Finding the molecular basis of complex genetic variation in humans and mice.
I survey the state of the art in complex trait analysis, including the use of new experimental and computational technologies and resources becoming available, and the challenges facing us. I also discuss how the prospects of rodent model systems compare with association mapping in humans.
Mott
Richard
R
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. richard.mott@well.ox.ac.uk
D000818:Animals; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D023281:Genomics; D006801:Humans; D051379:Mice; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable