N-Benzylbenzamides: a new class of potent tyrosinase inhibitors.
A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC(50) of 2.2microM.
Cho
Sung Jin
SJ
Marine Biotechnology Laboratory, School of Earth and Environmental Sciences, Seoul National University, Seoul 151-747, Republic of Korea.
Roh
Jung Seop
JS
Sun
Won Suck
WS
Kim
Sung Han
SH
Park
Ki Duk
KD
D001549:Benzamides / Q000494:pharmacology; D002384:Catalysis; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007980:Levodopa / Q000037:antagonists & inhibitors / Q000737:chemistry; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010084:Oxidation-Reduction
D001549:Benzamides; D004791:Enzyme Inhibitors; D007980:Levodopa; C037689:benzamide; D014442:Monophenol Monooxygenase