title: Bone cell proliferation on carbon nanotubes.
abstract: We explored the use of carbon nanotubes (CNTs) as suitable scaffold materials for osteoblast proliferation and bone formation. With the aim of controlling cell growth, osteosarcoma ROS 17/2.8 cells were cultured on chemically modified single-walled (SW) and multiwalled (MW) CNTs. CNTs carrying neutral electric charge sustained the highest cell growth and production of plate-shaped crystals. There was a dramatic change in cell morphology in osteoblasts cultured on MWNTs, which correlated with changes in plasma membrane functions.
authors.affiliation: Department of Biochemistry, University of California, Riverside, 92521, USA. Laura.zanello@ucr.edu
authors.forename: Laura P
authors.initials: LP
authors.lastname: Zanello
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Hui
authors.initials: H
authors.lastname: Hu
authors.forename: Robert C
authors.initials: RC
authors.lastname: Haddon
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology* / Q000502:physiology; D015220:Calcium Channels / Q000378:metabolism; D002460:Cell Line; D049109:Cell Proliferation; D018118:Chloride Channels / Q000378:metabolism; D004594:Electrophysiology; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D051381:Rats
chemical_list: D015220:Calcium Channels; D018118:Chloride Channels; D037742:Nanotubes, Carbon