Determination of Cefdinir by a stability-indicating liquid chromatographic method.
A simple, fast, specific, stability-indicating, and precise reversed-phase liquid chromatographic method was developed for the determination of Cefdinir in its different dosage forms, i.e., capsules and suspensions. The method was developed and optimized by analyzing the placebo preparation, formulations, and degraded samples of the drug substance according to the International Conference on Harmonization. The proposed method can successfully separate the drug from degradation products formed under stress conditions along with pharmaceutical ingredients such as preservatives. The developed method was used successfully to determine Cefdinir in capsules and Insta-use suspensions. The developed method was found to be linear for a concentration range of 6-14 microg/mL. Average recoveries obtained with the method were 99.3 +/- 0.4 and 99.6 +/- 0.4% for Insta-use suspensions and capsules, respectively. The method was shown to be specific, precise, and robust.
Mehta
Tushar N
TN
Shri S.K. Patel College of Pharmaceutical Education and Research, Ganpat Vidhyanagar, Kherva, Mehsana District, PIN Code 382711, India.
Subbaiah
Gunta
G
Pundarikakshudu
Kilambi
K
D000890:Anti-Infective Agents / Q000737:chemistry*; D002214:Capsules; D000077525:Cefdinir; D002511:Cephalosporins / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002845:Chromatography; D002853:Chromatography, Liquid / Q000379:methods*; D004355:Drug Stability; D008956:Models, Chemical; D004364:Pharmaceutical Preparations; D010919:Placebos; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000890:Anti-Infective Agents; D002214:Capsules; D002511:Cephalosporins; D004364:Pharmaceutical Preparations; D010919:Placebos; D000077525:Cefdinir