title: Three-dimensional line-field Fourier domain optical coherence tomography for in vivo dermatological investigation.
abstract: We demonstrate 3-D optical coherence tomography using only 1-D mechanical scanning. This system uses the principle of Fourier domain optical coherence tomography for depth resolution, 1-D imaging for lateral vertical resolution, and mechanical scanning by a galvanometer for lateral horizontal resolution. An in vivo human fingerpad is investigated in three dimensions with an image size of 480 points (vertical) x 300 points (horizontal) x 1024 points (depth), which corresponds to 2.1 x 1.4 x 1.3 mm. The acquisition time for a single cross section is 1 ms and that for a single volume is 10 s. The system sensitivity is 75.6 dB at a probe beam power of 1.1 mW.
authors.affiliation: University of Tsukuba, Institute of Applied Physics, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan. yasuno@optlab2.bk.tsukuba.ac.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
authors.forename: Takashi
authors.initials: T
authors.lastname: Endo
authors.forename: Shuichi
authors.initials: S
authors.lastname: Makita
authors.forename: Gouki
authors.initials: G
authors.lastname: Aoki
authors.forename: Masahide
authors.initials: M
authors.lastname: Itoh
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Yatagai
mesh_terms: D046169:Dermoscopy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005385:Fingers / Q000033:anatomy & histology*; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods