title: TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer.
abstract: The study investigated an association between the germline polymorphism at TP53 codon 72 and the development of papillary thyroid cancer (PTC) following exposure to radiation from the Chernobyl accident. TP53 genotype was examined in 48 pediatric/adolescent (age at diagnosis <18 years) and 68 adult post-Chernobyl patient with PTC, 53 adult patients with sporadic PTC and 313 healthy individuals from Russian-Ukrainian population. In addition, we evaluated loss of heterozygosity for TP53 and the allele expression ratio. The genotype of the patients was correlated with clinicopathological data. Arg TP53 homozygotes were found to be significantly underrepresented among adults with post-Chernobyl PTC, but not in children and adolescents when compared with sporadic PTC cases and the general population. In the tumors, cell transformation did not lead to allelic loss or biased TP53 allele expression in heterozygous individuals. None of TP53 genotypes specifically associated with tumor stage and morphology, however there were particular correlations with lymph node status in certain age groups of radiation-associated cases not seen in sporadic PTCs. The findings suggest TP53 allele combinations other than Arg/Arg may contribute to the risk of development of PTC in individuals exposed to radiation during their late childhood, adolescence or in young adulthood.
authors.affiliation: Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
authors.forename: Tatiana I
authors.initials: TI
authors.lastname: Rogounovitch
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Saenko
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Ashizawa
authors.forename: Ilya A
authors.initials: IA
authors.lastname: Sedliarou
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Namba
authors.forename: Aleksandr Yu
authors.initials: AY
authors.lastname: Abrosimov
authors.forename: Eugeny F
authors.initials: EF
authors.lastname: Lushnikov
authors.forename: Pavel O
authors.initials: PO
authors.lastname: Roumiantsev
authors.forename: Marina V
authors.initials: MV
authors.lastname: Konova
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Petoukhova
authors.forename: Irina V
authors.initials: IV
authors.lastname: Tchebotareva
authors.forename: Viktor K
authors.initials: VK
authors.lastname: Ivanov
authors.forename: Sergei Yu
authors.initials: SY
authors.lastname: Chekin
authors.forename: Tatiana I
authors.initials: TI
authors.lastname: Bogdanova
authors.forename: Mykola D
authors.initials: MD
authors.lastname: Tronko
authors.forename: Anatoly F
authors.initials: AF
authors.lastname: Tsyb
authors.forename: Gerry A
authors.initials: GA
authors.lastname: Thomas
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003062:Codon / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019656:Loss of Heterozygosity; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000235:genetics / Q000528:radiation effects; D009367:Neoplasm Staging; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000473:pathology*; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000528:radiation effects; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53