[The role of hormonal homeostasis in pathogenesis of endothelial dysfunction during preeclampsia].
The aim of the study was the establishment of correlations between hormone homeostasis and metabolism of NO during preeclampsia. Blood of pregnant women with gestation age 30-32 weeks was investigated by EPR (electron paramagnetic resonance) and enzyme immunoassay methods. It was shown that during preeclampsia progesterone content decreased by 32% and estradiol content decreased by 37%, while testosterone content increased by 51% in comparison with those levels in women with physiological pregnancy. During preeclampsia concentration of free NO reduces by 32%, the content of high HbNO complexes is revealed. It is observed the decrease of oxygen partial pressure (pO(2)) during preeclampsia. Disorders of hormone homeostasis plays important role in the pathogenesis of endothelial dysfunction during preeclampsia. On the basis of obtained results we may conclude that decrease of vasodilatatory hormones (progesterone and estradiol) content and hypoxia-induced deposition of free NO in hemoglobin promotes increasing of vascular reactivity and development of hypertension.
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D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D009569:Nitric Oxide / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011379:Prognosis; D013739:Testosterone / Q000097:blood*; D014664:Vasodilation / Q000502:physiology
D015415:Biomarkers; D009569:Nitric Oxide; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol