title: The making of "The Genoma Music.".
abstract: Both genetic and musical sequences are ordered structures composed of combinations of a small number of elements, of nucleotides and musical notes. In the case of the genome, the emergence of cellular functions makes the order meaningful; in the case of musical sequences, the consequence of order is the production of mysterious esthetical effects in the human mind. Can any musical significance be found in DNA sequence? In this work, we present the technique used to convert DNA sequences into musical sequences. The musical equivalent of the sequence of a number of genes, either of fungal origin, such as Candida albicans or Sacharomyces cerevisiae (SLT2), or belonging to the human genome (genes involved in Alzheimer syndrome, blindness, and deafness such as Connexine 26 gene) has been obtained. Non-coding sequences are also important in life and music. The non-coding alphoid sequence has also been translated into a musical sequence, in this case using Fibonacci golden number basic series as structural helper. The elementary musical sequence derived from DNA sequence has served as an imposing frame in which rhythms, sounds, and melodies have been harmonically inserted. The Genoma Music Project is essentially a creative metaphor of the basic unity between the human mind and the natural ordered structure of life.
authors.affiliation: Unidad de Micología, Servicio de Microbiología, Hospital Ramón y Cajal, Carretera de Colmenar Km 9,100, 28034 Madrid, Spain. asanchezsousa.hrc@salud.madrid.org
authors.forename: Aurora
authors.initials: A
authors.lastname: Sánchez Sousa
authors.forename: Fernando
authors.initials: F
authors.lastname: Baquero
authors.forename: César
authors.initials: C
authors.lastname: Nombela
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D001483:Base Sequence; D002176:Candida albicans / Q000235:genetics; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics; D005796:Genes; D005800:Genes, Fungal; D005813:Genes, Synthetic; D005815:Genetic Code; D016678:Genome; D016681:Genome, Fungal; D006801:Humans; D019369:Life; D008565:Membrane Proteins / Q000235:genetics; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics; D008969:Molecular Sequence Data; D009146:Music; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D016564:Amyloid beta-Protein Precursor; D017630:Connexins; C418975:ELOVL4 protein, human; D005136:Eye Proteins; D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins; D000072259:Connexin 26; D020928:Mitogen-Activated Protein Kinases; C072724:SLT2 protein, S cerevisiae