title: Newer therapeutic approaches: gout.
abstract: Newer approaches to the treatment of gout have included modifications and further attention to aspects of current therapies, and development of interesting new therapies. Colchicine prophylaxis appears to be needed longer than previously recognized after introduction of a urate-lowering agent. Diet has received attention, though most dietary effects are small. New agents under investigation include pegylated formulations of uricase and a new potent xanthine oxidase inhibitor, febuxostat. Some cardiovascular drugs have been shown to be uricosuric.
authors.affiliation: Division of Rheumatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA. schumacr@mail.med.upenn.edu
authors.forename: H Ralph
authors.initials: HR
authors.lastname: Schumacher
authors.forename: Lan X
authors.initials: LX
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015210:Arthritis, Gouty / Q000188:drug therapy*; D000069465:Febuxostat; D006801:Humans; D013844:Thiazoles / Q000627:therapeutic use; D014503:Urate Oxidase / Q000627:therapeutic use; D014528:Uricosuric Agents / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D013844:Thiazoles; D014528:Uricosuric Agents; C469709:rasburicase; D000069465:Febuxostat; D014969:Xanthine Oxidase; D014503:Urate Oxidase