title: Technique for enhanced accuracy and reliability in non-human primate stereotaxy.
abstract: Despite the importance of enhancing the accuracy and reliability of non-human primate stereotaxy, a number of limitations exist using currently described techniques. To overcome these problems, we present a simple universally available approach that combines pre-operative magnetic resonance imaging and the non-surgical creation of reference points (teeth marking). We have found that this approach improves stereotaxic targeting reliability and permits accurate reproducible stereotaxic localization at time points distant from the pre-operative imaging.
authors.affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1414, USA.
authors.forename: Stuart
authors.initials: S
authors.lastname: Walbridge
authors.forename: Gregory J A
authors.initials: GJ
authors.lastname: Murad
authors.forename: John D
authors.initials: JD
authors.lastname: Heiss
authors.forename: Edward H
authors.initials: EH
authors.lastname: Oldfield
authors.forename: Russell R
authors.initials: RR
authors.lastname: Lonser
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011323:Primates / Q000033:anatomy & histology*; D012015:Reference Standards; D015203:Reproducibility of Results; D013238:Stereotaxic Techniques / Q000295:instrumentation*; D014070:Tooth / Q000033:anatomy & histology