[Study on appraisement and determination GHB levels in hair].
OBJECTIVE
The possibility for the identification of GHB administration through hair analysis was investigated to provide method and information for toxicology examination of GHB. METHODS A GC/MS assay for GHB in hair was developed. Endogenous levels of GHB in hair, time course of GHB in hair, relationship between GHB levels in hair and hair color or administration dose were also established by guinea pig model.


RESULTS
Endogenous levels of GHB in guinea pig black hair and human black hair were (3.01 +/- 1.41) ng/mg (n=28) and (1.02 +/- 0.27) ng/mg (n=20), respectively. GHB levels in black hair were increased by GHB administration and related with drug dosage, and also much higher than in brown and white hair.


CONCLUSIONS
Analysis of GHB in hair is suitable for investigation of GHB abuse in forensic toxicology and GHB level in segmental analysis compared with endogenous level of GHB may provide useful information about GHB administration.
Shen
Min
M
Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China.
Liu
Xiao-qian
XQ
Liu
Wei
W
Xiang
Ping
P
Shen
Baohua
B
D000818:Animals; D004305:Dose-Response Relationship, Drug; D053593:Forensic Toxicology / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006168:Guinea Pigs; D006197:Hair / Q000737:chemistry*; D006200:Hair Color; D006801:Humans; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D008297:Male; D015813:Substance Abuse Detection / Q000379:methods*; D013997:Time Factors
D006885:Hydroxybutyrates; C111420:4-hydroxybutyric acid