title: Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases.
abstract: To evaluate the activity of posaconazole for treatment of zygomycosis, a disease for which therapeutic options are limited, we conducted a retrospective study including 91 patients with zygomycosis (proven zygomycosis, 69 patients; probable zygomycosis, 22 patients). Patients had infection that was refractory to prior antifungal treatment (n=81) or were intolerant of such treatment (n=10) and participated in the compassionate-use posaconazole (800 mg/day) program. The rate of success (i.e., either complete or partial response) at 12 weeks after treatment initiation was 60%, and 21% of patients had stable disease. The overall high success and survival rates reported here provide encouraging data regarding posaconazole as an alternative therapy for zygomycosis.
authors.affiliation: University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Jo-Anne H
authors.initials: JA
authors.lastname: van Burik
authors.forename: Roberta S
authors.initials: RS
authors.lastname: Hare
authors.forename: Howard F
authors.initials: HF
authors.lastname: Solomon
authors.forename: Michael L
authors.initials: ML
authors.lastname: Corrado
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016879:Salvage Therapy; D014230:Triazoles / Q000627:therapeutic use*; D020096:Zygomycosis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole