title: Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters.
abstract: In this study, tumour tissue samples of 85 primary breast cancer patients were evaluated for phosphatase and tensin homolog deleted on chromosome ten (PTEN), cyclin D1 and P27/Kip1 expression patterns. The results were correlated with clinicopathological parameters. Loss of PTEN protein expression was present in 32.5% of the cases. Cyclin D1 was overexpressed in 54.2% and P27/Kip1 in 89.3% of the cases. Statistically significant associations were found between PTEN and cyclin D1 expression patterns, and cyclin D1 expression and tumour size.
authors.affiliation: Karaelmas University Faculty of medicine, Department of internal medicine and medical oncology, 67600, Zonguldak, Turkey. bulengin@yahoo.com
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Engin
authors.forename: Esmen
authors.initials: E
authors.lastname: Baltali
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Güler
authors.forename: Gülnur
authors.initials: G
authors.lastname: Güler
authors.forename: Gülten
authors.initials: G
authors.lastname: Tekuzman
authors.forename: Aysegül
authors.initials: A
authors.lastname: Uner
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology*; D019938:Cyclin D1 / Q000096:biosynthesis*; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000096:biosynthesis*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000096:biosynthesis*
chemical_list: D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051059:PTEN Phosphohydrolase