title: Hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage.
abstract: Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3-6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.
authors.affiliation: Pharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nishihashi
authors.forename: Cristina C
authors.initials: CC
authors.lastname: Trandafir
authors.forename: Aimin
authors.initials: A
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Ji
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kurahashi
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000187:drug effects* / Q000503:physiopathology; D017665:Hydroxyl Radical / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D013997:Time Factors; D014661:Vasoconstriction
chemical_list: D017665:Hydroxyl Radical