title: Basal cell-signet-ring squamous cell carcinoma of the eyelid.
abstract: A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fleshy, fungating growth involving more than 60% of the right lower eyelid. Excisional biopsy disclosed a neoplasm arising from the epidermis composed of adjoining basal cell and signet-ring squamous cell carcinoma, without a transition zone. The cells comprising the basal and squamous cell carcinomas were distinct immunophenotypically, with only the basal cell carcinoma reacting with Ber-EP4 and CAM 5.2 antibodies. To our knowledge, this case represents the first example of a collision tumor composed of basal cell and signet-ring squamous cell carcinoma.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. proia001@mc.duke.edu
authors.forename: Alan D
authors.initials: AD
authors.lastname: Proia
authors.forename: M Angelica
authors.initials: MA
authors.lastname: Selim
authors.forename: Jason C
authors.initials: JC
authors.lastname: Reutter
authors.forename: John J
authors.initials: JJ
authors.lastname: Michon
mesh_terms: D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018279:Carcinoma, Signet Ring Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D009378:Neoplasms, Multiple Primary; D016896:Treatment Outcome; D000951:Antigens, Neoplasm
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D007633:Keratins; C400901:CAM 5.2 antigen; C115012:human epithelial antigen-125; D000951:Antigens, Neoplasm