title: Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis.
abstract: The acinar epithelial cells of the lacrimal gland are responsible for the production, packaging and regulated exocytosis of tear proteins into ocular surface fluid. This review summarizes new findings on the mechanisms of exocytosis in these cells. Participating proteins are discussed within the context of different categories of trafficking effectors including targeting and specificity factors (rabs, SNAREs) and transport factors (microtubules, actin filaments and motor proteins). Recent information describing fundamental changes in basic exocytotic mechanisms in the NOD mouse, an animal model of Sjögren's syndrome, is presented.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, 1985 Zonal Avenue, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Kaijin
authors.initials: K
authors.lastname: Wu
authors.forename: Galina V
authors.initials: GV
authors.lastname: Jerdeva
authors.forename: Silvia R
authors.initials: SR
authors.lastname: da Costa
authors.forename: Eunbyul
authors.initials: E
authors.lastname: Sou
authors.forename: Joel E
authors.initials: JE
authors.lastname: Schechter
authors.forename: Sarah F
authors.initials: SF
authors.lastname: Hamm-Alvarez
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D004195:Disease Models, Animal; D005089:Exocytosis / Q000502:physiology*; D005136:Eye Proteins / Q000378:metabolism; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D007765:Lacrimal Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D016688:Mice, Inbred NOD; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009218:Myosins / Q000378:metabolism; D011817:Rabbits; D050600:SNARE Proteins / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism*; D012859:Sjogren's Syndrome / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000199:Actins; D005136:Eye Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D009218:Myosins; D020691:rab GTP-Binding Proteins