title: Photoallergic contact dermatitis from ketoprofen in southern Sweden.
abstract: The non-steroidal anti-inflammatory drug ketoprofen is widely used for topical treatment. In Sweden, ketoprofen has been available for topical application since 1995. Photoallergic contact dermatitis from ketoprofen-containing topical preparations usually includes severe eczematous reactions. Ketoprofen is derived from propionic acid, and it is also a substituted benzophenone and therefore structurally similar to fenofibrate and sunscreen agents based on benzophenones. During the last 2 years, 35 patients have been refereed to our department with suspected photoallergic or allergic reactions after having used ketoprofen-containing gels. Photopatch testing with the photopatch standard series, the ketoprofen-containing gels and their ingredients, fenofibrate, benzophenone-3, benzophenone-10 and benzophenone-4, was performed. Photoallergic reactions to ketoprofen were noted in 35 patients and a simultaneous contact allergy to ketoprofen in 2 patients. Simultaneous photoallergy to fentichlor, tetrachlorosalicylanilide and fenofibrate was registered in 74%, 40% and 73% of the patients, respectively.
authors.affiliation: Department of Occupational and Environmental Dermatology, Malmö University Hospital, Lund University, Malmö, Sweden. monica.hindsen@derm.mas.lu.se
authors.forename: Monika
authors.initials: M
authors.lastname: Hindsén
authors.forename: Erik
authors.initials: E
authors.lastname: Zimerson
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000737:chemistry; D017454:Dermatitis, Photoallergic / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005260:Female; D005782:Gels / Q000009:adverse effects / Q000737:chemistry; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D013548:Sweden / Q000453:epidemiology
chemical_list: D000485:Allergens; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D007660:Ketoprofen