Sonographic measurement of cervical length and fetal fibronectin testing in threatened preterm labor.
OBJECTIVE
In women presenting with threatened preterm labor, both fetal fibronectin and sonographic measurement of cervical length have been shown to distinguish between true and false labor. The aim of this study was to determine whether the combination of both tests provides a better prediction than the individual tests alone.


METHODS
We examined 195 women with singleton pregnancies presenting at 24-36 (median 31) weeks of gestation with regular and painful uterine contractions, intact membranes and cervical dilatation of less than 3 cm. On admission to the hospital fetal fibronectin positivity in cervicovaginal secretions was determined and transvaginal sonographic measurement of cervical length was carried out. The results were not made available to the attending obstetrician. The primary outcome measure was delivery within 7 days of presentation.


RESULTS
Delivery within 7 days occurred in 51.4% (18 of 35) of those with cervical length below 15 mm and 0.6% (1 of 160) of those with cervical length of 15 mm or more, in 21.2% (18 of 85) of the fibronectin positive group and in 0.9% (1 of 110) of the fibronectin negative group. There was a significant association between cervical length and the incidence of fibronectin positivity (r = -0.921, P = 0.003). Logistic regression analysis demonstrated that the only significant contributor to the prediction of delivery within 7 days was cervical length, with no significant contribution from fibronectin positivity, ethnic origin, maternal age, gestational age, body mass index, parity, previous history of preterm delivery, cigarette smoking, or use of tocolytics.


CONCLUSIONS
In women with threatened preterm labor assessment of fetal fibronectin in cervicovaginal secretions does not improve the prediction of delivery within 7 days provided by the sonographic measurement of cervical length.
Tsoi
E
E
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Akmal
S
S
Geerts
L
L
Jeffery
B
B
Nicolaides
K H
KH
D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002584:Cervix Uteri / Q000000981:diagnostic imaging*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005865:Gestational Age; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008423:Maternal Age; D007752:Obstetric Labor, Premature / Q000175:diagnosis*; D010298:Parity; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012372:ROC Curve; D044469:Racial Groups; D012008:Recurrence; D012044:Regression Analysis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal
D015415:Biomarkers; C403421:FFN protein, human; D005353:Fibronectins; D006023:Glycoproteins