[Transient central diabetes insipidus during a valproic acid poisoning].
A 39-year-old man was hospitalized after divalproate self-poisoning. He presented coma requiring tracheal intubation and mechanical ventilation at 11 hours and central diabetes insipidus. Serum valproic acid concentration was 590 mg/l at 30 hours. Progressive improvement occurred after hydratation and administration of vasopressin.
Lemaire
X
X
Service de Réanimation Médicale Assistance Respiratoire, Hôpital Gui-de-Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 05, France.
Corne
P
P
Jonquet
O
O
D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy; D003128:Coma / Q000139:chemically induced; D003919:Diabetes Insipidus / Q000139:chemically induced* / Q000188:drug therapy / Q000628:therapy; D005440:Fluid Therapy; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D011041:Poisoning / Q000097:blood / Q000628:therapy; D011141:Polyuria / Q000209:etiology; D012121:Respiration, Artificial; D013406:Suicide, Attempted; D014635:Valproic Acid / Q000506:poisoning*; D014667:Vasopressins / Q000627:therapeutic use
D014667:Vasopressins; D014635:Valproic Acid