title: [Clinical significance of explore the diagnostic and prognostic value of plasma saliva acid (SA) level for laryngeal carcinoma].
abstract: OBJECTIVE
  To explore the diagnostic and prognostic value of plasma saliva acid (SA) level for laryngeal carcinoma.
  
  
  METHODS
  The plasma level of SA was measured in healthy individuals, cases with laryngeal benign diseases and cases with laryngeal carcinoma of different clinical stage. The plasma SA level in patients with laryngeal carcinoma was measured periodically at 2 weeks, 4 weeks and 1 year after operation.
  
  
  RESULTS
  The plasma SA level was significantly higher in patients with laryngeal carcinoma and 2 weeks postoperatively than that in healthy individuals and patients with benign diseases(P <0.01), there was no significant difference in plasma SA level between healthy individuals and patients with benign diseases(P >0.05). It decreased gradually if there was no recurrence and metastasis in patients with laryngeal carcinoma between 4 weeks and 1 year after operation, but it maintained at high level if there was recurrence or metastasis.
  
  
  CONCLUSIONS
  The detection of plasma SA level periodically has an important referenced value in diagnosis and prognosis for laryngeal carcinoma.
authors.affiliation: Department of Otolaryngology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China. zhouwennn@21cn.com
authors.forename: Wen
authors.initials: W
authors.lastname: Zhou
authors.forename: Jiquan
authors.initials: J
authors.lastname: Tan
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D011379:Prognosis
chemical_list: D019158:N-Acetylneuraminic Acid