title: Severe hypophosphatemia in sepsis as a mortality predictor.
abstract: Hypophosphatemia has long been reported to be associated with sepsis and has been correlated with sepsis severity. This retrospective study was undertaken at a university hospital to determine whether severe hypophosphatemia could serve as a mortality predictor in septic patients. Charts of 6,190 septic patients who were hospitalized during one year (2001-02) were examined. Fifty-five patients were selected and were divided into 2 groups: group 1 comprised 26 patients with severe hypophosphatemia (serum inorganic phosphate (Pi) <1 mg/dl); group 2 comprised 29 patients without severe hypophosphatemia (Pi >1 mg/dl. The patients' charts were reviewed and information was collected regarding medical anamnesis, physical examination, hematological and biochemical analyses, chest x-ray, and cultures of blood and urine. The results demonstrated that 80.8% of the patients with severe hypophosphatemia died, vs 34.5% of the patients without severe hypophosphatemia (p = 0.001). Being in the severe hypophosphatemic group increased the risk of death by nearly 8-fold (odds ratio = 7.98; 95% CI = 2.3 to 27.6). These findings indicate that severe hypophosphatemia can serve as an independent mortality predictor in sepsis.
authors.affiliation: Edith Wolfson Medical Center, PO Box 5, Holon, Israel.
authors.forename: Renana
authors.initials: R
authors.lastname: Shor
authors.forename: Aaron
authors.initials: A
authors.lastname: Halabe
authors.forename: Sofia
authors.initials: S
authors.lastname: Rishver
authors.forename: Yulian
authors.initials: Y
authors.lastname: Tilis
authors.forename: Zipora
authors.initials: Z
authors.lastname: Matas
authors.forename: Asora
authors.initials: A
authors.lastname: Fux
authors.forename: Mona
authors.initials: M
authors.lastname: Boaz
authors.forename: Julio
authors.initials: J
authors.lastname: Weinstein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017674:Hypophosphatemia / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D011379:Prognosis; D012307:Risk Factors; D018805:Sepsis / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality*
chemical_list: D010710:Phosphates