title: [Cryptococcal meningo-encephalitis in an apparently immunocompetent patient].
abstract: BACKGROUND
  Cryptococcal meningo-encephalitis is a rare disease occurring more frequently in immunocompromised hosts.
  
  
  METHODS
  We report the case of an apparently immunocompetent patient who developed a recurrent neurological deficit with lymphocytic meningitis. The time from the first symptoms to diagnosis was 8 months. We noted mild CD4+ lymphocytopenia (500 cells/mm3) without HIV infection. CD4+ lymphocytes were not reactive for a panel of antigens.
  
  
  CONCLUSIONS
  This case illustrates the usefulness of cerebrospinal fluid Cryptococcus Neoformans antigen test in patients with an unexplained neurological syndrome with a lymphocytic meningitis together with quantification of circulating lymphocytes clusters and analyse of their function in opportunistic infections.
authors.affiliation: Service de Neurologie, CH de Versailles, Hôpital A. Mignot, Le Chesnay.
authors.forename: K
authors.initials: K
authors.lastname: Bretaudeau
authors.forename: O
authors.initials: O
authors.lastname: Eloy
authors.forename: A
authors.initials: A
authors.lastname: Richer
authors.forename: F
authors.initials: F
authors.lastname: Bruneel
authors.forename: D
authors.initials: D
authors.lastname: Scott-Algara
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
authors.forename: F
authors.initials: F
authors.lastname: Pico
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000097:blood; D001921:Brain / Q000473:pathology; D018791:CD4 Lymphocyte Count; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D004359:Drug Therapy, Combination; D004660:Encephalitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D008279:Magnetic Resonance Imaging; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D000666:Amphotericin B; D005437:Flucytosine