Multiple fiber laser-induced thermotherapy for ablation of large intrahepatic tumors.
OBJECTIVE
The aim of this study was to test three techniques used simultaneously to increase lesion size.


BACKGROUND
Laser-induced thermotherapy (LITT) is a method of local tumor ablation, which may prolong survival in patients with unresectable liver metastases. The main limitation has been the production of lesions with sufficient tumor-free margin.


METHODS
LITT treatment was performed with water-cooled, multiple fiber application and hepatic blood flow occlusion in six patients with unresectable intrahepatic metastases. Response was measured by computed tomography scan.


RESULTS
In all patients, tumors were effectively ablated. In two patients with colorectal metastases, lesions up to 8.6 cm could be created.


CONCLUSIONS
The use of watercooled multiple fiber application and hepatic inflow occlusion makes LITT an effective ablative method, expanding the treatment options for patients with large intrahepatic masses.
Veenendaal
Liesbeth M
LM
Department of Surgery, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
de Jager
Arjan
A
Stapper
Gerard
G
Borel Rinkes
Inne H M
IH
van Hillegersberg
Richard
R
D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D017075:Laser Coagulation / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014867:Water
D014867:Water