[Experimental pathological study of acute intoxication by Chloranthus serratus Roem. Et Schalt].
OBJECTIVE
To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.


METHODS
Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem. et Schalt followed by pathological, serum biochemical, and coagulation mechanism examination.


RESULTS
The LD50 in mice was 41.12 g/kg; All poisoned mice serum BUN and ALT increased markedly; Thrombocyte decreased and coagulation time increased; The organ index of liver, spleen and kidneys increased significantly; The cells of liver, kidney and heart were degeneration and necrosis, There were extensive hyperemia and hemorrhage in many organs.


CONCLUSIONS
The experiment suggests that the target organs were liver, kidney, heart and blood vessels; The toxic mechanism was the damage on the mitochondrional, endoplasmic reticulum and coagulation system.
Zhang
Wu
W
Department of Forensic Pathology,Wannan Medical College, Wuhu 241001,China.
Zhu
Jian-hua
JH
Cheng
Li-bao
LB
Li
Yong-hong
YH
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005260:Female; D049429:Forensic Pathology; D007668:Kidney / Q000473:pathology*; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology*; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D008929:Mitochondria, Heart / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D009206:Myocardium / Q000473:pathology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D011897:Random Allocation
D015415:Biomarkers; D010936:Plant Extracts