title: Successful alpha-1 receptor blockade therapy in a toddler with infrequent and difficult voiding.
abstract: A 3-year-old neurologically intact and behaviorally normal boy developed infrequent and difficult voiding subsequent to a soft tissue injury to the glans penis. Symptoms persisted for at least 9 months, and the course was complicated by diagnostic imaging evidence of a "markedly distended" bladder and a voiding diary that suggested elevated bladder volumes. Treatment with an alpha-1 receptor blocker normalized voiding within 24 hours. Discontinuation of the medication after 2 weeks resulted in recurrence of symptoms within 48 hours. Readministration of the medication resulted in prompt resolution of symptoms.
authors.affiliation: Pediatric Urology, University of Oklahoma, USA.
authors.forename: William Lane M
authors.initials: WL
authors.lastname: Robson
authors.forename: Alexander K C
authors.initials: AK
authors.lastname: Leung
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D002675:Child, Preschool; D017292:Doxazosin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010413:Penis / Q000293:injuries; D016055:Urinary Retention / Q000188:drug therapy* / Q000209:etiology
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D017292:Doxazosin