title: The repair response to osteochondral implant types in a rabbit model.
abstract: Current treatments for damaged articular cartilage (i.e., shaving the articular surface, perforation or abrasion of the subchondral bone, and resurfacing with periosteal and perichondrial resurfacing) often produce fibrocartilage, or hyaline-appearing repair that is not sustained over time (Henche 1967, Ligament and Articular Cartilage Injuries. Springer-Verlag, New York, NY, pp. 157-164; Insall 1974, Clin. Orthop. 101: 61-67; Mitchell and Shepard 1976, J. Bone Joint Surg. [Am.] 58: 230-233; O'Driscoll et al. 1986, J. Bone Joint Surg. [Am.] 68: 1017-1035; 1989, Trans. Orthop. Res. Soc. 14: 145; Kim et al. 1991, J. Bone Joint Surg. [Am.] 73: 1301-1315). Autologous chondrocyte transplantation, although promising, requires two surgeries, has site-dependent and patient age limitations, and has unknown long-term donor site morbidity (Brittberg et al. 1994, N Engl. J. Med. 331: 889-895; Minas 2003, Orthopedics 26: 945-947; Peterson et al. 2003, J. Bone Joint Surg. Am. 85-A(Suppl. 2): S17-S24). Osteochondral allografts remain a widely used method of articular resurfacing to delay arthritic progression. The present study compared the histological response to four types of osteochondral implants in a rabbit model: autograft, frozen, freeze-dried, and fresh implants. Specimens implanted in the femoral groove were harvested at 6 and 12 weeks. Results showed similar restoration of the joint surface regardless of implant type, with a trend toward better repair at the later timepoint. As has been observed in other studies (Frenkel et al. 1997, J. Bone Joint Surg. 79B: 281-286; Toolan et al. 1998, J. Biomed. Mater. Res. 41: 244-250), each group in this study had at least one specimen in which a healthy-appearing surface on the implant was not well-integrated with host tissues. Although the differences were not statistically significant, freeze-dried implants at both timepoints had the best histological scores. The osteochondral grafts tested successfully restored the gross joint surface and congruity. At 12 weeks, no significant differences were observed between the various allografts and autologous osteochondral grafts.
authors.affiliation: Musculoskeletal Research Center, Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, 301 E. 17 St., New York, NY 10003, USA. sallyfrenkel@yahoo.com
authors.forename: Sally R
authors.initials: SR
authors.lastname: Frenkel
authors.forename: Erik N
authors.initials: EN
authors.lastname: Kubiak
authors.forename: Kate G
authors.initials: KG
authors.lastname: Truncale
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000009:adverse effects*; D002356:Cartilage / Q000637:transplantation*; D002358:Cartilage, Articular / Q000166:cytology / Q000473:pathology; D023421:Models, Animal; D019736:Prostheses and Implants; D011817:Rabbits; D013997:Time Factors; D014184:Transplantation, Homologous / Q000009:adverse effects; D014945:Wound Healing