[Antiherpetic activity of 5-alkynyl derivatives of 2'-deoxyuridine].
A series of new 5-alkynyl-2'-deoxyuridines have been synthesized and their antiherpetic activity was tested in the cultured Vero cells on a model of herpes simplex virus type 1, including its acyclovir-resistant strains. Some test compounds were found to have a significant specific antiherpetic activity. Nucleoside XIV showed the greatest activity. Compounds IV and X also has displayed a significant activity against the herpes simplex virus type 1 strain that is highly resistant to acyclovir. Examining the combined action of substance II with acyclovir and ganciclovir has revealed a synergetic effect.
Andronova
V L
VL
Pchelintseva
A A
AA
Ustinov
A V
AV
Petrunina
A L
AL
Korshun
V A
VA
Skorobogatyĭ
M V
MV
Galegov
G A
GA
D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D024882:Drug Resistance, Viral; D015774:Ganciclovir / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014529:Uridine / Q000031:analogs & derivatives / Q000737:chemistry / Q000502:physiology; D014709:Vero Cells
D000998:Antiviral Agents; D015774:Ganciclovir; D014529:Uridine; D000212:Acyclovir