[Diagnostic significance of urine chemiluminescence in patients with nonspecific pulmonary diseases].
OBJECTIVE
To evaluate functional activity of the kidneys in patients with nonspecific pulmonary diseases (NSPD).


METHODS
Routine renal function tests, registration of iron-induced urine chemiluminescence (CL), estimation of middle-molecular oligopeptides in blood serum and urine were made in 22 patients with pneumonia, 18 patients with chronic non-obstructive bronchitis and 16 ones with chronic obstructive pulmonary disease.


RESULTS
Urine CL was subnormal in all the patients. This CL intensity correlated with functional renal characteristics, negatively correlated with endotoxicosis severity. In a favourable course of the disease, CL intensity increased, renal function and content of middle-molecular oligopeptides in biological substrates normalized. In patients with lingering and chronic inflammation CL remained low, renal dysfunction and endotoxicosis persisted.


CONCLUSIONS
Registration of iron-induced urine CL can be used for control over NSPD patients condition and efficacy of their treatment.
Farkhutdinov
U R
UR
D000328:Adult; D015415:Biomarkers / Q000652:urine; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D008171:Lung Diseases / Q000175:diagnosis / Q000652:urine*; D008875:Middle Aged; D009842:Oligopeptides / Q000652:urine*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D016482:Urinalysis / Q000379:methods; D014556:Urine / Q000737:chemistry*
D015415:Biomarkers; D009842:Oligopeptides