title: [Study on determination and distribution of GHB in biological fluids and tissues of acute poisoned rats].
abstract: OBJECTIVE
  e To investigate the distribution of GHB in biological fluids and tissues and provide methodand information for detcetion of GHB in Biological Fluids and Tissues METHOD The concentrations of GHB in Biological Fluids and Tissues were analyzed by gas chromatography-mass spectrometry; Two groups of rats were fed with 1000 mg/kg of GHB and were killed at 1 hour and 3 hours post dose, respectively. RESULTS GHB concentrations of the administrated groups distributed in a degressive order of urine, stomach, blood, intestine, kidney, lung, spleen, heart, liver and brain.
  
  
  CONCLUSIONS
  Urine was the best specimen for the determination of GHB concentrations in biological fluids and tissues.
authors.affiliation: Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Shen
authors.forename: Xiao-qian
authors.initials: XQ
authors.lastname: Liu
authors.forename: Bao-hua
authors.initials: BH
authors.lastname: Shen
authors.forename: Ping
authors.initials: P
authors.lastname: Xiang
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D005753:Gastric Mucosa / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000097:blood / Q000378:metabolism* / Q000506:poisoning*; D007668:Kidney / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015813:Substance Abuse Detection / Q000379:methods*; D014018:Tissue Distribution
chemical_list: D006885:Hydroxybutyrates; C111420:4-hydroxybutyric acid