In vitro antitumour and antibacterial studies of some Pt(IV) dithiocarbamate complexes.
A few Pt(IV) complexes of the type [Pt(L)(2)Cl(2)] [where L=morpholine dithiocarbamate (L(1)), aniline dithiocarbamate (L(2)), N-(methyl, cyclohexyl) dithiocarbamate (L(3)) and N-(ethyl, cyclohexyl) dithiocarbamate (L(4))] were synthesized. The complexes have been characterized by elemental analysis, molar conductance, IR, electronic, (1)H and (13)C NMR spectroscopic studies. The ligands found to act in monobasic bidentate fashion. Cyclicvoltammetric studies, antibacterial and in vitro antitumour studies were also carried out.
Manav
N
N
Department of Chemistry, University of Delhi, Delhi 110007, India. navneet92@rediffmail.com
Mishra
A K
AK
Kaushik
N K
NK
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D017671:Platinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D013055:Spectrophotometry, Infrared; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D017671:Platinum Compounds; D013859:Thiocarbamates