Azetidine-2-carboxylic acid in garden beets (Beta vulgaris).
Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid. In many species, including man, L-Aze is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding. In animal models of teratogenesis, it causes a wide range of malformations. The role of L-Aze in human disease has been unexplored, probably because the compound has not been associated with foods consumed by humans. Herein we report the presence of L-Aze in the garden or table beet (Beta vulgaris).
Rubenstein
Edward
E
School of Medicine, Stanford University, CA 94305, USA. gim@med.stanford.edu
Zhou
Haihong
H
Krasinska
Karolina M
KM
Chien
Allis
A
Becker
Christopher H
CH
D001383:Azetidinecarboxylic Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D027461:Beta vulgaris / Q000737:chemistry*; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D015394:Molecular Structure; D035281:Plant Tubers / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives; D013723:Teratogens / Q000737:chemistry
D013723:Teratogens; D001383:Azetidinecarboxylic Acid; D011392:Proline