title: Antimicrobial activity and cytotoxicity of bis(indole) alkaloids from the sponge Spongosorites sp.
abstract: Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited more potent antibacterial activity than those of the topsentin class. Deoxytopsentin (1) and hamacanthin A (5) also exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus, with MIC values of less than 12.5 microg/ml. In the antifungal activity test, hamacanthins, especially hamacanthin A (5), showed potent inhibitory activity against medically important pathogenic fungi. In contrast, all of the topsentins (1-4) were inactive against fungal growth. These compounds (1-9) also exhibited moderate cytotoxicity against cancer cell lines at concentrations between 1.1 and >20 microg/ml.
authors.affiliation: Seoul National University, School of Agricultural Biotechnology, Korea. ohkibong@snu.ac.kr
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Woongchon
authors.initials: W
authors.lastname: Mar
authors.forename: Sanghee
authors.initials: S
authors.lastname: Kim
authors.forename: Ji-Yun
authors.initials: JY
authors.lastname: Kim
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Lee
authors.forename: Jae-Gyu
authors.initials: JG
authors.lastname: Kim
authors.forename: Daehyun
authors.initials: D
authors.lastname: Shin
authors.forename: Chung J
authors.initials: CJ
authors.lastname: Sim
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005658:Fungi; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007211:Indoles