title: Outcome and effect of pregnancy in myotonic dystrophy type 2.
abstract: The authors reviewed the obstetric histories of 42 women of 37 families with myotonic dystrophy type 2 (DM2). Nine women (21%) had the first symptoms during pregnancy and worsening in subsequent pregnancies. Of 96 pregnancies, 13% ended as early and 4% as late miscarriages. Preterm labor occurred in 50% of pregnancies resulting in 27% preterm deliveries in women with overt DM2 in pregnancy. There was no evidence of a congenital DM2.
authors.affiliation: Institute for Human Genetics, RWTH Aachen University, Aachen, Germany. srudnik-schoeneborn@ukaachen.de
authors.forename: S
authors.initials: S
authors.lastname: Rudnik-Schöneborn
authors.forename: C
authors.initials: C
authors.lastname: Schneider-Gold
authors.forename: U
authors.initials: U
authors.lastname: Raabe
authors.forename: W
authors.initials: W
authors.lastname: Kress
authors.forename: K
authors.initials: K
authors.lastname: Zerres
authors.forename: B G H
authors.initials: BG
authors.lastname: Schoser
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D009154:Mutation; D009223:Myotonic Dystrophy / Q000235:genetics / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011256:Pregnancy Outcome; D016601:RNA-Binding Proteins / Q000235:genetics
chemical_list: C433227:CNBP protein, human; D016601:RNA-Binding Proteins