title: [Haloperidol and its side effects on the reproductive system].
abstract: Haloperidol (4'-fluoro-4-[4-Hydroxy-4-p-chlorophenylpiperidino]-Butyrophenone), a neuroleptic, drug is the first choice in the treatment of schizophrenia. Experimental studies on rats show that haloperidol, at female, causes: decreasing of the ovarian weight, inhibition of the ovulation, producing a state of distrust and stimulation of lobuloalveolar development of the mammary glands and increasing of serum prolactin levels in both male and female rats. At male rats haloperidol causes damage of Leydig cells and cells depletion of seminal lineage with sequels on the excretory ducts level and accessory genital glands. Our pilot researches confirm these observations. The aim of this paper is to suggest an attention of the side effects of haloperidol, that's its stricter controlled use.
authors.affiliation: Institut za Histologiju I Embriologiju Medicinskog Fakulte Univerziteta u Sarajevu.
authors.forename: Amira
authors.initials: A
authors.lastname: Beganović-Petrović
authors.forename: Zakira
authors.initials: Z
authors.lastname: Mornjaković
authors.forename: Esad
authors.initials: E
authors.lastname: Cosović
authors.forename: Selma
authors.initials: S
authors.lastname: Alicelebić
authors.forename: Irfan
authors.initials: I
authors.lastname: Susko
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D042361:Mammary Glands, Human / Q000187:drug effects; D010053:Ovary / Q000187:drug effects*; D051381:Rats; D013737:Testis / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol