title: Choroidal vein and artery occlusion following photodynamic therapy in eyes with pathologic myopia.
abstract: OBJECTIVE
  To describe highly myopic patients in which either the large choroidal veins or arteries were occluded following PDT treatment.
  
  
  METHODS
  Demographic features of two highly myopic patients in which large choroidal vessels were occluded at 1 week following PDT, among a total of 23 patients who received PDT due to choroidal neovascularization (CNV) caused by high myopia, were demonstrated.
  
  
  RESULTS
  In case 1, ICG angiography demonstrated the complete occlusion of several large choroidal veins within the laser-applied area at 1 week after PDT. In case 2, ICG angiography demonstrated an occlusion of choroidal artery emanating from beneath the CNV. One month after PDT, re-perfusion of the occluded choroidal vessels was noted in both patients.
  
  
  CONCLUSIONS
  Occlusion of choroidal veins has never been reported in eyes with CNV treated by verteporfin therapy. Although further studies are necessary, occlusion of large choroidal vessels might happen in highly myopic eyes more commonly than expected. ICG angiography at 1 week after PDT was useful to evaluate the impact of PDT on large choroidal vessels.
authors.affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. k.ohno.oph@tmd.ac.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ohno-Matsui
authors.forename: Muka
authors.initials: M
authors.lastname: Moriyama
authors.forename: Kengo
authors.initials: K
authors.lastname: Hayashi
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002829:Choroid / Q000098:blood supply*; D020256:Choroidal Neovascularization / Q000209:etiology / Q000601:surgery; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000150:complications*; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000009:adverse effects; D011166:Porphyrins / Q000009:adverse effects; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000175:diagnosis; D000077362:Verteporfin
chemical_list: D004396:Coloring Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin; D007208:Indocyanine Green