title: Prostate cancer detected by uPM3: radical prostatectomy findings.
abstract: uPM3 is the first urine-based genetic test that is highly specific for detecting prostate cancer. The histopathologic characteristics of uPM3-detected cancer in radical prostatectomy specimens have not been previously described. We evaluated a consecutive series of radical prostatectomies to determine the extent, zonal distribution and other features of prostate cancer following uPM3 detection. A total of 24 whole-mounted, totally embedded radical prostatectomy specimens were evaluated. All patients had clinically localized cancer and none received preoperative therapy. Zonal location of cancer, distance to the urethra, cancer volume, Gleason grade and multicentricity were recorded; volume of cancer was measured using the grid-counting method. Patients ranged in age from 43 to 75 years (mean 65 years). In 21/24 cases, cancer involved the transition and peripheral zones and was multicentric (87%). Mean cancer volume was 3.96 cm3 (range 0.08-16.86 cm3). Mean distance to the urethra was 0.50 cm for the closest cancer and 0.61 cm for the most distant cancer. Mean Gleason score was 7 (range 5-9); pathologic stage was pT2 for 17 cases and pT3 for seven cases. The uPM3 is an independent and specific biomarker that detects prostate cancers of similar volume, location, extent and grade as other tests for early detection. uPM3 does not preferentially identify large or aggressive prostate cancers.
authors.affiliation: Bostwick Laboratories, Glen Allen, VA 23060, USA. dbostwick@bostwicklaboratories.com
authors.forename: David G
authors.initials: DG
authors.lastname: Bostwick
authors.forename: Victor E
authors.initials: VE
authors.lastname: Gould
authors.forename: Junqi
authors.initials: J
authors.lastname: Qian
authors.forename: Martin
authors.initials: M
authors.lastname: Susani
authors.forename: Michael
authors.initials: M
authors.lastname: Marberger
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011467:Prostate / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000652:urine; D012333:RNA, Messenger / Q000235:genetics / Q000652:urine; D012334:RNA, Neoplasm / Q000235:genetics / Q000652:urine; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C479341:prostate cancer antigen 3, human