title: Frequency of unexpected and important histopathological findings in routine intervertebral disc surgery.
abstract: OBJECTIVE
  The value of routine histopathological examination of intervertebral disc tissue has been questioned, but sufficient numbers of studies have yet to be conducted to provide a definitive sense of its importance. The aim of this study was to investigate the nature and frequency of unexpected histopathological findings in intervertebral disc surgery.
  
  
  METHODS
  The authors conducted a retrospective examination of consecutive surgical specimens obtained in patients with benign indication for discectomy at four neurosurgical centers. Surgical specimens obtained during 2102 operations (2177 intervertebral discs) in 2017 patients were evaluated. In addition to one case of cavernous malformation, two specimens (obtained in 0.1% of patients) revealed unexpected pathological diagnoses of malignancy (metastasized prostate carcinoma and diffuse large B-cell lymphoma).
  
  
  CONCLUSIONS
  The results of this retrospective study suggest that routine histopathological examination of specimens obtained during intervertebral disc procedures is both justified and cost effective.
authors.affiliation: Department of Clinical Radiology, Institute of Neuropathology, University Hospital Münster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Hasselblatt
authors.forename: David
authors.initials: D
authors.lastname: Maintz
authors.forename: Thomas
authors.initials: T
authors.lastname: Goll
authors.forename: Uwe
authors.initials: U
authors.lastname: Wildförster
authors.forename: Christoph
authors.initials: C
authors.lastname: Schul
authors.forename: Werner
authors.initials: W
authors.lastname: Paulus
mesh_terms: D000328:Adult; D000368:Aged; D001165:Arteriovenous Malformations / Q000175:diagnosis; D017586:Diskectomy; D006801:Humans; D015994:Incidence; D007403:Intervertebral Disc / Q000473:pathology* / Q000601:surgery; D016393:Lymphoma, B-Cell / Q000175:diagnosis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000556:secondary