Use of growth factors to modify osteoinductivity of demineralized bone allografts: lessons for tissue engineering of bone.
Biologically active bone graft substitute materials are needed for repair and regeneration of skeletal tissues. Current approaches are focused on the use of osteoinductive agents, including bone morphogenetic proteins (BMP) in combination with biodegradable carriers. Demineralized freeze-dried bone allograft (DFDBA) can provide an osteoconductive surface and, at the same time, function as a time-release carrier for BMP. Donor variability, however, limits the predictability of DFDBA as an osteoinductive material. This article examines the use of growth factors, including platelet-rich plasma, platelet-derived growth factor, enamel matrix derivatives, and BMP-2, to enhance the osteoinductive properties of human DFDBA.
Boyan
Barbara D
BD
Georgia Institute of Technology, Atlanta, GA 30332-0363, USA. barbara.boyan@bme.gatech.edu
Ranly
Don M
DM
Schwartz
Zvi
Z
D000818:Animals; D001672:Biocompatible Materials; D001681:Biological Assay; D018775:Bone Demineralization Technique / Q000379:methods; D001846:Bone Development / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008903:Minerals / Q000378:metabolism; D016348:Osseointegration / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods
C077540:Bio-Oss; D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D008903:Minerals