title: [Adrenal androgen and bone metabolism].
abstract: Dehydroepiandrosterone-sulfate (DHEA-S), the sulfated form of dehydroepiandrosterone, is the most abundant steroids in human, although its biological activities are seemingly weak. Recently, basic and clinical observations suggest dehydroepiandrosterone (DHEA) increase bone mineral densities in the elderly. Large-scale double-blinded clinical trials are necessary.
authors.affiliation: Kasamatsu-kai Medical Corporation Ariyoshi Hospital, Internal Medicine and the Elderly Care.
authors.forename: Kiminobu
authors.initials: K
authors.lastname: Goto
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanase
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
authors.forename: Hajime
authors.initials: H
authors.lastname: Nawata
mesh_terms: D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000378:metabolism; D010006:Osteoblasts / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases
chemical_list: D004967:Estrogens; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; C500554:DDSP protein, human; D017027:Protein Tyrosine Phosphatases