The emergence of new drugs for overactive bladder.
Overactive bladder is a common and distressing problem. Standard therapy is directed towards modifying the detrusor motor sensitivity and response via anticholinergic medication. Currently available medications are reviewed and alternative targets for treatment are presented.
McCrery
Rebecca J
RJ
Division of Voiding Dysfunction & Female Urology, Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.
Smith
Phillip P
PP
Appell
Rodney A
RA
D000109:Acetylcholine / Q000378:metabolism; D000588:Amines / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001559:Benzhydryl Compounds / Q000494:pharmacology / Q000627:therapeutic use; D003408:Cresols / Q000494:pharmacology / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D000077206:Gabapentin; D006801:Humans; D008333:Mandelic Acids / Q000494:pharmacology / Q000627:therapeutic use; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D010665:Phenylpropanolamine / Q000494:pharmacology / Q000627:therapeutic use; D011358:Product Surveillance, Postmarketing; D011812:Quinuclidines / Q000494:pharmacology / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D043587:Receptor, Muscarinic M3 / Q000037:antagonists & inhibitors / Q000378:metabolism; D000069464:Solifenacin Succinate; D044005:Tetrahydroisoquinolines / Q000494:pharmacology / Q000627:therapeutic use; D000068737:Tolterodine Tartrate; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000378:metabolism; D014549:Urinary Incontinence / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000627:therapeutic use
D000588:Amines; D000927:Anticonvulsants; D001559:Benzhydryl Compounds; D003408:Cresols; D003509:Cyclohexanecarboxylic Acids; D008333:Mandelic Acids; D018727:Muscarinic Antagonists; D011812:Quinuclidines; D043587:Receptor, Muscarinic M3; D044005:Tetrahydroisoquinolines; D010665:Phenylpropanolamine; D005680:gamma-Aminobutyric Acid; D000068737:Tolterodine Tartrate; D000077206:Gabapentin; C005419:oxybutynin; D000069464:Solifenacin Succinate; D000109:Acetylcholine