Investigation of treatment failure in neonatal echovirus 7 infection.
We describe a case of fatal neonatal enteroviral infection caused by echovirus 7. Multiple treatments, including specific antiviral therapy, were attempted and failed. Studies of the viral isolate, maternal plasma, intravenous immunoglobulin preparations and pleconaril were performed to identify potential causes for treatment failure.
Rentz
Alison C
AC
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. alison.rentz@childrens.harvard.edu
Libbey
Jane E
JE
Fujinami
Robert S
RS
Whitby
Frank G
FG
Byington
Carrie L
CL
D000998:Antiviral Agents / Q000627:therapeutic use*; D029822:Enterovirus B, Human / Q000145:classification* / Q000187:drug effects / Q000235:genetics; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D008969:Molecular Sequence Data; D010069:Oxadiazoles / Q000627:therapeutic use*; D010080:Oxazoles; D017422:Sequence Analysis, DNA; D017211:Treatment Failure
D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D010069:Oxadiazoles; D010080:Oxazoles; C115201:pleconaril