title: Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis.
abstract: This case report describes congenital nephrotic syndrome in a 2-month-old girl associated with cytomegalovirus infection. Histological examination on renal biopsy showed diffuse mesangial sclerosis and cytomegalic inclusion bodies in the tubular cells and in some glomeruli. Cytomegalovirus (CMV) polymerase chain reaction (PCR) titer in serum was high. Remission of pulmonary and renal symptoms was achieved with ganciclovir in 3 weeks. No recurrence of proteinuria was observed during the follow-up period of 14 months. These finding suggested a causal relationship between congenital nephrotic syndrome and cytomegalovirus infection.
authors.affiliation: Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Besbas
authors.forename: Umut Selda
authors.initials: US
authors.lastname: Bayrakci
authors.forename: Gulsev
authors.initials: G
authors.lastname: Kale
authors.forename: Ali Bulent
authors.initials: AB
authors.lastname: Cengiz
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Akcoren
authors.forename: Devrim
authors.initials: D
authors.lastname: Akinci
authors.forename: Ilke
authors.initials: I
authors.lastname: Kilic
authors.forename: Aysin
authors.initials: A
authors.lastname: Bakkaloglu
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D005920:Glomerular Mesangium / Q000473:pathology* / Q000821:virology; D006801:Humans; D007181:Inclusion Bodies, Viral; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D009404:Nephrotic Syndrome / Q000151:congenital* / Q000473:pathology / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012598:Sclerosis
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir