Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.
Ahn
Jin Hee
JH
Bio-Organic Science Division, Korea Research Institute of Chemical Technology, 100 Jang-Dong, Yuseong-Gu, Daejeon 305-343, Republic of Korea.
Kim
Seung Jun
SJ
Park
Woul Seong
WS
Cho
Sung Yun
SY
Ha
Jae Du
JD
Kim
Sung Soo
SS
Kang
Seung Kyu
SK
Jeong
Dae Gwin
DG
Jung
Suk-Kyeong
SK
Lee
Sang-Hyeup
SH
Kim
Hwan Mook
HM
Park
Song Kyu
SK
Lee
Ki Ho
KH
Lee
Chang Woo
CW
Ryu
Seong Eon
SE
Choi
Joong-Kwon
JK
D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry; D011485:Protein Binding; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000145:classification / Q000378:metabolism*; D012236:Rhodanine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000447:Aldehydes; D004791:Enzyme Inhibitors; D009281:Naphthalenes; C013243:salicylaldehyde; C031721:naphthalene; D012236:Rhodanine; D017027:Protein Tyrosine Phosphatases