Beyond Mfold: recent advances in RNA bioinformatics.
Computational analysis of RNA secondary structure is a classical field of biosequence analysis, which has recently gained momentum due to the manyfold regulatory functions of RNA that have become apparent. We present five recent computational approaches that address the problems of synoptic folding space analysis, pseudoknot prediction, structure alignment, comparative structure prediction, and miRNA target prediction. All these programs are in current use and are available via the Bielefeld Bioinformatics Server at .
Reeder
Jens
J
Faculty of Technology, Bielefeld University, Germany.
Höchsmann
Matthias
M
Rehmsmeier
Marc
M
Voss
Björn
B
Giegerich
Robert
R
D000818:Animals; D001483:Base Sequence; D019295:Computational Biology / Q000639:trends*; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid; D012984:Software
D012313:RNA