[Influence of 4-nitrophenol on some biochemical and morphological indices of rat blood].
Influence of different doses of 4-nitrophenol on some biochemical and morphological indices of rat blood was studied. Glucose and beta-lipoprotein concentration increased, but total protein concentration decreased in response to intraperitoneal injection of xenobiotic. As a result of xenobiotic action, the total amount of leukocytes and thrombocytes increased, while the amount of erythrocytes decreased. The morphological study of structural indices of blood formed elements has demonstrated, that intensity of the defensive response of blood formed elements was 4-nitrophenol dose-dependent.
Arziani
B A
BA
Tushurashvili
P R
PR
Chikhladze
Ts K
TsK
Dzhodadze
R G
RG
Kumsiashvili
N I
NI
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D018876:Environmental Illness / Q000097:blood* / Q000139:chemically induced; D004912:Erythrocytes / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007962:Leukocytes / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000097:blood* / Q000187:drug effects; D008297:Male; D009596:Nitrophenols / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D001786:Blood Glucose; D008077:Lipoproteins, LDL; D009596:Nitrophenols; C024836:4-nitrophenol