Spectrophotometric determination of some antihistaminic drugs using 7,7,8,8-tetracyanoquinodimethane (TCNQ).
A simple and sensitive spectrophotometric method is suggested for analysis of 3 antihistaminic drugs, acrivastine (I), mequitazine (II), and dimethindene maleate (III). The method is based on reaction of the drugs with 7,7,8,8-tetracyanoquinodimethane (TCNQ) in acetonitrile to form highly stable colored products that are measured at 750, 766, and 844 nm for I and II, and 480 and 618 nm for III. Beer's law is obeyed in the ranges of 5-60 microg/mL for 1, 5-50 microg/mL for II, and 10-70 microg/mL for III. The optimum assay conditions and their applicability to the determination of the cited drugs in pharmaceutical formulations are described. The method is statistically analyzed as compared with the European Pharmacopoeia (2001) method for the analysis of dimethindene maleate and reference methods for acrivastine and mequitazine drugs revealing good accuracy and precision.
Badawey
Amr M
AM
Cairo University, Analytical Chemistry Department, Faculty of Pharmacy, Kasr El-Aini St, 11562, Cairo, Egypt.
Abbas
Samah S
SS
Loutfy
Hayam M
HM
D000097:Acetonitriles / Q000032:analysis; D002138:Calibration; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002626:Chemistry, Pharmaceutical; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000032:analysis* / Q000494:pharmacology*; D008956:Models, Chemical; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology*; D010640:Phenothiazines / Q000737:chemistry; D015203:Reproducibility of Results; D013053:Spectrophotometry / Q000379:methods*; D013816:Thermodynamics; D013997:Time Factors; D014311:Triprolidine / Q000031:analogs & derivatives / Q000737:chemistry; D014466:Ultraviolet Rays
D000097:Acetonitriles; D006634:Histamine H1 Antagonists; D009570:Nitriles; D010640:Phenothiazines; C013703:tetracyanoquinodimethane; D014311:Triprolidine; C043648:acrivastine; C006069:mequitazine; C032159:acetonitrile