Expression of Toll-like receptors in the kidney: their potential role beyond infection.
Toll-like receptors (TLRs) recognize both exogenous microbial components and endogenous molecules to promote immune activation. Both immune and nonimmune renal cells express TLRs, which are involved in the pathogenesis of a number of kidney diseases, including pyelonephritis, Leptospira nephritis, immune-complex glomerulonephritis, ischemic/reperfusion injury, and rejection of kidney transplant.
Schroppel
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Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA.
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D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology; D007668:Kidney / Q000276:immunology*; D007674:Kidney Diseases / Q000209:etiology / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*
D051193:Toll-Like Receptors