What are the relevant parameters for the geometrical optimization of an implantable bioartificial pancreas?
A sphere within a cylinder representing the islet encapsulated in a hollow fiber can model an implantable bioartificial pancreas. Based on a finite element model for insulin response to a glucose load in the presence of various oxygen supplies, the present study aimed at pointing out the major parameters influencing this secretion. The computational results treated with the Taguchi method clearly demonstrated that geometrical parameters (fiber length and islet density) should be precisely optimized for an enhanced insulin response. This requires the collection of more relevant experimental data concerning the islet oxygen consumption. Moreover, the relative errors on glucose consumption or insulin secretion by the islets do not seem to affect the whole optimization process, which should focus on the oxygen supply to islets.
Dulong
Jean-Luc
JL
Technological University of Compiègne, UMR 6600 CNRS, Department of Biological Engineering, Compiègne, France.
Legallais
Cécile
C
D021522:Bioartificial Organs; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D002478:Cells, Cultured; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis / Q000379:methods; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000502:physiology*; D016381:Islets of Langerhans Transplantation / Q000295:instrumentation* / Q000379:methods; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D010179:Pancreas / Q000502:physiology; D019397:Pancreas, Artificial
D007328:Insulin; D005947:Glucose; D010100:Oxygen