Anti-diabetic and hypolipidemic effects of aqueous-extract from the flower of Inula japonica in alloxan-induced diabetic mice.
The anti-diabetic and hypolipidemic effects of aqueous-extract from the flower of Inula japonica (IJ) and its two fractions (IJR and IJP) were investigated in alloxan-induced diabetic mice. An oral glucose tolerance test (OGTT) of IJ was also performed in normal and diabetic mice. The results showed that IJ (1000 mg/kg), IJR (500 mg/kg) and IJP (250 mg/kg) significantly reduced blood glucose levels in diabetic mice by oral administration (p<0.01). IJ and IJP markedly decreased serum triglyceride concentrations (p<0.05) in diabetic mice. Their hypoglycemic activities were better than gliclazide (40 mg/kg) and compared with metformin (250 mg/kg). IJ raised plasma insulin levels in alloxan-induced diabetic mice. IJ, IJR and IJP significantly decreased the consumption of water and food in diabetic mice. OGTT showed that IJ slightly lowered blood glucose levels in normal mice, but significantly decreased blood glucose in diabetic mice between 60-150 min after a glucose load (p<0.05). The data indicated that IJ has both anti-diabetic and hypolipidemic effects.
Shan
Jun-Jie
JJ
Beijing Institute of Pharmacology and Toxicology, People's Republic of China. shanjunjie001@sohu.com
Yang
Ming
M
Ren
Jin-Wei
JW
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D035264:Flowers / Q000737:chemistry; D005907:Gliclazide / Q000494:pharmacology; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007202:Indicators and Reagents; D007328:Insulin / Q000097:blood; D038143:Inula / Q000737:chemistry*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007202:Indicators and Reagents; D007328:Insulin; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol; D005907:Gliclazide