Alpha-glucosidase inhibitory and antioxidant acridone alkaloids from the stem bark of Oriciopsis glaberrima ENGL. (Rutaceae).
The CH2Cl2/MeOH extract of the stem bark of Oriciopsis glaberrima ENGL. afforded four new acridone alkaloids namely oriciacridone C, D, E and F along with six known compounds: atalaphyllidine, oleanolic acid, butulinic acid, beta-sitosterol, stigmasterol, glucoside of stigmasterol and one synthetically known acridone: 1,3,5-trihydroxy-4-prenylacridone. The structures were established on the basis of MS, 1D and 2D NMR experiments. The acridones 1, 4 and 5 showed potent activity against alpha-glucosidase, while the acridones 1-5 showed moderate free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).
Wansi
Jean Duplex
JD
Department of Chemistry, University of Douala, Faculty of Science, Cameroon. jdwansi@yahoo.fr
Wandji
Jean
J
Mbaze Meva'a
Luc
L
Kamdem Waffo
Alain François
AF
Ranjit
Rose
R
Khan
Shamsun Nahar
SN
Asma
Azaz
A
Iqbal
Choudhary Muhammad
CM
Lallemand
Marie-Christine
MC
Tillequin
François
F
Fomum Tanee
Zacharias
Z
D000166:Acridines / Q000737:chemistry* / Q000494:pharmacology*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000166:Acridines; D000470:Alkaloids; D000975:Antioxidants; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D065089:Glycoside Hydrolase Inhibitors; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl