title: Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial.
abstract: BACKGROUND
  Intracoronary transfer of autologous bone marrow cells (BMCs) may enhance recovery of left ventricular (LV) function in patients after acute myocardial infarction (AMI). However, clinical studies addressing the effects of BMCs after AMI have covered only limited time frames ranging from 3 to 6 months. The critical question of whether BMC transfer can have a sustained impact on LV function remains unanswered.
  
  
  RESULTS
  After percutaneous coronary intervention with stent implantation (PCI) of the infarct-related artery, 60 patients were randomized 1:1 to a control group with optimal postinfarction therapy and a BMC transfer group that also received an intracoronary BMC infusion 4.8+/-1.3 days after PCI. Cardiac MRI was performed 3.5+/-1.5 days, 6+/-1 months, and 18+/-6 months after PCI. BMC transfer was not associated with adverse clinical events. In the control group, mean global LV ejection fraction increased by 0.7 and 3.1 percentage points after 6 and 18 months, respectively. LV ejection fraction in the BMC transfer group increased by 6.7 and 5.9 percentage points. The difference in LVEF improvement between groups was significant after 6 months but not after 18 months (P=0.27). The speed of LV ejection fraction recovery over the course of 18 months was significantly higher in the BMC transfer group (P=0.001).
  
  
  CONCLUSIONS
  In this study, a single dose of intracoronary BMCs did not provide long-term benefit on LV systolic function after AMI compared with a randomized control group; however, the study suggests an acceleration of LV ejection fraction recovery after AMI by BMC therapy.
authors.affiliation: Department of Cardiology, Hannover Medical School, Hannover, Germany.
authors.forename: Gerd P
authors.initials: GP
authors.lastname: Meyer
authors.forename: Kai C
authors.initials: KC
authors.lastname: Wollert
authors.forename: Joachim
authors.initials: J
authors.lastname: Lotz
authors.forename: Jan
authors.initials: J
authors.lastname: Steffens
authors.forename: Peter
authors.initials: P
authors.lastname: Lippolt
authors.forename: Stephanie
authors.initials: S
authors.lastname: Fichtner
authors.forename: Hartmut
authors.initials: H
authors.lastname: Hecker
authors.forename: Arnd
authors.initials: A
authors.lastname: Schaefer
authors.forename: Lubomir
authors.initials: L
authors.lastname: Arseniev
authors.forename: Bernd
authors.initials: B
authors.lastname: Hertenstein
authors.forename: Arnold
authors.initials: A
authors.lastname: Ganser
authors.forename: Helmut
authors.initials: H
authors.lastname: Drexler
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D016026:Bone Marrow Transplantation / Q000379:methods*; D003331:Coronary Vessels; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D015607:Stents; D013318:Stroke Volume; D013599:Systole; D016896:Treatment Outcome; D016277:Ventricular Function, Left