Natural products from cyanobacteria: Exploiting a new source for drug discovery.
In the 1990s, the pharmaceutical industry shifted its focus to a combinatorial chemistry approach to fill drug-discovery pipelines; however, more recently there has been renewed interest in natural products as sources of lead compounds. Cyanobacteria are prolific producers of natural products displaying enormous chemical diversity, yet, until recently, exploitation of the genera was hampered by a number of issues related to their handling. With most of these problems now resolved, cyanobacteria have the potential to expand the variety of natural products obtained from microorganisms. The relative disregard in the past of cyanobacteria compared with other microbial sources of natural products, as well as the huge chemical diversity and biological activities of their products, recommend them as an attractive source of novel drugs for use in diverse therapeutic areas.
Sielaff
Heike
H
Cyano Biotech GmbH, Chausseestrasse 117, D-10115 Berlin, Germany.
Christiansen
Guntram
G
Schwecke
Torsten
T
D001688:Biological Products / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D020650:Combinatorial Chemistry Techniques; D000458:Cyanobacteria / Q000145:classification / Q000378:metabolism; D015195:Drug Design; D015394:Molecular Structure
D001688:Biological Products