title: Meta-analysis of observational studies of ileorectal versus ileal pouch-anal anastomosis for familial adenomatous polyposis.
abstract: BACKGROUND
  Surgery for familial adenomatous polyposis (FAP) aims to minimize cancer risk while providing good functional outcome. Colectomy with ileorectal anastomosis and proctocolectomy with ileal pouch-anal anastomosis both offer this, but there is no clear consensus about which is better.
  
  
  METHODS
  This is a meta-analysis of comparative studies published between 1991 and 2003 reporting early and late postoperative adverse events, functional outcomes and quality of life.
  
  
  RESULTS
  Twelve studies containing 1002 patients (53.4 per cent ileal pouch, 46.6 per cent ileorectal anastomosis) were identified. Bowel frequency (weighted mean difference 1.62 (95 per cent confidence interval (c.i.) 1.05 to 2.20)), night defaecation (odds ratio (OR) 6.64 (95 per cent c.i. 2.99 to 14.74)) and use of incontinence pads (OR 2.72 (95 per cent c.i. 1.02 to 7.23)) were significantly less in the ileorectal group, although faecal urgency was reduced with the ileal pouch (odds ratio 0.43 (95 per cent c.i. 0.23 to 0.80)). Reoperation within 30 days was more common after ileal pouch construction (23.4 versus 11.6 per cent; OR 2.11 (95 per cent c.i. 1.21 to 3.70)). There was no significant difference between the techniques in terms of sexual dysfunction, dietary restriction, or postoperative complications. Rectal cancer was a diagnosis only in the ileorectal group (5.5 per cent).
  
  
  CONCLUSIONS
  Ileal pouch and ileorectal anastomoses have individual merits. Further research is needed to determine which most benefits patients with FAP.
authors.affiliation: Department of Surgical Oncology and Technology, Imperial College London, St Mary's Hospital, London, UK.
authors.forename: O
authors.initials: O
authors.lastname: Aziz
authors.forename: T
authors.initials: T
authors.lastname: Athanasiou
authors.forename: V W
authors.initials: VW
authors.lastname: Fazio
authors.forename: R J
authors.initials: RJ
authors.lastname: Nicholls
authors.forename: A W
authors.initials: AW
authors.lastname: Darzi
authors.forename: J
authors.initials: J
authors.lastname: Church
authors.forename: R K S
authors.initials: RK
authors.lastname: Phillips
authors.forename: P P
authors.initials: PP
authors.lastname: Tekkis
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery*; D000714:Anastomosis, Surgical; D039021:Colonic Pouches; D005500:Follow-Up Studies; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology; D016737:Proctocolectomy, Restorative / Q000379:methods*; D017594:Publication Bias; D011788:Quality of Life; D012086:Reoperation / Q000706:statistics & numerical data; D016896:Treatment Outcome