title: Periodontal debridement with povidone-iodine in periodontal treatment: short-term clinical and biochemical observations.
abstract: BACKGROUND
  The aim of the present study was to evaluate the clinical effects of one-stage periodontal debridement with an ultrasonic instrument, associated with 0.5% povidone (pvp)-iodine irrigation in patients with chronic periodontitis.
  
  
  METHODS
  Forty-five patients were randomly assigned into three groups: the control group (CG) received quadrant root planing at 1-week intervals over four consecutive sessions; the periodontal debridement plus pvp-iodine group (PD-PIG) received a 45-minute full-mouth debridement with an ultrasonic instrument, associated with 0.5% pvp-iodine irrigation; and the periodontal debridement group (PDG) received a 45-minute full-mouth periodontal debridement with an ultrasonic instrument, associated with NaCl irrigation.
  
  
  RESULTS
  At the 3-month evaluation, the mean probing depth (PD) reduction in CG was 2.51+/-0.52 mm, 2.53+/-0.50 mm in PD-PIG, and 2.58+/-0.60 mm in PDG (P<0.05). The clinical attachment level (CAL) analysis showed a statistically significant gain in all groups compared to baseline (1.87+/-0.56 mm [CG], 1.94+/-0.70 mm [PD-PIG], and 1.99+/-0.92 mm [PDG]). Intergroup analysis of PD and CAL at 1 and 3 months showed no differences (P>0.05). The N-benzoyl-L-arginine-p-nitroanilide (BAPNA) test showed a significant reduction in trypsin activity only during the first month (P<0.05); at 3 months there were no differences compared to baseline (P=0.80).
  
  
  CONCLUSIONS
  This study provides no evidence that pvp-iodine is effective as an adjunct for one-stage periodontal debridement.
authors.affiliation: Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Guilherme M
authors.initials: GM
authors.lastname: Zanatta
authors.forename: Sandro
authors.initials: S
authors.lastname: Bittencourt
authors.forename: Francisco H
authors.initials: FH
authors.lastname: Nociti
authors.forename: Enilson A
authors.initials: EA
authors.lastname: Sallum
authors.forename: Antonio W
authors.initials: AW
authors.lastname: Sallum
authors.forename: Marcio Z
authors.initials: MZ
authors.lastname: Casati
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001586:Benzoylarginine Nitroanilide; D002908:Chronic Disease; D003773:Dental Plaque / Q000201:enzymology; D012534:Dental Scaling / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy* / Q000628:therapy; D011206:Povidone-Iodine / Q000627:therapeutic use*; D011446:Prospective Studies; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; D001586:Benzoylarginine Nitroanilide