title: Alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis.
abstract: One new prenylated 1,4-anthraquinone and three new prenylated anthranols, named kengaquinone (1) and kenganthranols A (2), B (3), and C (4), were isolated from a hexane extract of the stem bark of Harungana madagascariensis. Six known compounds including anthraquinones, anthrones, and xanthones were also isolated and identified. The structures of the new compounds were determined by analysis of spectroscopic data and comparison with data of previously known analogues. Some isolated compounds (3-5, 7-11) were evaluated for their alpha-glucosidase inhibition activity. Compounds 3, 4, 8, and 11 showed significant activity, whereas compounds 7, 9, and 10 were inactive in this test.
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon.
authors.forename: Simeon F
authors.initials: SF
authors.lastname: Kouam
authors.forename: Shamsun Nahar
authors.initials: SN
authors.lastname: Khan
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Deccaux G W F
authors.initials: DG
authors.lastname: Kapche
authors.forename: Diane B
authors.initials: DB
authors.lastname: Yapna
authors.forename: Seema
authors.initials: S
authors.lastname: Zareem
authors.forename: Amal M Y
authors.initials: AM
authors.lastname: Moustafa
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000875:Anthralin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D000520:alpha-Glucosidases / Q000032:analysis*
chemical_list: D000880:Anthraquinones; D004791:Enzyme Inhibitors; C508817:kenganthranol A; C508818:kenganthranol B; C508819:kenganthranol C; C508816:kengaquinone; D000520:alpha-Glucosidases; D000875:Anthralin