title: Intracystic papilloma in the breast of a male given long-term phenothiazine therapy: a case report.
abstract: We experienced a very rare case of intracystic papilloma in a 57-year-old man who came to our hospital complaining of a left subareolar mass and nipple discharge. The patient had a history of chronic schizophrenia, necessitating long-term treatment with phenothiazines. His serum prolactin levels were elevated. Mammography demonstrated a well defined mass with microcalcifications. Ultrasonography revealed a cyst with an intracystic component. The inner lesion of the mass enhanced on contrast-enhanced computed tomography. The carcinoembryonic antigen concentration of the cyst fluid was 400 ng/mL and no malignant cells were found by aspiration biopsy cytology. Excisional biopsy was performed under local anesthesia. Pathological examination revealed the intracystic component to be intracystic papilloma. There are ten reports of male intracystic papilloma including ours. We report the second case of a patient given long-term phenothiazine therapy, which is known to increase serum prolactin levels.
authors.affiliation: Department of Surgery, Minoh City Hospital, 5-7-1, Kayano, Osaka 562-8562, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Okada
authors.forename: Haruo
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Rio
authors.initials: R
authors.lastname: Handa
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Naoi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Oshima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.forename: Masaki
authors.initials: M
authors.lastname: Tsujie
authors.forename: Shohei
authors.initials: S
authors.lastname: Iijima
authors.forename: Eiji
authors.initials: E
authors.lastname: Kurokawa
authors.forename: Nobuteru
authors.initials: N
authors.lastname: Kikkawa
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kadone
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D047688:Breast Cyst / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D018567:Breast Neoplasms, Male / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008327:Mammography; D008875:Middle Aged; D010212:Papilloma / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D010640:Phenothiazines / Q000009:adverse effects*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D014150:Antipsychotic Agents; D002272:Carcinoembryonic Antigen; D010640:Phenothiazines