Tracing the origin of Brazilian HTLV-1 as determined by analysis of host and viral genes.
We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu-Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence rate in KZN was 1.7%. All sequences belonged to the A subgroup. The presence of South African sequences in two different clusters from Brazil, and the finding of the beta-globin haplotype in infected hosts are consistent with the transmission of this virus from southern Africa to Brazil.
Alcantara
Luiz C J
LC
Public Health Advanced Laboratory, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
de Oliveira
Tulio
T
Gordon
Michelle
M
Pybus
Oliver
O
Mascarenhas
Rita Elizabeth
RE
Seixas
Magda O
MO
Gonçalves
Marilda
M
Hlela
Carol
C
Cassol
Sharon
S
Galvão-Castro
Bernardo
B
D001938:Brazil / Q000453:epidemiology; D019143:Evolution, Molecular; D005814:Genes, Viral; D014644:Genetic Variation; D005914:Globins / Q000235:genetics; D015490:HTLV-I Infections / Q000453:epidemiology / Q000235:genetics*; D006239:Haplotypes; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods; D010802:Phylogeny; D016036:Seroepidemiologic Studies; D013019:South Africa; D020079:Terminal Repeat Sequences
D005914:Globins