title: Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults).
abstract: OBJECTIVE
  To clarify the clinical significance of subclinical rhythmic EEG discharge of adults' (SREDA) by analyzing characteristics of SREDA and the outcome of patients based on retrospective analysis of EEG data base.
  
  
  METHODS
  EEGs were recorded soon after the onset of patient's initial symptoms and repeatedly recorded at various intervals of 2-3 months in all 4 patients. Neurological findings, MRI and SPECT were also investigated.
  
  
  METHODS
  Out of 340 consecutive inpatient population who had EEGs, 4 patients (1.2%) showed SREDA. They had a diagnosis of syncope, transient global amnesia, generalized tonic-clonic seizure and right temporal lobe epilepsy for each.
  
  
  RESULTS
  There was no consistent abnormality in the brain MRI, CT or SPECT among the 4 patients. The acute and transient symptoms disappeared and did not recur within the follow-up period of 28 months in any patient. In 2 patients SREDA disappeared in the follow-up EEG taken 7-14 days after the first EEG showing SREDA. In the other 2 patients, the follow-up EEGs taken 5 days after the first EEG with SREDA when clinical symptoms disappeared showed less frequent occurrence of SREDA.
  
  
  CONCLUSIONS
  Being different from the previous reports suggesting the relation with cardiogenic insults or persistent ischemic abnormality, SREDA can occur in patients with various acute brain dysfunctions followed by a favorable clinical outcome.
authors.affiliation: Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto.
authors.forename: Tahamina
authors.initials: T
authors.lastname: Begum
authors.forename: Akio
authors.initials: A
authors.lastname: Ikeda
authors.forename: Jun
authors.initials: J
authors.lastname: Takahashi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tomimoto
authors.forename: Shun
authors.initials: S
authors.lastname: Shimohama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Satow
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagamine
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibasaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000503:physiopathology; D001927:Brain Diseases / Q000175:diagnosis / Q000503:physiopathology*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013575:Syncope / Q000503:physiopathology