title: Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains.
abstract: The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.
authors.affiliation: National Institute of Public Health, 30/34 Chelmska St., 00-725 Warsaw, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Sabat
authors.forename: Damian C
authors.initials: DC
authors.lastname: Melles
authors.forename: Gayane
authors.initials: G
authors.lastname: Martirosian
authors.forename: Hajo
authors.initials: H
authors.lastname: Grundmann
authors.forename: Alex
authors.initials: A
authors.lastname: van Belkum
authors.forename: Waleria
authors.initials: W
authors.lastname: Hryniewicz
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics; D002353:Carrier State / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D016106:Methicillin Resistance / Q000235:genetics; D018598:Minisatellite Repeats; D009296:Nasal Cavity / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; D004269:DNA, Bacterial; C118508:SdrC protein, Staphylococcus aureus; C115915:SdrD protein, Staphylococcus aureus; C118507:SdrE protein, Staphylococcus aureus