Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains.
The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.
Sabat
Artur
A
National Institute of Public Health, 30/34 Chelmska St., 00-725 Warsaw, Poland.
Melles
Damian C
DC
Martirosian
Gayane
G
Grundmann
Hajo
H
van Belkum
Alex
A
Hryniewicz
Waleria
W
D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics; D002353:Carrier State / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D016106:Methicillin Resistance / Q000235:genetics; D018598:Minisatellite Repeats; D009296:Nasal Cavity / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; D004269:DNA, Bacterial; C118508:SdrC protein, Staphylococcus aureus; C115915:SdrD protein, Staphylococcus aureus; C118507:SdrE protein, Staphylococcus aureus