Pituitary thyroid resistance syndrome.
Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by goiter and biochemically by elevated circulating free thyroid hormone levels in the presence of measurable serum thyroid-stimulating hormone (TSH) concentrations. About 85% of patients with RTH harbor mutations in thyroid hormone receptor [beta] (TR[beta]). Even rarer is pituitary thyroid resistance syndrome. We report a case of a 35-year-old man who presented with hypermetabolic symptoms with elevated levels of thyroid hormones, associated with nonsuppressed thyrotropin (TSH). When treated with anti-thyroid drugs, his thyroid hormone levels normalized and TSH increased, suggesting thyroid resistance at the pituitary level.
Norlela
S
S
Endocrine Unit, Department of Medicine, Faculty of Medicine Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur.
Nor Azmi
K
K
Khalid
B A K
BA
D000328:Adult; D006801:Humans; D008297:Male; D010900:Pituitary Diseases / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D018382:Thyroid Hormone Resistance Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy