Hydrogen abstraction from neurotransmitters by active oxygen species facilitated by intramolecular hydrogen bonding in the radical intermediates.
The reactivity of neurotransmitters toward hydrogen abstraction by an active oxygen species (the cumylperoxyl radical) is comparable to that of a strong antioxidant such as catechin due to the strong intramolecular hydrogen bonding, which has been successfully detected by ESR.
Ohkubo
Kei
K
Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, JST, Suita, Osaka 565-0871, Japan.
Moro-oka
Yoshihiko
Y
Fukuzumi
Shunichi
S
D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006859:Hydrogen; D006860:Hydrogen Bonding; D007700:Kinetics; D008958:Models, Molecular; D018377:Neurotransmitter Agents / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry*
D005609:Free Radicals; D018377:Neurotransmitter Agents; D017382:Reactive Oxygen Species; D006859:Hydrogen