Frequency of CCR5delta32 in Brazilian populations.
A sample of 103 randomly chosen healthy individuals from Alegrete, RS, Brazil, was tested for the CCR5delta32 allele, which is known to influence susceptibility to HIV-1 infection. The CCR5delta32 allele was identified by PCR amplification using specific primers flanking the region of deletion, followed by electrophoresis on a 3% agarose gel. The data obtained were compared to those reported for other populations and interpreted in terms of Brazilian history. The individuals studied came from a highly admixed population. Most of them were identified as white (N = 59), while blacks and browns (mulattoes) were N = 13 and N = 31, respectively. The observed frequencies, considering the white, black and brown samples (6.8, 3.8, and 6.4%, respectively), suggest an important European parental contribution, even in populations identified as black and brown. However, in Brazil as a whole, this allele shows gradients indicating a relatively good correlation with the classification based on skin color and other physical traits, used here to define major Brazilian population groups.
Vargas
A E
AE
Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Marrero
A R
AR
Salzano
F M
FM
Bortolini
M C
MC
Chies
J A B
JA
D000483:Alleles; D044383:Black People / Q000235:genetics; D001938:Brazil / Q000208:ethnology; D004587:Electrophoresis, Agar Gel; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population / Q000379:methods; D005838:Genotype; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D016133:Polymerase Chain Reaction; D019713:Receptors, CCR5 / Q000235:genetics*; D044465:White People / Q000235:genetics
D019713:Receptors, CCR5