Efficient synthesis of episulfones and of SO2 with any variation of oxygen isotopes using HOF.CH3CN.
[reaction: see text] Episulfones are quite unstable and difficult to make compounds. HOF.CH(3)CN, a powerful oxygen transfer agent operating under very mild conditions, was successfully employed in converting episulfides to episulfones. Unlike other oxidizing agents, no episulfoxides were formed under standard conditions. Reacting H(18)OF.CH(3)CN with either an episulfide or an episulfoxide leads to the corresponding episulfone with all combinations of oxygen isotopes. Decomposition of such episulfones gives any desirable variation of S(18)O(x)()O (x = 16, 18).
Harel
Tal
T
School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
Amir
Elizabeta
E
Rozen
Shlomo
S