Biocompatibility testing of branched and linear polyglycidol.
Polyglycidols are flexible hydrophilic polyethers that are potentially biocompatible polymers based on their similarities to the well-studied poly(ethyleneglycol). Polyglycidols can be prepared as branched or linear polymers by suitable synthetic methods. Biocompatibility testing of these polymers conducted in vitro as well as in vivo are reported here. The in vitro studies included hemocompatibility testing for effects on coagulation (PT and APTT), complement activation, red blood cell aggregation, and whole blood viscosity measurements. In vitro cytotoxicity experiments were also conducted. The results were compared with some of the common biocompatible polymers already in human use. Results from these studies show that polyglycidols are highly biocompatible. Hyperbranched polyglycidols were found to be well tolerated by mice even when injected in high doses.
Kainthan
Rajesh Kumar
RK
Department of Pathology and Laboratory Medicine, Chemistry and Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Janzen
Johan
J
Levin
Elena
E
Devine
Dana V
DV
Brooks
Donald E
DE
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001780:Blood Coagulation Tests; D001809:Blood Viscosity; D004305:Dose-Response Relationship, Drug; D004987:Ethers / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D046911:Macromolecular Substances / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D015539:Platelet Activation / Q000187:drug effects; D011108:Polymers / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry*; D014471:Umbilical Veins / Q000166:cytology
D001672:Biocompatible Materials; D004987:Ethers; D046911:Macromolecular Substances; D011108:Polymers; D011409:Propylene Glycols; C502907:polyglycidol