title: Total synthesis of dolabelide D.
abstract: The first total synthesis of dolabelide D (or of any of the closely related dolabelides) has been achieved with a longest linear sequence of 17 steps. Key features of the synthesis include an application of the catalytic asymmetric silane alcoholysis, the tandem silylformylation-crotylsilylation, and a Brook-like 1,4-carbon to oxygen silyl migration.
authors.affiliation: Department of Chemistry, Columbia University, New York, NY 10027, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Park
authors.forename: Steven J
authors.initials: SJ
authors.lastname: O'Malley
authors.forename: Darby R
authors.initials: DR
authors.lastname: Schmidt
authors.forename: James L
authors.initials: JL
authors.lastname: Leighton
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000138:chemical synthesis*; D018942:Macrolides; D008974:Mollusca / Q000737:chemistry; D012821:Silanes / Q000737:chemistry
chemical_list: D004224:Diterpenes; D018942:Macrolides; D012821:Silanes; C509949:dolabelide D