[Allicor efficacy in lowering the risk of ischemic heart disease in primary prophylaxis].
OBJECTIVE
To assess effects of allicor (a long-acting garlic drug) on the risk of ischemic heart disease (IHD) in primary prophylaxis of cardiovascular diseases.


METHODS
A double blind placebo-controlled study investigated for a year changes in multifactorial risks of cardiovascular events or their complications in 167 patients with hyperlipidemia free of IHD.


RESULTS
In men, intake of allicor for 12 months resulted in a 10.7% reduction of a 10-year absolute risk to develop IHD (p < 0.05) and decreased a 10-year absolute risk of acute myocardial infarction and sudden death by 22.7% (p < 0.05). In women, allicor prevented age-related cardiovascular risk (p < 0.05). Among lipid parameters, the greatest fall was observed for total cholesterol and LDLP cholesterol (p < 0.05) in men by 27.9 and 22.5 mg/dl, in women--by 11.4 and 10.8 mg/dl, respectively.


CONCLUSIONS
Allicor is effective in reducing multifactorial risk of cardiovascular diseases.
Sobenin
I A
IA
Prianishnikov
V V
VV
Kunnova
L M
LM
Rabinovich
E A
EA
Orekhov
A N
AN
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005737:Garlic; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000517:prevention & control*; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D011322:Primary Prevention / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome
D008055:Lipids; D028321:Plant Preparations