[Amyotrophic lateral sclerosis in younger age associated with abnormality of copper level].
Amyotrophic lateral sclerosis is a progressive degenerative neuromuscular disease in adults that occurs in familial and sporadic forms. The mean age of onset of symptoms is 56 years and the mean duration of disease is 3 years. One of the theories on the pathogenesis suggests on mutation in gene that encodes superoxide dismutase, which is involved in metabolism of free radicals (copper, zinc). In this article we showed patient with early onset of disease associated with abnormality of copper level. Co morbidity with Wilson disease has not been proved. According to this case it is possible to think about changes in cuprum level at ALS patients.
Ibrahimagić
Omer C
OC
Klinika za Neurologiju, Univerzitetski Klinicki Centar Tuzla.
Sinanović
Osman
O
Zonić
Lejla
L
Hudić
Josip
J
D000328:Adult; D017668:Age of Onset; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D003300:Copper / Q000097:blood*; D006801:Humans; D008297:Male
D003300:Copper