title: An efficient synthesis of 2-benzoxepines from Morita-Baylis-Hillman adducts using heterogeneous recyclable catalysts.
abstract: 2-Benzoxepines have efficiently been synthesized from Morita-Baylis-Hillman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO4.SiO2) or Amberlyst-15 in CH2Cl2 under reflux for a short period of time (1.5-2.5 h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.
authors.affiliation: Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad, India. biswanathdas@yahoo.com
authors.forename: Biswanath
authors.initials: B
authors.lastname: Das
authors.forename: Anjoy
authors.initials: A
authors.lastname: Majhi
authors.forename: Joydeep
authors.initials: J
authors.lastname: Banerjee
authors.forename: Nikhil
authors.initials: N
authors.lastname: Chowdhury
authors.forename: Harish
authors.initials: H
authors.lastname: Holla
authors.forename: Kankipati
authors.initials: K
authors.lastname: Harakishore
authors.forename: Upadhayula Suryanarayana
authors.initials: US
authors.lastname: Murty
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001584:Benzoxepins / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D002855:Chromatography, Thin Layer; D002939:Ciprofloxacin / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D001584:Benzoxepins; D007202:Indicators and Reagents; D002939:Ciprofloxacin