Study on drug release behaviour of CDHA/chitosan nanocomposites--effect of CDHA nanoparticles.
To explore the effect of nanofiller-polymer interaction on the drug release behaviour from a monolithic membrane prepared by Ca-deficient hydroxyapatite (CDHA)/chitosan nanocomposite, release kinetics was investigated in terms of different synthetic processes, i.e. in situ and ex situ routes, and various amounts of CDHA. It was found that a higher value of diffusion exponent (n) was obtained for the membranes in situ synthesized compared with those ex situ prepared. In addition, the n value of the membranes in situ synthesized increased with increasing CDHA amount, which remained in the range below 10wt.%. However, as CDHA content exceeded 30%, the n value remained constant. It indicates that the drug diffusion mechanism is altered by the CDHA-chitosan interaction which is strongly influenced by both the synthesis process and the concentration of the CDHA nanofiller in the membrane. On the other hand, a lower permeability (P) value of the membranes was observed for those prepared via the in situ process. Furthermore, P value decreased and increased with increasing CDHA amount in the range below and above 10wt.%, respectively. It demonstrates that CDHA nanofillers act either diffusion barrier or diffusion enhancer for the CDHA/chitosan membranes, which is determined by the concentration of CDHA nanofiller and the synthesis route of nanocomposite.
Liu
Tse-Ying
TY
Department of Materials Science and Engineering, National Chiao Tung University, 1001 Ta-hsueh Rd., Hsinchu, Taiwan, ROC.
Chen
San-Yuan
SY
Li
Jo-Hao
JH
Liu
Dean-Mo
DM
D001672:Biocompatible Materials; D048271:Chitosan / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004058:Diffusion; D004337:Drug Carriers; D017886:Durapatite / Q000737:chemistry*; D066298:In Vitro Techniques; D007700:Kinetics; D008567:Membranes, Artificial; D008954:Models, Biological; D053758:Nanoparticles / Q000648:ultrastructure; D010539:Permeability; D012995:Solubility; D013818:Thermogravimetry; D014805:Vitamin B 12 / Q000378:metabolism
D001672:Biocompatible Materials; D004337:Drug Carriers; D008567:Membranes, Artificial; D048271:Chitosan; D017886:Durapatite; D014805:Vitamin B 12