Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population.
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p=0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
Takahashi
Nagahide
N
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ishihara
Ryoko
R
Saito
Shinichi
S
Maemo
Nobuhisa
N
Aoyama
Nagisa
N
Ji
Xiofei
X
Miura
Hideki
H
Ikeda
Masashi
M
Iwata
Nakao
N
Suzuki
Tatsuyo
T
Kitajima
Tsuyoshi
T
Yamanouchi
Yoshio
Y
Kinoshita
Yoko
Y
Ozaki
Norio
N
Inada
Toshiya
T
D000328:Adult; D016022:Case-Control Studies; D053379:Chromogranin A; D002864:Chromogranins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D017421:Sequence Analysis
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins