title: Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population.
abstract: Disrupted-in-Schizophrenia-1 (DISC1) has first been identified as a candidate gene for schizophrenia through study of a Scottish family with a balanced (1; 11) (q42.1; q14.3) translocation. Lots of linkage and association studies supported DISC1 as a risk factor for schizophrenia. In this study, we genotyped three SNPs in DISC1 using a set of Han Chinese samples of 560 schizophrenics and 576 controls. No positive association was detected in the whole samples but analysis of allele frequencies in female samples showed weak association between SNP rs2295959 and the disease (chi(2)=6.188, P=0.0135, OR=0.728, 95% CI=0.567-0.935). Our results provide further evidence for sex difference for the effect of the gene on the aetiology of schizophrenia. Our findings also would encourage further studies, particularly family-based association studies with larger samples, to analyze the association between DISC1 and schizophrenia.
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China.
authors.forename: Qing-Ying
authors.initials: QY
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Guo-Yin
authors.initials: GY
authors.lastname: Feng
authors.forename: Klaus
authors.initials: K
authors.lastname: Lindpaintner
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.forename: Zheng-Xiong
authors.initials: ZX
authors.lastname: Chen
authors.forename: Zhen-Song
authors.initials: ZS
authors.lastname: Gao
authors.forename: Ji-Sheng
authors.initials: JS
authors.lastname: Tang
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C412476:DISC1 protein, human; D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D008666:Metalloendopeptidases; C057543:oligopeptidase A