Whole-brain radiotherapy in the management of brain metastasis.
Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000 Americans annually. The prognosis for these patients is poor, with median survival times measured in months. In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of chemical modifiers and the management and prevention of neurocognitive deficits.
Khuntia
Deepak
D
University of Wisconsin, Madison, WI 53792, USA.
Brown
Paul
P
Li
Jing
J
Mehta
Minesh P
MP
D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D003071:Cognition; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D006801:Humans; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D016634:Radiosurgery
D011838:Radiation-Sensitizing Agents