title: Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder.
abstract: Dorsal anterior cingulate cortex (dACC) has been found to function abnormally in attention deficit hyperactivity disorder (ADHD) patients in several former functional MRI (fMRI) studies. Resting-state low-frequency fluctuations (LFFs) of blood oxygen level-dependent (BOLD) fMRI signals have been proved to be quite informative. This study used resting-state LFFs to investigate the resting-state functional connectivity pattern differences of dACC in adolescents with and without ADHD. As compared to the controls, the ADHD patients exhibited more significant resting-state functional connectivities with the dACC in bilateral dACC, bilateral thalamus, bilateral cerebellum, bilateral insula and bilateral brainstem (pons). No brain region in the controls was found to exhibit more significant resting-state functional connectivity with the dACC. We suggest these abnormally more significant functional connectivities in the ADHD patients may indicate the abnormality of autonomic control functions in them.
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Tian
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Meng
authors.initials: M
authors.lastname: Liang
authors.forename: Manqiu
authors.initials: M
authors.lastname: Sui
authors.forename: Qingjiu
authors.initials: Q
authors.lastname: Cao
authors.forename: Siyuan
authors.initials: S
authors.lastname: Hu
authors.forename: Miao
authors.initials: M
authors.lastname: Peng
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhuo
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010100:Oxygen / Q000097:blood; D012146:Rest / Q000502:physiology*
chemical_list: D010100:Oxygen