title: A t(12;17) in an extraorbital giant cell angiofibroma.
abstract: We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103, USA. kevin_chian@yahoo.com
authors.forename: You-Wen
authors.initials: YW
authors.lastname: Qian
authors.forename: Rajit
authors.initials: R
authors.lastname: Malliah
authors.forename: Huey-Jen
authors.initials: HJ
authors.lastname: Lee
authors.forename: Kasturi
authors.initials: K
authors.lastname: Das
authors.forename: Neena
authors.initials: N
authors.lastname: Mirani
authors.forename: Meera
authors.initials: M
authors.lastname: Hameed
mesh_terms: D000328:Adult; D018322:Angiofibroma / Q000235:genetics* / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic