title: Gastroesophageal reflux and laryngeal cancer: causation or association? A critical review.
abstract: Gastroesophageal reflux disease has been implicated as a causative factor in several laryngeal disorders. Its involvement in laryngeal cancer is of interest not only from a clinicopathologic aspect, but also from a public health perspective. However, despite a number of studies, a causal relationship with laryngeal cancer is uncertain. In this article, we address the current literature in a critical manner to facilitate the understanding of this subject and evaluate the relationship between gastroesophageal reflux disease and laryngeal carcinoma.
authors.affiliation: Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Qadeer
authors.forename: Natalie
authors.initials: N
authors.lastname: Colabianchi
authors.forename: Marshall
authors.initials: M
authors.lastname: Strome
authors.forename: Michael F
authors.initials: MF
authors.lastname: Vaezi
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects