Phytochemical composition of essential oil from seeds of Zingiber roseum Rosc. and its antispasmodic activity in rat duodenum.
A combination of GC and GC-MS revealed the presence of 60 compounds out of which 47 compounds (96.2% of the oil) were identified in the essential oil of seeds of Zingiber roseum Rosc., the major compounds being alpha-pinene, beta-pinene, limonene, p-cymene, alpha-terpineol and verticiole. The unique feature is the dominant presence of mono- and sesquiterpene hydrocarbons which make about 82% of the oil. The oil showed myorelaxant activity on isolated rat duodenal smooth muscle. The Zingiber roseum seed essential oil (ZRSEO) relaxed both cabachol- and KCl-induced contractile responses with IC(50) of non-significant difference. The results confirm a common mechanism in both the types of action of ZRSEO and suggests a probable inhibitory effect of ZRSEO on influx of Ca(2+) through cell membrane of rat duodenal smooth muscle.
Prakash
Om
O
Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar 263 145, Uttaranchal, India. op_orgchem@yahoo.co.in
Kasana
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VK
Pant
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Zafar
Anjum
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Hore
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Mathela
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D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004386:Duodenum / Q000187:drug effects*; D005638:Fruit; D020128:Inhibitory Concentration 50; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012639:Seeds; D030521:Zingiberaceae
D000930:Antidiarrheals; D010938:Plant Oils