title: Beneficial effects of Zingiber officinale on goldthioglucose induced obesity.
abstract: Goldthioglucose induces in mice a significant increase in body weight, glucose, insulin and lipid levels. Treatment with 250 mg/kg of methanol and ethyl acetate extracts of Zingiber officinale for 8 weeks produces significant reduction in body weight, glucose, insulin and lipid levels as compared to obese control mice. The reduction in elevated glucose along with elevated insulin levels indicates that the treatment with Z. officinale improves insulin sensitivity.
authors.affiliation: Department of Pharmacology, L.M.College of Pharmacy, Navarangpura, Ahmedabad-380009, India. goyalrk@hotmail.com
authors.forename: Ramesh K
authors.initials: RK
authors.lastname: Goyal
authors.forename: Sanjay V
authors.initials: SV
authors.lastname: Kadnur
mesh_terms: D000085:Acetates / Q000737:chemistry; D000818:Animals; D006051:Aurothioglucose / Q000008:administration & dosage / Q000633:toxicity; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D020939:Zingiber officinale / Q000737:chemistry*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D000432:Methanol / Q000737:chemistry; D051379:Mice; D009765:Obesity / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000085:Acetates; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D006051:Aurothioglucose; C007650:ethyl acetate; D000432:Methanol