title: Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.
abstract: A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines. Symptoms resolved when systemic corticosteroids were administered. This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.
authors.affiliation: Department of Ophthalmology, The University of Chicago, Chicago, IL 60637, USA. rmcleod@midway.uchicago.edu
authors.forename: Rima
authors.initials: R
authors.lastname: McLeod
authors.forename: Asif Rashid
authors.initials: AR
authors.lastname: Khan
authors.forename: Gwendolyn A
authors.initials: GA
authors.lastname: Noble
authors.forename: Paul
authors.initials: P
authors.lastname: Latkany
authors.forename: Jessica
authors.initials: J
authors.lastname: Jalbrzikowski
authors.forename: Kenneth
authors.initials: K
authors.lastname: Boyer
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002825:Chorioretinitis / Q000151:congenital* / Q000188:drug therapy / Q000469:parasitology; D004342:Drug Hypersensitivity / Q000209:etiology / Q000503:physiopathology*; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000209:etiology; D005260:Female; D006801:Humans; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use; D012008:Recurrence; D012720:Severity of Illness Index; D013411:Sulfadiazine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014122:Toxoplasma / Q000187:drug effects; D014126:Toxoplasmosis, Ocular / Q000151:congenital* / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000981:Antiprotozoal Agents; D013411:Sulfadiazine; D011739:Pyrimethamine