Thrombotic complications in von Willebrand disease.
Thrombotic events occur rarely in patients with von Willebrand disease (VWD). In this review we analyze the data reported in the literature, selected through a PubMed search, on thrombotic complications in VWD patients. On the basis of this analysis, we conclude that thrombotic complications in VWD patients often have a multi-factorial pathogenesis resulting from a complex interaction between acquired (coagulation factor replacement, surgery, cardiovascular risk factors) and/or inherited (thrombophilic gene mutations) prothrombotic risk factors.
Franchini
Massimo
M
Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@mail.univr.it
D001779:Blood Coagulation Factors / Q000235:genetics; D006801:Humans; D039781:PubMed; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D014842:von Willebrand Diseases / Q000150:complications* / Q000235:genetics / Q000628:therapy
D001779:Blood Coagulation Factors