An emerging severe leukoencephalopathy: is it due to HIV disease or highly active antiretroviral therapy?
We report an individual who had HIV-associated dementia, but a good clinical response to antiretroviral therapy, with a rising CD4 count and undetectable viral load. A severe leukoencephalopathy was noted at postmortem; however, no HIV immunopositive cells were found in the brain, suggesting that this new severe leukoencephalopathy is associated with immune reconstitution.
Rackstraw
Simon
S
GU/HIV Medicine, Andrewes Unit, King George V Building, St Bartholomew's Hospital, West Smithfield, London, UK. Simon.Rackstraw@bartsandthelondon.nhs.uk
Meadway
Jeanette
J
Bingham
James
J
Al-Sarraj
Safa
S
Everall
Ian
I
D015526:AIDS Dementia Complex / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015658:HIV Infections / Q000150:complications* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged