Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus.
Ten years following identification of Reelin as the product of the gene mutated in reeler mice, the signalling pathway activated by Reelin is being progressively unravelled with the identification of lipoprotein receptors as reelin receptors, of the Dab1 adapter and of some other proximal components in target cells. However, we are still a long way from understanding the action of this complex protein during brain development and maturation. The present review is organized in two parts. First, we summarize our present understanding of Reelin signalling. Then, we review critically some cell biological mechanisms for the action of Reelin based on recent studies on the development of the dentate gyrus, which has proved an extremely useful and tractable model system.
Förster
Eckart
E
Institut für Anatomie und Zellbiologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 17, D-79104 Freiburg, Germany.
Jossin
Yves
Y
Zhao
Shanting
S
Chai
Xuejun
X
Frotscher
Michael
M
Goffinet
André M
AM
D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D018891:Dentate Gyrus / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000166:cytology*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases