Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide).
The in vitro antimalarial activity of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide) and their derivatives, against the Plasmodium falciparum FCR-3 strain (ATCC 30932, chloroquine-sensitive) was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 3.5microM to 10nM. The chain length of the N1-alkyl moiety was found to be very beneficial in terms of antimalarial activity, and in this series of compounds, the most appropriate N1-alkyl chain length was found to be eight.
Fujimoto
Kanji
K
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
Morisaki
Daiki
D
Yoshida
Munehiro
M
Namba
Tetsuto
T
Hye-Sook
Kim
K
Wataya
Yusuke
Y
Kourai
Hiroki
H
Kakuta
Hiroki
H
Sasaki
Kenji
K
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D051379:Mice; D010963:Plasmodium falciparum / Q000187:drug effects; D011726:Pyridinium Compounds / Q000737:chemistry / Q000494:pharmacology*
D000962:Antimalarials; D011726:Pyridinium Compounds