Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro.
A standardized extract of red orange juice (ROE) was shown to inhibit proliferation of fibroblast and epithelial prostate cells. These data suggest that the antiproliferative properties of ROE cannot be ascribed to cytotoxic effect and highlight its potential usefulness in the management of benign prostatic hyperplasia.
Vitali
Federica
F
Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, P.le Aldo Moro 5, 00185 Roma, Italy. fvitali@pharma.unime.it
Pennisi
Claudia
C
Tomaino
Antonio
A
Bonina
Francesco
F
De Pasquale
Anna
A
Saija
Antonella
A
Tita
Beatrice
B
D000818:Animals; D001156:Artemia / Q000187:drug effects; D001681:Biological Assay / Q000379:methods; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D032084:Citrus sinensis / Q000737:chemistry* / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D011467:Prostate / Q000166:cytology* / Q000187:drug effects; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D013778:Tetrazolium Salts / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism; D014343:Trypan Blue / Q000378:metabolism
D010936:Plant Extracts; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue; D014343:Trypan Blue