title: Accumulation of celecoxib with a 7-fold higher drug exposure in individuals homozygous for CYP2C9*3.
authors.forename: Mia Sandberg
authors.initials: MS
authors.lastname: Lundblad
authors.forename: Staffan
authors.initials: S
authors.lastname: Ohlsson
authors.forename: Peter
authors.initials: P
authors.lastname: Johansson
authors.forename: Pierre
authors.initials: P
authors.lastname: Lafolie
authors.forename: Erik
authors.initials: E
authors.lastname: Eliasson
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000493:pharmacokinetics*; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000493:pharmacokinetics*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; D000068579:Celecoxib