title: Anti-hyperglycemic Potential of Natural Products.
abstract: In order to evaluate the anti-hyperglycemic effect of natural compounds via the inhibition of alpha-glucosidase (AGH), the potential inhibitory effect of anthocyanins, caffeic acid analogs, and caffeoylquinic acid analogs have been reviewed. A new AGH assay system to mimic the membrane-bound AGH at the small intestine was proposed and evaluated.
authors.affiliation: Division of Food Biotechnology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tmatsui@agr.kyushu-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: I A
authors.initials: IA
authors.lastname: Ogunwande
authors.forename: K J M
authors.initials: KJ
authors.lastname: Abesundara
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology / Q000627:therapeutic use*; D002109:Caffeic Acids / Q000494:pharmacology / Q000627:therapeutic use; D002462:Cell Membrane / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D002109:Caffeic Acids; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C472707:caffeoylquinic acid; D011801:Quinic Acid; D000520:alpha-Glucosidases