title: Physiologic and metabolic magnetic resonance imaging in gliomas.
abstract: Magnetic resonance (MR) imaging provides excellent soft tissue differentiation and in vivo assessment of physiologic and metabolic properties of tissue. As new and more aggressive treatment modalities and combined modalities are being investigated for brain tumor treatment, it is becoming more important to accurately define tumor volumes for treatment planning, to determine the most aggressive tumor regions for intensified radiation treatment, to identify early regional response to therapy for reoptimization of treatment, and to detect early indicators of developing normal tissue toxicity. Readily available MR techniques of physiologic and metabolic imaging can currently provide useful information regarding tumor tissue properties including chemical composition, cerebral blood volume, perfusion, vascular permeability, and water mobility. This article will focus on the potential value of MR physiologic and metabolic imaging in the clinical management of malignant gliomas.
authors.affiliation: Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0010, USA. yuecao@umich.edu
authors.forename: Yue
authors.initials: Y
authors.lastname: Cao
authors.forename: Pia C
authors.initials: PC
authors.lastname: Sundgren
authors.forename: Christina I
authors.initials: CI
authors.lastname: Tsien
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Chenevert
authors.forename: Larry
authors.initials: L
authors.lastname: Junck
mesh_terms: D016543:Central Nervous System Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging; D005910:Glioma / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy