title: Primary "breast-like" cancer of the vulva: a case report and critical review of the literature.
abstract: Ectopic mammary gland tissue in the vulva is an uncommon clinical or pathologic finding. Such ectopic tissue can be the site of the same physiologic and pathologic processes found in the normal breast. However, the occurrence of adenocarcinoma is very rare, the first case being reported by Greene in 1935. We here report the 16th case of primary "breast-like" cancer arising in the vulva, together with a critical review of the literature, in order to highlight the dilemmas of a clinical approach to this neoplasm. Clear guidelines for diagnosis and therapy are still unavailable. The main diagnostic criteria suggested by the authors of previous reports are discussed together with our own findings. The therapeutic approach to this rare malignancy is also critically reviewed. In our opinion, when diagnosis of breast-like vulvar cancer is finally confirmed, treatment and follow-up should be the same as that would be chosen in a case of orthotopic breast neoplasm.
authors.affiliation: Gynecologic Oncology Unit, S. Anna Hospital, Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Fracchioli
authors.forename: M
authors.initials: M
authors.lastname: Puopolo
authors.forename: I A Rigault
authors.initials: IA
authors.lastname: De La Longrais
authors.forename: M
authors.initials: M
authors.lastname: Scozzafava
authors.forename: F
authors.initials: F
authors.lastname: Bogliatto
authors.forename: R
authors.initials: R
authors.lastname: Arisio
authors.forename: L
authors.initials: L
authors.lastname: Micheletti
authors.forename: D
authors.initials: D
authors.lastname: Katsaros
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000628:therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil