title: Antiplatelet prenylflavonoids from Artocarpus communis.
abstract: Four flavonoids, dihydroartomunoxanthone (1), artomunoisoxanthone (2), cyclocomunomethonol (3) and artomunoflavanone (4), together with three known compounds, artochamins B (5), D and artocommunol CC (6) were isolated from the cortex of the roots of Artocarpus communis. The structures of 1-4 were determined by spectroscopic methods. The antiplatelet effects of the flavonoids, 1-3, 5 and 6 on human platelet-rich plasma (PRP) were evaluated. Of the compounds tested in human PRP, compounds 1, 5 and 6 showed significant inhibition of secondary aggregation induced by adrenaline. It is concluded that the antiplatelet effect of 1, 5 and 6 is mainly owing to an inhibitory effect on thromboxane formation.
authors.affiliation: Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Weng
authors.forename: Sheng-Ching
authors.initials: SC
authors.lastname: Chan
authors.forename: Yi-Huang
authors.initials: YH
authors.lastname: Lu
authors.forename: Hsien-Cheng
authors.initials: HC
authors.lastname: Lin
authors.forename: Horng-Huey
authors.initials: HH
authors.lastname: Ko
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Lin
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
chemical_list: D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors