Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study.
Penile erectile tissue is a highly vascularised smooth muscle which hitherto has been an unexplored target for the neuromodulatory effect of hydrogen sulphide. In this study, intracavernous injection of sodium hydrogen sulphide to primates resulted in significant increases in penile length and cavernous pressure. In another set of experiments, administration of DL-propargylglycine (inhibitor of cystathionine gamma-lyase) to rats resulted in significant reduction in cavernous nerve stimulation-evoked perfusion pressure. Our pilot experiment suggests a possible role for endogenous hydrogen sulphide in erectile physiopharmacology through facilitation of nerve-mediated penile tumescence; this is confirmed by the inhibitory effect of propargylglycine on the proerectile pathway.
Srilatha
Balasubramanian
B
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Adaikan
P Ganesan
PG
Moore
Philip K
PK
D000480:Alkynes / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D003542:Cystathionine gamma-Lyase / Q000037:antagonists & inhibitors; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000882:Haplorhini; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D010215:Papio; D010410:Penile Erection / Q000187:drug effects* / Q000502:physiology; D010413:Penis / Q000098:blood supply / Q000187:drug effects / Q000294:innervation; D010865:Pilot Projects; D011312:Pressure; D051381:Rats; D013997:Time Factors
D000480:Alkynes; D004791:Enzyme Inhibitors; C009055:propargylglycine; D003542:Cystathionine gamma-Lyase; D005998:Glycine; D006862:Hydrogen Sulfide