[Adrenal androgen and bone metabolism].
Dehydroepiandrosterone-sulfate (DHEA-S), the sulfated form of dehydroepiandrosterone, is the most abundant steroids in human, although its biological activities are seemingly weak. Recently, basic and clinical observations suggest dehydroepiandrosterone (DHEA) increase bone mineral densities in the elderly. Large-scale double-blinded clinical trials are necessary.
Goto
Kiminobu
K
Kasamatsu-kai Medical Corporation Ariyoshi Hospital, Internal Medicine and the Elderly Care.
Yanase
Toshihiko
T
Takayanagi
Ryoichi
R
Nawata
Hajime
H
D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000378:metabolism; D010006:Osteoblasts / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases
D004967:Estrogens; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; C500554:DDSP protein, human; D017027:Protein Tyrosine Phosphatases