title: Clinical analysis of vertebrobasilar dissection.
abstract: BACKGROUND
  The natural history of vertebrobasilar artery dissection (VAD) is not fully known. The purpose of this study was to review the clinical outcome of the patients with VAD, then to propose an appropriate management strategy for VAD.
  
  
  METHODS
  From 1992 to 2004, 35 VAD patients admitted to our institutes were retrospectively reviewed. There were 28 men and 7 women, whose age ranged from 4 to 67 years with a mean age of 44 years. Angiography was assessed to document the shape, and location of the dissecting aneurysm with respect to the posterior inferior cerebellar artery (PICA). A modified Rankin score was assigned for functional outcome. The functional outcome scores were analyzed according to the patient's age, gender, hypertension history, the pattern of initial manifestation, angiographic shape of VAD, angiographic location of VAD, treatment modality.
  
  
  RESULTS
  There was no statistically significant difference between the functional outcome with age, gender, trauma history and past medical history of hypertension. Of 35 patients, 22 presented with SAH, 11 with ischemic symptoms and 2 were incidentally detected. The patients without SAH had a better functional outcome than those with SAH (p = 0.029). There was statistical significance between Hunt-Hess (H-H) grade and clinical outcome (p = 0.032). The shape and location of VAD was not significantly related to the functional outcome (p = 0.294, 0.840). But all the cases of rebleeding and mortality (except one case with initially poor H-H grade) developed exclusively in patients with aneurysms. There was no statistically significant correlation between the treatment modality and the outcome (p = 0.691).
  
  
  CONCLUSIONS
  The VAD patients with SAH would be recommended to be managed by either surgical or endovascular treatment, but those without SAH, could be managed conservatively with antiplatelet therapy and/or anticoagulation.
authors.affiliation: Department of Neurosurgery, Kangwon National University College of Medicine, Chuncheon, Korea.
authors.forename: C-H
authors.initials: CH
authors.lastname: Kim
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Son
authors.forename: S H
authors.initials: SH
authors.lastname: Paek
authors.forename: M H
authors.initials: MH
authors.lastname: Han
authors.forename: J E
authors.initials: JE
authors.lastname: Kim
authors.forename: Y S
authors.initials: YS
authors.lastname: Chung
authors.forename: B J
authors.initials: BJ
authors.lastname: Kwon
authors.forename: C W
authors.initials: CW
authors.lastname: Oh
authors.forename: D H
authors.initials: DH
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001488:Basilar Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D020520:Brain Infarction / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D002533:Cerebral Angiography; D002675:Child, Preschool; D006259:Craniocerebral Trauma / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods / Q000706:statistics & numerical data; D012008:Recurrence; D012189:Retrospective Studies; D017678:Sex Distribution; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000379:methods / Q000706:statistics & numerical data; D014711:Vertebral Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D020217:Vertebral Artery Dissection / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D014715:Vertebrobasilar Insufficiency / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy