Synthesis and peptidyl-prolyl isomerase inhibitory activity of quinoxalines as ligands of cyclophilin A.
In search of small molecule compounds as the ligands of cyclophilin A, a series of quinoxalines were prepared, and their K(d) values of cyclophilin A and IC50 values for peptidyl-prolyl isomerase activity of cyclophilin A were tested. The results suggest that some quinoxalines are promising ligands of cyclophilin A.
Wang
Feng
F
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
Chen
Jing
J
Liu
Xuejun
X
Shen
Xu
X
He
Xuchang
X
Jiang
Hualiang
H
Bai
Donglu
D
D021984:Cyclophilin A / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D019696:Peptidylprolyl Isomerase / Q000037:antagonists & inhibitors*; D011810:Quinoxalines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D020349:Surface Plasmon Resonance
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D011810:Quinoxalines; D021984:Cyclophilin A; D019696:Peptidylprolyl Isomerase