[Influence of L-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver].
The effects of L-arginine and inhibitors of NO-synthase on the level of stable NO metabolites and nitrosothiols have been investigated under conditions of toxic damage of liver induced by CCl4. The L-arginine improved resistance of hepatic cells to damaging action of tetrachloromethane, but inhibition of NO-synthase increased hepatotropic action of CCl4. The existence of some base level of nitrosothiols, acting as a reserve pool of nitric oxide in organism, has been supposed.
Bliznetsova
G N
GN
Artem'eva
S S
SS
Retskiĭ
M I
MI
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000473:pathology; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D008099:Liver / Q000201:enzymology / Q000293:injuries / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D026403:S-Nitrosothiols / Q000378:metabolism
D004791:Enzyme Inhibitors; D026403:S-Nitrosothiols; D009569:Nitric Oxide; D001120:Arginine; D002251:Carbon Tetrachloride; D019001:Nitric Oxide Synthase