title: Immune status during odontogeneous abscesses and phlegmonas.
abstract: Odontogeneous abscesses and phlegmonas are considered as one of the most urgent problems for stomatology. By its localization and complications the patients suffering from this pathology clearly show weakening of protective mechanisms of organism. By the use of modern methods of immunologic research we studied the nonspecific, cell, humoral and specific immune status. Study of immune status proved drastic decrease in nonspecific resistance indices, namely complete phagocytosis, total number of phagocytosis and phagocytosis index, as well as decreased alpha and beta interferon concentration. Cell immunity indices show decrease of number of T-effectors, T-helpers, T-lymphocytes and T-suppressors. Study of humoral immune status proved insignificant decrease of B-lymphocytes, Ig G, Ig M and Ig A. Serologic studies showed many-fold increase of concentration of anti-staphylococcus antibodies and presence of alpha -toxin (alpha -toxin must be absent in the norm). The results obtained by us refer to necessity of carrying out therapy with immune modulators alongside with the etiologic treatment of this pathology.
authors.affiliation: Tbilisi State Medical Academy, Research Institute of Medical Biotechnology of Georgian Academy of Sciences, G. Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia.
authors.forename: I
authors.initials: I
authors.lastname: Dgebuadze
authors.forename: G
authors.initials: G
authors.lastname: Menabde
authors.forename: B
authors.initials: B
authors.lastname: Korsantia
authors.forename: S
authors.initials: S
authors.lastname: Rigvava
authors.forename: K
authors.initials: K
authors.lastname: Apridonidze
mesh_terms: D000038:Abscess / Q000209:etiology / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002481:Cellulitis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007136:Immunoglobulins / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology*; D012189:Retrospective Studies; D012307:Risk Factors; D009057:Stomatognathic Diseases / Q000150:complications*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007136:Immunoglobulins