title: Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population.
abstract: It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p=0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
authors.affiliation: Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Nagahide
authors.initials: N
authors.lastname: Takahashi
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ishihara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Saito
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Maemo
authors.forename: Nagisa
authors.initials: N
authors.lastname: Aoyama
authors.forename: Xiofei
authors.initials: X
authors.lastname: Ji
authors.forename: Hideki
authors.initials: H
authors.lastname: Miura
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Tatsuyo
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitajima
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D053379:Chromogranin A; D002864:Chromogranins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D017421:Sequence Analysis
chemical_list: C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins