title: Pregabalin-associated acute psychosis and epileptiform EEG-changes.
abstract: Pregabalin is a novel anticonvulsive and analgesic drug that has been marketed in Europe for more than a year. The typical side effects are dizziness, somnolence and weight gain. We present a patient who, after unintended rapid up-titration of pregabalin, experienced psychotic symptoms associated with rhythmic EEG-changes resolving completely after discontinuation of pregabalin and benzodiazepine administration.
authors.affiliation: Department of Neurology, University Hospitals Münster, Albert-Schweitzer-Street 33, 48149 Münster, Germany.
authors.forename: Itziar
authors.initials: I
authors.lastname: Olaizola
authors.forename: Tanja
authors.initials: T
authors.lastname: Ellger
authors.forename: Peter
authors.initials: P
authors.lastname: Young
authors.forename: Frank
authors.initials: F
authors.lastname: Bösebeck
authors.forename: Stefan
authors.initials: S
authors.lastname: Evers
authors.forename: Christoph
authors.initials: C
authors.lastname: Kellinghaus
mesh_terms: D000208:Acute Disease; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D009128:Muscle Spasticity / Q000188:drug therapy*; D000069583:Pregabalin; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid