Kidney failure and the gut: p-cresol and the dangers from within.
Previously, uremic toxins were sometimes regarded as a large, mysterious, but also anonymous group of factors potentially contributing to morbidity and mortality in end-stage renal disease. By identifying the protein-bound solute p-cresol as a risk factor for mortality in dialysis patients, Bammens and colleagues for the first time present evidence of a clinically relevant uremic toxin in relation to clinical outcome.
Ketteler
M
M
Department of Nephrology, University Hospital of the Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany. mketteler@ukaachen.de
D003106:Colon / Q000378:metabolism* / Q000503:physiopathology; D003408:Cresols / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000401:mortality / Q000503:physiopathology; D011237:Predictive Value of Tests; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood* / Q000401:mortality* / Q000503:physiopathology; D012307:Risk Factors; D014118:Toxins, Biological / Q000097:blood
D003408:Cresols; D014118:Toxins, Biological; C032538:4-cresol