Sex differences in early mortality of patients undergoing primary stenting for acute myocardial infarction.
BACKGROUND
Limited information exists regarding the impact of gender on in-hospital outcome after primary stenting for acute myocardial infarction (AMI).


RESULTS
A total of 2,981 patients (790 women and 2,191 men) participated in the study who were admitted within 24 h after symptom onset and underwent emergency primary stenting for AMI. Compared with men, women were significantly older; had higher incidences of hypertension, diabetes mellitus, hyperlipidemia, Killip class > or =2, and cardiogenic shock; had a higher blood glucose level and a lower serum creatinine level on admission. Other baseline characteristics, including the incidences of ST-segment elevation AMI, anterior infarction, 3-vessel disease, initial or final Thrombolysis in Myocardial Infarction (TIMI) flow grade did not significantly differ between the sexes. The in-hospital mortality rate was significantly higher in women than in men (9.4% vs 5.2%, p<0.001). On multivariate analysis, age, Killip class, blood glucose level, serum creatinine level, and final TIMI grade were independent predictors of in-hospital death, but female gender was not (odds ratio 1.01, p=0.69).


CONCLUSIONS
Our findings suggest that in patients undergoing primary stenting for AMI, women have higher in-hospital mortality than men, but female gender itself is not independently associated with increased in-hospital mortality after adjustment for baseline differences.
Kosuge
Masami
M
Division of Cardiology, Yokohama City University Medical Center, Japan.
Kimura
Kazuo
K
Kojima
Sunao
S
Sakamoto
Tomohiro
T
Ishihara
Masaharu
M
Asada
Yujiro
Y
Tei
Chuwa
C
Miyazaki
Shunichi
S
Sonoda
Masahiro
M
Tsuchihashi
Kazufumi
K
Yamagishi
Masakazu
M
Ikeda
Yoshihiko
Y
Shirai
Mutsunori
M
Hiraoka
Hisatoyo
H
Inoue
Takeshi
T
Saito
Fumio
F
Ogawa
Hisao
H
D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000401:mortality* / Q000601:surgery*; D012189:Retrospective Studies; D012727:Sex Characteristics; D015607:Stents; D016896:Treatment Outcome