Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood.
The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample.
Rayana
Mohammed C Ben
MC
Laboratory of Clinical Chemistry, National Institute of Nutrition, Bab Saadoun, Tunis, Tunisia.
Burnett
Robert W
RW
Covington
Arthur K
AK
D'Orazio
Paul
P
Fogh-Andersen
Niels
N
Jacobs
Ellis
E
Kataky
Ritu
R
Külpmann
Wolf R
WR
Kuwa
Katsuhiko
K
Larsson
Lasse
L
Lewenstam
Andrzej
A
Maas
Anton H J
AH
Mager
Gerhard
G
Naskalski
Jerzy W
JW
Okorodudu
Anthony O
AO
Ritter
Christoph
C
St John
Andrew
A
D000704:Analysis of Variance; D002138:Calibration; D002712:Chlorides / Q000097:blood*; D004563:Electrochemistry; D006801:Humans; D007201:Indicator Dilution Techniques; D017736:Ion-Selective Electrodes; D010783:Photometry; D010949:Plasma / Q000737:chemistry*; D011188:Potassium / Q000097:blood*; D012016:Reference Values; D015203:Reproducibility of Results; D012964:Sodium / Q000097:blood*; D017186:Titrimetry
D002712:Chlorides; D012964:Sodium; D011188:Potassium