[Correlation of obesity with C-reactive protein, leptin and insulin sensitive index in children].
OBJECTIVE
To study the correlation between obesity and hypersensitive C-reactive protein (hsCRP), leptin, and insulin sensitive index (ISI) in children.


METHODS
The subjects included 69 obese volunteers and 30 age and gender-matched normal volunteers who were recruited from 13702 children aged 2 to 18 years in Xiangtan City by sampling survey. The body mass index (BMI), hsCRP, leptin, fasting plasma glucose (FPG), and fasting insulin (INS) were tested, and then the ISI was calculated. The results between the obese and normal children were compared. The correlation between the parameters was evaluated.


RESULTS
The values of hsCRP, leptin and INS in obese children were significantly higher than those in the normal controls (P < 0.01), but the ISI in obese children was significantly lower than that in normal controls (P < 0.01). The BMI was significantly positively correlated with the values of hsCRP, leptin and INS (r=0.225, P < 0.05; r=0.776, P < 0.01; r=0.568, P < 0.01), but was significantly negatively correlated with the ISI (r=-0.889, P < 0.01). There was a positive correlation between the value of hsCRP and the values of FPG and INS (r=0.429, P < 0.01; r=0.206, P < 0.05), and there was a negative correlation between the value of hsCRP and the ISI (r=-0.889, P < 0.01). The value of leptin significantly positively correlated with the values of INS and BMI, and significantly negatively correlated with the ISI.


CONCLUSIONS
Insulin resistance and leptin resistance exist in obese children. The inflammatory factors such as CRP and leptin may be involved in the pathogenesis of obesity.
Xiao
Yun-Wu
YW
Department of Medicine, Medical School of Xiangtan Vocational and Technical College, Xiangtan, Hunan 411100, China. xiaoyunwu2005@tom.com
Huang
Xue-Mei
XM
Deng
Ying-Xia
YX
Long
Hui
H
Cheng
Fang-Qun
FQ
Jian
Hui
H
Long
Guo-Wen
GW
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D016328:NF-kappa B / Q000502:physiology; D009765:Obesity / Q000097:blood*
D001786:Blood Glucose; D020738:Leptin; D016328:NF-kappa B; D002097:C-Reactive Protein