Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk.
To investigate the association between occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines and diesel and bladder cancer risk and the modification by smoking and metabolic polymorphisms, have we recruited 200 cases and 385 population controls. The adjusted OR of bladder cancer was 5.75 (95%CI 2.09-15.83) comparing the highest tertile of the cumulative probability of occupational exposure to aromatic amines with no occupational exposure. A possible interaction between occupational exposures to aromatic amines and smoking was found. The increased ORs of GSTM1, GSTT1, NAT2 and SULT1A1 among those ever occupational exposed was explored by estimating the false-positive report probability. We confirm that occupational exposure to aromatic amines is associated with an increase in bladder cancer risk.
Kellen
Eliane
E
Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg, Belgium. eliane.kellen@med.kuleuven.ac.be
Zeegers
Maurice
M
Paulussen
Aimée
A
Vlietinck
Robert
R
Vlem
Eddy Van
EV
Veulemans
Hendrik
H
Buntinx
Frank
F
D000368:Aged; D000369:Aged, 80 and over; D000395:Air Pollutants, Occupational / Q000506:poisoning*; D000588:Amines / Q000506:poisoning; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D015239:Arylsulfotransferase / Q000235:genetics; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D016017:Odds Ratio; D011084:Polycyclic Aromatic Hydrocarbons / Q000506:poisoning; D011110:Polymorphism, Genetic; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000235:genetics; D001335:Vehicle Emissions / Q000506:poisoning
D000395:Air Pollutants, Occupational; D000588:Amines; D001191:Arylamine N-Acetyltransferase; D015239:Arylsulfotransferase; D005982:Glutathione Transferase; D011084:Polycyclic Aromatic Hydrocarbons; D001335:Vehicle Emissions; C478900:NAT2 protein, human; C413545:glutathione S-transferase T1; C117544:SULT1A1 protein, human