title: Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample.
abstract: Glutamatergic dysfunction is one of the major hypotheses for the pathogenesis of schizophrenia. The GRIA1 gene encodes for one (GluR1) of the four (GluR1-4) ionotropic AMPA receptor subunits. GRIA1 is a good candidate gene for susceptibility to schizophrenia since it maps in 5q33, a region where the presence of susceptibility loci has been suggested by independent genome-wide scans and because its expression has been found to be decreased in the brain of some schizophrenia patients. We present data from a case-control association study on the Italian population with eight polymorphisms spanning the whole GRIA1 gene. Single-locus analysis revealed a significantly different allele distribution in cases and in controls of two SNPs (rs707176, 0.41 vs. 0.31, P = 0.009; rs2963944, 0.41 vs. 0.30, P = 0.007), and one microsatellite (rs10631988, allele 9: 0.40 vs. 0.29, P = 0.004). Haplotype analysis showed an increased frequency of a specific haplotype for these markers (C09CC, 0.39 vs. 0.28, P = 0.009). Therefore our data indicate that GRIA1 may be involved in susceptibility to DSM-IV-TR schizophrenia.
authors.affiliation: Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Magri
authors.forename: Rita
authors.initials: R
authors.lastname: Gardella
authors.forename: Stefano Davide
authors.initials: SD
authors.lastname: Barlati
authors.forename: Damiano
authors.initials: D
authors.lastname: Podavini
authors.forename: Paraskevas
authors.initials: P
authors.lastname: Iatropoulos
authors.forename: Silvia
authors.initials: S
authors.lastname: Bonomi
authors.forename: Paolo
authors.initials: P
authors.lastname: Valsecchi
authors.forename: Emilio
authors.initials: E
authors.lastname: Sacchetti
authors.forename: Sergio
authors.initials: S
authors.lastname: Barlati
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D018091:Receptors, AMPA / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
chemical_list: D018091:Receptors, AMPA