title: Marked decrease of plasma VEGF after implantation of autologous bone marrow mononuclear cells in a patient with critical limb ischemia--a case report.
abstract: The authors performed autologous bone marrow mononuclear cells implantation (BMI) in a 79-year-old man with critical limb ischemia. After BMI, the resting pain of the ischemic leg improved gradually. They measured the plasma concentrations of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and serum hepatocyte growth factor (HGF) in the blood from bilateral femoral veins. Before BMI, the plasma VEGF and bFGF concentrations were much greater in the ischemic leg than in the other lower limb, but decreased to the same concentrations as those in the contralateral lower extremity after BMI. The large concentrations of the angiogenic factors VEGF and bFGF in plasma indicate the severity and extent of the leg ischemia. BMI resulted in lower levels of VEGF and bFGF, and this fall is the hallmark of the effectiveness of BMI in the treatment of peripheral artery disease.
authors.affiliation: Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan. takuya-o@med.niigata-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Ozawa
authors.forename: Kiminori
authors.initials: K
authors.lastname: Kato
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sanada
authors.forename: Yashiro
authors.initials: Y
authors.lastname: Makiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Saigawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Souda
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Furukawa
authors.forename: Ken
authors.initials: K
authors.lastname: Toba
authors.forename: Makoto
authors.initials: M
authors.lastname: Kodama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Osamu
authors.initials: O
authors.lastname: Namura
authors.forename: Junichi
authors.initials: J
authors.lastname: Hayashi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay; D005263:Femoral Artery / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008297:Male; D009000:Monocytes / Q000637:transplantation*; D011859:Radiography; D014182:Transplantation, Autologous; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A