The ASK1-MAP kinase pathways in immune and stress responses.
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.
Hayakawa
Teruyuki
T
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Matsuzawa
Atsushi
A
Noguchi
Takuya
T
Takeda
Kohsuke
K
Ichijo
Hidenori
H
D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology / Q000378:metabolism; D004330:Drosophila / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000378:metabolism; D048848:MAP Kinase Kinase Kinase 5 / Q000737:chemistry / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000276:immunology / Q000502:physiology*; D013312:Stress, Physiological / Q000276:immunology / Q000503:physiopathology*; D051193:Toll-Like Receptors / Q000378:metabolism
D051193:Toll-Like Receptors; D048848:MAP Kinase Kinase Kinase 5