[Study on percutaneous absorption of Xuetie Dingchuan Plaster].
OBJECTIVE
To filtrate prescription of the adhesive plaster, kind and amount of percutaneous absorption reagent, etc.


METHODS
In vitro percutaneous absorption of Xuetie Dingchuan Plaster was studied by HPLC using magnolin as the content of the marker substance, in the condition of equal effective component of samples, drawing graphs with time as abscissa and area of peak as ordinate.


RESULTS
40% ethanol was used as receptor liquid, prescription with Polyethylene Glycol 6000 as bases, azone as percutaneous absorption reagent. The amount of azone was 1.8%.


CONCLUSIONS
The prescription of Xuetie Dingchuan Plaster, with 1.8% azone as percutaneous absorption reagent, and Polyethylene Glycol 6000 as bases, is preferable.
Sun
Shuping
S
Research and Development Center of New Drugs and Marine Medication, Nanjing 210029.
Di Liuqing
Huang
Yaozhou
Y
Ni
Meihua
M
Liu
Jia
J
D000279:Administration, Cutaneous; D000818:Animals; D001381:Azepines / Q000008:administration & dosage / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000493:pharmacokinetics*; D000431:Ethanol; D005260:Female; D066298:In Vitro Techniques; D017705:Lignans; D008031:Lignin / Q000031:analogs & derivatives / Q000378:metabolism; D008081:Liposomes; D008297:Male; D051379:Mice; D012869:Skin Absorption / Q000187:drug effects*
D001381:Azepines; D004365:Drugs, Chinese Herbal; D017705:Lignans; D008081:Liposomes; C094148:magnolin; D000431:Ethanol; D008031:Lignin; D004121:Dimethyl Sulfoxide