title: Mosquito larvicidal activity of active constituent derived from Chamaecyparis obtusa leaves against 3 mosquito species.
abstract: Mosqutio larvicidal activity of Chamaecyparis obtusa leaf-derived materials against the 4th-stage larvae of Aedes aegypti (L.), Ochlerotatus togoi (Theobald), and Culex pipiens pallens (Coquillett) was examined in the laboratory. A crude methanol extract of C. obtusa leaves was found to be active (percent mortality rough) against the 3 species larvae; the hexane fraction of the methanol extract showed a strong larvicidal activity (100% mortality) at 100 ppm. The bioactive component in the C. obtusa leaf extract was characterized as beta-thujaplicin by spectroscopic analyses. The LC50 value of beta-thujaplicin was 2.91, 2.60, and 1.33 ppm against Ae. aegypti, Oc. togoi, and Cx. pipiens pallens larvae. This naturally occurring C. obtusa leaves-derived compound merits further study as a potential mosquito larval control agent or lead compound.
authors.affiliation: Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture and Life Science, Chonbuk National University, Chonju, South Korea.
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Jang
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Jeon
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000330:Aedes; D000818:Animals; D029780:Chamaecyparis; D003465:Culex; D007814:Larva; D039821:Monoterpenes; D009032:Mosquito Control / Q000379:methods*; D044969:Ochlerotatus; D009946:Organothiophosphorus Compounds; D010936:Plant Extracts; D018515:Plant Leaves; D014334:Tropolone / Q000031:analogs & derivatives
chemical_list: D039821:Monoterpenes; D009946:Organothiophosphorus Compounds; D010936:Plant Extracts; C014153:pirimiphos methyl; D014334:Tropolone; C009479:beta-thujaplicin