Cross-talk between F3/contactin and Notch at axoglial interface: a role in oligodendrocyte development.
Increasing evidence has shown that the Notch signalling pathway regulates oligodendrogliogenesis. Upon binding to classical Delta/Serrate/Lag-2 ligands, Notch signalling promotes generation of oligodendrocyte precursor cells while inhibiting their further differentiation into myelinating oligodendrocytes. In our recent studies, we have found that two neural cell adhesion molecules, F3/contactin and NB-3 interact with Notch receptors and promote oligodendrocyte development. Remarkably, all these F3 and NB-3/Notch cascade-related events required Deltex1 as the intermediate element. Experiments using several animal models further imply the function of F3/Notch signalling in vivo, which designates Notch signalling as a ligand-dependent, multipotential cascade involved in oligodendrocyte development.
Hu
Qi-Dong
QD
Institute of Molecular and Cell Biology, Singapore General Hospital, Singapore, Singapore, and Department of Pharmacology and Human Physiology, University of Bari, Italy.
Ma
Quan-Hong
QH
Gennarini
Gianfranco
G
Xiao
Zhi-Cheng
ZC
D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D058966:Contactins; D006801:Humans; D023421:Models, Animal; D009186:Myelin Sheath / Q000378:metabolism / Q000648:ultrastructure; D009836:Oligodendroglia / Q000166:cytology / Q000378:metabolism*; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
C111104:CNTN6 protein, human; D002352:Carrier Proteins; D015816:Cell Adhesion Molecules, Neuronal; D058966:Contactins; D051880:Receptors, Notch; C409218:deltex protein, vertebrate