title: [Effects of Yiqi Huayu Recipe on neural cell adhesion molecule in rats with lumbar nerve root compression].
abstract: OBJECTIVE
  To study the effects of Yiqi Huayu Recipe on neural cell adhesion molecule (N-CAM) in neuromuscular junctions during nerve regeneration in rats with lumbar nerve root compression.
  
  
  METHODS
  The rats with lumbar nerve root compression were given Yiqi Huayu Recipe for 10, 20 and 30 days respectively. The distribution of N-CAM in neuromuscular junctions of soleus muscle in rats was examined with immunohistochemical method and confocal laser scanning microscopy technique. The acetylcholine receptor (AChR) was visualized with fluorescein-conjugated alpha-bungarotoxin (alpha-BTX). The overlap areas of N-CAM and AChR sites were measured with NIH image technique.
  
  
  RESULTS
  The aggregates, sprouts and extensions of N-CAM in the neuromuscular junctions and the overlap areas of N-CAM and AChR sites in the Yiqi Huayu Recipe-treated group were all better improved than those in the untreated group.
  
  
  CONCLUSIONS
  The expression of N-CAM is regulated according to the state of innervation for muscles. Yiqi Huayu Recipe may accelerate this nerve regeneration process.
authors.affiliation: Institute of Spinal Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. zhouchongjian011@163.com
authors.forename: Chong-Jian
authors.initials: CJ
authors.lastname: Zhou
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Ma
authors.forename: Bing
authors.initials: B
authors.lastname: Shu
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009408:Nerve Compression Syndromes / Q000378:metabolism*; D009416:Nerve Regeneration; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis* / Q000235:genetics; D009469:Neuromuscular Junction / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011950:Receptors, Cholinergic / Q000378:metabolism; D013126:Spinal Nerve Roots
chemical_list: D004365:Drugs, Chinese Herbal; D019006:Neural Cell Adhesion Molecules; D011950:Receptors, Cholinergic