Studies of HIV-associated immune responses in lymphoid compartments.
Acute HIV-1 infection results in profound depletion of CD4+ memory T cells in lymphoid tissue (LT) and subsequent persistent replication in activated CD4+ T cells despite induction of an HIV-specific cell-mediated immune response. Interferon-alpha, proinflammatory cytokines, and beta-chemokine production is present in LT. However, impaired expression of co-stimulatory molecules including CD80, CD86, and CD40L may contribute to low polyfunctional CD4+ T cell as well CD8+ T-cell activity. Accumulation of regulatory CD4+ T cells in LT may add to the lack of HIV-specific CD4+ T-cell proliferation and dysfunctional cytotoxic CD8+ T-cell response in LT.
Grundström
Susanna
S
Division of Infectious Diseases and Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden.
Andersson
Jan
J
D015704:CD4 Antigens / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology; D003712:Dendrites / Q000276:immunology / Q000473:pathology; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D015704:CD4 Antigens; D016827:CD8 Antigens