title: Fatal haemoptysis in a case of lymphomatoid granulomatosis treated with rituximab.
abstract: Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin. This report describes the case of a 33-yr-old female with an aggressive form of lymphoid granulomatosis treated with an anti-CD20 antibody. Dramatic radiological improvement was seen at the fourth week. However, the patient died at home 1 month after the last rituximab administration from a massive haemoptysis.
authors.affiliation: Clinique pneumologique and Service de radiologie, CHU Rouen, Hôpital Guillaume et René Laennec, Boulevard Jacques Monod, 44093 Nantes Cedex 1, France. sandrine.jaffre@chu-nantes.fr
authors.forename: S
authors.initials: S
authors.lastname: Jaffre
authors.forename: F
authors.initials: F
authors.lastname: Jardin
authors.forename: S
authors.initials: S
authors.lastname: Dominique
authors.forename: E
authors.initials: E
authors.lastname: Duet
authors.forename: Ph
authors.initials: P
authors.lastname: Hubscher
authors.forename: A
authors.initials: A
authors.lastname: Genevois
authors.forename: F
authors.initials: F
authors.lastname: Corne
authors.forename: S
authors.initials: S
authors.lastname: Bota
authors.forename: G
authors.initials: G
authors.lastname: Nouvet
authors.forename: L
authors.initials: L
authors.lastname: Thiberville
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D017809:Fatal Outcome; D005260:Female; D006469:Hemoptysis / Q000209:etiology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008230:Lymphomatoid Granulomatosis / Q000150:complications* / Q000188:drug therapy*; D000069283:Rituximab
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab