title: Array-based genomic delineation of a familial duplication 11q14.1-q22.1 associated with recurrent depression.
abstract: Detection of abnormal karyotypes with associated clinical manifestations is an important tool for the identification of genes that confer susceptibility to genetic disorders. We present a family with a duplication 11q14.1-q22.1 resulting from an unbalanced familial insertion, associated with a mild dysmorphic phenotype and mood disorders, mainly major depression. This relatively large duplication of a segment from chromosome 11 is associated with a surprisingly little physical phenotypic effect in this family. The finding of mood disorders in adult members of the family who carry the insertion supports the view that the duplication may be important for the identification of contributing gene(s) to mood disorders. Major depression is considered to be a complex trait with multiple genetic alterations interacting with environmental factors. Array-based comparative genome hybridization (array CGH) analysis with a 1 Mb genomic array, defined the duplication region that extended over 16 Mb from 11q14.1 to 11q22.1. Brain-expressed genes that map within this 16 Mb region, are considered worthy of further investigation as gene(s) contributing to the etiology of major depression.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
authors.forename: Elena
authors.initials: E
authors.lastname: Kolomietz
authors.forename: Tawfeg
authors.initials: T
authors.lastname: Ben-Omran
authors.forename: David
authors.initials: D
authors.lastname: Chitayat
authors.forename: Mimi
authors.initials: M
authors.lastname: Mah
authors.forename: Jillian
authors.initials: J
authors.lastname: Murphy
authors.forename: Gloria
authors.initials: G
authors.lastname: Nie
authors.forename: Ikuko
authors.initials: I
authors.lastname: Teshima
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics* / Q000473:pathology; D005192:Family Health; D005260:Female; D020440:Gene Duplication; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009693:Nucleic Acid Hybridization / Q000379:methods*; D010375:Pedigree; D012008:Recurrence; D017422:Sequence Analysis, DNA; D032681:Spectral Karyotyping