title: A synthetic entry to furo[2,3-b]pyridin-4(1H)-ones and related furoquinolinones via iodocyclization.
abstract: [reaction: see text] N-Methyl-4-alkoxy-3-alkynylpyridin-2(1H)-ones readily undergo iodine-promoted 5-endo-heteroannulation under mild conditions to 3-iodofuropyridinium triiodide salts in moderate to good yields. The latter may be dealkylated in situ upon exposure to an iodide anion to provide the corresponding 3-iodofuro[2,3-b]pyridin-4(1H)-ones. The same strategy applies to the formation of furo[2,3-b]quinolin-4(9H)-ones.
authors.affiliation: Laboratoire de Synthèse Organométallique et Molécules Bioactives, CNRS UMR 5181, Université Claude Bernard-Lyon I, ESCPE Lyon. 43, Bd du 11 Novembre 1918, 69622 Villeurbanne, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Aillaud
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bossharth
authors.forename: David
authors.initials: D
authors.lastname: Conreaux
authors.forename: Philippe
authors.initials: P
authors.lastname: Desbordes
authors.forename: Nuno
authors.initials: N
authors.lastname: Monteiro
authors.forename: Geneviève
authors.initials: G
authors.lastname: Balme