title: Anxiolytic-like effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
abstract: This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (Nees) Mez (Lauraceae) in animal models of open field, rota rod, elevated plus maze and hole board tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod test nor in the number of squares crossed in the open field test. However, riparin III decreased the number of grooming and rearing. In the plus maze test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the holes of the hole board test. These results show that riparin III presents anxiolytic effects in the plus maze and hole board tests which are not influenced by the locomotor activity in the open field test.
authors.affiliation: Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
authors.forename: Carla Thiciane Vasconcelos
authors.initials: CT
authors.lastname: de Melo
authors.forename: Andreisa Paiva
authors.initials: AP
authors.lastname: Monteiro
authors.forename: Caroline Porto
authors.initials: CP
authors.lastname: Leite
authors.forename: Fernando Luiz Oliveira
authors.initials: FL
authors.lastname: de Araújo
authors.forename: Vera Targino Moreira
authors.initials: VT
authors.lastname: Lima
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.forename: Marta Maria
authors.initials: MM
authors.lastname: de França Fonteles
authors.forename: Silvânia Maria Mendes
authors.initials: SM
authors.lastname: de Vasconcelos
authors.forename: Glauce Socorro
authors.initials: GS
authors.lastname: de Barros Viana
authors.forename: Francisca Cléa Florenço
authors.initials: FC
authors.lastname: de Sousa
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology; D001549:Benzamides / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D007274:Injections, Intraperitoneal; D019770:Lauraceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001549:Benzamides; C087987:riparin III; D003975:Diazepam; D014439:Tyramine