title: Artificial viruses: a nanotechnological approach to gene delivery.
abstract: Nanotechnology is a rapidly expanding multidisciplinary field in which highly sophisticated nanoscale devices are constructed from atoms, molecules or (macro)molecular assemblies. In the field of gene medicine, systems for delivering nucleic acids are being developed that incorporate virus-like functions in a single nanoparticle. Although their development is still in its infancy, it is expected that such artificial viruses will have a great impact on the advancements of gene therapeutics.
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands. e.mastrobattista@pharm.uu.nl
authors.forename: Enrico
authors.initials: E
authors.lastname: Mastrobattista
authors.forename: Marieke A E M
authors.initials: MA
authors.lastname: van der Aa
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
authors.forename: Daan J A
authors.initials: DJ
authors.lastname: Crommelin
mesh_terms: D000818:Animals; D004247:DNA / Q000008:administration & dosage / Q000235:genetics; D015316:Genetic Therapy / Q000639:trends*; D005822:Genetic Vectors; D006801:Humans; D036103:Nanotechnology / Q000639:trends*; D019065:Virus Assembly / Q000502:physiology; D014780:Viruses / Q000235:genetics*
chemical_list: D004247:DNA