title: [Expressions of Her-2, EGFR, PS-2 and ER in breast cancer and their clinical implications].
abstract: OBJECTIVE
  To detect the expressions of human epidermal growth factor receptor 2 (Her-2), epidermal growth factor receptor (EGFR), presenilin 2 (PS-2) and estrogen receptor (ER) in breast cancer and discuss their clinical implications.
  
  
  METHODS
  The expressions of Her-2, EGFR, PS-2 and ER were measured immunohistochemically in 108 patients with breast cancer.
  
  
  RESULTS
  The positive expression rates of Her-2, EGFR, PS-2 and ER were 37.0%, 40.7%, 57.4% and 53.7% respectively in the breast cancer patients. The expression of Her-2 was not correlated with EGFR, but inversely correlated with PS-2 and ER. The expressions of Her-2 and EGFR, PS-2, ER were correlated with the histological grades (P<0.05), and Her-2, EGFR and ER expressions with lymph node metastasis (P<0.05). The expressions of Her-2, EGFR, PS-2 and ER did not correlate to the pathological types, patient's age and tumor size (P>0.05).
  
  
  CONCLUSIONS
  Expressions of Her-2 and EGFR often suggests an unfavorable prognosis while expressions of PS-2 and ER suggest a more favorable one. Expressions of Her-2, EGFR, PS-2 and ER are useful prognostic factors in breast cancer patients.
authors.affiliation: Department of Oncology, 91 Hospital of PLA, Jiaozuo 454003, China. tracyxulei@126.com
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Zhong-hong
authors.initials: ZH
authors.lastname: Bai
authors.forename: Ruan-cheng
authors.initials: RC
authors.lastname: Xu
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.forename: Fang-ju
authors.initials: FJ
authors.lastname: Wang
authors.forename: Rong-cheng
authors.initials: RC
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D053766:Presenilin-2 / Q000096:biosynthesis*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D011960:Receptors, Estrogen / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D053766:Presenilin-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; C508053:ERBB2 protein, human