title: Assessment of a rapid urinary antigen detection by an immunochromatographic test for diagnosis of pneumococcal infection in children.
abstract: The aim of the study was to evaluate the Binax Now rapid immunochromatographic test (ICT) for the detection of Streptococcus pneumoniae urinary antigen in children suffering from potentially pneumococcal infections. A total of 287 patients, with a median age of 34.9 months and divided into 3 groups, were studied; the first group of patients with a suspected pneumococcal infection (n = 112), the second group with infectious symptoms nonsuggestive of a pneumococcal infection (n = 54), and the third group was composed of asymptomatic children (n = 121). In group 1, sensitivity of ICT was 100% and specificity was 55.9% (95% confidence interval, 44.1- 67.7). Forty-six (85.1%) patients from the second group were true negatives. Twenty-five (20.7%) patients from the third study group were nasopharyngeal pneumococcal carriers, and the ICT was positive in 13 carriers (10.7%). The high sensitivity level of ICT in our study indicates that a negative test could rule out a pneumococcal infection, contrasted with a poor specificity.
authors.affiliation: Saint Antoine Pediatric Clinic, Saint Vincent de Paul Hospital, Faculty of Medicine, Catholic University of Lille, 590191 Lille, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Charkaluk
authors.forename: Nicolas
authors.initials: N
authors.lastname: Kalach
authors.forename: Hector
authors.initials: H
authors.lastname: Mvogo
authors.forename: Eric
authors.initials: E
authors.lastname: Dehecq
authors.forename: Hélène
authors.initials: H
authors.lastname: Magentie
authors.forename: Josette
authors.initials: J
authors.lastname: Raymond
authors.forename: Dominique
authors.initials: D
authors.lastname: Gendrel
authors.forename: Odile
authors.initials: O
authors.lastname: Kremp
authors.forename: Anne
authors.initials: A
authors.lastname: Decoster
mesh_terms: D000942:Antigens, Bacterial / Q000652:urine*; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007120:Immunochemistry / Q000379:methods; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000382:microbiology; D010033:Otitis Media / Q000382:microbiology; D011008:Pneumococcal Infections / Q000175:diagnosis* / Q000652:urine*; D018410:Pneumonia, Bacterial / Q000382:microbiology; D012680:Sensitivity and Specificity
chemical_list: D000942:Antigens, Bacterial