title: Recovery after a traumatic brain injury depends on diurnal variations effect of cystatin C.
abstract: Many studies indicate that the hour of the day at which the onset of stroke occurs is very important in patient recovery. Furthermore, multiple studies have been conducted which show that ischemia in rats produces different magnitudes of injury depending on the hour of the day at which it was induced. Using a traumatic brain injury (TBI) model, we analyzed the effect of the time of day on the recovery of rats and obtained a higher survival rate if TBI was induced at 01:00 h as compared with TBI induced at 13:00 h. We also analyzed the effect of the protease inhibitor cystatin C (CC) on the recovery of rats from TBI and found that it increased mortality and bleeding, and that these effects were more pronounced at 13:00 h.
authors.affiliation: Departamento de Fisiologia, Facultad de Medicina, UNAM. Apdo. Postal 70-250, Mexico, D.F. 04510, Mexico.
authors.forename: Marina
authors.initials: M
authors.lastname: Martinez-Vargas
authors.forename: Ruben
authors.initials: R
authors.lastname: Gonzalez-Rivera
authors.forename: Maribel
authors.initials: M
authors.lastname: Soto-Nuñez
authors.forename: Marina
authors.initials: M
authors.lastname: Cisneros-Martinez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Huerta-Saquero
authors.forename: Julio
authors.initials: J
authors.lastname: Morales-Gomez
authors.forename: Juan
authors.initials: J
authors.lastname: Molina-Guarneros
authors.forename: Luz
authors.initials: L
authors.lastname: Navarro
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D002940:Circadian Rhythm; D055316:Cystatin C; D015891:Cystatins / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects*; D015599:Trauma Severity Indices
chemical_list: C525032:Cst3 protein, rat; D055316:Cystatin C; D015891:Cystatins; D018696:Neuroprotective Agents