[Incidence of multiple (second) primary tumors of head and neck following tobacco smoking].
A review presents an incidence of multiple (second) primary tumors of head and neck region resulted from an exposure to tobacco smoke and ethanol. Further, epidemiology, clinical implications, molecular alterations and an impact of genetic factor are described. Finally, alternative theories of origin of multiple primary tumors are discussed.
Szyfter
Krzysztof
K
Instytut Genetyki Człowieka PAN, Poznań. szyfkris@man.poznan.pl
Wierzbick
Małgorzata
M
Giefing
Maciej
M
Rydzanicz
Małgorzata
M
D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology; D011044:Poland / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology*