title: Application of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imaging.
abstract: A saturation-based approach is proposed to image the arterial blood flow signal with temporal resolution of 1 to 2 s and in-plane spatial resolution of a few millimeters. Using a saturation approach to suppress the undesired background stationary signal allows the blood water that enters the slice to be imaged at some specified later time. Since the blood protons that are being imaged are not restricted to the intravascular space, this technique is also sensitive to tissue perfusion signal contributions. The signal uptake characteristics of the saturation method proposed were used to study the different signal contributions as a function of the acquisition parameters. A typical perfusion acquisition (FAIR) was also used for comparison. The proposed method was demonstrated in a functional motor activation experiment and the observed signal changes were smaller than those obtained using the FAIR acquisition. The dynamics of the saturation method and FAIR temporal signal changes were investigated and time constants between 2 and 44 s were estimated. The tissue signal contribution to the saturation method's signal was small over the range of acquisition parameters that sensitized it to the arterial compartment.
authors.affiliation: Functional MRI Laboratory, University of Michigan, Ann Arbor, Michigan 48109-2108, USA. towi@umich.edu
authors.forename: Alberto L
authors.initials: AL
authors.lastname: Vazquez
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Lee
authors.forename: Luis
authors.initials: L
authors.lastname: Hernandez-Garcia
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Noll
mesh_terms: D002560:Cerebrovascular Circulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009043:Motor Activity; D013113:Spin Labels; D013382:Subtraction Technique; D013997:Time Factors
chemical_list: D013113:Spin Labels