Arylanthranilodinitriles: a new biaryl class of antileishmanial agents.
A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20microg/mL concentrations, respectively.
Singh
Fateh V
FV
Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Vatsyayan
Rit
R
Roy
Uma
U
Goel
Atul
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D007893:Leishmania donovani / Q000187:drug effects*; D051379:Mice
D000981:Antiprotozoal Agents