[G6PD phenotype and red blood cell sensitivity to the oxidising action of chlorites in drinking water].
Chlorine dioxide is widely used to replace sodium hypochlorite in the disinfection of surface waters for human consumption, in order to avoid or reduce the formation of organohalogenated compounds with mutagenic and carcinogenic activity. However, chlorine dioxide may lead to the formation of by-products, such as chlorites and chlorates, that have an oxidative effect on the blood corpuscled fraction. In this investigation, blood crasis was assessed in relation to the G6PD phenotype and the consumption of tap water, disinfected with chlorine dioxide, or bottled mineral water from non-disinfected underground sources. The results show that the effect of oxidative stress resulting from the uptake of chlorites with drinking water is not additive to the effect due to G6PD deficiency. The observed change in haematological parameters, including those related to the G6PD polymorphism, is always within the normal range. However, it is still possible that more relevant changes would follow exposure to chlorites concentrations greater than that observed in the present study.
Contu
A
A
Dipartimento di Sanità Pubblica, Sezione di Igiene, Università degli Studi di Cagliari. acontu@unica.it
Bajorek
M
M
Carlini
M
M
Meloni
P
P
Cocco
P
P
Schintu
M
M
D002712:Chlorides / Q000032:analysis / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D010084:Oxidation-Reduction; D010641:Phenotype; D014867:Water / Q000737:chemistry*
D002712:Chlorides; D014867:Water; D005954:Glucosephosphate Dehydrogenase; C001599:chlorite