title: Fatty acids in serum cholesteryl esters in relation to asthma and lung function in children.
abstract: BACKGROUND
  Dietary fatty acid intake has been proposed to contribute to asthma development with n-6 polyunsaturated fatty acids (PUFA) having a detrimental and n-3 PUFA a protective effect.
  
  
  OBJECTIVE
  The aim of our analysis was to explore the relationship between fatty acid composition of serum cholesteryl esters as marker of dietary intake and prevalence of asthma, impaired lung function and bronchial hyper-responsiveness in children.
  
  
  METHODS
  The study population consisted of 242 girls and 284 boys aged 8-11 years, living in Munich, Germany. Data were collected by parental questionnaire, lung function measurement and skin prick test according to the International Study of Asthma and Allergies in Childhood phase II protocol. Confounder-adjusted odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association between quartiles of fatty acid concentration and health outcomes with the first quartile as reference.
  
  
  RESULTS
  n-3 PUFA: levels of eicosapentaenoic acid were not related to asthma and impaired lung function. Linolenic acid levels were positively associated with current asthma (OR for fourth quartile 3.35, 95% CI 1.29-8.66). Forced expiratory volume in 1 s (FEV(1)) values decreased with increasing levels of linolenic acid (p for trend=0.057). n-6 PUFA: there was a strong positive association between arachidonic acid levels and current asthma (OR(4th quartile) 4.54, 1.77-11.62) and a negative association with FEV(1) (P=0.036). In contrast, linoleic acid was negatively related to current asthma (OR(4th quartile) 0.34, 0.14-0.87) and FEV(1) values increased with increasing levels of linoleic acid (P=0.022). The ratio of measured n-6 to n-3 PUFA as well as levels of palmitic and oleic acid were not consistently related to asthma or lung function.
  
  
  CONCLUSIONS
  Our data do not support the hypothesis of a protective role of n-3 PUFA. Elevated arachidonic acid levels in children with asthma may be because of a disturbed balance in the metabolism of n-6 PUFA or may be secondary to inflammation in these patients.
authors.affiliation: Department of Epidemiology, University of Ulm, Ulm, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Bolte
authors.forename: I
authors.initials: I
authors.lastname: Kompauer
authors.forename: M
authors.initials: M
authors.lastname: Fobker
authors.forename: P
authors.initials: P
authors.lastname: Cullen
authors.forename: U
authors.initials: U
authors.lastname: Keil
authors.forename: E
authors.initials: E
authors.lastname: Mutius
authors.forename: S K
authors.initials: SK
authors.lastname: Weiland
mesh_terms: D016718:Arachidonic Acid / Q000097:blood; D001249:Asthma / Q000097:blood* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002788:Cholesterol Esters / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D019301:Oleic Acid / Q000097:blood; D019308:Palmitic Acid / Q000097:blood; D014797:Vital Capacity
chemical_list: D002788:Cholesterol Esters; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D016718:Arachidonic Acid; D019301:Oleic Acid; D019308:Palmitic Acid