Effect of oxalate test dose size on absolute and percent oxalate absorption.
The purpose of this pilot study was to establish the dependence or independence of oxalate absorption on the quantity of the test dose of sodium oxalate over a range of test doses corresponding to physiological dietary oxalate intake values. Gastrointestinal oxalate absorption was measured with the [13C2]oxalate absorption test. Six healthy volunteers were always tested under standardized dietary conditions with 63 mg dietary oxalate and 800 mg dietary calcium per day. The volunteers were tested thrice each with sodium oxalate test doses of 25, 50, 200, and 600 mg. Additionally, 1000 mg sodium oxalate was applied once to three of these volunteers. The oxalate absorption of the six volunteers tested under the standardized conditions with 50 mg sodium [13C2]oxalate was 7.2 +/- 2.62 % (mean +/- SD), similar to the 120 volunteers tested previously: 8.0 +/- 4.4 % (mean +/- SD). The tests with sodium [13C2]oxalate doses in the range 25-1000 mg revealed similar percent oxalate absorption values. In conclusion, in healthy volunteers, the amount of oxalate absorbed in the gastrointestinal tract increased proportionally with the higher test doses of oxalate. However, percent oxalate absorption remained unchanged with test doses in the dose range of physiological dietary oxalate intakes.
von Unruh
Gerd E
GE
Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. gerd.von_unruh@ukb.uni-bonn.de
Bell
Alexandra E
AE
Hesse
Albrecht
A
D000328:Adult; D002247:Carbon Isotopes / Q000493:pharmacokinetics* / Q000652:urine; D004064:Digestive System / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000493:pharmacokinetics* / Q000652:urine; D010865:Pilot Projects; D012016:Reference Values; D014545:Urinary Calculi / Q000652:urine*
D002247:Carbon Isotopes; D010070:Oxalates