title: Nitrosative/oxidative modifications and ageing.
abstract: We present here a brief description of the relationships among metals, nitric oxide metabolism, and ageing. In particular, we will discuss the interactions occurring between redox (copper, iron) and non-redox (zinc) metals and nitric oxide, the metal- and nitric oxide-catalyzed formation of thiol adducts (nitrosothiols, mixed disulphides) and the possible involvement of these species in the ageing process.
authors.affiliation: Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, University of Messina, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Musci
authors.forename: Tiziana
authors.initials: T
authors.lastname: Persichini
authors.forename: Manuela
authors.initials: M
authors.lastname: Casadei
authors.forename: Valeria
authors.initials: V
authors.lastname: Mazzone
authors.forename: Giorgio
authors.initials: G
authors.lastname: Venturini
authors.forename: Fabio
authors.initials: F
authors.lastname: Polticelli
authors.forename: Marco
authors.initials: M
authors.lastname: Colasanti
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D019216:Metals, Heavy / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009603:Nitroso Compounds / Q000378:metabolism; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D019216:Metals, Heavy; D009603:Nitroso Compounds; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D005978:Glutathione