Efficacy of inactivated trivalent influenza vaccine in alleviating the febrile illness of culture-confirmed influenza in children in the 2000-2001 influenza season.
During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1%), culture positive for influenza were enrolled for analysis. The numbers of patients for A/H1N1 and A/H3N2 were insufficient for statistical analysis. For influenza B the odds ratio for vaccinated children to have a maximum fever exceeding 39.5 degrees C was 0.52 (95% CI, 0.30-0.92) Our findings suggest modest impact of influenza vaccination on limiting severity of disease symptoms.
Kamada
Makoto
M
Nagai Pediatric Clinic, 2-20 Akanechou, Takamatsu, Kagawa 760-0002, and Pediatrics and Child Health, Kurume University Medical Center, Fukuoka, Japan. makoto-kamada@hokkaido.med.or.jp
Nagai
Takao
T
Kumagai
Takuji
T
Igarashi
Masahiro
M
Ihara
Toshiaki
T
Okafuji
Teruo
T
Ochiai
Hitoshi
H
Sakiyama
Hiroshi
H
Shimomura
Kunihisa
K
Suzuki
Eitaro
E
Torigoe
Sadayoshi
S
Miyazaki
Chiaki
C
Miyata
Akiko
A
Yuri
Kenji
K
Ito
Yuhei
Y
Nakayama
Tetsuo
T
Kase
Tetsuo
T
Okuno
Yoshinobu
Y
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005334:Fever / Q000517:prevention & control; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000302:isolation & purification; D009981:Influenza B virus / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D007564:Japan / Q000453:epidemiology; D013997:Time Factors; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology
D007252:Influenza Vaccines; D015164:Vaccines, Inactivated