Neuroprotective 2-(2-phenylethyl)chromones of Imperata cylindrica.
Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylchromone (4). Among these four compounds, 1 and 2 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.
Yoon
Jeong Seon
JS
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea.
Lee
Mi Kyeong
MK
Sung
Sang Hyun
SH
Kim
Young Choong
YC
D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018698:Glutamic Acid / Q000494:pharmacology*; D007723:Korea; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D006109:Poaceae / Q000737:chemistry*; D051381:Rats; D027343:Rhizome
C508837:5-hydroxy-2-(2-phenylethyl)chromone; D002867:Chromones; D018696:Neuroprotective Agents; D018698:Glutamic Acid