An XML-based system for synthesis of data from disparate databases.
Diverse data sets have become key building blocks of translational biomedical research. Data types captured and referenced by sophisticated research studies include high throughput genomic and proteomic data, laboratory data, data from imagery, and outcome data. In this paper, the authors present the application of an XML-based data management system to support integration of data from disparate data sources and large data sets. This system facilitates management of XML schemas and on-demand creation and management of XML databases that conform to these schemas. They illustrate the use of this system in an application for genotype-phenotype correlation analyses. This application implements a method of phenotype-genotype correlation based on phylogenetic optimization of large data sets of mouse SNPs and phenotypic data. The application workflow requires the management and integration of genomic information and phenotypic data from external data repositories and from the results of phenotype-genotype correlation analyses. Our implementation supports the process of carrying out a complex workflow that includes large-scale phylogenetic tree optimizations and application of Maddison's concentrated changes test to large phylogenetic tree data sets. The data management system also allows collaborators to share data in a uniform way and supports complex queries that target data sets.
Kurc
Tahsin
T
Biomedical Informatics Department, Ohio State University, 3184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA. kurc@bmi.osu.edu
Janies
Daniel A
DA
Johnson
Andrew D
AD
Langella
Stephen
S
Oster
Scott
S
Hastings
Shannon
S
Habib
Farhat
F
Camerlengo
Terry
T
Ervin
David
D
Catalyurek
Umit V
UV
Saltz
Joel H
JH
D000818:Animals; D003327:Coronary Disease / Q000235:genetics; D003628:Database Management Systems; D030541:Databases, Genetic; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016247:Information Storage and Retrieval; D010641:Phenotype; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D011381:Programming Languages; D018511:Systems Integration