title: Toward synthesis of the regular sequence of heparin: synthesis of two tetrasaccharide precursors.
abstract: Two fully protected tetrasaccharides, which represent precursors for the synthesis of the regular sequence of heparin, were synthesized via coupling of a pair of disaccharide trichloroacetimidates with a thioglycoside and a glucosamine derivative, respectively, in a sequential manner.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.forename: Jianfang
authors.initials: J
authors.lastname: Chen
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000081:Acetamides; D002240:Carbohydrate Sequence; D062845:Chloroacetates; D006493:Heparin / Q000138:chemical synthesis*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis*; D013865:Thioglycosides / Q000737:chemistry; D014238:Trichloroacetic Acid / Q000737:chemistry
chemical_list: D000081:Acetamides; D062845:Chloroacetates; D009844:Oligosaccharides; D013865:Thioglycosides; D014238:Trichloroacetic Acid; D006493:Heparin; C009528:trichloroacetamide