title: Eimeria tenella: B-cell epitope mapping following primary and secondary infections.
abstract: Immunisation against coccidiosis has become more reliable and effective with improved administration techniques for new vaccines. On the other hand, an ideal coccidial vaccine should contain both B- and T-cell immunogenic epitopes. Fine specificity of B-cell epitopes recognised by antibodies prepared following primary and secondary infections with Eimeria tenella were studied using "PepScan" techniques. Mapping of B-cell epitopes within an antigenic sequence from E. tenella showed that four distinct types of epitopes were recognised by the host immune system during the primary and secondary infections with the parasite. These observations demonstrated that new epitopes are also involved in induction of antibody responses following the secondary infection.
authors.affiliation: Poultry Diseases Division, Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, P.O. Box 1177, Urmia, Iran. a.talebi@mail.urmia.ac.ir
authors.forename: Alireza
authors.initials: A
authors.lastname: Talebi
authors.forename: Grace
authors.initials: G
authors.lastname: Mulcahy
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis / Q000097:blood; D000918:Antibody Specificity; D000953:Antigens, Protozoan / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000276:immunology / Q000662:veterinary*; D016786:Eimeria tenella / Q000276:immunology*; D018604:Epitope Mapping / Q000662:veterinary; D018985:Epitopes, B-Lymphocyte / Q000276:immunology*; D033661:Oocysts / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology* / Q000469:parasitology; D012008:Recurrence; D013047:Specific Pathogen-Free Organisms
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D018985:Epitopes, B-Lymphocyte