The role of Toll-like receptors in immune disorders.
Toll-like receptors (TLRs) play an important role in innate immunity. Individual TLRs recognise microbial components that are conserved among pathogens. Such recognition initiates necessary inflammatory immune responses and induces subsequent activation of adaptive immunity. Studies in people with polymorphisms in genes encoding TLR signalling can elucidate the relationship between TLRs and human diseases, such as infectious diseases, atherosclerosis and immunodeficiency. Indeed, accumulating data in respect to TLR signalling suggest that TLRs are closely related with the pathogenesis of autoimmune diseases. This review looks at the role of TLRs in various immune disorders, and discusses the pathogenesis of diseases.
Uematsu
Satoshi
S
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565-0851, Japan.
Akira
Shizuo
S
D000818:Animals; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate / Q000187:drug effects / Q000235:genetics; D007378:Interleukins / Q000008:administration & dosage; D011110:Polymorphism, Genetic / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D051193:Toll-Like Receptors / Q000819:agonists / Q000502:physiology*
D007378:Interleukins; D051193:Toll-Like Receptors