title: Room temperature Au(I)-catalyzed exo-selective cycloisomerization of acetylenic acids: an entry to functionalized gamma-lactones.
abstract: A highly efficient gold-catalyzed cyclization reaction of various functionalized acetylenic acids is described. The cyclizations are conducted in the presence of Au(I) catalyst in acetonitrile at room temperature in a short reaction time. The reaction conditions are compatible with several functional groups, such as ester, alkene, alkyne, chloro, and free or protected alcohol, and lead to original gamma-lactones in good to excellent yields.
authors.affiliation: Laboratoire de Synthèse Sélective Organique et Produits Naturels, E.N.S.C.P., UMR 7573, 11 rue P. et M. Curie, F-75231 Paris Cedex 05, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Genin
authors.forename: Patrick Yves
authors.initials: PY
authors.lastname: Toullec
authors.forename: Sylvain
authors.initials: S
authors.lastname: Antoniotti
authors.forename: Célia
authors.initials: C
authors.lastname: Brancour
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Genêt
authors.forename: Véronique
authors.initials: V
authors.lastname: Michelet