Interaction of angiogenic and immune mechanisms in the eye.
Although a critical physiologic process, angiogenesis also contributes to the pathology associated with a variety of ocular diseases. Here we describe immune factors that regulate angiogenesis and review recent attempts to exploit these factors in animal models of ocular disease.
Hendricks
Robert L
RL
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA. hendricksrr@msx.upmc.edu
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism; D005123:Eye / Q000098:blood supply / Q000276:immunology*; D005128:Eye Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D009389:Neovascularization, Pathologic / Q000276:immunology; D018919:Neovascularization, Physiologic / Q000502:physiology*
D016207:Cytokines