title: Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineage.
abstract: A relatively high rate of vancomycin-resistant Enterococcus faecium not susceptible to linezolid was observed in intensive care unit patients. Linezolid-resistant isolates carried the G2576T mutation in the 23S rRNA gene, belonged to different clones, and shared the same allelic profile, which clusters in the C1 multilocus sequence typing epidemic lineage.
authors.affiliation: Dipartimento di Patologia, Sezione di Microbiologia, Università di Verona, Strada Le Grazie 8, 37100 Verona, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bonora
authors.forename: Maurizio
authors.initials: M
authors.lastname: Solbiati
authors.forename: Erminia
authors.initials: E
authors.lastname: Stepan
authors.forename: Antonella
authors.initials: A
authors.lastname: Zorzi
authors.forename: Aldo
authors.initials: A
authors.lastname: Luzzani
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Catania
authors.forename: Roberta
authors.initials: R
authors.lastname: Fontana
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000483:Alleles; D001483:Base Sequence; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016984:Enterococcus faecium / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007362:Intensive Care Units; D007558:Italy / Q000453:epidemiology; D000069349:Linezolid; D017720:Molecular Epidemiology; D023303:Oxazolidinones / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000235:genetics; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D020713:Vancomycin Resistance / Q000235:genetics
chemical_list: D000081:Acetamides; D004269:DNA, Bacterial; D023303:Oxazolidinones; D012329:RNA, Bacterial; D012338:RNA, Ribosomal, 23S; D000069349:Linezolid