Intrinsically radiopaque iodine-containing polyvinyl alcohol as a liquid embolic agent: evaluation in experimental wide-necked aneurysms.
OBJECTIVE
To evaluate iodine-containing polyvinyl alcohol (I-PVA) as a precipitating liquid embolic agent, implant characteristics--including radiopacity, setting behavior, and biocompatibility--were studied in an aneurysm model in swine.


METHODS
Twelve broad-based carotid artery (CA) sidewall aneurysms were surgically constructed in six pigs. Iodine-containing polyvinyl alcohol dissolved in dimethyl sulfoxide (DMSO) was injected during temporary balloon occlusion bridging the aneurysm neck. Control angiography as well as multidetector row computerized tomography (CT) angiography was performed after 4 weeks. Harvested aneurysms were investigated histopathologically and by 3-tesla high-field magnetic resonance (MR) imaging. The mean degree of aneurysm occlusion achieved was 96%. In two aneurysms a minimal protrusion of I-PVA into the CA lumen was observed. During one embolization, leakage of the liquid embolic agent due to DMSO-induced damage of the microcatheter resulted in CA occlusion. Aneurysms embolized with I-PVA could be discriminated clearly from the parent artery on CT angiograms because there was no beam-hardening artifact. High-field MR imaging allowed a detailed depiction of the liquid embolic distribution within the aneurysm. Histologically, a mild to moderate inflammatory response was found in successfully embolized aneurysms, and the polymer mass was frequently covered by a membrane of fibroblasts and endothelial cells.


CONCLUSIONS
Iodine-containing polyvinyl alcohol is a ready-to-use liquid embolic agent clearly visible under fluoroscopy; additives are not required. The setting behavior allows for controlled delivery in aneurysm cavities. Histological studies performed 4 weeks after embolization revealed no sign of toxic tissue response to the liquid embolic agent. Overall, I-PVA exhibits interesting implant characteristics in that radiopaque admixtures are not necessary, thus allowing for artifact-free evaluation of treated aneurysms by using CT and MR angiography.
Dudeck
Oliver
O
Department of Radiology, Charité, Campus Virchow Clinic, Berlin, Germany. oliver.dudeck@charite.de
Jordan
Olivier
O
Hoffmann
Karl-Titus
KT
Tesmer
Kai
K
Kreuzer-Nagy
Tibor
T
Podrabsky
Petr
P
Heise
Michael
M
Meyer
Rudolf
R
Okuducu
Ali Fuat
AF
Bruhn
Harald
H
Hilborn
Jöns
J
Rüfenacht
Daniel A
DA
Doelker
Eric
E
Felix
Roland
R
D000783:Aneurysm / Q000628:therapy*; D000818:Animals; D002340:Carotid Artery Diseases / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005471:Fluoroscopy; D007455:Iodine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018810:Magnetic Resonance Angiography; D011142:Polyvinyl Alcohol / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013552:Swine; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D011142:Polyvinyl Alcohol; D007455:Iodine