title: [Study on percutaneous absorption of Xuetie Dingchuan Plaster].
abstract: OBJECTIVE
  To filtrate prescription of the adhesive plaster, kind and amount of percutaneous absorption reagent, etc.
  
  
  METHODS
  In vitro percutaneous absorption of Xuetie Dingchuan Plaster was studied by HPLC using magnolin as the content of the marker substance, in the condition of equal effective component of samples, drawing graphs with time as abscissa and area of peak as ordinate.
  
  
  RESULTS
  40% ethanol was used as receptor liquid, prescription with Polyethylene Glycol 6000 as bases, azone as percutaneous absorption reagent. The amount of azone was 1.8%.
  
  
  CONCLUSIONS
  The prescription of Xuetie Dingchuan Plaster, with 1.8% azone as percutaneous absorption reagent, and Polyethylene Glycol 6000 as bases, is preferable.
authors.affiliation: Research and Development Center of New Drugs and Marine Medication, Nanjing 210029.
authors.forename: Shuping
authors.initials: S
authors.lastname: Sun
authors.lastname: Di Liuqing
authors.forename: Yaozhou
authors.initials: Y
authors.lastname: Huang
authors.forename: Meihua
authors.initials: M
authors.lastname: Ni
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001381:Azepines / Q000008:administration & dosage / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000493:pharmacokinetics*; D000431:Ethanol; D005260:Female; D066298:In Vitro Techniques; D017705:Lignans; D008031:Lignin / Q000031:analogs & derivatives / Q000378:metabolism; D008081:Liposomes; D008297:Male; D051379:Mice; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D001381:Azepines; D004365:Drugs, Chinese Herbal; D017705:Lignans; D008081:Liposomes; C094148:magnolin; D000431:Ethanol; D008031:Lignin; D004121:Dimethyl Sulfoxide