title: Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma.
abstract: The Adacolumn is an adsorptive-type extracorporeal device, which is filled with cellulose diacetate beads that selectively adsorb granulocytes and monocytes. Patients with severe persistent asthma experience highly variable continuous symptoms and severe exacerbations in spite of medication based on inhaled glucocorticosteroids. Granulocyte and monocyte adsorption apheresis using extracorporeal circulation through the Adacolumn was performed in nine patients with severe persistent asthma. The extracorporeal circulation through the Adacolumn was performed once a week for 5 weeks. We were able to perform this therapy without any severe adverse effects in all patients, although one patient complained of general fatigue just after the circulations. In six of the nine patients, the increase in peak expiratory flow (PEF) was more than 50 mL/min. The average increase in morning PEF was 23.3% while that in the evening PEF was 26.4% after the therapy. This therapy was not harmful for patients with severe persistent asthma. A placebo-controlled study will be desired to evaluate the efficacy of this nonpharmacological strategy accurately.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan. tamotsui@showa.gunma-u.ac.jp
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Ishizuka
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Kawata
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Utsugi
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Endou
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hisada
authors.forename: Kunio
authors.initials: K
authors.lastname: Dobashi
authors.forename: Tsugio
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000327:Adsorption; D000328:Adult; D000368:Aged; D001249:Asthma / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006098:Granulocytes; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome