title: [Impact of hyperbaric oxygenation on nitric balance of gastrointestinal organs at hepatectomy: experimental study].
abstract: The study was undertaken to examine nitrogen metabolism in gastrointenstinal tract tissues in endogenous ammonia intoxication caused by liver resection (LR) and the impact of three-day hyperbaric oxygenation (HBO) on the metabolism. The albino rat samples of arterial (aortic) and venous (portal) blood and the tissues of the stomach, duodenum, and large bowel were the subject of this investigation. HBO was made thrice at 3 ata as a 50-min session within the first three days after LR (15-20% of the mass of the organ). The levels of ammonia, glutamine, and urea were measured. HBO prevents postoperative arterial hyperammonemia, the gastrointestinal accumulation of ammonia, by reducing its accumulation in the portal blood. HBO stimulates the development of LR-caused portal hyperglutaminemia and the decrease of GIT tissue uptake of "arterial" glutamine and regulates the influence of an operation on the levels of this metabolite in GIT tissues. HBO elevates the content of urea in the arterial and portal blood, without affecting the LR-induced change in its GIT tissue concentration. Hyperbaric oxygen regulates adaptive GIT tissue nitrogen metabolic reactions caused in response to liver resection.
authors.forename: P N
authors.initials: PN
authors.lastname: Savilov
mesh_terms: D000641:Ammonia / Q000032:analysis; D000818:Animals; D005260:Female; D041981:Gastrointestinal Tract / Q000737:chemistry / Q000378:metabolism*; D005973:Glutamine / Q000032:analysis; D006498:Hepatectomy; D006931:Hyperbaric Oxygenation; D008099:Liver / Q000601:surgery*; D009584:Nitrogen / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000097:blood / Q000652:urine
chemical_list: D005973:Glutamine; D000641:Ammonia; D014508:Urea; D009584:Nitrogen