title: Supramolecular catalysis of Strecker reaction in water under neutral conditions in the presence of beta-cyclodextrin.
abstract: An environmentally benign and highly efficient procedure for the nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction) has been developed under biomimetic conditions in water in the presence of beta-cyclodextrin to afford alpha-aminonitriles in quantitative yields. The use of cyclodextrin precludes the use of either acid or base, and the catalyst can be recycled a number of times without loss in activity.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
authors.forename: K
authors.initials: K
authors.lastname: Surendra
authors.forename: N Srilakshmi
authors.initials: NS
authors.lastname: Krishnaveni
authors.forename: A
authors.initials: A
authors.lastname: Mahesh
authors.forename: K Rama
authors.initials: KR
authors.lastname: Rao
mesh_terms: D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D009570:Nitriles; D047392:beta-Cyclodextrins; D014867:Water; C031215:betadex