[Oncolytic viral therapy for cancer therapy].
Recently, tumor-selective replicating viruses offer appealing advantages over conventional cancer therapy and are a promising new approach for the human cancer therapy. The development of oncolytic viral therapeutics is based on various strategies that each provides a different foundation for tumor-selective targeting and replication. Results from clinical trials of oncolytic viral therapy demonstrate the safety and feasibility of a new approach for cancer. Strategies to overcome various obstacles and challenges to this therapy are currently being searched. In the future, the development of oncolytic viral therapies will extend the range of tumors that can be treated using this novel treatment modality. In this paper, I would like to summarize the advances in the field including the findings from the viral treatment that we are currently utilizing.
Shimoyama
Satofumi
S
Department of Surgery II, Nagoya University Graduate School of Medicine.
Nakao
Akimasa
A
D000256:Adenoviridae; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D050130:Oncolytic Virotherapy; D018139:Simplexvirus