Increased prevalence of peripheral arterial disease in osteoporotic postmenopausal women.
The aim of this study was to investigate the prevalence and correlates of peripheral arterial disease (PAD) in a population of osteoporotic postmenopausal women. The presence of PAD was assessed by ankle brachial index (ABI) in 345 ambulatory osteoporotic postmenopausal women, and in 360 community-based, age- and race-matched postmenopausal women with normal bone mineral density (BMD) (control group). PAD was detected in 63/345 (18.2%) osteoporotic women and in 14/360 (3.8%) control subjects (P < 0.0001). The mean ABI values were significantly lower in the osteoporosis group than in the control group (0.98 +/- 0.09 vs. 1.04 +/- 0.06, P < 0.0001). No difference in cardiovascular risk factors was observed between osteoporotic patients and controls, or between osteoporotic patients with and without PAD. Osteoporotic patients with PAD had lower femoral neck BMD T scores than those without PAD (-4.2 +/- 0.7 vs. -2.3 +/- 0.7, P < 0.0001). Only 4 PAD patients (5.1%) had intermittent claudication. In multivariate logistic regression analysis, factors independently associated with PAD within osteoporotic patients were lower femoral neck BMD T score (odds ratio (OR) = 0.20, 95% confidence interval (CI), 0.05-0.70, P = 0.01) and systolic blood pressure (OR = 1.02, 95% CI, 1.00-1.03, P = 0.01). This study shows for the first time an increased prevalence of PAD among osteoporotic postmenopausal women, with a lower femoral neck BMD T score being a significant independent predictor. The findings suggest that vascular status evaluation should be done in osteoporotic postmenopausal women in order to identify candidate patients for preventive and therapeutic cardiovascular interventions.
Mangiafico
Roberto Antonio
RA
Department of Internal Medicine, University of Catania School of Medicine, Clinica Medica "L. Condorelli," Ospedale Vittorio Emanuele, Via Plebiscito 628 95124, Catania, Italy. rmangiafico@tiscali.it
Russo
Enzo
E
Riccobene
Stefania
S
Pennisi
Pietra
P
Mangiafico
Marco
M
D'Amico
Ferdinando
F
Fiore
Carmelo Erio
CE
D000367:Age Factors; D000368:Aged; D001158:Arteries / Q000473:pathology; D015519:Bone Density; D002318:Cardiovascular Diseases / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D050723:Fractures, Bone; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D016017:Odds Ratio; D010024:Osteoporosis / Q000175:diagnosis / Q000473:pathology; D015663:Osteoporosis, Postmenopausal; D016491:Peripheral Vascular Diseases / Q000150:complications* / Q000453:epidemiology*; D017698:Postmenopause; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors