title: Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM.
abstract: [reaction: see text] A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide.
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Lu
authors.forename: Mengwei
authors.initials: M
authors.lastname: Huang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiang
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jiahua
authors.initials: J
authors.lastname: Chen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001688:Biological Products; D018942:Macrolides; C465999:hygrolidin; C036978:concanamycin A; C040929:bafilomycin A1