Adenoviral disease in pediatric solid organ transplant recipients.
Adenoviral disease in pediatric SOT recipients is emerging as an important viral pathogen, with serious consequences impacting morbidity, mortality and graft survival. The optimal diagnostic techniques, as well as therapy have yet to be established. This article reviews the current epidemiology of AdV in orthotopic liver, intestinal, cardiothoracic and renal transplant recipients. Issues related to diagnosis, notably the use of newer non-culture based viral detection methods and therapy, including anti-adenoviral agents and adoptive immunotherapy are discussed.
Hoffman
Jill A
JA
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. jhoffman@chla.usc.edu
D000256:Adenoviridae / Q000235:genetics; D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods; D015994:Incidence; D016377:Organ Transplantation; D016133:Polymerase Chain Reaction
D004279:DNA, Viral