title: Drug resistance among smear-positive tuberculosis patients in Ho Chi Minh City, Vietnam.
abstract: OBJECTIVE
  To assess the pattern of drug resistance among smear-positive tuberculosis (TB) patients in an inner city area in Vietnam.
  
  
  METHODS
  A random sample of patients diagnosed by the national TB programme (NTP) were offered HIV testing and submitted sputum for Mycobacterium tuberculosis drug sensitivity testing.
  
  
  RESULTS
  Of 1433 isolates from new patients, 360 (25%) were resistant to isoniazid (INH), 57 (4.0%) to rifampicin (RMP), 421 (29%) to streptomycin (SM) and 28 (2.0%) to ethambutol. Among 401 previously treated patients, this was 218 (54%), 109 (27%), 217 (54%) and 26 (7%), respectively. Multidrug resistance (MDR) was observed in 55 (3.8%) new and 102 (25%) previously treated patients. RMP resistance was strongly associated with resistance to INH (OR 46) and INH plus SM (OR 91, P = 0.004). Prevalence of drug resistance tended to decrease with age. Neither any resistance nor MDR was significantly associated with HIV infection.
  
  
  CONCLUSIONS
  In this inner city area, levels of drug resistance, in particular of MDR among previously treated patients, are high. This may be related to the use of NTP regimens in the context of highly prevalent combined SM and INH resistance which may favour acquisition of RMP resistance.
authors.affiliation: Pham Ngoc Thach TB and Lung Disease Hospital, Ho Chi Minh City, Vietnam.
authors.forename: H T
authors.initials: HT
authors.lastname: Quy
authors.forename: T N
authors.initials: TN
authors.lastname: Buu
authors.forename: F G J
authors.initials: FG
authors.lastname: Cobelens
authors.forename: N T N
authors.initials: NT
authors.lastname: Lan
authors.forename: C S B
authors.initials: CS
authors.lastname: Lambregts
authors.forename: M W
authors.initials: MW
authors.lastname: Borgdorff
mesh_terms: D000293:Adolescent; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D015995:Prevalence; D012189:Retrospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D014505:Urban Population; D014744:Vietnam / Q000453:epidemiology
chemical_list: D000904:Antibiotics, Antitubercular