Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis.
We report the first linezolid-resistant Staphylococcus aureus strain isolated in Brazil. The strain was isolated from a 10-year-old female patient with cystic fibrosis (CF) who received repeated and prolonged courses of low-dose linezolid. The strain belonged to the Brazilian endemic methicillin-resistant S. aureus clone, and the G2576U mutation was identified in domain V of the 23S rRNA. Detection of this mechanism of resistance in a CF patient is very worrisome, as these patients may become a reservoir for further dissemination of resistant strains. Our findings emphasise the importance of optimal dosage of linezolid to prevent the emergence of resistance.
Gales
Ana C
AC
Laboratório Alerta, Universidade Federal de São Paulo, São Paulo, Brazil. galesac@aol.com
Sader
Hélio S
HS
Andrade
Soraya S
SS
Lutz
Larissa
L
Machado
Adão
A
Barth
Afonso L
AL
D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001938:Brazil; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005260:Female; D006801:Humans; D000069349:Linezolid; D016106:Methicillin Resistance; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017354:Point Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D012338:RNA, Ribosomal, 23S; D000069349:Linezolid