Antioxidant activity of beta-blockers: an effect mediated by scavenging reactive oxygen and nitrogen species?
The therapeutic effects of beta-blockers are normally explained by their capacity to block the beta-adrenoceptors, however, some of the beneficial cardiovascular effects shown by this group of compounds have already been associated with the antioxidant properties that some of them seem to possess. The beta-blockers atenolol, labetalol, metoprolol, pindolol, propranolol, sotalol, timolol, and carvedilol were tested for their putative scavenging activity for ROS (O(2)(-), H(2)O(2), HO(.), HOCl, and ROO(.)) and RNS ((.)NO and ONOO(-)). Some of the studied compounds are effective ROS and/or RNS scavengers, these effects being possibly useful in preventing oxidative damage verified in hypertension as well as in other cardiovascular diseases that frequently emerge in association with oxidative stress.
Gomes
Ana
A
REQUIMTE, Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Portugal.
Costa
David
D
Lima
José L F C
JL
Fernandes
Eduarda
E
D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D030421:Peroxynitrous Acid; D026361:Reactive Nitrogen Species / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry
D000319:Adrenergic beta-Antagonists; D000975:Antioxidants; D016166:Free Radical Scavengers; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D006861:Hydrogen Peroxide