title: High frequency of iatrogenic monozygotic twins with administration of clomiphene citrate and a change in chorionicity.
abstract: The data of the population-based, prospective survey of multiple births in East Flanders, Belgium, show that a greater proportion of monozygotic twins is observed with clomiphene citrate as sole treatment compared with other ovulatory drugs. Among iatrogenic monozygotic twins, the ratio of monochorionic versus dichorionic pairs is higher compared with spontaneous twins.
authors.affiliation: Center of Human Genetics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium. catherine.derom@uz.kuleuven.ac.be
authors.forename: Catherine
authors.initials: C
authors.lastname: Derom
authors.forename: Fernand
authors.initials: F
authors.lastname: Leroy
authors.forename: Robert
authors.initials: R
authors.lastname: Vlietinck
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Fryns
authors.forename: Robert
authors.initials: R
authors.lastname: Derom
mesh_terms: D002823:Chorion; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006062:Gonadotropins / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted; D014310:Triplets; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D005300:Fertility Agents, Female; D006062:Gonadotropins; D002996:Clomiphene