Enantioselective intramolecular hydroamination catalyzed by lanthanide ate complexes coordinated by N-substituted (R)-1,1'-binaphthyl-2,2'-diamido ligands.
Ytterbium and lutetium ionic complexes derived from enantiopure substituted (R)-binaphthylamine ligands, of the general formula [Li(THF)n][Ln[(R)-C20H12(NR)2]2], have been investigated for the hydroamination/cyclization of several aminopentenes and an aminohexene. Complexes with isopropyl or cyclohexyl substituents on nitrogen atoms were found to be efficient catalysts under mild conditions for the formation of N-containing heterocycles with enantiomeric excesses up to 78%.
Riegert
David
D
Laboratoire de Catalyse Moléculaire, ICMMO, UMR CNRS 8182, Université Paris-sud, 91405 Orsay, France.
Collin
Jacqueline
J
Meddour
Abdelkrim
A
Schulz
Emmanuelle
E
Trifonov
Alexander
A