title: Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE.
abstract: In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.
authors.affiliation: Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. phasson@nimr.mrc.ac.uk
authors.forename: P
authors.initials: P
authors.lastname: Hasson
authors.forename: Z
authors.initials: Z
authors.lastname: Paroush
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D015536:Down-Regulation; D066246:ErbB Receptors / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology; D010766:Phosphorylation; D051880:Receptors, Notch / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D066246:ErbB Receptors; D051880:Receptors, Notch; D012097:Repressor Proteins; C091023:gro protein, Drosophila