title: Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes.
abstract: We demonstrate the self-assembly of DNA and DNA binding proteins into two-dimensional networks that are then addressable by sending a second protein to a specific recognition site on the DNA network. These networks cover centimeters in area but can be addressed with nanometer precision. This hierarchical self-assembly of specific DNA protein complexes will be the basis for complex positioning of single molecules in two and three dimensions.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Maximino
authors.initials: M
authors.lastname: Manzanera
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Frankel
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.forename: Dejian
authors.initials: D
authors.lastname: Zhou
authors.forename: Andreas
authors.initials: A
authors.lastname: Bruckbauer
authors.forename: Peter
authors.initials: P
authors.lastname: Kreutzmann
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Blackburn
authors.forename: Chris
authors.initials: C
authors.lastname: Abell
authors.forename: Trevor
authors.initials: T
authors.lastname: Rayment
authors.forename: David
authors.initials: D
authors.lastname: Klenerman
authors.forename: Paul D
authors.initials: PD
authors.lastname: Barker
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure*; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D016328:NF-kappa B / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure*; D013057:Spectrum Analysis
chemical_list: D016328:NF-kappa B; D011506:Proteins; D004247:DNA