Therapies for HIV with RNAi.
RNA interference (RNAi) is a process in which double-stranded RNA triggers the silencing of gene expression in a sequence-specific manner. In mammalian cells, approximately 21-nucleotide small interfering RNA duplexes guide cognate mRNA degradation in a sequence-specific manner by RNA-induced silencing complex. RNAi was successfully applied to inhibit different stages of HIV-1 replication. Recent viral and host cell targets for RNAi that have been used to inhibit HIV-1 are described. The problem with the delivery of RNA duplexes to the target cells and the strategies used by HIV-1 to escape inhibition by RNAi are also discussed.
Nekhai
Sergei
S
Howard University, Center for Sickle Cell Disease, 2121 Georgia Ave NW, Washington, DC 20059, USA. snekhai@howard.edu
Jerebtsova
Marina
M
D000818:Animals; D005814:Genes, Viral / Q000235:genetics; D015658:HIV Infections / Q000378:metabolism / Q000628:therapy* / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D006801:Humans; D034622:RNA Interference / Q000502:physiology; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D013379:Substrate Specificity
D034741:RNA, Small Interfering