title: Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion.
abstract: BACKGROUND
  Verrucous carcinoma is a rare condition. A defined disease of the oral cavity, larynx, esophagus, skin, vulva, vagina and cervix. But a verrucous carcinoma arising from the endometrium without evidence of cervical malignancy or endometrial adenocarcinoma is extremely rare.
  
  
  METHODS
  A 67-year-old G2P2 menopausal patient that was referred for consultation 1 year after presenting with vaginal bleeding to her gynecologist who subsequently underwent several endometrial biopsies where the pathological findings were repetitively similar: papillary squamous proliferation, cytologically bland with low mitotic activity but extensive proliferation. A hysterectomy with bilateral salpingo-oophorectomy was performed. The final histologic examination revealed a squamous cell carcinoma of endometrium, verrucous and well differentiated, and there was no cervical invasion identified.
  
  
  CONCLUSIONS
  This is a rare form of endometrial cancer with apparent favorable prognosis that must be considered when squamous cells are identified on endometrial samplings.
authors.affiliation: University of Massachusetts Medical School, Department of Obstetrics and Gynecology, 119 Belmont Street J4, Worcester, MA 01605, USA. illanesd@ummhc.org
authors.forename: Diego
authors.initials: D
authors.lastname: Illanes
authors.forename: Jerry
authors.initials: J
authors.lastname: Broman
authors.forename: Bruce
authors.initials: B
authors.lastname: Meyer
authors.forename: Daniel
authors.initials: D
authors.lastname: Kredentser
authors.forename: Timothy
authors.initials: T
authors.lastname: McElrath
authors.forename: Patrick
authors.initials: P
authors.lastname: Timmins
mesh_terms: D000368:Aged; D018289:Carcinoma, Verrucous / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans