[Abnormalities in stomach and duodenal ulcer immunoregulation].
The effect of the immunity state on the clinical course of stomach ulcer was studied. The study involved 50 patients (38 men and 12 women being 17-67 years old) with stomach ulcer (n = 14) and duodenal ulcer (n = 36) in the acute condition and 25 healthy blood donors. Twenty-seven patients underwent an immunology study. It was revealed that the evident increase of circulatory lymphocyte apoptosis (> 10), which is associated with the depression of their proliferative activity in vitro culture, is recorded with 40.7% of patients (11/27). It was also revealed that a high level of circulatory lymphocyte apoptosis and apoptosis-associated dysfunctions are found more frequently in people with long-term and complicated clinical course.
Paltsev
A I
AI
Chernykh
E R
ER
Lebedev
A G
AG
D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis; D049109:Cell Proliferation; D004381:Duodenal Ulcer / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000276:immunology*