Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.
Cardona
Kenneth
K
Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, Georgia 30322, USA.
Korbutt
Gregory S
GS
Milas
Zvonimir
Z
Lyon
James
J
Cano
Jose
J
Jiang
Wanhong
W
Bello-Laborn
Hameeda
H
Hacquoil
Brad
B
Strobert
Elizabeth
E
Gangappa
Shivaprakash
S
Weber
Collin J
CJ
Pearson
Thomas C
TC
Rajotte
Ray V
RV
Larsen
Christian P
CP
D000818:Animals; D000831:Animals, Newborn; D064987:Cell- and Tissue-Based Therapy; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D007515:Islets of Langerhans / Q000166:cytology / Q000276:immunology; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D008251:Macaca / Q000276:immunology*; D010180:Pancreatectomy; D013552:Swine / Q000276:immunology; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000276:immunology