[Acute colitis closely following the beginning of celecoxib treatment].
Selective inhibitors of cyclooxygenase-2 have less gastroduodenal toxicity than non selective anti-inflammatory drugs. However, there is little information on their effect on the distal gut. A 91 year old woman presented with acute diarrhoea 5 weeks after beginning celecoxib treatment. Laboratory results showed an inflammatory syndrome and increased alanine aminotransferase (ALT) to 13 N. Endoscopic examination of the colon showed diffuse erythematous lesions of the sigmoid and of part of the right colon. No aetiology has been found for colitis or hepatitis. Diarrhea and blood test anomalies disappeared one week after celecoxib was stopped. The role of celecoxib in the etiology of colitis was considered plausible but not for liver damage. This report and a few other cases in the literature suggest that cyclooxygenase-2 selective non-steroidal anti-inflammatory drug inhibitor toxicity should be investigated in case of unexplained acute colitis.
Houmani
Zaher
Z
Service d'Hépato-Gastroentérologie, Centre Hospitalier, 8 avenue Henri Adnot, 60321 Compiègne Cedex. Zaher99abir@aol.com
Imbert
Audrey
A
Duchmann
Jean-Christophe
JC
Messerschmitt
Claude
C
Barbare
Jean-Claude
JC
Latrive
Jean-Paul
JP
Biour
Michel
M
D000208:Acute Disease; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001416:Back Pain / Q000188:drug therapy; D000068579:Celecoxib; D003092:Colitis / Q000139:chemically induced*; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D006801:Humans; D011720:Pyrazoles / Q000008:administration & dosage / Q000009:adverse effects*; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000410:Alanine Transaminase; D000068579:Celecoxib