title: Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids.
abstract: BACKGROUND
  Low levels of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA, 22:6n3), are implicated in postpartum depression.
  
  
  METHODS
  The effects of pregnancy and lactation on brain phospholipid fatty acid content were determined in female rats fed diets containing sufficient (control) or negligible (deficient) alpha-linolenic acid (18:3n-3), the dietary precursor of DHA, beginning at conception. Female virgins, fed the diets for 6 weeks, served as control animals. Whole brain total phospholipid composition was determined at weaning by GC.
  
  
  RESULTS
  Brain DHA content of postpartum dams fed the deficient diet was decreased by 21% compared with age-matched virgin control animals, with a reciprocal increase in docosapentaenoic acid (22:5n6) to 243%.
  
  
  CONCLUSIONS
  Under dietary conditions supplying inadequate n-3 PUFAs, maternal brain DHA content can be reduced after a single reproductive cycle. This depletion may affect neuronal function and thus the sensitivity of the postpartum organism to stress.
authors.affiliation: Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. blevant@kumc.edu
authors.forename: Beth
authors.initials: B
authors.lastname: Levant
authors.forename: Jeffery D
authors.initials: JD
authors.lastname: Radel
authors.forename: Susan E
authors.initials: SE
authors.lastname: Carlson
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004032:Diet; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D049590:Postpartum Period / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D015525:Fatty Acids, Omega-3; D004281:Docosahexaenoic Acids