Cell and molecular mechanisms involved in the migration of cortical interneurons.
Since the discovery that the vast majority of the GABA-containing interneurons of the cerebral cortex arise in the subpallium, considerable effort has been put into the description of the precise origin of these neurons in subdivisions of the ganglionic eminence and in the migratory routes they follow on their way to the developing cortex. More recently, studies have focused on the molecular and cellular mechanisms that guide their migration. Investigations of the molecular mechanisms involved have demonstrated important roles for numerous transcription factors, motogenic factors and guidance molecules. Here, we review results of very recent analyses of the underlying cellular mechanisms and specifically of the movement of the nucleus, cytoplasmic components and neuritic processes during interneuron migration.
Métin
Christine
C
Developpement Normal et Pathologique du Cerveau, INSERM, U616, 47 Boulevard de l'Hôpital, F-75651 Paris Cédex 13, France.
Baudoin
Jean-Pierre
JP
Rakić
Sonja
S
Parnavelas
John G
JG
D000818:Animals; D002465:Cell Movement / Q000235:genetics*; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D008870:Microtubules / Q000502:physiology; D008954:Models, Biological; D024462:Myosin Type II / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000235:genetics / Q000378:metabolism
D014157:Transcription Factors; D005680:gamma-Aminobutyric Acid; D024462:Myosin Type II