[The effect of ethanol on sexual function of males and its mechanism].
Though an adequate volume of ethanol relieves nervousness and enhances sexual desire,long term and excessive intake of ethanol can induce sexual dysfunction. The reasons that ethanol results in sexual dysfunction are as follows: ethanol inhibits the hypothalamo-pituitary-testes axis and decreases serum testosterone level. The decline of smooth muscle, choline acetyltransferase and nitric oxide synthase in the penis may be responsible for it.
Gan
Xiu-Guo
XG
Department of Urology, the First Affiliated Hospital of Haerbin Medical University, Haerbin, Heilongriang 150001, China. ganxiuguo@yahoo.com.cn
An
Rui-Hua
RH
Zhong
De-Bin
DB
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010413:Penis / Q000166:cytology* / Q000378:metabolism*; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D000431:Ethanol; D013739:Testosterone; D019001:Nitric Oxide Synthase; D000110:Acetylcholinesterase