title: Low HDL-cholesterol, hypertension and impaired glucose tolerance as predictors of acute myocardial infarction in northern area of Japan.
abstract: Acute myocardial infarction (AMI) has gradually been increasing in Japan; however, since the burden of Japanese residents for risk factors (RFs) of AMI, such as hypercholesterolemia, is chronologically less accumulated compared with American and European people, their RFs of AMI may be different from those in western countries. To answer this question, a retrospective community-based study was carried out enrolling 722 first time AMI patients in Hokkaido, the northern island of Japan. As controls, 1748 age-, sex- and residence-matched subjects were randomly chosen from a data-base of a health check-up organization. We assessed associations between premorbid variables and the RFs for AMI. In men, the most important predictor reflected by high odds ratio (OR) was low HDL-cholesterol (HDL-C). Hypertension (HT) and impaired glucose tolerance (IGT) were also independent RFs. In women, HT represented the highest OR, and low HDL-C, high triglyceride (TG) and IGT followed. Total cholesterol (TC) was a negative predictor for AMI in both sexes, because mean TC level of AMI patients was less than that of controls probably because of acute phase reaction. Thus, low HDL-C, HT, IGT and high TG, which represent the state of metabolic syndrome, were important predictors of AMI. And it was suggested that low HDL-C plays a pivotal role in a population whose TC level is not high.
authors.affiliation: Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Oyama
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sakuma
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kishimoto
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Saijo
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Sakai
authors.forename: Kazushi
authors.initials: K
authors.lastname: Urasawa
authors.forename: Akira
authors.initials: A
authors.lastname: Kitabatake
authors.forename: Reiko
authors.initials: R
authors.lastname: Kishi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsui
mesh_terms: D000367:Age Factors; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007564:Japan; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides