[Effects of experimental varicocele on methylenedioxyamphetamine, total antioxidants content and sialic acid of the epididymis in adolescent rats].
OBJECTIVE
To explore the changes of methylenedioxyamphetamine (MDA), total antioxidants content (TAC) and sialic acid (SA) from the unilateral epididymis of experimental varicocele in adolescent rats, and to illuminate the effects of varicocele on unilateral epididymis epithelium.


METHODS
Experimental left varicocele model of 16 adult male Sprague-Dawley rats were established by partial ligation of left renal vein. The epididymis were collected for detecting the content of MDA, TAC and SA by using spectrophotometry.


RESULTS
There was statistically significant differences in the contents of three substances between experimental varicocele and sham-operated groups.


CONCLUSIONS
The content of MDA, TAC and SA will change and the sialic acid-secreting-function of unilateral epididymis will be injured because of varicocele.
Zhao
Yu-Gang
YG
Department of Urology, Xiangfan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science & Technology, Xiangfan, Hubei 441021, China. zhaoyugang@21cn.com
Shi
Hong-Bo
HB
Zhang
Xue-Jun
XJ
Zhou
Ji
J
Men
Xiao-Wei
XW
Zheng
Xin-Min
XM
Hu
Li-Quan
LQ
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004822:Epididymis / Q000378:metabolism*; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000378:metabolism*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014646:Varicocele / Q000378:metabolism*
D000975:Antioxidants; D019158:N-Acetylneuraminic Acid; D018817:N-Methyl-3,4-methylenedioxyamphetamine