[Cryptococcal meningo-encephalitis in an apparently immunocompetent patient].
BACKGROUND
Cryptococcal meningo-encephalitis is a rare disease occurring more frequently in immunocompromised hosts.


METHODS
We report the case of an apparently immunocompetent patient who developed a recurrent neurological deficit with lymphocytic meningitis. The time from the first symptoms to diagnosis was 8 months. We noted mild CD4+ lymphocytopenia (500 cells/mm3) without HIV infection. CD4+ lymphocytes were not reactive for a panel of antigens.


CONCLUSIONS
This case illustrates the usefulness of cerebrospinal fluid Cryptococcus Neoformans antigen test in patients with an unexplained neurological syndrome with a lymphocytic meningitis together with quantification of circulating lymphocytes clusters and analyse of their function in opportunistic infections.
Bretaudeau
K
K
Service de Neurologie, CH de Versailles, Hôpital A. Mignot, Le Chesnay.
Eloy
O
O
Richer
A
A
Bruneel
F
F
Scott-Algara
D
D
Lortholary
O
O
Pico
F
F
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000097:blood; D001921:Brain / Q000473:pathology; D018791:CD4 Lymphocyte Count; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D004359:Drug Therapy, Combination; D004660:Encephalitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D008279:Magnetic Resonance Imaging; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D016896:Treatment Outcome
D000935:Antifungal Agents; D000946:Antigens, Fungal; D000666:Amphotericin B; D005437:Flucytosine