title: Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing.
abstract: We report the case of a 19-year-old pregnant woman who presented with a nipple tumor. The lesion consisted in a spindle-cell proliferation with histologic features similar to those of fibrous histiocytoma, with a highly vascularized stroma. Although it showed low mitotic activity, scattered marked atypical cells with prominent nucleoli were identified, thus raising concern about the benign nature of the tumor. Immunohistochemical evaluation revealed that the spindle cells were diffusely positive for vimentin, focally positive for CD68, and negative for all the other tested antibodies. The patient had a total excision of the lesion and she is free of disease after 30 months. To our knowledge this is the first reported case of a lesion of this type in the nipple after body-piercing.
authors.affiliation: Department of Gynecology & Obstetrics, Hospital Clínic, University of Barcelona, Andorra, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Castillo
authors.forename: A
authors.initials: A
authors.lastname: Sanjuán
authors.forename: N
authors.initials: N
authors.lastname: Pérez
authors.forename: G
authors.initials: G
authors.lastname: Zanón
authors.forename: N
authors.initials: N
authors.lastname: Bons
authors.forename: M
authors.initials: M
authors.lastname: Vilanova
authors.forename: J A
authors.initials: JA
authors.lastname: Vanrell
authors.forename: M J
authors.initials: MJ
authors.lastname: Merino
authors.forename: P L
authors.initials: PL
authors.lastname: Fernández
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D046288:Body Piercing / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D049109:Cell Proliferation; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009558:Nipples / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule