title: A possible mechanism for phenol-induced pemphigus.
abstract: A possible mechanism for phenol-induced pemphigus lesions in genetically predisposed individuals is proposed that accounts for in vitro observations and cases of biochemical acantholysis, as well as the in vivo acantholysis in pemphigus induced by phenols. The mechanism involves the induction of interleukin-1a and tumor necrosis factor-a release by keratinocytes. These cytokines in turn have been shown to be involved in the regulation and synthesis of complement and proteases like plasminogen activator, which have been implicated in the pathogenesis of acantholysis in pemphigus vulgaris.
authors.affiliation: Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. derma@tasmc.health.gov.il
authors.forename: Sarah
authors.initials: S
authors.lastname: Brenner
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ruocco
authors.forename: Eleonora
authors.initials: E
authors.lastname: Ruocco
authors.forename: Avigdor
authors.initials: A
authors.lastname: Srebrnik
authors.forename: Ilan
authors.initials: I
authors.lastname: Goldberg
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D010392:Pemphigus / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D010636:Phenols / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D010636:Phenols