title: The prevalence of chronic critical lower limb ischaemia in a population of 20,000 subjects 40-69 years of age.
abstract: OBJECTIVE
  To study the prevalence and possible risk factors for chronic critical lower limb ischaemia (CLI) in an unselected population of 20,291 Norwegian men and women 40-69 years of age.
  
  
  METHODS
  Between 1995 and 1997, all residents 20 years or older in Nord-Trøndelag County, Norway, were invited to participate in a population study (the HUNT 2 Study). Among the 71.2% who attended, 20,291 participants 40-69 years of age responded to questions specifically aimed at identifying CLI. Chronic critical ischaemia was suspected if participants indicated: (1) ulcers on toes, foot or ankle that had failed to heal and/or; (2) persistent pain in the forefoot while in the supine position, but with relief of this pain when standing up. Using logistic regression analyses, we estimated the association between the prevalence of CLI and smoking, diabetes mellitus, previous cardiovascular events, blood lipids and glucose levels, and body mass index (BMI).
  
  
  RESULTS
  The age-adjusted prevalence of CLI was 0.26% among men and 0.24% among women, and there was no gender difference in any age group (age-adjusted OR = 0.91, 95% CI = 0.52-1.58). The presence of increased age, diabetes mellitus, angina pectoris, high triglyceride levels, and high BMI were all independently associated with higher prevalence of CLI.
  
  
  CONCLUSIONS
  The prevalence of CLI was 0.24%, similar for both genders, and increased with age. Risk factors usually seen in atherosclerotic patients were associated with suspected CLI.
authors.affiliation: Department of Circulation and Medical Imaging, Faculty of Medicine, University Medical Center, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.
authors.forename: S A
authors.initials: SA
authors.lastname: Jensen
authors.forename: L J
authors.initials: LJ
authors.lastname: Vatten
authors.forename: H O
authors.initials: HO
authors.lastname: Myhre
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000787:Angina Pectoris / Q000453:epidemiology; D015992:Body Mass Index; D002908:Chronic Disease; D015986:Confounding Factors, Epidemiologic; D003430:Cross-Sectional Studies; D003925:Diabetic Angiopathies / Q000453:epidemiology; D005260:Female; D006306:Health Surveys; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides