title: Aggressive surgical and chemotherapeutic treatment of advanced pancreatoblastoma associated with tumor thrombus in portal vein.
abstract: A 3-year-old boy had pancreatoblastoma arising in the pancreatic head and body, with metastasis in the mesenteric lymph nodes, tumor thrombus in the portal vein, and a small metastatic lesion in the left lung. After preoperative chemotherapy, aggressive surgical treatment including resection and reconstruction of the portal and superior mesenteric veins was performed. Postoperative chemotherapy was followed by high-dose chemotherapy and rescue with peripheral blood stem cell transplantation, and he has now been well for 6 years. This is the first surviving pediatric case of advanced pancreatoblastoma treated by aggressive surgical therapy including reconstruction of the portal vein and high-dose chemotherapy followed by peripheral blood stem cell transplantation.
authors.affiliation: Department of Pediatric Surgery, Nara Hospital, Kinki University School of Medicine, Ikoma, Nara 630-0293, Japan. yonekura@nara.med.kindai.ac.jp
authors.forename: Takeo
authors.initials: T
authors.lastname: Yonekura
authors.forename: Takuya
authors.initials: T
authors.lastname: Kosumi
authors.forename: Masanori
authors.initials: M
authors.lastname: Hokim
authors.forename: Shinji
authors.initials: S
authors.lastname: Hirooka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kitayama
authors.forename: Akio
authors.initials: A
authors.lastname: Kubota
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D010496:Pericardium / Q000637:transplantation; D036102:Peripheral Blood Stem Cell Transplantation; D011169:Portal Vein / Q000473:pathology / Q000601:surgery*; D013927:Thrombosis / Q000209:etiology* / Q000601:surgery