title: Cutaneous infiltration with Waldenström macroglobulinemia.
abstract: A 59-year-old Japanese man was diagnosed as Waldenström macroglobulinema. With impaired general performance and a 2-year history of pruritic eruptions that were initially confined to the forearms, but later involved the face, limbs, and trunk. A skin biopsy that was performed on the forehead showed infiltration with abnormal cells of the dermis around the central vessels. PCR analysis of the skin biopsy showed immunoglobulin heavy chain rearrangement. As the rearrangement band occurred at the same site as that of the bone marrow aspiration, skin infiltration with abnormal cells was proven.
authors.affiliation: First Department of Intenal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki City, Osaka 569-8686, Japan. in1161@poh.osaka-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Yokote
authors.forename: T
authors.initials: T
authors.lastname: Akioka
authors.forename: S
authors.initials: S
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
authors.forename: T
authors.initials: T
authors.lastname: Yamano
authors.forename: M
authors.initials: M
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Hanafusa
mesh_terms: D044466:Asian People; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000235:genetics / Q000473:pathology*