title: Electrophysiological subtypes and prognosis of childhood Guillain-Barré syndrome in Japan.
abstract: Guillain-Barré syndrome (GBS) is classified into acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), but little is known about the incidence of the subtypes and the prognosis of childhood GBS. To elucidate the features and long-term prognosis, clinical and electrophysiological data for 31 Japanese GBS children were reviewed. By electrodiagnostic criteria, children were classified as having AIDP (35%) or AMAN (48%), or were unclassified (16%). The AMAN children invariably had normal sensory nerve potentials. Between the two groups, age, sex, and clinical disability did not differ significantly, but the AIDP children more frequently had cranial and sensory nerve involvement, and the AMAN children more frequently had preceding gastroenteritis. By 6 months after onset, all the AIDP and 80% of the AMAN children had regained the ability to walk; by 2 years, all but one of the AMAN children could walk. In Japanese childhood GBS, the proportion of AIDP and AMAN appears to be similar. Recovery is generally favorable in both subtypes, but some of the AMAN children experienced delayed recovery.
authors.affiliation: Department of Pediatrics, Chiba University School of Medicine, Chiba, Japan.
authors.forename: Kasumi
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
authors.forename: Sonoko
authors.initials: S
authors.lastname: Misawa
authors.forename: Katsunori
authors.initials: K
authors.lastname: Fujii
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
authors.forename: Takamichi
authors.initials: T
authors.lastname: Hattori
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kohno
mesh_terms: D000200:Action Potentials; D000208:Acute Disease; D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D001369:Axons / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D016537:Gangliosidosis, GM1 / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G