Successful use of genotypic resistance testing in HIV-1-infected individuals with detectable viraemia between 50 and 1000 copies/ml.
Traditionally an HIV viral load of over 1000 copies/ml was presumed necessary for genotypic resistance testing. We performed a retrospective analysis to assess rates of viral amplification on viral loads between 50 and 1000 copies/ml. Amplification was significantly more likely for 200-1000 copies/ml than 50-200 copies/ml; most samples amplified successfully, supporting the use of genotyping for low-level viraemia.
Waters
Laura
L
Department of Genitourinary and HIV Medicine, St Stephens Centre, Chelsea and Westminster Hospital, London, UK.
Mandalia
S
S
Asboe
David
D
D016009:Chi-Square Distribution; D004279:DNA, Viral / Q000032:analysis*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019562:Viral Load
D004279:DNA, Viral