[A new cause of intra and extrahepatic cholangitis: the drug hypersensitivity syndrome or DRESS (Drug Rash with Eosinophilia and Systemic Symptoms)].
The DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) corresponds to a drug reaction generally including cutaneous eruption, fever, hematologic abnormalities such as eosinophilia and atypical lymphocytosis and one or more specific visceral lesions specially in the liver. We report a case of drug hypersensitivity syndrome or DRESS associated with intra and extra-hepatic biliary lesions. This syndrome was associated with sulfasalazine and naproxene therapy. A reactivation of HHV6 was documented in the continuations of the DRESS and could play a role in the symptomms.
Condat
Bertrand
B
Services d'Hépato-Gastroentérologie, Hôpital Saint-Camille, Bry-sur-Marne. B.Condat@ch-bry.org
Zanditenas
David
D
Collot
Véronique
V
Legoupil
Nathalie
N
Cazals-Hatem
Dominique
D
Hauuy
Marie-Pierre
MP
Bonnet
Joëlle
J
Ngo
Yann
Y
Roucoules
Jacques
J
Blazquez
Martine
M
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002761:Cholangitis / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000150:complications*; D004802:Eosinophilia / Q000139:chemically induced; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D008297:Male; D009288:Naproxen / Q000009:adverse effects* / Q000627:therapeutic use; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine; D009288:Naproxen