title: [Is pure red cell aplasia a new extra digestive manifestation of celiac disease?].
abstract: BACKGROUND
  Celiac disease is an autoimmune enteropathy that appears on a predisposed genetic background. Its clinical presentation has been extended those last years by varied extradigestive manifestations.
  
  
  METHODS
  This is a case report of a twenty-year-old woman who presented simultaneously a celiac disease and pure red cell aplasia. The IgA and IgG antigliadin antibodies as well as antinuclear, anti-DNA, anti-SSA and anti-SSB antibodies were detected, without any clinical symptom supporting the diagnosis of systemic lupus erythematosus or Sjögren syndrome. Thoracic CT-scan reveals a thymus enlargement and biopsy concludes to thymus hyperplasia at histological examination. Pure red cell aplasia regressed after gluten-free diet, corticoid therapy and thymectomy.
  
  
  CONCLUSIONS
  This observation, added to the three others paediatric cases previously published in the literature concern an uncommon association between pure red cell aplasia and celiac disease. However, they are not enough to conclude to a direct link between these two disorders. Pure red cell aplasia could represent un new dysimmune manifestation occurring in celiac disease, but this will need to be confirmed with others cases.
authors.affiliation: Service de Médecine Interne, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille (APHM), Université de la Méditerranée, chemin des Bourrely, 13915 Marseille, cedex 20, France.
authors.forename: A-L
authors.initials: AL
authors.lastname: Couderc
authors.forename: R
authors.initials: R
authors.lastname: Costello
authors.forename: D
authors.initials: D
authors.lastname: Bagnères
authors.forename: P
authors.initials: P
authors.lastname: Rossi
authors.forename: V
authors.initials: V
authors.lastname: Vitton
authors.forename: A-L
authors.initials: AL
authors.lastname: Demoux
authors.forename: S
authors.initials: S
authors.lastname: Bonin-Guillaume
authors.forename: Y
authors.initials: Y
authors.lastname: Francès
authors.forename: B
authors.initials: B
authors.lastname: Granel
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000178:diet therapy / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D013902:Radiography, Thoracic; D012010:Red-Cell Aplasia, Pure / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D013934:Thymectomy; D013950:Thymus Gland / Q000473:pathology; D013952:Thymus Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones