title: Nepalensinols D-G, new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase II.
abstract: Four new resveratrol oligomers, nepalensinols D-G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5-15 microM.
authors.affiliation: Meiji Dairies Corporation, Shinsuna, Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamada
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayashi
authors.forename: Ryota
authors.initials: R
authors.lastname: Tsuji
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kakumoto
authors.forename: Shogo
authors.initials: S
authors.lastname: Ikeda
authors.forename: Takuji
authors.initials: T
authors.lastname: Hoshino
authors.forename: Ken
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Kimiko
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ito
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nozaki
mesh_terms: D029785:Cyperaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D000077185:Resveratrol; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D010636:Phenols; D013267:Stilbenes; D059005:Topoisomerase II Inhibitors; D000077185:Resveratrol