In vitro and in vivo effects of fluoride ions on enzyme activity.
This work presents mechanisms by which interaction of fluoride ions with enzymes can take place. The effects of fluoride on enzymes participating in cellular metabolic pathways, like energy formation and carbohydrate and lipid turnover, are discussed. A list of enzymes which are inhibited or activated in vivo and in vitro by fluoride ions is provided, together with information on species and organs of origin, fluoride concentration, and extent of inhibition or activation.
Adamek
Ewa
E
Silesian Academy of Medicine, Faculty of Pharmacy, Department of General and Analytical Chemistry, Sosnowiec.
Pawłowska-Góral
Katarzyna
K
Bober
Katarzyna
K
D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology*; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control; D004789:Enzyme Activation / Q000187:drug effects; D004798:Enzymes / Q000187:drug effects*; D005459:Fluorides / Q000494:pharmacology* / Q000633:toxicity; D006019:Glycolysis / Q000187:drug effects; D006801:Humans
D004798:Enzymes; D005459:Fluorides