title: Solid-phase staudinger ligation from a novel core-shell-type resin: a tool for facile condensation of small peptide fragments.
abstract: [reaction: see text] Solid-phase Staudinger ligation of small peptides was performed on a novel core-shell-type resin. Solid-phase Staudinger ligation was mediated by synthetic solid-supported phosphinothiol, which was readily prepared by a straightforward synthetic route. This protocol afforded final peptide products in excellent yields and purities and thus could provide the opportunity to facilitate a simple manipulation for condensation of peptide fragments. In particular, the resulting resin could be recycled in a successful manner.
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Kwanak-Gu, Shilim-Dong, San 56-1, Seoul 151-742, Korea.
authors.forename: Hanyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Jin Ku
authors.initials: JK
authors.lastname: Cho
authors.forename: Saburo
authors.initials: S
authors.lastname: Aimoto
authors.forename: Yoon-Sik
authors.initials: YS
authors.lastname: Lee
mesh_terms: D015394:Molecular Structure; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*
chemical_list: D009946:Organothiophosphorus Compounds; D010446:Peptide Fragments; D010455:Peptides; D012117:Resins, Synthetic