Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia.
A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.
Linington
Roger G
RG
Department of Chemistry, University of British Columbia, Vancouver, B.C. V6T 1Z1, Canada.
Robertson
Marilyn
M
Gauthier
Annick
A
Finlay
B Brett
BB
MacMillan
John B
JB
Molinski
Tadeusz F
TF
van Soest
Rob
R
Andersen
Raymond J
RJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017691:Caribbean Region; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010944:Plants / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism
D000900:Anti-Bacterial Agents; D006017:Glycolipids; C469708:caminoside A; C508811:caminoside B; C508812:caminoside C; C508813:caminoside D