title: A population-based study of the incidence, management and prognosis of hepatic metastases from colorectal cancer.
abstract: BACKGROUND
  The aim of this population-based study was to evaluate the incidence, management and prognosis of patients with hepatic metastases related to colorectal cancer using data from the Digestive Cancer Registry of Calvados, France.
  
  
  METHODS
  Of 1325 patients with colorectal cancer registered between January 1994 and December 1999, 358 developed hepatic metastases. Logistic regression was used to analyse prognostic factors. Survival analysis was carried out with Cox's proportional hazards model.
  
  
  RESULTS
  Some 18.8 per cent of patients had synchronous metastases, while 29.3 per cent developed metastases at 3 years. Of patients with hepatic metastases, 17.3 per cent had a surgical resection, 40.2 per cent were treated with palliative chemotherapy and 42.5 per cent had symptomatic treatment. Factors associated with receiving symptomatic treatment only were age over 75 years and more than one metastasis, but not place of treatment. Median survival after a diagnosis of hepatic metastases was 10.7 (range 4.6-23.1) months. Significant adverse prognostic factors were: age over 75 years (P = 0.001), lymph node invasion of primary tumour (P = 0.024), bilateral distribution of metastases (P = 0.001), other metastases (P = 0.004) and symptomatic treatment only (P = 0.041).
  
  
  CONCLUSIONS
  Despite improvement in treatment for hepatic metastases, age and extent of disease remain limiting factors for surgical resection and palliative chemotherapy.
authors.affiliation: Digestive Cancer Registry of Calvados, Cancers and Populations, National Institute of Health and Medical Research (ESPRI), Caen, France. julien.leporrier2@libertysurf.fr
authors.forename: J
authors.initials: J
authors.lastname: Leporrier
authors.forename: J
authors.initials: J
authors.lastname: Maurel
authors.forename: L
authors.initials: L
authors.lastname: Chiche
authors.forename: S
authors.initials: S
authors.lastname: Bara
authors.forename: P
authors.initials: P
authors.lastname: Segol
authors.forename: G
authors.initials: G
authors.lastname: Launoy
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms; D004812:Epidemiologic Methods; D005260:Female; D005602:France / Q000453:epidemiology; D006498:Hepatectomy / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents