Colon cancer cells: pro-invasive signalling.
Colon cancer results from erroneous renewal of the enteric epithelium. Mutations in stem cells, or their proliferative progenitors, cause accumulation of cells that invade into the stroma and continue to divide rather than migrating on top of the basement membrane prior to entering into apoptosis. Many of these changes in invasive activity appear to be related to the invasion-suppressor role of E-cadherin. We have also investigated Listeria monocytogenes and other enteric bacteria, since these bacteria stimulate invasion through the production of a beta-casein-derived 13-amino acid peptide which is produced by enzymes present in the colon cancer ecosystem. The pro-invasive 13-amino acid peptide signals via small guanosine triphosphatases, which modulate the actin cytoskeleton, and via phosphorylation of the delta opioid receptor. The pro-invasive activity of this peptide is neutralized by the delta opioid receptor antagonist, naloxone. Since the delta opioid receptor belongs to the family of G protein-coupled receptors, implicated in colon cancer cell invasion signalling pathways, it is tempting to speculate that opioids could play a role in mediating this trait of malignant tumours.
Debruyne
Delphine
D
Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 1P7, B-9000 Ghent, Belgium.
Oliveira
Maria José
MJ
Bracke
Marc
M
Mareel
Marc
M
Leroy
Ancy
A
D017209:Apoptosis / Q000502:physiology; D003110:Colonic Neoplasms / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008089:Listeria monocytogenes / Q000502:physiology; D008088:Listeriosis / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D008954:Models, Biological; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology; D011957:Receptors, Opioid / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D011957:Receptors, Opioid