title: Anti-topoisomerase I antibodies in systemic lupus erythematosus as a marker of severe nephritis.
abstract: The authors report nine patients with systemic lupus erythematosus associated with anti-topoisomerase I antibodies (ELISA test) without features of systemic sclerosis. These antibodies were correlated with the disease activity and might be a marker of the severity of the closely related to difusse proliferative glomerulonephritis.
authors.affiliation: Department of Internal Medicine, University Hospital Hôtel-Dieu, Place Alexis Ricordeau, 44 035, Nantes, France. mohamed.hamidou@chu-nantes.fr
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Hamidou
authors.forename: Marie A
authors.initials: MA
authors.lastname: Audrain
authors.forename: Agathe
authors.initials: A
authors.lastname: Masseau
authors.forename: Christian
authors.initials: C
authors.lastname: Agard
authors.forename: Anne
authors.initials: A
authors.lastname: Moreau
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000276:immunology*; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D004264:DNA Topoisomerases, Type I