title: Molecular neurobiological methods in marijuana-cannabinoid research.
abstract: Recent aggregation of evidence for the roles of endogenous agonist and receptor systems that are mimicked or activated by cannabanoid ligands has provided a focus for work that has elucidated details of some of the multiple physiological roles and pharmacological functions that these systems play in brain and peripheral tissues. This chapter reviews some of the approaches to improved elucidation of these systems, with special focus on the human genes that encode cannabanoid receptors and the variants in these receptors that appear likely to contribute to human addiction vulnerabilities.
authors.affiliation: Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Uhl
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ishiguro
authors.forename: Emmanuel S
authors.initials: ES
authors.lastname: Onaivi
authors.forename: Ping-Wu
authors.initials: PW
authors.lastname: Zhang
authors.forename: B Emmanuel
authors.initials: BE
authors.lastname: Akinshola
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Lin
authors.forename: Bruce
authors.initials: B
authors.lastname: Hope
authors.forename: Claire M
authors.initials: CM
authors.lastname: Leonard
authors.forename: Qing-Rong
authors.initials: QR
authors.lastname: Liu
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D016466:CHO Cells; D019556:COS Cells; D002186:Cannabinoids / Q000494:pharmacology*; D002188:Cannabis; D002522:Chlorocebus aethiops; D006224:Cricetinae; D015894:Genome, Human; D006801:Humans; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000187:drug effects / Q000378:metabolism; D043885:Receptor, Cannabinoid, CB2 / Q000187:drug effects / Q000378:metabolism; D014982:Xenopus laevis
chemical_list: D002186:Cannabinoids; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2