title: Surface modification of silica core-shell nanocapsules: biomedical implications.
abstract: In this article we present the synthesis of oil core silica shell nanocapsules with different shell thicknesses. The surface of the nanocapsules was modified with polyethyleoxide (PEO) and succinic anhydride. Two biomedical tests were then used to study the biocompatibility properties of these nanocapsules with different surface treatments, hemolysis and thromboelastography (TEG). PEO surface modification greatly reduced the damaging interactions of nanocapsules with red blood cells (RBCs) and platelets and attenuated particle size effects. It was found that the blood toxicity of charged particles increased with the acid strength on the surface. Experiments toward the assessment of detoxification of these nanocapsules in model drug overdose concentrations are currently underway.
authors.affiliation: George and Josephine Butler Polymer Laboratory, Department of Chemistry, University of Florida, P.O. Box 117200 Gainesville, 32611, USA.
authors.forename: Aleksa V
authors.initials: AV
authors.lastname: Jovanovic
authors.forename: Jason A
authors.initials: JA
authors.lastname: Flint
authors.forename: Manoj
authors.initials: M
authors.lastname: Varshney
authors.forename: Tim E
authors.initials: TE
authors.lastname: Morey
authors.forename: Donn M
authors.initials: DM
authors.lastname: Dennis
authors.forename: Randolph S
authors.initials: RS
authors.lastname: Duran
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001773:Blood Cells / Q000378:metabolism / Q000648:ultrastructure; D001792:Blood Platelets / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D013916:Thrombelastography
chemical_list: D001672:Biocompatible Materials; D011092:Polyethylene Glycols; D012822:Silicon Dioxide