Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica".
[structure: see text] Two structurally novel cyclopenta[a]indene glycosides, cyanosporasides A and B (1 and 2) have been isolated from the culture broth of a new species of the obligate marine actinomycete genus Salinispora. The structures and absolute stereochemistries of these compounds were determined by spectral and chemical methods. The cyanosporasides possess a new 3-keto-pyranohexose sugar as well as a cyano- and chloro-substituted cyclopenta[a]indene ring system. The cyanosporasides are proposed to be cyclization products of an enediyne precursor.
Oh
Dong-Chan
DC
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093, USA.
Williams
Philip G
PG
Kauffman
Christopher A
CA
Jensen
Paul R
PR
Fenical
William
W
D039903:Actinobacteria / Q000737:chemistry*; D003500:Cyclization; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D007192:Indenes / Q000737:chemistry* / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure
D006027:Glycosides; D007192:Indenes; C514853:cyanosporaside A; C514854:cyanosporaside B