Inhibition of T-cell responses by CD4 on an antigen-presenting cell.
In addition to T-helper cells, CD4 is expressed on monocytes, macrophages and dendritic cells. To see whether CD4 molecules on antigen-presenting cells affect T-cell responses, we expressed CD4 on Raji cells, and compared positive and negative cells as stimulator cells for peripheral blood mononuclear cells in mixed lymphocyte reactions. We found that expression of CD4 on Raji had an inhibitory effect on production of IFN-gamma and other cytokines.
Hansen
Torbjørn
T
The Gade Institute, Department of Microbiology and Immunology, University of Bergen, Norway. torbjorn.hansen@gades.uib.no
D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D015704:CD4 Antigens / Q000235:genetics / Q000276:immunology*; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D009154:Mutation; D013601:T-Lymphocytes / Q000276:immunology*; D014162:Transfection
D015704:CD4 Antigens; D016207:Cytokines; D007371:Interferon-gamma