Neuregulin-1 and myelination.
The trigger for the process of myelin formation during neural development has long been a mystery. Recent studies suggest that this trigger is the growth factor neuregulin-1, expressed on the surface of axons, which signals through ErbB2 and ErbB3 receptors expressed on the surface of myelin-forming glia.
Lemke
Greg
G
The Salk Institute, La Jolla, CA 92037, USA. lemke@salk.edu
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D005727:Ganglia, Spinal / Q000166:cytology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009046:Motor Neurons / Q000166:cytology; D009186:Myelin Sheath / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D020890:Neuregulin-1; D020033:Protein Isoforms / Q000502:physiology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D020893:Receptor, ErbB-3 / Q000502:physiology; D012583:Schwann Cells / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; D020033:Protein Isoforms; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; C490581:Nrg1 protein, mouse