Nitrosative/oxidative modifications and ageing.
We present here a brief description of the relationships among metals, nitric oxide metabolism, and ageing. In particular, we will discuss the interactions occurring between redox (copper, iron) and non-redox (zinc) metals and nitric oxide, the metal- and nitric oxide-catalyzed formation of thiol adducts (nitrosothiols, mixed disulphides) and the possible involvement of these species in the ageing process.
Musci
Giovanni
G
Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, University of Messina, Italy.
Persichini
Tiziana
T
Casadei
Manuela
M
Mazzone
Valeria
V
Venturini
Giorgio
G
Polticelli
Fabio
F
Colasanti
Marco
M
D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D019216:Metals, Heavy / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009603:Nitroso Compounds / Q000378:metabolism; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000378:metabolism
D019216:Metals, Heavy; D009603:Nitroso Compounds; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D005978:Glutathione