Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14).
We report a case of leukemic mantle cell lymphoma of the blastoid variant with complex chromosomal rearrangements leading to the recombination of BCL1 from 11q13 and IGH from 14q32. G-banding analysis showed, in addition to multiple other chromosome abnormalities, a del(11)(q13) and addition of unknown material to chromosome arms 13p and 21p. The two latter rearrangements were revealed, by use of multicolor in situ hybridization (M-FISH) analysis, to be a der(13)(qter-->p11::14q32::11q13-->11q22::14q32-->14q11::11q22-->11qter) and a similar der(21)(qter-->p11::14q32::11q13-->11q23::14q32-->14q11::11q22-->11qter). FISH with locus-specific probes for BCL1 and IGH showed a fusion signal on both derivative chromosomes.
Aamot
Hege Vangstein
HV
Department of Cancer Genetics, The Norwegian Radium Hospital, N-0310 Oslo, Norway.
Tjønnfjord
Geir E
GE
Delabie
Jan
J
Heim
Sverre
S
D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic