title: Successful use of genotypic resistance testing in HIV-1-infected individuals with detectable viraemia between 50 and 1000 copies/ml.
abstract: Traditionally an HIV viral load of over 1000 copies/ml was presumed necessary for genotypic resistance testing. We performed a retrospective analysis to assess rates of viral amplification on viral loads between 50 and 1000 copies/ml. Amplification was significantly more likely for 200-1000 copies/ml than 50-200 copies/ml; most samples amplified successfully, supporting the use of genotyping for low-level viraemia.
authors.affiliation: Department of Genitourinary and HIV Medicine, St Stephens Centre, Chelsea and Westminster Hospital, London, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Waters
authors.forename: S
authors.initials: S
authors.lastname: Mandalia
authors.forename: David
authors.initials: D
authors.lastname: Asboe
mesh_terms: D016009:Chi-Square Distribution; D004279:DNA, Viral / Q000032:analysis*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019562:Viral Load
chemical_list: D004279:DNA, Viral