A search to predict potential for drug-induced cardiovascular toxicity.
This is a brief review of properties of cardiovascular function that should be considered for interrogation in studies of toxicology and/or safety pharmacology for non-cardiologists and non-physiologists. Since concern over the rarely occurring, unusual, and drug-induced tachycardia, Torsade de pointes, is a leading cause for cessation of development of potential drugs and for removal of drugs from the market, therefore, the toxic manifestation of drugs will be emphasized. The putative origin of torsade de pointes, and the origin of the electrocardiogram and electrocardiographic features of ventricular arrhythmias will be discussed.
Hamlin
Robert L
RL
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA. hamlin.1@osu.edu
D000818:Animals; D000830:Animals, Laboratory; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D011237:Predictive Value of Tests; D011817:Rabbits; D013610:Tachycardia / Q000139:chemically induced / Q000503:physiopathology; D018675:Toxicity Tests / Q000379:methods*