title: Evaluation of a new third-generation ELISA for the detection of HIV infection.
abstract: The purpose of this study was to assess whether the LG Anti-HIV 1/2 Plus ELISA (LG Life Sciences, Seoul, Korea), a new third-generation enzyme-linked immunosorbent assay for the detection of HIV infection, has improved sensitivity and specificity in comparison to the other licensed third-generation assays. The sensitivity of the LG Anti-HIV 1/2 Plus ELISA was comparable to the Enzygnost Anti-HIV 1/2 Plus ELISA (Dade Behring, Marburg, Germany) (100% vs 100%), and it was capable of detecting highly divergent subtypes including HIV-1 group O. The specificity of the LG Anti-HIV 1/2 Plus ELISA was 100%. The concordance of the LG Anti-HIV 1/2 Plus ELISA and the Enzygnost Anti-HIV 1/2 Plus was found to be 1. The LG Anti-HIV 1/2 Plus ELISA has a short window period among the third-generation ELISA assays and this test showed satisfactory reproducibility.
authors.affiliation: Dept. of Microbiology, Gachon Medical School, 1198, Kuwol-dong, Namdong-gu, Incheon 405-760, Korea (South).
authors.forename: Joon-Sup
authors.initials: JS
authors.lastname: Yeom
authors.forename: Jae-Beom
authors.initials: JB
authors.lastname: Lee
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Ryu
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Kang
authors.forename: Sunhil
authors.initials: S
authors.lastname: Kim
authors.forename: Young-A
authors.initials: YA
authors.lastname: Kim
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Ahn
authors.forename: Je-Eun
authors.initials: JE
authors.lastname: Cha
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Park
mesh_terms: D015492:AIDS Serodiagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000175:diagnosis* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D015498:HIV-2 / Q000145:classification* / Q000235:genetics; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D015483:HIV Antibodies