A balancing act between the X chromosome and the autosomes.
Dosage compensation equalizes gene dosage between males and females, but its role in balancing expression between the X chromosome and the autosomes may be far more important. Now, DNA microarrays have shown equality between the average expression of X-linked genes and that of autosomal genes, in male and female tissues of flies, worms and mice.
Cheng
Mimi K
MK
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
Disteche
Christine M
CM
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D002875:Chromosomes; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D008297:Male; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D015854:Up-Regulation; D014960:X Chromosome