title: Bone and lean tissue changes following cranial cruciate ligament transection and stifle stabilization.
abstract: Following cranial cruciate ligament transection and extracapsular stabilization, dual-energy X-ray absorptiometry was used to analyze bone mineral content and lean tissue mass in the surgical and nonsurgical legs (n=14) at 0, 2, 4, and 8 weeks, and to evaluate bone mineral content and bone mineral density (BMD) of the proximal, mid-, and distal tibia of both the surgical and nonsurgical legs (n=15) at 0, 5, and 10 weeks. There was significant loss of bone mineral content and lean tissue in the surgical leg compared to the nonsurgical leg. Significant loss in bone mineral content and BMD was detected in the tibia of the surgical leg and was most pronounced in the metaphyseal region.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996-4544, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Francis
authors.forename: Darryl L
authors.initials: DL
authors.lastname: Millis
authors.forename: Laurie L
authors.initials: LL
authors.lastname: Head
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods / Q000662:veterinary; D000704:Analysis of Variance; D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D015519:Bone Density / Q000502:physiology; D004285:Dogs; D005260:Female; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000662:veterinary; D020127:Recovery of Function; D013264:Stifle / Q000601:surgery*; D013977:Tibia / Q000737:chemistry* / Q000000981:diagnostic imaging; D013997:Time Factors