Central hypothyroidism with oxcarbazepine therapy.
Abnormalities in thyroid function with the use of several antiepileptic medications are thought to result from increased metabolism of thyroid hormone and interference with the hypothalamic-pituitary axis. Oxcarbazepine was developed to attempt to reduce the side effects that have traditionally been observed with antiepileptic drugs that induce the hepatic enzyme system. Increased metabolism of thyroid hormone should not occur in patients on oxcarbazepine as the hepatic enzyme system has minimal involvement in the metabolism of this medication. This report describes three patients who developed central hypothyroidism associated with oxcarbazepine treatment, suggesting that oxcarbazepine interferes with the hypothalamic-pituitary axis.
Miller
Jennifer
J
Department of Pediatrics, Division of Endocrinology, University of Florida College of Medicine, Gainesville, Florida 32610-0296, USA. millejl@peds.ufl.edu
Carney
Paul
P
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001827:Body Height / Q000187:drug effects; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D000078330:Oxcarbazepine; D012894:Sleep Stages; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D000927:Anticonvulsants; D002220:Carbamazepine; D013972:Thyrotropin; D013974:Thyroxine; D000078330:Oxcarbazepine