title: Primary gynecological neoplasms and clinical outcomes in patients diagnosed with breast carcinoma.
abstract: The purpose of this study was to quantify and describe nonmammary neoplasms (n-MN), particularly gynecological neoplasms, in a patient population previously diagnosed with breast cancer. Data were collected prospectively in our institutional review board-approved registry for patients diagnosed with infiltrating breast cancer or ductal carcinoma in situ. Patients who developed a second, n-MN were identified; neoplastic site, time to development after breast cancer, and clinical outcomes were recorded. FIGO stage was recorded for patients who developed a gynecological neoplasm. Synchronous bilateral breast cancer was defined as a second, contralateral diagnosis made within 12 months of the first and, similarly, synchronous n-MN were defined as those identified within 1 year of a breast cancer diagnosis. Outcome curves were generated using the method of Kaplan and Meier, and compared using the log-rank test. Of 4126 patients diagnosed with breast cancer, 3% developed a n-MN, the majority of which were nongynecological and asynchronous to the initial breast cancer diagnosis. Three percent of patients diagnosed with breast cancer were diagnosed with a second, n-MN. Among patients who developed a n-MN, most developed a nongynecological cancer more than 1 year after the initial breast cancer diagnosis, and their outcomes were significantly worse than those patients who did not develop a n-MN.
authors.affiliation: Department of General Surgery-Breast Center,The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. escobap@ccf.org
authors.forename: P F
authors.initials: PF
authors.lastname: Escobar
authors.forename: R
authors.initials: R
authors.lastname: Patrick
authors.forename: L
authors.initials: L
authors.lastname: Rybicki
authors.forename: N
authors.initials: N
authors.lastname: Al-Husaini
authors.forename: C M
authors.initials: CM
authors.lastname: Michener
authors.forename: J P
authors.initials: JP
authors.lastname: Crowe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary; D009820:Ohio / Q000453:epidemiology; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome