Calcium and NeuroD2 control the development of thalamocortical communication.
Donald Hebb postulated the existence of a mechanism of activity-dependent transcription and synaptic modification almost 60 years ago. While the details of this process are still unclear, a new study by Ince-Dunn et al. in this issue of Neuron indicates that NeuroD2, a calcium-regulated transcription factor, plays a central role in thalamocortical synaptic maturation.
Molnár
Zoltán
Z
Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, Oxford, OX1 3QX, United Kingdom.
Molnár
Elek
E
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009434:Neural Pathways / Q000254:growth & development*; D009479:Neuropeptides / Q000502:physiology*; D013003:Somatosensory Cortex / Q000254:growth & development*; D013788:Thalamus / Q000254:growth & development*
D051792:Basic Helix-Loop-Helix Proteins; D002118:Calcium; D009479:Neuropeptides; C098995:Neurod2 protein, mouse