title: Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy.
abstract: Fat-selective MRI was applied to assess the amount and spatial distribution of hepatic lipids (HL) in healthy subjects. The results were compared with those obtained by localized 1H-MR spectroscopy (MRS). Ninety subjects (23-63 years old) underwent single-slice fat-selective MRI with spatial-spectral excitation and volume-localized spectroscopy at 1.5 T. HLs were analyzed in ventral and dorsal regions of interest (ROIs) of the liver in fat-selective images. Spectra were evaluated using the integral signal of methylene and methyl signals. The fat-selective images showed smooth and homogeneous distribution of HL over the entire cross section of the liver. There was, however, a marked interindividual variability in the amount of HL. MRS revealed a lipid signal fraction between 0.5% and 39.3%. The fat content in the ROIs in images correlated well with the spectroscopic results (r >or= 0.95). Both techniques provide sufficient sensitivity for a reliable and quantitative assessment of liver steatosis in subjects without liver disease. 1H-MRS has a higher sensitivity compared to MRI, especially for small amounts of HL, which may be of interest for metabolic interventions. Fat-selective images provide more spatial information about fat distribution, which makes this technique suitable for clinical imaging of patients with liver disease.
authors.affiliation: Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tübingen, Tübingen, Germany. juergen.machann@med.uni-tuebingen.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Machann
authors.forename: Claus
authors.initials: C
authors.lastname: Thamer
authors.forename: Birgit
authors.initials: B
authors.lastname: Schnoedt
authors.forename: Norbert
authors.initials: N
authors.lastname: Stefan
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Haring
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Andreas
authors.initials: A
authors.lastname: Fritsche
authors.forename: Fritz
authors.initials: F
authors.lastname: Schick
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005234:Fatty Liver / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results