Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection.
OBJECTIVE
To compare perinatal outcomes in spontaneous twins compared with those conceived by intracytoplasmic sperm injection (ICSI).


METHODS
Retrospective case-control study.


METHODS
Cases consisted of 274 intracytoplasmic sperm injection twins, controls were 348 naturally conceived twins delivered between 1999 and 2003 in a tertiary hospital.


METHODS
Birth weight, gestational age at birth, cesarean delivery rate, perinatal mortality and morbidity, congenital anomalies, gestational diabetes and pregnancy induced hypertension.


RESULTS
Preterm deliveries (76.6% vs. 64.1% <37 weeks and 19.7% vs. 13.2% <32 weeks) and low birth weight (73% vs. 60.3% <2500 g and 19.7% vs. 12.6% <1500 g) were significantly higher in the ICSI group compared with controls. Gestational diabetes mellitus (8% vs. 2.9%) and cesarean deliveries (95.2% vs. 77.6%) were more common in cases compared with the control group. There was a significantly higher rate of perinatal morbidity (16.4% vs. 7.8%) and mortality (8% vs. 2.6%) in ICSI twins. The incidence of congenital malformations diagnosed at birth was higher in cases (4.4%) compared with controls (0.9%) but the difference was not significant when adjusted for maternal age.


CONCLUSIONS
Perinatal outcomes of twins after ICSI treatment are less optimal than naturally conceived twins.
Saygan-Karamürsel
Burcu
B
Hacettepe University Department of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey. Bkaramursel@mesa.com.tr
Tekşam
Ozlem
O
Aksu
Tarik
T
Yurdakök
Murat
M
Onderoğlu
Lütfü
L
D000328:Adult; D016022:Case-Control Studies; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins