Expression of FGFRL1, a novel fibroblast growth factor receptor, during embryonic development.
FGFRL1 is a novel member of the fibroblast growth factor receptor (FGFR) family. To investigate its expression during mammalian embryonic development, we have used the mouse system. Expression of Fgfrl1 is very low in mouse embryos of day 6 but steadily increases until birth. As demonstrated by in situ hybridization of 16-day-old embryos, the Fgfrl1 mRNA occurs in cartilaginous structures such as the primordia of bones and the permanent cartilage of the trachea, the ribs and the nose. In addition, some muscle types, including the muscles of the tongue and the diaphragm, express Fgfrl1 at relatively high level. In contrast, the heart and the skeletal muscles of the limbs, as well as many other organs (brain, lung, liver, kidney, gut) express Fgfrl1 only at basal level. It is conceivable that Fgfrl1 interacts with other Fgfrs, which are expressed in cartilage and muscle, to modulate FGF signaling.
Trueb
Beat
B
ITI Research Institute, University of Bern, CH-3010 Bern, Switzerland. beat.trueb@iti.unibe.ch
Taeschler
Sara
S
D000818:Animals; D015152:Blotting, Northern; D004622:Embryo, Mammalian / Q000378:metabolism*; D047108:Embryonic Development / Q000235:genetics; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051500:Receptor, Fibroblast Growth Factor, Type 5 / Q000235:genetics*; D013997:Time Factors
C496379:Fgfrl1 protein, mouse; D012333:RNA, Messenger; D051500:Receptor, Fibroblast Growth Factor, Type 5