[Pharmacokinetic characteristics of ferulic acid in patients with different syndromes of deficiency of spleen qi, stagnation of liver qi and spleen deficiency, and excess of stomach heat].
OBJECTIVE
To investigate the nature of syndrome of traditional Chinese medicine by means of pharmacokinetic (PK) method.


METHODS
Twenty-one healthy volunteers, 20 patients with syndrome of stagnation of liver qi and spleen deficiency, 22 patients with syndrome of deficiency of spleen qi and 19 patients with syndrome of excess of stomach heat were included and administered to take Jiawei Xiaoyaosan Recipe (JWXYSR). The serum PK parameters of ferulic acid (FA) were examined by high performance liquid chromatography (HPLC) method.


RESULTS
The absorption rate constant (alpha) and the elimination rate constant (beta) were both decreased while the apparent first-order absorption constant (K(a)) was enhanced significantly in the patients with syndrome of deficiency of spleen qi; the alpha, beta and Ka were all reduced in the patients with syndrome of stagnation of liver qi and spleen deficiency; the beta and K(a) were increased in the patients with syndrome of excess of stomach heat, as compared with the corresponding PK parameters in the healthy volunteers (P<0.01).


CONCLUSIONS
The PK analysis of FA in the patients with syndrome of deficiency of spleen qi shows that the absorption rate is accelerated, and both the distribution and elimination rates are slowed down. The absorption, distribution and elimination rates of AF are all slowed down in the patients with syndrome of stagnation of liver-qi and spleen deficiency, while the absorption and elimination rates of AF are both accelerated in the patients with syndrome of excess of stomach heat. There are obvious differences in the PK characteristics among these three syndromes.
Ren
Ping
P
Department of General Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China. renping3@163.com
Huang
Xi
X
Li
Shuang-Qing
SQ
Xu
Shu-Yun
SY
Wan
Mei-Hua
MH
Zhou
Ya-Xiong
YX
Zhou
Yi-Wu
YW
Tang
Wen-Fu
WF
D000328:Adult; D003373:Coumaric Acids / Q000493:pharmacokinetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000378:metabolism; D019413:Qi; D013154:Spleen; D016711:Yang Deficiency / Q000188:drug therapy / Q000378:metabolism
D003373:Coumaric Acids; C004999:ferulic acid