Man as living bioreactor: fate of an exogenously prepared customized tissue-engineered mandible.
In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.
Warnke
Patrick H
PH
Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold-Heller-Str. 16, 24105 Kiel, Germany. warnke@mkg.uni-kiel.de
Wiltfang
Jörg
J
Springer
Ingo
I
Acil
Yahya
Y
Bolte
Hendrik
H
Kosmahl
Markus
M
Russo
Paul A J
PA
Sherry
Eugene
E
Lützen
Ulf
U
Wolfart
Stefan
S
Terheyden
Hendrik
H
D001706:Biopsy; D019149:Bioreactors; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D001861:Bone Regeneration; D018786:Bone Substitutes; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008334:Mandible / Q000033:anatomy & histology* / Q000378:metabolism / Q000473:pathology; D008339:Mandibular Neoplasms / Q000378:metabolism / Q000628:therapy*; D008875:Middle Aged; D011877:Radionuclide Imaging; D019651:Plastic Surgery Procedures / Q000379:methods*; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D014025:Titanium / Q000737:chemistry; D014057:Tomography, X-Ray Computed
D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D014025:Titanium