Penifulvin A: a sesquiterpenoid-derived metabolite containing a novel dioxa[5,5,5,6]fenestrane ring system from a fungicolous isolate of Penicillium griseofulvum.
[structure: see text] Penifulvin A (1), a new fungal metabolite with a previously undescribed ring system, has been isolated from cultures of an isolate of Penicillium griseofulvum (NRRL 35584) obtained from a white mycelial growth on a dead hardwood branch collected in a Hawaiian forest. The structure was assigned by analysis of NMR data and confirmed by single-crystal X-ray diffraction analysis. Penifulvin A (1) shows significant activity in dietary assays against the fall armyworm Spodoptera frugiperda.
Shim
Sang Hee
SH
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Swenson
Dale C
DC
Gloer
James B
JB
Dowd
Patrick F
PF
Wicklow
Donald T
DT
D000818:Animals; D018360:Crystallography, X-Ray; D006254:Hawaii; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018411:Spodoptera / Q000187:drug effects*
D012717:Sesquiterpenes; C515096:penifulvin A