Fatal haemoptysis in a case of lymphomatoid granulomatosis treated with rituximab.
Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin. This report describes the case of a 33-yr-old female with an aggressive form of lymphoid granulomatosis treated with an anti-CD20 antibody. Dramatic radiological improvement was seen at the fourth week. However, the patient died at home 1 month after the last rituximab administration from a massive haemoptysis.
Jaffre
S
S
Clinique pneumologique and Service de radiologie, CHU Rouen, Hôpital Guillaume et René Laennec, Boulevard Jacques Monod, 44093 Nantes Cedex 1, France. sandrine.jaffre@chu-nantes.fr
Jardin
F
F
Dominique
S
S
Duet
E
E
Hubscher
Ph
P
Genevois
A
A
Corne
F
F
Bota
S
S
Nouvet
G
G
Thiberville
L
L
D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D017809:Fatal Outcome; D005260:Female; D006469:Hemoptysis / Q000209:etiology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008230:Lymphomatoid Granulomatosis / Q000150:complications* / Q000188:drug therapy*; D000069283:Rituximab
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab