title: Aripiprazole in the management of post-traumatic stress disorder symptoms in returning Global War on Terrorism veterans.
abstract: The present study illustrates the potential use of aripiprazole as part of the management of post-traumatic stress disorder (PTSD) in returning Global War on Terrorism (GWOT) veterans. Five consecutive cases of GWOT combat-related PTSD, managed in part with the atypical antipsychotic medication aripiprazole, are presented and discussed. In four of the five cases reported, the medication was well-tolerated and was effective in the management of sleep disturbances, such as nightmares and agitated behaviours during sleep, and was also helpful in the management of hyper-arousal. In one case, the veteran experienced a paradoxical excitation response to the medication. Aripiprazole, in conjunction with other medications or psychotherapeutic interventions, should be studied further for its potential role in the management of PTSD.
authors.affiliation: Department of Psychiatry, University of Texas South-Western Medical School at Dallas (UTSWMS), Texas 76104, USA. michael.lambert2@med.va.gov
authors.forename: Michael Tedford
authors.initials: MT
authors.lastname: Lambert
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D000068180:Aripiprazole; D003130:Combat Disorders / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000188:drug therapy*; D023481:Terrorism / Q000517:prevention & control; D016896:Treatment Outcome; D014728:Veterans; D014857:Warfare
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole