title: Effect of a casein/calcium phosphate-containing tooth cream and fluoride on enamel erosion in vitro.
abstract: The aim of this study was to determine whether a tooth cream containing casein/calcium phosphate (CasCP) protects enamel against erosion. Sixty bovine enamel specimens were prepared for profilometry and distributed into five groups. Specimens were rinsed with artificial saliva interrupted by 1% citric acid (pH 2.3) for 30 s 6 times daily for 14 days. Group 1 (n=12) was not treated (control); in group 2 (n=12) CasCP was applied for 120 s twice daily; in group 3 (n=12) 250 ppm fluoride as NaF was applied for 120 s twice daily; in group 4 (n=12) CasCP was applied for 120 s, then 250 ppm fluoride for 120 s twice daily, and in group 5 (n=12) amine fluoride (AmF) gel (12,500 ppm fluoride) was applied for 120 s twice daily. Differences between groups with respect to erosive enamel loss (profilometrically determined depth after 7 and 14 days) were tested by the Mann-Whitney test (alpha=0.05). After 7/14 days' erosive cycling, specimens treated with AmF gel showed significantly less enamel loss (18.5/35.5 microm; medians) than those treated with CasCP (25.5/46.9 microm), 250 ppm fluoride (25.0/ 40.9 microm), CasCP and 250 ppm fluoride (23.9/47.4 microm) or with no treatment (26.3/49.8 microm). It is concluded that highly fluoridated acidic AmF gel can protect enamel against erosion while CasCP, 250 ppm fluoride or a combination of CasCP and 250 ppm fluoride provide little protection.
authors.affiliation: Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Göttingen, Göttingen, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Lennon
authors.forename: M
authors.initials: M
authors.lastname: Pfeffer
authors.forename: W
authors.initials: W
authors.lastname: Buchalla
authors.forename: K
authors.initials: K
authors.lastname: Becker
authors.forename: S
authors.initials: S
authors.lastname: Lennon
authors.forename: T
authors.initials: T
authors.lastname: Attin
mesh_terms: D000588:Amines / Q000008:administration & dosage; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage; D002130:Calcium Phosphates / Q000008:administration & dosage*; D002364:Caseins / Q000008:administration & dosage*; D002417:Cattle; D003743:Dental Enamel / Q000187:drug effects; D003747:Dental Enamel Solubility / Q000187:drug effects; D003802:Dentifrices / Q000008:administration & dosage* / Q000737:chemistry; D003959:Diamines; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005459:Fluorides / Q000008:administration & dosage; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D012969:Sodium Fluoride / Q000008:administration & dosage; D018709:Statistics, Nonparametric; D014002:Tin Fluorides / Q000008:administration & dosage; D014077:Tooth Erosion / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000588:Amines; D002130:Calcium Phosphates; D002364:Caseins; D003802:Dentifrices; D003959:Diamines; D004338:Drug Combinations; D005460:Fluorides, Topical; D014002:Tin Fluorides; C075174:amine fluoride gel; C495399:Olaflur; D012969:Sodium Fluoride; C020243:calcium phosphate; D001205:Ascorbic Acid; D005459:Fluorides