title: Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury.
abstract: Traumatic brain injury (TBI) frequently results in cerebrovascular lesions that may increase secondary damage and cause neuropsychological impairment. Previous studies suggest an association among the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE), cardiovascular disease, and cognitive performance. Clinical and experimental studies have demonstrated the beneficial effects of ACE inhibitor treatment on vascular injury, hypertension, brain ischemia, and cognitive functioning. In a sample of 73 moderate and severe TBI patients, the authors assessed whether cognitive sequelae differed in relation to the ACE I/D polymorphism. D allele carrier patients performed worse than those with I/I polymorphism on tests involving attention and processing speed. Findings suggest that the physiopathological changes associated with TBI may have greater consequences in ACE D allele carriers.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS C/Casanova, 143 08036 Barcelona. marizago7@docd4.ub.edu
authors.forename: Mar
authors.initials: M
authors.lastname: Ariza
authors.forename: Maria Del
authors.initials: MD
authors.lastname: Matarin
authors.forename: Carme
authors.initials: C
authors.lastname: Junqué
authors.forename: María
authors.initials: M
authors.lastname: Mataró
authors.forename: Immaculada
authors.initials: I
authors.lastname: Clemente
authors.forename: Pedro
authors.initials: P
authors.lastname: Moral
authors.forename: María
authors.initials: M
authors.lastname: Antonia Poca
authors.forename: Angel
authors.initials: A
authors.lastname: Garnacho
authors.forename: Juan
authors.initials: J
authors.lastname: Sahuquillo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D020087:Alu Elements / Q000235:genetics*; D020208:Brain Injury, Chronic / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002886:Chromosomes, Human, Pair 17; D004251:DNA Transposable Elements / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D015600:Glasgow Coma Scale; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011597:Psychomotor Performance
chemical_list: D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A