Nepalensinols D-G, new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase II.
Four new resveratrol oligomers, nepalensinols D-G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5-15 microM.
Yamada
Masashi
M
Meiji Dairies Corporation, Shinsuna, Tokyo, Japan.
Hayashi
Ken-Ichiro
K
Hayashi
Hiroshi
H
Tsuji
Ryota
R
Kakumoto
Kazuyuki
K
Ikeda
Shogo
S
Hoshino
Takuji
T
Tsutsui
Ken
K
Tsutsui
Kimiko
K
Ito
Tetsuro
T
Iinuma
Munekazu
M
Nozaki
Hiroshi
H
D029785:Cyperaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D000077185:Resveratrol; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
D004791:Enzyme Inhibitors; D010636:Phenols; D013267:Stilbenes; D059005:Topoisomerase II Inhibitors; D000077185:Resveratrol