title: Non-palpable ductal carcinoma in situ (DCIS) with microinvasion arising in a radial scar presenting with spiculation alone on mammograms: a case report.
abstract: A case of ductal carcinoma in situ (DCIS) with microinvasion arising in a radial scar of the breast is presented. A 57-year-old woman visited our hospital with bloody discharge from her left nipple. There were no abnormal findings on cytology, carcinoembryonic antigen (CEA) level of nipple discharge was <500 ng/ml, and mammograms were normal. After 2 years of careful periodic follow-up, spiculation without a central core appeared on mammograms. The CEA level of the nipple discharge increased to 1,000 ng/ml. Ductgraphy showed a connection between the duct with the discharge and the center of the spiculation. Since these findings suggested malignancy, she underwent segmentectomy of the breast, and pathological examination showed a radial scar and DCIS with microinvasion in the ducts within the radiating bands of fibrous tissues. We discuss the characteristics of a radial scar and its relationship to breast cancer based on our experience and a review of the literature.
authors.affiliation: Department of Surgery, National Hospital Organization, Shikoku Cancer Center Horinouchi 13, Matsuyama, 790-0007, Japan. aokita@shikoku-cc.go.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Okita
authors.forename: Shozo
authors.initials: S
authors.lastname: Ohsumi
authors.forename: Shigemitsu
authors.initials: S
authors.lastname: Takashima
authors.forename: Riki
authors.initials: R
authors.lastname: Okita
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Aogi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Saeki
authors.forename: Akira
authors.initials: A
authors.lastname: Kurita
authors.forename: Rieko
authors.initials: R
authors.lastname: Nishimura
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008327:Mammography; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging / Q000379:methods; D009558:Nipples / Q000378:metabolism*; D011379:Prognosis