title: Nasal and oral masses in a dog.
abstract: A 5-year-old, intact male, stray dog was presented in poor body condition, with pallor, muzzle deformity, multiple oozing fistulas with grass awns, bilateral sanguinopurulent nasal discharge and a fleshy friable mass occupying part of the hard palate. A friable mass occupying both nasal cavities was found on rhinoscopy. The dog had moderate nonregenerative normochromic-microcytic anemia, thrombocytopenia, hyperglobulinemia, and hypoalbuminemia. Cytologic preparations of the nasal and oral masses contained a neoplastic population of round cells with intracytoplasmic and extracellular vacuoles. Leishmania amastigotes also were observed, in the cytoplasm of macrophages and, occasionally, within neoplastic cells. A diagnosis of transmissible venereal tumor and concurrent leishmaniosis was made. Treatment with vincristine and allopurinol resulted in complete resolution of clinical signs and disappearance of the masses. The presence of amastigotes in neoplastic TVT cells may suggest an alternative mode of transmission of canine leishmaniosis where these diseases co-exist.
authors.affiliation: Veterinary Center of Thessaloniki, School of Veterinary Medicine, Aristotle Univiersity of Thessaloniki, Greece.
authors.forename: Esther
authors.initials: E
authors.lastname: Levy
authors.forename: Mathios E
authors.initials: ME
authors.lastname: Mylonakis
authors.forename: Manolis N
authors.initials: MN
authors.lastname: Saridomichelakis
authors.forename: Zoe S
authors.initials: ZS
authors.lastname: Polizopoulou
authors.forename: Vassilios
authors.initials: V
authors.lastname: Psychogios
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Koutinas
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D007896:Leishmaniasis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009059:Mouth Diseases / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D009668:Nose Diseases / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*