Androgenic adult granulosa cell tumor in a teenager: a case report and review of the literature.
The clinicopathologic findings of the third case of androgenic adult granulosa cell tumor in patients younger than 15 years was presented and discussed in the light of the literature. A patient complaining of secondary amenorrhea and hirsutism with elevated levels of plasma total testosterone, dehydroepiandrosterone sulfate, free androgen index and serum inhibin A, and a left ovarian septated, cystic mass was admitted to the hospital. The inhibin A level was within normal levels in the first month postoperatively. Inhibin A could be a tumor marker of utmost importance particularly in patients with androgenic or hyperestrogenic symptoms, especially in cases where benign criteria are abundant such as young age, nonincreased levels of classic tumor markers, and ultrasonographic appearance without any suspicion of malignancy.
Kabaca
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Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education And Research Hospital, Uskudar, Istanbul, Turkey. canankabaca@yahoo.com
Karateke
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Gurbuz
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Cesur
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S
D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology; D000728:Androgens / Q000097:blood; D000737:Androstenols / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013509:Gynecologic Surgical Procedures; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D007265:Inhibins / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery
D000728:Androgens; D000737:Androstenols; D014408:Biomarkers, Tumor; C422362:inhibin A; D007265:Inhibins