title: Transmural distribution of myocardial blood perfusion and phasic coronary blood flow pattern in a canine model of acute ischemia.
abstract: BACKGROUND
  Although several investigators have analyzed coronary artery blood flow under various conditions, almost all these studies have measured only some branches of the left anterior descending (LAD), left circumflex (LCX), or right coronary (RCA) artery.
  
  
  METHODS
  In a canine model of acute ischemia (n = 5), we simultaneously assessed (a) regional myocardial blood perfusion using microspheres and (b) phasic coronary blood flow patterns as measured by three epicardial flow probes placed around the LAD, LCX, and RCA.
  
  
  RESULTS
  The results from this study indicated that the LAD supplies blood to the epicardial (r = 0.687, p<0.0001), midwall (r = 0.556, p = 0.0021), and endocardial layers (r = 0.666, p = 0.0001) of the LAD area; the LCX supplies the midwall (r = 0.514, p = 0.0051) and endocardial layer (r = 0.621, p = 0.0004) of the LCX area, antero-lateral papillary muscle (r = 0.548, p = 0.0025), and postero-medial papillary muscle (r = 0.641, p = 0.0002), especially during the diastolic phase; and the RCA supplies the right ventricular apex (r=0.559, p=0.0020), left atrium (r = 0.618, p = 0.0005), right atrium (r = 0.471, p = 0.0114), and postero-medial papillary muscle (r = 0.486, p = 0.0088), especially during the systolic phase.
  
  
  CONCLUSIONS
  These results are potentially relevant to understanding the physiology of myocardial blood perfusion and to improving treatment of acute myocardial ischemia and infarction.
authors.affiliation: Department of Biomedical Engineering (ND20), Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Keiji
authors.initials: K
authors.lastname: Kamohara
authors.forename: Soren
authors.initials: S
authors.lastname: Schenk
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kopcak
authors.forename: Raymond
authors.initials: R
authors.lastname: Dessoffy
authors.forename: Paul
authors.initials: P
authors.lastname: Schoenhagen
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004285:Dogs; D016014:Linear Models; D008833:Microcirculation; D008863:Microspheres; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging; D014463:Ultrasonography