title: Theoretical analysis of single-molecule force spectroscopy experiments: heterogeneity of chemical bonds.
abstract: We show that the standard theoretical framework in single-molecule force spectroscopy has to be extended to consistently describe the experimental findings. The basic amendment is to take into account heterogeneity of the chemical bonds via random variations of the force-dependent dissociation rates. This results in a very good agreement between theory and rupture data from several different experiments.
authors.affiliation: Theoretische Physik, and Experimentelle Biophysik, Universität Bielefeld, Bielefeld, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Raible
authors.forename: M
authors.initials: M
authors.lastname: Evstigneev
authors.forename: F W
authors.initials: FW
authors.lastname: Bartels
authors.forename: R
authors.initials: R
authors.lastname: Eckel
authors.forename: M
authors.initials: M
authors.lastname: Nguyen-Duong
authors.forename: R
authors.initials: R
authors.lastname: Merkel
authors.forename: R
authors.initials: R
authors.lastname: Ros
authors.forename: D
authors.initials: D
authors.lastname: Anselmetti
authors.forename: P
authors.initials: P
authors.lastname: Reimann
mesh_terms: D001696:Biomechanical Phenomena / Q000379:methods; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D016008:Statistical Distributions; D013816:Thermodynamics