title: [Urogenital abnormalities and atresia of the gastrointestinal tract].
abstract: BACKGROUND
  The goal of the study was to ivestigate the frequency of urogenital congenital abnormalities among atresias of the digestive system and analyze fetal maldevelopment. The study also deals with gastrointestinal and urogenital embryology.
  
  
  METHODS
  This retrospektive study analyzed the clinical status of 55 newborns admitted to the Pediatric Surgery Clinic in Novi Sad due to atresia of the gastrointestinal tract during 1995-2003. All atresias were classified at primordial gut levels (foregut, midgut and hindgut). The incidence of associated abnormalities, especially urogenital, was analyzed. Diagnostic procedures included standard methods: clinical investigation, ultrasound, native and contrast medium radiography, etc.
  
  
  RESULTS
  Results showed that urogenital anomalies were present in 21 (38.18%) newborns with gastrointestinal atresia. Foregut atresia was diagnosed in 14 newborns and it was associated with urogenital congenital anomalies in 9 (64.28%) newborns. Midgut atresias were found in 15 patients and in 4 (22.22/%) they were associated with urogenital anomalies. Hindgut atresias were established in 23 and in 8 (34. 78%) cases they were associated with urogenital anomalies.
  
  
  CONCLUSIONS
  It was confirmed that foregut atresias ara commonly accompanied by associated abnormalities. That is why the fourth gestational week is important when both gastrointestinal and urogenital systems are developed. When midgut differentiates into its own derivates, the frequency of congenital anomalies decreases for a short period, and then increases again during foregut development (seventh and eighth gestational weeks). There were no information on environmental teratogenic factors in maternal history. These abnormalities may be explained by complex urorectal development and separation of two systems.
authors.affiliation: Institut za zdravstvenu zastitu dece i omladine, Novi Sad Klinika za decju hirurgiju.
authors.forename: Duganka
authors.initials: D
authors.lastname: Dobanovacki
authors.forename: Smiljana
authors.initials: S
authors.lastname: Marinković
authors.forename: Radoica
authors.initials: R
authors.lastname: Jokić
authors.forename: Dragana
authors.initials: D
authors.lastname: Zivković
authors.forename: Danica
authors.initials: D
authors.lastname: Stanić-Canji
authors.forename: Vladimir
authors.initials: V
authors.lastname: Borisev
mesh_terms: D000015:Abnormalities, Multiple; D004933:Esophageal Atresia / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000150:complications*; D008297:Male; D014564:Urogenital Abnormalities / Q000150:complications*