title: Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer.
abstract: OBJECTIVE
  In light to association of increased platelet glycoprotein Ia (GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C807/T807), affecting the GPIa gene expression, in the development of oral cancer.
  
  
  METHODS
  DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis.
  
  
  RESULTS
  The mutant T807 allele homozygotes were significantly increased in the group of patients compared to the control group (P < 0.001). Furthermore, significantly increased frequency of mutant alleles compared to controls was observed in the subgroup of patients with a positive history for cancer (P < 0.01).
  
  
  CONCLUSIONS
  The obtained results indicate that the C807/T807 polymorphism is indeed a genetic predisposing factor which contributes to increased risk for oral cancer.
authors.affiliation: Department of Maxillofacial Surgery, University of Athens Medical School, Vas. Sofias 93 and Dim. Soutsou 1, Athens 11521, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Vairaktaris
authors.forename: C
authors.initials: C
authors.lastname: Yapijakis
authors.forename: S
authors.initials: S
authors.lastname: Derka
authors.forename: S
authors.initials: S
authors.lastname: Vassiliou
authors.forename: Z
authors.initials: Z
authors.lastname: Serefoglou
authors.forename: A
authors.initials: A
authors.lastname: Vylliotis
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
authors.forename: I
authors.initials: I
authors.lastname: Springer
authors.forename: E
authors.initials: E
authors.lastname: Nkenke
authors.forename: P
authors.initials: P
authors.lastname: Kessler
authors.forename: F W
authors.initials: FW
authors.lastname: Neukam
mesh_terms: D000483:Alleles; D004273:DNA, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D039421:Integrin alpha2 / Q000235:genetics* / Q000378:metabolism; D009062:Mouth Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
chemical_list: D004273:DNA, Neoplasm; D039421:Integrin alpha2