title: Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
abstract: We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.
authors.affiliation: Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, Georgia 30322, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Cardona
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Korbutt
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Milas
authors.forename: James
authors.initials: J
authors.lastname: Lyon
authors.forename: Jose
authors.initials: J
authors.lastname: Cano
authors.forename: Wanhong
authors.initials: W
authors.lastname: Jiang
authors.forename: Hameeda
authors.initials: H
authors.lastname: Bello-Laborn
authors.forename: Brad
authors.initials: B
authors.lastname: Hacquoil
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Strobert
authors.forename: Shivaprakash
authors.initials: S
authors.lastname: Gangappa
authors.forename: Collin J
authors.initials: CJ
authors.lastname: Weber
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Pearson
authors.forename: Ray V
authors.initials: RV
authors.lastname: Rajotte
authors.forename: Christian P
authors.initials: CP
authors.lastname: Larsen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D064987:Cell- and Tissue-Based Therapy; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D007515:Islets of Langerhans / Q000166:cytology / Q000276:immunology; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D008251:Macaca / Q000276:immunology*; D010180:Pancreatectomy; D013552:Swine / Q000276:immunology; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000276:immunology