title: Stereoselective synthesis of bicyclic lactones by annelation with functionalized orthoesters.
abstract: An efficient two-step annelation of functionalized orthoesters with trimethylsilyloxyfuran derivatives, which delivers suitably decorated bicyclo[3.n.0]lactones in high overall yields and with complete diastereocontrol of up to three contiguous stereocenters, is reported.
authors.affiliation: Université Catholique de Louvain, Département de Chimie, 1 Place Louis Pasteur, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: Nuno
authors.initials: N
authors.lastname: Maulide
authors.forename: István E
authors.initials: IE
authors.lastname: Markó
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters; D005663:Furans / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D001643:Bridged Bicyclo Compounds; D004952:Esters; D005663:Furans; D007783:Lactones; D014297:Trimethylsilyl Compounds