Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury.
Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.
Kimura
Kiminori
K
First Department of Internal Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu-shi Gifu 501-1194, Japan. kkimura@cc.gifu-u.ac.jp
Nagaki
Masahito
M
Nishihira
Jun
J
Satake
Shinichi
S
Kuwata
Kazuo
K
Moriwaki
Hisataka
H
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D002461:Cell Line, Transformed; D002999:Clone Cells; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D008099:Liver / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism / Q000821:virology
D000906:Antibodies; D008263:Macrophage Migration-Inhibitory Factors