Candida krusei transmission among hematology patients resolved by adapted antifungal prophylaxis and infection control measures.
A sudden increase in neutropenic hematology patients with Candida krusei colonization and bacteremia prompted a longitudinal epidemiological investigation. We identified 39 patients; 13 developed candidemia, and three died; 25 patients carried the same genotype. We intervened by changing antifungal prophylaxis and implementing strict infection control measures. The incidence dropped immediately.
Vos
Margreet C
MC
Department of Medical Microbiology & Infectious Diseases, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. m.vos@erasmusmc.nl
Endtz
Hubert P
HP
Horst-Kreft
Deborah
D
Doorduijn
Jeanette
J
Lugtenburg
Elly
E
Verbrugh
Henri A
HA
Löwenberg
Bob
B
de Marie
Siem
S
van Pelt
Cindy
C
van Belkum
Alex
A
D000935:Antifungal Agents / Q000008:administration & dosage; D002175:Candida / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission*; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D005838:Genotype; D006402:Hematologic Diseases / Q000150:complications; D006801:Humans; D008137:Longitudinal Studies; D009426:Netherlands / Q000453:epidemiology; D009503:Neutropenia / Q000150:complications
D000935:Antifungal Agents