title: [Stem cell perspectives in myocardial infarctions].
abstract: Myocardial infarction is the leading cause of congestive heart failure and death in industrializated countries. The cellular cardiomyoplasty has emerged as an alternative treatment in the regeneration of infarted myocardial tissue. In animals' models, different cellular lines such as cardiomyocites, skeletal myoblasts, embryonic stem cells and adult mesenchymal stem cells have been used, resulting in an improvement in ventricular function and decrease in amount of infarcted tissue. The first three cells lines have disvantages as they are allogenics and are difficult to obtain. The adult mesenchymal stem cells are autologous and can be obtained throught the aspiration of bone marrow or from peripherical circulation, after stimulating with cytokines (G-CSF). The implantation in humans with recent and old myocardial infarction have shown improvements similar to those shown in animal models. These findings encourage the continued investigation in the mechanism of cellular differentiation and implantation methods in infarcted myocardial tissue.
authors.affiliation: División de Cirugía Cardiaca y Cardiología, Hematología, Ecocardiografía y Medicina Nuclear del CMN 20 de Noviembre ISSSTE, México, DF. aceves996@hotmail.com
authors.forename: José Luis
authors.initials: JL
authors.lastname: Aceves
authors.forename: Abel
authors.initials: A
authors.lastname: Archundia
authors.forename: Guillermo
authors.initials: G
authors.lastname: Díaz
authors.forename: Araceli
authors.initials: A
authors.lastname: Páez
authors.forename: Felipe
authors.initials: F
authors.lastname: Masso
authors.forename: Martha
authors.initials: M
authors.lastname: Alvarado
authors.forename: Manuel
authors.initials: M
authors.lastname: López
authors.forename: Rocío
authors.initials: R
authors.lastname: Aceves
authors.forename: Carlos
authors.initials: C
authors.lastname: Ixcamparij
authors.forename: Adriana
authors.initials: A
authors.lastname: Puente
authors.forename: Rafael
authors.initials: R
authors.lastname: Vilchis
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Montaño
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006133:Growth Substances / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000473:pathology / Q000601:surgery*; D032383:Myocytes, Cardiac / Q000166:cytology; D013234:Stem Cells / Q000145:classification; D014182:Transplantation, Autologous
chemical_list: D006133:Growth Substances; D016179:Granulocyte Colony-Stimulating Factor