title: Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice.
abstract: We investigated the effects of bovine LF (bLF) on different phases of NNK-induced lung tumorigenesis in A/J mice. Mice were orally administered 0.02, 0.2 and 2% bLF during the initiation phase, and 2% bLF during the whole tumorigenesis phase or post-initiation phase. Administered bLF during the post-initiation phase showed significant reduction of macroscopical lung nodules, and immunohistochemically decreased expression levels of cell proliferation marker and increased expression levels of apoptosis marker in lung proliferative lesions. bLF might inhibit NNK-induced mouse lung tumorigenesis, only when given limited to the post-initiation phase, through modification of cell proliferation and/or apoptosis.
authors.affiliation: Department of Pathology and Host-Defense, Faculty of Medicine, Onco-Pathology, Kagawa University, 1750-1 Ikenobe, Kida-Gun, Kagawa, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Kousuke
authors.initials: K
authors.lastname: Saoo
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hosokawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamakawa
authors.forename: Masanao
authors.initials: M
authors.lastname: Yokohira
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.forename: Hijiri
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imaida
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D053148:Caspase 3 / Q000032:analysis; D002417:Cattle; D019587:Dietary Supplements; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D007781:Lactoferrin / Q000008:administration & dosage / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D051379:Mice; D008805:Mice, Inbred A; D009602:Nitrosamines; D009929:Organ Size / Q000187:drug effects; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
chemical_list: D009602:Nitrosamines; D018809:Proliferating Cell Nuclear Antigen; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D007781:Lactoferrin; D053148:Caspase 3