PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.
Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
Finck
Brian N
BN
Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Kelly
Daniel P
DP
D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism*; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D006331:Heart Diseases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1