title: Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep.
abstract: Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrP(Sc) in the spleen.
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Andréoletti
authors.affiliation: CEA, Service de Pharmacologie et d'Immunologie, CEA/Saclay, 91191 Gif sur Yvette cedex, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Morel
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lacroux
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Rouillon
authors.affiliation: INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Barc
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Tabouret
authors.affiliation: INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Sarradin
authors.affiliation: INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Berthon
authors.affiliation: INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bernardet
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Jacinthe
authors.initials: J
authors.lastname: Mathey
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Lugan
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Pierrette
authors.initials: P
authors.lastname: Costes
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Corbière
authors.affiliation: CISA, Instituto National de Investigacion y Tecnologia Agraria y Alimentaria, 28130 Valdeolmos, Spain.
authors.forename: Juan-Carlos
authors.initials: JC
authors.lastname: Espinosa
authors.affiliation: CISA, Instituto National de Investigacion y Tecnologia Agraria y Alimentaria, 28130 Valdeolmos, Spain.
authors.forename: Juan Maria
authors.initials: JM
authors.lastname: Torres
authors.affiliation: CEA, Service de Pharmacologie et d'Immunologie, CEA/Saclay, 91191 Gif sur Yvette cedex, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Grassi
authors.affiliation: UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France.
authors.forename: François
authors.initials: F
authors.lastname: Schelcher
authors.affiliation: INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lantier
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015153:Blotting, Western; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000378:metabolism* / Q000635:transmission*; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry; D012756:Sheep; D012757:Sheep Diseases / Q000378:metabolism* / Q000635:transmission*; D013154:Spleen / Q000378:metabolism*