title: Optimal reactive vaccination strategies for a foot-and-mouth outbreak in the UK.
abstract: Foot-and-mouth disease (FMD) in the UK provides an ideal opportunity to explore optimal control measures for an infectious disease. The presence of fine-scale spatio-temporal data for the 2001 epidemic has allowed the development of epidemiological models that are more accurate than those generally created for other epidemics and provide the opportunity to explore a variety of alternative control measures. Vaccination was not used during the 2001 epidemic; however, the recent DEFRA (Department for Environment Food and Rural Affairs) contingency plan details how reactive vaccination would be considered in future. Here, using the data from the 2001 epidemic, we consider the optimal deployment of limited vaccination capacity in a complex heterogeneous environment. We use a model of FMD spread to investigate the optimal deployment of reactive ring vaccination of cattle constrained by logistical resources. The predicted optimal ring size is highly dependent upon logistical constraints but is more robust to epidemiological parameters. Other ways of targeting reactive vaccination can significantly reduce the epidemic size; in particular, ignoring the order in which infections are reported and vaccinating those farms closest to any previously reported case can substantially reduce the epidemic. This strategy has the advantage that it rapidly targets new foci of infection and that determining an optimal ring size is unnecessary.
authors.affiliation: Department of Biological Sciences and Mathematics Institute, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Tildesley
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Savill
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Shaw
authors.forename: Rob
authors.initials: R
authors.lastname: Deardon
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Brooks
authors.forename: Mark E J
authors.initials: ME
authors.lastname: Woolhouse
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Grenfell
authors.forename: Matt J
authors.initials: MJ
authors.lastname: Keeling
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000276:immunology / Q000821:virology; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D004196:Disease Outbreaks / Q000517:prevention & control* / Q000662:veterinary*; D005536:Foot-and-Mouth Disease / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D008954:Models, Biological; D006113:United Kingdom / Q000453:epidemiology; D014611:Vaccination / Q000379:methods*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D014765:Viral Vaccines