title: Acute coronary syndrome induced by oral capecitabine.
abstract: A 41-year-old woman who was undergoing oral chemotherapy with capecitabine for metastatic breast cancer presented with recurrent episodes of chest pain associated with electrocardiographic signs of diffuse ST segment elevation. After spontaneous pain relief, the electrocardiogram showed ischemic evolution in the anterior precordial leads. Coronary and ventricular angiography, performed 24 h later, showed normal coronary arteries and normal left ventricular function. After therapy with capecitabine was discontinued, the patient did not experience further episodes of chest pain. After a nine-month follow-up, she remains alive, with a good performance status and without clinical evidence of persistent ischemia.
authors.affiliation: Cardiology Unit, European Institute of Oncology, Milan, Italy. daniela.cardinale@ieo.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Cardinale
authors.forename: Alessandro
authors.initials: A
authors.lastname: Colombo
authors.forename: Nicola
authors.initials: N
authors.lastname: Colombo
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000789:Angina, Unstable / Q000139:chemically induced* / Q000175:diagnosis; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D013577:Syndrome
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil