title: Prevention of erosion and abrasion by a high fluoride concentration gel applied at high frequencies.
abstract: The aim of this study was to determine maximum attainable protection of enamel from erosion and erosion abrasion using a highly fluoridated gel with and without additional fluoride from toothpaste. Thirty-six bovine enamel specimens were subjected to six erosive attacks per day (1% citric acid with pH 2.3 for 30 s), while the rest of the day the specimens were in artificial saliva. There were four treatment groups (9 specimens in each group): fluoride-free toothpaste/saliva slurry twice daily (group T0), fluoride-containing toothpaste/saliva slurry twice daily using 1,250 ppm F toothpaste (group TF), fluoride-containing toothpaste/saliva slurry twice per day plus application of a highly fluoridated gel (12,500 ppm F) twice a day for 120 s (group 2F) and a group with gel application 8 times a day (group 8F). Additionally, half of each specimen in all groups was subjected to brushing abrasion during application of the toothpaste/saliva slurry. Brushing abrasion alone led to no observable enamel loss measured with profilometry. After 14 days of cycling of erosion without toothbrushing abrasion, high-fluoride gel application 2 or 8 times daily showed significantly less enamel loss (median 24/19 microm) than with toothpaste with or without fluoride (41/45 microm). After 14 days of cycling of erosion and toothbrushing abrasion, gel application 2 or 8 times daily (33/29 microm) showed significantly less enamel loss than toothpaste with or without fluoride (57/62 microm). We conclude that a highly fluoridated acidic gel is able to protect enamel from erosion and toothbrushing abrasion while fluoridated tooth paste provides little protection.
authors.affiliation: Department of Cariology Endodontology Pedodontology, ACTA, Amsterdam, The Netherlands. m.lagerweij@acta.nl
authors.forename: M D
authors.initials: MD
authors.lastname: Lagerweij
authors.forename: W
authors.initials: W
authors.lastname: Buchalla
authors.forename: S
authors.initials: S
authors.lastname: Kohnke
authors.forename: K
authors.initials: K
authors.lastname: Becker
authors.forename: A M
authors.initials: AM
authors.lastname: Lennon
authors.forename: T
authors.initials: T
authors.lastname: Attin
mesh_terms: D000588:Amines / Q000008:administration & dosage; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage; D002124:Calcium Fluoride / Q000494:pharmacology; D002417:Cattle; D003743:Dental Enamel / Q000187:drug effects; D003747:Dental Enamel Solubility / Q000187:drug effects*; D003802:Dentifrices / Q000008:administration & dosage; D003959:Diamines; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000008:administration & dosage; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D018709:Statistics, Nonparametric; D014072:Tooth Abrasion / Q000517:prevention & control*; D017001:Tooth Demineralization / Q000517:prevention & control; D014077:Tooth Erosion / Q000139:chemically induced / Q000517:prevention & control*; D014089:Tooth Remineralization
chemical_list: D000588:Amines; D003802:Dentifrices; D003959:Diamines; D005460:Fluorides, Topical; C495399:Olaflur; D002124:Calcium Fluoride; D001205:Ascorbic Acid; D005459:Fluorides