Unusual amino acids: synthesis and introduction into naturally occurring peptides and biologically active analogues.
This review covers our recent advances in the synthesis of unusual amino acids in optically pure form, and their introduction into naturally occurring peptides with specific biological properties, or into modified bioactive peptides, aiming to obtain analogues displaying enhanced performances in term of activity, bioavailability and resistance to enzymatic hydrolysis.
Cardillo
G
G
Dip. Chimica G. Ciamician, Università degli Studi di Bologna, Via Selmi 2, 40126 Bologna, Italy. cardillo@ciam.unibo.it
Gentilucci
L
L
Tolomelli
A
A
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis*; D001388:Aziridines / Q000138:chemical synthesis / Q000494:pharmacology; D001682:Biological Availability; D047630:Depsipeptides / Q000138:chemical synthesis / Q000494:pharmacology; D004723:Endorphins / Q000138:chemical synthesis / Q000494:pharmacology; D018716:Molecular Mimicry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D015202:Protein Engineering; D013237:Stereoisomerism; D013379:Substrate Specificity
D000596:Amino Acids; D001388:Aziridines; D047630:Depsipeptides; D004723:Endorphins; D010455:Peptides; C056790:katanosin B