title: Neurodevelopmental outcome in children with intraventricular hemorrhage.
abstract: To clarify the neurodevelopmental outcome in children with intraventricular hemorrhage, a follow-up study was performed for a consecutive group of 335 subjects in one tertiary center born between 1981 and 1999. Their mean gestation and birth weight were 28.1 weeks and 1162.2 gm, respectively. The follow-up period ranged from 3 to 20 years (mean: 7.5 years). The neurodevelopmental outcomes were normal in 188 (56.1%), cerebral palsy in 75 (22.4%), mental retardation in 34 (10.2%), and borderline intelligence in 38 (11.3%). There were statistically significant differences in the outcomes among the groups with different grades of intraventricular hemorrhage. Approximately 70% of the children with intraventricular hemorrhage grade 1 were normal, whereas only 15.4% of the children with intraventricular hemorrhage grade 4 were normal. Cerebral palsy was associated with as high as 71.2% in the patients with intraventricular hemorrhage grade 4. The overall incidence of epilepsy was 39/335 (11.6%). This study has not demonstrated clear improvement of the outcome in children with intraventricular hemorrhage between the 1980s and 1990s.
authors.affiliation: Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan. jqfkk025@yahoo.co.jp
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Futagi
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Toribe
authors.forename: Kana
authors.initials: K
authors.lastname: Ogawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000293:Adolescent; D000328:Adult; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D002547:Cerebral Palsy / Q000175:diagnosis / Q000209:etiology; D002552:Cerebral Ventricles; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000175:diagnosis / Q000209:etiology; D007360:Intelligence; D007564:Japan; D009460:Neurologic Examination; D017063:Outcome Assessment, Health Care; D011379:Prognosis