title: Bilateral oscillations for lateralized spikes in benign rolandic epilepsy.
abstract: OBJECTIVE
  To elucidate the oscillatory dynamics with respect to interictal spike occurrence in benign rolandic epilepsy (BRE).
  
  
  METHODS
  Using a whole-scalp magnetoencephalography (MEG), we recorded scalp EEG and MEG signals in 10 BRE patients (age 8-12 years) and visually identified unilateral interictal spikes that were simultaneously present on both EEG and MEG channels. We obtained the peak timing of individual spike complex based on MEG single-dipole modeling, and then applied wavelet transform to analyze the time-frequency components of corresponding MEG signals with respect to spike occurrence.
  
  
  RESULTS
  In the hemisphere with time-domain spike waveforms, we identified a clear increase of 0.5-40 Hz activity around the spike peak, most prominent at alpha band (8-13 Hz). Notably, at the approximate timing we also observed an increase in 0.5-25 Hz oscillations over the homotopic area in the other hemisphere where no spike signals were found.
  
  
  CONCLUSIONS
  Our results indicate bilateral increases in 0.5-25 Hz oscillations during unilateral spike formation in BRE patients. By using wavelet transform analysis, one could be able to detect some irritative feature that would in visual analysis remain undetected.
authors.affiliation: Institute of Physiology, National Yang-Ming University, Taipei, Taiwan. yylin@vghtpe.gov.tw
authors.forename: Yung-Yang
authors.initials: YY
authors.lastname: Lin
authors.forename: Fu-Jung
authors.initials: FJ
authors.lastname: Hsiao
authors.forename: Kai-Ping
authors.initials: KP
authors.lastname: Chang
authors.forename: Zin-An
authors.initials: ZA
authors.lastname: Wu
authors.forename: Low-Tone
authors.initials: LT
authors.lastname: Ho
mesh_terms: D002648:Child; D004569:Electroencephalography / Q000379:methods; D004594:Electrophysiology; D019305:Epilepsy, Rolandic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D012815:Signal Processing, Computer-Assisted