title: Interactions of chemicals and metal ions with proteins and role for immune responses.
abstract: Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.
authors.affiliation: Department of Dermatology, Clinical Research Group Allergology University of Freiburg, D-79104 Freiburg, Germany. stefan.martin@uniklinik-freiburg.de
authors.forename: Stefan F
authors.initials: SF
authors.lastname: Martin
authors.forename: Irmgard
authors.initials: I
authors.lastname: Merfort
authors.forename: Hermann-Josef
authors.initials: HJ
authors.lastname: Thierse
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D006241:Haptens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007477:Ions / Q000276:immunology; D008670:Metals / Q000276:immunology* / Q000378:metabolism; D009532:Nickel / Q000276:immunology; D011485:Protein Binding; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D040901:Proteomics
chemical_list: D000485:Allergens; D006241:Haptens; D007477:Ions; D008670:Metals; D011506:Proteins; D009532:Nickel