title: Accelerator mass spectrometry for quantitative in vivo tracing.
abstract: Accelerator mass spectrometry (AMS) counts individual rare, usually radio-, isotopes such as radiocarbon at high efficiency and specificity in milligram-sized samples. AMS traces very low chemical doses (micrograms) and radiative doses (100 Bq) of isotope-labeled compounds in animal models and directly in humans for pharmaceutical, nutritional, or toxicological research. Absorption, metabolism, distribution, binding, and elimination are all quantifiable with high precision after appropriate sample definition.
authors.affiliation: Lawrence Livermore National Laboratory, University of California, Livermore, CA 94551, USA. jsvogel@llnl.gov
authors.forename: John S
authors.initials: JS
authors.lastname: Vogel
mesh_terms: D000818:Animals; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D010315:Particle Accelerators; D011829:Radiation Dosage; D011868:Radioisotopes / Q000032:analysis* / Q000493:pharmacokinetics; D012680:Sensitivity and Specificity
chemical_list: D011868:Radioisotopes