Application of UL144 molecular typing to determine epidemiology of cytomegalovirus infections in preterm infants.
Sequence analysis of the UL144 gene of human cytomegalovirus (CMV) was used to investigate the epidemiology of CMV infections in preterm infants. Nosocomial transmission of CMV from congenitally infected infant to preterm twins was excluded based on distinct molecular profiles of CMV strains. Indistinguishable molecular profiles between strains from the mother and the infant indicated postnatal acquisition of CMV through breastfeeding.
Stranska
R
R
Department of Virology, Eijkman-Winkler Centre, Utrecht, The Netherlands. ruzena.stranska@umassmed.edu
Schuurman
R
R
Toet
M
M
Verboon-Maciolek
M
M
de Vries
L S
LS
van Loon
A M
AM
D001483:Base Sequence; D001942:Breast Feeding / Q000009:adverse effects; D003428:Cross Infection / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D003587:Cytomegalovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D017931:DNA Primers / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005814:Genes, Viral; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008562:Membrane Glycoproteins / Q000235:genetics*; D008895:Milk, Human / Q000821:virology; D017720:Molecular Epidemiology; D009426:Netherlands / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics*
D017931:DNA Primers; D004279:DNA, Viral; D008562:Membrane Glycoproteins; C119624:UL144 ORF protein, Human herpesvirus 5; D014764:Viral Proteins