TGF-beta regulation by Emilin1: new links in the etiology of hypertension.
Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-beta signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-beta signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-beta signaling in the vasculature.
Raman
Malavika
M
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cobb
Melanie H
MH
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001808:Blood Vessels / Q000033:anatomy & histology / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D008562:Membrane Glycoproteins; D016212:Transforming Growth Factor beta; C030340:elastin microfibril interface located protein