A two-stage linkage analysis of Chinese schizophrenia pedigrees in 10 target chromosomes.
We performed a two-stage linkage scan involving 25 Chinese schizophrenia families, focusing on 10 target chromosomes which have already been the subject of considerable research. We initially genotyped 237 individuals with 186 markers, five candidate regions were then chosen for fine mapping and 49 additional markers were genotyped. In region 1q21-23, a maximum multipoint HLOD (HLOD=2.38) was observed between D1S484 and D1S2705, under the dominant model. In region 5q35, dominant HOLD of 2.36, 2.04, and 2.31 were found at marker D5S2030, D5S408, and D5S2006, respectively. Consistent multipoint results also supported linkage to this region under the same dominant model, with a highest HOLD of 2.47. Furthermore, single-point HLODs (HLOD=1.95 at D22S274, and HLOD=1.91 at D22S1157) were found in region 22q13, under the dominant model. Evidence from these three regions satisfied the criteria for suggestive linkage and should help in identifying schizophrenia susceptibility genes.
Zheng
Yonglan
Y
Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Wang
Xiaoyan
X
Gu
Niufan
N
Feng
Guoyin
G
Zou
Fanggeng
F
Qin
Wei
W
Zhang
Jing
J
Lin
Wei
W
Tao
Ran
R
Qian
Xueqing
X
He
Lin
L
D002681:China / Q000453:epidemiology; D002869:Chromosome Aberrations; D002874:Chromosome Mapping / Q000379:methods*; D002877:Chromosomes, Human / Q000235:genetics*; D005260:Female; D018390:Gene Targeting; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*
D005819:Genetic Markers