Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.
BACKGROUND
There are few biological markers, which strictly show the severity of congestive heart failure (CHF).


RESULTS
Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05).


CONCLUSIONS
The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.
Oyama
Naotsugu
N
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Urasawa
Kazushi
K
Kaneta
Satoshi
S
Sakai
Hidetsugu
H
Saito
Takahiko
T
Takagi
Chika
C
Yoshida
Ichiro
I
Kitabatake
Akira
A
Tsutsui
Hiroyuki
H
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D005260:Female; D051606:G-Protein-Coupled Receptor Kinase 1 / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D006333:Heart Failure / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012720:Severity of Illness Index
D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D012333:RNA, Messenger; D011943:Receptors, Adrenergic, beta; D051606:G-Protein-Coupled Receptor Kinase 1