Persistence of antibodies after vaccination against tick-borne encephalitis.
Active vaccination against the tick-borne encephalitis (TBE) virus has successfully been implemented in endemic countries for many years. However, little was known about persistency of antibodies after completion of the primary vaccination and/or TBE booster immunization. Five recently performed serological follow-up studies in adults have now revealed that the persistence of protective immunity following at least one booster immunization was longer than expected. Notably, studies which analyzed different age groups indicate differences between younger adults aged 18-49 years and older adults aged > or = 50 years with respect to TBE antibody persistence and the immune response following a subsequent booster dose. To summarize, the serological studies included in this analysis generally support a reconsideration of current TBE booster recommendations and a prolongation of booster intervals at least in younger adults.
Rendi-Wagner
Pamela
P
Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Austria.
Zent
Olaf
O
Jilg
Wolfgang
W
Plentz
Annelie
A
Beran
Jiri
J
Kollaritsch
Herwig
H
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D004675:Encephalitis, Tick-Borne / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007115:Immunization Schedule; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage
D000914:Antibodies, Viral; D014765:Viral Vaccines