title: Long-term remission in progressive multifocal leukoencephalopathy caused by idiopathic CD4+ T lymphocytopenia: a case report.
abstract: Progressive multifocal leukoencephalopathy is caused by JC virus, an opportunistic infection of the central nervous system. Antiretroviral treatment for progressive multifocal leukoencephalopathy in human immunodeficiency virus-infected patients is beneficial, but few data exist for patients who are not infected with human immunodeficiency virus. Idiopathic CD4+ T lymphocytopenia excludes human immunodeficiency virus infection. We describe a patient with progressive multifocal leukoencephalopathy with underlying idiopathic CD4+ T lymphocytopenia in whom functional recovery occurred without antiviral therapy.
authors.affiliation: Department of Neurology, University Hospital of Cologne, Cologne, Germany.
authors.forename: M A
authors.initials: MA
authors.lastname: Rueger
authors.forename: H
authors.initials: H
authors.lastname: Miletic
authors.forename: K
authors.initials: K
authors.lastname: Dorries
authors.forename: C
authors.initials: C
authors.lastname: Wyen
authors.forename: C
authors.initials: C
authors.lastname: Eggers
authors.forename: M
authors.initials: M
authors.lastname: Deckert
authors.forename: G
authors.initials: G
authors.lastname: Faetkenheuer
authors.forename: A H
authors.initials: AH
authors.lastname: Jacobs
mesh_terms: D000328:Adult; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications*