title: Antiviral and antituberculous activity of Helichrysum melanacme constituents.
abstract: Bioassay guided fractionation of the acetonic extract of Helichrysum melanacme using human Influenza virus type A and a drug-sensitive strain of Mycobacterium tuberculosis in vitro resulted in the isolation of 2 4',6'-trihydroxy-3'-prenylchalcone (1) and 4',6',5''-trihydroxy-6'',6''-dimethyldihydropyrano[2'',3''-2',3'] chalcone (2) as active constituents. 3-O-methylquercetin and quercetin were also isolated but were inactive against the microorganisms tested in this study.
authors.affiliation: Department of Botany, University of Pretoria, Pretoria 0002, South Africa. namrita@postino.up.ac.za
authors.forename: N
authors.initials: N
authors.lastname: Lall
authors.forename: A A
authors.initials: AA
authors.lastname: Hussein
authors.forename: J J M
authors.initials: JJ
authors.lastname: Meyer
mesh_terms: D000096:Acetone / Q000737:chemistry; D000995:Antitubercular Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D036562:Helichrysum / Q000737:chemistry*; D009980:Influenza A virus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D018520:Plant Shoots / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C511109:2,4',6'-trihydroxy-3'-prenylchalcone; C511110:4',6',5''-trihydroxy-6'',6''-dimethyldihydropyrano(2'',3''-2',3') chalcone; D000995:Antitubercular Agents; D000998:Antiviral Agents; D047188:Chalcones; D011714:Pyrans; D000096:Acetone