title: The use of microorganisms in L-ascorbic acid production.
abstract: L-Ascorbic acid has been industrially produced for around 70 years. Over the past two decades, several innovative bioconversion systems have been proposed in order to simplify the long time market-dominating Reichstein method, a largely chemical synthesis by which still a considerable part of L-ascorbic acid is produced. Here, we describe the current state of biotechnological alternatives using bacteria, yeasts, and microalgae. We also discuss the potential for direct production of l-ascorbic acid exploiting novel bacterial pathways. The advantages of these novel approaches competing with current chemical and biotechnological processes are outlined.
authors.affiliation: Forschungszentrum Jülich GmbH, Institut für Biotechnologie 1, Jülich, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Bremus
authors.forename: Ute
authors.initials: U
authors.lastname: Herrmann
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bringer-Meyer
authors.forename: Hermann
authors.initials: H
authors.lastname: Sahm
mesh_terms: D001205:Ascorbic Acid / Q000096:biosynthesis*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D002384:Catalysis; D056890:Eukaryota / Q000235:genetics / Q000378:metabolism; D005285:Fermentation; D005818:Genetic Engineering / Q000379:methods*; D066298:In Vitro Techniques; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D001205:Ascorbic Acid