Isolated bone metastasis in testicular germ cell tumors: a case report and review of the literature.
BACKGROUND
In testicular germ cell tumors (GCT), bone metastases are usually seen late in the disease progress and are almost always associated with involvement of other sites. However, isolated bone metastasis is an extremely rare finding in these patients.


METHODS
A 43- year-old man was admitted to the neurosurgery department of our hospital suffering from dysarthria, ataxia, headaches and a progressive swelling above the parietooccipital region of the skull. Radiological, biochemical and pathologic tests showed that the lesion of the skull was an isolated skull metastasis as an initial manifestation of nonseminomatous GCT of the testis.


CONCLUSIONS
When a young patient presents with bone pain or painless swelling, even if it is an unusual site and isolated, testicular GCT should be considered as a differential diagnosis, as these lesions could be the first evidence of metastatic GCT.
Uygun
Kazim
K
Medical Oncology Department, Medical Faculty, Trakya University, Edirne, Turkey. kzuygun@hotmail.com
Karagol
Hakan
H
Kocak
Zafer
Z
Cicin
Irfan
I
Yalcin
Omer
O
Caloglu
Murat
M
Simsek
Osman
O
Harmandar
Ferda Akbay
FA
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D009777:Occipital Bone / Q000473:pathology / Q000601:surgery; D009919:Orchiectomy; D010294:Parietal Bone / Q000473:pathology / Q000601:surgery; D012888:Skull Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013737:Testis / Q000473:pathology