PC Technology as a platform for drug delivery: from combination to conjugation.
Hydrogel polymers incorporating phosphorylcholine have found widespread use in the manufacture of medical devices with improved haemo- and biocompatibility. Examples include soft contact lenses or coatings for devices, such as coronary stents and extracorporeal circuits. The advent of drug-device combinations has prompted the application of PC Technology (Biocompatibles UK Ltd) as a bioinert drug delivery vehicle, particularly in the form of coatings, for targeted delivery from a device surface. The flexible polymer chemistry employed in the synthesis of these materials offers a range of molecular architectures that could find applicability in a wide variety of drug delivery applications, including micellar, vesicular and gel systems, and even drug conjugation.
Lewis
Andrew L
AL
Biocompatibles UK Ltd, Farnham Business Park, Weydon Lane, Farnham, Surrey, GU9 8QL, UK. andrew.Lewis@biocompatibles.com
D020099:Coated Materials, Biocompatible; D004247:DNA / Q000235:genetics / Q000378:metabolism; D008823:Micelles; D014677:Pharmaceutical Vehicles; D010767:Phosphorylcholine; D011108:Polymers
D020099:Coated Materials, Biocompatible; D008823:Micelles; D014677:Pharmaceutical Vehicles; D011108:Polymers; D010767:Phosphorylcholine; D004247:DNA