Combined diphtheria-tetanus-pertussis vaccine for tetanus-prone wound management in adults.
BACKGROUND
Booster vaccination against tetanus, diphtheria and pertussis is recommended throughout life. Adults are difficult to reach and vaccination coverage in this group is often inadequate. The use of a reduced-antigen content combined diphtheria-tetanus-acellular pertussis ('adult' dTpa) vaccine for tetanus prophylaxis in emergency room wound management provides an opportunity to boost immunity against three infections simultaneously, thereby optimizing the efficiency of medical interventions with adults assessed.


METHODS
A single-blind, randomized, controlled study of 320 healthy adults, the anti-tetanus antibody response within 10 days following vaccination with Boostrix (reduced-antigen diphtheria-tetanus-acellular pertussis).


RESULTS
The anti-tetanus antibody response to the reduced-antigen diptheria-tetanus-acellular pertussis vaccine was equivalent to Tetavax, a licensed monovalent tetanus-toxoid vaccine.


CONCLUSIONS
The use of diphtheria-tetanus-acellular pertussis is a safe and effective way to provide vaccination to adults against three diseases during emergency room visits for wound management.
Hoel
Terje
T
Vaccination Clinic, Department of Infectious Diseases, Ulleval University Hospital, Oslo, Norway.
Wolter
Joanne M
JM
Schuerman
Lode M
LM
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D003017:Clostridium tetani / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D013742:Tetanus / Q000276:immunology / Q000517:prevention & control*; D014946:Wound Infection / Q000517:prevention & control
D000907:Antibodies, Bacterial; C505143:Boostrix; D015721:Diphtheria-Tetanus-Pertussis Vaccine