title: Immunologic responses against hydrolyzed soy protein in dogs with experimentally induced soy hypersensitivity.
abstract: OBJECTIVE
  To assess whether dogs with experimentally induced type I hypersensitivity against soy protein would respond to soy hydrolysate and develop cutaneous or gastrointestinal tract reactions after intradermal and oral challenge exposure.
  
  
  METHODS
  12 naïve Beagle pups (9 sensitized and 3 control dogs).
  
  
  METHODS
  9 dogs were sensitized against soy protein by administration of allergens during a 90-day period. After the sensitization period, serum concentrations of soy-specific IgE were determined and an intradermal test was performed to confirm the dogs were sensitized against soy protein. An intradermal challenge test and an oral challenge test with native and hydrolyzed soy protein were conducted on 6 sensitized and 2 control dogs.
  
  
  RESULTS
  High serum concentrations of soy-specific IgE and positive results for the intradermal test were observed for the 9 sensitized dogs after completion of the sesitization process. Sensitized dogs challenge exposed with hydrolyzed soy protein had a reduced inflammatory response after intradermal injection and no clinical response after an oral challenge exposure, compared with responses after intradermal and oral challenge exposure with native soy protein.
  
  
  CONCLUSIONS
  Soy-sensitized dogs did not respond to oral administration of hydrolyzed soy protein. Thus, hydrolyzed soy protein may be useful in diets formulated for the management of dogs with adverse reactions to food.
authors.affiliation: Department de Farmacologia, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain, 08193.
authors.forename: Anna
authors.initials: A
authors.lastname: Puigdemont
authors.forename: Pilar
authors.initials: P
authors.lastname: Brazís
authors.forename: Montserrat
authors.initials: M
authors.lastname: Serra
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fondati
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced* / Q000276:immunology*; D004285:Dogs; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D008297:Male; D030262:Soybean Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*
chemical_list: D030262:Soybean Proteins; D007073:Immunoglobulin E