title: A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland.
abstract: The aim of this study was to characterize the familial nature of cutaneous malignant melanoma (CMM) in Iceland. Risk ratio was used to estimate the risk among relatives of all CMM index cases diagnosed in Iceland over a 45-year period (1955-1999), using data from the National Cancer Registry and a genealogy database that covers the whole of Iceland's population. First-, second-, and third-degree relatives of CMM patients did not have an increased risk of the disease, and no added risk of other types of cancer among relatives was observed, except for thyroid cancer in first-degree male relatives. Seven individuals were diagnosed with two or more primary CMM in this period; none of these individuals had a first or second-degree relative with CMM. Altogether, 2.4% of cases were familial, as defined by commonly used criteria. In conclusion, high-penetrance susceptibility genes do not contribute much to CMM in the Icelandic population. The great majority of CMM cases in Iceland are most likely caused by the interplay between environmental causes and low-risk genes.
authors.affiliation: Iceland Genomics Corporation, Snorrabraut 60, 105 Reykjavik, Iceland.
authors.forename: Bjarki Jonsson
authors.initials: BJ
authors.lastname: Eldon
authors.forename: Steinunn
authors.initials: S
authors.lastname: Thorlacius
authors.forename: Thorvaldur
authors.initials: T
authors.lastname: Jonsson
authors.forename: Jon Gunnlaugur
authors.initials: JG
authors.lastname: Jonasson
authors.forename: Jens
authors.initials: J
authors.lastname: Kjartansson
authors.forename: Sigurdur
authors.initials: S
authors.lastname: Bodvarsson
authors.forename: Eirikur
authors.initials: E
authors.lastname: Steingrimsson
authors.forename: Thorunn
authors.initials: T
authors.lastname: Rafnar
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D018570:Risk Assessment; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000235:genetics*