[The influence of the 1-(2'-hydroxiethyl)-2-methyl-5-nitroimidazole on the state of erythrocyte membranes and their models].
Metronidazolum decreased diffusion mobility of membrane surface water. It is possible, that Wuks's effect represents the molecular mechanism underlying this phenomenon. We suppose, that protective action of the derivatives of the nitroimidazole on cell lysis is related to changes of the diffusion mobility of the surface water.
Kuznetsov
P E
PE
Popykhova
E B
EB
Rogacheva
S M
SM
Evlakov
K I
KI
D000818:Animals; D000981:Antiprotozoal Agents / Q000378:metabolism* / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004058:Diffusion; D004910:Erythrocyte Membrane / Q000378:metabolism*; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D051381:Rats; D014867:Water / Q000378:metabolism*
D000981:Antiprotozoal Agents; D014867:Water; D008795:Metronidazole