title: Pleomorphic adenoma of the lacrimal gland in an 18-year-old girl irradiated for bilateral retinoblastoma.
abstract: OBJECTIVE
  To report a case of pleomorphic adenoma of the lacrimal gland following irradiation for bilateral retinoblastoma.
  
  
  METHODS
  Case report. A 4-month-old girl, with bilateral retinoblastoma, underwent enucleation of the right eye, systemic chemotherapy and bilateral external beam irradiation with a lateral field. The right anophthalmic socket (because of infiltration of the optic nerve) and the left eye (for relapse) were irradiated;. 17 years later, she developed a mass in the superotemporal quadrant of the left orbit. The mass was completely excised.
  
  
  RESULTS
  Pleomorphic adenoma is rare in children and teenagers; it usually presents as a painless, slow growing mass in healthy adults. In this case, it developed as a second primary tumor after irradiation for retinoblastoma.
authors.affiliation: Retinoblastoma Referral Center, University of Siena, Italy. hadjistililian@unisi.it
authors.forename: T
authors.initials: T
authors.lastname: Hadjistilianou
authors.forename: S
authors.initials: S
authors.lastname: de Francesco
authors.forename: C
authors.initials: C
authors.lastname: Signori
authors.forename: F
authors.initials: F
authors.lastname: Menicacci
authors.forename: P
authors.initials: P
authors.lastname: Galluzzi
authors.forename: P
authors.initials: P
authors.lastname: Toti
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D001707:Biopsy, Needle; D015353:Eye Enucleation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007765:Lacrimal Apparatus / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D019572:Retinal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D012175:Retinoblastoma / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D018570:Risk Assessment; D013997:Time Factors; D016896:Treatment Outcome