title: Antidepressant efficacy of olanzapine as monotherapy in major depressive disorder, without psychosis: a pilot study.
abstract: In this pilot study we assessed the efficacy of olanzapine as monotherapy in the treatment of major depressive disorder, without psychosis. We also demonstrated the in vivo 5-HT2A receptor occupancy of olanzapine using positron emission tomography. An open-label prospective 6-week study design with 14 patients who met the inclusion and exclusion criteria for the study were enrolled from the general community of the St. Louis metropolitan area. All patients met DSM-IV criteria for major depressive disorder without psychosis, had a Hamilton Depression Rating Scale (HAMD17) score >18 and were between the ages of 18 and 65. The primary measure of efficacy was the change in HAMD 17 total score from baseline to endpoint. The data were collected between 1998 and 2004. There was a significant reduction in the HAMD17 scores from baseline to endpoint. Half the patients (n=6) showed > or =50% reduction in their HAMD17 scores. This study points to the potential of olanzapine as a therapeutic agent for the treatment of major depressive disorder without psychosis.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S. Euclid, St. Louis, MO 63110, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Mathews
authors.forename: Keith S
authors.initials: KS
authors.lastname: Garcia
authors.forename: Mark A
authors.initials: MA
authors.lastname: Mintun
authors.forename: Yvette I
authors.initials: YI
authors.lastname: Sheline
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D012720:Severity of Illness Index
chemical_list: D000928:Antidepressive Agents; D044402:Receptor, Serotonin, 5-HT2A; D001569:Benzodiazepines; D000077152:Olanzapine