title: Value of the American College of Cardiology/American Heart Association angiographic classification of coronary lesion morphology in patients with in-stent restenosis. Insights from the Restenosis Intra-stent Balloon angioplasty versus elective Stenting (RIBS) randomized trial.
abstract: BACKGROUND
  The implications of the American College of Cardiology/American Heart Association (ACC/AHA) lesion classification in patients with in-stent restenosis (ISR) are unknown.
  
  
  METHODS
  Four hundred fifty patients included in the RIBS randomized study were analyzed. A centralized core laboratory assessed ISR classifications including ACC/AHA, the classification of Mehran et al (Circulation 1999;100:1872-8), diffuse/focal, and a new quantitative ISR index (lesion length/stent length). Logistic regression models were constructed for prespecified outcome measures including (1) unsatisfactory acute results and (2) recurrent restenosis rate.
  
  
  RESULTS
  Complex (B2/C) lesions (78%) more frequently obtained unsatisfactory acute results (20% vs 8%, P = .007), smaller minimal lumen diameter after the procedure (2.45 +/- 0.5 vs 2.73 +/- 0.5 mm, P = .001) and at follow-up (1.48 +/- 0.8 vs 1.94 +/- 0.8 mm, P = .0001), and had a higher restenosis rate (43 vs 24%, P = .001) than simple (A/B1) lesions. On logistic regression analysis, all classification schemes were useful to predict unsatisfactory initial results (area under the curve: 0.63, 0.61, 0.59, and 0.62) and recurrent restenosis (area under the curve: 0.60, 0.64, 0.61, and 0.63). The predictive ability of these schemes persisted despite adjustment for potential confounders. Although the ACC/AHA classification was a better predictor of acute results, the classification of Mehran was superior to predict restenosis.
  
  
  CONCLUSIONS
  The ACC/AHA classification provides a useful tool to determine acute procedural results and the long-term angiographic outcome of patients with ISR.
authors.affiliation: University Hospital Clinico San Carlos, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Alfonso
authors.forename: Angel
authors.initials: A
authors.lastname: Cequier
authors.forename: Juan
authors.initials: J
authors.lastname: Angel
authors.forename: Vicens
authors.initials: V
authors.lastname: Martí
authors.forename: Javier
authors.initials: J
authors.lastname: Zueco
authors.forename: Armando
authors.initials: A
authors.lastname: Bethencourt
authors.forename: Ramón
authors.initials: R
authors.lastname: Mantilla
authors.forename: José R
authors.initials: JR
authors.lastname: López-Minguez
authors.forename: Manuel
authors.initials: M
authors.lastname: Gómez-Recio
authors.forename: César
authors.initials: C
authors.lastname: Morís
authors.forename: María J
authors.initials: MJ
authors.lastname: Perez-Vizcayno
authors.forename: Cristina
authors.initials: C
authors.lastname: Fernández
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
authors.forename: Ricardo
authors.initials: R
authors.lastname: Seabra-Gomes
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000145:classification* / Q000000981:diagnostic imaging* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D015607:Stents