Acute laryngotracheobronchitis and associated transient hyperphosphatasemia: a new case of transient hyperphosphatasemia in early childhood.
We report the case of a 20-month old boy with markedly elevated serum alkaline phosphatase (ALP) levels, documented during an episode of acute laryngotracheobronchitis. Biochemical investigations and imaging studies revealed no evidence of bone or liver disease. Transient hyperphosphatasemia (TH) was confirmed when serum ALP levels normalized within 2 months. Several theories were suggested for TH pathophysiology, viral infections among them; the exact causes, however, remain unclear. It is important to recognize TH and avoid misdiagnosis and unnecessary investigations.
Eboriadou
Maria
M
4th Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece. eboriad@med.auth.gr
Skouli
Georgia
G
Panagopoulou
Paraskevi
P
Haidopoulou
Katerina
K
Makedou
Artemis
A
Varlamis
George
G
D000469:Alkaline Phosphatase / Q000097:blood*; D019819:Budesonide / Q000008:administration & dosage; D003440:Croup / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009330:Nebulizers and Vaporizers; D010760:Phosphorus Metabolism Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D016896:Treatment Outcome
D005938:Glucocorticoids; D007527:Isoenzymes; D019819:Budesonide; D000469:Alkaline Phosphatase; D008775:Methylprednisolone