title: A neuropeptide in immune-mediated inflammation, Y?
abstract: Disturbances in crosstalk between the immune system and the sympathetic nervous system (SNS) can contribute to the pathogenesis of Th1-mediated autoimmunity. Recent studies indicate that neuropeptide Y (NPY) has a major role in the regulation of Th1 responses. The precise role of NPY has been an enigma, but a recent study provides a breakthrough, demonstrating that NPY has a bimodal role as a negative regulator of T cells and an activator of antigen-presenting cell function.
authors.affiliation: Department of Neurology, and Program in Immunology, University of California, San Francisco, San Francisco, CA 94143-0114, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Prod'homme
authors.forename: Martin S
authors.initials: MS
authors.lastname: Weber
authors.forename: Lawrence
authors.initials: L
authors.lastname: Steinman
authors.forename: Scott S
authors.initials: SS
authors.lastname: Zamvil
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D009474:Neurons / Q000276:immunology / Q000378:metabolism; D009478:Neuropeptide Y / Q000172:deficiency / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y