title: A new cytotoxic lanostane triterpenoid from the basidiomycete Hebeloma versipelle.
abstract: A new cytotoxic lanostane triterpenoid, 24(E)-3beta-hydroxylanosta-8,24-dien-26-al-21-oic acid (1), was isolated from the fruiting bodies of the mushroom Hebeloma versipelle. The structure was elucidated on the basis of spectroscopic studies including 2D NMR experiments. Compound 1 moderately inhibited the growth of several tumor cell lines (IC50 10-25.0 microg/ml).
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Shao
authors.forename: Chen
authors.initials: C
authors.lastname: Qing
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Du-Qiang
authors.initials: DQ
authors.lastname: Luo
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D001487:Basidiomycota / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: C508793:3-hydroxylanosta-8,24-dien-26-al-21-oic acid; D000903:Antibiotics, Antineoplastic; D013778:Tetrazolium Salts; D013844:Thiazoles; D007810:Lanosterol; C022616:thiazolyl blue