title: Induction of spermatogenesis in azoospermic men after varicocelectomy repair: an update.
abstract: OBJECTIVE
  To assess the treatment outcome after varicocele repair in azoospermic men and to correlate this outcome with the testicular histology patterns.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Academic medical centers.
  
  
  METHODS
  Medical records of 27 azoospermic men, who underwent testis biopsy and microsurgical repair of clinical varicocele between July 1999 and May 2004, were reviewed.
  
  
  METHODS
  Twenty-seven azoospermic men underwent testis biopsy and microsurgical repair of clinical varicocele. All patients had at least two semen analyses showing azoospermia taken before the surgery and two semen analyses postoperatively.
  
  
  METHODS
  Semen analysis after varicocelectomy.
  
  
  RESULTS
  Hypospermatogenesis was identified in 9, maturation arrest in 8, and germ cell aplasia in 10 men. Induction of spermatogenesis was achieved in nine men (33.3%). Of these, four had germ cell aplasia, three had maturation arrest, and two had hypospermatogenesis. The improvement in sperm concentration and motility ranged from 1.2 x 10(6)/mL to 8.9 x 10(6)/mL, and from 24% to 75.7%, respectively. Of these nine patients with improvement in semen quality, five relapsed into azoospermia 6 months after the recovery of spermatogenesis (four germ cell aplasia and one maturation arrest). One patient with maturation arrest established pregnancy.
  
  
  CONCLUSIONS
  Azoospermic patients may have an improvement in semen quality after varicocelectomy. Semen samples may be cryopreserved after an initial improvement after varicocelectomy.
authors.affiliation: Divisão de Clínica Urológica, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Fabio@conception-rs.combr
authors.forename: Fábio Firmbach
authors.initials: FF
authors.lastname: Pasqualotto
authors.forename: Bernardo Passos
authors.initials: BP
authors.lastname: Sobreiro
authors.forename: Jorge
authors.initials: J
authors.lastname: Hallak
authors.forename: Eleonora Bedin
authors.initials: EB
authors.lastname: Pasqualotto
authors.forename: Antônio Marmo
authors.initials: AM
authors.lastname: Lucon
mesh_terms: D000328:Adult; D001284:Atrophy; D016922:Cellular Senescence; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011184:Postoperative Period; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012008:Recurrence; D013076:Sperm Count; D013081:Sperm Motility; D013091:Spermatogenesis; D013094:Spermatozoa / Q000648:ultrastructure; D013737:Testis / Q000473:pathology; D014646:Varicocele / Q000150:complications / Q000601:surgery*
chemical_list: D005640:Follicle Stimulating Hormone