Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia and severe sepsis.
The triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule involved in the inflammatory response. It belongs to the immunoglobulin superfamily and is expressed on the surface of neutrophils, mature monocytes, and macrophages. The engagement of TREM-1 synergizes with the Toll-like receptors signaling pathway in amplifying the inflammatory response mediated by several microbial components. The expression of the membrane-bound TREM-1 is strongly upregulated on monocytes during sepsis. Besides its membranous form, a soluble counterpart of TREM-1 exists that is specifically released during several infectious processes. The measurement of that soluble form in biological fluids may be useful as a diagnostic tool, especially during severe sepsis and pneumonia. Moreover, the evolutionary pattern of TREM-1 may be interesting during the follow-up of septic patients.
Gibot
Sébastien
S
Service de Réanimation Médicale, Hôpital Central, Nancy Cedex, France. s.gibot@chu-nancy.fr
D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*; D018805:Sepsis / Q000175:diagnosis* / Q000378:metabolism; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1