Polar steroidal compounds from the far eastern starfish Henricia leviuscula.
Five new polar steroids, polyhydroxysterols 2-5 and the glycoside leviusculoside J (7), were isolated, along with the previously known compounds 1, 6, 8, and 9, from the alcoholic extract of the Far Eastern starfish Henricia leviuscula. The structures of novel compounds were elucidated by interpretation of spectral data (mainly 2D-NMR), and the stereochemistry of chiral centers in the side chain of sterols 2 and 3 was determined by using J-based configuration analysis and the modified Mosher's method. Steroids 1, 3, 6, 7, and 9 showed moderate hemolytic activity in the mouse erythrocytes assay.
Ivanchina
Natalia V
NV
Pacific Institute of Bioorganic Chemistry of the Far East Branch of the Russian Academy of Science, Vladivostok-22, Russian Federation.
Kicha
Alla A
AA
Kalinovsky
Anatoly I
AI
Dmitrenok
Pavel S
PS
Dmitrenok
Andrey S
AS
Chaikina
Elena L
EL
Stonik
Valentin A
VA
Gavagnin
Margherita
M
Cimino
Guido
G
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006914:Hydroxysteroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009792:Oceans and Seas; D013215:Starfish / Q000737:chemistry*
D006914:Hydroxysteroids