Anchored cAMP signaling: onward and upward - a short history of compartmentalized cAMP signal transduction.
Intracellular signal transduction pathways require a high degree of spatial and temporal resolution in order to deliver the appropriate outputs. Specific signaling mediated by the ubiquitous second messenger cAMP and its effector, the cAMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A-kinase anchoring proteins (AKAPs). This review discusses the history and future of anchored cAMP signaling pathways.
Smith
F Donelson
FD
Howard Hughes Medical Institute and Vollum Institute, Oregon Health and Sciences University, MRB 322, L474, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. smithdon@ohsu.edu
Scott
John D
JD
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002451:Cell Compartmentation; D000242:Cyclic AMP / Q000266:history* / Q000378:metabolism*; D049673:History, 20th Century; D049674:History, 21st Century; D008954:Models, Biological; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D000242:Cyclic AMP