[Pro- and antioxidant processes in schizophrenics with tardive dyskinesia].
Central nervous system diseases are connected with the production of an increased amount of reactive oxygen species. Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia (TD) in schizophrenic patients in a prolonged neuroleptic treatment course.


OBJECTIVE
Evaluation of superoxide dismutase, catalase, glutathione peroxidase activity as well as lipid peroxidation by TBARS saturation in blood platelets in schizophrenic patients with or without tardive dyskinesia symptoms.


METHODS
84 paranoid schizophrenic patients took part in the study, 40 of them with TD symptoms. The groups were comparative in clinical and demographic terms. Indication of TBARS in blood platelets was performed by the Placed and coop method. GSH-Px activity was indicated by the Little and O'Brien method. CAT activity was indicated according to the Beers and coop method. CuZnSOD activity in blood platelets was indicated by the Mirsa and Fridovich method.


RESULTS
CuZnSOD activity in schizophrenic patients without TD is 820.23 and accordingly 710.75 U/g in TD symptoms patients and it is statistical essential. TBARS for patients with TD is 1.06 and accordingly without TD it is 0.92 micromol/10(9)), the difference is statistically essential. For groups with and without TD CAT activity is accordingly 19.87 and 17.93 Ub/g. For groups with and without TD GSH-Px is accordingly 32.30 and 30.48 U/g.


CONCLUSIONS
schizophrenic patients with TD symptoms have lower CuZnSOD activity and higher concentration of TBARS in platelets than patients without TD. CAT activity is higher in patients with TD symptoms. CuZnSOD activity and concentration of TBARS are in correlation with age in both studied groups.
Gałecki
Piotr
P
Klinika Psychiatrii i Zaburzeń Nerwicowych z Oddziałem Interwencji Kryzysowych UM w Lodzi.
Pietras
Tadeusz
T
Florkowki
Antoni
A
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*
D014150:Antipsychotic Agents; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase