[Comparison of coronary angiography findings in diabetic and non-diabetic women with non-ST-segment-elevation acute coronary syndrome].
OBJECTIVE
Compare hemodynamic and angiographic patterns, as well as atherosclerotic lesion morphology, in diabetic and non-diabetic females with unstable angina or non-ST-segment-elevation myocardial infarction (UA/NSTEMI).


METHODS
Two interventional cardiologists determined the presence of severe atherosclerotic lesion, defined as those > or = 70%; plaque morphology, according to the American Heart Association classification; collateral circulation; plus ventricular and aortic pressures. Ejection fraction was calculated by angiography or echocardiography.


RESULTS
During eight and a half years, 645 coronary angiographies were performed in women with UA/NSTEMI. In the present study, 593 female patients were assessed (215 diabetic--36%). This group differed from the non-diabetic in the following aspects: older age (61 +/- 10.6 x 58.1 +/- 11.4), higher prevalence of postmenopausal women and lower prevalence of the smoking habit. Severe three-vessel disease was significantly more frequent in diabetic patients (28% x 10%), as well as totally occluded vessels: 51 (23%) x 54 (14.3%), p < 0.005. Additionally, ejection fraction < 50% was more common in diabetic patients.


CONCLUSIONS
These findings confirm the diffuse pattern of atherosclerotic disease in diabetic patients, as well a greater deterioration of ventricular function, which may be associated to the poorer prognosis seen in this population both in the short- and long-term.
Sousa
José Marconi Almeida de
JM
Universidade Federal de São Paulo, Hospital Santa Marcelina, São Paulo, SP. jmarconi@cardiol.br
Herrman
João L V
JL
Teodoro
Marco
M
Diogo
Sergio
S
Terceiro
Bernardino Bandeira
BB
Paola
Angelo Amato Vincenzo de
AA
Carvalho
Antonio Carlos Camargo
AC
D000789:Angina, Unstable / Q000000981:diagnostic imaging* / Q000209:etiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging*; D005260:Female; D006329:Heart Conduction System / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies