title: Dose response to cerebrospinal fluid drainage on cerebral perfusion in traumatic brain-injured adults.
abstract: OBJECTIVE
  Intracranial hypertension remains a common complication of traumatic brain injury (TBI). Ventriculostomy drainage is a recommended therapy to decrease intracranial pressure (ICP), but little empirical evidence exists to guide treatment. The authors conducted a study to examine systematically the effect of cerebral spinal fluid (CSF) drainage on ICP and indices of cerebral perfusion.
  
  
  METHODS
  Intracranial pressure, cerebral perfusion pressure (CPP), cerebral blood flow velocity (CBFV), and near-infrared spectroscopy-determined regional cerebral oxygenation (rSO2) were measured in 58 patients (with Glasgow Coma Scale scores < or = 8) before, during, and after ventriculostomy drainage. Three randomly ordered CSF drainage protocols varied in the volume of CSF removed (1 ml, 2 ml, and 3 ml). Physiological variables were time averaged in 1-minute blocks from baseline to 10 minutes after cessation of ventricular drainage. There was a significant dose-time interaction for ICP with the three-extraction volume protocol, with incremental decreases in ICP (F [20, 1055] = 6.10; p = 0.0001). There was a significant difference in the CPP depending on the amount of CSF removed (F [2, 1787] = 3.22; p = 0.040) and across time (F [10, 9.58] = 11.9; p = 0.0003) without a significant dose-time interaction. A 3-ml withdrawal of CSF resulted in a 10.1% decrease in ICP and a 2.2% increase in CPP, which were sustained for 10 minutes. There was no significant dose, time or dose-time interaction with CBFV or rSO2.
  
  
  CONCLUSIONS
  Cerebrospinal fluid drainage (3 ml) significantly reduced ICP and increased CPP for at least 10 minutes. Analysis of these findings supports the use of ventriculostomy drainage as a means of at least temporarily reducing elevated ICP in patients with TBI.
authors.affiliation: University of Pittsburgh School of Nursing, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA. mek1@pitt.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Kerr
authors.forename: B B
authors.initials: BB
authors.lastname: Weber
authors.forename: S M
authors.initials: SM
authors.lastname: Sereika
authors.forename: J
authors.initials: J
authors.lastname: Wilberger
authors.forename: D W
authors.initials: DW
authors.lastname: Marion
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000134:cerebrospinal fluid* / Q000628:therapy*; D002557:Cerebrospinal Fluid Shunts; D004322:Drainage; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D013997:Time Factors