Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury.
Traumatic brain injury (TBI) frequently results in cerebrovascular lesions that may increase secondary damage and cause neuropsychological impairment. Previous studies suggest an association among the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE), cardiovascular disease, and cognitive performance. Clinical and experimental studies have demonstrated the beneficial effects of ACE inhibitor treatment on vascular injury, hypertension, brain ischemia, and cognitive functioning. In a sample of 73 moderate and severe TBI patients, the authors assessed whether cognitive sequelae differed in relation to the ACE I/D polymorphism. D allele carrier patients performed worse than those with I/I polymorphism on tests involving attention and processing speed. Findings suggest that the physiopathological changes associated with TBI may have greater consequences in ACE D allele carriers.
Ariza
Mar
M
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS C/Casanova, 143 08036 Barcelona. marizago7@docd4.ub.edu
Matarin
Maria Del
MD
Junqué
Carme
C
Mataró
María
M
Clemente
Immaculada
I
Moral
Pedro
P
Antonia Poca
María
M
Garnacho
Angel
A
Sahuquillo
Juan
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D020087:Alu Elements / Q000235:genetics*; D020208:Brain Injury, Chronic / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002886:Chromosomes, Human, Pair 17; D004251:DNA Transposable Elements / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D015600:Glasgow Coma Scale; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011597:Psychomotor Performance
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A