title: Dietary supplements of vitamins E and C and beta-carotene reduce oxidative stress in cats with renal insufficiency.
abstract: Oxidative stress may contribute to the progression of chronic renal failure. In this study, cats with spontaneous renal insufficiency were fed a dry cat food supplemented with the antioxidants vitamins E and C, and beta-carotene for 4 weeks. When compared with healthy cats, cats with renal insufficiency had a tendency to oxidative stress. The antioxidant supplements significantly reduced DNA damage in cats with renal insufficiency as evidenced by reduced serum 8-OHdG and comet assay parameters. Therefore, supplements of vitamins E and C and beta-carotene as antioxidants may be beneficial to cats with renal disease.
authors.affiliation: Hill's Science and Technology Center, 1035 NE 43rd Street, Topeka, KS 66617, USA. Shiguang_yu@hillspet.com
authors.forename: S
authors.initials: S
authors.lastname: Yu
authors.forename: I
authors.initials: I
authors.lastname: Paetau-Robinson
mesh_terms: D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use*; D015415:Biomarkers; D001806:Blood Urea Nitrogen; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003404:Creatinine / Q000097:blood; D018592:Cross-Over Studies; D019587:Dietary Supplements; D005260:Female; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010758:Phosphorus / Q000097:blood; D014810:Vitamin E / Q000627:therapeutic use*; D019207:beta Carotene / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D019207:beta Carotene; D014810:Vitamin E; D010758:Phosphorus; D003404:Creatinine; D001205:Ascorbic Acid