Structural e-bioinformatics and drug design.
Nowadays the in silico scenario for drug design is totally dependent on structural biology and structural bioinformatics. A myriad of free bioinformatics applications and services have been posted on the web. This mini-review mentions web sites that are useful in structure-based drug design. The information is given in a logical manner, following the drug design process i.e. characterization of a protein target, modelling the protein using sequence homology, optimization of the protein structure and finally docking of small ligands into the active site.
Carpy
A J M
AJ
Laboratoire de Physico- & Toxico-Chimie des Systèmes Naturels UMR 5472 CNRS, Université de Bordeaux 1 351, Cours de la Libération, 33405 Talence cedex, France. a.carpy@lptc.u-bordeaux1.fr
Marchand-Geneste
N
N
D000595:Amino Acid Sequence; D019295:Computational Biology; D016208:Databases, Factual; D015195:Drug Design; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment
D011506:Proteins