title: Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma.
abstract: In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesn't inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.
authors.affiliation: Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. rgosens@mich.ca
authors.forename: Reinoud
authors.initials: R
authors.lastname: Gosens
authors.forename: Dedmer
authors.initials: D
authors.lastname: Schaafsma
authors.forename: S Adriaan
authors.initials: SA
authors.lastname: Nelemans
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Halayko
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D001980:Bronchi / Q000378:metabolism*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D020742:rhoA GTP-Binding Protein