No ESCRT to the melanosome: MVB sorting without ubiquitin.
Multivesicular bodies (MVBs) are critical for a variety of cellular functions ranging from lysosomal degradation to the budding of HIV. To date, delivery into MVBs has been dependent on the ESCRT machinery. However, analysis of a melanosomal protein has uncovered an alternative pathway for MVB sorting.
Katzmann
David J
DJ
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 1607 Guggenheim, Rochester, Minnesota 55905, USA.
D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism; D046911:Macromolecular Substances; D020460:Melanosomes / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D021381:Protein Transport; D025801:Ubiquitin / Q000378:metabolism*; D058951:gp100 Melanoma Antigen
D046911:Macromolecular Substances; D008562:Membrane Glycoproteins; D025801:Ubiquitin; D058951:gp100 Melanoma Antigen