Stereoselective synthesis of axially chiral N-C bonds in N-aryl indoles.
[reaction: see text] N-Aryl indoles with axially chiral N-C bonds were synthesized by stereoselective nucleophilic aromatic substitution reactions of planar chiral arene chromium complexes. Stereoselective chromium tricarbonyl migration was achieved in the sterically hindered N-aryl indole chromium complex by refluxing in toluene.
Kamikawa
Ken
K
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan. kamikawa@c.s.osakafu-u.ac.jp
Kinoshita
Shunsuke
S
Matsuzaka
Hiroyuki
H
Uemura
Motokazu
M