[The role of S100B-protein in neonatology, pediatric intensive care, and pediatrics].
During the last years neuromonitoring with various biochemical markers such as S100B protein has been introduced into the clinical settings of neonatal and pediatric intensive care. Several investigations have been undertaken to correlate S100B protein concentrations to the diagnosis and prognosis of neonates and children with severe cerebral disorders. This articles gives a review on the current knowledge, indications and limitations on the use of S100B protein after non-traumatic and traumatic brain injury in neonates and children.
Meyer
S
S
Klinik für Allgemeine Pädiatrie und Neonatologie. sascha.meyer@uniklinik-saarland.de
Gottschling
S
S
Baghai
A
A
Polcher
T
T
Strittmatter
M
M
Gortner
L
L
D000293:Adolescent; D000367:Age Factors; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000175:diagnosis; D001324:Autoantigens; D015415:Biomarkers; D001720:Birth Injuries / Q000097:blood / Q000175:diagnosis; D001927:Brain Diseases / Q000097:blood* / Q000175:diagnosis; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003422:Critical Care; D005260:Female; D015600:Glasgow Coma Scale; D006355:Heart-Lung Machine / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic; D009414:Nerve Growth Factors / Q000097:blood* / Q000134:cerebrospinal fluid; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood* / Q000134:cerebrospinal fluid; D012680:Sensitivity and Specificity; D012737:Sex Factors; D020521:Stroke / Q000097:blood / Q000175:diagnosis; D013997:Time Factors
D001324:Autoantigens; D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human