title: [Acute leukaemia in two multiple sclerosis patients treated with mitoxantrone].
abstract: BACKGROUND
  Mitoxantrone (Mx) is used as a second-line treatment in multiple sclerosis. Since 1998, eight cases of acute leukemia (AL) have been described. We report two new cases of myeloid AL that occurred during treatment with Mx.
  
  
  METHODS
  The first case concerned a women who was treated with Mx for 3 months. In spite of a very low total dose (58.32 mg), she developed promyelocytic AL. The second patient died of myeloid AL, 27 months after the last injection of Mx.
  
  
  CONCLUSIONS
  All the reported cases of AL occurring after Mx respond to the criteria of leukemia induced by anti-topoisomerases II. Epidemiological data and those from animal experiments suggest that Mx has direct role in the occurrence of leukemia.
  
  
  CONCLUSIONS
  It must be remembered that even if the risk of Mx-induced leukemia is low, blood cell counts must be closely monitored for at least five years after the last injection of this treatment.
authors.affiliation: Service de Neurologie, Hôpital Jean Minjoz, Besançon. nolletsylvain@yahoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Nollet
authors.forename: E
authors.initials: E
authors.lastname: Berger
authors.forename: E
authors.initials: E
authors.lastname: Deconinck
authors.forename: E
authors.initials: E
authors.lastname: Baldauf
authors.forename: L
authors.initials: L
authors.lastname: Rumbach
mesh_terms: D000208:Acute Disease; D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D001772:Blood Cell Count; D005260:Female; D006801:Humans; D007938:Leukemia / Q000209:etiology*; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000700:Analgesics; D008942:Mitoxantrone