Supramolecular catalysis of Strecker reaction in water under neutral conditions in the presence of beta-cyclodextrin.
An environmentally benign and highly efficient procedure for the nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction) has been developed under biomimetic conditions in water in the presence of beta-cyclodextrin to afford alpha-aminonitriles in quantitative yields. The use of cyclodextrin precludes the use of either acid or base, and the catalyst can be recycled a number of times without loss in activity.
Surendra
K
K
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Krishnaveni
N Srilakshmi
NS
Mahesh
A
A
Rao
K Rama
KR
D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
D009570:Nitriles; D047392:beta-Cyclodextrins; D014867:Water; C031215:betadex