title: Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity.
abstract: This review summarizes the association of increased susceptibility to mycobacterial disease in patients with genetic defects affecting innate and adaptive immunity. The optimum function of CD4 T-cell and macrophage function is critically important for immunity against mycobacteria. Antibody, complement and neutrophil function is not required for effective anti-mycobacterial immunity.
authors.affiliation: Department of Clinical Biochemistry and Immunology, Box 109, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.
authors.forename: Rainer
authors.initials: R
authors.lastname: Doffinger
authors.forename: Smita Y
authors.initials: SY
authors.lastname: Patel
authors.forename: Dinakantha S
authors.initials: DS
authors.lastname: Kumararatne
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007371:Interferon-gamma / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009161:Mycobacterium; D009164:Mycobacterium Infections / Q000209:etiology / Q000235:genetics* / Q000276:immunology
chemical_list: D007371:Interferon-gamma