title: New self-assembled nanogels based on host-guest interactions: characterization and drug loading.
abstract: We show here, for the first time, that two neutral polymers may completely associate together in water to spontaneously form supramolecular nanoassemblies (nanogels) of spherical shape. The cohesion of these stable structures of about 200 nm is based upon a "lock and key" mechanism: inclusion complexes are formed between the hydrophobic alkyl chains grafted on a polysaccharide (dextran) and the molecular cavities contained in a poly-cyclodextrin polymer. Production yields reached 95%. It was established that all the alkyl chains were included within the cyclodextrins' cavities in these nanoassemblies. The multivalent character of the interactions between the two polymers ensures the stability of the nanoassemblies. Moreover, empty cyclodextrin units remained accessible for the inclusion of compounds of interest such as benzophenon or tamoxifen.
authors.affiliation: School of Pharmacy, Université Paris Sud, UMR CNRS 8612, 5 Rue J. B. Clément, 92290 Châtenay Malabry, France. ruxanda.gref@cep.u-psud.fr
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
authors.forename: Catherine
authors.initials: C
authors.lastname: Amiel
authors.forename: Karine
authors.initials: K
authors.lastname: Molinard
authors.forename: Samia
authors.initials: S
authors.lastname: Daoud-Mahammed
authors.forename: Bernard
authors.initials: B
authors.lastname: Sébille
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gillet
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Beloeil
authors.forename: Catherine
authors.initials: C
authors.lastname: Ringard
authors.forename: Véronique
authors.initials: V
authors.lastname: Rosilio
authors.forename: Jaques
authors.initials: J
authors.lastname: Poupaert
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry; D001577:Benzophenones / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers; D005782:Gels; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D049329:Nanostructures; D011108:Polymers / Q000737:chemistry*; D013500:Surface Tension; D013629:Tamoxifen / Q000737:chemistry; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D018931:Antineoplastic Agents, Hormonal; D001577:Benzophenones; D003911:Dextrans; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; D047392:beta-Cyclodextrins; D014867:Water; D013629:Tamoxifen; C047723:benzophenone