title: Placental Doppler velocimetry in gestational diabetes mellitus.
abstract: OBJECTIVE
  To evaluate if maternal glucose level and growth of the fetus were related to placental vascular impedance in pregnancy complicated by gestational diabetes mellitus.
  
  
  METHODS
  A retrospective study of 146 gestational diabetic women of which 117 needed insulin therapy. Glycosylated hemoglobin (HbA1c) was evaluated as well as umbilical and uterine artery Doppler velocimetry. The results were related to adverse outcome of pregnancy including newborn birthweight.
  
  
  RESULTS
  Abnormal umbilical artery blood flow velocity was seen in 5% of the cases and abnormal uterine artery flow in 16%. Uterine and umbilical artery vascular impedance was significantly lower in macrosomic newborns. There was a poor correlation between HbA1c, vascular impedance and birthweight. There were 11 cases that developed preeclampsia, all having abnormal uterine artery Doppler and two abnormal umbilical artery Doppler.
  
  
  CONCLUSIONS
  Uterine and umbilical artery vascular impedance in pregnancies complicated by gestational diabetes is related to birthweight and placental weight, but not to maternal HbA1c levels. Placental Doppler ultrasound does not seem to be of clinical value for fetal surveillance in these pregnancies unless the pregnancy is complicated by preeclampsia and/or intrauterine fetal growth restriction.
authors.affiliation: Karol Marcinkowski University of Medical Sciences, Poznan, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Pietryga
authors.forename: Jacek
authors.initials: J
authors.lastname: Brazert
authors.forename: Ewa
authors.initials: E
authors.lastname: Wender-Ozegowska
authors.forename: Mariusz
authors.initials: M
authors.lastname: Dubiel
authors.forename: Saemundur
authors.initials: S
authors.lastname: Gudmundsson
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D010920:Placenta / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011247:Pregnancy; D012189:Retrospective Studies; D018617:Ultrasonography, Doppler, Pulsed
chemical_list: D001786:Blood Glucose