Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan (5-HTP) in mice.
We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. It was reported that administration of 5-HTP elicits hypophagia in rodents and humans. In the present study, we examined involvement of leptin in 5-HTP-elicited decreases in the milk intake of fasted mice. Serum leptin levels increased with increases in milk intake in mice, while 5-HTP strongly decreased milk intake in fasted mice compared to that in the control group. Serum leptin levels in fasted mice treated with 5-HTP were similar to those control mice after milk intake. As leptin is a powerful anorectic signal, 5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.
Yamada
Jun
J
Department of Pharmacology, Kobe Pharmaceutical University, Japan. j-yamada@kobepharma-u.ac.jp
Sugimoto
Yumi
Y
Ujikawa
Masanori
M
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D004435:Eating / Q000187:drug effects*; D020738:Leptin / Q000502:physiology*; D008297:Male; D051379:Mice; D008892:Milk
D020738:Leptin; D006916:5-Hydroxytryptophan