title: [Cormobidity of sensorineural hearing loss and other autoimmune diseases. Usefulness of laboratory tests].
abstract: OBJECTIVE
  To value if the sensorineural hearing loss (SHL) in several autoimmune diseases (AD) is also secondary to immunomediation.
  
  
  METHODS
  In 342 cases with SHL and any AD and 301 normoacoustic controls with AD a non-specific immunologic battery of tests and a Western-blot (WB) for anticochlear autoantibodies were developed, and cases with SHL were treated with deflazacort.
  
  
  RESULTS
  Alterations in non-specific battery were similar between cases and controls. But a 12,5% of cases with SHL and a 1,6% of normoacoustic showed a positive WB (p<0,001). Steroid therapy improved hearing in 14,3% of cases. In them, sensitivity and specificity of non-specific battery were 78,4% and 75,5%, respectively, to predict response to therapy. These were 98,9% and 81,6% for WB.
  
  
  CONCLUSIONS
  The SHL in cases with AD can be considered immunomediated in a discrete average, but the diagnostic efficiency of WB to predict an improvement after steroid therapy is high.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Clínico Universitario de Valencia. jgarciacall@hotmail.com
authors.forename: F J
authors.initials: FJ
authors.lastname: García Callejo
authors.forename: J
authors.initials: J
authors.lastname: Corts
authors.forename: C
authors.initials: C
authors.lastname: de Paula Vernetta
authors.forename: P
authors.initials: P
authors.lastname: Laporta
authors.forename: J
authors.initials: J
authors.lastname: Ramírez Sabio
authors.forename: J
authors.initials: J
authors.lastname: Marco Algarra
mesh_terms: D000328:Adult; D000906:Antibodies / Q000276:immunology; D001301:Audiometry, Pure-Tone / Q000379:methods; D001327:Autoimmune Diseases / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D015153:Blotting, Western; D019411:Clinical Laboratory Techniques; D003051:Cochlea / Q000276:immunology; D015897:Comorbidity; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male
chemical_list: D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M