Expression of L-selectin ligands in human endometrium during the implantation window after controlled ovarian stimulation for oocyte donation.
L-selectin ligands were detected in the epithelial endometrium throughout the implantation window, whereas the level of expression was significantly reduced in the donor versus control group on cycle day 19 (P<.05) in the luminal epithelium and during cycle days 19-24 in the glandular epithelium. Controlled ovarian stimulation, using the antagonist protocol in this study, is associated with a reduction of L-selectin ligand expression during the implantation window which may adversely affect the endometrial environment.
Lai
Tsung-Hsuan
TH
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zhao
Yulian
Y
Shih
Ie-Ming
IeM
Ho
Chung-Liang
CL
Bankowski
Brandon
B
Vlahos
Nikos
N
D000328:Adult; D016022:Case-Control Studies; D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D019041:L-Selectin / Q000378:metabolism*; D008024:Ligands; D008597:Menstrual Cycle; D018587:Oocyte Donation; D010062:Ovulation Induction; D010865:Pilot Projects; D013194:Staining and Labeling; D014018:Tissue Distribution
D008024:Ligands; D019041:L-Selectin