Synthesis, thermodynamics stability constant and relaxation properties of neutral Gd(III) complex with derivative from diethylene triamine pentaacetic acid and p-hydroxybenzoyl hydrazine.
A novel ligand, diethylenetriamine-N,N''-bis(acetyl-p-hydroxybenzoyl hydrazine)-N,N',N''-triacetic acid (H3L) was synthesized and characterized on the basis of elemental analysis, molar conductivity, 1H-NMR spectrum, FAB-MS, TG-DTA analysis and IR spectrum. Its complex of Gd(III) holding promise of magnetic resonance imaging (MRI) was synthesized, and relaxivity (R1) of complex and Gd(DTPA)2- used as a control was determined in water solution, respectively. The relaxivity of GdL (R1 = 6.39 l.mmol(-1).s(-1)) was larger than that of Gd(DTPA)2- (R1 = 4.34 l.mmol(-1).s(-1)). The relaxivity of GdL has also been investigated in human serum albumin (HSA) solution, the relaxivity of GdL was enhanced from 6.39 l.mmol(-1).s(-1) in water solution to 7.69 l.mmol(-1).s(-1) in HSA solution. In addition, thermodynamics stability constant of GdL was determined. The results showed that complex of GdL is a prospective MRI contrast agent, although the thermodynamic stability constant of GdL complex (K(GdL) = 10(19.56)) was a little less than that of Gd(DTPA)2- (K(Gd-DTPA) = 10(20.73)).
Zhang
Ding-Wa
DW
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering Lanzhou University, Gansu, PR China.
Yang
Zheng-Yin
ZY
Zhang
Shi-Ping
SP
Yang
Ru-Dong
RD
D003287:Contrast Media / Q000138:chemical synthesis*; D004055:Differential Thermal Analysis; D019786:Gadolinium DTPA / Q000737:chemistry*; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D007202:Indicators and Reagents; D008024:Ligands; D008279:Magnetic Resonance Imaging; D004369:Pentetic Acid / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics
D003287:Contrast Media; D006834:Hydrazines; D007202:Indicators and Reagents; D008024:Ligands; D012709:Serum Albumin; D012996:Solutions; D004369:Pentetic Acid; C004297:3-hydroxybenzylhydrazine; D019786:Gadolinium DTPA