title: A study of anti-inflammatory activity of some novel alpha-amino naphthalene and beta-amino naphthalene derivatives.
abstract: In the present study, some naphthalene derivatives have been synthesized by incorporating azetidinyl and thiazolidinyl moieties at its alpha- or beta-positions such as alpha-(3-chloro-2-oxo-4-substituted)aryl-1-azetidinyl)naphthalenes 6-10, alpha-((substituted)aryl-4-oxo-1,3-thiazolidin-3-yl)naphthalenes 11-15, beta-(3-chloro-2-oxo-4-substituted aryl-1-azetidinyl)naphthalenes 21-25, and beta-(substituted aryl-4-oxo-1,3-thiazolidin-3-yl)naphthalenes 26-30. These compounds have also been screened for acute toxicity and anti-inflammatory and analgesic activities. Compounds which showed better anti-inflammatory and analgesic activities were also examined for their ulcerogenic liability and underwent a cyclooxygenase assay. Two compounds, 12 and 28, were found to exhibit potent anti-inflammatory activity as compared to the standard drugs phenylbutazone and naproxen.
authors.affiliation: Medicinal Chemistry Division, Department of Pharmacology, Lala Lajpat Rai Memorial Medical College, Meerut, India. drshalabhsharma@gmail.com
authors.forename: Shalabh
authors.initials: S
authors.lastname: Sharma
authors.forename: Tripti
authors.initials: T
authors.lastname: Singh
authors.forename: Rajan
authors.initials: R
authors.lastname: Mittal
authors.forename: K K
authors.initials: KK
authors.lastname: Saxena
authors.forename: Virendra Kishore
authors.initials: VK
authors.lastname: Srivastava
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000633:toxicity; D010147:Pain Measurement; D010437:Peptic Ulcer / Q000139:chemically induced; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009281:Naphthalenes; D011451:Prostaglandin-Endoperoxide Synthases