title: Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families.
abstract: In order to determine whether there is a genetic component to hip or knee joint failure due to idiopathic osteoarthritis (OA), we invited patients (probands) undergoing hip or knee arthroplasty for management of idiopathic OA to provide detailed family histories regarding the prevalence of idiopathic OA requiring joint replacement in their siblings. We also invited their spouses to provide detailed family histories about their siblings to serve as a control group. In the probands, we confirmed the diagnosis of idiopathic OA using American College of Rheumatology criteria. The cohorts included the siblings of 635 probands undergoing total hip replacement, the siblings of 486 probands undergoing total knee replacement, and the siblings of 787 spouses. We compared the prevalence of arthroplasty for idiopathic OA among the siblings of the probands with that among the siblings of the spouses, and we used logistic regression to identify independent risk factors for hip and knee arthroplasty in the siblings. Familial aggregation for hip arthroplasty, but not for knee arthroplasty, was observed after controlling for age and sex, suggesting a genetic contribution to end-stage hip OA but not to end-stage knee OA. We conclude that attempts to identify genes that predispose to idiopathic OA resulting in joint failure are more likely to be successful in patients with hip OA than in those with knee OA.
authors.affiliation: Department of Genetics and Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA.
authors.forename: H
authors.initials: H
authors.lastname: Bukulmez
authors.forename: A L
authors.initials: AL
authors.lastname: Matthews
authors.forename: C M
authors.initials: CM
authors.lastname: Sullivan
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: M J
authors.initials: MJ
authors.lastname: Kraay
authors.forename: R C
authors.initials: RC
authors.lastname: Elston
authors.forename: R W
authors.initials: RW
authors.lastname: Moskowitz
authors.forename: V M
authors.initials: VM
authors.lastname: Goldberg
authors.forename: M L
authors.initials: ML
authors.lastname: Warman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000706:statistics & numerical data; D019645:Arthroplasty, Replacement, Knee / Q000706:statistics & numerical data; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000235:genetics* / Q000601:surgery*; D020370:Osteoarthritis, Knee / Q000235:genetics / Q000601:surgery; D012307:Risk Factors; D018454:Spouses