Lipoprotein(a) and lipid profile in patients with atrial fibrillation.
BACKGROUND
Atrial fibrillation (AF) is well-known risk factor for cardiac embolic events, especially cerebrovascular events. The association between AF and lipid markers was evaluated. Among all these markers, lipoprotein(a), or (Lp(a), was also investigated. The aim of our study was to evaluate the characteristics of the lipid profile in patients with AF, focusing on Lp(a) levels.


METHODS
One hundred and one patients with AF were included in the study group. We used 101 patients without AF, matched by sex and age with the study group, as the control group. Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, Lp(a), and the LDL/HDL, COL/LDL, and COL/HDL indexes were measured. The study was performed in Spain with a Caucasian population.


RESULTS
Among all the variables included there was statistical difference only between groups in the COL/HDL index, showing a greater value in the group of patients with AF. No difference was found in Lp(a) levels between the groups.


CONCLUSIONS
Although some studies have tried to show a possible relationship between AF and high Lp(a) levels, we found no such relationship in our study, although ethnic differences could explain, at least in part, these results in our patients when compared with other ethnic populations.
Díaz-Peromingo
José Antonio
JA
Department of Internal Medicine, Hospital Da Barbanza, Riveira, Spain. jadiazperomingo@mundo-r.com
Albán-Salgado
Ana
A
García-Suárez
Florinda
F
Sánchez-Leira
Joaquín
J
Saborido-Froján
Juan
J
Iglesias-Gallego
Marina
M
D000368:Aged; D001281:Atrial Fibrillation; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics; D017270:Lipoprotein(a) / Q000097:blood* / Q000235:genetics; D008077:Lipoproteins, LDL / Q000097:blood / Q000235:genetics; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood / Q000235:genetics; D044465:White People / Q000235:genetics
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol