title: Carotid atherosclerosis is not related to past tuberculosis in hypercholesterolemic patients.
abstract: BACKGROUND
  Tuberculosis is a chronic recurrent infection and inflammation is part of the disease which may remain undiagnosed for months. Furthermore immunization with recombinant heat shock protein-65-rich mycobacterium tuberculosis increased atherogenesis in hypercholesterolemic animal models.
  
  
  OBJECTIVE
  To investigate the potential interrelationships between past tuberculosis with carotid and femoral atherosclerosis in hypercholesterolemic patients.
  
  
  METHODS
  Case control study in a university hospital.
  
  
  METHODS
  Two groups of hypercholesterolemic patient group (n=147) studied in a cardiovascular prevention unit during the same quarter, age (+/-1 year) and sex-matched. The first group presented a history of tuberculosis in the past and the second group never.
  
  
  METHODS
  Atherosclerosis was assessed by carotid and femoral external echography. Measurements of maximum plaque diameter were done in longitudinal planes, and the extent of atherosclerosis was graded according to the most severe visible changes on the scanned arteries.
  
  
  RESULTS
  The frequency and the distribution of atherosclerosis was similar in the two groups, whatever the arterial site explored, carotid or femoral. None of the clinical and biological studied variables were different between the two groups of patients.
  
  
  CONCLUSIONS
  Past tuberculosis is not associated with increased frequency of atherosclerotic lesions in hypercholesterolemic patients.
authors.affiliation: Unités de Prévention Cardiovasculaire, Service d'Endocrinologie-Métabolisme, Groupe Hospitalier Pitié-Salpétrière, France. philippe.giral@psl.ap-hop-paris.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Giral
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Kahn
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: André
authors.forename: Valérie
authors.initials: V
authors.lastname: Carreau
authors.forename: Caroline
authors.initials: C
authors.lastname: Dourmap
authors.forename: Eric
authors.initials: E
authors.lastname: Bruckert
authors.forename: M John
authors.initials: MJ
authors.lastname: Chapman
mesh_terms: D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000382:microbiology*; D016022:Case-Control Studies; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology*; D014463:Ultrasonography