title: Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis).
abstract: An investigation of the polar glycosidic fraction from the leaves of myrtle afforded four galloylated nonprenylated phloroglucinol glucosides (3a-d) related to the endoperoxide hormone G3 (4) in terms of structure and biogenesis. Despite their close similarity, significant antibacterial activity was shown only by one of these compounds (3b, gallomyrtucommulone B), while the G3 hormone (4) was inactive.
authors.affiliation: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy. appendino@pharm.unipmn.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Lucia
authors.initials: L
authors.lastname: Maxia
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Bettoni
authors.forename: Monica
authors.initials: M
authors.lastname: Locatelli
authors.forename: Carola
authors.initials: C
authors.lastname: Valdivia
authors.forename: Mauro
authors.initials: M
authors.lastname: Ballero
authors.forename: Michael
authors.initials: M
authors.lastname: Stavri
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000900:Anti-Bacterial Agents; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D031651:Myrtus / Q000737:chemistry*; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005960:Glucosides; D010696:Phloroglucinol