title: Treatment of chronic rhinosinusitis and its effects on asthma.
abstract: The effects of rhinosinusitis treatment upon asthma are disputed. The first randomised prospective study of surgical compared with medical therapy of chronic rhinosinusitis in 90 patients with and without nasal polyps was previously reported. Asthma symptoms, control, forced expiratory volume in one second (FEV1), peak flow, exhaled nitric oxide, medication use and hospitalisation at 6 and 12 months from the start of the study were also monitored. This paper reports these results in 43 of those patients with concomitant asthma. Both medical and surgical treatment of chronic rhinosinusitis were associated with subjective and objective improvements in asthma. Overall asthma control improved significantly following both treatment modalities, but was better maintained after medical therapy, where improvement could also be demonstrated in the subgroup with nasal polyps. Medicine was superior to surgery with respect to a decrease in exhaled nitric oxide and increase in FEV1 in the polyp patients. Two patients noted worsening of asthma post-operatively. Improvement in upper airway symptoms, as assessed using a visual analogue scale, correlated with improvement in asthma symptoms and control. Treatment of chronic rhinosinusitis, medical or surgical, benefits concomitant asthma; that associated with nasal polyposis benefits more from medical therapy.
authors.affiliation: Tanta University Hospitals, Tanta, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: Ragab
authors.forename: G K
authors.initials: GK
authors.lastname: Scadding
authors.forename: V J
authors.initials: VJ
authors.lastname: Lund
authors.forename: H
authors.initials: H
authors.lastname: Saleh
mesh_terms: D000328:Adult; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D001993:Bronchodilator Agents / Q000494:pharmacology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D012129:Respiratory Function Tests; D012220:Rhinitis / Q000150:complications* / Q000628:therapy*; D012852:Sinusitis / Q000150:complications* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D009569:Nitric Oxide