[Effect of trimitazidine on insulin resistance in patients with coronary heart disease].
OBJECTIVE
To evaluate the efficacy of trimetazidine on insulin resistance in patients with coronary heart disease (CHD).


METHODS
A cohort of 119 CHD patients were randomly divided into groups A and B receiving the same basic therapy, and the patients in group B were given additional trimetazidine 20 mg 3 times daily for 8 weeks. Before and after treatment, the changes in blood glucose, insulin levels and insulin sensitivity index were evaluated.


RESULTS
The patients in group B showed better outcome than those in group A. After 8 weeks' trimetazidine therapy, the fasting insulin and that at 2 h after oral glucose were decreased (P<0.01), and the insulin sensitivity index was improved (P<0.01).


CONCLUSIONS
Trimetazidine may produce obvious therapeutic effect on insulin resistance in CHD patients.
Cai
Jian-sheng
JS
Department of Cardiology, Second People's Hospital of Shantoucity, Shantou 515011, China. caijiansen0829@sina.com.cn
Peng
Zhi-jian
ZJ
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin; D014665:Vasodilator Agents; D014292:Trimetazidine