Bath treatment of channel catfish with three broad-spectrum antibiotics.
Serum drug levels were measured in channel catfish following bath exposure to kanamycin, gentamicin and chloramphenicol. Kanamycin was absorbed at a rate sufficient to attain therapeutic blood levels in several treatment schedules. Therapeutic blood concentrations could not be attained with gentamicin or chloramphenicol following 24 hrs exposure at 80 and 100 microg/ml water concentrations, respectively.
Gilmartin
W G
WG
Naval Undersea Center Biomedical Group, Code 402, Undersea Sciences Department, Code 40 San Diego, California 92132, USA.
Camp
B J
BJ
Lewis
D H
DH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D001494:Baths; D002397:Catfishes / Q000097:blood* / Q000378:metabolism; D002701:Chloramphenicol / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D005393:Fish Diseases / Q000188:drug therapy*; D005839:Gentamicins / Q000493:pharmacokinetics; D007612:Kanamycin / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007612:Kanamycin; D002701:Chloramphenicol