short C-termini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.
Ritter
L M
LM
Eye Research Institute, Oakland University, Rochester, MI 48309, USA.
Arakawa
T
T
Goldberg
A F X
AF
D000595:Amino Acid Sequence; D002942:Circular Dichroism; D015870:Gene Expression / Q000235:genetics; D057927:Hydrophobic and Hydrophilic Interactions; D007381:Intermediate Filament Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D064531:Peripherins; D018583:Pliability; D011489:Protein Denaturation; D012160:Retina / Q000737:chemistry*; D012995:Solubility; D014461:Ultracentrifugation
D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D064531:Peripherins