title: Hypobaric hypoxia as a tool to study pregnancy-dependent responses at the maternal-fetal interface.
abstract: Establishment of proper oxygen and nutrient supply to the fetus is essential for a successful pregnancy. The maternal-fetal interface is the site of vascular modifications, providing a conduit for the delivery of essential nutrients to the developing fetus. Pregnancy-dependent adaptive vascular responses within the uteroplacental compartment can be exaggerated by exposure to a physiological stressor such as hypoxia. A simple procedure for exposing pregnant rats and mice to hypobaric hypoxia is presented.
authors.affiliation: Institute of Maternal-Fetal Biology, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Ho-Chen
authors.forename: Rupasri
authors.initials: R
authors.lastname: Ain
authors.forename: Adam R
authors.initials: AR
authors.lastname: Alt
authors.forename: John G
authors.initials: JG
authors.lastname: Wood
authors.forename: Norberto C
authors.initials: NC
authors.lastname: Gonzalez
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Soares
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D005260:Female; D000860:Hypoxia; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D051379:Mice; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley