title: New route to the synthesis of bis[N-(2-aminoethyl) salicylaldiminato] chromium(III) chloride monohydrate Spectroscopic characterization, crystal structure and interaction with DNA.
abstract: The reaction of [Cr(urea)(6)]Cl(3).3H(2)O with H(2)salen (H(2)salen=N,N(')-ethylenebis(salicylaldimine) in water-methanol mixture (40:60v/v) under reflux yielded the complex bis[N-(2-aminoethyl)salicylaldiminato]chromium(III) chloride monohydrate, [Cr(aesaldmn)(2)]Cl.H(2)O. The complex was characterized by elemental analysis, molar conductance, magnetic susceptibility, spectroscopic (UV-vis and IR) data and X-ray diffraction studies. The new ligand, N-(2-aminoethyl)salicylaldimine, Haesaldmn, possibly resulted from the hydrolytic cleavage of one end of the H(2)salen ligand during reflux. Binding of this chromium(III) complex to CT DNA has been studied using UV-vis spectroscopy with an apparent binding constant of 2.68 x 10(3)M(-1). It shows that the binding mode is electrostatic while the emission of ethidium bromide to CT DNA in the absence and in the presence of the complex show that it binds DNA with partial intercalation.
authors.affiliation: Department of Chemistry, University of Kalyani, Kalyani 741235, India.
authors.forename: Susobhan
authors.initials: S
authors.lastname: Biswas
authors.forename: Saikat
authors.initials: S
authors.lastname: Sarkar
authors.forename: Kamalendu
authors.initials: K
authors.lastname: Dey
authors.forename: Bimal
authors.initials: B
authors.lastname: Jana
authors.forename: Tarakdas
authors.initials: T
authors.lastname: Basu
authors.forename: Glenn P A
authors.initials: GP
authors.lastname: Yap
authors.forename: Kevin
authors.initials: K
authors.lastname: Kreisel
mesh_terms: D017608:Chromium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D003461:Crystallography; D004247:DNA / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D055672:Static Electricity; D014961:X-Ray Diffraction
chemical_list: D017608:Chromium Compounds; D009942:Organometallic Compounds; C517024:bis(N-(2-aminoethyl) salicylaldiminato) chromium(III) chloride; D004247:DNA