Prognosis of cough variant asthma: a retrospective analysis.
Patients with cough variant asthma, a common cause of chronic cough, may develop wheezing. We examined the determinants of this phenomenon and achievement of remission in 42 patients. During 4 years after diagnosis, wheezing developed in 13 of the patients. Early inhaled corticosteroid treatment was inhibitory against the development of wheezing by univariate analysis and by multivariate analysis with an odds ratio of 0.12 (95% confidence interval, 0.02 to 0.87, p = 0.037). Remission was achieved in 7 patients, who were younger than those without remission by univariate analysis (p = 0.048). Early treatment with inhaled corticosteroid may prevent the progression of cough variant asthma to classic asthma.
Matsumoto
Hisako
H
Department of Respiratory Medicine, Kyoto University, Kyoto, Japan.
Niimi
Akio
A
Takemura
Masaya
M
Ueda
Tetsuya
T
Tabuena
Rollin
R
Yamaguchi
Masafumi
M
Matsuoka
Hirofumi
H
Hirai
Toyohiro
T
Muro
Shigeo
S
Ito
Yutaka
Y
Mio
Tadashi
T
Chin
Kazuo
K
Nishiyama
Hideki
H
Mishima
Michiaki
M
D000328:Adult; D001249:Asthma / Q000150:complications*; D003371:Cough / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012135:Respiratory Sounds / Q000209:etiology*; D012189:Retrospective Studies