title: Asymptomatic carotid lesions and aging: Role of hypertension and other traditional and emerging risk factors.
abstract: BACKGROUND
  We evaluated the prevalence of intima-media thickening (IMT) and asymptomatic carotid plaque (ACP) in a group of subjects with or without traditional and/or emerging risk factors (RF).
  
  
  METHODS
  There were 631 subjects (313 male and 318 female) aged between 19 and 97 years, asymptomatic for cerebro- and cardiovascular diseases. The following measurements were used: anamnesis, physical examination, height and sitting blood pressure. Biochemistry variables were also considered: total cholesterol, HDL-C, LDL-C, triglycerides, fibrinogen, high sensitive C-reactive protein, IgG antibodies for Helicobacter pylori (HP), cytotoxic HP, cytomegalovirus and Chlamydia pneumoniae. Finally, an echo color Doppler examination of the carotid arteries was performed. We subdivided the population studied in normotensive and hypertensive subjects and evaluated in each group the frequency of IMT and ACP in relation to age.
  
  
  RESULTS
  We showed that IMT + ACP was significantly more frequent in patients >65 years in comparison with those <65 years (80.6 vs. 52.1%, p < 0.005) and in hypertensive patients in comparison to normotensive, independent of coexistence of other cardiovascular risk factors (71 vs. 48%, p < 0.005). Another interesting result of our study is a significant presence of IMT and ACP in subjects with emerging but without traditional RF than in subjects with traditional but without emerging RF.
  
  
  CONCLUSIONS
  IMT and ACP of carotid arteries are significantly more frequent in patients >65 years vs. those <65 years and in hypertensive patients in comparison to controls. Finally, we have found that the seropositivity of infection and the presence of higher levels of marker of inflammation were correlated with carotid lesion.
authors.affiliation: Chair of Cardiovascular Diseases, Department of Internal Medicine, Cardiovascular and NefroUrological Diseases, University of Palermo, Italy.
authors.forename: Glauco
authors.initials: G
authors.lastname: Milio
authors.forename: Egle
authors.initials: E
authors.lastname: Corrado
authors.forename: Daniela
authors.initials: D
authors.lastname: Sorrentino
authors.forename: Ida
authors.initials: I
authors.lastname: Muratori
authors.forename: Salvatore
authors.initials: S
authors.lastname: La Carrubba
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mazzola
authors.forename: Rosalba
authors.initials: R
authors.lastname: Tantillo
authors.forename: Giustina
authors.initials: G
authors.lastname: Vitale
authors.forename: Serafino
authors.initials: S
authors.lastname: Mansueto
authors.forename: Salvatore
authors.initials: S
authors.lastname: Novo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000473:pathology; D002340:Carotid Artery Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014463:Ultrasonography