Outcome and effect of pregnancy in myotonic dystrophy type 2.
The authors reviewed the obstetric histories of 42 women of 37 families with myotonic dystrophy type 2 (DM2). Nine women (21%) had the first symptoms during pregnancy and worsening in subsequent pregnancies. Of 96 pregnancies, 13% ended as early and 4% as late miscarriages. Preterm labor occurred in 50% of pregnancies resulting in 27% preterm deliveries in women with overt DM2 in pregnancy. There was no evidence of a congenital DM2.
Rudnik-Schöneborn
S
S
Institute for Human Genetics, RWTH Aachen University, Aachen, Germany. srudnik-schoeneborn@ukaachen.de
Schneider-Gold
C
C
Raabe
U
U
Kress
W
W
Zerres
K
K
Schoser
B G H
BG
D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D009154:Mutation; D009223:Myotonic Dystrophy / Q000235:genetics / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011256:Pregnancy Outcome; D016601:RNA-Binding Proteins / Q000235:genetics
C433227:CNBP protein, human; D016601:RNA-Binding Proteins