[Head and neck manifestations and management of Wegener's granulomatosis].
OBJECTIVE
To explore the characteristic and management of Wegener's granulomatosis in head and neck.


METHODS
Forty-two cases with Wegener's granulomatosis were retrospectively analyzed clinical characteristics, head and neck manifestations, biopsy, ANCA test, and management were respectively recorded. Cyclophosphamide and Prednisone are the mainstay of medical therapy.


RESULTS
All cases presented with multiple organ systems involvement. Nasal involvement occurred most in head and neck, the occurred rate was 81.0%, the rate of first-occurred signs and symptoms was 47.6%. The diagnosis rate by biopsy was 67.6%. The total positive rate of ANCA test was 97.4%.


CONCLUSIONS
Head and neck involvement in Wegener's granulomatosis is most common and complicated. ANCA test and biopsy are the most main means in the diagnosis of Wegener's granulomatosis. Medical therapy is the mainstay of treatment in Wegener's granulomatosis, whereas surgery is reserved for selected head and neck manifestations.
Li
Qingming
Q
Department of Otorhinolaryngology, Peking Union Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. qingmingly@yahoo.com.cn
Zhang
Baoquan
B
Peng
Peihong
P
Gao
Zhiqiang
Z
Yin
Haijin
H
Feng
Guodong
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006257:Head / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000473:pathology*; D009666:Nose / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult