title: Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma.
abstract: We investigated the relationship between inflammatory and anti-inflammatory cytokines in the pathogenesis of chronic subdural hematoma (CSDH) by measuring the plasma and subdural fluid levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). The levels of IL-6, IL-8 and IL-10 were measured in the subdural fluid obtained from 34 patients with CSDH, using the enzyme-linked immunosorbent assay. The patients were classified into a high IL-10 group and a low IL-10 group according to the level of IL-10 in their subdural fluid samples. The subdural fluid levels of IL-6 and IL-8 were significantly higher in the high IL-10 group than in the low IL-10 group (P<0.05). A tendency for the patients in the low IL-10 group to show the separated or layer type of pattern on the CT scans was noted.
authors.affiliation: Department of Emergency Medicine, Iwate Medical University, Uchimaru 19-1, Morioka, 020-8505, Japan. twada@iwate-med.ac.jp
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Wada
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kuroda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Akira
authors.initials: A
authors.lastname: Ogawa
authors.forename: Shigeatsu
authors.initials: S
authors.lastname: Endo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D002097:C-Reactive Protein; D018450:Disease Progression; D005260:Female; D020200:Hematoma, Subdural, Chronic / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D002097:C-Reactive Protein