title: Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".
authors.affiliation: Institute of Pathology, Case Western Reserve University, OH 44106, USA.
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Lee
authors.forename: Paula I
authors.initials: PI
authors.lastname: Moreira
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Perry
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000544:Alzheimer Disease / Q000235:genetics*; D000818:Animals; D006801:Humans; D015227:Lipid Peroxidation; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D053764:Presenilin-1; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D017382:Reactive Oxygen Species