title: Surgery results in significant improvement in growth in children with Crohn's disease refractory to medical therapy.
abstract: Inflammatory bowel disease (IBD) in children can cause significant impairment in linear growth, and delay in pubertal onset. The aim of this study was to assess the impact of surgery on linear growth in children with Crohn's disease (CD) who were resistant to medical therapy, and had documented evidence of growth impairment. We performed a retrospective study on eight consecutive patients with refractory disease who had attended the paediatric IBD clinic. All patients underwent surgery as part of their treatment. Height and weight were recorded at least 6 months prior to surgery, at the time of surgery, and 6 months post surgery. Growth velocities and height Z-scores were calculated. All patients had evidence of sustained growth suppression prior to surgery. Three patients had evidence of growth failure. There was a significant increase in height velocity from 0.15 cm/month before surgery to 0.54 cm/month after surgery (P = 0.006). There was also a significant decrease in the modified Harvey-Bradshaw index (HBI) of disease activity from 2.00 before surgery, to 0.84 after surgery (P = 0.003). Improvements in height Z-score and weight velocity after surgery were not significant on statistical analysis. Our study demonstrates that before surgery, children with CD refractory to therapy have sustained growth suppression, and in some cases may even have growth failure. Surgical intervention before puberty appears to result in a significant improvement in height velocity and disease activity. These findings need to be further investigated with carefully designed prospective studies.
authors.affiliation: Academic Department of Colorectal Surgery, St. George's Hospital Medical School, Blackshaw Road, Tooting, SW17 0QT, London, UK. gsinghranger@yahoo.co.uk
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Singh Ranger
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lamparelli
authors.forename: Andrew
authors.initials: A
authors.lastname: Aldridge
authors.forename: Sonny K
authors.initials: SK
authors.lastname: Chong
authors.forename: Sally G
authors.initials: SG
authors.lastname: Mitton
authors.forename: Assunta
authors.initials: A
authors.lastname: Albanese
authors.forename: Devinder
authors.initials: D
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D001827:Body Height; D001835:Body Weight; D002648:Child; D002657:Child Development; D003424:Crohn Disease / Q000150:complications / Q000601:surgery*; D004351:Drug Resistance; D006130:Growth Disorders / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors