title: Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia.
abstract: A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, B.C. V6T 1Z1, Canada.
authors.forename: Roger G
authors.initials: RG
authors.lastname: Linington
authors.forename: Marilyn
authors.initials: M
authors.lastname: Robertson
authors.forename: Annick
authors.initials: A
authors.lastname: Gauthier
authors.forename: B Brett
authors.initials: BB
authors.lastname: Finlay
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
authors.forename: Rob
authors.initials: R
authors.lastname: van Soest
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017691:Caribbean Region; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010944:Plants / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D006017:Glycolipids; C469708:caminoside A; C508811:caminoside B; C508812:caminoside C; C508813:caminoside D