title: Complete unilateral ureteral obstruction in the fetal lamb. Part I: long-term outcomes of renal hemodynamics and anatomy.
abstract: OBJECTIVE
  We evaluated the long-term consequences of complete fetal UUO on renal hemodynamics and anatomy.
  
  
  METHODS
  A total of 26 fetal lambs underwent surgical UUO at 90 days of gestation and 14 twin matched animals served as controls. Synchronous bilateral ARBF was measured using mean transit time technology. Standard anatomical analysis, including evaluation of RPV, was performed in the kidneys. Measurements were done 10, 20 and 40 days following UUO in groups 1 to 3, respectively and in 1-month-old lambs in group 4.
  
  
  RESULTS
  All obstructed kidneys underwent typical hydronephrotic transformations with a progressive decrease in parenchymal volume compared to that of contralateral and control kidneys. ARBF in obstructed kidneys was significantly decreased compared to their contralateral counterparts in all groups (p <0.01). Comparing ARBF to RPV showed that the decrease in ARBF was proportional to the loss of parenchymal volume in fetal obstructed kidneys but it remained significant in lambs (p <0.05).
  
  
  CONCLUSIONS
  Complete UUO alters ARBF, while vascularization of the remaining renal parenchyma is maintained in fetuses. Profound impairment of the renal arterial supply observed in lambs may be due to physiological changes linked to birth.
authors.affiliation: Department of Pediatric Surgery, Claude Bernard University, Lyon, France. pierre-yves.mure@chu-lyon.fr
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Mure
authors.forename: Thomas
authors.initials: T
authors.lastname: Gelas
authors.forename: Mehdi
authors.initials: M
authors.lastname: Benchaib
authors.forename: Frédérique
authors.initials: F
authors.lastname: Dijoud
authors.forename: Axel
authors.initials: A
authors.lastname: Feyaerts
authors.forename: Thierry
authors.initials: T
authors.lastname: Roger
authors.forename: Pierre
authors.initials: P
authors.lastname: Mouriquand
mesh_terms: D000818:Animals; D006439:Hemodynamics; D007668:Kidney / Q000196:embryology / Q000473:pathology*; D007674:Kidney Diseases / Q000196:embryology / Q000209:etiology*; D009929:Organ Size; D012756:Sheep; D013997:Time Factors; D014517:Ureteral Obstruction / Q000150:complications* / Q000196:embryology / Q000503:physiopathology*