title: Over-expression of p53 protein in esophageal squamous cell carcinoma of women.
abstract: OBJECTIVE
  Most physicians naturally accept the etiological aspect that the incidence of esophageal squamous cell carcinoma (ESCC) is excessively more frequent in men than that in women. However, a definitely scientific confirmation to explain it has not been found. In the current study, we investigated the relationship between gender and p53 over-expression, which might resolve the difference between the genders in the mechanism for carcinogenesis in ESCC.
  
  
  METHODS
  Immunohistochemical expression of p53 was examined for 134 ESCCs, and the correlation of the gender with the clinicopathologic features and over-expression of p53 was compared.
  
  
  RESULTS
  The proportion of p53 over-expression in women was 23.8% (5 out of 21) and this incidence proportion was significantly lower than that in men (48.7%, 55 out of 113; p=0.031).
  
  
  CONCLUSIONS
  This biological modulation might be correlated with the lower incidence of ESCC in women.
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, Koga, Japan. ntvb@med.uoeh-u.ac.jp
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Nozoe
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53