Possible insensitivity of the polybrene antibody screen to detect anti-Jka.
An acute hemolytic transfusion reaction (AHTR) occurred in a 28-yr-old gravida immediately after transfusion with leukocyte-reduced red cells. The patient gave no history of prior transfusion. Initial serologic testing by the polybrene method was negative for both antibody screening and cross-matching. Further testing by the indirect anti-globulin test (IAT) demonstrated the presence of anti-Jka antibodies. These observations suggest a limitation in polybrene testing for Jka antibodies associated with hemolytic transfusions. Caution is advised when the polybrene test is used as the sole determinant for anti-Jka.
Liu
Fuping
F
M.S., Blood Group Reference Laboratory, Dongguan Blood Center, Humen Town, Dongguan, Guangdong 523930, P.R. China.
Liu
Jingchun
J
D000208:Acute Disease; D000328:Adult; D001787:Blood Group Incompatibility / Q000175:diagnosis*; D001788:Blood Grouping and Crossmatching; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006461:Hemolysis; D006583:Hexadimethrine Bromide; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D007667:Kidd Blood-Group System / Q000276:immunology*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000601:surgery*
D007518:Isoantibodies; D007667:Kidd Blood-Group System; D006583:Hexadimethrine Bromide