[Patient-controlled intravenous analgesia with sufentanil and fentanyl after thoracotomy: a comparative study].
OBJECTIVE
To evaluate the clinical efficacy of sufentanil and fentanyl at equivalent dose for patient-controlled intravenous analgesia (PCIA) after thoracotomy.


METHODS
Sixty ASA I-II patients (20-60 years of age) undergoing radical operation for lung or esophageal cancer were randomly divided into sufentanil intravenous analgesia group (group S, with sufentanil 1 microg/ml) and fentanyl intravenous analgesia group (group F, fentanyl 10 microg/ml). PCIA was administered with background infusion of 2.5 ml/h, bolus injection of 2.5 ml and lockout time of 15 min. The pain intensity according to visual analogue scale (VAS), cumulative analgesic consumption (CAC), sedative scores and side effects at 24 and 48 h after administration were recorded. SpO(2), respiratory rate (RR), blood pressure (BP) and ECG were continuously monitored.


RESULTS
There were no significant differences in CAC between the two groups, but he VAS was lower in group S than in group F (P<0.05) and the sedative efficacy was superior in group S (P<0.05). The incidence of nausea and vomiting in group S was lower than that in group F (P<0.05). No significant differences were observed in SpO(2), RR, heart rate and mean arterial pressure between the two groups.


CONCLUSIONS
PCIA with sufentanil provides better efficacy of analgesia and sedation with lower incidence of nausea and vomiting than with fentanyl in postoperative patients with thoracotomy.
Lin
Chun-shui
CS
Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lcsliuyu@fimmu.com
Lu
Gang
G
Ruan
Luo-yang
LY
Gu
Miao-ning
MN
D000328:Adult; D016058:Analgesia, Patient-Controlled; D004938:Esophageal Neoplasms / Q000601:surgery; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010149:Postoperative Pain / Q000188:drug therapy*; D017409:Sufentanil / Q000008:administration & dosage* / Q000009:adverse effects; D013908:Thoracotomy; D014839:Vomiting / Q000139:chemically induced
D017409:Sufentanil; D005283:Fentanyl