title: A long-distance relationship between RNAi and Polycomb.
abstract: RNA interference (RNAi) pathways can result in sequence-specific transcriptional gene silencing on the level of chromatin. In this issue of Cell, Grimaud et al. (2006) reveal that the RNAi machinery is required for long-distance physical interactions between chromosomes mediated by the Polycomb repressive complex. These results suggest that the RNAi machinery may regulate higher-order nuclear organization.
authors.affiliation: Department of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
authors.forename: Elissa P
authors.initials: EP
authors.lastname: Lei
authors.forename: Victor G
authors.initials: VG
authors.lastname: Corces
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D020868:Gene Silencing; D008957:Models, Genetic; D063150:Polycomb Repressive Complex 1; D034622:RNA Interference; D015398:Signal Transduction / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; C066770:Pc protein, Drosophila; D063150:Polycomb Repressive Complex 1