title: Acute sensorineural hearing loss and vertigo in a young adult with congenital plasminogen disorder.
abstract: A 19-year-old Japanese man exhibiting acute right sensorineural hearing loss and vertigo was referred to the Jichi Medical School Hospital in June 1994. Although he had no history of recurrent thrombosis and no family history of thrombosis, he had undergone reconstruction of a right foot joint fracture 4 months earlier. Screening studies for plasminogen activity demonstrated 10% of normal plasminogen activity and his plasminogen was diagnosed as "plasminogen Tochigi" by the gene analysis using restriction enzyme Fnu4HI. The patient's hearing returned to normal with administration of heparin, and he was prescribed warfarin for the prevention of thrombosis until October 1995. There was no recurrence of hearing loss during seven years of follow-up. The cause of this patient's hearing loss is believed to be associated with consumption of the already low levels of plasminogen as a result of his surgery as well as congenital plasminogen disorder.
authors.affiliation: Department of Otorhinolaryngology, International University of Health and Welfare Hospital, 537-3 Iguchi, Nishinasuno-machi, Nasu-gun, 329-2763, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Ken
authors.initials: K
authors.lastname: Kitamura
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Tanaka
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ichimura
authors.forename: Jun
authors.initials: J
authors.lastname: Mimuro
authors.forename: Seiji
authors.initials: S
authors.lastname: Madoiwa
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sakata
mesh_terms: D000208:Acute Disease; D000328:Adult; D001301:Audiometry, Pure-Tone; D004262:DNA Restriction Enzymes / Q000235:genetics; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006319:Hearing Loss, Sensorineural / Q000150:complications* / Q000175:diagnosis; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010958:Plasminogen / Q000172:deficiency* / Q000235:genetics*; D012008:Recurrence; D012720:Severity of Illness Index; D013927:Thrombosis / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D014717:Vertigo / Q000150:complications*
chemical_list: C043704:Tochigi II plasminogen; D010958:Plasminogen; D006493:Heparin; D004262:DNA Restriction Enzymes