title: Treatment of primary progressive freezing of gait with high doses of selegiline.
abstract: We report the case of a 76-year-old, right-handed woman with progressive primary freezing of gait. Despite several therapeutic strategies, she continued to worsen to the point that she became confined to a wheelchair. Treatment with selegiline in doses up to 20 mg/d led to marked improvement of the gait disorder. This case illustrates that selegiline can be an option for patients with freezing of gait other than those with Parkinson's disease.
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Zúñiga
authors.forename: Jacobo
authors.initials: J
authors.lastname: Lester
authors.forename: María Graciela
authors.initials: MG
authors.lastname: Cersósimo
authors.forename: Sergio
authors.initials: S
authors.lastname: Díaz
authors.forename: Federico E
authors.initials: FE
authors.lastname: Micheli
mesh_terms: D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects*; D020233:Gait Disorders, Neurologic / Q000188:drug therapy*; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012642:Selegiline / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D012642:Selegiline