title: Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro.
abstract: A standardized extract of red orange juice (ROE) was shown to inhibit proliferation of fibroblast and epithelial prostate cells. These data suggest that the antiproliferative properties of ROE cannot be ascribed to cytotoxic effect and highlight its potential usefulness in the management of benign prostatic hyperplasia.
authors.affiliation: Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, P.le Aldo Moro 5, 00185 Roma, Italy. fvitali@pharma.unime.it
authors.forename: Federica
authors.initials: F
authors.lastname: Vitali
authors.forename: Claudia
authors.initials: C
authors.lastname: Pennisi
authors.forename: Antonio
authors.initials: A
authors.lastname: Tomaino
authors.forename: Francesco
authors.initials: F
authors.lastname: Bonina
authors.forename: Anna
authors.initials: A
authors.lastname: De Pasquale
authors.forename: Antonella
authors.initials: A
authors.lastname: Saija
authors.forename: Beatrice
authors.initials: B
authors.lastname: Tita
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D001681:Biological Assay / Q000379:methods; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D032084:Citrus sinensis / Q000737:chemistry* / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D011467:Prostate / Q000166:cytology* / Q000187:drug effects; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D013778:Tetrazolium Salts / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism; D014343:Trypan Blue / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue; D014343:Trypan Blue