Determination of phenytoin sodium injection and tablets by highly accurate nephelometric titration.
A highly accurate nephelometric titration method was developed for the quantitative analysis of phenytoin sodium injection and tablets. The titration operating conditions and the validation of the method were studied. Five batches of phenytoin sodium injection and tablets were determined by the proposed method and the control experiment methods, respectively. The results of the titration are comparable to those of control experiments. The proposed method is accurate and reproducible, which is considered suitable for the quantitative analysis of a large number of samples.
Yi
Tao
T
West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China.
Zhan
Xian-Cheng
XC
Li
Cheng-Rong
CR
He
Ning
N
D000927:Anticonvulsants / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003102:Colloids; D005079:Excipients; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D010672:Phenytoin / Q000032:analysis*; D012835:Silver Nitrate / Q000737:chemistry; D013607:Tablets
D000927:Anticonvulsants; D003102:Colloids; D005079:Excipients; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013607:Tablets; D010672:Phenytoin; D012835:Silver Nitrate