Identification of degradation products from aqueous carboplatin injection samples by electrospray mass spectrometry.
Four different carboplatin injection samples in water ( approximately 10mg/ml) stored at room temperature were investigated for degradation products by electrospray liquid chromatography-mass spectrometry (ESI/LC-MS). A mass spectrometer compatible mobile phase system with 0.02% formic acid and methanol was used to resolve the impurities. Possible chemical structures of the unknown impurities and its degradation mechanism were proposed based on its experimental results and literature findings.
Vivekanandan
Kannan
K
Mass Spectrometry Lab, Dabur Research Foundation, 22 Site IV, Sahibabad, UP 201010, India. vivekanandan@dabur.com
Swamy
Madugundu Guru
MG
Prasad
Sudhanand
S
Maikap
Golak Chandra
GC
Mukherjee
Rama
R
Burman
Anand C
AC
D000970:Antineoplastic Agents / Q000737:chemistry*; D016190:Carboplatin / Q000737:chemistry*; D004355:Drug Stability; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization
D000970:Antineoplastic Agents; D012996:Solutions; D016190:Carboplatin