title: Rhodium-catalyzed asymmetric synthesis of indanones: development of a new "axially chiral" bisphosphine ligand.
abstract: A rhodium-catalyzed asymmetric isomerization of racemic alpha-arylpropargyl alcohols to beta-chiral indanones has been developed. High enantioselectivity has been realized by the use of a newly developed axially chiral bisphosphine ligand. This ligand is unique in the sense that its axial chirality is fixed to a single configuration upon complexation to a transition metal due to other chiral axes existing within the same molecule.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Shintani
authors.forename: Keiji
authors.initials: K
authors.lastname: Yashio
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nakamura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okamoto
authors.forename: Toyoshi
authors.initials: T
authors.lastname: Shimada
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi