title: Acute laryngotracheobronchitis and associated transient hyperphosphatasemia: a new case of transient hyperphosphatasemia in early childhood.
abstract: We report the case of a 20-month old boy with markedly elevated serum alkaline phosphatase (ALP) levels, documented during an episode of acute laryngotracheobronchitis. Biochemical investigations and imaging studies revealed no evidence of bone or liver disease. Transient hyperphosphatasemia (TH) was confirmed when serum ALP levels normalized within 2 months. Several theories were suggested for TH pathophysiology, viral infections among them; the exact causes, however, remain unclear. It is important to recognize TH and avoid misdiagnosis and unnecessary investigations.
authors.affiliation: 4th Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece. eboriad@med.auth.gr
authors.forename: Maria
authors.initials: M
authors.lastname: Eboriadou
authors.forename: Georgia
authors.initials: G
authors.lastname: Skouli
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Panagopoulou
authors.forename: Katerina
authors.initials: K
authors.lastname: Haidopoulou
authors.forename: Artemis
authors.initials: A
authors.lastname: Makedou
authors.forename: George
authors.initials: G
authors.lastname: Varlamis
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D019819:Budesonide / Q000008:administration & dosage; D003440:Croup / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009330:Nebulizers and Vaporizers; D010760:Phosphorus Metabolism Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007527:Isoenzymes; D019819:Budesonide; D000469:Alkaline Phosphatase; D008775:Methylprednisolone