[The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina].
OBJECTIVE
The aim of this study is to compare lipoprotein (a) [Lp(a)] levels in patients with low and high risk unstable angina pectoris, which is defined according to the cardiac troponin-I (Tn-I) levels and to investigate their relation with myocardial damage.


METHODS
From patients with chest pain; venous blood samples were collected for measuring serum Lp(a) and C-reactive protein (CRP) levels on admission and serum cTn-I levels 12 and 24 hours after admission. Fifty-nine patients with serum cTn-I levels <1.0 ng/ml were assigned as negative unstable angina group and 53 patients with serum cTn-I levels >or=1.0 ng/ml were assigned as positive unstable angina groups, respectively. Severity of coronary artery disease was determined by angiography in all patients.


RESULTS
Compared with cTn-I negative group, Lp(a) levels were significantly higher in cTn-I positive group (52.9+/-6.0 mg/dl vs 15.7+/-2.5 mg/dl, p<0.0001). There was a significant correlation between Lp(a) and cTn-I levels (r=0.870, p=0.0001). We could not establish any correlation between Lp(a) levels and Gensini score or between multiple vessel disease and low density lipoprotein cholesterol levels (p>0.05). Also, there was no significant difference between cTn-I positive and negative groups with respect to Gensini score (p>0.05).


CONCLUSIONS
Increased Lp(a) levels and significant relation between Lp(a) and cTn-I levels support the opinion that Lp(a) can be a risk factor for plaque destabilization and thrombosis rather than severity of coronary artery disease in patients with high risk unstable angina. Furthermore, high levels of Lp(a) may be related with myocardial injury in patients with unstable angina.
Yazici
Mustafa
M
Ondokuz Mayis Universitesi Tip Fakültesi, Kardiyoloji Anabilim Dali, Kurupelit 55139 - Samsun-Türkiye. drmeyaz@hotmail.com
Demircan
Sabri
S
Ibrahimli
Firdovsi
F
Aksakal
Emre
E
Sahin
Mahmut
M
Sağkan
Olcay
O
D000789:Angina, Unstable / Q000097:blood* / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography / Q000379:methods; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology*; D003328:Coronary Thrombosis / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology; D011237:Predictive Value of Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D019210:Troponin I / Q000097:blood*
D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D019210:Troponin I; D002097:C-Reactive Protein