Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion.
The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth. In addition, we found that PL increased macrophage NO production. These results suggest that PL has two antimetastatic functions, i.e., it acts as an immunopotentiator and as a direct inhibitor of cancer cell adhesion.
Han
Sang-Bae
SB
Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yusong, Taejon.
Lee
Chang Woo
CW
Kang
Jong Soon
JS
Yoon
Yeo Dae
YD
Lee
Ki Hoon
KH
Lee
Kiho
K
Park
Song-Kyu
SK
Kim
Hwan Mook
HM
D000276:Adjuvants, Immunologic; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D001487:Basidiomycota / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000235:genetics; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control; D009368:Neoplasm Transplantation; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D011134:Polysaccharides / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000972:Antineoplastic Agents, Phytogenic; D007075:Immunoglobulin M; D009573:Nitrites; D011134:Polysaccharides; D009569:Nitric Oxide