title: [No rebound psychosis in a case of switching from clozapine to quetiapine].
abstract: OBJECTIVE
  After rapid discontinuation of clozapine treatment rebound psychosis have been reported. Preexposure of D (2) receptors to clozapine may alter their affinity to endogenous dopamine. Clozapine withdrawal may also lead dysfunctional NMDA-receptors to cause dopamine release in the striatum.
  
  
  METHODS
  We report a case of a schizophrenic patient treated with clozapine 200 mg and aripiprazole 15 mg per day. After rapid clozapine discontinuation we added quetiapine up to 700 mg daily.
  
  
  RESULTS
  No rebound psychosis occurred. Even ten weeks after switching to quetiapine the patient's condition remained stable in the Brief Psychiatric Rating Scale.
  
  
  CONCLUSIONS
  The combination of aripiprazole and quetiapine seemed to control supersensitivity effects at the D (2) receptor after clozapin withdrawal in this case.
authors.affiliation: Universitäre Psychiatrische Dienste Bern, Schweiz. Sebastian.Walther@gef.be.ch
authors.forename: Sebastian
authors.initials: S
authors.lastname: Walther
authors.forename: Dan
authors.initials: D
authors.lastname: Baciu
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000068180:Aripiprazole; D001921:Brain / Q000187:drug effects; D010054:Brief Psychiatric Rating Scale; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects*; D003987:Dibenzothiazepines / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects; D000069348:Quetiapine Fumarate; D015363:Quinolones / Q000008:administration & dosage / Q000009:adverse effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D012559:Schizophrenia / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D055502:Secondary Prevention; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D010879:Piperazines; D015363:Quinolones; D017448:Receptors, Dopamine D2; D000069348:Quetiapine Fumarate; D000068180:Aripiprazole; D003024:Clozapine