[Association between high activity of DNA polymerase iota and the development of human uveal melanoma].
Enzymatic activity of DNA polymerase iota (Pol t) was analyzed in human uveal melanoma cell extracts, using an earlier elaborated approach. The Pol t activity was observed in seven out of eight malignant tumors, while it was absent in the normal uveal tract cells of the same patients. These findings serve as an additional confirmation of the Pol t oncogenic potential.
Gening
L V
LV
Grishina
E E
EE
Petrochenkov
A N
AN
Tarantul
V Z
VZ
D000368:Aged; D014408:Biomarkers, Tumor; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D003838:Deoxyadenine Nucleotides / Q000737:chemistry; D003848:Deoxyguanine Nucleotides / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005123:Eye / Q000098:blood supply / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000201:enzymology*; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000201:enzymology*; D000094769:DNA Polymerase iota
D014408:Biomarkers, Tumor; D003838:Deoxyadenine Nucleotides; D003848:Deoxyguanine Nucleotides; C029603:deoxyguanosine triphosphate; D004259:DNA-Directed DNA Polymerase; C026600:2'-deoxyadenosine triphosphate; D000094769:DNA Polymerase iota; C000722070:POLI protein, human