[The expression and activity of protein kinase A I in oral squamous cell carcinoma].
OBJECTIVE
To detect the expression and distribution of protein kinase A I (PKA I) in oral squamous cell carcinoma as well as its clinicalpathological significance.


METHODS
The expression of PKA I was investigated in 40 oral squamous cell carcinomas and 15 normal tissues by immunohistochemistry. The activity of PKAI was detected in 20 human oral squamous cell carcinomas and adjacent normal tissues with Western blot. The data was analysed with SPSS 11.5 for Student's t test, Chi-between different square test and linear correlation analysis.


RESULTS
The expression of PKA I was significantly higher in oral squamous cell carcinomas than in normal tissues (P<0.05). There were no differences degrees of histodifferentiation and clinical phases (P>0.05). The activity of PKA I was significantly higher in oral squamous cell carcinomas than in normal tissues (P<0.01), there were obvious dependability of the expression and activity of PKA I (P<0.01).


CONCLUSIONS
Protein kinase A I highly expressed in oral squamous cell carcinomas, but was not related to the degree of histodifferentiation and the clinical phases. Oral squamous cell carcinoma correlated with the expression and activity of PKA I and the activation of PKA I was one of the factors for proliferation of oral squamous cell carcinoma.
Qu
Chang-feng
CF
Department of Oral and Maxillofacial Surgery, Dalian Central Hospital, Dalian 116033, Liaoning Province, China.
Shang
De-hao
DH
Qi
Zhong-zheng
ZZ
Sun
Chang-fu
CF
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009062:Mouth Neoplasms / Q000378:metabolism*
D017868:Cyclic AMP-Dependent Protein Kinases