Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids.
Triglycerides are a promising class of material for the parenteral delivery of drugs and have become the focus of tremendous research efforts in recent years. The aim of this study was to investigate the biocompatibility of glyceroltripalmitate as well as the influence of cholesterol and distearoyl-phosphatidyl-choline (DSPC) on the erosion behavior of the lipid. For these investigations, two in vivo studies were carried out, in which cylindrical matrices of 2 mm diameter were manufactured and subcutaneously implanted in immunocompetent NMRI-mice. After excision of the implants, tissue reactions of the animals as well as changes in the weight, shape and microstructure of the implants were investigated. The triglyceride and cholesterol showed good biocompatibility, as indicated by their minimal encapsulation in connective tissue and the absence of inflammatory reactions. Increasing the levels of phospholipid in the implants, however, led to an increased inflammatory reaction. In contrast to cholesterol, which did not affect erosion, the incorporation of DSPC into the triglyceride matrices led to clearly visible signs of degradation.
Guse
C
C
Department of Pharmaceutical Technology, University of Regensburg, Universitätsstrasse 31, D-93040 Regensburg, Germany.
Koennings
S
S
Maschke
A
A
Hacker
M
M
Becker
C
C
Schreiner
S
S
Blunk
T
T
Spruss
T
T
Goepferich
A
A
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism; D001673:Biodegradation, Environmental; D002784:Cholesterol / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism; D004343:Drug Implants; D005260:Female; D005549:Foreign-Body Reaction / Q000139:chemically induced*; D008422:Materials Testing; D051379:Mice; D010713:Phosphatidylcholines / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical; D014280:Triglycerides / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism
D001672:Biocompatible Materials; D004343:Drug Implants; D010713:Phosphatidylcholines; D014280:Triglycerides; D002784:Cholesterol; C005859:tripalmitin; C010942:1,2-distearoyllecithin