title: Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study.
abstract: Study on the normal saline vs povidone-iodine mouthwashes for oral mucositis (OM) prophylaxis in patients after high-dose chemotherapy comprising bischloroethyl nitrosourea etoposide ara-C melphalan (BEAM) or high-dose melphalan (HD-L-PAM) followed by autologous peripheral stem cell transplantation indicated that females have higher a incidence of OM compared to men, as reported by [Vokurka et al. 13:554-558, (2005)]. The multivariable analysis of larger cohort of 148 patients compliant with the original study protocol confirmed female gender to be an independent risk factor and predictor for OM. The HD-L-PAM (200 mg/m2) conditioning regimen revealed to be more toxic compared to BEAM as for incidence of OM grades 3-4 World Health Organization score. Body mass index, age, mouthwash solution used, and CD34+ cell number in the autologous graft were verified not to have an impact on OM incidence in this group of patients.
authors.affiliation: Department of Haemato-Oncology, University Hospital, Alej Svobody 80, Plzen, 304 60, Czech Republic. vokurka@fnplzen.cz
authors.forename: Samuel
authors.initials: S
authors.lastname: Vokurka
authors.forename: Eva
authors.initials: E
authors.lastname: Bystrická
authors.forename: Vladimír
authors.initials: V
authors.lastname: Koza
authors.forename: Jana
authors.initials: J
authors.lastname: Scudlová
authors.forename: Vladislava
authors.initials: V
authors.lastname: Pavlicová
authors.forename: Dana
authors.initials: D
authors.lastname: Valentová
authors.forename: Maria
authors.initials: M
authors.lastname: Visokaiová
authors.forename: Lubica
authors.initials: L
authors.lastname: Misaniová
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002330:Carmustine / Q000008:administration & dosage / Q000009:adverse effects; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D019226:Oral Ulcer / Q000139:chemically induced / Q000453:epidemiology; D036102:Peripheral Blood Stem Cell Transplantation; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013280:Stomatitis / Q000139:chemically induced* / Q000453:epidemiology*; D014182:Transplantation, Autologous
chemical_list: D003561:Cytarabine; D005047:Etoposide; D008558:Melphalan; D002330:Carmustine