title: Quinol fatty alcohols as promoters of axonal growth.
abstract: The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2,5-dimethoxyphenyl)pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n=15), shows the most potent promotion of axonal growth in the presence of both permissive and non-permissive naturally occurring substrates such as Sema3A and myelin proteins.
authors.affiliation: Laboratoire de Chimie Organique des Substances Naturelles, LC3-UMR7177 CNRS-ULP, Université Louis Pasteur, 67084 Strasbourg Cedex, France.
authors.forename: Mazen
authors.initials: M
authors.lastname: Hanbali
authors.forename: Marta
authors.initials: M
authors.lastname: Vela-Ruiz
authors.forename: Dominique
authors.initials: D
authors.lastname: Bagnard
authors.forename: Bang
authors.initials: B
authors.lastname: Luu
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001369:Axons / Q000187:drug effects*; D006873:Hydroquinones / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D006873:Hydroquinones