Gene expression profiling in the discovery, optimization and development of novel drugs: one universal screening platform.
With recent advances in robotics and high-content screening and analysis methods, transcriptional profiling can now be utilized as a comprehensive forward chemical genomics platform for drug discovery, lead selection and lead optimization. It can be used to define the state of a cell on the basis of gene networks, and to search for drugs that can shift cellular states in a manner predicted at the genome level to be therapeutically beneficial. The treatment of cells with compounds produces transcriptional 'fingerprints' that reveal mechanism-of-action, and enable discrimination between individual compounds based on drug behaviors important to all phases of drug discovery and development.
Bol
David
D
Avalon Pharmaceuticals, Inc., 20358 Seneca Meadows Parkway, Germantown, MD 20876, USA. dbol@avalonrx.com
Ebner
Reinhard
R
D000818:Animals; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004345:Drug Industry; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods; D006801:Humans