Technique for enhanced accuracy and reliability in non-human primate stereotaxy.
Despite the importance of enhancing the accuracy and reliability of non-human primate stereotaxy, a number of limitations exist using currently described techniques. To overcome these problems, we present a simple universally available approach that combines pre-operative magnetic resonance imaging and the non-surgical creation of reference points (teeth marking). We have found that this approach improves stereotaxic targeting reliability and permits accurate reproducible stereotaxic localization at time points distant from the pre-operative imaging.
Walbridge
Stuart
S
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1414, USA.
Murad
Gregory J A
GJ
Heiss
John D
JD
Oldfield
Edward H
EH
Lonser
Russell R
RR
D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011323:Primates / Q000033:anatomy & histology*; D012015:Reference Standards; D015203:Reproducibility of Results; D013238:Stereotaxic Techniques / Q000295:instrumentation*; D014070:Tooth / Q000033:anatomy & histology