title: Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter.
abstract: Liver receptor homologue 1 (LRH-1) plays important roles in many physiological processes and embryogenesis. However, little is known about the developmental regulation of lrh-1 expression. We identified a novel transcript of mouse lrh-1 (mlrh-1v2) from embryonic stem (ES) cells. mlrh-1v2 is expressed throughout embryogenesis and in several adult tissues, while the known transcript (mlrh-1v1) appears later during embryogenesis. mlrh-1v2 expression is directed by a new promoter which displays a strong activity in ES cells. The generation of the new transcript is conserved in rats. The identification of novel mlrh-1 variant and promoter is critical for elucidating LRH-1 functions in development and adult tissues.
authors.affiliation: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, S212, Yueyang Road 320, Shanghai 200031, China.
authors.forename: Da-ming
authors.initials: DM
authors.lastname: Gao
authors.forename: Lin-fang
authors.initials: LF
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Yu-ying
authors.initials: YY
authors.lastname: Kong
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: You-hua
authors.initials: YH
authors.lastname: Xie
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D017124:Conserved Sequence; D004622:Embryo, Mammalian / Q000166:cytology; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D014644:Genetic Variation; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D013234:Stem Cells / Q000378:metabolism*
chemical_list: C431936:Nr5a2 protein, mouse; D018160:Receptors, Cytoplasmic and Nuclear