Intracystic papilloma in the breast of a male given long-term phenothiazine therapy: a case report.
We experienced a very rare case of intracystic papilloma in a 57-year-old man who came to our hospital complaining of a left subareolar mass and nipple discharge. The patient had a history of chronic schizophrenia, necessitating long-term treatment with phenothiazines. His serum prolactin levels were elevated. Mammography demonstrated a well defined mass with microcalcifications. Ultrasonography revealed a cyst with an intracystic component. The inner lesion of the mass enhanced on contrast-enhanced computed tomography. The carcinoembryonic antigen concentration of the cyst fluid was 400 ng/mL and no malignant cells were found by aspiration biopsy cytology. Excisional biopsy was performed under local anesthesia. Pathological examination revealed the intracystic component to be intracystic papilloma. There are ten reports of male intracystic papilloma including ours. We report the second case of a patient given long-term phenothiazine therapy, which is known to increase serum prolactin levels.
Yamamoto
Hitoshi
H
Department of Surgery, Minoh City Hospital, 5-7-1, Kayano, Osaka 562-8562, Japan.
Okada
Yoshikazu
Y
Taniguchi
Haruo
H
Handa
Rio
R
Naoi
Yasuto
Y
Oshima
Satoshi
S
Kato
Takeshi
T
Tsujie
Masaki
M
Iijima
Shohei
S
Kurokawa
Eiji
E
Kikkawa
Nobuteru
N
Kadone
Kensuke
K
D014150:Antipsychotic Agents / Q000009:adverse effects*; D047688:Breast Cyst / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D018567:Breast Neoplasms, Male / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008327:Mammography; D008875:Middle Aged; D010212:Papilloma / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D010640:Phenothiazines / Q000009:adverse effects*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents; D002272:Carcinoembryonic Antigen; D010640:Phenothiazines