Polyarthritis and familial pulmonary fibrosis in a child.
A 7-year-old girl presented with seropositive polyarthritis, autoimmune thyroiditis, and pulmonary fibrosis. Several family members had complex autoimmune disorders and pulmonary fibrosis, and the pedigree was consistent with autosomal dominant inheritance. The possible links between polyarthritis and familial pulmonary fibrosis are discussed, as well as the therapeutic challenges raised by this extraordinarily rare combination.
Launay
Franck
F
Pediatric Orthopedic Surgery Department, la Timone Teaching Hospital, boulevard Jean Moulin, 13005 Marseille, France.
Guillaume
Jean-Marc
JM
Gennari
Jean-Marie
JM
Gonzales
Jean-François
JF
Bollini
Gérard
G
Koné Paut
Isabelle
I
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000150:complications* / Q000235:genetics / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D010375:Pedigree; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000235:genetics / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000235:genetics / Q000276:immunology; D014222:Triamcinolone Acetonide / Q000031:analogs & derivatives / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide