A novel device for in vitro isometric tension recordings of cylindrical artery segments.
There are few instruments specifically designed to measure circumferential force generated by ring segments of arteries in vitro. Typical limitations of some existing machines include poor isometry, large organ bath volume or difficult sample mounting. The authors designed, built and tested a device for isometric tension recording of force developed by rings of arteries in vitro. It is suitable for assessment of arteries from 0.3 to 3 mm in diameter and allows measurements of forces in the range 0-20 g on eight rings simultaneously. The organ baths are independently regulated in temperature, stirred, disposable and have a minimum useable volume of only 1.2 mL.
Young
Joseph B
JB
Section of Neurosurgery, MC3026, Department of Surgery, University of Chicago Medical Center and Pritzker School of Medicine, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Jahromi
Babak S
BS
Zhang
Zhen-Du
ZD
Macdonald
R Loch
RL
D000818:Animals; D001488:Basilar Artery / Q000502:physiology*; D004285:Dogs; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007537:Isometric Contraction / Q000502:physiology*; D008846:Micromanipulation / Q000295:instrumentation* / Q000379:methods; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009924:Organ Culture Techniques / Q000295:instrumentation*; D013314:Stress, Mechanical; D014159:Transducers