Enhancement of splenic glucose metabolism during acute malarial infection: correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria.
In the current study, to elucidate the clinical features of severe malaria, we performed whole-body positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) of Plasmodium coatneyi-infected acute-phase Japanese macaques. The infected monkeys clearly exhibited increase in splenic FDG uptake indicating marked enhancement of glucose metabolism. The standardized uptake values (SUVs) of the spleen in the infected monkeys were significantly higher than those in the uninfected monkey. At autopsy, splenomegaly was clearly present in all infected monkeys, and histopathologic findings included hyperplasia of lymphoid follicles in white pulp, a large number of activated macrophage, and congestion of parasitized red blood cells (PRBCs) and malaria pigments in red pulp. We suggest that increase in splenic glucose uptake may thus be closely related to activation of splenic clearance system against blood-stage malarial parasites.
Kawai
Satoru
S
Department of Tropical Medicine and Parasitology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. skawai@dokkyomed.ac.jp
Ikeda
Eiji
E
Sugiyama
Munehiro
M
Matsumoto
Jun
J
Higuchi
Tetsuya
T
Zhang
Hong
H
Khan
Nasim
N
Tomiyoshi
Katsumi
K
Inoue
Tomio
T
Yamaguchi
Haruyasu
H
Katakura
Ken
K
Endo
Keigo
K
Matsuda
Hajime
H
Suzuki
Mamoru
M
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism*; D006651:Histocytochemistry; D008251:Macaca; D008288:Malaria / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D018512:Parasitemia / Q000000981:diagnostic imaging / Q000378:metabolism / Q000469:parasitology; D010961:Plasmodium / Q000254:growth & development*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013154:Spleen / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000469:parasitology*; D013163:Splenomegaly / Q000469:parasitology
D001786:Blood Glucose; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose