title: [Structural changes of the anterior chamber angle in primary congenital glaucoma with respect to normal development].
abstract: OBJECTIVE
  To compare findings of normal angles with those from primary congenital glaucoma in order to clarify the pathogenic mechanisms of the disease and to explain the success of surgical treatment in some of these patients.
  
  
  METHODS
  Adult normal eyes from cadavers and fragments of surgical trabeculectomies from patients with primary congenital glaucoma previously treated with goniotomy were studied. Eyes were processed for examination using light microscopy and scanning electron microscopy techniques.
  
  
  RESULTS
  The following was evident in congenital glaucoma: 1) high iris insertion; 2) no observable pre-trabecular membrane, but enlarged trabeculae with diminished inter-trabecular spaces; 3) Schlemm's canal (SC) apparently normal, with vacuoles in the wall indicating normal functioning; 4) sectioning of the abnormal trabecular tissue during goniotomy allowed repositioning of the angle structures and hence the appearance of the angular recess.
  
  
  CONCLUSIONS
  Anomalies of the trabecular structures in primary congenital glaucoma do not always parallel an abnormal development of the SC and the collector channels. This fact could explain the success of goniotomy in this type of glaucoma.
authors.affiliation: Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense, Madrid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Rojas
authors.forename: A I
authors.initials: AI
authors.lastname: Ramírez
authors.forename: R
authors.initials: R
authors.lastname: de-Hoz
authors.forename: J J
authors.initials: JJ
authors.lastname: Salazar
authors.forename: J M
authors.initials: JM
authors.lastname: Remírez
authors.forename: A
authors.initials: A
authors.lastname: Triviño
mesh_terms: D000867:Anterior Chamber / Q000473:pathology* / Q000648:ultrastructure; D005901:Glaucoma / Q000151:congenital* / Q000473:pathology*; D006801:Humans; D008855:Microscopy, Electron, Scanning