[Comparative study about the specific antileishmania of immunoglobulin G and E as markers of infection and illness among dwellers of a visceral leishmaniasis endemic area in São Luis, MA].
Comparative study regarding IgG and IgE anti-leishmania as markers of infection and illness among residents of a visceral leishmaniasis visceral leishmaniasis endemic area, São Luis, MA in the period from May 1999 to May 2000. All the 1,016 individuals younger than 16 years old were tested for the presence of IgG by ELISA. A total of 174 (17.1%) children revealed a positive IgG test and 4 children showed symptoms of classical visceral leishmaniasis during the time of the survey: 85 IgE anti-leishmania ELISA tests with positivity of 43.5% were realized. In this sample, all 7 children with past-visceral leishmaniasis in the sample were IgG positive and 4 (57.1%) were IgE positive, even after a 7 year post treatment period. Three children with current visceral leishmaniasis were evaluated, and all of them were positive for both tests. The detection of antileishman IgE antibodies presented as a good marker for infection by Leishmania chagasi in endemic areas but not as a disease marker.
Nascimento
Maria do Desterro Soares Brandão
Mdo D
Departamento de Patologia, Universidade Federal do Maranhão, São Luís, MA. cnsd_ma@uol.com.br
Bezerra
Geusa Felipa de Barros
GF
Bandeira Neto
Abderval Pinto
AP
Silva
Leopoldo Muniz da
LM
Bezerra
José de Macêdo
Jde M
Viana
Graça Maria de Castro
GM
D000293:Adolescent; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases; D004797:Enzyme-Linked Immunosorbent Assay; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D018314:Leishmania infantum / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male
D015415:Biomarkers; D007074:Immunoglobulin G; D007073:Immunoglobulin E