title: Cystectomy delay more than 3 months from initial bladder cancer diagnosis results in decreased disease specific and overall survival.
abstract: OBJECTIVE
  Some groups hypothesize that a delay in cystectomy may result in higher pathological stage and possibly alter survival in patients with bladder cancer. The timing of this delay has been somewhat arbitrary. We evaluated the timing from T2 bladder cancer diagnosis to cystectomy, its impact on survival and potential causes of delay.
  
  
  METHODS
  A contemporary cohort of 214 consecutive patients presented with clinical T2 bladder cancer and underwent radical cystectomy as primary therapy. Clinicopathological parameters were maintained in an institutional database. A review of time to cystectomy, pathological stage, disease specific survival and OS was performed. Variables were tested in univariate and multivariate analyses. The log rank test was used for exploratory analyses to determine meaningful delay cutoff points.
  
  
  RESULTS
  Mean followup and time to cystectomy in the entire cohort was 40 months and 60 days, respectively. A significant disease specific survival and OS advantage was observed in patients undergoing cystectomy by 93 days or less (3.1 months) compared to greater than 93 days (p = 0.05 and 0.02, respectively). Pathological staging was similar between the groups (p = 0.15). A multivariate benefit in OS was observed in patients treated with timely cystectomy. The most common factor contributing to cystectomy delay was scheduling delay, as seen in 46% of cases.
  
  
  CONCLUSIONS
  A cystectomy delay of 3.1 months undermines patient survival, likely through the development of micrometastases, since local stage progression is not apparent at this point. Most delays are avoidable and should be minimized. Despite the need for second opinions and the impact of busy surgical schedules clinicians must strive to schedule patients efficiently and complete surgical treatment within this time frame.
authors.affiliation: Michigan Urology Center, University of Michigan, Ann Arbor, Michigan, USA. ctlee@umich.edu
authors.forename: Cheryl T
authors.initials: CT
authors.lastname: Lee
authors.forename: Rabii
authors.initials: R
authors.lastname: Madii
authors.forename: Stephanie
authors.initials: S
authors.lastname: Daignault
authors.forename: Rodney L
authors.initials: RL
authors.lastname: Dunn
authors.forename: Yingxi
authors.initials: Y
authors.lastname: Zhang
authors.forename: James E
authors.initials: JE
authors.lastname: Montie
authors.forename: David P
authors.initials: DP
authors.lastname: Wood
mesh_terms: D000368:Aged; D015653:Cystectomy; D005260:Female; D006801:Humans; D008297:Male; D015996:Survival Rate; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*