title: Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor.
abstract: Trypsinogens and PSTI/TATI/SPINK1 are expressed, usually together, at high levels by the pancreas but also by many other normal and malignant tissues. The present review describes studies on the expression and putative functions of trypsinogens and PSTI/TATI/SPINK1 in the human body. The clinical aspects are discussed, including the correlations between expression of trypsinogens and PSTI/TATI/SPINK1 in tissues, serum, and urine of patients with pancreatitis or cancer and clinicopathological characteristics, i.e., the roles of trypsinogens and PSTI/TATI/SPINK1 in spontaneous and hereditary pancreatitis, tumor progression, and prognosis.
authors.affiliation: Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Annukka
authors.initials: A
authors.lastname: Paju
authors.forename: Ulf-Håkan
authors.initials: UH
authors.lastname: Stenman
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D010179:Pancreas / Q000201:enzymology; D010190:Pancreatic Neoplasms / Q000201:enzymology; D010195:Pancreatitis / Q000175:diagnosis / Q000201:enzymology*; D014357:Trypsin / Q000378:metabolism; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000032:analysis / Q000378:metabolism*; D014362:Trypsinogen / Q000032:analysis / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D014359:Trypsin Inhibitor, Kazal Pancreatic; D014362:Trypsinogen; D014357:Trypsin