title: Evaluation of RGS4 as a candidate gene for schizophrenia.
abstract: Several studies have suggested that the regulator of G-protein signaling 4 (RGS4) may be a positional and functional candidate gene for schizophrenia. Three single nucleotide polymorphisms (SNP) located at the promoter region (SNP4 and SNP7) and the intron 1 (SNP18) of RGS4 have been verified in different ethnic groups. Positive results have been reported in these SNPs with different numbers of SNP combinatory haplotypes. In this study, these three SNP markers were genotyped in 218 schizophrenia pedigrees of Taiwan (864 individuals) for association analysis. Among these three SNPs, neither SNP4, SNP7, SNP18 has shown significant association with schizophrenia in single locus association analysis, nor any compositions of the three SNP haplotypes has shown significantly associations with the DSM-IV diagnosed schizophrenia. Our results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated from these three SNP markers.
authors.affiliation: Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Liu
authors.forename: Cathy
authors.initials: C
authors.lastname: Shen-Jang Fann
authors.forename: Chih-Min
authors.initials: CM
authors.lastname: Liu
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.forename: Shuen-Iu
authors.initials: SI
authors.lastname: Hung
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Chan
authors.forename: Jiahn-Jyh
authors.initials: JJ
authors.lastname: Chen
authors.forename: Chin-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Shih-Kai
authors.initials: SK
authors.lastname: Liu
authors.forename: Ming H
authors.initials: MH
authors.lastname: Hsieh
authors.forename: Tzung-Jeng
authors.initials: TJ
authors.lastname: Hwang
authors.forename: Wen-Chen
authors.initials: WC
authors.lastname: Ouyang
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Chen
authors.forename: Jin-Jia
authors.initials: JJ
authors.lastname: Lin
authors.forename: Frank Huang-Chih
authors.initials: FH
authors.lastname: Chou
authors.forename: Ching-Mo
authors.initials: CM
authors.lastname: Chueh
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Liu
authors.forename: Ming-Min
authors.initials: MM
authors.lastname: Tsuang
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
mesh_terms: D000483:Alleles; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D020710:RGS Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D013624:Taiwan
chemical_list: D020710:RGS Proteins; C098799:RGS4 protein