Expression of serine protease matriptase in renal cell carcinoma: correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters.
Serine protease matriptase (matriptase) cleaves and activates proteins implicated in the progression of cancer and represents a potential therapeutic target. Immunohistochemical analysis of matriptase was performed in tissue microarrays of 168 renal cell carcinomas (RCCs). All subtypes of RCC showed significant immunohistochemical expression of matriptase. In contrast, no expression occurred in areas of RCC with sarcomatous differentiation (SRCC) and in normal collecting tubules. The matriptase scores were significantly higher in papillary RCC (341+/-28) and clear cell RCC with granular cell differentiation (GRCC; 324+/-27) than in other histologic subtypes of RCC. In GRCC, matriptase scores were correlated with TNM staging and nuclear grading. Matriptase was overexpressed in all subtypes of RCC, and matriptase scores could distinguish between conventional clear cell RCC, GRCC, and SRCC.
Jin
Jong-Shiaw
JS
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Gong Road, Taipei, Taiwan, R.O.C.
Chen
Ann
A
Hsieh
Dar-Shih
DS
Yao
Chen-Wen
CW
Cheng
Ming-Fang
MF
Lin
Yeh-Feng
YF
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D002454:Cell Differentiation; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D012697:Serine Endopeptidases / Q000032:analysis* / Q000502:physiology
D014408:Biomarkers, Tumor; D012697:Serine Endopeptidases; C485595:matriptase