[The influence of smoking on the metalloproteinase 1 (MMP-1) concentration in serum in the group of patients with chronic obstructive pulmonary disease].
The aim of the study was to assess the influence of smoking on the metalloproteinase 1 (MMP-1) concentration in serum in the group of patients with chronic obstructive pulmonary disease (COPD). The study comprised 26 patients with COPD. The control group was created of 15 healthy non-smoking subjects. In the both group spirometry test was performed. The concentration of MMP-1, C-reactive protein, OB level was estimated in serum. Significant differences were noticed in the MMP-1 concentration in serum between groups (p=0.013). Significantly higher OB level (p=0.011) and C-reactive protein concentration (p=0.03) was found in the COPD group. In this same group positive correlation between MMP-1 concentration in serum and the packyears was noticed (r=0.50). No significant correlation was found between inflammatory indicators and the number of packyears. No significant correlation was noticed between MMP-1 level and FEV1 in COPD group. The analysis of the data shows significant influence of smoking on the increase of MMP-1 concentration in serum in the group of COPD patients.
Rozyńska
Renata
R
Klinika Chorób Wewnetrznych Pneumonologii i Alergologii Centralnego Szpitala Klinicznego Ministerstwa Obrony Narodowej Wojskowy Instytut Medyczny, Warszawa. r.rozynska@aster.pl
Jahnz-Rózyk
Karina
K
Targowski
Tomasz
T
Grabowska
Patrycja
P
From
Sławomir
S
D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood*; D012907:Smoking / Q000009:adverse effects*
D020781:Matrix Metalloproteinase 1