title: Synthesis and peptidyl-prolyl isomerase inhibitory activity of quinoxalines as ligands of cyclophilin A.
abstract: In search of small molecule compounds as the ligands of cyclophilin A, a series of quinoxalines were prepared, and their K(d) values of cyclophilin A and IC50 values for peptidyl-prolyl isomerase activity of cyclophilin A were tested. The results suggest that some quinoxalines are promising ligands of cyclophilin A.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Xuejun
authors.initials: X
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Shen
authors.forename: Xuchang
authors.initials: X
authors.lastname: He
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Donglu
authors.initials: D
authors.lastname: Bai
mesh_terms: D021984:Cyclophilin A / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D019696:Peptidylprolyl Isomerase / Q000037:antagonists & inhibitors*; D011810:Quinoxalines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D020349:Surface Plasmon Resonance
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D011810:Quinoxalines; D021984:Cyclophilin A; D019696:Peptidylprolyl Isomerase