A possible mechanism for phenol-induced pemphigus.
A possible mechanism for phenol-induced pemphigus lesions in genetically predisposed individuals is proposed that accounts for in vitro observations and cases of biochemical acantholysis, as well as the in vivo acantholysis in pemphigus induced by phenols. The mechanism involves the induction of interleukin-1a and tumor necrosis factor-a release by keratinocytes. These cytokines in turn have been shown to be involved in the regulation and synthesis of complement and proteases like plasminogen activator, which have been implicated in the pathogenesis of acantholysis in pemphigus vulgaris.
Brenner
Sarah
S
Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. derma@tasmc.health.gov.il
Ruocco
Vincenzo
V
Ruocco
Eleonora
E
Srebrnik
Avigdor
A
Goldberg
Ilan
I
D020022:Genetic Predisposition to Disease; D006801:Humans; D010392:Pemphigus / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D010636:Phenols / Q000009:adverse effects* / Q000494:pharmacology
D010636:Phenols