Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis.
This case report describes congenital nephrotic syndrome in a 2-month-old girl associated with cytomegalovirus infection. Histological examination on renal biopsy showed diffuse mesangial sclerosis and cytomegalic inclusion bodies in the tubular cells and in some glomeruli. Cytomegalovirus (CMV) polymerase chain reaction (PCR) titer in serum was high. Remission of pulmonary and renal symptoms was achieved with ganciclovir in 3 weeks. No recurrence of proteinuria was observed during the follow-up period of 14 months. These finding suggested a causal relationship between congenital nephrotic syndrome and cytomegalovirus infection.
Besbas
Nesrin
N
Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Bayrakci
Umut Selda
US
Kale
Gulsev
G
Cengiz
Ali Bulent
AB
Akcoren
Zuhal
Z
Akinci
Devrim
D
Kilic
Ilke
I
Bakkaloglu
Aysin
A
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D005920:Glomerular Mesangium / Q000473:pathology* / Q000821:virology; D006801:Humans; D007181:Inclusion Bodies, Viral; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D009404:Nephrotic Syndrome / Q000151:congenital* / Q000473:pathology / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012598:Sclerosis
D000998:Antiviral Agents; D015774:Ganciclovir