title: Patterns of impairment in autobiographical memory in the degenerative dementias constrain models of memory.
abstract: Detailed study of the autobiographical memory (ABM) impairments seen in different forms of degenerative dementia, in particular Alzheimer's disease (AD) and semantic dementia (SD) can inform neuropsychological models of memory. A modified ABM questionnaire which allowed more detailed analysis of episodic and semantic ABM was used to study the pattern of deficits in patients with minimal to mild Alzheimer's disease (AD) and in two patients with mild and moderate semantic dementia (SD). The questionnaire tested both cued and free recall. A group of healthy elderly was also tested. AD patients differed from controls in all measures. There was no clear temporal gradient for episodic ABM, but a modest gradient was observed for semantic ABM. The mild SD patient performed at control level for episodic ABM but showed a deficit within the range of the AD patients for semantic ABM except for the most recent life period. In contrast the moderate SD patient was impaired within the range of the AD patients for both episodic and semantic ABM. The evidence for differential impairment of episodic and semantic ABM retrieval in AD and SD is interpreted as supporting the multiple trace model of memory.
authors.affiliation: Neurology Department and Neuropsychological Rehabilitation Unit, Saint Luc Hospital, University of Louvain, Brussels, Belgium.
authors.forename: Adrian
authors.initials: A
authors.lastname: Ivanoiu
authors.forename: Janine M
authors.initials: JM
authors.lastname: Cooper
authors.forename: Michael F
authors.initials: MF
authors.lastname: Shanks
authors.forename: Annalena
authors.initials: A
authors.lastname: Venneri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology; D000704:Analysis of Variance; D003704:Dementia / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000145:classification* / Q000503:physiopathology*; D008960:Models, Psychological; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires