title: Autoimmune progesterone dermatitis.
abstract: Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by recurrent polymorphous skin manifestations, which appear or are exacerbated during the luteal phase of the menstrual cycle. The hallmarks for diagnosis include premenstrual flare, its prevention with the inhibition of ovulation, and positive skin reaction to intradermal injection of progesterone. The mainstay of treatment is to inhibit the secretion of endogenous progesterone by suppressing ovulation. Bilateral oophorectomy may be necessary in patients with severe and refractory symptoms. We report herein the case of a 38-year-old woman who developed recurrent and cyclic vesiculobullous eruptions clinically suggestive of erythema multiforme or autoimmune bullous diseases. The skin manifestations turned out to be APD. The patient was treated with tamoxifen 20 mg daily with complete symptom remission after 4 months.
authors.affiliation: Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Cocuroccia
authors.forename: Paolo
authors.initials: P
authors.lastname: Gisondi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Gubinelli
authors.forename: Giampiero
authors.initials: G
authors.lastname: Girolomoni
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D003872:Dermatitis / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000276:immunology* / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism*; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen; D011374:Progesterone