Does laparoscopic removal of nonendometriotic benign ovarian cysts affect ovarian reserve?
BACKGROUND
The objective of this study was to investigate whether laparoscopic excision of nonendometriotic benign ovarian cysts is associated with a significant injury to ovarian reserve.


METHODS
Women selected for IVF-ICSI cycles who previously underwent laparoscopic excision of a monolateral nonendometriotic benign ovarian cyst were retrospectively identified. The operated ovary and the contralateral intact gonad of the same patient were compared in term of basal ovarian volume before initiating ovarian stimulation and number of dominant follicles at the time of human chorionic gonadotropin administration. Non-parametric Wilcoxon Rank test was used to investigate differences between the two ovaries.


RESULTS
Seventeen cases were recruited. The numbers of dominant follicles were 4.6 +/- 2.5 and 2.7 +/- 2.4 in the control ovary and in the previously operated ovary, respectively (p = 0.01). This drop corresponded to a mean reduction of 42% (95% confidence interval: 10-74%). Basal volumes of the intact and the operated gonads were 5.7 +/- 3.3 and 3.4 +/- 2.3 cm3 respectively (p = 0.01), corresponding to a mean reduction of 39% (95% confidence interval: 12-66%).


CONCLUSIONS
Laparoscopic excision of nonendometrioid benign ovarian cysts is associated with a significant injury to ovarian reserve.
Somigliana
Edgardo
E
Infertility Unit, Department of Obstetrics and Gynecology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy. dadosomigliana@yahoo.it
Ragni
Guido
G
Infantino
Mirco
M
Benedetti
Francesca
F
Arnoldi
Mariangela
M
Crosignani
Pier Giorgio
PG
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005307:Fertilization in Vitro; D006801:Humans; D010535:Laparoscopy; D010048:Ovarian Cysts / Q000601:surgery*; D006080:Ovarian Follicle / Q000502:physiology*; D010062:Ovulation Induction; D012189:Retrospective Studies
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female