title: The mechanisms and functions of activity-dependent long-term potentiation of intrinsic excitability.
abstract: The efficiency of neural circuits can be enhanced not only by increasing synaptic strength but also by increasing neuronal intrinsic excitability. Three major types of activity-dependent long-term potentiation of intrinsic excitability (LTP-IE) have been well defined: decreased action potential (AP) threshold, reduced afterhyperpolarization (AHP), and attenuated dendritic propagation. The ionic basis and induction pathways for these three types of LTP-IE have been largely revealed recently. These intrinsic plasticities and their cooperation enrich the functions fulfilled by neurons, and may serve as a supplementary mechanism for learning and memory.
authors.affiliation: Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D007473:Ion Channels / Q000378:metabolism; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D007473:Ion Channels