title: Proceedings of the 4th Georg Rajka International Symposium on Atopic Dermatitis, Arcachon, France, September 15-17, 2005.
abstract: The 4th Georg Rajka International Symposium on Atopic Dermatitis presented a comprehensive view of our current understanding and management of atopic dermatitis (AD). These proceedings highlight contributions related to the history of AD doctrines; genetic and epigenetic background; epidemiology; maturation of the immune system; infection and innate-adaptive immunity; epidermal inflammation, including neurogenic inflammation and pruritus; animal models; skin barrier; evidence-based therapy and education programs; prognostic and severity markers; and allergy testing. Several studies in animal models and human subjects point to impaired skin barrier function as a primary defect that facilitates the effect of environmental factors and immune dysregulation found in AD. The new frontier in AD therapy should, in the near future, reflect our better understanding of the skin barrier. The influence of environmental factors on the skin and other epithelial barriers in the perinatal period needs to be better understood to implement appropriate prevention programs.
authors.affiliation: Department of Dermatology and Pediatric Dermatology, CHU de Bordeaux, Bordeaux, France. alain.taieb@chu-bordeaux.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Taïeb
authors.forename: Jon
authors.initials: J
authors.lastname: Hanifin
authors.forename: Kevin
authors.initials: K
authors.lastname: Cooper
authors.forename: Jan D
authors.initials: JD
authors.lastname: Bos
authors.forename: Genji
authors.initials: G
authors.lastname: Imokawa
authors.forename: Tim J
authors.initials: TJ
authors.lastname: David
authors.forename: Johannes
authors.initials: J
authors.lastname: Ring
authors.forename: Carlo
authors.initials: C
authors.lastname: Gelmetti
authors.forename: Alexander
authors.initials: A
authors.lastname: Kapp
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
authors.forename: Yves
authors.initials: Y
authors.lastname: de Prost
authors.forename: Ulf
authors.initials: U
authors.lastname: Darsow
authors.forename: Thomas
authors.initials: T
authors.lastname: Werfel
authors.forename: David
authors.initials: D
authors.lastname: Atherton
authors.forename: Arnold P
authors.initials: AP
authors.lastname: Oranje
mesh_terms: D000818:Animals; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D007223:Infant; D051379:Mice; D008810:Mice, Inbred C57BL; D012867:Skin / Q000276:immunology / Q000382:microbiology