title: Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury.
abstract: Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.
authors.affiliation: First Department of Internal Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu-shi Gifu 501-1194, Japan. kkimura@cc.gifu-u.ac.jp
authors.forename: Kiminori
authors.initials: K
authors.lastname: Kimura
authors.forename: Masahito
authors.initials: M
authors.lastname: Nagaki
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
authors.forename: Shinichi
authors.initials: S
authors.lastname: Satake
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kuwata
authors.forename: Hisataka
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D002461:Cell Line, Transformed; D002999:Clone Cells; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D008099:Liver / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism / Q000821:virology
chemical_list: D000906:Antibodies; D008263:Macrophage Migration-Inhibitory Factors