Oscillations and slow patterning in the antennal lobe.
Odor presentation generates both fast oscillations and slow patterning in the spiking activity of the projection neurons (PNs) in the antennal lobe (AL) of locusts, moths and bees. Experimental results indicate that the oscillations are the result of the interaction between the PNs and the inhibitory local neurons (LNs) in the AL; e.g., blocking inhibition by application of GABA-receptor antagonists abolishes these oscillations. The slow patterning, on the other hand, was shown to be somewhat resistant to such blockage. In a H-H model, we reproduce both the oscillations and the slow patterning. As previously suggested, the oscillations are the result of the interaction between the PNs and LNs. We suggest that calcium and calcium-dependent potassium channels (found in PNs of bees and moths) are sufficient to account for the slow patterning resistant to the application of GABA-receptor antagonists. The intrinsic bursting property of the PNs, resulting from these additional modeled currents, give rise to another network feature that was seen experimentally in locusts: A relatively small increase in the number of additional generated PN action potentials when LN input is blocked. Consequently, the major effect of network inhibition is to redistribute the action potentials of the PNs from bursting to one action potential per cycle of the oscillations.
Sivan
Ehud
E
Center for Biodynamic, Boston University, 111 Cummington Street, MA, 02215, USA. ehud@bu.edu
Kopell
Nancy
N
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003198:Computer Simulation; D018756:GABA Antagonists / Q000494:pharmacology; D007313:Insecta; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009812:Odorants; D010507:Periodicity; D024681:Potassium Channels, Calcium-Activated / Q000502:physiology; D011336:Probability; D012679:Sense Organs / Q000166:cytology*
D018756:GABA Antagonists; D024681:Potassium Channels, Calcium-Activated; D002118:Calcium