Glycoconjugates of gadolinium complexes for MRI applications.
Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.
Fulton
David A
DA
Department of Chemistry, University of Durham, South Road, Durham, UK.
Elemento
Elisa M
EM
Aime
Silvio
S
Chaabane
Linda
L
Botta
Mauro
M
Parker
David
D
D005682:Gadolinium / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015394:Molecular Structure
D005682:Gadolinium; D005947:Glucose