title: The ASK1-MAP kinase pathways in immune and stress responses.
abstract: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.
authors.affiliation: Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Matsuzawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Noguchi
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Takeda
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ichijo
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology / Q000378:metabolism; D004330:Drosophila / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000378:metabolism; D048848:MAP Kinase Kinase Kinase 5 / Q000737:chemistry / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000276:immunology / Q000502:physiology*; D013312:Stress, Physiological / Q000276:immunology / Q000503:physiopathology*; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D051193:Toll-Like Receptors; D048848:MAP Kinase Kinase Kinase 5