An improved asymmetric reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol.
[reaction: see text] (-)-N,N-Dimethylaminoisoborneol ((-)-DAIB) was found to be an excellent ligand for the enantioselective addition of Reformatsky reagents to aromatic and aliphatic aldehydes. Enantioselectivities up to 93% ee were obtained with sulfur-containing aldehydes.
Kloetzing
Ralf J
RJ
Department of Chemistry and Biochemistry, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81377 Munich, Germany.
Thaler
Tobias
T
Knochel
Paul
P
D000447:Aldehydes / Q000737:chemistry; D001892:Camphanes / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D001892:Camphanes; D008024:Ligands; C515086:N,N-dimethylaminoisoborneol