Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM.
[reaction: see text] A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide.
Lu
Kui
K
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing, China.
Huang
Mengwei
M
Xiang
Zheng
Z
Liu
Yongxiang
Y
Chen
Jiahua
J
Yang
Zhen
Z
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D001688:Biological Products; D018942:Macrolides; C465999:hygrolidin; C036978:concanamycin A; C040929:bafilomycin A1