In vitro effects of vitamin C and selenium on NK activity of patients with beta-thalassemia major.
In this study, the in vitro effects of vitamin C and selenium on natural killer (NK) cell activity of ss-thalassemia major patients was investigated. At first, significant decreased NK activity was found at E:T ratios of 1:1, 5:1, and 10:1 in whole thalassemia patients. Low-dose selenium treatment enhanced NK activity in patients but there was no change in the control group. High-dose selenium decreased NK activity significantly in splenectomized patients. Different doses vitamin C enhanced NK activity significantly in both splenectomized and unsplenectomized patients. According to these results, selenium dosage should be arranged carefully in thalassemia patients, whereas vitamin C can be used confidently.
Atasever
Belkis
B
Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey.
Ertan
Nesrin Zeynep
NZ
Erdem-Kuruca
Serap
S
Karakas
Zeynep
Z
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D020014:K562 Cells; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D013156:Splenectomy; D017086:beta-Thalassemia / Q000097:blood / Q000276:immunology* / Q000601:surgery
D000975:Antioxidants; D012643:Selenium; D001205:Ascorbic Acid