title: Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years.
abstract: BACKGROUND
  Appropriate use of prebiotics and optimal combinations of probiotics and prebiotics (synbiotics) could allow significantly better results to be obtained in the treatment of atopic dermatitis (AD).
  
  
  OBJECTIVE
  To evaluate the efficiency of synbiotics when compared with prebiotics alone (control group) in the treatment of moderate and severe AD in children aged 2 years and over.
  
  
  METHODS
  Double-blind prospective randomized study performed on children aged at least 2 years presenting AD with a minimum SCORing Atopic Dermatitis (SCORAD) score of 15. A dose of 1.2 x 10(9) colony-forming units Lactobacillus rhamnosus Lcr35 plus prebiotic preparation or an identically appearing prebiotic preparation alone was given three times a day for 3 months. Patients' diet and usual treatment for AD remained unchanged during the study period. Efficiency was evaluated using the SCORAD score. Use of topical drugs was noted.
  
  
  RESULTS
  A total of 48 patients were originally enrolled; nine did not complete the study. In synbiotic group, the mean values of the total SCORAD score was 39.1 before treatment vs 20.7 after 3 months of treatment (P < 0.0001). In the prebiotic group, the mean of the total SCORAD score was 39.3 before the treatment vs 24.0 after 3 months (P < 0.0001). After 3 months of treatment, no statistical differences between the two treatment groups with regard to the total SCORAD score were noted (P = 0.535). Neither were there any statistical differences in the total use of ointment between patients receiving prebiotics or synbiotics (P = 0.966) over the study period. Tolerance was excellent in both groups.
  
  
  CONCLUSIONS
  Both synbiotics and prebiotics used alone seem able to significantly improve the manifestations of AD in children aged 2 years and over.
authors.affiliation: Department of Dermatology, CHU de Nice, Nice, France.
authors.forename: T
authors.initials: T
authors.lastname: Passeron
authors.forename: J-P
authors.initials: JP
authors.lastname: Lacour
authors.forename: E
authors.initials: E
authors.lastname: Fontas
authors.forename: J-P
authors.initials: JP
authors.lastname: Ortonne
mesh_terms: D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000628:therapy*; D004311:Double-Blind Method; D006801:Humans; D052201:Lacticaseibacillus rhamnosus; D019936:Probiotics / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies