[Correlation between integrin subunits alpha5 and beta1 expressions in prostate cancer and its clinical implication].
OBJECTIVE
To explore the correlation between the expression of integrin subunits alpha5 and beta1 in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage.


METHODS
Expressions of integrin subunits alpha5 and beta1 were examined in 30 cases of PCa and 30 cases of normal prostatic tissues by immunohistochemical assay.


RESULTS
Expressions of integrin subunits alpha5 and beta1 in PCa were lower than those in normal prostatic tissues (P <0.05) respectively.


CONCLUSIONS
Compared with normal prostatic tissues, expressions of integrin subunits alpha5 and beta1 in PCa were rather weaker or even faded. Expressions of integrin subunits alpha5 and beta1 revealed an positive correlation with tumor's Gleason grade and negative with clinical TNM stage. The results indicate that integrin subunits alpha5 and beta1 have potential values in the diagnosis and are predictable indices in the proliferation of PCa.
Chen
Hai-Jiao
HJ
Department of Urology, Zhongshan Hospital, School of Medicine, Fudan University, Shanghai 200032, China.
Wang
Hao
H
Zhang
Li
L
Zhang
Yong-Kang
YK
Wang
Guo-Min
GM
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D006801:Humans; D039482:Integrin alpha5 / Q000096:biosynthesis*; D039081:Integrin alpha5beta1 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009367:Neoplasm Staging; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D039482:Integrin alpha5; D039081:Integrin alpha5beta1