Antifungal activity of antimicrobial-impregnated devices.
The in-vitro and in-vivo efficacy against Candida albicans and Candida krusei of devices impregnated with chlorhexidine and chloroxylenol was examined. The impregnated devices produced large zones of inhibition against both organisms (mean size, 39 mm and 38 mm, respectively). In a rabbit model in which segments of silicone catheters were placed percutaneously, non-impregnated devices were twice as likely as impregnated devices to become colonised with either C. albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008).
Darouiche
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Section of Infectious Diseases, Veterans Affairs Medical Center and Center for Prostheses Infection, Baylor College of Medicine, Houston, TX 77030, USA. rdarouiche@aol.com
Mansouri
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Kojic
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D000818:Animals; D000985:Antisepsis / Q000379:methods*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D002404:Catheterization; D002710:Chlorhexidine / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D011817:Rabbits; D014992:Xylenes / Q000494:pharmacology*
D004202:Disinfectants; D014992:Xylenes; C007027:chloroxylenol; D002710:Chlorhexidine