title: Prognosis of small thyroid cancer in patients with Graves' disease.
abstract: BACKGROUND
  To find the best ways to follow up patients with small thyroid cancer (STC; 1 cm or less in diameter) and concomitant Graves' disease, this study examined whether such patients had the same excellent prognosis as those with STC without Graves' disease.
  
  
  METHODS
  Between 1970 and 1996, 2199 patients were diagnosed as having STC by pathology after thyroidectomy. Of those, 509 patients (33 males and 476 females, mean age 43.5 years) underwent thyroidectomy for Graves' disease. Control patients with STC without Graves' disease were matched for age, sex, treatment year and tumour size (33 males and 476 females, mean age 44.0 years).
  
  
  RESULTS
  Patients with STC and Graves' disease had a longer disease-free survival than those with STC alone (99 and 93 per cent at 20 years' follow-up, respectively; P < 0.001). The Cox's proportional hazard analysis showed that concomitant Graves' disease and age at surgery are more significant factors for predicting disease-free survival than surgical procedures.
  
  
  CONCLUSIONS
  Patients who undergo thyroidectomy for Graves' disease and are found to have STC have an excellent prognosis and longer disease-free survival than patients with STC alone.
authors.affiliation: Japanese Self Defense Force Hanshin Hospital, Hyogo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kikuchi
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Uchino
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000150:complications / Q000401:mortality / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods / Q000401:mortality