title: Antidiabetic effects of corosolic acid in KK-Ay diabetic mice.
abstract: The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.
authors.affiliation: Department of Clinical Nutrition, Suzuka University of Medical Science, Mie, Japan. miura@suzuka-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Miura
authors.forename: Naoya
authors.initials: N
authors.lastname: Ueda
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yamada
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Fukushima
authors.forename: Torao
authors.initials: T
authors.lastname: Ishida
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kaneko
authors.forename: Futoshi
authors.initials: F
authors.lastname: Matsuyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007328:Insulin; D014315:Triterpenes; C113861:corosolic acid