title: Small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome: a case report documenting a complete response.
abstract: We describe a case of small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome. Sensorimotor neuropathy had developed 3 years earlier, and neurological symptoms had slowly worsened. Small-cell carcinoma of the esophagus was incidentally diagnosed while investigating the cause of the neurological symptoms. A paraneoplastic neurological syndrome was diagnosed on the basis of cancer and exclusion of other known causes of neurological symptoms. The patient was given combination chemoradiotherapy. There was a complete response to three courses of chemoradiotherapy, with no evidence of disease recurrence 6 years after the diagnosis. There was no progression of paraneoplastic neurological symptoms after the complete response.
authors.affiliation: Department of Internal Medicine, Kitasato University East Hospital, Sagamihara, Kanagawa 228-8555, Japan. ep-doc@kitasato-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Shimoda
authors.forename: Wasaburou
authors.initials: W
authors.lastname: Koizumi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanabe
authors.forename: Katuhiko
authors.initials: K
authors.lastname: Higuchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Sasaki
authors.forename: Norisuke
authors.initials: N
authors.lastname: Nakayama
authors.forename: Mizutomo
authors.initials: M
authors.lastname: Azuma
authors.forename: Katsunori
authors.initials: K
authors.lastname: Saigenji
authors.forename: Tomoya
authors.initials: T
authors.lastname: Katou
authors.forename: Mieko
authors.initials: M
authors.lastname: Ogino
mesh_terms: D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000209:etiology*; D016896:Treatment Outcome