Pretransplant conditioning in adults and children: dose assurance with intravenous busulfan.
OBJECTIVE
To provide clinical insights into dosing and administration of IV busulfan, a conditioning agent for hematopoietic stem cell transplantation (HSCT).


METHODS
Review of published literature related to busulfan pretransplant conditioning using MEDLINE. Meeting abstracts, investigational protocols, and pharmaceutical manufacturers' package inserts also were reviewed.


RESULTS
Busulfan is an effective myeloablative conditioning agent for HSCT. The IV formulation increases dose assurance and the ability to target a therapeutic window. Therapeutic drug monitoring ensures that targeted blood levels are achieved, especially in children, thereby preventing underdosing, which can lead to disease progression or rejection, as well as overdosing, which can cause an increased risk of toxic side effects.


CONCLUSIONS
IV busulfan is a convenient, safe, and effective conditioning agent used in HSCT that has a predictable pharmacokinetic profile.


CONCLUSIONS
An understanding of the pharmacokinetic principles underlying the relationship between the therapeutic window for busulfan and optimal HSCT outcomes will facilitate proper dosing and administration of IV busulfan.
Fisher
Vicki L
VL
Pediatric Blood and Marrow Transplant Program, University Hospitals of Cleveland, USA. vicki.fisher@uhhs.com
Barnes
Yvonne J
YJ
Nuss
Suzanne L
SL
D000284:Administration, Oral; D000328:Adult; D002066:Busulfan / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D007223:Infant; D007262:Infusions, Intravenous; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D019172:Transplantation Conditioning / Q000379:methods*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D002066:Busulfan