Higher distant failure in young age tongue cancer patients.
The objective of this study was to understand if the age of the patient at onset of tongue cancer was an adverse factor for patient survival and distant metastasis (DM). Data were collected from a retrospective database (January 1996-June 2003, n=296). Local control rates, neck control rates, DM rates, and survival curves were assessed by the Kaplan-Meier method. Prognostic variables were assessed by the log-rank test and Cox proportional hazards regression method. For the young group (<or=40 years, n=76), a significantly higher 5-year DM rate (p=0.014) was noted than the elderly group (>40 years, n=220). No significant differences were seen in 5-year local and neck controls, disease-free, disease-specific and overall survivals between these two groups. We concluded that being <or=40 years of age at the onset of disease is a significant adverse factor for DM in tongue cancer.
Liao
Chun-Ta
CT
Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital at Taipei, Linkou Medical Center, and Department of Public Health, Chang Gung University, Taiwan.
Wang
Hung-Ming
HM
Hsieh
Ling-Ling
LL
Chang
Joseph Tung-Chieh
JT
Ng
Shu-Hang
SH
Hsueh
Chuen
C
Lee
Li-Yu
LY
Lin
Chih Hung
CH
Chen
I-How
IH
Kang
Chung-Jan
CJ
Huang
Shiang-Fu
SF
Yen
Tzu-Chen
TC
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001114:Areca / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D004812:Epidemiologic Methods; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012907:Smoking / Q000009:adverse effects; D014062:Tongue Neoplasms / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D017211:Treatment Failure; D016896:Treatment Outcome