Cyano-phosphorylation of aldehydes catalyzed by a nucleophilic N-heterocyclic carbene.
The first method for cyano-phosphorylation of aldehydes with diethyl cyanophosphonate in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride and KOt-Bu, as a nucleophilic catalyst, is described.
Fukuda
Yoshimasa
Y
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Japan.
Maeda
Yuka
Y
Kondo
Kazuhiro
K
Aoyama
Toyohiko
T
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D010766:Phosphorylation; D013055:Spectrophotometry, Infrared
C510522:1,3-bis(2,4,6-trimethylphenyl)imidazolium; D000447:Aldehydes; D006571:Heterocyclic Compounds; D006838:Hydrocarbons; D007093:Imidazoles; D007202:Indicators and Reagents; C030011:carbene; D008697:Methane