Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia.
Transmission of Plasmodium falciparum malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing activity (TRA) were measured upon arrival and at 6, 12, and 24 months. Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P. falciparum infections. The longitudinally sustained association between TRA and antibodies against Pfs48/45 (odds ratio [OR] = 3.74, 95% confidence interval [CI] = 1.51-9.29) and Pfs230 (OR = 3.72, 95% CI = 1.36-10.17) suggests that functional transmission reducing immunity is acquired after limited exposure to infection.
Bousema
J Teun
JT
Department of Medical Microbiology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands. t.bousema@ncmls.ru.nl
Roeffen
Will
W
van der Kolk
Mike
M
de Vlas
Sake J
SJ
van de Vegte-Bolmer
Marga
M
Bangs
Michael J
MJ
Teelen
Karina
K
Kurniawan
Liliana
L
Maguire
Jason D
JD
Baird
J Kevin
JK
Sauerwein
Robert W
RW
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000953:Antigens, Protozoan / Q000097:blood / Q000276:immunology*; D002648:Child; D015331:Cohort Studies; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008137:Longitudinal Studies; D016778:Malaria, Falciparum / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000635:transmission; D008562:Membrane Glycoproteins / Q000097:blood / Q000276:immunology*; D018512:Parasitemia / Q000453:epidemiology / Q000276:immunology / Q000635:transmission; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000097:blood / Q000276:immunology*; D016036:Seroepidemiologic Studies; D014171:Transients and Migrants
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D008562:Membrane Glycoproteins; C430263:Pfs230 antigen, Plasmodium falciparum; D015800:Protozoan Proteins; C084847:pfs48-45 protein, Plasmodium falciparum