title: Adult T-cell leukemia presenting with acute liver failure.
abstract: Malignant infiltration of the liver is a rare cause of acute liver failure accounting for less than 1% of cases. We describe a case of adult T-cell leukemia (ATL) that presented with a prodromal illness that progressed to jaundice, hepatic encephalopathy, multisystem failure and death within 8 weeks. Liver histology revealed massive infiltration with atypical lymphocytes typical of ATL and liver necrosis.
authors.affiliation: Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK. nick.powell@nhs.uk
authors.forename: Nicholas
authors.initials: N
authors.lastname: Powell
authors.forename: Ferry
authors.initials: F
authors.lastname: Rusli
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Hubscher
authors.forename: Mamatha
authors.initials: M
authors.lastname: Karanth
authors.forename: David
authors.initials: D
authors.lastname: Mutimer
mesh_terms: D017809:Fatal Outcome; D005260:Female; D015490:HTLV-I Infections / Q000175:diagnosis*; D006529:Hepatomegaly / Q000000981:diagnostic imaging; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000175:diagnosis*; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000150:complications / Q000175:diagnosis* / Q000821:virology; D008875:Middle Aged; D013163:Splenomegaly / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed