title: Update on pathological gambling.
abstract: Pathological gambling (PG) is a significant public health concern associated with high rates of psychiatric comorbidity and mortality. Although research into the biology of PG is still in an early stage, recent advances in our understanding of motivation, reward, and addiction have provided substantial insight into the possible pathophysiology of this disorder. In addition, over the past 5 years, extraordinary progress has been made in the area of clinical research examining treatments for PG. Although PG is a disabling disorder that continues to represent a clinical challenge for the healthcare professional, our current knowledge of pharmacotherapy and psychosocial interventions offers potentially effective treatment options.
authors.affiliation: Department of Psychiatry, University of Minnesota School of Medicine, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. grant045@umn.edu.
authors.forename: Jon E
authors.initials: JE
authors.lastname: Grant
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Williams
authors.forename: Suck Won
authors.initials: SW
authors.lastname: Kim
mesh_terms: D016739:Behavior, Addictive / Q000503:physiopathology / Q000523:psychology* / Q000534:rehabilitation; D002986:Clinical Trials as Topic; D015928:Cognitive Behavioral Therapy; D003342:Corpus Striatum / Q000503:physiopathology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000503:physiopathology / Q000523:psychology* / Q000534:rehabilitation; D004298:Dopamine / Q000502:physiology; D005625:Frontal Lobe / Q000503:physiopathology; D005715:Gambling / Q000523:psychology*; D006801:Humans; D008636:Mesencephalon / Q000503:physiopathology; D009042:Motivation; D009415:Nerve Net / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012201:Reward
chemical_list: D011619:Psychotropic Drugs; D004298:Dopamine