title: Prognostic factors for first recurrence in patients with retroperitoneal sarcoma.
abstract: BACKGROUND
  Retroperitoneal sarcomas are characterized by a high local recurrence rate despite optimal surgical treatment. The definition of prognostic factors for recurrence could help offer high-risk patients a closer follow-up and a multidisciplinary therapeutic approach.
  
  
  METHODS
  A cohort of 40 patients treated for a primary retroperitoneal sarcoma was retrospectively analyzed. Median follow-up was 24 months. Patient (sex and age), tumor (maximal size, histologic type, tumor localization, and histologic grade), and treatment (complete vs. incomplete surgery) characteristics were included in univariate and multivariate prognostic factor analyses.
  
  
  RESULTS
  After a median follow-up of 24 months (range 3-121), the overall recurrence rate was 65%. Median time between initial surgery and recurrence was 15 months (range 11.5-29.5). In univariate analysis, surgical positive margins (P = 0.011), bilateral tumors (P = 0.0034), nonliposarcoma histologic subtypes (P = 0.043), and a high histologic grade (P = 0.0072) were associated with an increased recurrence rate. All these factors except the histologic subtypes retained an independent prognostic value in the multivariate analysis. Death was strongly related to recurrence (P = 0.0033).
  
  
  CONCLUSIONS
  The optimal treatment of patients with primary retroperitoneal sarcoma should be based on radical surgery, with en bloc organ resection if necessary, to minimize the risk of positive margins. In high-risk patients, close follow-up is mandatory to offer optimal subsequent surgical procedures. The impact of a multidisciplinary therapeutic approach remains to be proved.
authors.affiliation: Department of Urology, Centre Hospitalier Universitaire, Nîmes, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Avancès
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mottet
authors.forename: Aba
authors.initials: A
authors.lastname: Mahatmat
authors.forename: Eliette
authors.initials: E
authors.lastname: Chapuis
authors.forename: Isabelle
authors.initials: I
authors.lastname: Serre
authors.forename: Stéphane
authors.initials: S
authors.lastname: Culine
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000453:epidemiology*; D012509:Sarcoma / Q000453:epidemiology*