title: Resection of colorectal liver metastases: current perspectives.
abstract: BACKGROUND
  Metastases to the liver is the leading cause of death in patients with colorectal cancer.
  
  
  METHODS
  The authors review the data on diagnosis and management of this clinical problem, and they discuss management options that can be considered.
  
  
  RESULTS
  Complete surgical resection of metastases from colorectal cancer that are localized to the liver results in 5-year survival rates ranging from 26% to 40%.
  
  
  CONCLUSIONS
  By adding modalities such as targeted systemic therapy and other "local" treatments for liver metastases, further gains in survival are anticipated.
authors.affiliation: Gastrointestinal Tumor Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612-9497, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: McLoughlin
authors.forename: Eric H
authors.initials: EH
authors.lastname: Jensen
authors.forename: Mokenge
authors.initials: M
authors.lastname: Malafa
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D020360:Neoadjuvant Therapy; D018579:Patient Selection; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome