title: 1H magnetic resonance spectroscopy at 3 T in cryptogenic and mesial temporal lobe epilepsy.
abstract: The objectives of this work were to compare concentrations of N-acetylaspartate (NAA), glutamate (Glu), glutamine (Gln), Glx (=Glu + Gln), myo-inositol (mI), total creatine (Cre) and other metabolites in the temporal lobes of patients with mesial temporal lobe epilepsy (mTLE), cryptogenic TLE (cTLE), who show no abnormalities in high-resolution MRI, and healthy controls using single voxel (1)H MRS at 3 T. Twelve patients with mTLE, nine with cTLE and 22 controls were investigated using a short echo time STEAM protocol. Voxels were positioned bilaterally in the medial and lateral temporal lobes. Spectra were processed with LCModel. Significantly lower mean NAA were detected in mTLE patients (P < 0.001) and a trend towards lower NAA in cTLE patients compared to controls (P = 0.053). Glx was not different between groups. Estimates of Glu showed a different metabolic pattern in mTLE with elevated Glu in lateral compared with medial voxels on the ipsilateral side to seizure onset (P = 0.019). MI concentrations were significantly lower in cTLE (P < 0.001) and in mTLE patients (P = 0.005) compared with healthy controls. MI/Cre was significantly reduced in cTLE patients only (P = 0.004). The results confirm low NAA in mTLE and to a lesser extent in cTLE patients. MI and mI/Cre were identified as potential metabolic indicators of the epileptogenic area in cTLE.
authors.affiliation: Universitätsklinik für Neurologie, Abteilung für Klinische Epilepsieforschung, Medizinische Universität Wien, A-1090 Vienna, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Riederer
authors.forename: Michal
authors.initials: M
authors.lastname: Bittsanský
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt
authors.forename: Vladimír
authors.initials: V
authors.lastname: Mlynárik
authors.forename: Christoph
authors.initials: C
authors.lastname: Baumgartner
authors.forename: Ewald
authors.initials: E
authors.lastname: Moser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Serles
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000737:chemistry / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism / Q000473:pathology; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged
chemical_list: D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline