Long-term seizure outcome following surgery for dysembryoplastic neuroepithelial tumor.
OBJECTIVE
Resection of dysembryoplastic neuroepithelial tumor (DNET) is thought to result in favorable seizure outcome, but long-term follow-up data are scarce. The authors present a review of 18 patients who underwent surgical removal of a DNET: 12 via temporal lobectomy and six via lesionectomy.


METHODS
The mean long-term follow up was 10.8 years (median 10.4 years, range 7.8 to 14.8 years), and results obtained during this time period were compared with previously reported short-term (mean 2.7 years) seizure outcome data. In the current study, 66.7% patients had an Engel Class I outcome and 55.6% had an Engel Class IA outcome compared with 77.8% and 55.6%, respectively. Temporal lobectomy (Engel Class I, 83.3%; Engel Class IA, 66.7%) led to a better seizure outcome than lesionectomy (Engel Classes I and IA, 33.3%). Two patients (11.1%) required repeated operation and both had an incomplete lesionectomy initially.


CONCLUSIONS
Results indicated that complete resection of a DNET leads to a favorable seizure outcome, with epilepsy cure in those who had experienced early postoperative seizure relief. Long-term seizure outcome after surgery is predictable based on the result of short-term follow up.
Chan
Chow Huat
CH
Neurosurgical Department, Austin Hospital, Heidelberg, Victoria, Australia.
Bittar
Richard G
RG
Davis
Gavin A
GA
Kalnins
Renate M
RM
Fabinyi
Gavin C A
GC
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000150:complications* / Q000601:surgery*; D012640:Seizures / Q000209:etiology* / Q000601:surgery*; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome