title: Cyano-phosphorylation of aldehydes catalyzed by a nucleophilic N-heterocyclic carbene.
abstract: The first method for cyano-phosphorylation of aldehydes with diethyl cyanophosphonate in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride and KOt-Bu, as a nucleophilic catalyst, is described.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Yuka
authors.initials: Y
authors.lastname: Maeda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kondo
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Aoyama
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D010766:Phosphorylation; D013055:Spectrophotometry, Infrared
chemical_list: C510522:1,3-bis(2,4,6-trimethylphenyl)imidazolium; D000447:Aldehydes; D006571:Heterocyclic Compounds; D006838:Hydrocarbons; D007093:Imidazoles; D007202:Indicators and Reagents; C030011:carbene; D008697:Methane