Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus.
Bitriazolyl compounds were synthesized and their activity against tobacco mosaic virus was assessed. Two of them showed promising antiviral activity and were more potent than the reference compounds. Moreover, these compounds are predicted not to be carcinogenic or mutagenic based on the prediction systems. Therefore, the bitriazolyl compounds may provide interesting new leads or scaffolds for use in further attempts to screen novel antiviral candidates.
Xia
Yi
Y
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
Fan
Zhijin
Z
Yao
Jianhua
J
Liao
Quan
Q
Li
Wei
W
Qu
Fanqi
F
Peng
Ling
L
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology
D000998:Antiviral Agents; D014230:Triazoles