Recent translational research: stem cells as the roots of breast cancer.
Common phenotypes of cancer and stem cells suggest that breast cancers arise from stem cells. Breast epithelial cells with stem cell phenotypes have been shown to be more susceptible to immortalization and neoplastic transformation. Breast tumor stem cells with CD44+/CD24-/lowLineage- markers have been isolated. The role of these cells in tumor progression and clinical outcome is not clear. The relationship between breast stem cell and tumor stem cell may be elucidated by further studies of carcinogenesis of nonadherent mammosphere cells with stem cell features and by derivation of CD44+/CD24-/low cells from an adherent breast epithelial stem cell type.
Chang
Chia-Cheng
CC
Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, USA. cc.chang@ht.msu.edu
D001943:Breast Neoplasms / Q000503:physiopathology*; D051927:CD24 Antigen; D002448:Cell Adhesion; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D018960:Hyaluronan Receptors; D010641:Phenotype; D013234:Stem Cells
D051927:CD24 Antigen; D018960:Hyaluronan Receptors