Sudden cardiac death not related to coronary atherosclerosis.
Sudden cardiac death (SCD) accounts for approximately 300,000 cardiac events in the United States each year, representing an overall incidence of 0.1-0.2% per year. Although the vast majority of these may be attributed to coronary atherosclerosis, a wide variety of nonatherosclerotic-related cardiac diseases have been associated with SCD. This review highlights three general categories of cardiac disease not related to atherosclerosis: the cardiomyopathies, inflammatory myocardial diseases, and ion channel disorders. The important role played by genetics in some of these cardiovascular diseases is presented as well as toxic and drug-related etiologies.
Ladich
Elena
E
CVPath, International Registry of Pathology, Inc., Gaithersburg, MD 20878, USA.
Virmani
Renu
R
Burke
Allen
A
D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D009202:Cardiomyopathies / Q000209:etiology / Q000401:mortality / Q000473:pathology*; D002423:Cause of Death; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000401:mortality; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007473:Ion Channels; D009205:Myocarditis / Q000209:etiology / Q000401:mortality / Q000473:pathology; D014481:United States / Q000453:epidemiology
D000889:Anti-Arrhythmia Agents; D007473:Ion Channels