Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury.
The introduction of new iron chelating drugs may ultimately improve iron-chelation therapy for patients with iron overload diseases such as thalassaemia and other disorders. In this paper, the in vivo effects of baicalin and quercetin on iron overload induced liver injury were studied on mice. It was found that when iron-dextran induced iron overload mice were fed baicalin or quercetin containing diet (1% w/w) for 45 days, both flavonoids significantly inhibited iron overload induced lipid peroxidation and protein oxidation of liver, decreased hepatic iron and hepatic collagen content, increased the serum non-heme iron level but not serum ferritin level. Flavonoids supplementation also increased the excretion of iron through feces. In vitro study demonstrated that both flavonoids could release iron from ferritin. These results indicate that besides acting as antioxidants, both flavonoids can also release iron from liver and finally excrete it through feces. The present study provides further support for flavonoids to be medicines for iron overload diseases.
Zhang
Yan
Y
Department of Chemistry, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China.
Li
Hailing
H
Zhao
Yuling
Y
Gao
Zhonghong
Z
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D019587:Dietary Supplements; D005293:Ferritins / Q000097:blood / Q000378:metabolism; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007501:Iron / Q000097:blood / Q000378:metabolism / Q000652:urine; D019190:Iron Overload / Q000139:chemically induced / Q000150:complications*; D007505:Iron-Dextran Complex / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000293:injuries / Q000378:metabolism; D008107:Liver Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D011506:Proteins; C038044:baicalin; D007505:Iron-Dextran Complex; D003094:Collagen; D005293:Ferritins; D011794:Quercetin; D007501:Iron