title: Holmium laser enucleation of the prostate in patients on anticoagulant therapy or with bleeding disorders.
abstract: OBJECTIVE
  We evaluated the safety and efficacy of HoLEP in patients on anticoagulation with significant obstructive symptoms secondary to BPH refractory to medical therapy.
  
  
  METHODS
  From May 1999 to October 2004, 83 patients with a mean age of 76.6 years who had symptomatic BPH and were on chronic oral anticoagulant therapy or had bleeding disorders underwent HoLEP. Mean preoperative prostate size estimated by transrectal ultrasound was 82.4 cc (range 25 to 222). A total of 14 patients underwent HoLEP without oral anticoagulant withdrawal, 34 underwent surgery with low molecular weight heparin substitution and 33 stopped anticoagulants before surgery, including 8 on antiplatelet therapy. All patients were assessed preoperatively, and 1, 3, 6 and 12 months after surgery.
  
  
  RESULTS
  HoLEP was performed successfully in all patients with a mean enucleation time of 86.5 minutes (range 35 to 210). Mean morcellation time was 20.1 minutes (range 3 to 100). Peak urinary flow, post-void residual urine, International Prostate Symptom Score and quality of life score were significantly improved by 1 month after surgery and they continued to improve during subsequent followup. One patient required intraoperative platelet transfusion and 7 required blood transfusion early in the postoperative period due to hematuria coinciding with restarting oral anticoagulant therapy. Mean preoperative and postoperative hemoglobin was 13.5 (range 8.3 to 16.4) and 12.2 gm/dl (range 5.3 to15.4), respectively (p <0.0001). There were no major operative or postoperative complications, or thromboembolic events.
  
  
  CONCLUSIONS
  HoLEP is a safe and effective therapeutic modality in patients on anticoagulation with symptomatic BPH refractory to medical therapy.
authors.affiliation: Division of Urology, McGill University School of Medicine, Montreal, Quebec, Canada.
authors.forename: Ehab
authors.initials: E
authors.lastname: Elzayat
authors.forename: Enmar
authors.initials: E
authors.lastname: Habib
authors.forename: Mostafa
authors.initials: M
authors.lastname: Elhilali
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000188:drug therapy*; D006695:Holmium; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods*; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D014524:Urethral Obstruction / Q000150:complications* / Q000209:etiology / Q000601:surgery*
chemical_list: D000925:Anticoagulants; D006695:Holmium