Solid-phase staudinger ligation from a novel core-shell-type resin: a tool for facile condensation of small peptide fragments.
[reaction: see text] Solid-phase Staudinger ligation of small peptides was performed on a novel core-shell-type resin. Solid-phase Staudinger ligation was mediated by synthetic solid-supported phosphinothiol, which was readily prepared by a straightforward synthetic route. This protocol afforded final peptide products in excellent yields and purities and thus could provide the opportunity to facilitate a simple manipulation for condensation of peptide fragments. In particular, the resulting resin could be recycled in a successful manner.
Kim
Hanyoung
H
School of Chemical and Biological Engineering, Seoul National University, Kwanak-Gu, Shilim-Dong, San 56-1, Seoul 151-742, Korea.
Cho
Jin Ku
JK
Aimoto
Saburo
S
Lee
Yoon-Sik
YS
D015394:Molecular Structure; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*
D009946:Organothiophosphorus Compounds; D010446:Peptide Fragments; D010455:Peptides; D012117:Resins, Synthetic