title: Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues.
abstract: A series of analogues of andrographolide were synthesized and evaluated as novel alpha-glucosidase inhibitors. Among them compound 23, 15-p-methoxylbenzylidene 14-deoxy-11,12-didehydroandrographolide, was a potent inhibitor against alpha-glucosidase whose IC(50) value was 16microM. The structure-activity relationships were also discussed.
authors.affiliation: New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450052, PR China.
authors.forename: Gui-Fu
authors.initials: GF
authors.lastname: Dai
authors.forename: Hai-Wei
authors.initials: HW
authors.lastname: Xu
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Feng-Wu
authors.initials: FW
authors.lastname: Liu
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; C030419:andrographolide