Addition of human chorionic gonadotropin to clomiphene citrate ovulation induction therapy does not improve pregnancy outcomes and luteal function.
In a randomized prospective study, 125 women with World Health Organization class II anovulation received 50 mg of clomiphene citrate alone (group A, n = 65) or 50 mg of clomiphene citrate plus hCG (group B, n = 60) in a total of 125 cycles during natural intercourse-advised cycles. There were no statistically significant differences between groups regarding pregnancy outcomes and midluteal P levels, but luteal phase length was longer in group A.
Yilmaz
Bulent
B
Department of Reproductive Endocrinology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. drbulentyilmaz@yahoo.com
Kelekci
Sefa
S
Savan
Kadir
K
Oral
Havva
H
Mollamahmutoglu
Leyla
L
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D000858:Anovulation / Q000188:drug therapy* / Q000503:physiopathology; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D002996:Clomiphene / Q000627:therapeutic use*; D003338:Corpus Luteum / Q000187:drug effects / Q000503:physiopathology*; D004359:Drug Therapy, Combination; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005306:Fertilization / Q000187:drug effects; D006801:Humans; D015994:Incidence; D008183:Luteal Phase; D008297:Male; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D013997:Time Factors; D014427:Twins / Q000187:drug effects
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D002996:Clomiphene; D011374:Progesterone