Childhood trauma and personality disorder: toward a biological model.
Cross-sectional and prospective associations of personality disorder with childhood trauma provide an important clue regarding the biological mechanism of personality disorder. In this review, empirical literature from several domains is summarized. These include relevant findings from behavioral genetics, preclinical models of early life parental care, and clinical translational studies of personality disorder. Identification of the biological mechanism by which childhood trauma exerts an effect on personality disorder may require modification of the conceptualization of personality disorder, either as a set of categories or dimensions.
Lee
Royce
R
The University of Chicago, Department of Psychiatry, 5841 S. Maryland Avenue, Chicago, IL 60613, USA. rlee@yoda.bsd.uchicago.edu
D000818:Animals; D001921:Brain / Q000503:physiopathology; D002648:Child; D002649:Child Abuse / Q000523:psychology* / Q000706:statistics & numerical data; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008016:Life Change Events; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000502:physiology; D010554:Personality Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D012307:Risk Factors; D012931:Social Environment; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology
D018377:Neurotransmitter Agents; D003346:Corticotropin-Releasing Hormone