title: High prevalence of penicillin resistance and comparative in vitro activity of various antibiotics in clinical isolates of streptococcus pneumoniae isolated in the Province of Hainaut during winter 2004.
abstract: A total of 154 isolates of Streptococcus pneumoniae obtained from 8 different centres in the province of Hainaut were included in this study. The susceptibilities to penicillin, amoxicillin, cefuroxime, ciprofloxacin, moxifloxacin, erythromycin and tetracycline were determined by a microdilution technique following NCCLS recommendations. Decreased susceptibility to penicillin was 32.5% (23.4% intermediate and 9.1% high-level). The other insusceptibility rates were as follows: amoxicillin 1.9% [0% Resistance (R)], cefuroxime 23.4% (R 22.1%), ciprofloxacin 9.1% (R 1.3%), erythromycin 39.6% (R 38.3%), and tetracycline 31.8% (R 30.5%). No decreased susceptibility was found for moxifloxacin. MICs of amoxicillin, cefuroxime, erythromycin and tetracycline rose with those of penicillin for penicillin-insusceptible isolates. Most penicillin-insusceptible isolates remained fully susceptible to amoxicillin (94%), while moxifloxacin and ciprofloxacin kept an activity on 100% and 92% of these isolates respectively. Phenotypes with triple or quadruple insusceptibility were present in 31.2% of the isolates. Penicillin-insusceptible isolates showed a co-insusceptibility of 36.7% to erythromycin, 30.0% to tetracycline and 3.3% to ciprofloxacin.
authors.affiliation: Pasteurinstituut, Brussel, Eenheid Antibiotica-Onderzoek, Engelandstraat 642, B-1180 Brussel. rvanhoof@pasteur.be
authors.forename: R
authors.initials: R
authors.lastname: Vanhoof
authors.forename: J
authors.initials: J
authors.lastname: Brouillard
authors.forename: S
authors.initials: S
authors.lastname: Damée
authors.forename: N
authors.initials: N
authors.lastname: d'Hondt
authors.forename: A
authors.initials: A
authors.lastname: Haccourt
authors.forename: I
authors.initials: I
authors.lastname: Mansoor
authors.forename: J F
authors.initials: JF
authors.lastname: Marchal
authors.forename: I
authors.initials: I
authors.lastname: Philippart
authors.forename: F
authors.initials: F
authors.lastname: Trigaux
authors.forename: B
authors.initials: B
authors.lastname: Van Bosterhaut
authors.forename: C
authors.initials: C
authors.lastname: Rossi
authors.forename: E
authors.initials: E
authors.lastname: Van Bossuyt
mesh_terms: D000293:Adolescent; D000328:Adult; D001530:Belgium; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010403:Penicillin Resistance; D010865:Pilot Projects; D015995:Prevalence; D013296:Streptococcus pneumoniae