title: Synthesis and antimicrobial activity of new (E)-4-[piperidino (4'-methylpiperidino-, morpholino-) N-alkoxy]stilbenes.
abstract: The synthesis of twenty-one new (E)-4-[piperidino-(4;-methylpiperidino-, morpholino-)N-alkoxy] stilbenes is reported. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria, and fungi. In particular, compounds 3b, 3c, 3f, 3g, 3h, 3k, 3l showed good antibacterial activity against Staphylococcus aureus and 3h, 3k, 3m, 3n also against Bacillus subtilis, as well as 3h, 3n also against Streptococcus faecalis.
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland. wyrzyk@amu.edu.pl
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Wyrzykiewicz
authors.forename: Monika
authors.initials: M
authors.lastname: Wendzonka
authors.forename: Bogdan
authors.initials: B
authors.lastname: Kedzia
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D004121:Dimethyl Sulfoxide; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D009025:Morpholines; D013267:Stilbenes; D004121:Dimethyl Sulfoxide