Effect of topical alendronate treatment on fixation of implants inserted with bone compaction.
Bone compaction has been shown to enhance the critical initial implant stability that is important for secure long-term fixation. We investigated whether topical bisphosphonate treatment improves fixation of implants inserted with bone compaction. Porous-coated titanium implants were inserted with bone compaction into the knees of eight dogs. In the right knee, topical bisphosphonate treatment was applied before bone compaction. Saline was used as a control in the left knee. The knees were observed for 4 weeks. We found an increase in total bone-to-implant contact and total bone density around the implants in the bisphosphonate-treated group. These were results of increased nonvital bone-to-implant contact and increased nonvital periimplant bone density. No change in biomechanical fixation was found. Studies with a longer followup are needed to investigate whether the preservative effect of alendronate on nonvital bone might enhance implant fixation by osteoconduction.
Jakobsen
Thomas
T
Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark. tvj@studmed.au.dk
Kold
Søren
S
Bechtold
Joan E
JE
Elmengaard
Brian
B
Søballe
Kjeld
K
D000287:Administration, Topical; D019386:Alendronate / Q000627:therapeutic use*; D000818:Animals; D019643:Arthroplasty, Replacement / Q000379:methods*; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004285:Dogs; D019544:Equipment Failure Analysis; D005260:Female; D005269:Femur / Q000601:surgery*; D033081:Shear Strength; D016474:Weight-Bearing
D050071:Bone Density Conservation Agents; D019386:Alendronate