title: Quantitative evaluation of genetic and environmental parameters determining antibody response induced by vaccination against bovine respiratory syncytial virus.
abstract: The parameters controlling IgG antibody responses induced by vaccination against bovine respiratory syncytial virus (BRSV) were investigated in 463 Holstein-Charolais crossbred cattle. Pre- and post-vaccination sera were tested by enzyme linked immunosorbent assays (ELISA) for BRSV-specific IgG and IgG2. Year-of-birth, age, sex and pre-existing antibody were significant sources of variation for IgG responses. Pre-vaccination, progeny with a higher proportion of Holstein genes had higher total BRSV-IgG. By Day 35 post-vaccination, heritabilities peaked at 0.26 for total BRSV-IgG and 0.36 for BRSV-IgG1. There was no evidence for interbreed differences between Holstein and Charolais calves, post-vaccination. These results suggest that calf-sire has a major heritable influence on serum IgG levels following BRSV immunisation.
authors.affiliation: University of Glasgow Veterinary School, Glasgow G61 1QH, UK. ronan.oneill@agriculture.gov.ie
authors.forename: R G
authors.initials: RG
authors.lastname: O'Neill
authors.forename: J A
authors.initials: JA
authors.lastname: Woolliams
authors.forename: E J
authors.initials: EJ
authors.lastname: Glass
authors.forename: J L
authors.initials: JL
authors.lastname: Williams
authors.forename: J L
authors.initials: JL
authors.lastname: Fitzpatrick
mesh_terms: D000375:Aging; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002417:Cattle / Q000235:genetics / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006824:Hybridization, Genetic; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D022261:Respiratory Syncytial Virus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D018112:Respiratory Syncytial Virus, Bovine / Q000276:immunology*; D012727:Sex Characteristics
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D022261:Respiratory Syncytial Virus Vaccines