Pd(II)-catalyzed conversion of styrene derivatives to acetals: impact of (-)-sparteine on regioselectivity.
[reaction: see text] Pd[(-)-sparteine]Cl(2) catalyzes the formation of dialkyl acetals from styrene derivatives with Markovnikov regioselectivity. The substrate scope of this reaction has been investigated, and initial mechanistic studies indicate that the reaction proceeds through an enol ether intermediate and a Pd-hydride.
Balija
Amy M
AM
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850, USA.
Stowers
Kara J
KJ
Schultz
Mitchell J
MJ
Sigman
Matthew S
MS
D002384:Catalysis; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013034:Sparteine / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry*
D013343:Styrenes; D013034:Sparteine; D010165:Palladium