Kikuchi disease in Asian children.
OBJECTIVE
Kikuchi disease is a benign, self-limiting condition of unknown aetiology, often manifesting as cervical lymphadenopathy and fever. The disease usually manifests itself in adulthood and paediatric reports are uncommon. The aims of this study are to report the features of Kikuchi disease in the local paediatric population, and to raise the awareness of this entity among clinicians involved in treating these children.


METHODS
This is a retrospective series of nine paediatric cases of Kikuchi disease treated in KK Women's and Children's Hospital, Singapore. The clinical presentation, subsequent clinical course and laboratory findings of these patients were reviewed.


RESULTS
The patients ranged in age from 7 to 16 years, and included six males and three females. All nine patients presented with fever and cervical lymphadenopathy. Hepatosplenomegaly was present in one child. The erythrocyte sedimentation rate was raised to variable extents, but there was no other significant haematological, serological or microbiological abnormality. In all cases the diagnosis was made on the basis of histological findings.


CONCLUSIONS
Kikuchi disease in the paediatric population is not as uncommon as previously thought, and should be considered in the differential diagnosis of any child with fever of unknown origin or cervical lymphadenopathy. Early recognition will minimize unnecessary investigations and prolonged empirical treatments.
Chen
Ching K
CK
Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore.
Low
Yee
Y
Akhilesh
Meenakshi
M
Jacobsen
Anette S
AS
D000293:Adolescent; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis / Q000209:etiology; D020042:Histiocytic Necrotizing Lymphadenitis / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008499:Medical Records; D009333:Neck; D012846:Singapore