Fibroblast growth factor 23: the making of a hormone.
Fibroblast growth factor 23 (FGF23) modulates serum phosphate and 1alpha,25-dihydroxyvitamin D3 levels. FGF23 expression is in turn regulated by 1alpha,25-dihydroxyvitamin D3 and dietary phosphate load, and is strikingly elevated during renal progression. In this issue, Nagano and colleagues report that FGF23 can be modulated by intermittently high dietary phosphate in the presence of compromised renal function.
Schiavi
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Endocrine and Renal Sciences, Genzyme Corporation, Framingham, Massachusetts, USA. susan.schiavi@genzyme.com
D000818:Animals; D002117:Calcitriol / Q000097:blood* / Q000502:physiology; D002118:Calcium / Q000097:blood; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood* / Q000235:genetics; D005786:Gene Expression Regulation; D006706:Homeostasis; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008954:Models, Biological; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000008:administration & dosage / Q000097:blood*; D016226:Phosphorus, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000209:etiology / Q000503:physiopathology
D010281:Parathyroid Hormone; D010710:Phosphates; D016226:Phosphorus, Dietary; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002117:Calcitriol; D002118:Calcium