Lessons learned from molecular defects in nuclear factor kappaB dependent signaling.
Nuclear factor (NF) kappaB is a ubiquitously expressed transcription factor that plays critical roles in normal development and inflammation. Characterization of naturally occurring defects in signaling pathways leading to activation of NFkappaB, complemented by mouse knockout models, has demonstrated the vital role of NFkappaB in normal host defense.
McDonald
Douglas R
DR
Division of Immunology, Children's Hospital, Boston and Department of Pediatrics, Harvard Medical School, Karp Family Research Building, One Blackfan Circle, Boston, MA 02115, USA.
Janssen
Riny
R
Geha
Raif
R
D000818:Animals; D004476:Ectodermal Dysplasia / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D051550:I-kappa B Kinase / Q000235:genetics; D020672:I-kappa B Proteins / Q000235:genetics; D007110:Immunity, Active; D007113:Immunity, Innate; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D016328:NF-kappa B / Q000172:deficiency / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
D020672:I-kappa B Proteins; D016328:NF-kappa B; D051550:I-kappa B Kinase