Aotus nancymaae as a potential model for the testing of anti-sporozoite and liver stage vaccines against Plasmodium falciparum.
The Santa Lucia strain of Plasmodium falciparum was transmitted to Aotus lemurinus griseimembra, A. azarae boliviensis, A. vociferans, and A. nancymaae monkeys by bite and by intravenous inoculation of sporozoites dissected from Anopheles freeborni, An. stephensi, An. gambiae, An. albimanus, and An. maculatus mosquitoes. The data obtained from these infections indicate that A. nancymaae can be considered a suitable host model when combined with the Santa Lucia strain of P. falciparum for the testing of candidate anti-sporozoite and liver stage vaccines.
Collins
William E
WE
Division of Parasitic Diseases and Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. wec1@cdc.gov
Sullivan
Joann S
JS
Williams
Allison
A
Nace
Douglas
D
Williams
Tyrone
T
Galland
G Gale
GG
Barnwell
John W
JW
D000818:Animals; D016645:Aotidae; D004195:Disease Models, Animal; D008099:Liver / Q000469:parasitology; D017780:Malaria Vaccines / Q000276:immunology* / Q000494:pharmacology*; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D034101:Sporozoites / Q000276:immunology
D017780:Malaria Vaccines