Treatment of asthma with antileukotrienes: first line or last resort therapy?
Twenty five years after the structure elucidation of slow reacting substance of anaphylaxis, antileukotrienes are established as a new therapeutic modality in asthma. The chapter reviews the biochemistry and pharmacology of leukotrienes and antileukotrienes with particular focus on the different usage of antileukotrienes for treatment of asthma and rhinitis in Europe and the US. Further research needs and new areas for leukotriene involvement in respiratory diseases are also discussed.
Dahlén
Sven-Erik
SE
Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden. se.dahlen@imm.ki.se
D000085:Acetates / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D002986:Clinical Trials as Topic; D003521:Cyclopropanes; D006801:Humans; D006918:Hydroxyurea / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D020024:Leukotriene Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D017997:Leukotriene C4 / Q000037:antagonists & inhibitors / Q000378:metabolism; D017998:Leukotriene D4 / Q000037:antagonists & inhibitors / Q000378:metabolism; D017999:Leukotriene E4 / Q000037:antagonists & inhibitors / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use; D018077:Receptors, Leukotriene / Q000378:metabolism; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism; D012220:Rhinitis / Q000188:drug therapy / Q000378:metabolism; D013440:Sulfides
D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D011804:Quinolines; D018077:Receptors, Leukotriene; D013440:Sulfides; D017997:Leukotriene C4; D017998:Leukotriene D4; D017999:Leukotriene E4; C083169:leukotriene D4 receptor; C093875:montelukast; C063449:zileuton; D006918:Hydroxyurea