Evaluation of RGS4 as a candidate gene for schizophrenia.
Several studies have suggested that the regulator of G-protein signaling 4 (RGS4) may be a positional and functional candidate gene for schizophrenia. Three single nucleotide polymorphisms (SNP) located at the promoter region (SNP4 and SNP7) and the intron 1 (SNP18) of RGS4 have been verified in different ethnic groups. Positive results have been reported in these SNPs with different numbers of SNP combinatory haplotypes. In this study, these three SNP markers were genotyped in 218 schizophrenia pedigrees of Taiwan (864 individuals) for association analysis. Among these three SNPs, neither SNP4, SNP7, SNP18 has shown significant association with schizophrenia in single locus association analysis, nor any compositions of the three SNP haplotypes has shown significantly associations with the DSM-IV diagnosed schizophrenia. Our results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated from these three SNP markers.
Liu
Yu-Li
YL
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Shen-Jang Fann
Cathy
C
Liu
Chih-Min
CM
Wu
Jer-Yuarn
JY
Hung
Shuen-Iu
SI
Chan
Hung-Yu
HY
Chen
Jiahn-Jyh
JJ
Lin
Chin-Yu
CY
Liu
Shih-Kai
SK
Hsieh
Ming H
MH
Hwang
Tzung-Jeng
TJ
Ouyang
Wen-Chen
WC
Chen
Chun-Ying
CY
Lin
Jin-Jia
JJ
Chou
Frank Huang-Chih
FH
Chueh
Ching-Mo
CM
Liu
Wei-Ming
WM
Tsuang
Ming-Min
MM
Faraone
Stephen V
SV
Tsuang
Ming T
MT
Chen
Wei J
WJ
Hwu
Hai-Gwo
HG
D000483:Alleles; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D020710:RGS Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D013624:Taiwan
D020710:RGS Proteins; C098799:RGS4 protein