Risk of T2DM and impaired fasting glucose among PCOS subjects: results of an 8-year follow-up.
Women with polycystic ovary syndrome (PCOS) often develop type 2 diabetes mellitus (T2DM). To determine the magnitude of risk of developing T2DM among women with PCOS, development of T2DM was prospectively assessed among women who had T2DM (n = 97) and controls (n = 95) using Kaplan-Meier survival analysis and Cox proportional hazards modeling. The women with T2DM had higher baseline weight (body mass index, P < 0.01) and lower insulin sensitivity (homeostasis assessment model of insulin resistance, P < 0.01). The 8-year incidence rate among cases and controls was 13.4% and 5.8%, respectively (relative risk = 2.3). Obese cases had a fivefold risk of T2DM developing (P < 0.01) compared with age-adjusted obese controls, indicating significant interaction between PCOS and obesity to effect T2DM risk.
Boudreaux
Monique Y
MY
Talbott
Evelyn O
EO
Kip
Kevin E
KE
Brooks
Maria M
MM
Witchel
Selma F
SF
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000401:mortality; D012016:Reference Values; D012307:Risk Factors; D012907:Smoking; D016019:Survival Analysis
D001786:Blood Glucose