title: [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2003). III. Secular changes in susceptibility].
abstract: The bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella spp. and Pseudomonas aeruginosa) isolated from 565 patients diagnosed as urinary tract infections (UTIs) in 14 institutions in Japan were collected between August 2003 and July 2004. The susceptibilities of these bacteria to various antimicrobial agents were examined. The bacteria were divided into 2 groups consisting of uncomplicated UTIs and complicated UTIs (with and without indwelling catheter) based on their isolation origins. The results were compared with those obtained between 1994 and 2002. The drug sensitivity of S. aureus in this year was similar to those in up to the previous years and S. aureus showed the best susceptibility to vancomycin. The drug sensitivity of E. faecalis in this year also was similar to those in up to the previous years. The drug sensitivity of E. coli in this year was generally good except penicillins and was similar to those in up to the previous years. Among cephems, cefozopran (CZOP) and cefpirome (CPR) showed the highest potency activity (MIC90: < or = 0.125 microg/mL). An antibacterial activity of cefotiam (CTM) was stable for 10 years and was fine (MIC0: < or = 0.5 microg/mL). The sensitivity of E. coli to carbapenems and carumonam (CRMN) also was good like to CZOP. The sensitivity of the complicated UTIs group to quinolones, however, has decreased after 2000 and it was suggested that the resistance to the drug has developed. Kiebsiella spp. showed a decrease in the susceptibility to some of cephems. The drugs indicating a big decrease in the sensitivity were cefazolin, CTM, cefaclor, and cefpodoxime. Imipenem, carbapenems, also indicated a decrease in the sensitivity. The susceptibility of the strain to the other drugs was similar to that in up to the previous years. Among them, CZOP maintained good susceptibility (MIC90: > or = 0.125 microg/mL against uncomplicated UTIs, 0.25 microg/mL against complicated UTIs) like meropenem. The drug sensitivity of P. aeruginosa was generally low and was not much different from that in up to the previous years.
authors.affiliation: Department of Urology, Sapporo Medical University School of Medicine.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kumamoto
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsukawa
authors.forename: Yasuharu
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authors.lastname: Kunishima
authors.forename: Kiyoaki
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authors.lastname: Watanabe
authors.forename: Yoshio
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authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchida
authors.forename: Seiji
authors.initials: S
authors.lastname: Matsuda
authors.forename: Takaoki
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authors.lastname: Hirose
authors.forename: Shinichi
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authors.lastname: Sato
authors.forename: Shiro
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authors.lastname: Shigeta
authors.forename: Makoto
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authors.lastname: Fujime
authors.forename: Kazuhiko
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authors.lastname: Fujita
authors.forename: Osamu
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authors.lastname: Yamaguti
authors.forename: Kei
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authors.lastname: Ishibashi
authors.forename: Jun
authors.initials: J
authors.lastname: Igari
authors.forename: Tatsuo
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authors.lastname: Suzutani
authors.forename: Toyoko
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authors.lastname: Oguri
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Imafuku
authors.forename: Keizo
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Furuya
authors.forename: Masaru
authors.initials: M
authors.lastname: Murai
authors.forename: Takashi
authors.initials: T
authors.lastname: Deguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ooe
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Mineko
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Sejij
authors.initials: S
authors.lastname: Naito
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Egashira
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Konishi
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Oka
authors.forename: Masaya
authors.initials: M
authors.lastname: Kitamura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fukuhara
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakata
authors.forename: Akira
authors.initials: A
authors.lastname: Kondo
authors.forename: Junichi
authors.initials: J
authors.lastname: Matsuda
authors.forename: Michiko
authors.initials: M
authors.lastname: Nakano
authors.forename: Sadao
authors.initials: S
authors.lastname: Kamidono
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
authors.forename: Koichi
authors.initials: K
authors.lastname: Monden
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D007709:Klebsiella / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents