title: Fluoride concentration in saliva after consumption of a dinner meal prepared with fluoridated salt.
abstract: The aim was to determine the fluoride concentration in saliva after intake of a dinner meal prepared with fluoridated salt. The investigation had a randomized cross-over design, and 10 healthy adolescents with natural fluoride content (1.06 ppm) in their drinking water participated after informed consent. After a run-in week, the subjects were served a standardized dinner of spaghetti with minced meat sauce prepared with either fluoridated salt (test arm) or non-fluoridated salt (control arm). The fluoride concentration of the test salt was 250 ppm. Samples of stimulated whole saliva was collected at baseline, directly after eating (0 min) and then after 10, 30 and 180 min. After a 1-week wash-out period, the experimental procedure was repeated with the opposite salt. Fluoride concentration in saliva was measured with a fluoride-specific electrode and the post-ingestion levels were compared with baseline using repeated-measures ANOVA. The mean baseline concentrations were 10.9 and 8.0 microg/l in the test and control arms, respectively. Immediately after the intake, the mean fluoride values increased significantly to 81.6 microg/l in the test arm and to 31.5 microg/l in the control arm (p<0.05). The fluoride levels remained elevated (p<0.05) for 30 min after ingestion of the test meal but not following the control meal. In conclusion, consumption of a dinner meal prepared with fluoridated salt increased the salivary fluoride levels for about 30 min.
authors.affiliation: Department of Odontology, Pediatric Dentistry, Faculty of Medicine, Umeå University, Umeå, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Hedman
authors.forename: R
authors.initials: R
authors.lastname: Sjöman
authors.forename: I
authors.initials: I
authors.lastname: Sjöström
authors.forename: S
authors.initials: S
authors.lastname: Twetman
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002648:Child; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D006801:Humans; D017736:Ion-Selective Electrodes; D008297:Male; D008657:Metabolic Clearance Rate; D017680:Potassium Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D002327:Cariostatic Agents; D017680:Potassium Compounds; D017673:Sodium Chloride, Dietary; C033320:potassium fluoride; D005459:Fluorides