title: Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: the Rotterdam Study.
abstract: OBJECTIVE
  To investigate whether arterial stiffening, one of the characteristics of the aging vascular system, is associated with orthostatic hypotension.
  
  
  METHODS
  Cross-sectional data of a cohort study in elderly men and women.
  
  
  METHODS
  We investigated the relationship between arterial stiffness and orthostatic hypotension within the framework of the Rotterdam Study, a population-based study in individuals aged 55 and older. The present study included 3362 subjects participating in the third examination phase. The carotid-femoral pulse wave velocity was used as measure of arterial stiffness. Orthostatic hypotension was assessed with blood pressure measurements in supine and standing position.
  
  
  RESULTS
  Odds ratios for orthostatic hypotension increased through quartiles of pulse wave velocity; the age, gender and mean arterial pressure adjusted odds ratio in the last quartile of pulse wave velocity was 1.45 (95% confidence interval, 1.09-1.93) when compared with the first quartile (reference). In fully adjusted models estimates remained statistically significant. In subjects with higher stiffness we observed a higher drop in blood pressure but no significant change of heart rate.
  
  
  CONCLUSIONS
  Arterial stiffness is independently associated with orthostatic hypotension. The drop in blood pressure levels and the contemporary attenuated response of heart rate to orthostatic challenge in subjects with stiffer arteries support the hypothesis that arterial stiffness may explain, at least in part, the reduced baroreflex observed in older adults.
authors.affiliation: Section of Geriatric Medicine, Department of Internal Medicine bDepartment of Epidemiology & Biostatistics, The Netherlands.
authors.forename: Francesco U S
authors.initials: FU
authors.lastname: Mattace-Raso
authors.forename: Tischa J M
authors.initials: TJ
authors.lastname: van der Cammen
authors.forename: Anneke M
authors.initials: AM
authors.lastname: Knetsch
authors.forename: Anton H
authors.initials: AH
authors.lastname: van den Meiracker
authors.forename: Maarten A D H
authors.initials: MA
authors.lastname: Schalekamp
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Jacqueline C M
authors.initials: JC
authors.lastname: Witteman
mesh_terms: D000368:Aged; D001158:Arteries / Q000502:physiology*; D001794:Blood Pressure; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011187:Posture