title: Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma.
abstract: OBJECTIVE
  To investigate the expression of cyclooxygenase-2 (COX-2) and epithelial growth factor receptor (EGFR) throughout the progression of Barretts esophagus (BE).
  
  
  METHODS
  COX-2 and EGFR protein expressions were detected by using immunohistochemical method. A detailed cytomorphological changes were determined. Areas of COX-2 and EGFR expression were quantified by using computer Imaging System.
  
  
  RESULTS
  The expressions of both COX-2 and EGFR increased along with the progression from BE to esophagus adenocarcinoma (EAC). A positive correlation was found between COX-2 expression and EGFR expression.
  
  
  CONCLUSIONS
  COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, thereby leading to carcinogenesis.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, J. Graham Brown Cancer Center, University of Louisville School of Medicine, 315 E. Broadway - #312, Louisville, KY 40202, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: John M
authors.initials: JM
authors.lastname: Wo
authors.forename: Mukunda B
authors.initials: MB
authors.lastname: Ray
authors.forename: Whitney
authors.initials: W
authors.lastname: Jones
authors.forename: Ruifeng R
authors.initials: RR
authors.lastname: Su
authors.forename: Susan
authors.initials: S
authors.lastname: Ellis
authors.forename: Robert C G
authors.initials: RC
authors.lastname: Martin
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D001471:Barrett Esophagus / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008297:Male; D008679:Metaplasia; D012189:Retrospective Studies
chemical_list: D051546:Cyclooxygenase 2; D066246:ErbB Receptors