[Stem cell perspectives in myocardial infarctions].
Myocardial infarction is the leading cause of congestive heart failure and death in industrializated countries. The cellular cardiomyoplasty has emerged as an alternative treatment in the regeneration of infarted myocardial tissue. In animals' models, different cellular lines such as cardiomyocites, skeletal myoblasts, embryonic stem cells and adult mesenchymal stem cells have been used, resulting in an improvement in ventricular function and decrease in amount of infarcted tissue. The first three cells lines have disvantages as they are allogenics and are difficult to obtain. The adult mesenchymal stem cells are autologous and can be obtained throught the aspiration of bone marrow or from peripherical circulation, after stimulating with cytokines (G-CSF). The implantation in humans with recent and old myocardial infarction have shown improvements similar to those shown in animal models. These findings encourage the continued investigation in the mechanism of cellular differentiation and implantation methods in infarcted myocardial tissue.
Aceves
José Luis
JL
División de Cirugía Cardiaca y Cardiología, Hematología, Ecocardiografía y Medicina Nuclear del CMN 20 de Noviembre ISSSTE, México, DF. aceves996@hotmail.com
Archundia
Abel
A
Díaz
Guillermo
G
Páez
Araceli
A
Masso
Felipe
F
Alvarado
Martha
M
López
Manuel
M
Aceves
Rocío
R
Ixcamparij
Carlos
C
Puente
Adriana
A
Vilchis
Rafael
R
Montaño
Luis Felipe
LF
D000818:Animals; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006133:Growth Substances / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000473:pathology / Q000601:surgery*; D032383:Myocytes, Cardiac / Q000166:cytology; D013234:Stem Cells / Q000145:classification; D014182:Transplantation, Autologous
D006133:Growth Substances; D016179:Granulocyte Colony-Stimulating Factor