title: [Verrucous carcinoma versus papillary squamous cell carcinoma of the larynx 9 cases report].
abstract: OBJECTIVE
  To investigate the clinical, pathological character and differential diagnosis between verrucous carcinoma (VC) and papillary squamous cell carcinoma (PSCC) of the larynx.
  
  
  METHODS
  Four cases of VC and five cases of PSCC of larynx in our hospital between 1991 approximately 2003 were studied retrospectively, the clinical and pathology character of VC and PSCC were observed.
  
  
  RESULTS
  Highly differentiated squamous cell and epithelial pearls or keratinized matter can be seen in the four cases of VC. Invasion of the basement membrane is often nonetheless, moderate to serve inflammatory reaction usually exist in the stroma adjacent to the advancing margin, no cervical lymph node metastases, no local recurrence and the prognosis is excellent. Exophytic malignant proliferation of the squamous cell with fibrovascular core can be seen in all the cases of PSCC, cell pathology is similar to the conventional SCC but no cervical metastases were observed and the prognosis is better than the conventional SCC.
  
  
  CONCLUSIONS
  The external appearance of VC and PSCC is similar, but there are discrepancy in the cellular differentiation and the atypia of the tumor cells, stroma inflammatory reaction, recurrence, regional metastases, treatment, prognosis. Accurate differential diagnosis requires close cooperation between the laryngologist and the histopathologist.
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital of Jinan University, Guangzhou, China.
authors.forename: Jiqun
authors.initials: J
authors.lastname: Wang
authors.forename: Long
authors.initials: L
authors.lastname: He
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Shan
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology*; D018289:Carcinoma, Verrucous / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis