The impact of bioactive molecules to stimulate tooth repair and regeneration as part of restorative dentistry.
After implantation in the exposed pulp, some molecules of the den-tin extracellular matrix induce the formation of a reparative dentinal bridge in the coronal pulp. In some cases, total occlusion of the root canal also is observed. This is the case for bone sialoprotein, bone morphogenetic protein-7, Dentonin (a fragment from matrix extracellular phosphoglycoprotein), and two small amelogenin gene splice products (A+4 and A-4). Cells implicated in the reparative process are recruited, proliferate, and differentiate into osteoblast-like and odontoblast-like cells. The same results may be obtained by direct implantation of odontoblast progenitor cell into the pulp.
Goldberg
Michel
M
Laboratoire de Réparation et Remodelage des Tissus Oro-Faciaux, Groupe Matrices Extracellulaires et Biomineralisations, Faculté de Chirurgie Dentaire, Université René Descartes, Montrouge, France. mgoldod@aol.com
Lacerda-Pinheiro
Sally
S
Jegat
Nadege
N
Six
Ngampis
N
Septier
Dominique
D
Priam
Fabienne
F
Bonnefoix
Mireille
M
Tompkins
Kevin
K
Chardin
Hélène
H
Denbesten
Pamela
P
Veis
Arthur
A
Poliard
Anne
A
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism / Q000627:therapeutic use*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003785:Dental Pulp Capping / Q000379:methods*; D003793:Dental Restoration, Permanent / Q000379:methods*; D003804:Dentin / Q000166:cytology / Q000378:metabolism* / Q000601:surgery; D016326:Extracellular Matrix Proteins / Q000378:metabolism / Q000627:therapeutic use*; D006023:Glycoproteins / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D058574:Integrin-Binding Sialoprotein; D010750:Phosphoproteins / Q000378:metabolism / Q000627:therapeutic use; D051381:Rats; D012795:Sialoglycoproteins / Q000378:metabolism / Q000627:therapeutic use
D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; C546871:IBSP protein, human; D058574:Integrin-Binding Sialoprotein; C486579:MEPE protein, human; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D002126:Calcium Hydroxide