[Eosinophil granule cationic proteins: eosinophil activation markers].
BACKGROUND
Eosinophils play a central role in the pathogenesis of allergic diseases and host protection against parasites, especially against helminths.


METHODS
Eosinophil granules contain cytotoxic proteins, including cationic proteins: major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil derived neurotoxin (EDN).


CONCLUSIONS
Eosinophil granule proteins are implicated in the occurrence of allergic diseases and Churg-Strauss syndrome. These proteins are activation markers of eosinophils and may be useful in clinical practice.
Guilpain
P
P
Faculté de Médecine, Université Paris-Descartes, UPRES-EA 1833, Paris, France.
Guillevin
L
L
Mouthon
L
L
D015415:Biomarkers; D001798:Blood Proteins / Q000502:physiology*; D015267:Churg-Strauss Syndrome / Q000097:blood; D003594:Cytoplasmic Granules / Q000502:physiology*; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000097:blood; D004676:Myelin Basic Protein / Q000502:physiology
D015415:Biomarkers; D001798:Blood Proteins; D004676:Myelin Basic Protein