Reaction to the paper: interaction of polysorbate 80 with erythropoietin: a case study in protein-surfactant interactions.
Micelle-associated epoetin is still a possible explanation for the upsurge of pure red blood cell aplasia associated with subcutaneous use of epoetin alpha in patients with chronic renal failure.
Hermeling
Suzanne
S
Jiskoot
Wim
W
Crommelin
Daan J A
DJ
Schellekens
Huub
H
D002626:Chemistry, Pharmaceutical; D004356:Drug Storage; D000068817:Epoetin Alfa; D004921:Erythropoietin / Q000737:chemistry*; D006397:Hematinics / Q000737:chemistry*; D008823:Micelles; D011136:Polysorbates / Q000737:chemistry*; D011994:Recombinant Proteins; D013501:Surface-Active Agents / Q000737:chemistry*; D013594:Syringes
D006397:Hematinics; D008823:Micelles; D011136:Polysorbates; D011994:Recombinant Proteins; D013501:Surface-Active Agents; D004921:Erythropoietin; D000068817:Epoetin Alfa