The synthesis and use of boronated amino acids for boron neutron capture therapy.
The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.
Kabalka
George W
GW
Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, TN 37996-1600, USA. kabalka@utk.edu
Yao
Min-Liang
ML
D000596:Amino Acids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D001880:Boranes / Q000737:chemistry; D001895:Boron / Q000627:therapeutic use; D001896:Boron Compounds / Q000138:chemical synthesis*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001897:Boronic Acids / Q000737:chemistry; D005971:Glutamates / Q000737:chemistry; D006801:Humans; D007554:Isotopes / Q000627:therapeutic use
D000596:Amino Acids; D000970:Antineoplastic Agents; D001880:Boranes; D001896:Boron Compounds; D001897:Boronic Acids; D005971:Glutamates; D007554:Isotopes; C066302:2,4-methanoglutamate; D001895:Boron