title: Primary Gougerot-Sjögren syndrome: a dermatological approach.
abstract: Gougerot-Sjögren syndrome (GSS) is a chronic heterogeneous non-organ-specific autoimmune disease, encompassing a wide spectrum of clinical manifestations. It is characterized by a lymphocytic infiltration of the exocrine glands, also called epitheliitis, resulting in xerostomia and keratoconjunctivitis sicca. The skin can also be involved; for example, xerosis is a consequence of epitheliitis. Dermatological consequences of polyclonal reactivity are vasculitis and manifestations of B-cell proliferation vary from plasma cell infiltrates to B-cell lymphoma.
authors.affiliation: Laboratory of Immunology, Brest University Medical School, 2 avenue Foch, 29609 Brest Cedex, France. anne-marie.roguedas-contios@chu.brest.fr
authors.forename: A-M
authors.initials: AM
authors.lastname: Roguedas
authors.forename: P
authors.initials: P
authors.lastname: Youinou
authors.forename: G
authors.initials: G
authors.lastname: Lemasson
authors.forename: Y-L
authors.initials: YL
authors.lastname: Pennec
authors.forename: L
authors.initials: L
authors.lastname: Misery
mesh_terms: D006801:Humans; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology