The role of interstitial brachytherapy in the treatment of vaginal and vulvar malignancies.
BACKGROUND
Irradiation has established itself as a treatment for vulvar and vaginal malignancies. Due to the sensitive nature of the vulvar and vaginal tissues, interstitial brachytherapy (iBT) provides an effective, gentle and individualized therapy.


METHODS
Patients with vulvar (nine of 22) and vaginal (13 of 22) malignancies were treated using interstitial pulsed-dose-rate brachytherapy (PDR-iBT). Twelve out of 22 patients were additionally treated using external-beam therapy to the pelvis and regional lymph nodes. The median total dose of PDR-iBT administered to patients with vulvar carcinoma was 55.0 Gy. The median total PDR dose administered to patients with vaginal malignancies amounted to 20.25 Gy.


RESULTS
The median follow-up time for patients with vulvar cancer was 19 months and for patients with vaginal malignancies 27 months. Acute mucositis or skin reactions during iBT were observed in 15 of 22 patients. Two of 22 patients showed delayed side effects. After 6 months, 77.8% of the patients with vulvar cancer (seven out of nine) and 100% of the patients with vaginal malignancies (13 out of 13) achieved complete local remission. One patient out of nine with vulvar carcinoma developed local recurrence, four out of nine regional recurrence, and two out of nine developed regional recurrence and had local tumor following therapy. In patients with malignancies of the vagina, no cases of local recurrence were observed, but distant metastases were found in five out of 13 patients. At the time of analysis, eleven out of 22 patients with vulvar or vaginal carcinoma were still alive.


CONCLUSIONS
IBT achieved good local control without serious delayed side effects in both localizations. However, survival is limited by regional or distant metastases.
Seeger
Annedore R
AR
Department of Radiation Oncology, University of Erlangen-Nuremberg, Erlangen, Germany. annedore.seeger@strahlen.imed.uni-erlangen.de
Windschall
Andrea
A
Lotter
Michael
M
Mehlhorn
Grit
G
Beckmann
Matthias W
MW
Sauer
Rolf
R
Strnad
Vratislav
V
D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012008:Recurrence; D012189:Retrospective Studies; D014625:Vaginal Neoplasms / Q000145:classification / Q000473:pathology / Q000532:radiotherapy*; D014846:Vulvar Neoplasms / Q000145:classification / Q000473:pathology / Q000532:radiotherapy*