[The incidence of some angiotensin-1 converting enzyme gene alleles in patients with coronary heart disease].
The results of several studies which have been published since 1992 evidence a significant correlation between DD genotype of angiotensin 1-converting enzyme (ACE) gene and development of coronary artery disease (CAD) in some populations. The authors of this article studied distribution of ACE gene I/D genotypes (II, ID, DD) in 102 patients with CAD and 50 controls without cardiovascular pathology or diabetes mellitus. The CAD diagnosis was confirmed by coronaroangiography. The study established a significant correlation between the presence of DD-ACE genotype and development of CAD. After exclusion of patients with classic risk factors (body mass index greater than 26 kg/m2; arterial hypertension; dislipidemia), this correlation remained. The results of the study demonstrate a significant positive correlation between the presence of DD genotype and high risk of CAD in this population, including people without such classic risk factors as obesity, arterial hypertension, or dislipidemia.
Istrati
V F
VF
Butorov
I V
IV
Manea
D V
DV
Ikim
A A
AA
Barbakar
N I
NI
Kalenich
O S
OS
Ikim
Iu M
IuM
Kalin
G V
GV
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics
D007703:Peptidyl-Dipeptidase A