title: Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus.
abstract: Bitriazolyl compounds were synthesized and their activity against tobacco mosaic virus was assessed. Two of them showed promising antiviral activity and were more potent than the reference compounds. Moreover, these compounds are predicted not to be carcinogenic or mutagenic based on the prediction systems. Therefore, the bitriazolyl compounds may provide interesting new leads or scaffolds for use in further attempts to screen novel antiviral candidates.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Zhijin
authors.initials: Z
authors.lastname: Fan
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yao
authors.forename: Quan
authors.initials: Q
authors.lastname: Liao
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D014230:Triazoles