title: Astrocytoma with pilomyxoid features presenting in an adult.
abstract: Pilomyxoid histology is presently considered to occur in pediatric brain tumors. We report an astrocytoma with pilomyxoid features presenting in an adult and discuss its relationship to both the established childhood pilomyxoid astrocytoma (PMA) and recently reported tanycytoma. A 28-year-old man with medically intractable seizures presented for surgical evaluation. MRI revealed a discrete lesion in the right amygdala/uncus region. The patient elected for craniotomy with stereotactic temporal lobe resection and excision of the lesion. Postoperatively, the patient has done well. At 30-month follow up, he is seizure free and without evidence of tumor recurrence. We report an astrocytoma with pilomyxoid features presenting in an adult, illustrating that while this histological pattern is most commonly seen in children, it may also affect older individuals. Recognition of this enigmatic pattern in adult gliomas expands the currently accepted epidemiology for this lesion.
authors.affiliation: Department of Neurological Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA. rjk2103@columbia.edu
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Komotar
authors.forename: J
authors.initials: J
authors.lastname: Mocco
authors.forename: Brad E
authors.initials: BE
authors.lastname: Zacharia
authors.forename: David A
authors.initials: DA
authors.lastname: Wilson
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Kim
authors.forename: Peter D
authors.initials: PD
authors.lastname: Canoll
authors.forename: Robert R
authors.initials: RR
authors.lastname: Goodman
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male