Immune reconstitution inflammatory syndrome producing atypical presentations of cryptococcal meningitis: case report and a review of immune reconstitution-associated cryptococcal infections.
Atypical presentations of cryptococcal infection have been described as manifestations of immune reconstitution in HIV-infected patients following introduction of antiretroviral therapy. We describe a patient presenting with cryptococcal meningitis as an immune reconstitution reaction 10 weeks after initiation of anti-retroviral therapy. Subclinical CSF cryptococcal infection was demonstrated and the serum cryptococcal antigen was negative.
Broom
Jennifer
J
Infectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. jennifer.broom@excite.com
Woods
Marion
M
Allworth
Anthony
A
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D013577:Syndrome