Hypertension, race, and glomeruli: more than simply a numbers game.
Incidences of hypertension and hypertension-related renal failure are considerably higher in African-Americans than in white Americans. One explanation offered for this is that African-Americans have a higher incidence of low birth weight, the latter associated with lower numbers of glomeruli. However, although studies show a clear association between hypertension and glomerular number in whites, the situation in African-Americans appears more complex.
Haas
M
M
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. mhaas@jhmi.edu
D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000368:Aged; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology*; D006977:Hypertension, Renal / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007678:Kidney Glomerulus / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation; D051437:Renal Insufficiency / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology; D012964:Sodium / Q000652:urine; D044465:White People
D012964:Sodium