title: Delayed hyperenhancement magnetic resonance imaging is useful in predicting functional recovery of nonischemic left ventricular systolic dysfunction.
abstract: BACKGROUND
  About 25% of the patients with nonischemic left ventricular (LV) systolic dysfunction improve spontaneously. However, the predictors for functional improvement are not known. We hypothesized that myocardial fibrosis, assessed by cardiac magnetic resonance (CMR) imaging, may predict the reversibility of nonischemic LV systolic dysfunction.
  
  
  RESULTS
  CMR was performed in 46 patients. Baseline and follow-up echocardiography was performed to assess the recovery of LV function. There were 24 patients with absence of delayed hyperenhancement (group 1) and 22 patients with delayed hyperenhancement (group 2). There were significant difference for the follow-up LV end-diastolic dimension (56.2 +/- 7.3 versus 62.6 +/- 11.9), LV end-systolic dimension (43.2 +/- 9.2 versus 52.8 +/- 12.6), and LV ejection fraction (LVEF) (46.8 +/- 12.4% versus 31.6 +/- 11.3%). Follow-up echocardiography of 19/24 (79.2%) patients in group 1 showed functional recovery, whereas only 2/22 (9.1%) patient in group 2 showed functional recovery. The absence of delayed hyperenhancement was associated with sensitivity, specificity, positive predictive value, and negative predictive value of 90.5%, 79.2%, 80.0%, and 90.9%, respectively.
  
  
  CONCLUSIONS
  Absence of delayed hyperenhancement demonstrated excellent sensitivity and negative predictive value in predicting functional recovery of nonischemic LV systolic dysfunction.
authors.affiliation: Division of Cardiology, Yonsei University College of Medicine, Yonsei Cardiovascular Center, Seodaemun-gu, Shinchondong, Seoul, South Korea 120-752.
authors.forename: Sungha
authors.initials: S
authors.lastname: Park
authors.forename: Byoung Wook
authors.initials: BW
authors.lastname: Choi
authors.forename: Se-Joong
authors.initials: SJ
authors.lastname: Rim
authors.forename: Chi Young
authors.initials: CY
authors.lastname: Shim
authors.forename: Young-Guk
authors.initials: YG
authors.lastname: Ko
authors.forename: Seok-Min
authors.initials: SM
authors.lastname: Kang
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Ha
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Namsik
authors.initials: N
authors.lastname: Chung
authors.forename: Kyu-Ok
authors.initials: KO
authors.lastname: Choe
authors.forename: Seung-Yun
authors.initials: SY
authors.lastname: Cho
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology*; D016022:Case-Control Studies; D003287:Contrast Media; D018618:Echocardiography, Doppler, Color; D005260:Female; D005355:Fibrosis; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D020127:Recovery of Function / Q000502:physiology*; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000473:pathology / Q000503:physiopathology*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA