title: Spinal epidural extraskeletal Ewing sarcoma in an adolescent boy: a case report.
abstract: Extraskeletal Ewing sarcoma (EES) represents a rare soft tissue malignant neoplasm histologically similar to skeletal Ewing sarcoma. It occurs mainly in adolescents and young adults and commonly affects the paravertebral regions. The differential diagnosis includes other small, blue round cells tumors. The authors report a case of an EES involving the spinal epidural and paravertebral spaces in an adolescent boy. EES diagnosis was confirmed by features of histologic analysis and immunohistochemistry and by the presence of the t(11;22)(q24;q12) chromosomal translocation by reverse transcriptase-polymerase chain reaction.
authors.affiliation: 2nd Pediatric Department, Hematology-Oncology Unit, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. atragian@hotmail.com
authors.forename: Fani
authors.initials: F
authors.lastname: Athanassiadou
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tragiannidis
authors.forename: Maria
authors.initials: M
authors.lastname: Kourti
authors.forename: Theodotis
authors.initials: T
authors.lastname: Papageorgiou
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Kotoula
authors.forename: Vassilios
authors.initials: V
authors.lastname: Kontopoulos
authors.forename: John
authors.initials: J
authors.lastname: Christoforidis
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001416:Back Pain / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics / Q000648:ultrastructure; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics / Q000648:ultrastructure; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004273:DNA, Neoplasm / Q000235:genetics; D004317:Doxorubicin / Q000008:administration & dosage; D004824:Epidural Space; D005047:Etoposide / Q000008:administration & dosage; D050815:Fractures, Compression / Q000209:etiology; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007796:Laminectomy; D008279:Magnetic Resonance Imaging; D008297:Male; D015080:Mesna / Q000008:administration & dosage; D009363:Neoplasm Proteins / Q000032:analysis; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D018714:Radiotherapy, Adjuvant; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012512:Sarcoma, Ewing / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000601:surgery; D016103:Spinal Fractures / Q000209:etiology; D013904:Thoracic Vertebrae / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000032:analysis / Q000235:genetics; D014178:Translocation, Genetic; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C106031:EWS-FLI fusion protein; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D014157:Transcription Factors; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D015080:Mesna; D007069:Ifosfamide