Early follicular antimüllerian hormone as an indicator of ovarian reserve.
OBJECTIVE
To determine the predictive value of antimüllerian hormone (AMH) as a marker for ovarian reserve and to compare its value with the markers currently being used.


METHODS
Prospective analysis.


METHODS
In vitro fertilization (IVF) clinic of a tertiary medical center.


METHODS
Fifty women undergoing assisted reproduction cycles.


METHODS
None.


METHODS
Comparison of day-3 serum AMH levels among women with less than five retrieved oocytes and five or more oocytes. Antral follicle count, mature oocyte count, age, basal follicle-stimulating hormone (FSH), estradiol (E2), maximum serum E2 levels, and pregnancy success were also compared.


RESULTS
The mean serum AMH levels of patients with more than five retrieved oocytes were found to be higher (0.67 +/- 0.41 vs. 0.15 +/- 0.11 pg/mL). Mature oocyte counts, antral follicle counts, and maximum E2 levels were found to be statistically significantly different in the two groups despite similar ages and levels of basal FSH and E2. Although the receiver operator characteristics analysis revealed that the most sensitive and specific indicator of ovarian reserve is the level of AMH, it does not indicate pregnancy success as well when 0.25 pg/mL is taken as a cut-off value.


CONCLUSIONS
These data demonstrate an association between early follicular serum AMH and ovarian response, but no association with pregnancy success.
Fiçicioglu
Cem
C
IVF Clinic, Zeynep Kamil Women's and Children's Hospital, Istanbul, Turkey.
Kutlu
Tayfun
T
Baglam
Elif
E
Bakacak
Zeynep
Z
D000328:Adult; D054304:Anti-Mullerian Hormone; D002452:Cell Count; D016922:Cellular Senescence; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000627:therapeutic use; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D008597:Menstrual Cycle / Q000097:blood; D009865:Oocytes / Q000473:pathology; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000378:metabolism*; D010050:Ovarian Function Tests; D010053:Ovary / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012372:ROC Curve; D011859:Radiography; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D013735:Testicular Hormones / Q000097:blood / Q000378:metabolism*; D014463:Ultrasonography
D006023:Glycoproteins; D011994:Recombinant Proteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone