title: Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures.
abstract: Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the patient had significantly fewer seizures on the day of and after administration. These results suggest a useful treatment strategy for patients with refractory epilepsy who have developed resistance to AEDs.
authors.affiliation: Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Friedman
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: French
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam