title: Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice.
abstract: CHS 828, a cyanoguanidine with potent experimental antitumoural activity, inhibits activation of nuclear factor-kappaB. In the present study, marked antitumoural activity of peroral CHS 828 was shown against three different human neuroendocrine tumours, midgut carcinoid (GOT1), pancreatic carcinoid (BON), and medullary thyroid carcinoma (GOT2), transplanted in nude mice. Our results indicate that CHS 828 can be a candidate drug for treatment of neuroendocrine tumours.
authors.affiliation: The Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg, Sweden. viktor.johanson@medfak.gu.se
authors.forename: Viktor
authors.initials: V
authors.lastname: Johanson
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Arvidsson
authors.forename: Lars
authors.initials: L
authors.lastname: Kölby
authors.forename: Peter
authors.initials: P
authors.lastname: Bernhardt
authors.forename: Christina
authors.initials: C
authors.lastname: Swärd
authors.forename: Ola
authors.initials: O
authors.lastname: Nilsson
authors.forename: Håkan
authors.initials: H
authors.lastname: Ahlman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003486:Cyanides / Q000627:therapeutic use*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D018358:Neuroendocrine Tumors / Q000188:drug therapy*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D003486:Cyanides; D006146:Guanidines; C401312:N-(6-chlorophenoxyhexyl)-N''-cyano-N''-4-pyridylguanidine