title: Prolonged cholestasis associated with short-term use of celecoxib.
abstract: Drug-induced liver injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported. We describe one case of severe and prolonged cholestasis after treatment with celecoxib for 12 days in a young woman with no evidence of other causes of liver disease or allergy. Jaundice lasted for 3 months, pruritus and abnormal liver biochemistry persisted for 18 months after stopping the drug. Liver biopsy specimens showed a cholestatic pattern of liver injury with only minimal mononuclear infiltrate in the portal tracts. This case report supports the notion that celecoxib may cause bland, long term cholestasis.
authors.affiliation: Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpital de Hautepierre. Patrick.Chamouard@chru-strasbourg.fr
authors.forename: Patrick
authors.initials: P
authors.lastname: Chamouard
authors.forename: Paul
authors.initials: P
authors.lastname: Walter
authors.forename: René
authors.initials: R
authors.lastname: Baumann
authors.forename: Raoul
authors.initials: R
authors.lastname: Poupon
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000068579:Celecoxib; D002779:Cholestasis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000139:chemically induced; D010149:Postoperative Pain / Q000188:drug therapy; D011720:Pyrazoles / Q000008:administration & dosage / Q000009:adverse effects*; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib