title: [Urinary cotinine in patients with hyperthyroidism].
abstract: The aim of our study was an analysis of cotynine, the main nicotine metabolite in the urine among hyperthyroid patients. The study group included 39 females and 4 males. The mean age was 35.59+/-14.22 yrs. (range: 18-73 yrs.; median: 32 yrs) among hyperthyroid patients suffering from: Graves-Basedow disease (GB), Graves' Ophtalmopathy (GO) and toxic nodular goiter (TNG). To evaluate the nicotine smoking intensity and ETS Environmental Tobacco Smoke, the urine analysis of cotynine level were performed. According to the statistical analysis using the Mann-Whitney test, the statistically significant difference between the level of cotynine among smokers suffering from GO and Graves-Basedow disease was revealed (p = 0.03). Similar results were obtained among the GO and TNG (p=0.02) using t-Student test with Welsch correction. To compare, there was no stastistically significant difference between the GB and TNG series (p=0.4). In the group of smoking patients with GO we found out incresed level of urine cotinine than in smoking patients with GB and TNG. We didn't found differences between GB and TNG in depends on an urine analysis of cotynine level.
authors.affiliation: Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewnetrznych w Poznaniu. agata.rat@wp.pl
authors.forename: Agata
authors.initials: A
authors.lastname: Czarnywojtek
authors.forename: Barbara
authors.initials: B
authors.lastname: Rabska-Pietrzak
authors.forename: Marek
authors.initials: M
authors.lastname: Ruchała
authors.forename: Ewa
authors.initials: E
authors.lastname: Florek
authors.forename: Wojciech
authors.initials: W
authors.lastname: Piekoszewski
authors.forename: Izabela
authors.initials: I
authors.lastname: Warmuz-Stangierska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Michałek
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sowiński
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003367:Cotinine / Q000652:urine*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000652:urine*; D008297:Male; D008875:Middle Aged
chemical_list: D003367:Cotinine