title: Pituitary thyroid resistance syndrome.
abstract: Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by goiter and biochemically by elevated circulating free thyroid hormone levels in the presence of measurable serum thyroid-stimulating hormone (TSH) concentrations. About 85% of patients with RTH harbor mutations in thyroid hormone receptor [beta] (TR[beta]). Even rarer is pituitary thyroid resistance syndrome. We report a case of a 35-year-old man who presented with hypermetabolic symptoms with elevated levels of thyroid hormones, associated with nonsuppressed thyrotropin (TSH). When treated with anti-thyroid drugs, his thyroid hormone levels normalized and TSH increased, suggesting thyroid resistance at the pituitary level.
authors.affiliation: Endocrine Unit, Department of Medicine, Faculty of Medicine Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur.
authors.forename: S
authors.initials: S
authors.lastname: Norlela
authors.forename: K
authors.initials: K
authors.lastname: Nor Azmi
authors.forename: B A K
authors.initials: BA
authors.lastname: Khalid
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D010900:Pituitary Diseases / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D018382:Thyroid Hormone Resistance Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy