Language and motor FMRI activation in polymicrogyric cortex.
OBJECTIVE
To analyze the patterns of brain activation in polymicrogyric cortex in epilepsy patients by blood oxygenation level-dependent (BOLD) functional MRI (fMRI), during language and motor activation tasks.


METHODS
Five patients with extratemporal epilepsy associated with polymicrogyria were scanned in a 1.5-T Siemens scanner with BOLD fMRI sequences, by following language and motor paradigms. Functional images were processed by using Brain Voyager software.


RESULTS
Activation of polymicrogyric cortex in the brain area that corresponds to the motor strip was present in all patients. Language studies revealed activation of polymicrogyric cortex over Broca's area in three cases.


CONCLUSIONS
Functionality was shown in polymicrogyric areas. Therefore if surgical resection is indicated, a careful functional planning is necessary because of functionality of the polymicrogyric cortex.
Araujo
David
D
Department of Neurology-FMRP, University of Sao Paulo, Ribeirao Preto, Brazil.
de Araujo
Draulio B
DB
Pontes-Neto
Octavio M
OM
Escorsi-Rosset
Sara
S
Simao
Gustavo N
GN
Wichert-Ana
Lauro
L
Velasco
Tonicarlo R
TR
Sakamoto
Americo C
AC
Leite
Joao P
JP
Santos
Antonio C
AC
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology* / Q000601:surgery; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D007804:Language Development; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000503:physiopathology; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010347:Patient Care Planning; D011300:Preoperative Care; D011597:Psychomotor Performance / Q000502:physiology*; D012189:Retrospective Studies; D013850:Thinking / Q000502:physiology
D010100:Oxygen