Beta 3 integrin expression on T cells from renal allograft recipients.
Recent studies emphasize the paramount significance of beta 3 integrin in cell adhesion and homing, which may be particularly relevant in cancer progression and metastasis. In contrast, the presence and potential role of beta 3 on human T cells is practically unknown. We show that T cells can express significant amounts of alpha-beta 3 integrin (CD41/CD61), and the expression of alpha(v)-beta 3 (CD51/CD61) remains very low. T-cell beta 3 integrin is probably transferred by platelet-derived microparticles.
Wierzbicki
P
P
Transplantation Institute, Warsaw Medical University, ul. Nowogrodzka 59, 02-006 Warsaw, Poland. wieslawa_lojek@poczta.onet.pl
Kłosowska
D
D
Wyzgał
J
J
Nowaczyk
M
M
Przerwa
A
A
Kniotek
M
M
Górski
A
A
D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D016030:Kidney Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D015703:Antigens, CD; D039661:Integrin beta3