Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity.
A new trinorcycloartane triterpenoid, lancifodilactone H (1), and a new A ring-secocycloartane triterpenoid, lancifoic acid A (2), together with a known compound, nigranoic acid (3), were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic data analysis. Compound 1 features a biosynthetically modified seven-membered lactone ring, which was confirmed by single-crystal X-ray diffraction. Compounds 1-3 exhibited weak anti-HIV-1 activity in vitro.
Xiao
Wei-Lie
WL
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Tian
Ren-Rong
RR
Pu
Jian-Xin
JX
Li
Xian
X
Wu
Li
L
Lu
Yang
Y
Li
Sheng-Hong
SH
Li
Rong-Tao
RT
Zheng
Yong-Tang
YT
Zheng
Qi-Tai
QT
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C508831:lancifodilactone H; C508832:lancifoic acid A; C100860:nigranoic acid