title: [Anaphylaxis after vaccination due to hypersensitivity to gelatin].
abstract: Most allergic reactions after vaccination occur in patients sensitive to egg protein. Therefore this subject is well investigated, and the majority of common vaccines today contain only traces of egg protein. In contrast, there is little knowledge of hypersensitivities to other substances frequently contained in vaccines, e. g. antibiotics, phenol, gelatin and different preservatives. Here we report the case of a boy who had an anaphylactic reaction after being vaccinated against measles, mumps, rubella (MMR), and tick-born encephalitis (TBE) simultaneously. Different tests finally revealed a hypersensitivity to gelatin. This should be kept in mind especially during emergency care, since gelatin containing products like Haemaccel, Gelifundol or Gelofusin are widely used as colloid for resuscitation. If type 1 reactions after vaccination occur, gelatin should be taken into account as the causative agent. A medical alert card is recommended for such patients.
authors.affiliation: Kinderklinik der Johannes Gutenberg-Universität Mainz. kamin@kinder.klinik.uni-mainz.de
authors.forename: W
authors.initials: W
authors.lastname: Kamin
authors.forename: P
authors.initials: P
authors.lastname: Staubach
authors.forename: B
authors.initials: B
authors.lastname: Klär-Hlawatsch
authors.forename: F
authors.initials: F
authors.lastname: Erdnüss
authors.forename: M
authors.initials: M
authors.lastname: Knuf
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D005780:Gelatin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects*; D011239:Prednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D013806:Theophylline / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014765:Viral Vaccines / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; C464914:Encepur; D022542:Measles-Mumps-Rubella Vaccine; D014765:Viral Vaccines; D005780:Gelatin; D011239:Prednisolone; D013806:Theophylline; D011241:Prednisone