title: LED-generated multifocal ERG on- and off-responses in complete congenital stationary night blindness -- a case report.
abstract: We report on the application of a light emitting diode (LED) screen to elicit multifocal ERG on- and off-responses in a patient presenting with the complete type of congenital stationary night blindness (cCSNB): A 63-years old woman was diagnosed with cCSNB by means of standard ERG procedures and dark adaptometry. To confirm this diagnosis and to investigate topographical differences of on- and off-responses a multifocal approach employing long-duration stimuli was added. Results of mfERG-testing were averaged in three groups (a central area of 7.5 degrees , a ring area of 7.5-21.9 degrees and a peripheral ring of 21.9-31.1 degrees ). When compared to normal controls (n = 4) on-responses (P1-amplitudes) were severely reduced symmetrically at all eccentricities, while off-responses showed no reduction resulting in an increased off/on-ratio. Furthermore on-latencies of P1 were delayed symmetrically at all eccentricities, whereas off-latencies were normal. To our knowledge this is the first report of multifocal on- and off-responses in a CSNB-patient. Stimulus-generation with a LED-screen provides the advantage of a stable luminance during the long-duration on-phase.
authors.affiliation: Department of Ophthamlology, University Hospital Basel, Mittlere Strasse 91, CH-4056, Basel, Switzerland. leifertd@uhbs.ch
authors.forename: Dorothee
authors.initials: D
authors.lastname: Leifert
authors.forename: Margarita G
authors.initials: MG
authors.lastname: Todorova
authors.forename: Chrisitan
authors.initials: C
authors.lastname: Prünte
authors.forename: Anja M
authors.initials: AM
authors.lastname: Palmowski-Wolfe
mesh_terms: D003623:Dark Adaptation; D004596:Electroretinography / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D009755:Night Blindness / Q000151:congenital* / Q000503:physiopathology*; D010775:Photic Stimulation / Q000295:instrumentation; D012160:Retina / Q000503:physiopathology*; D012720:Severity of Illness Index