title: Efficacy of inactivated trivalent influenza vaccine in alleviating the febrile illness of culture-confirmed influenza in children in the 2000-2001 influenza season.
abstract: During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1%), culture positive for influenza were enrolled for analysis. The numbers of patients for A/H1N1 and A/H3N2 were insufficient for statistical analysis. For influenza B the odds ratio for vaccinated children to have a maximum fever exceeding 39.5 degrees C was 0.52 (95% CI, 0.30-0.92) Our findings suggest modest impact of influenza vaccination on limiting severity of disease symptoms.
authors.affiliation: Nagai Pediatric Clinic, 2-20 Akanechou, Takamatsu, Kagawa 760-0002, and Pediatrics and Child Health, Kurume University Medical Center, Fukuoka, Japan. makoto-kamada@hokkaido.med.or.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Kamada
authors.forename: Takao
authors.initials: T
authors.lastname: Nagai
authors.forename: Takuji
authors.initials: T
authors.lastname: Kumagai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Igarashi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ihara
authors.forename: Teruo
authors.initials: T
authors.lastname: Okafuji
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ochiai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakiyama
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Shimomura
authors.forename: Eitaro
authors.initials: E
authors.lastname: Suzuki
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Torigoe
authors.forename: Chiaki
authors.initials: C
authors.lastname: Miyazaki
authors.forename: Akiko
authors.initials: A
authors.lastname: Miyata
authors.forename: Kenji
authors.initials: K
authors.lastname: Yuri
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Ito
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nakayama
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kase
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Okuno
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005334:Fever / Q000517:prevention & control; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000302:isolation & purification; D009981:Influenza B virus / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D007564:Japan / Q000453:epidemiology; D013997:Time Factors; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated