Pemphigoid-like ocular lesions in patients with graft-versus-host disease following allogeneic bone marrow transplantation.
We present two patients who developed keratitis sicca and pemphigoid-like symptoms following allogeneic bone marrow transplantation (BMT). The diagnosis of ocular graft-versus-host disease (GvHD) was considerably delayed in both. They were admitted to the reference ophthalmology and posttransplant care departments years after allogeneic BMT, when skin biopsy revealed changes typical for chronic GvHD. In both cases either systemic or local immunosuppressive treatment led to improvement of the clinical condition but did not significantly change patients' quality of life.
Karwacka
E
E
Department of Ophthalmologic Disorders, Warsaw Medical University, ul. Lindleya 4, 02-006 Warsaw, Poland.
Ołdakowska-Jedynak
U
U
Brydak-Godowska
J
J
Paczek
L
L
Kecik
D
D
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D010391:Pemphigoid, Bullous / Q000209:etiology*; D012867:Skin / Q000473:pathology; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D007166:Immunosuppressive Agents