title: Clinically isolated syndromes: a new oligoclonal band test accurately predicts conversion to MS.
abstract: BACKGROUND
  Patients with a clinically isolated demyelinating syndrome (CIS) are at risk of developing a second attack, thus converting into clinically definite multiple sclerosis (CDMS). Therefore, an accurate prognostic marker for that conversion might allow early treatment. Brain MRI and oligoclonal IgG band (OCGB) detection are the most frequent paraclinical tests used in MS diagnosis. A new OCGB test has shown high sensitivity and specificity in differential diagnosis of MS.
  
  
  OBJECTIVE
  To evaluate the accuracy of the new OCGB method and of current MRI criteria (MRI-C) to predict conversion of CIS to CDMS.
  
  
  METHODS
  Fifty-two patients with CIS were studied with OCGB detection and brain MRI, and followed up for 6 years. The sensitivity and specificity of both methods to predict conversion to CDMS were analyzed.
  
  
  RESULTS
  OCGB detection showed a sensitivity of 91.4% and specificity of 94.1%. MRI-C had a sensitivity of 74.23% and specificity of 88.2%. The presence of either OCGB or MRI-C studied simultaneously showed a sensitivity of 97.1% and specificity of 88.2%.
  
  
  CONCLUSIONS
  The presence of oligoclonal IgG bands is highly specific and sensitive for early prediction of conversion to multiple sclerosis. MRI criteria have a high specificity but less sensitivity. The simultaneous use of both tests shows high sensitivity and specificity in predicting clinically isolated demyelinating syndrome conversion to clinically definite multiple sclerosis.
authors.affiliation: Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain. jmasjuan.hrc@salud.madrid.org
authors.forename: J
authors.initials: J
authors.lastname: Masjuan
authors.forename: J C
authors.initials: JC
authors.lastname: Alvarez-Cermeño
authors.forename: N
authors.initials: N
authors.lastname: García-Barragán
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Sánchez
authors.forename: M
authors.initials: M
authors.lastname: Espiño
authors.forename: M C
authors.initials: MC
authors.lastname: Sádaba
authors.forename: P
authors.initials: P
authors.lastname: González-Porqué
authors.forename: J
authors.initials: J
authors.lastname: Martínez San Millán
authors.forename: L M
authors.initials: LM
authors.lastname: Villar
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D015203:Reproducibility of Results
chemical_list: D007074:Immunoglobulin G