title: Penifulvin A: a sesquiterpenoid-derived metabolite containing a novel dioxa[5,5,5,6]fenestrane ring system from a fungicolous isolate of Penicillium griseofulvum.
abstract: [structure: see text] Penifulvin A (1), a new fungal metabolite with a previously undescribed ring system, has been isolated from cultures of an isolate of Penicillium griseofulvum (NRRL 35584) obtained from a white mycelial growth on a dead hardwood branch collected in a Hawaiian forest. The structure was assigned by analysis of NMR data and confirmed by single-crystal X-ray diffraction analysis. Penifulvin A (1) shows significant activity in dietary assays against the fall armyworm Spodoptera frugiperda.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Shim
authors.forename: Dale C
authors.initials: DC
authors.lastname: Swenson
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Dowd
authors.forename: Donald T
authors.initials: DT
authors.lastname: Wicklow
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006254:Hawaii; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018411:Spodoptera / Q000187:drug effects*
chemical_list: D012717:Sesquiterpenes; C515096:penifulvin A