title: Anti-tumor activity of Titanocene Y in xenografted Caki-1 tumors in mice.
abstract: The benzyl-substituted unbridged titanocene bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (Titanocene Y) was tested in vitro against human renal cancer cells (Caki-1), in which it showed an IC50 value of 36 x 10 mol/l. Titanocene Y was then given in vivo in doses of 10, 20, 30, 40 and 50 mg/kg on 5 consecutive days to Caki-1-bearing mice, and it showed concentration-dependent and statistically significant tumor growth reduction with respect to a solvent-treated control cohort. The maximum tolerable dose of Titanocene Y was determined to be 40 mg/kg and it showed significantly better tumor volume growth reduction than cisplatin given at a dose of 2 mg/kg. This superior activity of Titanocene Y with respect to cisplatin will hopefully lead to clinical tests against metastatic renal cell cancer in the near future.
authors.affiliation: aMax Delbrück Center for Molecular Medicine, Berlin, Germany.
authors.forename: Iduna
authors.initials: I
authors.lastname: Fichtner
authors.forename: Clara
authors.initials: C
authors.lastname: Pampillón
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Sweeney
authors.forename: Katja
authors.initials: K
authors.lastname: Strohfeldt
authors.forename: Matthias
authors.initials: M
authors.lastname: Tacke
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology; D048708:Cell Growth Processes / Q000187:drug effects; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009942:Organometallic Compounds / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C507878:bis((4-methoxybenzyl)cyclopentadienyl)titanium(IV) dichloride