Synthesis of a potent 5'-methylthioadenosine/S-adenosylhomocysteine (MTAN) inhibitor.
MTAN has been known to occur in a variety of bacterial cell types. Due to the evolution of bacterial strains which are resistant to some of the most powerful antibiotics there has been a renewed interest in the development of novel anti-microbial agents. Presented herein is a synthesis of a potent MTAN inhibitor, namely 2-amino-4-[5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-ylmethylsulfanyl]-butyric acid (1).
Kamath
Vivekanand P
VP
BioCryst Pharmaceuticals Inc., 2190 Parkway Lake Drive, Birmingham, AL 35244, USA.
Zhang
Jainwen
J
Morris
Philip E
PE
Babu
Y Sudhakar
YS
D002087:Butyrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D003839:Deoxyadenosines / Q000037:antagonists & inhibitors*; D012435:S-Adenosylhomocysteine / Q000037:antagonists & inhibitors*; D013056:Spectrophotometry, Ultraviolet; D013872:Thionucleosides / Q000037:antagonists & inhibitors*
C512306:2-amino-4-(5-(4-amino-5H-pyrrolo(3,2-d)pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-ylmethylsulfanyl)butyric acid; D002087:Butyrates; D003839:Deoxyadenosines; D013872:Thionucleosides; C008500:5'-methylthioadenosine; D012435:S-Adenosylhomocysteine