Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects.
There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44 % carbohydrate; 40 % fat; 16 % protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p < 0.001), representing 22 % total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition.
McKillop
A M
AM
School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland. am.mckillop@ulster.ac.uk
Lindsay
J R
JR
Au
S
S
Mahood
K I
KI
O'Harte
F P M
FP
Flatt
P R
PR
Bell
P M
PM
D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005502:Food; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008297:Male; D013997:Time Factors
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin