title: Multidrug resistance among different serotypes of clinical Salmonella isolates in Taiwan.
abstract: Of the 798 clinical Salmonella isolates collected from multiple hospitals in Taiwan, resistance to ampicillin (48.5%), chloramphenicol (55.3%), streptomycin (59.0%), sulfamethoxazole (68.0%), and tetracycline (67.8%) was high, whereas resistance to all 5 antimicrobials (ACSSuT R-type) comprised 327 (41%) and was highly prevalent in Salmonella enterica serotype Typhimurium (72.7%, 176/242), the most common serotype. Additional resistance to trimethoprim was present in 155 (19.4% overall) of the ACSSuT R-type isolates from several serotypes. Reduced susceptibility to fluoroquinolone (FQ) (ciprofloxacin MIC >0.125-1 microg/mL and nalidixic acid-resistant) was detected in 223 (27.9%) isolates including 117 (14.7% overall) that were also ACSSuT-resistant. Full resistance to FQ was detected in Salmonella Choleraesuis (35.5%, 6/17) and Salmonella Schwarzengrund (16.7%, 10/60); both serotypes were also multiresistant to other antimicrobials. Studies are needed to determine the sources of different multidrug-resistant serotypes. Continued national surveillance is underway to monitor changes in resistance trends and to detect further emergence of resistant Salmonella serotypes in Taiwan.
authors.affiliation: Division of Clinical Research, National Health Research Institutes, Zhunan 350, Taiwan. lauderdale@nhri.org.tw
authors.forename: Tsai-Ling
authors.initials: TL
authors.lastname: Lauderdale
authors.forename: Frank M
authors.initials: FM
authors.lastname: Aarestrup
authors.forename: Pei-Chen
authors.initials: PC
authors.lastname: Chen
authors.forename: Jui-Fen
authors.initials: JF
authors.lastname: Lai
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Shiau
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Huang
authors.forename: Che-Lun
authors.initials: CL
authors.lastname: Hung
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D012475:Salmonella / Q000145:classification* / Q000187:drug effects*; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology; D012703:Serotyping; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents