title: Enhancement of splenic glucose metabolism during acute malarial infection: correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria.
abstract: In the current study, to elucidate the clinical features of severe malaria, we performed whole-body positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) of Plasmodium coatneyi-infected acute-phase Japanese macaques. The infected monkeys clearly exhibited increase in splenic FDG uptake indicating marked enhancement of glucose metabolism. The standardized uptake values (SUVs) of the spleen in the infected monkeys were significantly higher than those in the uninfected monkey. At autopsy, splenomegaly was clearly present in all infected monkeys, and histopathologic findings included hyperplasia of lymphoid follicles in white pulp, a large number of activated macrophage, and congestion of parasitized red blood cells (PRBCs) and malaria pigments in red pulp. We suggest that increase in splenic glucose uptake may thus be closely related to activation of splenic clearance system against blood-stage malarial parasites.
authors.affiliation: Department of Tropical Medicine and Parasitology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. skawai@dokkyomed.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawai
authors.forename: Eiji
authors.initials: E
authors.lastname: Ikeda
authors.forename: Munehiro
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Jun
authors.initials: J
authors.lastname: Matsumoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higuchi
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Nasim
authors.initials: N
authors.lastname: Khan
authors.forename: Katsumi
authors.initials: K
authors.lastname: Tomiyoshi
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Ken
authors.initials: K
authors.lastname: Katakura
authors.forename: Keigo
authors.initials: K
authors.lastname: Endo
authors.forename: Hajime
authors.initials: H
authors.lastname: Matsuda
authors.forename: Mamoru
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism*; D006651:Histocytochemistry; D008251:Macaca; D008288:Malaria / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D018512:Parasitemia / Q000000981:diagnostic imaging / Q000378:metabolism / Q000469:parasitology; D010961:Plasmodium / Q000254:growth & development*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013154:Spleen / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000469:parasitology*; D013163:Splenomegaly / Q000469:parasitology
chemical_list: D001786:Blood Glucose; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose