Pregabalin-associated acute psychosis and epileptiform EEG-changes.
Pregabalin is a novel anticonvulsive and analgesic drug that has been marketed in Europe for more than a year. The typical side effects are dizziness, somnolence and weight gain. We present a patient who, after unintended rapid up-titration of pregabalin, experienced psychotic symptoms associated with rhythmic EEG-changes resolving completely after discontinuation of pregabalin and benzodiazepine administration.
Olaizola
Itziar
I
Department of Neurology, University Hospitals Münster, Albert-Schweitzer-Street 33, 48149 Münster, Germany.
Ellger
Tanja
T
Young
Peter
P
Bösebeck
Frank
F
Evers
Stefan
S
Kellinghaus
Christoph
C
D000208:Acute Disease; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D009128:Muscle Spasticity / Q000188:drug therapy*; D000069583:Pregabalin; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid