title: Prevention of painful neuromas by oblique transection of peripheral nerves.
abstract: OBJECTIVE
  Neuroma formation often occurs at the proximal stump of the transected nerve, complicating the healing process after gap injuries or nerve biopsies. Most such neuromas cause therapy-resistant neuropathic pain. The purpose of this study was to determine whether oblique transection of the proximal stump of the sciatic nerve can prevent neuroma formation.
  
  
  METHODS
  The sciatic nerves of 10 rats were transected unilaterally at an angle of 30 degrees, and the peripheral segments of the nerves were removed. In 10 control animals the sciatic nerves were transected at a perpendicular angle. Twenty weeks after surgery the nerves were reexposed and collected. The presence of neuromas was determined by two board certified pathologists on the basis of histopathological evaluations.
  
  
  CONCLUSIONS
  The oblique transection of peripheral nerves, contrary to perpendicularly transected nerves, is rarely followed by classic neuroma development. Moreover, neuropathic pain is significantly reduced compared with that following the traditional method of nerve transection.
authors.affiliation: Department of Physiology, Division of Neurosurgery, Medical University of Silesia, Katowice, Poland. Vie@alpha.net.pl
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Marcol
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kotulska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Larysz-Brysz
authors.forename: Grazyna
authors.initials: G
authors.lastname: Bierzyńska-Macyszyn
authors.forename: Pawel
authors.initials: P
authors.lastname: Wlaszczuk
authors.forename: Joanna
authors.initials: J
authors.lastname: Lewin-Kowalik
mesh_terms: D000818:Animals; D008297:Male; D009463:Neuroma / Q000209:etiology / Q000517:prevention & control*; D019635:Neurosurgical Procedures / Q000379:methods*; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000473:pathology / Q000601:surgery*