title: Nutraceuticals synergistically promote proliferation of human stem cells.
abstract: A viable alternative to stem cell transplantation is to design approaches that stimulate endogenous stem cells to promote healing and regenerative medicine. Many natural compounds have been shown to promote healing; however, the effects of these compounds on stem cells have not been investigated. We report here the effects of several natural compounds on the proliferation of human bone marrow and human CD34(+) and CD133(+) cells. A dose-related effect of blueberry, green tea, catechin, carnosine, and vitamin D(3) was observed on proliferation with human bone marrow as compared with human granulocyte-macrophage colony-stimulating factor (hGM-CSF). We further show that combinations of nutrients produce a synergistic effect to promote proliferation of human hematopoietic progenitors. This demonstrates that nutrients can act to promote healing via an interaction with stem cell populations.
authors.affiliation: Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA. pbickfor@hsc.usf.edu
authors.forename: Paula C
authors.initials: PC
authors.lastname: Bickford
authors.forename: Jun
authors.initials: J
authors.lastname: Tan
authors.forename: R Douglas
authors.initials: RD
authors.lastname: Shytle
authors.forename: Cyndy D
authors.initials: CD
authors.lastname: Sanberg
authors.forename: Nagwa
authors.initials: N
authors.lastname: El-Badri
authors.forename: Paul R
authors.initials: PR
authors.lastname: Sanberg
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000097:blood; D018952:Antigens, CD34 / Q000097:blood; D001688:Biological Products / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects*; D002336:Carnosine / Q000494:pharmacology; D002392:Catechin / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D002762:Cholecalciferol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006023:Glycoproteins / Q000097:blood; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D010455:Peptides / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; D001688:Biological Products; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides; D010936:Plant Extracts; D002762:Cholecalciferol; D002336:Carnosine; D002392:Catechin