title: [Genetic diversity of hepatitis A virus in Siberia].
abstract: The nucleotide sequences of a region of VP1/2A genes of a large group of hepatitis A virus (HAV) isolates circulating in Siberia (the Altai Territory, the Irkutsk and Novosibirsk Regions) were determined. Comparison of these sequences with those of prototype HAV of genotypes IA, IB, and IIA revealed their high similarity to prototype genotype IA strains. The above domains were shown to contain the types of viruses, which were close to both the European subtypes of HAV genotypes IA (78.3%) and the Far Eastern subtypes of this genotype (21.7%). The similar comparison of the derived amino acid sequences suggests that VP1 and 2A contains the amino acid substitutions that are typical of this geographical region.
authors.forename: V A
authors.initials: VA
authors.lastname: Ternovoĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Chausov
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Bondarenko
authors.forename: G V
authors.initials: GV
authors.lastname: Kochneva
authors.forename: G F
authors.initials: GF
authors.lastname: Sivolobova
authors.forename: A A
authors.initials: AA
authors.lastname: Grazhdantseva
authors.forename: S V
authors.initials: SV
authors.lastname: Netesov
mesh_terms: D019943:Amino Acid Substitution; D003546:Cysteine Endopeptidases / Q000235:genetics; D014644:Genetic Variation; D006506:Hepatitis A / Q000821:virology; D030041:Hepatitis A virus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D012800:Siberia; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: C096539:VP1 protein, hepatitis A virus; D014764:Viral Proteins; D015678:Viral Structural Proteins; D003546:Cysteine Endopeptidases; C057400:picornain 2A, Picornavirus