title: The impact of bioactive molecules to stimulate tooth repair and regeneration as part of restorative dentistry.
abstract: After implantation in the exposed pulp, some molecules of the den-tin extracellular matrix induce the formation of a reparative dentinal bridge in the coronal pulp. In some cases, total occlusion of the root canal also is observed. This is the case for bone sialoprotein, bone morphogenetic protein-7, Dentonin (a fragment from matrix extracellular phosphoglycoprotein), and two small amelogenin gene splice products (A+4 and A-4). Cells implicated in the reparative process are recruited, proliferate, and differentiate into osteoblast-like and odontoblast-like cells. The same results may be obtained by direct implantation of odontoblast progenitor cell into the pulp.
authors.affiliation: Laboratoire de Réparation et Remodelage des Tissus Oro-Faciaux, Groupe Matrices Extracellulaires et Biomineralisations, Faculté de Chirurgie Dentaire, Université René Descartes, Montrouge, France. mgoldod@aol.com
authors.forename: Michel
authors.initials: M
authors.lastname: Goldberg
authors.forename: Sally
authors.initials: S
authors.lastname: Lacerda-Pinheiro
authors.forename: Nadege
authors.initials: N
authors.lastname: Jegat
authors.forename: Ngampis
authors.initials: N
authors.lastname: Six
authors.forename: Dominique
authors.initials: D
authors.lastname: Septier
authors.forename: Fabienne
authors.initials: F
authors.lastname: Priam
authors.forename: Mireille
authors.initials: M
authors.lastname: Bonnefoix
authors.forename: Kevin
authors.initials: K
authors.lastname: Tompkins
authors.forename: Hélène
authors.initials: H
authors.lastname: Chardin
authors.forename: Pamela
authors.initials: P
authors.lastname: Denbesten
authors.forename: Arthur
authors.initials: A
authors.lastname: Veis
authors.forename: Anne
authors.initials: A
authors.lastname: Poliard
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism / Q000627:therapeutic use*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003785:Dental Pulp Capping / Q000379:methods*; D003793:Dental Restoration, Permanent / Q000379:methods*; D003804:Dentin / Q000166:cytology / Q000378:metabolism* / Q000601:surgery; D016326:Extracellular Matrix Proteins / Q000378:metabolism / Q000627:therapeutic use*; D006023:Glycoproteins / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D058574:Integrin-Binding Sialoprotein; D010750:Phosphoproteins / Q000378:metabolism / Q000627:therapeutic use; D051381:Rats; D012795:Sialoglycoproteins / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; C546871:IBSP protein, human; D058574:Integrin-Binding Sialoprotein; C486579:MEPE protein, human; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D002126:Calcium Hydroxide