[Selenium and the activities of cyclooxygenase and lipoxygenase in cells involved in atherogenesis].
OBJECTIVE
This paper presents the properties of selenium, its content in food, and health effects of Se deficiency.


METHODS
The role of Se in the prevention of cardiovascular diseases, including atherosclerosis, is discussed.


RESULTS
The authors review the literature on interactions of Se with key enzymes participating in the synthesis of eicosanoids and on its regulatory properties with regard to contractility of blood vessels and blood coagulation.
Serwatka
Katarzyna
K
Katedra i Zakład Biochemii i Chemii Pomorskiej Akademii Medycznej al Powstańców Wlkp 72, Szczecin.
Stachowska
Ewa
E
Chlubek
Dariusz
D
D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000517:prevention & control*; D004730:Endothelium, Vascular / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008084:Lipoxygenase / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D012643:Selenium / Q000172:deficiency / Q000378:metabolism* / Q000627:therapeutic use*
D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D012643:Selenium