[Psychophysiological analysis of bipolar disorder treatment with functional magnetic resonance imaging (fMRI), spectroscopic (1H-MRS) and volumetric MRI assessment of CNS: report of three cases].
BACKGROUND
Neuroimaging studies, including MRI, have identified various abnormalities in patients with bipolar disorders. However those findings have been inconsistent with regard to different MRI techniques, clinical and neurocognitive assessments as well as treatment results. So far the functional magnetic resonance imaging (fMRI) studies haven't been performed in psychiatric patients in Poland.


OBJECTIVE
The aim of the present study was to use fMRI, as well as two other MRI techniques to examine their relationships with clinical and neurocognitive assessments and the effectiveness of psychiatric treatment of bipolar disorders.


METHODS
In this preliminary report, three bipolar patients were tested and compared with one healthy subject by means of three MRI techniques: fMRI, prefrontal spectroscopy (1H-MRS) and volumetric MRI of hippocampus regions. Clinical (MADRS) and neurocognitive (Stroop-like) assessments were performed.


RESULTS
Clinical, cognitive and MRI findings (fMRI, 1H-MRS, vMRI) were highly or moderately correlated.


CONCLUSIONS
MRI techniques may effectively support both clinical and neurocognitive assessments of the ongoing treatment in bipolar patients.
Loza
Bartosz
B
Pracownia Zaburzeń Afektywnych AM w Warszawie.
Królicki
Leszek
L
Papierski
Klaudiusz
K
Mazurek
Iwona
I
Mosiołek
Anna
A
Kokoszka
Andrzej
A
Andrysiak
Renata
R
D001714:Bipolar Disorder / Q000503:physiopathology* / Q000628:therapy*; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D016896:Treatment Outcome