title: [Diagnostic value of definition of lactate dehydrogenase in mixed saliva in children with periodontitis at diabetes mellitus, type I].
abstract: The problem of treatment of periodontitis remains one of the hot topics in practical stomatology. It has been established that modern adaptogenic infection is rather aggressive to whole organism of a human being. All these demands accurate approach while choosing of a conservative method of treatment for such forms as acute and chronic periodontitis. There were 27 children under observation with diabetes mellitus of type 1 (I group). Mean age was 10.5+/-0.75 years. 15 were girls and 13 boys. All patients from the I group were examined for the pathologies of oral cavity. In 100% dryness in a mouth and in 67% bleeding from the gum had been revealed. The mild form of chronic catarrhal gingivitis was revealed in 12 patients, moderate in 5, chronic hypertrophic gingivitis in 8 respectively. Studying of pH of saliva and lactate dehydrogenase (LDH) activity in children with periodontitis developed on the background of recently diagnosed type 1 diabetes mellitus has shown, that pH of saliva was equal to 5.3+/-0.18. In control group (healthy children) pH of saliva was 6.8+/-0.06. In the conclusion it should be emphasized, that we have tried to explain some aspects of multiple character of development of periodontitis at recently discovered insulin-depended diabetes mellitus. Character of changes of some properties of saliva pH and of enzyme activity of LDG promotes to carrying out medical and preventive actions, influencing the main blocks of pathogenesis of this pathological process. Besides, we consider possibility of inclusion the studied parameters of mixed saliva in the algorithm of investigation of periodontitis in children with recently diagnosed type 1 diabetes mellitus.
authors.forename: E M
authors.initials: EM
authors.lastname: Chidzhavadze
authors.forename: M V
authors.initials: MV
authors.lastname: Akhvlediani
authors.forename: Z O
authors.initials: ZO
authors.lastname: Vadachkoriia
authors.forename: M R
authors.initials: MR
authors.lastname: Gordeladze
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000201:enzymology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D010518:Periodontitis / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology; D012463:Saliva / Q000201:enzymology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D007770:L-Lactate Dehydrogenase