title: Hepatitis C treatment for people with severe mental illness.
abstract: Over 4 million people in the United States are chronically infected with hepatitis C virus (HCV), and, if untreated, over 20% of these will progress to more serious disease. Persons with severe mental illness (SMI) have markedly elevated rates of HCV infection, but treatment of persons with SMI and HCV has been controversial. Effective antiviral treatment is available, but side effects include depression and other neuropsychiatric symptoms. This article reviews the available data on neuropsychiatric side effects of interferon (IFN) treatment, discusses the limitations of the current research, and makes recommendations regarding HCV treatment in persons with SMI.
authors.affiliation: Dartmouth Medical School, Hanover NH, USA. Lisa.A.Mistler@dartmouth.edu
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Mistler
authors.forename: Mary F
authors.initials: MF
authors.lastname: Brunette
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Marsh
authors.forename: Robert M
authors.initials: RM
authors.lastname: Vidaver
authors.forename: Ravi
authors.initials: R
authors.lastname: Luckoor
authors.forename: Stanley D
authors.initials: SD
authors.lastname: Rosenberg
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D003865:Major Depressive Disorder / Q000139:chemically induced* / Q000453:epidemiology*; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D007372:Interferons / Q000009:adverse effects*; D001523:Mental Disorders / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents; D007372:Interferons