[5'-adenosine monophosphate-activated protein kinase and lifestyle-mediated diseases].
5'-adenosine monophosphate-activated protein kinase (AMPK) is an enzyme activated when cellular energy status is threatened. AMPK activates energy-providing processes, while energy-consuming processes are inhibited. AMPK is also involved in regulation of gene expression and in appetite control. Pharmacological activation of AMPK in animal models of the metabolic syndrome leads to marked amelioration of symptoms. Some antidiabetic drugs activate AMPK, and activation also occurs during physical exercise. It is likely that part of the effect of physical activity in preventing the development of diseases related to a sedentary lifestyle is due to activation of AMPK.
Richter
Erik A
EA
Københavns Universitet, Institut for Idraet, Center for Muskelforskning, Afdelingen for Human Fysiologi, København. erichter@aki.ku.dk
Kiens
Bente
B
Wojtaszewski
Jørgen F P
JF
D055372:AMP-Activated Protein Kinases; D000818:Animals; D001161:Arteriosclerosis / Q000201:enzymology; D004734:Energy Metabolism; D004789:Enzyme Activation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D008659:Metabolic Diseases / Q000201:enzymology*; D024821:Metabolic Syndrome / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000201:enzymology; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
D009097:Multienzyme Complexes; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases