title: Valvular heart disease in pregnancy.
abstract: Women with valvular disease who are pregnant or planning to conceive require careful evaluation and management. Pregnancy is associated with normal physiologic changes that can aggravate many valvular conditions and may require the initiation or increase of cardiovascular medications to manage fluid overload or arrhythmias. Most women will tolerate pregnancy and delivery without major complication, though some types of valvular heart disease are poorly tolerated and require more intensive management, or even termination of the pregnancy. In addition, patients at risk of thromboembolism and those who have prosthetic cardiac valves require anticoagulation. The decision regarding the choice and intensity of anticoagulation requires careful balance between the individual risks of thrombosis and bleeding in the mother and harm to the fetus.
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02461, USA.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Scirica
authors.forename: Patrick T
authors.initials: PT
authors.lastname: O'Gara
mesh_terms: D005260:Female; D006349:Heart Valve Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D012307:Risk Factors