Development of the Pictet-Spengler reaction catalyzed by AuCl3/AgOTf.
Mild and efficient AuCl3/AgOTf-catalyzed Pictet-Spengler reactions were developed to afford in good yields a variety of tetrahydroisoquinoline and tetrahydro-beta-carboline ring systems, which constitute important motifs in biologically active natural and synthetic organic compounds.
Youn
So Won
SW
Department of Chemistry, Pukyong National University, Busan 608-737, Korea. sowony@pknu.ac.kr
D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D017612:Gold Compounds / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
D002243:Carbolines; D017612:Gold Compounds; D008698:Mesylates; D044005:Tetrahydroisoquinolines; C038016:gold chloride; C009804:tryptoline; C012077:trifluoromethanesulfonic acid