title: [Incidence of multiple (second) primary tumors of head and neck following tobacco smoking].
abstract: A review presents an incidence of multiple (second) primary tumors of head and neck region resulted from an exposure to tobacco smoke and ethanol. Further, epidemiology, clinical implications, molecular alterations and an impact of genetic factor are described. Finally, alternative theories of origin of multiple primary tumors are discussed.
authors.affiliation: Instytut Genetyki Człowieka PAN, Poznań. szyfkris@man.poznan.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wierzbick
authors.forename: Maciej
authors.initials: M
authors.lastname: Giefing
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rydzanicz
mesh_terms: D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology; D011044:Poland / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology*