[Classical and novel molecular prognostic factors in ovarian cancers].
Development of molecular biology techniques allows at present for a more rapid and more reliable diagnosis of ovarian cancers. Present paper describes genetic alterations which predispose to development of ovarian cancer and mutations which play principal role in pathogenesis of sporadic cases of the disease. Prognostic significance has also been outlined of expression of cyclooxygenase 2, ligands of P-selectin and inhibitors of complement in cells of ovarian cancer as well as their potential therapeutic significance. A separate chapter has been devoted to the potential and achievements gained using DNA microarray techniques.
Zasławski
Ryszard
R
Szpital Wojewódzki w Legnicy, Oddzial Ginekologiczno-Połozniczy.
Surowiak
Paweł
P
Zabel
Maciej
M
D051927:CD24 Antigen / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D051916:Membrane Cofactor Protein / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010051:Ovarian Neoplasms / Q000235:genetics*; D011379:Prognosis
D051927:CD24 Antigen; D051916:Membrane Cofactor Protein; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human