Remission with ursodeoxycholic acid of type 1 autoimmune hepatitis resistant to azathioprine and steroids.
Combination therapy with steroids and azathioprine is the reference treatment for autoimmune hepatitis, but potential adverse effects are numerous and intolerance can occur. We report a patient with a well-documented type 1 autoimmune hepatitis intolerant to corticosteroids and azathioprine therapy, in whom eight years of ursodeoxycholic acid monotherapy was associated with biochemical and histological remission.
Duclos-Vallée
Jean-Charles
JC
Centre Hépato-Biliaire and UPRES 3541, Hôpital Paul Brousse, Villejuif. jean-charles.duclos-vallee@pbr.ap-hop-paris.fr
Di Martino
Vincent
V
Cazier
Alain
A
Ballot
Eric
E
Johanet
Catherine
C
Yamamoto
Ana Maria
AM
Emile
Jean-François
JF
Guettier
Catherine
C
Coutarel
Pierre
P
Cadranel
Jean-François
JF
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D019693:Hepatitis, Autoimmune / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D002756:Cholagogues and Choleretics; D007166:Immunosuppressive Agents; D014580:Ursodeoxycholic Acid; D001379:Azathioprine