Interactions of chemicals and metal ions with proteins and role for immune responses.
Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.
Martin
Stefan F
SF
Department of Dermatology, Clinical Research Group Allergology University of Freiburg, D-79104 Freiburg, Germany. stefan.martin@uniklinik-freiburg.de
Merfort
Irmgard
I
Thierse
Hermann-Josef
HJ
D000485:Allergens / Q000276:immunology*; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D006241:Haptens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007477:Ions / Q000276:immunology; D008670:Metals / Q000276:immunology* / Q000378:metabolism; D009532:Nickel / Q000276:immunology; D011485:Protein Binding; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D040901:Proteomics
D000485:Allergens; D006241:Haptens; D007477:Ions; D008670:Metals; D011506:Proteins; D009532:Nickel