Role of bone morphogenetic proteins in transitional cell carcinoma cells.
Bone morphogenetic proteins (BMPs) are pleiotropic growth factors that signal through an interaction with the membrane receptors-type--IA, -IB, and -II (BMP-RIA, -RIB, and -RII, respectively). Although the prototypical members of this group of growth factors were isolated as osteoinductive factors, recently accumulated data have suggested that these factors regulate malignant cells. Herein, we review the data concerning BMPs in transitional cell carcinoma cells.
Kim
Isaac Yi
IY
Division of Urologic Oncology, The Cancer Institute of New Jersey, 195 Little Albany Street #4560, New Brunswick, NJ 08903, USA. kimiy@umdnj.edu
Kim
Seong Jin
SJ
D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000503:physiopathology*; D045744:Cell Line, Tumor; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000503:physiopathology*
D019485:Bone Morphogenetic Proteins