Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution.
Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates geared to simplified preparation without biochemical blood handling. In this initial article, we describe the conceptual and technical evolution from fibrin glues to platelet concentrates. This retrospective analysis is necessary for the understanding of fibrin technologies and the evaluation of the biochemical properties of 3 generations of surgical additives, respectively fibrin adhesives, concentrated platelet-rich plasma (cPRP) and PRF. Indeed, the 3-dimensional fibrin architecture is deeply dependent on artificial clinical polymerization processes, such as massive bovine thrombin addition. Currently, the slow polymerization during PRF preparation seems to generate a fibrin network very similar to the natural one. Such a network leads to a more efficient cell migration and proliferation and thus cicatrization.
Dohan
David M
DM
Biophysics Laboratory, Faculty of Dental Surgery, University of Paris V, Paris, France. drdohand@hotmail.com
Choukroun
Joseph
J
Diss
Antoine
A
Dohan
Steve L
SL
Dohan
Anthony J J
AJ
Mouhyi
Jaafar
J
Gogly
Bruno
B
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D002417:Cattle; D002469:Cell Separation / Q000379:methods; D002921:Cicatrix; D005337:Fibrin / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology / Q000648:ultrastructure; D015718:Fibrin Tissue Adhesive / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005782:Gels; D006490:Hemostatics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D044367:Phase Transition; D010974:Platelet Aggregation / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects*
D015718:Fibrin Tissue Adhesive; D005782:Gels; D006490:Hemostatics; D005337:Fibrin