[The specific features of the cytolytic syndrome in patients with chronic diffuse diseases of the liver in relation to the severity of a pathological process].
The authors consider the molecular mechanisms of cytolysis, the leading pathomorphological syndrome of chronic diffuse hepatic diseases (CDHD), in the context of the relationship of bioradical homeostasis and hydration. A hundred and thirty five males, including 40 patients with CDHD and 95 donors were examined. It has been established that there is a reduction in the activity of alanine aminotransferase and an increase in the de Ritis coefficient over 1.05 and in bioradical homeostatic imbalance due to the less total antioxidative activity below 33% of the normal value, as well as a decrease in the hydration coefficient below 66% of the normal value due to the elevated amount of free water and to the lower amount of bound water. The findings permit one to monitor the course of CDHD and the treatment of patients and to predetermine the use of synthetic antiradical agents to abolish cytolysis.
Podoprigorova
V G
VG
Tsygankova
G M
GM
Farashchuk
N F
NF
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D000975:Antioxidants / Q000627:therapeutic use; D006521:Hepatitis, Chronic / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008103:Liver Cirrhosis / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D013577:Syndrome; D000637:Transaminases / Q000097:blood*; D014867:Water / Q000032:analysis*
D000975:Antioxidants; D014867:Water; D000637:Transaminases; D000410:Alanine Transaminase; C022636:serine-glyoxylate aminotransferase