Mammalian cell-derived somatropin : a review of its use in the management of HIV-associated wasting.
HIV-associated wasting, characterised by progressive loss of lean body mass and bodyweight, remains a significant problem in the era of highly active antiretroviral therapy (HAART). Loss of body cell mass, a component of lean body mass, is associated with decreased survival. Somatropin (recombinant human growth hormone) derived from mammalian cells (Serostim) is the only US FDA-approved treatment indicated to increase lean body mass, bodyweight and physical endurance in HIV-associated wasting. Somatropin 0.1 mg/kg/day administered subcutaneously for 12 weeks effectively increased work output, bodyweight and lean body mass and improved health-related quality of life (HR-QOL), compared with placebo, and had a generally manageable tolerability profile in a large randomised study in patients with HIV-associated wasting. Potential areas for further research include determination of longer-term efficacy and tolerability, the cost effectiveness of treatment, the optimal somatropin dosage, management of patients after 12 weeks' therapy and whether maintenance strategies might exist to maintain accrued lean body mass with lower doses of somatropin. Nevertheless, indications to date are that somatropin is likely to have an important role in the treatment of patients with HIV-associated wasting.
Goldsmith
David R
DR
Adis International Limited, Auckland, New Zealand. demail@adis.co.nz
Wagstaff
Antona J
AJ
D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004334:Drug Administration Schedule; D004734:Energy Metabolism / Q000187:drug effects; D013006:Growth Hormone / Q000008:administration & dosage / Q000235:genetics / Q000627:therapeutic use*; D019247:HIV Wasting Syndrome / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007279:Injections, Subcutaneous; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
D011994:Recombinant Proteins; D013006:Growth Hormone