Synthesis of 15N-labeled phthalimide.
A new method for preparing 15N-labeled phthalimide from the reaction between phthalic anhydride and 15N-urea (99.34% 15N) in the presence of ortho-xylene is described in this work. Reaction conditions were the mole ratio of phthalic anhydride to 15N-urea (99.34% 15N) of 3-1 at 140 degrees C and under atmospheric pressure. Excessive phthalic anhydride reacted with ethanol for 90 min. The by-product of diethyl phthalate dissolving in ethanol was separated by filtration. The high yield of 96% of 15N-labeled phthalimide was obtained and the purity and abundance was 99.5% and 99.04%, respectively.
Liu
Zhanfeng
Z
College of Life Science and Technology, Beijing University of Chemical Technology, P.O. Box 75, Beijing, 100029, China.
Yuan
Qipeng
Q
D007553:Isotope Labeling / Q000379:methods; D009587:Nitrogen Isotopes / Q000737:chemistry*; D010796:Phthalic Anhydrides / Q000737:chemistry; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry*; D014508:Urea / Q000737:chemistry
D009587:Nitrogen Isotopes; D010796:Phthalic Anhydrides; D010797:Phthalimides; C037431:phthalimide; D014508:Urea; C043103:phthalic anhydride