[Free radical processes in patients with iron deficiency anemia treated with iron medication].
OBJECTIVE
To study the effects of iron salts drugs (ISD) sorbifer durules and ferro-folgamma on free radical processes in 44 patients with iron deficiency anemia (IDA).


METHODS
IDA was diagnosed as a rule in women with uterine myomas, endometriosis, dysfunctional hemorrhage and other menorragias. Generation of active oxygen forms (AOF) was estimated by hemoluminescence (CL) before and after therapy. Lipid peroxidation was assessed by malonic dialdehyde (MDA) in plasma, antiperoxide plasma activity (APA)--by CL intensity in interaction with nitric peroxide. The system of antioxidant defense in ISD treatment was estimated by the activity of key antioxidant enzymes: superoxidedismutase, glutathion peroxidase and catalase.


RESULTS
The studied ISD normalized hemoglobin 3-4 weeks after the treatment onset. MDA decreased. Generation of AOF and activity of plasmic antioxidant enzymes did not change much.


CONCLUSIONS
ISD modulate free radical processes without oxidant stress.
Dvoretskiĭ
L I
LI
Zaspa
E A
EA
Litvitskiĭ
P F
PF
Bolevich
S B
SB
Men'shova
N I
NI
D000293:Adolescent; D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005609:Free Radicals / Q000378:metabolism*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D005296:Ferrous Compounds; D005609:Free Radicals; D006454:Hemoglobins; D008054:Lipid Peroxides; C020748:ferrous sulfate