title: [Psychophysiological analysis of bipolar disorder treatment with functional magnetic resonance imaging (fMRI), spectroscopic (1H-MRS) and volumetric MRI assessment of CNS: report of three cases].
abstract: BACKGROUND
  Neuroimaging studies, including MRI, have identified various abnormalities in patients with bipolar disorders. However those findings have been inconsistent with regard to different MRI techniques, clinical and neurocognitive assessments as well as treatment results. So far the functional magnetic resonance imaging (fMRI) studies haven't been performed in psychiatric patients in Poland.
  
  
  OBJECTIVE
  The aim of the present study was to use fMRI, as well as two other MRI techniques to examine their relationships with clinical and neurocognitive assessments and the effectiveness of psychiatric treatment of bipolar disorders.
  
  
  METHODS
  In this preliminary report, three bipolar patients were tested and compared with one healthy subject by means of three MRI techniques: fMRI, prefrontal spectroscopy (1H-MRS) and volumetric MRI of hippocampus regions. Clinical (MADRS) and neurocognitive (Stroop-like) assessments were performed.
  
  
  RESULTS
  Clinical, cognitive and MRI findings (fMRI, 1H-MRS, vMRI) were highly or moderately correlated.
  
  
  CONCLUSIONS
  MRI techniques may effectively support both clinical and neurocognitive assessments of the ongoing treatment in bipolar patients.
authors.affiliation: Pracownia Zaburzeń Afektywnych AM w Warszawie.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Loza
authors.forename: Leszek
authors.initials: L
authors.lastname: Królicki
authors.forename: Klaudiusz
authors.initials: K
authors.lastname: Papierski
authors.forename: Iwona
authors.initials: I
authors.lastname: Mazurek
authors.forename: Anna
authors.initials: A
authors.lastname: Mosiołek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kokoszka
authors.forename: Renata
authors.initials: R
authors.lastname: Andrysiak
mesh_terms: D001714:Bipolar Disorder / Q000503:physiopathology* / Q000628:therapy*; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D016896:Treatment Outcome