Stressful life events, 5-HTT genotype and risk of depression.
Studies of how genetic and environmental exposures interact may be essential for understanding the aetiology of complex psychiatric disorders. In this issue of the Journal an Australian study reports evidence of such an interaction on risk of depression. We discuss findings in this field in the context of the limitations inherent in studies of gene-environment interactions.
Zammit
Stanley
S
Owen
Michael J
MJ
D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology; D019317:Evidence-Based Medicine; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D050486:Serotonin Plasma Membrane Transport Proteins