High frequency of iatrogenic monozygotic twins with administration of clomiphene citrate and a change in chorionicity.
The data of the population-based, prospective survey of multiple births in East Flanders, Belgium, show that a greater proportion of monozygotic twins is observed with clomiphene citrate as sole treatment compared with other ovulatory drugs. Among iatrogenic monozygotic twins, the ratio of monochorionic versus dichorionic pairs is higher compared with spontaneous twins.
Derom
Catherine
C
Center of Human Genetics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium. catherine.derom@uz.kuleuven.ac.be
Leroy
Fernand
F
Vlietinck
Robert
R
Fryns
Jean-Pierre
JP
Derom
Robert
R
D002823:Chorion; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006062:Gonadotropins / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted; D014310:Triplets; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D005300:Fertility Agents, Female; D006062:Gonadotropins; D002996:Clomiphene