Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.
A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor.
Kumar
Atul
A
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. dratulsax@gmail.com
Pathak
S R
SR
Ahmad
Pervez
P
Ray
S
S
Tewari
P
P
Srivastava
A K
AK
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009281:Naphthalenes; C031721:naphthalene; D013311:Streptozocin