title: Effect of topical alendronate treatment on fixation of implants inserted with bone compaction.
abstract: Bone compaction has been shown to enhance the critical initial implant stability that is important for secure long-term fixation. We investigated whether topical bisphosphonate treatment improves fixation of implants inserted with bone compaction. Porous-coated titanium implants were inserted with bone compaction into the knees of eight dogs. In the right knee, topical bisphosphonate treatment was applied before bone compaction. Saline was used as a control in the left knee. The knees were observed for 4 weeks. We found an increase in total bone-to-implant contact and total bone density around the implants in the bisphosphonate-treated group. These were results of increased nonvital bone-to-implant contact and increased nonvital periimplant bone density. No change in biomechanical fixation was found. Studies with a longer followup are needed to investigate whether the preservative effect of alendronate on nonvital bone might enhance implant fixation by osteoconduction.
authors.affiliation: Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark. tvj@studmed.au.dk
authors.forename: Thomas
authors.initials: T
authors.lastname: Jakobsen
authors.forename: Søren
authors.initials: S
authors.lastname: Kold
authors.forename: Joan E
authors.initials: JE
authors.lastname: Bechtold
authors.forename: Brian
authors.initials: B
authors.lastname: Elmengaard
authors.forename: Kjeld
authors.initials: K
authors.lastname: Søballe
mesh_terms: D000287:Administration, Topical; D019386:Alendronate / Q000627:therapeutic use*; D000818:Animals; D019643:Arthroplasty, Replacement / Q000379:methods*; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004285:Dogs; D019544:Equipment Failure Analysis; D005260:Female; D005269:Femur / Q000601:surgery*; D033081:Shear Strength; D016474:Weight-Bearing
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate