Designing and running clinical trials on farms.
This article covers the key concepts in design and implementation of clinical trials for valid, interpretable data. Well done field trials should include a clearly defined research question and assessment of a clinically relevant outcome, an appropriate sample size for the question and study design, an appropriate trial design that includes random assignment of animals to treatment and control group, blinded assessment of clinical outcome, and appropriate statistical analysis.
Sanderson
Michael W
MW
Department of Clinical Sciences, 111B Mosier Hall, Kansas State University, Manhattan, 66506-5706, USA. sandersn@vet.k-state.edu
D000818:Animals; D000829:Animals, Domestic; D002986:Clinical Trials as Topic / Q000379:methods / Q000662:veterinary*; D015340:Epidemiologic Research Design / Q000662:veterinary*; D011897:Random Allocation; D018570:Risk Assessment; D018401:Sample Size; D014730:Veterinary Medicine / Q000379:methods / Q000458:organization & administration