Tacrolimus induced subacute cerebellar ataxia.
Tacrolimus is a macrolide immunosuppressant that is widely used in transplant surgery. Both mild and major neurologic side effects have been reported in patients receiving tacrolimus. Reversible posterior leukoencephalopathy syndrome is one of the major tacrolimus induced neurologic side effects. We report a case of a tacrolimus induced isolated lesion of the cerebellum with no supratentorial involvement, presenting as a subacute cerebellar ataxia, which was partially reversible upon discontinuing the tacrolimus.
Kaleyias
Joseph
J
Division of Pediatric Neurology, Department of Pediatrics, St Christopher's Hospital for Children, Erie Avenue at Front Street, Philadelphia, PA 19134, USA. kaleyias@hotmail.com
Faerber
Eric
E
Kothare
Sanjeev V
SV
D000328:Adult; D002524:Cerebellar Ataxia / Q000139:chemically induced* / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D016559:Tacrolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016559:Tacrolimus