title: Role of HIV-1 minority populations on resistance mutational pattern evolution and susceptibility to protease inhibitors.
abstract: We investigated, in the protease and GAG cleavage sites, the role of minority populations on the evolution of resistance to a subsequent boosted protease inhibitor (PI) regimen after a first failure to nelfinavir. Two pathways were observed: the addition of mutations to a currently dominant genotype when minority variants are not shown, or the emergence of a minority variant as a dominant strain. These minor species, not detected by standard genotype, may influence PI susceptibility.
authors.affiliation: Department of Virology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Roquebert
authors.forename: Isabelle
authors.initials: I
authors.lastname: Malet
authors.forename: Marc
authors.initials: M
authors.lastname: Wirden
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Valantin
authors.forename: Anne
authors.initials: A
authors.lastname: Simon
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
mesh_terms: D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D019143:Evolution, Molecular; D015683:Gene Products, gag / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D016333:HIV Protease / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D019888:Nelfinavir / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D015683:Gene Products, gag; D017320:HIV Protease Inhibitors; D016333:HIV Protease; D019888:Nelfinavir