Transoesophageal cardiac pacing is effective for cardiopulmonary resuscitation in a rat of asphyxial model.
OBJECTIVE
To investigate effectiveness of transoesophageal cardiac pacing in a rat model of asphyxial cardiac arrest.


METHODS
Ten minutes after the tracheal tube had been clamped, cardiac arrest (CA) occurred in 20 Sprague-Dawley rats, and the rats were assigned randomly to receive cardiopulmonary resuscitation (CPR) in a control group or CPR combined with transoesophageal cardiac pacing in a pacing group. Restoration of spontaneous circulation (ROSC) was defined as an unassisted pulse with a mean arterial pressure (MAP) of >or=20 mmHg for >or=1 min.


RESULTS
ROSC was significantly more frequent in the pacing group compared with the control group (7/10 versus 1/10, P<0.05). Faster ROSC and longer survival trend in the pacing group were seen compared with the control group.


CONCLUSIONS
Transoesophageal cardiac pacing is effective for CPR in a rat of asphyxial model. However, the precise mechanism is not clear and further experiments will be necessary.
Song
Feng-Qing
FQ
Institute of Cardiovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, PR China.
Xie
Lu
L
Chen
Meng-Hua
MH
D000818:Animals; D001237:Asphyxia; D001794:Blood Pressure; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D016887:Cardiopulmonary Resuscitation; D004195:Disease Models, Animal; D005260:Female; D006323:Heart Arrest / Q000628:therapy*; D008297:Male; D011674:Pulse; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors