title: Azetidine-2-carboxylic acid in garden beets (Beta vulgaris).
abstract: Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid. In many species, including man, L-Aze is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding. In animal models of teratogenesis, it causes a wide range of malformations. The role of L-Aze in human disease has been unexplored, probably because the compound has not been associated with foods consumed by humans. Herein we report the presence of L-Aze in the garden or table beet (Beta vulgaris).
authors.affiliation: School of Medicine, Stanford University, CA 94305, USA. gim@med.stanford.edu
authors.forename: Edward
authors.initials: E
authors.lastname: Rubenstein
authors.forename: Haihong
authors.initials: H
authors.lastname: Zhou
authors.forename: Karolina M
authors.initials: KM
authors.lastname: Krasinska
authors.forename: Allis
authors.initials: A
authors.lastname: Chien
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Becker
mesh_terms: D001383:Azetidinecarboxylic Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D027461:Beta vulgaris / Q000737:chemistry*; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D015394:Molecular Structure; D035281:Plant Tubers / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives; D013723:Teratogens / Q000737:chemistry
chemical_list: D013723:Teratogens; D001383:Azetidinecarboxylic Acid; D011392:Proline