Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder.
Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5' region, the coding region (exons 2-4), and the 3' noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD.
Nakamura
Kazuhiko
K
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan. nakamura@hama-med.ac.jp
Yamada
Kazuo
K
Iwayama
Yoshimi
Y
Toyota
Tomoko
T
Furukawa
Aizou
A
Takimoto
Takahiro
T
Terayama
Hayato
H
Iwahashi
Kazuhiko
K
Takei
Nori
N
Minabe
Yoshio
Y
Sekine
Yoshimoto
Y
Suzuki
Katsuaki
K
Iwata
Yasuhide
Y
Pillai
Anitha
A
Nakamoto
Yurie
Y
Ikeda
Kazutaka
K
Yoshii
Mitsunobu
M
Fukunishi
Isao
I
Yoshikawa
Takeo
T
Mori
Norio
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020125:Mutation, Missense; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011963:Receptors, GABA-A / Q000235:genetics*
D011963:Receptors, GABA-A