Notch is constitutively active in Theileria-transformed B cells and can be further stimulated by the filarial nematode-secreted product, ES-62.
Theileria parva-infected B cells express Jagged-1 and activate Notch signalling in a parasite-dependent manner. ES-62, a filarial nematode-secreted phosphorylcholine-containing glycoprotein, is able to further stimulate Notch-mediated signalling in parasitized cells. Notch is also activated to a similar extent by addition of exogenous IL-10, and this occurs prior to any increase in proliferation in T. parva-infected B cells.
Chaussepied
M
M
Michie
A M
AM
Moreau
M-F
MF
Harnett
M M
MM
Harnett
W
W
Langsley
G
G
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism* / Q000469:parasitology; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002417:Cattle; D002460:Cell Line; D006023:Glycoproteins / Q000494:pharmacology; D015801:Helminth Proteins / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D016753:Interleukin-10 / Q000494:pharmacology; D008565:Membrane Proteins / Q000378:metabolism; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D000072099:Serrate-Jagged Proteins; D016797:Theileria parva; D013801:Theileriasis / Q000378:metabolism*; D014170:Transformation, Genetic
D002135:Calcium-Binding Proteins; C435884:ES-62 protein, Acanthocheilonema viteae; D006023:Glycoproteins; D015801:Helminth Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; D000072099:Serrate-Jagged Proteins; D016753:Interleukin-10