title: A randomized trial comparing oral misoprostol with intra-amniotic prostaglandin F2alpha for second trimester terminations.
abstract: OBJECTIVE
  To compare the efficacy of oral misoprostol with that of intra-amniotic prostaglandin F2alpha (PGF2alpha) for second trimester pregnancy termination.
  
  
  METHODS
  One hundred seventeen women with pregnancies of between 16 and 22 weeks' gestation were randomly assigned after insertion of laminaria to receive either oral misoprostol 400 microg every 4 hours (to a maximum of four doses) or intra-amniotic PGF2alpha 40 mg. The rate of complete abortion within 24 hours was the primary outcome for power analysis. Secondary outcome measures were the rate of dilatation and curettage (D&C) for retained placenta and the rates of fever and gastrointestinal complications.
  
  
  RESULTS
  Patient characteristics were similar in both groups. The rate of complete abortion within 24 hours was similar in the misoprostol (63%) and PGF2alpha (66%) groups. The rate of retained placenta requiring D&C was significantly greater in the PGF2alpha group (22.4% vs. 3.4%, P = 0.002). There were no differences in other maternal morbidities. Parous patients treated with oral misoprostol had a significantly greater rate of complete abortion than nulliparous patients (84% vs. 57%, P = 0.04).
  
  
  CONCLUSIONS
  Oral misoprostol is as effective as intra-amniotic PGF2alpha for second trimester pregnancy termination when laminaria is inserted before treatment. Parous patients have a higher success rate than nulliparous patients with use of oral misoprostol. Oral misoprostol is associated with a very low rate of placental retention.
authors.affiliation: University of British Columbia, British Columbia Women's Hospital and Health Centre, Vancouver, BC.
authors.forename: Gerald P
authors.initials: GP
authors.lastname: Marquette
authors.forename: M Amanda
authors.initials: MA
authors.lastname: Skoll
authors.forename: Lorraine
authors.initials: L
authors.lastname: Dontigny
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000592:standards*; D000028:Abortion, Induced; D000284:Administration, Oral; D000328:Adult; D000653:Amniotic Fluid; D015237:Dinoprost / Q000592:standards*; D005260:Female; D006801:Humans; D007795:Laminaria; D016595:Misoprostol / Q000592:standards*; D010298:Parity; D018457:Placenta, Retained / Q000453:epidemiology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; D015237:Dinoprost