title: The in-vitro bioactivity of mesoporous bioactive glasses.
abstract: Ordered mesoporous bioactive glasses (MBGs) with different compositions were prepared by using nonionic block copolymer surfactants as structure-directing agents through an evaporation-induced self-assembly process. Their in-vitro bioactivities were studied in detail by electron microscopy, Fourier-transform infrared spectroscopy, and inductively coupled plasma (ICP) atomic emission spectroscopy. The ICP element analysis results were further calculated in terms of the total consumption of Ca and P, Delta[Ca]/Delta[P] ratios, and ionic activity product (IP) of hydroxyapatite. Through the above analysis, it is clear that MBGs show a different structure-bioactivity correlation compared to conventional sol-gel-derived BGs. The in vitro bioactivity of MBGs is dependent on the Si/Ca ratio in the network when the other material parameters such as the mesostructure and texture properties (pore size, pore volume) are controlled. MBG 80S15C with relatively lower calcium content exhibits the best in vitro bioactivity, in contrast to conventional sol-gel-derived BGs where usually higher calcium percentage BGs (e.g. 60S35C) show better bioactivity. Calcination temperature is another important factor that influences the in vitro bioactivity. According to our results, MBGs calcined at 973K may possess the best in vitro bioactivity. The influences of the composition and calcination temperature upon bioactivity are explained in terms of the unique structures of MBGs.
authors.affiliation: Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Yan
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Huang
authors.forename: Chengzhong
authors.initials: C
authors.lastname: Yu
authors.forename: Hexiang
authors.initials: H
authors.lastname: Deng
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shizhang
authors.initials: S
authors.lastname: Qiao
authors.forename: Gaoqing
authors.initials: G
authors.lastname: Lu
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhao
mesh_terms: D018786:Bone Substitutes / Q000737:chemistry*; D002118:Calcium / Q000032:analysis; D005898:Glass / Q000737:chemistry*; D006882:Hydroxyapatites / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010758:Phosphorus / Q000032:analysis; D016062:Porosity; D012825:Silicon / Q000032:analysis; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D018786:Bone Substitutes; D006882:Hydroxyapatites; D010758:Phosphorus; D002118:Calcium; D012825:Silicon