title: Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder.
abstract: Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5' region, the coding region (exons 2-4), and the 3' noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD.
authors.affiliation: Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan. nakamura@hama-med.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Iwayama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Toyota
authors.forename: Aizou
authors.initials: A
authors.lastname: Furukawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takimoto
authors.forename: Hayato
authors.initials: H
authors.lastname: Terayama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwahashi
authors.forename: Nori
authors.initials: N
authors.lastname: Takei
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
authors.forename: Yoshimoto
authors.initials: Y
authors.lastname: Sekine
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Iwata
authors.forename: Anitha
authors.initials: A
authors.lastname: Pillai
authors.forename: Yurie
authors.initials: Y
authors.lastname: Nakamoto
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Yoshii
authors.forename: Isao
authors.initials: I
authors.lastname: Fukunishi
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020125:Mutation, Missense; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011963:Receptors, GABA-A / Q000235:genetics*
chemical_list: D011963:Receptors, GABA-A